WorldWideScience

Sample records for strong factor loadings

  1. Dynamical load factor of impact loaded shell structures

    International Nuclear Information System (INIS)

    Hammel, J.

    1977-01-01

    Dynamical loaded structures can be analysed by spectral representations, which usually lead to an enormous computational effort. If it is possible to find a fitting dynamical load factor, the dynamical problem can be reduced to a statical one. The computation of this statical problem is much simpler. The disadvantage is that the dynamical load factor usually leads to a very rough approximation. In this paper it will be shown, that by combination of these two methods, the approximation of the dynamical load factor can be improved and the consumption of computation time can be enormously reduced. (Auth.)

  2. Perceptual load corresponds with factors known to influence visual search.

    Science.gov (United States)

    Roper, Zachary J J; Cosman, Joshua D; Vecera, Shaun P

    2013-10-01

    One account of the early versus late selection debate in attention proposes that perceptual load determines the locus of selection. Attention selects stimuli at a late processing level under low-load conditions but selects stimuli at an early level under high-load conditions. Despite the successes of perceptual load theory, a noncircular definition of perceptual load remains elusive. We investigated the factors that influence perceptual load by using manipulations that have been studied extensively in visual search, namely target-distractor similarity and distractor-distractor similarity. Consistent with previous work, search was most efficient when targets and distractors were dissimilar and the displays contained homogeneous distractors; search became less efficient when target-distractor similarity increased irrespective of display heterogeneity. Importantly, we used these same stimuli in a typical perceptual load task that measured attentional spillover to a task-irrelevant flanker. We found a strong correspondence between search efficiency and perceptual load; stimuli that generated efficient searches produced flanker interference effects, suggesting that such displays involved low perceptual load. Flanker interference effects were reduced in displays that produced less efficient searches. Furthermore, our results demonstrate that search difficulty, as measured by search intercept, has little bearing on perceptual load. We conclude that rather than be arbitrarily defined, perceptual load might be defined by well-characterized, continuous factors that influence visual search. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  3. Strong factor in the SO(2,3) S matrix

    International Nuclear Information System (INIS)

    Amado, R.D.; Sparrow, D.A.

    1986-01-01

    The group theoretic S matrix of Alhassid, Iachello, and Wu is factorable into a product of Coulomb and strong factors. The strong factor is examined with a view to relating it to more fa- miliar potential and phase shift descriptions. We find simple approximate expressions for the phase shifts which are very accurate for heavy-ion-type applications. For peripheral scattering it is possible to obtain simple expressions relating the strong factor to an effective potential

  4. Load factors to end March 1989

    International Nuclear Information System (INIS)

    Howles, L.

    1989-01-01

    Load factors for nuclear reactors of 150MWe gross and above for the 12 month period up to the end of March 1989, and over their lifetimes, are tabulated. Units which have been in operation for more than one year as of end March 1989 are ranked in order of annual load factor; cumulative load factors are also shown, measured from first synchronization to the grid not from start of commercial operation. New reactors which had operated for less than 12 months as of end of March 1989 are listed separately. With the exception of the four Paks units in Hungary, Comecon reactors are excluded due to lack of data. (author)

  5. Factor structure underlying components of allostatic load.

    Directory of Open Access Journals (Sweden)

    Jeanne M McCaffery

    Full Text Available Allostatic load is a commonly used metric of health risk based on the hypothesis that recurrent exposure to environmental demands (e.g., stress engenders a progressive dysregulation of multiple physiological systems. Prominent indicators of response to environmental challenges, such as stress-related hormones, sympatho-vagal balance, or inflammatory cytokines, comprise primary allostatic mediators. Secondary mediators reflect ensuing biological alterations that accumulate over time and confer risk for clinical disease but overlap substantially with a second metric of health risk, the metabolic syndrome. Whether allostatic load mediators covary and thus warrant treatment as a unitary construct remains to be established and, in particular, the relation of allostatic load parameters to the metabolic syndrome requires elucidation. Here, we employ confirmatory factor analysis to test: 1 whether a single common factor underlies variation in physiological systems associated with allostatic load; and 2 whether allostatic load parameters continue to load on a single common factor if a second factor representing the metabolic syndrome is also modeled. Participants were 645 adults from Allegheny County, PA (30-54 years old, 82% non-Hispanic white, 52% female who were free of confounding medications. Model fitting supported a single, second-order factor underlying variance in the allostatic load components available in this study (metabolic, inflammatory and vagal measures. Further, this common factor reflecting covariation among allostatic load components persisted when a latent factor representing metabolic syndrome facets was conjointly modeled. Overall, this study provides novel evidence that the modeled allostatic load components do share common variance as hypothesized. Moreover, the common variance suggests the existence of statistical coherence above and beyond that attributable to the metabolic syndrome.

  6. 14 CFR 27.337 - Limit maneuvering load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit maneuvering load factor. 27.337... Limit maneuvering load factor. The rotorcraft must be designed for— (a) A limit maneuvering load factor... load factor not less than 2.0 and any negative limit maneuvering load factor of not less than −0.5 for...

  7. 14 CFR 29.337 - Limit maneuvering load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit maneuvering load factor. 29.337... Limit maneuvering load factor. The rotorcraft must be designed for— (a) A limit maneuvering load factor... load factor not less than 2.0 and any negative limit maneuvering load factor of not less than −0.5 for...

  8. Strong shock wave and areal mass oscillations associated with impulsive loading of planar laser targets

    International Nuclear Information System (INIS)

    Velikovich, A.L.; Schmitt, A.J.; Metzler, N.; Gardner, J.H.

    2003-01-01

    When a rippled surface of a planar target is irradiated with a short (subnanosecond) laser pulse, the shock wave launched into the target and the mass distribution of the shocked plasma will oscillate. These oscillations are found to be surprisingly strong compared, for example, to the case when the laser radiation is not turned off but rather keeps pushing the shock wave into the target. Being stronger than the areal mass oscillations due to ablative Richtmyer-Meshkov instability and feedout in planar targets, which have recently been observed at the Naval Research Laboratory (NRL) [Aglitskiy et al., Phys. Plasmas 9, 2264 (2002)], these oscillations should therefore be directly observable with the same diagnostic technique. Irradiation of a target with a short laser pulse represents a particular case of an impulsive loading, a fast release of finite energy in a thin layer near the surface of a target. Renewed interest to the impulsive loading in the area of direct-drive laser fusion is due to the recent proposals of using a short pulse prior to the drive pulse to make the target more resistant to laser imprint and Rayleigh-Taylor growth. Impulsive loading produces a shock wave that propagates into the target and is immediately followed by an expansion wave, which gradually reduces the shock strength. If the irradiated surface is rippled, then, while the shock wave propagates through the target, its modulation amplitude grows, exceeding the initial ripple amplitude by a factor of 2 or more. The oscillating areal mass reaches the peak values that exceed the initial mass modulation amplitude (density times ripple height) by a factor of 5-7 or more, and reverses its phase several times after the laser pulse is over. The oscillatory growth is more pronounced in fluids with higher shock compressibility and is probably related to the Vishniac's instability of a blast wave. Frequency of the oscillations is determined by the speed of sound in the shocked material, and

  9. The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences.

    Science.gov (United States)

    Yuan, Jing; Gao, Yanan; Wang, Xinyu; Liu, Hongzhuo; Che, Xin; Xu, Lu; Yang, Yang; Wang, Qifang; Wang, Yan; Li, Sanming

    2014-01-01

    Ion-exchange fibers were different from conventional ion-exchange resins in their non-cross-linked structure. The exchange was located on the surface of the framework, and the transport resistance reduced significantly, which might mean that the exchange is controlled by an ionic reaction instead of diffusion. Therefore, this work aimed to investigate the load and release characteristics of five model drugs with the strong cationic ion-exchange fiber ZB-1. Drugs were loaded using a batch process and released in United States Pharmacopoeia (USP) dissolution apparatus 2. Opposing exchange kinetics, suitable for the special structure of the fiber, were developed for describing the exchange process with the help of thermodynamics, which illustrated that the load was controlled by an ionic reaction. The molecular weight was the most important factor to influence the drug load and release rate. Strong alkalinity and rings in the molecular structures made the affinity between the drug and fiber strong, while logP did not cause any profound differences. The drug-fiber complexes exhibited sustained release. Different kinds and concentrations of counter ions or different amounts of drug-fiber complexes in the release medium affected the release behavior, while the pH value was independent of it. The groundwork for in-depth exploration and further application of ion-exchange fibers has been laid.

  10. 14 CFR 31.23 - Flight load factor.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flight load factor. 31.23 Section 31.23... STANDARDS: MANNED FREE BALLOONS Strength Requirements § 31.23 Flight load factor. In determining limit load, the limit flight load factor must be at least 1.4. ...

  11. Conservative flight with a varying load factor and closed form ...

    Indian Academy of Sciences (India)

    Conservative flight performance of an aircraft with constant load factor was analysed by ... Within the frame work of flat earth hypotheses the equations of motion of an aircraft as obtained by ..... load factor function if this inequality holds good.

  12. Nucleon quark structure and strong meson-nucleon form factors

    International Nuclear Information System (INIS)

    Efimov, G.V.; Ivanov, M.A.

    1987-01-01

    The nucleon is considered as a three-quark system in virton-quark model. The main statistic properties of proton and neutron are calculated: magnetic moments, electromagnetic radii, G A /G V ratio in weak neutron decay. Strong meson-nucleon form factors which determine nucleon-nucleon potential are obtained as a function of squared transfer momentum of mesons. The results are compared with phenomenological form factors used for description of phases of NN-scattering in the one-boson-, exchange model

  13. 14 CFR 398.9 - Load factor standards.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Load factor standards. 398.9 Section 398.9... STATEMENTS GUIDELINES FOR INDIVIDUAL DETERMINATIONS OF BASIC ESSENTIAL AIR SERVICE § 398.9 Load factor standards. The load factor standards used in this part may be raised for individual eligible places under...

  14. Probability based load factors for design of concrete containment structures

    International Nuclear Information System (INIS)

    Hwang, H.; Kagami, S.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper describes a procedure for developing probability-based load combinations for the design of concrete containments. The proposed criteria are in a load and resistance factor design (LRFD) format. The load factors and resistance factors are derived for use in limit states design and are based on a target limit state probability. In this paper, the load factors for accident pressure and safe shutdown earthquake are derived for three target limit state probabilities. Other load factors are recommended on the basis of prior experience with probability-based design criteria for ordinary building construction. 6 refs

  15. Xenon capture on silver-loaded zeolites: characterization of very strong adsorption sites

    International Nuclear Information System (INIS)

    Daniel, Cecile; Elbaraoui, Adnane; Aguado, Sonia; Schuurman, Yves; Farrusseng, David; Springuel-Huet, Marie-Anne; Nossov, Andrei; Fontaine, Jean-Pierre; Topin, Sylvain; Taffary, Thomas; Deliere, Ludovic

    2013-01-01

    The number and strength of adsorption sites for Xe in silver-modified zeolites are estimated from isotherm measurements at various temperatures over a broad range of pressure (from 1 ppm to atmospheric pressure). Fully and partially exchanged silver zeolites were synthesized starting from Na-ZSM-5(25), Na-ZSM-5(40), Na-Beta, NaX, and NaY. We have discovered that silver-modified zeolites may present one or two distinct adsorption sites depending on the nature of the material and silver loadings. The strongest adsorption sites are characterized by isosteric heat of adsorption in the order of -40 to -50 kJ.mol -1 . For Pentasil-type zeolites, we observe a linear 2:1 correlation between the total amount of silver and the number of strong sites. The highest concentration of strong sites is found for fully silver exchanged ZSM-5 (5.7 * 10 -4 mol/g), which presents the largest silver content for Pentasil-type zeolite. The equilibrium constant of Ag-ZSM-5 at low pressure is about 50 times larger than that of AgX. Qualitative correlations were established between Xe adsorption isotherms and Xe NMR signals. We show that Xe NMR could be used as a quantitative method for the characterization of the strength and of the number of strong Xe adsorption sites on silver-exchanged zeolites. The numbers of strong adsorption sites responsible for the Xe adsorption at 10-1000 ppm can be determined by the length of the plateau observed at low Xe uptake. In practice, our findings give guidelines for the discovery and optimization of silver-loaded zeolites for the capture of Xe at ppm levels. It appears that the amount of silver is a key parameter. Silver-modified ZSM-5 shows adsorption capacities 2-3 orders of magnitude larger than currently applied adsorbents for atmospheric Xe capture. (authors)

  16. Testing for time-varying loadings in dynamic factor models

    DEFF Research Database (Denmark)

    Mikkelsen, Jakob Guldbæk

    Abstract: In this paper we develop a test for time-varying factor loadings in factor models. The test is simple to compute and is constructed from estimated factors and residuals using the principal components estimator. The hypothesis is tested by regressing the squared residuals on the squared...... there is evidence of time-varying loadings on the risk factors underlying portfolio returns for around 80% of the portfolios....

  17. Load factor trends in light water reactor units

    International Nuclear Information System (INIS)

    Lehtinen, E.A.

    1990-01-01

    The Technical Research Centre of Finland follows up and analyses nuclear power plant availability performances worldwide. The results of a trend study for the load factors of the LWR units have been updated to the end of 1987. The whole operating history, in the sense of the annual and cumulative load factors achieved by all the Western commercial LWR units until the end of 1987, has been taken into consideration. Some trends in the load factors have been identified by using an exponential regression model developed. The LWR units form quite an inhomogeneous population with respect to their age, technical characteristics, site country as well as cumulative load factors achieved. The cumulative load factors achieved by all the LWR units until the end of 1987 are presented individually in the scattergrams

  18. Impact of measurement uncertainty from experimental load distribution factors on bridge load rating

    Science.gov (United States)

    Gangone, Michael V.; Whelan, Matthew J.

    2018-03-01

    Load rating and testing of highway bridges is important in determining the capacity of the structure. Experimental load rating utilizes strain transducers placed at critical locations of the superstructure to measure normal strains. These strains are then used in computing diagnostic performance measures (neutral axis of bending, load distribution factor) and ultimately a load rating. However, it has been shown that experimentally obtained strain measurements contain uncertainties associated with the accuracy and precision of the sensor and sensing system. These uncertainties propagate through to the diagnostic indicators that in turn transmit into the load rating calculation. This paper will analyze the effect that measurement uncertainties have on the experimental load rating results of a 3 span multi-girder/stringer steel and concrete bridge. The focus of this paper will be limited to the uncertainty associated with the experimental distribution factor estimate. For the testing discussed, strain readings were gathered at the midspan of each span of both exterior girders and the center girder. Test vehicles of known weight were positioned at specified locations on each span to generate maximum strain response for each of the five girders. The strain uncertainties were used in conjunction with a propagation formula developed by the authors to determine the standard uncertainty in the distribution factor estimates. This distribution factor uncertainty is then introduced into the load rating computation to determine the possible range of the load rating. The results show the importance of understanding measurement uncertainty in experimental load testing.

  19. An alternative method for centrifugal compressor loading factor modelling

    Science.gov (United States)

    Galerkin, Y.; Drozdov, A.; Rekstin, A.; Soldatova, K.

    2017-08-01

    The loading factor at design point is calculated by one or other empirical formula in classical design methods. Performance modelling as a whole is out of consideration. Test data of compressor stages demonstrates that loading factor versus flow coefficient at the impeller exit has a linear character independent of compressibility. Known Universal Modelling Method exploits this fact. Two points define the function - loading factor at design point and at zero flow rate. The proper formulae include empirical coefficients. A good modelling result is possible if the choice of coefficients is based on experience and close analogs. Earlier Y. Galerkin and K. Soldatova had proposed to define loading factor performance by the angle of its inclination to the ordinate axis and by the loading factor at zero flow rate. Simple and definite equations with four geometry parameters were proposed for loading factor performance calculated for inviscid flow. The authors of this publication have studied the test performance of thirteen stages of different types. The equations are proposed with universal empirical coefficients. The calculation error lies in the range of plus to minus 1,5%. The alternative model of a loading factor performance modelling is included in new versions of the Universal Modelling Method.

  20. Residential Load Manageability Factor Analyses by Load Sensitivity Affected by Temperature

    Directory of Open Access Journals (Sweden)

    N. Eskandari

    2016-12-01

    Full Text Available Load side management is the basic and significant principle to keeping the balance between generation side and consumption side of electrical power energy. Load side management on typical medium voltage feeder is the power energy consumption control of connected loads with variation of essential parameters that loads do reaction to their variation. Knowing amount of load's reaction to each parameters variation in typical medium voltage feeder during the day, leads to gain Load Manageability Factor (LMF for that specific feeder that helps power utilities to manage their connected loads. Calculating this LMF needs to find out each types of load with unique inherent features behavior to each parameters variation. This paper results and future work results will help us to catch mentioned LMF. In this paper analysis of residential load behavior due to temperature variation with training artificial neural network will be done. Load behavior due to other essential parameters variations like energy pricing variation, major event happening, and power utility announcing to the customers, and etc will study in future works. Collecting all related works results in a unit mathematical equation or an artificial neural network will gain LMF.

