WorldWideScience

Sample records for stronger beam-beam impact

  1. Impact of beam-beam effects on precision luminosity measurements at the ILC

    CERN Document Server

    Rimbault, C; Mönig, K; Schulte, D

    2007-01-01

    In this paper, the impact of beam-beam effects on the precision luminosity measurement at the International Linear Collider is investigated quantitatively for the first time. GUINEA-PIG, a beam-beam interaction simulation tool, is adapted to treat the space charge effects affecting the Bhabha events used in this measurement. The biases due to the resulting changes in kinematics are evaluated for different center-of-mass energies and beam parameters.

  2. LHC MD2877: Beam-beam long range impact on coupling measurements

    CERN Document Server

    Wenninger, Jorg; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fuchsberger, Kajetan; Hostettler, Michi; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; Valuch, Daniel; Garcia-Tabares Valdivieso, Ana; CERN. Geneva. ATS Department

    2018-01-01

    The LHC is now operating with a tune separation of ∼0.004 in collision. This puts tight constraints on the allowed transverse coupling since a |C−| larger than a fraction of the fractional tune split may lead to beam instabilities. In the last years a new tool based on the ADT used in a similar way as an AC-dipole to excite the beam was developed. The ADT AC-dipole gives coherent oscillations without increasing the beam emittance. These oscillations are analyzed automatically to obtain the value of the coupling. A coupling measurement campaign was done in 2017 and while the correction converged and stayed rather constant over time it was observed that depending on the target bunch and filling scheme the results could vary by Δ|C−| ∼ 0.002. In this MD report we investigated 3 different bunches, one with Long Range Beam-Beam (LRBB) in IPs 1 and 5, one with LRBB in all IPs and one with no LRBB. The results indicate that there are differences in coupling between the bunches experiencing different LR...

  3. Coherent beam-beam effects

    International Nuclear Information System (INIS)

    Chao, A.W.

    1992-01-01

    There are two physical pictures that describe the beam-beam interaction in a storage ring collider: The weak-strong and the strong-strong pictures. Both pictures play a role in determining the beam-beam behavior. This review addresses only the strong-strong picture. The corresponding beam dynamical effects are referred to as the coherent beam-beam effects. Some basic knowledge of the weak-strong picture is assumed. To be specific, two beams of opposite charges are considered. (orig.)

  4. Beam-beam and impedance

    CERN Document Server

    White, S.

    2014-07-17

    As two counter-rotating beams interact they can give rise to coherent dipole modes. Under the influence of impedance these coherent beam-beam modes can couple to higher order head-tail modes and lead to strong instabilities. A fully self-consistent approach including beam-beam and impedance was used to characterize this new coupled mode instability and study possible cures such as a transverse damper and high chromaticity.

  5. Study of beam-beam long range compensation with octupoles

    CERN Document Server

    AUTHOR|(CDS)2068329; Pieloni, Tatiana; Buffat, Xavier; Tambasco, Claudia

    2017-01-01

    Long range beam-beam effects are responsible for particle losses and define fundamental operational parameters of colliders (i.e. crossing angles, intensities, emittances, ${\\beta}$${^∗}$). In this study we propose octuple magnets as a possible scheme to efficiently compensate long-range beam-beam interactions with a global correction scheme. The impact and improvements on the dynamic aperture of colliding beams together with estimates of the luminosity potentials are dis- cussed for the HL-LHC upgrade and extrapolations made for the FCC project.

  6. Beam-beam studies for FCC-hh

    CERN Document Server

    AUTHOR|(CDS)2068329; Pieloni, Tatiana; Buffat, Xavier; Furuseth, Sondre Vik

    2017-01-01

    The Future Circular Collider hadron-hadron (FCC-hh) design study is currently exploring different IR design possibilities including round and flat optics or different crossing schemes. The present study intends to evaluate each scenario from the beam-beam effects point of view. In particular the single particle long term stability to maximize beam lifetimes and luminosity reach is used to quantify the differences. The impact of strong head on interactions on the beam quality and lifetime is addressed by means of GPU accelerated simulations code featuring a weak-strong 6-dimensional beam-beam interaction.

  7. Beam-Beam Simulations with GUINEA-PIG

    CERN Document Server

    Schulte, Daniel

    1998-01-01

    While the bunches in a linear collider cross only once, due to their small size they experience a strong beam-beam effect. GUINEA-PIG is a code to simulate the impact of this effect on luminosity and back ground. A short overview of the program is given with examples of its application to the back ground strudies for TESLA, the top quark threshold scan and a possible luminosity monitor, as well as some results for CLIC.

  8. Successful Beam-Beam Tuneshift Compensation

    Energy Technology Data Exchange (ETDEWEB)

    Bishofberger, Kip Aaron [Univ. of California, Los Angeles, CA (United States)

    2005-01-01

    The performance of synchrotron colliders has been limited by the beam-beam limit, a maximum tuneshift that colliding bunches could sustain. Due to bunch-to-bunch tune variation and intra-bunch tune spread, larger tuneshifts produce severe emittance growth. Breaking through this constraint has been viewed as impossible for several decades. This dissertation introduces the physics of ultra-relativistic synchrotrons and low-energy electron beams, with emphasis placed on the limits of the Tevatron and the needs of a tuneshift-compensation device. A detailed analysis of the Tevatron Electron Lens (TEL) is given, comparing theoretical models to experimental data whenever possible. Finally, results of Tevatron operations with inclusion of the TEL are presented and analyzed. It is shown that the TEL provides a way to shatter the previously inescapable beam-beam limit.

  9. Beam-beam effects in the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Shiltsev, V.; Alexahin, Y.; Lebedev, V.; Lebrun, P.; Moore, R.S.; Sen, T.; Tollestrup, A.; Valishev, A.; Zhang, X.L.; /Fermilab

    2005-01-01

    The Tevatron in Collider Run II (2001-present) is operating with 6 times more bunches, many times higher beam intensities and luminosities than in Run I (1992-1995). Electromagnetic long-range and head-on interactions of high intensity proton and antiproton beams have been significant sources of beam loss and lifetime limitations. We present observations of the beam-beam phenomena in the Tevatron and results of relevant beam studies. We analyze the data and various methods employed in operations, predict the performance for planned luminosity upgrades, and discuss ways to improve it.

  10. Survey of beam-beam limitations

    International Nuclear Information System (INIS)

    Courant, E.; Cornacchia, M.; Donald, M.M.R.; Evans, L.R.; Tazzari, S.; Wilson, E.J.N.

    1979-01-01

    The effect of beam-beam interaction is known to limit the luminosity of electron-positron storage rings and will, no doubt, limit the proton-antiproton collision scheme for the SPS. While theorists are struggling to explain this phenomenon it is more instructive to list their failures than their rather limited successes, in the hope that experiments may emerge which will direct their endeavors. The search for a description of a nonlinear system as it approaches the limit in which ordered motion breaks down, is the nub of the problem. It has engaged many fine mathematical intellects for decades and will no doubt continue to do so long after ISABELLE, the p antip and LEP are past achievements. Empirical scaling laws are emerging which relate electron machines to each other but their extrapolation to proton machines remain a very speculative exercise. Experimental data on proton limits is confined to one machine, the ISR, which does not normally suffer the beam-beam effect and where it must be artificially induced or simulated. This machine is also very different in important ways from the p antip collider. The gloomy picture which has emerged recently is that the fixed limits which were conventionally assumed for proton and electron machines can only be said to be valid for the machines which engendered them - the best guess that could be made at the time. They are very difficult to extrapolate to other sets of parameters

  11. The impact of gambling advertising: Problem gamblers report stronger impacts on involvement, knowledge, and awareness than recreational gamblers.

    Science.gov (United States)

    Hanss, Daniel; Mentzoni, Rune A; Griffiths, Mark D; Pallesen, Ståle

    2015-06-01

    Although there is a general lack of empirical evidence that advertising influences gambling participation, the regulation of gambling advertising is hotly debated among academic researchers, treatment specialists, lobby groups, regulators, and policymakers. This study contributes to the ongoing debate by investigating perceived impacts of gambling advertising in a sample of gamblers drawn from the general population in Norway (n = 6,034). Three dimensions of advertising impacts were identified, representing perceived impacts on (a) gambling-related attitudes, interest, and behavior ("involvement"); (b) knowledge about gambling options and providers ("knowledge"); and (c) the degree to which people are aware of gambling advertising ("awareness"). Overall, impacts were strongest for the knowledge dimension, and, for all 3 dimensions, the impact increased with level of advertising exposure. Those identified as problem gamblers in the sample (n = 57) reported advertising impacts concerning involvement more than recreational gamblers, and this finding was not attributable to differences in advertising exposure. Additionally, younger gamblers reported stronger impacts on involvement and knowledge but were less likely to agree that they were aware of gambling advertising than older gamblers. Male gamblers were more likely than female gamblers to report stronger impacts on both involvement and knowledge. These findings are discussed with regard to existing research on gambling advertising as well as their implications for future research and policy-making. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  12. Weak-strong Beam-beam Simulations for HL-LHC

    Energy Technology Data Exchange (ETDEWEB)

    Banfi, Danilo [Ecole Polytechnique, Lausanne; Barranco, Javier [Ecole Polytechnique, Lausanne; Pieloni, Tatiana [CERN; Valishev, Alexander [Fermilab

    2014-07-01

    In this paper we present dynamic aperture studies for possible High Luminosity LHC optics in the presence of beam-beam interactions, crab crossing schemes and magnets multipolar errors. Possible operational scenarios of luminosity leveling by transverse offset and betatron function are also studied and the impact on the beams stability is discussed.

  13. Simulation of Beam-Beam Background at CLIC

    CERN Document Server

    Sailer, Andre

    2010-01-01

    The dense beams used at CLIC to achieve a high luminosity will cause a large amount of background particles through beam-beam interactions. Generator level studies with GuineaPig and full detector simulation studies with an ILD based CLIC detector have been performed to evaluate the amount of beam-beam background hitting the vertex detector.

  14. Simulation of Beam-Beam Background at CLIC

    CERN Document Server

    Sailer, A

    2010-01-01

    The dense beams used at CLIC to achieve a high luminosity will cause a large amount of background particles through beam-beam interactions. Generator level studies with GUINEAPIG and full detector simulation studies with an ILD based CLIC detector have been performed to evaluate the amount of beam-beam back- ground hitting the vertex detector.

  15. Beam-beam simulations: dynamical effects and beam-beam limit for LEP3

    CERN Document Server

    Ohmi, K

    2012-01-01

    Beam-beam simulations are reported for LEP3 and TLEP-H, including a rough tune scan. The results suggest that to achieve the design luminosity in LEP3, 10% higher bunch population may be necessary, while TLEP-H can achieve the design performance without any changes. The simulations indicate that the large synchrotron tune, in conjunction with a large hourglass effect, degrades the luminosity performance. This talk was given at CERN on 4 December 2012.

  16. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, J.

    2005-05-16

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC.

  17. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    International Nuclear Information System (INIS)

    Qiang, J.

    2005-01-01

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC

  18. Beam-beam limit in e+e- circular colliders

    International Nuclear Information System (INIS)

    Ohmi, K.; Tawada, M.; Kamada, S.; Oide, K.; Cai, Y.; Qiang, J.

    2004-01-01

    Beam-beam effects limit the luminosity of circular colliders. Once the bunch population exceeds a threshold, the luminosity increases at a slower rate. This phenomenon is called the beam-beam limit. Onset of the beam-beam limit has been analyzed with various simulation methods based on the weak-strong and strong-strong models. We have observed that an incoherent phenomenon is mainly concerned in the beam-beam limit. The simulation have shown that equilibrium distributions of the two colliding beams are distorted from Gaussians when the luminosity is limited. The beam-beam limit is estimated to be ξ∼0.1 for a B factory with damping time of several thousand turns

  19. Instability of compensated beam-beam collisions

    International Nuclear Information System (INIS)

    Rosenzweig, J.B.; Autin, B.; Chen, Pisin.

    1989-01-01

    The beam-beam disruption phenomena in linear colliders are increasingly seen as a source of serious problems for these machines. A plasma compensation scheme, in which the motion of the plasma electrons in the presence of the colliding beams provides neutralizing charge and current densities, has been proposed and studied. But natural alternative to this scheme is to consider the overlapping of nearly identical high energy e + and e/sup /minus// bunches, and the collision of two such pairs - in other words, collision of two opposing relativistic positronium plasmas. It should be noticed that while the luminosity for all collisions is increased by a factor of four in this scheme, the event rate for e + e/sup /minus// collisions is only increased by a factor of two. The other factor of two corresponds to the addition of e + e + and e/sup /minus//e/sup /minus// collisions to the interaction point. This beam compensation scheme, which has been examined through computer simulation by Balakin and Solyak in the Soviet Union, promises full neutralization of beam charges and currents. These numerical investigations have shown that plasma instabilities exist in this nominally neutral system. Although the implementation of this idea seems technically daunting, the potential benefits (beamstrahlung and disruption suppression, relaxation of final focus system constraints) are such that we should consider the physics of these collisions further. In the remainder of this paper, we theoretically analyze the issues of stability and bunch parameter tolerances in this scheme. 11 refs

  20. Beam-beam observations in the Relativistic Heavy Ion Collider

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y. [Brookhaven National Laboratory (BNL), Upton, NY (United States); Fischer, W. [Brookhaven National Laboratory (BNL), Upton, NY (United States); White, S. [Brookhaven National Laboratory (BNL), Upton, NY (United States)

    2015-06-24

    The Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory has been operating since 2000. Over the past decade, thanks to the continuously increased bunch intensity and reduced β*s at the interaction points, the maximum peak luminosity in the polarized proton operation has been increased by more than two orders of magnitude. In this article, we first present the beam-beam observations in the previous RHIC polarized proton runs. Then we analyze the mechanisms for the beam loss and emittance growth in the presence of beam-beam interaction. The operational challenges and limitations imposed by beam-beam interaction and their remedies are also presented. In the end, we briefly introduce head-on beam-beam compensation with electron lenses in RHIC.

  1. Strong-strong beam-beam simulation on parallel computer

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, Ji

    2004-08-02

    The beam-beam interaction puts a strong limit on the luminosity of the high energy storage ring colliders. At the interaction points, the electromagnetic fields generated by one beam focus or defocus the opposite beam. This can cause beam blowup and a reduction of luminosity. An accurate simulation of the beam-beam interaction is needed to help optimize the luminosity in high energy colliders.

  2. Strong-strong beam-beam simulation on parallel computer

    International Nuclear Information System (INIS)

    Qiang, Ji

    2004-01-01

    The beam-beam interaction puts a strong limit on the luminosity of the high energy storage ring colliders. At the interaction points, the electromagnetic fields generated by one beam focus or defocus the opposite beam. This can cause beam blowup and a reduction of luminosity. An accurate simulation of the beam-beam interaction is needed to help optimize the luminosity in high energy colliders

  3. Status of the studies on collective effects involving beam-beam interactions at the HL-LHC

    CERN Document Server

    Buffat, Xavier; Metral, Elias; Ribes Metidieri, Ariadna; Barranco Garcia, Javier; Goncalves Jorge, Patrik; Pieloni, Tatiana; Tambasco, Claudia; CERN. Geneva. ATS Department

    2018-01-01

    This note summarised the status of the studies on the coherent beam-beam effects in the HL-LHC project. It is shown that the obit, tune, chromaticity and dynamic β effects due to head-on and long-range beam-beam interactions are tolerable without dedicated mitigations in the baseline scenario. The stability of coherent beam-beam modes under the influence of the beam coupling impedance is evaluated, as well as the impact of the beam-beam induced tune spread on the Landau damping of single beam head-tail modes of oscillation. Since the beam stability is marginal at the end of the squeeze for the ultimate scenario, it is suggested to use the ATS optics to increase the effect of the octupoles at constant current, thus providing sufficient margins. Measurements suggesting that the transverse damper noise has to be significantly reduced to allow for operation with large beam-beam parameter are shown.

  4. Stronger synergies

    CERN Document Server

    Antonella Del Rosso

    2012-01-01

    CERN was founded 58 years ago under the auspices of UNESCO. Since then, both organisations have grown to become world leaders in their respective fields. The links between the two have always existed but today they are even stronger, with new projects under way to develop a more efficient way of exchanging information and devise a common strategy on topics of mutual interest.   CERN and UNESCO are a perfect example of natural partners: their common field is science and education is one of the pillars on which both are built. Historically, they share a common heritage. Both UNESCO and CERN were born of the desire to use scientific cooperation to rebuild peace and security in the aftermath of the Second World War. "Recently, building on our common roots and in close collaboration with UNESCO, we have been developing more structured links to ensure the continuity of the actions taken over the years," says Maurizio Bona, who is in charge of CERN relations with international orga...

  5. Beam-beam diagnostics from closed-orbit distortion

    Energy Technology Data Exchange (ETDEWEB)

    Furman, M.; Chin, Y.H.; Eden, J. [Lawrence Berkeley Lab., CA (United States); Kozanecki, W. [DAPNIA/SPP, CEN Saclay Gif-sur-Yvette, (FR)]|[Stanford Linear Accelerator Center, Menlo Park, CA (United States); Tennyson, J.; Ziemann, V. [Stanford Linear Accelerator Center, Menlo Park, CA (United States)

    1992-07-01

    We study the applicability of beam-beam deflection techniques as a tuning tool for asymmetric B factories, focusing on PEP-II as an example. Assuming that the closed orbits of the two beams are separated vertically at the interaction point by a local orbit bump that is nominally closed, we calculate the residual beam orbit distortions due to the beam-beam interaction. Difference orbit measurements, performed at points conveniently distant from the interaction point (IP), provide distinct signatures that can be used to maintain the beams in collision and perform detailed optical diagnostics at the IP. A proposal to test this method experimentally at the TRISTAN ring is briefly discussed.

  6. BEAM-BEAM SIMULATIONS FOR DOUBLE-GAUSSIAN BEAMS.

    Energy Technology Data Exchange (ETDEWEB)

    MONTAG, C.; MALITSKY, N.; BEN-ZVI, I.; LITVINENKO, V.

    2005-05-16

    Electron cooling together with intra-beam scattering results in a transverse distribution that can best be described by a sum of two gaussians, one for the high-density core and one for the tails of the distribution. Simulation studies are being performed to understand the beam-beam interaction of these double-gaussian beams. Here we report the effect of low-frequency random tune modulations on diffusion in double-gaussian beams and compare the effects to those in beam-beam interactions with regular gaussian beams and identical tune shift parameters.

  7. BEAM-BEAM SIMULATIONS FOR DOUBLE-GAUSSIAN BEAMS

    International Nuclear Information System (INIS)

    MONTAG, C.; MALITSKY, N.; BEN-ZVI, I.; LITVINENKO, V.

    2005-01-01

    Electron cooling together with intra-beam scattering results in a transverse distribution that can best be described by a sum of two gaussians, one for the high-density core and one for the tails of the distribution. Simulation studies are being performed to understand the beam-beam interaction of these double-gaussian beams. Here we report the effect of loW--frequency random tune modulations on diffusion in double-gaussian beams and compare the effects to those in beam-beam interactions with regular gaussian beams and identical tune shift parameters

  8. Beam-Beam Simulations for Double-Gaussian Beams

    CERN Document Server

    Montag, Christoph; Litvinenko, Vladimir N; Malitsky, Nikolay

    2005-01-01

    Electron cooling together with intra-beam scattering results in a transverse distribution that can best be described by a sum of two Gaussians, one for the high-density core and one for the tails of the distribution. Simulation studies are being performed to understand the beam-beam interaction of these double-Gaussian beams. Here we report the effect of low-frequency random tune modulations on diffusion in double-Gaussian beams and compare the effects to those in beam-beam interactions with regular Gaussian beams and identical tuneshift parameters.

  9. Tevatron beam-beam simulations at injection energy

    Energy Technology Data Exchange (ETDEWEB)

    Meiqin Xiao; Bela Erdelyi; Tanaji Sen

    2003-05-28

    Major issues at Tevatron injection are the effects of 72 long-range beam-beam interactions together with the machine nonlinearity on protons and anti-protons. We look at particle tracking calculations of Dynamic Aperture (DA) under present machine conditions. Comparisons of calculations with observations and experiments are also presented in this report.

  10. Head-On Beam-Beam Interactions in High-Energy Hadron Colliders. GPU-Powered Modelling of Nonlinear Effects

    CERN Document Server

    AUTHOR|(CDS)2160109; Støvneng, Jon Andreas

    2017-08-15

    The performance of high-energy circular hadron colliders, as the Large Hadron Collider, is limited by beam-beam interactions. The strength of the beam-beam interactions will be higher after the upgrade to the High-Luminosity Large Hadron Collider, and also in the next generation of machines, as the Future Circular Hadron Collider. The strongly nonlinear force between the two opposing beams causes diverging Hamiltonians and drives resonances, which can lead to a reduction of the lifetime of the beams. The nonlinearity makes the effect of the force difficult to study analytically, even at first order. Numerical models are therefore needed to evaluate the overall effect of different configurations of the machines. For this thesis, a new code named CABIN (Cuda-Accelerated Beam-beam Interaction) has been developed to study the limitations caused by the impact of strong beam-beam interactions. In particular, the evolution of the beam emittance and beam intensity has been monitored to study the impact quantitatively...

  11. Oxytocin's impact on social face processing is stronger in homosexual than heterosexual men.

    Science.gov (United States)

    Thienel, Matthias; Heinrichs, Markus; Fischer, Stefan; Ott, Volker; Born, Jan; Hallschmid, Manfred

    2014-01-01

    Oxytocin is an evolutionarily highly preserved neuropeptide that contributes to the regulation of social interactions including the processing of facial stimuli. We hypothesized that its improving effect on social approach behavior depends on perceived sexual features and, consequently, on sexual orientation. In 19 homosexual and 18 heterosexual healthy young men, we investigated the acute effect of intranasal oxytocin (24IU) and placebo, respectively, on the processing of social stimuli as assessed by ratings of trustworthiness, attractiveness and approachability for male and female faces. Faces were each presented with a neutral, a happy, and an angry expression, respectively. In heterosexual subjects, the effect of oxytocin administration was restricted to a decrease in ratings of trustworthiness for angry female faces (poxytocin administration robustly increased ratings of attractiveness and approachability for male faces regardless of the facial expression (all p ≤ 0.05), as well as ratings of approachability for happy female faces (poxytocin's enhancing impact on social approach tendencies, suggesting that differences in sexual orientation imply differential oxytocinergic signaling. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Applications of electron lenses: scraping of high-power beams, beam-beam compensation, and nonlinear optics

    Energy Technology Data Exchange (ETDEWEB)

    Stancari, Giulio

    2014-09-11

    Electron lenses are pulsed, magnetically confined electron beams whose current-density profile is shaped to obtain the desired effect on the circulating beam. Electron lenses were used in the Fermilab Tevatron collider for bunch-by-bunch compensation of long-range beam-beam tune shifts, for removal of uncaptured particles in the abort gap, for preliminary experiments on head-on beam-beam compensation, and for the demonstration of halo scraping with hollow electron beams. Electron lenses for beam-beam compensation are being commissioned in the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory (BNL). Hollow electron beam collimation and halo control were studied as an option to complement the collimation system for the upgrades of the Large Hadron Collider (LHC) at CERN; a conceptual design was recently completed. Because of their electric charge and the absence of materials close to the proton beam, electron lenses may also provide an alternative to wires for long-range beam-beam compensation in LHC luminosity upgrade scenarios with small crossing angles. At Fermilab, we are planning to install an electron lens in the Integrable Optics Test Accelerator (IOTA, a 40-m ring for 150-MeV electrons) as one of the proof-of-principle implementations of nonlinear integrable optics to achieve large tune spreads and more stable beams without loss of dynamic aperture.

  13. Overview of Beam-Beam Effects in the Tevatron

    CERN Document Server

    Shiltsev, V.

    2014-01-01

    For almost a quarter of a century the Tevatron proton-antiproton collider was the centrepiece of the world's high-energy physics program, from the start of operation in December 1985 until it was overtaken by the LHC in 2011. The initial design luminosity of the Tevatron was 1030 cm-2 s-1; however, as a result of two decades of upgrades, the accelerator has been able to deliver 430-times higher luminosities to each of two high-luminosity experiments, Collider Detector at Fermilab (CDF) and D0. On the way to record high luminosities, many issues related to the electromagnetic beam-beam interaction of colliding beams have been addressed. Below we present a short overview of the beam-beam effects in the Tevatron.

  14. Closed orbit distortion and the beam-beam interaction

    Energy Technology Data Exchange (ETDEWEB)

    Furman, M.; Chin, Y.H.; Eden, J. [Lawrence Berkeley Lab., CA (United States); Kozanecki, W. [CEA Centre d`Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)]|[Stanford Linear Accelerator Center, Menlo Park, CA (United States); Tennyson, J.; Ziemann, V. [Stanford Linear Accelerator Center, Menlo Park, CA (United States)

    1992-06-01

    We study the applicability of beam-beam deflection techniques as a tuning tool for the SLAC/LBL/LLNL B factory, PEP-II. Assuming that the closed orbits of the two beams are separated vertically at the interaction point by a local orbit bump that is nominally closed, we calculate the residual beam orbit distortions due to the beam-beam interaction. Difference orbit measurements, performed at points conveniently distant from the IP, provide distinct coordinate- or frequency-space signatures that can be used to maintain the beams in collision and perform detailed optical diagnostics at the IP. A proposal to test this method experimentally at the TRISTAN ring is briefly discussed.

  15. 6D beam-beam interaction step-by-step

    CERN Document Server

    Iadarola, Giovanni; Papaphilippou, Yannis; CERN. Geneva. ATS Department

    2017-01-01

    This document describes in detail the numerical method used in different simulation codes for the simulation of beam-beam interactions using the “Synchro Beam Mapping” approach, in order to correctly model the coupling introduced by beam-beam between the longitudinal and the transverse plane. The goal is to provide in a compact, complete and self-consistent manner the set of equations needed for the implementation in a numerical code. The effect of a “crossing angle” in an arbitrary “crossing plane” with respect to the assigned reference frame is taken into account with a suitable coordinate transformation. The employed description of the strong beam allows correctly accounting for the hour-glass effect as well as for linear coupling at the interaction point.

  16. Transverse equilibria in linear collider beam-beam collisions

    International Nuclear Information System (INIS)

    Rosenzweig, J.B.; Chen, Pisin

    1991-01-01

    It has been observed in simulations of the beam-beam interaction in linear colliders that a near equilibrium pinched state of the colliding beams develops when the disruption parameter is large (D much-gt 1). In this state the beam transverse density distributions are peaked at center, with long tails. The authors present here an analytical model of the equilibrium approached by the beams, that of a generalized Bennett pinch which develops through collisionless damping due to the strong nonlinearity of the beam-beam interaction. In order to calculate the equilibrium pinched beam size, an estimation of the rms emittance growth is made which takes into account the partial adiabaticity of the collision. This pinched beam size is used to derive the luminosity enhancement factors whose scaling is in agreement with the simulation results for both D and thermal factor A = σ z /β * large, and explains the previously noted cubic relationship between round and flat beam enhancement factors

  17. Coherent Beam-Beam Effects in the LHC

    CERN Document Server

    Alexahin, Yu I; Herr, Werner; Zorzano-Mier, M P

    2001-01-01

    In the Large Hadron Collider (LHC) two proton beams of similar intensities collide in several interaction points. It is well known that the head-on collision of two beams of equal strength can excite coherent modes whose frequencies are separated from the incoherent spectrum of oscillations of individual particles. This can lead to the loss of Landau damping and possibly to unstable motion. The beam-beam effect in the LHC is further complicated by a large number of bunches (2808 per beam), a finite crossing angle and gaps in the bunch train. The coherent beam-beam effects under various conditions and operational scenarios are studied analytically and with multiparticle simulations. We give an overview of the main results and present proposals to overcome these difficulties together with possible side effects.

  18. Beam-beam synchrobetatron resonance at the LHC

    CERN Document Server

    OHMI, K

    2012-01-01

    Some beam-beam simulations are presented for the LHC beam parameters of late 2012, with collisions at nonzero crossing angle in IPs 1 and 5. Long-range encounters and other IPs are not included. Strong emittance growth is observed above 3the -rd order resonance. Synchrotron motion and z dependent beam-beam force, in particular the nonzero crossing angle, are essential ingredients for this growth. Bunch shortening is observed simultaenously with the strong transverse emittance growth, which is consistent with LHC observations in November 2012. The simulations do not show any significant growth close to the 7-th order resonance ~0.29. The simulated bunch shortening at 3Qy~1is sensitive to Qx. Open questions are if the tune of some bunches may exceed 0.33 in LHC, and/or whether electron cloud also contributes to the phenomenon. This presentation was given at CERN on 4 December 2012.

  19. Energy transparency and symmetries in the beam-beam interaction

    Directory of Open Access Journals (Sweden)

    S. Krishnagopal

    2000-02-01

    Full Text Available We have modified the beam-beam simulation code CBI to handle asymmetric beams and used it to look at energy transparency and symmetries in the beam-beam interaction. We find that even a small violation of energy transparency, or of the symmetry between the two beams, changes the character of the collective (coherent motion; in particular, period-n oscillations are no longer seen. We speculate that the one-time observation of these oscillations at LEP, and the more ubiquitous observation of the flip-flop instability in colliders around the world, may be a consequence of breaking the symmetry between the electron and positron beams. We also apply this code to the asymmetric collider PEP-II, and find that for the nominal parameters of PEP-II, in particular, the nominal tune-shift parameter of ξ_{0}=0.03, there are no collective beam-beam issues. Collective quadrupole motion sets in only at ξ_{0}=0.06 and above, consistent with earlier observations for symmetric beams.

  20. Observations and open questions in beam-beam interactions

    International Nuclear Information System (INIS)

    Sen, Tanaji

    2010-01-01

    The first of the hadron colliders, ISR, started operation in 1970. In the following years, the hadron colliders to follow were the SPS (started 1980), the Tevatron (started 1987 first as a fixed target machine), RHIC (started 2000) and most recently the LHC, which started in 2008. HERA was a hybrid that collided electrons and protons. All of these accelerators had or have their performance limited by the effects of the beam-beam interactions. That has also been true for the electron-positron colliders such as LEP, CESR, KEKB and PEPII. In this article I will discuss how the beam-beam limitations arose in some of these machines. The discussion will be focused on common themes that span the different colliders. I will mostly discuss the hadron colliders but sometimes discuss the lepton colliders where relevant. Only a handful of common accelerator physics topics are chosen here, the list is not meant to be exhaustive. A comparative review of beam-beam performance in the ISR, SPS and Tevatron (ca 1989) can be found in reference. Table 1 shows the relevant parameters of colliders (excluding the LHC), which have accelerated protons.

  1. OBSERVATION OF STRONG - STRONG AND OTHER BEAM - BEAM EFFECTS IN RHIC

    International Nuclear Information System (INIS)

    FISCHER, W.; BLASKIEWICZ, M.; BRENNAN, J.M.; CAMERON, P.; CONNOLLY, R.; MONTAG, C.; PEGGS, S.; PILAT, F.; PTITSYN, V.; TEPIKIAN, S.; TRBOJEVIC, D.; VAN ZEIJTS, J.

    2003-01-01

    RHIC is currently the only hadron collider in which strong-strong beam-beam effects can be seen. For the first time, coherent beam-beam modes were observed in a bunched beam hadron collider. Other beam-beam effects in RHIC were observed in operation and in dedicated experiments with gold ions, deuterons and protons. Observations include measurements of beam-beam induced tune shifts, lifetime and emittance growth measurements with and without beam-beam interaction, and background rates as a function of tunes. During ramps unequal radio frequencies in the two rings cause the crossing points to move longitudinally. Thus bunches experience beam-beam interactions only in intervals and the tunes are modulated. In this article we summarize the most important beam-beam observations made so far

  2. A Symplectic Beam-Beam Interaction with Energy Change

    Energy Technology Data Exchange (ETDEWEB)

    Moshammer, Herbert

    2003-07-14

    The performance of many colliding storage rings is limited by the beam-beam interaction. A particle feels a nonlinear force produced by the encountering bunch at the collision. This beam-beam force acts mainly in the transverse directions so that the longitudinal effects have scarcely been studied, except for the cases of a collision with a crossing angle. Recently, however, high luminosity machines are being considered where the beams are focused extensively at the interaction point (IP) so that the beam sizes can vary significantly within the bunch length. Krishnagopal and Siemann have shown that they should not neglect the bunch length effect in this case. The transverse kick depends on the longitudinal position as well as on the transverse position. If they include this effect, however, from the action-reaction principle, they should expect, at the same time, an energy change which depends on the transverse coordinates. Such an effect is reasonably understood from the fact that the beam-beam force is partly due to the electric field, which can change the energy. The action-reaction principle comes from the symplecticity of the reaction: the electromagnetic influence on a particle is described by a Hamiltonian. The symplecticity is one of the most fundamental requirements when studying the beam dynamics. A nonsymplectic approximation can easily lead to unphysical results. In this paper, they propose a simple, approximately but symplectic mapping for the beam-beam interaction which includes the energy change as well as the bunch-length effect. In the next section, they propose the mapping in a Hamiltonian form, which directly assures its symplecticity. Then in section 3, they study the nature of the mapping by interpreting its consequences. The mapping itself is quite general and can be applied to any distribution function. They show in Section 4 how it appears when the distribution function is a Gaussian in transverse directions. The mapping is applied to the

  3. Spin Depolarization due to Beam-Beam Interaction in NLC

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Kathleen A

    2001-01-04

    Calculations of spin depolarization effects due to the beam-beam interaction are presented for several NLC designs. The depolarization comes from both classical (Bargmann-Michel-Telegdi precession) and quantum (Sokolov-Ternov spin-flip) effects. It is anticipated that some physics experiments at future colliders will require a knowledge of the polarization to better than 0.5% precision. We compare the results of CAIN simulations with the analytic estimates of Yokoya and Chen for head-on collisions. We also study the effects of transverse offsets and beamstrahlung-induced energy spread.

  4. Beam-beam collisions and crossing angles in RHIC

    International Nuclear Information System (INIS)

    Peggs, S.

    1999-01-01

    This paper evaluates the strength of head on and parasitic beam-beam collisions in RHIC when the crossing angle is zero. A non-zero crossing angle is not required in normal operation with 120 bunches, thanks to the early separation of the two beams. The RHIC lattice is shown to easily accommodate even conservatively large crossing angles, for example in beam dynamics studies, or in future operational upgrades to as many as 360 bunches per ring. A modest loss in luminosity is incurred when gold ions collide at an angle after 10 hours of storage

  5. Beam-beam tails simulation for KEK B-factory

    International Nuclear Information System (INIS)

    Shatilov, D.

    1996-12-01

    The special tracking technique is applied for investigation of the beam-beam interaction for KEK B-factory with a crossing angle at the IP. This technique allows us to save a lot of CPU time while simulating the beam tails. The detailed comparison with the brute force tracking code has been performed in order to confirm the validity of the technique. After that, some simulation results for KEKB are presented, which have shown that, in spite of synchro-betatron resonances induced by a crossing angle at the IP, the beam halo growing is quite acceptable. (author)

  6. Beam-beam simulation of Möbius-modified CESR

    Science.gov (United States)

    Talman, R.; Malitsky, N.; Koyama, T.

    1997-05-01

    Colliding beam experiments at CESR with beams made round by running on the coupling resonance have been performed,(E. Young et al.), abstract, this conference and runs are planned with the beams made round by Möbius modification.(R. Talman, Phys. Rev. Lett. 74), 1590, (1995) Performance in these configurations has been simulated using TEAPOT++ tracking, map generation, stochastic, and beam-beam modules within the Unified Accelerator Libraries(N. Malitsky et al.), abstract, this conference The true CESR lattice including sextupoles and element apertures is used. Outputs from the calculation include beam profile modification, tune optimization, maximum luminosity, and (with extrapolation) beam lifetimes.

  7. Limitations due to strong head-on beam-beam interactions (MD 1434)

    CERN Document Server

    Buffat, Xavier; Iadarola, Giovanni; Papadopoulou, Parthena Stefania; Papaphilippou, Yannis; Pellegrini, Dario; Pojer, Mirko; Crockford, Guy; Salvachua Ferrando, Belen Maria; Trad, Georges; Barranco Garcia, Javier; Pieloni, Tatiana; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    The results of an experiment aiming at probing the limitations due to strong head on beam-beam interactions are reported. It is shown that the loss rates significantly increase when moving the working point up and down the diagonal, possibly due to effects of the 10th and/or 14th order resonances. Those limitations are tighter for bunches with larger beam-beam parameters, a maximum total beam-beam tune shift just below 0.02 could be reached.

  8. Experimental observations and theoretical models for beam-beam phenomena

    International Nuclear Information System (INIS)

    Kheifets, S.

    1981-03-01

    The beam-beam interaction in storage rings exhibits all the characteristics of nonintegrable dynamical systems. Here one finds all kinds of resonances, closed orbits, stable and unstable fixed points, stochastic layers, chaotic behavior, diffusion, etc. The storage ring itself being an expensive device nevertheless while constructed and put into operation presents a good opportunity of experimentally studying the long-time behavior of both conservative (proton machines) and nonconservative (electron machines) dynamical systems - the number of bunch-bunch interactions routinely reaches values of 10 10 -10 11 and could be increased by decreasing the beam current. At the same time the beam-beam interaction puts practical limits for the yield of the storage ring. This phenomenon not only determines the design value of main storage ring parameters (luminosity, space charge parameters, beam current), but also in fact prevents many of the existing storage rings from achieving design parameters. Hence, the problem has great practical importance along with its enormous theoretical interest. A brief overview of the problem is presented

  9. Coherent Beam-Beam Oscillations at the LHC

    CERN Document Server

    Zorzano-Mier, M P

    1999-01-01

    The transverse coherent motion of the two colliding LHC beams is studied by multi-particle tracking, where the beam-beam force is calculated assuming a Gaussian beam distribution with variable barycentres and rms beam sizes. The simulation yields the coherent and incoherent oscillation frequencies, the emittance growth of either beam, and evidence for the existence or lack of Landau damping. The transverse beam sizes change with the fractional part of the tune as expected from the dynamic beta effect. For head-on collisions, we find that the pi-mode frequency lies outside of the continuum frequency spread if the ratio of the beam-beam parameters exceeds 0.6, in accordance with predictions [1]. For smaller ratios, the pi-mode is Landau damped. When long range interactions are also included, undamped coherent modes do still exist outside the continuum, both with and without alternating crossing planes at two interaction points. However, the simulation shows that separating the tunes of the two beams can restore...

  10. Exact suppression of depolarisation by beam-beam interaction in an electron ring

    International Nuclear Information System (INIS)

    Buon, J.

    1983-03-01

    It is shown that depolarisation due to beam-beam interaction can be exactly suppressed in an electron storage ring. The necessary ''spin matching'' conditions to be fulfilled are derived for a planar ring. They depend on the ring optics, assumed linear, but not on the features of the beam-beam force, like intensity and non-linearity. Extension to a ring equipped with 90 0 spin rotators is straightorward

  11. Dominance has a biogeographical component: do plants tend to exert stronger impacts in their invaded rather than native range?

    Czech Academy of Sciences Publication Activity Database

    Hejda, Martin; Štajerová, Kateřina; Pyšek, Petr

    2017-01-01

    Roč. 44, č. 1 (2017), s. 18-27 ISSN 0305-0270 R&D Projects: GA ČR(CZ) GAP505/11/1112 Grant - others:AV ČR(CZ) AP1002 Program:Akademická prémie - Praemium Academiae Institutional support: RVO:67985939 Keywords : dominance * biogeographic approach * invasion Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 4.248, year: 2016

  12. Development of Enriched Core Competencies for Health Services and Policy Research: Training for Stronger Career Readiness and Greater Impact.

    Science.gov (United States)

    Bornstein, Stephen; Heritage, Melissa; Chudak, Amanda; Tamblyn, Robyn; McMahon, Meghan; Brown, Adalsteinn

    2018-03-11

    To develop an enriched set of core competencies for health services and policy research (HSPR) doctoral training that will help graduates maximize their impact across a range of academic and nonacademic work environments and roles. Data were obtained from multiple sources, including literature reviews, key informant interviews, stakeholder consultations, and Expert Working Group (EWG) meetings between January 2015 and March 2016. The study setting is Canada. The study used qualitative methods and an iterative development process with significant stakeholder engagement throughout. The literature reviews, key informant interviews, existing data on graduate career trajectories, and EWG deliberations informed the identification of career profiles for HSPR graduates and the competencies required to succeed in these roles. Stakeholder consultations were held to vet, refine, and validate the competencies. The EWG reached consensus on six sectors and eight primary roles in which HSPR doctoral graduates can bring value to employers and the health system. Additionally, 10 core competencies were identified that should be included or further emphasized in the training of HSPR doctoral students to increase their preparedness and potential for impact in a variety of roles within and outside of traditional academic workplaces. The results offer an expanded view of potential career paths for HSPR doctoral graduates and provide recommendations for an expanded set of core competencies that will better equip graduates to maximize their impact on the health system. © Health Research and Educational Trust.

  13. Observations and measurements of dynamic effects due to beam-beam interactions in the LHC and extrapolation to the FCC-hh

    CERN Document Server

    Goncalves Jorge, Patrik

    The Future Circular hadron-hadron Collider (FCC-hh) is a design study for a 100 TeV centre-of-mass energy. The dynamics of the beams in such a collider poses many challenges, in particular the amount of energy stored in each beam (8.4 GJ) makes them very destructive and therefore requires a tight control of the machine and beam parameters during the full cycle in order to avoid damages and reach the collider designed performances. The FCC-hh features an increase of the beam brightness during the cycle due to the presence of synchrotron radiation damping at high energy. As a result, the electromagnetic forces that the two beams exert on each other, the so-called beam-beam forces, are enhanced and might become an issue for the safe operation of the machine. In this new regime, the impact of the beam-beam interaction on the optics becomes non-negligible. In this master thesis, for the first time, the impact of the beam-beam interaction on the optics ($\\beta$-beating) is measured in a hadron collider (LHC). The e...

  14. Simulation of Head-on Beam-Beam Limitations in Future High Energy Colliders

    CERN Document Server

    Buffat, Xavier; Florio, Adrien; Pieloni, Tatiana; Tambasco, Claudia

    2016-01-01

    The Future Circular Hadron Collider (FCC-hh) project calls for studies in a new regime of beam-beam interactions. While the emittance damping due to synchrotron radiation is still slower than in past or existing lepton colliders, it is significantly larger than in other hadron colliders. The slow reduction of the emittance is profitable for higher luminosity in term of transverse beam size at the interaction points and also to mitigate long-range beam-beam effects, potentially allowing for a reduction of the crossing angle between the beams during the operation. In such conditions, the strength of head-on beam-beam interactions increases, potentially limiting the beam brightness. 4D weak-strong and strong-strong simulations are performed in order to assess these limitations.

  15. The beam-beam limit in asymmetric colliders: Optimization of the B-factory parameter base

    International Nuclear Information System (INIS)

    Tennyson, J.L.

    1990-01-01

    This paper presents a general theory of the beam-beam limit in symmetric and asymmetric lepton ring colliders. It shows how the beam-beam limit in these accelerators affects the maximum attainable luminosity and presents a specific algorithm for parameter base optimization. It is shown that the special problems inherent in asymmetric colliders derive not from the asymmetry, but from the fact that the two beams must be in different rings. Computer simulation experiments are used to demonstrate the various phenomena discussed in the theory

  16. Electron Lens as Beam-Beam Wire Compensator in HL-LHC

    CERN Document Server

    Valishev, A

    2013-01-01

    Current wires are considered for compensation of long-range beam-beam interactions for the High Luminosity upgrade (HL-LHC) of the Large Hadron Collider at CERN. In this note, we demonstrate the advantage of using Electron Lens for this purpose instead of a conventional current-bearing wire.

  17. Simulations of coherent beam-beam modes at the Large Hadron Collider

    CERN Document Server

    Zorzano-Mier, M P

    2000-01-01

    The transverse coherent motion of two colliding proton beams at the Large Hadron Collider is studied by multiparticle tracking. We use the beam-beam force for a Gaussian beam distribution with variable barycenters and rms beam sizes, and optionally include the effect of long-range collisions and external impedance. The simulation yields the coherent and incoherent oscillation frequencies, the emittance growth of either beam, and evidence for the existence or lack of Landau damping. For head-on collisions of beams with equal sizes, we find that the pi -mode frequency lies outside of the continuum frequency spread, if the ratio of the beam-beam parameters exceeds 0.6, in accordance with predictions. For smaller ratios of the beam- beam parameters, or if, for equal beam-beam parameters, the beam sizes are widely different, the pi mode is Landau damped. When long- range collisions are also included, undamped coherent modes do still exist outside the continuum, both with and without alternating crossing planes at ...

  18. Large Scale Beam-beam Simulations for the CERN LHC using Distributed Computing

    CERN Document Server

    Herr, Werner; McIntosh, E; Schmidt, F

    2006-01-01

    We report on a large scale simulation of beam-beam effects for the CERN Large Hadron Collider (LHC). The stability of particles which experience head-on and long-range beam-beam effects was investigated for different optical configurations and machine imperfections. To cover the interesting parameter space required computing resources not available at CERN. The necessary resources were available in the LHC@home project, based on the BOINC platform. At present, this project makes more than 60000 hosts available for distributed computing. We shall discuss our experience using this system during a simulation campaign of more than six months and describe the tools and procedures necessary to ensure consistent results. The results from this extended study are presented and future plans are discussed.

  19. Correction of beam-beam effects in luminosity measurement in the forward region at CLIC

    CERN Document Server

    Lukic, Strahinja

    2013-01-01

    Procedures for correcting the beam-beam effects in luminosity measurement at CLIC at 3 TeV CM energy are described and tested using Monte Carlo simulations: -> Correction of the angular counting loss due to the combined Beamstrahlung and initial-state radiation (ISR) effects, based on the reconstructed velocity of the collision frame of the Bhabha scattering. -> Deconvolution of the luminosity spectrum distortion due to the ISR emission. -> Correction of the counting bias due to the finite calorimeter energy resolution. All procedures were tested by simulation. Bhabha events were generated using BHLUMI, and used in Guinea-PIG to simulate the outgoing momenta of Bhabha particles in the bunch collisions at CLIC. Residual uncertainties after correction are listed in a table in the conclusions. The beam-beam related systematic counting uncertainty in the luminosity peak can be reduced to the order of permille.

  20. Correction of beam-beam effects in luminosity measurement in the forward region at CLIC

    CERN Document Server

    Lukic, Strahinja

    2013-01-01

    Procedures for correcting the beam-beam effects in luminosity measurement at CLIC at 3 TeV CM energy are described and tested using Monte Carlo simulations: - Correction of the angular counting loss due to the combined Beamstrahlung and initial-state radiation (ISR) effects, based on the reconstructed velocity of the collision frame of the Bhabha scattering. - Deconvolution of the luminosity spectrum distortion due to the ISR emission. - Correction of the counting bias due to the finite calorimeter energy resolution. All procedures were tested by simulation. Bhabha events were generated using BHLUMI, and used in Guinea-PIG to simulate the outgoing momenta of Bhabha particles in the bunch collisions at CLIC. Residual uncertainties after correction are listed in a table in the conclusions. The beam-beam related systematic counting uncertainty in the luminosity peak can be reduced to the order of permille.

  1. Analysis of Beam-Beam Kink Instability in a Linac-Ring Electron-Ion Collider

    International Nuclear Information System (INIS)

    V. Lebedev; J. Bisognano; R. Li; B. Yunn

    2001-01-01

    A linac-ring collision scheme was considered in recent proposals of electron-gold colliders (eRHIC) and polarized-electron light-ion colliders (EPIC). The advantages of using an energy-recovered linac for the electron beam is that it avoids the limitation of beam-beam tune shift inherent in a storage ring, pertains good beam quality and easy manipulation of polarization. However, the interaction of the ion beam in the storage ring with the electron beam from the linac acts analogously to a transverse impedance, and can induce unstable behavior of the ion beam similar to the strong head-tail instability. In this paper, this beam-beam kink instability with head-tail effect is analyzed using the linearized Vlasov equation, and the threshold of transverse mode coupling instability is obtained

  2. Detection of coherent beam-beam modes with digitized beam position monitor signals

    CERN Document Server

    Stancari, G.; White, S.M.

    2014-01-01

    A system for bunch-by-bunch detection of transverse proton and antiproton coherent oscillations in the Fermilab Tevatron collider is described. It is based on the signal from a single beam-position monitor located in a region of the ring with large amplitude functions. The signal is digitized over a large number of turns and Fourier-analyzed offline with a dedicated algorithm. To enhance the signal, band-limited noise is applied to the beam for about 1 s. This excitation does not adversely affect the circulating beams even at high luminosities. The device has a response time of a few seconds, a frequency resolution of $1.6\\times 10^{-5}$ in fractional tune, and it is sensitive to oscillation amplitudes of 60 nm. It complements Schottky detectors as a diagnostic tool for tunes, tune spreads, and beam-beam effects. Measurements of coherent mode spectra are presented and compared with models of beam-beam oscillations.

  3. Feasibility study of beam-beam compensation in the Tevatron with wires

    International Nuclear Information System (INIS)

    Sen, Tanaji; Erdelyi, Bela

    2005-01-01

    We explore the possibility of compensating long-range beam-beam interactions in the Tevatron by current carrying wires. Compensation strategies depend on whether the compensation is done close to the interaction or nonlocally, on the aspect ratio of the strong beam and on other details. Strategies for each case have been developed and applied to the Tevatron. We discuss the results of these strategies at injection and collision energy

  4. Renormalization theory of beam-beam interaction in electron-positron colliders

    International Nuclear Information System (INIS)

    Chin, Y.H.

    1989-07-01

    This note is devoted to explaining the essence of the renormalization theory of beam-beam interaction for carrying out analytical calculations of equilibrium particle distributions in electron-positron colliding beam storage rings. Some new numerical examples are presented such as for betatron tune dependence of the rms beam size. The theory shows reasonably good agreements with the results of computer simulations. 5 refs., 6 figs

  5. Beam-Beam Simulation of Crab Cavity White Noise for LHC Upgrade

    CERN Document Server

    Qiang, J; Pieloni, Tatiana; Ohmi, Kazuhito

    2015-01-01

    High luminosity LHC upgrade will improve the luminosity of the current LHC operation by an order of magnitude. Crab cavity as a critical component for compensating luminosity loss from large crossing angle collision and also providing luminosity leveling for the LHC upgrade is being actively pursued. In this paper, we will report on the study of potential effects of the crab cavity white noise errors on the beam luminosity lifetime based on strong-strong beam-beam simulations.

  6. An Alternative High Luminosity LHC with Flat Optics and Long-Range Beam-Beam Compensation

    CERN Document Server

    AUTHOR|(CDS)2070952; Valishev, Aleksander; Shatilov, Dmitry

    2015-01-01

    In the baseline scenario of the High-Luminosity LHC (HL-LHC), the geometric loss of luminosity in the two high luminosity experiments due to collisions with a large crossing angle is recovered by tilting the bunches in the interaction region with the use of crab cavities. A possible backup scenario would rely on a reduced crossing angle together with flat optics (with different horizontal and vertical β∗ values) for the preservation of luminosity performance. However, the reduction of crossing angle coupled with the flat optics significantly enhances the strength of long-range beam-beam interactions. This paper discusses the possibility to mitigate the long-range beam-beam effects by current bearing wire compensators (or e-lens). We develop a new HL-LHC parameter list and analyze it in terms of integrated luminosity performance as compared to the baseline. Further, we evaluate the operational scenarios using numerical simulations of single-particle dynamics with beam-beam effects.

  7. Simulation Studies of Beam-Beam Effects of a Ring-Ring Electron-Ion Collider Based on CEBAF

    Energy Technology Data Exchange (ETDEWEB)

    Yuhong Zhang,Ji Qiang

    2009-05-01

    The collective beam-beam effect can potentially cause a rapid growth of beam sizes and reduce the luminosity of a collider to an unacceptably low level. The ELIC, a proposed ultra high luminosity electron-ion collider based on CEBAF, employs high repetition rate crab crossing colliding beams with very small bunch transverse sizes and very short bunch lengths, and collides them at up to 4 interaction points with strong final focusing. All of these features can make the beam-beam effect challenging. In this paper, we present simulation studies of the beam-beam effect in ELIC using a self-consistent strong-strong beam-beam simulation code developed at Lawrence Berkeley National Laboratory. This simulation study is used for validating the ELIC design and for searching for an optimal parameter set.

  8. Numerical Simulation of Beam-Beam Effects in the Proposed Electron-Ion Colider at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Balsa Terzic, Yuhong Zhang

    2010-05-01

    One key limiting factor to a collider luminosity is beam-beam interactions which usually can cause serious emittance growth of colliding beams and fast reduction of luminosity. Such nonlinear collective beam effect can be a very serious design challenge when the machine parameters are pushed into a new regime. In this paper, we present simulation studies of the beam-beam effect for a medium energy ring-ring electron-ion collider based on CEBAF.

  9. Status of RHIC head-on beam-beam compensation project

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, W.; Anerella, M.; Beebe, E.; Bruno, D.; Gassner, D.M.; Gu, X.; Gupta, R.C.; Hock, J.; Jain, A.K.; Lambiase, R.; Liu, C.; Luo, Y.; Mapes, M.; Montag, C.; Oerter, B.; Okamura, M.; Pikin, A.I.; Raparia, D.; Tan, Y.; Than, R.; Thieberger, P.; Tuozzolo, J.; Zhang, W.

    2011-03-28

    Two electron lenses are under construction for RHIC to partially compensate the head-on beam-beam effect in order to increase both the peak and average luminosities. The final design of the overall system is reported as well as the status of the component design, acquisition, and manufacturing. An overview of the RHIC head-on beam-beam compensation project is given in [1], and more details in [2]. With 2 head-on beam-beam interactions in IP6 and IP8, a third interaction with a low-energy electron beam is added near IP10 to partially compensate the the head-on beam-beam effect. Two electron lenses are under construction, one for each ring. Both will be located in a region common to both beams, but each lens will act only on one beam. With head-on beam-beam compensation up to a factor of two improvement in luminosity is expected together with a polarized source upgrade. The current RHIC polarized proton performance is documented in Ref. [4]. An electron lens (Fig. 1) consists of an DC electron gun, warm solenoids to focus the electron beam during transport, a superconducting main solenoid in which the interaction with the proton beam occurs, steering magnets, a collector, and instrumentation. The main developments in the last year are given below. The experimental program for polarized program at 100 GeV was expected to be finished by the time the electron lenses are commissioned. However, decadal plans by the RHIC experiments STAR and PHENIX show a continuing interest at both 100 GeV and 250 GeV, and a larger proton beam size has been accommodated in the design (Tab. 1). Over the last year beam and lattice parameters were optimized, and RHIC proton lattices are under development for optimized electron lens performance. The effect of the electron lens magnetic structure on the proton beam was evaluated, and found to be correctable. Experiments were done in RHIC and the Tevatron.

  10. Compensation of the long-range beam-beam interactions as a path towards new configurations for the high luminosity LHC

    Directory of Open Access Journals (Sweden)

    Stéphane Fartoukh

    2015-12-01

    Full Text Available Colliding bunch trains in a circular collider demands a certain crossing angle in order to separate the two beams transversely after the collision. The magnitude of this crossing angle is a complicated function of the bunch charge, the number of long-range beam-beam interactions, of β^{*} and type of optics (flat or round, and possible compensation or additive effects between several low-β insertions in the ring depending on the orientation of the crossing plane at each interaction point. About 15 years ago, the use of current bearing wires was proposed at CERN in order to mitigate the long-range beam-beam effects [J. P. Koutchouk, CERN Report No. LHC-Project-Note 223, 2000], therefore offering the possibility to minimize the crossing angle with all the beneficial effects this might have: on the luminosity performance by reducing the need for crab-cavities or lowering their voltage, on the required aperture of the final focus magnets, on the strength of the orbit corrector involved in the crossing bumps, and finally on the heat load and radiation dose deposited in the final focus quadrupoles. In this paper, a semianalytical approach is developed for the compensation of the long-range beam-beam interactions with current wires. This reveals the possibility of achieving optimal correction through a careful adjustment of the aspect ratio of the β functions at the wire position. We consider the baseline luminosity upgrade plan of the Large Hadron Collider (HL-LHC project, and compare it to alternative scenarios, or so-called “configurations,” where modifications are applied to optics, crossing angle, or orientation of the crossing plane in the two low-β insertions of the ring. For all these configurations, the beneficial impact of beam-beam compensation devices is then demonstrated on the tune footprint, the dynamical aperture, and/or the frequency map analysis of the nonlinear beam dynamics as the main figures of merit.

  11. Beam-beam interaction and Pacman effects in the SSC with random nonlinear multipoles

    International Nuclear Information System (INIS)

    Goderre, G.P.; Ohnuma, S.

    1988-01-01

    In order to find the combined effects of beam-beam interaction (head-on and long-range) and random nonlinear multipoles in dipole magnets, transverse tunes and smears have been calculated as a function of oscillation amplitudes. Two types of particles, ''regular'' and ''Pacman,'' have been investigated using a modified version of tracking code TEAPOT. Regular particles experience beam-beam interactions in all four interaction regions (IR's), both head-on and long range, while pacman particles interact with bunches of the other beam in one medium-beta and one low-beta IR's only. The model for the beam-beam interaction is of weak-strong type and the strong beam is assumed to have a round Gaussian charge distribution. Furthermore, it is assumed that the vertical closed orbit deviation arising from the finite crossing angle of 70 μrad is perfectly compensated for regular particles. The same compensation applied to pacman particles creates a closed orbit distortion. Linear tunes are adjusted for regular particles to the design values but there are no nonlinear corrections except for chromaticity correcting sextupoles in two families. Results obtained in this study do not show any reduction of dynamic or linear aperture for pacman particles but some doubts exist regarding the validity of defining the linear aperture from the smear alone. Preliminary results are given for regular particles when (Δp/p) is modulated by the synchrotron oscillation. For these, fifty oscillations corresponding to 26,350 revolutions have been tracked. A very slow increase in the horizontal amplitude, /approximately/4 /times/ 10/sup /minus/4//oscillation (relative), is a possibility but this should be confirmed by trackings of larger number of revolutions. 11 refs., 18 figs., 2 tabs

  12. Beam-beam instability driven by wakefield effects in linear colliders

    CERN Document Server

    Brinkmann, R; Schulte, Daniel

    2002-01-01

    The vertical beam profile distortions induced by wakefield effects in linear colliders (the so-called ``banana effect'') generate a beam-beam instability at the collision point when the vertical disruption parameter is large. We illustrate this effect in the case of the TESLA linear collider project. We specify the tolerance on the associated emittance growth, which translates into tolerances on injection jitter and, for a given tuning procedure, on structure misalignments. We look for possible cures based on fast orbit correction at the interaction point and using a fast luminosity monitor.

  13. Head-on and long-range beam-beam tune shift spread in the SSC

    International Nuclear Information System (INIS)

    Lopez, G.

