Kwon, Ji-Sun; Yoon, Jungsoon; Kim, Yeon-Jung; Kang, Kyuho; Woo, Sunje; Jung, Dea-Im; Song, Man Ki; Kim, Eun-Ha; Kwon, Hyeok-Il; Choi, Young Ki; Kim, Jihye; Lee, Jeewon; Yoon, Yeup; Shin, Eui-Cheol; Youn, Jin-Won
2014-08-01
Growing concerns about unpredictable influenza pandemics require a broadly protective vaccine against diverse influenza strains. One of the promising approaches was a T cell-based vaccine, but the narrow breadth of T-cell immunity due to the immunodominance hierarchy established by previous influenza infection and efficacy against only mild challenge condition are important hurdles to overcome. To model T-cell immunodominance hierarchy in humans in an experimental setting, influenza-primed C57BL/6 mice were chosen and boosted with a mixture of vaccinia recombinants, individually expressing consensus sequences from avian, swine, and human isolates of influenza internal proteins. As determined by IFN-γ ELISPOT and polyfunctional cytokine secretion, the vaccinia recombinants of influenza expanded the breadth of T-cell responses to include subdominant and even minor epitopes. Vaccine groups were successfully protected against 100 LD50 challenges with PR/8/34 and highly pathogenic avian influenza H5N1, which contained the identical dominant NP366 epitope. Interestingly, in challenge with pandemic A/Cal/04/2009 containing mutations in the dominant epitope, only the group vaccinated with rVV-NP + PA showed improved protection. Taken together, a vaccinia-based influenza vaccine expressing conserved internal proteins improved the breadth of influenza-specific T-cell immunity and provided heterosubtypic protection against immunologically close as well as distant influenza strains. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Directory of Open Access Journals (Sweden)
Susu Duan
2015-02-01
Full Text Available The recent emergence of a novel H7N9 influenza A virus (IAV causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential protective role of IAV-specific CD8(+ cytotoxic T lymphocyte (CTL memory specific for epitopes conserved between H7N9 and previously encountered IAVs. In the present study, the heterosubtypic immunity generated by prior H9N2 or H1N1 infections significantly, but variably, reduced morbidity and mortality, pulmonary virus load and time to clearance in mice challenged with the H7N9 virus. In all cases, the recall of established CTL memory was characterized by earlier, greater airway infiltration of effectors targeting the conserved or cross-reactive H7N9 IAV peptides; though, depending on the priming IAV, each case was accompanied by distinct CTL epitope immunodominance hierarchies for the prominent K(bPB(1703, D(bPA(224, and D(bNP(366 epitopes. While the presence of conserved, variable, or cross-reactive epitopes between the priming H9N2 and H1N1 and the challenge H7N9 IAVs clearly influenced any change in the immunodominance hierarchy, the changing patterns were not tied solely to epitope conservation. Furthermore, the total size of the IAV-specific memory CTL pool after priming was a better predictor of favorable outcomes than the extent of epitope conservation or secondary CTL expansion. Modifying the size of the memory CTL pool significantly altered its subsequent protective efficacy on disease severity or virus clearance, confirming the important role of heterologous priming. These findings establish that both the protective efficacy of heterosubtypic immunity and CTL immunodominance hierarchies are reflective of the immunological history of the host, a finding that has implications for understanding human CTL responses and the rational design of CTL-mediated vaccines.
Differential immunodominance hierarchy of CD8^{+} T-cell responses in HLA-B*27
DEFF Research Database (Denmark)
Adland, Emily; Hill, Matilda; Lavandier, Nora
2018-01-01
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05- restricted CD8+ T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We stu...
Strong Bayesian evidence for the normal neutrino hierarchy
Energy Technology Data Exchange (ETDEWEB)
Simpson, Fergus; Jimenez, Raul; Verde, Licia [ICCUB, University of Barcelona (UB-IEEC), Marti i Franques 1, Barcelona, 08028 (Spain); Pena-Garay, Carlos, E-mail: fergus2@gmail.com, E-mail: raul.jimenez@icc.ub.edu, E-mail: penagaray@gmail.com, E-mail: liciaverde@icc.ub.edu [I2SysBio, CSIC-UVEG, P.O. 22085, Valencia, 46071 (Spain)
2017-06-01
The configuration of the three neutrino masses can take two forms, known as the normal and inverted hierarchies. We compute the Bayesian evidence associated with these two hierarchies. Previous studies found a mild preference for the normal hierarchy, and this was driven by the asymmetric manner in which cosmological data has confined the available parameter space. Here we identify the presence of a second asymmetry, which is imposed by data from neutrino oscillations. By combining constraints on the squared-mass splittings [1] with the limit on the sum of neutrino masses of Σ m {sub ν} < 0.13 eV [2], and using a minimally informative prior on the masses, we infer odds of 42:1 in favour of the normal hierarchy, which is classified as 'strong' in the Jeffreys' scale. We explore how these odds may evolve in light of higher precision cosmological data, and discuss the implications of this finding with regards to the nature of neutrinos. Finally the individual masses are inferred to be m {sub 1}=3.80{sup +26.2}{sub -3.73}meV; m {sub 2}=8.8{sup +18}{sub -1.2}meV; m {sub 3}=50.4{sup +5.8}{sub -1.2}meV (95% credible intervals).
Richards, Katherine A; DiPiazza, Anthony T; Rattan, Ajitanuj; Knowlden, Zackery A G; Yang, Hongmei; Sant, Andrea J
2018-01-01
One of the major contributions to protective immunity to influenza viruses that is provided by virus-specific CD4 T cells is delivery of effector function to the infected lung. However, there is little known about the selection and breadth of viral epitope-specific CD4 T cells that home to the lung after their initial priming. In this study, using a mouse model of influenza A infection and an unbiased method of epitope identification, the viral epitope-specific CD4 T cells elicited after infection were identified and quantified. We found that a very diverse specificity of CD4 T cells is primed by infection, including epitopes from hemagglutinin, neuraminidase, matrix protein, nucleoprotein, and non-structural protein-1. Using peptide-specific cytokine EliSpots, the diversity and immunodominance hierarchies established in the lung-draining lymph node were compared with specificities of CD4 T cells that home to the lung. Our studies revealed that CD4 T cells of all epitope specificities identified in peripheral lymphoid tissue home back to the lung and that most of these lung-homing cells are localized within the tissue rather than the pulmonary vasculature. There is a striking shift of CD4 T cell functionality that enriches for IFN-γ production as cells are primed in the lymph node, enter the lung vasculature, and finally establish residency in the tissue, but with no apparent shifts in their functional avidity. We conclude that CD4 T cells of broad viral epitope specificity are recruited into the lung after influenza infection, where they then have the opportunity to encounter infected or antigen-bearing antigen-presenting cells.
Strong-Weak CP Hierarchy from Non-Renormalization Theorems
Energy Technology Data Exchange (ETDEWEB)
Hiller, Gudrun
2002-01-28
We point out that the hierarchy between the measured values of the CKM phase and the strong CP phase has a natural origin in supersymmetry with spontaneous CP violation and low energy supersymmetry breaking. The underlying reason is simple and elegant: in supersymmetry the strong CP phase is protected by an exact non-renormalization theorem while the CKM phase is not. We present explicit examples of models which exploit this fact and discuss corrections to the non-renormalization theorem in the presence of supersymmetry breaking. This framework for solving the strong CP problem has generic predictions for the superpartner spectrum, for CP and flavor violation, and predicts a preferred range of values for electric dipole moments.
Large mass hierarchies from strongly-coupled dynamics
Energy Technology Data Exchange (ETDEWEB)
Athenodorou, Andreas [Department of Physics, University of Cyprus,B.O. Box 20537, 1678 Nicosia (Cyprus); Bennett, Ed [Department of Physics, College of Science, Swansea University,Singleton Park, Swansea SA2 8PP (United Kingdom); Kobayashi-Maskawa Institute for the Origin of Particles and the Universe (KMI),Nagoya University,Furo, Chikusa, Nagoya 464-8602 (Japan); Bergner, Georg [Albert Einstein Center for Fundamental Physics, Institute for Theoretical Physics,University of Bern,Sidlerstrasse 5, CH-3012 Bern (Switzerland); Elander, Daniel [National Institute for Theoretical Physics, School of Physics andMandelstam Institute for Theoretical Physics, University of the Witwatersrand,1 Jan Smuts Avenue, Johannesburg, Wits 2050 (South Africa); Lin, C.-J. David [Institute of Physics, National Chiao-Tung University,1001 Ta-Hsueh Road, Hsinchu 30010, Taiwan (China); CNRS, Aix Marseille Université, Université de Toulon, Centre de Physique Théorique,UMR 7332, F-13288 Marseille (France); Lucini, Biagio; Piai, Maurizio [Department of Physics, College of Science, Swansea University,Singleton Park, Swansea SA2 8PP (United Kingdom)
2016-06-20
Besides the Higgs particle discovered in 2012, with mass 125 GeV, recent LHC data show tentative signals for new resonances in diboson as well as diphoton searches at high center-of-mass energies (2 TeV and 750 GeV, respectively). If these signals are confirmed (or other new resonances are discovered at the TeV scale), the large hierarchies between masses of new bosons require a dynamical explanation. Motivated by these tentative signals of new physics, we investigate the theoretical possibility that large hierarchies in the masses of glueballs could arise dynamically in new strongly-coupled gauge theories extending the standard model of particle physics. We study lattice data on non-Abelian gauge theories in the (near-)conformal regime as well as a simple toy model in the context of gauge/gravity dualities. We focus our attention on the ratio R between the mass of the lightest spin-2 and spin-0 resonances, that for technical reasons is a particularly convenient and clean observable to study. For models in which (non-perturbative) large anomalous dimensions arise dynamically, we show indications that this mass ratio can be large, with R>5. Moreover, our results suggest that R might be related to universal properties of the IR fixed point. Our findings provide an interesting step towards understanding large mass ratios in the non-perturbative regime of quantum field theories with (near) IR conformal behaviour.
International Nuclear Information System (INIS)
Caldirola, P.; Recami, E.
1978-01-01
By assuming covariance of physical laws under (discrete) dilatations, strong and gravitational interactions have been described in a unified way. In terms of the (additional, discrete) ''dilatational'' degree of freedom, our cosmos as well as hadrons can be considered as different states of the same system, or rather as similar systems. Moreover, a discrete hierarchy can be defined of ''universes'' which are governed by force fields with strengths inversely proportional to the ''universe'' radii. Inside each ''universe'' an equivalence principle holds, so that its characteristic field can be geometrized there. It is thus easy to derive a whole ''numerology'', i.e. relations among numbers analogous to the so-called Weyl-Eddington-Dirac ''large numbers''. For instance, the ''Planck mass'' happens to be nothing but the (average) magnitude of the strong charge of the hadron quarks. However, our ''numerology'' connects the (gravitational) macrocosmos with the (strong) microcosmos, rather than with the electromagnetic ones (as, e.g., in Dirac's version). Einstein-type scaled equations (with ''cosmological'' term) are suggested for the hadron interior, which - incidentally - yield a (classical) quark confinement in a very natural way and are compatible with the ''asymptotic freedom''. At last, within a ''bi-scale'' theory, further equations are proposed that provide a priori a classical field theory of strong interactions (between different hadrons). The relevant sections are 5.2, 7 and 8. (author)
Directory of Open Access Journals (Sweden)
Dhaker Kroumi
2015-09-01
Full Text Available In this paper, we deduce a condition for a strategy S1 to be more abundant on average at equilibrium under weak selection than another strategy S2 in a population structured into a finite number of colonies of fixed proportions as the population size tends to infinity. It is assumed that one individual reproduces at a time with some probability depending on the payoff received in pairwise interactions within colonies and between colonies and that the offspring replaces one individual chosen at random in the colony into which the offspring migrates. It is shown that an expected weighted average equilibrium frequency of S1 under weak symmetric strategy mutation between S1 and S2 is increased by weak selection if an expected weighted payoff of S1 near neutrality exceeds the corresponding expected weighted payoff of S2. The weights are given in terms of reproductive values of individuals in the different colonies in the neutral model. This condition for S1 to be favoured by weak selection is obtained from a strong migration limit of the genealogical process under neutrality for a sample of individuals, which is proven using a two-time scale argument. The condition is applied to games between individuals in colonies with linear or cyclic dominance and between individuals belonging to groups represented by subsets of a given set.
Immunodomination during peripheral vaccinia virus infection.
Directory of Open Access Journals (Sweden)
Leon C W Lin
Full Text Available Immunodominance is a fundamental property of CD8(+ T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV infection, but only a few epitopes were examined and no mechanism was provided. We re-visited this issue, examining a panel of 15 VACV epitopes and four routes, namely intradermal (i.d., subcutaneous (s.c., intraperitoneal (i.p. and intravenous (i.v. injection. We found that immunodominance is sharpened following peripheral routes of infection (i.d. and s.c. compared with those that allow systemic virus dissemination (i.p. and i.v.. This increased immunodominance was demonstrated with native epitopes of VACV and with herpes simplex virus glycoprotein B when expressed from VACV. Responses to some subdominant epitopes were altered by as much as fourfold. Tracking of virus, examination of priming sites, and experiments restricting virus spread showed that priming of CD8(+ T cells in the spleen was necessary, but not sufficient to broaden responses. Further, we directly demonstrated that immunodomination occurs more readily when priming is mainly in lymph nodes. Finally, we were able to reduce immunodominance after i.d., but not i.p. infection, using a VACV expressing the costimulators CD80 (B7-1 and CD86 (B7-2, which is notable because VACV-based vaccines incorporating these molecules are in clinical trials. Taken together, our data indicate that resources for CD8(+ T cell priming are limiting in local draining lymph nodes, leading to greater immunodomination. Further, we provide evidence that costimulation can be a limiting factor that contributes to immunodomination. These results shed light on a possible mechanism of immunodomination and highlight the need to consider multiple epitopes across the spectrum of immunogenicities in studies aimed at understanding CD8(+ T cell immunity to viruses.
Directory of Open Access Journals (Sweden)
Jens Dinter
2015-03-01
Full Text Available Dendritic cells (DCs and macrophages (Møs internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8⁺ T cells (CTL. However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorly defined. Here, we studied the processing and cross-presentation of dominant and subdominant HIV-1 Gag-derived epitopes and HLA-restricted mutants by monocyte-derived DCs and Møs. The cross-presentation of HIV proteins by both DCs and Møs led to higher CTL responses specific for immunodominant epitopes. The low CTL responses to subdominant epitopes were increased by pretreatment of target cells with peptidase inhibitors, suggestive of higher intracellular degradation of the corresponding peptides. Using DC and Mø cell extracts as a source of cytosolic, endosomal or lysosomal proteases to degrade long HIV peptides, we identified by mass spectrometry cell-specific and compartment-specific degradation patterns, which favored the production of peptides containing immunodominant epitopes in all compartments. The intracellular stability of optimal HIV-1 epitopes prior to loading onto MHC was highly variable and sequence-dependent in all compartments, and followed CTL hierarchy with immunodominant epitopes presenting higher stability rates. Common HLA-associated mutations in a dominant epitope appearing during acute HIV infection modified the degradation patterns of long HIV peptides, reduced intracellular stability and epitope production in cross-presentation-competent cell compartments, showing that impaired epitope production in the cross-presentation pathway contributes to immune escape. These findings highlight the contribution of degradation patterns in the cross-presentation pathway to HIV immunodominance and provide the first demonstration of immune escape affecting epitope cross-presentation.
DEFF Research Database (Denmark)
Kristiansen, Marianne; Bloch-Poulsen, Jørgen
2016-01-01
projects works in the interface between communication and organisation. Third, the methodological purpose is to show that handling of these participatory hierarchies ought to become a goal in OAR projects to be included along with producing practical and theoretical results. The article argues...
New integrable lattice hierarchies
International Nuclear Information System (INIS)
Pickering, Andrew; Zhu Zuonong
2006-01-01
In this Letter we give a new integrable four-field lattice hierarchy, associated to a new discrete spectral problem. We obtain our hierarchy as the compatibility condition of this spectral problem and an associated equation, constructed herein, for the time-evolution of eigenfunctions. We consider reductions of our hierarchy, which also of course admit discrete zero curvature representations, in detail. We find that our hierarchy includes many well-known integrable hierarchies as special cases, including the Toda lattice hierarchy, the modified Toda lattice hierarchy, the relativistic Toda lattice hierarchy, and the Volterra lattice hierarchy. We also obtain here a new integrable two-field lattice hierarchy, to which we give the name of Suris lattice hierarchy, since the first equation of this hierarchy has previously been given by Suris. The Hamiltonian structure of the Suris lattice hierarchy is obtained by means of a trace identity formula
Ghosh, Moumita; Solanki, Ashish K; Roy, Koushik; Dhoke, Reema R; Ashish; Roy, Syamal
2013-09-23
We investigated how the processing of a given antigen by antigen presenting cells (APC) is dictated by the conformation of the antigen and how this governs the immunodominance hierarchy. To address the question, a known immunodominant sequence of bacteriophage lambda repressor N-terminal sequence 12-26 [λR(12-26)] was engineered at the N and C termini of a heterologous leishmanial protein, Kinetoplastid membrane protein-11 (KMP-11); the resulting proteins were defined as N-KMP-11 and C-KMP-11 respectively. The presence of λR(12-26) in N-KMP-11 and C-KMP-11 was established by western blot analysis with antibody to λR(12-26) peptide. N-KMP-11 but not C-KMP-11 could stimulate the anti λR(12-26) T-cell clonal population very efficiently in the presence of APCs. Priming of BALB/c mice with N-KMP-11 or C-KMP-11 generated similar levels of anti-KMP-11 IgG, but anti-λR(12-26) specific IgG was observed only upon priming with N-KMP-11. Interestingly, uptake of both N-KMP-11 and C-KMP-11 by APCs was similar but catabolism of N-KMP-11 but not C-KMP-11 was biphasic and fast at the initial time point. Kratky plots of small angle X-ray scattering showed that while N-KMP-11 adopts flexible Gaussian type of topology, C-KMP-11 prefers Globular nature. To show that KMP-11 is not unique as a carrier protein, an epitope (SPITBTNLBTMBK) of Plasmodium yoelii (PY) apical membrane protein 1[AMA-1 (136-148)], is placed at the C and N terminals of a dominant T-cell epitope of ovalbumin protein OVA(323-339) and the resulting peptides are defined as PY-OVA and OVA-PY respectively. Interestingly, only OVA-PY could stimulate anti-OVA T-cells and produce IgG response upon priming of BALB/c mice with it. Thus for rational design of peptide vaccine it is important to place the dominant epitope appropriately in the context of the carrier protein. Copyright © 2013 Elsevier Ltd. All rights reserved.
International Nuclear Information System (INIS)
Senatore, Leonardo
2006-01-01
We study a recently proposed mechanism to solve the hierarchy problem in the context of the landscape, where the solution of the hierarchy problem is connected to the requirement of having baryons in our Universe via electroweak baryogenesis. The phase transition is triggered by the fermion condensation of a new gauge sector which becomes strong at a scale Λ determined by dimensional transmutation, and it is mediated to the standard model by a new singlet field. In a 'friendly' neighborhood of the landscape, where only the relevant operators are ''scanned'' among the vacua, baryogenesis is effective only if the Higgs mass m h is comparable to this low scale Λ, forcing m h ∼Λ, and solving the hierarchy problem. A new CP violating phase is needed coupling the new singlet and the Higgs field to new matter fields. We study the constraints on this model given by baryogenesis and by the electron electric dipole moment (EDM), and we briefly comment on gauge coupling unification and on dark matter relic abundance. We find that next generation experiments on the EDM will be sensitive to essentially the entire viable region of the parameter space, so that absence of a signal would effectively rule out the model
Liu, Lianrui; Huang, Xinmei; Liu, Jianhua; Li, Wenyu; Ji, Yihong; Tian, Di; Tian, Lu; Yang, Xinchao; Xu, Lixin; Yan, Ruofeng; Li, Xiangrui; Song, Xiaokai
2017-05-23
Clinical chicken coccidiosis is mostly caused by simultaneous infection of several Eimeria species, and host immunity against Eimeria is species-specific. It is urgent to identify common immunodominant antigen of Eimeria for developing multivalent anticoccidial vaccines. In this study, sporozoite proteins of Eimeria tenella, Eimeria acervulina and Eimeria maxima were analyzed by two-dimensional electrophoresis (2DE). Western bot analysis was performed on the yielded 2DE gel using antisera of E. tenella E. acervulina and E. maxima respectively. Next, the detected immunodominant spots were identified by comparing the data from MALDI-TOF-MS/MS with available databases. Finally, Eimeria common antigens were identified by comparing amino acid sequence between the three Eimeria species. The results showed that analysis by 2DE of sporozoite proteins detected 629, 626 and 632 protein spots from E. tenella, E. acervulina and E. maxima respectively. Western bot analysis revealed 50 (E. tenella), 64 (E. acervulina) and 57 (E. maxima) immunodominant spots from the sporozoite 2DE gels of the three Eimeria species. The immunodominant spots were identified as 33, 27 and 25 immunodominant antigens of E. tenella, E. acervulina and E. maxima respectively. Fifty-four immunodominant proteins were identified as 18 ortholog proteins among the three Eimeria species. Finally, 5 of the 18 ortholog proteins were identified as common immunodominant antigens including elongation factor 2 (EF-2), 14-3-3 protein, ubiquitin-conjugating enzyme domain-containing protein (UCE) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In conclusion, our results not only provide Eimeria sporozoite immunodominant antigen map and additional immunodominant antigens, but also common immunodominant antigens for developing multivalent anticoccidial vaccines.
International Nuclear Information System (INIS)
Tutiya, Y.; Satsuma, J.
2003-01-01
In this Letter, we present a new hierarchy which includes the intermediate long wave (ILW) equation at the lowest order. This hierarchy is thought to be a novel reduction of the 1st modified KP type hierarchy. The framework of our investigation is Sato theory
Resolution of ranking hierarchies in directed networks
Barucca, Paolo; Lillo, Fabrizio
2018-01-01
Identifying hierarchies and rankings of nodes in directed graphs is fundamental in many applications such as social network analysis, biology, economics, and finance. A recently proposed method identifies the hierarchy by finding the ordered partition of nodes which minimises a score function, termed agony. This function penalises the links violating the hierarchy in a way depending on the strength of the violation. To investigate the resolution of ranking hierarchies we introduce an ensemble of random graphs, the Ranked Stochastic Block Model. We find that agony may fail to identify hierarchies when the structure is not strong enough and the size of the classes is small with respect to the whole network. We analytically characterise the resolution threshold and we show that an iterated version of agony can partly overcome this resolution limit. PMID:29394278
Directory of Open Access Journals (Sweden)
Hui-Jie Yang
Full Text Available Vaccination strategies for Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA infections have attracted much research attention. Recent efforts have been made to select manganese transport protein C, or manganese binding surface lipoprotein C (MntC, which is a metal ion associated with pathogen nutrition uptake, as potential candidates for an S. aureus vaccine. Although protective humoral immune responses to MntC are well-characterised, much less is known about detailed MntC-specific B cell epitope mapping and particularly epitope vaccines, which are less-time consuming and more convenient. In this study, we generated a recombinant protein rMntC which induced strong antibody response when used for immunisation with CFA/IFA adjuvant. On the basis of the results, linear B cell epitopes within MntC were finely mapped using a series of overlapping synthetic peptides. Further studies indicate that MntC113-136, MntC209-232, and MntC263-286 might be the original linear B-cell immune dominant epitope of MntC, furthermore, three-dimensional (3-d crystal structure results indicate that the three immunodominant epitopes were displayed on the surface of the MntC antigen. On the basis of immunodominant MntC113-136, MntC209-232, and MntC263-286 peptides, the epitope vaccine for S. aureus induces a high antibody level which is biased to TH2 and provides effective immune protection and strong opsonophagocytic killing activity in vitro against MRSA infection. In summary, the study provides strong proof of the optimisation of MRSA B cell epitope vaccine designs and their use, which was based on the MntC antigen in the development of an MRSA vaccine.
Measuring Maslow's hierarchy of needs.
Lester, David
2013-08-01
Two scales have been proposed to measure Maslow's hierarchy of needs in college students, one by Lester (1990) and one by Strong and Fiebert (1987). In a sample of 51 college students, scores on the corresponding scales for the five needs did not correlate significantly and positively, except for the measures of physiological needs. Furthermore, there was limited support for Maslow's hypothesis that need deprivation would predict psychopathology (specifically, mania and depression).
DEFF Research Database (Denmark)
Ernst, Erik
2003-01-01
This paper introduces the notion of higher-order inheritance hierarchies. They are useful because they provide well-known benefits of object-orientation at the level of entire hierarchies-benefits which are not available with current approaches. Three facets must be adressed: First, it must be po...
The Analytical Hierarchy Process
DEFF Research Database (Denmark)
Barfod, Michael Bruhn
2007-01-01
The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use.......The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use....
Interaction of an immunodominant epitope with Ia molecules in T-cell activation
DEFF Research Database (Denmark)
Adorini, L; Sette, A; Buus, S
1988-01-01
The amino acid sequence corresponding to residues 107-116 of hen egg-white lysozyme (HEL) has been identified as containing an immunodominant T-cell epitope recognized in association with the I-Ed molecule. The immunodominance of this epitope in HEL-primed H-2d mice was demonstrated by analysis o......-120)-peptide was found to be immunogenic in H-2d mice. Thus, a single semiconservative substitution drastically reduces binding capacity and abolishes immunogenicity, suggesting that a strict correlation exists between binding of a peptide to Ia molecules and its immunogenicity....
Critical constraints on chiral hierarchies
International Nuclear Information System (INIS)
Chivukula, R.S.; Golden, M.; Simmons, E.H.
1993-01-01
Critical dynamics constrains models of dynamical electroweak symmetry breaking in which the scale of high-energy physics is far above 1 TeV. A big hierarchy requires the high-energy theory to have a second-order chiral phase transition, near which the theory is described by a low-energy effective Lagrangian with composite ''Higgs'' scalars. As scalar theories with more than one Φ 4 coupling can have a Coleman-Weinberg instability and a first-order transition, such dynamical EWSB models cannot always support a large hierarchy. If the large-N c Nambu--Jona-Lasinio model is a good approximation to the top-condensate and strong extended technicolor models, they will not produce acceptable EWSB
Leavitt, Harold J
2003-03-01
Hardly anyone has a good word to say about hierarchies. Academics, consultants, and management gurus regularly forecast their imminent replacement because hierarchies--even when populated by considerate and intelligent people--can be cruel and stupid. They routinely transform motivated and loyal employees into disaffected Dilberts. It's no wonder that we continue to search for more humane and productive alternatives to them. Yet the intensity with which we struggle against hierarchies only serves to highlight their durability. Hierarchy, it seems, may be intrinsic not only to the natural world but also to our own natures. In this article, organizational behavior expert Harold J. Leavitt presents neither a defense of human hierarchies nor another attack on them. Instead, he offers a reality check, a reminder that hierarchy remains the basic structure of most, if not all, large, ongoing human organizations. That's because although they are often depicted as being out of date, hierarchies have proved to be extraordinarily adaptive. Over the past 50 years, for example, they have co-opted the three major managerial movements--human relations, analytic management, and communities of practice. Hierarchies also persist because they deliver real practical and psychological value, and they fulfill our deep need for order and security. Despite the good they may do, hierarchies are inevitably authoritarian. That authoritarianism shows up in all kinds of ways and influences everything in organizations, particularly communication. In multilevel organizations, for instance, messages get distorted as they travel up and down the ladder of command. Self-protection and self-interest weigh in, and relevant information is lost as messages make stops along the route. Sensitive leaders take steps to make speaking the truth as painless as possible. But it never is in organizations, because authoritarianism is an immutable element of hierarchy.
Solving the wrong hierarchy problem
International Nuclear Information System (INIS)
Blinov, Nikita; Hook, Anson
2016-01-01
Many theories require augmenting the Standard Model with additional scalar fields with large order one couplings. We present a new solution to the hierarchy problem for these scalar fields. We explore parity- and Z_2-symmetric theories where the Standard Model Higgs potential has two vacua. The parity or Z_2 copy of the Higgs lives in the minimum far from the origin while our Higgs occupies the minimum near the origin of the potential. This approach results in a theory with multiple light scalar fields but with only a single hierarchy problem, since the bare mass is tied to the Higgs mass by a discrete symmetry. The new scalar does not have a new hierarchy problem associated with it because its expectation value and mass are generated by dimensional transmutation of the scalar quartic coupling. The location of the second Higgs minimum is not a free parameter, but is rather a function of the matter content of the theory. As a result, these theories are extremely predictive. We develop this idea in the context of a solution to the strong CP problem. Lastly, we show this mechanism postdicts the top Yukawa to be within 1σ of the currently measured value and predicts scalar color octets with masses in the range 9-200 TeV
A hierarchy of Liouville integrable discrete Hamiltonian equations
Energy Technology Data Exchange (ETDEWEB)
Xu Xixiang [College of Science, Shandong University of Science and Technology, Qingdao 266510 (China)], E-mail: xixiang_xu@yahoo.com.cn
2008-05-12
Based on a discrete four-by-four matrix spectral problem, a hierarchy of Lax integrable lattice equations with two potentials is derived. Two Hamiltonian forms are constructed for each lattice equation in the resulting hierarchy by means of the discrete variational identity. A strong symmetry operator of the resulting hierarchy is given. Finally, it is shown that the resulting lattice equations are all Liouville integrable discrete Hamiltonian systems.
Satoh, Ryoichi; Furukawa, Tomoko; Kotake, Masako; Takano, Tomomi; Motokawa, Kenji; Gemma, Tsuyoshi; Watanabe, Rie; Arai, Setsuo; Hohdatsu, Tsutomu
2011-02-17
The antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection has been recognized in experimentally infected cats, and cellular immunity is considered to play an important role in preventing the onset of feline infectious peritonitis (FIP). In the present study, we synthesized eighty-one kinds of peptides derived from the spike (S)2 domain of type I FIPV KU-2 strain, the S2 domain of type II FIPV 79-1146 strain, and the nucleocapcid (N) protein of FIPV KU-2 strain. To detect the T helper (Th)1 epitope, peripheral blood mononuclear cells (PBMCs) obtained from FIPV-infected cats were cultured with each peptide, and Th1-type immune responses were measured using feline interferon (fIFN)-γ production as an index. To detect the linear immunodominant antibody-binding epitope, we investigated the reactivity of plasma collected from FIPV-infected cats against each peptide by ELISA. Four and 2 peptides containing Th1 epitopes were identified in the heptad repeat (HR)1 and inter-helical (IH) regions of the S2 domain of type I FIPV, respectively, and these were located on the N-terminal side of the regions. In the S2 domain of type II FIPV, 2, 3, and 2 peptides containing Th1 epitopes were identified in the HR1, IH, and HR2 regions, respectively, and these were mainly located on the C-terminal side of the regions. In the S2 domain of type I FIPV, 3 and 7 peptides containing linear immunodominant antibody-binding epitopes were identified in the IH and HR2 regions, respectively. In the S2 domain of type II FIPV, 4 peptides containing linear immunodominant antibody-binding epitopes were identified in the HR2 region. The Th1 epitopes in the S2 domain of type I and II FIPV were located in different regions, but the linear immunodominant antibody-binding epitopes were mostly located in the HR2 region. Eight peptides containing Th1 epitopes were identified in N protein, and 3 peptides derived from residues 81 to 100 and 137 to 164 showed strong
Integral hierarchies and percolation
International Nuclear Information System (INIS)
Klein, W.; Stell, G.
1985-01-01
For a variation of the Potts model which has been shown to describe continuum percolation, we derive a hierarchy of integral equations of Kirkwood-Salsburg type. The distribution functions which are the solutions of this hierarchy can be simply related to the connectedness functions in continuum percolation. From this hierarchy a second set of equations is derived from which the connectedness functions can be obtained directly. This approach is extremely useful when investigating properties of systems far from the percolation transition. These hierarchies are solved exactly in the mean-field (Kac-Baker) limit and possible implications for cluster growth are discussed. The relation between the Potts model for continuum percolation and the Widom-Rowlinson model is also noted
Takano, Tomomi; Morioka, Hiroyuki; Gomi, Kohji; Tomizawa, Keisuke; Doki, Tomoyoshi; Hohdatsu, Tsutomu
2014-04-01
Feline infectious peritonitis virus (FIP virus: FIPV) causes a fatal disease in wild and domestic cats. The development of an FIP-preventive vaccine requires an antigen that does not induce antibody-dependent enhancement, and T helper (Th)1 activity plays an important role in protect against FIPV infection. In the present study, we identified synthetic peptides including Th1 and a linear immunodominant antibody-binding epitope in the S1 domain and M protein of FIPV. We also identified peptides that strongly induce Th1 activity from those derived from the structural proteins (S, M, and N proteins) of FIPV based on this and previous studies (Satoh et al. [19]). No Th1 epitope-containing peptide was identified in the peptides derived from the S1 domain of type I FIPV. In contrast, 7 Th1 epitope-containing peptides were identified in the S1 domain of type II FIPV, and no linear immunodominant antibody-binding epitope was contained in any of these peptides. Eleven Th1 epitope-containing peptides common to each serotype were identified in the M protein-derived peptides, and 2 peptides (M-11 and M-12) contained the linear immunodominant antibody-binding epitope. Of the peptides derived from the S, M, and N proteins of FIPV, those that induced significantly stronger Th1 activity than that of the FIPV antigen were rescreened, and 4 peptides were identified. When 3 of these peptides (M-9, I-S2-15, and II-S1-24) were selected and administered with CpG-ODNs to SPF cats, M-9 and II-S1-24 induced Th1 activity. Our results may provide important information for the development of a peptide-based vaccine against FIPV infection. Copyright © 2014 Elsevier Ltd. All rights reserved.
Tibély, Gergely; Pollner, Péter; Vicsek, Tamás; Palla, Gergely
2013-01-01
Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the “flat” organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of search
Directory of Open Access Journals (Sweden)
Gergely Tibély
Full Text Available Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the "flat" organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of
Tibély, Gergely; Pollner, Péter; Vicsek, Tamás; Palla, Gergely
2013-01-01
Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the "flat" organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of search. Moreover
International Nuclear Information System (INIS)
Natale, A.A.; Shellard, R.C.
1981-01-01
The problem of gauge hierarchy in Grand Unified Theories using a toy model with O(N) symmetry is discussed. It is shown that there is no escape to the unnatural adjustment of coupling constants, made only after the computation of several orders in perturbation theory is performed. The propositions of some authors on ways to overcome the gauge hierarchy problem are commented. (Author) [pt
Integrable Hierarchies and Dispersionless Limit
Takasaki, Kanehisa; Takebe, Takashi
1994-01-01
Analogues of the KP and the Toda lattice hierarchy called dispersionless KP and Toda hierarchy are studied. Dressing operations in the dispersionless hierarchies are introduced as a canonical transformation, quantization of which is dressing operators of the ordinary KP and Toda hierarchy. An alternative construction of general solutions of the ordinary KP and Toda hierarchy is given as twistor construction which is quatization of the similar construction of solutions of dispersionless hierar...
Jaques, E
1990-01-01
Hierarchy has not had its day. After 3,000 years as the preferred structure for large organizations, managerial hierarchy is still the most natural and effective organizational form that a big company can employ. Now, as in the past, the key to organizational success is individual accountability, and hierarchy preserves unambiguous accountability for getting work done. Unfortunately, hierarchy is widely misunderstood and abused. Pay grades are confused with real layers of responsibility, for example, and incompetent bosses abound. As a result, many experts now urge us to adopt group-oriented or "flat" structures. But groups are never held accountable as groups for what they do or fail to do, and groups don't have careers. The proper use of hierarchy derives from the nature of work. As organizational tasks range from simple to very complex, there are sharp jumps in the level of difficulty and responsibility. Surprisingly, people in hundreds of companies in dozens of countries agree on where these jumps take place. They are tied to an objective measure-the time span of the longest task or program assigned to each managerial role-and they occur at 3 months, 1 year, 2 years, 5 years, 10 years, and 20 years. As the time span increases, so does the level of experience, knowledge, and mental stamina required to do the work. This increasing level of mental capacity lets companies put people in jobs they can do, it allows managers to add value to the work of their subordinates, it creates hierarchical layers acceptable to everyone in the organization, and it allows employees to be evaluated by people they accept as organizational superiors. Best of all, understanding hierarchy allows organizations to set up hierarchies with no more than seven layers-often fewer-and to know what the structure is good for and how it ought to perform.
New solutions to the hierarchy problem
International Nuclear Information System (INIS)
Burdman, Gustavo
2007-01-01
After summarizing the status of the Standard Model, we focus on the Hierarchy Problem and why we believe this strongly suggests the need for new physics at the TeV scale. We then concentrate on theories with extra dimensions and their possible manifestations at this scale. (author)
Rethinking the waste hierarchy
Energy Technology Data Exchange (ETDEWEB)
Rasmussen, C; Vigsoe, D [eds.
2005-03-01
There is an increasing need to couple environmental and economic considerations within waste management. Consumers and companies alike generate ever more waste. The waste-policy challenges of the future lie in decoupling growth in waste generation from growth in consumption, and in setting priorities for the waste management. This report discusses the criteria for deciding priorities for waste management methods, and questions the current principles of EU waste policies. The basis for the discussion is the so-called waste hierarchy which has dominated the waste policy in the EU since the mid-1970s. The waste hierarchy ranks possible methods of waste management. According to the waste hierarchy, the very best solution is to reduce the amount of waste. After that, reuse is preferred to recycling which, in turn, is preferred to incineration. Disposal at a landfill is the least favourable solution. (BA)
DEFF Research Database (Denmark)
Dobrajska, Magdalena; Billinger, Stephan; Karim, Samina
2015-01-01
We investigate trade-offs associated with delegating authority over multiple interrelated decisions in a complex task structure. The empirical setting is a business process of a global Fortune 50 firm. The firm decentralized its organization and redefined decision authority across organizational......-relevant knowledge, the matching of required knowledge and managers’ expertise, and information processing intensity affect (a) the occurrence of delegation and, (b) if delegation occurs, how far down the organizational hierarchy authority is delegated. We discuss how these findings complement existing theories...... on delegation by providing insights into when and how interrelated decisions are delegated across multiple levels of an organizational hierarchy....
International Nuclear Information System (INIS)
Natale, A.A.
The problem of gauge hierarchy in a O(N) model is discussed. It is shown the existence of an upper bound for the hierarchy of order α- 1 / 2 , as proposed by Gildener. This same constraint appears when the breaking is made by the radiative corrections in a scheme elaborated by Weinberg. It is found that fine tunning or redefinition of coupling constants to improve hieracrchy, as proposed in several papers, cannot be done before the calculation of higher order contributions to the effective potential. (Author) [pt
Shedding of the immunodominant P20 surface antigen of Eimeria bovis sporozoites.
Speer, C A; Whitmire, W M
1989-01-01
P20 is an immunodominant surface antigen of Eimeria bovis sporozoites. As parasites underwent merogony within cultured bovine monocytes and Madin-Darby bovine kidney (MDBK) cells, P20 appeared to be shed gradually by meronts and was absent in type 1 and 2 first-generation merozoites. Meronts of E. bovis appeared to shed P20 into the parasitophorous vacuole of bovine monocytes, whereas MDBK cells evidently released P20 into the culture medium or destroyed its antigenic determinant.
On the Hierarchy of Neutrino Masses
International Nuclear Information System (INIS)
Jezabek, M.; Urban, P.
2002-01-01
We present a model of neutrino masses combining the seesaw mechanism and strong Dirac mass hierarchy and at the same time exhibiting a significantly reduced hierarchy at the level of active neutrino masses. The heavy Majorana masses are assumed to be degenerate. The suppression of the hierarchy is due to a symmetric and unitary operator R whose role is discussed. The model gives realistic mixing and mass spectrum. The mixing of atmospheric neutrinos is attributed to the charged lepton sector whereas the mixing of solar neutrinos is due to the neutrino sector. Small U e3 is a consequence of the model. The masses of the active neutrinos are given by μ 3 ≅ √(Δm 2 O ) and μ 1 /μ 2 = ≅ tan 2 (θ O ). (author)
Materials with structural hierarchy
Lakes, Roderic
1993-01-01
The role of structural hierarchy in determining bulk material properties is examined. Dense hierarchical materials are discussed, including composites and polycrystals, polymers, and biological materials. Hierarchical cellular materials are considered, including cellular solids and the prediction of strength and stiffness in hierarchical cellular materials.
Toda hierarchies and their applications
Takasaki, Kanehisa
2018-05-01
The 2D Toda hierarchy occupies a central position in the family of integrable hierarchies of the Toda type. The 1D Toda hierarchy and the Ablowitz–Ladik (aka relativistic Toda) hierarchy can be derived from the 2D Toda hierarchy as reductions. These integrable hierarchies have been applied to various problems of mathematics and mathematical physics since 1990s. A recent example is a series of studies on models of statistical mechanics called the melting crystal model. This research has revealed that the aforementioned two reductions of the 2D Toda hierarchy underlie two different melting crystal models. Technical clues are a fermionic realization of the quantum torus algebra, special algebraic relations therein called shift symmetries, and a matrix factorization problem. The two melting crystal models thus exhibit remarkable similarity with the Hermitian and unitary matrix models for which the two reductions of the 2D Toda hierarchy play the role of fundamental integrable structures.
Multiple Hierarchies and Organizational Control
Evans, Peter B.
1975-01-01
Uses a control-loss model to explore the effects of multiple channels in formal organizations, and presents an argument for the superior control properties of dual hierarchies. Two variant forms of multiple hierarchies are considered. (Author)
Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
DEFF Research Database (Denmark)
Tenzer, Stefan; Wee, Edmund; Burgevin, Anne
2009-01-01
-associated antigen proteins p17 and p24 correlated with epitope abundance, which was strongly influenced by proteasomal digestion profiles, affinity for the transporter protein TAP, and trimming mediated by the endoplasmatic reticulum aminopeptidase ERAAP, and was moderately influenced by HLA affinity. Structural...
Functional representations of integrable hierarchies
International Nuclear Information System (INIS)
Dimakis, Aristophanes; Mueller-Hoissen, Folkert
2006-01-01
We consider a general framework for integrable hierarchies in Lax form and derive certain universal equations from which 'functional representations' of particular hierarchies (such as KP, discrete KP, mKP, AKNS), i.e. formulations in terms of functional equations, are systematically and quite easily obtained. The formalism genuinely applies to hierarchies where the dependent variables live in a noncommutative (typically matrix) algebra. The obtained functional representations can be understood as 'noncommutative' analogues of 'Fay identities' for the KP hierarchy
Ansatz for dynamical hierarchies
DEFF Research Database (Denmark)
Rasmussen, S.; Baas, N.A.; Mayer, B.
2001-01-01
Complex, robust functionalities can be generated naturally in at least two ways: by the assembly of structures and by the evolution of structures. This work is concerned with spontaneous formation of structures. We define the notion of dynamical hierarchies in natural systems and show...... the importance of this particular kind of organization for living systems. We then define a framework that enables us to formulate, investigate, and manipulate such dynamical hierarchies. This framework allows us to simultaneously investigate different levels of description together with them interrelationship...... three. Formulating this system as a simple two-dimensional molecular dynamics (MD) lattice gas allows us within one dynamical system to demonstrate the successive emergence of two higher levels (three levels all together) of robust structures with associated properties. Second, we demonstrate how...
Boolean Operations, Joins, and the Extended Low Hierarchy
Hemaspaandra, Lane A.; Jiang, Zhigen; Rothe, Joerg; Watanabe, Osamu
1999-01-01
We prove that the join of two sets may actually fall into a lower level of the extended low hierarchy than either of the sets. In particular, there exist sets that are not in the second level of the extended low hierarchy, EL_2, yet their join is in EL_2. That is, in terms of extended lowness, the join operator can lower complexity. Since in a strong intuitive sense the join does not lower complexity, our result suggests that the extended low hierarchy is unnatural as a complexity measure. We...
Extension of noncommutative soliton hierarchies
International Nuclear Information System (INIS)
Dimakis, Aristophanes; Mueller-Hoissen, Folkert
2004-01-01
A linear system, which generates a Moyal-deformed two-dimensional soliton equation as an integrability condition, can be extended to a three-dimensional linear system, treating the deformation parameter as an additional coordinate. The supplementary integrability conditions result in a first-order differential equation with respect to the deformation parameter, the flow of which commutes with the flow of the deformed soliton equation. In this way, a deformed soliton hierarchy can be extended to a bigger hierarchy by including the corresponding deformation equations. We prove the extended hierarchy properties for the deformed AKNS hierarchy, and specialize to the cases of deformed NLS, KdV and mKdV hierarchies. Corresponding results are also obtained for the deformed KP hierarchy. A deformation equation determines a kind of Seiberg-Witten map from classical solutions to solutions of the respective 'noncommutative' deformed equation
Consultancy services and the urban hierarchy in Western Europe
P W Daniels; J H J Van Dinteren; M C Monnayer
1992-01-01
A cross-national survey of the relationship between the evolving organisation and structure of consultancy service enterprises and the urban hierarchy in Europe has been undertaken. Primate cities in Europe are still the preeminent foci for business services performing strong national and international control. The relationship between markets for consultancy services and the urban hierarchy is complex, but it is possible to suggest a typology of firms on the basis of client characteristics a...
T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus
Bovay, Amandine; Zoete, Vincent; Dolton, Garry; Bulek, Anna M.; Cole, David K.; Rizkallah, Pierre J.; Fuller, Anna; Beck, Konrad; Michielin, Olivier; Speiser, Daniel E.; Sewell, Andrew K.; Fuertes Marraco, Silvia A.
2018-01-01
The repertoire of human αβ T-cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen-specific T cells and/or exhibit bias toward a TCR gene segment. Here, we studied the TCR repertoire of the HLA-A*0201-restricted epitope LLWNGPMAV (hereafter, A2/LLW) from Yellow Fever virus, which generates an immunodominant CD8 javax.xml.bind.JAXBElement@714aac...
Determining the neutrino mass hierarchy with cosmology
International Nuclear Information System (INIS)
De Bernardis, Francesco; Kitching, Thomas D.; Heavens, Alan; Melchiorri, Alessandro
2009-01-01
The combination of current large-scale structure and cosmic microwave background anisotropies data can place strong constraints on the sum of the neutrino masses. Here we show that future cosmic shear experiments, in combination with cosmic microwave background constraints, can provide the statistical accuracy required to answer questions about differences in the mass of individual neutrino species. Allowing for the possibility that masses are nondegenerate we combine Fisher matrix forecasts for a weak lensing survey like Euclid with those for the forthcoming Planck experiment. Under the assumption that neutrino mass splitting is described by a normal hierarchy we find that the combination Planck and Euclid will possibly reach enough sensitivity to put a constraint on the mass of a single species. Using a Bayesian evidence calculation we find that such future experiments could provide strong evidence for either a normal or an inverted neutrino hierarchy. Finally we show that if a particular neutrino hierarchy is assumed then this could bias cosmological parameter constraints, for example, the dark energy equation of state parameter, by > or approx. 1σ, and the sum of masses by 2.3σ. We finally discuss the impact of uncertainties on the theoretical modeling of nonlinearities. The results presented in this analysis are obtained under an approximation to the nonlinear power spectrum. This significant source of uncertainty needs to be addressed in future work.
Hierarchies in Coloured Petri Nets
DEFF Research Database (Denmark)
Huber, Peter; Jensen, Kurt; Shapiro, Robert M.
1991-01-01
constructs, and it illustrates them by means of two examples. The hierarchy constructs can be used for theoretical considerations, but their main use is to describe and analyse large real-world systems. All of the hierarchy constructs are supported by the editing and analysis facilities in the CPN Palette...
Completing the land resource hierarchy
The Land Resource Hierarchy of the NRCS is a hierarchal landscape classification consisting of resource areas which represent both conceptual and spatially discrete landscape units stratifying agency programs and practices. The Land Resource Hierarchy (LRH) scales from discrete points (soil pedon an...
Dominance Hierarchies in Young Children
Edelman, Murray S.; Omark, Donald R.
1973-01-01
This study uses the ethological approach of seeking species characteristics and phylogenetic continuities in an investigation of human behavior. Among primates a striking consistency is the presence of some form of dominance hierarchy in many species. The present study examines peer group dominance hierarchies as they are perceived by children in…
Maslow's Hierarchy of Needs Revisited.