  1. Loading factor and inclination parameter of diagonal type MHD generators

    International Nuclear Information System (INIS)

    Ishikawa, Motoo

    1979-01-01

    Regarding diagonal type MHD generators is studied the relation between the loading factor and inclination parameter which is required for attaining the maximum power density with a given electrical efficiency on the assumption of infinitely segmented electrodes. The average current density on electrodes is calculated against the Hall parameter, loading factor, and inclination parameter. The diagonal type generator is compared with Faraday type generator regarding the average current density. Decreasing the loading factor from inlet to outlet is appropriate to small size generators but increasing to large size generators. The inclination parameter had better decrease in both generators, being smaller for small generators than for large ones. The average current density on electrodes of diagonal type generators varies less with the loading factor than the Faraday type. In large size generators its value can become smaller compared with that of the Faraday type. (author)

  2. A Flavorful Factoring of the Strong CP Problem

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Prateek [Harvard U., Phys. Dept.; Howe, Kiel [Fermilab

    2017-12-15

    Motivated by the intimate connection between the strong CP problem and the flavor structure of the Standard Model, we present a flavor model that revives and extends the classic ${m_u=0}$ solution to the strong CP problem. QCD is embedded into a $SU(3)_1\\times SU(3)_2 \\times SU(3)_3$ gauge group, with each generation of quarks charged under the respective $SU(3)$. The non-zero value of the up-quark Yukawa coupling (along with the strange quark and bottom-quark Yukawas) is generated by contributions from small instantons at a new scale $M \\gg \\Lambda_{QCD}$. The Higgsing of $SU(3)^3\\to SU(3)_c$ allows dimension-5 operators that generate the Standard Model flavor structure and can be completed in a simple renormalizable theory. The smallness of the third generation mixing angles can naturally emerge in this picture, and is connected to the smallness of threshold corrections to $\\bar\\theta$. Remarkably, $\\bar\\theta$ is essentially fixed by the measured quark masses and mixings, and is estimated to be close to the current experimental bound and well within reach of the next generation of neutron and proton EDM experiments.

  3. A Strong Case for Viral Genetic Factors in HIV Virulence

    Directory of Open Access Journals (Sweden)

    Joshua T. Herbeck

    2011-03-01

    Full Text Available HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four studies [1–4] published within a year has filled this important gap and has demonstrated a robust effect of the viral genotype on HIV virulence.

  4. Strong CP violation and the neutron electric dipole form factor

    International Nuclear Information System (INIS)

    Kuckei, J.; Dib, C.; Faessler, A.; Gutsche, T.; Kovalenko, S. G.; Lyubovitskij, V. E.; Pumsa-ard, K.

    2007-01-01

    We calculate the neutron electric dipole form factor induced by the CP-violating θ term of QCD within a perturbative chiral quark model which includes pion and kaon clouds. On this basis, we derive the neutron electric dipole moment and the electron-neutron Schiff moment. From the existing experimental upper limits on the neutron electric dipole moment, we extract constraints on the θ parameter and compare our results with other approaches

  5. Load Distribution Factors for Composite Multicell Box Girder Bridges

    Science.gov (United States)

    Tiwari, Sanjay; Bhargava, Pradeep

    2017-12-01

    Cellular steel section composite with a concrete deck is one of the most suitable superstructures in resisting torsional and warping effects induced by highway loading. This type of structure has inherently created new design problems for engineers in estimating its load distribution when subjected to moving vehicles. Indian Codes of Practice does not provide any specific guidelines for the design of straight composite concrete deck-steel multi-cell bridges. To meet the practical requirements arising during the design process, a simple design method is needed for straight composite multi-cell bridges in the form of load distribution factors for moment and shear. This work presents load distribution characteristics of straight composite multi-cell box girder bridges under IRC trains of loads.

  6. SEISMIC BEHAVIOR OF STEEL MONORAIL BRIDGES UNDER TRAIN LOAD DURING STRONG EARTHQUAKES

    OpenAIRE

    KIM, C. W.; KAWATANI, M.; KANBARA, T.; NISHIMURA, N.

    2013-01-01

    This paper investigated dynamic responses of steel monorail bridges incorporating train-bridge interaction under strong earthquakes. Two types of steel monorail bridges were considered in the study: a conventional type with steel track-girder; an advanced type with composite track-girder and simplified lateral bracing system. During strong earthquakes, monorail train was assumed standing on the track-girder of monorail bridges. Observations through the analytical study showed that considering...

  7. 14 CFR 23.527 - Hull and main float load factors.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull and main float load factors. 23.527... Water Loads § 23.527 Hull and main float load factors. (a) Water reaction load factors nw must be...=seaplane landing weight in pounds. (6) K1=empirical hull station weighing factor, in accordance with figure...

  8. Magnetic separation technique for environmental water purification by strong magnetic field generator loading HTS bulk magnets

    International Nuclear Information System (INIS)

    Oka, T.; Tanaka, K.; Kimura, T.; Mimura, D.; Fukui, S.; Ogawa, J.; Sato, T.; Ooizumi, M.; Yokoyama, K.; Yamaguchi, M.

    2010-01-01

    The magnetic separation technique in combination with high temperature superconducting bulk magnets has been investigated to purify the ground water which has been used in the coolant system for the incinerator furnace to cool the burning gas. The experiment has been operated by means of the newly-built alternating channel type magnetic separating device. The separation ratios of ferromagnetic flocks including fine magnetite powder have been estimated by means of the high gradient magnetic separation method with small iron balls filled in the water channels. As the magnetic force acting on the magnetic particle is given by the product of a magnetization of the material and a gradient of magnetic field, and as the ferromagnetic stainless steel balls yield the steep gradient of magnetic field around them in a strong magnetic field, the system has exhibited a quite excellent performance with respect to the separation ratios. The separation ratios of the flocks which contain the magnetite powder with the values more than 50 ppm have remained over 80% for under the flow rates less than 5 L/min.

  9. Metasystem approach to increase the load factor FMS

    Directory of Open Access Journals (Sweden)

    Pishchukhin Alexandr

    2017-01-01

    Full Text Available The work is devoted to increasing the efficiency of using flexible manufacture systems (FMS by increasing the load factor. Unlike the well-known multi-agent approach to production management, we are investigating the addition of a metasystem level allowing flexible combination of the decentralized control method with centralization. The metasystem approach allows to reduce management to flexible switching of functioning technologies on the basis of the replacement rule, while describing FMS as a metasystem consisting of classification of the system analyst J. Klir from structured data systems. Production events are simulated in virtual space with the help of a multi-agent approach. At the same time, the number of requests from the waiting queue is chosen such that it becomes possible to optimize the loading of the FMS in the simplest case by the full-scan method, if the queue is not available, then the initiative of choice is provided to communications of agents-technologies and agents-equipments. Experimental studies were carried out on the FMS model including six pieces of equipment divided into three groups with a stream of six applications, each of which has a technological route of six operations each‥ The experimental results showed the consistency of the developed approach by increasing the load factor of the FMS.

  10. Strong compound-risk factors: efficient discovery through emerging patterns and contrast sets.

    Science.gov (United States)

    Li, Jinyan; Yang, Qiang

    2007-09-01

    Odds ratio (OR), relative risk (RR) (risk ratio), and absolute risk reduction (ARR) (risk difference) are biostatistics measurements that are widely used for identifying significant risk factors in dichotomous groups of subjects. In the past, they have often been used to assess simple risk factors. In this paper, we introduce the concept of compound-risk factors to broaden the applicability of these statistical tests for assessing factor interplays. We observe that compound-risk factors with a high risk ratio or a big risk difference have an one-to-one correspondence to strong emerging patterns or strong contrast sets-two types of patterns that have been extensively studied in the data mining field. Such a relationship has been unknown to researchers in the past, and efficient algorithms for discovering strong compound-risk factors have been lacking. In this paper, we propose a theoretical framework and a new algorithm that unify the discovery of compound-risk factors that have a strong OR, risk ratio, or a risk difference. Our method guarantees that all patterns meeting a certain test threshold can be efficiently discovered. Our contribution thus represents the first of its kind in linking the risk ratios and ORs to pattern mining algorithms, making it possible to find compound-risk factors in large-scale data sets. In addition, we show that using compound-risk factors can improve classification accuracy in probabilistic learning algorithms on several disease data sets, because these compound-risk factors capture the interdependency between important data attributes.

  11. A study on the load distribution factor in the perforated square plate with elastic support

    International Nuclear Information System (INIS)

    Lee, Y.S.; Yim, J.S.

    1993-01-01

    The load distribution factor in the perforated square plate supporting by angle shape legs under concentrated load acting at arbitrary points through elastic media is calculated. For the calculation the perforated plate was converted into an orthotropic plate using the method suggested by J.B. Mahoney. The deflection for the calculation of the load distribution factor was obtained from the auxiliary plate which was extended both sides of the plate and it was compared with the results from ANSYS calculation. With this deflection, the calculation of the load distribution factor was performed. The result shows that the load distribution factor at the periphery of the plate is larger than that of in the central location. This load distribution factor could be used for re-distribution of the applied load in more accurate analysis of the plate as well as in the analysis of the elastic media as the load factor. (author)

  12. Load and resistance factor design of drilled shafts in shale for lateral loading.

    Science.gov (United States)

    2014-04-01

    A research project involving 32 drilled shaft load tests was undertaken to establish LRFD procedures for : design of drilled shafts subjected to lateral loads. Tests were performed at two Missouri Department of : Transportation (MoDOT) geotechnical r...

  13. Impact Study on Power Factor of Electrical Load in Power Distribution System

    International Nuclear Information System (INIS)

    Syirrazie Che Soh; Harzawardi Hasim; Ahmad Asraf, A.S.

    2014-01-01

    Low Power Factor of electrical loads cause high current is drawn from power supply. The impact of this circumstance is influenced by impedance of electrical load. Therefore, the key consideration of this study is how impedance of electrical loads influence power factor of electrical loads, and then power distribution as the whole. This study is important to evaluate the right action to mitigate low power factor effectively for electrical energy efficiency purpose. (author)

  14. Communication: A Jastrow factor coupled cluster theory for weak and strong electron correlation

    International Nuclear Information System (INIS)

    Neuscamman, Eric

    2013-01-01

    We present a Jastrow-factor-inspired variant of coupled cluster theory that accurately describes both weak and strong electron correlation. Compatibility with quantum Monte Carlo allows for variational energy evaluations and an antisymmetric geminal power reference, two features not present in traditional coupled cluster that facilitate a nearly exact description of the strong electron correlations in minimal-basis N 2 bond breaking. In double-ζ treatments of the HF and H 2 O bond dissociations, where both weak and strong correlations are important, this polynomial cost method proves more accurate than either traditional coupled cluster or complete active space perturbation theory. These preliminary successes suggest a deep connection between the ways in which cluster operators and Jastrow factors encode correlation

  15. Current algebra method for form factors and strong decays with hard pions and kaons

    International Nuclear Information System (INIS)

    Srivastava, P.P.

    1969-01-01

    The F K /F Π ratio between the kaon and pion decay couplings in one lepton pair, sum rules for Weinberg spectral functions, form factor renormalization of the K l3 decay because of the SU(3) symmetry violation and the calculations of strong decays of the K* and K A strange resonances are presented and discussed. (L.C.) [pt

  16. [Distribution of neural memory, loading factor, its regulation and optimization].

    Science.gov (United States)

    Radchenko, A N

    1999-01-01

    Recording and retrieving functions of the neural memory are simulated as a control of local conformational processes in neural synaptic fields. The localization of conformational changes is related to the afferent temporal-spatial pulse pattern flow, the microstructure of connections and a plurality of temporal delays in synaptic fields and afferent pathways. The loci of conformations are described by sets of afferent addresses named address domains. Being superimposed on each other, address domains form a multilayer covering of the address space of the neuron or the ensemble. The superposition factor determines the dissemination of the conformational process, and the fuzzing of memory, and its accuracy and reliability. The engram is formed as detects in the packing of the address space and hence can be retrieved in inverse form. The accuracy of the retrieved information depends on the threshold level of conformational transitions, the distribution of conformational changes in synaptic fields of the neuronal population, and the memory loading factor. The latter is represented in the model by a slow potential. It reflects total conformational changes and displaces the membrane potential to monostable conformational regimes, by governing the exit from the recording regime, the potentiation of the neurone, and the readiness to reproduction. A relative amplitude of the slow potential and the coefficient of postconformational modification of ionic conductivity, which provides maximum reliability, accuracy, and capacity of memory, are calculated.

  17. Test of weak and strong factorization in nucleus-nucleuscollisions atseveral hundred MeV/nucleon

    Energy Technology Data Exchange (ETDEWEB)

    La Tessa, Chiara; Sihver, Lembit; Zeitlin, Cary; Miller, Jack; Guetersloh, Stephen; Heilbronn, Lawrence; Mancusi, Davide; Iwata,Yoshiuki; Murakami, Takeshi

    2006-06-21

    Total and partial charge-changing cross sections have been measured for argon projectiles at 400 MeV/nucleon in carbon, aluminum, copper, tin and lead targets; cross sections for hydrogen were also obtained, using a polyethylene target. The validity of weak and strong factorization properties has been investigated for partial charge-changing cross sections; preliminary cross section values obtained for carbon, neon and silicon at 290 and 400 MeV/nucleon and iron at 400 MeV/nucleon, in carbon, aluminum, copper, tin and lead targets have been also used for testing these properties. Two different analysis methods were applied and both indicated that these properties are valid, without any significant difference between weak and strong factorization. The factorization parameters have then been calculated and analyzed in order to find some systematic behavior useful for modeling purposes.

  18. Moving Aerospace Structural Design Practice to a Load and Resistance Factor Approach

    Science.gov (United States)

    Larsen, Curtis E.; Raju, Ivatury S.

    2016-01-01

    Aerospace structures are traditionally designed using the factor of safety (FOS) approach. The limit load on the structure is determined and the structure is then designed for FOS times the limit load - the ultimate load. Probabilistic approaches utilize distributions for loads and strengths. Failures are predicted to occur in the region of intersection of the two distributions. The load and resistance factor design (LRFD) approach judiciously combines these two approaches by intensive calibration studies on loads and strength to result in structures that are efficient and reliable. This paper discusses these three approaches.

  19. Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression

    Directory of Open Access Journals (Sweden)

    Jenkins Dafyd J

    2008-01-01

    Full Text Available Abstract Background Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance. We explore the role of negative self regulation of transcription in regulating the variability of protein abundance using a variety of stochastic modeling techniques. Results We undertake a novel analysis of a classic model for negative self regulation. We demonstrate that, with standard approximations, protein variance relative to its mean should be independent of repressor strength in a physiological range. Consequently, in that range, the coefficient of variation would increase with repressor strength. However, stochastic computer simulations demonstrate that there is a greater increase in noise associated with strong repressors than predicted by theory. The discrepancies between the mathematical analysis and computer simulations arise because with strong repressors the approximation that leads to Michaelis-Menten-like hyperbolic repression terms ceases to be valid. Because we observe that strong negative feedback increases variability and so is unlikely to be a mechanism for noise control, we suggest instead that negative feedback is evolutionarily favoured because it allows the cell to minimize mRNA usage. To test this, we used in silico evolution to demonstrate that while negative feedback can achieve only a modest improvement in protein noise reduction compared with the unregulated system, it can achieve good improvement in protein response times and very substantial improvement in reducing mRNA levels. Conclusion Strong negative self regulation of transcription may not always be a mechanism for homeostatic control of protein abundance, but instead might be evolutionarily favoured as a mechanism to limit the use of mRNA. The use of hyperbolic terms derived from quasi-steady-state approximation should also be avoided in the analysis of stochastic

  20. 14 CFR 25.527 - Hull and main float load factors.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull and main float load factors. 25.527... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Structure Water Loads § 25.527 Hull and main... 1=empirical hull station weighing factor, in accordance with figure 2 of appendix B. (7) r x=ratio...

  1. Partial safety factors for berthing velocity and loads on marine structures

    NARCIS (Netherlands)

    Roubos, A.A.; Peters, D.J.; Groenewegen, Leon; Steenbergen, R.

    2018-01-01

    Design methods for marine structures have evolved into load and resistance factor design, however existing partial safety factors related to berthing velocity and loads have not been verified and validated by measurement campaigns. In this study, field observations of modern seagoing vessels

  2. Reliability-Based Calibration of Load Duration Factors for Timber Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Svensson, Staffan; Stang, Birgitte Friis Dela

    2005-01-01

    John Dalsgaard Sørensen, Staffan Svensson, Birgitte Dela Stang : Reliability-Based Calibration of Load Duration Factors for Timber Structures     Abstract :   The load bearing capacity of timber structures decrease with time depending on the type of load and timber. Based on representative limit...... states and stochastic models for timber structures, load duration factors are calibrated using probabilistic methods. Load duration e.ects are estimated on basis of simulation of realizations of wind, snow and imposed loads in accordance with the load models in the Danish structural codes. Three damage...... accumulation models are considered, namely Gerhards model, Barrett and Foschi _ s model and Foschi and Yao _ s model. The parameters in these models are .tted by the Maximum Likelihood Method using data relevant for Danish structural timber and the statistical uncertainty is quanti .ed. The reliability...