    1993-01-01

    The head-on and long-range incoherent tune shifts for the Superconducting Super Collider (SSC) are estimated using the numerical integration of the analytical expression coming from the first order in the perturbation strength. The variation of the tune shift as a function of the displacements of the charged particle in the vertical and horizontal planes is studied with the nominal parameters for the SSC. A scaling expression is obtained for the parameters involved in the beam-beam tune shifts, which allows the author to predict the effect in the incoherent tune shift spread under changes in these parameters

  14. Development of a Beam-Beam Simulation Code for e+e- Colliders

    CERN Document Server

    Zhang, Yuan

    2005-01-01

    BEPC will be upgraded into BEPCII, and the luminosity will be about 100 times higher. We developed a three dimensional strong-strong PIC code to study the beam-beam effects in BEPCII. The transportation through the arc is the same as that in Hirata's weak-strong code. The beam-beam force is computed directly by solving the Poisson equation using the FACR method, and the boundary potential is computed by circular convolution. The finite bunch length effect is included by longitudinal slices. An interpolation scheme is used to reduce the required slice number in simulations. The standard message passing interface (MPI) is used to parallelize the code. The computing time increases linearly with (n+1), where n is the slice number. The calculated luminosity of BEPCII at the design operating point is less than the design value. The best area in the tune space is near (0.505,0.57) according to the survey, where the degradation of luminosity can be improved.

  15. Simulating the Wire Compensation of LHC Long-Range Beam-beam Effects.

    CERN Document Server

    Rijoff, T

    2012-01-01

    The performance of the Large Hadron Collider (LHC) and its minimum crossing angle are limited by long-range beam-beam collisions. Wire compensators can mitigate part of the long-range effects. We perform simulations to explore the efficiency of the compensation at possible wire locations by examining the tune footprint and the dynamic aperture. Starting from the weak-strong simulation code BBTrack we developed a new Lyapunov calculation tool, which seems to better diagnose regular or chaotic particle behavior. We also developed faster ways to execute the simulation and the post-processing. These modifications have allowed us to study different wire positions (longitudinal and transverse), varying wire currents, several wire shapes, and a range of beam-beam crossing angles, in view of a prototype wire installation in the LHC foreseen for 2014/15. Our simulations demonstrate that the wire can provide a good compensation, including for reduced crossing angle. Among the benefits of an LHC wire compensator are a b...

  16. Solution of the Fokker-Planck equation with mixing of angular harmonics by beam-beam charge exchange

    International Nuclear Information System (INIS)

    Mikkelsen, D.R.

    1989-09-01

    A method for solving the linear Fokker-Planck equation with anisotropic beam-beam charge exchange loss is presented. The 2-D equation is transformed to a system of coupled 1-D equations which are solved iteratively as independent equations. Although isotropic approximations to the beam-beam losses lead to inaccurate fast ion distributions, typically only a few angular harmonics are needed to include accurately the effect of the beam-beam charge exchange loss on the usual integrals of the fast ion distribution. Consequently, the algorithm converges very rapidly and is much more efficient than a 2-D finite difference method. A convenient recursion formula for the coupling coefficients is given and generalization of the method is discussed. 13 refs., 2 figs

  17. Combined phenomena of beam-beam and beam-electron cloud interactionsin circular e^{+}e^{-} colliders

    Directory of Open Access Journals (Sweden)

    Kazuhito Ohmi

    2002-10-01

    Full Text Available An electron cloud causes various effects in high intensity positron storage rings. The positron beam and the electron cloud can be considered a typical two-stream system with a certain plasma frequency. Beam-beam interaction is another important effect for high luminosity circular colliders. Colliding two beams can be considered as a two-stream system with another plasma frequency. We study the combined phenomena of the beam-electron cloud and beam-beam interactions from a viewpoint of two complex two-stream effects with two plasma frequencies.

  18. Climate and development: enhancing impact through stronger linkages in the implementation of the Paris Agreement and the Sustainable Development Goals (SDGs).

    Science.gov (United States)

    Gomez-Echeverri, Luis

    2018-05-13

    One of the greatest achievements in the global negotiations of 2015 that delivered the 2030 Agenda for Sustainable Development or Sustainable Development Goals (SDGs) and the Paris Agreement on climate change is that, for the first time, the linkages between climate and development were enshrined in each of the documents. This was done in recognition that climate change and development need to be addressed together in order not only to avoid harmful trade-offs and high costs, particularly for poorer countries, but also to exploit the benefits that come from strengthening these linkages. This review presents some of the latest data that argue for stronger linkages as well as the challenges of implementation which are not only politically and economically related but also include issues such as knowledge gaps, finance and governance. Finally, the review also presents a glimpse at the pathways that will be required to reach the ambitious global temperature targets of the Paris Agreement of less than 2°C above pre-industrial levels with efforts to limit temperature rise even further to 1.5°C. This provides the context for some conclusions and recommendations for policy-makers, including on methodologies for assessing linkages and leveraging them for greater benefit.This article is part of the theme issue 'The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'. © 2018 The Authors.

  19. Effect of a spectrometer magnet on the beam-beam interaction

    International Nuclear Information System (INIS)

    Cornacchia, M.; Parzen, G.

    1981-01-01

    The presence of experimental apparatus in the interaction regions of an intersecting beam accelerator changes the configuration of the crossing beams. This changes the space-charge forces with respect to the standard, magnet-free crossing. The question is: what is the maximum allowable perturbation caused by the spectrometer magnet that can be tolerated from the point of view of the beam dynamics. This paper is limited to the perturbations that the curved trajectories cause the beam-beam space charge nonlinearities. The question has arisen of how one defines the strength of the perturbation. The only solution is to compute the strength of the most important nonlinear resources. In what follows, the computational method used in calculating these resonances is described, and compared with those induced by random orbit errors

  20. Investigation of the flat-beam model of the beam-beam interaction

    Directory of Open Access Journals (Sweden)

    Bjoern S. Schmekel

    2003-10-01

    Full Text Available At the interaction point of a storage ring collider each beam is subject to perturbations due to the electromagnetic field of the counterrotating beam. For flat beams, a well-known approximation models the beam by a current sheet which is uniform in the horizontal plane, restricting the particle motion to the vertical direction. In this classical model a water-bag beam distribution has been used to find working points and beam-beam tune shift parameters which lead to a stable beam distribution. We investigate the stability of a more realistic Gaussian equilibrium distribution. A linearized Vlasov equation written in action-angle variables is used to compute the radial and angular modes of a perturbation in two-dimensional phase space to first order in the displacement from the design trajectory. We find that the radial modes, which are often neglected, can have a stabilizing effect on the beam motion.

  1. Testing long range beam-beam compensation for the LHC luminosity upgrade

    CERN Document Server

    Rijoff, Tatiana; Caracciolo, Sergio

    The performance of the Large Hadron Collider (LHC) at CERN and its minimum crossing angle are limited by long-range beam-beam collisions. A wire compensators can mitigate part of the long-range effects and may allow for smaller crossing angles, or higher beam intensity. A prototype long-range wire compensator should be installed in the LHC by 2014/15. The originally reserved position for the wire compensator (named BBC) seems not available in this first step, we need so to test other possibilities. The performed tests consider various longitudinal and transverse locations, different wire shapes, different optics configuration and trying several crossing angles between the beam. Simulation are done with the weak-strong code BBtrack developed by U. Dorda. New postprocessing tools were used to analyse tune footprints and particle stability In particular for particle stability was implemented a new method for the Lyapunov coefficient calculation.

  2. Effect of a spectrometer magnet on the beam-beam interaction

    Energy Technology Data Exchange (ETDEWEB)

    Cornacchia, M; Parzen, G

    1981-01-01

    The presence of experimental apparatus in the interaction regions of an intersecting beam accelerator changes the configuration of the crossing beams. This changes the space-charge forces with respect to the standard, magnet-free crossing. The question is: what is the maximum allowable perturbation caused by the spectrometer magnet that can be tolerated from the point of view of the beam dynamics. This paper is limited to the perturbations that the curved trajectories cause the beam-beam space charge nonlinearities. The question has arisen of how one defines the strength of the perturbation. The only solution is to compute the strength of the most important nonlinear resources. In what follows, the computational method used in calculating these resonances is described, and compared with those induced by random orbit errors.

  3. Beam-beam interaction and pacman effects in the SSC with momentum oscillation

    International Nuclear Information System (INIS)

    Mahale, N.K.; Ohnuma, S.

    1989-01-01

    In order to find the combined effects of beam-beam interaction (head-on and long-range) and random nonlinear multipoles in dipole magnets, the transverse oscillations of ''regular'' as well as ''pacman'' particles are traced for 256 synchrotron oscillation periods (corresponding to 135K revolutions) in the proposed SSC. Results obtained in this study do not show any obvious reduction of dynamic or linear apertures for pacman particles when compared with regular particles for (Δp/p) = 0. There are some indications of possible sudden or gradual increases in the oscillation amplitude, for pacman as well as regular particles, when the amplitude of momentum oscillation is as large as 3σ. 4 refs., 7 figs

  4. Testing Long-Range Beam-Beam Compensation for the LHC Luminosity Upgrade

    CERN Document Server

    Rijoff, T L

    2012-01-01

    The performance of the Large Hadron Collider (LHC) at CERN and its minimum crossing angle are limited by the effect of long-range beam-beam collisions. A wire compensators can mitigate part of the long-range effects and may allow for smaller crossing angles, or higher beam intensity. A prototype long-range wire compensator could be installed in the LHC by 2014/15. Since the originally reserved position for such a wire compensator is not available for this first step, we explore other possible options. Our investigations consider various longitudinal and transverse locations, different wire shapes, different optics configurations and several crossing angles between the two colliding beams. Simulations are carried out with the weak-strong code BBtrack. New postprocessing tools are introduced to analyse tune footprints and particle stability. In particular, a new method for the Lyapunov coefficient calculation is implemented. Submitted as "Tesi di laurea" at the University of Milano, 2012.

  5. Symmetrization of the beam-beam interaction in an asymmetric collider

    International Nuclear Information System (INIS)

    Chin, Y.H.

    1990-07-01

    This paper studies the idea of symmetrizing both the lattice and the beams of an asymmetric collider, and discusses why this regime should be within the parametric reach of the design in order to credibly ensure its performance. Also examined is the effectiveness of a simple compensation method using the emittance as a free parameter and that it does not work in all cases. At present, when there are no existing asymmetric colliders, it seems prudent to design an asymmetric collider so as to be similar to a symmetric one (without relying on a particular theory of the asymmetric beam-beam interaction that has not passed tests of fidelity). Nevertheless, one must allow for the maximum possible flexibility and freedom in adjusting those parameters that affect luminosity. Such a parameter flexibility will be essential in tuning the collider to the highest luminosity

  6. Prospects for stronger calandria tubes

    International Nuclear Information System (INIS)

    Ells, C.E.; Coleman, C.E.; Hosbons, R.R.; Ibrahim, E.F.; Doubt, G.L.

    1990-12-01

    The CANDU calandria tubes, made of seam welded and annealed Zircaloy-2, have given exemplary service in-reactor. Although not designed as a system pressure containment, calandria tubes may remain intact even in the face of pressure tube rupture. One such incident at Pickering Unit 2 demonstrated the economic advantage of such an outcome, and a case can be made for increasing the probability that other calandria tubes would perform in a similar fashion. Various methods of obtaining stronger calandria tubes are available, and reviewed here. When the tubes are internally pressurized, the weld is the weak section of the tube. Increasing the oxygen concentration in the starting sheet, and thickening the weld, are promising routes to a stronger tube

  7. Compensation of head-on beam-beam induced resonance driving terms and tune spread in the Relativistic Heavy Ion Collider

    Directory of Open Access Journals (Sweden)

    W. Fischer

    2017-09-01

    Full Text Available A head-on beam-beam compensation scheme was implemented for operation in the Relativistic Heavy Ion Collider (RHIC at Brookhaven National Laboratory [Phys. Rev. Lett. 115, 264801 (2015PRLTAO0031-900710.1103/PhysRevLett.115.264801]. The compensation consists of electron lenses for the reduction of the beam-beam induced tune spread, and a lattice for the minimization of beam-beam generated resonance driving terms. We describe the implementations of the lattice and electron lenses, and report on measurements of lattice properties and the effect of the electron lenses on the hadron beam.

  8. Beam-Beam effects at the CMS BRIL van-der-Meer scans

    CERN Document Server

    CMS Collaboration

    2017-01-01

    The CMS Beam Radiation Instrumentation and Luminosity Project (BRIL) is devoted to the simulation and measurement of luminosity, beam conditions and radiation fields in the CMS Experiment at CERN. The project is engaged in operating and developing new detectors, compatible with the high luminosity experimental environments at the LHC. BRIL operates several detectors based on different physical principles and technologies. The detectors are calibrated using van-der-Meer scans to measure the luminosity that is a fundamental quantity of the LHC beam. In van-der-Meer scans the count rate in a detector is measured as a function of the distance between beams in the plane perpendicular to beam direction, to extract the underlying beam overlap area. The goal of the van-der-Meer scans is to obtain the calibration constant for each luminometer to be used at calibration then in physics data taking runs. The note presents the overview of beam-beam effects at the van-der-Meer scan and the corresponding corrections that sh...

  9. Progress with Long-Range Beam-Beam Compensation Studies for High Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Adriana; et al.

    2017-05-01

    Long-range beam-beam (LRBB) interactions can be a source of emittance growth and beam losses in the LHC during physics and will become even more relevant with the smaller '* and higher bunch intensities foreseen for the High Luminosity LHC upgrade (HL-LHC), in particular if operated without crab cavities. Both beam losses and emittance growth could be mitigated by compensat-ing the non-linear LRBB kick with a correctly placed current carrying wire. Such a compensation scheme is currently being studied in the LHC through a demonstration test using current-bearing wires embedded into col-limator jaws, installed either side of the high luminosity interaction regions. For HL-LHC two options are considered, a current-bearing wire as for the demonstrator, or electron lenses, as the ideal distance between the particle beam and compensating current may be too small to allow the use of solid materials. This paper reports on the ongoing activities for both options, covering the progress of the wire-in-jaw collimators, the foreseen LRBB experiments at the LHC, and first considerations for the design of the electron lenses to ultimately replace material wires for HL-LHC.

  10. RF Wire Compensator of Long-Range Beam-Beam Effects

    CERN Document Server

    Dorda, U; Kroyer, T; Zimmermann, F

    2008-01-01

    The dynamic aperture of the proton beam circulating in the Large Hadron Collider (LHC) is expected to be limited by up to 120 long-range beam-beam encounters. In order to perfectly compensate the LHC long-range beambeam effect for nominal as well as for so-called "PACMAN" bunches, i.e. bunches at the start or end of a bunch train, the strength of a wire compensator should be adjusted for each bunch individually. Here an RF-based compensator is proposed as a practical solution for the PACMAN compensation. We show that this approach also allows relaxing the power and precision requirements compared with those of a pulsed DC device, to a level within the state-of-the-art of RF technology. Furthermore it permits the use of a passive circulator in the tunnel close to the beam and thus a significant reduction of the transmission line length and of the associated multiple reflections. Simulations of dynamic aperture and emittance growth, issues related to RF phase noise, and first experimental results from laborator...

  11. Correction of beam-beam effects in luminosity measurement at ILC

    CERN Document Server

    Lukic, S

    2015-01-01

    Three methods for handling beam-beam effects in luminosity measurement at ILC are tested and evaluated in this work. The first method represents an optimization of the LEPtype asymmetric selection cuts that reduce the counting biases. The second method uses the experimentally reconstructed shape of the √ s ′ spectrum to determine the Beamstrahlung component of the bias. The last, recently proposed, collision-frame method relies on the reconstruction of the collision-frame velocity to define the selection function in the collision frame both in experiment and in theory. Thus the luminosity expression is insensitive to the difference between the CM frame of the collision and the lab frame. The collision-frame method is independent of the knowledge of the beam parameters, and it allows an accurate reconstruction of the luminosity spectrum above 80% of the nominal CM energy. However, it gives no precise infromation about luminosity below 80% of the nominal CM energy. The compatibility of diverse selection cut...

  12. Faster-higher-stronger -- greener

    International Nuclear Information System (INIS)

    Burgess, A.

    2000-01-01

    The Toronto Olympic Bid Committee is reported to have adopted a strong environmental orientation in its bid to bring the 2008 Olympic Games to Toronto. In a recent address, the President of the Committee outlined details of the bid's environmental component which emphasizes the role of sustainable development within the Olympics and the consequences of this orientation on the design, construction and operation of facilities. The Toronto Bid Committee has gained inspiration and momentum for its 'green bid' from the host city of the 2000 Olympic Games, Sidney, Australia, which has won widespread praise for its efforts to clean up Homebush Bay, a brownfield site long seen as a liability for the city. The Toronto Bid Committee is making itself accountable for: creating the healthiest possible conditions for the athletes, visitors and residents; designing for sustainability; protecting, restoring and enhancing human and natural habitats; conserving resources and minimizing the ecological impact of the Games; promoting innovative, technically proven Canadian environmental technology; and fostering environmental awareness and education. The Committee intends to make the environment a priority and not just an afterthought in the bidding process. It hopes to develop specific goals and where possible, quantifiable targets in non-polluting designs for all Olympic housing and sports facilities. Wherever possible renewable power such as wind, solar and fuel cells will be used, and cleaner fuels such as natural gas where green power is not a viable option

  13. Fast Poisson Solvers for Self-Consistent Beam-Beam and Space-Charge Field Computation in Multiparticle Tracking Simulations

    CERN Document Server

    Florio, Adrien; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    We present two different approaches to solve the 2-dimensional electrostatic problem with open boundary conditions to be used in fast tracking codes for beam-beam and space charge simulations in high energy accelerators. We compare a fast multipoles method with a hybrid Poisson solver based on the fast Fourier transform and finite differences in polar coordinates. We show that the latter outperforms the first in terms of execution time and precision, allowing for a reduction of the noise in the tracking simulation. Furthermore the new algorithm is shown to scale linearly on parallel architectures with shared memory. We conclude by effectively replacing the HFMM by the new Poisson solver in the COMBI code.

  14. Tune distributions and effective tune spread from beam-beam interactions and the consequences for Landau damping in the LHC

    CERN Document Server

    Herr, Werner

    2003-01-01

    We have calculated the tune distribution functions in the presence of beam-beam effects in order to evaluate the efect of Landau damping of instabilities driven by the impedance. The corresponding stability diagrams have been computed and the limits on the transverse impedance have be derived.

  15. Chemical reaction due to stronger Ramachandran interaction

    Indian Academy of Sciences (India)

    The origin of a chemical reaction between two reactant atoms is associated with the activation energy, on the assumption that, high-energy collisions between these atoms, are the ones that overcome the activation energy. Here, we show that a stronger attractive van der Waals (vdW) and electron-ion Coulomb interactions ...

  16. Cross-wake force and correlated head-tail instability in beam-beam collisions with a large crossing angle

    Science.gov (United States)

    Kuroo, Nami; Ohmi, Kazuhito; Oide, Katsunobu; Zhou, Demin; Zimmermann, Frank

    2018-03-01

    This paper discusses novel coherent beam-beam instability in collisions with a large crossing angle. The instability appears in the correlated head-tail motion of two colliding beams. A cross-wake force, which is localized at the collision point, is introduced to represent the head-tail correlation between colliding beams. A mode-coupling theory based on this localized cross-wake force enables us to explain the correlated heal-tail instability. The use of a collision scheme with a large crossing angle is becoming popular in the design of electron-positron colliders. An example thereof is the SuperKEKB project, in which a collision with a large crossing angle is performed to boost the luminosity to 0.8 ×1036 cm-2 s-1 . Future circular colliders will also be designed with a large crossing angle. Strong-strong simulations, which have shown the first coherent head-tail instability, can limit the performance of proposed future colliders. The mechanism whereby this instability occurs is mode coupling due to the cross-wake force. This instability may affect all collider designs based on the crab waist scheme.

  17. Radiation and Background Levels in a CLIC Detector due to Beam-Beam Effects Optimisation of Detector Geometries and Technologies

    CERN Document Server

    Sailer, André; Lohse, Thomas

    2013-01-10

    The high charge density---due to small beam sizes---and the high energy of the proposed CLIC concept for a linear electron--positron collider with a centre-of-mass energy of up to 3~TeV lead to the production of a large number of particles through beam-beam interactions at the interaction point during every bunch crossing (BX). A large fraction of these particles safely leaves the detector. A still significant amount of energy will be deposited in the forward region nonetheless, which will produce secondary particles able to cause background in the detector. Furthermore, some particles will be created with large polar angles and directly cause background in the tracking detectors and calorimeters. The main sources of background in the detector, either directly or indirectly, are the incoherent $mathrm{e}^{+}mathrm{e}^{-}$ pairs and the particles from $gammagamma ightarrow$ hadron events. The background and radiation levels in the detector have to be estimated, to study if a detector is feasible, that can han...

  18. Beam-beam effects in high energy e+e- storage rings: resonant amplification of vertical dimensions for flat beams

    International Nuclear Information System (INIS)

    Bambade, P.

    1984-06-01

    In this thesis, we present a phenomenological study of the beam-beam effect in e + e - storage rings. We are in particular interested in the blow-up of the vertical dimension observed in this kind of accelerator. A detailed analysis of the electromagnetic field generated by the very flat bunches stored, and seen by the counter-rotating particles shows that two-dimensional non-linear resonances, which couple vertical and horizontal betatron oscillations, play a very important role. Moreover, the ''weak beam-strong beam'' approximation holds rather well in the case of very flat bunches. Perturbative analysis enables us to predict the effects from the strongest coupling resonance: 20sub(x)-20sub(y) = integer. We find that mainly the tails of the vertical distribution are affected, and we give a criterion concerning the optimal distance to this resonance in the case of a storage ring such as LEP. Finally, the results and in particular the validity of the single resonance approximation are checked through a numerical simulation [fr

  19. Emittance Growth of the LHC Beam due to the Effect of Head-on Beam-Beam Interaction and Ground Motion

    CERN Document Server

    Sen, T

    2000-01-01

    The influence of ground motion on the LHC beam is estimated by applying the existing theories of particle diffusion due to a weak-strong beam-beam collision with random offset at the interaction point. Noise at odd harmonics of the betatron frequency contributes significantly to particle diffusion. Extrapolating the characteristics of the random offset from the ground motion spectrum at the LHC site shows a fast fall-off with frequency and the amplitude is very small even at the first harmonic. We find that the head-on beam-beam force in the weak-strong approximation and ground motion by themselves do not induce significant diffusion over the lifetime of the beam.

  20. Expected damage to accelerator equipment due to the impact of the full LHC beam: beam instrumentation, experiments and simulations

    CERN Document Server

    Burkart, Florian

    The Large Hadron Collider (LHC) is the biggest and most powerful particle accelerator in the world, designed to collide two proton beams with particle momentum of 7 TeV/c each. The stored energy of 362MJ in each beam is sufficient to melt 500 kg of copper or to evaporate about 300 liter of water. An accidental release of even a small fraction of the beam energy can cause severe damage to accelerator equipment. Reliable machine protection systems are necessary to safely operate the accelerator complex. To design a machine protection system, it is essential to know the damage potential of the stored beam and the consequences in case of a failure. One (catastrophic) failure would be, if the entire beam is lost in the aperture due to a problem with the beam dumping system. This thesis presents the simulation studies, results of a benchmarking experiment, and detailed target investigation, for this failure case. In the experiment, solid copper cylinders were irradiated with the 440GeV proton beam delivered by the ...

  1. LHC Season 2: A stronger machine

    CERN Multimedia

    Dominguez, Daniel

    2015-01-01

    1) New magnets / De nouveaux aimants 2) Stronger connections / Des jonctions électriques renforcées 3) Safer magnets / Des aimants plus sûrs 4) Higher energy beams / Des faisceaux d’énergie plus élevée 5) Narrower beams / Des faisceaux plus serrés 6) Smaller but closer proton packets / Des groupes de protons plus petits mais plus rapprochés 7) Higher voltage / Une tension plus haute 8) Superior cryogenics / Un système cryogénique amélioré 9) Radiation-resistant electronics / Une électronique qui résiste aux radiations 10) More secure vacuum / Un vide plus sûr

  2. Stronger declines in youth alcohol consumption thanks to stronger integrated alcohol policies? A qualitative comparison of ten Dutch municipalities.

    Science.gov (United States)

    de Goeij, Moniek C M; Harting, Janneke; Kunst, Anton E

    2017-03-02

    Little detailed evidence is available on how integrated policies could impact population health and under what conditions such policies could be realized. The aim of this study was to assess how youth alcohol consumption trends in the province of Noord-Brabant, The Netherlands, were related to the development and implementation of integrated policies. In a retrospective multiple case study, alcohol policies of six municipalities with stronger declines in youth alcohol consumption between 2007 and 2011 (cases) were compared to four municipalities with weaker declines (controls). Information on the policy process in the same period was obtained through semi-structured in-depth interviews with policy advisors. Information on implemented interventions was extracted from policy documents and checked by the interviewees. Interviews were analyzed for thematic content. Only municipalities with stronger declines in alcohol consumption involved sectors other than public health and had started to implement interventions that use regulatory or enforcement strategies. Their involvement was facilitated by framing youth alcohol consumption as a safety rather than a health problem, whereby local media played a substantial role. Implementation of integrated policies was further facilitated by dedicated leadership and sufficient resources. Reductions in youth alcohol consumption in Noord-Brabant were stronger when municipalities started to develop integrated policies. Results suggest that integrated policies framing a health problem as a broader societal problem could positively influence population health.

  3. Gas Marbles: Much Stronger than Liquid Marbles

    Science.gov (United States)

    Timounay, Yousra; Pitois, Olivier; Rouyer, Florence

    2017-06-01

    Enwrapping liquid droplets with hydrophobic particles allows the manufacture of so-called "liquid marbles" [Aussillous and Quéré Nature (London) 411, 924 (2001); , 10.1038/35082026Mahadevan Nature (London)411, 895 (2001), 10.1038/35082164]. The recent intensive research devoted to liquid marbles is justified by their very unusual physical and chemical properties and by their potential for various applications, from microreactors to water storage, including water pollution sensors [Bormashenko Curr. Opin. Colloid Interface Sci. 16, 266 (2011), 10.1016/j.cocis.2010.12.002]. Here we demonstrate that this concept can be successfully applied for encapsulating and protecting small gas pockets within an air environment. Similarly to their liquid counterparts, those new soft-matter objects, that we call "gas marbles," can sustain external forces. We show that gas marbles are surprisingly tenfold stronger than liquid marbles and, more importantly, they can sustain both positive and negative pressure differences. This magnified strength is shown to originate from the strong cohesive nature of the shell. Those interesting properties could be exploited for imprisoning valuable or polluted gases or for designing new aerated materials.

  4. Compensation of the long-range beam-beam interactions as a path towards new configurations for the High Luminosity LHC

    CERN Document Server

    AUTHOR|(SzGeCERN)390904; Papaphilippou, Yannis; Shatilov, Dmitry

    2015-01-01

    Colliding bunch trains in a circular collider demands a certain crossing angle in order to separate the two beams transversely after the collision. The magnitude of this crossing angle is a complicated function of the bunch charge, the number of long-range beam-beam interactions, of β* and type of optics (flat or round), and possible compensation or additive effects between several low-β insertions in the ring depending on the orientation of the crossing plane at each interaction point. About 15 years ago, the use of current bearing wires was proposed at CERN in order to mitigate the longrange beam-beam effects, therefore offering the possibility to minimize the crossing angle with all the beneficial effects this might have: on the luminosity performance by reducing the need for crab-cavities or lowering their voltage, on the required aperture of the final focus magnets, on the strength of the orbit corrector involved in the crossing bumps, and finally on the heat load and radiation dose deposited in the fi...

  5. GPU-Powered Modelling of Nonlinear Effects due to Head-On Beam-Beam Interactions in High-Energy Hadron Colliders.

    CERN Document Server

    Furuseth, Sondre

    2017-01-01

    The performance of high-energy circular hadron colliders, as the Large Hadron Collider, is limited by beam-beam interactions. The strongly nonlinear force between the two opposing beams causes diverging Hamiltonians and resonances, which can lead to a reduction of the lifetime of the beams. The nonlinearity makes the effect of the force difficult to study analytically, even at first order. Numerical models are therefore needed to evaluate the overall effect of different configurations of the machines. This report discusses results from an implementation of the weak-strong model, studying the effects of head-on beam-beam interactions. The assumptions has been shown to be valid for configurations where the growth and losses of the beam are small. The tracking has been done using an original code which applies graphic cards to reduce the computation time. The bunches in the beams have been modelled cylindrically symmetrical, based on a Gaussian distribution in three dimensions. This choice fits well with bunches...

  6. States agree on stronger physical protection regime

    International Nuclear Information System (INIS)

    2005-01-01

    Full text: Delegates from 89 countries agreed on 8 July to fundamental changes that will substantially strengthen the Convention on the Physical Protection of Nuclear Material (CPPNM). IAEA Director General Mohamed ElBaradei welcomed the agreement in saying 'This new and stronger treaty is an important step towards greater nuclear security by combating, preventing, and ultimately punishing those who would engage in nuclear theft, sabotage or even terrorism. It demonstrates that there is indeed a global commitment to remedy weaknesses in our nuclear security regime.' The amended CPPNM makes it legally binding for States Parties to protect nuclear facilities and material in peaceful domestic use, storage as well as transport. It will also provide for expanded cooperation between and among States regarding rapid measures to locate and recover stolen or smuggled nuclear material, mitigate any radiological consequences of sabotage, and prevent and combat related offences. The original CPPNM applied only to nuclear material in international transport. Conference President Dr. Alec Baer said 'All 89 delegations demonstrated real unity of purpose. They put aside some very genuine national concerns in favour of the global interest and the result is a much improved convention that is better suited to addressing the nuclear security challenges we currently face.' The new rules will come into effect once they have been ratified by two-thirds of the 112 States Parties of the Convention, expected to take several years. 'But concrete actions are already taking place around the world. For more than 3 years, the IAEA has been implementing a systematic Nuclear Security plan, including physical protection activities designed to prevent, detect and respond to malicious acts,' said Anita Nillson, Director of the IAEA's Office of Nuclear Security. The Agency's Nuclear Security Fund, set up after the events of 9/11, has delivered $19.5 million in practical assistance to 121 countries

  7. (When) Do Stronger Patents Increase Continual Innovation?

    OpenAIRE

    Chen, Yongmin; Pan, Shiyuan; Zhang, Tianle

    2012-01-01

    Under continual innovation, greater patent strength expands innovating firms’ profit against imitation, but also shifts profit from current to past innovators. We show how the impact of patents on innovation, as determined by these two opposing effects, varies with industry characteristics. When the discount factor is sufficiently high, the negative profit division effect is negligible, and innovation monotonically increases in patent strength; otherwise, innovation has an inverted-U relation...

  8. Collective Impact: Stronger Results with Community-Based Organizations

    Science.gov (United States)

    ExpandED Schools, 2014

    2014-01-01

    Cross-sector cradle-to-career initiatives are increasingly central to communities' strategies to support children and youth. StriveTogether Cradle to Career Civic Infrastructure provides a framework for how a community comes together around a vision; improves and builds upon those efforts over time; and invests the community's resources…

  9. Stronger Schrödinger-like uncertainty relations

    International Nuclear Information System (INIS)

    Song, Qiu-Cheng; Qiao, Cong-Feng

    2016-01-01

    Highlights: • A stronger Schrödinger-like uncertainty relation in the sum of variances of two observables is obtained. • An improved Schrödinger-like uncertainty relation in the product of variances of two observables is obtained. • A stronger uncertainty relation in the sum of variances of three observables is proposed. - Abstract: Uncertainty relation is one of the fundamental building blocks of quantum theory. Nevertheless, the traditional uncertainty relations do not fully capture the concept of incompatible observables. Here we present a stronger Schrödinger-like uncertainty relation, which is stronger than the relation recently derived by Maccone and Pati (2014) [11]. Furthermore, we give an additive uncertainty relation which holds for three incompatible observables, which is stronger than the relation newly obtained by Kechrimparis and Weigert (2014) [12] and the simple extension of the Schrödinger uncertainty relation.

  10. Simulation of the Beam-Beam Effects in e+e- Storage Rings with a Method of Reducing the Region of Mesh

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai

    2000-08-31

    A highly accurate self-consistent particle code to simulate the beam-beam collision in e{sup +}e{sup -} storage rings has been developed. It adopts a method of solving the Poisson equation with an open boundary. The method consists of two steps: assigning the potential on a finite boundary using the Green's function, and then solving the potential inside the boundary with a fast Poisson solver. Since the solution of the Poisson's equation is unique, the authors solution is exactly the same as the one obtained by simply using the Green's function. The method allows us to select much smaller region of mesh and therefore increase the resolution of the solver. The better resolution makes more accurate the calculation of the dynamics in the core of the beams. The luminosity simulated with this method agrees quantitatively with the measurement for the PEP-II B-factory ring in the linear and nonlinear beam current regimes, demonstrating its predictive capability in detail.

  11. MD 2197: Experimental studies of Landau damping by means of Beam Transfer Function measurements in the presence of beam-beam interactions and diffusive mechanisms

    CERN Document Server

    Tambasco, Claudia; Barranco Garcia, Javier; Boccardi, Andrea; Buffat, Xavier; Bruce, Roderik; Gasior, Marek; Hostettler, Michi; Lefevre, Thibaut; Louro Alves, Diogo Miguel; Metral, Elias; Persson, Tobias Hakan Bjorn; Pieloni, Tatiana; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; CERN. Geneva. ATS Department

    2018-01-01

    Beam Transfer Function (BTF) measurements are direct measurement of the stability diagrams that define the stability threshold of coherent beam instabilities driven by the impedance. At the LHC, some coherent instabilities at flat top energy are still not fully understood and the BTF measurements provide a method to experimentally probe the Landau damping of the proton beams. The BTF response is sensitive to the particle distribution changes and contain information about the transverse tune spread in the beams. The BTF system has been installed in the LHC in the 2015 in order to investigate the Landau damping at different stages of the operational cycle, machine configurations (different octupole currents, crossing angles, tunes etc...) and in presence of beam-beam excited resonances that may provoke diffusion mechanisms with a consequence change of Landau damping. Past MDs showed some difficulties for the reconstruction of the stability diagram from BTF measurements and several improvements on the BTF sy...

  12. Women's political participation leads to stronger local economies ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Edgard Rodriguez - IDRC. Women attend a self-help group meeting near Hyderabad, India. Keenara Khanderia. Under changes to India's constitution, Indian women are gaining a stronger political voice. Legal reforms are encouraging women to contribute to economic growth and investments in community growth.

  13. A Stronger Reason for the Right to Sign Languages

    Science.gov (United States)

    Trovato, Sara

    2013-01-01

    Is the right to sign language only the right to a minority language? Holding a capability (not a disability) approach, and building on the psycholinguistic literature on sign language acquisition, I make the point that this right is of a stronger nature, since only sign languages can guarantee that each deaf child will properly develop the…

  14. The right of the stronger: The play Sisyphus and critias

    Directory of Open Access Journals (Sweden)

    Jordović Ivan

    2004-01-01

    Full Text Available The Focus of this study is the standpoint of the play Sisyphus and critias the leader of the thirty towards the right of the stronger. this is a question of constant interest in scientific circles, since its answer can serve as the indicator of the influence this famous theory has had. this interest has been encouraged by the fact that critias’ authorship of the play is questionable. however, the question of the author is not of primary importance for this article, because there are some arguments, among some well known ones, which were not considered and which Show that in this satire, regardless of the author and the purpose of this fragment, the right of the stronger is actually non-existant. the first argument to support this theory is that nomosphysis antithesis is nowhere explicitly mentioned although it is the crucial element of the right of the stronger. in addition there is no claim in the play that the exploitation of the strong by the week or by law accrued. the second argument is that despite the incapability of laws to prevent the secret injustice, they and their importance for the human society are depicted in a positive light. it should also be noted that, unlike callicles and glaucon, laws are created to stop the bad and not the good. the third argument is that the invention of religion is accepted as a positive achievement, which finally enables the overcoming of primeval times and lawlessness. the reflection of this argument is a positive characterization of the individual who invented the fear of gods. the fourth argument, which has not been taken into consideration so far is the way the supporters and opponents of lawlessness are described and marked as κακοί and έσξλοί in the satire only physically strong are considered as strong as opposed to callicles, where they are also spiritually superior. intelectually superior in Sisyphus is the inventor of the fear of gods who is also in favor of law and order. the fact

  15. Stronger misdirection in curved than in straight motion

    Directory of Open Access Journals (Sweden)

    Jorge eOtero-Millan

    2011-11-01

    Full Text Available Illusions developed by magicians are a rich and largely untapped source of insight into perception and cognition. Here we show that curved motion, as employed by the magician in a classic sleight of hand trick, generates stronger misdirection than rectilinear motion, and that this difference can be explained by the differential engagement of the smooth pursuit and the saccadic oculomotor systems. This research moreover exemplifies how the magician’s intuitive understanding of the spectator’s mindset can surpass that of the cognitive scientist in specific instances, and that observation-based behavioral insights developed by magicians are worthy of quantitative investigation in the neuroscience laboratory.

  16. Global compensation of long-range beam-beam effects with octupole magnets: dynamic aperture simulations for the HL-LHC case and possible usage in LHC and FCC.

    CERN Document Server

    Barranco Garcia, Javier; CERN. Geneva. ATS Department

    2017-01-01

    The Large Hadron Collider has shown with various experimental verifications that one of the main limitations to the collider performance and to a possible upgrade can come from the long-range beam-beam effects which will define the operational parameters (intensities and emittances) and machine set-up (crossing angles and the minimum beta function at the interaction points). The High Luminosity project aims at very high intensities and will therefore need much larger separations to keep the long range effects weak. In the past several studies of possible active compensators have been carried out and experimental studies are planned to explore such schemes in the LHC. In this note we show the feasibility of using octupole magnets to compensate the effects of long range beam-beam interactions by use of dynamical aperture simulations. A prove of principle of such a compensation scheme is shown for the HL-LHC optics. Preliminary studies for the LHC optics ATS and standard are also presented pointing to the import...

  17. Conservatives Anticipate and Experience Stronger Emotional Reactions to Negative Outcomes.

    Science.gov (United States)

    Joel, Samantha; Burton, Caitlin M; Plaks, Jason E

    2014-02-01

    The present work examined whether conservatives and liberals differ in their anticipation of their own emotional reactions to negative events. In two studies, participants imagined experiencing positive or negative outcomes in domains that do not directly concern politics. In Study 1, 190 American participants recruited online (64 male, Mage  = 32 years) anticipated their emotional responses to romantic relationship outcomes. In Study 2, 97 Canadian undergraduate students (26 male, Mage  = 21 years) reported on their anticipated and experienced emotional responses to academic outcomes. In both studies, more conservative participants predicted they would feel stronger negative emotions following negative outcomes than did more liberal participants. Furthermore, a longitudinal follow-up of Study 2 participants revealed that more conservative participants actually felt worse than more liberal participants after receiving a lower-than-desired exam grade. These effects remained even when controlling for the Big Five traits, prevention focus, and attachment style (Study 1), and optimism (Study 2). We discuss how the relationship between political orientation and anticipated affect likely contributes to differences between conservatives and liberals in styles of decision and policy choices. © 2013 Wiley Periodicals, Inc.

  18. Stronger inducible defences enhance persistence of intraguild prey.

    Science.gov (United States)

    Kratina, Pavel; Hammill, Edd; Anholt, Bradley R

    2010-09-01

    1. Intraguild predation is widespread in nature despite its potentially destabilizing effect on food web dynamics. 2. Anti-predator inducible defences affect both birth and death rates of populations and have the potential to substantially modify food web dynamics and possibly increase persistence of intraguild prey. 3. In a chemostat experiment, we investigated the long-term effects of inducible defences on the dynamics of aquatic microbial food webs consisting of an intraguild predator, intraguild prey, and a basal resource. We controlled environmental conditions and selected strains of intraguild prey that varied in the strength of expressed inducible defences. 4. We found that intraguild prey with a stronger tendency to induce an anti-predator morphology persist for significantly longer periods of time. In addition, model selection analysis implied that flexibility in defensive phenotype (inducibility itself) is most likely the factor responsible for the enhanced persistence. 5. As patterns at the community level often emerge as a result of the life-history traits of individuals, we propose that inducible defences increase the persistence of populations and may contribute to the widespread occurrence of theoretically unstable intraguild predation systems in nature.

  19. Is Polar Amplification Deeper and Stronger than Dynamicists Assume?

    Science.gov (United States)

    Scheff, J.; Maroon, E.

    2017-12-01

    In the CMIP multi-model mean under strong future warming, Arctic amplification is confined to the lower troposphere, so that the meridional gradient of warming reverses around 500 mb and the upper troposphere is characterized by strong "tropical amplification" in which warming weakens with increasing latitude. This model-derived pattern of warming maxima in the upper-level tropics and lower-level Arctic has become a canonical assumption driving theories of the large-scale circulation response to climate change. Yet, several lines of evidence and reasoning suggest that Arctic amplification may in fact extend through the entire depth of the troposphere, and/or may be stronger than commonly modeled. These include satellite Microwave Sounding Unit (MSU) temperature trends as a function of latitude and vertical level, the recent discovery that the extratropical negative cloud phase feedback in models is largely spurious, and the very strong polar amplification observed in past warm and lukewarm climates. Such a warming pattern, with deep, dominant Arctic amplification, would have very different implications for the circulation than a canonical CMIP-like warming: instead of slightly shifting poleward and strengthening, eddies, jets and cells might shift equatorward and considerably weaken. Indeed, surface winds have been mysteriously weakening ("stilling") at almost all stations over the last half-century or so, there has been no poleward shift in northern hemisphere circulation metrics, and past warm climates' subtropics were apparently quite wet (and their global ocean circulations were weak.) To explore these possibilities more deeply, we examine the y-z structure of warming and circulation changes across a much broader range of models, scenarios and time periods than the CMIP future mean, and use an MSU simulator to compare them to the satellite warming record. Specifically, we examine whether the use of historical (rather than future) forcing, AMIP (rather than CMIP

  20. Increasing Arctic sea ice export driven by stronger winds

    Science.gov (United States)

    Sorteberg, A.; Smedsrud, L. H.; Sirevaag, A.; Kloster, K.

    2010-12-01

    Arctic sea ice area has decreased steadily over the last three decades. A thinner and more seasonal Arctic ice cover, related to increased long wave radiation, has become evident. Changes in circulation, including drift patterns of the Arctic pack ice, have been less obvious. Arctic sea ice export estimates have been hampered by low resolution spatial and temporal satellite imagery, especially during summer, making accurate detection difficult. Here we present a new ice area export dataset calculated from sea ice motion and concentration profiles along 79N. Ice drift vectors are calculated from ice feature displacement using Envisat ASAR WideSwath images every 3 days from 2004 while ice concentration is based on DMSP F13 SSMI and AQUA AMSR-E brightness temperature data. The two data sets are combined to give the ice-area flux in consecutive 3-day periods, uninterrupted year-round coverage along 79N. It is shown that sea ice export variability is closely linked to the geostrophic wind in the Fram Strait (correlation of 0.84). Using geostrophic winds from reanalysis back to the 1950s as a proxy for ice export indicates that the Arctic sea ice has annually lost an increasing area since the 1950's driven by stronger winds. Ice concentration has decreased slightly, but does not contribute significantly. The ice export has overall increased by ~25% over the period. Using cyclone tracking the changes in winds seems directly related to a higher low pressure activity in the Nordic Seas. Our results demonstrate that the changes in atmospheric circulation over the Arctic and sub-Arctic have contributed to a trend in the Fram Strait ice export. The Fram Strait between Greenland and Svalbard with average sea ice concentration for summer (red, June through August) and winter (black, January through March). Solid lines are 50%, dashed lines are 15%. Above mean southward ice drift across 79N from August 2004 to July 2010 in 1 degree bins based on SAR imagery, and mean ice

  1. Does Good Corporate Governance Lead to Stronger Productivity Growth?

    NARCIS (Netherlands)

    Koeke, J.; Renneboog, L.D.R.

    2002-01-01

    This study investigates the impact of corporate governance and product market competition on total factor productivity growth in Germany and the UK.For Germany, the prototype of a bank-based governance system, productivity grows faster in firms controlled by financial institutions (in particular,

  2. One Year After Fukushima, Nuclear Safety Is Stronger

    International Nuclear Information System (INIS)

    2012-01-01

    Full text: Nuclear power is safer than it was a year ago as the nuclear industry, regulators and governments act on the lessons of Fukushima, but that safety must never be taken for granted, said Yukiya Amano, Director General of the International Atomic Energy Agency (IAEA). Speaking ahead of the first anniversary of the Fukushima Daiichi nuclear accident on 11 March, Amano said a culture of constant vigilance and improvement was vital to ensure that the benefits of nuclear power could be harnessed as safely as humanly possible. 'Nuclear safety is stronger than it was a year ago', he said. 'Fukushima Daiichi was a very serious accident, but we know what went wrong and we have a clear course of action to tackle those causes - not only in Japan, but anywhere in the world. 'Now we have to keep up the momentum. Complacency can kill'. On 11 March 2011 a huge earthquake and tsunami left more than 20 000 people dead or missing in eastern Japan. Amidst widespread destruction, the tsunami slammed into the Fukushima Daiichi Nuclear Power Station, disabling cooling systems and leading to fuel meltdowns in three of the six Units. The accident was a jolt to the nuclear industry, regulators and governments. It was triggered by a massive force of nature, but it was existing weaknesses of design regarding defence against natural hazards, regulatory oversight, accident management and emergency response that allowed it to unfold as it did. For example: The nuclear regulator was not sufficiently independent, allowing weak oversight of the operator, TEPCO, and regulatory requirements fell short of international best practice; Not enough attention was paid to guarding against possible extreme events at the Fukushima Daiichi site, leaving critical safety functions such as cooling systems vulnerable to the tsunami; Training to respond to serious accidents was inadequate, as were mitigation measures to prevent hydrogen explosions and protect the venting system; and Accident command lines

  3. The El Niño Southern Oscillation is Getting Bigger and Stronger

    Science.gov (United States)

    McNaught, C.; O'Brien, J.; Strazzo, S. E.

    2012-12-01

    The El Niño Southern Oscillation (ENSO) is an important natural climate variation that affects large portions of the world. We measure ENSO both in terms of its frequency and its magnitude. The different phases of ENSO - El Niño and La Niña - have different properties, and impact the global weather pattern differently. We examine the hypothesis that ENSO's frequency distribution is changing. We demonstrate that, indeed, El Niño's are getting stronger as measured by the maximum anomaly in sea surface temperature (SST). An analysis of the ENSO principal component is conducted using a fast Fourier transform to estimate the spectrum of the SST of the time series. We conclude that the intensity of El Niño events during the period 1970-2010 is statistically significantly higher when compared to the 1930—1970, with a broad spectral peak centered around 4 years. When we compare the SST spectrum for the period 1930-1970 with the spectrum for 1971- 2010, we find the latter period to be much stronger in power. Additionally recently classified ENSO types, including El Niño Modoki and Warm Pool ENSO, are briefly studied.; The first empirical orthogonal function of sea-surface temperatures (1930-2010) accounting for 75% of the variance. The values are indicative of departures from the mean, in °C. Positive (negative) values indicate anomalously higher (lower) sea-surface temperatures ; Normalized first principal component

  4. Stronger declines in youth alcohol consumption thanks to stronger integrated alcohol policies? A qualitative comparison of ten Dutch municipalities

    NARCIS (Netherlands)

    de Goeij, Moniek C. M.; Harting, Janneke; Kunst, Anton E.

    2017-01-01

    Little detailed evidence is available on how integrated policies could impact population health and under what conditions such policies could be realized. The aim of this study was to assess how youth alcohol consumption trends in the province of Noord-Brabant, The Netherlands, were related to the

  5. The imperative for stronger vaccine supply and logistics systems.

    Science.gov (United States)

    Zaffran, Michel; Vandelaer, Jos; Kristensen, Debra; Melgaard, Bjørn; Yadav, Prashant; Antwi-Agyei, K O; Lasher, Heidi

    2013-04-18

    With the introduction of new vaccines, developing countries are facing serious challenges in their vaccine supply and logistics systems. Storage capacity bottlenecks occur at national, regional, and district levels and system inefficiencies threaten vaccine access, availability, and quality. As countries adopt newer and more expensive vaccines and attempt to reach people at different ages and in new settings, their logistics systems must be strengthened and optimized. As a first step, national governments, donors, and international agencies have crafted a global vision for 2020 vaccine supply and logistics systems with detailed plans of action to achieve five priority objectives. Vaccine products and packaging are designed to meet the needs of developing countries. Immunization supply systems support efficient and effective vaccine delivery. The environmental impact of energy, materials, and processes used in immunization systems is minimized. Immunization information systems enable better and more timely decision-making. Competent and motivated personnel are empowered to handle immunization supply chain issues. Over the next decade, vaccine supply and logistics systems in nearly all developing countries will require significant investments of time and resources from global and national partners, donors, and governments. These investments are critical if we are to reach more people with current and newer vaccines. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Ministers at IAEA Conference Call for Stronger Nuclear Security

    International Nuclear Information System (INIS)

    2013-01-01

    Declaration says. The Declaration recognizes the threat to international security posed by theft and smuggling of nuclear material and affirms the responsibility of States to keep all nuclear material secure. It also encourages all States to join and participate in the IAEA Incident and Trafficking Database, the international repository of information about nuclear and other radioactive material that has fallen out of regulatory control. It invites States that have not yet done so to become party to, and fully implement, the Convention on the Physical Protection of Nuclear Material (CPPNM) and its 2005 Amendment, which broadens the scope of that Convention. Many ministers at the Conference stated that entry into force of the Amendment would make a big difference. Among a number of other issues that are addressed, the Declaration also encourages States to use, on a voluntary basis, the IAEA's nuclear security advisory services and peer reviews such as International Physical Protection Advisory Service (IPPAS) missions, which are based on internationally accepted guidance and tailored to national needs. The Ministers welcomed the IAEA's work in nuclear forensics, and recognized its efforts to raise awareness of the growing threat of cyber-attacks and their potential impact on nuclear security. The work of the Conference will contribute to the IAEA's Nuclear Security Plan for 2014 to 2017. Consultations on the Declaration among IAEA Member States were coordinated by Ambassador Balazs Csuday, Resident Representative of Hungary, and Ambassador Laercio Antonio Vinhas, Resident Representative of Brazil. (IAEA)

  7. Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning.

    Science.gov (United States)

    Leach, Prescott T; Kenney, Justin W; Gould, Thomas J

    2015-02-01

    Increased training often results in stronger memories but the neural changes responsible for these stronger memories are poorly understood. It is proposed here that higher levels of training that result in stronger memories recruit additional cell signaling cascades. This study specifically examined if c-Jun N-terminal kinase 1 (JNK1) is involved in the formation of stronger fear conditioning memories. Wildtype (WT), JNK1 heterozygous (Het), and JNK1 knockout (KO) mice were fear conditioned with 1 trial, 2 trials, or 4 trials. All mice learned both contextual (hippocampus-dependent) and cued (hippocampus-independent) fear conditioning but for contextual fear conditioning only, the JNK1 KO mice did not show higher levels of learning with increased trials. That is, WT mice showed a significant linear increase in contextual fear conditioning as training trials increased from 1 to 2 to 4 trials whereas KO mice showed the same level of contextual fear conditioning as WT mice for 1 trial training but did not have increased levels of contextual fear conditioning with additional trials. These data suggest that JNK1 may not be critical for learning but when higher levels of hippocampus-dependent learning occur, JNK1 signaling is recruited and is necessary for stronger hippocampus-dependent memory formation. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Harmful drinking after job loss: a stronger association during the post-2008 economic crisis?

    Science.gov (United States)

    de Goeij, Moniek C M; Bruggink, Jan-Willem; Otten, Ferdy; Kunst, Anton E

    2017-06-01

    This study investigated, among the Dutch working population, whether job loss during the post-2008 economic crisis is associated with harmful drinking and whether this association is stronger than before the crisis. Repeated cross-sectional data from the Dutch Health Interview Survey 2004-2013 were used to define episodic drinking (≥6 glasses on 1 day ≥1/week) and chronic drinking (≥14 glasses/week for women and ≥21 for men). These data were linked to longitudinal data from tax registries, to measure the experience and duration of job loss during a 5-year working history. Before the crisis, job loss experience and duration were not associated with harmful drinking. During the crisis, job loss for more than 6 months was associated with episodic drinking [OR 1.40 (95% CI 1.01; 1.94)], while current job loss was associated with chronic drinking [OR 1.43 (95% CI 1.03; 1.98)]. These associations were most clear in men and different between the pre-crisis and crisis period (p interaction = 0.023 and 0.035, respectively). The results suggest that economic crises strengthen the potential impact of job loss on harmful drinking, predominately among men.

  9. Beam-beam effects and generalized luminosity

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, J.E.

    1996-01-01

    The assumption is made that before an NLC is approved, a prototype will be necessary that demonstrates the feasibility of a general purpose linear collider capable of {rvec e}{sup {+-}}{rvec e}{sup {+-}}, {rvec {gamma}}{rvec e} and {rvec {gamma}}{rvec {gamma}} incident channels. At an upgraded SLC, such channels could provide new physics over a range of energies upwards of a few GeV. Effects that limit the luminosity of a GLC are discussed together with their possible mitigations. The expected luminosities in the different channels are then predicted in a consistent way for {radical}s{sub ee} = 0.5 TeV.

  10. Predatory blue crabs induce stronger nonconsumptive effects in eastern oysters Crassostrea virginica than scavenging blue crabs

    Directory of Open Access Journals (Sweden)

    Avery E. Scherer

    2017-02-01

    Full Text Available By influencing critical prey traits such as foraging or habitat selection, predators can affect entire ecosystems, but the nature of cues that trigger prey reactions to predators are not well understood. Predators may scavenge to supplement their energetic needs and scavenging frequency may vary among individuals within a species due to preferences and prey availability. Yet prey reactions to consumers that are primarily scavengers versus those that are active foragers have not been investigated, even though variation in prey reactions to scavengers or predators might influence cascading nonconsumptive effects in food webs. Oysters Crassostrea virginica react to crab predators by growing stronger shells. We exposed oysters to exudates from crabs fed live oysters or fed aged oyster tissue to simulate scavenging, and to controls without crab cues. Oysters grew stronger shells when exposed to either crab exudate, but their shells were significantly stronger when crabs were fed live oysters. The stronger response to predators than scavengers could be due to inherent differences in diet cues representative of reduced risk in the presence of scavengers or to degradation of conspecific alarm cues in aged treatments, which may mask risk from potential predators subsisting by scavenging.

  11. Stronger Accent Following a Stroke: The Case of a Trilingual with Aphasia

    Science.gov (United States)

    Levy, Erika S.; Goral, Mira; De Diesbach, Catharine Castelluccio; Law, Franzo, II

    2011-01-01

    This study documents patterns of change in speech production in a multilingual with aphasia following a cerebrovascular accident (CVA). EC, a right-handed Hebrew-English-French trilingual man, had a left fronto-temporo-parietal CVA, after which he reported that his (native) Hebrew accent became stronger in his (second language) English. Recordings…

  12. Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity

    DEFF Research Database (Denmark)

    Harndahl, Mikkel Nors; Rasmussen, Michael; Nielsen, Morten

    2012-01-01

    Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity Mikkel Harndahla, Michael Rasmussena, Morten Nielsenb, Soren Buusa,∗ a Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark b Center for Biological Seq...... al., 2007. J. Immunol. 178, 7890–7901. doi:10.1016/j.molimm.2012.02.025...

  13. First-order dominance: stronger characterization and a bivariate checking algorithm

    DEFF Research Database (Denmark)

    Range, Troels Martin; Østerdal, Lars Peter Raahave

    2018-01-01

    distributions. Utilizing that this problem can be formulated as a transportation problem with a special structure, we provide a stronger characterization of multivariate first-order dominance and develop a linear time complexity checking algorithm for the bivariate case. We illustrate the use of the checking...

  14. Fasting insulin is a stronger cardiovascular risk factor in women than in men

    NARCIS (Netherlands)

    Oterdoom, Leendert H.; de Vries, Aiko P. J.; Gansevoort, Ron T.; de Jong, Paul E.; Gans, Reinold O. B.; Bakker, Stephan J. L.

    Diabetes is a stronger risk factor for cardiovascular disease (CVD) in women than in men. It is not known whether there is also a sex difference in the association between hyperinsulinaemia, reflecting insulin resistance, and CVD. Fasting insulin was assessed with a specific assay in 6916 fasting,

  15. A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

    DEFF Research Database (Denmark)

    Heydorn, S; Andersen, Klaus Ejner; Johansen, Jeanne Duus

    2003-01-01

    Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch test...

  16. A Human Capital Framework for a Stronger Teacher Workforce. Advancing Teaching--Improving Learning. White Paper

    Science.gov (United States)

    Myung, Jeannie; Martinez, Krissia; Nordstrum, Lee

    2013-01-01

    Building a stronger teacher workforce requires the thoughtful orchestration of multiple processes working together in a human capital system. This white paper presents a framework that can be used to take stock of current efforts to enhance the teacher workforce in school districts or educational organizations, as well as their underlying theories…

  17. Harmful drinking after job loss: a stronger association during the post-2008 economic crisis?

    NARCIS (Netherlands)

    de Goeij, Moniek C. M.; Bruggink, Jan-Willem; Otten, Ferdy; Kunst, Anton E.

    2017-01-01

    This study investigated, among the Dutch working population, whether job loss during the post-2008 economic crisis is associated with harmful drinking and whether this association is stronger than before the crisis. Repeated cross-sectional data from the Dutch Health Interview Survey 2004-2013 were

  18. Can absolute and proportional anthropometric characteristics distinguish stronger and weaker powerlifters?

    Science.gov (United States)

    Keogh, Justin W L; Hume, Patria A; Pearson, Simon N; Mellow, Peter J

    2009-11-01

    This study sought to compare the anthropometric profiles of 17 weaker and 17 stronger Australasian and Pacific powerlifters who had competed in a regional-, national-, or international-level powerlifting competition in New Zealand. Stronger lifters were defined as those having a Wilks score greater than 410, whereas those in the weaker group had a Wilks score less than 370. Each powerlifter was assessed for 37 anthropometric dimensions by International Society for the Advancement of Kinanthropometry (ISAK) level II and III accredited anthropometrists. Because all powerlifters were highly mesomorphic and possessed large girths and bone breadths, both in absolute terms and when expressed as Phantom-Z scores compared through the Phantom, relatively few significant anthropometric differences were observed. However, stronger lifters had significantly greater muscle mass and larger muscular girths in absolute terms as well as greater Brugsch Index (chest girth/height) and "Phantom"-normalized muscle mass, upper arm, chest, and forearm girths. In terms of the segment lengths and bone breadths, the only significant difference was that stronger lifters had a significantly shorter lower leg than weaker lifters. Because the majority of the significant differences were for muscle mass and muscular girths, it would appear likely that these differences contributed to the stronger lifters' superior performance. Powerlifters may therefore need to devote some of their training to the development of greater levels of muscular hypertrophy if they wish to continue to improve their performance. To better understand the anthropometric determinants of muscular strength, future research should recruit larger samples (particularly of elite lifters) and follow these subjects prospectively.