Frame, Douglas
1996-01-01
Reviews Maslow's hierarchy of needs and characterization of the self-actualizing personality, suggesting that since few people meet his self-actualization criteria, an educational system designed to produce such personalities may fail, with teachers attending only to the hierarchy's lower stages (self-esteem and self-actualization) which dilutes…
On the supersymmetric BKP hierarchy
International Nuclear Information System (INIS)
Ramos, Eduardo; Stanciu, Sonia
1994-01-01
We prove that the supersymmetric BKP-hierarchy of Yu (SBKP 2 ) is hamiltonian with respect to a nonlinear extension of the N=1 super-Virasoro algebra (W SBKP ) by fields of spin k, where k>[3]/[2] and 2k≡0,3 (mod 4). Moreover, we show how to associate in a similar manner an N=1 W-superalgebra with every integrable hierarchy of the SKdV-type. We also show using dressing transformations how to extend, in a way which is compatible with the hamiltonian structure, the SBKP 2 hierarchy by odd flows, as well as the equivalence of this extended hierarchy to the SBKP-hierarchy of Manin-Radul. ((orig.))
An extended Harry Dym hierarchy
International Nuclear Information System (INIS)
Ma Wenxiu
2010-01-01
An extended Harry Dym hierarchy is constructed by using eigenfunctions and adjoint eigenfunctions of the spectral problems of the Harry Dym hierarchy associated with the pseudo-differential operator L = u∂ + u 0 + u 1 ∂ -1 + .... The corresponding Lax presentation possesses a self-consistent source involving squared eigenfunctions. The resulting extended Harry Dym hierarchy is reduced to the Harry Dym hierarchy with self-consistent sources under the n-reduction, L n = (L n ) ≥2 , and the k-constrained Harry Dym hierarchy under the k-constraint, L k = (L k ) ≥2 + Σ N i=1 q i ∂ -1 r i ∂ 2 . A few particular examples are computed, together with their Lax pairs.
Yu, Meng; Stevens, Vicky; Berry, Jody D; Crameri, Gary; McEachern, Jennifer; Tu, Changchun; Shi, Zhengli; Liang, Guodong; Weingartl, Hana; Cardosa, Jane; Eaton, Bryan T; Wang, Lin-Fa
2008-02-29
Knowledge of immunodominant regions in major viral antigens is important for rational design of effective vaccines and diagnostic tests. Although there have been many reports of such work done for SARS-CoV, these were mainly focused on the immune responses of humans and mice. In this study, we aim to search for and compare immunodominant regions of the spike (S) and nucleocapsid (N) proteins which are recognized by sera from different animal species, including mouse, rat, rabbit, civet, pig and horse. Twelve overlapping recombinant protein fragments were produced in Escherichia coli, six each for the S and N proteins, which covered the entire coding region of the two proteins. Using a membrane-strip based Western blot approach, the reactivity of each antigen fragment against a panel of animal sera was determined. Immunodominant regions containing linear epitopes, which reacted with sera from all the species tested, were identified for both proteins. The S3 fragment (aa 402-622) and the N4 fragment (aa 220-336) were the most immunodominant among the six S and N fragments, respectively. Antibodies raised against the S3 fragment were able to block the binding of a panel of S-specific monoclonal antibodies (mAb) to SARS-CoV in ELISA, further demonstrating the immunodominance of this region. Based on these findings, one-step competition ELISAs were established which were able to detect SARS-CoV antibodies from human and at least seven different animal species. Considering that a large number of animal species are known to be susceptible to SARS-CoV, these assays will be a useful tool to trace the origin and transmission of SARS-CoV and to minimise the risk of animal-to-human transmission.
DEFF Research Database (Denmark)
Steentoft, Catharina; Schjoldager, Katrine T; Cló, Emiliano
2010-01-01
antibody 237, developed to a spontaneous murine fibrosarcoma, was shown to be directed to murine podoplanin (OTS8) with truncated Tn O-glycans. Our understanding of such cancer-specific auto-antibodies to truncated glycoforms of glycoproteins is limited. Here we have investigated immunogenicity...... of a chemoenzymatically produced Tn-glycopeptide derived from the putative murine podoplanin O-glycopeptide epitope. We found that the Tn O-glycopeptide was highly immunogenic in mice and produced a Tn-glycoform specific response with no reactivity against unglycosylated peptides or the O-glycopeptide with extended O......-glycan (STn and T glycoforms). The immunodominant epitope was strictly dependent on the peptide sequence, required Tn at a specific single Thr residue (Thr(77)), and antibodies to the epitope were not found in naive mice. We further tested a Tn O-glycopeptide library derived from human podoplanin...
Dynamical hierarchies - A summary
Energy Technology Data Exchange (ETDEWEB)
Rasmussen, S.; Barrett, C.L. [Los Alamos National Lab., NM (United States)]|[Santa Fe Institute, NM (United States); Olesen, M.W. [Los Alamos National Lab., NM (United States)] [and others
1996-04-01
This paper summarizes some of the problems associated with the generation of higher order emergent structures in formal dynamical systems. In biological systems, higher order hyperstructures occur both in an intuitive and a formal sense: monomers, polymers, membranes, organelles, cells, tissues, organs, etc. constitute an observable hierarchy, apparently generated by the underlying biomolecular process. However, in models and simulations of these systems, it has turned out to be quite difficult to produce higher order emergent structures from first principles. The first problem is to agree on what a higher order structure is. An emergent structure can be defined through an introduction of an observational function. If a property can be observed in the dynamics, but not at the level of the fundamental first order interacting structures, we define it to be emergent. It is well known that second order structures occur relatively easy in simulation, so the problem is how to proceed to third and higher order without external interference. A third order structure is defined through the interaction of second order structures forming a new observable not found at the lower levels.
Energy Technology Data Exchange (ETDEWEB)
Haba, Naoyuki; Murayama, Hitoshi
2000-09-14
We advocate a new approach to study models of fermion massesand mixings, namely anarchy proposed in hep-ph/9911341. In this approach,we scan the O(1) coefficients randomly. We argue that this is the correctapproach when the fundamental theory is sufficiently complicated.Assuming there is no physical distinction among three generations ofneutrinos, the probability distributions in MNS mixing angles can bepredicted independent of the choice of the measure. This is because themixing angles are distributed according to the Haar measure of the Liegroups whose elements diagonalize the mass matrices. The near-maximalmixings, as observed in the atmospheric neutrino data and as required inthe LMA solution to the solar neutrino problem, are highly probable. Asmall hierarchy between the Delta m2 for the atmospheric and the solarneutrinos is obtained very easily; the complex seesaw case gives ahierarchy of a factor of 20 as the most probable one, even though thisconclusion is more measure-dependent. U_e3 has to be just below thecurrent limit from the CHOOZ experiment. The CP-violating parameter sindelta is preferred to be maximal. We present a simple SU(5)-likeextension of anarchy to the charged-lepton and quark sectors which workswell phenomenologically.
Pan, Mingjie; Wang, Xingsheng; Liao, Jianmin; Yin, Dengke; Li, Suqin; Pan, Ying; Wang, Yao; Xie, Guangyan; Zhang, Shumin; Li, Yuexi
2012-01-01
Twenty B candidate epitopes of glycoproteins B (gB2), C (gC2), E (gE2), G (gG2), and I (gI2) of herpes simplex virus type 2 (HSV-2) were predicted using DNAstar, Biosun, and Antheprot methods combined with the polynomial method. Subsequently, the biological functions of the peptides were tested via experiments in vitro. Among the 20 epitope peptides, 17 could react with the antisera to the corresponding parent proteins in the EIA tests. In particular, five peptides, namely, gB2(466-473) (EQDRKPRN), gC2(216-223) (GRTDRPSA), gE2(483-491) (DPPERPDSP), gG2(572-579) (EPPDDDDS), and gI2(286-295) (CRRRYRRPRG) had strong reaction with the antisera. All conjugates of the five peptides with the carrier protein BSA could stimulate mice into producing antibodies. The antisera to these peptides reacted strongly with the corresponding parent glycoproteins during the Western Blot tests, and the peptides reacted strongly with the antibodies against the parent glycoproteins during the EIA tests. The antisera against the five peptides could neutralize HSV-2 infection in vitro, which has not been reported until now. These results suggest that the immunodominant epitopes screened using software algorithms may be used for virus diagnosis and vaccine design against HSV-2.
Directory of Open Access Journals (Sweden)
Mingjie Pan
2012-01-01
Full Text Available Twenty B candidate epitopes of glycoproteins B (gB2, C (gC2, E (gE2, G (gG2, and I (gI2 of herpes simplex virus type 2 (HSV-2 were predicted using DNAstar, Biosun, and Antheprot methods combined with the polynomial method. Subsequently, the biological functions of the peptides were tested via experiments in vitro. Among the 20 epitope peptides, 17 could react with the antisera to the corresponding parent proteins in the EIA tests. In particular, five peptides, namely, gB2466–473 (EQDRKPRN, gC2216–223 (GRTDRPSA, gE2483–491 (DPPERPDSP, gG2572–579 (EPPDDDDS, and gI2286-295 (CRRRYRRPRG had strong reaction with the antisera. All conjugates of the five peptides with the carrier protein BSA could stimulate mice into producing antibodies. The antisera to these peptides reacted strongly with the corresponding parent glycoproteins during the Western Blot tests, and the peptides reacted strongly with the antibodies against the parent glycoproteins during the EIA tests. The antisera against the five peptides could neutralize HSV-2 infection in vitro, which has not been reported until now. These results suggest that the immunodominant epitopes screened using software algorithms may be used for virus diagnosis and vaccine design against HSV-2.
Gauge-symmetry hierarchies revisited
International Nuclear Information System (INIS)
Gildener, E.
1979-01-01
It was shown by the author in a previous paper that in each order of perturbation theory there is an upper bound on the range of validity of a gauge hierarchy. Thus constructing a large hierarchy requires a fine-tuning of the scalar-field parameters. It was stated that the possibility of an inherent bound on the hierarchy exists, but the question of the actual existence of such a bound was left completely open. Since then several authors have addressed this problem. Some of what the author asserted was misunderstood, and incorrect conclusions have been drawn from recent computations. It has been claimed that the existence of large hierarchies has been demonstrated. It is the purpose of this paper to refute this claim, to help clarify the situation, and to explain why the status of this problem has in fact not really changed in recent years (author)
Principles of synchronous digital hierarchy
Jain, Rajesh Kumar
2012-01-01
The book presents the current standards of digital multiplexing, called synchronous digital hierarchy, including analog multiplexing technologies. It is aimed at telecommunication professionals who want to develop an understanding of digital multiplexing and synchronous digital hierarchy in particular and the functioning of practical telecommunication systems in general. The text includes all relevant fundamentals and provides a handy reference for problem solving or defining operations and maintenance strategies. The author covers digital conversion and TDM principles, line coding and digital
Information slows down hierarchy growth.
Czaplicka, Agnieszka; Suchecki, Krzysztof; Miñano, Borja; Trias, Miquel; Hołyst, Janusz A
2014-06-01
We consider models of growing multilevel systems wherein the growth process is driven by rules of tournament selection. A system can be conceived as an evolving tree with a new node being attached to a contestant node at the best hierarchy level (a level nearest to the tree root). The proposed evolution reflects limited information on system properties available to new nodes. It can also be expressed in terms of population dynamics. Two models are considered: a constant tournament (CT) model wherein the number of tournament participants is constant throughout system evolution, and a proportional tournament (PT) model where this number increases proportionally to the growing size of the system itself. The results of analytical calculations based on a rate equation fit well to numerical simulations for both models. In the CT model all hierarchy levels emerge, but the birth time of a consecutive hierarchy level increases exponentially or faster for each new level. The number of nodes at the first hierarchy level grows logarithmically in time, while the size of the last, "worst" hierarchy level oscillates quasi-log-periodically. In the PT model, the occupations of the first two hierarchy levels increase linearly, but worse hierarchy levels either do not emerge at all or appear only by chance in the early stage of system evolution to further stop growing at all. The results allow us to conclude that information available to each new node in tournament dynamics restrains the emergence of new hierarchy levels and that it is the absolute amount of information, not relative, which governs such behavior.
Quantify entanglement by concurrence hierarchy
Fan, Heng; Matsumoto, Keiji; Imai, Hiroshi
2002-01-01
We define the concurrence hierarchy as d-1 independent invariants under local unitary transformations in d-level quantum system. The first one is the original concurrence defined by Wootters et al in 2-level quantum system and generalized to d-level pure quantum states case. We propose to use this concurrence hierarchy as measurement of entanglement. This measurement does not increase under local quantum operations and classical communication.
Information slows down hierarchy growth
Czaplicka, Agnieszka; Suchecki, Krzysztof; Miñano, Borja; Trias, Miquel; Hołyst, Janusz A.
2014-06-01
We consider models of growing multilevel systems wherein the growth process is driven by rules of tournament selection. A system can be conceived as an evolving tree with a new node being attached to a contestant node at the best hierarchy level (a level nearest to the tree root). The proposed evolution reflects limited information on system properties available to new nodes. It can also be expressed in terms of population dynamics. Two models are considered: a constant tournament (CT) model wherein the number of tournament participants is constant throughout system evolution, and a proportional tournament (PT) model where this number increases proportionally to the growing size of the system itself. The results of analytical calculations based on a rate equation fit well to numerical simulations for both models. In the CT model all hierarchy levels emerge, but the birth time of a consecutive hierarchy level increases exponentially or faster for each new level. The number of nodes at the first hierarchy level grows logarithmically in time, while the size of the last, "worst" hierarchy level oscillates quasi-log-periodically. In the PT model, the occupations of the first two hierarchy levels increase linearly, but worse hierarchy levels either do not emerge at all or appear only by chance in the early stage of system evolution to further stop growing at all. The results allow us to conclude that information available to each new node in tournament dynamics restrains the emergence of new hierarchy levels and that it is the absolute amount of information, not relative, which governs such behavior.
Recommended HSE-7 documents hierarchy
International Nuclear Information System (INIS)
Klein, R.B.; Jennrich, E.A.; Lund, D.M.; Danna, J.G.; Davis, K.D.; Rutz, A.C.
1990-01-01
This report recommends a hierarchy of waste management documents at Los Alamos National Laboratory (LANL or ''Laboratory''). The hierarchy addresses documents that are required to plan, implement, and document waste management programs at Los Alamos. These documents will enable the waste management group and the six sections contained within that group to satisfy requirements that are imposed upon them by the US Department of Energy (DOE), DOE Albuquerque Operations, US Environmental Protection Agency, various State of New Mexico agencies, and Laboratory management
Visualising large hierarchies with Flextree
Song, Hongzhi; Curran, Edwin P.; Sterritt, Roy
2003-05-01
One of the main tasks in Information Visualisation research is creating visual tools to facilitate human understanding of large and complex information spaces. Hierarchies, being a good mechanism in organising such information, are ubiquitous. Although much research effort has been spent on finding useful representations for hierarchies, visualising large hierarchies is still a difficult topic. One of the difficulties is how to show both tructure and node content information in one view. Another is how to achieve multiple foci in a focus+context visualisation. This paper describes a novel hierarchy visualisation technique called FlexTree to address these problems. It contains some important features that have not been exploited so far. In this visualisation, a profile or contour unique to the hierarchy being visualised can be gained in a histogram-like layout. A normalised view of a common attribute of all nodes can be acquired, and selection of this attribute is controllable by the user. Multiple foci are consistently accessible within a global context through interaction. Furthermore it can handle a large hierarchy that contains several thousand nodes in a PC environment. In addition results from an informal evaluation are also presented.
A Machian solution of the hierarchy problem
International Nuclear Information System (INIS)
Gogberashvili, M.
2008-01-01
The new interpretation of Mach's principle of mass of a particle being a measure of the interactions of this particle with all other gravitating particles inside its causal spheres is introduced. It is shown that within some alternative model of gravitation that incorporates this principle, the Machian influence of the universe can reduce Planck's scale to the electro-weak scale and the large number that is needed to explain the hierarchy between the scales is the amount of gravitating particles inside the universe horizon. Our model can lead to new observable effects at cosmological distances and close to the sources of a strong gravitational field. (orig.)
Special polynomials associated with some hierarchies
International Nuclear Information System (INIS)
Kudryashov, Nikolai A.
2008-01-01
Special polynomials associated with rational solutions of a hierarchy of equations of Painleve type are introduced. The hierarchy arises by similarity reduction from the Fordy-Gibbons hierarchy of partial differential equations. Some relations for these special polynomials are given. Differential-difference hierarchies for finding special polynomials are presented. These formulae allow us to obtain special polynomials associated with the hierarchy studied. It is shown that rational solutions of members of the Schwarz-Sawada-Kotera, the Schwarz-Kaup-Kupershmidt, the Fordy-Gibbons, the Sawada-Kotera and the Kaup-Kupershmidt hierarchies can be expressed through special polynomials of the hierarchy studied
Grassmannian approach to super-KP hierarchies
International Nuclear Information System (INIS)
Takama, Michiaki.
1995-06-01
We present a theory of 'maximal' super-KP (SKP) hierarchy whose flows are maximally extended to include all those of known SKP hierarchies, including, for example, the MRSKP hierarchy of Manin and Radul and the Jacobian SKP (JSKP) introduced by Mulase and Rabin. It is shown that SKP hierarchies has a natural field theoretic description in terms of the B-C system, in analogous way as the ordinary KP hierarchy. For this SKP hierarchy, we construct the vertex operators by using Kac-van de Leur superbosonization. The vertex operators act on the τ-function and then produce the wave function and the dual wave function of the hierarchy. Thereby we achieve the description of the 'maximal' SKP hierarchy in terms of the τ-function, which seemed to be lacking till now. Mutual relations among the SKP hierarchies are clarified. The MRSKP and the JSKP hierarchies are obtained as special cases when the time variables are appropriately restricted. (author)
Recursion Operators for Dispersionless KP Hierarchy
International Nuclear Information System (INIS)
Cheng Qiusheng; He Jingsong
2012-01-01
Based on the corresponding theorem between dispersionless KP (dKP) hierarchy and ħ-dependent KP (ħKP) hierarchy, a general formal representation of the recursion operators for dKP hierarchy under n-reduction is given in a systematical way from the corresponding ħKP hierarchy. To illustrate this method, the recursion operators for dKP hierarchy under 2-reduction and 3-reduction are calculated in detail.
Poisson hierarchy of discrete strings
International Nuclear Information System (INIS)
Ioannidou, Theodora; Niemi, Antti J.
2016-01-01
The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.
The extended bigraded Toda hierarchy
International Nuclear Information System (INIS)
Carlet, Guido
2006-01-01
We generalize the Toda lattice hierarchy by considering N + M dependent variables. We construct roots and logarithms of the Lax operator which are uniquely defined operators with coefficients that are ε-series of differential polynomials in the dependent variables, and we use them to provide a Lax pair definition of the extended bigraded Toda hierarchy, generalizing [4]. Using R-matrix theory we give the bi-Hamiltonian formulation of this hierarchy and we prove the existence of a tau function for its solutions. Finally we study the dispersionless limit and its connection with a class of Frobenius manifolds on the orbit space of the extended affine Weyl groups W-tilde (N) (A N+M-1 ) of the A series, defined by Dubrovin and Zhang (1998 Compos. Math. 111 167)
Poisson hierarchy of discrete strings
Energy Technology Data Exchange (ETDEWEB)
Ioannidou, Theodora, E-mail: ti3@auth.gr [Faculty of Civil Engineering, School of Engineering, Aristotle University of Thessaloniki, 54249, Thessaloniki (Greece); Niemi, Antti J., E-mail: Antti.Niemi@physics.uu.se [Department of Physics and Astronomy, Uppsala University, P.O. Box 803, S-75108, Uppsala (Sweden); Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, Fédération Denis Poisson, Université de Tours, Parc de Grandmont, F37200, Tours (France); Department of Physics, Beijing Institute of Technology, Haidian District, Beijing 100081 (China)
2016-01-28
The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.
The Development of Hierarchy of Effects Model in Advertising
Bambang Sukma Wijaya
2012-01-01
This paper aims to review the hierarchy of effects models in adverti-sing, especially the well-known model, AIDA (Attention, Interest, De-sire, and Action). Since its introduction by Lewis (1900) and generally attributed in the marketing and advertising literature by Strong (1925), the concept of AIDA’s hierarchy of effects model has been used by many researchers, both academicians and practitioners. The model is used to measure the effect of an advertisement. However, the deve-lopment of inf...
New supersymmetrizations of the generalized KDV hierarchies
International Nuclear Information System (INIS)
Figueroa-O'Farrill, J.M.; Stanciu, S.
1993-03-01
Recently we investigated a new supersymmetrization procedure for the KdV hierarchy inspired in some recent work on supersymmetric matrix models. We extend this procedure here for the generalized KdV hierarchies. The resulting supersymmetric hierarchies are generically nonlocal, expect for the case of Boussinesque which we treat in detail. The resulting supersymmetric hierarchy is integrable and bihamiltonian and contains the Boussinesque hierarchy as a subhierarchy. In a particular realization, we extend it by defining supersymmetric odd flows. We end with some comments on a slight modification of this supersymmetrization which yields local equations for any generalized KdV hierarchy. (orig.)
The Hierarchy of Segment Reports
Directory of Open Access Journals (Sweden)
Danilo Dorović
2015-05-01
Full Text Available The article presents an attempt to find the connection between reports created for managers responsible for different business segments. With this purpose, the hierarchy of the business reporting segments is proposed. This can lead to better understanding of the expenses under common responsibility of more than one manager since these expenses should be in more than one report. The structure of cost defined per business segment hierarchy with the aim of new, unusual but relevant cost structure for management can be established. Both could potentially bring new information benefits for management in the context of profit reporting.
Directory of Open Access Journals (Sweden)
Stefanie Ameres
Full Text Available Control of human cytomegalovirus (HCMV depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins. Here we show that HCMV immunoevasins differentially impair T cell recognition of epitopes from the same viral antigen, immediate-early 1 (IE-1, that are presented by different MHC class I allotypes. In the presence of immunoevasins, HLA-A- and HLA-B-restricted T cell clones were ineffective, but HLA-C*0702-restricted T cell clones recognized and killed infected cells. Resistance of HLA-C*0702 to viral immunoevasins US2 and US11 was mediated by the alpha3 domain and C-terminal region of the HLA heavy chain. In healthy donors, HLA-C*0702-restricted T cells dominated the T cell response to IE-1. The same HLA-C allotype specifically protected infected cells from attack by NK cells that expressed a corresponding HLA-C-specific KIR. Thus, allotype-specific viral immunoevasion allows HCMV to escape control by NK cells and HLA-A- and HLA-B-restricted T cells, while the virus becomes selectively vulnerable to an immunodominant population of HLA-C-restricted T cells. Our work identifies a T cell population that may be of particular efficiency in HCMV-specific immunotherapy.
Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane Protein
Directory of Open Access Journals (Sweden)
Hui Dong
2016-12-01
Full Text Available The coronavirus membrane (M protein acts as a dominant immunogen and is a major player in virus assembly. In this study, we prepared two monoclonal antibodies (mAbs; 1C3 and 4C7 directed against the transmissible gastroenteritis virus (TGEV M protein. The 1C3 and 4C7 mAbs both reacted with the native TGEV M protein in western blotting and immunofluorescence (IFA assays. Two linear epitopes, 243YSTEART249 (1C3 and 243YSTEARTDNLSEQEKLLHMV262 (4C7, were identified in the endodomain of the TGEV M protein. The 1C3 mAb can be used for the detection of the TGEV M protein in different assays. An IFA method for the detection of TGEV M protein was optimized using mAb 1C3. Furthermore, the ability of the epitope identified in this study to stimulate antibody production was also evaluated. An immunodominant epitope in the TGEV membrane protein endodomain was identified. The results of this study have implications for further research on TGEV replication.
Hierarchy curriculum for practical skills training in optics and photonics
Zheng, XiaoDong; Wang, XiaoPing; Liu, Xu; Liu, XiangDong; Lin, YuanFang
2017-08-01
The employers in optical engineering fields hope to recruit students who are capable of applying optical principles to solve engineering problems and have strong laboratory skills. In Zhejiang University, a hierarchy curriculum for practical skill training has been constructed to satisfy this demand. This curriculum includes "Introductive practicum" for freshmen, "Opto-mechanical systems design", "Engineering training", "Electronic system design", "Student research training program (SRTP)", "National University Students' Optical-Science-Technology Competition game", and "Offcampus externship". Without cutting optical theory credit hours, this hierarchy curriculum provides a step-by-step solution to enhance students' practical skills. By following such a hierarchy curriculum, students can smoothly advance from a novice to a qualified professional expert in optics. They will be able to utilize optical engineering tools to design, build, analyze, improve, and test systems, and will be able to work effectively in teams to solve problems in engineering and design.
International Nuclear Information System (INIS)
Gao, Feng; Bao, Jinku
2013-01-01
A primitive monoclinic crystal of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an SIVmac239 Env peptide was obtained and belonged to space group P2, with unit-cell parameters a = 68.3, b = 45.0, c = 81.5 Å, β = 96.5°. The crystal diffracted to 2.55 Å resolution. Long-term nonprogression during simian immunodeficiency virus (SIV) infection has been strongly associated with the major histocompatibility complex (MHC) class I allele Mamu-B*17. Here, a complex of rhesus macaque Mamu-B*17 with rhesus macaque β 2 -microglobulin (β 2 m) and an immunodominant peptide (SIVmac239 Env241–251; LRCNDTNYSGF; Env LF11) derived from the SIV Env protein was crystallized by the hanging-drop method using PEG 3350 as a precipitating agent. The crystals belonged to the primitive monoclinic space group P2, with unit-cell parameters a = 68.3, b = 45.0, c = 81.5 Å, β = 96.5°. Assuming the presence of one molecule in the asymmetric unit, the Matthews coefficient and solvent content were calculated to be 2.96 Å 3 Da −1 and 58.5%, respectively
Objective Bayesian analysis of neutrino masses and hierarchy
Heavens, Alan F.; Sellentin, Elena
2018-04-01
Given the precision of current neutrino data, priors still impact noticeably the constraints on neutrino masses and their hierarchy. To avoid our understanding of neutrinos being driven by prior assumptions, we construct a prior that is mathematically minimally informative. Using the constructed uninformative prior, we find that the normal hierarchy is favoured but with inconclusive posterior odds of 5.1:1. Better data is hence needed before the neutrino masses and their hierarchy can be well constrained. We find that the next decade of cosmological data should provide conclusive evidence if the normal hierarchy with negligible minimum mass is correct, and if the uncertainty in the sum of neutrino masses drops below 0.025 eV. On the other hand, if neutrinos obey the inverted hierarchy, achieving strong evidence will be difficult with the same uncertainties. Our uninformative prior was constructed from principles of the Objective Bayesian approach. The prior is called a reference prior and is minimally informative in the specific sense that the information gain after collection of data is maximised. The prior is computed for the combination of neutrino oscillation data and cosmological data and still applies if the data improve.
The Development of Hierarchy of Effects Model in Advertising
Directory of Open Access Journals (Sweden)
Bambang Sukma Wijaya
2012-04-01
Full Text Available This paper aims to review the hierarchy of effects models in adverti-sing, especially the well-known model, AIDA (Attention, Interest, De-sire, and Action. Since its introduction by Lewis (1900 and generally attributed in the marketing and advertising literature by Strong (1925, the concept of AIDA’s hierarchy of effects model has been used by many researchers, both academicians and practitioners. The model is used to measure the effect of an advertisement. However, the deve-lopment of information technology has radically changed the way of how people communicate and socialize; as well as a paradigm shift from product-oriented marketing to consumer-oriented marketing or people-oriented marketing. Therefore, the variables in the hierarchy of effects model needs to be updated in respond to the latest develop-ments in the notice of public power as consumer audience. Based on deep literature review and reflective method, this paper introduces a new developed concept of hierarchy of effects model that was adop-ted from AIDA’s hierarchy of effects model, namely: AISDALSLove (At-tention, Interest, Search, Desire, Action, Like/dislike, Share, and Love/hate.
The Development of Hierarchy of Effects Model in Advertising
Directory of Open Access Journals (Sweden)
Bambang Sukma Wijaya
2012-04-01
Full Text Available This paper aims to review the hierarchy of effects models in advertising, especially the well-known model, AIDA (Attention, Interest, Desire, and Action. Since its introduction by Lewis (1900 and generally attributed in the marketing and advertising literature by Strong (1925, the concept of AIDA’s hierarchy of effects model has been used by many researchers, both academicians and practitioners. The model is used to measure the effect of an advertisement. However, the development of information technology has radically changed the way of how people communicate and socialize; as well as a paradigm shift from product-oriented marketing to consumer-oriented marketing or people-oriented marketing. Therefore, the variables in the hierarchy of effects model needs to be updated in respond to the latest developments in the notice of public power as consumer audience. Based on deep literature review and reflective method, this paper introduces a new developed concept of hierarchy of effects model that was adopted from AIDA’s hierarchy of effects model, namely: AISDALSLove (At-tention, Interest, Search, Desire, Action, Like/dislike, Share, and Love/hate.
The Evolutionary Origins of Hierarchy.
Mengistu, Henok; Huizinga, Joost; Mouret, Jean-Baptiste; Clune, Jeff
2016-06-01
Hierarchical organization-the recursive composition of sub-modules-is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments). Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force-the cost of connections-promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.
The Evolutionary Origins of Hierarchy
Huizinga, Joost; Clune, Jeff
2016-01-01
Hierarchical organization—the recursive composition of sub-modules—is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments). Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force–the cost of connections–promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics. PMID:27280881
The Evolutionary Origins of Hierarchy.
Directory of Open Access Journals (Sweden)
Henok Mengistu
2016-06-01
Full Text Available Hierarchical organization-the recursive composition of sub-modules-is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments. Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force-the cost of connections-promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.
Hierarchy in directed random networks.
Mones, Enys
2013-02-01
In recent years, the theory and application of complex networks have been quickly developing in a markable way due to the increasing amount of data from real systems and the fruitful application of powerful methods used in statistical physics. Many important characteristics of social or biological systems can be described by the study of their underlying structure of interactions. Hierarchy is one of these features that can be formulated in the language of networks. In this paper we present some (qualitative) analytic results on the hierarchical properties of random network models with zero correlations and also investigate, mainly numerically, the effects of different types of correlations. The behavior of the hierarchy is different in the absence and the presence of giant components. We show that the hierarchical structure can be drastically different if there are one-point correlations in the network. We also show numerical results suggesting that the hierarchy does not change monotonically with the correlations and there is an optimal level of nonzero correlations maximizing the level of hierarchy.
Void hierarchy and cosmic structure
International Nuclear Information System (INIS)
Weygaert, Rien van de; Ravi Sheth
2004-01-01
Within the context of hierarchical scenarios of gravitational structure formation we describe how an evolving hierarchy of voids evolves on the basis of two processes, the void-in-void process and the void-in-cloud process. The related analytical formulation in terms of a two-barrier excursion problem leads to a self-similarly evolving peaked void size distribution
Maslow's Hierarchy and Student Retention.
Brookman, David M.
1989-01-01
Abraham Maslow's hierarchy of needs offers perspective on student motivation and a rationale for college retention programing. Student affairs and faculty interventions addressing student safety needs and engaging students' sense of purpose reinforce persistence. A mentor program is a possible cooperative effort between student personnel and…
Friesen, Justin P; Kay, Aaron C; Eibach, Richard P; Galinsky, Adam D
2014-04-01
Hierarchies are a ubiquitous form of human social organization. We hypothesized that 1 reason for the prevalence of hierarchies is that they offer structure and therefore satisfy the core motivational needs for order and control relative to less structured forms of social organization. This hypothesis is rooted in compensatory control theory, which posits that (a) individuals have a basic need to perceive the world as orderly and structured, and (b) personal and external sources of control are capable of satisfying this need because both serve the comforting belief that the world operates in an orderly fashion. Our first 2 studies confirmed that hierarchies were perceived as more structured and orderly relative to egalitarian arrangements (Study 1) and that working in a hierarchical workplace promotes a feeling of self-efficacy (Study 2). We threatened participants' sense of personal control and measured perceptions of and preferences for hierarchy in 5 subsequent experiments. Participants who lacked control perceived more hierarchy occurring in ambiguous social situations (Study 3) and preferred hierarchy more strongly in workplace contexts (Studies 4-5). We also provide evidence that hierarchies are indeed appealing because of their structure: Preference for hierarchy was higher among individuals high in Personal Need for Structure and a control threat increased preference for hierarchy even among participants low in Personal Need for Structure (Study 5). Framing a hierarchy as unstructured reversed the effect of control threat on hierarchy (Study 6). Finally, hierarchy-enhancing jobs were more appealing after control threat, even when they were low in power and status (Study 7). (PsycINFO Database Record (c) 2014 APA, all rights reserved).
A note on the dispersionless BKP hierarchy
International Nuclear Information System (INIS)
Chen, Y.-T.; Tu, M.-H.
2006-01-01
We study the integrable hierarchy underlying topological Landau-Ginzburg models of D-type proposed by Takasaki. Since this integrable hierarchy contains the dBKP hierarchy as a sub-hierarchy, we refer it to the extended dBKP (EdBKP) hierarchy. We give a dressing formulation to the EdBKP hierarchy and investigate additional symmetries associated with the solution space of the hierarchy. We obtain hodograph solutions of its finite-dimensional reductions via Riemann-Hilbert problem (twistor construction) and derive Baecklund transformations of the (2 + 1)-dimensional dBKP equation from additional flows. Finally, the modified partner of the dBKP hierarchy is also established through a Miura transformation
The problem of symmetry breaking hierarchy
International Nuclear Information System (INIS)
Natale, A.A.
1983-01-01
The problem of symmetry breaking hierarchy in grand unified theories is discussed, proving the impossibility to get a big hierarchy of interactions, in a natural way within the framework of perturbation theory. (L.C.) [pt
Strong Electroweak Symmetry Breaking
Grinstein, Benjamin
2011-01-01
Models of spontaneous breaking of electroweak symmetry by a strong interaction do not have fine tuning/hierarchy problem. They are conceptually elegant and use the only mechanism of spontaneous breaking of a gauge symmetry that is known to occur in nature. The simplest model, minimal technicolor with extended technicolor interactions, is appealing because one can calculate by scaling up from QCD. But it is ruled out on many counts: inappropriately low quark and lepton masses (or excessive FCNC), bad electroweak data fits, light scalar and vector states, etc. However, nature may not choose the minimal model and then we are stuck: except possibly through lattice simulations, we are unable to compute and test the models. In the LHC era it therefore makes sense to abandon specific models (of strong EW breaking) and concentrate on generic features that may indicate discovery. The Technicolor Straw Man is not a model but a parametrized search strategy inspired by a remarkable generic feature of walking technicolor,...
Exact Solutions for Two Equation Hierarchies
International Nuclear Information System (INIS)
Song-Lin, Zhao; Da-Jun, Zhang; Jie, Ji
2010-01-01
Bilinear forms and double-Wronskian solutions are given for two hierarchies, the (2+1)-dimensional breaking Ablowitz–Kaup–Newell–Segur (AKNS) hierarchy and the negative order AKNS hierarchy. According to some choices of the coefficient matrix in the Wronskian condition equation set, we obtain some kinds of solutions for these two hierarchies, such as solitons, Jordan block solutions, rational solutions, complexitons and mixed solutions. (general)
Additional symmetries of supersymmetric KP hierarchies
International Nuclear Information System (INIS)
Stanciu, S.
1994-01-01
We investigate the additional symmetries of several supersymmetric KP hierarchies: the SKP hierarchy of Manin and Radul, the SKP 2 hierarchy, and the Jacobian SKP hierarchy. In all three cases we find that the algebra of symmetries is isomorphic to the algebra of superdifferential operators, or equivalently SW 1+∞ . These results seem to suggest that despite their realization depending on the dynamics, the additional symmetries are kinematical in nature. (orig.)
International Nuclear Information System (INIS)
Depireux, D.A.
1992-01-01
In this paper, given the two boson representation of the conformal algebra W ∞ , the second Hamiltonian structure of the KP hierarchy, the author constructs a bi-Hamiltonian hierarchy for the two associated currents. The KP hierarchy appears as a composite of this new and simpler system. The bi-Hamiltonian structure of the new hierarchy gives naturally all the Hamiltonian structures of the KP system
A Hierarchy Model of Income Distribution
Fix, Blair
2018-01-01
Based on worldly experience, most people would agree that firms are hierarchically organized, and that pay tends to increase as one moves up the hierarchy. But how this hierarchical structure affects income distribution has not been widely studied. To remedy this situation, this paper presents a new model of income distribution that explores the effects of social hierarchy. This ‘hierarchy model’ takes the limited available evidence on the structure of firm hierarchies and generalizes it to c...
Natural gauge hierarchy in SO(10)
International Nuclear Information System (INIS)
Babu, K.S.; Barr, S.M.
1994-01-01
It is shown that a natural gauge hierarchy and doublet-triplet splitting can be achieved in SO(10) using the Dimopoulos-Wilczek mechanism. Artificial cancellations (fine-tuning) and arbitrary forms of the superpotential are avoided, the superpotential being the most general compatible with a symmetry. It is shown by example that the Dimopoulos-Wilczek mechanism can be protected against the effects of higher-dimension operators possibly induced by Planck-scale physics. Natural implementation of the mechanisms leads to an automatic Peccei-Quinn symmetry. The same local symmetries that would protect the gauge hierarchy against Planck-scale effects tend to protect the axion also. How realistic quark and lepton masses might arise in this framework is discussed. It is shown how the theory may remain perturbative up to the Planck scale. It is also argued that ''weak suppression'' of proton decay can be implemented more economically than can ''strong suppression,'' offering some grounds to hope [in the context of SO(10)] that proton decay could be seen at SuperKamiokande
Generalized Miura transformations, two-bosons KP hierarchies and their reduction to KdV hierarchies
International Nuclear Information System (INIS)
Aratyn, H.; Ferreira, L.A.; Gomes, J.F.; Medeiros, R.T.; Zimerman, A.H.
1993-02-01
Bracket preserving gauge equivalence is established between several two-boson generated KP type of hierarchies. These KP hierarchies reduce under symplectic reduction (via Dirac constraints) to KdV and Schwarzian KdV hierarchies. Under this reduction the gauge equivalence is taking form of the conventional Miura maps between the above KdV type of hierarchies. (author). 16 refs
Generalized Miura transformations, two-bosons KP hierarchies and their reduction to KdV hierarchies
Energy Technology Data Exchange (ETDEWEB)
Aratyn, H. [Illinois Univ., Chicago, IL (United States). Dept. of Physics; Ferreira, L.A.; Gomes, J.F.; Medeiros, R.T.; Zimerman, A.H.
1993-02-01
Bracket preserving gauge equivalence is established between several two-boson generated KP type of hierarchies. These KP hierarchies reduce under symplectic reduction (via Dirac constraints) to KdV and Schwarzian KdV hierarchies. Under this reduction the gauge equivalence is taking form of the conventional Miura maps between the above KdV type of hierarchies. (author). 16 refs.
Generalized W-algebras and integrable hierarchies
International Nuclear Information System (INIS)
Burroughs, N.; De Groot, M.; Hollowood, T.; Miramontes, L.
1992-01-01
We report on generalizations of the KdV-type integrable hierarchies of Drinfel'd and Sokolov. These hierarchies lead to the existence of new classical W-algebras, which arise as the second hamiltonian structure of the hierarchies. In particular, we present a construction of the W n (l) -algebras. (orig.)
BBGKY hierarchy and dynamics of correlations
International Nuclear Information System (INIS)
Polishchuk, D.O.
2010-01-01
We derive the BBGKY hierarchy for the Fermi and Bose many-particle systems, using the von Neumann hierarchy for the correlation operators. The solution of the Cauchy problem of the formulated hierarchy in the case of an n-body interaction potential is constructed in the space of sequences of trace-class operators.
Additional symmetries of supersymmetric KP hierarchies
International Nuclear Information System (INIS)
Stanciu, S.
1993-09-01
We investigate the additional symmetries of several supersymmetric KP hierarchies: The SKP hierarchy of Manin and Radul, the SKP 2 hierarchy, and the Jacobian SKP hierarchy. The main technical tool is the supersymmetric generalisation of a map originally due to Radul between the Lie algebra of superdifferential operators and the Lie algebra of vector fields on the space of supersymmetric Lax operators. In the case of the Manin-Radul SKP hierarchy we identify additional symmetries which form an algebra isomorphic to a subalgebra of superdifferential operators; whereas in the case of the Jacobian SKP, the (additional) symmetries are identified with the algebra itself. (orig.)
Hierarchy Measure for Complex Networks
Mones, Enys; Vicsek, Lilla; Vicsek, Tamás
2012-01-01
Nature, technology and society are full of complexity arising from the intricate web of the interactions among the units of the related systems (e.g., proteins, computers, people). Consequently, one of the most successful recent approaches to capturing the fundamental features of the structure and dynamics of complex systems has been the investigation of the networks associated with the above units (nodes) together with their relations (edges). Most complex systems have an inherently hierarchical organization and, correspondingly, the networks behind them also exhibit hierarchical features. Indeed, several papers have been devoted to describing this essential aspect of networks, however, without resulting in a widely accepted, converging concept concerning the quantitative characterization of the level of their hierarchy. Here we develop an approach and propose a quantity (measure) which is simple enough to be widely applicable, reveals a number of universal features of the organization of real-world networks and, as we demonstrate, is capable of capturing the essential features of the structure and the degree of hierarchy in a complex network. The measure we introduce is based on a generalization of the m-reach centrality, which we first extend to directed/partially directed graphs. Then, we define the global reaching centrality (GRC), which is the difference between the maximum and the average value of the generalized reach centralities over the network. We investigate the behavior of the GRC considering both a synthetic model with an adjustable level of hierarchy and real networks. Results for real networks show that our hierarchy measure is related to the controllability of the given system. We also propose a visualization procedure for large complex networks that can be used to obtain an overall qualitative picture about the nature of their hierarchical structure. PMID:22470477
Information, Authority, and Corporate Hierarchies
Choe, Chongwoo; In-Uck, Park
2010-01-01
In a typical corporate hierarchy, the manager is delegated the authority to make strategic decisions, and to contract with other employees. By studying a model with one principal and two agents where one agent can gather information that is valuable for the principal's project choice and the other agent provides effort to the chosen project, we study when the principal can benefit from such delegation relative to centralization. We show that beneficial delegation is possible when complete con...
Combinatorial solutions to integrable hierarchies
Kazarian, M. E.; Lando, S. K.
2015-06-01
This paper reviews modern approaches to the construction of formal solutions to integrable hierarchies of mathematical physics whose coefficients are answers to various enumerative problems. The relationship between these approaches and the combinatorics of symmetric groups and their representations is explained. Applications of the results to the construction of efficient computations in problems related to models of quantum field theories are described. Bibliography: 34 titles.
International Nuclear Information System (INIS)
Elwood, J.K.; Irges, N.; Ramond, P.
1997-05-01
The authors present a model for the observed hierarchies among the Yukawa couplings of the standard model in the context of an effective low energy theory with an anomalous U(1) symmetry. This symmetry, a generic feature of superstring compactification, is a remnant of the Green-Schwarz anomaly cancellation mechanism. The gauge group is that of the standard model, augmented by X, the anomalous U(1), and two family-dependent phase symmetries Y (1) and Y (2) . The correct hierarchies are reproduced only when sin 2 θ w = 3/8 at the cut-off. To cancel anomalies, right-handed neutrinos and other standard model singlets must be introduced. Independently of the charges of the right-handed neutrinos, this model produces the same neutrino mixing matrix and an inverted hierarchy of neutrino masses. The heaviest is the electron neutrino with a mass ∼ 1 meV, and mixing of the order of λ c 3 with each of the other two neutrinos
Energy Technology Data Exchange (ETDEWEB)
Su, Qiudong; Yi, Yao [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China); Guo, Minzhuo [Beijing Entry-Exit Inspection and Quarantine Beureau, Tianshuiyuan Lane 6, Chaoyang District, Beijing 100026 (China); Qiu, Feng; Jia, Zhiyuan; Lu, Xuexin; Meng, Qingling [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China); Bi, Shengli, E-mail: shengli_bi@163.com [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China)
2013-09-13
Highlights: •The conformational HBV neutralization antigen domain was successfully displayed on the surface of truncated HBc particles. •Appropriate dialysis procedures to support the renaturing environment for the protein refolding. •Efficient purification procedures to obtain high purity and icosahedral particles of mosaic HBV antigen. •Strong immune responses not only including neutralization antibody response but also Th1 cell response were induced in mice. -- Abstract: Hepatitis B capsid protein expressed in Escherichia coli can reassemble into icosahedral particles, which could strongly enhance the immunogenicity of foreign epitopes, especially those inserted into its major immunodominant region. Herein, we inserted the entire ‘α’ antigenic determinant amino acids (aa) 119–152 of HBsAg into the truncated HBc (aa 1–144), between Asp{sup 78} and Pro{sup 79}. Prokaryotic expression showed that the mosaic HBc was mainly in the form of inclusion bodies. After denaturation with urea, it was dialyzed progressively for protein renaturation. We observed that before and after renaturation, mosaic HBc was antigenic as determined by HBsAg ELISA and a lot of viruslike particles were observed after renaturation. Thus, we further purified the mosaic viruslike particles by (NH{sub 4}){sub 2}SO{sub 4} precipitation, DEAE chromatography, and Sepharose 4FF chromatography. Negative staining electron microscopy demonstrated the morphology of the viruslike particles. Immunization of Balb/c mice with mosaic particles induced the production of anti-HBs antibody and Th1 cell immune response supported by ELISPOT and CD4/CD8 proportions assay. In conclusion, we constructed mosaic hepatitis core particles displaying the entire ‘α’ antigenic determinant on the surface and laid a foundation for researching therapeutic hepatits B vaccines.
International Nuclear Information System (INIS)
Zhu Zuonong
2007-01-01
In this paper, we will concentrate on the topic of integrable discrete hierarchies in 2+1 dimensions, and their connection with discrete Painleve hierarchies. By considering a (2+1)-dimensional nonisospectral discrete linear problem, two new (2+1)-dimensional nonisospectral integrable lattice hierarchies-the 2+1 nonisospectral relativistic Toda lattice hierarchy and the 2+1 nonisospectral negative relativistic Toda lattice hierarchy-are constructed. It is shown that the reductions of the two new 2+1 nonisospectral lattice hierarchies lead to the (2+1)-dimensional nonisospectral Volterra lattice hierarchy and the (2+1)-dimensional nonisospectral negative Volterra lattice hierarchy. We also obtain two new (1+1)-dimensional nonisospectral integrable lattice hierarchies and two new ordinary difference hierarchies which are direct reductions of the two 2+1 nonisospectral integrable lattice hierarchies. One of the two difference hierarchies yields our previously obtained generalized discrete first Painleve (dP I ) hierarchy and another one yields a generalized alternative discrete second Painleve (alt-dP II ) hierarchy
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Directory of Open Access Journals (Sweden)
Liu Huaqing
2012-06-01
day post-injury is critical to the generation of tactile allodynia, neuroinflammation, and the immunodominant MBP digest peptides in nerve. These MBP peptides initiate mechanical allodynia in both a T cell-dependent and -independent manner. In the course of Wallerian degeneration, the repeated exposure of the cryptic MBP epitopes, which are normally sheltered from immunosurveillance, may induce the MBP-specific T cell clones and a self-sustaining immune reaction, which may together contribute to the transition of acute pain into a chronic neuropathic pain state.
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.
Liu, Huaqing; Shiryaev, Sergey A; Chernov, Andrei V; Kim, Youngsoon; Shubayev, Igor; Remacle, Albert G; Baranovskaya, Svetlana; Golubkov, Vladislav S; Strongin, Alex Y; Shubayev, Veronica I
2012-06-07
, neuroinflammation, and the immunodominant MBP digest peptides in nerve. These MBP peptides initiate mechanical allodynia in both a T cell-dependent and -independent manner. In the course of Wallerian degeneration, the repeated exposure of the cryptic MBP epitopes, which are normally sheltered from immunosurveillance, may induce the MBP-specific T cell clones and a self-sustaining immune reaction, which may together contribute to the transition of acute pain into a chronic neuropathic pain state.
A differential-difference hierarchy associated with relativistic Toda and Volterra hierarchies
International Nuclear Information System (INIS)
Fan Engui; Dai Huihui
2008-01-01
By embedding a free function into a compatible zero curvature equation, we enlarge the original differential-difference hierarchy into a new hierarchy with the free function which still admits zero curvature representation. The new hierarchy not only includes the original hierarchy, but also the well-known relativistic Toda hierarchy and the Volterra hierarchy as special reductions by properly choosing the free function. Infinitely many conservation laws and Darboux transformation for a representative differential-difference system are constructed based on its Lax representation. The exact solutions follow by applying the Darboux transformation
Hierarchy in fermion masses and the phantom axion
International Nuclear Information System (INIS)
Nanopoulos, D.V.