  3. Characteristics and Motivational Factors of Effective Extension Advisory Leaders: Implications for Building Strong Extension Advisory Councils

    Directory of Open Access Journals (Sweden)

    Joy Kish

    2014-10-01

    Full Text Available The purpose of this study was to determine the characteristics and motivational factors of effective Extension advisory leaders. This Delphi study was conducted with a selected group of County Extension Directors and a group of Extension State Advisory Leaders. The study identified 10 characteristics that distinguish an effective Extension advisory leader. Some of these characteristics are explicit and easy to observe, while others are implicit and difficult to directly observe. Therefore, it is practical to use directly observable characteristics of effective advisory leaders when selecting volunteers. Once potential volunteers are spotted in the community, implicit characteristics of effective advisory leaders should be used to further screen them before they are selected. The study also identified the eight most important factors motivating individuals to volunteer as effective advisory leaders. Understanding these motivational factors is helpful for creating an environment for attracting and retaining effective volunteers. Understanding their motivation for volunteer work and creating an environment for them to meet the motivating factors for volunteering will lead to volunteer satisfaction and retention. The findings of this study can be used to build strong Extension advisory councils.

  4. Calibration of Load Duration Factor kmod

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Stang, Birgitte Friis Dela; Svensson, Staffan

    and the stochastic models are formulated in accordance with the load models in the Danish structural codes, DS 409, and DS 410. three damage accumulation models are considered, namely Gerhards model, Barret & Foschi's model, and Foschi & Yao's model. The parameters in these moels are fitted using data relevant...

  5. Factor Analysis of the Aggregated Electric Vehicle Load Based on Data Mining

    Directory of Open Access Journals (Sweden)

    Yao Wang

    2012-06-01

    Full Text Available Electric vehicles (EVs and the related infrastructure are being developed rapidly. In order to evaluate the impact of factors on the aggregated EV load and to coordinate charging, a model is established to capture the relationship between the charging load and important factors based on data mining. The factors can be categorized as internal and external. The internal factors include the EV battery size, charging rate at different places, penetration of the charging infrastructure, and charging habits. The external factor is the time-of-use pricing (TOU policy. As a massive input data is necessary for data mining, an algorithm is implemented to generate a massive sample as input data which considers real-world travel patterns based on a historical travel dataset. With the input data, linear regression was used to build a linear model whose inputs were the internal factors. The impact of the internal factors on the EV load can be quantified by analyzing the sign, value, and temporal distribution of the model coefficients. The results showed that when no TOU policy is implemented, the rate of charging at home and range anxiety exerts the greatest influence on EV load. For the external factor, a support vector regression technique was used to build a relationship between the TOU policy and EV load. Then, an optimization model based on the relationship was proposed to devise a TOU policy that levels the load. The results suggest that implementing a TOU policy reduces the difference between the peak and valley loads remarkably.

  6. A Simultaneous Measurement of the QCD Colour Factors and the Strong Coupling

    CERN Document Server

    Abbiendi, G.; Akesson, P.F.; Alexander, G.; Allison, John; Anagnostou, G.; Anderson, K.J.; Arcelli, S.; Asai, S.; Axen, D.; Azuelos, G.; Bailey, I.; Ball, H.; Barberio, E.; Barlow, Roger J.; Batley, R.J.; Behnke, T.; Bell, Kenneth Watson; Bella, G.; Bellerive, A.; Benelli, G.; Bethke, S.; Biebel, O.; Bloodworth, I.J.; Boeriu, O.; Bock, P.; Bohme, J.; Bonacorsi, D.; Boutemeur, M.; Braibant, S.; Brigliadori, L.; Brown, Robert M.; Burckhart, H.J.; Cammin, J.; Capiluppi, P.; Carnegie, R.K.; Caron, B.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Clarke, P.E.L.; Clay, E.; Cohen, I.; Couchman, J.; Csilling, A.; Cuffiani, M.; Dado, S.; Dallavalle, G.Marco; Dallison, S.; De Roeck, A.; De Wolf, E.A.; Dervan, P.; Desch, K.; Dienes, B.; Dixit, M.S.; Donkers, M.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Estabrooks, P.G.; Etzion, E.; Fabbri, F.; Fanti, M.; Feld, L.; Ferrari, P.; Fiedler, F.; Fleck, I.; Ford, M.; Frey, A.; Furtjes, A.; Futyan, D.I.; Gagnon, P.; Gary, J.W.; Gaycken, G.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Glenzinski, D.; Goldberg, J.; Grandi, C.; Graham, K.; Gross, E.; Grunhaus, J.; Gruwe, M.; Gunther, P.O.; Gupta, A.; Hajdu, C.; Hanson, G.G.; Harder, K.; Harel, A.; Harin-Dirac, M.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Hensel, C.; Herten, G.; Heuer, R.D.; Hill, J.C.; Hoffman, Kara Dion; Homer, R.J.; Honma, A.K.; Horvath, D.; Hossain, K.R.; Howard, R.; Huntemeyer, P.; Igo-Kemenes, P.; Ishii, K.; Jawahery, A.; Jeremie, H.; Jones, C.R.; Jovanovic, P.; Junk, T.R.; Kanaya, N.; Kanzaki, J.; Karapetian, G.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kim, D.H.; Klein, K.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Kokott, T.P.; Komamiya, S.; Kowalewski, Robert V.; Kamer, T.; Kress, T.; Krieger, P.; von Krogh, J.; Krop, D.; Kuhl, T.; Kupper, M.; Kyberd, P.; Lafferty, G.D.; Landsman, H.; Lanske, D.; Lawson, I.; Layter, J.G.; Leins, A.; Lellouch, D.; Letts, J.; Levinson, L.; Liebisch, R.; Lillich, J.; Littlewood, C.; Lloyd, A.W.; Lloyd, S.L.; Loebinger, F.K.; Long, G.D.; Losty, M.J.; Lu, J.; Ludwig, J.; Macchiolo, A.; Macpherson, A.; Mader, W.; Marcellini, S.; Marchant, T.E.; Martin, A.J.; Martin, J.P.; Martinez, G.; Mashimo, T.; Mattig, Peter; McDonald, W.John; McKenna, J.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Mendez-Lorenzo, P.; Menges, W.; Merritt, F.S.; Mes, H.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D.J.; Mohr, W.; Montanari, A.; Mori, T.; Nagai, K.; Nakamura, I.; Neal, H.A.; Nisius, R.; O'Neale, S.W.; Oakham, F.G.; Odorici, F.; Oh, A.; Okpara, A.; Oreglia, M.J.; Orito, S.; Pahl, C.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poli, B.; Polok, J.; Pooth, O.; Quadt, A.; Rabbertz, K.; Rembser, C.; Renkel, P.; Rick, H.; Rodning, N.; Roney, J.M.; Rosati, S.; Roscoe, K.; Rossi, A.M.; Rozen, Y.; Runge, K.; Runolfsson, O.; Rust, D.R.; Sachs, K.; Saeki, T.; Sahr, O.; Sarkisian, E.K.G.; Sbarra, C.; Schaile, A.D.; Schaile, O.; Scharff-Hansen, P.; Schroder, Matthias; Schumacher, M.; Schwick, C.; Scott, W.G.; Seuster, R.; Shears, T.G.; Shen, B.C.; Shepherd-Themistocleous, C.H.; Sherwood, P.; Siroli, G.P.; Skuja, A.; Smith, A.M.; Snow, G.A.; Sobie, R.; Soldner-Rembold, S.; Spagnolo, S.; Spano, F.; Sproston, M.; Stahl, A.; Stephens, K.; Strom, David M.; Strohmer, R.; Stumpf, L.; Surrow, B.; Talbot, S.D.; Tarem, S.; Tasevsky, M.; Taylor, R.J.; Teuscher, R.; Thomas, J.; Thomson, M.A.; Torrence, E.; Towers, S.; Toya, D.; Trefzger, T.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turner-Watson, M.F.; Ueda, I.; Vachon, B.; Vollmer, C.F.; Vannerem, P.; Verzocchi, M.; Voss, H.; Vossebeld, J.; Waller, D.; Ward, C.P.; Ward, D.R.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wengler, T.; Wermes, N.; Wetterling, D.; White, J.S.; Wilson, G.W.; Wilson, J.A.; Wyatt, T.R.; Yamashita, S.; Zacek, V.; Zer-Zion, D.

    2001-01-01

    Using data from e+e- annihilation into hadrons, taken with the OPAL detector at LEP at the Z pole between 1991 and 1995, we performed a simultaneous measurement of the colour factors of the underlying gauge group of the strong interaction, CF and CA, and the strong coupling, alpha(s). The measurement was carried out by fitting next-to-leading order perturbative predictions to measured angular correlations of 4-jet events together with multi-jet related variables. Our results, CA = 3.02 +/- 0.25 (stat.) +/- 0.49 (syst.) CF = 1.34 +/- 0.13 (stat.) +/- 0.22 (syst.), alpha(s)(M_Z) = 0.120 +/- 0.011 (stat.) +/- 0.020 (syst.), provide a test of perturbative QCD in which the only assumptions are non-abelian gauge symmetry and standard hadronization models. The measurements are in agreement with SU(3) expectations for CF and CA and the world average of alpha(s)(M_Z).

  7. Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett’s Esophagus

    Science.gov (United States)

    Bazin, Camille; Benezech, Alban; Alessandrini, Marine; Grimaud, Jean-Charles; Vitton, Veronique

    2018-01-01

    Background/Aims Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett’s esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. Methods A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry. The clinical data collected was known or potential risk factors for BE: male gender, smoking and alcohol consumption, age, body mass index, presence of hiatal hernia, frequency, and age of GERD. EMD were classified according to the Chicago classification into: ineffective motor syndrome, fragmented peristalsis and absence of peristalsis, lower esophageal sphincter hypotonia. Results Two hundred and one patients (101 in the GERD + BE group and 100 in the GERD without BE) were included. In univariate analysis, male gender, alcohol consumption, presence of hiatal hernia, and EMD appeared to be associated with the presence of BE. In a multivariate analysis, 3 independent factors were identified: the presence of EMD (odds ratio [OR], 3.99; 95% confidence interval [CI], 1.71–9.28; P = 0.001), the presence of hiatal hernia (OR, 5.60; 95% CI, 2.45–12.76; P motor syndrome and lower esophageal sphincter hypotonia) is a strong independent associated factor of BE. Searching systematically for an EMD in patients suffering from GERD could be a new strategy to organize the endoscopic follow-up. PMID:29605977

  8. Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett's Esophagus.

    Science.gov (United States)

    Bazin, Camille; Benezech, Alban; Alessandrini, Marine; Grimaud, Jean-Charles; Vitton, Veronique

    2018-04-30

    Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett's esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry. The clinical data collected was known or potential risk factors for BE: male gender, smoking and alcohol consumption, age, body mass index, presence of hiatal hernia, frequency, and age of GERD. EMD were classified according to the Chicago classification into: ineffective motor syndrome, fragmented peristalsis and absence of peristalsis, lower esophageal sphincter hypotonia. Two hundred and one patients (101 in the GERD + BE group and 100 in the GERD without BE) were included. In univariate analysis, male gender, alcohol consumption, presence of hiatal hernia, and EMD appeared to be associated with the presence of BE. In a multivariate analysis, 3 independent factors were identified: the presence of EMD (odds ratio [OR], 3.99; 95% confidence interval [CI], 1.71-9.28; P = 0.001), the presence of hiatal hernia (OR, 5.60; 95% CI, 2.45-12.76; P < 0.001), Helicobacter pylori infection (OR, 0.08; 95% CI, 0.01-0.84; P = 0.035). The presence of EMD (particularly ineffective motor syndrome and lower esophageal sphincter hypotonia) is a strong independent associated factor of BE. Searching systematically for an EMD in patients suffering from GERD could be a new strategy to organize the endoscopic follow-up.

  9. Strong regional links between socio-economic background factors and disability and mortality in Oslo, Norway

    International Nuclear Information System (INIS)

    Rognerud, Marit Aase; Krueger, Oystein; Gjertsen, Finn; Thelle, Dag Steinar

    1998-01-01

    Study objective: To study geographical differences in mortality and disability and sosio-economic status in Oslo, Norway. Setting: A total of 25 local authority districts within the city of Oslo. Design: Analysis of age adjusted mortality rates aged 0-74 in the period 1991-1994, and cross sectional data on disability pensioners aged 50-66 and socio-economic indicators (low education, single parenthood, unemployment, high income) in 1994. Main outcome measures: The levels of correlation between the health outcomes (mortality and disability) and sosio-economic exposure variables. Main results: The geographical patterns of mortality and disability display substantial similarities and show strong linear correlation with area measures of socio-economic deprivation. The ratios between the highest and lowest area mortality rates were 3.3 for men and 2.1 for women, while the high-low ratios of disability were 7.0 for men and 3.8 for women. For women deprivation measures are better correlated with disability than mortality. While disability and mortality display similar correlations with deprivation measures for men. Conclusions: The social gradients in health are substantial in Oslo. Further ecological analysis of cause specific morbidity and mortality and the distribution of risk factors ought to be done to identify problem areas suitable for interventions. However, to understand the mechanisms and the relative importance of each etiological factor, studies based on individual data have to be performed

  10. Divergent responses of tropical cyclone genesis factors to strong volcanic eruptions at different latitudes

    Science.gov (United States)

    Yan, Qing; Zhang, Zhongshi; Wang, Huijun

    2018-03-01

    To understand the behaviors of tropical cyclones (TCs), it is very important to explore how TCs respond to anthropogenic greenhouse gases and natural forcings. Volcanic eruptions are a major natural forcing mechanism because they inject sulphate aerosols into the stratosphere, which modulate the global climate by absorbing and scattering solar radiation. The number of Atlantic hurricanes is thought to be reduced following strong tropical eruptions, but whether the response of TCs varies with the locations of the volcanoes and the different ocean basins remains unknown. Here, we use the Community Earth System Model-Last Millennium Ensemble to investigate the response of the large-scale environmental factors that spawn TCs to strong volcanic eruptions at different latitudes. A composite analysis indicates that tropical and northern hemisphere volcanic eruptions lead to significantly unfavorable conditions for TC genesis over the whole Pacific basin and the North Atlantic during the 3 years post-eruption, relative to the preceding 3 years. Southern hemisphere volcanic eruptions result in obviously unfavorable conditions for TC formation over the southwestern Pacific, but more favorable conditions over the North Atlantic. The mean response over the Indian Ocean is generally muted and insignificant. It should be noted that volcanic eruptions impact on environmental conditions through both the direct effect (i.e. on radiative forcing) and the indirect effect (i.e. on El Niño-Southern Oscillation), which is not differentiated in this study. In addition, the spread of the TC genesis response is considerably large for each category of eruptions over each ocean basin, which is also seen in the observational/proxy-based records. This large spread is attributed to the differences in stratospheric aerosol distributions, initial states and eruption intensities, and makes the short-term forecast of TC activity following the next large eruption challenging.

  11. Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes

    NARCIS (Netherlands)

    Juffer, P.; Jaspers, R.T.; Lips, P.; Bakker, A.D.; Klein-Nulend, J.

    2012-01-01

    Lack of physical activity results in muscle atrophy and bone loss, which can be counteracted by mechanical loading. Similar molecular signaling pathways are involved in the adaptation of muscle and bone mass to mechanical loading. Whether anabolic and metabolic factors regulating muscle mass, i.e.,

  12. The effect of some ecological factors on the intestinal parasite loads ...

    Indian Academy of Sciences (India)

    Some ecological factors that might potentially influence intestinal parasite loads in the Asian elephant (Elephas maximus Linn.) were investigated in the Nilgiris, southern India. Fresh dung samples from identified animals were analysed, and the number of eggs/g of dung used as an index of parasite load. Comparisons ...