  19. Crosstalk in concurrent repeated games impedes direct reciprocity and requires stronger levels of forgiveness.

    Science.gov (United States)

    Reiter, Johannes G; Hilbe, Christian; Rand, David G; Chatterjee, Krishnendu; Nowak, Martin A

    2018-02-07

    Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays simultaneously have no effect on each other. Here we introduce a general framework that allows us to analyze "crosstalk" between a player's concurrent games. In the presence of crosstalk, the action a person experiences in one game can alter the person's decision in another. We find that crosstalk impedes the maintenance of cooperation and requires stronger levels of forgiveness. The magnitude of the effect depends on the population structure. In more densely connected social groups, crosstalk has a stronger effect. A harsh retaliator, such as Tit-for-Tat, is unable to counteract crosstalk. The crosstalk framework provides a unified interpretation of direct and upstream reciprocity in the context of repeated games.

  20. A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

    DEFF Research Database (Denmark)

    Heydorn, S; Andersen, K E; Johansen, J D

    2003-01-01

    elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests......Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch test...... (+, ++ or +++) on the forearm patch tested with 6 concentrations of SLS plus hydroxycitronellal than on the forearm tested with 6 concentrations of hydroxycitronellal alone and no day of patch test readings showing more positive tests on the hydroxycitronellal forearm. 15/20 (75%) had at least 1 day of patch test reading...

  1. Daytime warming has stronger negative effects on soil nematodes than night-time warming

    OpenAIRE

    Yan, Xiumin; Wang, Kehong; Song, Lihong; Wang, Xuefeng; Wu, Donghui

    2017-01-01

    Warming of the climate system is unequivocal, that is, stronger warming during night-time than during daytime. Here we focus on how soil nematodes respond to the current asymmetric warming. A field infrared heating experiment was performed in the western of the Songnen Plain, Northeast China. Three warming modes, i.e. daytime warming, night-time warming and diurnal warming, were taken to perform the asymmetric warming condition. Our results showed that the daytime and diurnal warming treatmen...

  2. World Bank: Management Controls Stronger, But Challenges in Fighting Corruption Remain

    Science.gov (United States)

    2000-04-01

    outline for possible World Development Report on institutions, including corruption . Completed • Prepare Europe and Central Asia Region...Management Controls Stronger, but Challenges in Fighting Corruption Remain If , 20000417 062 G A O Accountability * Integrity * Reliability GAO... corruption —broadly defined as the abuse of public office for private gain— ’The "World Bank" and "Bank" refer to the World Bank Group of institutions

  3. A stronger version of matrix convexity as applied to functions of Hermitian matrices

    Directory of Open Access Journals (Sweden)

    Kagan Abram

    1999-01-01

    Full Text Available A stronger version of matrix convexity, called hyperconvexity is introduced. It is shown that the function is hyperconvex on the set of Hermitian matrices and is hyperconvex on the set of positive definite Hermitian matrices. The new concept makes it possible to consider weighted averages of matrices of different orders. Proofs use properties of the Fisher information matrix, a fundamental concept of mathematical statistics.

  4. Sexual harassment and emotional and behavioural symptoms in adolescence: stronger associations among boys than girls.

    Science.gov (United States)

    Kaltiala-Heino, Riittakerttu; Fröjd, Sari; Marttunen, Mauri

    2016-08-01

    To study the associations between subjection to sexual harassment and emotional (depression) and behavioural (delinquency) symptoms among 14-to-18-year-old adolescents, and gender differences within these associations. 90,953 boys and 91,746 girls aged 14-18 participated in the School Health Promotion Study (SHPS), a school-based survey designed to examine the health, health behaviours, and school experiences of teenagers. Experiences of sexual harassment were elicited with five questions addressing five separate forms of harassment. Depression was measured by the 13-item Beck Depression Inventory and delinquency with a modified version of the International Self-Report Delinquency Study (ISRD) instrument. Data were analysed using cross-tabulations with Chi-square statistics and logistic regression. All sexual harassment experiences studied were associated with both depression (adjusted odds ratios varied from 2.2 to 2.7 in girls and from 2.0 to 5.1 in boys) and delinquency (adjusted odds ratios 3.1-5.0 in girls and 1.7-6.9 in boys). Sexual name-calling had a stronger association with depression and with delinquency in girls (adjusted odds ratios, respectively, 2.4 and 4.2), than in boys (adjusted odds ratios, respectively, 2.0 and 1.7), but otherwise stronger associations with emotional and behavioural symptoms were seen in boys. Subjection to sexual harassment is associated with both emotional and behavioural symptoms in both girls and boys. The associations are mostly stronger for boys. Boys subjected to sexual harassment may feel particularly threatened regarding their masculinity, and there may be less support available for boys traumatised due to sexual harassment.

  5. Building Stronger State Energy Partnerships with the U.S. Department of Energy

    Energy Technology Data Exchange (ETDEWEB)

    David Terry

    2008-09-30

    This final technical report details the results of total work efforts and progress made from July 2000 - July 2008 under the National Association of State Energy Officials (NASEO) cooperative agreement DE-FC26-00NT40802, Building Stronger State Energy Partnerships with the U.S. Department of Energy. Major topical project areas in this final report include work efforts in the following areas: Rebuild America/Energy Smart Schools, Higher Education Initiative, Winter/Summer Fuels Outlook Conferences, Energy Emergency, Clean Energy Integration, Energy Star, and Office of Electricity Delivery and Energy Reliability. All required deliverables have been provided to the National Energy Technology Laboratory and DOE program officials.

  6. The University of Florida Department of Surgery: building a stronger tomorrow on yesterday's foundation.

    Science.gov (United States)

    Behrns, Kevin E; Copeland, Edward M; Howard, Richard J

    2012-01-01

    Established in 1957, the University of Florida Department of Surgery has a solid foundation on which current faculty are driven to build a stronger tomorrow. The department is focused on promoting patient-centered care, expanding its research portfolio to improve techniques and outcomes, and training the surgical leaders of tomorrow. It fosters an environment where faculty, residents, students, and staff challenge long-held traditions with the goal of improving the health of our patients, the quality of our care, and the vitality of our work environment.

  7. Production of plastified wood with stronger static bending strength means of polymerization induced by gamma radiation

    International Nuclear Information System (INIS)

    Silva Filho, Elias

    1999-01-01

    The use of gamma radiation to obtain wood-polymer composites is one of the applications of radiation that presents the most commercial interest. The process, denominated radiopolymerization, comprises the impregnation of monomers into the completely dried wood followed by exposure to gamma radiation to induce polymerization of the impregnated monomers. I this context, the present work aimed the application of this process to seven kinds of wood existing in the brazilian forests. The considered monomer is styrene and the gamma source is Cobalt-60. The obtained wood-polystyrene composites were found to have stronger static bending strength. (author)

  8. Building Stronger State Energy Partnerships with the U.S. Department of Energy

    Energy Technology Data Exchange (ETDEWEB)

    Marks, Kate

    2011-09-30

    This final technical report details the results of total work efforts and progress made from October 2007 – September 2011 under the National Association of State Energy Officials (NASEO) cooperative agreement DE-FC26-07NT43264, Building Stronger State Energy Partnerships with the U.S. Department of Energy. Major topical project areas in this final report include work efforts in the following areas: Energy Assurance and Critical Infrastructure, State and Regional Technical Assistance, Regional Initiative, Regional Coordination and Technical Assistance, and International Activities in China. All required deliverables have been provided to the National Energy Technology Laboratory and DOE program officials.

  9. Do External or Internal Technology Spillovers Have a Stronger Influence on Innovation Efficiency in China?

    Directory of Open Access Journals (Sweden)

    Xionghe Qin

    2017-09-01

    Full Text Available In this study, we bridge an important gap in the literature by comparing the extent to which external technology spillovers, as indicated by foreign direct investment (FDI, and internal technology spillovers, as indicated by university-institute-industry cooperation (UIC, influence innovation efficiency in China. We divide the innovation process into two sequential stages, namely the knowledge creation and technology commercialization stages, and employ a network data envelopment analysis approach to measure innovation efficiency at each stage. The spatial analysis of the distribution of knowledge creation efficiency and technology commercialization efficiency reveals the heterogeneity of innovation efficiency at the provincial level. Then, a panel data regression is used to analyze the effect of FDI and UIC on innovation efficiency at each stage, using data from 2009 to 2015 for 30 provinces in China. By comparing FDI with UIC, we find that FDI has a higher coefficient and stronger significance level at the knowledge creation stage, while only industry-institute linkages exhibit a stronger association with innovation efficiency at the technology commercialization stage.

  10. Stronger interference from distractors in the right hemifield during visual search.

    Science.gov (United States)

    Carlei, Christophe; Kerzel, Dirk

    2018-03-01

    The orientation-bias hypothesis states that there is a bias to attend to the right visual hemifield (RVF) when there is spatial competition between stimuli in the left and right hemifield [Pollmann, S. (1996). A pop-out induced extinction-like phenomenon in neurologically intact subjects. Neuropsychologia, 34(5), 413-425. doi: 10.1016/0028-3932(95)00125-5 ]. In support of this hypothesis, stronger interference was reported for RVF distractors with contralateral targets. In contrast, previous studies using rapid serial visual presentation (RSVP) found stronger interference from distractors in the left visual hemifield (LVF). We used the additional singleton paradigm to test whether this discrepancy was due to the different distractor features that were employed (colour vs. orientation). Interference from the colour distractor with contralateral targets was larger in the RVF than in the LVF. However, the asymmetrical interference disappeared when observers had to search for an inconspicuous colour target instead of the inconspicuous shape target. We suggest that the LVF orienting-bias is limited to situations where search is driven by bottom-up saliency (singleton search) instead of top-down search goals (feature search). In contrast, analysis of the literature suggests the opposite for the LVF bias in RSVP tasks. Thus, the attentional asymmetry may depend on whether the task involves temporal or spatial competition, and whether search is based on bottom-up or top-down signals.

  11. When surging seas meet stronger rain: Nuclear techniques in flood management

    International Nuclear Information System (INIS)

    Quevenco, Rodolfo

    2015-01-01

    Unusually high rainfall in many parts of the world is a result of climate change, scientists say. Since warmer air can hold more water, the rationale goes, increased temperatures will increase the chances of stronger rainfall events. And when surging seas combine with stronger rain, the outcome is almost certain: floods. Floods are the most frequently occurring natural disasters, and south-east Asia is particularly vulnerable. Climate change and variability are expected to bring about increased typhoon activities, rising sea levels and off-season monsoon rains in southeast Asia and other regions. These can cause devastating floods in countries like Cambodia, Laos, Pakistan, the Philippines, Thailand and Viet Nam. For the residents of these countries who have survived the ravages of major floods, the road to recovery can be long and arduous. As the flood water recedes, they have to contend with new forms of flood: floods of concern and worries as to how to rebuild their houses, their lives and their cities. Governments, too, face huge challenges in rebuilding roads, public buildings, infrastructure and natural resources destroyed or polluted by the flood.

  12. Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity

    DEFF Research Database (Denmark)

    Harndahl, Mikkel Nors; Rasmussen, Michael; Nielsen, Morten

    2012-01-01

    of antigen processing and presentation in defining cytotoxic T lymphocyte (CTL) immunogenicity Assarsson et al., 2007. Using an affinity-balanced approach, we demonstrated that immunogenic peptides tend to be more stably bound to MHC-I molecules compared with non-immunogenic peptides. We also developed......Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity Mikkel Harndahla, Michael Rasmussena, Morten Nielsenb, Soren Buusa,∗ a Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark b Center for Biological...... Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Denmark Efficient presentation of peptide-MHC class I (pMHC-I) complexes to immune T cells should benefit from a stable peptide- MHC-I interaction. However, it has been difficult to distinguish stability from other...

  13. Bone mineral content has stronger association with lean mass than fat mass among Indian urban adolescents

    Directory of Open Access Journals (Sweden)

    Raman K Marwaha

    2015-01-01

    Full Text Available Introduction: There are conflicting reports on the relationship of lean mass (LM and fat mass (FM with bone mineral content (BMC. Given the high prevalence of Vitamin D deficiency in India, we planned the study to evaluate the relationship between LM and FM with BMC in Indian children and adolescents. The objective of the study was to evaluate the relationship of BMC with LM and FM. Materials and Methods: Total and regional BMC, LM, and FM using dual energy X-ray absorptiometry and pubertal staging were assessed in 1403 children and adolescents (boys [B]: 826; girls [G]: 577. BMC index, BMC/LM and BMC/FM ratio, were calculated. Results: The age ranged from 5 to 18 years, with a mean age of 13.2 ± 2.7 years. BMC adjusted for height (BMC index and BMC/height ratio was comparable in both genders. There was no difference in total BMC between genders in the prepubertal group but were higher in more advanced stages of pubertal maturation. The correlation of total as well as regional BMC was stronger for LM (B: Total BMC - 0.880, trunk - 0.715, leg - 0.894, arm - 0.891; G: Total BMC - 0.827, leg - 0.846, arm - 0.815 (all value indicate r2 , P < 0.0001 for all when compared with FM (B: Total BMC - 0.776, trunk - 0.676, leg - 0.772, arm - 0.728; G: Total BMC - 0.781, leg - 0.741, arm - 0.689; all P < 0.0001 except at trunk BMC (LM - 0.682 vs. FM - 0.721; all P < 0.0001, even after controlling for age, height, pubertal stage, and biochemical parameters. Conclusions: BMC had a stronger positive correlation with LM than FM.

  14. Increased fire frequency promotes stronger spatial genetic structure and natural selection at regional and local scales in Pinus halepensis Mill.

    Science.gov (United States)

    Budde, Katharina B; González-Martínez, Santiago C; Navascués, Miguel; Burgarella, Concetta; Mosca, Elena; Lorenzo, Zaida; Zabal-Aguirre, Mario; Vendramin, Giovanni G; Verdú, Miguel; Pausas, Juli G; Heuertz, Myriam

    2017-04-01

    The recurrence of wildfires is predicted to increase due to global climate change, resulting in severe impacts on biodiversity and ecosystem functioning. Recurrent fires can drive plant adaptation and reduce genetic diversity; however, the underlying population genetic processes have not been studied in detail. In this study, the neutral and adaptive evolutionary effects of contrasting fire regimes were examined in the keystone tree species Pinus halepensis Mill. (Aleppo pine), a fire-adapted conifer. The genetic diversity, demographic history and spatial genetic structure were assessed at local (within-population) and regional scales for populations exposed to different crown fire frequencies. Eight natural P. halepensis stands were sampled in the east of the Iberian Peninsula, five of them in a region exposed to frequent crown fires (HiFi) and three of them in an adjacent region with a low frequency of crown fires (LoFi). Samples were genotyped at nine neutral simple sequence repeats (SSRs) and at 251 single nucleotide polymorphisms (SNPs) from coding regions, some of them potentially important for fire adaptation. Fire regime had no effects on genetic diversity or demographic history. Three high-differentiation outlier SNPs were identified between HiFi and LoFi stands, suggesting fire-related selection at the regional scale. At the local scale, fine-scale spatial genetic structure (SGS) was overall weak as expected for a wind-pollinated and wind-dispersed tree species. HiFi stands displayed a stronger SGS than LoFi stands at SNPs, which probably reflected the simultaneous post-fire recruitment of co-dispersed related seeds. SNPs with exceptionally strong SGS, a proxy for microenvironmental selection, were only reliably identified under the HiFi regime. An increasing fire frequency as predicted due to global change can promote increased SGS with stronger family structures and alter natural selection in P. halepensis and in plants with similar life history traits

  15. Density regulation in Northeast Atlantic fish populations: Density dependence is stronger in recruitment than in somatic growth.

    Science.gov (United States)

    Zimmermann, Fabian; Ricard, Daniel; Heino, Mikko

    2018-01-30

    Population regulation is a central concept in ecology, yet in many cases its presence and the underlying mechanisms are difficult to demonstrate. The current paradigm maintains that marine fish populations are predominantly regulated by density-dependent recruitment. While it is known that density-dependent somatic growth can be present too, its general importance remains unknown and most practical applications neglect it. This study aimed to close this gap by for the first time quantifying and comparing density dependence in growth and recruitment over a large set of fish populations. We fitted density-dependent models to time-series data on population size, recruitment and age-specific weight from commercially exploited fish populations in the Northeast Atlantic Ocean and the Baltic Sea. Data were standardized to enable a direct comparison within and among populations, and estimated parameters were used to quantify the impact of density regulation on population biomass. Statistically significant density dependence in recruitment was detected in a large proportion of populations (70%), whereas for density dependence in somatic growth the prevalence of density dependence depended heavily on the method (26% and 69%). Despite age-dependent variability, the density dependence in recruitment was consistently stronger among age groups and between alternative approaches that use weight-at-age or weight increments to assess growth. Estimates of density-dependent reduction in biomass underlined these results: 97% of populations with statistically significant parameters for growth and recruitment showed a larger impact of density-dependent recruitment on population biomass. The results reaffirm the importance of density-dependent recruitment in marine fishes, yet they also show that density dependence in somatic growth is not uncommon. Furthermore, the results are important from an applied perspective because density dependence in somatic growth affects productivity and

  16. Regular Exercisers Have Stronger Pelvic Floor Muscles than Non-Regular Exercisers at Midpregnancy.

    Science.gov (United States)

    Bø, Kari; Ellstrøm Engh, Marie; Hilde, Gunvor

    2017-12-26

    Today, all healthy pregnant women are encouraged to be physically active throughout pregnancy, with recommendations to participate in at least 30 min of aerobic activity on most days of the week, in addition to perform strength training of the major muscle groups 2-3 days per week, and also pelvic floor muscle training. There is, however, an ongoing debate whether general physical activity enhances or declines pelvic floor muscle function. To compare vaginal resting pressure, pelvic floor muscle strength and endurance in regular exercisers (exercise ≥ 30 minutes ≥ 3 times per week) and non-exercisers at mid-pregnancy. Furthermore, to assess whether regular general exercise or pelvic floor muscle strength was associated with urinary incontinence. This was a cross-sectional study at mean gestational week 20.9 (± 1.4) including 218 nulliparous pregnant women, mean age 28.6 years (range 19-40) and pre-pregnancy body mass index 23.9 kg/m 2 (SD 4.0). Vaginal resting pressure, pelvic floor muscle strength and pelvic floor muscle endurance were measured by a high precision pressure transducer connected to a vaginal balloon. International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form was used to assess urinary incontinence. Differences between groups were analyzed using Independent Sample T-test. Linear regression analysis was conducted to adjust for pre-pregnancy body mass index, age, smoking during pregnancy and regular pelvic floor muscle training during pregnancy. P-value was set to ≤ 0.05. Regular exercisers had statistically significant stronger ( mean 6.4 cm H 2 O (95% CI: 1.7, 11.2)) and more enduring ( mean 39.9 cm H 2 Osec (95% CI: 42.2, 75.7)) pelvic floor muscles. Only pelvic floor muscle strength remained statistically significant, when adjusting for possible confounders. Pelvic floor muscle strength and not regular general exercise was associated with urinary continence (adjusted B: -6.4 (95% CI: -11.5, -1.4)). Regular

  17. Hippocampal-Prefrontal Reactivation during Learning Is Stronger in Awake Compared with Sleep States.

    Science.gov (United States)

    Tang, Wenbo; Shin, Justin D; Frank, Loren M; Jadhav, Shantanu P

    2017-12-06

    Hippocampal sharp-wave ripple (SWR) events occur during both behavior (awake SWRs) and slow-wave sleep (sleep SWRs). Awake and sleep SWRs both contribute to spatial learning and memory, thought to be mediated by the coordinated reactivation of behavioral experiences in hippocampal-cortical circuits seen during SWRs. Current hypotheses suggest that reactivation contributes to memory consolidation processes, but whether awake and sleep reactivation are suited to play similar or different roles remains unclear. Here we addressed that issue by examining the structure of hippocampal (area CA1) and prefrontal (PFC) activity recorded across behavior and sleep stages in male rats learning a spatial alternation task. We found a striking state difference: prefrontal modulation during awake and sleep SWRs was surprisingly distinct, with differing patterns of excitation and inhibition. CA1-PFC synchronization was stronger during awake SWRs, and spatial reactivation, measured using both pairwise and ensemble measures, was more structured for awake SWRs compared with post-task sleep SWRs. Stronger awake reactivation was observed despite the absence of coordination between network oscillations, namely hippocampal SWRs and cortical delta and spindle oscillations, which is prevalent during sleep. Finally, awake CA1-PFC reactivation was enhanced most prominently during initial learning in a novel environment, suggesting a key role in early learning. Our results demonstrate significant differences in awake and sleep reactivation in the hippocampal-prefrontal network. These findings suggest that awake SWRs support accurate memory storage and memory-guided behavior, whereas sleep SWR reactivation is better suited to support integration of memories across experiences during consolidation. SIGNIFICANCE STATEMENT Hippocampal sharp-wave ripples (SWRs) occur both in the awake state during behavior and in the sleep state after behavior. Awake and sleep SWRs are associated with memory

  18. Stronger associations of obesity with prehypertension and hypertension in young women than in young men.

    Science.gov (United States)

    Wakabayashi, Ichiro

    2012-07-01

    Obesity is an important risk factor for prehypertension and hypertension, and there are sex-specific differences in prevalences of obesity and hypertension. The aim of this study was to determine whether sex influences the relationships of obesity with prehypertension and hypertension. The participants were 28,325 Japanese men and women aged 20-39 years. Obesity was evaluated by BMI (≥ 25 kg/m) and waist-to-height ratio (WHtR ≥ 0.5). Associations of obesity with prehypertension and hypertension were compared in men and women by using odds ratio (OR) and area under the curve (AUC). ORs for prehypertension and hypertension in participants with vs. participants without high BMI or WHtR were significantly higher than a reference level of 1.00 both in men and women and were significantly higher in women than in men. ORs for prehypertension and hypertension of participants with vs. participants without high BMI were 3.10 (2.84-3.38) (men) vs. 5.54 (4.80-6.40) (women) (P men) vs. 34.58 (26.55-45.04) (women) (P men. The results suggest that the associations of obesity with prehypertension and hypertension are stronger in women than in men.

  19. Stronger activation of SREBP-1a by nucleus-localized HBx

    International Nuclear Information System (INIS)

    Wu, Qi; Qiao, Ling; Yang, Jian; Zhou, Yan; Liu, Qiang

    2015-01-01

    We previously showed that hepatitis B virus (HBV) X protein activates the sterol regulatory element-binding protein-1a (SREBP-1a). Here we examined the role of nuclear localization of HBx in this process. In comparison to the wild-type and cytoplasmic HBx, nuclear HBx had stronger effects on SREBP-1a and fatty acid synthase transcription activation, intracellular lipid accumulation and cell proliferation. Furthermore, nuclear HBx could activate HBV enhancer I/X promoter and was more effective on up-regulating HBV mRNA level in the context of HBV replication than the wild-type HBx, while the cytoplasmic HBx had no effect. Our results demonstrate the functional significance of the nucleus-localized HBx in regulating host lipogenic pathway and HBV replication. - Highlights: • Nuclear HBx is more effective on activating SREBP-1a and FASN transcription. • Nuclear HBx is more effective on enhancing intracellular lipid accumulation. • Nuclear HBx is more effective on enhancing cell proliferation. • Nuclear HBx up-regulates HBV enhancer I/X promoter activity. • Nuclear HBx increases HBV mRNA level in the context of HBV replication

  20. Stronger activation of SREBP-1a by nucleus-localized HBx

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Qi [VIDO-InterVac, Veterinary Microbiology, University of Saskatchewan, Saskatoon (Canada); Qiao, Ling [VIDO-InterVac, University of Saskatchewan, Saskatoon, Saskatchewan (Canada); Yang, Jian [Drug Discovery Group, University of Saskatchewan, Saskatoon, Saskatchewan (Canada); Zhou, Yan [VIDO-InterVac, Veterinary Microbiology, Vaccinology and Immunotherapeutics, University of Saskatchewan, Saskatoon, Saskatchewan (Canada); Liu, Qiang, E-mail: qiang.liu@usask.ca [VIDO-InterVac, Veterinary Microbiology, Vaccinology and Immunotherapeutics, University of Saskatchewan, Saskatoon, Saskatchewan (Canada)

    2015-05-08

    We previously showed that hepatitis B virus (HBV) X protein activates the sterol regulatory element-binding protein-1a (SREBP-1a). Here we examined the role of nuclear localization of HBx in this process. In comparison to the wild-type and cytoplasmic HBx, nuclear HBx had stronger effects on SREBP-1a and fatty acid synthase transcription activation, intracellular lipid accumulation and cell proliferation. Furthermore, nuclear HBx could activate HBV enhancer I/X promoter and was more effective on up-regulating HBV mRNA level in the context of HBV replication than the wild-type HBx, while the cytoplasmic HBx had no effect. Our results demonstrate the functional significance of the nucleus-localized HBx in regulating host lipogenic pathway and HBV replication. - Highlights: • Nuclear HBx is more effective on activating SREBP-1a and FASN transcription. • Nuclear HBx is more effective on enhancing intracellular lipid accumulation. • Nuclear HBx is more effective on enhancing cell proliferation. • Nuclear HBx up-regulates HBV enhancer I/X promoter activity. • Nuclear HBx increases HBV mRNA level in the context of HBV replication.

  1. Length effects in pseudo-word spelling: stronger in dyslexic than in non-dyslexic students.

    Science.gov (United States)

    Juul, Holger; Petersen, Dorthe Klint

    2017-10-01

    It is often discussed whether dyslexics show a deviant pattern of reading and spelling development when compared to typically developing students, or whether they follow the same pattern as other students, only at markedly slower rate. The present cross-sectional study investigated phonological encoding skills in dyslexic Danish students. We compared dyslexic and non-dyslexic students from grades 3, 5, 7, and 9 and examined whether effects of item length were stronger in the dyslexic groups. Mixed between-within subjects analyses of variance revealed significant interactions between dyslexia status and item length as the dyslexics at all grade levels were more affected by item length than their non-dyslexic peers. A marked developmental delay was apparent as the dyslexic group from grade 9 performed on approximately the same level as the non-dyslexic group from grade 3. Although the overall difference between these two groups was not significant, a significant interaction between dyslexia status and item length remained because the grade 9 dyslexics were more affected by item length than the younger non-dyslexic students. This difference in error profiles suggests a difference in the developmental patterns of dyslexic vs. non-dyslexic students.

  2. Brain Potentials Highlight Stronger Implicit Food Memory for Taste than Health and Context Associations.

    Science.gov (United States)

    Hoogeveen, Heleen R; Jolij, Jacob; Ter Horst, Gert J; Lorist, Monicque M

    2016-01-01

    Increasingly consumption of healthy foods is advised to improve population health. Reasons people give for choosing one food over another suggest that non-sensory features like health aspects are appreciated as of lower importance than taste. However, many food choices are made in the absence of the actual perception of a food's sensory properties, and therefore highly rely on previous experiences of similar consumptions stored in memory. In this study we assessed the differential strength of food associations implicitly stored in memory, using an associative priming paradigm. Participants (N = 30) were exposed to a forced-choice picture-categorization task, in which the food or non-food target images were primed with either non-sensory or sensory related words. We observed a smaller N400 amplitude at the parietal electrodes when categorizing food as compared to non-food images. While this effect was enhanced by the presentation of a food-related word prime during food trials, the primes had no effect in the non-food trials. More specifically, we found that sensory associations are stronger implicitly represented in memory as compared to non-sensory associations. Thus, this study highlights the neuronal mechanisms underlying previous observations that sensory associations are important features of food memory, and therefore a primary motive in food choice.

  3. Phytoplankton Communities Exhibit a Stronger Response to Environmental Changes than Bacterioplankton in Three Subtropical Reservoirs.

    Science.gov (United States)

    Liu, Lemian; Yang, Jun; Lv, Hong; Yu, Xiaoqing; Wilkinson, David M; Yang, Jun

    2015-09-15

    The simultaneous analysis of multiple components of ecosystems is crucial for comprehensive studies of environmental changes in aquatic ecosystems, but such studies are rare. In this study, we analyzed simultaneously the bacterioplankton and phytoplankton communities in three Chinese subtropical reservoirs and compared the response of these two components to seasonal environmental changes. Time-lag analysis indicated that the temporal community dynamics of both bacterioplankton and phytoplankton showed significant directional changes, and variance partitioning suggested that the major reason was the gradual improvement of reservoir water quality from middle eutrophic to oligo-mesotrophic levels during the course of our study. In addition, we found a higher level of temporal stability or stochasticity in the bacterioplankton community than in the phytoplankton community. Potential explanations are that traits associated with bacteria, such as high abundance, widespread dispersal, potential for rapid growth rates, and rapid evolutionary adaptation, may underlie the different stability or stochasticity of bacterioplankton and phytoplankton communities to the environmental changes. In addition, the indirect response of bacterioplankton to nitrogen and phosphorus may result in the fact that environmental deterministic selection was stronger for the phytoplankton than for the bacterioplankton communities.

  4. Age differences in autobiographical memory across the adult lifespan: older adults report stronger phenomenology.

    Science.gov (United States)

    Luchetti, Martina; Sutin, Angelina R

    2018-01-01

    As an individual's life story evolves across adulthood, the subjective experience (phenomenology) of autobiographical memory likely changes. In addition to age at retrieval, both the recency of the memory and the age when a memory is formed may be particularly important to its phenomenology. The present work examines the effect of three temporal factors on phenomenology ratings: (a) age of the participant, (b) age at the event reported in the memory, and (c) memory age (recency). A large sample of Americans (N = 1120), stratified by chronological age, recalled and rated two meaningful memories, a Turning Point and an Early Childhood Memory. Ratings of phenomenology (e.g., vividness of turning points) were higher among older adults compared to younger adults. Memories of events from the reminiscence bump were more positive in valence than events from other time periods but did not differ on other phenomenological dimensions; recent memories had stronger phenomenology than remote memories. In contrast to phenomenology, narrative content was generally unrelated to participant age, age at the event, or memory age. Overall, the findings indicate age-related differences in how meaningful memories are re-experienced.

  5. Speed versus endurance tradeoff in plants: Leaves with higher photosynthetic rates show stronger seasonal declines.

    Science.gov (United States)

    Zhang, Yong-Jiang; Sack, Lawren; Cao, Kun-Fang; Wei, Xue-Mei; Li, Nan

    2017-02-10

    We tested for a tradeoff across species between plant maximum photosynthetic rate and the ability to maintain photosynthesis under adverse conditions in the unfavorable season. Such a trade-off would be consistent with the observed trade-off between maximum speed and endurance in athletes and some animals that has been explained by cost-benefit theory. This trend would have importance for the general understanding of leaf design, and would simplify models of annual leaf carbon relations. We tested for such a trade-off using a database analysis across vascular plants and using an experimental approach for 29 cycad species, representing an ancient plant lineage with diversified evergreen leaves. In both tests, a higher photosynthetic rate per mass or per area in the favorable season was associated with a stronger absolute or percent decline in the unfavorable season. We resolved a possible mechanism based on biomechanics and nitrogen allocation; cycads with high leaf toughness (leaf mass per area) and higher investment in leaf construction than in physiological function (C/N ratio) tended to have lower warm season photosynthesis but less depression in the cool season. We propose that this trade-off, consistent with cost-benefit theory, represents a significant physio-phenological constraint on the diversity and seasonal dynamics of photosynthetic rate.

  6. A stronger necessary condition for the multistationarity of chemical reaction networks.

    Science.gov (United States)

    Soliman, Sylvain

    2013-11-01

    Biochemical reaction networks grow bigger and bigger, fed by the high-throughput data provided by biologists and bred in open repositories of models allowing merging and evolution. Nevertheless, since the available data is still very far from permitting the identification of the increasing number of kinetic parameters of such models, the necessity of structural analyses for describing the dynamics of chemical networks appears stronger every day. Using the structural information, notably from the stoichiometric matrix, of a biochemical reaction system, we state a more strict version of the famous Thomas' necessary condition for multistationarity. In particular, the obvious cases where Thomas' condition was trivially satisfied, mutual inhibition due to a multimolecular reaction and mutual activation due to a reversible reaction, can now easily be ruled out. This more strict condition shall not be seen as some version of Thomas' circuit functionality for the continuous case but rather as related and complementary to the whole domain of the structural analysis of (bio)chemical reaction systems, as pioneered by the chemical reaction network theory.

  7. Plant Identity Exerts Stronger Effect than Fertilization on Soil Arbuscular Mycorrhizal Fungi in a Sown Pasture.

    Science.gov (United States)

    Zheng, Yong; Chen, Liang; Luo, Cai-Yun; Zhang, Zhen-Hua; Wang, Shi-Ping; Guo, Liang-Dong

    2016-10-01

    Arbuscular mycorrhizal (AM) fungi play key roles in plant nutrition and plant productivity. AM fungal responses to either plant identity or fertilization have been investigated. However, the interactive effects of different plant species and fertilizer types on these symbiotic fungi remain poorly understood. We evaluated the effects of the factorial combinations of plant identity (grasses Avena sativa and Elymus nutans and legume Vicia sativa) and fertilization (urea and sheep manure) on AM fungi following 2-year monocultures in a sown pasture field study. AM fungal extraradical hyphal density was significantly higher in E. nutans than that in A. sativa and V. sativa in the unfertilized control and was significantly increased by urea and manure in A. sativa and by manure only in E. nutans, but not by either fertilizers in V. sativa. AM fungal spore density was not significantly affected by plant identity or fertilization. Forty-eight operational taxonomic units (OTUs) of AM fungi were obtained through 454 pyrosequencing of 18S rDNA. The OTU richness and Shannon diversity index of AM fungi were significantly higher in E. nutans than those in V. sativa and/or A. sativa, but not significantly affected by any fertilizer in all of the three plant species. AM fungal community composition was significantly structured directly by plant identity only and indirectly by both urea addition and plant identity through soil total nitrogen content. Our findings highlight that plant identity has stronger influence than fertilization on belowground AM fungal community in this converted pastureland from an alpine meadow.

  8. Geographical constraints are stronger than invasion patterns for European urban floras

    Czech Academy of Sciences Publication Activity Database

    Ricotta, C.; Celesti-Grapow, L.; Kühn, I.; Rapson, G.; Pyšek, Petr; La Sorte, F. A.; Thompson, K.

    2014-01-01

    Roč. 9, č. 1 (2014), s. 1-6, e85661 E-ISSN 1932-6203 Institutional support: RVO:67985939 Keywords : urban floras * plant invasions * Europe Subject RIV: EF - Botanics Impact factor: 3.234, year: 2014

  9. Perceived stress and biological risk: is the link stronger in Russians than in Taiwanese and Americans?

    Science.gov (United States)

    Glei, Dana A; Goldman, Noreen; Shkolnikov, Vladimir M; Jdanov, Dmitri; Shkolnikova, Maria; Vaupel, James W; Weinstein, Maxine

    2013-07-01

    Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n = 1800; age, mean 68.6 years), Taiwan (n = 1036; 65.6 years) and the United States (US; n = 1054; 58.0 years) -- which are likely to vary widely with respect to levels of stress exposure and biological markers -- to determine the magnitude of the association between perceived stress and physiological dysregulation. The measure of overall dysregulation was based on 15 markers including standard cardiovascular/metabolic risk factors as well as markers of inflammation and neuroendocrine activity. Subjective psychological stress was measured by the perceived stress scale. Only the Moscow sample demonstrated a positive association with overall dysregulation in both sexes. In the US, we found an association among women but not men. Among the Taiwanese, who report the lowest perceived stress, there was no association in women but an unexpected inverse relationship in men. The effects also varied across system-level subscores: the association with perceived stress was most consistent for standard cardiovascular/metabolic factors. Perceived stress was associated with inflammation and neuroendocrine activity in some samples. Although the evidence that perceived stress is the primary source of physiological dysregulation is generally modest, it was stronger in Russia where the level of perceived stress was particularly high. For Russia only, we had information about heart function based on a 24 h ambulatory electrocardiogram; perceived stress was consistently associated with heart rate dysregulation in Russian men and women.

  10. Stronger tests of mechanisms underlying geographic gradients of biodiversity: insights from the dimensionality of biodiversity.

    Directory of Open Access Journals (Sweden)

    Richard D Stevens

    Full Text Available Inference involving diversity gradients typically is gathered by mechanistic tests involving single dimensions of biodiversity such as species richness. Nonetheless, because traits such as geographic range size, trophic status or phenotypic characteristics are tied to a particular species, mechanistic effects driving broad diversity patterns should manifest across numerous dimensions of biodiversity. We develop an approach of stronger inference based on numerous dimensions of biodiversity and apply it to evaluate one such putative mechanism: the mid-domain effect (MDE. Species composition of 10,000-km(2 grid cells was determined by overlaying geographic range maps of 133 noctilionoid bat taxa. We determined empirical diversity gradients in the Neotropics by calculating species richness and three indices each of phylogenetic, functional and phenetic diversity for each grid cell. We also created 1,000 simulated gradients of each examined metric of biodiversity based on a MDE model to estimate patterns expected if species distributions were randomly placed within the Neotropics. For each simulation run, we regressed the observed gradient onto the MDE-expected gradient. If a MDE drives empirical gradients, then coefficients of determination from such an analysis should be high, the intercept no different from zero and the slope no different than unity. Species richness gradients predicted by the MDE fit empirical patterns. The MDE produced strong spatially structured gradients of taxonomic, phylogenetic, functional and phenetic diversity. Nonetheless, expected values generated from the MDE for most dimensions of biodiversity exhibited poor fit to most empirical patterns. The MDE cannot account for most empirical patterns of biodiversity. Fuller understanding of latitudinal gradients will come from simultaneous examination of relative effects of random, environmental and historical mechanisms to better understand distribution and abundance of the

  11. BUILDING STRONGER STATE ENERGY PARTNERSHIPS WITH THE U.S. DEPARTMENT OF ENERGY

    Energy Technology Data Exchange (ETDEWEB)

    Kate Burke

    2003-09-01

    This technical progress report includes an update of the progress during the third year of cooperative agreement DE-FC26-00NT40802, Building Stronger State Energy Partnerships with the U.S. Department of Energy. The report also describes the barriers in conduct of the effort, and our assessment of future progress and activities. The approach of the project included three tasks during year three. First, NASEO and its Buildings Committee were to focus on raising awareness and coordination of Rebuild activities. Through education, one-on-one communications, and presentations at NASEO meetings and other events, staff and the committee will assist Rebuild officials in stimulating interest in the program and building greater support among State Energy Office Directors. The most recent subtasks added to the project, though not directly related to Rebuild America, fall under this initial task, and support: (a) state plans to implement integrated energy and environmental initiatives, including distributed generation technologies, and (b) initiation of a state collaborative on advanced turbines and hybrid systems. The advanced turbine piece was completed during this year. During the year, a new workplan was accepted by Rebuild America's Dan Sze to supplement the work in this task. This workplan is outlined below. Second, NASEO would work to improve the efficiency of America's schools by assisting states and DOE in promoting projects that result in more energy efficient and clean energy schools and a better learning environment. This task was fully completed during this year. The third task involves energy security issues which NASEO addressed by way of a Summer Fuels Outlook Conference held Tuesday, April 8, 2003. The purpose of this educational event was to inform state, federal, local, and other energy officials about the most recent transportation fuels data and trends. The public benefits part of this task was not funded for Year 3, thus no activity occurred.

  12. Association Between Self-Esteem and Depressive Symptoms Is Stronger Among Black than White Older Adults.

    Science.gov (United States)

    Assari, Shervin

    2017-08-01

    Although poor self-esteem is a core component of depression, we still do not know if racial and ethnic groups differ in the magnitude of this link. This study compared Black and White older adults on the association between self-esteem and depressive symptoms. With a cross-sectional design, this study enrolled 1493 older individuals (age 66 or more) from the 2001 Religion, Aging, and Health Survey, a nationally representative study in the United States. Participants were either Blacks (n = 734) or Whites (n = 759). Depressive symptoms and self-esteem were measured using brief measures of the Center for Epidemiological Studies-Depression scale (CES-D) and the Rosenberg Self-Esteem Scale, respectively. Demographics, socioeconomics, and self-rated health (SRH) were covariates and self-identified race was the moderator. Linear regression models were used for data analysis. Low self-esteem was associated with more depressive symptoms (B = 0.17, 95 % CI 0.15-0.28), above and beyond all covariates. We found a significant and positive interaction between race (Black) and poor self-esteem on depressive symptoms (B = 0.34, 95 % CI 0.17-0.36), suggesting a stronger association between self-esteem and depressive symptoms among Blacks compared to Whites. Although low self-esteem is associated with higher depressive symptoms in both Whites and Blacks (p self-esteem and high depressive symptoms are more closely associated among Blacks than Whites. It is not clear whether depression leaves a larger scar on self-esteem for Blacks, or Blacks are more vulnerable to the effect of low self-esteem on depression.

  13. The motivation to diet in young women : Fear is stronger than hope

    NARCIS (Netherlands)

    Dalley, Simon E.; Buunk, Abraham P.

    This research examined the relative impact of a hoped-for, thin body and a feared, overweight body on weight-loss dieting (WLD) motivation. We hypothesised that the women most motivated to engage in WLD would report a higher similarity to, and a higher cognitive availability of, a feared, overweight

  14. Alien plants invade more phylogenetically clustered community types and cause even stronger clustering

    Czech Academy of Sciences Publication Activity Database

    Lososová, Z.; de Bello, Francesco; Chytrý, M.; Kühn, I.; Pyšek, Petr; Sádlo, Jiří; Winter, M.; Zelený, D.

    2015-01-01

    Roč. 24, č. 7 (2015), s. 786-794 ISSN 1466-822X R&D Projects: GA ČR GAP505/12/1296; GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : biological invasions * phylogenetic diversity * vegetation type Subject RIV: EH - Ecology, Behaviour Impact factor: 5.840, year: 2015

  15. Stronger evidence for own-age effects in memory for older as compared to younger adults

    Czech Academy of Sciences Publication Activity Database

    Freund, A.M.; Kouřilová, Sylvie; Kuhl, P.

    2011-01-01

    Roč. 19, č. 5 (2011), s. 429-448 ISSN 0965-8211 Institutional research plan: CEZ:AV0Z70250504 Keywords : own- age effect * memory bias * age relevance * age ing Subject RIV: AN - Psychology Impact factor: 2.089, year: 2011

  16. Bell inequalities stronger than the Clauser-Horne-Shimony-Holt inequality for three-level isotropic states

    International Nuclear Information System (INIS)

    Ito, Tsuyoshi; Imai, Hiroshi; Avis, David

    2006-01-01

    We show that some two-party Bell inequalities with two-valued observables are stronger than the CHSH inequality for 3x3 isotropic states in the sense that they are violated by some isotropic states in the 3x3 system that do not violate the CHSH inequality. These Bell inequalities are obtained by applying triangular elimination to the list of known facet inequalities of the cut polytope on nine points. This gives a partial solution to an open problem posed by Collins and Gisin. The results of numerical optimization suggest that they are candidates for being stronger than the I 3322 Bell inequality for 3x3 isotropic states. On the other hand, we found no Bell inequalities stronger than the CHSH inequality for 2x2 isotropic states. In addition, we illustrate an inclusion relation among some Bell inequalities derived by triangular elimination

  17. "This one is stronger". Spotlights on the lifelong learning professional-in-action

    Directory of Open Access Journals (Sweden)

    Josje van der Linden

    2016-06-01

    Full Text Available ABSTRACT“This one is stronger.” Spotlights on the lifelong learning professional-in-action Around the world, lifelong learning is being promoted as a strategy for coping with the changing realities of life and work. The fourth Sustainable Development Goal, agreed in September 2015, reflects this: “ensure equitable and inclusive quality education and promote lifelong learning opportunities for all”. Despite its importance, doubts remain about the implementation of this goal in practice (Van der Kamp, 2000; Regmi, 2015. This article looks at the practice of lifelong learning from the point of view of the professionals involved, their actions and the way these actions are challenged, supported and further developed. Following Schön’s “reflection-in-action” (1983, the term “professional-in-action” is used to stress the role of the professional in making the difference on the ground. The leading question is: how can lifelong learning professionals be supported in their contribution to surrounding society and its citizens? The professionals-in-action featured in this article include professionals based in the Netherlands as well as in other, less privileged contexts. Meaningful experiences are used to build a story about challenges, the right to exist, commitment, recognition and room to manoeuvre. The experiences reveal the importance of interacting with the learner and the professional space that is necessary to achieve this. Professionalization in professional learning communities and practice-oriented research must accompany this professional space. SAMENVATTING“Deze is sterker”. Spotlights op de leven lang leren professional-in-actieOm te kunnen omgaan met de veranderende realiteit in leven en werk, wordt wereldwijd een leven lang leren aangemoedigd. Het vierde duurzame ontwikkelingsdoel, vastgesteld in september 2015, weerspiegelt dit: “het verzekeren van kwalitatief goed onderwijs en het bevorderen van de mogelijkheden

  18. CCR2 elimination in mice results in larger and stronger tibial bones but bone loss is not attenuated following ovariectomy or muscle denervation.

    Science.gov (United States)

    Mader, Tara L; Novotny, Susan A; Lin, Angela S; Guldberg, Robert E; Lowe, Dawn A; Warren, Gordon L

    2014-11-01

    Bone loss due to age and disuse contributes to osteoporosis and increases fracture risk. It has been hypothesized that such bone loss can be attenuated by modulation of the C-C chemokine receptor 2 (CCR2) and/or its ligands. The objectives of this study were to examine the effects of genetic elimination of CCR2 on cortical and trabecular bones in the mouse tibia and how bone loss was impacted following disuse and estrogen loss. Female CCR2 knockout (CCR2(-/-)) and wildtype mice underwent ovariectomy (OVX) or denervation of musculature adjacent to the tibia (DEN) to induce bone loss. Cortical and trabecular structural properties as well as mechanical properties (i.e., strength) of tibial bones were measured. Compared to wildtype mice, CCR2(-/-) mice had tibiae that were up to 9% larger and stronger; these differences could be explained mainly by the 17% greater body mass (P bone loss per se. These findings indicate that while CCR2(-/-) mice do have larger and stronger bones than do wildtype mice, there is minimal evidence that CCR2 elimination provides protection against bone loss during disuse and estrogen loss.

  19. Stronger pack warnings predict quitting more than weaker ones: finding from the ITC Malaysia and Thailand surveys.

    Science.gov (United States)

    Fathelrahman, Ahmed I; Li, Lin; Borland, Ron; Yong, Hua-Hie; Omar, Maizurah; Awang, Rahmat; Sirirassamee, Buppha; Fong, Geoffrey T; Hammond, David

    2013-09-18

    We examined the impact of cigarette pack warning labels on interest in quitting and subsequent quit attempts among adult smokers in Malaysia and Thailand. Two overlapping cohorts of adults who reported smoking factory- made cigarettes from Malaysia and Thailand were interviewed face-to-face (3189 were surveyed at baseline and 1781 re-contacted at Wave 2; 2361 current smokers were surveyed at Wave 2 and 1586 re-contacted at Wave 3). In Thailand at baseline, large text only warnings were assessed, while at Wave 2 new large graphic warnings were assessed. In Malaysia, during both waves small text only warnings were in effect. Reactions were used to predict interest in quitting, and to predict making quit attempts over the following inter-wave interval. Multivariate predictors of "interest in quitting" were comparable across countries, but predictors of quit attempts varied. In both countries, cognitive reactions to warnings (adjusted ORs; 1.57 & 1.69 for Malaysia at wave 1 and wave 2 respectively and 1.29 & 1.19 for Thailand at wave 1 and wave 2 respectively), forgoing a cigarette (except Wave 2 in Malaysia) (adjusted ORs; 1.77 for Malaysia at wave 1 and 1.54 & 2.32 for Thailand at wave 1 and wave 2 respectively), and baseline knowledge (except wave 2 in both countries) (adjusted ORs; 1.71 & 1.51 for Malaysia and Thailand respectively) were positively associated with interest in quitting at that wave. In Thailand only, "cognitive reactions to warnings" (adjusted ORs; 1.12 & 1.23 at wave 1 and wave 2 respectively), "forgoing a cigarette" (adjusted OR = 1.55 at wave 2 only) and "an interest in quitting" (adjusted ORs; 1.61 & 2.85 at wave 1 and wave 2 respectively) were positively associated with quit attempts over the following inter-wave interval. Salience was negatively associated with subsequent quit attempts in both Malaysia and Thailand, but at Wave 2 only (adjusted ORs; 0.89 & 0.88 for Malaysia and Thailand respectively). Warnings appear to have common

  20. Stronger Association Between Valence- and Arousal Ratings of Affective Pictures with Older Age: Evidence for Variation Across Emotion Categories

    DEFF Research Database (Denmark)

    Mikkelsen, Mai Bjørnskov; Mehlsen, Mimi Yung; Lyby, Marlene Skovgaard

    A sample of older and younger adults rated affective pictures according to valence, arousal and emotion category (happiness, sadness and disgust). Results indicate that older age is associated with a stronger linear association between ratings of arousal and valence. Further, the strength...

  1. Pilot testing of the "First You Should Get Stronger" program among caregivers of older adults with dementia.

    Science.gov (United States)

    Lök, Neslihan; Bademli, Kerime

    In this study, randomized controlled interventional study pattern was used to examine the effects of the "First You Should Get Stronger" program on the caregiving burden and healthy life style behavior of caregivers of dementia patients. "Zarit Caregiver Burden Scale" and "Healthy Life Style Behavior Scale" were used. The study was completed with 40 caregivers in total with 20 in the intervention group and 20 in the control group. A statistically significant difference was determined between the "Zarit Caregiving Burden Scale" and "Healthy Life Style Behavior Scale" score averages of the intervention group that participated in the "First You Should Get Stronger" program in comparison with those of the control group. It is important for the healths of caregivers to include similar programs for the caregivers of dementia patients in continuous and regular applications. The results highlight the importance of the "First You Should Get Stronger" program significantly decreased the caregiving burden and significantly developed the healthy lifestyle behaviors of caregivers in the intervention group. Since dementia is a difficult neurological syndrome with patients cared at home, it generally wears out the caregivers significantly. It is suggested that the nurses and healthcare professionals working with dementia patients are evaluated separately and that they carry out caregiving applications within the scope of the "First You Should Get Stronger" program. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Magnetic materials and devices for the 21st century: stronger, lighter, and more energy efficient.

    Science.gov (United States)

    Gutfleisch, Oliver; Willard, Matthew A; Brück, Ekkes; Chen, Christina H; Sankar, S G; Liu, J Ping

    2011-02-15

    A new energy paradigm, consisting of greater reliance on renewable energy sources and increased concern for energy efficiency in the total energy lifecycle, has accelerated research into energy-related technologies. Due to their ubiquity, magnetic materials play an important role in improving the efficiency and performance of devices in electric power generation, conditioning, conversion, transportation, and other energy-use sectors of the economy. This review focuses on the state-of-the-art hard and soft magnets and magnetocaloric materials, with an emphasis on their optimization for energy applications. Specifically, the impact of hard magnets on electric motor and transportation technologies, of soft magnetic materials on electricity generation and conversion technologies, and of magnetocaloric materials for refrigeration technologies, are discussed. The synthesis, characterization, and property evaluation of the materials, with an emphasis on structure-property relationships, are discussed in the context of their respective markets, as well as their potential impact on energy efficiency. Finally, considering future bottlenecks in raw materials, options for the recycling of rare-earth intermetallics for hard magnets will be discussed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Supporting young people living with cancer to tell their stories in ways that make them stronger: The Beads of Life approach.

    Science.gov (United States)

    Portnoy, Sara; Girling, Isabella; Fredman, Glenda

    2016-04-01

    This article describes the 'Beads of Life' approach--a five-part methodology informed by narrative therapy to enable children and young people to make sense of their cancer journey in ways that make them stronger. Young people are invited to use beads as prompts to tell preferred stories of their identity to create a safe place to stand from which to story their cancer journey. The approach positions young people as experts in their lives. It aims to change their relationship with cancer to reduce its negative impact on life by lessening isolation. By enabling medical staff to get to know the young person apart from the cancer, this approach aims to create hope for the future and improve quality of care. © The Author(s) 2015.

  4. Geographical constraints are stronger than invasion patterns for European urban floras.

    Science.gov (United States)

    Ricotta, Carlo; Celesti-Grapow, Laura; Kühn, Ingolf; Rapson, Gillian; Pyšek, Petr; La Sorte, Frank A; Thompson, Ken

    2014-01-01

    Understanding the mechanisms that affect invasion success of alien species is an important prerequisite for the effective management of present and future aliens. To gain insight into this matter we asked the following questions: Are the geographical patterns of species distributions in urban floras different for native compared with alien plant species? Does the introduction of alien species contribute to the homogenization of urban floras? We used a Mantel test on Jaccard dissimilarity matrices of 30 urban floras across the British Isles, Italy and central Europe to compare the spatial distribution of native species with four classes of alien species: archaeophytes, all neophytes, non-invasive neophytes, and invasive neophytes. Archaeophytes and neophytes are species that were introduced into Europe before and after 1500 AD, respectively. To analyze the homogenizing effect of alien species on the native urban floras, we tested for differences in the average dissimilarity of individual cities from their group centroid in ordination space. Our results show that the compositional patterns of native and alien species seem to respond to the same environmental drivers, such that all four classes of alien species were significantly related to native species across urban floras. In this framework, alien species may have an impact on biogeographic patterns of urban floras in ways that reflect their history of introduction and expansion: archaeophytes and invasive neophytes tended to homogenize, while non-invasive neophytes tended to differentiate urban floras.

  5. Global dimming and urbanization: did stronger negative SSR trends collocate with regions of population growth?

    Directory of Open Access Journals (Sweden)

    A. Imamovic

    2016-03-01

    Full Text Available Global dimming refers to the decrease in surface solar radiation (SSR observed from the 1960s to the 1980s at different measurement sites all around the world. It is under debate whether anthropogenic aerosols emitted from urban areas close to the measurement sites are mainly responsible for the dimming. In order to assess this urbanization impact on SSR, we use spatially explicit population density data of 0.08° resolution to construct population indices (PI at 157 high data quality sites. Our study extends previous population-based studies by incorporating distance-weighting as a simple aerosol diffusion model. We measured urbanization in the surrounding of a site as the PI change from 1960 to 1990 and found no negative correlation with the corresponding SSR trends from 1964 to 1989 for the 92 sites in Europe and Japan. For the 39 sites in China the correlation coefficients are significant at the 5 % level and reach around −0.35, while for the 26 remaining Asian, mostly Russian sites the correlation coefficients reach around −0.55 at the 1 % significance level. Results are similar, when the absolute levels of PIs are taken as an indicator for urbanization. Our findings call into question the existence of an urbanization effect for the sites in Europe and Japan, while such an effect cannot be ruled out for the sites in Asia, especially in Russia.

  6. Geographical constraints are stronger than invasion patterns for European urban floras.

    Directory of Open Access Journals (Sweden)

    Carlo Ricotta

    Full Text Available Understanding the mechanisms that affect invasion success of alien species is an important prerequisite for the effective management of present and future aliens. To gain insight into this matter we asked the following questions: Are the geographical patterns of species distributions in urban floras different for native compared with alien plant species? Does the introduction of alien species contribute to the homogenization of urban floras? We used a Mantel test on Jaccard dissimilarity matrices of 30 urban floras across the British Isles, Italy and central Europe to compare the spatial distribution of native species with four classes of alien species: archaeophytes, all neophytes, non-invasive neophytes, and invasive neophytes. Archaeophytes and neophytes are species that were introduced into Europe before and after 1500 AD, respectively. To analyze the homogenizing effect of alien species on the native urban floras, we tested for differences in the average dissimilarity of individual cities from their group centroid in ordination space. Our results show that the compositional patterns of native and alien species seem to respond to the same environmental drivers, such that all four classes of alien species were significantly related to native species across urban floras. In this framework, alien species may have an impact on biogeographic patterns of urban floras in ways that reflect their history of introduction and expansion: archaeophytes and invasive neophytes tended to homogenize, while non-invasive neophytes tended to differentiate urban floras.

  7. Global dimming and urbanization: did stronger negative SSR trends collocate with regions of population growth?

    Science.gov (United States)

    Imamovic, Adel; Tanaka, Katsumasa; Folini, Doris; Wild, Martin

    2016-04-01

    Global dimming refers to the decrease in surface solar radiation (SSR) observed from the 1960s to the 1980s at different measurement sites all around the world. It is under debate whether anthropogenic aerosols emitted from urban areas close to the measurement sites are mainly responsible for the dimming. In order to assess this urbanization impact on SSR, we use spatially explicit population density data of 0.08° resolution to construct population indices (PI) at 157 high data quality sites. Our study extends previous population-based studies by incorporating distance-weighting as a simple aerosol diffusion model. We measured urbanization in the surrounding of a site as the PI change form 1960 to 1990 and found no negative correlation with the corresponding SSR trends from 1964 to 1989 for the 92 sites in Europe and Japan. For the 39 sites in China the correlation coefficients are significant at the 5 % level and reach around -0.35, while for the 26 remaining Asian, mostly Russian sites the correlation coefficients reach around -0.55 at the 1 % significance level. Results are similar, when the absolute levels of PIs are taken as an indicator for urbanization. Our findings call into question the existence of an urbanization effect for the sites in Europe and Japan, while such an effect cannot be ruled out for the sites in Asia, especially in Russia.

  8. Stronger effects of Roundup than its active ingredient glyphosate in damselfly larvae.

    Science.gov (United States)

    Janssens, Lizanne; Stoks, Robby

    2017-12-01

    Pesticides are causing strong decreases in aquatic biodiversity at concentrations assumed safe by legislation. One reason for the failing risk assessment may be strong differences in the toxicity of the active ingredient of pesticides and their commercial formulations. Sublethal effects, especially those on behaviour, have been largely ignored in this context, yet can be equally important as lethal effects at the population and ecosystem levels. Here, we compared the toxicity of the herbicide Roundup and its active ingredient glyphosate on survival, but also on ecologically relevant sublethal traits (life history, behaviour and physiology) in damselfly larvae. Roundup was more toxic than glyphosate with negative effects on survival, behaviour and most of the physiological traits being present at lower concentrations (food intake, escape swimming speed) or even only present (survival, sugar and total energy content and muscle mass) following Roundup exposure. This confirms the toxicity of the surfactant POEA. Notably, also glyphosate was not harmless: a realistic concentration of 2mg/l resulted in reduced growth rate, escape swimming speed and fat content. Our results therefore indicate that the toxicity of Roundup cannot be fully attributed to its surfactant, thereby suggesting that also the new generation of glyphosate-based herbicides with other mixtures of surfactants likely will have adverse effects on non-target aquatic organisms. Ecotoxicological studies comparing the toxicity of active ingredients and their commercial formulations typically ignore behaviour while the here observed differential effects on behaviour likely will negatively impact damselfly populations. Our data highlight that risk assessment of pesticides ignoring sublethal effects may contribute to the negative effects of pesticides on aquatic biodiversity. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Land use not litter quality is a stronger driver of decomposition in hyperdiverse tropical forest.