1981-01-01
An SU(5) model is presented with hierarchical fermion masses without strong CP violation and with an almost unobservable axion. The key point is to ''tie'' the highly desirable U(1)sub(P-Q) symmetry to the symmetry needed for the fermion mass hierarchy. Since the symmetry is broken at super-high energies (10 15 GeV), the axion becomes super-difficult to detect. This is the Phantom Axion. (author)
Explaining focal points: Cognitive hierarchy theory versus team reasoning
Bardsley, Nicholas; Mehta, Judith; Starmer, Chris; Sugden, Robert
2008-01-01
This paper reports experimental tests of two alternative explanations of how players use focal points to select equilibria in one-shot coordination games. Cognitive hierarchy theory explains coordination as the result of common beliefs about players’ pre-reflective inclinations towards the relevant strategies; the theory of team reasoning explains it as the result of the players’ using a non-standard form of reasoning. We report two experiments. One finds strong support for team reasoning; th...
Neutrino mass matrix and hierarchy
International Nuclear Information System (INIS)
Kaus, Peter; Meshkov, Sydney
2003-01-01
We build a model to describe neutrinos based on strict hierarchy, incorporating as much as possible, the latest known data, for Δsol and Δatm, and for the mixing angles determined from neutrino oscillation experiments, including that from KamLAND. Since the hierarchy assumption is a statement about mass ratios, it lets us obtain all three neutrino masses. We obtain a mass matrix, Mν and a mixing matrix, U, where both Mν and U are given in terms of powers of Λ, the analog of the Cabibbo angle λ in the Wolfenstein representation, and two parameters, ρ and κ, each of order one. The expansion parameter, Λ, is defined by Λ2 = m2/m3 = √(Δsol/Δatm) ≅ 0.16, and ρ expresses our ignorance of the lightest neutrino mass m1, (m1 ρΛ4m3), while κ scales s13 to the experimental upper limit, s13 = κΛ2 ≅ 0.16κ. These matrices are similar in structure to those for the quark and lepton families, but with Λ about 1.6 times larger than the λ for the quarks and charged leptons. The upper limit for the effective neutrino mass in double β-decay experiments is 4 x 10-3eV if s13 = 0 and 6 x 10-3eV if s13 is maximal. The model, which is fairly unique, given the hierarchy assumption and the data, is compared to supersymmetric extension and texture zero models of mass generation
Generalized NLS hierarchies from rational W algebras
International Nuclear Information System (INIS)
Toppan, F.
1993-11-01
Finite rational W algebras are very natural structures appearing in coset constructions when a Kac-Moody subalgebra is factored out. The problem of relating these algebras to integrable hierarchies of equations is studied by showing how to associate to a rational W algebra its corresponding hierarchy. Two examples are worked out, the sl(2)/U(1) coset, leading to the Non-Linear Schroedinger hierarchy, and the U(1) coset of the Polyakov-Bershadsky W algebra, leading to a 3-field representation of the KP hierarchy already encountered in the literature. In such examples a rational algebra appears as algebra of constraints when reducing a KP hierarchy to a finite field representation. This fact arises the natural question whether rational algebras are always associated to such reductions and whether a classification of rational algebras can lead to a classification of the integrable hierarchies. (author). 19 refs
Neutrino mass hierarchy and matter effects
Smirnov, Alexei Yu.
2013-01-01
Matter effects modify the mixing and the effective masses of neutrinos in a way which depends on the neutrino mass hierarchy. Consequently, for normal and inverted hierarchies the oscillations and flavor conversion results are different. Sensitivity to the mass hierarchy appears whenever the matter effects on the 1-3 mixing and mass splitting become substantial. This happens in supernovae in wide energy range and in the matter of the Earth. The Earth density profile is a multi-layer medium wh...
Hierarchy is Detrimental for Human Cooperation
Cronin, Katherine A.; Acheson, Daniel J.; Hernández, Penélope; Sánchez, Angel
2016-01-01
Studies of animal behavior consistently demonstrate that the social environment impacts cooperation, yet the effect of social dynamics has been largely excluded from studies of human cooperation. Here, we introduce a novel approach inspired by nonhuman primate research to address how social hierarchies impact human cooperation. Participants competed to earn hierarchy positions and then could cooperate with another individual in the hierarchy by investing in a common effort. Cooperation was ac...
Hierarchy stability for spontaneously broken theories
Energy Technology Data Exchange (ETDEWEB)
Galvan, J B; Perez-Mercader, J; Sanchez, F J
1987-04-16
By using Weisberger's method for the integration of heavy degrees of freedom in multiscale theories, we show that tree level hierarchies are not destabilized byquantum corrections in a two-scale, two scalar field theory model where the heavy sector undergoes spontaneous symmetry breaking. We see explicitly the role played by the one-loop heavy log corrections to the effective parameters in maintaining the original tree level hierarchy and in keeping the theory free of hierarchy problems.
A lattice hierarchy and its continuous limits
International Nuclear Information System (INIS)
Fan Engui
2008-01-01
By introducing a discrete spectral problem, we derive a lattice hierarchy which is integrable in Liouville's sense and possesses a multi-Hamiltonian structure. It is show that the discrete spectral problem converges to the well-known AKNS spectral problem under a certain continuous limit. In particular, we construct a sequence of equations in the lattice hierarchy which approximates the AKNS hierarchy as a continuous limit
Hierarchy stability for spontaneously broken theories
International Nuclear Information System (INIS)
Galvan, J.B.; Perez-Mercader, J.; Sanchez, F.J.
1987-01-01
By using Weisberger's method for the integration of heavy degrees of freedom in multiscale theories, we show that tree level hierarchies are not destabilized byquantum corrections in a two-scale, two scalar field theory model where the heavy sector undergoes spontaneous symmetry breaking. We see explicitly the role played by the one-loop heavy log corrections to the effective parameters in maintaining the original tree level hierarchy and in keeping the theory free of hierarchy problems. (orig.)
Directory of Open Access Journals (Sweden)
Annette Pachnio
Full Text Available Cytomegalovirus (CMV infects the majority of the global population and leads to the development of a strong virus-specific immune response. The CMV-specific CD4+ and CD8+ T cell immune response can comprise between 10 and 50% of the T cell pool within peripheral blood and there is concern that this may impair immunity to other pathogens. Elderly individuals with the highest magnitude of CMV-specific immune response have been demonstrated to be at increased risk of mortality and there is increasing interest in interventions that may serve to moderate this. Acyclovir is an anti-viral drug with activity against a range of herpes viruses and is used as long term treatment to suppress reactivation of herpes simplex virus. We studied the immune response to CMV in patients who were taking acyclovir to assess if therapy could be used to suppress the CMV-specific immune response. The T cell reactivity against the immunodominant late viral protein pp65 was reduced by 53% in people who were taking acyclovir. This effect was seen within one year of therapy and was observed primarily within the CD4+ response. Acyclovir treatment only modestly influenced the immune response to the IE-1 target protein. These data show that low dose acyclovir treatment has the potential to modulate components of the T cell response to CMV antigen proteins and indicate that anti-viral drugs should be further investigated as a means to reduce the magnitude of CMV-specific immune response and potentially improve overall immune function.
Two New Multi-component BKP Hierarchies
International Nuclear Information System (INIS)
Wu Hongxia; Liu Xiaojun; Zeng Yunbo
2009-01-01
We firstly propose two kinds of new multi-component BKP (mcBKP) hierarchy based on the eigenfunction symmetry reduction and nonstandard reduction, respectively. The first one contains two types of BKP equation with self-consistent sources whose Lax representations are presented. The two mcBKP hierarchies both admit reductions to the k-constrained BKP hierarchy and to integrable (1+1)-dimensional hierarchy with self-consistent sources, which include two types of SK equation with self-consistent sources and of bi-directional SK equations with self-consistent sources.
Directory of Open Access Journals (Sweden)
Zhuo Zhao
Full Text Available Staphylococcal enterotoxin B (SEB is one of the most potent Staphylococcus aureus exotoxins (SEs. Due to its conserved sequence and stable structure, SEB might be a good candidate antigen for MRSA vaccines. Although cellular immune responses to SEB are well-characterized, much less is known regarding SEB-specific humoral immune responses, particularly regarding detailed epitope mapping. In this study, we utilized a recombinant nontoxic mutant of SEB (rSEB and an AlPO4 adjuvant to immunize BALB/c mice and confirmed that rSEB can induce a high antibody level and effective immune protection against MRSA infection. Next, the antisera of immunized mice were collected, and linear B cell epitopes within SEB were finely mapped using a series of overlapping synthetic peptides. Three immunodominant B cell epitopes of SEB were screened by ELISA, including a novel epitope, SEB205-222, and two known epitopes, SEB97-114 and SEB247-261. Using truncated peptides, an ELISA was performed with peptide-KLH antisera, and the core sequence of the three immunodominant B cell epitopes were verified as SEB97-112, SEB207-222, and SEB247-257. In vitro, all of the immunodominant epitope-specific antisera (anti-SEB97-112, anti-SEB207-222 and anti-SEB247-257 were observed to inhibit SEB-induced T cell mitogenesis and cytokine production from splenic lymphocytes of BALB/c mice. The homology analysis indicated that SEB97-112 and SEB207-222 were well-conserved among different Staphylococcus aureus strains. The 3D crystal structure of SEB indicated that SEB97-112 was in the loop region inside SEB, whereas SEB207-222 and SEB247-257 were in the β-slice region outside SEB. In summary, the fine-mapping of linear B-cell epitopes of the SEB antigen in this study will be useful to understand anti-SEB immunity against MRSA infection further and will be helpful to optimize MRSA vaccine designs that are based on the SEB antigen.
On the robustness of Herlihy's hierarchy
Jayanti, Prasad
1993-01-01
A wait-free hierarchy maps object types to levels in Z(+) U (infinity) and has the following property: if a type T is at level N, and T' is an arbitrary type, then there is a wait-free implementation of an object of type T', for N processes, using only registers and objects of type T. The infinite hierarchy defined by Herlihy is an example of a wait-free hierarchy. A wait-free hierarchy is robust if it has the following property: if T is at level N, and S is a finite set of types belonging to levels N - 1 or lower, then there is no wait-free implementation of an object of type T, for N processes, using any number and any combination of objects belonging to the types in S. Robustness implies that there are no clever ways of combining weak shared objects to obtain stronger ones. Contrary to what many researchers believe, we prove that Herlihy's hierarchy is not robust. We then define some natural variants of Herlihy's hierarchy, which are also infinite wait-free hierarchies. With the exception of one, which is still open, these are not robust either. We conclude with the open question of whether non-trivial robust wait-free hierarchies exist.
Models of neutrino masses: Anarchy versus hierarchy
International Nuclear Information System (INIS)
Altarelli, Guido; Feruglio, Ferruccio; Masina, Isabella
2003-01-01
We present a quantitative study of the ability of models with different levels of hierarchy to reproduce the solar neutrino solutions, in particular the LA solution. As a flexible testing ground we consider models based on SU(5)xU(1) F . In this context, we have made statistical simulations of models with different patterns from anarchy to various types of hierarchy: normal hierarchical models with and without automatic suppression of the 23 (sub)determinant and inverse hierarchy models. We find that, not only for the LOW or VO solutions, but even in the LA case, the hierarchical models have a significantly better success rate than those based on anarchy. The normal hierarchy and the inverse hierarchy models have comparable performances in models with see-saw dominance, while the inverse hierarchy models are particularly good in the no see-saw versions. As a possible distinction between these categories of models, the inverse hierarchy models favour a maximal solar mixing angle and their rate of success drops dramatically as the mixing angle decreases, while normal hierarchy models are far more stable in this respect. (author)
Coupling Integrable Couplings of an Equation Hierarchy
International Nuclear Information System (INIS)
Wang Hui; Xia Tie-Cheng
2013-01-01
Based on a kind of Lie algebra G proposed by Zhang, one isospectral problem is designed. Under the framework of zero curvature equation, a new kind of integrable coupling of an equation hierarchy is generated using the methods proposed by Ma and Gao. With the help of variational identity, we get the Hamiltonian structure of the hierarchy. (general)
A Suggested Modification to Maslow's Need Hierarchy
Groves, David L.; And Others
1975-01-01
Since its development, Maslow's need hierarchy has been criticized and applauded. This investigation was undertaken to explore a modification of the upper levels of the need hierarchy based upon the application of power, competition, and achievement to self, as well as the concept of "other directed." (Author)
Solution of the gauge hierarchy problem
International Nuclear Information System (INIS)
Dimopoulos, S.; Georgi, H.
1982-01-01
We propose a novel solution to the gauge hierarchy problem in theories with softly broken supersymmetry. Quantum effects can resuscitate classically sick theories, producing the large scale from the small supersymmetry breaking scale. We use this mechanism to construct realistic SU(6) and SU(5) GUTs which do not suffer from gauge hierarchy or fine tuning problems. (orig.)
q-Deformed KP Hierarchy and q-Deformed Constrained KP Hierarchy
He, Jingsong; Li, Yinghua; Cheng, Yi
2006-01-01
Using the determinant representation of gauge transformation operator, we have shown that the general form of $au$ function of the $q$-KP hierarchy is a $q$-deformed generalized Wronskian, which includes the $q$-deformed Wronskian as a special case. On the basis of these, we study the $q$-deformed constrained KP ($q$-cKP) hierarchy, i.e. $l$-constraints of $q$-KP hierarchy. Similar to the ordinary constrained KP (cKP) hierarchy, a large class of solutions of $q$-cKP hierarchy can be represent...
Mass hierarchies from anomalies: A peek behind the Planck curtain
International Nuclear Information System (INIS)
Ramond, P.
1996-01-01
The masses of quarks and leptons suggest a strong hierarchical structure. We argue that their patterns can be reproduced through the introduction of a new Abelian symmetry. The data suggest that this symmetry is anomalous. We suggest that the cancellation of its anomalies occurs through the Green-Schwarz mechanism. An important check of this idea is that it links the Weinberg angle to a mass ration of the elementary fermions. The Green-Schwarz mechanism occurs naturally in many superstring compactifications, and produces a small parameter, which we use to determine the quark mass hierarchy. We show that hierarchy and mixings among the chiral fermions is a consequence of the Green-Schwarz mechanism. We present several models where this idea is realized. 16 refs., 2 tabs
Son, Soo Jung; Harris, Paul W R; Squire, Chris J; Baker, Edward N; Brimble, Margaret A
2016-05-01
Tuberculosis, the second leading cause of death from a single infectious agent, is recognized as a major threat to human health due to a lack of practicable vaccines against the disease and the widespread occurrence of drug resistance. With a pressing need for a novel protein target as a platform for new vaccine development, ESX-1 Substrate Protein C (EspC) was recently identified as a novel Mycobacterium tuberculosis-secreted antigen that is as immunodominant as the two specific immunodiagnostic T-cell antigens, CFP-10 and ESAT-6. Here, we present the first chemical total synthesis, folding conditions, and circular dichroism data of EspC. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 267-274, 2016. © 2016 Wiley Periodicals, Inc.
Is there a hierarchy of survival reflexes?
Macphail, Kieran
2013-10-01
A hierarchy of survival reflexes for prioritising assessment and treatment in patients with pain of insidious onset is hypothesised. The hierarchy asserts that some systems are more vital than others and that the central nervous system (CNS) prioritises systems based on their significance to survival. The hypothesis suggests that dysfunction in more important systems will cause compensation in less important systems. This paper presents studies examining these effects for each system, arguing that each section of the hierarchy may have effects on other systems within the hierarchy. This concept is untested empirically, highly speculative and substantial research is required to validate the suggested hierarchical prioritisation by the CNS. Nonetheless, the hierarchy does provide a theoretical framework to use to exclude contributing systems in patients with pain of insidious onset. Copyright © 2013 Elsevier Ltd. All rights reserved.
Constrained KP models as integrable matrix hierarchies
International Nuclear Information System (INIS)
Aratyn, H.; Ferreira, L.A.; Gomes, J.F.; Zimerman, A.H.
1997-01-01
We formulate the constrained KP hierarchy (denoted by cKP K+1,M ) as an affine [cflx sl](M+K+1) matrix integrable hierarchy generalizing the Drinfeld endash Sokolov hierarchy. Using an algebraic approach, including the graded structure of the generalized Drinfeld endash Sokolov hierarchy, we are able to find several new universal results valid for the cKP hierarchy. In particular, our method yields a closed expression for the second bracket obtained through Dirac reduction of any untwisted affine Kac endash Moody current algebra. An explicit example is given for the case [cflx sl](M+K+1), for which a closed expression for the general recursion operator is also obtained. We show how isospectral flows are characterized and grouped according to the semisimple non-regular element E of sl(M+K+1) and the content of the center of the kernel of E. copyright 1997 American Institute of Physics
Initial states in integrable quantum field theory quenches from an integral equation hierarchy
Directory of Open Access Journals (Sweden)
D.X. Horváth
2016-01-01
Full Text Available We consider the problem of determining the initial state of integrable quantum field theory quenches in terms of the post-quench eigenstates. The corresponding overlaps are a fundamental input to most exact methods to treat integrable quantum quenches. We construct and examine an infinite integral equation hierarchy based on the form factor bootstrap, proposed earlier as a set of conditions determining the overlaps. Using quenches of the mass and interaction in Sinh-Gordon theory as a concrete example, we present theoretical arguments that the state has the squeezed coherent form expected for integrable quenches, and supporting an Ansatz for the solution of the hierarchy. Moreover we also develop an iterative method to solve numerically the lowest equation of the hierarchy. The iterative solution along with extensive numerical checks performed using the next equation of the hierarchy provides a strong numerical evidence that the proposed Ansatz gives a very good approximation for the solution.
Initial states in integrable quantum field theory quenches from an integral equation hierarchy
Energy Technology Data Exchange (ETDEWEB)
Horváth, D.X., E-mail: esoxluciuslinne@gmail.com [MTA-BME “Momentum” Statistical Field Theory Research Group, Budafoki út 8, 1111 Budapest (Hungary); Department of Theoretical Physics, Budapest University of Technology and Economics, Budafoki út 8, 1111 Budapest (Hungary); Sotiriadis, S., E-mail: sotiriad@sissa.it [SISSA and INFN, Via Bonomea 265, 34136 Trieste (Italy); Takács, G., E-mail: takacsg@eik.bme.hu [MTA-BME “Momentum” Statistical Field Theory Research Group, Budafoki út 8, 1111 Budapest (Hungary); Department of Theoretical Physics, Budapest University of Technology and Economics, Budafoki út 8, 1111 Budapest (Hungary)
2016-01-15
We consider the problem of determining the initial state of integrable quantum field theory quenches in terms of the post-quench eigenstates. The corresponding overlaps are a fundamental input to most exact methods to treat integrable quantum quenches. We construct and examine an infinite integral equation hierarchy based on the form factor bootstrap, proposed earlier as a set of conditions determining the overlaps. Using quenches of the mass and interaction in Sinh-Gordon theory as a concrete example, we present theoretical arguments that the state has the squeezed coherent form expected for integrable quenches, and supporting an Ansatz for the solution of the hierarchy. Moreover we also develop an iterative method to solve numerically the lowest equation of the hierarchy. The iterative solution along with extensive numerical checks performed using the next equation of the hierarchy provides a strong numerical evidence that the proposed Ansatz gives a very good approximation for the solution.
DEFF Research Database (Denmark)
Katajainen, Jyrki
2008-01-01
In this project the goal is to develop the safe * family of containers for the CPH STL. The containers to be developed should be safer and more reliable than any of the existing implementations. A special focus should be put on strong exception safety since none of the existing prototypes available...
Hierarchy is Detrimental for Human Cooperation
Cronin, Katherine A.; Acheson, Daniel J.; Hernández, Penélope; Sánchez, Angel
2015-01-01
Studies of animal behavior consistently demonstrate that the social environment impacts cooperation, yet the effect of social dynamics has been largely excluded from studies of human cooperation. Here, we introduce a novel approach inspired by nonhuman primate research to address how social hierarchies impact human cooperation. Participants competed to earn hierarchy positions and then could cooperate with another individual in the hierarchy by investing in a common effort. Cooperation was achieved if the combined investments exceeded a threshold, and the higher ranked individual distributed the spoils unless control was contested by the partner. Compared to a condition lacking hierarchy, cooperation declined in the presence of a hierarchy due to a decrease in investment by lower ranked individuals. Furthermore, hierarchy was detrimental to cooperation regardless of whether it was earned or arbitrary. These findings mirror results from nonhuman primates and demonstrate that hierarchies are detrimental to cooperation. However, these results deviate from nonhuman primate findings by demonstrating that human behavior is responsive to changing hierarchical structures and suggests partnership dynamics that may improve cooperation. This work introduces a controlled way to investigate the social influences on human behavior, and demonstrates the evolutionary continuity of human behavior with other primate species. PMID:26692287
Hierarchy is Detrimental for Human Cooperation.
Cronin, Katherine A; Acheson, Daniel J; Hernández, Penélope; Sánchez, Angel
2015-12-22
Studies of animal behavior consistently demonstrate that the social environment impacts cooperation, yet the effect of social dynamics has been largely excluded from studies of human cooperation. Here, we introduce a novel approach inspired by nonhuman primate research to address how social hierarchies impact human cooperation. Participants competed to earn hierarchy positions and then could cooperate with another individual in the hierarchy by investing in a common effort. Cooperation was achieved if the combined investments exceeded a threshold, and the higher ranked individual distributed the spoils unless control was contested by the partner. Compared to a condition lacking hierarchy, cooperation declined in the presence of a hierarchy due to a decrease in investment by lower ranked individuals. Furthermore, hierarchy was detrimental to cooperation regardless of whether it was earned or arbitrary. These findings mirror results from nonhuman primates and demonstrate that hierarchies are detrimental to cooperation. However, these results deviate from nonhuman primate findings by demonstrating that human behavior is responsive to changing hierarchical structures and suggests partnership dynamics that may improve cooperation. This work introduces a controlled way to investigate the social influences on human behavior, and demonstrates the evolutionary continuity of human behavior with other primate species.
International Nuclear Information System (INIS)
Froissart, Marcel
1976-01-01
Strong interactions are introduced by their more obvious aspect: nuclear forces. In hadron family, the nucleon octet, OMEGA - decuplet, and quark triply are successively considered. Pion wave having been put at the origin of nuclear forces, low energy phenomena are described, the force being explained as an exchange of structure corresponding to a Regge trajectory in a variable rotating state instead of the exchange of a well defined particle. At high energies the concepts of pomeron, parton and stratons are introduced, pionization and fragmentation are briefly differentiated [fr
Formal language theory: refining the Chomsky hierarchy.
Jäger, Gerhard; Rogers, James
2012-07-19
The first part of this article gives a brief overview of the four levels of the Chomsky hierarchy, with a special emphasis on context-free and regular languages. It then recapitulates the arguments why neither regular nor context-free grammar is sufficiently expressive to capture all phenomena in the natural language syntax. In the second part, two refinements of the Chomsky hierarchy are reviewed, which are both relevant to the extant research in cognitive science: the mildly context-sensitive languages (which are located between context-free and context-sensitive languages), and the sub-regular hierarchy (which distinguishes several levels of complexity within the class of regular languages).
A quark interpretation of the combinatorial hierarchy
International Nuclear Information System (INIS)
Enqvist, Kari.
1979-01-01
We propose a physical interpretation of the second level of the combinatorial hierarchy in terms of three quarks, three antiquarks and the vacuum. This interpretation allows us to introduce a new quantum number, which measures electromagnetic mass splitting of the quarks. We extend our argument by analogue to baryons, and find some SU(3) and some new mass formulas for baryons. The generalization of our approach to other hierarchy levels is discussed. We present also an empirical mass formula for baryons, which seems to be loosely connected with the combinatorial hierarchy. (author)
Cognitive Hierarchy Theory and Two-Person Games
Directory of Open Access Journals (Sweden)
Carlos Gracia-Lázaro
2017-01-01
Full Text Available The outcome of many social and economic interactions, such as stock-market transactions, is strongly determined by the predictions that agents make about the behavior of other individuals. Cognitive hierarchy theory provides a framework to model the consequences of forecasting accuracy that has proven to fit data from certain types of game theory experiments, such as Keynesian beauty contests and entry games. Here, we focus on symmetric two-player-two-action games and establish an algorithm to find the players’ strategies according to the cognitive hierarchy approach. We show that the snowdrift game exhibits a pattern of behavior whose complexity grows as the cognitive levels of players increases. In addition to finding the solutions up to the third cognitive level, we demonstrate, in this theoretical frame, two new properties of snowdrift games: (i any snowdrift game can be characterized by only a parameter, its class; (ii they are anti-symmetric with respect to the diagonal of the pay-off’s space. Finally, we propose a model based on an evolutionary dynamics that captures the main features of the cognitive hierarchy theory.
Sex-specific mechanism of social hierarchy in mice.
van den Berg, Wouter E; Lamballais, Sander; Kushner, Steven A
2015-05-01
The establishment of social hierarchies is a naturally occurring, evolutionarily conserved phenomenon with a well-established impact on fitness and health. Investigations of complex social group dynamics may offer novel opportunities for translational studies of autism spectrum disorder. Here we describe a robust behavioral paradigm using an automated version of the tube test. Isogenic groups of male and female mice establish linear social hierarchies that remain highly stable for at least 14 days, the longest interval tested. Remarkably, however, their social strategy is sex-specific: females primarily utilize intrinsic attributes, whereas males are strongly influenced by prior social experience. Using both genetic and pharmacological manipulations, we identify testosterone as a critical sex-specific factor for determining which social strategy is used. Males inheriting a null mutation of the sex-determining region Y (Sry) gene used a similar social cognitive strategy as females. In contrast, females with transgenic expression of Sry utilized a typically male social strategy. Analogously, castration of males and testosterone supplementation of females yielded similar outcomes, with a reversal of their social cognitive strategy. Together, our results demonstrate a sex-specific mechanism underlying social hierarchy, in which both males and females retain the functional capacity to adapt their social strategy. More generally, we expect the automated tube test to provide an important complementary approach for both fundamental and translational studies of social behavior.
Hierarchy of modular graph identities
International Nuclear Information System (INIS)
D’Hoker, Eric; Kaidi, Justin
2016-01-01
The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.
Sniffing behavior communicates social hierarchy.
Wesson, Daniel W
2013-04-08
Sniffing is a specialized respiratory behavior that is essential for the acquisition of odors [1-4]. Perhaps not independent of this, sniffing is commonly displayed during motivated [5-7] and social behaviors [8, 9]. No measures of sniffing among interacting animals are available, however, calling into question the utility of this behavior in the social context. From radiotelemetry recordings of nasal respiration, I found that investigation by one rat toward the facial region of a conspecific often elicits a decrease in sniffing frequency in the conspecific. This reciprocal display of sniffing was found to be dependent upon the rat's social status in two separate paradigms, with subordinates reliably decreasing their sniffing frequency upon being investigated in the face by dominant rats. Failure of subordinates to decrease their sniffing frequency shortened the latency for agonistic behavior by dominant rats, reflecting that decreases in sniffing serve as appeasement signals during social interactions. Rats rendered unable to smell persisted in displaying reciprocal sniffing behavior, demonstrating the independence of this behavior from olfaction. Oxytocin treatment in rats with established social hierarchies abolished agonistic behaviors and reciprocal sniffing displays. Together, these findings demonstrate that rodents utilize sniffing behaviors communicatively, not only to collect [6, 10-14] but also to convey information. Copyright © 2013 Elsevier Ltd. All rights reserved.
Hierarchy of modular graph identities
Energy Technology Data Exchange (ETDEWEB)
D’Hoker, Eric; Kaidi, Justin [Mani L. Bhaumik Institute for Theoretical Physics, Department of Physics and Astronomy,University of California,Los Angeles, CA 90095 (United States)
2016-11-09
The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.
Topological Strings and Integrable Hierarchies
Aganagic, M; Klemm, A D; Marino, M; Vafa, C; Aganagic, Mina; Dijkgraaf, Robbert; Klemm, Albrecht; Marino, Marcos; Vafa, Cumrun
2006-01-01
We consider the topological B-model on local Calabi-Yau geometries. We show how one can solve for the amplitudes by using W-algebra symmetries which encodes the symmetries of holomorphic diffeomorphisms of the Calabi-Yau. In the highly effective fermionic/brane formulation this leads to a free fermion description of the amplitudes. Furthermore we argue that topological strings on Calabi-Yau geometries provide a unifying picture connecting non-critical (super)strings, integrable hierarchies, and various matrix models. In particular we show how the ordinary matrix model, the double scaling limit of matrix models, and Kontsevich-like matrix model are all related and arise from studying branes in specific local Calabi-Yau three-folds. We also show how A-model topological string on P^1 and local toric threefolds (and in particular the topological vertex) can be realized and solved as B-model topological string amplitudes on a Calabi-Yau manifold.
Fermion hierarchy from sfermion anarchy
International Nuclear Information System (INIS)
Altmannshofer, Wolfgang; Frugiuele, Claudia; Harnik, Roni
2014-01-01
We present a framework to generate the hierarchical flavor structure of Standard Model quarks and leptons from loops of superpartners. The simplest model consists of the minimal supersymmetric standard model with tree level Yukawa couplings for the third generation only and anarchic squark and slepton mass matrices. Agreement with constraints from low energy flavor observables, in particular Kaon mixing, is obtained for supersymmetric particles with masses at the PeV scale or above. In our framework both the second and the first generation fermion masses are generated at 1-loop. Despite this, a novel mechanism generates a hierarchy among the first and second generations without imposing a symmetry or small parameters. A second-to-first generation mass ratio of order 100 is typical. The minimal supersymmetric standard model thus includes all the necessary ingredients to realize a fermion spectrum that is qualitatively similar to observation, with hierarchical masses and mixing. The minimal framework produces only a few quantitative discrepancies with observation, most notably the muon mass is too low. Furthermore, we discuss simple modifications which resolve this and also investigate the compatibility of our model with gauge and Yukawa coupling Unification
Brane world model and hierarchy problem
International Nuclear Information System (INIS)
Alba, V.
2007-01-01
In this paper I wrote description of Kaluza-Klein model. Also I wrote how we can solve the hierarchy problem in Randall-Sundrum model. In fact, it's my motivation to study this part of theoretical physics
Hierarchies of belief and interim rationalizability
Directory of Open Access Journals (Sweden)
Jeffrey C. Ely
2006-03-01
Full Text Available In games with incomplete information, conventional hierarchies of belief are incomplete as descriptions of the players' information for the purposes of determining a player's behavior. We show by example that this is true for a variety of solution concepts. We then investigate what is essential about a player's information to identify behavior. We specialize to two player games and the solution concept of interim rationalizability. We construct the universal type space for rationalizability and characterize the types in terms of their beliefs. Infinite hierarchies of beliefs over conditional beliefs, which we call Delta-hierarchies, are what turn out to matter. We show that any two types in any two type spaces have the same rationalizable sets in all games if and only if they have the same Delta-hierarchies.
Probing Neutrino Mass Hierarchy with Supernova
International Nuclear Information System (INIS)
Chakraborty, Sovan
2013-01-01
The rise time of electron antineutrino lightcurve from a Galactic supernova (SN), observable at the IceCube Cherenkov detector, can provide signature of the neutrino mass hierarchy at “large” 1-3 leptonic mixing angle ϑ 13 . In the early accretion phase of the SN, the neutrino oscillations are nontrivial. Due to the matter suppression of collective effects at these early post bounce times, only the MSW resonances in the outer layers of the SN influence the neutrino flux. When the oscillations are taken into account, the signal in IceCube shows sufficiently fast rise time for the inverted mass hierarchy compared to the normal hierarchy. An investigation with an extensive set of stellar core-collapse simulations, provides both qualitative and quantitative robustness of these features. Thus opening another avenue to explore the neutrino mass hierarchy with the rise time of a supernova burst
Planning hierarchy, modeling and sdvanced planning dystems
Meyr, Herbert Ottmar
2003-01-01
Planning hierarchy, modeling and sdvanced planning dystems / B. Fleischmann, H. Meyr. - In: Supply chain management / ed. by A. G. de Kok ... - Amsterdam u.a. : Elsevier, 2003. - (Handbooks in operations research and management science ; 11)
The multi-component WKI hierarchy
International Nuclear Information System (INIS)
Yao Yuqin; Zhang Yufeng
2005-01-01
Firstly a new loop algebra G∼ M with 3M dimensions is constructed, which is devoted to establishing a new isospectral problem. Then the multi-component WKI hierarchy of soliton equations is obtained
Improving Expression Power in Modeling OLAP Hierarchies
Malinowski, Elzbieta
Data warehouses and OLAP systems form an integral part of modern decision support systems. In order to exploit both systems to their full capabilities hierarchies must be clearly defined. Hierarchies are important in analytical applications, since they provide users with the possibility to represent data at different abstraction levels. However, even though there are different kinds of hierarchies in real-world applications and some are already implemented in commercial tools, there is still a lack of a well-accepted conceptual model that allows decision-making users express their analysis needs. In this paper, we show how the conceptual multidimensional model can be used to facilitate the representation of complex hierarchies in comparison to their representation in the relational model and commercial OLAP tool, using as an example Microsoft Analysis Services.
A hierarchy of Ramsey-like cardinals
Holy, Peter; Schlicht, Philipp
2017-01-01
We introduce a hierarchy of large cardinals between weakly compact and measurable cardinals, that is closely related to the Ramsey-like cardinals introduced by Victoria Gitman, and is based on certain infinite filter games, however also has a range of equivalent characterizations in terms of elementary embeddings. The aim of this paper is to locate the Ramsey-like cardinals studied by Gitman, and other well-known large cardinal notions, in this hierarchy.
Fermion mass hierarchies in theories of technicolor
International Nuclear Information System (INIS)
Peskin, M.E.
1981-01-01
Models in which light fermion masses result from dynamical symmetry breaking often produce these masses in a hierarchial pattern. The author exhibits two scenarios for obtaining such hierarchies and illustrates each with a simple model of mass generation. In the first scenario, the light fermion masses are separated by powers of a weak coupling constant; in the second scenario, they are separated by a ratio of large mass scales
Hierarchy among Automata on Linear Orderings
Bruyère , Véronique; Carton , Olivier
2005-01-01
In a preceding paper, automata and rational expressions have been introduced for words indexed by linear orderings, together with a Kleene-like theorem. We here pursue this work by proposing a hierarchy among the rational sets. Each class of the hierarchy is defined by a subset of the rational operations that can be used. We then characterize any class by an appropriate class of automata, leading to a Kleene theorem inside the class. A characterization by particular classes of orderings is al...
Shrinking population and the urban hierarchy
Kim, Ho Yeon
2012-01-01
This paper examines whether population shrinkage leads to changes in the urban hierarchy in terms of relative sizes of cities and their functions onomic geography. We work backwards in a racetrack economy with eight cities in a long-run equilibrium. Initial distribution of population is chosen to satisfy both the rank-size rule and central place hierarchy. We have a short-run equilibrium in which firms choose prices and consumers choose consumption taking the number of workers in each region ...
Hierarchy generation in compactified supersymmetric models
International Nuclear Information System (INIS)
Ross, G.G.
1988-01-01
The problem of generating a large hierarchy in compactified supersymmetric models is re-examined. It is shown how, even for the class of models for which Str M 2 is non-vanishing, a combination of non-perturbative effects and radiative corrections may lead to an exponentially large hierarchy. A corollary is that the couplings of the effective field theory in the visible sector should be small, i.e., perturbation theory should be applicable. (orig.)
Learning of Alignment Rules between Concept Hierarchies
Ichise, Ryutaro; Takeda, Hideaki; Honiden, Shinichi
With the rapid advances of information technology, we are acquiring much information than ever before. As a result, we need tools for organizing this data. Concept hierarchies such as ontologies and information categorizations are powerful and convenient methods for accomplishing this goal, which have gained wide spread acceptance. Although each concept hierarchy is useful, it is difficult to employ multiple concept hierarchies at the same time because it is hard to align their conceptual structures. This paper proposes a rule learning method that inputs information from a source concept hierarchy and finds suitable location for them in a target hierarchy. The key idea is to find the most similar categories in each hierarchy, where similarity is measured by the κ(kappa) statistic that counts instances belonging to both categories. In order to evaluate our method, we conducted experiments using two internet directories: Yahoo! and LYCOS. We map information instances from the source directory into the target directory, and show that our learned rules agree with a human-generated assignment 76% of the time.
Evaluating, Comparing, and Interpreting Protein Domain Hierarchies
2014-01-01
Abstract Arranging protein domain sequences hierarchically into evolutionarily divergent subgroups is important for investigating evolutionary history, for speeding up web-based similarity searches, for identifying sequence determinants of protein function, and for genome annotation. However, whether or not a particular hierarchy is optimal is often unclear, and independently constructed hierarchies for the same domain can often differ significantly. This article describes methods for statistically evaluating specific aspects of a hierarchy, for probing the criteria underlying its construction and for direct comparisons between hierarchies. Information theoretical notions are used to quantify the contributions of specific hierarchical features to the underlying statistical model. Such features include subhierarchies, sequence subgroups, individual sequences, and subgroup-associated signature patterns. Underlying properties are graphically displayed in plots of each specific feature's contributions, in heat maps of pattern residue conservation, in “contrast alignments,” and through cross-mapping of subgroups between hierarchies. Together, these approaches provide a deeper understanding of protein domain functional divergence, reveal uncertainties caused by inconsistent patterns of sequence conservation, and help resolve conflicts between competing hierarchies. PMID:24559108
Solutions of the bigraded Toda hierarchy
International Nuclear Information System (INIS)
Li Chuanzhong
2011-01-01
The (N, M)-bigraded Toda hierarchy is an extension of the original Toda lattice hierarchy. The pair of numbers (N, M) represents the band structure of the Lax matrix which has N upper and M lower diagonals, and the original one is referred to as the (1, 1)-bigraded Toda hierarchy. Because of this band structure, one can introduce M + N - 1 commuting flows which give a parametrization of a small phase space for a topological field theory. In this paper, first we show that there exists a natural symmetry between the (N, M)- and (M, N)-bigraded Toda hierarchies. We then derive the Hirota bilinear form for those commuting flows, which consist of two-dimensional Toda hierarchy, the discrete KP hierarchy and its Baecklund transformations. We also discuss the solution structure of the (N, M)-bigraded Toda equation in terms of the moment matrix defined via the wave operators associated with the Lax operator and construct some of the explicit solutions. In particular, we give the rational solutions which are expressed by the products of the Schur polynomials corresponding to the non-rectangular Young diagrams.
Cluster-cluster correlations and constraints on the correlation hierarchy
Hamilton, A. J. S.; Gott, J. R., III
1988-01-01
The hypothesis that galaxies cluster around clusters at least as strongly as they cluster around galaxies imposes constraints on the hierarchy of correlation amplitudes in hierachical clustering models. The distributions which saturate these constraints are the Rayleigh-Levy random walk fractals proposed by Mandelbrot; for these fractal distributions cluster-cluster correlations are all identically equal to galaxy-galaxy correlations. If correlation amplitudes exceed the constraints, as is observed, then cluster-cluster correlations must exceed galaxy-galaxy correlations, as is observed.
Mirror quintic vacua: hierarchies and inflation
Energy Technology Data Exchange (ETDEWEB)
Bizet, Nana Cabo [Mandelstam Institute for Theoretical Physics, School of Physics,and NITheP, University of the Witwatersrand, WITS 2050, Johannesburg (South Africa); Departamento de Física, Universidad de Guanajuato,Loma del Bosque 103, CP 37150, León, Guanajuato (Mexico); Loaiza-Brito, Oscar [Departamento de Física, Universidad de Guanajuato,Loma del Bosque 103, CP 37150, León, Guanajuato (Mexico); Zavala, Ivonne [Department of Physics, Swansea University, Singleton Park,Swansea, SA2 8PP (United Kingdom)
2016-10-17
We study the moduli space of type IIB string theory flux compactifications on the mirror of the CY quintic 3-fold in ℙ{sup 4}. We focus on the dynamics of the four dimensional moduli space, defined by the axio-dilaton τ and the complex structure modulus z. The z-plane has critical points, the conifold, the orbifold and the large complex structure with non trivial monodromies. We find the solutions to the Picard-Fuchs equations obeyed by the periods of the CY in the full z-plane as a series expansion in z around the critical points to arbitrary order. This allows us to discard fake vacua, which appear as a result of keeping only the leading order term in the series expansions. Due to monodromies vacua are located at a given sheet in the z-plane. A dS vacuum appears for a set of fluxes. We revisit vacua with hierarchies among the 4D and 6D physical scales close to the conifold point and compare them with those found at leading order in http://dx.doi.org/10.1103/PhysRevD.66.106006, http://dx.doi.org/10.1007/JHEP03(2011)119. We explore slow-roll inflationary directions of the scalar potential by looking at regions where the multi-field slow-roll parameters ϵ and η are smaller than one. The value of ϵ depends strongly on the approximation of the periods and to achieve a stable value, several orders in the expansion are needed. We do not find realizations of single field axion monodromy inflation. Instead, we find that inflationary regions appear along linear combinations of the four real field directions and for certain configurations of fluxes.
Rana, Aarti; Thakur, Shweta; Bhardwaj, Nupur; Kumar, Devender; Akhter, Yusuf
2016-12-01
For centuries, Mycobacterium leprae, etiological agent of leprosy, has been afflicting mankind regardless of extensive use of live-attenuated vaccines and antibiotics. Surface-associated and secretory proteins (SASPs) are attractive targets against bacteria. We have integrated biological knowledge with computational approaches and present a proteome-wide identification of SASPs. We also performed computational assignment of immunodominant epitopes as coordinates of prospective antigenic candidates in most important class of SASPs, the outer membrane proteins (OMPs). Exploiting the known protein sequence and structural characteristics shared by the SASPs from bacteria, 17 lipoproteins, 11 secretory and 19 novel OMPs (including 4 essential proteins) were identified in M. leprae As OMPs represent the most exposed antigens on the cell surface, their immunoinformatics analysis showed that the identified 19 OMPs harbor T-cell MHC class I epitopes and class II epitopes against HLA-DR alleles (54), while 15 OMPs present potential T-cell class II epitopes against HLA-DQ alleles (6) and 7 OMPs possess T-cell class II epitopes against HLA-DP alleles (5) of humans. Additionally, 11 M. leprae OMPs were found to have B-cell epitopes and these may be considered as prime candidates for the development of new immunotherapeutics against M. leprae. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
International Nuclear Information System (INIS)
Palker, T.J.; Matthews, T.J.; Clark, M.E.
1987-01-01
A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg). Peptide SP-22 absorbed up to 100% of anti-gp120 antibody reactivity from select HIV + patient sera in immunoblot assays and up to 79% of serum anti-gp120 antibody reactivity in competition RIA. In RIA, 45% of HIV-seropositive subjects had antibodies that bound to peptide SP-22. Human anti-SP-22 antibodies that bound to and were eluted from an SP-22 affinity column reacted with gp120 in RIA and immunoblot assays but did not neutralize HIV or inhibit HIV-induced syncytium formation in vitro, even though these antibodies comprised 70% of all anti-gp120 antibodies in the test serum. In contrast, the remaining 30% of SP-22 nonreactive anti-gp120 antibodies did not react with gp120 in immunoblot assays but did react in RIA and neutralized HIV in vitro. Thus, ≅ 50% of HIV-seropositive patients make high titers of nonneutralizing antibodies to an immunodominant antigen on gp120 defined by SP-22. Moreover, the COOH terminus of gp120 contains the major antigen or antigens identified by human anti-gp120 antibodies in immunoblot assays
M.E. Schouten (Maartje)
2016-01-01
markdownabstractScholars have assumed that social hierarchies, the rank ordering of individuals with respect to a valued social dimension within a team, are stable over time. However, hierarchies change and the more changeable they are, the more likely they are to lead to conflicts and have other
Constraints and Soliton Solutions for KdV Hierarchy and AKNS Hierarchy
International Nuclear Information System (INIS)
Li Nianhua; Li Yuqi
2011-01-01
It is well-known that the finite-gap solutions of the KdV equation can be generated by its recursion operator. We generalize the result to a special form of Lax pair, from which a method to constrain the integrable system to a lower-dimensional or fewer variable integrable system is proposed. A direct result is that the n-soliton solutions of the KdV hierarchy can be completely depicted by a series of ordinary differential equations (ODEs), which may be gotten by a simple but unfamiliar Lax pair. Furthermore the AKNS hierarchy is constrained to a series of univariate integrable hierarchies. The key is a special form of Lax pair for the AKNS hierarchy. It is proved that under the constraints all equations of the AKNS hierarchy are linearizable. (general)
PINGU sensitivity to neutrino mass hierarchy
International Nuclear Information System (INIS)
Groß, Andreas
2014-01-01
Determination of the neutrino mass hierarchy (NMH) is among the most fundamental questions in particle physics. Recent measurements of 1) a large mixing angle between the first and the third neutrino mass eigenstates and 2) the first observation of atmospheric neutrino oscillations at tens of GeV with neutrino telescopes, open the intriguing new possibility to exploit matter effects in neutrino oscillation to determine the neutrino mass hierarchy. A further extension of IceCube/DeepCore called PINGU (Precision IceCube Next Generation Upgrade) has been recently envisioned with the ultimate goal to measure neutrino mass hierarchy. PINGU would consist of additional IceCube-like strings of detectors deployed in the deepest and cleanest ice in the center of IceCube. More densely deployed instrumentation would provide a threshold substantially below 10 GeV and enhance the sensitivity to the mass hierarchy signal in atmospheric neutrinos. Here we discuss an estimate of the PINGU sensitivity to the mass hierarchy determined using an approximation with an Asimov dataset and an oscillation parameter fit
Boltzmann hierarchy for interacting neutrinos I: formalism
International Nuclear Information System (INIS)
Oldengott, Isabel M.; Rampf, Cornelius; Wong, Yvonne Y.Y.
2015-01-01
Starting from the collisional Boltzmann equation, we derive for the first time and from first principles the Boltzmann hierarchy for neutrinos including interactions with a scalar particle. Such interactions appear, for example, in majoron-like models of neutrino mass generation. We study two limits of the scalar mass: (i) An extremely massive scalar whose only role is to mediate an effective 4-fermion neutrino-neutrino interaction, and (ii) a massless scalar that can be produced in abundance and thus demands its own Boltzmann hierarchy. In contrast to, e.g., the first-order Boltzmann hierarchy for Thomson-scattering photons, our interacting neutrino/scalar Boltzmann hierarchies contain additional momentum-dependent collision terms arising from a non-negligible energy transfer in the neutrino-neutrino and neutrino-scalar interactions. This necessitates that we track each momentum mode of the phase space distributions individually, even if the particles were massless. Comparing our hierarchy with the commonly used (c eff 2 ,c vis 2 )-parameterisation, we find no formal correspondence between the two approaches, which raises the question of whether the latter parameterisation even has an interpretation in terms of particle scattering. Lastly, although we have invoked majoron-like models as a motivation for our study, our treatment is in fact generally applicable to all scenarios in which the neutrino and/or other ultrarelativistic fermions interact with scalar particles
Hierarchy and social status in Budongo chimpanzees.
Newton-Fisher, Nicholas E
2004-04-01
The status hierarchy is fundamental in the lives of male chimpanzees. This study describes the dominance interactions and social status among adult male chimpanzees of the Sonso community in the Budongo Forest Reserve, Uganda, during the period that they were first studied (1994 and 1995). Social dominance is typically measured using the behaviour of either the subordinate or the dominant individual, but a relationship is dependent on the behaviour of both parties and this study explicitly used both subordinate and dominant behaviours to investigate the status hierarchy. Among adult males of the Sonso community, agonistic interactions occurred at a low rate and pant-grunts were rare, but males could be ranked into separate hierarchies of agonistic dominance and pant-grunting (labelled 'respect') using ratios of behaviour performed/behaviour received. These hierarchies were combined to form a single hierarchy of social status that divided the males among five distinct status levels. The highest status level was held by an alliance between two males who replaced the previous alpha male during the first part of the study. Neither male in this alliance partnership pant-grunted to the other, although the reason for cooperative behaviour was unclear. Although the nominally beta male was treated as such by other adult males, he achieved surprisingly little mating success. Budongo Forest chimpanzees do not warrant the sometimes-expressed view that they are non-aggressive and peaceable and the broad pattern of their status interactions matches with that seen in other chimpanzee populations.
A generative model for scientific concept hierarchies.
Datta, Srayan; Adar, Eytan
2018-01-01
In many scientific disciplines, each new 'product' of research (method, finding, artifact, etc.) is often built upon previous findings-leading to extension and branching of scientific concepts over time. We aim to understand the evolution of scientific concepts by placing them in phylogenetic hierarchies where scientific keyphrases from a large, longitudinal academic corpora are used as a proxy of scientific concepts. These hierarchies exhibit various important properties, including power-law degree distribution, power-law component size distribution, existence of a giant component and less probability of extending an older concept. We present a generative model based on preferential attachment to simulate the graphical and temporal properties of these hierarchies which helps us understand the underlying process behind scientific concept evolution and may be useful in simulating and predicting scientific evolution.