  13. Strong association of epidermal growth factor receptor status with breast cancer FDG uptake

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Joohee; Moon, Seung Hwan; Hyun, Seung Hyup; Cho, Young Seok; Choi, Joon Young; Kim, Byung-Tae; Lee, Kyung-Han [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Lee, Eun Jeong [Seoul Medical Center, Department of Nuclear Medicine, Seoul (Korea, Republic of); Kim, Seokhwi [Sungkyunkwan University School of Medicine, Department of Pathology, Samsung Medical Center, Seoul (Korea, Republic of)

    2017-08-15

    Imaging tumor FDG uptake could complement breast cancer biomarkers of risk and treatment response. Although breast cancer FDG uptake is reputedly influenced by major biomarker states, the role of epidermal growth factor receptor (EGFR) expression remains largely unexplored. This is a retrospective study that included 499 patients with primary breast cancer at initial presentation. Tumor FDG uptake was measured on pretreatment PET/CT as maximum standardized uptake value (SUVmax), and biomarkers were assessed by immunohistochemistry of tumor tissue. Regression analysis was performed for predictors of high tumor FDG uptake (SUVmax ≥ 8.6). SUVmax was higher in ER- (36.5%; 11.2 ± 6.0 vs. 8.3 ± 5.3), PR- (42.3%; 10.9 ± 6.0 vs. 8.2 ± 5.2), and triple-negative tumors (19.8%; 12.0 ± 6.9 vs. 8.7 ± 5.2; all p < 0.0001). EGFR expression (28.5%) was more frequent in ER-, PR-, triple-negative, cytokeratin 5/6 (CK5/6) + and mutant P53 (mP53) + tumors (all p < 0.0001). EGFR+ was associated with higher SUVmax among all tumors (11.9 ± 6.0 vs. 8.3 ± 5.3), ER- tumors (p < 0.0001), PR- and + tumors (p < 0.0001 and 0.027), hormone receptor- and + tumors (p < 0.0001 and 0.004), human epidermal growth factor receptor 2 (HER2)- and + tumors (p < 0.0001 and 0.006), non-triple negative tumors (p < 0.0001), CK5/6- and + tumors (p = 0.021 and <0.0001), and mP53- and + tumors (p < 0.0001 and 0.008). Tumors had high FDG uptake in 73.2% of EGFR+ and 40.6% of EGFR- tumors. On regression analysis, significant multivariate predictors of high tumor FDG uptake were large size, EGFR+ and CK5/6+ for the entire subjects, and EGFR+ and CK5/6+ for ER- and hormone receptor negative subgroups. High FDG uptake was able to sub-stratify EGFR+ tumors that were more likely to be ER- and CK5/6+, and EGFR- tumors more likely to be mP53 +. Primary breast tumor FDG uptake is strongly influenced by EGFR status beyond that by other major biomarkers including hormone receptor and HER2 status, and EGFR

  14. Anterior cruciate ligament injuries in soccer: Loading mechanisms, risk factors, and prevention programs

    Directory of Open Access Journals (Sweden)

    Boyi Dai

    2014-12-01

    Full Text Available Anterior cruciate ligament (ACL injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.

  15. Load and resistance factor rating (LRFR) in New York State : volume II.

    Science.gov (United States)

    2011-09-01

    This report develops a Load and Resistance Factor Rating (NYS-LRFR) methodology : for New York bridges. The methodology is applicable for the rating of existing : bridges, the posting of under-strength bridges, and checking Permit trucks. The : propo...

  16. Load and resistance factor rating (LRFR) in New York State : volume I.

    Science.gov (United States)

    2011-09-01

    This report develops a Load and Resistance Factor Rating (NYS-LRFR) methodology : for New York bridges. The methodology is applicable for the rating of existing : bridges, the posting of under-strength bridges, and checking Permit trucks. The : propo...

  17. Experimental and Numerical Evaluation of the Mechanical Behavior of Strongly Anisotropic Light-Weight Metallic Fiber Structures under Static and Dynamic Compressive Loading

    Directory of Open Access Journals (Sweden)

    Olaf Andersen

    2016-05-01

    Full Text Available Rigid metallic fiber structures made from a variety of different metals and alloys have been investigated mainly with regard to their functional properties such as heat transfer, pressure drop, or filtration characteristics. With the recent advent of aluminum and magnesium-based fiber structures, the application of such structures in light-weight crash absorbers has become conceivable. The present paper therefore elucidates the mechanical behavior of rigid sintered fiber structures under quasi-static and dynamic loading. Special attention is paid to the strongly anisotropic properties observed for different directions of loading in relation to the main fiber orientation. Basically, the structures show an orthotropic behavior; however, a finite thickness of the fiber slabs results in moderate deviations from a purely orthotropic behavior. The morphology of the tested specimens is examined by computed tomography, and experimental results for different directions of loading as well as different relative densities are presented. Numerical calculations were carried out using real structural data derived from the computed tomography data. Depending on the direction of loading, the fiber structures show a distinctively different deformation behavior both experimentally and numerically. Based on these results, the prevalent modes of deformation are discussed and a first comparison with an established polymer foam and an assessment of the applicability of aluminum fiber structures in crash protection devices is attempted.

  18. Power factor improvement in three-phase networks with unbalanced inductive loads using the Roederstein ESTAmat RPR power factor controller

    Science.gov (United States)

    Diniş, C. M.; Cunţan, C. D.; Rob, R. O. S.; Popa, G. N.

    2018-01-01

    The paper presents the analysis of a power factor with capacitors banks, without series coils, used for improving power factor for a three-phase and single-phase inductive loads. In the experimental measurements, to improve the power factor, the Roederstein ESTAmat RPR power factor controller can command up to twelve capacitors banks, while experimenting using only six capacitors banks. Six delta capacitors banks with approximately equal reactive powers were used for experimentation. The experimental measurements were carried out with a three-phase power quality analyser which worked in three cases: a case without a controller with all capacitors banks permanently parallel connected with network, and two other cases with power factor controller (one with setting power factor at 0.92 and the other one at 1). When performing experiments with the power factor controller, a current transformer was used to measure the current on one phase (at a more charged or less loaded phase).

  19. Reliability-based load and resistance factor design for piping: an exploratory case study

    International Nuclear Information System (INIS)

    Gupta, Abhinav; Choi, Byounghoan

    2003-01-01

    This paper presents an exploratory case study on the application of Load and Resistance Factor Design (LRFD) approach to the Section III of ASME Boiler and Pressure Vessel code for piping design. The failure criterion for defining the performance function is considered as plastic instability. Presently used design equation is calibrated by evaluating the minimum reliability levels associated with it. If the target reliability in the LRFD approach is same as that evaluated for the presently used design equation, it is shown that the total safety factors for the two design equations are identical. It is observed that the load and resistance factors are not dependent upon the diameter to thickness ratio. A sensitivity analysis is also conducted to study the variations in the load and resistance factors due to changes in (a) coefficients of variation for pressure, moment, and ultimate stress, (b) ratio of mean design pressure to mean design moment, (c) distribution types used for characterizing the random variables, and (d) statistical correlation between random variables. It is observed that characterization of random variables by log-normal distribution is reasonable. Consideration of statistical correlation between the ultimate stress and section modulus gives higher values of the load factor for pressure but lower value for the moment than the corresponding values obtained by considering the variables to be uncorrelated. Since the effect of statistical correlation on the load and resistance factors is relatively insignificant for target reliability values of practical interest, the effect of correlated variables may be neglected

  20. Environmental load factors and system strength evaluation of offshore jacket platforms

    CERN Document Server

    Nizamani, Zafarullah

    2015-01-01

    This book presents a study for the determination of environmental load factors for Jacket Platforms in Malaysia and a methodology to determine the life extension of aging platforms. The simplified methods described here could be used for determining not only structural reliability but also safety factors. Its content is particularly interesting to design and maintenance engineers who are working in offshore or onshore industry.

  1. Importance of nuclear station load factor in applied ro energy policies

    International Nuclear Information System (INIS)

    Gomes, Daniel de Souza

    2015-01-01

    Load factor is the ration between the energy produced by a station and the energy it would have produced running at maximum power. The factor intends for all types of commercial reactors. Nuclear plants continuously provide over 11% of the world's electricity. The reactors for which data were available generated 618.7 TWh of electricity in 2014. Typical load factor was around 75% in worldwide during the first quarter of 2015. In this manner, it obtained from an average, three-monthly or yearly. The regular load factor of the reactors in operation was around 56% in 1970. While, in 1980's decade, we have an increase to 63%, the same situation occurred in next the decade and suffering increasing to 73%. Currently, the load factor reaches 78%. Accidents are seasonal factors, with the occurrence of reduction of power generation plants. In 2015 in January, there are over 437 operable commercial reactors in 31 countries, with over 377,728 MWe of full capacity. In Brazil, total capacity is 1901 MWe, with around 2.8% of electricity energy consumed. The primary objective of this study was to find a forecast model that express the evolution of the load factor in the next years. In recent years occur an extensive development of pressurized water reactors in Asia. The periodicity of seasonal effects on the performance of nuclear power plants due to aging. However, the impact of plant age depended on new technologies that allow the growth of the performance. The accident of Fukushima was an inflection point for energy policies. The event produced a trend that reduced the load in the world. (author)

  2. What is the relationship between mental workload factors and cognitive load types?

    Science.gov (United States)

    Galy, Edith; Cariou, Magali; Mélan, Claudine

    2012-03-01

    The present study tested the hypothesis of an additive interaction between intrinsic, extraneous and germane cognitive load, by manipulating factors of mental workload assumed to have a specific effect on either type of cognitive load. The study of cognitive load factors and their interaction is essential if we are to improve workers' wellbeing and safety at work. High cognitive load requires the individual to allocate extra resources to entering information. It is thought that this demand for extra resources may reduce processing efficiency and performance. The present study tested the effects of three factors thought to act on either cognitive load type, i.e. task difficulty, time pressure and alertness in a working memory task. Results revealed additive effects of task difficulty and time pressure, and a modulation by alertness on behavioral, subjective and psychophysiological workload measures. Mental overload can be the result of a combination of task-related components, but its occurrence may also depend on subject-related characteristics, including alertness. Solutions designed to reduce incidents and accidents at work should consider work organization in addition to task constraints in so far that both these factors may interfere with mental workload. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. Means of achieving high load factors at Olkiluoto 1 and 2

    International Nuclear Information System (INIS)

    Patrakka, E.

    2001-01-01

    Teollisuuden Voima Oy operates two BWR units Olkiluoto 1 and 2 that have achieved load factors typically higher than 90%. The operating experiences gained in the 1990s is summarised and the factors contributing to the high capacity factors are addressed. These include the general objectives for operation and maintenance, plant modernisation programme, maintenance principles, and outage policy and experiences. Finally, the international evaluations performed at Olkiluoto are mentioned. (author)

  4. The effect of load factor on fission product decay heat from discharged reactor fuel

    International Nuclear Information System (INIS)

    Davies, B.S.J.

    1978-07-01

    A sum-of-exponentials expression representing the decay heat power following a burst thermal irradiation of 235 U has been used to investigate the effect of load factor during irradiation on subsequent decay heat production. A sequence of random numbers was used to indicate reactor 'on' and 'off' periods for irradiations which continued for a total of 1500 days at power and were followed by 100 days cooling. It was found that for these conditions decay heat is almost proportional to load factor. Estimates of decay heat uncertainty arising from the random irradiation pattern are also given. (author)

  5. Nerve growth factor loaded heparin/chitosan scaffolds for accelerating peripheral nerve regeneration.

    Science.gov (United States)

    Li, Guicai; Xiao, Qinzhi; Zhang, Luzhong; Zhao, Yahong; Yang, Yumin

    2017-09-01

    Artificial chitosan scaffolds have been widely investigated for peripheral nerve regeneration. However, the effect was not as good as that of autologous grafts and therefore could not meet the clinical requirement. In the present study, the nerve growth factor (NGF) loaded heparin/chitosan scaffolds were fabricated via electrostatic interaction for further improving nerve regeneration. The physicochemical properties including morphology, wettability and composition were measured. The heparin immobilization, NGF loading and release were quantitatively and qualitatively characterized, respectively. The effect of NGF loaded heparin/chitosan scaffolds on nerve regeneration was evaluated by Schwann cells culture for different periods. The results showed that the heparin immobilization and NGF loading did not cause the change of bulk properties of chitosan scaffolds except for morphology and wettability. The pre-immobilization of heparin in chitosan scaffolds could enhance the stability of subsequently loaded NGF. The NGF loaded heparin/chitosan scaffolds could obviously improve the attachment and proliferation of Schwann cells in vitro. More importantly, the NGF loaded heparin/chitosan scaffolds could effectively promote the morphology development of Schwann cells. The study may provide a useful experimental basis to design and develop artificial implants for peripheral nerve regeneration and other tissue regeneration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Serviceability design load factors and reliability assessments for reinforced concrete containment structures

    International Nuclear Information System (INIS)

    Han Bong Koo

    1998-01-01

    A reinforced concrete nuclear power plant containment structure is subjected to various random static and stochastic loads during its lifetime. Since these loads involve inherent randomness and other uncertainties, an appropriate probabilistic model for each load must be established in order to perform reliability analysis. The current ASME code for reinforced concrete containment structures are not based on probability concepts. The stochastic nature of natural hazard or accidental loads and the variations of material properties require a probabilistic approach for a rational assessment of structural safety and performance. The paper develops probability-based load factors for the limit state design of reinforced concrete containment structures. The purpose of constructing reinforced concrete containment structure is to protect against radioactive release, and so the use of a serviceability limit state against crack failure that can cause the emission of radioactive materials is suggested as a critical limit state for reinforced concrete containment structures. Load factors for the design of reinforced concrete containment structures are proposed and carried out the reliability assessments. (orig.)

  7. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  8. technical note: technical note: on the correctness of load loss factor ...

    African Journals Online (AJOL)

    eobe

    Load Loss Factor (LLF) is a function of the estimate of the losses between the grid supply point and the consumers. estimate ... i.e. the ratio of average demand to peak demand, and using this ratio to determine an approximation to the. LLF via ...

  9. Main factors affecting strong ground motion calculations: Critical review and assessment

    International Nuclear Information System (INIS)

    Mohammadioun, B.; Pecker, A.

    1990-01-01

    In the interests of guarding lives and property against the effects of earthquakes, building codes are frequently enforced when erecting conventional structures, usually calling for simple, static calculations. Where more vulnerable facilities are involved, the failure of which, or of parts of which, could subject the environment to harmful substances, more sophisticated methods are used to compute or verify their design, often accompanied by safety margins intended to compensate for uncertainties encountered at various stages of the analysis that begins with input seismic data and culminates with an effective anti-seismic design. The forthcoming discussion will deal with what is known of the characteristics of strong ground motion, highly variable according to context, without entering into the problems raised by seismotectonic studies, which actually constitute the first aspect that must be addressed when performing such an analysis. Our conclusion will be devoted to cogent R and D work in this area

  10. Main factors affecting strong ground motion calculations: Critical review and assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadioun, B [DAS/SASC (France); Pecker, A [Societe Geodynamique et Structure (France)

    1990-07-01

    In the interests of guarding lives and property against the effects of earthquakes, building codes are frequently enforced when erecting conventional structures, usually calling for simple, static calculations. Where more vulnerable facilities are involved, the failure of which, or of parts of which, could subject the environment to harmful substances, more sophisticated methods are used to compute or verify their design, often accompanied by safety margins intended to compensate for uncertainties encountered at various stages of the analysis that begins with input seismic data and culminates with an effective anti-seismic design. The forthcoming discussion will deal with what is known of the characteristics of strong ground motion, highly variable according to context, without entering into the problems raised by seismotectonic studies, which actually constitute the first aspect that must be addressed when performing such an analysis. Our conclusion will be devoted to cogent R and D work in this area.

  11. Psychosocial factors and mental work load: a reality perceived by nurses in intensive care units

    Directory of Open Access Journals (Sweden)

    Paula Ceballos-Vásquez

    2015-04-01

    Full Text Available OBJECTIVE: To analyse the perception of psychosocial factors and mental workload of nurses who work in intensive care units. It is hypothesised that nurses in these units could perceive psychosocial risks, manifesting in a high mental work load. The psychosocial dimension related to the position's cognitive demands is hypothesised to mostly explain mental work load. METHOD: Quantitative study, with a descriptive, cross-sectional, and comparative design. A total of 91% of the intensive care unit populations of three Chilean hospitals was surveyed, corresponding to 111 nurses. The instruments utilised included (A a biosociodemographic history questionnaire; (b the SUSESO-ISTAS 21 questionnaire; and (c the Mental Work Load Subjective Scale (ESCAM, in Spanish. RESULTS: In total, 64% and 57% of participants perceived high levels of exposure to the psychosocial risks Psychosocial demands and Double shift, respectively. In addition, a medium-high level of overall mental load was observed. Positive and significant correlations between some of the SUSESO-ISTAS 21 and ESCAM dimensions were obtained. Using a regression analysis, it was determined that three dimensions of the psychosocial risk questionnaire helped to explain 38% of the overall mental load. CONCLUSION: Intensive care unit nurses felt that inadequate psychosocial factors and mental work overload existed in several of the tested dimensions.

  12. System incremental cost calculations using the participation factor load-flow formulation

    International Nuclear Information System (INIS)

    Meisel, J.