    Science.gov (United States)

    Both, Sabine; Elias, Dafydd M O; Kritzler, Ully H; Ostle, Nick J; Johnson, David

    2017-11-01

    In hyperdiverse tropical forests, the key drivers of litter decomposition are poorly understood despite its crucial role in facilitating nutrient availability for plants and microbes. Selective logging is a pressing land use with potential for considerable impacts on plant-soil interactions, litter decomposition, and nutrient cycling. Here, in Borneo's tropical rainforests, we test the hypothesis that decomposition is driven by litter quality and that there is a significant "home-field advantage," that is positive interaction between local litter quality and land use. We determined mass loss of leaf litter, collected from selectively logged and old-growth forest, in a fully factorial experimental design, using meshes that either allowed or precluded access by mesofauna. We measured leaf litter chemical composition before and after the experiment. Key soil chemical and biological properties and microclimatic conditions were measured as land-use descriptors. We found that despite substantial differences in litter quality, the main driver of decomposition was land-use type. Whilst inclusion of mesofauna accelerated decomposition, their effect was independent of land use and litter quality. Decomposition of all litters was slower in selectively logged forest than in old-growth forest. However, there was significantly greater loss of nutrients from litter, especially phosphorus, in selectively logged forest. The analyses of several covariates detected minor microclimatic differences between land-use types but no alterations in soil chemical properties or free-living microbial composition. These results demonstrate that selective logging can significantly reduce litter decomposition in tropical rainforest with no evidence of a home-field advantage. We show that loss of key limiting nutrients from litter (P & N) is greater in selectively logged forest. Overall, the findings hint at subtle differences in microclimate overriding litter quality that result in reduced

  10. Long-term perspective underscores need for stronger near-term policies on climate change

    Science.gov (United States)

    Marcott, S. A.; Shakun, J. D.; Clark, P. U.; Mix, A. C.; Pierrehumbert, R.; Goldner, A. P.

    2014-12-01

    Despite scientific consensus that substantial anthropogenic climate change will occur during the 21st century and beyond, the social, economic and political will to address this global challenge remains mired in uncertainty and indecisiveness. One contributor to this situation may be that scientific findings are often couched in technical detail focusing on near-term changes and uncertainties and often lack a relatable long-term context. We argue that viewing near-term changes from a long-term perspective provides a clear demonstration that policy decisions made in the next few decades will affect the Earth's climate, and with it our socio-economic well-being, for the next ten millennia or more. To provide a broader perspective, we present a graphical representation of Earth's long-term climate history that clearly identifies the connection between near-term policy options and the geological scale of future climate change. This long view is based on a combination of recently developed global proxy temperature reconstructions of the last 20,000 years and model projections of surface temperature for the next 10,000 years. Our synthesis places the 20th and 21st centuries, when most emissions are likely to occur, into the context of the last twenty millennia over which time the last Ice Age ended and human civilization developed, and the next ten millennia, over which time the projected impacts will occur. This long-term perspective raises important questions about the most effective adaptation and mitigation policies. For example, although some consider it economically viable to raise seawalls and dikes in response to 21st century sea level change, such a strategy does not account for the need for continuously building much higher defenses in the 22nd century and beyond. Likewise, avoiding tipping points in the climate system in the short term does not necessarily imply that such thresholds will not still be crossed in the more distant future as slower components

  11. Impacts

    NARCIS (Netherlands)

    Hellmuth, M.; Kabat, P.

    2003-01-01

    Even without the impacts of climate change, water managers face prodigious challenges in meeting sustainable development goals. Growing populations need affordable food, water and energy. Industrial development demands a growing share of water resources and contaminates those same resources with its

  12. Review of linear collider beam-beam interaction

    Energy Technology Data Exchange (ETDEWEB)

    Chen, P.

    1989-01-01

    Three major effects from the interaction of e/sup +/e/sup /minus// beams---disruption, beamstrahlung, and electron-positron pair creation---are reviewed. For the disruption effects we discuss the luminosity enhancement factor, the maximum and rms disruption angles, and the ''kink instability''. All the results are obtained from computer simulations. Scaling laws for the numerical results and theoretical explanations of the computer acquired phenomena are offered wherever possible. For the beamstrahlung effects we concentrate only on the final electron energy spectrum resulting from multiple photon radiation process, and the deflection angle associated with low energy particles. For the effects from electron-positron pair creation, both coherent and incoherent processes of beamstrahlung pair creation are discussed. In addition to the estimation on total number of such pairs, we also look into the energy spectrum and the deflection angle. 17 refs., 23 figs., 1 tab.

  13. Limitations Imposed by Beam-Beam Effects and Their Remedies

    International Nuclear Information System (INIS)

    Spencer, James E.

    2000-01-01

    Effects that limit the luminosities of a general purpose linear collider or GLC capable of spin polarized e ± e ± , gamma-e ± and spin polarized gamma-gamma incident channels are discussed together with potential mitigations. The relative characteristics of such channels and their luminosities are predicted based on differing assumptions - including those for the current configurations for the NLC at square root s ee = 0.5 and 1.0 TeV. Disadvantages related to the increased complexity of linear colliders can be offset by broader design constraints that seek to optimize the generalized luminosity. Decreased disruptions and bunch charges are effective and can be used in combination with feasible charge compensation schemes to predict higher luminosities and power conversion efficiencies. The incremental costs of additional channels is modest compared to the cost of any one by itself or potential gains in the integrated luminosity

  14. Decision making of heavy cannabis users on the Iowa Gambling Task: stronger association with THC of hair analysis than with personality traits of the Tridimensional Personality Questionnaire.

    Science.gov (United States)

    Hermann, Derik; Leménager, Tagrid; Gelbke, Jan; Welzel, Helga; Skopp, Gisela; Mann, Karl

    2009-01-01

    It is unclear whether impairment in decision making, measured by the Iowa Gambling Task (IGT), in addiction is substance-induced or the consequence of personality structure. Analysis of the IGT, the Tridimensional Personality Questionnaire (TPQ) and cannabinoids in hair and urine were performed in 13 cannabis users and matched controls. Hair Delta(9)-tetrahydrocannabinol (THC) correlated negatively with the last subtrial (cards 80-100) of the IGT (R = -0.67). In all participants (n = 26) the TPQ dimension, harm avoidance, correlated negatively with the total IGT score (R = -0.46). The last IGT-subtrial correlated with adventure seeking (R = 0.43), harm avoidance (R = -0.39) and reward dependence (R = -0.44). The last subtrial gives information on whether a participant has learned the IGT strategy. Multiple regression confirmed the impact of THC on the last subtrial, whereas TPQ personality traits did not additionally explain variance. Former indications of the IGT performance depending on the amount of cannabis consumed were replicated with an objective measurement of chronic cannabis consumption (hair THC). Multiple regression analysis argues for a stronger impact of chronic THC consumption than personality traits, but does not provide a causal relationship. Other factors (e.g. genetic) may also play a role. 2009 S. Karger AG, Basel.

  15. IMPACTS !

    CERN Document Server

    2008-01-01

    (Photo courtesy of Don Davis / NASA)The University of Geneva (UNIGE) and the Ecole Polytechnique Fédérale of Lausanne (EPFL) are organising the 4th series of public lectures on astronomy, on the theme of "Impacts". The schedule is as follows: Il y a 100 ans : une explosion dans la Tunguska – Dr. Frédéric COURBIN, EPFL Les impacts sur Terre – Prof. Didier Queloz, UNIGE La fin des dinosaures – Dr. Stéphane Paltani, UNIGE Wednesday 7 May 2008, from 7.00 p.m. to 9.00 p.m. Auditoire CO1, EPFL, Ecublens Thursday 08 May 2008, from 7.00 p.m. to 9.00 p.m. Auditoire Rouiller, Uni-Dufour, Genève All 3 lectures will be givent each evening! Admission free Information: 022 379 22 00

  16. Glass Stronger than Steel

    Science.gov (United States)

    Yarris, Lynn

    2011-03-28

    A new type of damage-tolerant metallic glass, demonstrating a strength and toughness beyond that of steel or any other known material, has been developed and tested by a collaboration of researchers from Berkeley Lab and Caltech.

  17. Are Tornadoes Getting Stronger?

    Science.gov (United States)

    Elsner, J.; Jagger, T.

    2013-12-01

    A cumulative logistic model for tornado damage category is developed and examined. Damage path length and width are significantly correlated to the odds of a tornado receiving the next highest damage category. Given values for the cube root of path length and square root of path width, the model predicts a probability for each category. The length and width coefficients are insensitive to the switch to the Enhanced Fujita (EF) scale and to distance from nearest city although these variables are statistically significant in the model. The width coefficient is sensitive to whether or not the tornado caused at least one fatality. This is likely due to the fact that the dimensions and characteristics of the damage path for such events are always based on ground surveys. The model predicted probabilities across the categories are then multiplied by the center wind speed from the categorical EF scale to obtain an estimate of the highest tornado wind speed on a continuous scale in units of meters per second. The estimated wind speeds correlate at a level of .82 (.46, .95) [95% confidence interval] to wind speeds estimated independently from a doppler radar calibration. The estimated wind speeds allow analyses to be done on the tornado database that are not possible with the categorical scale. The modeled intensities can be used in climatology and in environmental and engineering applications. More work needs to be done to understand the upward trends in path length and width. The increases lead to an apparent increase in tornado intensity across all EF categories.

  18. KIR2DL2/2DL3-E35 alleles are functionally stronger than -Q35 alleles

    Science.gov (United States)

    Bari, Rafijul; Thapa, Rajoo; Bao, Ju; Li, Ying; Zheng, Jie; Leung, Wing

    2016-03-01

    KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important factor for donor selection in allogeneic hematopoietic stem cell transplantation, the molecular determinant of functional diversity among various alleles is unclear. In this study we found that KIR2DL2/L3 with glutamic acid at position 35 (E35) are functionally stronger than those with glutamine at the same position (Q35). Cytotoxicity assay showed that NK cells from HLA-C1 positive donors with KIR2DL2/L3-E35 could kill more target cells lacking their ligands than NK cells with the weaker -Q35 alleles, indicating better licensing of KIR2DL2/L3+ NK cells with the stronger alleles. Molecular modeling analysis reveals that the glutamic acid, which is negatively charged, interacts with positively charged histidine located at position 55, thereby stabilizing KIR2DL2/L3 dimer and reducing entropy loss when KIR2DL2/3 binds to HLA-C ligand. The results of this study will be important for future studies of KIR2DL2/L3-associated diseases as well as for donor selection in allogeneic stem cell transplantation.

  19. Removal of proprioception by BCI raises a stronger body ownership illusion in control of a humanlike robot.

    Science.gov (United States)

    Alimardani, Maryam; Nishio, Shuichi; Ishiguro, Hiroshi

    2016-09-22

    Body ownership illusions provide evidence that our sense of self is not coherent and can be extended to non-body objects. Studying about these illusions gives us practical tools to understand the brain mechanisms that underlie body recognition and the experience of self. We previously introduced an illusion of body ownership transfer (BOT) for operators of a very humanlike robot. This sensation of owning the robot's body was confirmed when operators controlled the robot either by performing the desired motion with their body (motion-control) or by employing a brain-computer interface (BCI) that translated motor imagery commands to robot movement (BCI-control). The interesting observation during BCI-control was that the illusion could be induced even with a noticeable delay in the BCI system. Temporal discrepancy has always shown critical weakening effects on body ownership illusions. However the delay-robustness of BOT during BCI-control raised a question about the interaction between the proprioceptive inputs and delayed visual feedback in agency-driven illusions. In this work, we compared the intensity of BOT illusion for operators in two conditions; motion-control and BCI-control. Our results revealed a significantly stronger BOT illusion for the case of BCI-control. This finding highlights BCI's potential in inducing stronger agency-driven illusions by building a direct communication between the brain and controlled body, and therefore removing awareness from the subject's own body.

  20. impact

    Directory of Open Access Journals (Sweden)

    Adámek Vítězslav

    2018-01-01

    Full Text Available The problem of non-stationary vibration of an elastic beam caused by a transverse impact loading is studied in this work. In particular, two different approaches to the derivation of analytical solution of the problem are compared. The first one is based on the Timoshenko beam theory, the latter one follows the exact two-dimensional theory. Both mentioned methods are used for finding the response of an infinite homogeneous isotropic beam. The obtained analytical results are then compared and their agreement is discussed in relation to main factors, i.e. the beam geometry, the character of loading and times and points at which the beams responses are studied.

  1. Long-Term Experience of Chinese Calligraphic Handwriting Is Associated with Better Executive Functions and Stronger Resting-State Functional Connectivity in Related Brain Regions

    Science.gov (United States)

    He, Yong; Gao, Yang; Zhang, Cuiping; Chen, Chuansheng; Bi, Suyu; Yang, Pin; Wang, Yiwen; Wang, Wenjing

    2017-01-01

    Chinese calligraphic handwriting (CCH) is a traditional art form that requires high levels of concentration and motor control. Previous research has linked short-term training in CCH to improvements in attention and memory. Little is known about the potential impacts of long-term CCH practice on a broader array of executive functions and their potential neural substrates. In this cross-sectional study, we recruited 36 practitioners with at least 5 years of CCH experience and 50 control subjects with no more than one month of CCH practice and investigated their differences in the three components of executive functions (i.e., shifting, updating, and inhibition). Valid resting-state fMRI data were collected from 31 CCH and 40 control participants. Compared with the controls, CCH individuals showed better updating (as measured by the Corsi Block Test) and inhibition (as measured by the Stroop Word-Color Test), but the two groups did not differ in shifting (as measured by a cue-target task). The CCH group showed stronger resting-state functional connectivity (RSFC) than the control group in brain areas involved in updating and inhibition. These results suggested that long-term CCH training may be associated with improvements in specific aspects of executive functions and strengthened neural networks in related brain regions. PMID:28129407

  2. EVOLUTION--taking charge and growing stronger: the design, acceptability, and feasibility of a secondary prevention empowerment intervention for young women living with HIV.

    Science.gov (United States)

    Brothers, Jennifer; Harper, Gary W; Fernandez, M Isabel; Hosek, Sybil G

    2014-01-01

    In the United States, youth of 13-24 years account for nearly a quarter of all new HIV infections, with almost 1000 young men and women being infected per month. Young women account for 20% of those new infections.This article describes the design, feasibility, and acceptability of a secondary prevention empowerment intervention for young women living with HIV entitled Young Women Taking Charge and Growing Stronger. The nine session intervention aimed to reduce secondary transmission by enhancing social and behavioral skills and knowledge pertaining to young women's physical, social, emotional, and sexual well-being,while addressing the moderating factors such as sexual inequality and power imbalances. Process evaluation data suggest that EVOLUTION is a highly acceptable and feasible intervention for young women living with HIV. Participants reported enjoying both the structure and comprehensive nature of the intervention. Both participants and interventionists reported that the intervention was highly relevant to the lives of young women living with HIV since it not only provided opportunities for them to broaden their knowledge and risk reduction skills in HIV, but it also addressed important areas that impact their daily lives such as stressors, relationships,and their emotional and social well-being. Thus, this study demonstrates that providing a gender-specific,comprehensive group-based empowerment intervention for young women living with HIV appears to be both feasible and acceptable.

  3. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

    DEFF Research Database (Denmark)

    de Rooij, Susanne R; Dekker, Jacqueline M; Kozakova, Michaela

    2009-01-01

    OBJECTIVE: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. DESIGN AND METHODS: The Relationship between Insulin...... insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity.......OBJECTIVE: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. DESIGN AND METHODS: The Relationship between Insulin...... of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis. RESULTS: Fasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds...

  4. Collective Nostalgia Is Associated With Stronger Outgroup-Directed Anger and Participation in Ingroup-Favoring Collective Action

    Directory of Open Access Journals (Sweden)

    Wing-Yee Cheung

    2017-08-01

    Full Text Available Collective nostalgia refers to longing for the way society used to be. We tested whether collective nostalgia is associated with ingroup-favoring collective action and whether this association is mediated by outgroup-directed anger and outgroup-directed contempt. We conducted an online study of Hong Kong residents (N = 111 during a large-scale democratic social movement, the Umbrella Movement, that took place in Hong Kong in 2014 in response to proposed electoral reforms by the Chinese government in Mainland China. Reported collective nostalgia for Hong Kong’s past was high in our sample and collective nostalgia predicted stronger involvement in ingroup-favoring collective action, and it did so indirectly via higher intensity of outgroup-directed anger (but not through outgroup-directed contempt. We argue that collective nostalgia has implications for strengthening ingroup-serving collective action, and we highlight the importance of arousal of group-based emotions in this process.

  5. Elite level rhythmic gymnasts have significantly more and stronger pain than peers of similar age: a prospective study.

    Science.gov (United States)

    Sabeti, Manuel; Jeremian, Lusine; Graf, Alexandra; Kandelhart, Robert

    2015-01-01

    Rhythmic gymnastics (RG) unites aesthetic, ballet-like motion, and all aspects of gymnastics. To reach elite level, girls begin at early age the intensive training. To date it is unclear if such demanding training influences the incidence and intensity of painful overuse injuries. The purpose of this study is to analyze anatomical painful regions and pain intensity in elite level rhythmic gymnasts (elRG) and compare results with an age-matched control group (CG). This prospective field study was carried out at the European Championship in RG 2013 (218 participating athletes, Vienna, Austria). Volunteering athletes were interviewed according to a preformed questionnaire. As CG secondary school pupils without any competitive sports experience were analyzed accordingly. Overall, 243 young females (144 elRG/66 % of all participants and 99 CG) were observed. ElRGs were significantly (s.) smaller, lighter, and had s. stronger pain (p < 0.001). A total of 72 % of athletes reported to have at least one painful body region compared with 52 % of CG (p < 0.001). ElRG had nearly three times more serious injuries than the CG. In all 23 % off all elRG reported to have had no access to professional medical care. ElRGs were s. more frequently (25 vs 9 %) affected at the lumbar spine and the ankle joint (17.4 vs 7 %). To our knowledge, this trial analyzes the largest cohort of elRG to date. Hence, it is clearly alluded that intensive training in RG is a significant factor causing more and stronger pain than in a CG.

  6. Strategies of Building a Stronger Sense of Community for Sustainable Neighborhoods: Comparing Neighborhood Accessibility with Community Empowerment Programs

    Directory of Open Access Journals (Sweden)

    Te-I Albert Tsai

    2014-05-01

    Full Text Available New Urbanist development in the U.S. aims at enhancing a sense of community and seeks to return to the design of early transitional neighborhoods which have pedestrian-oriented environments with retail shops and services within walking distances of housing. Meanwhile, 6000 of Taiwan’s community associations have been running community empowerment programs supported by the Council for Cultural Affairs that have helped many neighborhoods to rebuild so-called community cohesion. This research attempts to evaluate whether neighborhoods with facilities near housing and shorter travel distances within a neighborhood would promote stronger social interactions and form a better community attachment than neighborhoods that have various opportunities for residents to participate in either formal or informal social gatherings. After interviewing and surveying residents from 19 neighborhoods in Taipei’s Beitou District, and correlating the psychological sense of community with inner neighborhood’s daily travel distances and numbers of participatory activities held by community organizations under empowerment programs together with frequencies of regular individual visits and casual meetings, statistical evidence yielded that placing public facilities near residential locations is more effective than providing various programs for elevating a sense of community.

  7. Ni2P Makes Application of the PtRu Catalyst Much Stronger in Direct Methanol Fuel Cells.

    Science.gov (United States)

    Chang, Jinfa; Feng, Ligang; Liu, Changpeng; Xing, Wei

    2015-10-12

    PtRu is regarded as the best catalyst for direct methanol fuel cells, but the performance decay resulting from the loss of Ru seriously hinders commercial applications. Herein, we demonstrated that the presence of Ni2 P largely reduces Ru loss, which thus makes the application of PtRu much stronger in direct methanol fuel cells. Outstanding catalytic activity and stability were observed by cyclic voltammetry. Upon integrating the catalyst material into a practical direct methanol fuel cell, the highest maximum power density was achieved on the PtRu-Ni2P/C catalyst among the reference catalysts at different temperatures. A maximum power density of 69.9 mW cm(-2) at 30 °C was obtained on PtRu-Ni2P/C, which is even higher than the power density of the state-of-the-art commercial PtRu catalyst at 70 °C (63.1 mW cm(-2)). Moreover, decay in the performance resulting from Ru loss was greatly reduced owing to the presence of Ni2 P, which is indicative of very promising applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Attentional bias in restrictive eating disorders. Stronger attentional avoidance of high-fat food compared to healthy controls?

    Science.gov (United States)

    Veenstra, Esther M; de Jong, Peter J

    2012-02-01

    A striking feature of the restricting subtype of anorexia nervosa (AN) is that these patients are extremely successful in restricting their food intake. Possibly, they are highly efficient in avoiding attentional engagement of food cues, thereby preventing more elaborate processing of food cues and thus subsequent craving. This study examined whether patients diagnosed with restrictive eating disorders ('restricting AN-like patients'; N=88) indeed show stronger attentional avoidance of visual food stimuli than healthy controls (N=76). Attentional engagement and disengagement were assessed by means of a pictorial exogenous cueing task, and (food and neutral) pictures were presented for 300, 500, or 1000 ms. In the 500 ms condition, both restricting AN-like patients and healthy controls demonstrated attentional avoidance of high-fat food as indexed by a negative cue-validity effect and impaired attentional engagement with high-fat food, whereas no evidence was found for facilitated disengagement from high-fat food. Within the group of restricting AN-like patients, patients with relatively severe eating pathology showed relatively strong attentional engagement with low-fat food. There was no evidence for attentional bias in the 300 and 1000 ms condition. The pattern of findings indicate that attentional avoidance of high-fat food is a common phenomenon that may become counterproductive in restricting AN-like patients, as it could facilitate their restricted food intake. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Conspecific flowers of Sinapis arvensis are stronger competitors for pollinators than those of the invasive weed Bunias orientalis

    Science.gov (United States)

    Hochkirch, Axel; Mertes, Tamara; Rautenberg, Julia

    2012-03-01

    Biological invasions can affect the structure and function of ecosystems and threaten native plant species. Since most weeds rely on mutualistic relationships in their new environment, they may act as new competitors for pollinators. Pollinator competition is likely to be density dependent, but it is often difficult to disentangle competition caused by flower quality from effects caused by flower quantity. In order to test the effects of the presence and number of flowers of the invasive weed Bunias orientalis on the insect visitation rates in a native species ( Sinapis arvensis), we performed two replacement experiments using plants with standardised flower numbers. The visitation rates in S. arvensis were significantly higher than in B. orientalis and the number of insect visits dropped significantly with increasing density of S. arvensis flowers. These results suggest that intraspecific competition among flowers of S. arvensis is stronger than the competitive effect of alien flowers. As flowers of B. orientalis do not seem to distract visitors from S. arvensis, it is unlikely that pollinator competition between these two plant species plays a crucial role. However, it cannot be excluded that mass blossom stands of B. orientalis may distract flower visitors from native species.

  10. How the biotin–streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer

    Science.gov (United States)

    Chivers, Claire E.; Koner, Apurba L.; Lowe, Edward D.; Howarth, Mark

    2011-01-01

    The interaction between SA (streptavidin) and biotin is one of the strongest non-covalent interactions in Nature. SA is a widely used tool and a paradigm for protein–ligand interactions. We previously developed a SA mutant, termed Tr (traptavidin), possessing a 10-fold lower off-rate for biotin, with increased mechanical and thermal stability. In the present study, we determined the crystal structures of apo-Tr and biotin–Tr at 1.5 Å resolution. In apo-SA the loop (L3/4), near biotin's valeryl tail, is typically disordered and open, but closes upon biotin binding. In contrast, L3/4 was shut in both apo-Tr and biotin–Tr. The reduced flexibility of L3/4 and decreased conformational change on biotin binding provide an explanation for Tr's reduced biotin off- and on-rates. L3/4 includes Ser45, which forms a hydrogen bond to biotin consistently in Tr, but erratically in SA. Reduced breakage of the biotin–Ser45 hydrogen bond in Tr is likely to inhibit the initiating event in biotin's dissociation pathway. We generated a Tr with a single biotin-binding site rather than four, which showed a simi-larly low off-rate, demonstrating that Tr's low off-rate was governed by intrasubunit effects. Understanding the structural features of this tenacious interaction may assist the design of even stronger affinity tags and inhibitors. PMID:21241253

  11. Meta-Analysis of the Effect of Bowel Preparation on Adenoma Detection: Early Adenomas Affected Stronger than Advanced Adenomas.

    Science.gov (United States)

    Sulz, Michael C; Kröger, Arne; Prakash, Meher; Manser, Christine N; Heinrich, Henriette; Misselwitz, Benjamin

    2016-01-01

    Low-quality bowel preparation reduces efficacy of colonoscopy. We aimed to summarize effects of bowel preparation on detection of adenomas, advanced adenomas and colorectal cancer. A systematic literature search was performed regarding detection of colonic lesions after normal and low-quality bowel preparation. Reported bowel preparation quality was transformed to the Aronchick scale with its qualities "excellent", "good", "fair", "poor", and "insufficient" or "optimal" (good/excellent), "suboptimal" (fair/poor/insufficient), "adequate" (good/excellent/fair) and "inadequate" (poor/insufficient). We identified two types of studies: i) Comparative studies, directly comparing lesion detection according to bowel preparation quality, and ii) repeat colonoscopy studies, reporting results of a second colonoscopy after previous low-quality preparation. The detection of early adenomas was reduced with inadequate vs. adequate bowel preparation (Odds Ratio (OR) 0.53, CI: 0.46-0.62, panalysis resulted in smaller confidence intervals compared to earlier studies. Classifying the bowel-preparation quality as suboptimal vs. optimal led to the same qualitative conclusion (OR: 0.81, CI: 0.74-0.89, pdetection were insufficient. Inadequate bowel preparation affects detection of early colonic lesions stronger than advanced lesions.

  12. Risk factors for obesity: further evidence for stronger effects on overweight children and adolescents compared to normal-weight subjects.

    Directory of Open Access Journals (Sweden)

    Andreas Beyerlein

    Full Text Available BACKGROUND: We recently showed that in preschoolers risk factors for overweight show stronger associations with BMI in children with high BMI values. However, it is unclear whether these findings might also pertain to adolescents. METHODS: We extracted data on 3-10 year-old (n = 7,237 and 11-17 year-old (n = 5,986 children from a representative cross-sectional German health survey (KiGGS conducted between 2003 and 2006 and calculated quantile regression models for each age group. We used z-scores of children's body mass index (BMI as outcome variable and maternal BMI, maternal smoking in pregnancy, low parental socioeconomic status, exclusive formula-feeding and high TV viewing time as explanatory variables. RESULTS: In both age groups, the estimated effects of all risk factors except formula-feeding on BMI z-score were greatest for children with the highest BMI z-score. The median BMI z-score of 11-17 year-old children with high TV viewing time, for example, was 0.11 [95% CI: 0.03, 0.19] units higher than the median BMI z-score of teenage children with low TV viewing time. This risk factor was associated with an average difference of 0.18 [0.06, 0.30] units at the 90(th percentile of BMI z-score and of 0.20 [0.07, 0.33] units at the 97(th percentile. CONCLUSIONS: We confirmed that risk factors for childhood overweight are associated with greater shifts in the upper parts of the children's BMI distribution than in the middle and lower parts. These findings pertain also to teenagers and might possibly help to explain the secular shift in the upper BMI percentiles in children and adolescents.

  13. Can an amine be a stronger acid than a carboxylic acid? The surprisingly high acidity of amine-borane complexes.

    Science.gov (United States)

    Martín-Sómer, Ana; Lamsabhi, Al Mokhtar; Yáñez, Manuel; Dávalos, Juan Z; González, Javier; Ramos, Rocío; Guillemin, Jean-Claude

    2012-12-03

    The gas-phase acidity of a series of amine-borane complexes has been investigated through the use of electrospray mass spectrometry (ESI-MS), with the application of the extended Cooks kinetic method, and high-level G4 ab initio calculations. The most significant finding is that typical nitrogen bases, such as aniline, react with BH(3) to give amine-borane complexes, which, in the gas phase, have acidities as high as those of either phosphoric, oxalic, or salicylic acid; their acidity is higher than many carboxylic acids, such as formic, acetic, and propanoic acid. Indeed the complexation of different amines with BH(3) leads to a substantial increase (from 167 to 195 kJ mol(-1)) in the intrinsic acidity of the system; in terms of ionization constants, this increase implies an increase as large as fifteen orders of magnitude. Interestingly, this increase in acidity is almost twice as large as that observed for the corresponding phosphine-borane analogues. The agreement between the experimental and the G4-based calculated values is excellent. The analysis of the electron-density rearrangements of the amine and the borane moieties indicates that the dative bond is significantly stronger in the N-deprotonated anion than in the corresponding neutral amine-borane complex, because the deprotonated amine is a much better electron donor than the neutral amine. On the top of that, the newly created lone pair on the nitrogen atom in the deprotonated species, conjugates with the BN bonding pair. The dispersion of the extra electron density into the BH(3) group also contributes to the increased stability of the deprotonated species. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Ipr1 modified BCG as a novel vaccine induces stronger immunity than BCG against tuberculosis infection in mice.

    Science.gov (United States)

    Wang, Yuwei; Yang, Chun; He, Yonglin; Zhan, Xingxing; Xu, Lei

    2016-08-01

    Tuberculosis is a major challenge to global public health. However, the Bacille Calmette‑Guérin (BCG), the only vaccine available against tuberculosis, has been questioned for the low protective effect. The present study used the mouse gene intracellular pathogen resistance I (Ipr1) gene to alter the current BCG vaccine and evaluated its immunity effect against tuberculosis. This study also investigated the intrinsic relationships of Ipr1 and innate immunity. The reformed BCG (BCGi) carrying the Ipr1 gene was constructed. The mice were intranasally challenged with the M. tuberculosis H37Rv strain after vaccination with BCGi. Protection efficacy of the vaccine was assessed by the organ coefficient, bacterial load and pathological changes in the lung. The differential expression of 113 immune‑related genes between BCGi and BCG groups were detected by an oligo microarray. According to the results of organ coefficient, bacterial load and pathological changes in the organization, BCGi had been shown to have stronger protective effects against M. tuberculosis than BCG. The oligo microarray and reverse transcription‑quantitative polymerase chain reaction further revealed that the Ipr1 gene could upregulate the expression of 13 genes, including a >3‑fold increase in Toll‑like receptor (TLR)4 and 10‑fold increase in surfactant protein D (sftpd). The two genes not only participate in innate immunity against pathogens, but also are closely interrelated. Ipr1 could activate the TLR4 and sftpd signaling pathway and improve the innate immunity against tuberculosis, therefore Ipr1 modified BCG may be a candidate vaccine against M. tuberculosis.

  15. 37% Phosphoric Acid Induced Stronger Matrix Metalloproteinase-8 Expression of the Dental Pulp than 19% Ethylene Diamine Tetraacetic Acid

    Directory of Open Access Journals (Sweden)

    Nadie Fatimatuzzahro

    2014-11-01

    Full Text Available Etching agents such as ethylene diamine tetraacetic acid (EDTA and phosphoric acid which are widely used in adhesive restoration system aimed to increase for retention of restorative materials, may act a chemical irritant that induce inflammation of dental pulp. Inflammation is a body response against irritant and infectious agents. Matrix metalloproteinase-8, the major collagenolytic enzyme, degrades collagen type 1. This enzyme is expressed in low level in normal condition, however, the expression will increase during inflammation. The purpose of the present research was to study the effect of 19% EDTA and 37% phosphoric acid application as an etching agents on the MMP-8 expression of dental pulp. Forty-five male Sprague Dawley rats were divided into 3 groups. Cavity preparation was made on the occlusal surface of maxillary first molar using a round diamond bur. 19% EDTA, 37% phosphoric acid, and distilled water were applied on the surface of the cavity of the teeth in group I, II, and III subsequently. The cavity then filed by glass ionomer cements. The rats were sacrified at 1, 3, 5, 7, and 14 days after the treatment (n=3 for each day. The specimens were then processed histologically. Immunohistochemical (IHC analysis was performed using rabbit anti rat MMP-8 polyclonal antibody to examine MMP-8 expression and HE (Hematoxylen Eosin staining to observe the number of macrophages. The results showed 37% phosphoric acid application induced stronger expression of MMP-8 and higher number of macrophages than 19% EDTA. The strongest expression of MMP-8 seems on 5 days after the treatment where the highest number of macrophages were also found.

  16. Carbon sink activity is stronger under grazing than under mowing: results from a paired eddy flux towers experiment

    Science.gov (United States)

    Pintér, Krisztina; Balogh, János; Koncz, Péter; Hidy, Dóra; Cserhalmi, Dóra; Papp, Marianna; Fóti, Szilvia; Nagy, Zoltán

    2014-05-01

    Effect of grazing vs. mowing on carbon balance of a grassland was investigated by a paired eddy towers (one of them measuring the grazed, the another the mowed treatment) experiment at the Bugacpuszta sandy grassland site (HU-Bug, 46.69° N, 19.6° E, 114m asl, 10.4 ° C annual mean temperature, 562 mm annual precipitation sum) located in the Hungarian Plain. Eddy covariance measurements started in July, 2002. The area of the mowed treatment is 1 ha, it is located within the grazed treatment (500 ha). Electric fence was set up around the selected area in spring of 2011. Study years include 2011, 2012 and 2013. The pasture is managed extensively (average grazing pressure of 0.5 cattle per hectare), the cattle herd regularly took several kilometres during a grazing day. Annual net ecosystem exchange (NEE) of the grassland is strongly limited by precipitation, there were 2 source years within the 11 years (2003-2013) of measurements, during which the average annual balance was -109 gCm-2year-1 with standard deviation of 106 gCm-2year-1. Carbon sink activity of the grassland was stronger in the grazed treatment than in the mowed treatment during the three year study period (paired t-test, P=0.058). In the grazed treatment the average sink strength was -142.8 ±40 gCm-2year-1, while in the mowed treatment the average sink strength was -61.5 ±46.5 gCm-2year-1. Differences of carbon balances between the treatments were positively correlated to the annual sum of evapotranspiration (ET), while ETs of the treatments were almost identical (differences within a 10mm year-1 range) in each study year. Water use efficiency in the mowed treatment was 44% of that in the grazed treatment (P=0.045) as a result of the differences in sink capacity. The higher sensitivity to drought by the mowed treatment manifested in decreased sink capacity during summer and in decreased regeneration capacity during autumn rains as shown by the cumulative NEE in the different years. Minor but

  17. Stronger diversity effects with increased environmental stress : A study of multitrophic interactions between oak, powdery mildew and ladybirds

    NARCIS (Netherlands)

    Dillen, Mathias; Smit, Christian; Buyse, Martijn; Höfte, Monica; De Clercq, Patrick; Verheyen, Kris

    2017-01-01

    Recent research has suggested that increasing neighbourhood tree species diversity may mitigate the impact of pests or pathogens by supporting the activities of their natural enemies and/or reducing the density of available hosts. In this study, we attempted to assess these mechanisms in a

  18. Are the hydrogen bonds of RNA (.U) stronger than those of DNA (A.T)? A quantum mechanics study

    Czech Academy of Sciences Publication Activity Database

    Pérez, A.; Šponer, Jiří; Jurečka, Petr; Hobza, Pavel; Luque, Javier F.; Orozco, Modesto

    2005-01-01

    Roč. 11, č. 17 (2005), s. 5062-5066 ISSN 0947-6539 R&D Projects: GA ČR(CZ) GA203/05/0009 Institutional research plan: CEZ:AV0Z50040507 Keywords : density functional calculations * DNA * hydrogen bonds Subject RIV: BO - Biophysics Impact factor: 4.907, year: 2005

  19. Pine weevil feeding on Norway spruce bark has a stronger impact on needle VOC emissions than enhanced ultraviolet-B radiation

    Energy Technology Data Exchange (ETDEWEB)

    Blande, James D. [Department of Environmental Science, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio (Finland)], E-mail: James.Blande@uku.fi; Turunen, Katariina [Department of Environmental Science, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio (Finland)], E-mail: ksturune@hytti.uku.fi; Holopainen, Jarmo K. [Department of Environmental Science, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio (Finland)], E-mail: Jarmo.Holopainen@uku.fi

    2009-01-15

    Plants can respond physiologically to damaging ultraviolet-B radiation by altering leaf chemistry, especially UV absorbing phenolic compounds. However, the effects on terpene emissions have received little attention. We conducted two field trials in plots with supplemented UV-B radiation and assessed the influence of feeding by pine weevils, Hylobius abietis L., on volatile emissions from 3-year old Norway spruce trees (Picea abies L. Karst.). We collected emissions from branch tips distal to the feeding weevils, and from whole branches including the damage sites. Weevil feeding clearly induced the emission of monoterpenes and sesquiterpenes, particularly linalool and (E)-{beta}-farnesene, from branch tips, and the sums of monoterpenes and sesquiterpenes emitted by whole branches were substantially increased. We discovered little effect of UV-B radiation up to 30% above the ambient level on volatile emissions from branch tips distal to damage sites, but there was a possible effect on bark emissions from damage sites. - Chronic exposure to enhanced UV-B radiation has little effect on volatile emissions of Norway spruce.

  20. Pine weevil feeding on Norway spruce bark has a stronger impact on needle VOC emissions than enhanced ultraviolet-B radiation

    International Nuclear Information System (INIS)

    Blande, James D.; Turunen, Katariina; Holopainen, Jarmo K.

    2009-01-01

    Plants can respond physiologically to damaging ultraviolet-B radiation by altering leaf chemistry, especially UV absorbing phenolic compounds. However, the effects on terpene emissions have received little attention. We conducted two field trials in plots with supplemented UV-B radiation and assessed the influence of feeding by pine weevils, Hylobius abietis L., on volatile emissions from 3-year old Norway spruce trees (Picea abies L. Karst.). We collected emissions from branch tips distal to the feeding weevils, and from whole branches including the damage sites. Weevil feeding clearly induced the emission of monoterpenes and sesquiterpenes, particularly linalool and (E)-β-farnesene, from branch tips, and the sums of monoterpenes and sesquiterpenes emitted by whole branches were substantially increased. We discovered little effect of UV-B radiation up to 30% above the ambient level on volatile emissions from branch tips distal to damage sites, but there was a possible effect on bark emissions from damage sites. - Chronic exposure to enhanced UV-B radiation has little effect on volatile emissions of Norway spruce

  1. Stronger pack warnings predict quitting more than weaker ones: finding from the ITC Malaysia and Thailand surveys

    OpenAIRE

    Fathelrahman, Ahmed I; Li, Lin; Borland, Ron; Yong, Hua-Hie; Omar, Maizurah; Awang, Rahmat; Sirirassamee, Buppha; Fong, Geoffrey T; Hammond, David

    2013-01-01

    Background We examined the impact of cigarette pack warning labels on interest in quitting and subsequent quit attempts among adult smokers in Malaysia and Thailand. Methods Two overlapping cohorts of adults who reported smoking factory- made cigarettes from Malaysia and Thailand were interviewed face-to-face (3189 were surveyed at baseline and 1781 re-contacted at Wave 2; 2361 current smokers were surveyed at Wave 2 and 1586 re-contacted at Wave 3). In Thailand at baseline, large text only w...

  2. Hydrogen bonds of RNA are stronger than those of DNA, but NMR monitors only presence of methyl substituent in uracil/thymine

    NARCIS (Netherlands)

    Swart, M.; Fonseca Guerra, C.; Bickelhaupt, F.M.

    2004-01-01

    Recently, Vakonakis and LiWang (J. Am. Chem. Soc. 2004, 126, 5688) reported experimental evidence for stronger hydrogen bonds in RNA A:U than in DNA A:T base pairs, which was based on differences in NMR shielding for adenine C2. We have analyzed the proposed correlation between NMR shielding and

  3. 'I feel stronger and younger all the time'-perspectives of elderly kidney transplant recipients: thematic synthesis of qualitative research.

    Science.gov (United States)

    Pinter, Jule; Hanson, Camilla S; Craig, Jonathan C; Chapman, Jeremy R; Budde, Klemens; Halleck, Fabian; Tong, Allison

    2016-09-01

    , providing support to alleviate the debilitating impacts of immunosuppression and addressing fears about deteriorating health and graft failure may improve satisfaction and outcomes in elderly kidney transplant recipients. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  4. Using social capital to construct a conceptual International Classification of Functioning, Disability, and Health Children and Youth version-based framework for stronger inclusive education policies in Europe.

    Science.gov (United States)

    Maxwell, Gregor; Koutsogeorgou, Eleni

    2012-02-01

    Inclusive education is part of social inclusion; therefore, social capital can be linked to an inclusive education policy and practice. This association is explored in this article, and a practical measure is proposed. Specifically, the World Health Organization's International Classification of Functioning, Disability and Health Children and Youth Version (ICF-CY) is proposed as the link between social capital and inclusive education. By mapping participation and trust indicators of social capital to the ICF-CY and by using the Matrix to Analyse Functioning in Education Systems (MAFES) to analyze the functioning of inclusive education policies and systems, a measure for stronger inclusive education policies is proposed. Such a tool can be used for policy planning and monitoring to ensure better inclusive education environments. In conclusion, combining enhanced social capital linked to stronger inclusive education policies, by using the ICF-CY, can lead to better health and well-being for all.

  5. More concerns and stronger beliefs about the necessity of medication in patients with acromegaly are associated with negative illness perceptions and impairment in quality of life.

    Science.gov (United States)

    Andela, Cornelie D; Biermasz, Nienke R; Kaptein, Adrian A; Pereira, Alberto M; Tiemensma, Jitske

    2015-10-01

    Patients with acromegaly can be treated with surgery, radiotherapy and/or medical treatment. In general, patients' beliefs about medication are associated with illness perceptions, a contributory factor of Quality of Life (QoL). At present, there are no quantitative studies on medication beliefs in patients with acromegaly. Here, we aimed to examine possible associations between medication beliefs, illness perceptions, and QoL. Furthermore we aimed to explore whether illness perceptions of patients with remission of acromegaly receiving medical treatment differ from patients without medical treatment. Cross-sectional evaluation of 73 patients with remission of acromegaly (n = 28 patients with medication, n = 45 without medication). The Beliefs about Medicines Questionnaire (BMQ), Illness Perception Questionnaire-Revised (IPQ-R), EuroQoL-5D, and AcroQoL were used for the assessment. Stronger beliefs about the necessity of medical treatment and stronger concerns about the adverse effects were associated with attributing more symptoms to acromegaly, perceiving more negative consequences, and having a stronger belief in a cyclical timeline (BMQ, all P IPQ-R, P = 0.002). Negative medication beliefs were related to more negative illness perceptions and worse disease-specific QoL. Patients receiving medical treatment for acromegaly tend to perceive a more chronic timeline of their disease, compared to patients with remission without medical treatment. These psychological factors need to be taken into account when treating patients and developing a psychosocial education program aiming to improve QoL. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African-Americans than Caucasians

    DEFF Research Database (Denmark)

    Nielsen, Julie Vendelbo; Olesen, Rasmus Hansen; Lauridsen, Jesper Krogh

    2016-01-01

    . Using microarray data analysis from 145 neurologically sound adults, this study investigated the association between body mass index (BMI) and ABCB1 expression in the frontal cortex. Increasing BMI values were associated with a statistically significantly reduced expression of ABCB1. Investigation...... of DNA methylation patterns in a subgroup of 52 individuals found that the methylation/expression ratios of ABCB1 were unaffected by increasing BMI values. Interestingly, the effect of BMI on ABCB1 expression appeared stronger in African Americans than in Caucasians.The Pharmacogenomics Journal advance...

  7. Are melanized feather barbs stronger?

    Science.gov (United States)

    Butler, Michael; Johnson, Amy S

    2004-01-01

    Melanin has been associated with increased resistance to abrasion, decreased wear and lowered barb breakage in feathers. But, this association was inferred without considering barb position along the rachis as a potentially confounding variable. We examined the cross-sectional area, breaking force, breaking stress, breaking strain and toughness of melanized and unmelanized barbs along the entire rachis of a primary feather from an osprey (Pandion haliaetus). Although breaking force was higher for melanized barbs, breaking stress (force divided by cross-sectional area) was greater for unmelanized barbs. But when position was considered, all mechanical differences between melanized and unmelanized barbs disappeared. Barb breaking stress, breaking strain and toughness decreased, and breaking stiffness increased, distally along the rachis. These proximal-distal material property changes are small and seem unlikely to affect flight performance of barbs. Our observations of barb bending, breaking and morphology, however, lead us to propose a design principle for barbs. We propose that, by being thicker-walled dorso-ventrally, the barb's flexural stiffness is increased during flight; but, by allowing for twisting when loaded with dangerously high forces, barbs firstly avoid failure by bending and secondly avoid complete failure by buckling rather than rupturing.

  8. A stronger, more supranational Union

    DEFF Research Database (Denmark)

    Beach, Derek

    2012-01-01

    Are we witnessing a transformation of the EU from a strong supranational institution into a weaker Union dominated by governments? This chapter analyzes developments in the past two decades, investigating whether we have seen a shift in power from the EU to member state governments. Is there a sh......Are we witnessing a transformation of the EU from a strong supranational institution into a weaker Union dominated by governments? This chapter analyzes developments in the past two decades, investigating whether we have seen a shift in power from the EU to member state governments....... Is there a shift in the EU towards a new, more intergovernmental Union? The argument in this chapter is that what we are seeing is actually the gradual strengthening of the supranational character of the Union, following a typical trajectory. When a policy area is first included as part of the EU, decision...

  9. A stronger perfume for LPG

    Energy Technology Data Exchange (ETDEWEB)

    Willcox, C.K.

    1996-11-01

    The odorisation of Liquefied Petroleum Gas (LPG) is undertaken to improve the safe use and transport of this popular fuel. Effective LPG odorisation should enable leaks to be detected by any person with a normal sense of smell before gas concentrations reach a hazardous level. The objective is identical to that for odorising natural gas. However, the physical characteristics of propane and butane present particular difficulties. These do not occur with natural gas, which has a dynamic, flowing, simple-phase system. (author)

  10. A stronger perfume for LPG

    International Nuclear Information System (INIS)

    Willcox, C.K.

    1996-01-01

    The odorisation of Liquefied Petroleum Gas (LPG) is undertaken to improve the safe use and transport of this popular fuel. Effective LPG odorisation should enable leaks to be detected by any person with a normal sense of smell before gas concentrations reach a hazardous level. The objective is identical to that for odorising natural gas. However, the physical characteristics of propane and butane present particular difficulties. These do not occur with natural gas, which has a dynamic, flowing, simple-phase system. (author)

  11. Working Longer Makes Students Stronger?

    DEFF Research Database (Denmark)

    Jensen, Vibeke Myrup

    classroom hours in literacy and maths on ninth grade (aged 16) student performance in writing and maths, respectively. Using population data for Denmark in 2003-2006, I exploit unique policy-induced variation in classroom hours.On average, the reform changed classroom hours by 2.2-3.3% in literacy and maths...

  12. The polar 2e/12c bond in phenalenyl-azaphenalenyl hetero-dimers: Stronger stacking interaction and fascinating interlayer charge transfer

    Science.gov (United States)

    Zhong, Rong-Lin; Xu, Hong-Liang; Li, Zhi-Ru

    2016-08-01

    An increasing number of chemists have focused on the two-electron/multicenter bond (2e/mc) that was first introduced to interpret the bonding mechanism of radical dimers. Herein, we report the polar two-electron/twelve center (2e/12c) bonding character in a series of phenalenyl-azaphenalenyl radical hetero-dimers. Interestingly, the bonding energy of weaker polar hetero-dimer (P-TAP) is dominated by the overlap of the two different singly occupied molecular orbital of radicals, while that of stronger polar hetero-dimer (P-HAP) is dominated by the electrostatic attraction. Results show that the difference between the electronegativity of the monomers plays a prominent role in the essential attribution of the polar 2e/12c bond. Correspondingly, a stronger stacking interaction in the hetero-dimer could be effectively achieved by increasing the difference of nitrogen atoms number between the monomers. It is worthy of note that an interesting interlayer charge transfer character is induced in the polar hetero-dimers, which is dependent on the difference between the electronegativity of the monomers. It is our expectation that the new knowledge about the bonding nature of radical hetero-dimers might provide important information for designing radical based functional materials with various applications.

  13. Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs

    Science.gov (United States)

    Wu, XianMing; Hurst, Laurence D.

    2015-01-01

    The nearly neutral theory predicts that small effective population size provides the conditions for weakened selection. This is postulated to explain why our genome is more “bloated” than that of, for example, yeast, ours having large introns and large intergene spacer. If a bloated genome is also an error prone genome might it, however, be the case that selection for error-mitigating properties is stronger in our genome? We examine this notion using splicing as an exemplar, not least because large introns can predispose to noisy splicing. We thus ask whether, owing to genomic decay, selection for splice error-control mechanisms is stronger, not weaker, in species with large introns and small populations. In humans much information defining splice sites is in cis-exonic motifs, most notably exonic splice enhancers (ESEs). These act as splice-error control elements. Here then we ask whether within and between-species intron size is a predictor of the commonality of exonic cis-splicing motifs. We show that, as predicted, the proportion of synonymous sites that are ESE-associated and under selection in humans is weakly positively correlated with the size of the flanking intron. In a phylogenetically controlled framework, we observe, also as expected, that mean intron size is both predicted by Ne.μ and is a good predictor of cis-motif usage across species, this usage coevolving with splice site definition. Unexpectedly, however, across taxa intron density is a better predictor of cis-motif usage than intron size. We propose that selection for splice-related motifs is driven by a need to avoid decoy splice sites that will be more common in genes with many and large introns. That intron number and density predict ESE usage within human genes is consistent with this, as is the finding of intragenic heterogeneity in ESE density. As intronic content and splice site usage across species is also well predicted by Ne.μ, the result also suggests an unusual circumstance in

  14. Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection

    DEFF Research Database (Denmark)

    Borges, Alvaro Humberto Diniz; O'Connor, Jemma L; Phillips, Andrew N

    2016-01-01

    BACKGROUND: Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels are linked to adverse outcomes in human immunodeficiency virus (HIV) infection, but the strength of their associations with different clinical end points warrants investigation. METHODS: Participants...... receiving standard of care in 2 HIV trials with measured biomarker levels were followed to ascertain all-cause death, non-AIDS-related death, AIDS, cardiovascular disease (CVD), and non-AIDS-defining malignancies. Hazard ratios (HRs) and 95% confidence intervals (CIs) of each end point for quartiles and log......-dimer (P = .20) as a predictor for different end points. CONCLUSIONS: IL-6 is a stronger predictor of fatal events than of CVD and non-AIDS-defining malignancies. Adjuvant antiinflammatory and antithrombotic therapies should be tested in HIV-infected individuals....

  15. CDC'S Testing Makes Us Stronger (TMUS) Campaign: Was Campaign Exposure Associated With HIV Testing Behavior Among Black Gay and Bisexual Men?

    Science.gov (United States)

    Habarta, Nancy; Boudewyns, Vanessa; Badal, Hannah; Johnston, Jennie; Uhrig, Jennifer; Green, Donata; Ruddle, Paul; Rosenthal, Jacqueline; Stryker, Jo Ellen

    2017-06-01

    This study assessed exposure among Black gay, bisexual, and other men who have sex with men (BMSM) to a communication campaign, Testing Makes Us Stronger (TMUS), and its association with HIV testing to determine campaign effectiveness. Data from an online survey (N = 3,105) were analyzed using propensity score weight-adjusted logistic regression to examine the effect of exposure on HIV testing. Among BMSM aged 18-44 (n = 702), 43.2% reported TMUS exposure. The majority of those exposed were aged 25-34 (54%), HIV-negative (65%), and had some college education (87%). TMUS exposure was associated with reported increased HIV testing behaviors at 6- and 12-month frequencies. Communication campaigns with clear implementation strategies, focused objectives, and online and event presence can be associated with longer-term outcomes such as HIV testing.

  16. Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders.

    Science.gov (United States)

    Li, Hai; Xue, Zhong; Ellmore, Timothy M; Frye, Richard E; Wong, Stephen T C

    2014-02-01

    Neuroimaging has uncovered both long-range and short-range connectivity abnormalities in the brains of individuals with autism spectrum disorders (ASD). However, the precise connectivity abnormalities and the relationship between these abnormalities and cognition and ASD symptoms have been inconsistent across studies. Indeed, studies find both increases and decreases in connectivity, suggesting that connectivity changes in the ASD brain are not merely due to abnormalities in specific connections, but rather, due to changes in the structure of the network in which the brain areas interact (i.e., network topology). In this study, we examined the differences in the network topology between high-functioning ASD patients and age and gender matched typically developing (TD) controls. After quantitatively characterizing the whole-brain connectivity network using diffusion tensor imaging (DTI) data, we searched for brain regions with different connectivity between ASD and TD. A measure of oral language ability was then correlated with the connectivity changes to determine the functional significance of such changes. Whole-brain connectivity measures demonstrated greater local connectivity and shorter path length in ASD as compared to TD. Stronger local connectivity was found in ASD, especially in regions such as the left superior parietal lobule, the precuneus and angular gyrus, and the right supramarginal gyrus. The relationship between oral language ability and local connectivity within these regions was significantly different between ASD and TD. Stronger local connectivity was associated with better performance in ASD and poorer performance in TD. This study supports the notion that increased local connectivity is compensatory for supporting cognitive function in ASD. Copyright © 2012 Wiley Periodicals, Inc.

  17. Brain responds to another person's eye blinks in a natural setting-the more empathetic the viewer the stronger the responses.

    Science.gov (United States)

    Mandel, Anne; Helokunnas, Siiri; Pihko, Elina; Hari, Riitta

    2015-10-01

    An observer's brain is known to respond to another person's small nonverbal signals, such as gaze shifts and eye blinks. Here we aimed to find out how an observer's brain reacts to a speaker's eye blinks in the presence of other audiovisual information. Magnetoencephalographic brain responses along with eye gaze were recorded from 13 adults who watched a video of a person telling a story. The video was presented first without sound (visual), then with sound (audiovisual), and finally the audio story was presented with a still-frame picture on the screen (audio control). The viewers mainly gazed at the eye region of the speaker. Their saccades were suppressed at about 180 ms after the start of the speaker's blinks, a subsequent increase of saccade occurence to the base level, or higher, at around 340 ms. The suppression occurred in visual and audiovisual conditions but not during the control audio presentation. Prominent brain responses to blinks peaked in the viewer's occipital cortex at about 250 ms, with no differences in mean peak amplitudes or latencies between visual and audiovisual conditions. During the audiovisual, but not visual-only, presentation, the responses were the stronger the more empathetic the subject was according to the Empathic Concern score of the Interpersonal Reactivity Index questionnaire (Spearman's rank correlation, 0.73). The other person's eye blinks, nonverbal signs that often go unnoticed, thus elicited clear brain responses even in the presence of attention-attracting audiovisual information from the narrative, with stronger responses in people with higher empathy scores. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  18. Project Stronger Together: Protocol to Test a Dyadic Intervention to Improve Engagement in HIV Care Among Sero-Discordant Male Couples in Three US Cities.

    Science.gov (United States)

    Stephenson, Rob; Suarez, Nicolas A; Garofalo, Robert; Hidalgo, Marco A; Hoehnle, Samuel; Thai, Jennie; Mimiaga, Matthew J; Brown, Emily; Bratcher, Anna; Wimbly, Taylor; Sullivan, Patrick

    2017-08-31

    An estimated one- to-two-thirds of new human immunodeficiency virus (HIV) infections among US men who have sex with men (MSM) occur within the context of primary partnerships. Despite this fact, there remains a lack of prevention interventions that focus on male sero-discordant dyads. Interventions that provide male couples with skills to manage HIV risk, and to support each other towards active engagement in HIV prevention and care, are urgently needed. The objective of this paper is to describe the protocol for an innovative dyadic intervention (Stronger Together) that combines couples' HIV testing and dyadic adherence counseling to improve treatment adherence and engagement in care among HIV sero-discordant male couples in the United States. The research activities involve a prospective randomized controlled trial (RCT) of approximately 165 venue- and clinic-recruited sero-discordant male couples (330 individuals: 165 HIV sero-negative and 165 HIV sero-positive). Couples randomized into the intervention arm receive couples' HIV counseling and testing plus dyadic adherence counseling, while those randomized to the control arm receive individual HIV counseling and testing. The study takes place in three cities: Atlanta, GA (study site Emory University); Boston, MA (study site The Fenway Institute); and Chicago, IL (study site Ann & Robert H. Lurie Children's Hospital of Chicago). Cohort recruitment began in 2015. Couples are followed prospectively for 24 months, with study assessments at baseline, 6, 12, 18, and 24 months. Stronger Together was launched in August 2014. To date, 160 couples (97% of the target enrollment) have been enrolled and randomized. The average retention rate across the three sites is 95%. Relationship dissolution has been relatively low, with only 13 couples breaking up during the RCT. Of the 13 couples who have broken up, 10 of the 13 HIV-positive partners have been retained in the cohort; none of these HIV-positive partners have enrolled

  19. Executive Control Over Cognition: Stronger and Earlier Rule-Based Modulation of Spatial Category Signals in Prefrontal Cortex Relative to Parietal Cortex

    Science.gov (United States)

    Goodwin, Shikha J.; Blackman, Rachael K.; Sakellaridi, Sofia

    2012-01-01

    Human cognition is characterized by flexibility, the ability to select not only which action but which cognitive process to engage to best achieve the current behavioral objective. The ability to tailor information processing in the brain to rules, goals, or context is typically referred to as executive control, and although there is consensus that prefrontal cortex is importantly involved, at present we have an incomplete understanding of how computational flexibility is implemented at the level of prefrontal neurons and networks. To better understand the neural mechanisms of computational flexibility, we simultaneously recorded the electrical activity of groups of single neurons within prefrontal and posterior parietal cortex of monkeys performing a task that required executive control of spatial cognitive processing. In this task, monkeys applied different spatial categorization rules to reassign the same set of visual stimuli to alternative categories on a trial-by-trial basis. We found that single neurons were activated to represent spatially defined categories in a manner that was rule dependent, providing a physiological signature of a cognitive process that was implemented under executive control. We found also that neural signals coding rule-dependent categories were distributed between the parietal and prefrontal cortex—however, not equally. Rule-dependent category signals were stronger, more powerfully modulated by the rule, and earlier to emerge in prefrontal cortex relative to parietal cortex. This suggests that prefrontal cortex may initiate the switch in neural representation at a network level that is important for computational flexibility. PMID:22399773

  20. Malnutrition Increases With Obesity and Is a Stronger Independent Risk Factor for Postoperative Complications: A Propensity-Adjusted Analysis of Total Hip Arthroplasty Patients.

    Science.gov (United States)

    Fu, Michael C; D'Ambrosia, Christopher; McLawhorn, Alexander S; Schairer, William W; Padgett, Douglas E; Cross, Michael B

    2016-11-01

    Obesity is frequently associated with complications after total hip arthroplasty (THA) and is often concomitant with malnutrition. The purpose of this study was to investigate the independent morbidity risk of malnutrition relative to obesity. The National Surgical Quality Improvement Program from 2005 to 2013 was queried for elective primary THA cases. Malnutrition was defined as albumin malnutrition with 30-day outcomes. A total of 40,653 THA cases were identified, of which 20,210 (49.7%) had preoperative albumin measurements. Propensity score adjustment successfully reduced potential selection bias, with P > .05 for differences between those with and without albumin data. Malnutrition incidence increased from 2.8% in obese I to 5.7% in obese III patients. With multivariable propensity-adjusted logistic regression, malnutrition was a more robust predictor than any obesity class for any postoperative complication(s) (odds ratio [OR] 1.61, 95% confidence interval [CI] 1.25-2.08), major complications (OR 1.63, 95% CI 1.21-2.19), respiratory complications (OR 2.35, 95% CI 1.27-4.37), blood transfusions (OR 1.71, 95% CI 1.44-2.03), and extended length of stay (OR 1.35, 95% CI 1.14-1.59). Malnutrition incidence increased significantly from obese I to obese III patients and was a stronger and more consistent predictor than obesity of complications after THA. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Complex Karyotype is a Stronger Predictor than Del(17p) for Inferior Outcome in Relapsed or Refractory CLL Patients Treated with Ibrutinib-Based Regimens

    Science.gov (United States)

    Thompson, Philip A.; O’Brien, Susan M.; Wierda, William G.; Ferrajoli, Alessandra; Stingo, Francesco; Smith, Susan C.; Burger, Jan A.; Estrov, Zeev; Jain, Nitin; Kantarjian, Hagop M.; Keating, Michael J.