Cohesion and Hierarchy in Physically Abusive Families
Directory of Open Access Journals (Sweden)
Clarissa De Antoni
2009-06-01
Full Text Available This paper investigates cohesion (emotional bonding and hierarchy (powerstructure in families with abuse against their children. Twenty low-incomefamilies participated. Father, mother and child’s perspective of family relations(cohesion and hierarchy were evaluated by the Family System Test(FAST. The relationship between father-child, mother-child, couple, andamong siblings were evaluated at typical and conflictive situations. Resultsshow a significance regarding to cohesion in typical and conflictive situationfor father-child and mother-child dyads in all perspectives (by father, mother,and child. There is no significant differences regarding to hierarchy. Theseresults suggest that the families see the intrafamilial violence as a constant,since they cannot differentiate between both situations.
A Global Mitigation Hierarchy for Nature Conservation
Bull, Joseph W; Addison, Prue F E; Burgass, Michael J; Gianuca, Dimas; Gorham, Taylor M; Jacob, Céline; Watson, James E M; Wilcox, Chris; Milner-Gulland, E J
2018-01-01
Abstract Efforts to conserve biodiversity comprise a patchwork of international goals, national-level plans, and local interventions that, overall, are failing. We discuss the potential utility of applying the mitigation hierarchy, widely used during economic development activities, to all negative human impacts on biodiversity. Evaluating all biodiversity losses and gains through the mitigation hierarchy could help prioritize consideration of conservation goals and drive the empirical evaluation of conservation investments through the explicit consideration of counterfactual trends and ecosystem dynamics across scales. We explore the challenges in using this framework to achieve global conservation goals, including operationalization and monitoring and compliance, and we discuss solutions and research priorities. The mitigation hierarchy's conceptual power and ability to clarify thinking could provide the step change needed to integrate the multiple elements of conservation goals and interventions in order to achieve successful biodiversity outcomes. PMID:29731513
Formal language theory: refining the Chomsky hierarchy
Jäger, Gerhard; Rogers, James
2012-01-01
The first part of this article gives a brief overview of the four levels of the Chomsky hierarchy, with a special emphasis on context-free and regular languages. It then recapitulates the arguments why neither regular nor context-free grammar is sufficiently expressive to capture all phenomena in the natural language syntax. In the second part, two refinements of the Chomsky hierarchy are reviewed, which are both relevant to the extant research in cognitive science: the mildly context-sensitive languages (which are located between context-free and context-sensitive languages), and the sub-regular hierarchy (which distinguishes several levels of complexity within the class of regular languages). PMID:22688632
A generative model for scientific concept hierarchies
Adar, Eytan
2018-01-01
In many scientific disciplines, each new ‘product’ of research (method, finding, artifact, etc.) is often built upon previous findings–leading to extension and branching of scientific concepts over time. We aim to understand the evolution of scientific concepts by placing them in phylogenetic hierarchies where scientific keyphrases from a large, longitudinal academic corpora are used as a proxy of scientific concepts. These hierarchies exhibit various important properties, including power-law degree distribution, power-law component size distribution, existence of a giant component and less probability of extending an older concept. We present a generative model based on preferential attachment to simulate the graphical and temporal properties of these hierarchies which helps us understand the underlying process behind scientific concept evolution and may be useful in simulating and predicting scientific evolution. PMID:29474409
On self-dual Yang-Mills hierarchy
International Nuclear Information System (INIS)
Nakamura, Yoshimasa
1989-01-01
In this note, motivated by the Kadomtsev-Petviashvili (KP) hierarchy of integrable nonlinear evolution equations, a GL(n,C) self-dual Yang-Mills (SDYM) hierarchy is presented; it is an infinite system of SDYM equations having an infinite number of independent variables and being outside of the KP hierarchy. A relationship between the KP hierarchy and the SDYM hierarchy is discussed. It is also shown that GL(∞) SDYM equations introduced in this note are reduced to the GL(n,C) SDYM hierarchy by imposing an algebraic constraint. (orig.)
An Operational Investigation of the CPS Hierarchy
DEFF Research Database (Denmark)
Danvy, Olivier; Yang, Zhe
1999-01-01
We explore the hierarchy of control induced by successive transformations into continuation-passing style (CPS) in the presence of “control delimiters ” and “composable continuations ”. Specifically, we investigate the structural operational semantics associated with the CPS hierarchy. To this end......, we characterize an operational notion of continuation semantics. We relate it to the traditional CPS transformation and we use it to account for the control operator shift and the control delimiter reset operationally. We then transcribe the resulting continuation semantics in ML, thus obtaining...
An Operational Investigation of the CPS Hierarchy
DEFF Research Database (Denmark)
Danvy, Olivier; Yang, Zhe
1998-01-01
We explore the hierarchy of control induced by successive transformations into continuation-passing style (CPS) in the presence of “control delimiters ” and “composable continuations ”. Specifically, we investigate the structural operational semantics associated with the CPS hierarchy. To this end......, we characterize an operational notion of continuation semantics. We relate it to the traditional CPS transformation and we use it to account for the control operator shift and the control delimiter reset operationally. We then transcribe the resulting continuation semantics in ML, thus obtaining...
Contrastive hierarchies, privative features, and Portuguese vowels
Directory of Open Access Journals (Sweden)
Joaquim Brandão de Carvalho
2011-01-01
Full Text Available Dresher’s (2009 Contrastive hierarchy theory (CHT is intended to provide a unified account of both sides of phonological primes: contrastivity and behaviour. This article explores the point and the possibility of extending CHT, which is based on binary features, to a system of monovalent elements that is much indebted to Schane’s (1984 Particle Phonology. It shows how several aspects of the phonology of European Portuguese nuclei that seem prima facie independent from one another – such as reduction patterns and the inventory of diphthongs and nasal vowels – are constrained by element hierarchy, and, thus, receive a unitary account.
MOS modeling hierarchy including radiation effects
International Nuclear Information System (INIS)
Alexander, D.R.; Turfler, R.M.
1975-01-01
A hierarchy of modeling procedures has been developed for MOS transistors, circuit blocks, and integrated circuits which include the effects of total dose radiation and photocurrent response. The models were developed for use with the SCEPTRE circuit analysis program, but the techniques are suitable for other modern computer aided analysis programs. The modeling hierarchy permits the designer or analyst to select the level of modeling complexity consistent with circuit size, parametric information, and accuracy requirements. Improvements have been made in the implementation of important second order effects in the transistor MOS model, in the definition of MOS building block models, and in the development of composite terminal models for MOS integrated circuits
Program information architecture/document hierarchy
International Nuclear Information System (INIS)
Woods, T.W.
1991-09-01
The Nuclear Waste Management System (NWMS) Management Systems Improvement Strategy (MSIS) (DOE 1990) requires that the information within the computer program and information management system be ordered into a precedence hierarchy for consistency. Therefore, the US Department of Energy (DOE). Office of Civilian Radioactive Waste Management (OCRWM) requested Westinghouse Hanford Company to develop a plan for NWMS program information which the MSIS calls a document hierarchy. This report provides the results of that effort and describes the management system as a ''program information architecture.'' 3 refs., 3 figs
Do experiments suggest a hierarchy problem?
International Nuclear Information System (INIS)
Vissani, F.
1997-09-01
The hierarchy problem of the scalar sector of the standard model is reformulated, emphasizing the role of experimental facts that may suggest the existence of a new physics large mass scale, for instance indications of the instability of the matter, or indications in favor of massive neutrinos. In the see-saw model for the neutrino masses a hierarchy problem arises if the mass of the right-handed neutrinos is larger than approximatively 10 7 GeV: this problem, and its possible solutions, are discussed. (author)
A simplified BBGKY hierarchy for correlated fermions from a stochastic mean-field approach
International Nuclear Information System (INIS)
Lacroix, Denis; Tanimura, Yusuke; Ayik, Sakir; Yilmaz, Bulent
2016-01-01
The stochastic mean-field (SMF) approach allows to treat correlations beyond mean-field using a set of independent mean-field trajectories with appropriate choice of fluctuating initial conditions. We show here that this approach is equivalent to a simplified version of the Bogolyubov-Born-Green-Kirkwood-Yvon (BBGKY) hierarchy between one-, two-,.., N -body degrees of freedom. In this simplified version, one-body degrees of freedom are coupled to fluctuations to all orders while retaining only specific terms of the general BBGKY hierarchy. The use of the simplified BBGKY is illustrated with the Lipkin-Meshkov-Glick (LMG) model. We show that a truncated version of this hierarchy can be useful, as an alternative to the SMF, especially in the weak coupling regime to get physical insight in the effect beyond mean-field. In particular, it leads to approximate analytical expressions for the quantum fluctuations both in the weak and strong coupling regime. In the strong coupling regime, it can only be used for short time evolution. In that case, it gives information on the evolution time-scale close to a saddle point associated to a quantum phase-transition. For long time evolution and strong coupling, we observed that the simplified BBGKY hierarchy cannot be truncated and only the full SMF with initial sampling leads to reasonable results. (orig.)
Directory of Open Access Journals (Sweden)
Encheng Sun
Full Text Available West Nile virus (WNV is a mosquito-borne flavivirus that primarily infects birds but occasionally infects humans and horses. Certain species of birds, including crows, house sparrows, geese, blue jays and ravens, are considered highly susceptible hosts to WNV. The nonstructural protein 1 (NS1 of WNV can elicit protective immune responses, including NS1-reactive antibodies, during infection of animals. The antigenicity of NS1 suggests that NS1-reactive antibodies could provide a basis for serological diagnostic reagents. To further define serological reagents for diagnostic use, the antigenic sites in NS1 that are targeted by host immune responses need to be identified and the potential diagnostic value of individual antigenic sites also needs to be defined. The present study describes comprehensive mapping of common immunodominant linear B-cell epitopes in the WNV NS1 using avian WNV NS1 antisera. We screened antisera from chickens, ducks and geese immunized with purified NS1 for reactivity against 35 partially overlapping peptides covering the entire WNV NS1. This study identified twelve, nine and six peptide epitopes recognized by chicken, duck and goose antibody responses, respectively. Three epitopes (NS1-3, 14 and 24 were recognized by antibodies elicited by immunization in all three avian species tested. We also found that NS1-3 and 24 were WNV-specific epitopes, whereas the NS1-14 epitope was conserved among the Japanese encephalitis virus (JEV serocomplex viruses based on the reactivity of avian WNV NS1 antisera against polypeptides derived from the NS1 sequences of viruses of the JEV serocomplex. Further analysis showed that the three common polypeptide epitopes were not recognized by antibodies in Avian Influenza Virus (AIV, Newcastle Disease Virus (NDV, Duck Plague Virus (DPV and Goose Parvovirus (GPV antisera. The knowledge and reagents generated in this study have potential applications in differential diagnostic approaches and
Directory of Open Access Journals (Sweden)
Gema Álvarez García
2006-08-01
Full Text Available A Neospora caninum 17 kDa protein fraction (p17 has been described as an immunodominant antigen (IDA under reducing and non-reducing conditions. The aim of the present study was to investigate the diagnostic utility of p17 in cattle. In order to achieve this, p17 was purified by electroelution from whole N. caninum tachyzoite soluble extract and a p17-based Western blot (WB-p17 was developed. The p17 recognition was measured by densitometry and expressed as OD values to check the validity of the WB-p17. A total of 131 sera including sequential samples from naturally- and experimentally-infected calves and breeding cattle were analysed by WB-p17 and compared with IFAT using whole formalin-fixed tachyzoites as a reference test. The results obtained highlight the feasibility of using the N. caninum p17 in a diagnostic test in cattle. Firstly, the assay based on the p-17 antigen discriminated between known positive and negative sera from different cattle populations, breeding cattle and calves. Secondly, the p17 antigen detected fluctuations in the antibody levels and seroconversion in naturally- and experimentally-infected cattle. Significant differences in p-17 antigen recognition were observed between naturally infected aborting and non-aborting cattle, as well as significant antibody fluctuations over time in experimentally infected cattle, which varied between groups. Furthermore, the results obtained with WB-p17 are in accordance with the results obtained with the IFAT, as high agreement values were obtained when all bovine subpopulations were included (kappa = 0.86.
Mattioli, S; Imberti, L; Stellini, R; Primi, D
1995-09-01
Hepatitis A virus (HAV) is a positive-strand RNA virus with a genome length of approximately 7,480 nucleotides. Although HAV morphogenesis is thought to be similar to that of poliovirus, the prototype picornavirus, the complete characterization of the antigenic structure of this virus remains elusive. All the available evidences, however, support the existence, on HAV virions and empty capsids, of an immunodominant neutralization antigenic site which is conformation dependent and whose structure involves residues of both VP1 and VP3 capsid proteins. This particular feature and the difficulty of obtaining high virus yield in tissue cultures make HAV an ideal target for developing synthetic peptides that simulate the structure of its main antigenic determinant. To this end we utilized, in the present work, the divide-couple-recombine approach to generate a random library composed of millions of different hexapeptides. This vast library was screened with a well-characterized anti-HAV monoclonal antibody. By this strategy we identified a peptide that reacted specifically with monoclonal and polyclonal anti-HAV antibodies and, in mice, induced a specific anti-virus immune response. Furthermore, the peptide could also be used in an enzyme-linked immunosorbent assay for revealing a primary immunoglobulin M immune response in sera of acutely infected human patients. Interestingly, no sequence homology was found between the identified peptide and the HAV capsid proteins VP1 and VP3. Collectively, these data represent an additional important paradigm of a mimotope capable of mimicking an antigenic determinant with unknown tertiary structure.
A hierarchy of distress and invariant item ordering in the General Health Questionnaire-12.
Doyle, F; Watson, R; Morgan, K; McBride, O
2012-06-01
Invariant item ordering (IIO) is defined as the extent to which items have the same ordering (in terms of item difficulty/severity - i.e. demonstrating whether items are difficult [rare] or less difficult [common]) for each respondent who completes a scale. IIO is therefore crucial for establishing a scale hierarchy that is replicable across samples, but no research has demonstrated IIO in scales of psychological distress. We aimed to determine if a hierarchy of distress with IIO exists in a large general population sample who completed a scale measuring distress. Data from 4107 participants who completed the 12-item General Health Questionnaire (GHQ-12) from the Northern Ireland Health and Social Wellbeing Survey 2005-6 were analysed. Mokken scaling was used to determine the dimensionality and hierarchy of the GHQ-12, and items were investigated for IIO. All items of the GHQ-12 formed a single, strong unidimensional scale (H=0.58). IIO was found for six of the 12 items (H-trans=0.55), and these symptoms reflected the following hierarchy: anhedonia, concentration, participation, coping, decision-making and worthlessness. The cross-sectional analysis needs replication. The GHQ-12 showed a hierarchy of distress, but IIO is only demonstrated for six of the items, and the scale could therefore be shortened. Adopting brief, hierarchical scales with IIO may be beneficial in both clinical and research contexts. Copyright © 2011 Elsevier B.V. All rights reserved.
Fuzzy Logic and Arithmetical Hierarchy III
Czech Academy of Sciences Publication Activity Database
Hájek, Petr
2001-01-01
Roč. 68, č. 1 (2001), s. 129-142 ISSN 0039-3215 R&D Projects: GA AV ČR IAA1030004 Institutional research plan: AV0Z1030915 Keywords : fuzzy logic * basic fuzzy logic * Lukasiewicz logic * Godel logic * product logic * arithmetical hierarchy Subject RIV: BA - General Mathematics
Large hierarchies from approximate R symmetries
International Nuclear Information System (INIS)
Kappl, Rolf; Ratz, Michael; Vaudrevange, Patrick K.S.
2008-12-01
We show that hierarchically small vacuum expectation values of the superpotential in supersymmetric theories can be a consequence of an approximate R symmetry. We briefly discuss the role of such small constants in moduli stabilization and understanding the huge hierarchy between the Planck and electroweak scales. (orig.)
The hamiltonian structures of the KP hierarchy
International Nuclear Information System (INIS)
Das, A.; Panda, S.; Huang Wenjui
1991-01-01
We obtain the two hamiltonian structures of the KP hierarchy following the method of Drinfeld and Sokolov. We point out how the second structure of Drinfeld and Sokolov needs to be modified in the present case. We briefly comment on the connection between these structures and the W 1+∞ algebra. (orig.)
A note on the substructural hierarchy
Czech Academy of Sciences Publication Activity Database
Jeřábek, Emil
2016-01-01
Roč. 62, 1-2 (2016), s. 102-110 ISSN 0942-5616 EU Projects: European Commission(XE) 339691 - FEALORA Institutional support: RVO:67985840 Keywords : substructural hierarchy * full Lambek calculus * extension variables Subject RIV: BA - General Mathematics Impact factor: 0.250, year: 2016 http://dx.doi.org/10.1002/malq.201500066
Signaling hierarchy regulating human endothelial cell development
Our present knowledge of the regulation of mammalian endothelial cell differentiation has been largely derived from studies of mouse embryonic development. However, unique mechanisms and hierarchy of signals that govern human endothelial cell development are unknown and, thus, explored in these stud...
The Analytic Hierarchy Process and Participatory Decisionmaking
Daniel L. Schmoldt; Daniel L. Peterson; Robert L. Smith
1995-01-01
Managing natural resource lands requires social, as well as biophysical, considerations. Unfortunately, it is extremely difficult to accurately assess and quantify changing social preferences, and to aggregate conflicting opinions held by diverse social groups. The Analytic Hierarchy Process (AHP) provides a systematic, explicit, rigorous, and robust mechanism for...
Using Analytic Hierarchy Process in Textbook Evaluation
Kato, Shigeo
2014-01-01
This study demonstrates the application of the analytic hierarchy process (AHP) in English language teaching materials evaluation, focusing in particular on its potential for systematically integrating different components of evaluation criteria in a variety of teaching contexts. AHP is a measurement procedure wherein pairwise comparisons are made…
The Hamiltonian structures of the KP hierarchy
International Nuclear Information System (INIS)
Das, A.; Panda, S.; Huang Wenjui
1991-08-01
We obtain the two Hamiltonian structures of the KP hierarchy following the method of Drinfeld and Sokolov. We point out how the second structure of Drinfeld and Sokolov needs to be modified in the present case. We briefly comment on the connection between these structures and the W 1+∞ algebra. (author). 18 refs
A hierarchy of systems of nonlinear equations
International Nuclear Information System (INIS)
Falkensteiner, P.; Grosse, H.
1985-01-01
Imposing isospectral invariance for the one-dimensional Dirac operator yields an infinite hierarchy of systems of chiral invariant nonlinear partial differential equations. The same system is obtained through a Lax pair construction and finally a formulation in terms of Kac-Moody generators is given. (Author)
Prioritization of Programmer's Productivity Using Analytic Hierarchy ...
African Journals Online (AJOL)
This paper focuses on the application of Analytic Hierarchy Process (AHP) model in the context of prioritizing programmer's productivity in University of Benin, Benin City Nigeria. This is achieved by evaluating the way in which the AHP model can be used to select the best programmer for the purpose of developing software ...
Dark energy and the hierarchy problem
International Nuclear Information System (INIS)
Chen, Pisin
2007-01-01
The well-known hierarchy between the Planck scale (∼10 19 GeV) and the TeV scale, namely a ratio of ∼10 16 between the two, is coincidentally repeated in a inverted order between the TeV scale and the dark energy scale at ∼10 -3 eV implied by the observations. We argue that this is not a numerical coincidence. The same brane-world setups to address the first hierarchy problem may also in principle address this second hierarchy issue. Specifically, we consider supersymmetry in the bulk and its breaking on the brane and resort to the Casimir energy induced by the bulk graviton-gravitino mass-shift on the brane as the dark energy. For the ADD model we found that our notion is sensible only if the number of extra dimension n=2. We extend our study to the Randall-Sundrum model. Invoking the chirality-flip on the boundaries for SUSY-breaking, the zero-mode gravitino contribution to the Casimir energy does give rise to the double hierarchy. Unfortunately since the higher Kaluza-Klein modes acquire relative mass-shifts at the TeV level, the zero-mode contribution to Casimir energy is overshadowed
Classification hierarchies for product data modelling
Pels, H.J.
2006-01-01
Abstraction is an essential element in data modelling that appears mainly in one of the following forms: generalisation, classification or aggregation. In the design of complex products classification hierarchies can be found product families that are viewed as classes of product types, while
Stress amplifies memory for social hierarchy.
Cordero, María Isabel; Sandi, Carmen
2007-11-01
Individuals differ in their social status and societies in the extent of social status differences among their members. There is great interest in understanding the key factors that contribute to the establishment of social dominance structures. Given that stress can affect behavior and cognition, we hypothesized that, given equal opportunities to become either dominant or submissive, stress experienced by one of the individuals during their first encounter would determine the long-term establishment of a social hierarchy by acting as a two-stage rocket: (1) by influencing the rank achieved after a social encounter and (2) by facilitating and/or promoting a long-term memory for the specific hierarchy. Using a novel model for the assessment of long-term dominance hierarchies in rats, we present here the first evidence supporting such hypothesis. In control conditions, the social rank established through a first interaction and food competition test between two male rats is not maintained when animals are confronted 1 week later. However, if one of the rats is stressed just before their first encounter, the dominance hierarchy developed on day 1 is still clearly observed 1 week later, with the stressed animal becoming submissive (i.e., looser in competition tests) in both social interactions. Our findings also allow us to propose that stress potentiates a hierarchy-linked recognition memory between "specific" individuals through mechanisms that involve de novo protein synthesis. These results implicate stress among the key mechanisms contributing to create social imbalance and highlight memory mechanisms as key mediators of stress-induced long-term establishment of social rank.
Stress amplifies memory for social hierarchy
Directory of Open Access Journals (Sweden)
María I Cordero
2007-10-01
Full Text Available Individuals differ in their social status and societies in the extent of social status differences among their members. There is great interest in understanding the key factors that contribute to the establishment of social dominance structures. Given that stress can affect behavior and cognition, we hypothesized that, given equal opportunities to become either dominant or submissive, stress experienced by one of the individuals during their first encounter would determine the long-term establishment of a social hierarchy by acting as a two-stage rocket: (1 by influencing the rank achieved after a social encounter and (2 by facilitating and/or promoting a long-term memory for the specific hierarchy. Using a novel model for the assessment of long-term dominance hierarchies in rats, we present here the first evidence supporting such hypothesis. In control conditions, the social rank established through a first interaction and food competition test between two male rats is not maintained when animals are confronted 1 week later. However, if one of the rats is stressed just before their first encounter, the dominance hierarchy developed on day 1 is still clearly observed 1 week later, with the stressed animal becoming submissive (i.e., looser in competition tests in both social interactions. Our findings also allow us to propose that stress potentiates a hierarchy-linked recognition memory between “specific” individuals through mechanisms that involve de novo protein synthesis. These results implicate stress among the key mechanisms contributing to create social imbalance and highlight memory mechanisms as key mediators of stress-induced long-term establishment of social rank.
The Helmholtz Hierarchy: Phase Space Statistics of Cold Dark Matter
Tassev, Svetlin
2010-01-01
We present a new formalism to study large-scale structure in the universe. The result is a hierarchy (which we call the "Helmholtz Hierarchy") of equations describing the phase space statistics of cold dark matter (CDM). The hierarchy features a physical ordering parameter which interpolates between the Zel'dovich approximation and fully-fledged gravitational interactions. The results incorporate the effects of stream crossing. We show that the Helmholtz hierarchy is self-consistent and obeys...
Special polynomials associated with rational solutions of some hierarchies
International Nuclear Information System (INIS)
Kudryashov, Nikolai A.
2009-01-01
New special polynomials associated with rational solutions of the Painleve hierarchies are introduced. The Hirota relations for these special polynomials are found. Differential-difference hierarchies to find special polynomials are presented. These formulae allow us to search special polynomials associated with the hierarchies. It is shown that rational solutions of the Caudrey-Dodd-Gibbon, the Kaup-Kupershmidt and the modified hierarchy for these ones can be obtained using new special polynomials.
Method and System for Making OLAP Hierarchies Summarisable
DEFF Research Database (Denmark)
2002-01-01
Field of Invention: The present invention relates to computer databases, in particular to a method and system for transforming general OLAP hierarchies into summarizable hierarchies. This enables fast query response times for aggregation queries without excessive storage use even when the hierarc......Field of Invention: The present invention relates to computer databases, in particular to a method and system for transforming general OLAP hierarchies into summarizable hierarchies. This enables fast query response times for aggregation queries without excessive storage use even when...
Becker, María Inés; Fuentes, Alejandra; Del Campo, Miguel; Manubens, Augusto; Nova, Esteban; Oliva, Harold; Faunes, Fernando; Valenzuela, María Antonieta; Campos-Vallette, Marcelo; Aliaga, Alvaro; Ferreira, Jorge; De Ioannes, Alfredo E; De Ioannes, Pablo; Moltedo, Bruno
2009-03-01
Hemocyanin, the oxygen transporter metallo-glycoprotein from mollusks, shows strong relationship between its notable structural features and intrinsic immunomodulatory effects. Here we investigated the individual contribution of CCHA and CCHB subunits from Concholepas hemocyanin (CCH) to in vivo humoral immune response and their pre-clinical evaluation as immunotherapeutic agent in a mice bladder cancer model, in relation to their biochemical properties. To this end, subunits were purified and well characterized. Homogeneous subunits were obtained by anionic exchange chromatography, and its purity assessed by electrophoretic and immunochemical methods. While each CCH subunit contains eight functional units showing partial cross reaction, the vibrational spectral analysis showed several spectral differences, suggesting structural differences between them. In addition, we demonstrated differences in the carbohydrate content: CCHA had a 3.6% w/w sugar with both N- and O-linked moieties. In turn, CCHB had a 2.5% w/w sugar with N-linked, while O-linked moieties were nearly absent. Considering these differences, it was not possible to predict a priori whether the immunogenic and immunotherapeutic properties of subunits might be similar. Surprisingly, both subunits by itself induced a humoral response, and showed an antitumor effect in the bladder carcinoma cell line MBT-2. However, when immunologic parameters were analyzed, CCHA showed better efficiency than CCHB. No allergic reactions or any toxic effects were observed in mice treated with CCHA, sustaining its potential therapeutic use. Our study supports that CCHA subunit accounts for the most important features involved in the immunogenicity of CCH, such as better hydrophilicity and higher content of carbohydrates.
Maslow and the motivation hierarchy: measuring satisfaction of the needs.
Taormina, Robert J; Gao, Jennifer H
2013-01-01
For each of the 5 needs in Maslow's motivational hierarchy (physiological, safety-security, belongingness, esteem, and self-actualization), operational definitions were developed from Maslow's theory of motivation. New measures were created based on the operational definitions (1) to assess the satisfaction of each need, (2) to assess their expected correlations (a) with each of the other needs and (b) with four social and personality measures (i.e., family support, traditional values, anxiety/worry, and life satisfaction), and (3) to test the ability of the satisfaction level of each need to statistically predict the satisfaction level of the next higher-level need. Psychometric tests of the scales conducted on questionnaire results from 386 adult respondents from the general population lent strong support for the validity and reliability of all 5 needs measures. Significant positive correlations among the scales were also found; that is, the more each lower-level need was satisfied, the more the next higher-level need was satisfied. Additionally, as predicted, family support, traditional values, and life satisfaction had significant positive correlations with the satisfaction of all 5 needs, and the anxiety/worry facet of neuroticism had significant negative correlations with the satisfaction of all the needs. Multiple regression analyses revealed that the satisfaction of each higher-level need was statistically predicted by the satisfaction of the need immediately below it in the hierarchy, as expected from Maslow's theory.
Quark-lepton complementarity relation and neutrino mass hierarchy
International Nuclear Information System (INIS)
Ferrandis, Javier; Pakvasa, Sandip
2005-01-01
Latest measurements have revealed that the deviation from a maximal solar mixing angle is approximately the Cabibbo angle [i.e., quark-lepton complementarity (QLC) relation]. We argue that it is not plausible that this deviation from maximality, be it a coincidence or not, comes from the charged lepton mixing. Consequently we have calculated the required corrections to the exactly bimaximal neutrino mass matrix ansatz necessary to account for the solar mass difference and the solar mixing angle. We point out that the relative size of these two corrections depends strongly on the hierarchy case under consideration. We find that the inverted hierarchy case with opposite CP parities, which is known to guarantee the renormalization group equations stability of the solar mixing angle, offers the most plausible scenario for a high-energy origin of a QLC-corrected bimaximal neutrino mass matrix. This possibility may allow us to explain the QLC relation in connection with the origin of the charged fermion mass matrices
DEFF Research Database (Denmark)
Brix, Thomas Heiberg; Hegedüs, Laszlo; Gardas, Andrzej
2011-01-01
Thyroid peroxidase antibodies (TPOAbs) in patients with Hashimoto's thyroiditis (HT) predominantly react with two immunodominant regions (IDR-A, IDR-B). Theoretically, as shown for the level of TPOAbs, the autoantibody epitopic recognition of the IDRs could be under genetic control. To examine this......, we compared the distribution of TPOAb epitopic fingerprints between healthy monozygotic (MZ) co-twins and siblings to patients with clinically overt HT with a control group of euthyroid subjects, matched for sex and age, but without autoimmune thyroid disease (AITD) among their first-degree relatives...
DEFF Research Database (Denmark)
Que, Xuchu; Widhopf Ii, George F; Amir, Shahzada
2013-01-01
The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV1-69 is the most common, and often is expressed...... are products of enhanced lipid peroxidation and a major target of innate natural antibodies. Specifically, CLL69C bound immunodominant OSE adducts termed MAA (malondialdehyde-acetaldehyde-adducts), which are found on apoptotic cells, inflammatory tissues, and atherosclerotic lesions. It also reacted...
Operator approach to solutions of the constrained BKP hierarchy
International Nuclear Information System (INIS)
Shen, Hsin-Fu; Lee, Niann-Chern; Tu, Ming-Hsien
2011-01-01
The operator formalism to the vector k-constrained BKP hierarchy is presented. We solve the Hirota bilinear equations of the vector k-constrained BKP hierarchy via the method of neutral free fermion. In particular, by choosing suitable group element of O(∞), we construct rational and soliton solutions of the vector k-constrained BKP hierarchy.
Functional calculus in strong plasma turbulence
International Nuclear Information System (INIS)
Ahmadi, G.; Hirose, A.
1980-01-01
The theory of electrostatic plasma turbulence is considered. The basic equations for the dynamics of the hierarchy of the moment equations are derived and the difficulty of the closure problem for strong plasma turbulence is discussed. The characteristic functional in phase space is introduced and its relations to the correlation functions are described. The Hopf functional equation for dynamics of the characteristic functional is derived, and its equivalence to the hierarchy of the moment equations is established. Similar formulations were carried out in velocity-wave vector space. The cross-spectral moments and the characteristic functional are considered and their relationships are studied. An approximate solution for Hopf's equation for the nearly normal turbulence is obtained which is shown to predict diffusion of the mean distribution function in velocity space. (author)
The Helmholtz Hierarchy: phase space statistics of cold dark matter
International Nuclear Information System (INIS)
Tassev, Svetlin V.
2011-01-01
We present a new formalism to study large-scale structure in the universe. The result is a hierarchy (which we call the ''Helmholtz Hierarchy'') of equations describing the phase space statistics of cold dark matter (CDM). The hierarchy features a physical ordering parameter which interpolates between the Zel'dovich approximation and fully-fledged gravitational interactions. The results incorporate the effects of stream crossing. We show that the Helmholtz hierarchy is self-consistent and obeys causality to all orders. We present an interpretation of the hierarchy in terms of effective particle trajectories
The multicomponent 2D Toda hierarchy: dispersionless limit
International Nuclear Information System (INIS)
Mañas, Manuel; Alonso, Luis Martínez
2009-01-01
The factorization problem of the multi-component 2D Toda hierarchy is used to analyze the dispersionless limit of this hierarchy. A dispersive version of the Whitham hierarchy defined in terms of scalar Lax and Orlov–Schulman operators is introduced and the corresponding additional symmetries and string equations are discussed. Then, it is shown how KP and Toda pictures of the dispersionless Whitham hierarchy emerge in the dispersionless limit. Moreover, the additional symmetries and string equations for the dispersive Whitham hierarchy are studied in this limit
Neural basis of social status hierarchy across species.
Chiao, Joan Y
2010-12-01
Social status hierarchy is a ubiquitous principle of social organization across the animal kingdom. Recent findings in social neuroscience reveal distinct neural networks associated with the recognition and experience of social hierarchy in humans, as well as modulation of these networks by personality and culture. Additionally, allelic variation in the serotonin transporter gene is associated with prevalence of social hierarchy across species and cultures, suggesting the importance of the study of genetic factors underlying social hierarchy. Future studies are needed to determine how genetic and environmental factors shape neural systems involved in the production and maintenance of social hierarchy across ontogeny and phylogeny. Copyright Â© 2010 Elsevier Ltd. All rights reserved.
Nanostructural hierarchy increases the strength of aluminium alloys.
Liddicoat, Peter V; Liao, Xiao-Zhou; Zhao, Yonghao; Zhu, Yuntian; Murashkin, Maxim Y; Lavernia, Enrique J; Valiev, Ruslan Z; Ringer, Simon P
2010-09-07
Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075 alloy exhibits a yield strength and uniform elongation approaching 1 GPa and 5%, respectively. The nanostructural architecture was observed using novel high-resolution microscopy techniques and comprises a solid solution, free of precipitation, featuring (i) a high density of dislocations, (ii) subnanometre intragranular solute clusters, (iii) two geometries of nanometre-scale intergranular solute structures and (iv) grain sizes tens of nanometres in diameter. Our results demonstrate that this novel architecture offers a design pathway towards a new generation of super-strong materials with new regimes of property-performance space.
Ways to remember disasters - inclusions, exclusions and hierarchies
DEFF Research Database (Denmark)
Andersen, Nina Blom
2009-01-01
citizens affected or hurt from spectacular events only get their situation acknowledged in a certain period after an event has occurred and why the rest of society loose interest after a while. There can be a number of reasons for this, but the influence of a hierarchy of grief and affectedness...... that this paper deals with. It will be argued, that there is a strong focus on the situation of citizens that suffers from, are affected or hurt by spectacular disasters. At least for a while after the event has taken place. The citizens get acknowledgement and eagerness to express care and support can...... are understood as a burden for individuals instead of a collective and social problem. Disasters are remembered as events that affected and hurt a number of people, not as events that collective societal actors can learn from and work to prevent in the future. The paper further deals with the discussion why...
An Imperative Type Hierarchy with Partial Products
DEFF Research Database (Denmark)
Schwartzbach, Michael Ignatieff; Schmidt, Erik Meineche
1989-01-01
notation for defining recursive types, that is superior to traditional type sums and products. We show how the ordering on types extends to an ordering on types with invariants. We allow the use of least upper bounds in type definitions and show how to compute upper bounds of invariants.......A type hierarchy for a programming language defines an ordering on the types such that any application for small types may be reused for all larger types. The imperative facet makes this non-trivial; the straight-forward definitions will yield an inconsistent system. We introduce a new type...... constructor, the partial product, and show how to define a consistent hierarchy in the context of fully recursive types. A simple polymorphism is derived by introducing a notion of placeholder types. By extending the partial product types to include structural invariants we obtain a particularly appropriate...
Feminist Praxis, Critical Theory and Informal Hierarchies
Directory of Open Access Journals (Sweden)
Eva Giraud
2015-05-01
Full Text Available This article draws on my experiences teaching across two undergraduate media modules in a UK research-intensive institution to explore tactics for combatting both institutional and informal hierarchies within university teaching contexts. Building on Sara Motta’s (2012 exploration of implementing critical pedagogic principles at postgraduate level in an elite university context, I discuss additional tactics for combatting these hierarchies in undergraduate settings, which were developed by transferring insights derived from informal workshops led by the University of Nottingham’s Feminism and Teaching network into the classroom. This discussion is framed in relation to the concepts of “cyborg pedagogies” and “political semiotics of articulation,” derived from the work of Donna Haraway, in order to theorize how these tactics can engender productive relationships between radical pedagogies and critical theory.
Scale hierarchy in high-temperature QCD
Akerlund, Oscar
2013-01-01
Because of asymptotic freedom, QCD becomes weakly interacting at high temperature: this is the reason for the transition to a deconfined phase in Yang-Mills theory at temperature $T_c$. At high temperature $T \\gg T_c$, the smallness of the running coupling $g$ induces a hierachy betwen the "hard", "soft" and "ultrasoft" energy scales $T$, $g T$ and $g^2 T$. This hierarchy allows for a very successful effective treatment where the "hard" and the "soft" modes are successively integrated out. However, it is not clear how high a temperature is necessary to achieve such a scale hierarchy. By numerical simulations, we show that the required temperatures are extremely high. Thus, the quantitative success of the effective theory down to temperatures of a few $T_c$ appears surprising a posteriori.
Generalized non-linear Schroedinger hierarchy
International Nuclear Information System (INIS)
Aratyn, H.; Gomes, J.F.; Zimerman, A.H.
1994-01-01
The importance in studying the completely integrable models have became evident in the last years due to the fact that those models present an algebraic structure extremely rich, providing the natural scenery for solitons description. Those models can be described through non-linear differential equations, pseudo-linear operators (Lax formulation), or a matrix formulation. The integrability implies in the existence of a conservation law associated to each of degree of freedom. Each conserved charge Q i can be associated to a Hamiltonian, defining a time evolution related to to a time t i through the Hamilton equation ∂A/∂t i =[A,Q i ]. Particularly, for a two-dimensions field theory, infinite degree of freedom exist, and consequently infinite conservation laws describing the time evolution in space of infinite times. The Hamilton equation defines a hierarchy of models which present a infinite set of conservation laws. This paper studies the generalized non-linear Schroedinger hierarchy
Inverted radiative hierarchy of quark masses
International Nuclear Information System (INIS)
Berezhiani, Z.G.; Rattazzi, R.
1992-01-01
Inverted radiative hierarchy of quark masses is investigated. The authors suggest that the mass hierarchy is first generated in a sector of heavy isosinglet fermions due to radiative effects and then projected in the inverted way to the usual quarks by means of a universal seesaw. The simple left-right symmetric gauge model is presented with the P- and CP-parities and the exact isotopical symmetry which are softly (or spontaneously) broken in the Higgs potential. This approach naturally explains the observed pattern of quark masses and mixing, providing the quantitatively correct formula for the Cabibbo angle. Top quark is predicted to be in the 90-150 GeV range
Directory of Open Access Journals (Sweden)
Rhea J Longley
Full Text Available Malaria, caused by the Plasmodium parasite, remains a serious global public health concern. A vaccine could have a substantial impact on eliminating this disease, alongside other preventative measures. We recently described the development of three novel, viral vectored vaccines expressing either of the antigens PfUIS3, PfLSA1 and PfLSAP2. Each vaccination regimen provided high levels of protection against chimeric parasite challenge in a mouse model, largely dependent on CD8+ T cells. In this study we aimed to further characterize the induced cellular immune response to these vaccines. We utilized both the IFNγ enzyme-linked immunosorbent spot assay and intracellular cytokine staining to achieve this aim. We identified immunodominant peptide responses for CD4+ and CD8+ T cells for each of the antigens in BALB/c, C57BL/6 and HLA-A2 transgenic mice, creating a useful tool for researchers for subsequent study of these antigens. We also compared these immunodominant peptides with those generated from epitope prediction software, and found that only a small proportion of the large number of epitopes predicted by the software were identifiable experimentally. Furthermore, we characterized the polyfunctionality of the induced CD8+ T cell responses. These findings contribute to our understanding of the immunological mechanisms underlying these protective vaccines, and provide a useful basis for the assessment of these and related vaccines as clinical constructs.
International Nuclear Information System (INIS)
Feng, Youjun; Qi, Jianxun; Zhang, Huimin; Wang, Jinzi; Liu, Jinhua; Jiang, Fan; Gao, Feng
2005-01-01
X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide. Simian immunodeficiency virus (SIV) in the rhesus macaque is regarded as a classic animal model, playing a crucial role in HIV vaccine strategies and therapeutics by characterizing various cytotoxic T-lymphocyte (CTL) responses in macaque monkeys. However, the availability of well documented structural reports focusing on rhesus macaque major histocompatibility complex class I (MHC I) molecules remains extremely limited. Here, a complex of the rhesus macaque MHC I molecule (Mamu-A*02) with human β 2 m and an immunodominant SIV-Gag nonapeptide, GESNLKSLY (GY9), has been crystallized. The crystal diffracts X-rays to 2.7 Å resolution and belongs to space group C2, with unit-cell parameters a = 124.11, b = 110.45, c = 100.06 Å, and contains two molecules in the asymmetric unit. The availability of the structure, which is being solved by molecular replacement, will provide new insights into rhesus macaque MHC I (Mamu-A*02) presenting pathogenic SIV peptides
Energy Technology Data Exchange (ETDEWEB)
Feng, Youjun [Laboratory of Molecular Immunology and Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080 (China); Graduate School, Chinese Academy of Sciences, Beijing (China); Qi, Jianxun [Graduate School, Chinese Academy of Sciences, Beijing (China); Institute of Physics, Chinese Academy of Sciences, Beijing 100080 (China); Zhang, Huimin; Wang, Jinzi [Laboratory of Molecular Immunology and Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080 (China); Liu, Jinhua [College of Veterinary Medicine, China Agricultural University, Beijing 100094 (China); Jiang, Fan [Institute of Physics, Chinese Academy of Sciences, Beijing 100080 (China); Gao, Feng, E-mail: gaofeng@im.ac.cn [Laboratory of Molecular Immunology and Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080 (China); College of Veterinary Medicine, China Agricultural University, Beijing 100094 (China)
2006-01-01
X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide. Simian immunodeficiency virus (SIV) in the rhesus macaque is regarded as a classic animal model, playing a crucial role in HIV vaccine strategies and therapeutics by characterizing various cytotoxic T-lymphocyte (CTL) responses in macaque monkeys. However, the availability of well documented structural reports focusing on rhesus macaque major histocompatibility complex class I (MHC I) molecules remains extremely limited. Here, a complex of the rhesus macaque MHC I molecule (Mamu-A*02) with human β{sub 2}m and an immunodominant SIV-Gag nonapeptide, GESNLKSLY (GY9), has been crystallized. The crystal diffracts X-rays to 2.7 Å resolution and belongs to space group C2, with unit-cell parameters a = 124.11, b = 110.45, c = 100.06 Å, and contains two molecules in the asymmetric unit. The availability of the structure, which is being solved by molecular replacement, will provide new insights into rhesus macaque MHC I (Mamu-A*02) presenting pathogenic SIV peptides.
Explorations of the extended ncKP hierarchy
International Nuclear Information System (INIS)
Dimakis, Aristophanes; Mueller-Hoissen, Folkert
2004-01-01
A recently obtained extension (xncKP) of the Moyal-deformed KP hierarchy (ncKP hierarchy) by a set of evolution equations in the Moyal-deformation parameters is further explored. Formulae are derived to compute these equations efficiently. Reductions of the xncKP hierarchy are treated, in particular to the extended ncKdV and ncBoussinesq hierarchies. Furthermore, a good part of the Sato formalism for the KP hierarchy is carried over to the generalized framework. In particular, the well-known bilinear identity theorem for the KP hierarchy, expressed in terms of the (formal) Baker-Akhiezer function, extends to the xncKP hierarchy. Moreover, it is demonstrated that N-soliton solutions of the ncKP equation are also solutions of the first few deformation equations. This is shown to be related to the existence of certain families of algebraic identities
Affine Lie algebraic origin of constrained KP hierarchies
International Nuclear Information System (INIS)
Aratyn, H.; Gomes, J.F.; Zimerman, A.H.
1994-07-01
It is presented an affine sl(n+1) algebraic construction of the basic constrained KP hierarchy. This hierarchy is analyzed using two approaches, namely linear matrix eigenvalue problem on hermitian symmetric space and constrained KP Lax formulation and we show that these approaches are equivalent. The model is recognized to be generalized non-linear Schroedinger (GNLS) hierarchy and it is used as a building block for a new class of constrained KP hierarchies. These constrained KP hierarchies are connected via similarity-Backlund transformations and interpolate between GNLS and multi-boson KP-Toda hierarchies. The construction uncovers origin of the Toda lattice structure behind the latter hierarchy. (author). 23 refs
Gauge equivalence between two-boson KP hierarchies
International Nuclear Information System (INIS)
Aratyn, H.
1994-01-01
In this paper it is explained the status of the two-boson KP hierarchy, which appears in this setting as an invariant subspace of the coadjoint orbit within the KP l=1 hierarchy. We will work with two main cases of two-boson KP hierarchies, one defined within KP l=1 hierarchy will be called Faa di Bruno KP hierarchy, while the second defined within KP hierarchy for a quadratic two-boson KP hierarchy. It will be established for them the gauge invariance playing the role of generalized Miura transformations. It is emphasized the symplectic character of equivalence of KP l=1 and KP. It is also made a point that the gauge equivalence established for two-boson systems is valid for an arbitrary n-th Poisson bracket structure and not only the first Poisson bracket structure. (author). 7 refs
Hierarchy of on-orbit servicing interfaces
Moe, Rud V.
1989-01-01
A series of equipment interfaces is involved in on-orbit servicing operations. The end-to-end hierarchy of servicing interfaces is presented. The interface concepts presented include structure and handling, and formats for transfer of resources (power, data, fluids, etc.). Consequences on cost, performance, and service ability of the use of standard designs or unique designs with interface adapters are discussed. Implications of the interface designs compatibility with remote servicing using telerobotic servicers are discussed.
Gauge hierarchy and long range forces
International Nuclear Information System (INIS)
Pal, P.B.; Keung, Wai-Yee; Chang, D.
1990-01-01
With the aid of simple examples, we show how a long range attractive force can arise in a gauge theory with a hierarchy. The force is due to the exchange of a Higgs boson whose mass and matter couplings are both naturally suppressed by the hierarchical mass ratio. Such bosons appear if there is an accidental global symmetry in the low-energy renormalizable Lagrangian after the high energy symmetry breaking. 6 refs
Do Convolutional Neural Networks Learn Class Hierarchy?
Bilal, Alsallakh; Jourabloo, Amin; Ye, Mao; Liu, Xiaoming; Ren, Liu
2018-01-01
Convolutional Neural Networks (CNNs) currently achieve state-of-the-art accuracy in image classification. With a growing number of classes, the accuracy usually drops as the possibilities of confusion increase. Interestingly, the class confusion patterns follow a hierarchical structure over the classes. We present visual-analytics methods to reveal and analyze this hierarchy of similar classes in relation with CNN-internal data. We found that this hierarchy not only dictates the confusion patterns between the classes, it furthermore dictates the learning behavior of CNNs. In particular, the early layers in these networks develop feature detectors that can separate high-level groups of classes quite well, even after a few training epochs. In contrast, the latter layers require substantially more epochs to develop specialized feature detectors that can separate individual classes. We demonstrate how these insights are key to significant improvement in accuracy by designing hierarchy-aware CNNs that accelerate model convergence and alleviate overfitting. We further demonstrate how our methods help in identifying various quality issues in the training data.
Integral equation hierarchy for continuum percolation
International Nuclear Information System (INIS)
Given, J.A.
1988-01-01
In this thesis a projection operator technique is presented that yields hierarchies of integral equations satisfied exactly by the n-point connectedness functions in a continuum version of the site-bond percolation problem. The n-point connectedness functions carry the same structural information for a percolation problem as then-point correlation functions do for a thermal problem. This method extends the Potts model mapping of Fortuin and Kastelyn to the continuum by exploiting an s-state generalization of the Widom-Rowlinson model, a continuum model for phase separation. The projection operator technique is used to produce an integral equation hierarchy for percolation similar to the Born-Green heirarchy. The Kirkwood superposition approximation (SA) is extended to percolation in order to close this hierarchy and yield a nonlinear integral equation for the two-point connectedness function. The fact that this function, in the SA, is the analytic continuation to negative density of the two-point correlation function in a corresponding thermal problem is discussed. The BGY equation for percolation is solved numerically, both by an expansion in powers of the density, and by an iterative technique due to Kirkwood. It is argued both analytically and numerically, that the BYG equation for percolation, unlike its thermal counterpart, shows non-classical critical behavior, with η = 1 and γ = 0.05 ± .1. Finally a sequence of refinements to the superposition approximations based in the theory of fluids by Rice and Lekner is discussed
Collaborative hierarchy maintains cooperation in asymmetric games.