    1993-01-01

    The load-flow problem is reformulated such that the use of a slack-bus generator is included only as a special case. This reformulation, known as the participation factor load-flow, includes a total mismatch variable and a defined participation vector, which, in general, distributes this mismatch to all system buses. The slack-bus constraint can still be obtained by defining a particular participation vector. In using the participation factor load-flow in the transpose Jacobian approach to the economic optimal dispatch problem, the paper shows that the value of the system-λ can be controlled such that this value represents the minimal incremental change in generation costs per unit change in system total demand with this demand distributed according to the specified participation vector. Methods using the conventional B-coefficient loss formulas or slack-bus load-flows give system-λ values whereby the unit change in demand must be placed on a fictitious single load-bus or on the slack-bus, respectively. Having a system-λ value which more accurately represents a proposed energy interchange between interconnected systems is very important in developing valid costs for each system. An extensive 28-bus, 8-generator system is included to illustrate these results

  13. Elastic removal self-shielding factors for light and medium nuclides with strong-resonance scattering

    International Nuclear Information System (INIS)

    Nakagawa, Masayuki; Ishiguro, Yukio; Tokuno, Yukio.

    1978-01-01

    The self-shielding factors for elastic removal cross sections of light and medium weight nuclides were calculated for the parameter, σ 0 within the conventional concept of the group constant sets. The numerical study were performed for obtaining a simple and accurate method. The present results were compared with the exact values and the conventional ones, and shown to be remarkably improved. It became apparent that the anisotropy of the elastic scattering did not affect to the self-shielding factors though it did to the infinite dilution cross sections. With use of the present revised set, the neutron flux were calculated in an iron medium and in a prototype FBR and compared with those by the fine spectrum calculations and the conventional set. The present set showed the considerable improvement in the vicinity of the large resonance regions of sodium, iron and oxygen. (auth.)

  14. Analysis of bus passenger comfort perception based on passenger load factor and in-vehicle time.

    Science.gov (United States)

    Shen, Xianghao; Feng, Shumin; Li, Zhenning; Hu, Baoyu

    2016-01-01

    Although bus comfort is a crucial indicator of service quality, existing studies tend to focus on passenger load and ignore in-vehicle time, which can also affect passengers' comfort perception. Therefore, by conducting surveys, this study examines passengers' comfort perception while accounting for both factors. Then, using the survey data, it performs a two-way analysis of variance and shows that both in-vehicle time and passenger load significantly affect passenger comfort. Then, a bus comfort model is proposed to evaluate comfort level, followed by a sensitivity analysis. The method introduced in this study has theoretical implications for bus operators attempting to improve bus service quality.

  15. Influence of overelastic loading on the stress intensity factor under thermal fatigue conditions

    International Nuclear Information System (INIS)

    Stamm, H.; Munz, D.

    1983-10-01

    Thermal shock loading often creates high thermal stresses which may exceed yield strength of the material in a surface layer. In this report the application of the linear elastic ΔK-concept in the case of cyclic thermal loading within the shakedown region is discussed. To this K-factors for an edge crack in a linear elastic - perfectly plastic plate are calculated using the weight function method and are compared with results obtained with the Finite Element Method. It is shown, that rearrangement stresses during plastic flow in the first cycle must be taken into account developing conservative approximation procedures. (orig.) [de

  16. Acute post cessation smoking. A strong predictive factor for metabolic syndrome among adult Saudis

    International Nuclear Information System (INIS)

    AlDaghri, Nasser M.

    2009-01-01

    To determine the influence of tobacco exposure in the development of metabolic syndrome (MS) in the adult Saudi population. Six hundred and sixty-four adults (305 males and 359 females) aged 25-70 years were included in this cross-sectional study conducted at the King Abdul Aziz University Hospital, between June 2006 and May 2007. We classified the participants into non-smokers, smokers, and ex-smokers (defined as complete cessation for 1-2 years). All subjects were screened for the presence of MS using the modified American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and World Health Organization (WHO) definitions. Metabolic syndrome was highest among ex-smokers regardless of definition used. Relative risk for ex-smokers (95% CI: 2.23, 1.06-4.73) was more than twice in harboring MS as compared to non-smokers (95% CI: 2.78, 1.57-4.92) (p=0.009). Acute post-cessation smoking is a strong predictor for MS among male and female Arabs. Smoking cessation programs should include a disciplined lifestyle and dietary intervention to counteract the MS-augmenting side-effect of smoking cessation. (author)

  17. A New V2G Control Strategy for Load Factor Improvement Using Smoothing Technique

    Directory of Open Access Journals (Sweden)

    CHANHOM, P.

    2017-08-01

    Full Text Available This paper proposes a new vehicle-to-grid (V2G control strategy for improving the load factor in the power network. To operate the proposed strategy, the available storage capacity of the PEVs’ batteries is considered as a battery energy storage system (BESS for charging and discharging an amount of power corresponding to the V2G power command. Due to the remarkable advantages of the technique so-called simple moving average, it is selected for applying in the proposed V2G control strategy. In this research, for investigating the load factor improvement, the essential data including the daily-load profiles with 7-day and 14-day periods are used for the 3 studied cases. These 3 studied cases present the power network with variation of the PEVs locations for describing the PEVs usage and charging or discharging behavior. The performance of the proposed strategy is simulated and verified by the MATPOWER software. The simulation results show that the load factors of the 3 studied cases are improved. Moreover, the encouragement of energy arbitrage for the PEVs owners is also discussed in this paper.

  18. Elk3 from hamster-a ternary complex factor with strong transcriptional repressor activity

    DEFF Research Database (Denmark)

    Hjortoe, G.M.; Weilguny, D.; Willumsen, Berthe Marie

    2005-01-01

    the transcription of genes that are activated during entry into G1. We have isolated the Cricetulus griseus Elk3 gene from the Chinese hamster ovary (CHO) cell line and investigated the transcriptional potential of this factor. Transient transfections revealed that, in addition to its regulation of the c......-fos promoter, Elk3 from CHO cells seems to inhibit other promoters controlling expression of proteins involved in G1/S phase progression; Cyclin D1 and DHFR. As has been described for the Elk3 homologs Net (Mouse) and Sap-2 (Human), the results of the present study further indicate that hamster Elk3...

  19. Development of reliability-based load and resistance factor design methods for piping

    International Nuclear Information System (INIS)

    Ayyub, Bilal M.; Hill, Ralph S. III; Balkey, Kenneth R.

    2003-01-01

    Current American Society of Mechanical Engineers (ASME) nuclear codes and standards rely primarily on deterministic and mechanistic approaches to design. The American Institute of Steel Construction and the American Concrete Institute, among other organizations, have incorporated probabilistic methodologies into their design codes. ASME nuclear codes and standards could benefit from developing a probabilistic, reliability-based, design methodology. This paper provides a plan to develop the technical basis for reliability-based, load and resistance factor design of ASME Section III, Class 2/3 piping for primary loading, i.e., pressure, deadweight and seismic. The plan provides a proof of concept in that LRFD can be used in the design of piping, and could achieve consistent reliability levels. Also, the results from future projects in this area could form the basis for code cases, and additional research for piping secondary loads. (author)

  20. Factors controlling strength of structures, and anticipated overstrength for seismic load conditions

    International Nuclear Information System (INIS)

    Singh, A.K.

    1985-01-01

    This paper discusses how the safe shutdown earthquake level, the ratio of operating basis earthquake to safe shutdown earthquake level, the shape of the earthquake spectra and the modeling of the structure affect the seismic overstrength of structures. The relationship between actual mean strength and the minimum specified strength of concrete and structural steel is also presented. The paper identifies which concrete and steel structures are generally sized for earthquake loads and which are generally sized for other factors, e.g., tornado missiles, loss of coolant accident pressure loads, equipment laydown loads and radiation shielding. The results of a study evaluating the mean ultimate capacity of a pressurized water reactor containment are presented to show that in terms of a ground motion, the seismic capacity may be four to five times the design safe shutdown earthquake level

  1. On Strong Positive Frequency Dependencies of Quality Factors in Local-Earthquake Seismic Studies

    Science.gov (United States)

    Morozov, Igor B.; Jhajhria, Atul; Deng, Wubing

    2018-03-01

    Many observations of seismic waves from local earthquakes are interpreted in terms of the frequency-dependent quality factor Q( f ) = Q0 f^{η } , where η is often close to or exceeds one. However, such steep positive frequency dependencies of Q require careful analysis with regard to their physical consistency. In particular, the case of η = 1 corresponds to frequency-independent (elastic) amplitude decays with time and consequently requires no Q-type attenuation mechanisms. For η > 1, several problems with physical meanings of such Q-factors occur. First, contrary to the key premise of seismic attenuation, high-frequency parts of the wavefield are enhanced with increasing propagation times relative to the low-frequency ones. Second, such attenuation cannot be implemented by mechanical models of wave-propagating media. Third, with η > 1, the velocity dispersion associated with such Q(f) occurs over unrealistically short frequency range and has an unexpected oscillatory shape. Cases η = 1 and η > 1 are usually attributed to scattering; however, this scattering must exhibit fortuitous tuning into the observation frequency band, which appears unlikely. The reason for the above problems is that the inferred Q values are affected by the conventional single-station measurement procedure. Both parameters Q 0 and are apparent, i.e., dependent on the selected parameterization and inversion method, and they should not be directly attributed to the subsurface. For η ≈ 1, parameter Q 0 actually describes the frequency-independent amplitude decay in access of some assumed geometric spreading t -α , where α is usually taken equal one. The case η > 1 is not allowed physically and could serve as an indicator of problematic interpretations. Although the case 0 < η < 1 is possible, its parameters Q 0 and may also be biased by the measurement procedure. To avoid such difficulties of Q-based approaches, we recommend measuring and interpreting the amplitude-decay rates

  2. Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

    International Nuclear Information System (INIS)

    Talamo, A.; Gohar, Y.; Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C.

    2012-01-01

    The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

  3. Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, A.; Gohar, Y. [Argonne National Laboratory, 9700 S. Cass Ave, Argonne, IL 60439 (United States); Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C. [Joint Inst. for Power and Nuclear Research-Sosny, 99 Academician A.K.Krasin Str, Minsk 220109 (Belarus)

    2012-07-01

    The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

  4. Strategy Iteration Is Strongly Polynomial for 2-Player Turn-Based Stochastic Games with a Constant Discount Factor

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Miltersen, Peter Bro; Zwick, Uri

    2013-01-01

    Ye [2011] showed recently that the simplex method with Dantzig’s pivoting rule, as well as Howard’s policy iteration algorithm, solve discounted Markov decision processes (MDPs), with a constant discount factor, in strongly polynomial time. More precisely, Ye showed that both algorithms terminate...... terminates after at most O(m1−γ log n1−γ) iterations. Second, and more importantly, we show that the same bound applies to the number of iterations performed by the strategy iteration (or strategy improvement) algorithm, a generalization of Howard’s policy iteration algorithm used for solving 2-player turn-based...... for 2-player turn-based stochastic games; it is strongly polynomial for a fixed discount factor, and exponential otherwise....

  5. A load factor based mean-variance analysis for fuel diversification

    Energy Technology Data Exchange (ETDEWEB)

    Gotham, Douglas; Preckel, Paul; Ruangpattana, Suriya [State Utility Forecasting Group, Purdue University, West Lafayette, IN (United States); Muthuraman, Kumar [McCombs School of Business, University of Texas, Austin, TX (United States); Rardin, Ronald [Department of Industrial Engineering, University of Arkansas, Fayetteville, AR (United States)

    2009-03-15

    Fuel diversification implies the selection of a mix of generation technologies for long-term electricity generation. The goal is to strike a good balance between reduced costs and reduced risk. The method of analysis that has been advocated and adopted for such studies is the mean-variance portfolio analysis pioneered by Markowitz (Markowitz, H., 1952. Portfolio selection. Journal of Finance 7(1) 77-91). However the standard mean-variance methodology, does not account for the ability of various fuels/technologies to adapt to varying loads. Such analysis often provides results that are easily dismissed by regulators and practitioners as unacceptable, since load cycles play critical roles in fuel selection. To account for such issues and still retain the convenience and elegance of the mean-variance approach, we propose a variant of the mean-variance analysis using the decomposition of the load into various types and utilizing the load factors of each load type. We also illustrate the approach using data for the state of Indiana and demonstrate the ability of the model in providing useful insights. (author)

  6. “Weak direct” and “Strong indirect” interactions are the mode of action of food factors

    Directory of Open Access Journals (Sweden)

    Tetsuya Konishi

    2014-06-01

    Full Text Available Age-dependent and lifestyle related diseases such as metabolic syndromes have become a social problem worldwide. Since these disorders are closely related to dietary lifestyle, the old saying “foods are medicine” is now being re-evaluated. Thus, dietary protection against these diseases is attracting much attention. As research into functional foods advances, a book of knowledge is being accumulated on the active ingredients, termed “food factors”, present in food resources. Identifying such molecules usually follows the conventional methodology used for finding drug candidates from natural resources. The question has arisen as to whether the mode of action of food factors as molecules is the same as that of drugs. In this article, the functional properties of food factors and drugs are comparatively reviewed and the characteristic features of food factor function is discussed, based on the idea of “weak direct” and “strong indirect” actions of food factors to their receptors

  7. In Situ Loading of Basic Fibroblast Growth Factor Within Porous Silica Nanoparticles for a Prolonged Release

    Directory of Open Access Journals (Sweden)

    Postovit Lynne-Marie

    2009-01-01

    Full Text Available Abstract Basic fibroblast growth factor (bFGF, a protein, plays a key role in wound healing and blood vessel regeneration. However, bFGF is easily degraded in biologic systems. Mesoporous silica nanoparticles (MSNs with well-tailored porous structure have been used for hosting guest molecules for drug delivery. Here, we report an in situ route to load bFGF in MSNs for a prolonged release. The average diameter (d of bFGF-loaded MSNs is 57 ± 8 nm produced by a water-in-oil microemulsion method. The in vitro releasing profile of bFGF from MSNs in phosphate buffer saline has been monitored for 20 days through a colorimetric enzyme linked immunosorbent assay. The loading efficiency of bFGF in MSNs is estimated at 72.5 ± 3%. In addition, the cytotoxicity test indicates that the MSNs are not toxic, even at a concentration of 50 μg/mL. It is expected that the in situ loading method makes the MSNs a new delivery system to deliver protein drugs, e.g. growth factors, to help blood vessel regeneration and potentiate greater angiogenesis.

  8. Skeletal Muscle Depletion and Markers for Cancer Cachexia Are Strong Prognostic Factors in Epithelial Ovarian Cancer.

    Directory of Open Access Journals (Sweden)

    Stefanie Aust

    Full Text Available Tumor cachexia is an important prognostic parameter in epithelial ovarian cancer (EOC. Tumor cachexia is characterized by metabolic and inflammatory disturbances. These conditions might be reflected by body composition measurements (BCMs ascertained by pre-operative computed tomography (CT. Thus, we aimed to identify the prognostically most relevant BCMs assessed by pre-operative CT in EOC patients.We evaluated muscle BCMs and well established markers of nutritional and inflammatory status, as well as clinical-pathological parameters in 140 consecutive patients with EOC. Furthermore, a multiplexed inflammatory marker panel of 25 cytokines was used to determine the relationship of BCMs with inflammatory markers and patient's outcome. All relevant parameters were evaluated in uni- and multivariate survival analysis.Muscle attenuation (MA-a well established BCM parameter-is an independent prognostic factor for survival in multivariate analysis (HR 2.25; p = 0.028. Low MA-reflecting a state of cachexia-is also associated with residual tumor after cytoreductive surgery (p = 0.046 and with an unfavorable performance status (p = 0.015. Moreover, MA is associated with Eotaxin and IL-10 out of the 25 cytokine multiplex marker panel in multivariate linear regression analysis (p = 0.021 and p = 0.047, respectively.MA-ascertained by routine pre-operative CT-is an independent prognostic parameter in EOC patients. Low MA is associated with the inflammatory, as well as the nutritional component of cachexia. Therefore, the clinical value of pre-operative CT could be enhanced by the assessment of MA.

  9. Surface water acidification and critical loads: exploring the F-factor

    Directory of Open Access Journals (Sweden)

    K. Bishop

    2009-11-01

    Full Text Available As acid deposition decreases, uncertainties in methods for calculating critical loads become more important when judgements have to be made about whether or not further emission reductions are needed. An important aspect of one type of model that has been used to calculate surface water critical loads is the empirical F-factor which estimates the degree to which acid deposition is neutralised before it reaches a lake at any particular point in time relative to the pre-industrial, steady-state water chemistry conditions.

    In this paper we will examine how well the empirical F-functions are able to estimate pre-industrial lake chemistry as lake chemistry changes during different phases of acidification and recovery. To accomplish this, we use the dynamic, process-oriented biogeochemical model SAFE to generate a plausible time series of annual runoff chemistry for ca. 140 Swedish catchments between 1800 and 2100. These annual hydrochemistry data are then used to generate empirical F-factors that are compared to the "actual" F-factor seen in the SAFE data for each lake and year in the time series. The dynamics of the F-factor as catchments acidify, and then recover are not widely recognised.