    2016-01-01

    Background Ibrutinib is active in patients with relapsed/refractory (R/R) CLL. In patients treated with ibrutinib for R/R CLL, del(17p) identified by interphase fluorescence in situ hybridization (FISH) is associated with inferior progression-free survival, despite equivalent initial response rates. Del(17p) is frequently associated with complex metaphase karyotype (CKT); the prognostic significance of CKT in ibrutinib-treated patients has not been reported. Methods We reviewed 88 patients treated for R/R CLL at MD Anderson Cancer Center with investigational ibrutinib-based regimens from 2010–2013. Pre-treatment FISH and Lipopolysaccharide-stimulated metaphase cytogenetic analysis were performed on bone marrow. Results Adequate pre-treatment metaphase karyotype was available for 56/88 patients. Karyotype was complex in 21 of 56 cases; 17 of the 21 had del(17p) by FISH. Overall response rate, including partial remission with persistent lymphocytosis, was 94% with 17% complete responses. In multivariable analysis (MVA), only CKT was significantly associated with event-free survival (EFS) [HR 6.6 (1.7–25.6), p=0.006]. Fludarabine-refractory CLL [HR 6.9 (1.8–27.1), p=0.005] and CKT [HR 5.9 (1.6–22.2), p=0.008] were independently associated with inferior overall survival (OS) in MVA. Del(17p) by FISH was not significantly associated with EFS or OS in MVA. Conclusions CKT is a powerful predictor of outcome in ibrutinib-treated patients with R/R CLL and may be a stronger predictor of biological behavior than del(17p) by FISH. Given their relatively poor outcomes, patients with CKT are ideal candidates for studies of consolidative treatment strategies or novel treatment combinations. PMID:26193999

  2. Spatial Autocorrelation Can Generate Stronger Correlations between Range Size and Climatic Niches Than the Biological Signal - A Demonstration Using Bird and Mammal Range Maps.

    Science.gov (United States)

    Boucher-Lalonde, Véronique; Currie, David J

    2016-01-01

    Species' geographic ranges could primarily be physiological tolerances drawn in space. Alternatively, geographic ranges could be only broadly constrained by physiological climatic tolerances: there could generally be much more proximate constraints on species' ranges (dispersal limitation, biotic interactions, etc.) such that species often occupy a small and unpredictable subset of tolerable climates. In the literature, species' climatic tolerances are typically estimated from the set of conditions observed within their geographic range. Using this method, studies have concluded that broader climatic niches permit larger ranges. Similarly, other studies have investigated the biological causes of incomplete range filling. But, when climatic constraints are measured directly from species' ranges, are correlations between species' range size and climate necessarily consistent with a causal link? We evaluated the extent to which variation in range size among 3277 bird and 1659 mammal species occurring in the Americas is statistically related to characteristics of species' realized climatic niches. We then compared how these relationships differed from the ones expected in the absence of a causal link. We used a null model that randomizes the predictor variables (climate), while retaining their broad spatial autocorrelation structure, thereby removing any causal relationship between range size and climate. We found that, although range size is strongly positively related to climatic niche breadth, range filling and, to a lesser extent, niche position in nature, the observed relationships are not always stronger than expected from spatial autocorrelation alone. Thus, we conclude that equally strong relationships between range size and climate would result from any processes causing ranges to be highly spatially autocorrelated.

  3. Spatial Autocorrelation Can Generate Stronger Correlations between Range Size and Climatic Niches Than the Biological Signal — A Demonstration Using Bird and Mammal Range Maps

    Science.gov (United States)

    Boucher-Lalonde, Véronique; Currie, David J.

    2016-01-01

    Species’ geographic ranges could primarily be physiological tolerances drawn in space. Alternatively, geographic ranges could be only broadly constrained by physiological climatic tolerances: there could generally be much more proximate constraints on species’ ranges (dispersal limitation, biotic interactions, etc.) such that species often occupy a small and unpredictable subset of tolerable climates. In the literature, species’ climatic tolerances are typically estimated from the set of conditions observed within their geographic range. Using this method, studies have concluded that broader climatic niches permit larger ranges. Similarly, other studies have investigated the biological causes of incomplete range filling. But, when climatic constraints are measured directly from species’ ranges, are correlations between species’ range size and climate necessarily consistent with a causal link? We evaluated the extent to which variation in range size among 3277 bird and 1659 mammal species occurring in the Americas is statistically related to characteristics of species’ realized climatic niches. We then compared how these relationships differed from the ones expected in the absence of a causal link. We used a null model that randomizes the predictor variables (climate), while retaining their broad spatial autocorrelation structure, thereby removing any causal relationship between range size and climate. We found that, although range size is strongly positively related to climatic niche breadth, range filling and, to a lesser extent, niche position in nature, the observed relationships are not always stronger than expected from spatial autocorrelation alone. Thus, we conclude that equally strong relationships between range size and climate would result from any processes causing ranges to be highly spatially autocorrelated. PMID:27855201

  4. Critical high-dimensional state transitions in cell populations or why cancers follow the principle ``What does not kill me makes me stronger''

    Science.gov (United States)

    Huang, Sui

    Transitions between high-dimensional attractor states in the quasi-potential landscape of the gene regulatory network, induced by environmental perturbations and/or facilitated by mutational rewiring of the network, underlie cell phenotype switching in development as well as in cancer progression, including acquisition of drug-resistant phenotypes. Considering heterogeneous cell populations as statistical ensembles of cells, and single-cell resolution gene expression profiling of cell populations undergoing a cell phenotype shift allow us now to map the topography of the landscape and its distortion. From snapshots of single-cell expression patterns of a cell population measured during major transitions we compute a quantity that identifies symmetry-breaking destabilization of attractors (bifurcation) and concomitant dimension-reduction of the state space manifold (landscape distortion) which precede critical transitions to new attractor states. The model predicts, and we show experimentally, the almost inevitable generation of aberrant cells associated with such critical transitions in multi-attractor landscapes: therapeutic perturbations which seek to push cancer cells to the apoptotic state, almost always produce ``rebellious'' cells which move in the ``opposite direction'': instead of dying they become more stem-cell-like and malignant. We show experimentally that the inadvertent generation of more malignant cancer cells by therapy indeed results from transition of surviving (but stressed) cells into unforeseen attractor states and not simply from selection of inherently more resistant cells. Thus, cancer cells follow not so much Darwin, as generally thought (survival of the fittest), but rather Nietzsche (What does not kill me makes me stronger). Supported by NIH (NCI, NIGMS), Alberta Innovates.

  5. Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders.

    Science.gov (United States)

    Clark, Sarah V; Mittal, Vijay A; Bernard, Jessica A; Ahmadi, Aral; King, Tricia Z; Turner, Jessica A

    2018-03-01

    Impaired clinical insight (CI) is a common symptom of psychotic disorders and a promising treatment target. However, to date, our understanding of how variability in CI is tied to underlying brain dysfunction in the clinical high-risk period is limited. Developing a stronger conception of this link will be a vital first step for efforts to determine if CI can serve as a useful prognostic indicator. The current study investigated whether variability in CI is related to major brain networks in adolescents and young adults at ultra high-risk (UHR) of developing psychosis. Thirty-five UHR youth were administered structured clinical interviews as well as an assessment for CI and underwent resting-state magnetic resonance imaging scans. Functional connectivity was calculated in the default mode network (DMN) and fronto-parietal network (FPN), two major networks that are dysfunctional in psychosis and are hypothesized to affect insight. Greater DMN connectivity between the posterior cingulate/precuneus and ventromedial prefrontal cortex (DMN) was related to poorer CI (R 2 =0.399). There were no significant relationships between insight and the FPN. This is the first study to relate a major brain network to clinical insight before the onset of psychosis. Findings are consistent with evidence if a hyperconnected DMN in schizophrenia and UHR, and similar to a previous study of insight and connectivity in schizophrenia. Results suggest that a strongly connected DMN may be related to poor self-awareness of subthreshold psychotic symptoms in UHR adolescents and young adults. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Analogues of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide

    Science.gov (United States)

    Grassi, Lucia; Maisetta, Giuseppantonio; Maccari, Giuseppe; Esin, Semih; Batoni, Giovanna

    2017-04-01

    The frog skin-derived peptide Temporin 1Tb (TB) has gained increasing attention as novel antimicrobial agent for the treatment of antibiotic-resistant and/or biofilm-mediated infections. Nevertheless, such a peptide possesses a preferential spectrum of action against Gram-positive bacteria. In order to improve the therapeutic potential of TB, the present study evaluated the antibacterial and antibiofilm activities of two TB analogues against medically relevant bacterial species. Of the two analogues, TB_KKG6A has been previously described in the literature, while TB_L1FK is a new analogue designed by us through statistical-based computational strategies. Both TB analogues displayed a faster and stronger bactericidal activity than the parental peptide, especially against Gram-negative bacteria in planktonic form. Differently from the parental peptide, TB_KKG6A and TB_L1FK were able to inhibit the formation of Staphylococcus aureus biofilms by more than 50% at 12 μM, while only TB_KKG6A prevented the formation of Pseudomonas aeruginosa biofilms at 24 μM. A marked antibiofilm activity against preformed biofilms of both bacterial species was observed for the two TB analogues when used in combination with EDTA. Analysis of synergism at the cellular level suggested that the antibiofilm activity exerted by the peptide-EDTA combinations against mature biofilms might be due mainly to a disaggregating effect on the extracellular matrix in the case of S. aureus, and to a direct activity on biofilm-embedded cells in the case of P. aeruginosa. Both analogues displayed a low hemolytic effect at the active concentrations and, overall, TB_L1FK resulted less cytotoxic towards mammalian cells. Collectively, the results obtained demonstrated that subtle changes in the primary sequence of TB may provide TB analogues that, used alone or in combination with adjuvant molecules such as EDTA, exhibit promising features against both planktonic and biofilm cells of medically relevant

  7. Do Corporate Control and Product Market Competition Lead to Stronger Productivity Growth? Evidence from Market-Oriented and Blockholder-Based Governance Regimes

    NARCIS (Netherlands)

    Koke, J.; Renneboog, L.D.R.

    2003-01-01

    This study investigates the impact of corporate governance and product market competition on total factor productivity growth for two large samples of German and UK firms. In poorly performing UK firms, the presence of strong outside blockholders lead to substantial increases in productivity.

  8. Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.R. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada)]. E-mail: djohnson@advancedcyclotron.com; Watt, R. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Kovac, B. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Zyuzin, A. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Van Lier, E. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Erdman, K.L. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Gyles, Wm. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Sabaiduc, V. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); McQuarrie, S.A. [Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, T6G 1Z2 (Canada); Wilson, J. [Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, T6G 1Z2 (Canada); Backhouse, C. [Department of Electrical Engineering, University of Alberta, Edmonton, AB (Canada); Gelbart, Wm. [Advanced System Design, C22, S6, RR1, Garden Bay, BC, V0N 1S0 (Canada); Kuo, T. [4654 N. Larwin Ave., Concorde, CA 94521 United States (United States)

    2007-08-15

    The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed.

  9. Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

    Science.gov (United States)

    Johnson, R. R.; Watt, R.; Kovac, B.; Zyuzin, A.; Van Lier, E.; Erdman, K. L.; Gyles, Wm.; Sabaiduc, V.; McQuarrie, S. A.; Wilson, J.; Backhouse, C.; Gelbart, Wm.; Kuo, T.

    2007-08-01

    The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed.

  10. Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

    International Nuclear Information System (INIS)

    Johnson, R.R.; Watt, R.; Kovac, B.; Zyuzin, A.; Van Lier, E.; Erdman, K.L.; Gyles, Wm.; Sabaiduc, V.; McQuarrie, S.A.; Wilson, J.; Backhouse, C.; Gelbart, Wm.; Kuo, T.

    2007-01-01

    The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed

  11. Experimental study of the molecular beam destruction by beam-beam and beam-background scattering

    International Nuclear Information System (INIS)

    Bossel, U.; Dettleff, G.

    1974-01-01

    The extraction of flow properties related to the molecular motion normal to stream lines of an expanding gas jet from observed intensity profiles of supersonic beams is critically assessed. The perturbation of the profile curves by various effects is studied for a helium beam. Exponential laws appear to describe scattering effects to a satisfactory degree

  12. Beam-beam deflections as an interaction point diagnostic for the SLC

    International Nuclear Information System (INIS)

    Bambade, P.; Erickson, R.

    1986-05-01

    A technique is described for non-destructive measurement and monitoring of the steering offset of the electron and positron beams at the interaction point of the SLC, based on using stripline beam-position monitors to measure the centroid of one beam as it is deflected by the opposing beam. This technique is also expected to provide diagnostic information related to the spot size of the micron-size beams

  13. Effects of beam-beam collisions on storage-ring performance - a pedagogical review

    International Nuclear Information System (INIS)

    Schonfeld, J.F.

    1983-01-01

    This paper presents a survey of the experimental and theoretical literature on colliding-beam effects in both leptonic and hadronic storage rings. For the most part, this literature is rather technical and, to the novice, both obscurely written and hard to locate. Although there have already been several symposia on the subject, as well as a number of reviews for specialists there has up till now been no unified and pedagogical exposition. The present work represents an attempt to fill this gap. The material is grouped into four major areas: observational phenomenology, computer simulation, mathematical background, and theoretical models. 113 references, 36 figures

  14. Time-dependent field equations for paraxial relativistic electron beams: Beam Research Program

    International Nuclear Information System (INIS)

    Sharp, W.M.; Yu, S.S.; Lee, E.P.

    1987-01-01

    A simplified set of field equations for a paraxial relativistic electron beam is presented. These equations for the beam electrostatic potential phi and pinch potential Phi identical to A/sub z/ - phi retain previously neglected time-dependent terms and for axisymmetric beams reduce exactly to Maxwell's equations

  15. A Study of the Effect of Beam-Beam Interactions on CESR Optics

    CERN Document Server

    Crittenden, James Arthur; Rubin, David

    2005-01-01

    The CESR storage ring facility has begun operation in an energy region which allows high-statistics investigation of charm-quark bound states. Experience during the first year has shown that the effects of parasitic crossings in the pretzel orbits present an important factor in injection efficiency, in the beam lifetime and stored current limits. We compare the results of beam dynamics and tracking calculations which quantify the effects of these parasitic crossings on optics and dynamic aperture for the injected and stored trajectories to observations of beam behavior.

  16. Luminosity Loss due to Beam Distortion and the Beam-Beam Instability

    CERN Document Server

    Wu, Juhao; Raubenheimer, Tor O; Seryi, Andrei; Sramek, Christopher K

    2005-01-01

    In a linear collider, sources of emittance dilution such as transverse wakefields or dispersive errors will couple the vertical phase space to the longitudinal position within the beam (the so-called ‘banana effect'). When the Intersection Point (IP) disruption parameter is large, these beam distortions will be amplified by a single bunch kink instability which will lead to luminosity loss. We study this phenomena both analytically using linear theory and via numerical simulation. In particular, we examine the dependence of the luminosity loss on the wavelength of the beam distortions and the disruption parameter. This analysis may prove useful when optimizing the vertical disruption parameter for luminosity operation with given beam distortions.

  17. Magic Lenses for RHIC: Compensating Beam-beam Interaction (488th Brookhaven Lecture)

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yun [BNL Collider-Accelerator Department

    2013-07-17

    Scientists at Brookhaven Lab’s Relativistic Heavy Ion Collider (RHIC) smash atomic particles together to understand more about why the physical world works the way it does. Increasing rates of particle collisions, or luminosity, at RHIC is no small challenge, but the results—more data for better clues—are crucial for scientists trying answer big questions about the origins of matter and mass. When scientists at RHIC collide protons, they don’t hope for a head-on crash by focusing only two particles roaring toward each other from opposite directions. For all intents and purposes, that would be impossible. The scientists can smash protons because they significantly increase the likelihood of collisions by steering hundreds of billions clumped into bunches, which at RHIC are about 3.5 meters long and less than 1 millimeter tall. The particles of these bunches are all positively charged, so when they interact, they repel outwardly—think how magnets repel when their same poles are pushed together. Although this decreases the density of each bunch, reducing luminosity, scientists in Brookhaven Lab’s Collider-Accelerator Department (C-AD) have a solution. After more than seven years of development, the scientists have designed an electron-lens system that uses electrons’ negative charges to attract positively charged proton bunches and minimize their repelling tendencies. Combined with other upgrades to the RHIC accelerator complex, these lenses are important components in efforts towards the major task of doubling the luminosity for proton-proton collisions.

  18. The NOD2 p.Leu1007fsX1008 mutation (rs2066847 is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.

    Directory of Open Access Journals (Sweden)

    Fabian Schnitzler

    Full Text Available Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD (Cell 2013;155:57-69. The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery.We genotyped 550 CD patients for rs12212067 (FOXO3A and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses.No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847 was highly associated with penetrating CD (p = 0.01, the development of fistulas (p = 0.01 and stenoses (p = 0.01, and ileal disease localization (p = 0.03. Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5, while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35. 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p = 0.007.In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847, in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A rs12212067 SNP for a mild disease course on an individual patient level despite

  19. The benefit of expecting no conflict--Stronger influence of self-generated than cue-induced conflict expectations on Stroop performance.

    Science.gov (United States)

    Kemper, Maike; Gaschler, Robert; Schwager, Sabine; Schubert, Torsten

    2016-01-01

    The role of expectations in sequential adaptation to cognitive conflict has been debated controversially in prior studies. On the one hand, a sequential congruency effect (SCE) has been reported for trials in which participants expect a repetition of conflict level. On the other hand, conflict level expectations vs. the SCE have been shown to develop differentially across runs of trials with the same conflict level, arguing against the theory that the SCE is purely driven by expectation. The current verbal Stroop experiment addresses this controversy by two means. First, we tested which specific type of expectation (cue-induced expectations vs. self-generated predictions) might affect the SCE. Second, we assessed the impact of expectation on the SCE as well as the development of SCE and expectation with congruency level run length in one design. We observed a dissociation between expectations and SCE, demonstrating that the SCE is not exclusively driven by expectations. At the same time, we found evidence that (self-generated) expectations do have an impact on the SCE. Our data document especially high performance for one specific combination of task events: congruent trial accompanied by congruent prediction and conflict level repetition. Our results are in line with theories attributing conflict adaptation effects to the "adaption to the lack of conflict". We discuss our results in a broader context of theories about conflict monitoring. Copyright © 2015. Published by Elsevier B.V.

  20. Site properties have a stronger influence than fire severity on ectomycorrhizal fungi and associated N-cycling bacteria in regenerating post-beetle-killed lodgepole pine forests.

    Science.gov (United States)

    Kennedy, Nabla M; Robertson, Susan J; Green, D Scott; Scholefield, Scott R; Arocena, Joselito M; Tackaberry, Linda E; Massicotte, Hugues B; Egger, Keith N

    2015-09-01

    Following a pine beetle epidemic in British Columbia, Canada, we investigated the effect of fire severity on rhizosphere soil chemistry and ectomycorrhizal fungi (ECM) and associated denitrifying and nitrogen (N)-fixing bacteria in the root systems of regenerating lodgepole pine seedlings at two site types (wet and dry) and three fire severities (low, moderate, and high). The site type was found to have a much larger impact on all measurements than fire severity. Wet and dry sites differed significantly for almost all soil properties measured, with higher values identified from wet types, except for pH and percent sand that were greater on dry sites. Fire severity caused few changes in soil chemical status. Generally, bacterial communities differed little, whereas ECM morphotype analysis revealed ectomycorrhizal diversity was lower on dry sites, with a corresponding division in community structure between wet and dry sites. Molecular profiling of the fungal ITS region confirmed these results, with a clear difference in community structure seen between wet and dry sites. The ability of ECM fungi to colonize seedlings growing in both wet and dry soils may positively contribute to subsequent regeneration. We conclude that despite consecutive landscape disturbances (mountain pine beetle infestation followed by wildfire), the "signature" of moisture on chemistry and ECM community structure remained pronounced.

  1. The association of obesity with sex hormone-binding globulin is stronger than the association with ageing – implications for the interpretation of total testosterone measurements

    Science.gov (United States)

    Cooper, Lori A.; Page, Stephanie T.; Amory, John K.; Anawalt, Bradley D.; Matsumoto, Alvin M.

    2016-01-01

    Summary Objective Total testosterone concentrations are influenced by sex hormone-binding globulin (SHBG) concentrations, which are decreased by obesity and increased with ageing. Therefore, we sought to understand and compare the associations of ageing and obesity with SHBG. Design We performed a retrospective, cross-sectional analysis of the associations of obesity and age on SHBG and testosterone measurements in men being evaluated for hypogonadism. Patients, Measurements and Analysis A total of 3671 men who underwent laboratory testing for testosterone deficiency from the Veterans Administration Puget Sound Health Care System from 1997 through 2007 was included. Univariate and multivariate linear regression modelling of the associations between age and body mass index (BMI) and SHBG was performed. Results Obesity was associated with a significantly lower SHBG [β = −1·26 (95% CI −1·14, −1·38) nmol/l] per unit increase in BMI. In contrast, ageing was associated with a significantly increased SHBG [β = 0·46 (95% CI 0·39, 0·53) nmol/l per year] (P obesity with lower SHBG was two to three times larger than the association of ageing with increased SHBG in both univariate and multivariate modelling. On average, obese men (BMI >30 kg/m2) had significantly lower SHBG and total testosterone concentrations than nonobese men [(mean ± SD) SHBG: 36 ± 22 vs 50 ± 27 nmol/l and total testosterone: 10·5 ± 5·4 nmol/l vs 14·1 ± 7·4 nmol/l; (P testosterone concentrations did not differ between obese and nonobese men. Conclusions We found that the association between obesity and lowered SHBG is greater than the association of ageing with increased SHBG. These competing effects may impact total testosterone measurements for the diagnosis of low testosterone, particularly in obese men. PMID:25777143

  2. The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements.

    Science.gov (United States)

    Cooper, Lori A; Page, Stephanie T; Amory, John K; Anawalt, Bradley D; Matsumoto, Alvin M

    2015-12-01

    Total testosterone concentrations are influenced by sex hormone-binding globulin (SHBG) concentrations, which are decreased by obesity and increased with ageing. Therefore, we sought to understand and compare the associations of ageing and obesity with SHBG. We performed a retrospective, cross-sectional analysis of the associations of obesity and age on SHBG and testosterone measurements in men being evaluated for hypogonadism. A total of 3671 men who underwent laboratory testing for testosterone deficiency from the Veterans Administration Puget Sound Health Care System from 1997 through 2007 was included. Univariate and multivariate linear regression modelling of the associations between age and body mass index (BMI) and SHBG was performed. Obesity was associated with a significantly lower SHBG [β = -1·26 (95% CI -1·14, -1·38) nmol/l] per unit increase in BMI. In contrast, ageing was associated with a significantly increased SHBG [β = 0·46 (95% CI 0·39, 0·53) nmol/l per year] (P obesity with lower SHBG was two to three times larger than the association of ageing with increased SHBG in both univariate and multivariate modelling. On average, obese men (BMI >30 kg/m(2)) had significantly lower SHBG and total testosterone concentrations than nonobese men [(mean ± SD) SHBG: 36 ± 22 vs 50 ± 27 nmol/l and total testosterone: 10·5 ± 5·4 nmol/l vs 14·1 ± 7·4 nmol/l; (P testosterone concentrations did not differ between obese and nonobese men. We found that the association between obesity and lowered SHBG is greater than the association of ageing with increased SHBG. These competing effects may impact total testosterone measurements for the diagnosis of low testosterone, particularly in obese men. © 2015 John Wiley & Sons Ltd.

  3. Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation.

    Science.gov (United States)

    Goheen, M M; Wegmüller, R; Bah, A; Darboe, B; Danso, E; Affara, M; Gardner, D; Patel, J C; Prentice, A M; Cerami, C

    2016-12-01

    Iron deficiency causes long-term adverse consequences for children and is the most common nutritional deficiency worldwide. Observational studies suggest that iron deficiency anemia protects against Plasmodium falciparum malaria and several intervention trials have indicated that iron supplementation increases malaria risk through unknown mechanism(s). This poses a major challenge for health policy. We investigated how anemia inhibits blood stage malaria infection and how iron supplementation abrogates this protection. This observational cohort study occurred in a malaria-endemic region where sickle-cell trait is also common. We studied fresh RBCs from anemic children (135 children; age 6-24months; hemoglobin Anemia substantially reduced the invasion and growth of both laboratory and field strains of P. falciparum in vitro (~10% growth reduction per standard deviation shift in hemoglobin). The population level impact against erythrocytic stage malaria was 15.9% from anemia compared to 3.5% for sickle-cell trait. Parasite growth was 2.4 fold higher after 49days of iron supplementation relative to baseline (panemia protects African children against falciparum malaria, an effect that is substantially greater than the protection offered by sickle-cell trait. Iron supplementation completely reversed the observed protection and hence should be accompanied by malaria prophylaxis. Lower hemoglobin levels typically seen in populations of African descent may reflect past genetic selection by malaria. National Institute of Child Health and Development, Bill and Melinda Gates Foundation, UK Medical Research Council (MRC) and Department for International Development (DFID) under the MRC/DFID Concordat. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

  4. Impacts of climate change in the Netherlands

    International Nuclear Information System (INIS)

    Bresser, A.H.M.; Berk, M.M.; Van den Born, G.J.; Van Bree, L.; Van Gaalen, F.W.; Ligtvoet, W.; Van Minnen, J.G.; Witmer, M.C.H.

    2005-10-01

    The main conclusion of the study on the title subject is that the impacts of climatic change in the Netherlands are still limited. However, the impacts will be stronger in the next decades and will be even problematic at the end of this century. In this book an overview is given of probable changes in the climate for the Netherlands, danger for flooding in specific areas of the Netherlands, changes of the nature, impacts for agriculture, tourism and recreation, and industry and businesses, and risks for public health [nl

  5. Impact Strength of Glass and Glass Ceramic

    Science.gov (United States)

    Bless, S.; Tolman, J.

    2009-12-01

    Strength of glass and glass ceramic was measured with a bar impact technique. High-speed movies show regions of tensile and compressive failure. The borosilicate glass had a compressive strength of at least 2.2 GPa, and the glass ceramic at least 4 GPa. However, the BSG was much stronger in tension than GC. In ballistic tests, the BSG was the superior armor.

  6. Computer-assisted health impact assessment for intersectoral health policy

    NARCIS (Netherlands)

    Mooy, J. M.; Gunning-Schepers, L. J.

    2001-01-01

    Intersectoral health policy implies negotiations with politicians outside the health sector. Health politicians have a stronger position if they can quantify health impact. In this Dutch case-study we used a computer simulation approach to answer the following questions: Which anti-tobacco

  7. Application of GIS to assess rainfall variability impacts on crop yield ...

    African Journals Online (AJOL)

    SERVER

    2007-09-19

    Sep 19, 2007 ... The scientific evidence on rainfall variability with its significant impacts on crop yield is now stronger than ever. It is even more so on maize that serves as staple food in most parts of Sub-Sahara Africa. Hence, this study aim at examines and map spatio-temporal impacts of rainfall variability on water.

  8. Can absence make a team grow stronger?

    Science.gov (United States)

    Majchrzak, Ann; Malhotra, Arvind; Stamps, Jeffrey; Lipnack, Jessica

    2004-05-01

    Some projects have such diverse requirements that they need a variety of specialists to work on them. But often the best-qualified specialists are scattered around the globe, perhaps at several companies. Remarkably, an extensive benchmarking study reveals, it isn't necessary to bring team members together to get their best work. In fact, they can be even more productive if they stay separated and do all their collaborating virtually. The scores of successful virtual teams the authors examined didn't have many of the psychological and practical obstacles that plagued their more traditional, face-to-face counterparts. Team members felt freer to contribute--especially outside their established areas of expertise. The fact that such groups could not assemble easily actually made their projects go faster, as people did not wait for meetings to make decisions, and individuals, in the comfort of their own offices, had full access to their files and the complementary knowledge of their local colleagues. Reaping those advantages, though, demanded shrewd management of a virtual team's work processes and social dynamics. Rather than depend on videoconferencing or e-mail, which could be unwieldy or exclusionary, successful virtual teams made extensive use of sophisticated online team rooms, where everyone could easily see the state of the work in progress, talk about the work in ongoing threaded discussions, and be reminded of decisions, rationales, and commitments. Differences were most effectively hashed out in tele-conferences, which team leaders also used to foster group identity and solidarity. When carefully managed in this way, the clash of perspectives led not to acrimony but, rather, to fundamental solutions, turning distance and diversity into competitive advantage.

  9. Essentially stronger - 1999 EPCOR annual report

    International Nuclear Information System (INIS)

    1999-01-01

    The year 1999 has been a year of consolidation for EPCOR Utilities, uniting the the former brands of Edmonton Power, Aquaalta and Eltec under a new single brand, EPCOR, to provide Edmontonians with a safe, high quality and reliable essential service at competitive prices . The company is building for growth by augmenting its product line with natural gas and green power, accessing new capital, proceeding with new projects at various sites, creating EPCOR Power Development Corporation with an ambitious mandate to grow beyond the Utilities traditional service areas. In proof of that, EPCOR Water Services won a strategically important contract in Port Hardy, BC; EPCOR Technologies also has been involved in projects beyond Alberta. As a sign of confidence in the company, the City of Edmonton voted to retain ownership of the company in July. The Utility also managed to win national awards for both safety and environmental practices and is the first utility company to have all its generating plants meet ISO 14001 standards. During 2000 the company will tackle the evolution of industry restructuring , will explore more diverse financial structures to accommodate growth and the increase in demand for services to make sure that EPCOR will be a leading provider of electric power and natural gas services as the era of deregulated competitive electrical services in Alberta begins in 2001. This report provides details of the achievements of the company's business units in 1999, accompanied by a consolidated financial statement

  10. Accelerator Sector - together we're stronger

    CERN Document Server

    2002-01-01

    From 1 January onwards, the Accelerator Sector will be reorganised into two new divisions AB and AT. We talked to the leaders of these two divisions, Steve Myers and Philippe Lebrun, about this reorganisation.

  11. Nursing is stronger when we work together.

    Science.gov (United States)

    Catton, Howard

    2017-01-11

    There are some striking similarities between Brexit and the election of Donald Trump as president of the United States: anger with an out-of-touch establishment, a desire to take back control and many people feeling left behind by globalisation.

  12. Citius, Altius, Fortius: Faster, Higher, Stronger

    Science.gov (United States)

    2013-06-01

    yang theories or sexual symbolism. Further, the visceral reaction to same sex hand holding is the basis for gender, ethnic, class, or national hatred...categories-reappear-in-todays-china-276381.html. 68 Jinxia, Women, Sport and Society in Modern China, 76. 69 Jung Chang, Wild Swans: Three Daughters of...women, do exemplify Confucian 143 Jeffrey Richey, “Gender and Sexuality ,” Patheos Library, (n.d

  13. Essentially stronger -1999 EPCOR annual report

    International Nuclear Information System (INIS)

    2000-01-01

    This annual report provides details of the financial operations of EPCOR, the newly formed utility, combining together three essential elements of modern living --electric power, water and natural gas-- as a single entity. In addition to this report on financial management, there are two companion reports on environmental performance entitled E ssential Balance', and on contributions to the community with the title of 'Essential Spirit'. While this report focuses on the Corporation's financial performance, it also provides a summary on the Corporation's growth, operational excellence, regulatory matters, environmental achievements and management of the Corporation's people resources. The financial report includes the customary consolidated financial statements, the auditor's report, and management's discussion and analysis of the financial report. Revenues for 1999 totalled just over one billion dollars ($978 million in 1998); net income was $116 million ($121 million in 1998); operating expenses were higher than in 1998 ($765 million versus $642 million) due to higher natural gas prices; capital spending was $198 million, compared to $153 million in 1998. Operations, maintenance, and administrative costs were also higher in 1999 due to higher employee costs across the EPCOR Group, one-time costs associated with EPCOR's master branding initiative, Y2K testing and remediation, and increased business development costs

  14. Chemical reaction due to stronger Ramachandran interaction

    Indian Academy of Sciences (India)

    fulfilling this condition, these atoms still need to have an overall strong attractive interaction (either before or after the collision) to form the required transition state. For example, the transition state by definition gives equal probability for the reaction to go either way (to form reactant atoms, or the reaction product). There-.

  15. Stronger links between CERN and South Africa

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    iThemba LABS in South Africa is a research facility that, about twenty years ago, started to treat oncological patients with particle beams. Its collaboration with CERN has steadily grown over the years. After becoming a member of the ALICE and ATLAS Collaborations, today iThemba LABS is planning to buy a new medical-use cyclotron proton facility, and is seeking to strengthen its links with CERN and Europe also in this field by collaborating with ENLIGHT. The cyclotron will be dedicated to proton therapy – the only one of its kind in the southern hemisphere.   iThemba LABS (Laboratory for Accelerator Based Sciences) was established near Cape Town, South Africa almost 50 years ago as the continent's base for the Southern Universities Nuclear Institute that is now used mainly for material science research. In the 1980s, iThemba built a 200MeV cyclotron and, following its construction, in the early 1990s branched into a new scientific field: radiation and nuclear medicine. ...

  16. Minimal residual method stronger than polynomial preconditioning

    Energy Technology Data Exchange (ETDEWEB)

    Faber, V.; Joubert, W.; Knill, E. [Los Alamos National Lab., NM (United States)] [and others

    1994-12-31

    Two popular methods for solving symmetric and nonsymmetric systems of equations are the minimal residual method, implemented by algorithms such as GMRES, and polynomial preconditioning methods. In this study results are given on the convergence rates of these methods for various classes of matrices. It is shown that for some matrices, such as normal matrices, the convergence rates for GMRES and for the optimal polynomial preconditioning are the same, and for other matrices such as the upper triangular Toeplitz matrices, it is at least assured that if one method converges then the other must converge. On the other hand, it is shown that matrices exist for which restarted GMRES always converges but any polynomial preconditioning of corresponding degree makes no progress toward the solution for some initial error. The implications of these results for these and other iterative methods are discussed.

  17. Chemical reaction due to stronger Ramachandran interaction

    Indian Academy of Sciences (India)

    tum mechanical phenomena that made biological life possible on earth, which can also be manipulated to discover novel 'green' chemistry, and to avoid 'toxic' ..... diagrams for clarity, but their analyses apply regardless of whether a given system is one-, two- or three-dimensional. particular, (A) depicts isotropic polarization ...

  18. Sloshing impact in roofed tanks

    International Nuclear Information System (INIS)

    Uras, R.A.

    1995-01-01

    A large number of high-level waste (HLW) storage tanks exists in various tank farms. Seismic activities at those locations may cause significant sloshing in HLW tanks. These tanks are covered to avoid any spilling during large amplitude earthquakes. However, large amplitude sloshing may result in impact on the cover or the roof of the tank. Hence, a better understanding of the impact phenomenon is necessary to assess the safety of the tanks currently in existence, and to establish design guidelines for future designs. A pressure based formulation is derived to model sloshing impact in roofed tanks. It is incorporated into Argonne's in-house finite element code FLUSTR-ANL. A numerical test case with a harmonic input excitation is studied. The simulation results indicate that linear behavior is preserved beyond the first impact, and some mesh distortion is observed following a stronger second impact. During the impact, the displacement of the contacting surface nodes remains constant, and the velocities are reduced to zero. An identification of impacting nodes is possible from the dynamic pressures induced in surface elements

  19. Sloshing impact in roofed tanks

    International Nuclear Information System (INIS)

    Uras, R.A.

    1995-01-01

    A large number of high-level waste (HLW) storage tanks exists in various tank farms. Seismic activities at those locations may cause significant sloshing in HLW tanks. These tanks are covered to avoid any spilling during large amplitude earthquakes. However, large amplitude sloshing may result in impact on the cover or the roof of the tank. Hence, a better understanding of the impact phenomenon is necessary to assess the safety of the tanks currently in existence, and to establish design guidelines for future designs. A pressure based formulation is derived to model sloshing impact in roared tanks. It is incorporated into Argonne's in-house finite element code FLUSTR-ANL. A numerical test case with a harmonic input excitation is studied. The simulation results indicate that linear behavior is preserved beyond the first impact, and some mesh distortion is observed following a stronger second impact. During the impact, the displacement of the contacting surface nodes remains constant, and the velocities are reduced to zero. An identification of impacting nodes is possible from the dynamic pressures induced in surface elements

  20. In roots of Arabidopsis thaliana, the damage-associated molecular pattern AtPep1 is a stronger elicitor of immune signalling than flg22 or the chitin heptamer.

    Directory of Open Access Journals (Sweden)

    Lorenzo Poncini

    Full Text Available Plants interpret their immediate environment through perception of small molecules. Microbe-associated molecular patterns (MAMPs such as flagellin and chitin are likely to be more abundant in the rhizosphere than plant-derived damage-associated molecular patterns (DAMPs. We investigated how the Arabidopsis thaliana root interprets MAMPs and DAMPs as danger signals. We monitored root development during exposure to increasing concentrations of the MAMPs flg22 and the chitin heptamer as well as of the DAMP AtPep1. The tissue-specific expression of defence-related genes in roots was analysed using a toolkit of promoter::YFPN lines reporting jasmonic acid (JA-, salicylic acid (SA-, ethylene (ET- and reactive oxygen species (ROS- dependent signalling. Finally, marker responses were analysed during invasion by the root pathogen Fusarium oxysporum. The DAMP AtPep1 triggered a stronger activation of the defence markers compared to flg22 and the chitin heptamer. In contrast to the tested MAMPs, AtPep1 induced SA- and JA-signalling markers in the root and caused a severe inhibition of root growth. Fungal attack resulted in a strong activation of defence genes in tissues close to the invading fungal hyphae. The results collectively suggest that AtPep1 presents a stronger danger signal to the Arabidopsis root than the MAMPs flg22 and chitin heptamer.

  1. In roots of Arabidopsis thaliana, the damage-associated molecular pattern AtPep1 is a stronger elicitor of immune signalling than flg22 or the chitin heptamer.

    Science.gov (United States)

    Poncini, Lorenzo; Wyrsch, Ines; Dénervaud Tendon, Valérie; Vorley, Thomas; Boller, Thomas; Geldner, Niko; Métraux, Jean-Pierre; Lehmann, Silke

    2017-01-01

    Plants interpret their immediate environment through perception of small molecules. Microbe-associated molecular patterns (MAMPs) such as flagellin and chitin are likely to be more abundant in the rhizosphere than plant-derived damage-associated molecular patterns (DAMPs). We investigated how the Arabidopsis thaliana root interprets MAMPs and DAMPs as danger signals. We monitored root development during exposure to increasing concentrations of the MAMPs flg22 and the chitin heptamer as well as of the DAMP AtPep1. The tissue-specific expression of defence-related genes in roots was analysed using a toolkit of promoter::YFPN lines reporting jasmonic acid (JA)-, salicylic acid (SA)-, ethylene (ET)- and reactive oxygen species (ROS)- dependent signalling. Finally, marker responses were analysed during invasion by the root pathogen Fusarium oxysporum. The DAMP AtPep1 triggered a stronger activation of the defence markers compared to flg22 and the chitin heptamer. In contrast to the tested MAMPs, AtPep1 induced SA- and JA-signalling markers in the root and caused a severe inhibition of root growth. Fungal attack resulted in a strong activation of defence genes in tissues close to the invading fungal hyphae. The results collectively suggest that AtPep1 presents a stronger danger signal to the Arabidopsis root than the MAMPs flg22 and chitin heptamer.

  2. Transmission electron microscopy studying of structural features of NiTi B2 phase formed under pulsed electron-beam impact

    Energy Technology Data Exchange (ETDEWEB)

    Meisner, Ludmila L.; Semin, Viktor O.; Gudimova, Ekaterina Y. [Institute of Strength Physicists and Materials Science SB RAS, Tomsk, 634055 (Russian Federation); National Research Tomsk State University, Tomsk, 634050 (Russian Federation); Neiman, Alexey A., E-mail: nasa@ispms.tsc.ru; Lotkov, Alexander I.; Ostapenko, Marina G. [Institute of Strength Physicists and Materials Science SB RAS, Tomsk, 634055 (Russian Federation); Koval, Nikolai N.; Teresov, Anton D. [National Research Tomsk State University, Tomsk, 634050 (Russian Federation); Institute of High Current Electronics SB RAS, Tomsk, 634055 (Russian Federation)

    2015-10-27

    By transmission electron microscopy method the evolution of structural-phase states on a depth of close to equiatomic NiTi modified layer has been studied. Modification performed by pulse impact on its surface low-energy high-current electron beam (beam energy density 10 J/sm{sup 2}, 10 pulses, pulse duration 50mks). It is established that during the treatment in the layer thickness of 8–10 μm, the melting of primary B2 phase and contained therein as Ti2Ni phase particles occurs. The result is change in the concentration ratio of titanium and nickel in the direction of increasing titanium content, which was confirmed by X-ray analysis in the form of increased unit cell parameter B2 phase. Analysis of the electron diffraction pattern showed that the modified layer is characterized as a highly distorted structure on the basis of bcc lattice. Lattice distortions are maximal near the surface and extends to a depth of melt. In subjacent layer there is gradual decline lattice distortions is observed.

  3. Genital impacts Genital impacts

    Directory of Open Access Journals (Sweden)

    Luiz Felipe G Soares

    2008-04-01

    Full Text Available I propose to analyze three images of genitalia from three different films that do not have sex as their central subject: (1 Lígia’s (Leona Cavalli’s vulva in Claudio Assis’s Amarelo Manga (Brazil, 2002, (2 Stoffer’s (Jens Albinus’s erect penis in Lars von Trier’s The Idiots (Denmark, 1998, and (3 transsexual Dil’s (Jaye Davidson’s penis in Neil Jordan’s The Crying Game (USA, 1992. All three images are explicit and surprising enough to provoke impact, both in diegetic and extra-diagetic spaces. intend to compare the three images and investigate the nature of their impacts, not directly in terms of morality, but in their relation with two theoretical assumptions: (1 the intense way in which, according to Linda Nicholson (1999, so many cultures insist in interpreting bodies and genitalia as still capable of defining gender characters, and (2 the notion of image, not as representation, but as image itself, as “what it is”, or as “the place of every transformation in the universe”, as suggested first by Bergson (2005, and then by Deleuze (1983-5, Rancière (2001 and Agamben (1995. The Deleuzean retard may indicate the way in which genitalia, as image, turn into enigma, in the very passage from nature to culture. The three shots give back to those clear images of genitalia the property they have always had: their character of central pieces in the game of such passage. The contrast between such simple and clear images and all those complex games corresponds to the nature of the impact I want to investigate. film; genitalia; narrative. I propose to analyze three images of genitalia from three different films that do not have sex as their central subject: (1 Lígia’s (Leona Cavalli’s vulva in Claudio Assis’s Amarelo Manga (Brazil, 2002, (2 Stoffer’s (Jens Albinus’s erect penis in Lars von Trier’s The Idiots (Denmark, 1998, and (3 transsexual Dil’s (Jaye Davidson’s penis in Neil Jordan’s The Crying Game (USA

  4. [The impact of parental divorce on the relationships of young adults].

    Science.gov (United States)

    De Graaf, A

    1996-08-01

    "The 1993 Netherlands Fertility and Family Survey shows that parental divorce has an impact on (the attitudes towards) relationships of young adults. Children of divorced parents leave home at an earlier age and have a stronger preference for cohabitation. Once a relationship (cohabitation or marriage) has started, it is more likely to end in separation or divorce." (SUMMARY IN ENG) excerpt

  5. Impact of bank competition on the interest rate pass-through in the euro area

    NARCIS (Netherlands)

    van Leuvensteijn, M.; Kok Sørensen, C.; Bikker, J.A.; van Rixtel, A.A.R.J.M.

    This paper analyses the impact of loan market competition on the interest rates applied by euro area banks to loans and deposits during the 1994-2004 period, using a novel measure of competition called the Boone indicator. We find evidence that stronger competition implies significantly lower

  6. A novel chimeric Hepatitis B virus S/preS1 antigen produced in mammalian and plant cells elicits stronger humoral and cellular immune response than the standard vaccine-constituent, S protein.

    Science.gov (United States)

    Dobrica, Mihaela-Olivia; Lazar, Catalin; Paruch, Lisa; Skomedal, Hanne; Steen, Hege; Haugslien, Sissel; Tucureanu, Catalin; Caras, Iuliana; Onu, Adrian; Ciulean, Sonya; Branzan, Alexandru; Clarke, Jihong Liu; Stavaru, Crina; Branza-Nichita, Norica

    2017-08-01

    Chronic Hepatitis B Virus (HBV) infection leads to severe liver pathogenesis associated with significant morbidity and mortality. As no curable medication is yet available, vaccination remains the most cost-effective approach to limit HBV spreading and control the infection. Although safe and efficient, the standard vaccine based on production of the small (S) envelope protein in yeast fails to elicit an effective immune response in about 10% of vaccinated individuals, which are at risk of infection. One strategy to address this issue is the development of more immunogenic antigens. Here we describe a novel HBV antigen obtained by combining relevant immunogenic determinants of S and large (L) envelope proteins. Our approach was based on the insertion of residues 21-47 of the preS1 domain of the L protein (nomenclature according to genotype D), involved in virus attachment to hepatocytes, within the external antigenic loop of S. The resulting S/preS1 21-47 chimera was successfully produced in HEK293T and Nicotiana benthamiana plants, as a more economical recombinant protein production platform. Comparative biochemical, functional and electron microscopy analysis indicated assembly of the novel antigen into subviral particles in mammalian and plant cells. Importantly, these particles preserve both S- and preS1-specific epitopes and elicit significantly stronger humoral and cellular immune responses than the S protein, in both expression systems used. Our data promote this antigen as a promising vaccine candidate to overcome poor responsiveness to the conventional, S protein-based, HBV vaccine. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Impact cratering

    Indian Academy of Sciences (India)

    In addition, further improvement of our understanding of the physico–chemical and geological processes fundamental to the impact cratering process is required for reliable numerical modeling of the process, and also for the correlation of impact magnitude and environmental effects. Over the last few decades, impact ...

  8. Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

    Science.gov (United States)

    Swathi A. Turlapati; Rakesh Minocha; Stephanie Long; Jordan Ramsdell; Subhash C. Minocha

    2015-01-01

    The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham, MA, USA. Thirty soil samples (3 treatments × 2 soil horizons × 5 subplots) were collected in 2009 from untreated (control), low nitrogen-amended (LN; 50 kg NH4NO3ha-1yr

  9. Scenarios and Technological Challenges for a LHC Luminosity Upgrade: Introduction to the LHC Upgrade Program and Summary of Physics Motivations (1/5)

    CERN Multimedia

    CERN. Geneva; Michelangelo Mangano

    2009-01-01

    After a general introduction to the motivations for a LHC upgrade, the lectures will discuss the beam dynamics and technological challenges of the increase of the LHC luminosity, and the possible scenarios. Items such as a stronger final focus with larger aperture magnets, crab cavities, electron cloud issues, beam-beam interaction, machine protection and collimation will be discussed.

  10. Local Residential Segregation Matters: Stronger Association of Census Tract Compared to Conventional City-Level Measures with Fatal and Non-Fatal Assaults (Total and Firearm Related), Using the Index of Concentration at the Extremes (ICE) for Racial, Economic, and Racialized Economic Segregation, Massachusetts (US), 1995-2010.

    Science.gov (United States)

    Krieger, Nancy; Feldman, Justin M; Waterman, Pamela D; Chen, Jarvis T; Coull, Brent A; Hemenway, David

    2017-04-01

    Research on residential segregation and health, primarily conducted in the USA, has chiefly employed city or regional measures of racial segregation. To test our hypothesis that stronger associations would be observed using local measures, especially for racialized economic segregation, we analyzed risk of fatal and non-fatal assault in Massachusetts (1995-2010), since this outcome is strongly associated with residential segregation. The segregation metrics comprised the Index of Concentration at the Extremes (ICE), the Index of Dissimilarity, and poverty rate, with measures computed at both the census tract and city/town level. Key results were that larger associations between fatal and non-fatal assaults and residential segregation occurred for models using the census tract vs. city/town measures, with the greatest associations observed for racialized economic segregation. For fatal assaults, comparing the bottom vs. top quintiles, the incidence rate ratio (and 95% confidence interval (CI)) in models using the census tract measures equaled 3.96 (95% CI 3.10, 5.06) for the ICE for racialized economic segregation, 3.26 (95% CI 2.58, 4.14) for the ICE for income, 3.14 (95% CI 2.47, 3.99) for poverty, 2.90 (95% CI 2.21, 3.81) for the ICE for race/ethnicity, and only 0.93 (95% CI 0.79, 1.11) for the Index of Dissimilarity; in models that included both census tract and city/town ICE measures, this risk ratio for the ICE for racialized economic segregation was higher at the census tract (3.29; 95% CI 2.43, 4.46) vs. city/town level (1.61; 95% CI 1.12, 2.32). These results suggest that, at least in the case of fatal and non-fatal assaults, research on residential segregation should employ local measures, including of racialized economic segregation, to avoid underestimating the adverse impact of segregation on health.

  11. Impacting Society through Astronomy Undergraduate Courses

    Science.gov (United States)

    Schleigh, Sharon

    2015-04-01

    A high percentage of non-science majors enroll in undergraduate, introductory astronomy courses across the country. The perception of the astronomy course as being easier than the ``hard sciences'' and the idea that the course will focus on ``pretty pictures'', influences the interests of the non-science majors. Often the students that enroll in these courses will not take other science courses, resulting in the only opportunity to teach college students about basic scientific concepts that impact their lives. Vast misconceptions about the nature of science, the role of science and scientists in society, and social issues embedded in scientific information, impact the decisions that individuals make about every day events. In turn, these decisions influence the policies that construct our society. This talk will provide an overview of the common misconceptions and discuss how they impact our society as a whole. The research presented provides evidence of the impact that introductory college astronomy courses have on changing these everyday misconceptions and influencing non-science majors' ideas about science in society. The research suggests that introductory courses designed for non-science majors are extremely important in impacting our society, and begs for a stronger understanding and implementation of best practices for teaching and learning in the college classroom environment.

  12. Health Impacts of the Great Recession: A Critical Review.

    Science.gov (United States)

    Margerison-Zilko, Claire; Goldman-Mellor, Sidra; Falconi, April; Downing, Janelle

    2016-03-01

    The severity, sudden onset, and multipronged nature of the Great Recession (2007-2009) provided a unique opportunity to examine the health impacts of macroeconomic downturn. We comprehensively review empirical literature examining the relationship between the Recession and mental and physical health outcomes in developed nations. Overall, studies reported detrimental impacts of the Recession on health, particularly mental health. Macro- and individual-level employment- and housing-related sequelae of the Recession were associated with declining fertility and self-rated health, and increasing morbidity, psychological distress, and suicide, although traffic fatalities and population-level alcohol consumption declined. Health impacts were stronger among men and racial/ethnic minorities. Importantly, strong social safety nets in some European countries appear to have buffered those populations from negative health effects. This literature, however, still faces multiple methodological challenges, and more time may be needed to observe the Recession's full health impact. We conclude with suggestions for future work in this field.

  13. Article Impact Means Journal Impact

    OpenAIRE

    Reips, Ulf-Dietrich; Matzat, Uwe

    2013-01-01

    These days there is a lot of misunderstanding of scientometrics and we often see a confusion of the research with its indicators. Science ministries and university administrators try to push their country's or institution's "research impact" by telling researchers to increase numeric figures that were invented as proxies for later assessment. In obvious juxtaposition to common sense this even leads to direct orders to postdocs "to only publish in high impact journals" and not to engage in oth...

  14. The Impact of Sustainable Development Technology on a Small Economy—The Case of Energy-Saving Technology

    Directory of Open Access Journals (Sweden)

    Xiding Chen

    2018-02-01

    Full Text Available We investigated the impact of a sustainable development technology on the macroeconomic variables in a small economy utilizing a case study with a stochastically improving energy saving technology and a stochastically increasing energy price. The results show the technological displacement effects of energy saving technology are stronger, but there are more ambiguous instantaneous returns to physical capital. However, the energy saving technology’s displacement effects might not affect the conditions under which the Harberger-Laursen-Metzler (HLM effect holds. The effects of rising energy prices on bonds are stronger, and there are more ambiguous instantaneous returns, but the conditions under which the HLM effect holds are different.

  15. The impacts of different expansion modes on performance of small solar energy firms: perspectives of absorptive capacity.

    Science.gov (United States)

    Chen, Hsing Hung; Shen, Tao; Xu, Xin-Long; Ma, Chao

    2013-01-01

    The characteristics of firm's expansion by differentiated products and diversified products are quite different. However, the study employing absorptive capacity to examine the impacts of different modes of expansion on performance of small solar energy firms has never been discussed before. Then, a conceptual model to analyze the tension between strategies and corporate performance is proposed to filling the vacancy. After practical investigation, the results show that stronger organizational institutions help small solar energy firms expanded by differentiated products increase consistency between strategies and corporate performance; oppositely, stronger working attitudes with weak management controls help small solar energy firms expanded by diversified products reduce variance between strategies and corporate performance.

  16. The Impact of Sustainable Development Technology on a Small Economy—The Case of Energy-Saving Technology

    Science.gov (United States)

    Huang, Qinghua; Huang, Weilun; Li, Xue

    2018-01-01

    We investigated the impact of a sustainable development technology on the macroeconomic variables in a small economy utilizing a case study with a stochastically improving energy saving technology and a stochastically increasing energy price. The results show the technological displacement effects of energy saving technology are stronger, but there are more ambiguous instantaneous returns to physical capital. However, the energy saving technology’s displacement effects might not affect the conditions under which the Harberger-Laursen-Metzler (HLM) effect holds. The effects of rising energy prices on bonds are stronger, and there are more ambiguous instantaneous returns, but the conditions under which the HLM effect holds are different. PMID:29419788

  17. The Impact of Sustainable Development Technology on a Small Economy-The Case of Energy-Saving Technology.

    Science.gov (United States)

    Chen, Xiding; Huang, Qinghua; Huang, Weilun; Li, Xue

    2018-02-08

    We investigated the impact of a sustainable development technology on the macroeconomic variables in a small economy utilizing a case study with a stochastically improving energy saving technology and a stochastically increasing energy price. The results show the technological displacement effects of energy saving technology are stronger, but there are more ambiguous instantaneous returns to physical capital. However, the energy saving technology's displacement effects might not affect the conditions under which the Harberger-Laursen-Metzler (HLM) effect holds. The effects of rising energy prices on bonds are stronger, and there are more ambiguous instantaneous returns, but the conditions under which the HLM effect holds are different.

  18. Economic impact

    Energy Technology Data Exchange (ETDEWEB)

    Technology Transfer Department

    2001-06-01

    In federal fiscal year 2000 (FY00), Berkeley Lab had 4,347 full- and part-time employees. In addition, at any given time of the year, there were more than 1,000 Laboratory guests. These guests, who also reside locally, have an important economic impact on the nine-county Bay Area. However, Berkeley Lab's total economic impact transcends the direct effects of payroll and purchasing. The direct dollars paid to the Lab's employees in the form of wages, salaries, and benefits, and payments made to contractors for goods and services, are respent by employees and contractors again and again in the local and greater economy. Further, while Berkeley Lab has a strong reputation for basic scientific research, many of the Lab's scientific discoveries and inventions have had direct application in industry, spawning new businesses and creating new opportunities for existing firms. This analysis updates the Economic Impact Analysis done in 1996, and its purpose is to describe the economic and geographic impact of Laboratory expenditures and to provide a qualitative understanding of how Berkeley Lab impacts and supports the local community. It is intended as a guide for state, local, and national policy makers as well as local community members. Unless otherwise noted, this analysis uses data from FY00, the most recent year for which full data are available.

  19. The Incredible Shrinking Iguana: Impact of Galapagos

    Science.gov (United States)

    Murtugudde, R.; Karnauskas, K.

    2007-05-01

    Galapagos Islands are well known for Darwin's epiphany about evolution after his 'discovery' of the islands. The incredible transformation that the key species on this island undergo on ENSO time-scales is recorded extensively. The impact of Galapagos on SSTs and ocean primary production has been conjectured but some recent work demonstrates that their influence extdends thousands of kilometers via stronger TIWs and modulations of the termination of EUC and related air-sea interactions. Tropical Pacific is not only the theater of action for ENSO dynamics but the ecosystem is the most studied iron limited region due to its HNLC characteristics. This study addresses the physical and biogeochemical impacts of the Galapagos islands with a OGCM-biogeochemical model coupled to a simple wind-anomaliy model. The impact of Galapagos is to warm the cold-tongue by upto 1C with a major impact on the termination of the EUC that results in large-scale circulation changes that extend to the South American coast as far south as 20S. If the islands are not included, then the equatorial Kelvin waves extend their impact on thermocline variability all the way to the eastern boundary and lead to a quasi-biennial ENSO whereas the impact of Galapagos islands shifts the frequency to a quasi- quadrennial time-scale. The impacts on the ecosystem are commensurate with the seasonal and interannual variability changes with the addition of dissolved iron supply related to EUC changes. Bio-physical feedbacks in the deep tropical Pacific also tend to warm SSTs and the impact of Galapagos is thus to flatten the east-west SST gradient resulting in less-frequent and weaker ENSO events. The relevance of these results to longer time-scale variability and any potential analogs to global warming and sea level change are discussed in detail.

  20. Effectiveness of Health Impact Assessments: A Synthesis of Data From Five Impact Evaluation Reports.

    Science.gov (United States)

    Dannenberg, Andrew L

    2016-06-30

    Since the 1990s, the use of health impact assessments (HIAs) has grown for considering the potential health impacts of proposed policies, plans, programs, and projects in various sectors. Evaluation of HIA impacts is needed for understanding the value of HIAs, improving the methods involved in HIAs, and potentially expanding their application. Impact evaluations examine whether HIAs affect decisions and lead to other effects. I reviewed HIA impact evaluations identified by literature review and professional networking. I abstracted and synthesized data on key findings, success factors, and challenges from 5 large evaluations conducted in the United States, Europe, Australia, and New Zealand and published from 2006 through 2015. These studies analyzed impacts of approximately 200 individual HIAs. Major impacts of HIAs were directly influencing some decisions, improving collaboration among stakeholders, increasing awareness of health issues among decision makers, and giving community members a stronger voice in local decisions. Factors that contributed to successful HIAs included engaging stakeholders, timeliness, policy and systems support for conducting HIAs, having people with appropriate skills on the HIA team, obtaining the support of decision makers, and providing clearly articulated, feasible recommendations. Challenges that may have reduced HIA success were poor timeliness, underestimation of time and resources needed, difficulty in accessing relevant data, use of jargon in HIA reports, difficulty in involving decision makers in the HIA process, and absence of a requirement to conduct HIAs. HIAs can be useful to promote health and mitigate adverse impacts of decisions made outside of the health sector. Stakeholder interactions and community engagement may be as important as direct impacts of HIAs. Multiple factors are required for HIA success. Further work could strengthen the role of HIAs in promoting equity, examine HIA impacts in specific sectors, and

  1. Impacts of climate extremes on activity sectors stakeholders' perspective

    Science.gov (United States)

    Kundzewicz, Z. W.; Giannakopoulos, C.; Schwarb, M.; Stjernquist, I.; Schlyter, P.; Szwed, M.; Palutikof, J.