Antonioni, Alberto; Pereda, María; Cronin, Katherine A; Tomassini, Marco; Sánchez, Angel
2018-03-29
The interplay of social structure and cooperative behavior is under much scrutiny lately as behavior in social contexts becomes increasingly relevant for everyday life. Earlier experimental work showed that the existence of a social hierarchy, earned through competition, was detrimental for the evolution of cooperative behaviors. Here, we study the case in which individuals are ranked in a hierarchical structure based on their performance in a collective effort by having them play a Public Goods Game. In the first treatment, participants are ranked according to group earnings while, in the second treatment, their rankings are based on individual earnings. Subsequently, participants play asymmetric Prisoner's Dilemma games where higher-ranked players gain more than lower ones. Our experiments show that there are no detrimental effects of the hierarchy formed based on group performance, yet when ranking is assigned individually we observe a decrease in cooperation. Our results show that different levels of cooperation arise from the fact that subjects are interpreting rankings as a reputation which carries information about which subjects were cooperators in the previous phase. Our results demonstrate that noting the manner in which a hierarchy is established is essential for understanding its effects on cooperation.
Minimal string theories and integrable hierarchies
Iyer, Ramakrishnan
Well-defined, non-perturbative formulations of the physics of string theories in specific minimal or superminimal model backgrounds can be obtained by solving matrix models in the double scaling limit. They provide us with the first examples of completely solvable string theories. Despite being relatively simple compared to higher dimensional critical string theories, they furnish non-perturbative descriptions of interesting physical phenomena such as geometrical transitions between D-branes and fluxes, tachyon condensation and holography. The physics of these theories in the minimal model backgrounds is succinctly encoded in a non-linear differential equation known as the string equation, along with an associated hierarchy of integrable partial differential equations (PDEs). The bosonic string in (2,2m-1) conformal minimal model backgrounds and the type 0A string in (2,4 m) superconformal minimal model backgrounds have the Korteweg-de Vries system, while type 0B in (2,4m) backgrounds has the Zakharov-Shabat system. The integrable PDE hierarchy governs flows between backgrounds with different m. In this thesis, we explore this interesting connection between minimal string theories and integrable hierarchies further. We uncover the remarkable role that an infinite hierarchy of non-linear differential equations plays in organizing and connecting certain minimal string theories non-perturbatively. We are able to embed the type 0A and 0B (A,A) minimal string theories into this single framework. The string theories arise as special limits of a rich system of equations underpinned by an integrable system known as the dispersive water wave hierarchy. We find that there are several other string-like limits of the system, and conjecture that some of them are type IIA and IIB (A,D) minimal string backgrounds. We explain how these and several other string-like special points arise and are connected. In some cases, the framework endows the theories with a non
Hierarchy, Dominance, and Deliberation: Egalitarian Values Require Mental Effort.
Van Berkel, Laura; Crandall, Christian S; Eidelman, Scott; Blanchar, John C
2015-09-01
Hierarchy and dominance are ubiquitous. Because social hierarchy is early learned and highly rehearsed, the value of hierarchy enjoys relative ease over competing egalitarian values. In six studies, we interfere with deliberate thinking and measure endorsement of hierarchy and egalitarianism. In Study 1, bar patrons' blood alcohol content was correlated with hierarchy preference. In Study 2, cognitive load increased the authority/hierarchy moral foundation. In Study 3, low-effort thought instructions increased hierarchy endorsement and reduced equality endorsement. In Study 4, ego depletion increased hierarchy endorsement and caused a trend toward reduced equality endorsement. In Study 5, low-effort thought instructions increased endorsement of hierarchical attitudes among those with a sense of low personal power. In Study 6, participants' thinking quickly allocated more resources to high-status groups. Across five operationalizations of impaired deliberative thought, hierarchy endorsement increased and egalitarianism receded. These data suggest hierarchy may persist in part because it has a psychological advantage. © 2015 by the Society for Personality and Social Psychology, Inc.
Rouse, R A
1991-01-01
Work by both advertising and health researchers has independently yielded hierarchy of effects models which can be used to predict campaign success. Unfortunately, however, previous work has been criticized as "common sense" approaches which are more "assumed" than "proven." This analysis argues that much of the problem is due to the lack of precision often associated with over-simplified "uni-dimensional" models. Instead, this perspective synthesized a "two-dimensional" health hierarchy of effects model and outlines a pragmatic strategy for campaign measurement.
A classical-quantum coupling strategy for a hierarchy of one dimensional models for semiconductors
Jourdana, Clément; Pietra, Paola; Vauchelet, Nicolas
2014-01-01
We consider one dimensional coupled classical-quantum models for quantum semiconductor device simulations. The coupling occurs in the space variable : the domain of the device is divided into a region with strong quantum effects (quantum zone) and a region where quantum effects are negligible (classical zone). In the classical zone, transport in diffusive approximation is modeled through diffusive limits of the Boltzmann transport equation. This leads to a hierarchy of classical model. The qu...
Directory of Open Access Journals (Sweden)
Janice K. P. Lam
2018-03-01
Full Text Available Long term carriers were shown to generate robust polyfunctional T cell (PFC responses against lytic and latent antigens of Epstein-Barr virus (EBV. However, the time of emergence of PFC responses against EBV antigens, pattern of immunodominance and difference between CD4+ and CD8+ T cell responses during various stages of EBV infection are not clearly understood. A longitudinal study was performed to assess the development of antigen-specific PFC responses in children diagnosed to have primary symptomatic (infectious mononucleosis [IM] and asymptomatic (AS EBV infection. Evaluation of IFN-γ secreting CD8+ T cell responses upon stimulation by HLA class I-specific peptides of EBV lytic and latent proteins by ELISPOT assay followed by assessment of CD4+ and CD8+ PFC responses upon stimulation by a panel of overlapping EBV peptides for co-expression of IFN-γ, TNF-α, IL-2, perforin and CD107a by flow cytometry were performed. Cytotoxicity of T cells against autologous lymphoblastoid cell lines (LCLs as well as EBV loads in PBMC and plasma were also determined. Both IM and AS patients had elevated PBMC and plasma viral loads which declined steadily during a 12-month period from the time of diagnosis whilst decrease in the magnitude of CD8+ T cell responses toward EBV lytic peptides in contrast to increase toward latent peptides was shown with no significant difference between those of IM and AS patients. Both lytic and latent antigen-specific CD4+ and CD8+ T cells demonstrated polyfunctionality (defined as greater or equal to three functions concurrent with enhanced cytotoxicity against autologous LCLs and steady decrease in plasma and PBMC viral loads over time. Immunodominant peptides derived from BZLF1, BRLF1, BMLF1 and EBNA3A-C proteins induced the highest proportion of CD8+ as well as CD4+ PFC responses. Diverse functional subtypes of both CD4+ and CD8+ PFCs were shown to emerge at 6–12 months. In conclusion, EBV antigen-specific CD4+ and CD
Directory of Open Access Journals (Sweden)
Kam Leng Aw-Yong
Full Text Available Enterovirus A71 (EV-A71 is one of the main causative agents of hand, foot and mouth disease (HFMD. Unlike other enteroviruses that cause HFMD, EV-A71 is more frequently associated with severe neurological complications and fatality. To date, no effective licensed antivirals are available to combat EV-A71 infection. Little is known about the immunogenicity of viral non-structural proteins in humans. Previous studies have mainly focused on characterization of epitopes of EV-A71 structural proteins by using immunized animal antisera. In this study, we have characterized human antibody responses against the structural and non-structural proteins of EV-A71. Each viral protein was cloned and expressed in either bacterial or mammalian systems, and tested with antisera by western blot. Results revealed that all structural proteins (VP1-4, and non-structural proteins 2A, 3C and 3D were targets of EV-A71 IgM, whereas EV-A71 IgG recognized all the structural and non-structural proteins. Sixty three synthetic peptides predicted to be immunogenic in silico were synthesized and used for the characterization of EV-A71 linear B-cell epitopes. In total, we identified 22 IgM and four IgG dominant epitopes. Synthetic peptide PEP27, corresponding to residues 142-156 of VP1, was identified as the EV-A71 IgM-specific immunodominant epitope. PEP23, mapped to VP1 41-55, was recognized as the EV-A71 IgG cross-reactive immunodominant epitope. The structural protein VP1 is the major immunodominant site targeted by anti-EV-A71 IgM and IgG antibodies, but epitopes against non-structural proteins were also detected. These data provide new understanding of the immune response to EV-A71 infection, which benefits the development of diagnostic tools, potential therapeutics and subunit vaccine candidates.
Physical interpretation of the combinatorial hierarchy
International Nuclear Information System (INIS)
Bastin, T.; Noyes, H.P.
1978-01-01
The combinatorial hierarchy model for base particle processes is compared and contrasted with the Ur-theory as developed at the Tutzing Conferences. It agrees with Ur-theory about a finite basis, the ''fixed past--uncertain future'' aspects of physics, and the necessity of dropping Bohr's requirement of reduction to the haptic language of commonsense and classical physics. However, it retains a constructive, hierarchial approach with can yield only an approximate and discrete ''space time'', and introduces the observation metaphysic at the start. Concrete interpretation of the four levels of the hierarchy (with cardinals 3, 7, 127, 2 127 -1 approx. =10 38 ) associates the three levels which map up and down with three absolute conservation laws (charge, baryon number, lepton number) and the spin dichotomy. The first level represents +, -, and +- unit charge. The second has the quantum nubmers of a baryon--antibaryon pair and associated charged meson (e.g., n anti n, p anti n, p anti p, n anti p, π + , π 0 , π - ). The third level associates this pair, now including four spin states as well as four charge states, with a neutral lepton--antilepton pair (e anti e or ν anti ν) in four spin states (total, 64 states): three charged spinless, three charged spin-1, and neutral spin-1 mesons (15 states), and a neutral vector boson associated with the leptons; this gives 3 + 15 + 3 x 15 = 63 possible boson states, so a total correct count of 63 + 64 = 127 states. Something like SU 2 X SU 3 and other indications of quark quantum numbers can occur as substructures at the fourth (unstable) level. A slight extension gives the usual static approximation to the building energy of the hydrogen atom, α 2 m/sub e/c 2 . Cosmological implications of the theory are in accord with current experience. A beginning in the physical interpretation of a theory which could eventually encompass all branches of physics was made. 3 figures, 6 tables
Ando, Shin'ichiro; Sato, Katsuhiko
2003-10-01
Resonant spin-flavour (RSF) conversions of supernova neutrinos, which are induced by the interaction between the nonzero neutrino magnetic moment and supernova magnetic fields, are studied for both normal and inverted mass hierarchy. As the case for the pure matter-induced neutrino oscillation (Mikheyev–Smirnov–Wolfenstein (MSW) effect), we find that the RSF transitions are strongly dependent on the neutrino mass hierarchy as well as the value of θ13. Flavour conversions are solved numerically for various neutrino parameter sets, with the presupernova profile calculated by Woosley and Weaver. In particular, it is very interesting that the RSF-induced νe→bar nue transition occurs if the following conditions are all satisfied: the value of μνB (μν is the neutrino magnetic moment and B is the magnetic field strength) is sufficiently strong, the neutrino mass hierarchy is inverted, and the value of θ13 is large enough to induce adiabatic MSW resonance. In this case, the strong peak due to the original νe emitted from the neutronization burst would exist in the time profile of the neutrino events detected at the Super-Kamiokande detector. If this peak were observed in reality, it would provide fruitful information on the neutrino properties. On the other hand, the characteristics of the neutrino spectra are also different between the neutrino models, but we find that there remains degeneracy among several models. Dependence on presupernova models is also discussed.
Asymptotic density and the Ershov hierarchy
Downey, Rod; Jockusch, Carl; McNicholl, Timothy H.; Schupp, Paul
2013-01-01
We classify the asymptotic densities of the $\\Delta^0_2$ sets according to their level in the Ershov hierarchy. In particular, it is shown that for $n \\geq 2$, a real $r \\in [0,1]$ is the density of an $n$-c.e.\\ set if and only if it is a difference of left-$\\Pi_2^0$ reals. Further, we show that the densities of the $\\omega$-c.e.\\ sets coincide with the densities of the $\\Delta^0_2$ sets, and there are $\\omega$-c.e.\\ sets whose density is not the density of an $n$-c.e. set for any $n \\in \\ome...
From fusion hierarchy to excited state TBA
International Nuclear Information System (INIS)
Juettner, G.; Kluemper, A.
1998-01-01
Functional relations among the fusion hierarchy of quantum transfer matrices give a novel derivation of the TBA equations, namely without string hypothesis. This is demonstrated for two important models of 1D highly correlated electron systems, the supersymmetric t-J model and the supersymmetric extended Hubbard model. As a consequence, ''the excited state TBA'' equations, which characterize correlation lengths, are explicitly derived for the t-J model. To the authors' knowledge, this is the first explicit derivation of excited state TBA equations for 1D lattice electron systems. (orig.)
Revaluing the hierarchy of paper recycling
International Nuclear Information System (INIS)
Samakovlis, Eva
2004-01-01
This article revalues the hierarchy of paper waste management policies in a dynamic general equilibrium model. Incineration, material recycling and the distinction between non-renewable fossil fuels and renewable forest assets are incorporated. By comparing the first order conditions from the command optimum with the conditions from the market model, it is discovered that the unregulated market fails to create an optimal resource allocation. To see how the market behaves, in absence of environmental policy, compared to the first best solution a numerical model is used. Pigouvian taxes and subsidies are derived to correct for the externalities
Stability of mass hierarchy in models with a sliding singlet
International Nuclear Information System (INIS)
Smirnov, A.Yu.; Tainov, E.A.
1986-01-01
In the broad class of models with a heavy sliding singlet and softly broken supersymmetry (e.g. by the effects of N=1 supergravity) it is shown that the doublet-triplet hierarchy obtained at the tree level is not destroyed by quantum correction at any loop order. As an example the simplest SU(5) model with a stable doublet-triplet hierarchy is proposed. The necessary and sufficient conditions of the hierarchy stability are discussed. (orig.)
Baecklund transformation of the noncommutative Gelfand-Dickey hierarchy
International Nuclear Information System (INIS)
Zheng Zhong; He Jingsong; Cheng Yi
2004-01-01
We study the Baecklund transformation of the noncommutative Gelfand-Dickey(ncGD) hierarchy. By factorizing its Lax operator into the multiplication form of first order differential operator, the noncommutative modified KdV(ncMKdV) hierarchy and the Miura transformations are defined. Our results show that the ncMKdV equations are invariant under the cyclic permutation, and hence induces the Baecklund transformation of the ncGD hierarchy. (author)
Self-organizing dominance hierarchies in a wild primate population
Franz, Mathias; McLean, Emily; Tung, Jenny; Altmann, Jeanne; Alberts, Susan C.
2015-01-01
Linear dominance hierarchies, which are common in social animals, can profoundly influence access to limited resources, reproductive opportunities and health. In spite of their importance, the mechanisms that govern the dynamics of such hierarchies remain unclear. Two hypotheses explain how linear hierarchies might emerge and change over time. The ‘prior attributes hypothesis’ posits that individual differences in fighting ability directly determine dominance ranks. By contrast, the ‘social d...
The Theory of Ratio Scale Estimation: Saaty's Analytic Hierarchy Process
Patrick T. Harker; Luis G. Vargas
1987-01-01
The Analytic Hierarchy Process developed by Saaty (Saaty, T. L. 1980. The Analytic Hierarchy Process. McGraw-Hill, New York.) has proven to be an extremely useful method for decision making and planning. However, some researchers in these areas have raised concerns over the theoretical basis underlying this process. This paper addresses currently debated issues concerning the theoretical foundations of the Analytic Hierarchy Process. We also illustrate through proof and through examples the v...
When Do Types Induce the Same Belief Hierarchy?
Directory of Open Access Journals (Sweden)
Andrés Perea
2016-10-01
Full Text Available Type structures are a simple device to describe higher-order beliefs. However, how can we check whether two types generate the same belief hierarchy? This paper generalizes the concept of a type morphism and shows that one type structure is contained in another if and only if the former can be mapped into the other using a generalized type morphism. Hence, every generalized type morphism is a hierarchy morphism and vice versa. Importantly, generalized type morphisms do not make reference to belief hierarchies. We use our results to characterize the conditions under which types generate the same belief hierarchy.
The Toda lattice hierarchy and deformation of conformal field theories
International Nuclear Information System (INIS)
Fukuma, M.
1990-01-01
In this paper, the authors point out that the Toda lattice hierarchy known in soliton theory is relevant for the description of the deformations of conformal field theories while the KP hierarchy describes unperturbed conformal theories. It is shown that the holomorphic parts of the conserved currents in the perturbed system (the Toda lattice hierarchy) coincide with the conserved currents in the KP hierarchy and can be written in terms of the W-algebraic currents. Furthermore, their anti-holomorphic counterparts are obtained
On Recursion Operator of the q -KP Hierarchy
International Nuclear Information System (INIS)
Tian Ke-Lei; Zhu Xiao-Ming; He Jing-Song
2016-01-01
It is the aim of the present article to give a general expression of flow equations of the q-KP hierarchy. The distinct difference between the q-KP hierarchy and the KP hierarchy is due to q-binomial and the action of q-shift operator θ, which originates from the Leibnitz rule of the quantum calculus. We further show that the n-reduction leads to a recursive scheme for these flow equations. The recursion operator for the flow equations of the q-KP hierarchy under the n-reduction is also derived. (paper)
An extended integrable fractional-order KP soliton hierarchy
International Nuclear Information System (INIS)
Li Li
2011-01-01
In this Letter, we consider the modified derivatives and integrals of fractional-order pseudo-differential operators. A sequence of Lax KP equations hierarchy and extended fractional KP (fKP) hierarchy are introduced, and the fKP hierarchy has Lax presentations with the extended Lax operators. In the case of the extension with the half-order pseudo-differential operators, a new integrable fKP hierarchy is obtained. A few particular examples of fractional order will be listed, together with their Lax pairs.
The analytic hierarchy process as a support for decision making
Directory of Open Access Journals (Sweden)
Filipović Milanka
2007-01-01
Full Text Available The first part of this text deals with a convention site selection as one of the most lucrative areas in the tourism industry. The second part gives a further description of a method for decision making - the analytic hierarchy process. The basic characteristics: hierarchy constructions and pair wise comparison on the given level of the hierarchy are allured. The third part offers an example of application. This example is solved using the Super - Decision software, which is developed as a computer support for the analytic hierarchy process. This indicates that the AHP approach is a useful tool to help support a decision of convention site selection. .
An extended integrable fractional-order KP soliton hierarchy
Energy Technology Data Exchange (ETDEWEB)
Li Li, E-mail: li07099@163.co [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China)
2011-01-17
In this Letter, we consider the modified derivatives and integrals of fractional-order pseudo-differential operators. A sequence of Lax KP equations hierarchy and extended fractional KP (fKP) hierarchy are introduced, and the fKP hierarchy has Lax presentations with the extended Lax operators. In the case of the extension with the half-order pseudo-differential operators, a new integrable fKP hierarchy is obtained. A few particular examples of fractional order will be listed, together with their Lax pairs.
Redford, Liz; Ratliff, Kate A
2018-01-01
People punish others for various reasons, including deterring future crime, incapacitating the offender, and retribution, or payback. The current research focuses on retribution, testing whether support for retribution is motivated by the desire to maintain social hierarchies. If so, then the retributive tendencies of hierarchy enhancers or hierarchy attenuators should depend on whether offenders are relatively lower or higher in status, respectively. Three studies showed that hierarchy attenuators were more retributive against high-status offenders than for low-status offenders, that hierarchy enhancers showed a stronger orientation towards retributive justice, and that relationship was stronger for low-status, rather than high-status, criminal offenders. These findings clarify the purpose and function of retributive punishment. They also reveal how hierarchy-regulating motives underlie retribution, motives which, if allowed to influence judgements, may contribute to biased or ineffective justice systems. © 2017 The British Psychological Society.
On hierarchical solutions to the BBGKY hierarchy
Hamilton, A. J. S.
1988-01-01
It is thought that the gravitational clustering of galaxies in the universe may approach a scale-invariant, hierarchical form in the small separation, large-clustering regime. Past attempts to solve the Born-Bogoliubov-Green-Kirkwood-Yvon (BBGKY) hierarchy in this regime have assumed a certain separable hierarchical form for the higher order correlation functions of galaxies in phase space. It is shown here that such separable solutions to the BBGKY equations must satisfy the condition that the clustered component of the solution has cluster-cluster correlations equal to galaxy-galaxy correlations to all orders. The solutions also admit the presence of an arbitrary unclustered component, which plays no dyamical role in the large-clustering regime. These results are a particular property of the specific separable model assumed for the correlation functions in phase space, not an intrinsic property of spatially hierarchical solutions to the BBGKY hierarchy. The observed distribution of galaxies does not satisfy the required conditions. The disagreement between theory and observation may be traced, at least in part, to initial conditions which, if Gaussian, already have cluster correlations greater than galaxy correlations.
Hierarchies without symmetries from extra dimensions
International Nuclear Information System (INIS)
Arkani-Hamed, Nima; Schmaltz, Martin
2000-01-01
It is commonly thought that small couplings in a low-energy theory, such as those needed for the fermion mass hierarchy or proton stability, must originate from symmetries in a high-energy theory. We show that this expectation is violated in theories where the standard model fields are confined to a thick wall in extra dimensions, with the fermions ''stuck'' at different points in the wall. Couplings between them are then suppressed due to the exponentially small overlaps of their wave functions. This provides a framework for understanding both the fermion mass hierarchy and proton stability without imposing symmetries, but rather in terms of higher dimensional geography. A model independent prediction of this scenario is non-universal couplings of the standard model fermions to the ''Kaluza-Klein'' excitations of the gauge fields. This allows a measurement of the fermion locations in the extra dimensions at the CERN LHC or NLC if the wall thickness is close to the TeV scale. (c) 2000 The American Physical Society
Hierarchies Without Symmetries from Extra Dimensions
International Nuclear Information System (INIS)
Arkani-Hamed, Nima
1999-01-01
It is commonly thought that small couplings in a low-energy theory, such as those needed for the fermion mass hierarchy or proton stability, must originate from symmetries in a high-energy theory. We show that this expectation is violated in theories where the Standard Model fields are confined to a thick wall in extra dimensions, with the fermions ''stuck'' at different points in the wall. Couplings between them are then suppressed due to the exponentially small overlaps of their wave functions. This provides a framework for understanding both the fermion mass hierarchy and proton stability without imposing symmetries, but rather in terms of higher dimensional geography. A model independent prediction of this scenario is non-universal couplings of the Standard Model fermions to the ''Kaluza-Klein'' excitations of the gauge fields. This allows a measurement of the fermion locations in the extra dimensions at the LHC or NLC if the wall thickness is close to the TeV scale
A color hierarchy for automatic target selection.
Directory of Open Access Journals (Sweden)
Illia Tchernikov
Full Text Available Visual processing of color starts at the cones in the retina and continues through ventral stream visual areas, called the parvocellular pathway. Motion processing also starts in the retina but continues through dorsal stream visual areas, called the magnocellular system. Color and motion processing are functionally and anatomically discrete. Previously, motion processing areas MT and MST have been shown to have no color selectivity to a moving stimulus; the neurons were colorblind whenever color was presented along with motion. This occurs when the stimuli are luminance-defined versus the background and is considered achromatic motion processing. Is motion processing independent of color processing? We find that motion processing is intrinsically modulated by color. Color modulated smooth pursuit eye movements produced upon saccading to an aperture containing a surface of coherently moving dots upon a black background. Furthermore, when two surfaces that differed in color were present, one surface was automatically selected based upon a color hierarchy. The strength of that selection depended upon the distance between the two colors in color space. A quantifiable color hierarchy for automatic target selection has wide-ranging implications from sports to advertising to human-computer interfaces.
Gauge hierarchy problem in grand unified theories
International Nuclear Information System (INIS)
Alhendi, H.A.A.
1982-01-01
In grand unification schemes, several mass scales are to be introduced, with some of them much larger than all the others, to cope with experimental observations, in which elementary particles of higher masses require higher energy to observe them than elementary particles of lower masses. There have been controversial arguments in the literature on such hierarchical scale structure, when radiative corrections are taken into account. It has been asserted that the gauge hierarchy depends on the choice of the subtraction point (in the classical field space), of the four-point function at zero external momentum. It also has been asserted that the gauge hierarchy problem whenever it is possible to be maintained in one sector of particles, it also is possible to be maintained in the other sectors. These two problems have been studied in a prototype model, namely an 0(3)-model with two triplets of real scalar Higgs fields. Our analysis shows that, within ordinary perturbation theory, none of these two problems is quite correct
Adapting Memory Hierarchies for Emerging Datacenter Interconnects
Institute of Scientific and Technical Information of China (English)
江涛; 董建波; 侯锐; 柴琳; 张立新; 孙凝晖; 田斌
2015-01-01
Eﬃcient resource utilization requires that emerging datacenter interconnects support both high performance communication and eﬃcient remote resource sharing. These goals require that the network be more tightly coupled with the CPU chips. Designing a new interconnection technology thus requires considering not only the interconnection itself, but also the design of the processors that will rely on it. In this paper, we study memory hierarchy implications for the design of high-speed datacenter interconnects—particularly as they affect remote memory access—and we use PCIe as the vehicle for our investigations. To that end, we build three complementary platforms: a PCIe-interconnected prototype server with which we measure and analyze current bottlenecks; a software simulator that lets us model microarchitectural and cache hierarchy changes;and an FPGA prototype system with a streamlined switchless customized protocol Thunder with which we study hardware optimizations outside the processor. We highlight several architectural modifications to better support remote memory access and communication, and quantify their impact and limitations.
Directory of Open Access Journals (Sweden)
Hsin-Wei Chen
Full Text Available Dengue is the leading cause of mosquito-borne viral infections and no vaccine is available now. Envelope protein domain III (ED3 is the major target for the binding of dengue virus neutralizing antibodies; however, the ED3-specifc T-cell response is less well understood. To investigate the T-cell responses to four serotypes of dengue virus (DENV-1 to 4, we immunized mice using either a tetravalent ED3-based DNA or protein vaccine, or combined both as a DNA prime-protein boost strategy (prime-boost. A significant serotype-dependent IFN-γ or IL-4 response was observed in mice immunized with either the DNA or protein vaccine. The IFN-γ response was dominant to DENV-1 to 3, whereas the IL-4 response was dominant to DENV-4. Although the similar IgG titers for the four serotypes were observed in mice immunized with the tetravalent vaccines, the neutralizing antibody titers varied and followed the order of 2 = 3>1>4. Interestingly, the lower IFN-γ response to DENV-4 is attributable to the immunodominance change between two CD4+ T-cell epitopes; one T-cell epitope located at E349-363 of DENV-1 to 3 was more immunogenic than the DENV-4 epitope E313-327. Despite DENV-4 specific IFN-γ responses were suppressed by immunodominance change, either DENV-4-specific IFN-γ or neutralizing antibody responses were still recalled after DENV-4 challenge and contributed to virus clearance. Immunization with the prime-boost elicited both IFN-γ and neutralizing antibody responses and provided better protection than either DNA or protein immunization. Our findings shed light on how ED3-based tetravalent dengue vaccines sharpen host CD4 T-cell responses and contribute to protection against dengue virus.
Formulating weak CP-violation in terms of quark mass hierarchies
International Nuclear Information System (INIS)
Davidson, A.
1982-06-01
That physics which explains Cabibbo mixing is shown to also put a lower bound on Kobayashi-Maskawa CP-violation. The observed amount epsilon = 0.002 of CP-violation in the Ksub(L) - Ksub(S) system in turn sharply requires 25 GeV <= msub(t) <= 59 GeV; msub(t) being the top-quark mass. Assuming a vanishing weak (ala strong) CP-violation amplitude for msub(u) → 0, as strongly indicated by the data, epsilon is formulated as a second order quantity in the fermionic mass hierarchy. (author)
Biological hierarchies and the nature of extinction.
Congreve, Curtis R; Falk, Amanda R; Lamsdell, James C
2018-05-01
Hierarchy theory recognises that ecological and evolutionary units occur in a nested and interconnected hierarchical system, with cascading effects occurring between hierarchical levels. Different biological disciplines have routinely come into conflict over the primacy of different forcing mechanisms behind evolutionary and ecological change. These disconnects arise partly from differences in perspective (with some researchers favouring ecological forcing mechanisms while others favour developmental/historical mechanisms), as well as differences in the temporal framework in which workers operate. In particular, long-term palaeontological data often show that large-scale (macro) patterns of evolution are predominantly dictated by shifts in the abiotic environment, while short-term (micro) modern biological studies stress the importance of biotic interactions. We propose that thinking about ecological and evolutionary interactions in a hierarchical framework is a fruitful way to resolve these conflicts. Hierarchy theory suggests that changes occurring at lower hierarchical levels can have unexpected, complex effects at higher scales due to emergent interactions between simple systems. In this way, patterns occurring on short- and long-term time scales are equally valid, as changes that are driven from lower levels will manifest in different forms at higher levels. We propose that the dual hierarchy framework fits well with our current understanding of evolutionary and ecological theory. Furthermore, we describe how this framework can be used to understand major extinction events better. Multi-generational attritional loss of reproductive fitness (MALF) has recently been proposed as the primary mechanism behind extinction events, whereby extinction is explainable solely through processes that result in extirpation of populations through a shutdown of reproduction. While not necessarily explicit, the push to explain extinction through solely population-level dynamics
Variable-coefficient nonisospectral Toda lattice hierarchy and its
Indian Academy of Sciences (India)
In this paper, a hierarchy of nonisospectral equations with variable coefficients is derived from the compatibility condition of Toda spectral problem and its time evolution. In order to solve the derived Toda lattice hierarchy, the inverse scattering transformation is utilized. As a result, new and more general exact solutions are ...
Criteria for optimizing cortical hierarchies with continuous ranges
Directory of Open Access Journals (Sweden)
Antje Krumnack
2010-03-01
Full Text Available In a recent paper (Reid et al.; 2009, NeuroImage we introduced a method to calculate optimal hierarchies in the visual network that utilizes continuous, rather than discrete, hierarchical levels, and permits a range of acceptable values rather than attempting to fit fixed hierarchical distances. There, to obtain a hierarchy, the sum of deviations from the constraints that define the hierarchy was minimized using linear optimization. In the short time since publication of that paper we noticed that many colleagues misinterpreted the meaning of the term optimal hierarchy. In particular, a majority of them were under the impression that there was perhaps only one optimal hierarchy, but a substantial difficulty in finding that one. However, there is not only more than one optimal hierarchy but also more than one option for defining optimality. Continuing the line of this work we look at additional options for optimizing the visual hierarchy: minimizing the number of violated constraints and minimizing the maximal size of a constraint violation using linear optimization and mixed integer programming. The implementation of both optimization criteria is explained in detail. In addition, using constraint sets based on the data from Felleman and Van Essen, optimal hierarchies for the visual network are calculated for both optimization methods.
An alternative approach to KP hierarchy in matrix models
International Nuclear Information System (INIS)
Bonora, L.; Xiong, C.S.
1992-01-01
We show that there exists an alternative procedure in order to extract differential hierarchies, such as the KdV hierarchy, from one-matrix models, without taking a continuum limit. To prove this we introduce the Toda lattice and reformulate it in operator form. We then consider the reduction to the systems appropriate for a one-matrix model. (orig.)
Nonlinear Super Integrable Couplings of Super Classical-Boussinesq Hierarchy
Directory of Open Access Journals (Sweden)
Xiuzhi Xing
2014-01-01
Full Text Available Nonlinear integrable couplings of super classical-Boussinesq hierarchy based upon an enlarged matrix Lie super algebra were constructed. Then, its super Hamiltonian structures were established by using super trace identity. As its reduction, nonlinear integrable couplings of the classical integrable hierarchy were obtained.
Inequality Matters : Classroom Status Hierarchy and Adolescents' Bullying
Garandeau, Claire F.; Lee, Ihno A.; Salmivalli, Christina
2014-01-01
The natural emergence of status hierarchies in adolescent peer groups has long been assumed to help prevent future intragroup aggression. However, clear evidence of this beneficial influence is lacking. In fact, few studies have examined between-group differences in the degree of status hierarchy
Towards Lax Formulation of Integrable Hierarchies of Topological Type
Carlet, G.; van de Leur, J.; Posthuma, H.; Shadrin, S.
2014-01-01
To each partition function of cohomological field theory one can associate an Hamiltonian integrable hierarchy of topological type. The Givental group acts on such partition functions and consequently on the associated integrable hierarchies. We consider the Hirota and Lax formulations of the
Towards Lax Formulation of Integrable Hierarchies of Topological Type
van de Leur, Johannes; Carlet, Guido; Shadrin, Sergey; Posthuma, Hessel
2014-01-01
To each partition function of cohomological field theory one can associate an Hamiltonian integrable hierarchy of topological type. The Givental group acts on such partition functions and consequently on the associated integrable hierarchies. We consider theHirota and Lax formulations of the
A Validation Study of Maslow's Hierarchy of Needs Theory.
Clay, Rex J.
A study was conducted to expand the body of research that tests the validity of Abraham Maslow's hierarchy of needs theory in a work context where it often serves as a guide for the supervisor's relationships with his subordinates. Data was gathered by questionnaire which tested for a hierarchy of needs among instructors at four community colleges…
Gauge theories, duality relations and the tensor hierarchy
Bergshoeff, Eric A.; Hartong, Jelle; Hohm, Olaf; Huebscher, Mechthild; Ortin, Tomas; Hübscher, Mechthild
We compute the complete 3- and 4-dimensional tensor hierarchies, i.e. sets of p-form fields, with 1 We construct gauge-invariant actions that include all the fields in the tensor hierarchies. We elucidate the relation between the gauge transformations of the p-form fields in the action and those of
A Second Look at Maslow's Hierarchy of Basic Needs.
White, Charles M.
Implications of Maslow's Need Hierarchy are considered in this paper, along with possible qualifications to the suggested structure and potential effects of superimposing relative deprivation theory onto the hierarchy as an approach to adult education. The interfacing of needs and alternative structurings is discussed in terms of two theories: (1)…
The Diversity Education Dilemma: Exposing Status Hierarchies without Reinforcing Them
Amoroso, Lisa M.; Loyd, Denise Lewin; Hoobler, Jenny M.
2010-01-01
A "diversity education dilemma" occurs when exposure to information concerning status hierarchies, related to demographic and other socially salient identity groups, reinforces those hierarchies in the classroom. Discussions of diversity-related issues in a variety of management courses (e.g., immigrant issues in labor relations, the composition…
Inverted hierarchy and asymptotic freedom in grand unified supersymmetric theories
International Nuclear Information System (INIS)
Aratyn, H.
1983-01-01
The interrelation between an inverted hierarchy mechanism and asymptotic freedom in supersymmetric theories is analyzed in two models for which we performed a detailed analysis of the effective potentials and effective couplings. We find it difficult to accommodate an inverted hierarchy together with asymptotic freedom for the matter-Yukawa couplings. (orig.)
A Computational Glimpse at the Leibniz and Frege Hierarchies
Czech Academy of Sciences Publication Activity Database
Moraschini, Tommaso
2018-01-01
Roč. 169, č. 1 (2018), s. 1-20 ISSN 0168-0072 R&D Projects: GA ČR GA13-14654S Institutional support: RVO:67985807 Keywords : abstract algebraic logic * Leibniz hierarchy * Frege hierarchy Leibniz congruence * decidability * Diophantine equations * relation algebras Subject RIV: BA - General Mathematics Impact factor: 0.647, year: 2016
Determination of neutrino mass hierarchy by 21 cm line and CMB B-mode polarization observations
Energy Technology Data Exchange (ETDEWEB)
Oyama, Yoshihiko, E-mail: oyamayo@post.kek.jp [The Graduate University for Advanced Studies (SOKENDAI), 1-1 Oho, Tsukuba 305-0801 (Japan); Shimizu, Akie [The Graduate University for Advanced Studies (SOKENDAI), 1-1 Oho, Tsukuba 305-0801 (Japan); Kohri, Kazunori [The Graduate University for Advanced Studies (SOKENDAI), 1-1 Oho, Tsukuba 305-0801 (Japan); Institute of Particle and Nuclear Studies, KEK, 1-1 Oho, Tsukuba 305-0801 (Japan)
2013-01-29
We focus on the ongoing and future observations for both the 21 cm line and the CMB B-mode polarization produced by a CMB lensing, and study their sensitivities to the effective number of neutrino species, the total neutrino mass, and the neutrino mass hierarchy. We find that combining the CMB observations with future square kilometer arrays optimized for 21 cm line such as Omniscope can determine the neutrino mass hierarchy at 2{sigma}. We also show that a more feasible combination of Planck + POLARBEAR and SKA can strongly improve errors of the bounds on the total neutrino mass and the effective number of neutrino species to be {Delta}{Sigma}m{sub {nu}}{approx}0.12 eV and {Delta}N{sub {nu}}{approx}0.38 at 2{sigma}, respectively.
Predicting {theta}{sub 13} and the neutrino mass scale from quark lepton mass hierarchies
Energy Technology Data Exchange (ETDEWEB)
Buchmueller, W.; Domcke, V.; Schmitz, K.
2011-11-15
Flavour symmetries of Froggatt-Nielsen type can naturally reconcile the large quark and charged lepton mass hierarchies and the small quark mixing angles with the observed small neutrino mass hierarchies and their large mixing angles. We point out that such a flavour structure, together with the measured neutrino mass squared differences and mixing angles, strongly constrains yet undetermined parameters of the neutrino sector. Treating unknown O(1) parameters as random variables, we obtain surprisingly accurate predictions for the smallest mixing angle, sin{sup 2}2{theta}{sub 13}=0.07{sup +0.11}{sub -0.05}, the smallest neutrino mass, m{sub 1}=2.5{sup +1.7}{sub -1.6} x 10{sup -3} eV, and one Majorana phase, {alpha}{sub 21}/{pi}=1.0{sup +0.2}{sub -0.2}. (orig.)
'Universality' of the Ablowitz-Ladik hierarchy
International Nuclear Information System (INIS)
Vekslerchik, V.E.
1998-05-01
The aim of this paper is to summarize some recently obtained relations between the Ablowitz-Ladik hierarchy (ALH) and other integrable equations. It has been shown that solutions of finite subsystems of the ALH can be used to derive a wide range of solutions for, e.g., the 2D Toda lattice, nonlinear Schroedinger, Davey-Stewartson, Kadomtsev-Petviashvili (DP) and some other equations. Similar approach has been used to construct new integrable models: O(3,1) and multi field sigma models. Such 'universality' of the ALH becomes more transparent in the framework of the Hirota's bilinear method. The ALH, which is usually considered as an infinite set of differential-difference equations, has been presented as a finite system of functional-difference equations, which can be viewed as a generalization of the famous bilinear identities for the KP tau-functions. (author)
What's Up with the Storage Hierarchy?
DEFF Research Database (Denmark)
Bonnet, Philippe
2017-01-01
Ten years ago, Jim Gray observed that flash was about to replace magnetic disks. He also predicted that the need for low latency would make main memory databases commonplace. Most of his predictions have proven accurate. Today, who can make predictions about the future of the storage hierarchy......? Both main memory and storage systems are undergoing profound transformations. First, their design goals are increasingly complex (reconfigurable infrastructure at low latency, high resource utilization and stable energy footprint). Second, the status quo is not an option due to the shortcomings...... of existing solutions (memory bandwidth gap, inefficiency of generic memory/storage controllers). Third, new technologies are emerging (hybrid memories, non-volatile memories still under non-disclosure agreements, near-data processing in memory and storage). The impact of these transformations on the storage...
Scale-independent inflation and hierarchy generation
Directory of Open Access Journals (Sweden)
Pedro G. Ferreira
2016-12-01
Full Text Available We discuss models involving two scalar fields coupled to classical gravity that satisfy the general criteria: (i the theory has no mass input parameters, (ii classical scale symmetry is broken only through −112ςϕ2R couplings where ς departs from the special conformal value of 1; (iii the Planck mass is dynamically generated by the vacuum expectations values (VEVs of the scalars (iv there is a stage of viable inflation associated with slow roll in the two-scalar potential; (v the final vacuum has a small to vanishing cosmological constant and an hierarchically small ratio of the VEVs and the ratio of the scalar masses to the Planck scale. This assumes the paradigm of classical scale symmetry as a custodial symmetry of large hierarchies.
Structural optimization via a design space hierarchy
Vanderplaats, G. N.
1976-01-01
Mathematical programming techniques provide a general approach to automated structural design. An iterative method is proposed in which design is treated as a hierarchy of subproblems, one being locally constrained and the other being locally unconstrained. It is assumed that the design space is locally convex in the case of good initial designs and that the objective and constraint functions are continuous, with continuous first derivatives. A general design algorithm is outlined for finding a move direction which will decrease the value of the objective function while maintaining a feasible design. The case of one-dimensional search in a two-variable design space is discussed. Possible applications are discussed. A major feature of the proposed algorithm is its application to problems which are inherently ill-conditioned, such as design of structures for optimum geometry.
Dancing Twins: Stellar Hierarchies That Formed Sequentially?
Tokovinin, Andrei
2018-04-01
This paper draws attention to the class of resolved triple stars with moderate ratios of inner and outer periods (possibly in a mean motion resonance) and nearly circular, mutually aligned orbits. Moreover, stars in the inner pair are twins with almost identical masses, while the mass sum of the inner pair is comparable to the mass of the outer component. Such systems could be formed either sequentially (inside-out) by disk fragmentation with subsequent accretion and migration, or by a cascade hierarchical fragmentation of a rotating cloud. Orbits of the outer and inner subsystems are computed or updated in four such hierarchies: LHS 1070 (GJ 2005, periods 77.6 and 17.25 years), HIP 9497 (80 and 14.4 years), HIP 25240 (1200 and 47.0 years), and HIP 78842 (131 and 10.5 years).
Gauge hierarchy, decoupling, and heavy particle effects
International Nuclear Information System (INIS)
Yao, York-Peng
1981-01-01
This chapter examines the problems of a large gauge hierarchy and decoupling in theories with spontaneously broken symmetry. Attempts to show, with regard to all orders in the loop expansion, that: once a proper identification is made of the light particles and of the heavy particles at the tree level, then such a division will be maintained order by order in the loop expansion without the necessity of fine tuning; there is a local renormalizable effective Lagrangian, composed of light fields only, which can be used to reproduce all the one light particle irreducible Green's functions; and a set of renormalization group equations can be written down, wherein one stays in the lower energy region to correlate the two sets of parameters in the full and the effective light theories. The appendix gives an algebraic rearrangement method which can be efficiently used to calculate the muon effects on the electron anomalous magnetic moment
Gauge theories, duality relations and the tensor hierarchy
International Nuclear Information System (INIS)
Bergshoeff, Eric A.; Hohm, Olaf; Hartong, Jelle; Huebscher, Mechthild; OrtIn, Tomas
2009-01-01
We compute the complete 3- and 4-dimensional tensor hierarchies, i.e. sets of p-form fields, with 1 ≤ p ≤ D, which realize an off-shell algebra of bosonic gauge transformations. We show how these tensor hierarchies can be put on-shell by introducing a set of duality relations, thereby introducing additional scalars and a metric tensor. These so-called duality hierarchies encode the equations of motion of the bosonic part of the most general gauged supergravity theories in those dimensions, including the (projected) scalar equations of motion. We construct gauge-invariant actions that include all the fields in the tensor hierarchies. We elucidate the relation between the gauge transformations of the p-form fields in the action and those of the same fields in the tensor hierarchy.
Modelling Dominance Hierarchies Under Winner and Loser Effects.
Kura, Klodeta; Broom, Mark; Kandler, Anne
2015-06-01
Animals that live in groups commonly form themselves into dominance hierarchies which are used to allocate important resources such as access to mating opportunities and food. In this paper, we develop a model of dominance hierarchy formation based upon the concept of winner and loser effects using a simulation-based model and consider the linearity of our hierarchy using existing and new statistical measures. Two models are analysed: when each individual in a group does not know the real ability of their opponents to win a fight and when they can estimate their opponents' ability every time they fight. This estimation may be accurate or fall within an error bound. For both models, we investigate if we can achieve hierarchy linearity, and if so, when it is established. We are particularly interested in the question of how many fights are necessary to establish a dominance hierarchy.
A study on the hierarchy model of nuclear reactions
International Nuclear Information System (INIS)
Kitazoe, Yasuhiro; Sekiya, Tamotsu
1975-01-01
The application of the hierarchy model of nuclear reaction is discussed, and the hierarchy model means that the compound nucleus state is formed after several steps, at least, one step of reaction. This model was applied to the analysis of the observed cross sections of 235 U and some other elements. Neglecting exchange scattering effect, the equations for the total neutron cross section of 235 U were obtained. One of these equations describes explicitly the hierarchy of the transition from intermediate reaction state Xm into the compound nucleus state Xs, and another one describes the cross section averaged over an energy interval larger than the average level spacing of compound nucleus eigenvalues. The hierarchy of reaction mechanism was investigated in more detail, and the hierarchy model was applied to the case of unresolved energy region. It was not tried to evaluate the strength function in the mass region (A>140), since the effect of nuclear deformation was neglected in the task. (Iwase, T.)
The Impact of Formal Hierarchies on Enterprise Social Networking Behavior
DEFF Research Database (Denmark)
Behrendt, Sebastian; Klier, Julia; Klier, Mathias
2015-01-01
With more and more companies using enterprise social networks (ESN) for employee communication and collaboration, the influence of ESN on organizational hierarchies has been subject of countless discussions in practice-oriented media and first academic studies. Conversely, the question whether...... and how formal organizational hierarchies influence ESN usage behavior has not yet been addressed. Drawing on a rich data set comprising 2.5 years of relationship building via direct messages, confirmed contact requests, and group messages, we are able to show that formal hierarchies have an important...... impact on social networking behavior. By applying means of social network analysis and supported by statements from interviews, we illustrate how deeply formal hierarchy impacts the three examined types of relationships. Our results motivate academics to further study the interrelation between hierarchy...
A Hierarchy of Homodesmotic Reactions for Thermochemistry
Schleyer, Paul v. R.
2009-01-01
Chemical equations that balance bond types and atom hybridization to different degrees are often used in computational thermochemistry, for example, to increase accuracy when lower levels of theory are employed. We expose the widespread confusion over such classes of equations and demonstrate that the two most widely used definitions of “homodesmotic” reactions are not equivalent. New definitions are introduced and a consistent hierarchy of reaction classes (RC1 – RC5) for hydrocarbons is constructed: isogyric (RC1) ⊇ isodesmic (RC2) ⊇ hypohomodesmotic (RC3) ⊇ homodesmotic (RC4) ⊇ hyperhomodesmotic (RC5). Each of these successively conserves larger molecular fragments. The concept of isodesmic bond separation reactions is generalized to all classes in this hierarchy, providing a unique sectioning of a given molecule for each reaction type. Several ab initio and density functional methods are applied to the bond separation reactions of 38 hydrocarbons containing five or six carbon atoms. RC4 and RC5 reactions provide bond separation enthalpies with errors consistently less than 0.4 kcal mol−1 across a wide range of theoretical levels, performing significantly better than the other reaction types and far superior to atomization routes. Our recommended bond separation reactions were demonstrated by determining the enthalpies of formation (at 298 K) of 1,3,5-hexatriyne (163.7 ± 0.4 kcal mol−1), 1,3,5,7-octatetrayne (217.6 ± 0.6 kcal mol−1), the larger polyynes C10H2 through C26H2, and an infinite acetylenic carbon chain. PMID:19182999
The dynamic nature of social hierarchies : The role of norm violations and hierarchical concerns
Stamkou, E.
2018-01-01
Social hierarchy is a fundamental feature of social relations. Hierarchies are appealing psychologically because they facilitate group functioning, which explains why they tend to be reinforced and perpetuated. Hierarchies, however, can also become unstable and eventually undergo change because
Zwaan, Michiel; Dijkstra, Jan Kornelis; Veenstra, Rene
2013-01-01
The moderating effects of three specific conditions (status hierarchy, attractiveness hierarchy and sex ratio) on the link between status (popularity) and physical and relational aggression were examined in a large sample of adolescent boys ("N" = 1,665) and girls ("N" = 1,637) ("M" age = 13.60). In line with the…
Zwaan, Michiel; Dijkstra, Jan; Veenstra, René
The moderating effects of three specific conditions (status hierarchy, attractiveness hierarchy and sex ratio) on the link between status (popularity) and physical and relational aggression were examined in a large sample of adolescent boys (N = 1,665) and girls (N = 1,637) (M age = 13.60). In line
Symmetries of supersymmetric integrable hierarchies of KP type
International Nuclear Information System (INIS)
Nissimov, E.; Pacheva, S.