    Our results suggest that the F-factor approach worked best during the acidification phase when soil processes buffer incoming acidity. However, the empirical functions for estimating F from contemporary lake chemistry are not well suited to the recovery phase when the F-factor turns negative due to recovery processes in the soil. This happens when acid deposition has depleted the soil store of BC, and then acid deposition declines, reducing the leaching of base cations to levels below those in the pre-industrial era. An estimate of critical load from water chemistry during recovery and empirical F functions would therefore result in critical loads that are too low. Therefore, the empirical estimates of the F-factor are a significant source of

  10. Effect of Loads and Other Key Factors on Oil-Transformer Ageing: Sustainability Benefits and Challenges

    Directory of Open Access Journals (Sweden)

    Radu Godina

    2015-10-01

    Full Text Available Transformers are one of the more expensive pieces of equipment found in a distribution network. The transformer’s role has not changed over the last decades. With simple construction and at the same time mechanically robust, they offer long term service that on average can reach half a century. Today, with the ongoing trend to supply a growing number of non-linear loads along with the notion of distributed generation (DG, a new challenge has arisen in terms of transformer sustainability, with one of the possible consequences being accelerated ageing. In this paper we carefully review the existing studies in the literature of the effect of loads and other key factors on oil-transformer ageing. The state-of-the-art is reviewed, each factor is analysed in detail, and in the end a smart transformer protection method is sought in order to monitor and protect it from upcoming challenges.

  11. An exact model for airline flight network optimization based on transport momentum and aircraft load factor

    Directory of Open Access Journals (Sweden)

    Daniel Jorge Caetano

    2017-12-01

    Full Text Available The problem of airline flight network optimization can be split into subproblems such as Schedule Generation (SG and Fleet Assignment (FA, solved in consecutive steps or in an integrated way, usually based on monetary costs and revenue forecasts. A linear pro­gramming model to solve SG and FA in an integrated way is presented, but with an al­ternative approach based on transport momentum and aircraft load factor. This alterna­tive approach relies on demand forecast and allows obtaining solutions considering min­imum average load factors. Results of the proposed model applications to instances of a regional Brazilian airline are presented. The comparison of the schedules generated by the proposed approach against those obtained by applying a model based on mone­tary costs and revenue forecasts demonstrates the validity of this alternative approach for airlines network planning.

  12. Assessment of vehicular live load and load factors for design of short-span bridges according to the new Egyptian Code

    Directory of Open Access Journals (Sweden)

    Hatem M. Seliem

    2015-04-01

    The study shows that concrete box-girders designed according to ECP-201:2012 and ECP-201:2003 using the ultimate limit state method yield almost the same demand. Despite the increase in the VLL of ECP-201:2012, and consequently the live load forces, concrete I-shaped girder bridges will be subjected to less total factored internal forces in comparison to ECP-201:2003 This is attributed to the interaction between the live to dead loads ratio and the load combinations. Design of composite steel plate girder bridges according to ECP-201:2012 using the allowable stress design method yields over designed sections.

  13. Evaluation on the Effect of Load Follow Controller's Weighting Factors

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Keuk Jong; Lee, Jae Gon [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    there are several important physical effects that limit the possibilities of power variations in NPPs. Some major effects are moderator and xenon effect. Moderator effect is relation with moderator density change and xenon effect is relation with the concentration change of Xe-135 which could affect axial power shape. These effects are more significant with large magnitudes of power variations and they are considered as major disturbances at the aspect of control method. Due to the above physical effects, it is necessary to carefully change nuclear power considering power distribution change in the core. So, when nuclear plants are required to operate on load variation mode, we could control not only reactor power but also power distribution. Generally, power distribution is controlled by reactor operators who have enough experience, whereas reactor power is automatically controlled by automatic controllers. So, it is necessary to design an automatic controller that controls both reactor power and power distribution for frequent load following operation. Korea Hydro and Nuclear Power Co., LTD (KHNP) has been developing automatic load follow controller as a part of Advanced Power Reactor Plus (APR+) development. The developing controller is composed of three algorithms which could control reactor power and axial power shape. This paper aimed to evaluate the effect of the controller’s weighting factors. So, in this paper, we identify the meaning of the weighting factors and the controlled output weighting factors are selected among them. In this study, the effect of output weighting factors is analyzed. According to the simulation results, it is recommended that the weighting factor of power be between 200 and 400 and that of ASI be between 200 and 600. In the near future, based on the study, optimization of power and ASI weighting factors will be performed at the same time.

  14. Determination of the usage factor of components after cyclic loading using high-resolution microstructural investigations

    International Nuclear Information System (INIS)

    Seibold, A.; Scheibe, A.; Assmann, H.D.

    1989-01-01

    The usage factor can be derived from the quantification of the structure changes and the allocation of the microstructural state to the fatigue curves of the component materials. Using the example of the low alloy fine grain structural steel 20 Mn Mo Ni 5 5 (annealed structure), the relationship between micro-structure and the number of load cycles is shown in the form of a calibration curve. By high resolution structural investigation, the usage factor can be determined to n = N/N B ≅ 0.5 under given vibration stress. Only a small volume sample is required for the electron microscope examination. (orig./DG) [de

  15. Field Study of Live Load Distribution Factors and Dynamic Load Allowance on Reinforced Concrete T-Beam Bridges

    National Research Council Canada - National Science Library

    Trimble, Matthew

    2003-01-01

    .... The vehicle under consideration in this study was a U.S. Army Palletized Loading System (PLS) military vehicle. Results from this evaluation were compared to those obtained from a civilian dump truck owned by the Virginia Department of Transportation...

  16. Factors influencing the potential for strong brand relationships with consumer product brands: An overview and research agenda

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Bergkvist, Lars; Francis, Julie

    Based on the premise that consumer product brands are different with respect to their potential to form strong long-term relationships with consumers, this paper aims to identify factors that influence brands' potential for strong long-term relationships and to suggest how these can be empirically...... investigated. The paper reviews brand-centric and consumer-centric research and identifies twelve brand variables that may influence the relationship potential of consumer product brands. A research agenda is suggested and a number of issues that needs to be resolved before empirical research can be carried...... out are discussed. The paper concludes by speculating on possible outcomes in future empirical studies and it is suggested that multiple brand variables will have to be employed to evaluate the relationship potential of brands....

  17. Dutch monitor on stress and physical load: risk factors, consequences, and preventive action.

    Science.gov (United States)

    Houtman, I L; Goudswaard, A; Dhondt, S; van der Grinten, M P; Hildebrandt, V H; van der Poel, E G

    1998-02-01

    Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational and environmental variables that facilitate preventive actions. Information was gathered from employers, employees, and employees' representatives. The monitor was used with a nationally representative sample of companies in industry, wholesale trade, and banking and finance, 782 companies in total. The information from the employees, aggregated at the company level, was not found to be correlated with that from the employer from the same companies. Although many employers do recognise risk factors for both physical load and stress as a problem they often seem to underestimate the problem when compared with employees or their representatives. This is particularly the case for psychosocial risk factors. Also, the perception of outcome measures, especially employers who consider emotional exhaustion to be work related, were fewer than the employees' representatives of the same organisation. Preventive measures on physical load are much more popular than measures against stress. It is the responsibility of the employer to take more preventive action of all kinds. They need to recognise risk factors as problems and health outcomes to be related to work. Employees of larger companies should participate with employers to consider effective measures, and more use should be made of support at branch level. For specific preventive measures, specific predictors emerged. Except for measures to prevent work stress, information from employees did not sufficiently contribute to the initiation of preventive measures in the workplace.

  18. Strategy iteration is strongly polynomial for 2-player turn-based stochastic games with a constant discount factor

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Miltersen, Peter Bro; Zwick, Uri

    2011-01-01

    Ye showed recently that the simplex method with Dantzig pivoting rule, as well as Howard's policy iteration algorithm, solve discounted Markov decision processes (MDPs), with a constant discount factor, in strongly polynomial time. More precisely, Ye showed that both algorithms terminate after...... iterations. Second, and more importantly, we show that the same bound applies to the number of iterations performed by the strategy iteration (or strategy improvement) algorithm, a generalization of Howard's policy iteration algorithm used for solving 2-player turn-based stochastic games with discounted zero...

  19. A ChIP-Seq benchmark shows that sequence conservation mainly improves detection of strong transcription factor binding sites.

    Directory of Open Access Journals (Sweden)

    Tony Håndstad

    Full Text Available BACKGROUND: Transcription factors are important controllers of gene expression and mapping transcription factor binding sites (TFBS is key to inferring transcription factor regulatory networks. Several methods for predicting TFBS exist, but there are no standard genome-wide datasets on which to assess the performance of these prediction methods. Also, it is believed that information about sequence conservation across different genomes can generally improve accuracy of motif-based predictors, but it is not clear under what circumstances use of conservation is most beneficial. RESULTS: Here we use published ChIP-seq data and an improved peak detection method to create comprehensive benchmark datasets for prediction methods which use known descriptors or binding motifs to detect TFBS in genomic sequences. We use this benchmark to assess the performance of five different prediction methods and find that the methods that use information about sequence conservation generally perform better than simpler motif-scanning methods. The difference is greater on high-affinity peaks and when using short and information-poor motifs. However, if the motifs are specific and information-rich, we find that simple motif-scanning methods can perform better than conservation-based methods. CONCLUSIONS: Our benchmark provides a comprehensive test that can be used to rank the relative performance of transcription factor binding site prediction methods. Moreover, our results show that, contrary to previous reports, sequence conservation is better suited for predicting strong than weak transcription factor binding sites.

  20. Analytical Dancoff factor evaluations for reactor designs loaded with TRISO particle fuel

    International Nuclear Information System (INIS)

    Ji, Wei; Liang, Chao; Pusateri, Elise N.

    2014-01-01

    Highlights: • The Dancoff factors for randomly distributed TRISO fuel particles are evaluated. • A new “dual-sphere” model is proposed to predict Dancoff factors. • The new model accurately accounts for the coating regions of fuel particles. • High accuracy is achieved over a broad range of design parameters. • The new model can be used to analyze reactors with double heterogeneity. - Abstract: A new mathematical model, the dual-sphere model, is proposed to analytically evaluate Dancoff factors of TRISO fuel kernels based on the chord method. The accurate evaluation of fuel kernel Dancoff factors is needed when one analyzes nuclear reactors loaded with TRISO particle fuel. In these reactor designs, fuel kernels are randomly distributed and shield each other, causing a shadowing effect. The Dancoff factor is a quantitative measure of this effect and is determined by the spatial distribution of fuel kernels. A TRISO fuel particle usually consists of four layers that form a coating region outside the fuel kernel. When fuel particles are loaded in the reactor, the spatial distribution of fuel kernels can be affected by the thickness of the coating region. Therefore, the coating region should be taken into account in the calculation of Dancoff factors. However, the previous model, the single-sphere model, assumes no coating regions in the Dancoff factor predictions. To address this model deficiency, the dual-sphere model is proposed by deriving a new chord length distribution function between two fuel kernels that explicitly accounts for coating regions. The new model is employed to derive analytical solutions of infinite medium, intra-fuel pebble and intra-fuel compact/pin Dancoff factors over a wide range of volume packing fractions of TRISO fuel particles, varying from 2% to 60%. Comparisons are made with the predictions from the single-sphere model and reference Monte Carlo simulations. A significant improvement of the accuracy, over the ranges of

  1. Deep subsurface structure modeling and site amplification factor estimation in Niigata plain for broadband strong motion prediction

    International Nuclear Information System (INIS)

    Sato, Hiroaki

    2009-01-01

    This report addresses a methodology of deep subsurface structure modeling in Niigata plain, Japan to estimate site amplification factor in the broadband frequency range for broadband strong motion prediction. In order to investigate deep S-wave velocity structures, we conduct microtremor array measurements at nine sites in Niigata plain, which are important to estimate both long- and short-period ground motion. The estimated depths of the top of the basement layer agree well with those of the Green tuff formation as well as the Bouguer anomaly distribution. Dispersion characteristics derived from the observed long-period ground motion records are well explained by the theoretical dispersion curves of Love wave group velocities calculated from the estimated subsurface structures. These results demonstrate the deep subsurface structures from microtremor array measurements make it possible to estimate long-period ground motions in Niigata plain. Moreover an applicability of microtremor array exploration for inclined basement structure like a folding structure is shown from the two dimensional finite difference numerical simulations. The short-period site amplification factors in Niigata plain are empirically estimated by the spectral inversion analysis from S-wave parts of strong motion data. The resultant characteristics of site amplification are relative large in the frequency range of about 1.5-5 Hz, and decay significantly with the frequency increasing over about 5 Hz. However, these features can't be explained by the calculations from the deep subsurface structures. The estimation of site amplification factors in the frequency range of about 1.5-5 Hz are improved by introducing a shallow detailed structure down to GL-20m depth at a site. We also propose to consider random fluctuation in a modeling of deep S-wave velocity structure for broadband site amplification factor estimation. The Site amplification in the frequency range higher than about 5 Hz are filtered

  2. Psychobehavioural Factors Are More Strongly Associated with Successful Weight Management Than Predetermined Satiety Effect or Other Characteristics of Diet

    Directory of Open Access Journals (Sweden)

    Leila Karhunen

    2012-01-01

    Full Text Available This study aimed to investigate factors associated with weight management, especially whether satiety value of food as a part of a weight-maintenance diet would affect self-regulation of food intake and weight management. Altogether 82 obese subjects completed the study consisting of weight-loss and weight-maintenance (WM periods. During the WM, subjects were randomized into higher- and lower-satiety food groups. No differences were observed in the changes in body weight, energy intake, or eating behaviour between the groups, even despite the different macronutrient compositions of the diets. However, when regarding all study subjects, success in WM was most strongly associated with a greater increase in the flexible control of eating and experience of greater easiness of WM and control of food intake and a greater decrease in uncontrollable eating and psychological distress. Psychobehavioural factors seem to be more strongly associated with successful weight management than the predetermined satiety effect or other characteristics of the diet.

  3. Stress-intensity factors for cracks emanating from the loaded fastener hole

    Science.gov (United States)

    Shivakumar, V.; Hsu, Y. C.

    1977-01-01

    Using a series approach and the Muskhelishvili formulation in the two-dimensional theory of elasticity, stress-intensity factors K are derived for problems in which cracks emanate radially from the boundary of an arbitrarily loaded internal circular hole in an infinite plate. Numerical values are obtained for K(I) and K(II) for radial cracks from a hole containing a loose-fitted pin or rivet that is pulled perpendicular to the crack direction in the plane of the plate. The method is a general one for determining K for a set of symmetrically emanating radial cracks for a variety of concentrated or distributed tractions on the circular hole.

  4. An estimation of finger-tapping rates and load capacities and the effects of various factors.

    Science.gov (United States)

    Ekşioğlu, Mahmut; İşeri, Ali

    2015-06-01

    The aim of this study was to estimate the finger-tapping rates and finger load capacities of eight fingers (excluding thumbs) for a healthy adult population and investigate the effects of various factors on tapping rate. Finger-tapping rate, the total number of finger taps per unit of time, can be used as a design parameter of various products and also as a psychomotor test for evaluating patients with neurologic problems. A 1-min tapping task was performed by 148 participants with maximum volitional tempo for each of eight fingers. For each of the tapping tasks, the participant with the corresponding finger tapped the associated key in the standard position on the home row of a conventional keyboard for touch typing. The index and middle fingers were the fastest fingers for both hands, and little fingers the slowest. All dominant-hand fingers, except little finger, had higher tapping rates than the fastest finger of the nondominant hand. Tapping rate decreased with age and smokers tapped faster than nonsmokers. Tapping duration and exercise had also significant effect on tapping rate. Normative data of tapping rates and load capacities of eight fingers were estimated for the adult population. In designs of psychomotor tests that require the use of tapping rate or finger load capacity data, the effects of finger, age, smoking, and tapping duration need to be taken into account. The findings can be used for ergonomic designs requiring finger-tapping capacity and also as a reference in psychomotor tests. © 2015, Human Factors and Ergonomics Society.

  5. Psychobehavioural Factors Are More Strongly Associated with Successful Weight Management Than Predetermined Satiety Effect or Other Characteristics of Diet

    DEFF Research Database (Denmark)

    Karhunen, Leila; Lyly, Marika; Lapveteläinen, Anja

    2012-01-01

    This study aimed to investigate factors associated with weight management, especially whether satiety value of food as a part of a weight-maintenance diet would affect self-regulation of food intake and weight management. Altogether 82 obese subjects completed the study consisting of weight....... However, when regarding all study subjects, success in WM was most strongly associated with a greater increase in the flexible control of eating and experience of greater easiness of WM and control of food intake and a greater decrease in uncontrollable eating and psychological distress. Psychobehavioural......-loss and weight-maintenance (WM) periods. During theWM, subjects were randomized into higher- and lower-satiety food groups. No differences were observed in the changes in body weight, energy intake, or eating behaviour between the groups, even despite the different macronutrient compositions of the diets...