    2008-06-01

    Significant changes in the climatic system have been observed, which may be attributed to human-enhanced greenhouse effect. Even stronger changes are projected for the future, impacting in an increasing way on human activity sectors. The present contribution, prepared in the framework of the MICE (Modelling the Impact of Climate Extremes) Project of the European Union, reviews how climate change may impact on winter tourism in the Alpine region, intense precipitation and flood potential in central Europe, forest damage in Scandinavia and beach holidays in the Mediterranean coast. Impacts are likely to be serious and largely adverse. Due to a lack of adequate information and lack of broadly accepted and reliable mathematical models describing the impact of changes in climate extremes on these activity sectors, it has been found useful to use expert judgement based impact assessment. Accordingly, regional mini-workshops were organized serving as platforms for communication between scientists and stakeholders, vehicles for dissemination of the state-of-the-art of the scientific understanding and for learning stakeholders’ view on extreme events, their impacts and the preparedness system. Stakeholders had the opportunity to react to the scientific results and to reflect on their perception of the likely impacts of projected changes in extremes on relevant activity sectors and the potential to adapt and avert adverse consequences. The results reported in this paper present the stakeholders’ suggestions for essential information on different extreme event impacts and their needs from science.

  2. Impact of Advertising Appeals on Purchase Intention

    Directory of Open Access Journals (Sweden)

    Predrag Jovanović

    2016-04-01

    Full Text Available Companies use various appeals in their advertising practice to impact consumers’ attitudes and purchase intention by an advertisement. Advertising appeals can be divided into rational or emotional, depending on whether companies want to influence the rational or the emotional motives of the consumer to purchase of the advertised product. Since there is no general pattern for the use of appeals and the success of an advertising message, this study aims to explore the impact of the emotional and rational advertising appeals on the purchase intention. The results of the empirical research, conducted using the focus groups method, are shown in this paper and the focus group participants were members of the student population.The research results indicate that different advertising appeals may have a different impact on the consumer’s purchase intention; in case of women, the emotional appeal has a stronger impact while for men it is the rational appeal, while “fear appeal” proved to be effective to a certain point, after which it causes selective perception and rejection. This implies that depending on the product, its purpose and target group, advertisers can choose the type of appeal, combination of the appeals and their creative presentation, based on the empirical confirmation of the efficiency the approach.

  3. Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

    Directory of Open Access Journals (Sweden)

    Swathi Anuradha Turlapati

    2015-02-01

    Full Text Available The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham MA. Thirty soil samples (3 treatments x 2 soil horizons x 5 subplots were collected in 2009 from untreated (control, low nitrogen-amended (LN; 50 kg NH4NO3 ha-1 yr-1 and high nitrogen-amended (HN; 150 kg NH4NO3 ha-1 yr-1 plots. PCR-amplified partial 16S rDNA sequences made from soil DNA were subjected to pyrosequencing (Turlapati et al., 2013 and analyses using oligotyping. The parameters M (the minimum count of the most abundant unique sequence in an oligotype and s (minimum number of samples in which an oligotype is expected to be present had to be optimized for forest soils because of high diversity and the presence of rare organisms. Comparative analyses of the pyrosequencing data by oligotyping and OTU (Operational Taxonomic Unit clustering tools indicated that the former yields more refined units of taxonomy with sequence similarity of ≥99.5%. Sequences affiliated with 4 new phyla and 73 genera were identified in the present study as compared to 27 genera reported earlier from the same data (Turlapati et al., 2013. Significant rearrangements in the bacterial community structure were observed with N-amendments revealing the presence of additional genera in N-amended plots with the absence of some that were present in the control plots. Permutational MANOVA analyses indicated significant variation associated with soil horizon and N treatment for a majority of the phyla. In most cases soil horizon partitioned more variation relative to treatment and treatment effects were more evident for the organic horizon. Mantel test results for organic soil showed significant positive correlations between bacterial communities and most soil parameters including NH4 and NO3. In mineral soil, correlations were seen only with pH, NH4 and NO3. Regardless of the pipeline used, a major hindrance for such a study remains to be the lack of reference

  4. The impact of parental attachment and feelings of isolation on adolescent fear of crime at school.

    Science.gov (United States)

    Wallace, Lisa Hutchinson; May, David C

    2005-01-01

    While scores of researchers have examined the antecedents of fear of criminal victimization among adults, research examining the correlates of such fear among adolescents, particularly in the school setting, is limited. Using data from 2136 public school students from a rural Southern state, we examine the association between fear of criminal victimization and race, gender, age, attachment to parents, feelings of isolation, and victimization. We determine that adolescents who have been victimized by crime are far more fearful than their counterparts who have not. Additionally, we determine that youth who have lower levels of attachment to parents and higher levels of isolation/alienation are also more fearful of criminal victimization than their counterparts. Interestingly, the impact of isolation on fear of criminal victimization is stronger for whites than nonwhites while the impact of parental attachment is stronger for males than females. Implications for policy and future research are also discussed.

  5. Wildlife - watching tourism of Romania and its impact on species and habitats.

    OpenAIRE

    George Bouros

    2012-01-01

    Wildlife - watching tourism from Romania starts to become more popular among foreign tourists, who want to see the large carnivores from Carpathians or the rare birds of the Danube Delta. The high biodiversity and the untouched habitats from these "sensitive" areas, makes the impact of the tourism to be more stronger, so it is required a sustainable management of this type of ecoturism. In order to have a healthy management of this tourism type, it is necessary to understand the behavior of s...

  6. Spittlebug impacts on sugarcane quality and ethanol production

    Directory of Open Access Journals (Sweden)

    Gisele Cristina Ravaneli

    2011-02-01

    Full Text Available The objective of this work was to evaluate the impacts of spittlebug (Mahanarva fimbriolata attack on sugarcane quality and ethanol production. Technological and microbiological parameters of juice and fermentation process were evaluated in ten fermentation cycles and two harvest seasons. Treatments consisted of different spittlebug stalk damage levels: control, with 100% of apparently healthy stalks; medium, with 15% of damaged or dry stalks (DDS; high, with 30% of DDS; and very high, with 60% of DDS. Spittlebug attack caused significant losses in cane quality, reducing total soluble solids, sucrose content, total reducing sugars, and pH, and increasing total phenolic compounds, and total and volatile juice acidity. The fermentation process was also significantly affected, resulting in lower ethanol content in wine. There was an increase in acetaldehyde concentration in the distillate. The spittlebug attack caused negative impacts on sugarcane quality and fermentation process, and these impacts are stronger in late season harvests.

  7. Triple Impact

    Science.gov (United States)

    2005-01-01

    24 July 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a 1.5 meters per pixel (5 ft/pixel) view of three aligned meteor impact craters on the floor of a much larger crater in the Noachis Terra region. The craters may have formed together from a single event in which the impactor (the meteor) was broken into three pieces. Location near: 33.9oS, 10.5oW Image width: width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Spring

  8. Impact Crater

    Science.gov (United States)

    2006-01-01

    16 January 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows an impact crater, roughly the size of the famous Meteor Crater in northern Arizona, U.S.A., in western Elysium Planitia. Light-toned, windblown ripples of sediment have accumulated in subtle troughs and in the lee -- the downwind side -- of the crater. Location near: 28.4oN, 247.9oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  9. Measuring the impact of allied health research

    Directory of Open Access Journals (Sweden)

    Heath J

    2011-06-01

    Full Text Available Jan Heath, Karen Grimmer-Somers, Steve Milanese, Susan Hillier, Ellena King, Kylie Johnston, Kylie Wall, Olivia Thorpe, Alexandra Young, Saravana KumarSchool of Health Sciences, University of South Australia, Adelaide, SA, AustraliaBackground: Excellence in Research for Australia (ERA rankings are given to academic journals in which Australian academics publish. This provides a metric on which Australian institutions and disciplines are ranked for international competitiveness. This paper explores the issues surrounding the ERA rankings of allied health journals in Australia.Methods: We conducted a broad search to establish a representative list of general allied health and discipline-specific journals for common allied health disciplines. We identified the ERA rankings and impact factors for each journal and tested the congruence between these metrics within the disciplines.Results: Few allied health journals have high ERA rankings (A*/A, and there is variability in the impact factors assigned to journals within the same ERA rank. There is a small group of allied health researchers worldwide, and this group is even smaller when divided by discipline. Current publication metrics may not adequately assess the impact of research, which is largely aimed at clinicians to improve clinical practice. Moreover, many journals are produced by underfunded professional associations, and readership is often constrained by small numbers of clinicians in specific allied health disciplines who are association members.Conclusion: Allied health must have a stronger united voice in the next round of ERA rankings. The clinical impact of allied health journals also needs to be better understood and promoted as a research metric.Keywords: allied health, research impact, publication metrics

  10. Impact of stock market structure on intertrade time and price dynamics.

    Science.gov (United States)

    Ivanov, Plamen Ch; Yuen, Ainslie; Perakakis, Pandelis

    2014-01-01

    We analyse times between consecutive transactions for a diverse group of stocks registered on the NYSE and NASDAQ markets, and we relate the dynamical properties of the intertrade times with those of the corresponding price fluctuations. We report that market structure strongly impacts the scale-invariant temporal organisation in the transaction timing of stocks, which we have observed to have long-range power-law correlations. Specifically, we find that, compared to NYSE stocks, stocks registered on the NASDAQ exhibit significantly stronger correlations in their transaction timing on scales within a trading day. Further, we find that companies that transfer from the NASDAQ to the NYSE show a reduction in the correlation strength of transaction timing on scales within a trading day, indicating influences of market structure. We also report a persistent decrease in correlation strength of intertrade times with increasing average intertrade time and with corresponding decrease in companies' market capitalization-a trend which is less pronounced for NASDAQ stocks. Surprisingly, we observe that stronger power-law correlations in intertrade times are coupled with stronger power-law correlations in absolute price returns and higher price volatility, suggesting a strong link between the dynamical properties of intertrade times and the corresponding price fluctuations over a broad range of time scales. Comparing the NYSE and NASDAQ markets, we demonstrate that the stronger correlations we find in intertrade times for NASDAQ stocks are associated with stronger correlations in absolute price returns and with higher volatility, suggesting that market structure may affect price behavior through information contained in transaction timing. These findings do not support the hypothesis of universal scaling behavior in stock dynamics that is independent of company characteristics and stock market structure. Further, our results have implications for utilising transaction timing

  11. Impact of Stock Market Structure on Intertrade Time and Price Dynamics

    Science.gov (United States)

    Ivanov, Plamen Ch.; Yuen, Ainslie; Perakakis, Pandelis

    2014-01-01

    We analyse times between consecutive transactions for a diverse group of stocks registered on the NYSE and NASDAQ markets, and we relate the dynamical properties of the intertrade times with those of the corresponding price fluctuations. We report that market structure strongly impacts the scale-invariant temporal organisation in the transaction timing of stocks, which we have observed to have long-range power-law correlations. Specifically, we find that, compared to NYSE stocks, stocks registered on the NASDAQ exhibit significantly stronger correlations in their transaction timing on scales within a trading day. Further, we find that companies that transfer from the NASDAQ to the NYSE show a reduction in the correlation strength of transaction timing on scales within a trading day, indicating influences of market structure. We also report a persistent decrease in correlation strength of intertrade times with increasing average intertrade time and with corresponding decrease in companies' market capitalization–a trend which is less pronounced for NASDAQ stocks. Surprisingly, we observe that stronger power-law correlations in intertrade times are coupled with stronger power-law correlations in absolute price returns and higher price volatility, suggesting a strong link between the dynamical properties of intertrade times and the corresponding price fluctuations over a broad range of time scales. Comparing the NYSE and NASDAQ markets, we demonstrate that the stronger correlations we find in intertrade times for NASDAQ stocks are associated with stronger correlations in absolute price returns and with higher volatility, suggesting that market structure may affect price behavior through information contained in transaction timing. These findings do not support the hypothesis of universal scaling behavior in stock dynamics that is independent of company characteristics and stock market structure. Further, our results have implications for utilising transaction timing

  12. Impact of stock market structure on intertrade time and price dynamics.

    Directory of Open Access Journals (Sweden)

    Plamen Ch Ivanov

    Full Text Available We analyse times between consecutive transactions for a diverse group of stocks registered on the NYSE and NASDAQ markets, and we relate the dynamical properties of the intertrade times with those of the corresponding price fluctuations. We report that market structure strongly impacts the scale-invariant temporal organisation in the transaction timing of stocks, which we have observed to have long-range power-law correlations. Specifically, we find that, compared to NYSE stocks, stocks registered on the NASDAQ exhibit significantly stronger correlations in their transaction timing on scales within a trading day. Further, we find that companies that transfer from the NASDAQ to the NYSE show a reduction in the correlation strength of transaction timing on scales within a trading day, indicating influences of market structure. We also report a persistent decrease in correlation strength of intertrade times with increasing average intertrade time and with corresponding decrease in companies' market capitalization-a trend which is less pronounced for NASDAQ stocks. Surprisingly, we observe that stronger power-law correlations in intertrade times are coupled with stronger power-law correlations in absolute price returns and higher price volatility, suggesting a strong link between the dynamical properties of intertrade times and the corresponding price fluctuations over a broad range of time scales. Comparing the NYSE and NASDAQ markets, we demonstrate that the stronger correlations we find in intertrade times for NASDAQ stocks are associated with stronger correlations in absolute price returns and with higher volatility, suggesting that market structure may affect price behavior through information contained in transaction timing. These findings do not support the hypothesis of universal scaling behavior in stock dynamics that is independent of company characteristics and stock market structure. Further, our results have implications for utilising

  13. Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.

    Science.gov (United States)

    Farré, Daniel; Muñoz, Ana; Moreno, Estefanía; Reyes-Resina, Irene; Canet-Pons, Júlia; Dopeso-Reyes, Iria G; Rico, Alberto J; Lluís, Carme; Mallol, Josefa; Navarro, Gemma; Canela, Enric I; Cortés, Antonio; Labandeira-García, José L; Casadó, Vicent; Lanciego, José L; Franco, Rafael

    2015-12-01

    Radioligand binding assays to rat striatal dopamine D1 receptors showed that brain lateralization of the dopaminergic system were not due to changes in expression but in agonist affinity. D1 receptor-mediated striatal imbalance resulted from a significantly higher agonist affinity in the left striatum. D1 receptors heteromerize with dopamine D3 receptors, which are considered therapeutic targets for dyskinesia in parkinsonian patients. Expression of both D3 and D1-D3 receptor heteromers were increased in samples from 6-hydroxy-dopamine-hemilesioned rats rendered dyskinetic by treatment with 3, 4-dihydroxyphenyl-L-alanine (L-DOPA). Similar findings were obtained using striatal samples from primates. Radioligand binding studies in the presence of a D3 agonist led in dyskinetic, but not in lesioned or L-DOPA-treated rats, to a higher dopamine sensitivity. Upon D3-receptor activation, the affinity of agonists for binding to the right striatal D1 receptor increased. Excess dopamine coming from L-DOPA medication likely activates D3 receptors thus making right and left striatal D1 receptors equally responsive to dopamine. These results show that dyskinesia occurs concurrently with a right/left striatal balance in D1 receptor-mediated neurotransmission.

  14. Reduce Fraud Risk in Your District with Stronger Internal Controls

    Science.gov (United States)

    Okrzesik, Daryl J.; Nuehring, Bert G.

    2011-01-01

    Internal accounts offer schools a faster, more convenient way to handle the income and expenses that result from student fees, school clubs and organizations, field trips, fund-raising, and similar activities. But this convenience also incurs the added risk of fraud. Fortunately, there are proven ways to strengthen internal controls and reduce…

  15. Women's political participation leads to stronger local economies ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-08

    Jun 8, 2016 ... Changes in key laws, such as the Hindu Succession Act, have benefited Hindu women by providing them with access to assets, such as property rights. This has increased their potential to participate in the decision-making process, and encouraged them to participate in the local economy. Reforms have ...

  16. Stronger Collaborations Needed for Successful Space Weather Research

    Science.gov (United States)

    Akasofu, Syun-Ichi

    2007-12-01

    One of the purposes of space weather research is to predict when and how the electromagnetic environment around the Earth will be disturbed after specific (solar storms,) which are defined here as various transient solar phenomena that occur at the time of solar flares [Akasofu and Chapman, 1972]. Accurate space weather predictions require an integrating and synthesizing research effort by a close collaboration among solar physicists, interplanetary physicists, magnetospheric physicists, and upper atmosphere physicists. Unfortunately, such integration/synthesis (I/S) projects in the past have often become an umbrella under which individual researchers in the four disciplines pursue only subjects of their own interests, disintegrate into individual projects, and even encourage the trend of infinite specialization because of the potential availability of additional funds.

  17. CIOs Talk about Budgets: Emerging Stronger and Leaner

    Science.gov (United States)

    Maas, Bruce; Miller, Fredrick; Orr, Pattie; Ouska, Julie; Waggener, Shelton M.; Goldstein, Philip J., Comp.

    2009-01-01

    To explore current and future implications of the economic downturn, "EDUCAUSE Review" assembled a panel of senior IT leaders: (1) Bruce Maas, CIO, University of Wisconsin-Milwaukee; (2) Fredrick Miller, CIO, Furman University; (3) Pattie Orr, Vice President for IT and Dean of University Libraries, Baylor University; (4) Julie Ouska, CIO…

  18. Stronger at Depth: Jamming Grippers as Deep Sea Sampling Tools.

    Science.gov (United States)

    Licht, Stephen; Collins, Everett; Mendes, Manuel Lopes; Baxter, Christopher

    2017-12-01

    In this work we experimentally demonstrate (a) that the holding strength of universal jamming grippers increases as a function of the jamming pressure to greater than three atmospheres, and (b) that jamming grippers can be operated in the deep sea in ambient pressures exceeding one hundred atmospheres, where such high jamming pressures can be readily achieved. Laboratory experiments in a pressurized, water-filled test cell are used to measure the holding force of a "universal" style jamming gripper as a function of the pressure difference between internal membrane pressure and ambient pressure. Experiments at sea are used to demonstrate that jamming grippers can be installed on, and operated from, remotely operated vehicles at depths in excess of 1200 m. In both experiments, the jamming gripper consists of a latex balloon filled with a mixture of fresh water and ∼200 μm glass beads, which are cheaply available in large quantities as sand blasting media. The use of a liquid, rather than a gas, as the fluid media allows operation of the gripper with a closed-loop fluid system; jamming pressure is controlled with an electrically driven water hydraulic cylinder in the laboratory and with an oil hydraulic-driven large-bore water hydraulic cylinder at sea.

  19. Effective and Innovative Practices for Stronger Facilities Management.

    Science.gov (United States)

    Banick, Sarah

    2002-01-01

    Describes the five winners of the APPA's Effective & Innovative Practices Award. These facilities management programs and processes were recognized for enhancing service delivery, lowering costs, increasing productivity, improving customer service, generating revenue, or otherwise benefiting the educational institution. (EV)

  20. A three-legged stool needs a stronger third leg.

    Science.gov (United States)

    Greenberg, Ramon

    2013-12-01

    Whereas the target article stresses the neurobiology and psychology of dreams, this commentary emphasizes that the role of dreams in emotional integration and adaptation contributes to a fuller understanding of dreaming and memory. The dream presented in the target article is used, within the constraints of space, as a possible example of a broader approach to dream material.

  1. Does pattern-welding make Anglo-Saxon swords stronger?

    DEFF Research Database (Denmark)

    Birch, Thomas

    2013-01-01

    The purpose of pattern-welding, used for the construction of some Anglo-Saxon swords, has yet to be fully resolved. One suggestion is that the technique enhanced the mechanical properties of a blade. Another explanation is that pattern-welding created a desired aesthetic appearance. In order to a...

  2. Impacts of canonical and Modoki El Niño on tropical Atlantic SST

    Science.gov (United States)

    Amaya, Dillon J.; Foltz, Gregory R.

    2014-02-01

    The impacts of canonical and Modoki El Niño on tropical Atlantic sea surface temperature (SST) are quantified using composite analysis. Results show that El Niño Modoki fails to produce significant warming in the tropical Atlantic, in contrast to the well known warming following canonical El Niño events. El Niño Modoki instead induces significant cooling in the northeastern tropical Atlantic and near-neutral conditions elsewhere in the tropical Atlantic. It is shown that the difference in SST response stems primarily from a much stronger Pacific/North American (PNA) teleconnection pattern and stronger atmospheric Kelvin wave response during canonical events compared to Modoki. The stronger PNA pattern and Kelvin waves during canonical events generate anomalously weak surface winds in the tropical North Atlantic, driving anomalously weak evaporative cooling and warmer SSTs. Past research has shown significant decadal variability in the frequency of noncanonical El Niños relative to canonical events. If such variability continues, it is likely that the impact of El Niño on tropical Atlantic SST will also fluctuate from one decade to the next.

  3. Economical impact of orchiectomy for advanced prostate cancer

    Directory of Open Access Journals (Sweden)

    Paula Adriano A. P. de

    2003-01-01

    Full Text Available PURPOSE: To demonstrate the economical impact of surgical castration in comparison to the medical castration for patients with advanced prostate cancer. MATERIAL AND METHODS: Between January 2001 and December 2001, 32 patients with advanced prostate cancer underwent bilateral sub-capsular orchiectomy at our Hospital. The costs of this procedure were compared to the costs of medical castration with LH-RH analogues. RESULTS: The costs of the surgical procedure were extremely reduced when compared to published data on the medical treatment. Surgical castration did not have any stronger negative impact on the evolution of these patients when compared to medical castration. CONCLUSION: Surgical castration is an efficient and low cost treatment for advanced prostate cancer.

  4. Interpreting Dust Impact Signals Detected by the STEREO Spacecraft

    Science.gov (United States)

    O'Shea, E.; Sternovsky, Z.; Malaspina, D. M.

    2017-12-01

    There is no comprehensive understanding yet of how dust impacts on spacecraft (SC) generate signals detected by antenna instruments. The high sensitivity of the S/WAVES instrument and the large number and high diversity of dust impacts detected make the STEREO mission particularly well suited for a closer investigation. A floating perturbation model (FPP) was recently proposed to explain the characteristic shape of dust impact signals with an overshoot. The FPP model posits that the overshoot is due to the different discharge time constant of the SC and the individual antennas. Kinetic simulations are performed to demonstrate that, contrary to common belief, antennas are inefficient collectors of charged particles from impact plasmas. The collection efficiency is small, only 0.1-1%, varying weakly with the bias potential between the antenna and the SC, and more strongly with impact location. The low recollection efficiencies and an analysis of the shapes and scaling of typical and atypical signals recorded by S/WAVES suggest that, besides the mechanism described by the FPP model, there is another, possibly stronger mechanism that is responsible for generating the characteristic overshoot for most dust impact signals observed by STEREO.

  5. The Impacts of Different Expansion Modes on Performance of Small Solar Energy Firms: Perspectives of Absorptive Capacity

    OpenAIRE

    Chen, Hsing Hung; Shen, Tao; Xu, Xin-long; Ma, Chao

    2013-01-01

    The characteristics of firm’s expansion by differentiated products and diversified products are quite different. However, the study employing absorptive capacity to examine the impacts of different modes of expansion on performance of small solar energy firms has never been discussed before. Then, a conceptual model to analyze the tension between strategies and corporate performance is proposed to filling the vacancy. After practical investigation, the results show that stronger organizationa...

  6. Impacts of Boundary Conditions on the Simulation of Atmospheric Fields Using RegCM4 over CORDEX East Asia

    OpenAIRE

    Myoung Seok Suh; Seok Geun Oh

    2015-01-01

    The impacts of boundary conditions (BCs) on simulations of RegCM4 for mid-to-upper atmospheric fields over the CORDEX (COordinated Regional Downscaling EXperiment) East Asia domain were investigated using two datasets from integrations over 20 years (1989–2008) with two BCs (ERA and R2). The two datasets showed large differences for the atmospheric variables regardless of the geographic locations, heights, and seasons. The ERA dataset at 850 hPa displayed stronger northerly winds in the west...

  7. Potential impacts of nanotechnology on energy transmission applications and needs.

    Energy Technology Data Exchange (ETDEWEB)

    Elcock, D.; Environmental Science Division

    2007-11-30

    The application of nanotechnologies to energy transmission has the potential to significantly impact both the deployed transmission technologies and the need for additional development. This could be a factor in assessing environmental impacts of right-of-way (ROW) development and use. For example, some nanotechnology applications may produce materials (e.g., cables) that are much stronger per unit volume than existing materials, enabling reduced footprints for construction and maintenance of electricity transmission lines. Other applications, such as more efficient lighting, lighter-weight materials for vehicle construction, and smaller batteries having greater storage capacities may reduce the need for long-distance transport of energy, and possibly reduce the need for extensive future ROW development and many attendant environmental impacts. This report introduces the field of nanotechnology, describes some of the ways in which processes and products developed with or incorporating nanomaterials differ from traditional processes and products, and identifies some examples of how nanotechnology may be used to reduce potential ROW impacts. Potential environmental, safety, and health impacts are also discussed.

  8. Impacts of extension access and cooperative membership on technology adoption and household welfare.

    Science.gov (United States)

    Wossen, Tesfamicheal; Abdoulaye, Tahirou; Alene, Arega; Haile, Mekbib G; Feleke, Shiferaw; Olanrewaju, Adetunji; Manyong, Victor

    2017-08-01

    This paper examines the impacts of access to extension services and cooperative membership on technology adoption, asset ownership and poverty using household-level data from rural Nigeria. Using different matching techniques and endogenous switching regression approach, we find that both extension access and cooperative membership have a positive and statistically significant effect on technology adoption and household welfare. Moreover, we find that both extension access and cooperative membership have heterogeneous impacts. In particular, we find evidence of a positive selection as the average treatment effects of extension access and cooperative membership are higher for farmers with the highest propensity to access extension and cooperative services. The impact of extension services on poverty reduction and of cooperatives on technology adoption is significantly stronger for smallholders with access to formal credit than for those without access. This implies that expanding rural financial markets can maximize the potential positive impacts of extension and cooperative services on farmers' productivity and welfare.

  9. Exploring Factors Associated with the Psychosocial Impact of Stigma Among People with Schizophrenia or Affective Disorders.

    Science.gov (United States)

    Świtaj, Piotr; Chrostek, Anna; Grygiel, Paweł; Wciórka, Jacek; Anczewska, Marta

    2016-04-01

    Stigmatization can exert a variety of pernicious effects on the lives of persons with mental illnesses. The purpose of this study was to explore factors related to the psychosocial impact of stigma among 229 people receiving psychiatric treatment: 123 with schizophrenia [International Classification of Diseases, 10th Revision (ICD-10): F20] and 106 with affective disorders (ICD-10: F31-F33). In the whole sample, the factors most prominently associated with a greater impact of stigma on personal and family life were schizophrenia diagnosis, current inpatient treatment, actually experienced stigma and self-stigma. However, the patterns of predictors varied between the two diagnostic categories. For the schizophrenia group, only self-stigma significantly contributed to a stronger stigma impact. In the affective group, a more severe impact of stigma was significantly predicted by inpatient status and experienced stigma. Anti-stigma programs should address the specific features of stigmatization associated with various psychiatric diagnoses.

  10. Grazing Impact Oscillations

    NARCIS (Netherlands)

    Weger, J.G.; Water, van de W.; Molenaar, J.

    2000-01-01

    An impact oscillator is a periodically driven system that hits a wall when its amplitude exceeds a critical value. We study impact oscillations where collisions with the wall are with near-zero velocity (grazing impacts). A characteristic feature of grazing impact dynamics is a geometrically

  11. Impacts of low-skilled immigration on the internal migration of the U.S.-born low-skilled Americans in the United States: an assessment in a multivariate context.

    Science.gov (United States)

    Liaw, K L; Lin, J P; Frey, W H

    1998-11-01

    "This paper assesses the impacts of low-skilled immigration on the interstate migration of...U.S.-born low-skilled Americans, based on the disaggregated data of the 1990 Census. Our results reveal that the push effects of...immigration on the departure process [were] much stronger than its discouraging and complementary effects on the destination choice process; and that the push effects of low-skilled immigration are (1) stronger on whites than on non-whites, (2) much stronger on the poor than on the non-poor, (3) weaker on the 15-24 age group than on older age groups, and (4) the strongest on poor whites." excerpt

  12. The impact of calcium current reversal on neurotransmitter release in the electrically stimulated retina

    Science.gov (United States)

    Werginz, Paul; Rattay, Frank

    2016-08-01

    Objective. In spite of intense theoretical and experimental investigations on electrical nerve stimulation, the influence of reversed ion currents on network activity during extracellular stimulation has not been investigated so far. Approach. Here, the impact of calcium current reversal on neurotransmitter release during subretinal stimulation was analyzed with a computational multi-compartment model of a retinal bipolar cell (BC) that was coupled with a four-pool model for the exocytosis from its ribbon synapses. Emphasis was laid on calcium channel dynamics and how these channels influence synaptic release. Main results. Stronger stimulation with anodic pulses caused transmembrane voltages above the Nernst potential of calcium in the terminals and, by this means, forced calcium ions to flow in the reversed direction from inside to the outside of the cell. Consequently, intracellular calcium concentration decreased resulting in a reduced vesicle release or preventing release at all. This mechanism is expected to lead to a pronounced ring-shaped pattern of exocytosis within a group of neighbored BCs when the stronger stimulated cells close to the electrode fail in releasing vesicles. Significance. Stronger subretinal stimulation causes failure of synaptic exocytosis due to reversal of calcium flow into the extracellular space in cells close to the electrode.

  13. Impact of aircraft exhaust on the atmosphere. Box model studies and 3-D mesoscale numerical case studies of seasonal differences

    Energy Technology Data Exchange (ETDEWEB)

    Petry, H.; Ebel, A.; Franzkowiak, V.; Hendricks, J.; Lippert, E.; Moellhoff, M. [Koeln Univ. (Germany). Inst. fuer Geophysik und Meteorologie

    1997-12-31

    The impact of aircraft emissions released in the tropopause region on atmospheric trace gases as O{sub 3} or HNO{sub 3} is investigated by means of model studies. Special emphasis is drawn on seasonal effects. A box model is applied as well as a 3-D mesoscale chemistry transport model. These model studies show that the impact of aircraft emissions on ozone in the tropopause region is much stronger in summer than in late autumn with a difference of one order of magnitude. (author) 14 refs.

  14. Impactitis: The impact factor myth syndrome

    Directory of Open Access Journals (Sweden)

    Elsaie Mohamed

    2009-01-01

    Full Text Available Background : In the early 1960s, Eugene Garfield and Irving Sher created the journal impact factor to help select journals for the Science Citation Index (SCI. Today it has become a widespread subject of controversy even for Garfield, the man who created it who is quoted saying " Impact Factor is not a perfect tool to measure the quality of articles but there is nothing better and it has the advantage of already being in existence and is, therefore, a good technique for scientific evaluation". The use of the term "impact factor" has gradually evolved, especially in Europe, to include both journal and author impact. This ambiguity often causes problems. It is one thing to use impact factors to compare journals and quite another to use them to compare authors. Journal impact factors generally involve relatively large populations of articles and citations. Individual authors, on average, produce much smaller numbers of articles. Objectives: Impact factor, an index based on the frequency with which a journal′s articles are cited in scientific publications, is a putative marker of journal quality. However, empiric studies on impact factor′s validity as an indicator of quality are lacking. The authors try to evaluate and highlight the validity of Impact Factors and its significance as a tool of assessment for scientific publications. Methods: Analysis of the several reports in literature and from their own point of view. Conclusion: A journal′s impact factor is based on 2 elements: the numerator, which is the number of citations in the current year to any items published in a journal in the previous 2 years, and the denominator, which is the number of substantive articles (source items published in the same 2 years. The impact factor could just as easily be based on the previous year′s articles alone, which would give an even greater weight to rapidly changing fields.

  15. A meta-analysis of seaweed impacts on seagrasses: generalities and knowledge gaps.

    Directory of Open Access Journals (Sweden)

    Mads S Thomsen

    Full Text Available Seagrasses are important habitat-formers and ecosystem engineers that are under threat from bloom-forming seaweeds. These seaweeds have been suggested to outcompete the seagrasses, particularly when facilitated by eutrophication, causing regime shifts where green meadows and clear waters are replaced with unstable sediments, turbid waters, hypoxia, and poor habitat conditions for fishes and invertebrates. Understanding the situations under which seaweeds impact seagrasses on local patch scales can help proactive management and prevent losses at greater scales. Here, we provide a quantitative review of available published manipulative experiments (all conducted at the patch-scale, to test which attributes of seaweeds and seagrasses (e.g., their abundances, sizes, morphology, taxonomy, attachment type, or origin influence impacts. Weighted and unweighted meta-analyses (Hedges d metric of 59 experiments showed generally high variability in attribute-impact relationships. Our main significant findings were that (a abundant seaweeds had stronger negative impacts on seagrasses than sparse seaweeds, (b unattached and epiphytic seaweeds had stronger impacts than 'rooted' seaweeds, and (c small seagrass species were more susceptible than larger species. Findings (a and (c were rather intuitive. It was more surprising that 'rooted' seaweeds had comparatively small impacts, particularly given that this category included the infamous invasive Caulerpa species. This result may reflect that seaweed biomass and/or shading and metabolic by-products like anoxia and sulphides could be lower for rooted seaweeds. In conclusion, our results represent simple and robust first-order generalities about seaweed impacts on seagrasses. This review also documented a limited number of primary studies. We therefore identified major knowledge gaps that need to be addressed before general predictive models on seaweed-seagrass interactions can be build, in order to effectively

  16. A meta-analysis of seaweed impacts on seagrasses: generalities and knowledge gaps.

    Science.gov (United States)

    Thomsen, Mads S; Wernberg, Thomas; Engelen, Aschwin H; Tuya, Fernando; Vanderklift, Mat A; Holmer, Marianne; McGlathery, Karen J; Arenas, Francisco; Kotta, Jonne; Silliman, Brian R

    2012-01-01

    Seagrasses are important habitat-formers and ecosystem engineers that are under threat from bloom-forming seaweeds. These seaweeds have been suggested to outcompete the seagrasses, particularly when facilitated by eutrophication, causing regime shifts where green meadows and clear waters are replaced with unstable sediments, turbid waters, hypoxia, and poor habitat conditions for fishes and invertebrates. Understanding the situations under which seaweeds impact seagrasses on local patch scales can help proactive management and prevent losses at greater scales. Here, we provide a quantitative review of available published manipulative experiments (all conducted at the patch-scale), to test which attributes of seaweeds and seagrasses (e.g., their abundances, sizes, morphology, taxonomy, attachment type, or origin) influence impacts. Weighted and unweighted meta-analyses (Hedges d metric) of 59 experiments showed generally high variability in attribute-impact relationships. Our main significant findings were that (a) abundant seaweeds had stronger negative impacts on seagrasses than sparse seaweeds, (b) unattached and epiphytic seaweeds had stronger impacts than 'rooted' seaweeds, and (c) small seagrass species were more susceptible than larger species. Findings (a) and (c) were rather intuitive. It was more surprising that 'rooted' seaweeds had comparatively small impacts, particularly given that this category included the infamous invasive Caulerpa species. This result may reflect that seaweed biomass and/or shading and metabolic by-products like anoxia and sulphides could be lower for rooted seaweeds. In conclusion, our results represent simple and robust first-order generalities about seaweed impacts on seagrasses. This review also documented a limited number of primary studies. We therefore identified major knowledge gaps that need to be addressed before general predictive models on seaweed-seagrass interactions can be build, in order to effectively protect

  17. A Meta-Analysis of Seaweed Impacts on Seagrasses: Generalities and Knowledge Gaps

    Science.gov (United States)

    Thomsen, Mads S.; Wernberg, Thomas; Engelen, Aschwin H.; Tuya, Fernando; Vanderklift, Mat A.; Holmer, Marianne; McGlathery, Karen J.; Arenas, Francisco; Kotta, Jonne; Silliman, Brian R.

    2012-01-01

    Seagrasses are important habitat-formers and ecosystem engineers that are under threat from bloom-forming seaweeds. These seaweeds have been suggested to outcompete the seagrasses, particularly when facilitated by eutrophication, causing regime shifts where green meadows and clear waters are replaced with unstable sediments, turbid waters, hypoxia, and poor habitat conditions for fishes and invertebrates. Understanding the situations under which seaweeds impact seagrasses on local patch scales can help proactive management and prevent losses at greater scales. Here, we provide a quantitative review of available published manipulative experiments (all conducted at the patch-scale), to test which attributes of seaweeds and seagrasses (e.g., their abundances, sizes, morphology, taxonomy, attachment type, or origin) influence impacts. Weighted and unweighted meta-analyses (Hedges d metric) of 59 experiments showed generally high variability in attribute-impact relationships. Our main significant findings were that (a) abundant seaweeds had stronger negative impacts on seagrasses than sparse seaweeds, (b) unattached and epiphytic seaweeds had stronger impacts than ‘rooted’ seaweeds, and (c) small seagrass species were more susceptible than larger species. Findings (a) and (c) were rather intuitive. It was more surprising that ‘rooted’ seaweeds had comparatively small impacts, particularly given that this category included the infamous invasive Caulerpa species. This result may reflect that seaweed biomass and/or shading and metabolic by-products like anoxia and sulphides could be lower for rooted seaweeds. In conclusion, our results represent simple and robust first-order generalities about seaweed impacts on seagrasses. This review also documented a limited number of primary studies. We therefore identified major knowledge gaps that need to be addressed before general predictive models on seaweed-seagrass interactions can be build, in order to effectively

  18. Impacts of Boundary Conditions on the Simulation of Atmospheric Fields Using RegCM4 over CORDEX East Asia

    Directory of Open Access Journals (Sweden)

    Myoung Seok Suh

    2015-06-01

    Full Text Available The impacts of boundary conditions (BCs on simulations of RegCM4 for mid-to-upper atmospheric fields over the CORDEX (COordinated Regional Downscaling EXperiment East Asia domain were investigated using two datasets from integrations over 20 years (1989–2008 with two BCs (ERA and R2. The two datasets showed large differences for the atmospheric variables regardless of the geographic locations, heights, and seasons. The ERA dataset at 850 hPa displayed stronger northerly winds in the western Pacific Ocean, colder temperatures around northern India, and higher relative humidity compared with the R2 dataset during summer. The large differences in the BCs resulted in the significantly different simulations of RegCM4 in both surface and atmospheric variables. The temperatures and wind simulated at 850 hPa with the ERA dataset were warmer and stronger, respectively, than those simulated with the R2 dataset during summer. In addition, RegCM4 with the ERA dataset as a BC generally simulated a stronger southerly wind at 850 hPa over eastern China and more unstable environments than with the R2 dataset, and accordingly generated more precipitation over the eastern part of the domain. Contrary to the forcing data, the trends of simulated relative humidity and the mixing ratios from the two different BCs showed similar patterns irrespective of height and season. The significant impacts of the BCs on the simulation results indicate the importance of BCs in regional climate simulations.

  19. Does cyberbullying impact youth suicidal behaviors?

    Science.gov (United States)

    Nikolaou, Dimitrios

    2017-12-01

    Even though several youth fatal suicides have been linked with school victimization, there is lack of evidence on whether cyberbullying victimization causes students to adopt suicidal behaviors. To investigate this issue, I use exogenous state-year variation in cyberbullying laws and information on high school students from the Youth Risk Behavioral Survey within a bivariate probit framework, and complement these estimates with matching techniques. I find that cyberbullying has a strong impact on all suicidal behaviors: it increases suicidal thoughts by 14.5 percentage points and suicide attempts by 8.7 percentage points. Even if the focus is on statewide fatal suicide rates, cyberbullying still leads to significant increases in suicide mortality, with these effects being stronger for men than for women. Since cyberbullying laws have an effect on limiting cyberbullying, investing in cyberbullying-preventing strategies can improve individual health by decreasing suicide attempts, and increase the aggregate health stock by decreasing suicide rates. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Caregiver Burden in Epilepsy: Determinants and Impact

    Directory of Open Access Journals (Sweden)

    Ioannis Karakis

    2014-01-01

    Full Text Available Aim. Caregiver burden (CB in epilepsy constitutes an understudied area. Here we attempt to identify the magnitude of this burden, the factors associated with it, and its impact to caregiver quality of life (QOL. Methods. 48 persons with epilepsy (PWE underwent video-EEG monitoring and their caregivers completed questionnaires providing demographic, disease-related, psychiatric, cognitive, sleep, QOL, and burden information. Results. On regression analysis, higher number of antiepileptic drugs, poorer patient neuropsychological performance, lower patient QOL score, and lower caregiver education level were associated with higher CB. Time allocated to patient care approximated but did not attain statistical significance. A moderate inverse correlation between CB and caregiver QOL physical component summary score and a stronger inverse correlation between CB and caregiver QOL mental component summary score were seen. Conclusion. In a selected cohort of PWE undergoing video-EEG monitoring, we identified modest degree of CB, comparable to that reported in the literature for other chronic neurological conditions. It is associated with specific patient and caregiver characteristics and has a negative effect on caregiver QOL.

  1. Evaluating impacts of unexpected earning on precision of profit estimation

    Directory of Open Access Journals (Sweden)

    Hossein Kazemi

    2013-03-01

    Full Text Available Precision in earning report has always been a concern among investors, and when there are some negative adjustments on earning, investor may find it challenging to decide whether they should hold or sell their shares. This paper studies the impact of earning precision and unexpected earning adjustments on firms whose share are listed on Tehran Stock Exchange. The proposed study of this paper considers three hypotheses including whether earning precision has negative relationship with unexpected profit, whether it has a negative with unexpected decline in profit and finally, whether, in prediction on negative news compared with positive news, there is a negative relationship between stronger earnings forecast and precision of earning forecast. The study gathers the necessary data from official news released for some firms whose shares were active over the period 2003-2012. The study uses two regression models and the results of regression analysis have confirmed all hypotheses of this survey.

  2. Antenna Gain Impact on UWB Wind Turbine Blade Deflection Sensing

    DEFF Research Database (Denmark)

    Zhang, Shuai; Franek, Ondrej; Byskov, Claus

    2018-01-01

    effective (or equivalent) isotropic radiated power (EIRP), an HG tip antenna inside a blade gives stronger direct pulse amplitudes and better pulse waveforms for accurate and reliable distance estimations than the LG. Moreover, the direct pulse with the HG antenna is also closer to the blade surface, which...... a blade). Higher antenna gain enlarges both direct pulse and multipath but in different levels. To verify the simulations, time-domain measurements are performed with a full 37-meter blade. Pulse waveforms and power delay profiles are measured. From all the studies, it follows that: with the similar......Antenna gain impact on UWB wind turbine blade deflection sensing is studied in this paper. Simulations are applied with a 4.5-meter blade tip. The antennas with high gain (HG) and low gain (LG) in free space are simulated inside a blade. It is interesting to find that tip antennas with HG and LG...

  3. Team Structure and Scientific Impact of "Big Science" Research

    DEFF Research Database (Denmark)

    Lauto, Giancarlo; Valentin, Finn; Jeppesen, Jacob

    of the Neutron Science Department of Oak Ridge National Laboratories in 2006-2009. Given the collaborative nature of research carried out at LSRFs, it is important to understand how its organization affects scientific impact. Diversity of teams along the institutional and cognitive dimensions affects both...... Laboratories. iii.). Knowledge integration at the level of individual scientists clearly outperforms team level integration. iv.) Team diversity is associated with stronger performance in basic research than in applied research. Implications for the organisation of research collaboration of LSRFs...... the facility and to an external university of research laboratory (secondments) out-perform all other types of institutional affiliations. ii.) Teams spanning multiple institutional types have the lowest performance. This is the case whether or not teams include resident scientists from Oak Ridge National...

  4. IMPROVED BAR IMPACT TESTS USING A PHOTONIC DOPPLER VELOCIMETER

    Energy Technology Data Exchange (ETDEWEB)

    Bless, S J; Tolman, J; Levinson, S; Nguyen, J

    2009-08-24

    Bar impact tests, using the techniques described elsewhere in this symposium, were used to measure compressive and tensile strengths of borosilicate glass, soda lime glass, and a glass ceramic. The glass ceramic was 25% crystalline spinel, furnished by Corning Inc. There are two measures of compressive strength: the peak stress that can be transmitted in unconfined compression, and the 'steady state' strength. For borosilicate glass and soda lime glass, these values were similar, being about 1.8 and 1.5 GPa, respectively. The glass ceramic (25% spinel) was almost 50% stronger. Tensile failure in the glass and glass ceramic takes places via surface flaws, and thus tensile strength is an extrinsic, as opposed to intrinsic property.

  5. Antenna Gain Impact on UWB Wind Turbine Blade Deflection Sensing

    DEFF Research Database (Denmark)

    Zhang, Shuai; Franek, Ondrej; Byskov, Claus

    2018-01-01

    effective (or equivalent) isotropic radiated power (EIRP), an HG tip antenna inside a blade gives stronger direct pulse amplitudes and better pulse waveforms for accurate and reliable distance estimations than the LG. Moreover, the direct pulse with the HG antenna is also closer to the blade surface, which...... in free space have similar realized gain when allocated inside blades, so that the emission power for the HG and LG antennas in blades can be the same. The antenna gain impacts on time-domain pulse waveforms and power distributions around a blade are carefully investigated (with the tip antenna inside...... a blade). Higher antenna gain enlarges both direct pulse and multipath but in different levels. To verify the simulations, time-domain measurements are performed with a full 37-meter blade. Pulse waveforms and power delay profiles are measured. From all the studies, it follows that: with the similar...

  6. The Impacts of Different Expansion Modes on Performance of Small Solar Energy Firms: Perspectives of Absorptive Capacity

    Directory of Open Access Journals (Sweden)

    Hsing Hung Chen

    2013-01-01

    Full Text Available The characteristics of firm’s expansion by differentiated products and diversified products are quite different. However, the study employing absorptive capacity to examine the impacts of different modes of expansion on performance of small solar energy firms has never been discussed before. Then, a conceptual model to analyze the tension between strategies and corporate performance is proposed to filling the vacancy. After practical investigation, the results show that stronger organizational institutions help small solar energy firms expanded by differentiated products increase consistency between strategies and corporate performance; oppositely, stronger working attitudes with weak management controls help small solar energy firms expanded by diversified products reduce variance between strategies and corporate performance.

  7. Impact of celebrity pitch in direct-to-consumer advertising of prescription drugs.

    Science.gov (United States)

    Bhutada, Nilesh S; Menon, Ajit M; Deshpande, Aparna D; Perri, Matthew

    2012-01-01

    Online surveys were conducted to determine the impact of endorser credibility, endorser effectiveness, and consumers' involvement in direct-to-consumer advertising. In a randomized posttest only study, using the elaboration likelihood model, survey participants (U.S. adults) were either exposed to a fictitious prescription drug ad with a celebrity or a noncelebrity endorser. There was no significant difference in credibility and effectiveness between the celebrity and the noncelebrity endorser. High involvement consumers viewed the ad more favorably and exhibited significantly stronger drug inquiry intentions during their next doctor visit. Further, consumers' involvement did not moderate the effect of celebrity endorser.

  8. The Impact of Leader-member Exchange (LMX and Empowerment on Employee Voice Behavior

    Directory of Open Access Journals (Sweden)

    Chan Simon C. H.

    2016-06-01

    Full Text Available This study examines the impact of leader-member exchange (LMX and the moderating role of empowerment on employee voice behavior. A sample of 314 supervisor-subordinate dyadic exchanges was collected from a manufacturing firm in Mainland China. The results provided support the view that LMX and empowerment were both significantly associated with employee voice behavior. The positive relationship between LMX and employee voice behavior was stronger when employees received higher levels of empowerment. Theoretical and managerial implications of the research are discussed.

  9. Does Neglect Moderate the Impact of an Efficacious Preventive Intervention for Maltreated Children in Foster Care?

    Science.gov (United States)

    Taussig, Heather N.; Culhane, Sara E.; Garrido, Edward; Knudtson, Michael D.; Petrenko, Christie L. M.

    2015-01-01

    Physically neglected youth are at increased risk for mental health problems, but there are few interventions that have demonstrated efficacy in reducing mental health symptoms for this vulnerable population. The Fostering Healthy Futures (FHF) program, which consists of mentoring and skills groups, was developed for preadolescent youth in foster care. In a published randomized controlled trial with 156 youth, FHF demonstrated positive impacts on mental health functioning. The current study sought to determine whether FHF might be particularly effective in ameliorating the impact of neglectful family environments. Because it was not possible to isolate a neglected-only subgroup, as most children with physical neglect histories had experienced other types of maltreatment, we tested the hypothesis that intervention effects would be stronger among children with more severe physical neglect. Findings did not support this hypothesis, however, as severity of physical neglect did not significantly moderate the impact of the intervention on psychosocial outcomes PMID:23076837

  10. Comparison of the PCI distortion effects on the Auger lineshape for electron and photon impact ionization

    International Nuclear Information System (INIS)

    Paripas, B.; Vitez, G.; Vikor, Gy.; Tokesi, K.; Sankari, R.; Calo, A.

    2005-01-01

    The distortion effects of the post-collision interaction (PCI) on the Ar LMM Auger electron lineshape for electron and photon impact ionization have been calculated. The calculations were based on the eikonal model of Kuchiev and Sheinerman [Sov. Phys. - Tech. Phys. 32 (1987) 879]. It is shown that the Auger peak asymmetry depends on the emission angle of the Auger electron relative to the primary beam (and the polarization vector of the photon beam). At a given excess energy, defined as the difference between the impact energy and the binding energy, the absolute value of the Auger peak asymmetry is always larger for electron impact ionization than for photoionization. At the same time, the angular dependence of the PCI distortion is stronger for photoionization. In both cases the Auger peak asymmetry has a maximum when the energy of the ejected electron and that of the Auger electron are nearly equal. The calculations are in good agreement with our previous experimental results

  11. Impact of parenting practices on adolescent achievement: authoritative parenting, school involvement, and encouragement to succeed.

    Science.gov (United States)

    Steinberg, L; Lamborn, S D; Dornbusch, S M; Darling, N

    1992-10-01

    This article examines the impact of authoritative parenting, parental involvement in schooling, and parental encouragement to succeed on adolescent school achievement in an ethnically and socio-economically heterogeneous sample of approximately 6,400 American 14-18-year-olds. Adolescents reported in 1987 on their parents' general child-rearing practices and on their parents' achievement-specific socialization behaviors. In 1987, and again in 1988, data were collected on several aspects of the adolescents' school performance and school engagement. Authoritative parenting (high acceptance, supervision, and psychological autonomy granting) leads to better adolescent school performance and stronger school engagement. The positive impact of authoritative parenting on adolescent achievement, however, is mediated by the positive effect of authoritativeness on parental involvement in schooling. In addition, nonauthoritativeness attenuates the beneficial impact of parental involvement in schooling on adolescents achievement. Parental involvement is much more likely to promote adolescent school success when it occurs in the context of an authoritative home environment.

  12. Impacted Wisdom Teeth

    Science.gov (United States)

    Impacted wisdom teeth Overview Impacted wisdom teeth are third molars at the back of the mouth that don't have enough room to ... to tooth decay and gum disease than other teeth are. Impacted wisdom teeth that cause pain or other dental ...

  13. Impacted wisdom teeth

    OpenAIRE

    Dodson, Thomas B.; Susarla, Srinivas M.

    2014-01-01

    Impacted wisdom teeth (third molars) occur because of a lack of space, obstruction, or abnormal position. They can cause pain, swelling, and infection, and may destroy adjacent teeth and bone.The incidence of impacted wisdom teeth is high, with some 72% of Swedish people aged 20 to 30 years having at least one impacted wisdom tooth.

  14. Impacted wisdom teeth

    OpenAIRE

    Dodson, Thomas B; Susarla, Srinivas M

    2010-01-01

    Impacted wisdom teeth occur because of a lack of space, obstruction, or abnormal position. They can cause pain, swelling, and infection, and may destroy adjacent teeth and bone.The incidence of impacted wisdom teeth is high, with some 72% of Swedish people aged 20 to 30 years having at least one impacted third molar.

  15. The impact of direct-to-consumer television and magazine advertising on antidepressant use.

    Science.gov (United States)

    Avery, Rosemary J; Eisenberg, Matthew D; Simon, Kosali I

    2012-09-01

    We examine whether exposure to direct-to-consumer advertising (DTCA) for antidepressant drugs affects individual use of these medications among those suffering from depression. Prior studies have almost exclusively relied on making connections between national or market-level advertising volume/expenditures and national or individual-level usage of medications. This is the first study to: estimate the impact of individual-level exposure to DTCA on individual-level use of antidepressants; estimate the impact of individual-level exposure to television DTCA on individual-level use in any drug class; consider the relative and interactive impact of DTCA in two different media in any drug class; and, consider the heterogeneity of impact among different populations in an econometric framework in the antidepressant market. There are also important limitations to note. Unlike prior market level studies that use monthly data, we are limited to aggregated annual data. Our measures of potential advertising exposure are constructed assuming that media consumption patterns are stable during the year. We are also not able to study the impact of advertising on use of antidepressants for conditions other than depression, such as anxiety disorders. We find that: DTCA impacts antidepressant use in a statistically and economically significant manner; that these effects are present in both television and magazine advertising exposure but do not appear to have interactive effects; are stronger for women than for men in the magazine medium, but are about equally strong for men and women in the TV medium; and, are somewhat stronger for groups suffering from more severe forms of depression. The overall size of the effect is a 6-10 percentage point increase in antidepressant use from being exposed to television advertising; the corresponding magazine effects are between 3 and 4 percentage points. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Environment, Health and Climate: Impact of African aerosols

    Science.gov (United States)

    Liousse, C.; Doumbia, T.; Assamoi, E.; Galy-Lacaux, C.; Baeza, A.; Penner, J. E.; Val, S.; Cachier, H.; Xu, L.; Criqui, P.

    2012-12-01

    carbon particles have appeared quite biologically active. Quite importantly, air quality improvement obtained through regulations in the ccc* scenario are accompanied by stronger heating impact.

  17. Jupiter G Impact Evolution

    Science.gov (United States)

    1995-01-01

    This mosaic of WFPC-2 images shows the evolution of the Shoemaker-Levy 9 G impact site on Jupiter. The images from lower left to upper right show: the impact plume at 07/18/94 07:38 UT (about 5 minutes after the impact); the fresh impact site at 07/18/94 at 09:19 UT (1.5 hours after impact); the impact site after evolution by the winds of Jupiter (left), along with the L impact (right), taken on 07/21/94 at 6:22 UT (3 days after the G impact and 1.3 days after the L impact); and further evolution of the G and L sites due to winds and an additional impact (S) in the G vicinity, taken on 07/23/94 at 08:08 UT (5 days after the G impact).This image and other images and data received from the Hubble Space Telescope are posted on the World Wide Web on the Space Telescope Science Institute home page at URL http://oposite.stsci.edu/pubinfo/

  18. Change We can Believe in? Reviewing Studies on the Conservation Impact of Popular Participation in Forest Management

    Directory of Open Access Journals (Sweden)

    Lund Jens

    2009-01-01

    Full Text Available This article presents a review of methods in 60 empirical studies on forest conservation impact of popular participation in forest management. The review illustrates a high degree of variance in methods among the studies, and shows that a majority of the studies could benefit from a stronger focus on one or more of the following three areas: (i the empirical verification and characterisation of popular participation as it exists on the ground, (ii the indicators of impact and the method used to assess them, and (iii the disentanglement of the effect of popular participation from other developments in the study area that may impact on forest condition. The variation in methods inhibits comparisons and meta-analyses, as well as questions the basis on which policy recommendations on popular participation in forest management are made. Based on the review, we provide recommendations for future evaluations of the conservation impact of popular participation in forest management.

  19. Beliefs about the Potential Impacts of Exploiting Non-Timber Forest Products Predict Voluntary Participation in Monitoring.

    Science.gov (United States)

    Dantas Brites, Alice; Morsello, Carla

    2017-06-01

    Harvesting and trading non-timber forest products is advocated as a win-win strategy for conservation and development, yet it can produce negative ecological and socioeconomic impacts. Hence, monitoring exploitation outcomes is essential, and participatory monitoring has been suggested to be the most suitable approach. Among possible approaches, participatory monitoring is preferred because it is likely to increase people's awareness and beliefs regarding impacts or potential impacts, thus inducing behavioral changes, although the evidence in this regard is contradictory. We therefore evaluated whether people's beliefs about the potential ecological and socioeconomic impacts of non-timber forest product exploitation increased their likelihood of volunteering to monitor. We studied a community of forest inhabitants in the Brazilian Amazon who harvested and traded a commercially important non-timber forest product. Two methods of data gathering were employed: (i) a survey of 166 adults (51 households) to evaluate people's beliefs and their stated intention to engage in four different monitoring tasks and (ii) four pilot monitoring tasks to evaluate who actually participated. Based on mixed-effects regressions, the results indicated that beliefs regarding both types of impacts could predict participation in certain tasks, although gender, age and schooling were occasionally stronger predictors. On average, people had stronger beliefs about potential socioeconomic impacts than about potential ecological impacts, with the former also predicting participation in ecological data gathering. This finding reinforces the importance of monitoring both types of impacts to help achieve the win-win outcomes originally proposed by non-timber forest product trade initiatives.

  20. Beliefs about the Potential Impacts of Exploiting Non-Timber Forest Products Predict Voluntary Participation in Monitoring

    Science.gov (United States)

    Dantas Brites, Alice; Morsello, Carla

    2017-06-01

    Harvesting and trading non-timber forest products is advocated as a win-win strategy for conservation and development, yet it can produce negative ecological and socioeconomic impacts. Hence, monitoring exploitation outcomes is essential, and participatory monitoring has been suggested to be the most suitable approach. Among possible approaches, participatory monitoring is preferred because it is likely to increase people's awareness and beliefs regarding impacts or potential impacts, thus inducing behavioral changes, although the evidence in this regard is contradictory. We therefore evaluated whether people's beliefs about the potential ecological and socioeconomic impacts of non-timber forest product exploitation increased their likelihood of volunteering to monitor. We studied a community of forest inhabitants in the Brazilian Amazon who harvested and traded a commercially important non-timber forest product. Two methods of data gathering were employed: (i) a survey of 166 adults (51 households) to evaluate people's beliefs and their stated intention to engage in four different monitoring tasks and (ii) four pilot monitoring tasks to evaluate who actually participated. Based on mixed-effects regressions, the results indicated that beliefs regarding both types of impacts could predict participation in certain tasks, although gender, age and schooling were occasionally stronger predictors. On average, people had stronger beliefs about potential socioeconomic impacts than about potential ecological impacts, with the former also predicting participation in ecological data gathering. This finding reinforces the importance of monitoring both types of impacts to help achieve the win-win outcomes originally proposed by non-timber forest product trade initiatives.