2002-01-01
This article is devoted to the systematic study of additional (non-isospectral) symmetries of constrained (reduced) supersymmetric integrable hierarchies of KP type--the so-called SKP (R;M B ,M F ) models. The latter are supersymmetric extensions of ordinary constrained KP hierarchies which contain as special cases basic integrable systems such as (m)KdV, AKNS, Fordy-Kulish, Yajima-Oikawa, etc. As a first main result it is shown that any SKP (R;M B ,M F ) hierarchy possesses two different mutually (anti-)commuting types of superloop superalgebra additional symmetries corresponding to the positive- and negative-grade parts of certain superloop superalgebras. The second main result is the systematic construction of the full algebra of additional Virasoro symmetries of SKP (R;M B ,M F ) hierarchies, which requires nontrivial modifications of the Virasoro flows known from the general case of unconstrained Manin-Radul super-KP hierarchies (the latter flows do not define symmetries for constrained SKP (R;M B ,M F ) hierarchies). As a third main result we provide systematic construction of the supersymmetric analogs of multi-component (matrix) KP hierarchies and show that the latter contain, among others, the supersymmetric version of the Davey-Stewartson system. Finally, we present an explicit derivation of the general Darboux-Baecklund solutions for the SKP (R;M B ,M F ) super-tau functions (supersymmetric 'soliton'-like solutions) which preserve the additional (non-isospectral) symmetries
Wavelet Correlation Coefficient of 'strongly correlated' financial time series
Razdan, Ashok
2003-01-01
In this paper we use wavelet concepts to show that correlation coefficient between two financial data's is not constant but varies with scale from high correlation value to strongly anti-correlation value This studies is important because correlation coefficient is used to quantify degree of independence between two variables. In econophysics correlation coefficient forms important input to evolve hierarchial tree and minimum spanning tree of financial data.
Topological hierarchy matters — topological matters with superlattices of defects
International Nuclear Information System (INIS)
He Jing; Kou Su-Peng
2016-01-01
Topological insulators/superconductors are new states of quantum matter with metallic edge/surface states. In this paper, we review the defects effect in these topological states and study new types of topological matters — topological hierarchy matters. We find that both topological defects (quantized vortices) and non topological defects (vacancies) can induce topological mid-gap states in the topological hierarchy matters after considering the superlattice of defects. These topological mid-gap states have nontrivial topological properties, including the nonzero Chern number and the gapless edge states. Effective tight-binding models are obtained to describe the topological mid-gap states in the topological hierarchy matters. (topical review)
Decomposition of a hierarchy of nonlinear evolution equations
International Nuclear Information System (INIS)
Geng Xianguo
2003-01-01
The generalized Hamiltonian structures for a hierarchy of nonlinear evolution equations are established with the aid of the trace identity. Using the nonlinearization approach, the hierarchy of nonlinear evolution equations is decomposed into a class of new finite-dimensional Hamiltonian systems. The generating function of integrals and their generator are presented, based on which the finite-dimensional Hamiltonian systems are proved to be completely integrable in the Liouville sense. As an application, solutions for the hierarchy of nonlinear evolution equations are reduced to solving the compatible Hamiltonian systems of ordinary differential equations
Testing strong interaction theories
International Nuclear Information System (INIS)
Ellis, J.
1979-01-01
The author discusses possible tests of the current theories of the strong interaction, in particular, quantum chromodynamics. High energy e + e - interactions should provide an excellent means of studying the strong force. (W.D.L.)
Kinetic mixing and the supersymmetric gauge hierarchy
International Nuclear Information System (INIS)
Dienes, K.R.; Kolda, C.; March-Russell, J.
1997-01-01
The most general Lagrangian for a model with two U(1) gauge symmetries contains a renormalizable operator which mixes their gauge kinetic terms. Such kinetic mixing can be generated at arbitrarily high scales but will not be suppressed by large masses. In models whose supersymmetry (SUSY)-breaking hidden sectors contain U(1) gauge factors, we show that such terms will generically arise and communicate SUSY breaking to the visible sector through mixing with hypercharge. In the context of the usual supergravity- or gauge-mediated communication scenarios with D-terms of order the fundamental scale of SUSY breaking, this effect can destabilize the gauge hierarchy. Even in models for which kinetic mixing is suppressed or the D-terms are arranged to be small, this effect is a potentially large correction to the soft scalar masses and therefore introduces a new measurable low-energy parameter. We calculate the size of kinetic mixing both in field theory and in string theory, and argue that appreciable kinetic mixing is a generic feature of string models. We conclude that the possibility of kinetic mixing effects cannot be ignored in model building and in phenomenological studies of the low-energy SUSY spectra. (orig.)
Hierarchy Formation and Self-Determination
Directory of Open Access Journals (Sweden)
Stefano I. Di Domenico
2014-12-01
Full Text Available We examined how self-determination, the subjective experience of one’s behavior as internally initiated and personally endorsed, depends on one’s standing in real-world social hierarchies. We predicted that those with the traits most relevant to status attainment would be those afforded the most opportunities to be self-determining. We examined the trait of physical attractiveness, given its documented association with social status and no known association with self-determination. First-year undergraduates living in same-sex residences rated their housemates’ social status, while an independent set of observers rated the participants’ physical attractiveness. Consistent with prediction, physically attractive individuals attained the highest levels of social status; in turn, those who attained the highest levels of social status experienced the highest levels of self-determination. These findings provide new insights into self-determination as an inherently relational phenomenon and specifically highlight the formative influence of social status on people’s capacities for self-determination.
Metadata Life Cycles, Use Cases and Hierarchies
Directory of Open Access Journals (Sweden)
Ted Habermann
2018-05-01
Full Text Available The historic view of metadata as “data about data” is expanding to include data about other items that must be created, used, and understood throughout the data and project life cycles. In this context, metadata might better be defined as the structured and standard part of documentation, and the metadata life cycle can be described as the metadata content that is required for documentation in each phase of the project and data life cycles. This incremental approach to metadata creation is similar to the spiral model used in software development. Each phase also has distinct users and specific questions to which they need answers. In many cases, the metadata life cycle involves hierarchies where latter phases have increased numbers of items. The relationships between metadata in different phases can be captured through structure in the metadata standard, or through conventions for identifiers. Metadata creation and management can be streamlined and simplified by re-using metadata across many records. Many of these ideas have been developed to various degrees in several Geoscience disciplines and are being used in metadata for documenting the integrated life cycle of environmental research in the Arctic, including projects, collection sites, and datasets.
Signaling hierarchy regulating human endothelial cell development.
Kelly, Melissa A; Hirschi, Karen K
2009-05-01
Our present knowledge of the regulation of mammalian endothelial cell differentiation has been largely derived from studies of mouse embryonic development. However, unique mechanisms and hierarchy of signals that govern human endothelial cell development are unknown and, thus, explored in these studies. Using human embryonic stem cells as a model system, we were able to reproducibly and robustly generate differentiated endothelial cells via coculture on OP9 marrow stromal cells. We found that, in contrast to studies in the mouse, bFGF and VEGF had no specific effects on the initiation of human vasculogenesis. However, exogenous Ihh promoted endothelial cell differentiation, as evidenced by increased production of cells with cobblestone morphology that coexpress multiple endothelial-specific genes and proteins, form lumens, and exhibit DiI-AcLDL uptake. Inhibition of BMP signaling using Noggin or BMP4, specifically, using neutralizing antibodies suppressed endothelial cell formation; whereas, addition of rhBMP4 to cells treated with the hedgehog inhibitor cyclopamine rescued endothelial cell development. Our studies revealed that Ihh promoted human endothelial cell differentiation from pluripotent hES cells via BMP signaling, providing novel insights applicable to modulating human endothelial cell formation and vascular regeneration for human clinical therapies.
The Basis of the Syllable Hierarchy: Articulatory Pressures or Universal Phonological Constraints?
Zhao, Xu; Berent, Iris
2018-02-01
Across languages, certain syllable types are systematically preferred to others (e.g., [Formula: see text] lbif, where [Formula: see text] indicates a preference). Previous research has shown that these preferences are active in the brains of individual speakers, they are evident even when none of these syllable types exists in participants' language, and even when the stimuli are presented in print. These results suggest that the syllable hierarchy cannot be reduced to either lexical or auditory/phonetic pressures. Here, we examine whether the syllable hierarchy is due to articulatory pressures. According to the motor embodiment view, the perception of a linguistic stimulus requires simulating its production; dispreferred syllables (e.g., lbif) are universally disliked because their production is harder to simulate. To address this possibility, we assessed syllable preferences while articulation was mechanically suppressed. Our four experiments each found significant effects of suppression. Remarkably, people remained sensitive to the syllable hierarchy regardless of suppression. Specifically, results with auditory materials (Experiments 1-2) showed strong effects of syllable structure irrespective of suppression. Moreover, syllable structure uniquely accounted for listeners' behavior even when controlling for several phonetic characteristics of our auditory materials. Results with printed stimuli (Experiments 3-4) were more complex, as participants in these experiments relied on both phonological and graphemic information. Nonetheless, readers were sensitive to most of the syllable hierarchy (e.g., [Formula: see text]), and these preferences emerged when articulation was suppressed, and even when the statistical properties of our materials were controlled via a regression analysis. Together, these findings indicate that speakers possess broad grammatical preferences that are irreducible to either sensory or motor factors.
Optimal mesh hierarchies in Multilevel Monte Carlo methods
Von Schwerin, Erik
2016-01-08
I will discuss how to choose optimal mesh hierarchies in Multilevel Monte Carlo (MLMC) simulations when computing the expected value of a quantity of interest depending on the solution of, for example, an Ito stochastic differential equation or a partial differential equation with stochastic data. I will consider numerical schemes based on uniform discretization methods with general approximation orders and computational costs. I will compare optimized geometric and non-geometric hierarchies and discuss how enforcing some domain constraints on parameters of MLMC hierarchies affects the optimality of these hierarchies. I will also discuss the optimal tolerance splitting between the bias and the statistical error contributions and its asymptotic behavior. This talk presents joint work with N.Collier, A.-L.Haji-Ali, F. Nobile, and R. Tempone.
Flexible scheme to truncate the hierarchy of pure states.
Zhang, P-P; Bentley, C D B; Eisfeld, A
2018-04-07
The hierarchy of pure states (HOPS) is a wavefunction-based method that can be used for numerically modeling open quantum systems. Formally, HOPS recovers the exact system dynamics for an infinite depth of the hierarchy. However, truncation of the hierarchy is required to numerically implement HOPS. We want to choose a "good" truncation method, where by "good" we mean that it is numerically feasible to check convergence of the results. For the truncation approximation used in previous applications of HOPS, convergence checks are numerically challenging. In this work, we demonstrate the application of the "n-particle approximation" to HOPS. We also introduce a new approximation, which we call the "n-mode approximation." We then explore the convergence of these truncation approximations with respect to the number of equations required in the hierarchy in two exemplary problems: absorption and energy transfer of molecular aggregates.
Assessing the hierarchy of needs in levels of service
2005-10-01
The primary focus of this research project was in providing empirical evidence of a Hierarchy of Transportation : Needs. The experimental procedure, methodology, and materials for this project were designed using both : transportation stated preferen...
A generalized AKNS hierarchy and its bi-Hamiltonian structures
International Nuclear Information System (INIS)
Xia Tiecheng; You Fucai; Chen Dengyuan
2005-01-01
First we construct a new isospectral problem with 8 potentials in the present paper. And then a new Lax pair is presented. By making use of Tu scheme, a class of new soliton hierarchy of equations is derived, which is integrable in the sense of Liouville and possesses bi-Hamiltonian structures. After making some reductions, the well-known AKNS hierarchy and other hierarchies of evolution equations are obtained. Finally, in order to illustrate that soliton hierarchy obtained in the paper possesses bi-Hamiltonian structures exactly, we prove that the linear combination of two-Hamiltonian operators admitted are also a Hamiltonian operator constantly. We point out that two Hamiltonian operators obtained of the system are directly derived from a recurrence relations, not from a recurrence operator
Two-reduction of the super-KP hierarchy
International Nuclear Information System (INIS)
McArthur, I.N.
1994-01-01
Recursion relations are established for the residues of fractional powers of a two-reduced super-KP operator making use of the Baker-Akhiezer function. These show the integrability of the two-reduced even (or bosonic) flows of the super-KP hierarchy. Similar recursion relations are also proven for the residues of operators associated with the odd (or fermionic) flows of the Mulase-Rabin super-KP hierarchy. Due to the presence of a spectral parameter and itts fermionic partner in the Baker-Akhiezer function, these recursion relations should be relevant to any attempt to prove or disprove a recent proposal that the integrable hierarchy underlying two-dimensional quantum supergravity is the Mulase-Rabin super-KP hierarchy. (orig.)
On natural hierarchy in dynamically broken gauge models
International Nuclear Information System (INIS)
Frere, J.M.
1980-01-01
A model based on dynamical symmetry breaking provides a naturally large 'mass hierarchy'. Few fermions are needed at intermediate energies, and asymptotic freedom of usual interactions is therefore not imperiled. (orig.)
Neutrino mass hierarchy determination for θ13 = 0
International Nuclear Information System (INIS)
Gandhi, Raj; Ghoshal, Pomita; Goswami, Srubabati; Sankar, S. Uma
2010-01-01
We examine the possibility of determining the neutrino mass hierarchy in the limit θ 13 = 0 using atmospheric neutrinos as the source. In this limit, θ 13 driven matter effects are absent so independent measurements of Δ 31 and Δ 32 can, in principle, lead to hierarchy determination. Since their difference is Δ 21 , one needs an experimental arrangement where Δ 21 L/E > or approx. 1 can be achieved. This can be satisfied by atmospheric neutrinos which have a large range of L and E. Still, we find that hierarchy determination in the θ 13 = 0 limit with atmospheric neutrinos is not a realistic possibility, even in conjunction with a beam experiment like T2K or NOνA. We discuss why, and also reiterate the general conditions for hierarchy determination if θ 13 = 0.
Variable-coefficient nonisospectral Toda lattice hierarchy and its ...
Indian Academy of Sciences (India)
In this paper, a hierarchy of nonisospectral equations with variable coefficients is derived from the ..... from the definitions of Lax integrability and Lax pairs [26] that the variable-coefficient ..... studying which will be the topic for our future study.
Optimal mesh hierarchies in Multilevel Monte Carlo methods
Von Schwerin, Erik
2016-01-01
I will discuss how to choose optimal mesh hierarchies in Multilevel Monte Carlo (MLMC) simulations when computing the expected value of a quantity of interest depending on the solution of, for example, an Ito stochastic differential equation or a partial differential equation with stochastic data. I will consider numerical schemes based on uniform discretization methods with general approximation orders and computational costs. I will compare optimized geometric and non-geometric hierarchies and discuss how enforcing some domain constraints on parameters of MLMC hierarchies affects the optimality of these hierarchies. I will also discuss the optimal tolerance splitting between the bias and the statistical error contributions and its asymptotic behavior. This talk presents joint work with N.Collier, A.-L.Haji-Ali, F. Nobile, and R. Tempone.
On the origins of hierarchy in complex networks
Corominas-Murtra, Bernat; Goñi, Joaquín; Solé, Ricard V.; Rodríguez-Caso, Carlos
2013-01-01
Hierarchy seems to pervade complexity in both living and artificial systems. Despite its relevance, no general theory that captures all features of hierarchy and its origins has been proposed yet. Here we present a formal approach resulting from the convergence of theoretical morphology and network theory that allows constructing a 3D morphospace of hierarchies and hence comparing the hierarchical organization of ecological, cellular, technological, and social networks. Embedded within large voids in the morphospace of all possible hierarchies, four major groups are identified. Two of them match the expected from random networks with similar connectivity, thus suggesting that nonadaptive factors are at work. Ecological and gene networks define the other two, indicating that their topological order is the result of functional constraints. These results are consistent with an exploration of the morphospace, using in silico evolved networks. PMID:23898177
Flexible scheme to truncate the hierarchy of pure states
Zhang, P.-P.; Bentley, C. D. B.; Eisfeld, A.
2018-04-01
The hierarchy of pure states (HOPS) is a wavefunction-based method that can be used for numerically modeling open quantum systems. Formally, HOPS recovers the exact system dynamics for an infinite depth of the hierarchy. However, truncation of the hierarchy is required to numerically implement HOPS. We want to choose a "good" truncation method, where by "good" we mean that it is numerically feasible to check convergence of the results. For the truncation approximation used in previous applications of HOPS, convergence checks are numerically challenging. In this work, we demonstrate the application of the "n-particle approximation" to HOPS. We also introduce a new approximation, which we call the "n-mode approximation." We then explore the convergence of these truncation approximations with respect to the number of equations required in the hierarchy in two exemplary problems: absorption and energy transfer of molecular aggregates.
Plasticity within stem cell hierarchies in mammalian epithelia.
Tetteh, Paul W; Farin, Henner F; Clevers, Hans
2015-02-01
Tissue homeostasis and regeneration are fueled by resident stem cells that have the capacity to self-renew, and to generate all the differentiated cell types that characterize a particular tissue. Classical models of such cellular hierarchies propose that commitment and differentiation occur unidirectionally, with the arrows 'pointing away' from the stem cell. Recent studies, all based on genetic lineage tracing, describe various strategies employed by epithelial stem cell hierarchies to replace damaged or lost cells. While transdifferentiation from one tissue type into another ('metaplasia') appears to be generally forbidden in nonpathological contexts, plasticity within an individual tissue stem cell hierarchy may be much more common than previously appreciated. In this review, we discuss recent examples of such plasticity in selected mammalian epithelia, highlighting the different modes of regeneration and their implications for our understanding of cellular hierarchy and tissue self-renewal. Copyright © 2014 Elsevier Ltd. All rights reserved.
Maslow's Implied Matrix: A Clarification of the Need Hierarchy Theory.
Marsh, Edward
1978-01-01
Maslow's need hierarchy theory is restated by means of a matrix arrangement of the constructs within the theory. After consideration of the consequences of this restatement, some significant research is discussed and directions for future research suggested. (Author)
Effects of neutrino oscillation on supernova neutrino. Inverted mass hierarchy
International Nuclear Information System (INIS)
Takahashi, Keitaro; Sato, Katsuhiko
2003-01-01
We study the effects of neutrino oscillation on supernova neutrinos in the case of the inverted mass hierarchy (m 3 1 2 ) as well as the normal mass hierarchy (m 1 2 3 ). Numerical analysis using realistic supernova and presupernova models allows us to investigate quantitatively the possibility to probe neutrino oscillation parameters. We show that information about the mass hierarchy can be obtained if θ 13 is rather large (sin 2 2θ 13 > 10 -3 ) and that θ 13 can be probed effectively by SuperKamiokande if the neutrino mass hierarchy is inverted. Errors due to the uncertainty in the original neutrino spectra and the Earth effect are also discussed. (author)
The influence of migration on gender hierarchies within the African ...
African Journals Online (AJOL)
The influence of migration on gender hierarchies within the African household. ... activities and headship-related roles both within the private and public domains. ... conducted among African women from both formal and informal sectors, this ...
DEFF Research Database (Denmark)
Riedl, Petra; Wieland, Andreas; Lamberth, Kasper
2009-01-01
Immunodominance limits the TCR diversity of specific antiviral CD8 T cell responses elicited by vaccination or infection. To prime multispecific T cell responses, we constructed DNA vaccines that coexpress chimeric, multidomain Ags (with CD8 T cell-defined epitopes of the hepatitis B virus (HBV...... cell immunity by multidomain Ags. The "weak" (i.e., easily suppressed) K(b)/C(93-100)-specific CD8 T cell response was efficiently elicited by a HBV core Ag-encoding vector in 1.4HBV-S(mut) tg mice (that harbor a replicating HBV genome that produces HBV surface, core, and precore Ag in the liver). K......(b)/C(93-100)-specific CD8 T cells accumulated in the liver of vaccinated 1.4HBV-S(mut) transgenic mice where they suppressed HBV replication. Subdominant epitopes in vaccines can hence prime specific CD8 T cell immunity in a tolerogenic milieu that delivers specific antiviral effects to HBV...
Directory of Open Access Journals (Sweden)
Carlos A. Alba-Fierro
2016-01-01
Full Text Available Cell wall (CW components of fungus Sporothrix schenckii are the major inductors antigens of immune responses. The immunodominant 60 kDa glycoprotein (gp60 has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown. In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S. schenckii conidia. Results showed that both mice strains use different cytokine profiles in order to fight S. schenckii infection; C57BL/6 mice seem to use a Th17 response while BALB/c mice tend to depend on a Th1 profile. Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains. There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains. However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB/c than in C57BL/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.
Alba-Fierro, Carlos A; Pérez-Torres, Armando; Toriello, Conchita; Pulido-Camarillo, Evelyn; López-Romero, Everardo; Romo-Lozano, Yolanda; Gutiérrez-Sánchez, Gerardo; Ruiz-Baca, Estela
2016-01-01
Cell wall (CW) components of fungus Sporothrix schenckii are the major inductors antigens of immune responses. The immunodominant 60 kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown. In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S. schenckii conidia. Results showed that both mice strains use different cytokine profiles in order to fight S. schenckii infection; C57BL/6 mice seem to use a Th17 response while BALB/c mice tend to depend on a Th1 profile. Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains. There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains. However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB/c than in C57BL/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.
International Nuclear Information System (INIS)
Chu, Fuliang; Lou, Zhiyong; Gao, Bin; Bell, John I.; Rao, Zihe; Gao, George F.
2005-01-01
Crystallization of the first rhesus macaque MHC class I complex. Simian immunodeficiency virus (SIV) infection in rhesus macaques has been used as the best model for the study of human immunodeficiency virus (HIV) infection in humans, especially in the cytotoxic T-lymphocyte (CTL) response. However, the structure of rhesus macaque (or any other monkey model) major histocompatibility complex class I (MHC I) presenting a specific peptide (the ligand for CTL) has not yet been elucidated. Here, using in vitro refolding, the preparation of the complex of the rhesus macaque MHC I allele (Mamu-A*01) with human β 2 m and an immunodominant peptide, CTPYDINQM (Gag-CM9), derived from SIV Gag protein is reported. The complex (45 kDa) was crystallized; the crystal belongs to space group I422, with unit-cell parameters a = b = 183.8, c = 155.2 Å. The crystal contains two molecules in the asymmetric unit and diffracts X-rays to 2.8 Å resolution. The structure is being solved by molecular replacement and this is the first attempt to determined the crystal structure of a peptide–nonhuman primate MHC complex
Slutzky, G M; Greenblatt, C L
1982-01-01
Inhibition by low-molecular-weight sugars of precipitin line formation between a polysaccharide (EF) excreted by Leishmania tropica subsp. major, Leishmania enriettii, and rabbit antileishmanial antibodies on double gel diffusion plates revealed that galactose residues, possibly as components of lactosyl groups, were the critical immunodominant sugars mediating antibody recognition of EF. The galactose residues of the EF of L. tropica subsp. major were specifically labeled with tritium via galactose oxidase and sodium boro[3H]hydride. The radioactive EF had an apparent molecular weight of about 85,000 on sodium dodecyl sulfate-polyacrylamide gels and was precipitated by antileishmanial antibodies as well as Ricinus communis lectins I and II (galactose specific). Lectins specific for glucose-mannose residues, fucose, N-acetylglucosamine, and N-acetylgalactosamine did not precipitate the labeled EF. Treatment of [3H]EF with proteolytic (trypsin, papain, protease) or glycosidic (alpha-amylase, beta-galactosidase) enzymes had no effect on either the electrophoretic pattern of the material or on its recognition by antileishmanial antibodies or R. communis lectin. This resistance to enzyme activity suggests that EF may be a useful marker for the presence of the parasite in vivo if it can be detected in minute quantities. PMID:6179874
International Nuclear Information System (INIS)
Plotnicky, H.; Cyblat-Chanal, D.; Aubry, J.-P.; Derouet, F.; Klinguer-Hamour, C.; Beck, A.; Bonnefoy, J.-Y.; Corvaiea, N.
2003-01-01
The protective efficacy of the influenza matrix protein epitope 58-66 (called M1), recognized in the context of human HLA-A2 molecules, was evaluated in a HLA-A2/K b transgenic mouse model of lethal influenza infection. Repeated subcutaneous immunizations with M1 increased the percentage of survival. This effect was mediated by T cells since protection was abolished following in vivo depletion of all T lymphocytes, CD8 + , or CD4 + T cells. The survival correlated with the detection of memory CD8 + splenocytes able to proliferate in vitro upon stimulation with M1 and to bind M1-loaded HLA-A2 dimers, as well as with M1-specific T cells in the lungs, which were directly cytotoxic to influenza-infected cells following influenza challenge. These results demonstrated for the first time that HLA-A2-restricted cytotoxic T cells specific for the major immunodominant influenza matrix epitope are protective against the infection. They encourage further in vivo evaluation of T cell epitopes recognized in the context of human MHC molecules
An Improved Semidefinite Programming Hierarchy for Testing Entanglement
Harrow, Aram W.; Natarajan, Anand; Wu, Xiaodi
2017-06-01
We present a stronger version of the Doherty-Parrilo-Spedalieri (DPS) hierarchy of approximations for the set of separable states. Unlike DPS, our hierarchy converges exactly at a finite number of rounds for any fixed input dimension. This yields an algorithm for separability testing that is singly exponential in dimension and polylogarithmic in accuracy. Our analysis makes use of tools from algebraic geometry, but our algorithm is elementary and differs from DPS only by one simple additional collection of constraints.
Social Hierarchy and Depression: The Role of Emotion Suppression
Langner, Carrie A.; Epel, Elissa; Matthews, Karen; Moskowitz, Judith T.; Adler, Nancy
2012-01-01
Position in the social hierarchy is a major determinant of health outcomes. We examined the associations between aspects of social hierarchy and depressive symptoms with a specific focus on one potential psychological mechanism: emotion suppression. Suppressing negative emotion has mental health costs, but individuals with low social power and low social status may use these strategies to avoid conflict. Study 1 assessed perceived social power, tendency to suppress negative emotion, and depre...
Quasiclassical deformation in KP hierarchy and Benney's long wave equations
International Nuclear Information System (INIS)
Kolokol'tsov, V.N.; Lebedev, D.R.
1987-01-01
In the paper by means of the formal variant of Zakharov-Shabat ''dressing'' method various formulas are obtained for the generating functions of the conservation laws of Kadomtsev-Petvias hierarchy which turn into analogous formulas for Benney hierarchy in the quasiclassical limit. The generating fucntion of the conservation laws of Miura type is constructed for higher Benney equations and the simple proof of the related identities is given
Reactions to Crime as a Hierarchy Regulating Strategy:
DEFF Research Database (Denmark)
Green, Eva G. T.; Thomsen, Lotte; Sidanius, Jim
2009-01-01
Across two studies, we demonstrated that support for group-based hierarchies differentially affects evaluation of ingroup and outgroup criminal offenders and that this effect generalizes to overall evaluations of their respective groups. Drawing on social dominance theory, our results show that d...... of ethnicity or nationality, not education level and employment status, were the important cues for hierarchy-regulating judgments of criminal offenders...
Standard model fermion hierarchies with multiple Higgs doublets
International Nuclear Information System (INIS)
Solaguren-Beascoa Negre, Ana
2016-01-01
The hierarchies between the Standard Model (SM) fermion masses and mixing angles and the origin of neutrino masses are two of the biggest mysteries in particle physics. We extend the SM with new Higgs doublets to solve these issues. The lightest fermion masses and the mixing angles are generated through radiative effects, correctly reproducing the hierarchy pattern. Neutrino masses are generated in the see-saw mechanism.
Earth Effects and Mass Hierarchy with Supernova Neutrinos
International Nuclear Information System (INIS)
Dasgupta, Basudeb
2009-01-01
Collective neutrino flavor transformations take place deep inside a supernova if the neutrino mass hierarchy is inverted, even for extremely small values of θ 13 . We show that the presence (or absence) of Earth matter effects in antineutrino signal is directly related to the absence (or presence) of these collective effects, when the mixing angle θ 13 is small. Thus a neutrino signal from a galactic supernova may enable us to distinguish between the hierarchies even for small values of θ 13 .
Conformal fields. From Riemann surfaces to integrable hierarchies
International Nuclear Information System (INIS)
Semikhatov, A.M.
1991-01-01
I discuss the idea of translating ingredients of conformal field theory into the language of hierarchies of integrable differential equations. Primary conformal fields are mapped into (differential or matrix) operators living on the phase space of the hierarchy, whereas operator insertions of, e.g., a current or the energy-momentum tensor, become certain vector fields on the phase space and thus acquire a meaning independent of a given Riemann surface. A number of similarities are observed between the structures arising on the hierarchy and those of the theory on the world-sheet. In particular, there is an analogue of the operator product algebra with the Cauchy kernel replaced by its 'off-shell' hierarchy version. Also, hierarchy analogues of certain operator insertions admit two (equivalent, but distinct) forms, resembling the 'bosonized' and 'fermionized' versions respectively. As an application, I obtain a useful reformulation of the Virasoro constraints of the type that arise in matrix models, as a system of equations on dressing (or Lax) operators (rather than correlation functions, i.e., residues or traces). This also suggests an interpretation in terms of a 2D topological field theory, which might be extended to a correspondence between Virasoro-constrained hierarchies and topological theories. (orig.)
Inequality matters: classroom status hierarchy and adolescents' bullying.
Garandeau, Claire F; Lee, Ihno A; Salmivalli, Christina
2014-07-01
The natural emergence of status hierarchies in adolescent peer groups has long been assumed to help prevent future intragroup aggression. However, clear evidence of this beneficial influence is lacking. In fact, few studies have examined between-group differences in the degree of status hierarchy (defined as within-group variation in individual status) and how they are related to bullying, a widespread form of aggression in schools. Data from 11,296 eighth- and ninth-graders (mean age = 14.57, 50.6 % female) from 583 classes in 71 schools were used to determine the direction of the association between classroom degree of status hierarchy and bullying behaviors, and to investigate prospective relationships between these two variables over a 6-month period. Multilevel structural equation modeling analyses showed that higher levels of classroom status hierarchy were concurrently associated with higher levels of bullying at the end of the school year. Higher hierarchy in the middle of the school year predicted higher bullying later in the year. No evidence was found to indicate that initial bullying predicted future hierarchy. These findings highlight the importance of a shared balance of power in the classroom for the prevention of bullying among adolescents.
A Bayesian Sampler for Optimization of Protein Domain Hierarchies
2014-01-01
Abstract The process of identifying and modeling functionally divergent subgroups for a specific protein domain class and arranging these subgroups hierarchically has, thus far, largely been done via manual curation. How to accomplish this automatically and optimally is an unsolved statistical and algorithmic problem that is addressed here via Markov chain Monte Carlo sampling. Taking as input a (typically very large) multiple-sequence alignment, the sampler creates and optimizes a hierarchy by adding and deleting leaf nodes, by moving nodes and subtrees up and down the hierarchy, by inserting or deleting internal nodes, and by redefining the sequences and conserved patterns associated with each node. All such operations are based on a probability distribution that models the conserved and divergent patterns defining each subgroup. When we view these patterns as sequence determinants of protein function, each node or subtree in such a hierarchy corresponds to a subgroup of sequences with similar biological properties. The sampler can be applied either de novo or to an existing hierarchy. When applied to 60 protein domains from multiple starting points in this way, it converged on similar solutions with nearly identical log-likelihood ratio scores, suggesting that it typically finds the optimal peak in the posterior probability distribution. Similarities and differences between independently generated, nearly optimal hierarchies for a given domain help distinguish robust from statistically uncertain features. Thus, a future application of the sampler is to provide confidence measures for various features of a domain hierarchy. PMID:24494927
Reappraising the functional implications of the primate visual anatomical hierarchy.
Hegdé, Jay; Felleman, Daniel J
2007-10-01
The primate visual system has been shown to be organized into an anatomical hierarchy by the application of a few principled criteria. It has been widely assumed that cortical visual processing is also hierarchical, with the anatomical hierarchy providing a defined substrate for clear levels of hierarchical function. A large body of empirical evidence seemed to support this assumption, including the general observations that functional properties of visual neurons grow progressively more complex at progressively higher levels of the anatomical hierarchy. However, a growing body of evidence, including recent direct experimental comparisons of functional properties at two or more levels of the anatomical hierarchy, indicates that visual processing neither is hierarchical nor parallels the anatomical hierarchy. Recent results also indicate that some of the pathways of visual information flow are not hierarchical, so that the anatomical hierarchy cannot be taken as a strict flowchart of visual information either. Thus, while the sustaining strength of the notion of hierarchical processing may be that it is rather simple, its fatal flaw is that it is overly simplistic.
Two hierarchies of multi-component Kaup-Newell equations and theirs integrable couplings
International Nuclear Information System (INIS)
Zhu Fubo; Ji Jie; Zhang Jianbin
2008-01-01
Two hierarchies of multi-component Kaup-Newell equations are derived from an arbitrary order matrix spectral problem, including positive non-isospectral Kaup-Newell hierarchy and negative non-isospectral Kaup-Newell hierarchy. Moreover, new integrable couplings of the resulting Kaup-Newell soliton hierarchies are constructed by enlarging the associated matrix spectral problem
N = 4 super KdV hierarchy in N = 4 and N = 2 superspaces
International Nuclear Information System (INIS)
Delduc, F.
1995-10-01
The results of further analysis of the integrability properties of the N = 4 supersymmetric KdV equation deduced earlier as a Hamiltonian flow on N 4 SU(2) superconformal algebra in the harmonic N = 4 superspace are presented. To make this equation and the relevant Hamiltonian structures more tractable, it is reformulated in the ordinary N = 4 and further in N = 2 superspaces. These results provide a strong evidence that the unique N = 4 SU(2) super KdV hierarchy exists. (author)
Fighting for resources: Two leaders in the money addicted social hierarchies
Dybiec, Bartłomiej
Building of hierarchy is inevitably associated with the constant competition for resources and attention. Here, we show how presence of two favored (leading) nodes affects properties of the network connecting individuals. In particular, we study how nodes characteristics depend on relative asymmetry between two leading nodes. It is shown that without strong and rigorous avoidance mechanism, individuals can support both dominating nodes. Slow redistribution of resources enhances this effect. Moreover, slow redistribution of resources results in development of social networks with a very limited number of layers.
International Nuclear Information System (INIS)
Tian Shoufu; Zhang Hongqing
2010-01-01
In this paper, we start from the discrete spectral problem and construct a lattice hierarchy by properly choosing an auxiliary spectral problem V-tilde n (m) , which can reduce to the Volterra hierarchy, the Ablowitz-Ladik hierarchy, positive and negative lattice hierarchies and a new hierarchy. The new hierarchy is integrable in involutory Lax's sense and possesses multi-Hamiltonian structure. In addition, the Darboux transformation of the lattice hierarchy is obtained when the freely adjustable function εn (1) =0 and m=1. Then some soliton solutions are obtained by using Darboux transformation. This method is also suitable for other more general spectral problems in mathematics and physics.
Two hierarchies of integrable lattice equations associated with a discrete matrix spectral problem
International Nuclear Information System (INIS)
Li Xinyue; Xu Xixiang; Zhao Qiulan
2008-01-01
Two hierarchies of nonlinear integrable positive and negative lattice models are derived from a discrete spectral problem. The two lattice hierarchies are proved to have discrete zero curvature representations associated with a discrete spectral problem, which also shows that the positive and negative hierarchies correspond to positive and negative power expansions of Lax operators with respect to the spectral parameter, respectively. Moreover, the integrable lattice models in the positive hierarchy are of polynomial type, and the integrable lattice models in the negative hierarchy are of rational type. Further, we construct infinite conservation laws of the positive hierarchy, then, the integrable coupling systems of the positive hierarchy are derived from enlarging Lax pair
Implications of nonzero θ13 for the neutrino mass hierarchy
International Nuclear Information System (INIS)
Ernst, D J; Cogswell, B K; Burroughs, H R; Escamilla-Roa, J; Latimer, D C
2012-01-01
The Daya Bay, RENO, and Double Chooz experiments have discovered a large non-zero value for θ 13 . We present a global analysis that includes these three experiments, Chooz, the Super-K atmospheric data, and the ν μ → ν e T2K and MINOS experiments that are sensitive to the hierarchy and the sign of θ 13 . We report preliminary results in which we fix the mixing parameters other than θ 13 to those from a recent global analysis. Given there is no evidence for a non-zero CP violation, we assume δ = 0. T2K and MINOS lie in a region of L/E where there is a hierarchy degeneracy in the limit of θ 13 → 0 and no matter interaction. For nonzero θ 13 , the symmetry is partially broken, but a degeneracy under the simultaneous exchange of both hierarchy and the sign of θ 13 remains. Matter effects break this symmetry such that the positions of the peaks in the oscillation probabilities maintain the two-fold symmetry, while the magnitude of the oscillations is sensitive to the hierarchy. This renders T2K and NOvA, with different baselines and different matter effects, better able in combination to distinguish the hierarchy and the sign of θ 13 . The present T2K and MINOS data do not distinguish between hierarchies or the sign of θ 13 , but the large value of θ 13 yields effects from atmospheric data that do. We find for normal hierarchy, positive θ 13 , sin 2 2θ 13 = 0.090 ± 0.020 and is 0.2% probable it is the correct combination; for normal hierarchy, negative θ 13 , sin 2 2θ 13 = 0.108 ± 0.023 and is 2.2% probable; for inverse hierarchy, positive θ 13 , sin 2 2θ 13 = 0.110±0.022 and is 7.1% probable; for inverse hierarchy, negative θ 13 , sin 2 2θ 13 = 0.113 ± 0.022 and is 90.5% probable, results that are inconsistent with two similar analyses.
DEFF Research Database (Denmark)
Johnsen, Hans Erik; Meldgaard Knudsen, Lene; Mylin, Anne Kærsgaard
BACKGROUND AND OBJECTIVES Recent data have indicated that the myeloma cell hierarchy includes resistant Recent data have indicated that the myeloma cell hierarchy includes resistant circulating clonal memory B cells, which differ considerably from the classical end stage plasma cells infiltrating......, placebo controlled, single blinded, phase II study evaluating This was a randomized, placebo controlled, single blinded, phase II study evaluating toxicity and safety of Fludarabine added to Cyclophosphamide and Dexamethasone (CyDex) as induction therapy in younger patients with untreated and treatment...
Abortion: Strong's counterexamples fail
DEFF Research Database (Denmark)
Di Nucci, Ezio
2009-01-01
This paper shows that the counterexamples proposed by Strong in 2008 in the Journal of Medical Ethics to Marquis's argument against abortion fail. Strong's basic idea is that there are cases--for example, terminally ill patients--where killing an adult human being is prima facie seriously morally...
International Nuclear Information System (INIS)
Goldman, M.V.
1984-01-01
After a brief discussion of beam-excited Langmuir turbulence in the solar wind, we explain the criteria for wave-particle, three-wave and strong turbulence interactions. We then present the results of a numerical integration of the Zakharov equations, which describe the strong turbulence saturation of a weak (low-density) high energy, bump-on-tail beam instability. (author)
On the nesting of Painlevé hierarchies: A Hamiltonian approach
International Nuclear Information System (INIS)
Pickering, A.
2012-01-01
Highlights: ► Explanation of nesting of Painlevé hierarchies in terms of Hamiltonian structures. ► Approach generally phrased and applicable to continuous and discrete systems. ► Importance of related integrable hierarchies in understanding Painlevé hierarchies. - Abstract: We consider the phenomenon whereby two different Painlevé hierarchies, related to the same hierarchy of completely integrable equations, are such that solutions of one member of one of the Painlevé hierarchies are also solutions of a higher-order member of the other Painlevé hierarchy. An explanation is given in terms of the Hamiltonian structures of the related underlying completely integrable hierarchies, and is sufficiently generally formulated so as to be applicable equally to both continuous and discrete Painlevé hierarchies. Special integrals of a further Painlevé hierarchy related by Bäcklund transformation to the other Painlevé hierarchy mentioned above can also be constructed. Examples of the application of this approach to Painlevé hierarchies related to the Korteweg–de Vries, dispersive water wave, Toda and Volterra integrable hierarchies are considered. Our results provide further evidence of the importance of the underlying structures of related completely integrable hierarchies in understanding the properties of Painlevé hierarchies.
International Nuclear Information System (INIS)
Dong Huanhe; Wang Xiangrong
2008-01-01
The trace identity is extended to the quadratic-form identity. The Hamiltonian structures of the NLS-MKdV hierarchy, and integrable coupling of multi-component Levi hierarchy are obtained by the quadratic-form identity. The method can be used to produce the Hamiltonian structures of the other integrable couplings or multi-component hierarchies
Neutrino mass hierarchy determination via atmospheric neutrinos with future detectors
International Nuclear Information System (INIS)
Gandhi, Raj; Ghoshal, Pomita; Goswami, Srubabati; Mehta, Poonam; Sankar, S Uma; Shalgar, Shashank
2008-01-01
The issue of determining the neutrino mass hierarchy is one of the outstanding questions in neutrino physics. We consider the potential of hierarchy determination using atmospheric neutrinos as the source in three different proposed future detectors: A large Iron Calorimeter detector, a megaton Water Cerenkov detector and a large-mass Liquid Argon detector. If the mixing angle θ 13 is about 10 deg. (close to CHOOZ upper bound), the hierarchy sensitivity is essentially determined by resonant matter effects. To maximize the potential of these effects in atmospheric neutrinos, charge discrimination capability in the detector is desirable. Hence, detectors with this capability have an advantage in hierarchy determination. We compare and contrast the performance of the above three detectors in this respect. We perform a realistic analysis of the above future detectors for atmospheric neutrinos and show that it is possible to achieve a significant hierarchy sensitivity if the detector characteristics are favourable. Note: The abstract has been modified from its original form to incorporate suggestions received during the conference. The poster is being submitted in its original form.
SUSY-hierarchy of one-dimensional reflectionless potentials
International Nuclear Information System (INIS)
Maydanyuk, Sergei P.
2005-01-01
A class of one-dimensional reflectionless potentials is studied. It is found that all possible types of the reflectionless potentials can be combined into one SUSY-hierarchy with a constant potential. An approach for determination of a general form of the reflectionless potential on the basis of construction of such a hierarchy by the recurrent method is proposed. A general integral form of interdependence between superpotentials with neighboring numbers of this hierarchy, opening a possibility to find new reflectionless potentials, is found and has a simple analytical view. It is supposed that any possible type of the reflectionless potential can be expressed through finite number of elementary functions (unlike some presentations of the reflectionless potentials, which are constructed on the basis of soliton solutions or are shape invariant in one or many steps with involving scaling of parameters, and are expressed through series). An analysis of absolute transparency existence for the potential which has the inverse power dependence on space coordinate (and here tunneling is possible), i.e., which has the form V (x) = ± α/ vertical bar x-x 0 vertical bar n (where α and x 0 are constants, n is natural number), is fulfilled. It is shown that such a potential can be reflectionless at n = 2 only. A SUSY-hierarchy of the inverse power reflectionless potentials is constructed. Isospectral expansions of this hierarchy are analyzed
A hierarchy of time-scales and the brain.
Kiebel, Stefan J; Daunizeau, Jean; Friston, Karl J
2008-11-01
In this paper, we suggest that cortical anatomy recapitulates the temporal hierarchy that is inherent in the dynamics of environmental states. Many aspects of brain function can be understood in terms of a hierarchy of temporal scales at which representations of the environment evolve. The lowest level of this hierarchy corresponds to fast fluctuations associated with sensory processing, whereas the highest levels encode slow contextual changes in the environment, under which faster representations unfold. First, we describe a mathematical model that exploits the temporal structure of fast sensory input to track the slower trajectories of their underlying causes. This model of sensory encoding or perceptual inference establishes a proof of concept that slowly changing neuronal states can encode the paths or trajectories of faster sensory states. We then review empirical evidence that suggests that a temporal hierarchy is recapitulated in the macroscopic organization of the cortex. This anatomic-temporal hierarchy provides a comprehensive framework for understanding cortical function: the specific time-scale that engages a cortical area can be inferred by its location along a rostro-caudal gradient, which reflects the anatomical distance from primary sensory areas. This is most evident in the prefrontal cortex, where complex functions can be explained as operations on representations of the environment that change slowly. The framework provides predictions about, and principled constraints on, cortical structure-function relationships, which can be tested by manipulating the time-scales of sensory input.
A hierarchy of time-scales and the brain.
Directory of Open Access Journals (Sweden)
Stefan J Kiebel
2008-11-01
Full Text Available In this paper, we suggest that cortical anatomy recapitulates the temporal hierarchy that is inherent in the dynamics of environmental states. Many aspects of brain function can be understood in terms of a hierarchy of temporal scales at which representations of the environment evolve. The lowest level of this hierarchy corresponds to fast fluctuations associated with sensory processing, whereas the highest levels encode slow contextual changes in the environment, under which faster representations unfold. First, we describe a mathematical model that exploits the temporal structure of fast sensory input to track the slower trajectories of their underlying causes. This model of sensory encoding or perceptual inference establishes a proof of concept that slowly changing neuronal states can encode the paths or trajectories of faster sensory states. We then review empirical evidence that suggests that a temporal hierarchy is recapitulated in the macroscopic organization of the cortex. This anatomic-temporal hierarchy provides a comprehensive framework for understanding cortical function: the specific time-scale that engages a cortical area can be inferred by its location along a rostro-caudal gradient, which reflects the anatomical distance from primary sensory areas. This is most evident in the prefrontal cortex, where complex functions can be explained as operations on representations of the environment that change slowly. The framework provides predictions about, and principled constraints on, cortical structure-function relationships, which can be tested by manipulating the time-scales of sensory input.
Global network structure of dominance hierarchy of ant workers.
Shimoji, Hiroyuki; Abe, Masato S; Tsuji, Kazuki; Masuda, Naoki
2014-10-06
Dominance hierarchy among animals is widespread in various species and believed to serve to regulate resource allocation within an animal group. Unlike small groups, however, detection and quantification of linear hierarchy in large groups of animals are a difficult task. Here, we analyse aggression-based dominance hierarchies formed by worker ants in Diacamma sp. as large directed networks. We show that the observed dominance networks are perfect or approximate directed acyclic graphs, which are consistent with perfect linear hierarchy. The observed networks are also sparse and random but significantly different from networks generated through thinning of the perfect linear tournament (i.e. all individuals are linearly ranked and dominance relationship exists between every pair of individuals). These results pertain to global structure of the networks, which contrasts with the previous studies inspecting frequencies of different types of triads. In addition, the distribution of the out-degree (i.e. number of workers that the focal worker attacks), not in-degree (i.e. number of workers that attack the focal worker), of each observed network is right-skewed. Those having excessively large out-degrees are located near the top, but not the top, of the hierarchy. We also discuss evolutionary implications of the discovered properties of dominance networks. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
Visual Hierarchy and Mind Motion in Advertising Design
Directory of Open Access Journals (Sweden)
Doaa Farouk Badawy Eldesouky
2013-06-01
Full Text Available Visual hierarchy is a significant concept in the field of advertising, a field that is dominated by effective communication, visual recognition and motion. Designers of advertisements have always been trying to organize the visual hierarchy throughout their advertising designs to aid the eye to recognize information in the desired order, to achieve the ultimate goals of clear perception and effectively delivering the advertising messages. However many assumptions and questions usually rise on how to create effective hierarchy throughout advertising designs and lead the eye and mind of the viewer in the most favorable way. This paper attempts to study visual hierarchy and mind motion in advertising designs and why it is important to develop visual paths when designing an advertisement. It explores the theory behind it, and how the very principles can be used to put these concepts into practice. The paper demonstrates some advertising samples applying visual hierarchy and mind motion in a representation of applying the basics and discussing the results.
Visual Hierarchy and Mind Motion in Advertising Design
Directory of Open Access Journals (Sweden)
Doaa Farouk Badawy Eldesouky
2013-06-01
Full Text Available Visual hierarchy is a significant concept in the field of advertising, a field that is dominated by effective communication, visual recognition and motion. Designers of advertisements have always been trying to organize the visual hierarchy throughout their advertising designs to aid the eye to recognize information in the desired order, to achieve the ultimate goals of clear perception and effectively delivering the advertising messages. However many assumptions and questions usually rise on how to create effective hierarchy throughout advertising designs and lead the eye and mind of the viewer in the most favorable way. This paper attempts to study visual hierarchy and mind motion in advertising designs and why it is important to develop visual paths when designing an advertisement. It explores the theory behind it, and how the very principles can be used to put these concepts into practice. The paper demonstrates some advertising samples applying visual hierarchy and mind motion in a representation of applying the basics and discussing the results.
Quark mass hierarchies from the universal seesaw mechanism
International Nuclear Information System (INIS)
Davidson, A.; Michel, L.; Sage, M.L.; Wali, K.C.
1994-01-01
The paper is an extension of the previous work based on the idea of a universal seesaw mechanism to explain the hierarchies in the fermion mass spectrum. A model is proposed within the framework of left-right symmetry with a minimal Higgs system and an axial U(1) symmetry imposed to distinguish the generations. Previous work was confined, for mathematical simplifications, to the case of nonsingular mass matrices. In the present paper, singular matrices are considered. A systematic perturbative technique is developed to display the mass eigenvalues in terms of the vacuum expectation values of the assumed Higgs multiplets. The model successfully correlates the mass hierarchies among the quarks to the assumed hierarchies in the vacuum expectation values without appealing to a hierarchy in the Yukawa-type fermion--Higgs-boson couplings. By considering a general Higgs potential appropriate to the model, we study its minimization and prove that there exists an open subdomain in the parameter space where the orbit of the lowest minima of the potential corresponds to the kind of hierarchy in the vacuum expectation values needed for the success of the model
Dessi, Roberta; Rustichini, Aldo
2015-01-01
A large literature in psychology, and more recently in economics, has argued that monetary rewards can reduce intrinsic motivation. We investigate whether the negative impact persists when intrinsic motivation is strong, and test this hypothesis experimentally focusing on the motivation to undertake interesting and challenging tasks, informative about individual ability. We find that this type of task can generate strong intrinsic motivation, that is impervious to the effect of monetary incen...