  6. Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

    Energy Technology Data Exchange (ETDEWEB)

    Nandi, Samit K., E-mail: samitnandi1967@gmail.com [Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata (India); Kundu, Biswanath, E-mail: biswa_kundu@rediffmail.com [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India); Basu, Debabrata [Bioceramics and Coating Division, CSIR—Central Glass and Ceramic Research Institute, Kolkata (India)

    2013-04-01

    Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85 ± 2%) with wide distribution of macroporous (70–900 μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87 ± 2 and 90 ± 2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples. - Highlights: ► Fabrication and characterization of porous chitosan with or without IGF-1 and BMP-2 ► Highly porous growth factor loaded chitosan studied in animal subjects for 3 months ► Parameters studied: histopathology, radiology and fluorochrome labeling ► IGF-1 loaded porous chitosan found to be very effective for bone defect healing.

  7. Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

    International Nuclear Information System (INIS)

    Nandi, Samit K.; Kundu, Biswanath; Basu, Debabrata

    2013-01-01

    Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85 ± 2%) with wide distribution of macroporous (70–900 μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87 ± 2 and 90 ± 2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples. - Highlights: ► Fabrication and characterization of porous chitosan with or without IGF-1 and BMP-2 ► Highly porous growth factor loaded chitosan studied in animal subjects for 3 months ► Parameters studied: histopathology, radiology and fluorochrome labeling ► IGF-1 loaded porous chitosan found to be very effective for bone defect healing

  8. Switch Panel wear loading - a parametric study regarding governing train operational factors

    Science.gov (United States)

    Hiensch, E. J. M.; Burgelman, N.

    2017-09-01

    The acting forces and resulting material degradation at the running surfaces of wheels and rail are determined by vehicle, track, interface and operational characteristics. To effectively manage the experienced wear, plastic deformation and crack development at wheels and rail, the interaction between vehicle and track demands a system approach both in maintenance and in design. This requires insight into the impact of train operational parameters on rail- and wheel degradation, in particular at switches and crossings due to the complex dynamic behaviour of a railway vehicle at a turnout. A parametric study was carried out by means of vehicle-track simulations within the VAMPIRE® multibody simulation software, performing a sensitivity analysis regarding operational factors and their impact on expected switch panel wear loading. Additionally, theoretical concepts were cross-checked with operational practices by means of a case study in response to a dramatic change in lateral rail wear development at specific switches in Dutch track. Data from train operation, track maintenance and track inspection were analysed, providing further insight into the operational dependencies. From the simulations performed in this study, it was found that switch rail lateral wear loading at the diverging route of a 1:9 type turnout is significantly influenced by the level of wheel-rail friction and to a lesser extent by the direction of travel (facing or trailing). The influence of other investigated parameters, being vehicle speed, traction, gauge widening and track layout is found to be small. Findings from the case study further confirm the simulation outcome. This research clearly demonstrates the contribution flange lubrication can have in preventing abnormal lateral wear at locations where the wheel-rail interface is heavily loaded.

  9. Building and environmental factors that influence bacterial and fungal loading on air conditioning cooling coils.

    Science.gov (United States)

    Bakker, A; Siegel, J A; Mendell, M J; Peccia, J

    2018-05-30

    We investigated bacterial and fungal concentrations on cooling coils of commercial AC units and quantified associations between microbial loads and AC unit or building operational parameters. A field campaign was conducted to sample 25 AC units in the humid, subtropical climate of Southern CT, USA and 15 AC units in the hot-summer Mediterranean climate of Sacramento, CA, USA. Median concentrations (with interquartile range) of bacteria and fungi on the cooling coils were 1.2 × 10 7 (5.1 × 10 6 -3.9 × 10 7 ) cells/m 2 and 7.6 × 10 5 (5.6 × 10 4 -4.4 × 10 6 ) spore equivalents (SE)/m 2 , respectively. Concentrations varied among units with median unit concentrations ranging three orders of magnitude for bacteria and seven orders of magnitude for fungi. Controlled comparisons and multivariable regressions indicate that dominant factors associated with AC coil loading include the nominal efficiency of upstream filters (P = .008 for bacteria and P < .001 for fungi) and coil moisture, which was reflected in fungal loading differences between top and bottom halves of the AC coils in Southern CT (P = .05) and the dew points of the two climates considered (P = .04). Environmental and building characteristics explained 42% (P < .001) of bacterial concentration variability and 66% (P < .001) of fungal concentration variability among samples. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Debora Faraone

    2009-08-01

    Full Text Available Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived growth factor receptors (PDGF-Rs is reported to be reduced in metastatic melanoma compared with benign nevi or normal skin; we then hypothesized that PDGF-Rα may control growth of melanoma cells. We show here that melanoma cells overexpressing PDGF-Rα respond to serum with a significantly lower proliferation compared with that of controls. Apoptosis, cell cycle arrest, pRb dephosphorylation, and DNA synthesis inhibition were also observed in cells overexpressing PDGF-Rα. Proliferation was rescued by PDGF-Rα inhibitors, allowing to exclude nonspecific toxic effects and indicating that PDGF-Rα mediates autocrine antiproliferation signals in melanoma cells. Accordingly, PDGF-Rα was found to mediate staurosporine cytotoxicity. A protein array-based analysis of the mitogen-activated protein kinase pathway revealed that melanoma cells overexpressing PDGF-Rα show a strong reduction of c-Jun phosphorylated in serine 63 and of protein phosphatase 2A/Bα and a marked increase of p38γ, mitogen-activated protein kinase kinase 3, and signal regulatory protein α1 protein expression. In a mouse model of primary melanoma growth, infection with the Ad-vector overexpressing PDGF-Rα reached a significant 70% inhibition of primary melanoma growth (P < .001 and a similar inhibition of tumor angiogenesis. All together, these data demonstrate that PDGF-Rα strongly impairs melanoma growth likely through autocrine mechanisms and indicate a novel endogenous mechanism involved in melanoma control.

  11. Process for improving the load factor of an electricity generating power station

    International Nuclear Information System (INIS)

    Rostaing, Michel.

    1974-01-01

    A description is given of a process for improving the load factor of an electricity generating power station feeding a supply network in which all or part of the power not required by the network during off-peak hours is used for producing hydrogen which is then stored. The stored hydrogen is then burned and the heat generated is employed for superheating the steam generated by the nuclear reactor of the power plant. This combustion is carried out permanently. The hydrogen is produced by water electrolysis. The oxygen also produced in this manner is used as a comburent in the combustion of the hydrogen. The reactor is of the pressurized water type [fr

  12. Stress intensity factors of eccentric cracks in bi-materials plate under mode I loading

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, A. E. [Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn Malaysia, 86400 Batu Pahat, Johor (Malaysia)

    2015-05-15

    Bi-material plates were generally used to joint electronic devices or mechanical components requiring dissimilar materials to be attached. During services, mechanical failure can be occurred due to the formation of cracks at the interfacial joint or away from the centre. Generally, linear elastic fracture mechanics approach is used to characterize these cracks based on stress intensity factors (SIF). Based on the literature survey, the SIFs for the central cracks were easily available. However, the SIFs for eccentric cracks were difficult to obtain. Therefore, this paper presented the SIFs for eccentric cracks subjected to mode I tension loading. Three important parameters were used such as relative crack depth, a/L, relative offset distance, b/L and elastic mismatch, E{sub 1}/E{sub 2} or α. It was found that such parameters significantly affected the characteristic of SIFs and it was depend on the location of cracks.

  13. Assessment of Various Risk Factors for Success of Delayed and Immediate Loaded Dental Implants: A Retrospective Analysis.

    Science.gov (United States)

    Prasant, M C; Thukral, Rishi; Kumar, Sachin; Sadrani, Sannishth M; Baxi, Harsh; Shah, Aditi

    2016-10-01

    Ever since its introduction in 1977, a minimum of few months of period is required for osseointegration to take place after dental implant surgery. With the passage of time and advancements in the fields of dental implant, this healing period is getting smaller and smaller. Immediate loading of dental implants is becoming a very popular procedure in the recent time. Hence, we retrospectively analyzed the various risk factors for the failure of delayed and immediate loaded dental implants. In the present study, retrospective analysis of all the patients was done who underwent dental implant surgeries either by immediate loading procedure or by delayed loading procedures. All the patients were divided broadly into two groups with one group containing patients in which delayed loaded dental implants were placed while other consisted of patients in whom immediate loaded dental implants were placed. All the patients in whom follow-up records were missing and who had past medical history of any systemic diseases were excluded from the present study. Evaluation of associated possible risk factors was done by classifying the predictable factors as primary and secondary factors. All the results were analyzed by Statistical Package for the Social Sciences (SPSS) software. Kaplan-Meier survival analyses and chi-square test were used for assessment of level of significance. In delayed and immediate group of dental implants, mean age of the patients was 54.2 and 54.8 years respectively. Statistically significant results were obtained while comparing the clinical parameters of the dental implants in both the groups while demographic parameters showed nonsignificant correlation. Significant higher risk of dental implant failure is associated with immediate loaded dental implants. Tobacco smoking, shorter implant size, and other risk factors play a significant role in predicting the success and failure of dental implants. Delayed loaded dental implant placement should be preferred

  14. The fate of 131I-17-iodoheptadecanoic acid during lactate loading: Its oxidation is strongly inhibited in favor of its esterification

    International Nuclear Information System (INIS)

    Duwel, C.M.B.; Visser, F.C.; Eenige, M.J. van; Roos, J.P.; Hollander, W. den

    1990-01-01

    The influence of lactate loading on fatty acid metabolism (pH = 7.4) by the normal canine heart was investigated radiochemically using the radioiodinated fatty acid 131 I-17-iodoheptadecanoic acid ( 131 I-17-HDA). Fatty acid metabolism was studied during control conditions (n = 8) and after lactate loading (n = 7). In the canine heart total myocardial 131 I-17-HDA radioactivity (uptake) was not changed during the lactate intervention. The oxidation decreased fivefold (measured as free 131 I-iodide ion) from 70% to 14% (p 131 I-17-HDA was mainly stored in the triglycerides and phosphoglycerides. These results suggest that lactate inhibits cardiac 131 I-HDA oxidation. (orig.) [de

  15. Fisher Information Based Meteorological Factors Introduction and Features Selection for Short-Term Load Forecasting

    Directory of Open Access Journals (Sweden)

    Shuping Cai

    2018-03-01

    Full Text Available Weather information is an important factor in short-term load forecasting (STLF. However, for a long time, more importance has always been attached to forecasting models instead of other processes such as the introduction of weather factors or feature selection for STLF. The main aim of this paper is to develop a novel methodology based on Fisher information for meteorological variables introduction and variable selection in STLF. Fisher information computation for one-dimensional and multidimensional weather variables is first described, and then the introduction of meteorological factors and variables selection for STLF models are discussed in detail. On this basis, different forecasting models with the proposed methodology are established. The proposed methodology is implemented on real data obtained from Electric Power Utility of Zhenjiang, Jiangsu Province, in southeast China. The results show the advantages of the proposed methodology in comparison with other traditional ones regarding prediction accuracy, and it has very good practical significance. Therefore, it can be used as a unified method for introducing weather variables into STLF models, and selecting their features.

  16. Human Factors Evaluation of the Modular Lightweight Load-Carrying Equipment (MOLLE) System

    National Research Council Canada - National Science Library

    Sampson, James

    2001-01-01

    .... The FEA was used in drafting a new user requirements document and initiating the development of a modular load-carrying system which ultimately became known as the Modular Lightweight Load-carrying Equipment (MOLLE...

  17. Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen

    Directory of Open Access Journals (Sweden)

    Junmin Lai

    2017-02-01

    Full Text Available The aim of the study was to investigate the effects of the loading factors, i.e., the initial drug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical performance of drug-loaded mesoporous systems. Ibuprofen (IBU was used as a model drug, and two non-ordered mesoporous materials of commercial silica Syloid® 244FP (S244FP and Neusilin® US2 (NS2 were selected in the study. The IBU-loaded mesoporous samples were prepared by a solvent immersion method with a rotary evaporation drying technique and characterized by polarized light microscopy (PLM, Fourier transform infrared (FTIR spectroscopy, X-ray powder diffraction (XRPD and differential scanning calorimetry (DSC. Dissolution experiments were performed in simulated gastric media at 37 °C under non-sink conditions. The concentration of IBU in solution was determined by HPLC. The study showed that the dissolution rate of IBU can be improved significantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into the amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the molecular interaction between the IBU and NS2 carriers, the loading factors had little effects on the drug release kinetics with incomplete drug desorption recovery and insignificant dissolution enhancement. Care and extensive evaluation must therefore be taken when mesoporous materials are chosen as carrier delivery systems.

  18. Relation of Adiponectin to Glucose Tolerance Status, Adiposity, and Cardiovascular Risk Factor Load

    Directory of Open Access Journals (Sweden)

    N. Wolfson

    2012-01-01

    Full Text Available Objective. Adiponectin has anti-atherogenic and anti-inflammatory properties. We investigated the influence of adiponectin on glucose tolerance status, adiposity and cardiovascular risk factors (CVRFs. Design and Patients. Study consisted of 107 subjects: 55 with normal glucose tolerance (NGT and 52 with impaired glucose regulation (IGR who were divided into two groups: 24 subjects with impaired fasting glucose (IFG Group and 28 patients with type 2 diabetes mellitus (DM Group. In additional analysis, study participants were divided into two groups, according to CVRFs: low and high risk. Measurements: Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin. Measurements. Patients were evaluated for glucose, HbA1C, insulin, lipids, CRP, HOMA-IR and adiponectin. Results. Adiponectin was significantly higher in NGT group than in IFG (=0.003 and DM (=0.01 groups. Adiponectin was significantly, positively associated with HDL and inversely associated with glucose, HbA1c, ALT, AST, TG, HOMA-IR. Patients with higher CVRFs load have lesser adiponectin compared to patients with low cardiovascular risk <0.0001. Adiponectin was inversely associated with the number of risk factors (=−0.430, =0.0001. Conclusions. Circulating adiponectin was significantly lower in subjects with different degree of IGR compared to subjects with normal glucose homeostasis. Adiponectin was significantly lower in high risk group than low risk group and decreased concurrently with increased number of CVRFs.

  19. Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load.

    Science.gov (United States)

    Attonito, Jennifer; Dévieux, Jessy G; Lerner, Brenda D G; Hospital, Michelle M; Rosenberg, Rhonda

    2014-01-01

    Psychosocial factors may directly impact HIV health measures such as viral load (VL) whether or not patients are taking antiretroviral treatment (ART) consistently. Structural equation modeling plus Baron and Kenny's (1986) four-step approach were used to test a mediated model predicting VL among 246 HIV-infected adults who were on ART. Exogenous variables were social support, barriers to adherence, and stress. Moderators were alcohol use, marijuana use, and neurocognitive impairment. A small positive association between marijuana use and ART adherence approached significance. Only barriers to adherence predicted a decrease in adherence rates and an increase in VL. No other factors were significantly associated with either VL or adherence, and no interaction effects between exogenous variables and moderators were identified. The association between barriers to adherence and VL was partially mediated by ART adherence. Findings provide modest support for a direct link between psychosocial variables and a virologic response to ART. Copyright © 2014 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

  20. Influential Factors for Accurate Load Prediction in a Demand Response Context

    DEFF Research Database (Denmark)

    Wollsen, Morten Gill; Kjærgaard, Mikkel Baun; Jørgensen, Bo Nørregaard

    2016-01-01

    Accurate prediction of a buildings electricity load is crucial to respond to Demand Response events with an assessable load change. However, previous work on load prediction lacks to consider a wider set of possible data sources. In this paper we study different data scenarios to map the influence....... Next, the time of day that is being predicted greatly influence the prediction which is related to the weather pattern. By presenting these results we hope to improve the modeling of building loads and algorithms for Demand Response planning.......Accurate prediction of a buildings electricity load is crucial to respond to Demand Response events with an assessable load change. However, previous work on load prediction lacks to consider a wider set of possible data sources. In this paper we study different data scenarios to map the influence...

  1. The use of simulated rainfall to study the discharge process and the influence factors of urban surface runoff pollution loads.

    Science.gov (United States)

    Qinqin, Li; Qiao, Chen; Jiancai, Deng; Weiping, Hu

    2015-01-01

    An understanding of the characteristics of pollutants on impervious surfaces is essential to estimate pollution loads and to design methods to minimize the impacts of pollutants on the environment. In this study, simulated rainfall equipment was constructed to investigate the pollutant discharge process and the influence factors of urban surface runoff (USR). The results indicated that concentrations of total suspended solids (TSS), total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (COD) appeared to be higher in the early period and then decreased gradually with rainfall duration until finally stabilized. The capacity and particle size of surface dust, rainfall intensity and urban surface slopes affected runoff pollution loads to a variable extent. The loads of TP, TN and COD showed a positive relationship with the surface dust capacity, whereas the maximum TSS load appeared when the surface dust was 0.0317 g·cm⁻². Smaller particle sizes (pollution carrying capacity of runoff, leading to higher pollution loads. Knowledge of the influence factors could assist in the management of USR pollution loads.