  1. Impact Effects Calculator. Orbital Parameters.

    Science.gov (United States)

    Glazachev, D.; Naroenkov, S.; Kartashova, A.; Turuntaev, I.; Svetsov, V.; Shuvalov, V.; Popova, O.; Podobnaya, E.

    2017-09-01

    Next-generation Impact Calculator for quick assessment of impact consequences is preparing. The estimates of impact effects are revised. The possibility to manipulate with the orbital parameters and to determine impact point is included.

  2. Environmental impact statements

    International Nuclear Information System (INIS)

    Stewing, C.

    1986-01-01

    The adoption of US-type environmental impact statements is considered to be approaching. Environmental impact statements are defined as comprehensive analyses of the future effects of measures on environmental conditions with the aim of avoiding ecological disadvantages. The recommendation ratified by the European Communities on June 27, 1985 requires the environmental impact statement to be implemented as a mandatory procedure. The implementation is difficult to realize. Particular problems consist in the alignment of the environmental impact statement with existing administrative procedures and in the operationable formulation of the aims and results of the statement. Paragraph 72 of the administrative procedures law (VwVfG) shows that planning procedures and environmental impact statement are to be treated as two parallel regulations. The structural order of environmental impact statements must therefore be integrated into the regulations of planning procedures. (orig./HP) [de

  3. Impact assessment revisited

    DEFF Research Database (Denmark)

    Thiele, Jan; Kollmann, Johannes Christian; Markussen, Bo

    2010-01-01

    The theoretical underpinnings of the assessment of invasive alien species impacts need to be improved. At present most approaches are unreliable to quantify impact at regional scales and do not allow for comparison of different invasive species. There are four basic problems that need......; and (4) the total invaded range is an inappropriate measure for quantifying regional impact because the habitat area available for invasion can vary markedly among invasive species. Mathematical models and empirical data using an invasive alien plant species (Heracleum mantegazzianum) indicate...... to be addressed: (1) Some impacted ecosystem traits are spatially not additive; (2) invader effects may increase non-linearly with abundance or there may be effect thresholds impairing estimates of linear impact models; (3) the abundance and impact of alien species will often co-vary with environmental variation...

  4. Head Impact Laboratory (HIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The HIL uses testing devices to evaluate vehicle interior energy attenuating (EA) technologies for mitigating head injuries resulting from head impacts during mine/...

  5. Meteoroids Impact the Moon

    Science.gov (United States)

    Moser, D. E.

    2017-01-01

    Most meteoroids are broken up by Earth's atmosphere before they reach the ground. The Moon, however, has little-to-no atmosphere to prevent meteoroids from impacting the lunar surface. Upon impact they excavate a crater and generate a plume of debris. A flash of light at the moment of impact can also be seen. Meteoroids striking the Moon create an impact flash observable by telescopes here on Earth. NASA observers use telescopes at the Automated Lunar and Meteor Observatory (ALaMO) to routinely monitor the Moon for impact flashes each month when the lunar phase is right. Flashes recorded by two telescope simultaneously rule out false signals from cosmic rays and satellites. Over 400 impact flashes have been observed by NASA since 2005. This map shows the location of each flash. No observations are made near the poles or center line. On average, one impact is observed every two hours. The brightest and longest-lasting impact flash was observed in Mare Imbrium on March 17, 2013. The imaging satellite Lunar Reconnaissance Orbiter, in orbit around the Moon, discovered the fresh crater created by this impact. The crater is 60 across and was caused by a meteoroid 9 inches in diameter likely traveling at a speed of 57,000 mph!

  6. Impacts of half a degree additional warming on the Asian summer monsoon rainfall characteristics

    Science.gov (United States)

    Lee, Donghyun; Min, Seung-Ki; Fischer, Erich; Shiogama, Hideo; Bethke, Ingo; Lierhammer, Ludwig; Scinocca, John F.

    2018-04-01

    This study investigates the impacts of global warming of 1.5 °C and 2.0 °C above pre-industrial conditions (Paris Agreement target temperatures) on the South Asian and East Asian monsoon rainfall using five atmospheric global climate models participating in the ‘Half a degree Additional warming, Prognosis and Projected Impacts’ (HAPPI) project. Mean and extreme precipitation is projected to increase under warming over the two monsoon regions, more strongly in the 2.0 °C warmer world. Moisture budget analysis shows that increases in evaporation and atmospheric moisture lead to the additional increases in mean precipitation with good inter-model agreement. Analysis of daily precipitation characteristics reveals that more-extreme precipitation will have larger increase in intensity and frequency responding to the half a degree additional warming, which is more clearly seen over the South Asian monsoon region, indicating non-linear scaling of precipitation extremes with temperature. Strong inter-model relationship between temperature and precipitation intensity further demonstrates that the increased moisture with warming (Clausius-Clapeyron relation) plays a critical role in the stronger intensification of more-extreme rainfall with warming. Results from CMIP5 coupled global climate models under a transient warming scenario confirm that half a degree additional warming would bring more frequent and stronger heavy precipitation events, exerting devastating impacts on the human and natural system over the Asian monsoon region.

  7. The economic impact of state cigarette taxes and smoke-free air policies on convenience stores.

    Science.gov (United States)

    Huang, Jidong; Chaloupka, Frank J

    2013-03-01

    To investigate whether increasing state cigarette taxes and/or enacting stronger smoke-free air (SFA) policies have negative impact on convenience store density in a state, a proxy that is determined by store openings and closings, which reflects store profits. State-level business count estimates for convenience stores for 50 states and District of Columbia from 1997 to 2009 were analysed using two-way fixed effects regression techniques that control for state-specific and year-specific determinants of convenience store density. The impact of tax and SFA policies was examined using a quasi-experimental research design that exploits changes in cigarette taxes and SFA policies within a state over time. Taxes are found to be uncorrelated with the density of combined convenience stores and gas stations in a state. Taxes are positively correlated with the density of convenience stores; however, the magnitude of this correlation is small, with a 10% increase in state cigarette taxes associated with a 0.19% (phigher cigarette taxes and stronger SFA policies do not negatively affect convenience stores.

  8. STRONG SOLAR WIND DYNAMIC PRESSURE PULSES: INTERPLANETARY SOURCES AND THEIR IMPACTS ON GEOSYNCHRONOUS MAGNETIC FIELDS

    International Nuclear Information System (INIS)

    Zuo, Pingbing; Feng, Xueshang; Wang, Yi; Xie, Yanqiong; Xu, Xiaojun

    2015-01-01

    In this investigation, we first present a statistical result of the interplanetary sources of very strong solar wind dynamic pressure pulses (DPPs) detected by WIND during solar cycle 23. It is found that the vast majority of strong DPPs reside within solar wind disturbances. Although the variabilities of geosynchronous magnetic fields (GMFs) due to the impact of positive DPPs have been well established, there appears to be no systematic investigations on the response of GMFs to negative DPPs. Here, we study both the decompression effects of very strong negative DPPs and the compression from strong positive DPPs on GMFs at different magnetic local time sectors. In response to the decompression of strong negative DPPs, GMFs on the dayside near dawn and near dusk on the nightside, are generally depressed. But near the midnight region, the responses of GMF are very diverse, being either positive or negative. For part of the events when GOES is located at the midnight sector, the GMF is found to abnormally increase as the result of magnetospheric decompression caused by negative DPPs. It is known that under certain conditions magnetic depression of nightside GMFs can be caused by the impact of positive DPPs. Here, we find that a stronger pressure enhancement may have a higher probability of producing the exceptional depression of GMF at the midnight region. Statistically, both the decompression effect of strong negative DPPs and the compression effect of strong positive DPPs depend on the magnetic local time, which are stronger at the noon sector

  9. CSIR Technology Impact 1998

    CSIR Research Space (South Africa)

    CSIR

    1998-01-01

    Full Text Available stream_source_info CSIR Technology Impact 1998.pdf.txt stream_content_type text/plain stream_size 23 Content-Encoding ISO-8859-1 stream_name CSIR Technology Impact 1998.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  10. Ejecta from Ocean Impacts

    Science.gov (United States)

    Kyte, Frank T.

    2003-01-01

    Numerical simulations of deep-ocean impact provide some limits on the size of a projectile that will not mix with the ocean floor during a deep-ocean impact. For a vertical impact at asteroidal velocities (approx. 20 km/s), mixing is only likely when the projectile diameter is greater than 112 of the water depth. For oblique impacts, even larger projectiles will not mix with ocean floor silicates. Given the typical water depths of 4 to 5 km in deep-ocean basins, asteroidal projectiles with diameters as large as 2 or 3 km may commonly produce silicate ejecta that is composed only of meteoritic materials and seawater salts. However, the compressed water column beneath the projectile can still disrupt and shock metamorphose the ocean floor. Therefore, production of a separate, terrestrial ejecta component is not ruled out in the most extreme case. With increasing projectile size (or energy) relative to water depths, there must be a gradation between oceanic impacts and more conventional continental impacts. Given that 60% of the Earth's surface is covered by oceanic lithosphere and 500 m projectiles impact the Earth on 10(exp 5) y timescales, there must be hundreds of oceanic impact deposits in the sediment record awaiting discovery.

  11. Impact studies at Winfrith

    International Nuclear Information System (INIS)

    Cooper, C.A.; Wicks, S.J.

    1987-02-01

    Analytical and experimental studies of subsonic impacts on nuclear reactor plant structures have been in progress at Winfrith since 1977. These studies have examined the behaviour of concrete and metal structures under the impact of missiles typifying those derived either from the plant itself or from external sources, such as crashing aircraft. During 1986 the Winfrith programme was expanded to include studies of the behaviour of radioactive materials transport containers under impact conditions. This report initially describes the experimental facilities available for impact studies at Winfrith. These include both compressed air guns, capable of delivering payloads of up to 65 kg at sonic velocity or payloads up to 2 tonnes at speeds up to 45 ms -1 , and drop test facilities for impact testing of models, up to full-scale radioactive materials transport flasks, at relatively low speeds. Supporting facilities include a small concrete manufacturing laboratory to produce concrete targets. Assessments of the resistance of concrete or metal structures to impact damage are performed using empirical or semi-empirical correlations, derived from data obtained in well-characterised experiments, or using structural dynamics finite element codes. The codes used by the analysts and the computing facilities available for impact analysis work are described. Finally the current programme of impact studies is reviewed, recent progress is summarised and future plans outlined. (author)

  12. Change Agents & Impact Assessment

    DEFF Research Database (Denmark)

    Kørnøv, Lone; Larsen, Sanne Vammen; Hansen, Anne Merrild

    2010-01-01

    One of the challenges facing impact assessment is finding ways to work in research and practice that allow appropriate action and critical interrogation og action to enable and support sustainable change.......One of the challenges facing impact assessment is finding ways to work in research and practice that allow appropriate action and critical interrogation og action to enable and support sustainable change....

  13. Asteroid impact monitoring

    Directory of Open Access Journals (Sweden)

    Milani A.

    2006-01-01

    Full Text Available Some asteroids and comets with Earth-crossing orbit may impact our planet, thus we need to be able to identify the cases which could have a dangerous close approach within a century. This must be done as soon as such an asteroid is discovered, allowing for follow up observations which might contradict the impact possibility, and in the worst case to organize mitigation, possibly including deflection. The mathematical problem of predicting possible impacts, even with very low probabilities, has been solved by our group in the last few years. This paper presents the basic theory of these impact prediction, and discusses how they are practically used in the impact monitoring systems now operational, in particular the CLOMON2 robot of the Universities of Pisa and Valladolid.

  14. Prognostic impact of anticardiolipin antibodies in women with recurrent miscarriage negative for the lupus anticoagulant

    DEFF Research Database (Denmark)

    Nielsen, Henriette Svarre; Christiansen, Ole Bjarne

    2005-01-01

    BACKGROUND: Anticardiolipin antibodies (ACA) are found with increased prevalence in women with unexplained recurrent miscarriage (RM) but their impact on future pregnancy outcome in lupus anticoagulant (LAC) negative patients needs better quantification. METHODS: The impact of a repeatedly positive...... ACA test on the chance of live birth in the next pregnancy after adjustment for relevant prognostic factors was studied in 147 RM patients who had been included in placebo-controlled trials of immunotherapy. Patients with LAC were excluded and none of the patients received therapy with anticoagulation...... OR for live birth among ACA positive patients was 0.48 (95% CI 0.2-1.1, P = 0.10). Positivity for IgM ACA was found to be much stronger correlated to pregnancy outcome than IgG ACA. CONCLUSIONS: In RM women not receiving anticoagulation or prednisone, the presence of ACA in the absence of LAC most likely...

  15. The impact of kinetic effects on the properties of relativistic electron–positron shocks

    International Nuclear Information System (INIS)

    Stockem, Anne; Fiúza, Frederico; Fonseca, Ricardo A; Silva, Luis O

    2012-01-01

    We assess the impact of non-thermally shock-accelerated particles on the magnetohydrodynamic (MHD) jump conditions of relativistic shocks. The adiabatic constant is calculated directly from first-principles particle-in-cell simulation data, enabling a semi-kinetic approach to improve the standard fluid model and allowing for an identification of the key parameters that define the shock structure. We find that the evolving upstream parameters have a stronger impact than the corrections due to non-thermal particles. We find that the decrease in the upstream bulk speed result in deviations from the standard MHD model up to 10%. Furthermore, we obtain a quantitative definition of the shock transition region from our analysis. For Weibel-mediated shocks the inclusion of a magnetic field in the MHD conservation equations is addressed for the first time. (paper)

  16. Evaluating the impact of healthy cities in Europe

    Directory of Open Access Journals (Sweden)

    Geoff Green

    2007-12-01

    Full Text Available

    Background: Cities are engines of health development and not merely settings for health promotion. However, political scientists contest the extent of their powers and the scope of their influence.

    Methodology: Assuming local governance is a locus of decision-making about intermediate determinants of health, then there are three methodological challenges to evaluating its impact: first, accounting for context; second, addressing multiple, interactive interventions; and third identifying mechanisms for change. ‘Realist’ evaluation is more appropriate for this task than traditional paradigms of public health research.

    Review: Commissioned evaluations of the first three phases (1987-2002 of the WHO European Healthy Cities Network are reviewed against the three methodological challenges.

    Conclusions: These evaluations are stronger in identifying necessary city structures and processes but weaker, as are the Network cities themselves, in identifying change mechanisms which convert sector interventions into health gains. This lacuna is addressed in Phase IV (2003-2008 of the Network by the themes of healthy urban planning and health impact assessment.

  17. Localized structural frustration for evaluating the impact of sequence variants.

    Science.gov (United States)

    Kumar, Sushant; Clarke, Declan; Gerstein, Mark

    2016-12-01

    Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype-genotype associations. Protein structures provide a way of addressing this challenge. Previous efforts have focused on globally quantifying the impact of SNVs on protein stability. However, local perturbations may severely impact protein functionality without strongly disrupting global stability (e.g. in relation to catalysis or allostery). Here, we describe a workflow in which localized frustration, quantifying unfavorable local interactions, is employed as a metric to investigate such effects. Using this workflow on the Protein Databank, we find that frustration produces many immediately intuitive results: for instance, disease-related SNVs create stronger changes in localized frustration than non-disease related variants, and rare SNVs tend to disrupt local interactions to a larger extent than common variants. Less obviously, we observe that somatic SNVs associated with oncogenes and tumor suppressor genes (TSGs) induce very different changes in frustration. In particular, those associated with TSGs change the frustration more in the core than the surface (by introducing loss-of-function events), whereas those associated with oncogenes manifest the opposite pattern, creating gain-of-function events. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  18. Acute Health Impact of Air Pollution in China

    Science.gov (United States)

    Feng, T.; Zhao, Y.; Zheng, M.

    2014-12-01

    Air pollution not only has long term health impact, but can affect health through acute exposure. This paper, using air pollution index (API) as overall evaluation of air quality, blood pressure and vital capacity as health outcomes, focuses on the acute health impact of air pollution in China. Current result suggests that after controlling smoking history, occupational exposure, income and education, API is positively associated with blood pressure and negatively associated with vital capacity. The associations became stronger for people with hypertension or pulmonary functional diseases, which indicates that these people are more sensitive to air pollution. Among three pollutants which API measures, that is inhalable particles (PM10), sulfur dioxide (SO2) and nitrogen dioxide (NO2), PM10 is most statistically associated with blood pressure increase and vital capacity decrease. Further study will focusing on the following two questions. The first question is how various time lags affect the associations among API, blood pressure and vital capacity. The second question is how differently people in various cohorts reacts to acute exposure to air pollution. The differences in reactions of blood pressure and vital capacity between people in urban and rural areas, genders, various age cohorts, distinct income and education groups will be further studied.

  19. Localized structural frustration for evaluating the impact of sequence variants

    Science.gov (United States)

    Kumar, Sushant; Clarke, Declan; Gerstein, Mark

    2016-01-01

    Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype–genotype associations. Protein structures provide a way of addressing this challenge. Previous efforts have focused on globally quantifying the impact of SNVs on protein stability. However, local perturbations may severely impact protein functionality without strongly disrupting global stability (e.g. in relation to catalysis or allostery). Here, we describe a workflow in which localized frustration, quantifying unfavorable local interactions, is employed as a metric to investigate such effects. Using this workflow on the Protein Databank, we find that frustration produces many immediately intuitive results: for instance, disease-related SNVs create stronger changes in localized frustration than non-disease related variants, and rare SNVs tend to disrupt local interactions to a larger extent than common variants. Less obviously, we observe that somatic SNVs associated with oncogenes and tumor suppressor genes (TSGs) induce very different changes in frustration. In particular, those associated with TSGs change the frustration more in the core than the surface (by introducing loss-of-function events), whereas those associated with oncogenes manifest the opposite pattern, creating gain-of-function events. PMID:27915290

  20. Social impact assessments: Developing a consolidated conceptual framework

    International Nuclear Information System (INIS)

    Arce-Gomez, Antonio; Donovan, Jerome D.; Bedggood, Rowan E.

    2015-01-01

    Social Impact Assessments (SIAs) have played an increasingly important role in the conduct of planned interventions, providing proponents the capacity to assess and manage the social consequences of their activities. Whilst the SIA field has experienced significant conceptual and practical development over the last decade, efforts at consolidating this within one framework have been limited. In this paper, we incorporate this new knowledge by redeveloping and thus updating the SIA procedural framework developed by Interorganizational Committee on Guidelines and Principles for Social Impact Assessment. In doing so, this updated procedural framework has attempted to incorporate current ‘best practice’ that focuses on participatory approaches to undertaking an SIA. This involved making adaptions to two steps, expansions to five steps, integration of a stronger participatory approach to six steps, and the development of a new step, Management and Evaluation reflecting moves towards ex-post use of SIA processes. It is hoped that this consolidation of the literature of a decade's worth of key findings in SIA research will lead to further efforts towards a meta-evaluation of SIA literature and a platform from which newer developments may be further investigated

  1. Impact and attrition shear breakage of enzyme granules and placebo particles-application to particle design and formulation

    DEFF Research Database (Denmark)

    Jørgensen, Kåre; Bach, Poul; Jensen, Anker

    2005-01-01

    the enzyme into the core of the granule as compared to a layer-structured enzyme distribution. Furthermore, the results indicated that stronger enzyme granule core materials provide a better impact resistance of the final enzyme granule towards the release of enzyme-active dust. Coating layers of inorganic...... salts and water-soluble polymers are observed to enhance the breakage resistance of the enzyme granules tremendously. The impact and shear resistance of four different placebo enzyme granule core particles were investigated. A transition from chipping to fragmentation as the main breakage mechanism...... was observed at impact velocities from 8 to 20 m/s. Experiments performed with attrition shearing indicated that the extent of breakage depend on surface friction and particle sphericity as well as intraparticular forces. The results obtained in this work are of importance for the design and formulation...

  2. Impact of granular drops

    KAUST Repository

    Marston, J. O.

    2013-07-15

    We investigate the spreading and splashing of granular drops during impact with a solid target. The granular drops are formed from roughly spherical balls of sand mixed with water, which is used as a binder to hold the ball together during free-fall. We measure the instantaneous spread diameter for different impact speeds and find that the normalized spread diameter d/D grows as (tV/D)1/2. The speeds of the grains ejected during the “splash” are measured and they rarely exceed twice that of the impact speed.

  3. The Impact of Empathy

    DEFF Research Database (Denmark)

    Jensen, Didde; Pedersen, Line Bjørnskov

    2017-01-01

    This article investigates whether the empathic abilities of street-level bureaucrats have an impact on their discretionary decision-making. The impact of empathic abilities on decision-making is considered an important research question, as our knowledge remains limited as to the importance...... in correctional facilities in Denmark, with a 67.5% response rate. The findings confirm that discretionary decision-making is affected by the empathic abilities of bureaucrats. However, the impact of empathy depends on the severity of inmates' infringement against the rules. In essence, the findings demonstrate...

  4. Impact damage of composites

    Science.gov (United States)

    Wu, Hsi-Young T.; Springer, George S.

    1986-01-01

    A model is described for estimating the impact damage of fiber reinforced composite plates. The displacements and stresses are calculated by a three dimensional transient, finite element method of solution of the governing equations applicable to a linearly elastic body. The region in which damage occurs is estimated using the Tsai-Wu failure criterion. A computer code was developed which can be used to calculate the impact force, displacements and velocities of the plate and the impact body, stresses and strains in the plate, and the damage area. Sample numerical results are presented illustrating the type of information provided by the code. Comparisons between measured and calculated damage areas are also given.

  5. Environmental impact report (draft)

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    The three projects as proposed by Pacific Gas and Electric Company and the environmental analysis of the projects are discussed. Sections on the natural and social environments of the proposed projects and their surrounding areas consist of descriptions of the setting, discussions of the adverse and beneficial consequences of the project, and potential mitigation measures to reduce the effects of adverse impacts. The Environmental Impact Report includes discussions of unavoidable adverse effects, irreversible changes, long-term and cumulative impacts, growth-inducing effects, and feasible alternatives to the project. (MHR)

  6. Weather Impact on Airport Arrival Meter Fix Throughput

    Science.gov (United States)

    Wang, Yao

    2017-01-01

    Time-based flow management provides arrival aircraft schedules based on arrival airport conditions, airport capacity, required spacing, and weather conditions. In order to meet a scheduled time at which arrival aircraft can cross an airport arrival meter fix prior to entering the airport terminal airspace, air traffic controllers make regulations on air traffic. Severe weather may create an airport arrival bottleneck if one or more of airport arrival meter fixes are partially or completely blocked by the weather and the arrival demand has not been reduced accordingly. Under these conditions, aircraft are frequently being put in holding patterns until they can be rerouted. A model that predicts the weather impacted meter fix throughput may help air traffic controllers direct arrival flows into the airport more efficiently, minimizing arrival meter fix congestion. This paper presents an analysis of air traffic flows across arrival meter fixes at the Newark Liberty International Airport (EWR). Several scenarios of weather impacted EWR arrival fix flows are described. Furthermore, multiple linear regression and regression tree ensemble learning approaches for translating multiple sector Weather Impacted Traffic Indexes (WITI) to EWR arrival meter fix throughputs are examined. These weather translation models are developed and validated using the EWR arrival flight and weather data for the period of April-September in 2014. This study also compares the performance of the regression tree ensemble with traditional multiple linear regression models for estimating the weather impacted throughputs at each of the EWR arrival meter fixes. For all meter fixes investigated, the results from the regression tree ensemble weather translation models show a stronger correlation between model outputs and observed meter fix throughputs than that produced from multiple linear regression method.

  7. Community impact management

    International Nuclear Information System (INIS)

    Baril, R.G.

    1983-01-01

    Industrial expansion, whether for resource extraction, refining, production or distribution and particularly the construction of energy facilities, usually has many effects on communities. In the early 1970s, as more experience was gained with large projects and as communities became more sensitive to their needs and rights, the negative effects of projects gained some prominence. Communities questioned whether it was in their best interest to accept changes that large corporations would impose on them. It is in this context that Ontario Hydro, in 1977, set up the first of four community impact agreements for the construction of generating stations. This paper discusses these community impact agreements and how they have become the framework for the management of community impacts. Also, the paper discusses a model for compensating social impacts

  8. Weather Radar Impact Zones

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent an inventory of the national impacts of wind turbine interference with NEXRAD radar stations. This inventory was developed by the NOAA Radar...

  9. Electric vehicle energy impacts.

    Science.gov (United States)

    2017-05-01

    The objective of this research project was to evaluate the impacts of electric vehicles (EVs) and : renewable wind and solar photovoltaic (PV) power generation on reducing petroleum imports : and greenhouse gas emissions to Hawaii. In 2015, the state...

  10. CSIR Technology Impact 1996

    CSIR Research Space (South Africa)

    CSIR

    1996-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review by highlighting a number of innovative projects and initiatives in these areas. It presents a rich canvas portrays technology solutions...

  11. Laboratory Impact Experiments

    Science.gov (United States)

    Horanyi, M.; Munsat, T.

    2017-12-01

    The experimental and theoretical programs at the SSERVI Institute for Modeling Plasmas, Atmospheres, and Cosmic Dust (IMPACT) address the effects of hypervelocity dust impacts and the nature of the space environment of granular surfaces interacting with solar wind plasma and ultraviolet radiation. These are recognized as fundamental planetary processes due their role in shaping the surfaces of airless planetary objects, their plasma environments, maintaining dust haloes, and sustaining surface bound exospheres. Dust impacts are critically important for all airless bodies considered for possible human missions in the next decade: the Moon, Near Earth Asteroids (NEAs), Phobos, and Deimos, with direct relevance to crew and mission safety and our ability to explore these objects. This talk will describe our newly developed laboratory capabilities to assess the effects of hypervelocity dust impacts on: 1) the gardening and redistribution of dust particles; and 2) the generation of ionized and neutral gasses on the surfaces of airless planetary bodies.

  12. CSIR Technology Impact 2002

    CSIR Research Space (South Africa)

    CSIR

    2002-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review (1 March 2001 - 28 February 2002) by highlighting a number of innovative projects and initiatives in these areas....

  13. Impact Management System

    Data.gov (United States)

    US Agency for International Development — IMS (developed w/Iraq mission) is a system for conducting quality portfolio impact analysis, linking projects to strategy through integration of context data. IMS...

  14. CSIR Technology Impact 1994

    CSIR Research Space (South Africa)

    CSIR

    1994-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review by highlighting a number of innovative projects and initiatives in these areas. It presents a rich canvas portrays technology solutions...

  15. Atmosphere Impact Losses

    Science.gov (United States)

    Schlichting, Hilke E.; Mukhopadhyay, Sujoy

    2018-02-01

    Determining the origin of volatiles on terrestrial planets and quantifying atmospheric loss during planet formation is crucial for understanding the history and evolution of planetary atmospheres. Using geochemical observations of noble gases and major volatiles we determine what the present day inventory of volatiles tells us about the sources, the accretion process and the early differentiation of the Earth. We further quantify the key volatile loss mechanisms and the atmospheric loss history during Earth's formation. Volatiles were accreted throughout the Earth's formation, but Earth's early accretion history was volatile poor. Although nebular Ne and possible H in the deep mantle might be a fingerprint of this early accretion, most of the mantle does not remember this signature implying that volatile loss occurred during accretion. Present day geochemistry of volatiles shows no evidence of hydrodynamic escape as the isotopic compositions of most volatiles are chondritic. This suggests that atmospheric loss generated by impacts played a major role during Earth's formation. While many of the volatiles have chondritic isotopic ratios, their relative abundances are certainly not chondritic again suggesting volatile loss tied to impacts. Geochemical evidence of atmospheric loss comes from the {}3He/{}^{22}Ne, halogen ratios (e.g., F/Cl) and low H/N ratios. In addition, the geochemical ratios indicate that most of the water could have been delivered prior to the Moon forming impact and that the Moon forming impact did not drive off the ocean. Given the importance of impacts in determining the volatile budget of the Earth we examine the contributions to atmospheric loss from both small and large impacts. We find that atmospheric mass loss due to impacts can be characterized into three different regimes: 1) Giant Impacts, that create a strong shock transversing the whole planet and that can lead to atmospheric loss globally. 2) Large enough impactors (m_{cap} ≳ √{2

  16. Economic impacts study

    Energy Technology Data Exchange (ETDEWEB)

    Brunsen, W.; Worley, W.; Frost, E.

    1988-09-30

    This is a progress report on the first phase of a project to measure the economic impacts of a rapidly changing U.S. target base. The purpose of the first phase is to designate and test the macroeconomic impact analysis model. Criteria were established for a decision-support model. Additional criteria were defined for an interactive macroeconomic impact analysis model. After a review of several models, the Economic Impact Forecast System model of the U.S. Army Construction Research Laboratory was selected as the appropriate input-output tool that can address local and regional economic analysis. The model was applied to five test cases to demonstrate its utility and define possible revisions to meet project criteria. A plan for EIFS access was defined at three levels. Objectives and tasks for scenario refinement are proposed.

  17. CSIR Technology Impact 2003

    CSIR Research Space (South Africa)

    CSIR

    2003-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review (1 March 2002 - 28 February 2003) by highlighting a number of innovative projects and initiatives in various CSIR business units....

  18. CSIR Technology Impact 1993

    CSIR Research Space (South Africa)

    CSIR

    1993-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review by highlighting a number of innovative projects and initiatives in these areas. It presents a rich canvas portrays technology solutions...

  19. CSIR Technology Impact 2000

    CSIR Research Space (South Africa)

    CSIR

    2000-01-01

    Full Text Available This millennium issue of Technology Impact celebrates the CSIR's contributions during the transitional 1999/2000 year. It presents a rich canvas portrays technology solutions and information which have touched the lives of people both within...

  20. CSIR Technology Impact 1999

    CSIR Research Space (South Africa)

    CSIR

    1999-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review by highlighting a number of innovative projects and initiatives in these areas. It presents a rich canvas portrays technology solutions...

  1. Quality Measurement Impact Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Secretary of the Department of Health and Human Services is required to assess the impact of consensus-endorsed quality and efficiency measures used in federal...

  2. Earthquake impact scale

    Science.gov (United States)

    Wald, D.J.; Jaiswal, K.S.; Marano, K.D.; Bausch, D.

    2011-01-01

    With the advent of the USGS prompt assessment of global earthquakes for response (PAGER) system, which rapidly assesses earthquake impacts, U.S. and international earthquake responders are reconsidering their automatic alert and activation levels and response procedures. To help facilitate rapid and appropriate earthquake response, an Earthquake Impact Scale (EIS) is proposed on the basis of two complementary criteria. On the basis of the estimated cost of damage, one is most suitable for domestic events; the other, on the basis of estimated ranges of fatalities, is generally more appropriate for global events, particularly in developing countries. Simple thresholds, derived from the systematic analysis of past earthquake impact and associated response levels, are quite effective in communicating predicted impact and response needed after an event through alerts of green (little or no impact), yellow (regional impact and response), orange (national-scale impact and response), and red (international response). Corresponding fatality thresholds for yellow, orange, and red alert levels are 1, 100, and 1,000, respectively. For damage impact, yellow, orange, and red thresholds are triggered by estimated losses reaching $1M, $100M, and $1B, respectively. The rationale for a dual approach to earthquake alerting stems from the recognition that relatively high fatalities, injuries, and homelessness predominate in countries in which local building practices typically lend themselves to high collapse and casualty rates, and these impacts lend to prioritization for international response. In contrast, financial and overall societal impacts often trigger the level of response in regions or countries in which prevalent earthquake resistant construction practices greatly reduce building collapse and resulting fatalities. Any newly devised alert, whether economic- or casualty-based, should be intuitive and consistent with established lexicons and procedures. Useful alerts should

  3. Spin transport at the international linear collider and its impact on the measurement of polarization

    Energy Technology Data Exchange (ETDEWEB)

    Beckmann, Moritz

    2013-12-15

    At the planned International Linear Collider (ILC), the longitudinal beam polarization needs to be determined with an unprecedented precision. For that purpose, the beam delivery systems (BDS) are equipped with two laser Compton polarimeters each, which are foreseen to achieve a systematic uncertainty of {<=} 0.25 %. The polarimeters are located 1.6 km upstream and 150 m downstream of the e{sup +}e{sup -} interaction point (IP). The average luminosity-weighted longitudinal polarization P{sup lumi}{sub z}, which is the decisive quantity for the experiments, has to be determined from these measurements with the best possible precision. Therefore, a detailed understanding of the spin transport in the BDS is mandatory to estimate how precise the longitudinal polarization at the IP is known from the polarimeter measurements. The envisaged precision for the propagation of the measurement value is {<=} 0.1 %. This thesis scrutinizes the spin transport in view of the achievable precision. A detailed beamline simulation for the BDS has been developed, including the simulation of the beam-beam collisions at the IP. The following factors which might limit the achievable precision is investigated: a variation of the beam parameters, the beam alignment precision at the polarimeters and the IP, the bunch rotation at the IP, the detector magnets, the beam-beam collisions, the emission of synchrotron radiation and misalignments of the beamline elements. In absence of collisions, a precision of 0.085% on the propagation of the measured longitudinal polarization has been found achievable. This result however depends mainly on the presumed precisions for the parallel alignment of the beam at the polarimeters and for the alignment of polarization vector. In presence of collisions, the measurement at the downstream polarimeter depends strongly on the intensity of the collision and the size of the polarimeter laser spot. Therefore, a more detailed study of the laser-bunch interaction is

  4. Semiconductor projectile impact detector

    Science.gov (United States)

    Shriver, E. L. (Inventor)

    1977-01-01

    A semiconductor projectile impact detector is described for use in determining micrometeorite presence, as well as its flux and energy comprising a photovoltaic cell which generates a voltage according to the light and heat emitted by the micrometeorites upon impact. A counter and peak amplitude measuring device were used to indicate the number of particules which strike the surface of the cell as well as the kinetic energy of each of the particles.

  5. Impact factor distribution revisited

    Science.gov (United States)

    Huang, Ding-wei

    2017-09-01

    We explore the consistency of a new type of frequency distribution, where the corresponding rank distribution is Lavalette distribution. Empirical data of journal impact factors can be well described. This distribution is distinct from Poisson distribution and negative binomial distribution, which were suggested by previous study. By a log transformation, we obtain a bell-shaped distribution, which is then compared to Gaussian and catenary curves. Possible mechanisms behind the shape of impact factor distribution are suggested.

  6. Fracture Behavior under Impact.

    Science.gov (United States)

    1983-01-01

    value still is ." the Charpy energy, i.e. the energy to break a Charpy V-notch specimen in a pendulum type impact tester. This material property...Most of the dynamic fracture toughness 3ata have been obtained in the lower impact velocity range with Charpy - and drop weight tests. An overview of...A .-..- ..- -6- =.., lyses (e.g. with Charpy tests [3]), theoretical analyses which some- times are based on nonrealistic assumptions (e.g. infinite

  7. Study of the global and regional climatic impacts of ENSO magnitude using SPEEDY AGCM

    KAUST Repository

    Dogar, Muhammad Mubashar

    2017-03-09

    ENSO is considered as a strong atmospheric teleconnection that has pronounced global and regional circulation effects. It modifies global monsoon system, especially, Asian and African monsoons. Previous studies suggest that both the frequency and magnitude of ENSO events have increased over the last few decades resulting in a need to study climatic impacts of ENSO magnitude both at global and regional scales. Hence, to better understand the impact of ENSO amplitude over the tropical and extratropical regions focussing on the Asian and African domains, ENSO sensitivity experiments are conducted using ICTPAGCM (‘SPEEDY’). It is anticipated that the tropical Pacific SST forcing will be enough to produce ENSO-induced teleconnection patterns; therefore, the model is forced using NINO3.4 regressed SST anomalies over the tropical Pacific only. SPEEDY reproduces the impact of ENSO over the Pacific, North and South America and African regions very well. However, it underestimates ENSO teleconnection patterns and associated changes over South Asia, particularly in the Indian region, which suggests that the tropical Pacific SST forcing is not sufficient to represent ENSO-induced teleconnection patterns over South Asia. Therefore, SST forcing over the tropical Indian Ocean together with air–sea coupling is also required for better representation of ENSO-induced changes in these regions. Moreover, results obtained by this pacemaker experiment show that ENSO impacts are relatively stronger over the Inter-Tropical Convergence Zone (ITCZ) compared to extratropics and high latitude regions. The positive phase of ENSO causes weakening in rainfall activity over African tropical rain belt, parts of South and Southeast Asia, whereas, the La Niña phase produces more rain over these regions during the summer season. Model results further reveal that ENSO magnitude has a stronger impact over African Sahel and South Asia, especially over the Indian region because of its significant

  8. Health impacts of floods.

    Science.gov (United States)

    Du, Weiwei; FitzGerald, Gerard Joseph; Clark, Michele; Hou, Xiang-Yu

    2010-01-01

    Floods are the most common hazard to cause disasters and have led to extensive morbidity and mortality throughout the world. The impact of floods on the human community is related directly to the location and topography of the area, as well as human demographics and characteristics of the built environment. The aim of this study is to identify the health impacts of disasters and the underlying causes of health impacts associated with floods. A conceptual framework is developed that may assist with the development of a rational and comprehensive approach to prevention, mitigation, and management. This study involved an extensive literature review that located >500 references, which were analyzed to identify common themes, findings, and expert views. The findings then were distilled into common themes. The health impacts of floods are wide ranging, and depend on a number of factors. However, the health impacts of a particular flood are specific to the particular context. The immediate health impacts of floods include drowning, injuries, hypothermia, and animal bites. Health risks also are associated with the evacuation of patients, loss of health workers, and loss of health infrastructure including essential drugs and supplies. In the medium-term, infected wounds, complications of injury, poisoning, poor mental health, communicable diseases, and starvation are indirect effects of flooding. In the long-term, chronic disease, disability, poor mental health, and poverty-related diseases including malnutrition are the potential legacy. This article proposes a structured approach to the classification of the health impacts of floods and a conceptual framework that demonstrates the relationships between floods and the direct and indirect health consequences.

  9. Centrifuge impact cratering experiment 5

    Science.gov (United States)

    1984-01-01

    Transient crates motions, cratering flow fields, crates dynamics, determining impact conditions from total crater welt, centrifuge quarter-space cratering, and impact cratering mechanics research is documented.

  10. Environmental impact assessment of NPP decommissioning

    International Nuclear Information System (INIS)

    Hinca, R.

    2009-01-01

    In this presentation the following potential impacts of decommissioning of NPP are discussed: - Impacts on population; Impacts on natural environment; Land impacts; Impacts on urban complex and land utilisation; Possible impacts on area as a result of failure.

  11. The Asteroid Impact Mission

    Science.gov (United States)

    Carnelli, Ian; Galvez, Andres; Mellab, Karim

    2016-04-01

    The Asteroid Impact Mission (AIM) is a small and innovative mission of opportunity, currently under study at ESA, intending to demonstrate new technologies for future deep-space missions while addressing planetary defense objectives and performing for the first time detailed investigations of a binary asteroid system. It leverages on a unique opportunity provided by asteroid 65803 Didymos, set for an Earth close-encounter in October 2022, to achieve a fast mission return in only two years after launch in October/November 2020. AIM is also ESA's contribution to an international cooperation between ESA and NASA called Asteroid Impact Deflection Assessment (AIDA), consisting of two mission elements: the NASA Double Asteroid Redirection Test (DART) mission and the AIM rendezvous spacecraft. The primary goals of AIDA are to test our ability to perform a spacecraft impact on a near-Earth asteroid and to measure and characterize the deflection caused by the impact. The two mission components of AIDA, DART and AIM, are each independently valuable but when combined they provide a greatly increased scientific return. The DART hypervelocity impact on the secondary asteroid will alter the binary orbit period, which will also be measured by means of lightcurves observations from Earth-based telescopes. AIM instead will perform before and after detailed characterization shedding light on the dependence of the momentum transfer on the asteroid's bulk density, porosity, surface and internal properties. AIM will gather data describing the fragmentation and restructuring processes as well as the ejection of material, and relate them to parameters that can only be available from ground-based observations. Collisional events are of great importance in the formation and evolution of planetary systems, own Solar System and planetary rings. The AIDA scenario will provide a unique opportunity to observe a collision event directly in space, and simultaneously from ground-based optical and

  12. Impact decision support diagrams

    Science.gov (United States)

    Boslough, Mark

    2014-10-01

    One way to frame the job of planetary defense is to “find the optimal approach for finding the optimal approach” to NEO mitigation. This requires a framework for defining in advance what should be done under various circumstances. The two-dimensional action matrix from the recent NRC report “Defending Planet Earth” can be generalized to a notional “Impact Decision Support Diagram” by extending it into a third dimension. The NRC action matrix incorporated two important axes: size and time-to-impact, but probability of impact is also critical (it is part of the definitions of both the Torino and Palermo scales). Uncertainty has been neglected, but is also crucial. It can be incorporated by subsuming it into the NEO size axis by redefining size to be three standard deviations greater than the best estimate, thereby providing a built-in conservative margin. The independent variable is time-to-impact, which is known with high precision. The other two axes are both quantitative assessments of uncertainty and are both time dependent. Thus, the diagram is entirely an expression of uncertainty. The true impact probability is either one or zero, and the true size does not change. The domain contains information about the current uncertainty, which changes with time (as opposed to reality, which does not change).

  13. Quantifying the impact of early 21st century volcanic eruptions on global-mean surface temperature

    Science.gov (United States)

    Monerie, Paul-Arthur; Moine, Marie-Pierre; Terray, Laurent; Valcke, Sophie

    2017-05-01

    Despite a continuous increase in well-mixed greenhouse gases, the global-mean surface temperature has shown a quasi-stabilization since 1998. This muted warming has been linked to the combined effects of internal climate variability and external forcing. The latter includes the impact of recent increase in the volcanic activity and of solar irradiance changes. Here we used a high-resolution coupled ocean-atmosphere climate model to assess the impact of the recent volcanic eruptions on the Earth's temperature, compared with the low volcanic activity of the early 2000s. Two sets of simulations are performed, one with realistic aerosol optical depth values, and the other with a fixed value of aerosol optical depth corresponding to a period of weak volcanic activity (1998-2002). We conclude that the observed recent increase in the volcanic activity led to a reduced warming trend (from 2003 to 2012) of 0.08 °C in ten years. The induced cooling is stronger during the last five-year period (2008-2012), with an annual global mean cooling of 0.04 °C (+/- 0.04 °C). The cooling is similar in summer (0.05 °C +/- 0.04 °C cooling) than in winter (0.03 °C +/- 0.04 °C cooling), but stronger in the Northern Hemisphere than in the Southern Hemisphere. Although equatorial and Arctic precipitation decreases in summer, the change in precipitation does not indicate robust changes at a local scale. Global heat content variations are found not to be impacted by the recent increase in volcanic activity.

  14. From Pressures to Impacts

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky

    2006-01-01

    materials over manufacture or construction through use to disposal or decommissioning and recycling. It is a holistic tool in the sense that it models all relevant environmental impacts from the global (like climate change and ozone depletion) to the local (like land use) and also the loss of resources...... and the background conditions of the receiving environment - the aggregation of emissions over time and space - the fact that the emissions in the inventory represent the impacts from a functional unit, which for products often constitutes a minute fraction of the total output from the manufacturing stage. For waste...... management systems, it is pointed out, that these aspects may be less of a problem than for the typical product systems for which LCA was originally developed, since the environmental impacts from waste management systems are typically dominated by one or a few central waste treatment processes for which...

  15. Ecological impact assessment

    International Nuclear Information System (INIS)

    Thomas, J.M.; Eberhardt, L.L.

    1975-01-01

    Quantitative problems in accomplishing ecological impact assessment with particular reference to defining population effects are discussed with some comments on the two approaches most commonly used, e.g., the experimental and simulation models. Some alternatives are suggested because both methods will probably fail to detect real population effects mostly due to poor understanding of ecosystems or because of the limitations inherent in field census methods. Most judgments of ecological impact are not quantitatively defensible but are qualitative, subjective, or political in nature. An examination of aggregates of data from various nuclear power plant sites may be one way to obtain enough replication to judge ecological impact. Thus, currently available data from such studies as well as appropriate demographic, vegetation, census, and bibliographic material could offer an interesting challenge to computer professionals if such an undertaking were contemplated. Present research programs at PNL and computer involvement are described. Future possibilities and directions are discussed. (U.S.)

  16. Violent breaking wave impacts

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Peregrine, D.H.; Bullock, G.N.

    2009-01-01

    a better understanding of the processes involved. The wave's approach towards a structure is modelled with classical irrotational flow to obtain the different types of impact profiles that may or may not lead to air entrapment. The subsequent impact is modelled with a novel compressible-flow model...... local error. The high pressures measured during wave impacts on a breakwater are reproduced and it is shown that trapped air can be compressed to a pressure of several atmospheres. Pressure shock waves, reflected off nearby surfaces such as the seabed, can lead to pressures comparable with those...... for a homogeneous mixture of incompressible liquid and ideal gas. This enables a numerical description of both trapped air pockets and the propagation of pressure shock waves through the aerated water. An exact Riemann solver is developed to permit a finite-volume solution to the flow model with smallest possible...

  17. Economic impact of refugees.

    Science.gov (United States)

    Taylor, J Edward; Filipski, Mateusz J; Alloush, Mohamad; Gupta, Anubhab; Rojas Valdes, Ruben Irvin; Gonzalez-Estrada, Ernesto

    2016-07-05

    In 2015, the United Nations High Commission for Refugees accommodated over 15 million refugees, mostly in refugee camps in developing countries. The World Food Program provided these refugees with food aid, in cash or in kind. Refugees' impacts on host countries are controversial and little understood. This unique study analyzes the economic impacts of refugees on host-country economies within a 10-km radius of three Congolese refugee camps in Rwanda. Simulations using Monte Carlo methods reveal that cash aid to refugees creates significant positive income spillovers to host-country businesses and households. An additional adult refugee receiving cash aid increases annual real income in the local economy by $205 to $253, significantly more than the $120-$126 in aid each refugee receives. Trade between the local economy and the rest of Rwanda increases by $49 to $55. The impacts are lower for in-kind food aid, a finding relevant to development aid generally.

  18. Phylogenetic and ecological factors impact the gut microbiota of two Neotropical primate species.

    Science.gov (United States)

    Amato, Katherine R; Martinez-Mota, Rodolfo; Righini, Nicoletta; Raguet-Schofield, Melissa; Corcione, Fabiana Paola; Marini, Elisabetta; Humphrey, Greg; Gogul, Grant; Gaffney, James; Lovelace, Elijah; Williams, LaShanda; Luong, Albert; Dominguez-Bello, Maria Gloria; Stumpf, Rebecca M; White, Bryan; Nelson, Karen E; Knight, Rob; Leigh, Steven R

    2016-03-01

    Recent studies suggest that variation in diet across time and space results in changes in the mammalian gut microbiota. This variation may ultimately impact host ecology by altering nutritional status and health. Wild animal populations provide an excellent opportunity for understanding these interactions. However, compared to clinical studies, microbial research targeting wild animals is currently limited, and many published studies focus only on a single population of a single host species. In this study we utilize fecal samples from two species of howler monkey (Alouatta pigra and A. palliata) collected at four sites to investigate factors influencing the gut microbiota at three scales: taxonomic (host species), ecosystemic (forest type), and local (habitat disturbance/season). The results demonstrate that the effect of host species on the gut microbiota is stronger than the effect of host forest type, which is stronger than the effect of habitat disturbance or seasonality. Nevertheless, within host species, gut microbiota composition differs in response to forest type, habitat disturbance, and season. Variations in the effect size of these factors are associated both with host species and environment. This information may be beneficial for understanding ecological and evolutionary questions associated with Mesoamerican howler monkeys, as well as determining conservation challenges facing each species. These mechanisms may also provide insight into the ecology of other species of howler monkeys, non-human primates, and mammals.

  19. Maternal acculturation: could it impact oral health practices of mexican-american mothers and their children?

    Science.gov (United States)

    Farokhi, Moshtagh R; Cano, Stephanie M; Bober-Moken, Irene G; Bartoloni, Joseph A; Cunningham, Sue E D; Baez, Martha X

    2011-04-01

    A mother's cultural beliefs can affect her infant's health, but the influence of acculturation of Mexican-American women on their young children's oral health is unknown. The authors hypothesized that maternal acculturation impacts very young children's oral health practices favoring, in particular, the mothers who are more Anglo-oriented. A convenience sample of 204 predominantly Mexican-American women attending the Women, Infants, and Children Clinic in San Antonio, Texas, completed the Knowledge, Attitudes, Beliefs, Social Support, and Self-Efficacy of Oral Health (KASE-OH) and Acculturation Questionnaires. Results indicated that mothers with strong Anglo orientation were more likely educated in the United States, first visited a dentist while in elementary school, and breast-fed their children. Children belonging to Anglo-oriented Mexican-American mothers had stronger oral health practices, were more likely to breast-feed, were exposed to more sugary and acidic drinks, consumed higher levels of candy, had Medicaid coverage, and had stronger supervisions of tooth brushing practices.

  20. The impact of individual variations in taste sensitivity on coffee perceptions and preferences.

    Science.gov (United States)

    Masi, Camilla; Dinnella, Caterina; Monteleone, Erminio; Prescott, John

    2015-01-01

    Despite a few relationships between fungiform papillae (FP) density and 6-n-propylthiouracil (PROP) taster status have been reported for sensory qualities within foods, the impact on preferences remains relatively unclear. The present study investigated responses of FP number and PROP taster groups to different bitter compounds and how these affect coffee perception, consumption and liking. Subjects (Ss) with higher FP numbers (HFP) gave higher liking ratings to coffee samples than those with lower FP numbers (LFP), but only for sweetened coffee. Moreover, HFP Ss added more sugar to the samples than LFP Ss. Significant differences between FP groups were also found for the sourness of the coffee samples, but not for bitterness and astringency. However, HFP Ss rated bitter taste stimuli as stronger than did LFP Ss. While coffee liking was unrelated to PROP status, PROP non-tasters (NTs) added more sugar to the coffee samples than did super-tasters (STs). In addition, STs rated sourness, bitterness and astringency as stronger than NTs, both in coffee and standard solutions. These results confirm that FP density and PROP status play a significant role in taste sensitivity for bitter compounds in general and also demonstrate that sugar use is partly a function of fundamental individual differences in physiology. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Network analysis reveals strongly localized impacts of El Niño

    Science.gov (United States)

    Fan, Jingfang; Meng, Jun; Ashkenazy, Yosef; Havlin, Shlomo; Schellnhuber, Hans Joachim

    2017-07-01

    Climatic conditions influence the culture and economy of societies and the performance of economies. Specifically, El Niño as an extreme climate event is known to have notable effects on health, agriculture, industry, and conflict. Here, we construct directed and weighted climate networks based on near-surface air temperature to investigate the global impacts of El Niño and La Niña. We find that regions that are characterized by higher positive/negative network “in”-weighted links are exhibiting stronger correlations with the El Niño basin and are warmer/cooler during El Niño/La Niña periods. In contrast to non-El Niño periods, these stronger in-weighted activities are found to be concentrated in very localized areas, whereas a large fraction of the globe is not influenced by the events. The regions of localized activity vary from one El Niño (La Niña) event to another; still, some El Niño (La Niña) events are more similar to each other. We quantify this similarity using network community structure. The results and methodology reported here may be used to improve the understanding and prediction of El Niño/La Niña events and also may be applied in the investigation of other climate variables.

  2. Impact Through Trust

    DEFF Research Database (Denmark)

    Mayoral, Juan A.

    This chapter gives an original response to one of the central questions asked in this book: to what extent does the Court of Justice of the European Union (CJEU) impact domestic political and legal systems and what are its implications? More specifically, how might the CJEU increase the impact...... of its rulings and legal mandates in national judiciaries and legal systems? This question is crucial if we understand that national courts are the key decentralised enforcers of the European Union (EU) law responsible for ensuring the effectiveness of EU law and the rulings and mandates imposed...

  3. Second Impact Syndrome.

    Science.gov (United States)

    Cantu, Robert C; Voy, Robert

    1995-06-01

    In brief The known risk of second impact syndrome (SIS) in football has elevated the importance of postconcussion and precompetition exams of injured football players. Six case reports demonstrate that the same mechanism of injury-minor head trauma in a player who still has symptoms from a previous concussion-can cause second impact syndrome in any contact sport. It is important to monitor postconcussion symptoms, which include headache, light-headedness, and impaired consciousness. Return-to-play guidelines for football and boxing provide a basis for making safe activity recommendations for other sports.

  4. Climate change - the impacts

    International Nuclear Information System (INIS)

    Reysset, Bertrand; Billes-Garabedian, Laurent; Henique, Julien; Pascal, Mathilde; Pirard, Philippe; Motreff, Yvon; Barbault, Robert; Weber, Jacques; Gate, Philippe; Salagnac, Jean-Luc; Desplat, Julien; Kounkou-Arnaud, Raphaelle

    2012-01-01

    This special dossier about the impacts of climate change is made of 6 contributions dealing with: the mitigation of climate effects and how to deal with them (Bertrand Reysset); how to dare and transmit (Laurent Billes-Garabedian); littoral risks, the Pas-de-Calais example (Julien Henique); extreme meteorological events and health impacts (Mathilde Pascal, Philippe Pirard, Yvon Motreff); Biodiversity and climate: the janus of global change (Robert Barbault, Jacques Weber); adapting agriculture to dryness and temperatures (Philippe Gate); Paris and the future heats of the year 2100 (Jean-Luc Salagnac, Julien Desplat, Raphaelle Kounkou-Arnaud)

  5. Conflicts and social impacts

    DEFF Research Database (Denmark)

    Larsen, Sanne Vammen; Hansen, Anne Merrild; Nielsen, Helle

    2017-01-01

    of such conflicts, and the role social impacts play. The paper analyses in depth four cases of renewable energy projects, utilizing a conceptualization of conflict constituted by three elements: Attitude, behavior and contradictions. Through analysis of EIA reports and hearing responses as well as interviews......, the paper digs deeper to nuance what constitutes the conflicts and what role social impacts play.......The transition to renewable energy is currently in many places challenged by conflicts over specific projects. For example siting of onshore wind turbines often causes conflicts with local communities, sometimes leading to abandonment of the project or plan. This paper presents an analysis...

  6. The Impact Hazard

    Science.gov (United States)

    Morrison, David

    1994-01-01

    The Earth has been subject to hypervelocity impacts from comets and asteroids since its formation, and such impacts have played an important role in the evolution of life on our planet. We now recognize not only the historical role of impacts, but the contemporary hazard posed by such events. In the absence of a complete census of potentially threatening Earth-crossing asteroids or comets (called collectively Near Earth Objects, or NEOs), or even of a comprehensive cur-rent search program to identify NEOs, we can consider the hazard only from a probabilistic perspective. We know the steep power-law relationship between NEO numbers and size, with many more small bodies than large ones. We also know that few objects less than about 50 m in diameter (with kinetic energy near 10 megatons) penetrate the atmosphere and are capable of doing surface damage. But there is a spectrum of possible impact hazards associated with objects from this 10-megaton threshold all the way up to NEOs 5 km or larger in diameter, which are capable of inflicting severe damage on the environment, leading to mass extinction's of species. Detailed analysis has shown that, in general, the larger the object the greater the hazard, even when allowance is made for the infrequency of large impacts. Most of the danger to human life is associated with impacts by objects roughly 2 km or larger (energy greater than 1 million megatons), which can inject sufficient submicrometer dust into the atmosphere to produce a severe short-term global cooling with subsequent loss of crops, leading to starvation. Hazard estimates suggest that the chance of such an event occurring during a human lifetime is about 1:5000, and the global probability of death from such impacts is of the order of 1:20000, values that can be compared with risks associated with other natural hazards such as earthquakes, volcanic eruptions, and severe storms. However, the impact hazard differs from the others in that it can be largely

  7. Impact of energy efficiency interventions in public housing buildings on cold-related mortality: a case-crossover analysis.

    Science.gov (United States)

    Peralta, Andrés; Camprubí, Lluís; Rodríguez-Sanz, Maica; Basagaña, Xavier; Borrell, Carme; Marí-Dell'Olmo, Marc

    2017-08-01

    Interventions to mitigate fuel poverty and particularly energy efficiency façade retrofitting (EEFR) have demonstrated positive impacts on health but the impacts of EEFR interventions on cold-related mortality have not been studied in depth. We evaluated the impact of EEFR interventions in Barcelona on the association between cold outdoor temperatures and mortality (from all natural causes and from neoplasms, circulatory system and respiratory system causes) from 1986 to 2012. A time-stratified case-crossover analysis was used. Relative risks (RR) for death related to extreme cold (lowest fifth percentile) in the no-intervention and intervention groups were obtained for temperature lag windows covering the day of the death and the previous 20 days (0-2, 3-5, 6-8, 9-11, 12-14, 15-17, 18-20). The statistical significance of the observed changes was evaluated using the RR for the cold temperature-intervention interaction. In men, interventions significantly increased the extreme cold-death association for the lag window 15-17 [interaction RR 2.23, 95% confidence interval (CI) 1.14-4.36]. The impacts were stronger for respiratory system causes and in men aged 75 or older. In women, on lag window 0-2, the extreme cold-death association was not significantly reduced when analysing all natural causes of death (interaction RR 0.46, 95% CI 0.21-1.01), but it was reduced significantly when analysing only deaths from neoplasms, circulatory system and respiratory system causes together. The impacts were stronger in women who died from circulatory system causes, in women with no education and in those aged 75 or older. EEFR interventions had differentiated effects on cold-related mortality in men and women. Differentiated effects were also observed by cause, educational level and age.

  8. Impacts of aerosol direct effects on tropospheric ozone ...

    Science.gov (United States)

    Aerosol direct effects (ADE), i.e., scattering and absorption of incoming solar radiation, reduce radiation reaching the ground and the resultant photolysis attenuation can decrease O3 formation in polluted areas. One the other hand, evidence also suggests that ADE associated cooling suppresses atmospheric ventilation thereby enhancing surface-level O3. Assessment of ADE impacts is thus important for understanding emission reduction strategies that seek co-benefits associated with reductions in both particulate matter and O3 levels. This study quantifies the impacts of ADE on tropospheric ozone by using a two-way online coupled meteorology and atmospheric chemistry model, WRF-CMAQ, instrumented with process analysis methodology. Two manifestations of ADE impacts on O3 including changes in atmospheric dynamics (∆Dynamics) and changes in photolysis rates (∆Photolysis) were assessed separately through multiple scenario simulations for January and July of 2013 over China. Results suggest that ADE reduced surface daily maxima 1h O3 (DM1O3) in China by up to 39 µg m-3 1 through the combination of ∆Dynamics and ∆Photolysis in January, but enhanced surface DM1O3 by up to 4 µg m-3 in July. Increased O3 in July is largely attributed to ∆Dynamics which causes a weaker O3 sink of dry deposition and a stronger O3 source of photochemistry due to the stabilization of atmosphere. Meanwhile, surface OH is also enhanced at noon in July, though its daytime average valu

  9. Emission metrics for quantifying regional climate impacts of aviation

    Directory of Open Access Journals (Sweden)

    M. T. Lund

    2017-07-01

    Full Text Available This study examines the impacts of emissions from aviation in six source regions on global and regional temperatures. We consider the NOx-induced impacts on ozone and methane, aerosols and contrail-cirrus formation and calculate the global and regional emission metrics global warming potential (GWP, global temperature change potential (GTP and absolute regional temperature change potential (ARTP. The GWPs and GTPs vary by a factor of 2–4 between source regions. We find the highest aviation aerosol metric values for South Asian emissions, while contrail-cirrus metrics are higher for Europe and North America, where contrail formation is prevalent, and South America plus Africa, where the optical depth is large once contrails form. The ARTP illustrate important differences in the latitudinal patterns of radiative forcing (RF and temperature response: the temperature response in a given latitude band can be considerably stronger than suggested by the RF in that band, also emphasizing the importance of large-scale circulation impacts. To place our metrics in context, we quantify temperature change in four broad latitude bands following 1 year of emissions from present-day aviation, including CO2. Aviation over North America and Europe causes the largest net warming impact in all latitude bands, reflecting the higher air traffic activity in these regions. Contrail cirrus gives the largest warming contribution in the short term, but remain important at about 15 % of the CO2 impact in several regions even after 100 years. Our results also illustrate both the short- and long-term impacts of CO2: while CO2 becomes dominant on longer timescales, it also gives a notable warming contribution already 20 years after the emission. Our emission metrics can be further used to estimate regional temperature change under alternative aviation emission scenarios. A first evaluation of the ARTP in the context of aviation suggests that further work to account

  10. Emission metrics for quantifying regional climate impacts of aviation

    Science.gov (United States)

    Lund, Marianne T.; Aamaas, Borgar; Berntsen, Terje; Bock, Lisa; Burkhardt, Ulrike; Fuglestvedt, Jan S.; Shine, Keith P.