Bitcoin Meets Strong Consistency
Decker, Christian; Seidel, Jochen; Wattenhofer, Roger
2014-01-01
The Bitcoin system only provides eventual consistency. For everyday life, the time to confirm a Bitcoin transaction is prohibitively slow. In this paper we propose a new system, built on the Bitcoin blockchain, which enables strong consistency. Our system, PeerCensus, acts as a certification authority, manages peer identities in a peer-to-peer network, and ultimately enhances Bitcoin and similar systems with strong consistency. Our extensive analysis shows that PeerCensus is in a secure state...
Strong gravity and supersymmetry
International Nuclear Information System (INIS)
Chamseddine, Ali H.; Salam, A.; Strathdee, J.
1977-11-01
A supersymmetric theory is constructed for a strong f plus a weak g graviton, together with their accompanying massive gravitinos, by gaugin the gradel 0Sp(2,2,1)x 0Sp(2,2,1) structure. The mixing term between f and g fields, which makes the strong graviton massive, can be introduced through a spontaneous symmetry-breaking mechanism implemented in this note by constructing a non-linear realization of the symmetry group
International Nuclear Information System (INIS)
Francescone, David; Akula, Sujeet; Altunkaynak, Baris; Nath, Pran
2015-01-01
Sparticle mass hierarchies contain significant information regarding the origin and nature of supersymmetry breaking. The hierarchical patterns are severely constrained by electroweak symmetry breaking as well as by the astrophysical and particle physics data. They are further constrained by the Higgs boson mass measurement. The sparticle mass hierarchies can be used to generate simplified models consistent with the high scale models. In this work we consider supergravity models with universal boundary conditions for soft parameters at the unification scale as well as supergravity models with nonuniversalities and delineate the list of sparticle mass hierarchies for the five lightest sparticles. Simplified models can be obtained by a truncation of these, retaining a smaller set of lightest particles. The mass hierarchies and their truncated versions enlarge significantly the list of simplified models currently being used in the literature. Benchmarks for a variety of supergravity unified models appropriate for SUSY searches at future colliders are also presented. The signature analysis of two benchmark models has been carried out and a discussion of the searches needed for their discovery at LHC Run-II is given. An analysis of the spin-independent neutralino-proton cross section exhibiting the Higgs boson mass dependence and the hierarchical patterns is also carried out. It is seen that a knowledge of the spin-independent neutralino-proton cross section and the neutralino mass will narrow down the list of the allowed sparticle mass hierarchies. Thus dark matter experiments along with analyses for the LHC Run-II will provide strong clues to the nature of symmetry breaking at the unification scale.
Non-Hamiltonian generalizations of the dispersionless 2DTL hierarchy
International Nuclear Information System (INIS)
Bogdanov, L V
2010-01-01
We consider two-component integrable generalizations of the dispersionless two-dimensional Toda lattice (2DTL) hierarchy connected with non-Hamiltonian vector fields, similar to the Manakov-Santini hierarchy generalizing the dKP hierarchy. They form a one-parametric family connected by hodograph-type transformations. Generating equations and Lax-Sato equations are introduced, and a dressing scheme based on the vector nonlinear Riemann problem is formulated. The simplest two-component generalization of the dispersionless 2DTL equation is derived, and its differential reduction analogous to the Dunajski interpolating system is presented. A symmetric two-component generalization of the dispersionless elliptic 2DTL equation is also constructed.
Hierarchy, Violence and Bullying Among Students of Public Middle Schools
Directory of Open Access Journals (Sweden)
José Leon Crochík
Full Text Available Abstract Hierarchies established in schools can lead to violence among students, particularly bullying, and this relationship is investigated in this study. A School Hierarchies Scale and a Peer Perception of Aggression Scale were applied to 274 9th grade students, both sexes, aged 14.08 years (SD = 0.81 old on average, attending four public schools in the state of São Paulo, Brazil. The students more frequently perceived to be popular, were among the best in physical education and/or among the worst in academic subjects were also more frequently perceived to be bullies, while those more frequently perceived to be unpopular and having the worst performance in physical education were also more frequently perceived to be victims. Therefore, teachers should reflect upon the issue and fight school violence that may arise from these hierarchies.
On an extended second Painlevé hierarchy
Gordoa, P. R.; Pickering, A.
2017-10-01
We present a new extension of the second Painlevé hierarchy and study its properties. In addition to Lax pairs, Bäcklund transformations, auto-Bäcklund transformations and basic special integrals, we also consider a new phenomenon whereby we obtain relations between systems of different orders but of the same form. The extension made here of the second Painlevé hierarchy is based on the use of non-isospectral scattering problems and so is quite general. We thus expect to be able to obtain similar extensions of other Painlevé hierarchies, including not only for continuous examples but also for discrete and differential-delay examples. We believe that our work is also of relevance for Painlevé classification, since it gives information about classes of equation that may be of interest and in addition provides a key to the possible identification of equations isolated in such a process.
SUSY-hierarchy of one-dimensional reflectionless potentials
Maydanyuk, Sergei P
2004-01-01
A class of one-dimensional reflectionless potentials, an absolute transparency of which is concerned with their belonging to one SUSY-hierarchy with a constant potential, is studied. An approach for determination of a general form of the reflectionless potential on the basis of construction of such a hierarchy by the recurrent method is proposed. A general form of interdependence between superpotentials with neighboring numbers of this hierarchy, opening a possibility to find new reflectionless potentials, have a simple analytical view and are expressed through finite number of elementary functions (unlike some reflectionless potentials, which are constructed on the basis of soliton solutions or are shape invariant in one or many steps with involving scaling of parameters, and are expressed through series), is obtained. An analysis of absolute transparency existence for the potential which has the inverse power dependence on space coordinate (and here tunneling is possible), i.e. which has the form $V(x) = \\p...
Organising evidence for environmental management decisions: a '4S' hierarchy.
Dicks, Lynn V; Walsh, Jessica C; Sutherland, William J
2014-11-01
Making decisions informed by the best-available science is an objective for many organisations managing the environment or natural resources. Yet, available science is still not widely used in environmental policy and practice. We describe a '4S' hierarchy for organising relevant science to inform decisions. This hierarchy has already revolutionised clinical practice. It is beginning to emerge for environmental management, although all four levels need substantial development before environmental decision-makers can reliably and efficiently find the evidence they need. We expose common bypass routes that currently lead to poor or biased representation of scientific knowledge. We argue that the least developed level of the hierarchy is that closest to decision-makers, placing synthesised scientific knowledge into environmental decision support systems. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
Directions for memory hierarchies and their components: research and development
International Nuclear Information System (INIS)
Smith, A.J.
1978-10-01
The memory hierarchy is usually the largest identifiable part of a computer system and making effective use of it is critical to the operation and use of the system. The levels of such a memory hierarchy are considered and the state of the art and likely directions for both research and development are described. Algorithmic and logical features of the hierarchy not directly associated with specific components are also discussed. Among the problems believed to be the most significant are the following: (a) evaluate the effectiveness of gap filler technology as a level of storage between main memory and disk, and if it proves to be effective, determine how/where it should be used, (b) develop algorithms for the use of mass storage in a large computer system, and (c) determine how cache memories should be implemented in very large, fast multiprocessor systems
Effects of neutrino oscillation on supernova neutrino: inverted mass hierarchy
International Nuclear Information System (INIS)
Takahashi, Keitaro; Sato, Katsuhiko
2003-01-01
We study the effects of neutrino oscillation on supernova neutrino in the case of the inverted mass hierarchy (m 3 1 2 ). This is an extended study of our previous study where all analyses are performed with normal mass hierarchy (m 1 2 3 ). Numerical analysis using a realistic supernova and presupernova model allow us to discuss quantitatively a possibility to probe neutrino oscillation parameters. We show that we can break partly the degeneracy of the solar neutrino problem (LMA or SMA) and probe the magnitude of θ 13 to some extent by the ratios of high-energy events and low-energy events at SuperKamiokande and SNO and the presence of the Earth effects. Further, if the magnitude of θ 13 is known roughly, we can identify the mass hierarchy
Gauge and moduli hierarchy in a multiply warped braneworld scenario
International Nuclear Information System (INIS)
Das, Ashmita; SenGupta, Soumitra
2013-01-01
Discovery of Higgs-like boson near the mass scale ∼126 Gev generates renewed interest to the gauge hierarchy problem in the standard model related to the stabilisation of the Higgs mass within Tev scale without any unnatural fine tuning. One of the successful attempts to resolve this problem has been the Randall–Sundrum warped geometry model. Subsequently this 5-dimensional model was extended to a doubly warped 6-dimensional (or higher) model which can offer a geometric explanation of the fermion mass hierarchy in the standard model of elementary particles (D. Choudhury and S. SenGupta, 2007 [1]). In an attempt to address the dark energy issue, we in this work extend such 6-dimensional warped braneworld model to include non-flat 3-branes at the orbifold fixed points such that a small but non-vanishing brane cosmological constant is induced in our observable brane. We show that the requirements of a Planck to Tev scale warping along with a vanishingly small but non-zero cosmological constant on the visible brane with non-hierarchical moduli, each with scale close to Planck length, lead to a scenario where the 3-branes can have energy scales either close to Tev or close to Planck scale. Such a scenario can address both the gauge hierarchy as well as fermion mass hierarchy problem in standard model without introducing hierarchical scales between the two moduli. Thus simultaneous resolutions to the gauge hierarchy problem, fermion mass hierarchy problem and non-hierarchical moduli problem are closely linked with the near flatness condition of our universe.
Dynamical Flavor Hierarchy and Heavy Top
Dvali, Gia; Dvali, Gia; Kakushadze, Zurab
1998-01-01
In the Standard Model one of the generations is much heavier than the other two. We propose a simple mechanism where all three generations are treated on the equal footing to begin with, and one heavy and two light families emerge from supersymmetric strong dynamics. The Yukawa mass matrix is identified with vevs of the meson fields of some additional gauge theory. It is then forced to have rank one (in the leading order) by non-perturbative superpotential.
International Nuclear Information System (INIS)
Li Xinyue; Zhao Qiulan
2009-01-01
Two hierarchies of nonlinear integrable positive and negative lattice equations are derived from a discrete spectral problem. The two lattice hierarchies are proved to have discrete zero curvature representations associated with a discrete spectral problem, which also shows that the positive and negative hierarchies correspond to positive and negative power expansions of Lax operators with respect to the spectral parameter, respectively. Moreover, the integrable lattice models in the positive hierarchy are of polynomial type, and the integrable lattice models in the negative hierarchy are of rational type. Further, we construct infinite conservation laws about the positive hierarchy.
An Operational Foundation for Delimited Continuations in the CPS Hierarchy
DEFF Research Database (Denmark)
Biernacka, Malgorzata; Biernacki, Dariusz; Danvy, Olivier
2004-01-01
We present an abstract machine and a reduction semantics for the lambda-calculus extended with control operators that give access to delimited continuations in the CPS hierarchy. The abstract machine is derived from an evaluator in continuation-passing style (CPS); the reduction semantics (i.......e., a small-step operational semantics with an explicit representation of evaluation contexts) is constructed from the abstract machine; and the control operators are the shift and reset family. We also present new applications of delimited continuations in the CPS hierarchy: finding list prefixes...
An Operational Foundation for Delimited Continuations in the CPS Hierarchy
DEFF Research Database (Denmark)
Biernacka, Malgorzata; Biernacki, Dariusz; Danvy, Olivier
2005-01-01
We present an abstract machine and a reduction semantics for the lambda-calculus extended with control operators that give access to delimited continuations in the CPS hierarchy. The abstract machine is derived from an evaluator in continuation-passing style (CPS); the reduction semantics (i.......e., a small-step operational semantics with an explicit representation of evaluation contexts) is constructed from the abstract machine; and the control operators are the shift and reset family. We also present new applications of delimited continuations in the CPS hierarchy: finding list prefixes...
Fermion mass hierarchies and flavor mixing from T' symmetry
International Nuclear Information System (INIS)
Ding Guijun
2008-01-01
We construct a supersymmetric model based on T ' x Z 3 x Z 9 flavor symmetry. At the leading order, the charged lepton mass matrix is not diagonal, T ' is broken completely, and the hierarchy in the charged lepton masses is generated naturally. Nearly tribimaximal mixing is predicted, and subleading effects induce corrections of order λ 2 , where λ is the Cabibbo angle. Both the up quark and down quark mass matrices' textures of the well-known U(2) flavor theory are produced at the leading order; realistic hierarchies in quark masses and Cabibbo-Kobayashi-Maskawa matrix elements are obtained. The vacuum alignment and subleading corrections are discussed in detail.
KdV hierarchy via Abelian coverings and operator identities
Eichinger, Benjamin; VandenBoom, Tom; Yuditskii, Peter
2018-01-01
We establish precise spectral criteria for potential functions $V$ of reflectionless Schr\\"odinger operators $L_V = -\\partial_x^2 + V$ to admit solutions to the Korteweg de-Vries (KdV) hierarchy with $V$ as an initial value. More generally, our methods extend the classical study of algebro-geometric solutions for the KdV hierarchy to noncompact Riemann surfaces by defining generalized Abelian integrals and analogues of the Baker-Akhiezer function on infinitely connected domains with a uniform...
Detecting Hidden Hierarchy of Non Hierarchical Terrorist Networks
DEFF Research Database (Denmark)
Memon, Nasrullah
measures (and combinations of them) to identify key players (important nodes) in terrorist networks. Our recently introduced techniques and algorithms (which are also implemented in the investigative data mining toolkit known as iMiner) will be particularly useful for law enforcement agencies that need...... to analyze terrorist networks and prioritize their targets. Applying recently introduced mathematical methods for constructing the hidden hierarchy of "nonhierarchical" terrorist networks; we present case studies of the terrorist attacks occurred / planned in the past, in order to identify hidden hierarchy...
The influence of social hierarchy on primate health.
Sapolsky, Robert M
2005-04-29
Dominance hierarchies occur in numerous social species, and rank within them can greatly influence the quality of life of an animal. In this review, I consider how rank can also influence physiology and health. I first consider whether it is high- or low-ranking animals that are most stressed in a dominance hierarchy; this turns out to vary as a function of the social organization in different species and populations. I then review how the stressful characteristics of social rank have adverse adrenocortical, cardiovascular, reproductive, immunological, and neurobiological consequences. Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status.
Closed hierarchy of correlations in Markovian open quantum systems
International Nuclear Information System (INIS)
Žunkovič, Bojan
2014-01-01
We study the Lindblad master equation in the space of operators and provide simple criteria for closeness of the hierarchy of equations for correlations. We separately consider the time evolution of closed and open systems and show that open systems satisfying the closeness conditions are not necessarily of Gaussian type. In addition, we show that dissipation can induce the closeness of the hierarchy of correlations in interacting quantum systems. As an example we study an interacting optomechanical model, the Fermi–Hubbard model, and the Rabi model, all coupled to a fine-tuned Markovian environment and obtain exact analytic expressions for the time evolution of two-point correlations. (paper)
Common Origin for Neutrino Anarchy and Charged Hierarchies
International Nuclear Information System (INIS)
Agashe, Kaustubh; Okui, Takemichi; Sundrum, Raman
2009-01-01
The generation of exponential flavor hierarchies from extra-dimensional wave function overlaps is reexamined. We find, surprisingly, that the coexistence of anarchic fermion mass matrices with such hierarchies is intrinsic and natural to this setting. The salient features of charged fermion and neutrino masses and mixings can thereby be captured within a single framework. Both Dirac and Majorana neutrinos can be realized. Implications for a variety of weak-scale scenarios, including warped compactification and supersymmetry, are discussed. When the new weak-scale physics is sensitive to the origin of flavor structure, Dirac neutrinos are preferred
On hierarchy in asymptotic reconstruction of spontaneously broken isotopic symmetry
International Nuclear Information System (INIS)
Ermolaev, B.I.
1978-01-01
The isotopic features of the effective current-current lagrangian of the Lsub(eff) electromagnetic-weak interaction between elementary particles are treated at large momentum transfers using the Weinberg-Salam model. Transition to other models may be made by analogy. It is shown that when the collision energies of elementary particles exceed 90 GeV one may expect the hierarchy in the asymptotic reconstruction of the isotopic symmetry. Such hierarchy could be observed, in particular, in experiments on elastic leptonic collisions at high energies
Dynamical generation of hierarchy in GUTs with softly broken supersymmetry
International Nuclear Information System (INIS)
Tabata, K.; Umemura, I.; Yamamoto, K.
1983-01-01
Characteristic aspects of Dimopoulos-Georgi's mechanism for the hierarchy are investigated in a 'semi-realistic' SU(5) model by employing the renormalization group method. The hierarchy is really generated in a 'sick' theory by quantum resuscitation without any fine tuning of the coupling constants at Msub(W) approx.= 10 2 GeV. It can also be realized in a 'normal' theory by choosing the coupling constants suitably. In the latter case, the effective potential has two minima at X = 0 and Msub(G). Some suggestions are presented for constructing a realistic model. (orig.)
Hierarchy plus anarchy in quark masses and mixings
International Nuclear Information System (INIS)
Aguilar-Saavedra, J.A.
2003-01-01
We introduce a parametrization of the effect of unknown corrections from new physics on quark and lepton mass matrices. This parametrization is used in order to study how the hierarchies of quark masses and mixing angles are modified by random perturbations of the Yukawa matrices. We discuss several examples of flavor relations predicted by different textures, analyzing how these relations are influenced by the random perturbations. We also comment on the unlikely possibility that unknown corrections contribute significantly to the hierarchy of masses and mixings
DEFF Research Database (Denmark)
Brix, Thomas Heiberg; Hegedüs, Laszlo; Gardas, Andrzej
2010-01-01
Thyroid peroxidase antibodies (TPOAbs) in patients with Hashimoto's thyroiditis (HT) predominantly react with two immunodominant regions (IDR-A, IDR-B). Theoretically, as shown for the level of TPOAbs, the autoantibody epitopic recognition of the IDRs could be under genetic control. To examine this......, we compared the distribution of TPOAb epitopic fingerprints between healthy monozygotic (MZ) co-twins and siblings to patients with clinically overt HT with a control group of euthyroid subjects, matched for sex and age, but without autoimmune thyroid disease (AITD) among their first-degree relatives...
Migration up and down the urban hierarchy and across the life course.
Plane, D A; Henrie, C J; Perry, M J
2005-10-25
In this article, we begin by reviewing the concept of step migration that originated in E. G. Ravenstein's seminal papers "The Laws of Migration" (1885, 1889). As a result of the forces of the Industrial Revolution underway in 19th century Great Britain, migrants moved from farms to villages, from villages to towns, from towns to county seats, and thence to large cities. Throughout much of the industrialization era in the United States, net population movements similarly were upward within the urban hierarchy, and step migration today remains widespread throughout much of the still developing world. Our investigations of recent data and trends, however, suggest that the latest U.S. migration-pattern regime is a strongly contrasting one. Many of the major movements in the system of internal (or domestic) migration are flows down the urban hierarchy, although we note highly differentiated patterns for persons and households at specific stages of the life course. We make use of the newly defined metropolitan and micropolitan Core-Based Statistical Areas (CBSAs) and a seven-level size typology to tabulate origin-destination-specific migration flow data from both Census 2000 and IRS tax-return administrative records for the period 1995-2000. We discuss the causes for net movements being either upward or downward in the national urban hierarchy, including the effects of spatially focused immigration, and movement preferences at various ages, including migration in young adulthood associated with entering and leaving college and the military, as well as moves characteristic of the stages of family formation, childrearing, and retirement.
Strongly interacting Fermi gases
Directory of Open Access Journals (Sweden)
Bakr W.
2013-08-01
Full Text Available Strongly interacting gases of ultracold fermions have become an amazingly rich test-bed for many-body theories of fermionic matter. Here we present our recent experiments on these systems. Firstly, we discuss high-precision measurements on the thermodynamics of a strongly interacting Fermi gas across the superfluid transition. The onset of superfluidity is directly observed in the compressibility, the chemical potential, the entropy, and the heat capacity. Our measurements provide benchmarks for current many-body theories on strongly interacting fermions. Secondly, we have studied the evolution of fermion pairing from three to two dimensions in these gases, relating to the physics of layered superconductors. In the presence of p-wave interactions, Fermi gases are predicted to display toplogical superfluidity carrying Majorana edge states. Two possible avenues in this direction are discussed, our creation and direct observation of spin-orbit coupling in Fermi gases and the creation of fermionic molecules of 23Na 40K that will feature strong dipolar interactions in their absolute ground state.
International Nuclear Information System (INIS)
Marier, D.
1992-01-01
This article presents the results of a financial rankings survey which show a strong economic activity in the independent energy industry. The topics of the article include advisor turnover, overseas banks, and the increase in public offerings. The article identifies the top project finance investors for new projects and restructurings and rankings for lenders
Goal hierarchy: Improving asset data quality by improving motivation
Energy Technology Data Exchange (ETDEWEB)
Unsworth, Kerrie, E-mail: Kerrie.unsworth@uwa.edu.au [UWA Business School, University of Western Australia, Crawley, WA 6009 (Australia); Adriasola, Elisa; Johnston-Billings, Amber; Dmitrieva, Alina [UWA Business School, University of Western Australia, Crawley, WA 6009 (Australia); Hodkiewicz, Melinda [School of Mechanical Engineering, University of Western Australia, Crawley, WA 6009 (Australia)
2011-11-15
Many have recognized the need for high quality data on assets and the problems in obtaining them, particularly when there is a need for human observation and manual recording. Yet very few have looked at the role of the data collectors themselves in the data quality process. This paper argues that there are benefits to more fully understanding the psychological factors that lay behind data collection and we use goal hierarchy theory to understand these factors. Given the myriad of potential reasons for poor-quality data it has previously proven difficult to identify and successfully deploy employee-driven interventions; however, the goal hierarchy approach looks at all of the goals that an individual has in their life and the connections between them. For instance, does collecting data relate to whether or not they get a promotion? Stay safe? Get a new job? and so on. By eliciting these goals and their connections we can identify commonalities across different groups, sites or organizations that can influence the quality of data collection. Thus, rather than assuming what the data collectors want, a goal hierarchy approach determines that empirically. Practically, this supports the development of customized interventions that will be much more effective and sustainable than previous efforts. - Highlights: > We need to consider psychological aspects of data collectors to improve data quality. > We show how goal hierarchy theory furthers understanding. > Looks at the multiple goals of each individual to determine their behavior.
Tissue-specific designs of stem cell hierarchies
Visvader, Jane E.; Clevers, Hans
2016-01-01
Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in
The Hierarchy of Minority Languages in New Zealand
de Bres, Julia
2015-01-01
This article makes a case for the existence of a minority language hierarchy in New Zealand. Based on an analysis of language ideologies expressed in recent policy documents and interviews with policymakers and representatives of minority language communities, it presents the arguments forwarded in support of the promotion of different types of…
Natural fermion mass hierarchy and mixings in family unification
International Nuclear Information System (INIS)
Dent, James B.; Feger, Robert; Kephart, Thomas W.; Nandi, S.
2011-01-01
We present an SU(9) model of family unification with three light chiral families, and a natural hierarchy of charged fermion masses and mixings. The existence of singlet right handed neutrinos with masses about two orders of magnitude smaller than the GUT scale, as needed to understand the light neutrinos masses via the see-saw mechanism, is compelling in our model.
Impact of hierarchy upon the values of neutrino mixing parameters
International Nuclear Information System (INIS)
Escamilla-Roa, J.; Ernst, D. J.; Latimer, D. C.
2010-01-01
A neutrino-oscillation analysis is performed of the more finely binned Super-Kamiokande (Super-K) atmospheric, MINOS, and CHOOZ data to examine the effect of neutrino hierarchy in this data set on the value of θ 13 and the deviation of θ 23 from maximal mixing. Exact oscillation probabilities are used, thus incorporating all powers of θ 13 and ε:=θ 23 -π/4. The extracted oscillation parameters are found to be dependent on the hierarchy, particularly for θ 13 . We find, at a 90% confidence level, that these parameters are Δ 32 =2.44 -0.20 +0.26 and 2.48 -0.22 +0.25 x10 -3 eV 2 , ε=θ 23 -π/4=0.06 -0.16 +0.06 and 0.06 -0.17 +0.08 , and θ 13 =-0.07 -0.11 +0.18 and -0.13 -0.16 +0.23 , for the normal and inverted hierarchies, respectively. The inverted hierarchy is preferred at a statistically insignificant level of 0.3σ.
Effects of Hierarchy Vocabulary Exercises on English Vocabulary Acquisition
Lin, Ching-Ying; Hsu, Wei Shu
2013-01-01
The purpose of the study was to compare the effectiveness of hierarchy vocabulary exercises and copying vocabulary exercises on EFL students' vocabulary acquisition and reading comprehension. Two specific factors were probed: (a) vocabulary gains and retention from different exercises; (b) reading comprehension performance through different…
Supersymmetry : the ultimate hierarchy of matter? Exhibition LEPFest 2000
2000-01-01
The concept of "Supersymmetry", SUSY for short, promises a solution to the 'hierarchy' problem: the mystery of the enormous ratio between the electroweak scale (at 100-300 GeV), defined by the masses of the W and Z particles, and possibly the Higgs particle, and the Planck scale (10 19 GeV), when gravitational effects become comparable to the other forces.
The role of hierarchy in self-organizing systems
Ollfen, van W.; Romme, A.G.L.
1995-01-01
This paper discusses the role of hierarchy in human systems. Two kinds of self-organizing processes are distinguished: conservative and dissipative self-organization. The former leads to rather stable, specialistic systems, whereas the latter leads to continuously changing generalistic systems. When
The problem of using hierarchy for implementing organisational innovation
Schuring, R.W.; Harbers, Clementine; Harbers, C.C.E.; Kruiswijk, M.; Kruiswijk, Martine; Rijnders, Sander; Boer, Harm
2003-01-01
Neither science nor practice seems to regard the implementation of a continuous improvement (CI) programme as a problematic organisational innovation. Many organisations do not regard CI implementation as a major change and tend to use their existing hierarchy to organise and manage the process.
Object class hierarchy for an incremental hypertext editor
Directory of Open Access Journals (Sweden)
A. Colesnicov
1995-02-01
Full Text Available The object class hierarchy design is considered due to a hypertext editor implementation. The following basic classes were selected: the editor's coordinate system, the memory manager, the text buffer executing basic editing operations, the inherited hypertext buffer, the edit window, the multi-window shell. Special hypertext editing features, the incremental hypertext creation support and further generalizations are discussed.
Handelman's hierarchy for the maximum stable set problem
Laurent, M.; Sun, Z.
2014-01-01
The maximum stable set problem is a well-known NP-hard problem in combinatorial optimization, which can be formulated as the maximization of a quadratic square-free polynomial over the (Boolean) hypercube. We investigate a hierarchy of linear programming relaxations for this problem, based on a
Symmetries of integrable hierarchies and matrix model constraints
International Nuclear Information System (INIS)
Vos, K. de
1992-01-01
The orbit construction associates a soliton hierarchy to every level-one vertex realization of a simply laced affine Kac-Moody algebra g. We show that the τ-function of such a hierarchy has the (truncated) Virasoro algebra as an algebra of infinitesimal symmetry transformations. To prove this we use an appropriate bilinear form of these hierarchies together with the coset construction of conformal field theory. For A 1 (1) the orbit construction gives either the Toda or the KdV hierarchy. These both occur in the one-matrix model of two-dimensional quantum gravity, before and after the double scaling limit respectively. The truncated Virasoro symmetry algebra is exactly the algebra of constraints of the one-matrix model. The partition function of the one-matrix model is therefore an invariant τ-function. We also consider the case of A 1 (1) with l>1. Surprisingly, the symmetry algebra in that case is not simply a truncated Casimir algebra. It appears that again only the Virasoro symmetry survives. We speculate on the relation with multi-matrix models. (orig.)
Shoot and root biomass allocation and competitive hierarchies of ...
African Journals Online (AJOL)
Shoot and root biomass allocation and competitive hierarchies of four South African grass species on light, soil resources and cutting gradients. ... Aristida junciformis, produced nearly double the biomass of taller species such as Hyparrhenia hirta and Eragrostis curvula in the low-nutrient treatments, with the reverse being ...
Optimal design of nuclear mechanical dampers with analytical hierarchy process
International Nuclear Information System (INIS)
Zou Yuehua; Wen Bo; Xu Hongxiang; Qin Yonglie
2000-01-01
An optimal design with analytical hierarchy process on nuclear mechanical dampers manufactured by authors' university was described. By using fuzzy judgement matrix the coincidence was automatically satisfied without the need of coincidence test. The results obtained by this method have been put into the production practices
A note on the extended dispersionless Toda hierarchy
Lee, Niann-Chern; Tu, Ming-Hsien
2013-04-01
We derive dispersionless Hirota equations for the extended dispersionless Toda hierarchy. We show that the dispersionless Hirota equations are just a direct consequence of the genus-zero topological recurrence relation for the topological ℂP1 model. Using the dispersionless Hirota equations, we compute the twopoint functions and express the result in terms of Catalan numbers
Tissue-specific designs of stem cell hierarchies
Visvader, Jane E; Clevers, Hans
Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in
The Euromanager profile: a hierarchy of competences? : a workshop report
Merk, V.J.B.A.; March, D.; Salo-Lee, L.
1994-01-01
In this interdisciplinary workshop we will examine the competences required of the internationally oriented business-person, e.g. professional, conceptual, interpersonal and cultural (in its many varieties) and attempt to place them in a hierarchy of significance. In the discussion we intend to
Bibliometric Evidence for a Hierarchy of the Sciences.
Fanelli, Daniele; Glänzel, Wolfgang
2013-01-01
The hypothesis of a Hierarchy of the Sciences, first formulated in the 19(th) century, predicts that, moving from simple and general phenomena (e.g. particle dynamics) to complex and particular (e.g. human behaviour), researchers lose ability to reach theoretical and methodological consensus. This hypothesis places each field of research along a continuum of complexity and "softness", with profound implications for our understanding of scientific knowledge. Today, however, the idea is still unproven and philosophically overlooked, too often confused with simplistic dichotomies that contrast natural and social sciences, or science and the humanities. Empirical tests of the hypothesis have usually compared few fields and this, combined with other limitations, makes their results contradictory and inconclusive. We verified whether discipline characteristics reflect a hierarchy, a dichotomy or neither, by sampling nearly 29,000 papers published contemporaneously in 12 disciplines and measuring a set of parameters hypothesised to reflect theoretical and methodological consensus. The biological sciences had in most cases intermediate values between the physical and the social, with bio-molecular disciplines appearing harder than zoology, botany or ecology. In multivariable analyses, most of these parameters were independent predictors of the hierarchy, even when mathematics and the humanities were included. These results support a "gradualist" view of scientific knowledge, suggesting that the Hierarchy of the Sciences provides the best rational framework to understand disciplines' diversity. A deeper grasp of the relationship between subject matter's complexity and consensus could have profound implications for how we interpret, publish, popularize and administer scientific research.
Extending the applicability of the analytic hierarchy process
Huizingh, K.R.E.; Vrolijk, H.C.J.
The Analytic Hierarchy Process (AHP) has often been used to support decisions that only have to be made once. in this study, we explore whether the AHP can be applied to repetitive decision-making. We suggest a variant of the process to elicit implicit decision models that evaluate alternatives not
Using the Analytic Hierarchy Process to Analyze Multiattribute Decisions.
Spires, Eric E.
1991-01-01
The use of the Analytic Hierarchy Process (AHP) in assisting researchers to analyze decisions is discussed. The AHP is compared with other decision-analysis techniques, including multiattribute utility measurement, conjoint analysis, and general linear models. Insights that AHP can provide are illustrated with data gathered in an auditing context.…
Optimizing an Immersion ESL Curriculum Using Analytic Hierarchy Process
Tang, Hui-Wen Vivian
2011-01-01
The main purpose of this study is to fill a substantial knowledge gap regarding reaching a uniform group decision in English curriculum design and planning. A comprehensive content-based course criterion model extracted from existing literature and expert opinions was developed. Analytical hierarchy process (AHP) was used to identify the relative…
Assessing Adult Learning Preferences Using the Analytic Hierarchy Process.
Lee, Doris; McCool, John; Napieralski, Laura
2000-01-01
Graduate students (n=134) used the analytic hierarchy process, which weights expressed preferences, to rate four learning activities: lectures, discussion/reflection, individual projects, and group projects. Their preferences for discussion/reflection and individual projects were independent of auditory, visual, and kinesthetic learning styles.…
Maslow's Need Hierarchy and the Adjustment of Immigrants
Adler, Seymour
1977-01-01
In this paper the need hierarchy theory of Abraham Maslow is used to describe stages in the adjustment process of new immigrants. This notion is developed and applied to interpreting some longitudinal data on the changing needs of immigrants to Israel during the first two years after their arrival. (Author/GC)
Student Affairs as Perceived Through Abraham Maslow's Hierarchy of Needs.
Nowacki, Steven
The needs of human behavior are explored and correlated to the various departments within Student Affairs in an effort to show how Student Affairs can satisfy those needs. Maslow's Hierarchy of needs is briefly explained and related to the following Student Affairs departments: Financial Aid, Student Management, Career Development and Placement,…
Fuzzy analytical hierarchy process and GIS for predictive cu -au ...
African Journals Online (AJOL)
Mineral exploration generally starts on small scale (small areas) and, then progresses to large scale (small area). There are many methods for achieving this goal. To achieve this goal one of these methods is Fuzzy analytical hierarchy process (Fuzzy AHP) that is the most popular multi-criteria decision-making techniques.
Flavour democracy and the lepton-quark hierarchy
International Nuclear Information System (INIS)
Fritzsch, H.; Muenchen Univ.; Plankl, J.
1990-01-01
The mass hierarchy of the leptons and quarks is interpreted as a consequence of a coherent state phenomenon ('flavour democracy'). It is emphasized that particular forms of the mass matrices can arise from the coherent state basis. The violations of the 'flavour democracy' turn out to be relatively large. Numerical examples are presented. (orig.)
Social hierarchy and depression: the role of emotion suppression.
Langner, Carrie A; Epel, Elissa S; Matthews, Karen A; Moskowitz, Judith T; Adler, Nancy E
2012-01-01
Position in the social hierarchy is a major determinant of health outcomes. We examined the associations between aspects of social hierarchy and depressive symptoms with a specific focus on one potential psychological mechanism: emotion suppression. Suppressing negative emotion has mental health costs, but individuals with low social power and low social status may use these strategies to avoid conflict. Study 1 assessed perceived social power, tendency to suppress negative emotion, and depressive symptoms in a community sample of women. Low social power was related to greater depressive symptoms, and this relationship was partially mediated by emotion suppression. Study 2 examined education as a proxy for social hierarchy position, anger suppression, and depressive symptoms in a national, longitudinal cohort study (The coronary artery risk development in young adults [CARDIA] study; Cutter et al., 1991). Much as in study 1, low education levels were correlated with greater depressive symptoms, and this relationship was partially mediated by anger suppression. Further, suppression mediated the relationship between low education and subsequent depression up to 15 years later. These findings support the theory that social hierarchy affects mental health in part through a process of emotion suppression.
A formula relating infinitesimal Backlund transformations to hierarchy generating operators
International Nuclear Information System (INIS)
Hou, B.Y.; Tu, G.Z.
1982-12-01
Let u'=Bsub(eta)u and l be, respectively, the elementary Backlund transformation and hierarchy generating operators for the AKNS equations. It is shown that (dB/d eta)(Bsub(eta)) - 1 =σ 3 /(l-eta). A similar formula relating to the general NxN matrix spectral problem is also derived. (author)
Goal hierarchy: Improving asset data quality by improving motivation
International Nuclear Information System (INIS)
Unsworth, Kerrie; Adriasola, Elisa; Johnston-Billings, Amber; Dmitrieva, Alina; Hodkiewicz, Melinda
2011-01-01
Many have recognized the need for high quality data on assets and the problems in obtaining them, particularly when there is a need for human observation and manual recording. Yet very few have looked at the role of the data collectors themselves in the data quality process. This paper argues that there are benefits to more fully understanding the psychological factors that lay behind data collection and we use goal hierarchy theory to understand these factors. Given the myriad of potential reasons for poor-quality data it has previously proven difficult to identify and successfully deploy employee-driven interventions; however, the goal hierarchy approach looks at all of the goals that an individual has in their life and the connections between them. For instance, does collecting data relate to whether or not they get a promotion? Stay safe? Get a new job? and so on. By eliciting these goals and their connections we can identify commonalities across different groups, sites or organizations that can influence the quality of data collection. Thus, rather than assuming what the data collectors want, a goal hierarchy approach determines that empirically. Practically, this supports the development of customized interventions that will be much more effective and sustainable than previous efforts. - Highlights: → We need to consider psychological aspects of data collectors to improve data quality. → We show how goal hierarchy theory furthers understanding. → Looks at the multiple goals of each individual to determine their behavior.
A Program Based on Maslow's Hierarchy Helps Students in Trouble
Yates, Mary Ruth; Saunders, Ron; Watkins, J. Foster
1980-01-01
The article discusses the development of an "alternative school" in an urban school system for students having trouble in the regular secondary setting. The program was based upon "Maslow's Hierarchy of Needs" and is described in detail. The initial assessment of the program produced very positive results.
Plasticity within stem cell hierarchies in mammalian epithelia
Tetteh, Paul W; Farin, Henner F; Clevers, Hans
Tissue homeostasis and regeneration are fueled by resident stem cells that have the capacity to self-renew, and to generate all the differentiated cell types that characterize a particular tissue. Classical models of such cellular hierarchies propose that commitment and differentiation occur
Knowledge-Based Hierarchies: Using Organizations to Understand the Economy
Garicano, Luis; Rossi-Hansberg, Esteban
2015-01-01
Incorporating the decision of how to organize the acquisition, use, and communication of knowledge into economic models is essential to understand a wide variety of economic phenomena. We survey the literature that has used knowledge-based hierarchies to study issues such as the evolution of wage inequality, the growth and productivity of firms,…
The Alternation Hierarchy for the Theory of µ-lattices
DEFF Research Database (Denmark)
Santocanale, Luigi
2002-01-01
independent of φ. In this paper we give a proof that the alternation hierarchy for the theory of µ-lattices is strict, meaning that such a constant does not exist if µ-term are built up from the basic lattice operations and are interpreted as expected. The proof relies on the explicit characterization of free...
The non-isospectral AKNS hierarchy with reality conditions restriction
International Nuclear Information System (INIS)
Zhou Lingjun
2008-01-01
In this paper, we will prove the existence of the non-isospectral AKNS hierarchy with reality conditions restriction and construct the matrix form Darboux transformation. Using this Darboux transformation, the solutions of the relevant nonlinear equations can be expressed explicitly
Integrable coupling system of fractional soliton equation hierarchy
Energy Technology Data Exchange (ETDEWEB)
Yu Fajun, E-mail: yfajun@163.co [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China)
2009-10-05
In this Letter, we consider the derivatives and integrals of fractional order and present a class of the integrable coupling system of the fractional order soliton equations. The fractional order coupled Boussinesq and KdV equations are the special cases of this class. Furthermore, the fractional AKNS soliton equation hierarchy is obtained.
Can nonstandard interactions jeopardize the hierarchy sensitivity of DUNE?
Deepthi, K. N.; Goswami, Srubabati; Nath, Newton
2017-10-01
We study the effect of nonstandard interactions (NSIs) on the propagation of neutrinos through the Earth's matter and how it affects the hierarchy sensitivity of the DUNE experiment. We emphasize the special case when the diagonal NSI parameter ɛe e=-1 , nullifying the standard matter effect. We show that if, in addition, C P violation is maximal then this gives rise to an exact intrinsic hierarchy degeneracy in the appearance channel, irrespective of the baseline and energy. Introduction of the off diagonal NSI parameter, ɛe τ, shifts the position of this degeneracy to a different ɛe e. Moreover the unknown magnitude and phases of the off diagonal NSI parameters can give rise to additional degeneracies. Overall, given the current model independent limits on NSI parameters, the hierarchy sensitivity of DUNE can get seriously impacted. However, a more precise knowledge of the NSI parameters, especially ɛe e, can give rise to an improved sensitivity. Alternatively, if a NSI exists in nature, and still DUNE shows hierarchy sensitivity, certain ranges of the NSI parameters can be excluded. Additionally, we briefly discuss the implications of ɛe e=-1 (in the Earth) on the Mikheyev-Smirnov-Wolfenstein effect in the Sun.
Pupil dilation indexes the metrical hierarchy of unattended rhythmic violations
Damsma, Atser; van Rijn, Dirk
2017-01-01
When we listen to music, we perceive regularities that drive our expectations. This is reflected in beat perception, in which a listener infers a regular pulse from a rhythm. However, it is still an open question whether attention to the music is necessary to establish the perception of a hierarchy
Organizational Hierarchy, Employee Status, and Use of Employee Assistance Programs.
Gerstein, Lawrence; And Others
1993-01-01
Examined role of organizational hierarchy and staff status in number of Employee Assistance Program (EAP) referrals made by potential helpers and relationship of these variables to personal EAP use among 157 supervisors and 232 employees. Supervisors suggested more EAP referrals than did employees. Middle level staff received EAP services more…
Evaluating Modeling Sessions Using the Analytic Hierarchy Process
Ssebuggwawo, D.; Hoppenbrouwers, S.J.B.A.; Proper, H.A.; Persson, A.; Stirna, J.
2008-01-01
In this paper, which is methodological in nature, we propose to use an established method from the field of Operations Research, the Analytic Hierarchy Process (AHP), in the integrated, stakeholder- oriented evaluation of enterprise modeling sessions: their language, pro- cess, tool (medium), and
Language variety, language hierarchy, and language choice in the international university
DEFF Research Database (Denmark)
Haberland, Hartmut; Mortensen, Janus
2012-01-01
Introduction to thematic issue on Language variety, language hierarchy, and language choice in the international university......Introduction to thematic issue on Language variety, language hierarchy, and language choice in the international university...
Agile and Resilient Hierarchies for Defense Departments: Lofty Ideal or an Actionable Proposal
National Research Council Canada - National Science Library
Desouza, Kevin C
2006-01-01
... only consideration. Completely agile structures may lose the benefits bestowed by hierarchies. Rather the Defense Department should work towards agile and resilient hierarchies that can recover quickly following setbacks.
Hamiltonian structure of the integrable coupling of the Jaulent-Miodek hierarchy
International Nuclear Information System (INIS)
Zhang, Yufeng; Fan, Engui
2006-01-01
A scheme for deducing Hamiltonian structures of the higher-dimensional hierarchies of evolution equations is presented which is devoting to obtaining the Hamiltonian structures of integrable coupling of the Jaulent-Miodek hierarchy
Directory of Open Access Journals (Sweden)
Aniuska Becerra-Artiles
Full Text Available Most of humanity is chronically infected with human herpesvirus 6 (HHV-6, with viral replication controlled at least in part by a poorly characterized CD4 T cell response. Identification of viral epitopes recognized by CD4 T cells is complicated by the large size of the herpesvirus genome and a low frequency of circulating T cells responding to the virus. Here, we present an alternative to classical epitope mapping approaches used to identify major targets of the T cell response to a complex pathogen like HHV-6B. In the approach presented here, extracellular virus preparations or virus-infected cells are fractionated by SDS-PAGE, and eluted fractions are used as source of antigens to study cytokine responses in direct ex vivo T cell activation studies. Fractions inducing significant cytokine responses are analyzed by mass spectrometry to identify viral proteins, and a subset of peptides from these proteins corresponding to predicted HLA-DR binders is tested for IFN-γ production in seropositive donors with diverse HLA haplotypes. Ten HHV-6B viral proteins were identified as immunodominant antigens. The epitope-specific response to HHV-6B virus was complex and variable between individuals. We identified 107 peptides, each recognized by at least one donor, with each donor having a distinctive footprint. Fourteen peptides showed responses in the majority of donors. Responses to these epitopes were validated using in vitro expanded cells and naturally expressed viral proteins. Predicted peptide binding affinities for the eight HLA-DRB1 alleles investigated here correlated only modestly with the observed CD4 T cell responses. Overall, the response to the virus was dominated by peptides from the major capsid protein U57 and major antigenic protein U11, but responses to other proteins including glycoprotein H (U48 and tegument proteins U54 and U14 also were observed. These results provide a means to follow and potentially modulate the CD4 T-cell immune
Tapeinou, Anthi; Giannopoulou, Efstathia; Simal, Carmen; Hansen, Bjarke E; Kalofonos, Haralabos; Apostolopoulos, Vasso; Vlamis-Gardikas, Alexios; Tselios, Theodore
2018-01-01
Anthraquinone type compounds, especially di-substituted amino alkylamino anthraquinones have been widely studied as immunosuppressants. The anthraquinone ring is part of mitoxandrone that has been used for the treatment of multiple sclerosis (MS) and several types of tumors. A desired approach for the treatment of MS would be the immunosuppression and elimination of specific T cells that are responsible for the induction of the disease. Herein, the development of a peptide compound bearing an anthraquinone derivative with the potential to specifically destroy the encephalitogenic T cells responsible for the onset of MS is described. The compound consists of the myelin basic protein (MBP) 85-99 immunodominant epitope (MBP 85-99 ) coupled to an anthraquinone type molecule (AQ) via a disulfide (S-S) and 6 amino hexanoic acid (Ahx) residues (AQ-S-S-(Ahx) 6 MBP 85-99 ). AQ-S-S-(Ahx) 6 MBP 85-99 could bind to HLA II DRB1*-1501 antigen with reasonable affinity (IC 50 of 56 nM) The compound was localized to the nucleus of Jurkat cells (an immortalized line of human T lymphocytes) 10 min after its addition to the medium and resulted in lowered Bcl-2 levels (apoptosis). Entrance of the compound was abolished when cells were pre-treated with cisplatin, an inhibitor of thioredoxin reductase. Accordingly, levels of free thiols were elevated in the culture supernatants of Jurkat cells exposed to N-succinimidyl 3-(2-pyridyldithio) propionate coupled to (Ahx) 6 MBP 85-99 via a disulphide (SPDP-S-S-(Ahx) 6 MBP 85-99 ) but returned to normal after exposure to cisplatin. These results raise the possibility of AQ-S-S-(Ahx) 6 MBP 85-99 being used as an eliminator of encephalitogenic T cells via implication of the thioredoxin system for the generation of the toxic, thiol-containing moiety (AQ-SH). Future experiments would ideally determine whether SPDP-S-S-(Ahx) 6 MBP 85-99 could incorporate into HLA II DRB1*-1501 tetramers and neutralize encephalitogenic T cell lines sensitized to
Zipf’s law, 1/f noise, and fractal hierarchy
International Nuclear Information System (INIS)
Chen Yanguang
2012-01-01
Highlights: ► I developed a general scaling method based on hierarchies of cites. ► Hierarchy is classified into three types based on monofractal and multifractals. ► Zipf’s law can be used to estimate the capacity dimension of a multifractal set. ► I derive the self-similar hierarchy from the rank-size distribution. ► The hierarchical scaling method can be applied to the 1/f spectra. - Abstract: Fractals, 1/f noise, and Zipf’s laws are frequently observed within the natural living world as well as in social institutions, representing three signatures of complex systems. All these observations are associated with scaling laws and therefore have created much research interest in many diverse scientific circles. However, the inherent relationships between these scaling phenomena are not yet clear. In this paper, theoretical demonstration and mathematical experiments based on urban studies are employed to reveal the analogy between fractal patterns, 1/f spectra, and the Zipf distribution. First, the multifractal process empirically suggests the Zipf distribution. Second, a 1/f spectrum is mathematically identical to Zipf’s law. Third, both 1/f spectra and Zipf’s law can be converted into a self-similar hierarchy. Fourth, fractals, 1/f spectra, Zipf’s law can be rescaled with similar exponential laws and power laws. The self-similar hierarchy is a more general scaling method which can be used to unify different scaling phenomena and rules in both physical and social systems such as cities, rivers, earthquakes, fractals, 1/f noise, and rank-size distributions. The mathematical laws of this hierarchical structure can provide us with a holistic perspective of looking at complexity and complex systems.
Plasmons in strong superconductors
International Nuclear Information System (INIS)
Baldo, M.; Ducoin, C.
2011-01-01
We present a study of the possible plasmon excitations that can occur in systems where strong superconductivity is present. In these systems the plasmon energy is comparable to or smaller than the pairing gap. As a prototype of these systems we consider the proton component of Neutron Star matter just below the crust when electron screening is not taken into account. For the realistic case we consider in detail the different aspects of the elementary excitations when the proton, electron components are considered within the Random-Phase Approximation generalized to the superfluid case, while the influence of the neutron component is considered only at qualitative level. Electron screening plays a major role in modifying the proton spectrum and spectral function. At the same time the electron plasmon is strongly modified and damped by the indirect coupling with the superfluid proton component, even at moderately low values of the gap. The excitation spectrum shows the interplay of the different components and their relevance for each excitation modes. The results are relevant for neutrino physics and thermodynamical processes in neutron stars. If electron screening is neglected, the spectral properties of the proton component show some resemblance with the physical situation in high-T c superconductors, and we briefly discuss similarities and differences in this connection. In a general prospect, the results of the study emphasize the role of Coulomb interaction in strong superconductors.
Continuous limits for an integrable coupling system of Toda equation hierarchy
International Nuclear Information System (INIS)
Li Li; Yu Fajun
2009-01-01
In this Letter, we present an integrable coupling system of lattice hierarchy and its continuous limits by using of Lie algebra sl(4). By introducing a complex discrete spectral problem, the integrable coupling system of Toda lattice hierarchy is derived. It is shown that a new complex lattice spectral problem converges to the integrable couplings of discrete soliton equation hierarchy, which has the integrable coupling system of C-KdV hierarchy as a new kind of continuous limit.
A new multi-component hierarchy and its integrable expanding model
International Nuclear Information System (INIS)
Dong Huanhe; Liang Xiangqian
2008-01-01
A set of multi-component matrix Lie algebra is constructed, it follows that a type of new loop algebra is presented and multi-component integrable hierarchy is obtained. Furthermore, the loop algebra is expanded into a larger one and a type of integrable coupling system is worked out. As reduction of the hierarchy, some well-known hierarchy such as DNLS, KN, CLL hierarchy are established
Supersymmetric KP hierarchy in N=1 superspace and its N=2 reductions
International Nuclear Information System (INIS)
Lechtenfeld, O.; Sorin, A.
2000-01-01
A wide class of N=2 reductions of the supersymmetric KP hierarchy in N=1 superspace is described. This class includes a new N=2 supersymmetric generalization of the Toda chain hierarchy. The Lax pair representations of the bosonic and fermionic flows, local and non-local Hamiltonians, finite and infinite discrete symmetries, first two Hamiltonian structures and the recursion operator of this hierarchy are constructed. Its secondary reduction to new N=2 supersymmetric modified KdV hierarchy is discussed
A modified Toda spectral problem and its hierarchy of bi-Hamiltonian lattice equations
International Nuclear Information System (INIS)
Ma Wenxiu; Xu Xixiang
2004-01-01
Starting from a modified Toda spectral problem, a hierarchy of generalized Toda lattice equations with two arbitrary constants is constructed through discrete zero curvature equations. It is shown that the hierarchy possesses a bi-Hamiltonian structure and a hereditary recursion operator, which implies that there exist infinitely many common commuting symmetries and infinitely many common commuting conserved functionals. Two cases of the involved constants present two specific integrable sub-hierarchies, one of which is exactly the Toda lattice hierarchy
Supersymmetric KP hierarchy in N=1 superspace and its N=2 reductions
International Nuclear Information System (INIS)
Lechtenfeld, O.; Sorin, A.
1999-01-01
A wide class of N=2 reductions of the supersymmetric KP hierarchy in N=1 superspace is described. This class includes a new N=2 supersymmetric generalization of the Toda chain hierarchy. The Lax pair representations of the bosonic and fermionic flows, local and nonlocal Hamiltonians, finite and infinite discrete symmetries, first two Hamiltonian structures and the recursion operator of this hierarchy are constructed. Its secondary reduction to new N=2 supersymmetric modified KdV hierarchy is discussed
Hierarchies of multi-component mKP equations and theirs integrable couplings
International Nuclear Information System (INIS)
Ji Jie; Yao Yuqin; Zhu Fubo; Chen Dengyuan
2008-01-01
First, a new multi-component modified Kadomtsev-Petviashvill (mKP) spectral problem is constructed by k-constraint imposed on a general pseudo-differential operator. Then, two hierarchies of multi-component mKP equations are derived, including positive non-isospectral mKP hierarchy and negative non-isospectral mKP hierarchy. Moreover, new integrable couplings of the resulting mKP soliton hierarchies are constructed by enlarging the associated matrix spectral problem
A generalized Tu formula and Hamiltonian structures of fractional AKNS hierarchy
International Nuclear Information System (INIS)
Wu, Guo-cheng; Zhang, Sheng
2011-01-01
In this Letter, a generalized Tu formula is firstly presented to construct Hamiltonian structures of fractional soliton equations. The obtained results can be reduced to the classical Hamiltonian hierarchy of AKNS in ordinary calculus. -- Highlights: → A generalized Tu formula is first established based on the fractional variational theory for non-differentiable functions. → Hamiltonian structures of fractional AKNS hierarchy are obtained. → The classical AKNS hierarchy is just a special case of the fractional hierarchy.
An integrable coupling system of lattice hierarchy and its continuous limits
International Nuclear Information System (INIS)
Yu Fajun; Li Li
2009-01-01
In [E.G. Fan, Phys. Lett. A 372 (2008) 6368], Fan present a lattice hierarchy and its continuous limits. In this Letter, we extend this method, by introducing a complex discrete spectral problem, a coupling lattice hierarchy is derived. It is shown that a new sequence of combinations of complex lattice spectral problem converges to the integrable coupling couplings of soliton equation hierarchy, which has the integrable coupling system of AKNS hierarchy as a continuous limit.
A generalized Tu formula and Hamiltonian structures of fractional AKNS hierarchy
Energy Technology Data Exchange (ETDEWEB)
Wu, Guo-cheng, E-mail: wuguocheng2002@yahoo.com.cn [Key Laboratory of Numerical Simulation of Sichuan Province, Neijiang, Sichuan 641112 (China); College of Mathematics and Information Science, Neijiang Normal University, Neijiang, Sichuan 641112 (China); Zhang, Sheng, E-mail: zhshaeng@yahoo.com.cn [School of Mathematical Sciences, Dalian University of Technology, Dalian 116024 (China)
2011-10-03
In this Letter, a generalized Tu formula is firstly presented to construct Hamiltonian structures of fractional soliton equations. The obtained results can be reduced to the classical Hamiltonian hierarchy of AKNS in ordinary calculus. -- Highlights: → A generalized Tu formula is first established based on the fractional variational theory for non-differentiable functions. → Hamiltonian structures of fractional AKNS hierarchy are obtained. → The classical AKNS hierarchy is just a special case of the fractional hierarchy.
Continuous limits for an integrable coupling system of Toda equation hierarchy
Energy Technology Data Exchange (ETDEWEB)
Li Li [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China); Yu Fajun, E-mail: yfajun@163.co [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China)
2009-09-21
In this Letter, we present an integrable coupling system of lattice hierarchy and its continuous limits by using of Lie algebra sl(4). By introducing a complex discrete spectral problem, the integrable coupling system of Toda lattice hierarchy is derived. It is shown that a new complex lattice spectral problem converges to the integrable couplings of discrete soliton equation hierarchy, which has the integrable coupling system of C-KdV hierarchy as a new kind of continuous limit.
On the physical interpretation and the mathematical structure of the combinatorial hierarchy
International Nuclear Information System (INIS)
Bastin, T.; Noyes, H.P.; Amson, J.; Kilmister, C.W.
1979-01-01
A physical interpretation of the combinatorial hierarchy model for basic particle processes. This is based on elementary entities; any representation they may have is discrete and two-valued. There are here called 'Schnurs' to suggest their most fundamental aspect as concatenating strings. On this basis a model is described which generates four hierarchical levels of increasing complexity. Details of the general principles, construction and levels are given. The original coincidence between the cardinals of the hierarchy and the inverse boson field coupling constants lead to the belief that strong, electromagnetic and gravitational phenomena have been unified in one framework. The weak decay instability is also indicated. The absolute conservation laws are brought in at the right level and points to a weak electromagnetic unification at that or the next level. Structural contact exists between SU2, SU3 and SU6 (quark) classifications including an appropriate three colour, three flavor option flexible enough to allow for new flavors and new heavy leptons. The cosmology should yield the conserved quantum numbers of the universe, some sort of 'big bang' and hence the cosmic background radiation as a unique reference system. Since the background is not time-reversal invariant, it might lead ultimately to the explanation of the Ksub(L)-Ksub(S) decay. (UK)
Bhullar, S S; Chandak, N H; Baheti, N N; Purohit, H J; Taori, G M; Daginawala, H F; Kashyap, R S
2014-01-01
Herpes simplex encephalitis (HSE) is a severe viral infection of the central nervous system (CNS). Assay of antibody response is widely used in diagnostics of HSE. The aim of this study was to identify an immunodominant epitope determining the antibody response to herpes simplex viruses (HSVs) in cerebrospinal fluid (CSF) of HSE patients. The synthetic peptides that resembled type-common as well as type-specific domains of glycoproteins B (gB) and G (gG) of these viruses were evaluated for binding with IgM and IgG antibodies in CSF samples from HSE and non-HSE patients in ELISA. The QLHDLRF peptide, derived from gB of HSV was found to be an immunodominant epitope in the IgM and IgG antibody response. The patients with confirmed and suspected HSE showed in ELISA against this peptide 26% and 23% positivities for IgM, 43% and 37% positivities for IgG and 17% and 15% for both IgM and IgG antibodies, respectively. The total positivities of 86% and 75% for both IgM and IgG antibodies were obtained in the patients with confirmed and suspected HSE, respectively. These results demonstrate that a synthetic peptide-based diagnostics of HSE can be an efficient and easily accessible alternative. This is the first report describing the use of synthetic peptides derived from HSVs in diagnostics of HSE using patientsʹ CSF samples.
International Nuclear Information System (INIS)
Guo Fukui; Zhang Yufeng
2004-01-01
A new subalgebra of loop algebra A-tilde 1 is first constructed. Then a new Lax pair is presented, whose compatibility gives rise to a new Liouville integrable system(called a major result), possessing bi-Hamiltonian structures. It is remarkable that two symplectic operators obtained in this paper are directly constructed in terms of the recurrence relations. As reduction cases of the new integrable system obtained, the famous AKNS hierarchy and the KN hierarchy are obtained, respectively. Second, we prove a conjugate operator of a recurrence operator is a hereditary symmetry. Finally, we construct a high dimension loop algebra G-bar to obtain an integrable coupling system of the major result by making use of Tu scheme. In addition, we find the major result obtained is a unified expressing integrable model of both the AKNS and KN hierarchies, of course, we may also regard the major result as an expanding integrable model of the AKNS and KN hierarchies. Thus, we succeed to find an example of expanding integrable models being Liouville integrable
Conservation laws and self-consistent sources for a super-CKdV equation hierarchy
International Nuclear Information System (INIS)
Li Li
2011-01-01
From the super-matrix Lie algebras, we consider a super-extension of the CKdV equation hierarchy in the present Letter, and propose the super-CKdV hierarchy with self-consistent sources. Furthermore, we establish the infinitely many conservation laws for the integrable super-CKdV hierarchy.
Darboux transformation and soliton solutions for the Boiti-Pempinelli-Tu (BPT) hierarchy
International Nuclear Information System (INIS)
Wang Jiong
2005-01-01
Starting from a spectral problem, we derive the well-known Boiti-Pempinelli-Tu (BPT) hierarchy. An explicit and universal Darboux transformation for the whole hierarchy is constructed. The soliton solutions for the BPT hierarchy are obtained by applying the Darboux transformation
W-algebra symmetries of generalised Drinfel'd-Sokolov hierarchies
International Nuclear Information System (INIS)
Spence, B.
1992-01-01
Using the zero curvature formulation, it is shown that W-algebra transformations are symmetries of corresponding generalised Drinfel'd-Sokolov hierarchies. This result is illustrated with the examples of the KdV and Boussinesque hierarchies, and the hierarchy associated to the Polyakov-Bershadsky W-algebra. (orig.)
Two New Reformulation Convexification Based Hierarchies for 0-1 MIPs
Directory of Open Access Journals (Sweden)
Hacene Ouzia
2015-01-01
Full Text Available First, we introduce two new reformulation convexification based hierarchies called RTC and RSC for which the rank d continuous relaxations are denoted by P^RTCd and P^RSCd, respectively. These two hierarchies are obtained using two different convexification schemes: term convexification in the case of the RTC hierarchy and standard convexification in the case of the RSC hierarchy. Secondly, we compare the strength of these two hierarchies. We will prove that (i the hierarchy RTC is equivalent to the RLT hierarchy of Sherali-Adams, (ii the hierarchy RTC dominates the hierarchy RSC, and (iii the hierarchy RSC is dominated by the Lift-and-Project hierarchy. Thirdly, for every rank d, we will prove that convTd∩Etd⊆P^RTCd⊆Td and convSd∩Esd⊆P^RSCd⊆Sd where the sets Td and Sd are convex, while Etd and Esd are two nonconvex sets with empty interior (all these sets depend on the convexification step. The first inclusions allow, in some cases, an explicit characterization (in the space of the original variables of the RLT relaxations. Finally, we will discuss weak version of both RTC and RSC hierarchies and we will emphasize some connections between them.
New Integrable Couplings of Generalized Kaup-Newell Hierarchy and Its Hamiltonian Structures
International Nuclear Information System (INIS)
Xia Tiecheng; Zhang Gailian; Fan Engui
2011-01-01
A new isospectral problem is firstly presented, then we derive integrable system of soliton hierarchy. Also we obtain new integrable couplings of the generalized Kaup-Newell soliton equations hierarchy and its Hamiltonian structures by using Tu scheme and the quadratic-form identity. The method can be generalized to other soliton hierarchy. (general)
Block (or Hamiltonian) Lie Symmetry of Dispersionless D-Type Drinfeld–Sokolov Hierarchy
International Nuclear Information System (INIS)
Li Chuan-Zhong; He Jing-Song; Su Yu-Cai
2014-01-01
In this paper, the dispersionless D-type Drinfeld–Sokolov hierarchy, i.e. a reduction of the dispersionless two-component BKP hierarchy, is studied. The additional symmetry flows of this hierarchy are presented. These flows form an infinite-dimensional Lie algebra of Block type as well as a Lie algebra of Hamiltonian type
Wronskian type solutions for the vector k-constrained KP hierarchy
International Nuclear Information System (INIS)
Zhang Youjin.
1995-07-01
Motivated by a relation of the 1-constrained Kadomtsev-Petviashvili (KP) hierarchy with the 2 component KP hierarchy, the tau-conditions of the vector k-constrained KP hierarchy are constructed by using an analogue of the Baker-Akhiezer (m + 1)-point function. These tau functions are expressed in terms of Wronskian type determinants. (author). 20 refs
Optimal City Hierarchy: A Dynamic Programming Approach to Central Place Theory
Wen-Tai Hsu; Thomas J. Holmes
2009-01-01
It is an empirically plausible description of cities and is route to explain empirical regularities in city size distribution and industrial locations. This paper formalizes central place hierarchy by providing a rationale for it via a social planner's problem. The optimal city hierarchy is then compared with the equilibrium city hierarchy in Hsu (2008).
A Discrete Spectral Problem and Related Hierarchy of Discrete Hamiltonian Lattice Equations
International Nuclear Information System (INIS)
Xu Xixiang; Cao Weili
2007-01-01
Staring from a discrete matrix spectral problem, a hierarchy of lattice soliton equations is presented though discrete zero curvature representation. The resulting lattice soliton equations possess non-local Lax pairs. The Hamiltonian structures are established for the resulting hierarchy by the discrete trace identity. Liouville integrability of resulting hierarchy is demonstrated.
Conservation laws and self-consistent sources for a super-CKdV equation hierarchy
Energy Technology Data Exchange (ETDEWEB)
Li Li, E-mail: li07099@163.co [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China)
2011-03-14
From the super-matrix Lie algebras, we consider a super-extension of the CKdV equation hierarchy in the present Letter, and propose the super-CKdV hierarchy with self-consistent sources. Furthermore, we establish the infinitely many conservation laws for the integrable super-CKdV hierarchy.
International Nuclear Information System (INIS)
Gorenstein, M. I.; Gazdzicki, M.
2011-01-01
Analysis of fluctuations of hadron production properties in collisions of relativistic particles profits from use of measurable intensive quantities which are independent of system size variations. The first family of such quantities was proposed in 1992; another is introduced in this paper. Furthermore we present a proof of independence of volume fluctuations for quantities from both families within the framework of the grand canonical ensemble. These quantities are referred to as strongly intensive ones. Influence of conservation laws and resonance decays is also discussed.
Strong-coupling approximations
International Nuclear Information System (INIS)
Abbott, R.B.
1984-03-01
Standard path-integral techniques such as instanton calculations give good answers for weak-coupling problems, but become unreliable for strong-coupling. Here we consider a method of replacing the original potential by a suitably chosen harmonic oscillator potential. Physically this is motivated by the fact that potential barriers below the level of the ground-state energy of a quantum-mechanical system have little effect. Numerically, results are good, both for quantum-mechanical problems and for massive phi 4 field theory in 1 + 1 dimensions. 9 references, 6 figures
International Nuclear Information System (INIS)
Zhang Yufeng
2005-01-01
A set of multi-component matrix Lie algebra is constructed, which is devote to obtaining a new loop algebra A-bar M-1 . It follows that an isospectral problem is established. By making use of Tu scheme, a Liouville integrable multi-component hierarchy of soliton equations is generated, which possesses the bi-Hamiltonian structures. As its reduction cases, the multi-component AKNS hierarchy and the formalism of the multi-component BPT hierarchy are given, respectively
Strongly disordered superconductors
International Nuclear Information System (INIS)
Muttalib, K.A.
1982-01-01
We examine some universal effects of strong non-magnetic disorder on the electron-phonon and electron-electron interactions in a superconductor. In particular we explicitly take into account the effect of slow diffusion of electrons in a disordered medium by working in an exact impurity eigenstate representation. We find that the normal diffusion of electrons characterized by a constant diffusion coefficient does not lead to any significant correction to the electron-phonon or the effective electron-electron interactions in a superconductor. We then consider sufficiently strong disorder where Anderson localization of electrons becomes important and determine the effect of localization on the electron-electron interactions. We find that due to localization, the diffusion of electrons becomes anomalous in the sense that the diffusion coefficient becomes scale dependent. This results in an increase in the effective electron-electron interaction with increasing disorder. We propose that this provides a natural explanation for the unusual sensitivity of the transition temperature T/sub c/ of the high T/sub c/ superconductors (T/sub c/ > 10 0 K) to damage effects
Dvali, Gia
2009-01-01
We show that whenever a 4-dimensional theory with N particle species emerges as a consistent low energy description of a 3-brane embedded in an asymptotically-flat (4+d)-dimensional space, the holographic scale of high-dimensional gravity sets the strong coupling scale of the 4D theory. This connection persists in the limit in which gravity can be consistently decoupled. We demonstrate this effect for orbifold planes, as well as for the solitonic branes and string theoretic D-branes. In all cases the emergence of a 4D strong coupling scale from bulk holography is a persistent phenomenon. The effect turns out to be insensitive even to such extreme deformations of the brane action that seemingly shield 4D theory from the bulk gravity effects. A well understood example of such deformation is given by large 4D Einstein term in the 3-brane action, which is known to suppress the strength of 5D gravity at short distances and change the 5D Newton's law into the four-dimensional one. Nevertheless, we observe that the ...
Hierarchy of non-glucose sugars in Escherichia coli.
Aidelberg, Guy; Towbin, Benjamin D; Rothschild, Daphna; Dekel, Erez; Bren, Anat; Alon, Uri
2014-12-24
Understanding how cells make decisions, and why they make the decisions they make, is of fundamental interest in systems biology. To address this, we study the decisions made by E. coli on which genes to express when presented with two different sugars. It is well-known that glucose, E. coli's preferred carbon source, represses the uptake of other sugars by means of global and gene-specific mechanisms. However, less is known about the utilization of glucose-free sugar mixtures which are found in the natural environment of E. coli and in biotechnology. Here, we combine experiment and theory to map the choices of E. coli among 6 different non-glucose carbon sources. We used robotic assays and fluorescence reporter strains to make precise measurements of promoter activity and growth rate in all pairs of these sugars. We find that the sugars can be ranked in a hierarchy: in a mixture of a higher and a lower sugar, the lower sugar system shows reduced promoter activity. The hierarchy corresponds to the growth rate supported by each sugar- the faster the growth rate, the higher the sugar on the hierarchy. The hierarchy is 'soft' in the sense that the lower sugar promoters are not completely repressed. Measurement of the activity of the master regulator CRP-cAMP shows that the hierarchy can be quantitatively explained based on differential activation of the promoters by CRP-cAMP. Comparing sugar system activation as a function of time in sugar pair mixtures at sub-saturating concentrations, we find cases of sequential activation, and also cases of simultaneous expression of both systems. Such simultaneous expression is not predicted by simple models of growth rate optimization, which predict only sequential activation. We extend these models by suggesting multi-objective optimization for both growing rapidly now and preparing the cell for future growth on the poorer sugar. We find a defined hierarchy of sugar utilization, which can be quantitatively explained by
ZHANG, JIAO
2016-01-01
[Abstract]This paper aims to discuss the necessity to advance disclosing fair value by hierarchy in Japan by reviewing the literature about fair value hierarchy information in the U.S. In Japan, ASBJ published the Exposure Draft "Accounting Standards on Fair Value Measurement and Disclosure" in 2010 which specifies that the fair value should be reported by hierarchy. However, it has not published as formal standard until March 2016. Furthermore, some commenters suggested that the hierarchy an...
Antonella Del Rosso
2016-01-01
Twenty years of designing, building and testing a number of innovative technologies, with the strong belief that the endeavour would lead to a historic breakthrough. The Bulletin publishes an abstract of the Courier’s interview with Barry Barish, one of the founding fathers of LIGO. The plots show the signals of gravitational waves detected by the twin LIGO observatories at Livingston, Louisiana, and Hanford, Washington. (Image: Caltech/MIT/LIGO Lab) On 11 February, the Laser Interferometer Gravitational-Wave Observatory (LIGO) and Virgo collaborations published a historic paper in which they showed a gravitational signal emitted by the merger of two black holes. These results come after 20 years of hard work by a large collaboration of scientists operating the two LIGO observatories in the US. Barry Barish, Linde Professor of Physics, Emeritus at the California Institute of Technology and former Director of the Global Design Effort for the Internat...
Strongly interacting Higgs bosons
International Nuclear Information System (INIS)
Appelquist, T.; Bernard, C.
1980-01-01
The sensitivity of present-energy weak interactions to a strongly interacting heavy-Higgs-boson sector is discussed. The gauged nonlinear sigma model, which is the limit of the linear model as the Higgs-boson mass goes to infinity, is used to organize and catalogue all possible heavy-Higgs-boson effects. As long as the SU(2)/sub L/ x SU(2)/sub R/ symmetry of the Higgs sector is preserved, these effects are found to be small, of the order of the square of the gauge coupling times logarithms (but not powers) of the Higgs-boson mass divided by the W mass. We work in the context of a simplified model with gauge group SU(2)/sub L/; the extension to SU(2)/sub L/ x U(1) is briefly discussed
Social Hierarchies, Economic Inequalities and Interpersonal Relationships: An Overview from India
Directory of Open Access Journals (Sweden)
Sony Pellissery
2008-12-01
Full Text Available Abject mass poverty is of the key feature of Indian subcontinent. The relationship question, in this paper, is viewed through the lenses of poverty. Thus, the spatial, political, societal and economic questions come to picture when relationships are examined through the eyes of the poor people. Face-to-face interaction, primarily, based on strong social group collective identity is the key hallmark of relationships in India. The social group identity brings hierarchy into the interaction patterns. Thus, even market relations are not merely based on the questions of economic incentives. Social identity deeply penetrates to the huge informal economy that permeates in India. Thus, caught in the web of relationships even at market sphere, the poor people come together to fight, protest and to collaborate for their own well-being.
Quasifixed points from scalar sequestering and the little hierarchy problem in supersymmetry
Martin, Stephen P.
2018-02-01
In supersymmetric models with scalar sequestering, superconformal strong dynamics in the hidden sector suppresses the low-energy couplings of mass dimension 2, compared to the squares of the dimension-1 parameters. Taking into account restrictions on the anomalous dimensions in superconformal theories, I point out that the interplay between the hidden and visible sector renormalizations gives rise to quasifixed point running for the supersymmetric Standard Model squared mass parameters, rather than driving them to 0. The extent to which this dynamics can ameliorate the little hierarchy problem in supersymmetry is studied. Models of this type in which the gaugino masses do not unify are arguably more natural, and are certainly more likely to be accessible, eventually, to the Large Hadron Collider.
ANALYTIC HIERARCHY PROCESS (AHP UNTUK PENENTUAN RANGKING PENGGUNAAN LAHAN
Directory of Open Access Journals (Sweden)
Anita Theresia Kurniawati
2017-09-01
Full Text Available In urban spatial planning, the Local Government prioritizes land use to support planning development. The use of available land in an area must be adjusted to the function. So far, sometimes in an area the use of available land in an area does not fit with its function. Therefore, in this research will be determined the priority and ranking of land use by using Analytic Hierarchy Process (AHP. Ranking is based on four aspect criterias: social demography, economic, spatial and regional plan (RTRW, and environmental aspect. Based on the alternatives and criteria and also subcriteria, the decision hierarchy model is made. Then it will be assessed for the comparison between criterias and subcriterias and their consistency value. The result is achieved by using Expert Choice software version 11 and analysis, it showed that the main priority of land allocation in Sidoarjo regency was used as agricultural land (31.9%.
Modeling rises and falls in money addicted social hierarchies
Dybiec, Bartłomiej; Mitarai, Namiko; Sneppen, Kim
2014-08-01
The emergence of large communities is inherently associated with the creation of social structures. Connections between individuals are indispensable for cooperative action of agents building social groups. Moreover, social groups usually evolve and their structure changes over time. Consequently, an underlying network connecting individuals is not static, reflecting an ongoing adaptation to new conditions. The evolution of social connections is influenced by the relative position (hierarchy) of individuals building the system as well as by the availability of resources. We explore this aspect of human ambition by modeling the interplay of social networking and an uneven distribution of external resources. The model naturally generates social hierarchies. Remarkably, this social structure exhibits a rise-and-fall behavior. A well pronounced quasi-periodic dynamics, which is closely associated with the dissipation of resources that are needed to sustain the social links, is revealed.
Optimizing an immersion ESL curriculum using analytic hierarchy process.
Tang, Hui-Wen Vivian
2011-11-01
The main purpose of this study is to fill a substantial knowledge gap regarding reaching a uniform group decision in English curriculum design and planning. A comprehensive content-based course criterion model extracted from existing literature and expert opinions was developed. Analytical hierarchy process (AHP) was used to identify the relative importance of course criteria for the purpose of tailoring an optimal one-week immersion English as a second language (ESL) curriculum for elementary school students in a suburban county of Taiwan. The hierarchy model and AHP analysis utilized in the present study will be useful for resolving several important multi-criteria decision-making issues in planning and evaluating ESL programs. This study also offers valuable insights and provides a basis for further research in customizing ESL curriculum models for different student populations with distinct learning needs, goals, and socioeconomic backgrounds. Copyright © 2011 Elsevier Ltd. All rights reserved.
Why we live in hierarchies? a quantitative treatise
Zafeiris, Anna
2018-01-01
This book systematically interprets and documents new, unifying principles and basic laws describing the most relevant aspects of hierarchy. To do so, it discusses recent experiments and models that are simple and realistic enough to reproduce the observations, and develops concepts for a better understanding of the complexity of systems consisting of many organisms. The book covers systems ranging from flocks of birds to groups of people. Although it focuses on hierarchical collective behavior in general, two aspects pop up in the majority of cases: collective motion and dynamically changing, partially directed networks (and the natural relation between the two). In addition, it offers a brief description of the most relevant definitions and concepts involved in the context of hierarchies, presenting both a review of the current literature and a number of new experimental and computational results in more detail. It is a valuable resource for students and scholars pursuing research on the structure of in...
Modeling rises and falls in money addicted social hierarchies
International Nuclear Information System (INIS)
Dybiec, Bartłomiej; Mitarai, Namiko; Sneppen, Kim
2014-01-01
The emergence of large communities is inherently associated with the creation of social structures. Connections between individuals are indispensable for cooperative action of agents building social groups. Moreover, social groups usually evolve and their structure changes over time. Consequently, an underlying network connecting individuals is not static, reflecting an ongoing adaptation to new conditions. The evolution of social connections is influenced by the relative position (hierarchy) of individuals building the system as well as by the availability of resources. We explore this aspect of human ambition by modeling the interplay of social networking and an uneven distribution of external resources. The model naturally generates social hierarchies. Remarkably, this social structure exhibits a rise-and-fall behavior. A well pronounced quasi-periodic dynamics, which is closely associated with the dissipation of resources that are needed to sustain the social links, is revealed. (paper)
Gauge hierarchy in an SO(10) supersymmetric grand unified model
International Nuclear Information System (INIS)
Zhiyong, Z.
1982-01-01
An SO(10) supersymmetric grand unified model is constructed in which the gauge hierarchy problem may be solved. Using Higgs superfields belonging to the SO(10) representations 16, 10 and 54, it is found that if SO(10) is broken down to SU(3)sub(c)xSU(2)sub(L)xU(1) via SO(6)xSO(4)approximately equal to SU(4)sub(c)xSU(2)sub(L)xSU(2)sub(R) at unification mass scales without supersymmetry breaking, the gauge hierarchy puzzle might be carried away. It is also shown that the colour-triplet Higgs, which mediates proton decay, is superheavy by an incredibly accurate, but 'natural' adjustment of parameters in the potential. (author)
Headwater biodiversity among different levels of stream habitat hierarchy
DEFF Research Database (Denmark)
Göthe, Emma; Friberg, Nikolai; Kahlert, Maria
2014-01-01
of a- and b-diversity to y-diversity between two levels of stream habitat hierarchy (catchment and region level). The relationship between species community structure and local environmental factors was also assessed. Our results show that both a- and b-diversity made a significant contribution to y......-diversity. b-diversity remained relatively constant between the two levels of habitat hierarchy even though local environmental control of the biota decreased from the catchment to the region level. To capture most of headwater y-diversity, management should therefore target sites that are locally diverse......, but at the same time select sites so that b-diversity is maximized. As environmental control of the biota peaked at the catchment level, the conservation of headwater stream diversity is likely to be most effective when management targets environmental conditions across multiple local sites within relatively...
PINGU and the neutrino mass hierarchy: Statistical and systematical aspects
International Nuclear Information System (INIS)
Capozzi, F.; Marrone, A.; Lisi, E.
2016-01-01
The proposed PINGU project (Precision IceCube Next Generation Upgrade) is supposed to determine neutrino mass hierarchy through matter effects of atmospheric neutrinos crossing the Earth core and mantle, which leads to variations in the events spectrum in energy and zenith angle. The presence of non-negligible (and partly unknown) systematics on the spectral shape can make the statistical analysis particularly challenging in the limit of high statistics. Assuming plausible spectral shape uncertainties at the percent level (due to effective volume, cross section, resolution functions, oscillation parameters, etc.), we obtain a significant reduction in the sensitivity to the hierarchy. The obtained results show the importance of a dedicated research program aimed at a better characterization and reduction of the uncertainties in future high-statistics experiments with atmospheric neutrinos.
Neural basis of preference for human social hierarchy versus egalitarianism.
Chiao, Joan Y; Mathur, Vani A; Harada, Tokiko; Lipke, Trixie
2009-06-01
A fundamental way that individuals differ is in the degree to which they prefer social dominance hierarchy over egalitarianism as a guiding principle of societal structure, a phenomenon known as social dominance orientation. Here we show that preference for hierarchical rather than egalitarian social relations varies as a function of neural responses within left anterior insula and anterior cingulate cortices. Our findings provide novel evidence that preference for social dominance hierarchy is associated with neural functioning within brain regions that are associated with the ability to share and feel concern for the pain of others; this suggests a neurobiological basis for social and political attitudes. Implications of these findings for research on the social neuroscience of fairness, justice, and intergroup relations are discussed.
Lipopolysaccharide administration in the dominant mouse destabilizes social hierarchy.
Cohn, Daniel Wagner Hamada; Gabanyi, Ilana; Kinoshita, Denise; de Sá-Rocha, Luiz Carlos
2012-09-01
Sickness behavior is a set of behavioral changes that are part of an adaptive strategy to overcome infection. Mice that interact with conspecifics displaying sickness behavior also show relevant behavioral changes. In this work we sought to determine the role of sickness behavior display by a dominant mouse as a promoter of hierarchy instability. We treated the dominant mouse within a dyad with lipopolysaccharide (LPS) (400 μg/kg, i.p.) for three consecutive days and assessed social dominance behavior. Since elder animals display increased inflammatory responses and the behaviors toward conspecifics are influenced by kinship we also assessed whether kinship and age, might influence sickness related hierarchy instability. Our results show that administration of LPS in the dominant mouse promotes social instability within a dyad, and indicates that this instability could be influenced by kinship and age. Copyright © 2012 Elsevier B.V. All rights reserved.
A New Riemann Type Hydrodynamical Hierarchy and its Integrability Analysis
International Nuclear Information System (INIS)
Golenia, Jolanta Jolanta; Bogolubov, Nikolai N. Jr.; Popowicz, Ziemowit; Pavlov, Maxim V.; Prykarpatsky, Anatoliy K.
2009-12-01
Short-wave perturbations in a relaxing medium, governed by a special reduction of the Ostrovsky evolution equation, and later derived by Whitham, are studied using the gradient-holonomic integrability algorithm. The bi-Hamiltonicity and complete integrability of the corresponding dynamical system is stated and an infinite hierarchy of commuting to each other conservation laws of dispersive type are found. The well defined regularization of the model is constructed and its Lax type integrability is discussed. A generalized hydrodynamical Riemann type system is considered, infinite hierarchies of conservation laws, related compatible co-symplectic structures and Lax type representations for the special cases N = 2, 3 and N = 4 are constructed. (author)
The family mass hierarchy problem in bosonic technicolor
International Nuclear Information System (INIS)
Kagan, A.; Samuel, S.
1990-01-01
We use a multiple Higgs system to analyze the family mass hierarchy problem in bosonic technicolor. Dependence on a wide range of Yukawa couplings, λ, for quark and lepton mass generation is greatly reduced, i.e., λ ≅ 0.1 to 1. Third and second generation masses are produced at tree-level, the latter via a see-saw mechanism. We use radiative corrections as a source for many mixing angles and first generation masses. A hierarchy of family masses with small of-diagonal Kobayashi-Maskawa entries naturally arises. A higher scale of 1-10 TeV for Higgs masses and supersymmetry breaking is needed to alleviate difficulties with flavor-changing effects. Such a large scale is a feature of bosonic technicolor and no fine-tuning is required to obtain electroweak breaking at ≅ 100 GeV. Bosonic technicolor is therefore a natural framework for multi-Higgs systems. (orig.)
Signatures of the neutrino mass hierarchy in supernova neutrinos
International Nuclear Information System (INIS)
Chiu, S.H.; Huang, Chu-Ching; Lai, Kwang-Chang
2015-01-01
The undetermined neutrino mass hierarchy may leave an observable imprint on the neutrino fluxes from a core-collapse supernova (SN). The interpretation of the observables, however, is subject to the uncertain SN models and the flavor conversion mechanism of neutrinos in a SN. We attempt to propose a qualitative interpretation of the expected neutrino events at terrestrial detectors, focusing on the accretion phase of the neutrino burst. The flavor conversions due to neutrino self-interaction, the MSW effect, and the Earth regeneration effect are incorporated in the calculation. It leads to several distinct scenarios that are identified by the neutrino mass hierarchies and the collective flavor transitions. Consequences resulting from the variation of incident angles and SN models are also discussed
Identifying the neutrino mass hierarchy with supernova neutrinos
International Nuclear Information System (INIS)
Tomas, Ricard
2006-01-01
We review how a high-statistics observation of the neutrino signal from a future galactic core-collapse supernova (SN) may be used to discriminate between different neutrino mixing scenarios. We discuss two complementary methods that allow for the positive identification of the mass hierarchy without knowledge of the emitted neutrino fluxes, provided that the 13-mixing angle is large, sin 2 θ 13 -5 . These two approaches are the observation of modulations in the neutrino spectra by Earth matter effects or by the passage of shock waves through the SN envelope. If the value of the 13-mixing angle is unknown, using additionally the information encoded in the prompt neutronization ν e burst-a robust feature found in all modern SN simulations-can be sufficient to fix both the neutrino hierarchy and to decide whether θ 13 is 'small' or 'large'
Toward a Strongly Interacting Scalar Higgs Particle
International Nuclear Information System (INIS)
Shalaby, Abouzeid M.; El-Houssieny, M.
2008-01-01
We calculate the vacuum energy of the non-Hermitian and PT symmetric (-gφ 4 ) 2+1 scalar field theory. Rather than the corresponding Hermitian theory and due to the asymptotic freedom property of the theory, the vacuum energy does not blow up for large energy scales which is a good sign to solve the hierarchy problem when using this model to break the U(1)xSU(2) symmetry in the standard model. The theory is strongly interacting and in fact, all the dimensionful parameters in the theory like mass and energy are finite even for very high energy scales. Moreover, relative to the vacuum energy for the Hermitian φ 4 theory, the vacuum energy of the non-Hermitian and PT symmetric (-gφ 4 ) 2+1 theory is tiny, which is a good sign toward the solution of the cosmological constant problem. Remarkably, these features of the non-Hermitian and PT symmetric (-gφ 4 ) 2+1 scalar field theory make it very plausible to be employed as a Higgs mechanism in the standard model instead of the problematic Hermitian Higgs mechanism
Sato theory on the q-Toda hierarchy and its extension
International Nuclear Information System (INIS)
Li, Chuanzhong
2015-01-01
In this paper, we construct the Sato theory including the Hirota bilinear equations and tau function of a new q-deformed Toda hierarchy (QTH). Meanwhile the Block type additional symmetry and bi-Hamiltonian structure of this hierarchy are given. From Hamiltonian tau symmetry, we give another definition of tau function of this hierarchy. Afterwards, we extend the q-Toda hierarchy to an extended q-Toda hierarchy (EQTH) which satisfy a generalized Hirota quadratic equation in terms of generalized vertex operators. The Hirota quadratic equation might have further application in Gromov–Witten theory. The corresponding Sato theory including multi-fold Darboux transformations of this extended hierarchy is also constructed. At last, we construct the multicomponent extension of the q-Toda hierarchy and show the integrability including its bi-Hamiltonian structure, tau symmetry and conserved densities
Solutions to higher hamiltonians in the Toda hierarchies
International Nuclear Information System (INIS)
Ferreira, L.A.; Londe, R.M.
1988-01-01
We present a method for constructing the general solution to higher hamiltonians of the Toda hierarchies of integrable models associated to a simple Lie group G. The method depends on some special properties of the representations of the Lie algebra of G and it constitutes a generalization of the method used to construct the solutions of the Toda Molecula models. The SL(3) and SL(4) cases are discussed in detail. (author) [pt
Strings and extra dimensions: Mass hierarchies and experimental signatures
Directory of Open Access Journals (Sweden)
Antoniadis I.
2014-04-01
Full Text Available Lowering the string scale in the TeV region provides a theoretical framework for solving the mass hierarchy problem and unifying all interactions. The apparent weakness of gravity can then be accounted by the existence of large internal dimensions, in the submillimeter region, and transverse to a braneworld where our universe must be confined. I review the main properties of this scenario and its experimental implications.
Structural hierarchy of autism spectrum disorder symptoms: an integrative framework.
Kim, Hyunsik; Keifer, Cara M; Rodriguez-Seijas, Craig; Eaton, Nicholas R; Lerner, Matthew D; Gadow, Kenneth D
2018-01-01
In an attempt to resolve questions regarding the symptom classification of autism spectrum disorder (ASD), previous research generally aimed to demonstrate superiority of one model over another. Rather than adjudicating which model may be optimal, we propose an alternative approach that integrates competing models using Goldberg's bass-ackwards method, providing a comprehensive understanding of the underlying symptom structure of ASD. The study sample comprised 3,825 individuals, consecutive referrals to a university hospital developmental disabilities specialty clinic or a child psychiatry outpatient clinic. This study analyzed DSM-IV-referenced ASD symptom statements from parent and teacher versions of the Child and Adolescent Symptom Inventory-4R. A series of exploratory structural equation models was conducted in order to produce interpretable latent factors that account for multivariate covariance. Results indicated that ASD symptoms were structured into an interpretable hierarchy across multiple informants. This hierarchy includes five levels; key features of ASD bifurcate into different constructs with increasing specificity. This is the first study to examine an underlying structural hierarchy of ASD symptomatology using the bass-ackwards method. This hierarchy demonstrates how core features of ASD relate at differing levels of resolution, providing a model for conceptualizing ASD heterogeneity and a structure for integrating divergent theories of cognitive processes and behavioral features that define the disorder. These findings suggest that a more coherent and complete understanding of the structure of ASD symptoms may be reflected in a metastructure rather than at one level of resolution. © 2017 Association for Child and Adolescent Mental Health.
On the Hierarchy of Functioning Rules in Distributed Computing
Bui , Alain; Bui , Marc; Lavault , Christian
1999-01-01
International audience; In previous papers, we used a Markovian model to determine the optimal functioning rules of a distributed system in various settings. Searching optimal functioning rules amounts to solve an optimization problem under constraints. The hierarchy of solutions arising from the above problem is called the “first order hierarchy”, and may possibly yield equivalent solutions. The present paper emphasizes a specific technique for deciding between two equivalent solutions, whic...
Needs Hierarchy, Motivational Factors and Entrepreneurship in Bangladesh
Mostofa Haque
2010-01-01
Every human being is driven by his/her desire to reach his/her needs, whereby the needs evolve to more ambitious needs once the most fundamental needs have been achieved. To reach more ambitious needs, accommodating socio-economic infrastructures and appropriate government support are required. Based on various surveys, this paper examines the needs hierarchy of Bangladeshi people as well as the main hindrances for not reaching higher up needs in Bangladesh. It analyzes the motivational facto...
Borel hierarchies in infinite products of Polish spaces
Indian Academy of Sciences (India)
with two product topologies: (i) the product of copies of the Polish topology on X, so that H is again a Polish space and (ii) the product of copies of the discrete topology on X. Define now the Borel hierarchy in the larger topology on H. To do so, we need some notation. An element of H will be denoted by h = (x1,x2,...,xn,.
A hierarchy of intrinsic timescales across primate cortex.
Murray, John D; Bernacchia, Alberto; Freedman, David J; Romo, Ranulfo; Wallis, Jonathan D; Cai, Xinying; Padoa-Schioppa, Camillo; Pasternak, Tatiana; Seo, Hyojung; Lee, Daeyeol; Wang, Xiao-Jing
2014-12-01
Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal areas exhibiting shorter and longer timescales, respectively. On the basis of our findings, we suggest that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges.
Social network and dominance hierarchy analyses at Chimpanzee Sanctuary Northwest.
Directory of Open Access Journals (Sweden)
Jake A Funkhouser
Full Text Available Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relationships, dominance hierarchy, and social network diagrams can be useful in advising current management practices in sanctuaries and other captive settings. In this study, we investigated the dyadic social relationships, group-level social networks, and dominance hierarchy of seven chimpanzees (Pan troglodytes at Chimpanzee Sanctuary Northwest. We used focal-animal and instantaneous scan sampling to collect 106.75 total hours of associative, affiliative, and agonistic data from June to September 2016. We analyzed our data using SOCPROG to derive dominance hierarchies and network statistics, and we diagrammed the group's social networks in NetDraw. Three individuals were most central in the grooming network, while two others had little connection. Through agonistic networks, we found that group members reciprocally exhibited agonism, and the group's dominance hierarchy was statistically non-linear. One chimpanzee emerged as the most dominant through agonism but was least connected to other group members across affiliative networks. Our results indicate that the conventional methods used to calculate individuals' dominance rank may be inadequate to wholly depict a group's social relationships in captive sanctuary populations. Our results have an applied component that can aid sanctuary staff in a variety of ways to best ensure the improvement of group welfare.
Maslow’s hierarchy of needs: An Islamic critique
Anke Iman Bouzenita; Aisha Wood Boulanouar
2016-01-01
Abraham Maslow’s model of the hierarchy of needs is pervasive in many academic specialisations. After a short description of the model, this article summarises the existing criticisms. While criticism on the empirical validity of the model and its ethno-centricity are frequently mentioned in the literature, the authors of this article give special focus on the missing consideration of the spiritual aspect of human existence in Maslow’s model. The study explores reasons for the commodification...
Combining semantics with non-standard interpreter hierarchies
DEFF Research Database (Denmark)
Abramov, Sergei M.; Glück, Robert
2000-01-01
This paper reports on results concerning the combination of non-standard semantics via interpreters. We define what a semantics combination means and identify under which conditions a combination can be realized by computer programs (robustness, safely combinable). We develop the underlying mathe...... mathematical theory and examine the meaning of several non-standard interpreter towers. Our results suggest a technique for the implementation of a certain class of programming language dialects by composing a hierarchy of non-standard interpreters....
The hierarchy problem and Physics Beyond the Standard Model
Indian Academy of Sciences (India)
boson. Without the Higgs, theory is not unitary. Gautam Bhattacharyya ... highest scale of the theory. Thus physics at several orders of ... Hu. ≃ −|μ2| + O(1) m2. ˜t mh ≃ 125 GeV ⇒ m˜t ∼ few TeV ⇒ large cancellation ⇒ little hierarchy problem. Large mt drives M. 2. Hu negative. EWSB dynamically triggered by RG. 2. 4. 6. 8.
On two-current realization of KP hierarchy
International Nuclear Information System (INIS)
Aratyn, H.; Ferreira, L.A.; Gomes, J.F.; Zimerman, A.H.
1992-06-01
A simple description of the KP hierarchy and its multi-Hamiltonian structure is given in terms of two Bose currents. A deformation scheme connecting various W-infinity algebras and relation between two fundamental nonlinear structures are discussed. Properties of Faa di Bruno polynomials are extensively explored in this construction. Applications of our method are given for the Conformal Affine Toda model, WZNW models and discrete KP approach to Toda lattice chain. (author)
Social network and dominance hierarchy analyses at Chimpanzee Sanctuary Northwest.
Funkhouser, Jake A; Mayhew, Jessica A; Mulcahy, John B
2018-01-01
Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA) is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relationships, dominance hierarchy, and social network diagrams can be useful in advising current management practices in sanctuaries and other captive settings. In this study, we investigated the dyadic social relationships, group-level social networks, and dominance hierarchy of seven chimpanzees (Pan troglodytes) at Chimpanzee Sanctuary Northwest. We used focal-animal and instantaneous scan sampling to collect 106.75 total hours of associative, affiliative, and agonistic data from June to September 2016. We analyzed our data using SOCPROG to derive dominance hierarchies and network statistics, and we diagrammed the group's social networks in NetDraw. Three individuals were most central in the grooming network, while two others had little connection. Through agonistic networks, we found that group members reciprocally exhibited agonism, and the group's dominance hierarchy was statistically non-linear. One chimpanzee emerged as the most dominant through agonism but was least connected to other group members across affiliative networks. Our results indicate that the conventional methods used to calculate individuals' dominance rank may be inadequate to wholly depict a group's social relationships in captive sanctuary populations. Our results have an applied component that can aid sanctuary staff in a variety of ways to best ensure the improvement of group welfare.
Analytic Hierarchy Process Expansion for Innovation Performance Measurement Framework
Directory of Open Access Journals (Sweden)
Song-Kyoo Kim
2013-01-01
Full Text Available Innovation is a top strategic priority for the majority of companies. The need for innovation becomes more and more evident in the current corporate world, and the purpose of innovation is to create business value. The Analytic Hierarchy Process (AHP is a structured technique for organizing and analyzing complex decisions. This paper is targeting the framework design of the innovation performance criteria and provides the general guidelines to evaluate the relationship between the criteria by using AHP expansion.
Physical Principles of Discrete Hierarchies Formation in Protein Macromolecules
Malyshko, E. V.; Tverdislov, V. A.
2017-11-01
A model for chiral periodicity with alternating chiral sense in hierarchies of protein and nucleic acid structures is proposed and substantiated. Regular alternation of the chirality sense is revealed in transitions from the lowest to higher levels of structural-functional organization in proteins where it is L-D-L-D. The stratification principle combines the ideas of biomacromolecules folding and molecular biological machines.