    2017-07-01

    This study examines the impacts of emissions from aviation in six source regions on global and regional temperatures. We consider the NOx-induced impacts on ozone and methane, aerosols and contrail-cirrus formation and calculate the global and regional emission metrics global warming potential (GWP), global temperature change potential (GTP) and absolute regional temperature change potential (ARTP). The GWPs and GTPs vary by a factor of 2-4 between source regions. We find the highest aviation aerosol metric values for South Asian emissions, while contrail-cirrus metrics are higher for Europe and North America, where contrail formation is prevalent, and South America plus Africa, where the optical depth is large once contrails form. The ARTP illustrate important differences in the latitudinal patterns of radiative forcing (RF) and temperature response: the temperature response in a given latitude band can be considerably stronger than suggested by the RF in that band, also emphasizing the importance of large-scale circulation impacts. To place our metrics in context, we quantify temperature change in four broad latitude bands following 1 year of emissions from present-day aviation, including CO2. Aviation over North America and Europe causes the largest net warming impact in all latitude bands, reflecting the higher air traffic activity in these regions. Contrail cirrus gives the largest warming contribution in the short term, but remain important at about 15 % of the CO2 impact in several regions even after 100 years. Our results also illustrate both the short- and long-term impacts of CO2: while CO2 becomes dominant on longer timescales, it also gives a notable warming contribution already 20 years after the emission. Our emission metrics can be further used to estimate regional temperature change under alternative aviation emission scenarios. A first evaluation of the ARTP in the context of aviation suggests that further work to account for vertical sensitivities

  11. The Canyon Diablo impact event: Projectile motion through the atmosphere

    Science.gov (United States)

    Artemieva, N.; Pierazzo, E.

    2009-03-01

    -forming swarm and land on the plains (tens of km away from the crater) as individual meteorites. Starting from an impactor pre-atmospheric velocity of ~18 km/s, which represents an average value for Earth-crossing asteroids, we find that after disruption, the most probable impact velocity at the Earth’s surface for a tight swarm is around 15 km/s or higher. A highly dispersed swarm would result in a much stronger deceleration of the fragments but would produce a final crater much shallower than observed at Meteor Crater.

  12. Making a global impact.

    Science.gov (United States)

    2015-12-12

    How can vets, individually and collectively, make an impact on the global stage? Addressing this question at the BVA Congress at the London Vet Show, René Carlson, president of the World Veterinary Association, encouraged the profession to play its part locally, nationally and internationally, in tackling current challenges. Kristy Ebanks reports. British Veterinary Association.

  13. impact on embryo quality

    Directory of Open Access Journals (Sweden)

    Marijan Tandara

    2013-05-01

    Conclusions: In men with poorer semen quality, evaluated by standard semen parameters, a higher proportion of sperm with damaged DNA can also be expected. Higher sperm DNA damage, established by Halosperm test, also had an impact on embryo quality in this group of patients.

  14. Ideas. Innovation. Impact.

    International Development Research Centre (IDRC) Digital Library (Canada)

    A BRIEF HISTORY. Ideas. Innovation. Impact. SINCE 1970. 12,828 research activities funded. $2.8 billion in grants provided. 4,217 recipient institutions involved. 4,000+ ... communications linking the people of Mongolia. A smooth transition from apartheid ... and communication technologies for development, to name a few.

  15. CSIR Technology Impact 1990

    CSIR Research Space (South Africa)

    CSIR

    1990-01-01

    Full Text Available Technology impact report, it’s a selection of report on successful co-operation between the CSIR and South African industry in 1989/1990. This publication aims to measure and highlight the success of the CSIR outputs....

  16. Woodworking & housing: impacts & actions

    Science.gov (United States)

    Matt Bumgardner; Urs Buehlmann; Karen. Koenig

    2015-01-01

    The woodworking industry relies heavily on the construction-based markets, particularly those companies involved in cabinetry, furniture, millwork and components. Market conditions, trends and investments all have an impact. It's against this backdrop, that the sixth annual housing market study was conducted in early 2015. A joint effort by Virginia Tech, the U.S...

  17. CSIR Technology Impact 2001

    CSIR Research Space (South Africa)

    CSIR

    2001-01-01

    Full Text Available This issue of Technology Impact offers a brief snapshot of CSIR activities during the year under review (1 March 2000 - 28 February 2001) by highlighting a number of innovative projects and initiatives in these areas. It present a rich canvas...

  18. The impact of ergonomics

    NARCIS (Netherlands)

    Koningsveld, E.A.P.

    2009-01-01

    Ergonomists offer services to organizations. The goal of their work is to provide safety and health at work in combination with a sound human performance. However, the impact of ergonomics efforts is not always as good as ergonomists and human factors specialists want. This chapter aims to support

  19. The impact of emissions

    NARCIS (Netherlands)

    Goetheer, E.L.V.; Trap, H.C.; Gijp, S. van der

    2010-01-01

    The atmospheric concentration of greenhouse gases (GHGs), e.g. CO2 methane, nitrous oxide, and chlorofluorocarbons, has increased gradually in the last century. The intergovernmental Panel on Climate Changes (IPCC) has evaluated the size and impact of this increase. One of the conclusions is that

  20. Bouldery Impact Ejecta

    Science.gov (United States)

    2004-01-01

    29 November 2004 Meteor impact craters are common the surfaces of most solid objects in the Solar System. They are least common on the volcanically-active moon of Jupiter, Io, and on Earth, where volcanism, tectonism, and erosion have all acted to erase the record of impact cratering. On Mars, erosion has also been vigorous enough to destroy craters. In other areas on Mars, craters have been filled and buried within the planet's bedrock. This October 2004 Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a relatively young impact crater on the floor of the outflow channel system of Mangala Valles. The impact ejecta blanket in this case is quite bouldery. Some windblown sediment has partially filled the crater. These features are located near 15.1oS, 149.3oW. The crater is just over 300 meters across, about one third the diameter of the famous Meteor Crater in Arizona. The 300 meter scale bar is about 328 yards long. Sunlight illuminates the scene from the upper left.

  1. Impact of rankings

    NARCIS (Netherlands)

    Westerheijden, Donald F.; van Vught, Franciscus A.; Ziegele, Frank

    2012-01-01

    This chapter discusses the influence league table performance can have on an institution, affecting its student recruitment, its funding and even its leadership. It goes on to discuss the impact on the sector as a whole in encouraging a frantic reputation race and leading institutions to concentrate

  2. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  3. Impacts of Interactive Stratospheric Chemistry on Antarctic and Southern Ocean Climate Change in the Goddard Earth Observing System Version 5 (GEOS-5)

    Science.gov (United States)

    Li, Feng; Vikhliaev, Yury V.; Newman, Paul A.; Pawson, Steven; Perlwitz, Judith; Waugh, Darryn W.; Douglass, Anne R.

    2016-01-01

    Stratospheric ozone depletion plays a major role in driving climate change in the Southern Hemisphere. To date, many climate models prescribe the stratospheric ozone layer's evolution using monthly and zonally averaged ozone fields. However, the prescribed ozone underestimates Antarctic ozone depletion and lacks zonal asymmetries. In this study we investigate the impact of using interactive stratospheric chemistry instead of prescribed ozone on climate change simulations of the Antarctic and Southern Ocean. Two sets of 1960-2010 ensemble transient simulations are conducted with the coupled ocean version of the Goddard Earth Observing System Model, version 5: one with interactive stratospheric chemistry and the other with prescribed ozone derived from the same interactive simulations. The model's climatology is evaluated using observations and reanalysis. Comparison of the 1979-2010 climate trends between these two simulations reveals that interactive chemistry has important effects on climate change not only in the Antarctic stratosphere, troposphere, and surface, but also in the Southern Ocean and Antarctic sea ice. Interactive chemistry causes stronger Antarctic lower stratosphere cooling and circumpolar westerly acceleration during November-December-January. It enhances stratosphere-troposphere coupling and leads to significantly larger tropospheric and surface westerly changes. The significantly stronger surface wind stress trends cause larger increases of the Southern Ocean Meridional Overturning Circulation, leading to year-round stronger ocean warming near the surface and enhanced Antarctic sea ice decrease.

  4. The Winfrith horizontal impact rig

    International Nuclear Information System (INIS)

    Barr, P.

    1985-12-01

    The Horizontal Impact Rig has been designed to allow studies of the impact of radioactive material transport containers and their associated transport vehicles and impact limiters, using large scale models, and to allow physically large missiles to be projected for studying the impact behaviour of metal and concrete structures. It provides an adequately rigid support structure for impact experiments with targets of large dimensions. Details of its design, instrumentation, performance prediction and construction are given. (U.K.)

  5. Impacts into porous asteroids

    Science.gov (United States)

    Housen, Kevin R.; Sweet, William J.; Holsapple, Keith A.

    2018-01-01

    Many small bodies in the solar system have bulk density well below the solid density of the constituent mineral grains in their meteorite counterparts. Those low-density bodies undoubtedly have significant porosity, which is a key factor that affects the formation of impact craters. This paper summarizes the results of lab experiments in which materials with porosity ranging from 43% to 96% were impacted at ∼1800 m/s. The experiments were performed on a geotechnical centrifuge, in order to reproduce the lithostatic overburden stress and ejecta ballistics that occur in large-scale cratering events on asteroids or planetary satellites. Experiments performed at various accelerations, up to 514G, simulate the outcomes of impacts at size scales up to several tens of km in diameter. Our experiments show that an impact into a highly porous cohesionless material generates a large ovoid-shaped cavity, due to crushing by the outgoing shock. The cavity opens up to form a transient crater that grows until the material flow is arrested by gravity. The cavity then collapses to form the final crater. During collapse, finely crushed material that lines the cavity wall is carried down and collected in a localized region below the final crater floor. At large simulated sizes (high accelerations), most of the crater volume is formed by compaction, because growth of the transient crater is quickly arrested. Nearly all ejected material falls back into the crater, leaving the crater without an ejecta blanket. We find that such compaction cratering and suppression of the ejecta blankets occur for large craters on porous bodies when the ratio of the lithostatic stress at one crater depth to the crush strength of the target exceeds ∼0.005. The results are used to identify small solar system bodies on which compaction cratering likely occurs. A model is developed that gives the crater size and ejecta mass that would result for a specified impact into a porous object.

  6. A modified dis-impaction spring for impacted canines

    Directory of Open Access Journals (Sweden)

    Syed Omar Aziz Rizvi

    2015-01-01

    Full Text Available Tooth impaction is the retardation in the eruption pattern of a tooth. One of the most commonly impacted teeth is the maxillary canine. However, impaction of mandibular canines is not as common as maxillary canines. Treatment of such impacted teeth usually involves surgical exposure, followed by bonding of an orthodontic attachment to facilitate extrusive movement of the impacted tooth. However, some side-effects on other teeth can be expected which includes the intrusion and tipping of adjacent teeth. In order to prevent side-effects on the adjacent teeth, we present a modified uprighting spring used to extrude an impacted canine.

  7. Coal transport demand in Western Europe and Japan: Impacts of energy market liberalisation and climate policy

    International Nuclear Information System (INIS)

    Golombek, Rolf; Kittelsen, Sverre A.C.; Maestad, Ottar

    2005-12-01

    Western Europe and Japan are among the main importers of coal. Climate policies following the Kyoto agreement are creating pressure to substitute away from coal and turn to less emission intensive energy sources. At the same time, liberalizations of energy markets in Europe and Japan are likely to cause reduced electricity prices, which will boost the overall demand for electricity. This paper analyses the combined effect of electricity market liberalization and climate policies on the international coal trade. Using the numerical equilibrium model LIBEMOD, we find that while liberalization of electricity markets will imply a large increase in aggregate coal transport demand, the negative impact of climate policies may be even larger, in particular if Russia and Ukraine utilise their market power in the market for emission permits. If this market power is exploited, the total effect of liberalisation and climate policy - when including the impact of general economic growth - is a 20% reduction in aggregate coal transport between 2000 and 2010. Further, impacts differ markedly between Western Europe and Japan. A main difference is that liberalisation has a much more positive - and climate policies have a much stronger negative - impact on steam coal demand in Western Europe than in Japan

  8. Impact Assessment of the Fish for Every Family Project in Occidental Mindoro, Philippines

    Directory of Open Access Journals (Sweden)

    Lei A. Pangilinan

    2017-11-01

    Full Text Available Fish for Every Family Project (FFEFP is one of the initiatives of Plan International that responds to the issue of malnutrition among Filipino children. FFEFP aims to promote and develop backyard tilapia fish farming in Isabela, Mindoro Occidental, Southern Leyte, and Western Samar, Philippines. These are the areas in the country where malnutrition is commonly observed. This study explores the adoption to The Fish for Every Family Project (FFEFP, and assesses its impacts in different levels. This impact assessment of FFEFP was conducted in Occidental Mindoro. The researchers used purposive sampling to touch base directly with a representative sample of the FFEFP beneficiaries in three out of four municipalities in Mindoro Occidental. The data were gathered through focus group discussions with the key officials in the area and some tilapia cage culture technology adopters. Key informant interviews (KIIs of all project stakeholders were also conducted as well. In order to validate the information gathered from the respondents and to see the fish farms used, field visits and ocular inspection were made. The study revealed that the FFEFP has various impacts to the beneficiaries, adopters, and replicators of tilapia. The impacts occurred at three levels: individual, family, and community. It was found out that the project was able to provide self-satisfaction among the beneficiaries and build stronger relationships among the members of the family and of the community.

  9. Aging and effort expenditure: The impact of subjective perceptions of task demands.

    Science.gov (United States)

    Hess, Thomas M; Smith, Brian T; Sharifian, Neika

    2016-11-01

    Engagement in cognitively demanding activities has a positive impact on cognitive health in older adults. Previous work, however, has suggested that the costs associated with engagement increase in later life and influence motivation. We examined how subjective perceptions of these costs varied with age and influenced task engagement. The following questions were of specific interest: (a) Are there age differences in subjective perceptions of cognitive costs? (b) What is the impact of these perceptions on engagement? We tested 39 older (ages 65-84) and 37 younger (20-42) adults on a working memory task. Systolic blood pressure responsivity (SBP-R; reflective of effort) and subjective perceptions of task difficulty were assessed. We found that age was associated with an increase in the perceptions of cognitive costs, and that these subjective perceptions had a stronger impact on older adults' engagement than on that of younger adults. More important, this impact was specific to subjective perceptions of cognitive costs. The results provide further support for the hypothesis that increased costs associated with cognitive engagement influence older adults' willingness to engage cognitive resources, and that these costs in part reflect subjective perceptions that are independent of objective task demands. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  10. Assessment of Genetics Understanding. Under What Conditions Do Situational Features Have an Impact on Measures?

    Science.gov (United States)

    Schmiemann, Philipp; Nehm, Ross H.; Tornabene, Robyn E.

    2017-12-01

    Understanding how situational features of assessment tasks impact reasoning is important for many educational pursuits, notably the selection of curricular examples to illustrate phenomena, the design of formative and summative assessment items, and determination of whether instruction has fostered the development of abstract schemas divorced from particular instances. The goal of our study was to employ an experimental research design to quantify the degree to which situational features impact inferences about participants' understanding of Mendelian genetics. Two participant samples from different educational levels and cultural backgrounds (high school, n = 480; university, n = 444; Germany and USA) were used to test for context effects. A multi-matrix test design was employed, and item packets differing in situational features (e.g., plant, animal, human, fictitious) were randomly distributed to participants in the two samples. Rasch analyses of participant scores from both samples produced good item fit, person reliability, and item reliability and indicated that the university sample displayed stronger performance on the items compared to the high school sample. We found, surprisingly, that in both samples, no significant differences in performance occurred among the animal, plant, and human item contexts, or between the fictitious and "real" item contexts. In the university sample, we were also able to test for differences in performance between genders, among ethnic groups, and by prior biology coursework. None of these factors had a meaningful impact upon performance or context effects. Thus some, but not all, types of genetics problem solving or item formats are impacted by situational features.

  11. Social Impact Assessment in Europe

    DEFF Research Database (Denmark)

    Larsen, Sanne Vammen; Hansen, Anne Merrild; Lyhne, Ivar

    2015-01-01

    Social impact assessment (SIA) is applied worldwide to assess social impacts of plans and projects. In Europe, directives on environmental assessment (EA) require attention to social impacts, however, there is a need to investigate the implementation in practise. To this end, we study three Danish...... cases, which are characterised by debates and conflicts on social issues. Analysis of the EA statements shows inclusion of a broad range of social impacts. However, the EAs do not fully match the concerns of the public, and social impacts are not always analysed in depth, mitigation measures...... are not suggested or are postponed and the geographical distribution of impacts assessed is biased towards including negative local impacts. We discuss the scope and handling of social impacts, and possible implications. Based on this, we conclude with the view that EA might do the job of handling social impacts...

  12. Potential factors impacting season-long expression of Cry1Ac in 13 commercial varieties of Bollgard® cotton

    Directory of Open Access Journals (Sweden)

    John J. Adamczyk, Jr.

    2001-11-01

    Full Text Available Thirteen commercial varieties of transgenic Cry1Ac Bacillus thuringiensis Berliner (Bt cotton were examined across two sites in 2000 for potential factors that impact endotoxin expression. In all cases, two varieties (NuCOTN 33B and DP 458B/RR, Delta and Pineland Co., Scott, MS expressed more Cry1Ac than the other 11 varieties in various plant structures. These two varieties share the same parental background (DP 5415. Furthermore, when the next generation of plants were tested in the greenhouse, the same varietal patterns were exhibited. These data strongly suggest that factors such as parental background had a stronger impact on the expression of Cry1Ac than the environment.

  13. Well-connected leaders: the impact of leaders' social network ties on LMX and members' work attitudes.

    Science.gov (United States)

    Venkataramani, Vijaya; Green, Stephen G; Schleicher, Deidra J

    2010-11-01

    We examined the proposition that leaders' social network ties in the larger organization influence the quality of their leader-member exchange (LMX) with their employees, which, in turn, impacts these employees' job satisfaction and turnover intentions. Using multilevel, multisource data from a field study of 184 bank employees nested within 42 branch managers, we found that leaders who had higher quality relationships with their bosses and who were more central in their peer networks were perceived by their subordinates as having greater status in the organization and, therefore, were able to form higher quality relationships with them. Further, the effects of the leaders' perceived status on LMX were stronger when subordinates were less central in their own peer network. Finally, LMX mediated the impact of leaders' perceived status in the organization on subordinates' job satisfaction and turnover intentions. Implications for theory and practice are discussed. (c) 2010 APA, all rights reserved.

  14. Self-regulation and selective exposure: the impact of depleted self-regulation resources on confirmatory information processing.

    Science.gov (United States)

    Fischer, Peter; Greitemeyer, Tobias; Frey, Dieter

    2008-03-01

    In the present research, the authors investigated the impact of self-regulation resources on confirmatory information processing, that is, the tendency of individuals to systematically prefer standpoint-consistent information to standpoint-inconsistent information in information evaluation and search. In 4 studies with political and economic decision-making scenarios, it was consistently found that individuals with depleted self-regulation resources exhibited a stronger tendency for confirmatory information processing than did individuals with nondepleted self-regulation resources. Alternative explanations based on processes of ego threat, cognitive load, and mood were ruled out. Mediational analyses suggested that individuals with depleted self-regulation resources experienced increased levels of commitment to their own standpoint, which resulted in increased confirmatory information processing. In sum, the impact of ego depletion on confirmatory information search seems to be more motivational than cognitive in nature.

  15. Unlimited access to health care - impact of psychosomatic co-morbidity on utilisation in German general practices

    Science.gov (United States)

    2011-01-01

    Background The effect of psychosomatic co-morbidity on resource use for systems with unlimited access remains unclear. The aim of this study was to evaluate the impact on practice visits, referrals and periods of disability in German general practices and to identify predictors of health care utilisation. Methods Cross sectional observational study in 13 practices in Upper Bavaria. Patients were included consecutively and filled in the Patients Health Questionnaire (PHQ). Numbers of practice visits, referrals and periods of disability within the last twelve months and permanent mental and somatic diagnoses were extracted manually by review of the computerised charts. Physicians in Germany are obliged to document repetitive reasons of encounter as permanent diagnoses in terms of ICD-10-codes. These ICD-10-codes are used for legitimisation of reimbursement in German general practices. Results 1005 patients were included (58.6% female). On average, patients had 15.3 (sd 16.3) practice contacts, 3.8 (sd 4.2) referrals and 7.5 (sd 23.1) days of disability per year. The mean number of coded permanent diagnoses was 0.4 (sd 0.7) for mental and 4.0 (sd 4.0) for somatic diagnoses. Patients with mental diagnoses scored higher in depression, anxiety, panic and somatoform disorder scales of PHQ. Frequent practice visits were associated stronger with coded permanent mental diagnoses (OR 20.0; 95%CI 7.5-53.9) than with coded permanent somatic diagnoses (OR 14.4; 95%CI 5.9-35.4). Frequent referrals were associated stronger with somatic diagnoses (OR 4.9; 95%CI 2.0-11.9) than with mental diagnoses (OR 3.6; 95%CI 1.4-9.8). Periods of disability were predicted by mental diagnoses (OR 5.0; 95%CI 1.6-15.8) but not by somatic diagnoses (OR 2.5; 95%CI 0.7-8.1). Conclusions Psychosomatic co-morbidity has a stronger impact on health care utilisation in German general practices with respect to practice visits and periods of disability whereas somatic disorders play a stronger role for

  16. Impact of the cell division cycle on gene circuits

    Science.gov (United States)

    Bierbaum, Veronika; Klumpp, Stefan

    2015-12-01

    In growing cells, protein synthesis and cell growth are typically not synchronous, and, thus, protein concentrations vary over the cell division cycle. We have developed a theoretical description of genetic regulatory systems in bacteria that explicitly considers the cell division cycle to investigate its impact on gene expression. We calculate the cell-to-cell variations arising from cells being at different stages in the division cycle for unregulated genes and for basic regulatory mechanisms. These variations contribute to the extrinsic noise observed in single-cell experiments, and are most significant for proteins with short lifetimes. Negative autoregulation buffers against variation of protein concentration over the division cycle, but the effect is found to be relatively weak. Stronger buffering is achieved by an increased protein lifetime. Positive autoregulation can strongly amplify such variation if the parameters are set to values that lead to resonance-like behaviour. For cooperative positive autoregulation, the concentration variation over the division cycle diminishes the parameter region of bistability and modulates the switching times between the two stable states. The same effects are seen for a two-gene mutual-repression toggle switch. By contrast, an oscillatory circuit, the repressilator, is only weakly affected by the division cycle.

  17. On impact fusion

    International Nuclear Information System (INIS)

    Winterberg, F.

    1997-01-01

    Impact fusion is a promising, but much less developed road towards inertial confinement fusion. It offers an excellent solution to the so-called stand-off problem for thermonuclear microexplosions but is confronted with the challenge to accelerate macroscopic particles to the needed high velocities of 10 2 -10 3 km/s. To reach these velocities, two ways have been studied in the past. The electric acceleration of a beam of microparticles, with the particles as small as large clusters, and the magnetic acceleration of gram-size ferromagnetic or superconducting projectiles. For the generation of an intense burst of soft X-rays used for the indirect drive, impact fusion may offer new promising possibilities

  18. Perceived Impacts of Sport

    Directory of Open Access Journals (Sweden)

    IOANNIS DOUVIS

    2008-01-01

    Full Text Available It was the purpose of this preliminary project to measure how individuals perceive the impacts of sport in such areas as the economy, the environment, culture, community image and the quality of life, among other areas. The instrument was initially field tested in 1999 with a sample of 702 residents in the North eastern part of the United States. Their views suggest that they perceive sports to make a generally positive contribution to their communities and the local region. Some negative impacts were also identified, mostly of an environmental nature. However, the findings suggest that sports for the most part are perceived to play a major role in the lives of people and contribute in significant ways to the economy, and community pride.

  19. Reducing Impacts of Forestry

    DEFF Research Database (Denmark)

    Weidema, Bo Pedersen

    2013-01-01

    New definitions are provided of intensive and extensive forestry in version 3 of the ecoinvent database. These definitions are based on explicit and easily measured indicators for the most important aspects of forestry management for biodiversity. Unfortunately, many certified forestry products...... come from what would be classified as intensive forestry in the ecoinvent classification. The real challenge is to develop forest management systems that have a neutral or positive biodiversity impact relative to that of plantation forestry. Such truly extensive, biodiversity-managed forestry is very...... challenging and not very common today. Ample options exist for increasing yields in intensive and plantation forests, which can be recommended as having lower biodiversity impact than similar products from other management systems, certified or not....

  20. Cross-impact method

    Directory of Open Access Journals (Sweden)

    Suzić Nenad

    2014-01-01

    Full Text Available The paper displays the application of the Cross-Impact method in pedagogy, namely a methodological approach which crosses variables in a novel, but statistically justified manner. The method is an innovation in pedagogy as well as in research methodology of social and psychological phenomena. Specifically, events and processes are crossed, that is, experts' predictions of about future interaction of events and processes. Therefore, this methodology is futuristic; it concerns predicting future, which is of key importance for pedagogic objectives. The paper presents two instances of the cross-impact approach: the longer, displayed in fourteen steps, and the shorter, in four steps. They are both accompanied with mathematic and statistical formulae allowing for quantification, that is, a numerical expression of the probability of a certain event happening in the future. The advantage of this approach is that it facilitates planning in education which so far has been solely based on lay estimates and assumptions.

  1. Pipe whip and impact

    International Nuclear Information System (INIS)

    Attwood, G.J.

    1987-01-01

    Over the past few years changes in economic and safety considerations in nuclear power plants have resulted in a need to examine the problem of pipe whip in greater detail. Consequently, experimental programmes were set up in France, North America and Britain. Results from these tests combined with analytical work indicate that pipe whip followed by impact with surrounding pipework and structures may not be as serious as had been believed. Impact loads have been found to be much less (at least five times) than those predicted to the appropriate design regulations. Hence, the use of pipe whip restraints may have been overconservative. The use of fewer, better designed restraints, would result in greater accessibility of pipework, a reduced need for inspection of restraints, and a considerable financial saving. (author)

  2. Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.; Hauschild, Michael Zwicky; Boulay, Anne-Marie

    2017-01-01

    by LCA software, but the underlying principles, models and factors should still be well understood by practitioners to ensure the insight that is needed for a qualified interpretation of the results. This chapter teaches the fundamentals of LCIA and opens the black box of LCIA with its characterisation...... models and factors to inform the reader about: (1) the main purpose and characteristics of LCIA, (2) the mandatory and optional steps of LCIA according to the ISO standard, and (3) the science and methods underlying the assessment for each environmental impact category . For each impact category......, the reader is taken through (a) the underlying environmental problem, (b) the underlying environmental mechanism and its fundamental modelling principles, (c) the main anthropogenic sources causing the problem and (d) the main methods available in LCIA. An annex to this book offers a comprehensive...

  3. Ankyloglossia its impact breastfeeding.

    Science.gov (United States)

    Henry, Lydia; Hayman, Rebecca

    2014-01-01

    This article contrasts two very different experiences of one mother breastfeeding her two sons to demonstrate the potential impact of ankyloglossia on breastfeeding. When too restrictive, ankyloglossia, also known as tongue-tie, can cause the newborn to ineffectively suckle at the breast. Breastfeeding difficulties can occur, such as long feedings or damaged nipples. When nurses, lactation consultants and other providers recognize this situation, they can refer women for further care and treatment, which can ultimately lead to breastfeeding success. © 2014 AWHONN.

  4. Impacts of Artificial Intelligence

    OpenAIRE

    Trappl, R.

    1986-01-01

    This book, which is intended to serve as the first stage in an iterative process of detecting, predicting, and assessing the impacts of Artificial Intelligence opens with a short "one-hour course" in AI, which is intended to provide a nontechnical informative introduction to the material which follows. Next comes an overview chapter which is based on an extensive literature search, the position papers, and discussions. The next section of the book contains position papers whose richness...

  5. Impact craters on Titan

    Science.gov (United States)

    Wood, Charles A.; Lorenz, Ralph; Kirk, Randy; Lopes, Rosaly; Mitchell, Karl; Stofan, Ellen; ,

    2010-01-01

    Five certain impact craters and 44 additional nearly certain and probable ones have been identified on the 22% of Titan's surface imaged by Cassini's high-resolution radar through December 2007. The certain craters have morphologies similar to impact craters on rocky planets, as well as two with radar bright, jagged rims. The less certain craters often appear to be eroded versions of the certain ones. Titan's craters are modified by a variety of processes including fluvial erosion, mass wasting, burial by dunes and submergence in seas, but there is no compelling evidence of isostatic adjustments as on other icy moons, nor draping by thick atmospheric deposits. The paucity of craters implies that Titan's surface is quite young, but the modeled age depends on which published crater production rate is assumed. Using the model of Artemieva and Lunine (2005) suggests that craters with diameters smaller than about 35 km are younger than 200 million years old, and larger craters are older. Craters are not distributed uniformly; Xanadu has a crater density 2-9 times greater than the rest of Titan, and the density on equatorial dune areas is much lower than average. There is a small excess of craters on the leading hemisphere, and craters are deficient in the north polar region compared to the rest of the world. The youthful age of Titan overall, and the various erosional states of its likely impact craters, demonstrate that dynamic processes have destroyed most of the early history of the moon, and that multiple processes continue to strongly modify its surface. The existence of 24 possible impact craters with diameters less than 20 km appears consistent with the Ivanov, Basilevsky and Neukum (1997) model of the effectiveness of Titan's atmosphere in destroying most but not all small projectiles.

  6. Second-impact syndrome.

    Science.gov (United States)

    Cantu, R C

    1998-01-01

    Second impact syndrome (SIS) occurs when an athlete who has sustained an initial head injury, most often a concussion, sustains a second head injury before symptoms associated with the first have fully cleared. While most commonly reported in football, the SIS can occur during any sport that can produce head blows. Any athlete still complaining of post-concussion symptoms after a head injury must not be allowed to return to play.

  7. Hypervelocity impact of concrete

    International Nuclear Information System (INIS)

    Watson, A.J.; Anderson, W.F.; Archer, B.

    1982-01-01

    Blocks of concrete and various other materials were impacted by high speed copper jets at the centre of one face, the resulting transient phenomena were measured using ultra high speed photography and various electrical signal transducers. Measurements were made of the jet velocity, penetration rate, crack velocity and initiation time, and strain pulse propagation. Post test measurements were made using electron microscopy, ultra sonics and stereoscopic photography. (orig.) [de

  8. Novel Research Impact Indicators

    Directory of Open Access Journals (Sweden)

    Martin Fenner

    2014-04-01

    Full Text Available Citation counts and more recently usage statistics provide valuable information about the attention and research impact associated with scholarly publications. The open access publisher Public Library of Science (PLOS has pioneered the concept of article-level metrics, where these metrics are collected on a per article and not a per journal basis and are complemented by real-time data from the social web or altmetrics: blog posts, social bookmarks, social media and other.

  9. Towards enhanced CSR impact?

    International Nuclear Information System (INIS)

    Lunde, Leiv; Swanson, Phil

    2004-01-01

    This paper was produced by ECON Analysis in conjunction with the Fridtjof Nansen Institute (FNI) for the Norwegian Research Council's 'Petropol' programme. It is part of a joint project entitled, 'Oil companies and the new petroleum provinces: ethics, business and politics'. This paper examines the possibilities for partnerships between oil companies and multilateral government institutions to address the negative impacts of oil projects that often prevent the resulting revenues leading to social and economic benefits for the host country (author) (ml)

  10. Geothermal environmental impact

    International Nuclear Information System (INIS)

    Armannsson, H.; Kristmannsdottir, H.

    1992-01-01

    Geothermal utilization can cause surface disturbances, physical effects due to fluid withdrawal noise, thermal effects and emission of chemicals as well as affect the communities concerned socially and economically. The environmental impact can be minimized by multiple use of the energy source and the reinjection of spent fluids. The emission of greenhouse gases to the atmosphere can be substantially reduced by substituting geothermal energy for fossil fuels as an industrial energy source wherever possible

  11. Knowledge dissemination: Determining impact

    CSIR Research Space (South Africa)

    Molapo, D

    2007-07-17

    Full Text Available Impact A Paper Presented at IFLA Durban 2007 Knowledge Management (KM) Best Practices/Lessons Learned 1 Day Workshop 17 August, 2007 Howard College Campus of the University of Kwazulu Natal Presented... cannot be assessed without information about the (extent) number of users and the degree (intensity) of adoption of improved techniques, and the incremental effects of these techniques on the production costs and output. The adoption of any technology...

  12. Milestones and Impact Factors

    Directory of Open Access Journals (Sweden)

    Grandjean Philippe

    2010-07-01

    Full Text Available Abstract Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact.

  13. Fragment Impact Toolkit (FIT)

    Energy Technology Data Exchange (ETDEWEB)

    Shevitz, Daniel Wolf [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Key, Brian P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Garcia, Daniel B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-05

    The Fragment Impact Toolkit (FIT) is a software package used for probabilistic consequence evaluation of fragmenting sources. The typical use case for FIT is to simulate an exploding shell and evaluate the consequence on nearby objects. FIT is written in the programming language Python and is designed as a collection of interacting software modules. Each module has a function that interacts with the other modules to produce desired results.

  14. Impact test of components

    International Nuclear Information System (INIS)

    Borsoi, L.; Buland, P.; Labbe, P.

    1987-01-01

    Stops with gaps are currently used to support components and piping: it is simple, low cost, efficient and permits free thermal expansion. In order to keep the nonlinear nature of stops, such design is often modeled by beam elements (for the component) and nonlinear springs (for the stops). This paper deals with the validity and the limits of these models through the comparison of computational and experimental results. The experimental results come from impact laboratory tests on a simplified mockup. (orig.)

  15. The impact of servant leadership dimensions on leader–member exchange among health care professionals

    DEFF Research Database (Denmark)

    Johansson Hanse, Jan; Harlin, Ulrika; Jarebrant, Caroline

    2016-01-01

    Aim The aim of the current study was to investigate the impact of servant leadership dimensions on leader–member exchange (LMX) among health-care professionals. Background Leadership support and the quality of the dyadic relationship between the leader and the employee are essential regarding...... the work environment and turnover intentions in health care. Method A questionnaire-based cross-sectional study was undertaken at four hospital units in Sweden. The study sample included 240 employees. Results Significant bivariate correlations were found between all servant leadership dimensions and LMX...... leadership dimensions were strongly related to LMX. Implications for nursing management The results identify specific servant leadership dimensions that are likely to be useful for developing a stronger exchange relationship between the leader (e.g. nursing manager) and individual subordinates in health care....

  16. The impact of servant leadership dimensions on leader-member exchange among health care professionals.

    Science.gov (United States)

    Hanse, Jan Johansson; Harlin, Ulrika; Jarebrant, Caroline; Ulin, Kerstin; Winkel, Jörgen

    2016-03-01

    The aim of the current study was to investigate the impact of servant leadership dimensions on leader-member exchange (LMX) among health-care professionals. Leadership support and the quality of the dyadic relationship between the leader and the employee are essential regarding the work environment and turnover intentions in health care. A questionnaire-based cross-sectional study was undertaken at four hospital units in Sweden. The study sample included 240 employees. Significant bivariate correlations were found between all servant leadership dimensions and LMX. The strongest correlations were found between 'humility' and LMX (r = 0.69, P leadership dimensions were strongly related to LMX. The results identify specific servant leadership dimensions that are likely to be useful for developing a stronger exchange relationship between the leader (e.g. nursing manager) and individual subordinates in health care. © 2015 John Wiley & Sons Ltd.

  17. Culture, gender, and the self: variations and impact of social comparison processes.

    Science.gov (United States)

    Guimond, Serge; Branscombe, Nyla R; Brunot, Sophie; Buunk, Abraham P; Chatard, Armand; Désert, Michel; Garcia, Donna M; Haque, Shamsul; Martinot, Delphine; Yzerbyt, Vincent

    2007-06-01

    Psychological differences between women and men, far from being invariant as a biological explanation would suggest, fluctuate in magnitude across cultures. Moreover, contrary to the implications of some theoretical perspectives, gender differences in personality, values, and emotions are not smaller, but larger, in American and European cultures, in which greater progress has been made toward gender equality. This research on gender differences in self-construals involving 950 participants from 5 nations/cultures (France, Belgium, the Netherlands, the United States, and Malaysia) illustrates how variations in social comparison processes across cultures can explain why gender differences are stronger in Western cultures. Gender differences in the self are a product of self-stereotyping, which occurs when between-gender social comparisons are made. These social comparisons are more likely, and exert a greater impact, in Western nations. Both correlational and experimental evidence supports this explanation. (c) 2007 APA, all rights reserved.

  18. The Impact of Pet Loss on the Perceived Social Support and Psychological Distress of Hurricane Survivors

    Science.gov (United States)

    Lowe, Sarah R.; Rhodes, Jean E.; Zwiebach, Liza; Chan, Christian S.

    2013-01-01

    Associations between pet loss and posthurricane perceived social support and psychological distress were explored. Participants (N = 365) were primarily low-income African American single mothers who were initially part of an educational intervention study. All participants were exposed to Hurricane Katrina, and 47% experienced Hurricane Rita. Three waves of survey data, two from before the hurricanes, were included. Sixty-three participants (17.3%) reported losing a pet due to the hurricanes and their aftermath. Pet loss significantly predicted postdisaster distress, above and beyond demographic variables, pre- and postdisaster perceived social support, predisaster distress, hurricane-related stressors, and human bereavement, an association that was stronger for younger participants. Pet loss was not a significant predictor of postdisaster perceived social support, but the impact of pet loss on perceived social support was significantly greater for participants with low levels of predisaster support. PMID:19462438

  19. Drought evolution: greater and faster impacts on blue water than on green water

    Science.gov (United States)

    Destouni, G.; Orth, R.

    2017-12-01

    Drought propagates through the terrestrial water cycle, affecting different interlinked geospheres which have so far been mostly investigated separately and without direct comparison. By use of comprehensive multi-decadal data from >400 near-natural catchments along a steep climate gradient across Europe we here analyze drought propagation from precipitation (deficits) through soil moisture to runoff (blue water) and evapotranspiration (green water). We show that soil-moisture droughts reduce runoff stronger and faster than evapotranspiration. While runoff responds within weeks, evapotranspiration can be unaffected for months, or even entirely as in central and northern Europe. Understanding these different drought pathways towards blue and green water resources contributes to improve food and water security and offers early warning potential to mitigate (future) drought impacts on society and ecosystems.

  20. The impact of developmental dyslexia and dysgraphia on movement production during word writing.

    Science.gov (United States)

    Kandel, Sonia; Lassus-Sangosse, Delphine; Grosjacques, Géraldine; Perret, Cyril

    This study investigated how deficits in orthographic processing affect movement production during word writing. Children with dyslexia and dysgraphia wrote words and pseudo-words on a digitizer. The words were orthographically regular and irregular of varying frequency. The group analysis revealed that writing irregular words and pseudo-words increased movement duration and dysfluency. This indicates that the spelling processes were active while the children were writing the words. The impact of these spelling processes was stronger for the children with dyslexia and dysgraphia. The analysis of individual performance revealed that most dyslexic/dysgraphic children presented similar writing patterns. However, selective lexical processing deficits affected irregular word writing but not pseudo-word writing. Selective poor sublexical processing affected pseudo-word writing more than irregular word writing. This study suggests that the interaction between orthographic and motor processing constitutes an important cognitive load that may disrupt the graphic outcome of the children with dyslexia/dysgraphia.

  1. Interactivity mitigates the impact of working memory depletion on mental arithmetic performance.

    Science.gov (United States)

    Vallée-Tourangeau, Frédéric; Sirota, Miroslav; Vallée-Tourangeau, Gaëlle

    2016-01-01

    Doing long sums in the absence of complementary actions or artefacts is a multistep procedure that quickly taxes working memory; congesting the phonological loop further handicaps performance. In the experiment reported here, participants completed long sums either with hands down - the low interactivity condition - or by moving numbered tokens - the high interactivity condition - while they repeated "the" continuously, loading the phonological loop, or not. As expected, interactivity and articulatory suppression substantially affected performance; critically, the effect of articulatory suppression was stronger in the low than in the high interactivity condition. In addition, an independent measure of mathematics anxiety predicted the impact of articulatory suppression on performance only in the low (not high) interactivity condition. These findings suggest that interactivity augmented overall or systemic working memory resources and diminished the effect of mathematics anxiety, underscoring the importance of characterizing the properties of the system as it is configured by the dynamic agent-environment coupling.

  2. Impact of deployment on military families with young children: A systematic review.

    Science.gov (United States)

    Trautmann, Jennifer; Alhusen, Jeanne; Gross, Deborah

    2015-01-01

    More than 40% of children in military families are review describes the impact of deployment since 9/11 on the mental health of military families with young children, evaluates evidence-based interventions for military parents with young children, and identifies gaps in the science limiting our ability to support the needs of these families. Databases were reviewed from 2001 to 2014 using preferred reporting items for systematic reviews and meta-analyses approach; 26 studies met review criteria. Deployment was associated with increased parent stress, child behavior problems, health care utilization, and child maltreatment. Few studies tested interventions or focused on racial/ethnic minority or veteran families. A number of methodological limitations are noted. More research using multiple methods, stronger designs, and more diverse samples is needed to understand and address the needs of military families with young children. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Impact of global changes and biotic interactions on food webs in lakes

    DEFF Research Database (Denmark)

    Vidal, Nicolas

    ). This impact seemed to be less drastic in clear water lakes, but the direct effect of exotic fishes predation (consumption) on native fishes was, contrary to our expectations, stronger in the turbid lakes. However, only weak cascading effects of predator introduction were detected; the size of calanoid......The last decades have witnessed unprecedented changes at a global scale including, among others, an increasing human population and goods consumption rates, climate change (warming, changes in precipitation regime), species invasions and globalisation of trade, among others. Aquatic systems...... are exposed to several of these stressors, shallow lakes being particularly vulnerable. Shallow lakes are the most abundant lake type on Earth, hold great biodiversity and act as very important sources of ecosystem services by providing, among other things, drinking water and food. Eutrophication is one...

  4. Environmental Impact Section

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The Section is concerned with preparation of environmental statements and assessments and development of assessment methodologies for energy technologies. During 1976, activities involved nuclear, fossil, and geothermal energy; this work was supported by the U.S.Army, HUD, US ERDA, and US NRC. Two special studies--one on the effects of power plant intake structures on fish impingement and another on multiple uses of cooling lakes--were completed and should serve as references for future analyses. Two research projects sponsored by NRC--the Unified Transport Approach (UTA) to Power Plant Assessment and the Environmental Monitoring Data Evaluation Study--were continued. The purpose of the UA program is to develop fast-transient, one- and two-dimensional transport models for estimating thermal, radiological, chemical, and biological impacts in complicated water bodies. The impact of public use of various products that contain radioactive isotope is being evaluated. The Environmental Impact Sections assistance to NRC expanded to include assessments of fuel-fabrication facilities being considered for relicensing and two uranium in-situ solution mining facility proposals. The work for HUD comprises an assessment of the first application of MIUS in a new town development. A generic environmental statement was prepared and an environmental monitoring program for the facility was designed

  5. Climate impacts on agribusiness

    International Nuclear Information System (INIS)

    Arthur, L.; Kooten, G.C. Van

    1991-01-01

    Predicted effect of climatic change on primary agriculture are combined with knowledge of linkages of agribusiness to primary agriculture to predict the vulnerability of agribusiness to climate change. Prairie economies are extremely dependent on agricultural incomes and activities. Primary agriculture accounts for 17% of Manitoba's value added for goods producing sectors, 40% for Saskatchewan, and 10-15% for Alberta. Additional economic activity is related to providing inputs to agriculture and transporting, marketing or processing agricultural products, and is referred to as agribusiness. Input/output models have been used to relate agribusiness and agriculture impacts, and predict effects ranging from a $1.3 million gain to a $21 million loss. Many climate change scenarios enhance agricultural productivity relative to baseline conditions. Economic impacts will likely be as important due to effects of climate change on world markets and competition as from direct impacts on yields, however studies have shown both increases and decreases in yields from these areas under climate change. 6 refs

  6. Tornado missile impact study

    International Nuclear Information System (INIS)

    McDonald, J.R.

    1991-01-01

    UCRL-15910 specifies wind and tornado missiles for moderate- and high-hazard DOE facilities. Wall-barrier specimens have been tested at the Tornado Missile Impact Facility at Texas Tech University. The facility has an air-activated tornado missile cannon capable of firing 2x4 timber planks weighing 12 lb at speeds up to 150 mph and 3-in-diameter steel pipes weighing 75 lb at speeds to 7 5 mph. Wall barriers tested to date include reinforced concrete walls from 4-in. to 10-in. thick; 8-in. and 12-in. walls of reinforced concrete masonry units (CMU); two other masonry wall configurations consisting of an 8-in. CMU with a 4-in. clay-brick veneer and a 10-in. composite wall with two wythes of 4-in. clay brick. The impact test series is designed to determine the impact speed that will produce backface spall of each wall barrier. A set of 15 wall sections has been constructed and tested at this time. Preliminary finding suggest that all cells of CMU walls must be grouted to prevent missile penetration. Walls recommended in the workshop on UCRL-15910 provide acceptable protection if cracking can be accepted

  7. Aluminum alloy impact sparkling

    Directory of Open Access Journals (Sweden)

    M. Dudyk

    2008-08-01

    Full Text Available The cast machine parts are widely used in many branches of industry. A very important issue is gaining the appropriate knowledge relating to the application of castings in places of explosion risks including but not limited to mining, chemical industry and rescue works. A possibility of explosion risks occurrence following the impact sparkling of the cast metal parts is still not solved problem in scientific research. In relation to this issue, in this article, the results of the study are presented, and relating to the tendency to impact sparkling of the aluminium alloys used in machine building. On the grounds of the results obtained, it was demonstrated that the registered impact sparkles bunches of feathers from the analyzed alloys: AlSi7Mg, (AK7; AlSi9Mg, (AK9; AlSi6Cu4, (AK64 and AlSi11, (AK11 show significant differences between each other. The quantitative analysis of the temperature distribution and nuclei surface area performed on the example of the alloy AK9 (subjected to defined period of corrosion allows for the statement that they are dangerous in conditions of explosion risk. Following this fact, designers and users of machine parts made from these materials should not use them in conditions where the explosive mixtures occur.

  8. Remarks on impact shearing

    Science.gov (United States)

    Klepaczko, J. R.

    1998-10-01

    A review is presented on recent progress in shear testing of materials at high and very high strain rates. Some experimental techniques are discussed which allow for materials testing in shear up to 10 6 ls. More detailed informations are provided on experimental techniques based on the Modified Double Shear specimen loaded by direct impact. This technique has been applied so far to test a variety of materials, including construction, armor and inoxidable steels, and also aluminum alloys. The double shear configuration has also been applied to test sheet metals, mostly used in the automotive industry, in a wide range of strain rates. Details of both techniques, including measuring systems and elastic wave propagation in tubes, are discussed. In addition, a new experimental configuration which can be applied for experimental studies of adiabatic shear propagation and high speed machining is discussed. The role of adiabatic heating at different rates of shearing is also discussed, including transition from pure isothermal to pure adiabatic deformation. It appears that the initial impact velocity is an important parameter in development of plastic localization. Finally, a new development is discussed in determination of the Critical Impact Velocity in shear. A comparison is shown between recent experimental findings and a simple analytic estimation. The CIV in shear is a certain mode of adiabatic failure which occurs at relatively high shear velocities of adjacent material layers. Numerical simulations support the existence of the CIV in shear which can be recognized to some extent as a material constant.

  9. Reactions to perceived fairness : the impact

    NARCIS (Netherlands)

    Bos, K. van den

    2001-01-01

    In correspondence with terror management theory, the findings of two experiments show that reminders of death lead to stronger effects of perceived fairness on ratings of negative affect. Furthermore, in line with the theory’s self-esteem mechanism, results of Experiment 1 suggest that state

  10. Climate Change Impact on ENSO and its Teleconnections with South America

    Science.gov (United States)

    Natori, A. A.; Grimm, A. M.

    2006-12-01

    We analyze the interannual variability of the summer monsoon rainy season in South America and its relationship with SST as simulated by the ocean-atmosphere coupled model ECHAM5-OM for present-day conditions (1961-1990) and future A2 emission scenario (2071-2100). The first mode of model precipitation variability, both in spring and summer, is associated with El Niño- Southern Oscillation (ENSO). In both seasons it features a dipole of anomalies between northern and southeastern South America. These modes correspond, with some differences, to the first variability mode of observed spring precipitation, and to the third variability mode of observed summer precipitation, which are also associated with ENSO. While the relationship between ENSO events and precipitation variability in northern South America strengthens for the A2 scenario, it weakens in southeastern South America, especially in spring, which is presently the season with strongest ENSO-related impact. The ENSO related SST anomalies in the equatorial central-eastern Pacific are stronger in the enhanced emission scenario, which probably explains the stronger connection with northern Brazil via anomalous Walker circulation. However, the ENSO-related latitudinal tropical-subtropical SST gradient in eastern South Pacific is weaker in the projected climate, which reduces the Rossby-wave propagation to southeastern South America, thus weakening the ENSO impact on the circulation and precipitation in this region. Acknowledgments. This study was supported by MMA-Brazil/PROBIO (GEF and BIRD), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq Brazil), and Inter-American Institute for Global Change Research (CRN055).

  11. Understanding Traditional Research Impact Metrics.

    Science.gov (United States)

    Butler, Joseph S; Sebastian, Arjun S; Kaye, I David; Wagner, Scott C; Morrissey, Patrick B; Schroeder, Gregory D; Kepler, Christopher K; Vaccaro, Alexander R

    2017-05-01

    Traditionally, the success of a researcher has been judged by the number of publications he or she has published in peer-review, indexed, high impact journals. However, to quantify the impact of research in the wider scientific community, a number of traditional metrics have been used, including Impact Factor, SCImago Journal Rank, Eigenfactor Score, and Article Influence Score. This article attempts to provide a broad overview of the main traditional impact metrics that have been used to assess scholarly output and research impact. We determine that there is no perfect all-encompassing metric to measure research impact, and, in the modern era, no single traditional metric is capable of accommodating all facets of research impact. Academics and researchers should be aware of the advantages and limitations of traditional metrics and should be judicious when selecting any metrics for an objective assessment of scholarly output and research impact.

  12. Social Impact Assessment for Wetlands

    NARCIS (Netherlands)

    Vanclay, Francis

    2016-01-01

    Social Impact Assessment (SIA) comprises the processes of analyzing, monitoring, and managing the social consequences of planned interventions (Vanclay 2003; Esteves et al. 2012). Planned interventions can be projects, plans, programs, or policies. SIA arose alongside Environmental Impact Assessment

  13. Impact of ethical climate on moral distress revisited: multidimensional view.

    Science.gov (United States)

    Atabay, Gülem; Çangarli, Burcu Güneri; Penbek, Şebnem

    2015-02-01

    Moral distress is a major problem in nursing profession. Researchers identified that the stronger the ethical basis of the organization, the less moral distress is reported. However, different ethical climates may have different impacts on moral distress. Moreover, conceptualization of moral distress and ethical climate as well as their relationship may change according to the cultural context. The main aim of the study is to investigate the relationship between different types of ethical climate as described in Victor and Cullen's framework, and moral distress intensity among nurses in Turkish healthcare settings. An online survey was administrated to collect data. Questionnaires included moral distress and ethical climate scales in addition to demographic questions. Data were collected from registered nurses in Turkey. In all, 201 of 279 nurses completed questionnaires, resulting in a response rate of 72%. Ethical approval was obtained from the university to which the authors were affiliated, after a detailed investigation of the content and data collection method. Factor analyses showed that moral distress had three dimensions, namely, organizational constraints, misinformed and over-treated patients, and lack of time and resources, while ethical climate had four types, namely, rules, well-being of stakeholders, individualism, and organizational interests. Positive correlations were identified between certain types of ethical climate (rules, individualism, or organizational interests) and moral distress intensity. Factor distribution of the scales shows some commonalities with the findings of previous research. However, context-specific dimensions and types were also detected. No particular ethical climate type was found to have a negative correlation with moral distress. Recommendations were made for reducing the negative impact of ethical climate on moral distress. These include solving the nursing-shortage problem, increasing autonomy, and improving physical

  14. Impact of internal variability on projections of Sahel precipitation change

    Science.gov (United States)

    Monerie, Paul-Arthur; Sanchez-Gomez, Emilia; Pohl, Benjamin; Robson, Jon; Dong, Buwen

    2017-11-01

    The impact of the increase of greenhouse gases on Sahelian precipitation is very uncertain in both its spatial pattern and magnitude. In particular, the relative importance of internal variability versus external forcings depends on the time horizon considered in the climate projection. In this study we address the respective roles of the internal climate variability versus external forcings on Sahelian precipitation by using the data from the CESM Large Ensemble Project, which consists of a 40 member ensemble performed with the CESM1-CAM5 coupled model for the period 1920-2100. We show that CESM1-CAM5 is able to simulate the mean and interannual variability of Sahel precipitation, and is representative of a CMIP5 ensemble of simulations (i.e. it simulates the same pattern of precipitation change along with equivalent magnitude and seasonal cycle changes as the CMIP5 ensemble mean). However, CESM1-CAM5 underestimates the long-term decadal variability in Sahel precipitation. For short-term (2010-2049) and mid-term (2030-2069) projections the simulated internal variability component is able to obscure the projected impact of the external forcing. For long-term (2060-2099) projections external forcing induced change becomes stronger than simulated internal variability. Precipitation changes are found to be more robust over the central Sahel than over the western Sahel, where climate change effects struggle to emerge. Ten (thirty) members are needed to separate the 10 year averaged forced response from climate internal variability response in the western Sahel for a long-term (short-term) horizon. Over the central Sahel two members (ten members) are needed for a long-term (short-term) horizon.

  15. Measuring Research Impact in Australia

    Science.gov (United States)

    Gunn, Andrew; Mintrom, Michael

    2018-01-01

    The implementation of the national Research Engagement and Impact Assessment in Australia provides a timely opportunity to review attempts to improve the non-academic impact of academic research. The impact agenda represents a new phase in academic research evaluation and funding, characterised by a heightened need to demonstrate a return on…

  16. Impacts of European drought events

    NARCIS (Netherlands)

    Stahl, Kerstin; Kohn, Irene; Blauhut, Veit; Loon, Van Anne F.; Melsen, Lieke A.; Lanen, van Henny A.J.

    2016-01-01

    Drought is a natural hazard that can cause a wide range of impacts affecting the environment, society, and the economy. Providing an impact assessment and reducing vulnerability to these impacts for regions beyond the local scale, spanning political and sectoral boundaries, requires systematic

  17. How to be impactful [Editorial

    Science.gov (United States)

    William M. Block; Michael L. Morrison

    2007-01-01

    We are being increasingly called upon to judge how impactful the work of various individuals is to the scientific and professional communities. At universities we are asked to judge how impactful the publications of our colleagues are when they come up for promotion and tenure; on faculty search committees we are asked to judge how impactful the various candidates will...

  18. Making An Impact: Shatter Cones

    Science.gov (United States)

    Blank, Lisa M.; Plautz, Michael R.; Crews, Jeffrey W.

    2004-01-01

    In 1990, a group of geologists discovered a large number of shatter cones in southwestern Montana. Shatter cones are a type of metamorphosed rock often found in impact structures (the remains of a crater after a meteor impact and years of Earth activity). Scientists have discovered only 168 impact craters around the world. If rocks could talk,…

  19. Budget impact of vildagliptin

    Directory of Open Access Journals (Sweden)

    Orietta Zaniolo

    2008-09-01

    Full Text Available Introduction: to evaluate the impact on the Italian National Health Service (NHS budget of the recent introduction of the DPP-4 inhibitor vildagliptin in combination treatment for NIDDM patients. Methods: NIDDM patients eligible to vildagliptin treatment were identified and quantified based on approved indications and prevalence data review; adequate alternative strategies were identified; direct medical costs associated with competing strategies were calculated according to national practice and prices (drug acquisition, therapeutic monitoring, cost for managing severe adverse events – severe hypoglycemia events, fractures, new heart failure cases and the NHS budgetary impact was estimated according to market penetration assumptions (base-case: 5% and 10% for the first and second year, respectively. Results: patients estimated eligible for vildagliptin in Italy are about 237,500: pts inadequately controlled with metformin monotherapy (166,500, pts inadequately controlled with sulfonylurea monotherapy and intolerant/contraindicated to metformin (70,200, and those inadequately controlled with thiazolidinedione monotherapy (800. Costing and comparing of the vildagliptin-based and competing strategies revealed differences in both directions, depending on patient subgroup. Assuming uniform penetration among identified patient subgroups, vildagliptin introduction is expected to raise NHS costs by 2,750,000 Euro in the first and by 5,500,000 Euro in the second year, respectively representing 1,6% and 3,2% of the estimated total management cost of this patient population. Conclusions: the introduction of vildagliptin in the treatment of Italian NIDDM patients offers a new therapeutic option for three inadequately controlled NIDDM subpopulations; the financial impact on Italian NHS expenditures depends on patient selection and can be expected not to exceed 2-3% of the currently dedicated budget in the first two years.

  20. Graphene ultracapacitors: structural impacts.

    Science.gov (United States)

    Song, Weixin; Ji, Xiaobo; Deng, Wentao; Chen, Qiyuan; Shen, Chen; Banks, Craig E

    2013-04-07

    The structural effects of graphene on the electrochemical properties of graphene-based ultracapacitors are investigated for the first time, where the competitive impacts resulting from the edge content, specific surface area, edge/basal defects, oxygen-containing groups and metal oxides/surfactant impurities are taken into consideration, demonstrating that not one element, but all are responsible for the final behavior of graphene-based ultracapacitors. This work will be of wide importance to research producing graphene-based energy storage/generation devices.