  2. Weak and strong factorization properties in nucleus-nucleus collisions in the energy region 290-2100 MeV/nucleon

    International Nuclear Information System (INIS)

    La Tessa, C. . E-mail chiara@nephy.chalmers.se; Sihver, L.; Mancusi, D.; Zeitlin, C.; Miller, J.; Guetersloh, S.; Heilbronn, L.

    2007-01-01

    We have collected from the literature partial charge-changing cross sections for projectiles with charge 6=< Z=<26, energy ranging from 290 up to 2100 MeV/nucleon and interacting with several targets, in order to investigate weak and strong factorization properties. The same analysis methods as in our previous work have been applied to the data: we have shown that, except for hydrogen targets, weak and strong factorization properties are valid within 5%, thus confirming the results obtained in the first paper [C. La Tessa, et al., Test of weak and strong factorization in nucleus-nucleus collisions at several hundred MeV/nucleon, Nucl. Phys. A, in press]. Factorization parameters have been calculated and, in particular, target factors have been expressed with ad hoc analytical functions which describe the data trend very well. New expressions for weak and strong factorization properties can then be obtained by substituting the target factors with these functions: this formulation partially isolates the dependence of the partial charge-changing cross sections on the target and projectile mass numbers; moreover, fragment factors are the only parameters left in the formulas thus facilitating the future task of interpolating them with appropriate analytical expressions

  3. Nearshore hydrodynamics as loading and forcing factors for Escherichia coli contamination at an embayed beach

    Science.gov (United States)

    Ge, Zhongfu; Whitman, Richard L.; Nevers, Meredith B.; Phanikumar, Mantha S.; Byappanahalli, Muruleedhara N.

    2012-01-01

    Numerical simulations of the transport and fate of Escherichia coli were conducted at Chicago's 63rd Street Beach, an embayed beach that had the highest mean E. coli concentration among 23 similar Lake Michigan beaches during summer months of 2000-2005, in order to find the cause for the high bacterial contamination. The numerical model was based on the transport of E. coli by current circulation patterns in the embayment driven by longshore main currents and the loss of E. coli in the water column, taking settling as well as bacterial dark- and solar-related decay into account. Two E. coli loading scenarios were considered: one from the open boundary north of the embayment and the other from the shallow water near the beachfront. Simulations showed that the embayed beach behaves as a sink for E. coli in that it generally receives E. coli more efficiently than it releases them. This is a result of the significantly different hydrodynamic forcing factors between the inside of the embayment and the main coastal flow outside. The settled E. coli inside the embayment can be a potential source of contamination during subsequent sediment resuspension events, suggesting that deposition-resuspension cycles of E. coli have resulted in excessive bacterial contamination of beach water. A further hypothetical case with a breakwater shortened to half its original length, which was anticipated to enhance the current circulation in the embayment, showed a reduction in E. coli concentrations of nearly 20%.

  4. Evaluation of Dynamic Load Factors for a High-Speed Railway Truss Arch Bridge

    Directory of Open Access Journals (Sweden)

    Ding Youliang

    2016-01-01

    Full Text Available Studies on dynamic impact of high-speed trains on long-span bridges are important for the design and evaluation of high-speed railway bridges. The use of the dynamic load factor (DLF to account for the impact effect has been widely accepted in bridge engineering. Although the field monitoring studies are the most dependable way to study the actual DLF of the bridge, according to previous studies there are few field monitoring data on high-speed railway truss arch bridges. This paper presents an evaluation of DLF based on field monitoring and finite element simulation of Nanjing DaShengGuan Bridge, which is a high-speed railway truss arch bridge with the longest span throughout the world. The DLFs in different members of steel truss arch are measured using monitoring data and simulated using finite element model, respectively. The effects of lane position, number of train carriages, and speed of trains on DLF are further investigated. By using the accumulative probability function of the Generalized Extreme Value Distribution, the probability distribution model of DLF is proposed, based on which the standard value of DLF within 50-year return period is evaluated and compared with different bridge design codes.

  5. Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A

    Science.gov (United States)

    Lee, Hyun Woong; Chang, Dong-Yeop; Moon, Hong Ju; Chang, Hye Young; Shin, Eui-Cheol; Lee, June Sung; Kim, Kyung-Ah; Kim, Hyung Joon

    2015-01-01

    Background and Aims Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, and clinical outcomes in patients with acute hepatitis A (AHA) and evaluated predictive factors for severe acute hepatitis (s-AH). Methods We analyzed the clinical manifestations of AHA in 770 patients. Patients with a prothrombin time (PT) of less than 40% of normal were classified as s-AH and included 4 patients with FHF, 11 patients with acute renal failure, and 3 patients with prolonged jaundice (n = 128). Other patients were defined as mild acute hepatitis (m-AH) (n = 642). Serum samples were obtained from 48 patients with acute hepatitis A. Among them, 20 with s-AH, and 28 with m-AH, were tested for HAV RNA titer. Results In a multivariate analysis, age (HR = 1.042, P = 0.041), peak creatinine (HR = 4.014, P = 0.001), bilirubin (HR = 1.153, P = 0.003), alanine aminotransferase (ALT) (HR = 1.001, Phepatitis A. PMID:26090677

  6. Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A.

    Science.gov (United States)

    Lee, Hyun Woong; Chang, Dong-Yeop; Moon, Hong Ju; Chang, Hye Young; Shin, Eui-Cheol; Lee, June Sung; Kim, Kyung-Ah; Kim, Hyung Joon

    2015-01-01

    Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, and clinical outcomes in patients with acute hepatitis A (AHA) and evaluated predictive factors for severe acute hepatitis (s-AH). We analyzed the clinical manifestations of AHA in 770 patients. Patients with a prothrombin time (PT) of less than 40% of normal were classified as s-AH and included 4 patients with FHF, 11 patients with acute renal failure, and 3 patients with prolonged jaundice (n = 128). Other patients were defined as mild acute hepatitis (m-AH) (n = 642). Serum samples were obtained from 48 patients with acute hepatitis A. Among them, 20 with s-AH, and 28 with m-AH, were tested for HAV RNA titer. In a multivariate analysis, age (HR = 1.042, P = 0.041), peak creatinine (HR = 4.014, P = 0.001), bilirubin (HR = 1.153, P = 0.003), alanine aminotransferase (ALT) (HR = 1.001, P hepatitis A.

  7. Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

    Science.gov (United States)

    Muniz Terrera, Graciela; Keage, Hannah; Rahkonen, Terhi; Oinas, Minna; Matthews, Fiona E.; Cunningham, Colm; Polvikoski, Tuomo; Sulkava, Raimo; MacLullich, Alasdair M. J.; Brayne, Carol

    2012-01-01

    .1–3.5, P = 0.02), but in those with a history of delirium, there was no significant relationship (odds ratio 1.2, 95% confidence interval 0.2–6.7, P = 0.85). This trend for odds ratios to be closer to unity in the delirium and dementia group was observed for neuritic amyloid, apolipoprotein ε status, presence of infarcts, α-synucleinopathy and neuronal loss in substantia nigra. These findings are the first to demonstrate in a true population study that delirium is a strong risk factor for incident dementia and cognitive decline in the oldest-old. However, in this study, the relationship did not appear to be mediated by classical neuropathologies associated with dementia. PMID:22879644

  8. Dutch monitor on stress and physical load : risk factors, consequences, and preventive action

    NARCIS (Netherlands)

    Houtman, I.L.D.; Goudswaard, A.; Dhondt, S.; Grinten, M.P. van der; Hildebrandt, V.H.; Poel, E.G.T. van der

    1998-01-01

    Objectives - Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks,

  9. Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration.

    Science.gov (United States)

    Yu, Ting; Xu, Bei; He, Lili; Xia, Shan; Chen, Yan; Zeng, Jun; Liu, Yongmei; Li, Shuangzhi; Tan, Xiaoyue; Ren, Ke; Yao, Shaohua; Song, Xiangrong

    2016-01-01

    Anti-angiogenesis has been proposed as an effective therapeutic strategy for cancer treatment. Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous anti-angiogenic reagents discovered to date and PEDF gene therapy has been recognized as a promising treatment option for various tumors. There is an urgent need to develop a safe and valid vector for its systemic delivery. Herein, a novel gene delivery system based on the newly synthesized copolymer COOH-PEG-PLGA-COOH (CPPC) was developed in this study, which was probably capable of overcoming the disadvantages of viral vectors and cationic lipids/polymers-based nonviral carriers. PEDF gene loaded CPPC nanoparticles (D-NPs) were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W) solvent evaporation method. D-NPs with uniform spherical shape had relatively high drug loading (~1.6%), probably because the introduced carboxyl group in poly (D,L-lactide-co-glycolide) terminal enhanced the interaction of copolymer with the PEDF gene complexes. An excellent in vitro antitumor effect was found in both C26 and A549 cells treated by D-NPs, in which PEDF levels were dramatically elevated due to the successful transfection of PEDF gene. D-NPs also showed a strong inhibitory effect on proliferation of human umbilical vein endothelial cells in vitro and inhibited the tumor-induced angiogenesis in vivo by an alginate-encapsulated tumor cell assay. Further in vivo antitumor investigation, carried out in a C26 subcutaneous tumor model by intravenous injection, demonstrated that D-NPs could achieve a significant antitumor activity with sharply reduced microvessel density and significantly promoted tumor cell apoptosis. Additionally, the in vitro hemolysis analysis and in vivo serological and biochemical analysis revealed that D-NPs had no obvious toxicity. All the data indicated that the novel CPPC nanoparticles were ideal vectors for the systemic delivery of PEDF gene and might be widely

  10. Stress concentration factors for integral and pad reinforced nozzles in spherical pressure vessels subjected to radial load and moment

    International Nuclear Information System (INIS)

    Soliman, S.F.; Gill, S.S.

    1979-01-01

    Charts are presented giving the elastic stress concentration factors in spherical pressure vessels with pad and integral reinforcement for radial branches subjected to radial load and moment. The effect of all the geometrical parameters is discussed, including the limitations of thin shell theory on the validity of the results. (author)

  11. Reliability Analysis of Offshore Jacket Structures with Wave Load on Deck using the Model Correction Factor Method

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Friis-Hansen, P.; Nielsen, J.S.

    2006-01-01

    failure/collapse of jacket type platforms with wave in deck loads using the so-called Model Correction Factor Method (MCFM). A simple representative model for the RSR measure is developed and used in the MCFM technique. A realistic example is evaluated and it is seen that it is possible to perform...

  12. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect

    Directory of Open Access Journals (Sweden)

    Lucia Montenegro

    2017-12-01

    Full Text Available Lipid nanocarriers show occlusive properties that may be related to their ability to improve skin hydration. The aim of this work was to evaluate the relationship between in vitro occlusion factor and in vivo skin hydration for three types of lipid nanocarriers: nanoemulsions (NEs, solid lipid nanoparticles (SLNs and nanostructured lipid carriers (NLCs. These lipid nanocarriers were loaded with trans-resveratrol (RSV and incorporated in gel vehicles. In vitro occlusion factor was in the order SLNs > NLCs > NEs. Gels containing unloaded or RSV loaded lipid nanocarriers were applied on the back of a hand of 12 healthy volunteers twice a day for one week, recording skin hydration changes using the instrument Soft Plus. An increase of skin hydration was observed for all lipid nanocarriers (SLNs > NLCs > NEs. RSV loading into these nanocarriers did not affect in vitro and in vivo lipid nanocarriers effects. A linear relationship (r2 = 0.969 was observed between occlusion factor and in vivo increase of skin hydration. Therefore, the results of this study showed the feasibility of using the occlusion factor to predict in vivo skin hydration resulting from topical application of different lipid nanocarriers loading an active ingredient with no inherent hydrating activity.

  13. Session-RPE Method for Training Load Monitoring: Validity, Ecological Usefulness, and Influencing Factors

    Directory of Open Access Journals (Sweden)

    Monoem Haddad

    2017-11-01

    Full Text Available Purpose: The aim of this review is to (1 retrieve all data validating the Session-rating of perceived exertion (RPE-method using various criteria, (2 highlight the rationale of this method and its ecological usefulness, and (3 describe factors that can alter RPE and users of this method should take into consideration.Method: Search engines such as SPORTDiscus, PubMed, and Google Scholar databases in the English language between 2001 and 2016 were consulted for the validity and usefulness of the session-RPE method. Studies were considered for further analysis when they used the session-RPE method proposed by Foster et al. in 2001. Participants were athletes of any gender, age, or level of competition. Studies using languages other than English were excluded in the analysis of the validity and reliability of the session-RPE method. Other studies were examined to explain the rationale of the session-RPE method and the origin of RPE.Results: A total of 950 studies cited the Foster et al. study that proposed the session RPE-method. 36 studies have examined the validity and reliability of this proposed method using the modified CR-10.Conclusion: These studies confirmed the validity and good reliability and internal consistency of session-RPE method in several sports and physical activities with men and women of different age categories (children, adolescents, and adults among various expertise levels. This method could be used as “standing alone” method for training load (TL monitoring purposes though some recommend to combine it with other physiological parameters as heart rate.

  14. Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

    Science.gov (United States)

    Goldstein, Ido; Baek, Songjoon; Presman, Diego M.; Paakinaho, Ville; Swinstead, Erin E.; Hager, Gordon L.

    2017-01-01

    Fasting elicits transcriptional programs in hepatocytes leading to glucose and ketone production. This transcriptional program is regulated by many transcription factors (TFs). To understand how this complex network regulates the metabolic response to fasting, we aimed at isolating the enhancers and TFs dictating it. Measuring chromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous fasting-induced enhancers. By utilizing computational methods in combination with dissecting enhancer features and TF cistromes, we implicated four key TFs regulating the fasting response: glucocorticoid receptor (GR), cAMP responsive element binding protein 1 (CREB1), peroxisome proliferator activated receptor alpha (PPARA), and CCAAT/enhancer binding protein beta (CEBPB). These TFs regulate fuel production by two distinctly operating modules, each controlling a separate metabolic pathway. The gluconeogenic module operates through assisted loading, whereby GR doubles the number of sites occupied by CREB1 as well as enhances CREB1 binding intensity and increases accessibility of CREB1 binding sites. Importantly, this GR-assisted CREB1 binding was enhancer-selective and did not affect all CREB1-bound enhancers. Single-molecule tracking revealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 molecules. These events collectively result in rapid synergistic gene expression and higher hepatic glucose production. Conversely, the ketogenic module operates via a GR-induced TF cascade, whereby PPARA levels are increased following GR activation, facilitating gradual enhancer maturation next to PPARA target genes and delayed ketogenic gene expression. Our findings reveal a complex network of enhancers and TFs that dynamically cooperate to restore homeostasis upon fasting. PMID:28031249

  15. Application of Fracture Mechanics to Specify the Proof Load Factor for Clamp Band Systems of Launch Vehicles

    Science.gov (United States)

    Singaravelu, J.; Sundaresan, S.; Nageswara Rao, B.

    2013-04-01

    This article presents a methodology for evaluation of the proof load factor (PLF) for clamp band system (CBS) made of M250 Maraging steel following fracture mechanics principles.CBS is most widely used as a structural element and as a separation system. Using Taguchi's design of experiments and the response surface method (RSM) the compact tension specimens were tested to establish an empirical relation for the failure load ( P max) in terms of the ultimate strength, width, thickness, and initial crack length. The test results of P max closely matched with the developed RSM empirical relation. Crack growth rates of the maraging steel in different environments were examined. Fracture strength (σf) of center surface cracks and through-crack tension specimens are evaluated utilizing the fracture toughness ( K IC). Stress induced in merman band at flight loading conditions is evaluated to estimate the higher load factor and PLF. Statistical safety factor and reliability assessments were made for the specified flaw sizes useful in the development of fracture control plan for CBS of launch vehicles.

  16. Determination of the usage factor of components after cyclic loading by means of high-resolution microstructural examination

    International Nuclear Information System (INIS)

    Seibold, A.; Scheibe, A.; Assmann, H.D.

    1991-01-01

    Materials subjected to cyclic loading experience a change in the microstructure which may affect the service life. Quantification of the microstructural changes and allocation of the microstructural condition to the corresponding point on the fatigue curve for the component material allows the usage factor to be derived. Taking the low-alloy, fine-grained structural steel 20MnMoNi55 (quenched and tempered structure) as an example, the relationship between microstructure and number of load cycles can be represented in the form of a reference curve. High-resolution examination allows the usage factor to be determined up to η=N/N f ≅0.5 under the given cyclic loading. Only a small specimen volume is required for examination using a transmission electron microscope. It can be taken from the component without affecting the required minimum wall thickness. The location of the specimen must, however, be stipulated, e.g. the location of highest loading according to calculations. When removing the specimen, care must be taken to ensure that the micro-structure is not affected. If these requirements are observed, high-resolution microstructural examination provides a method for checking the usage factor of a component. (orig.)

  17. Embedded data collector (EDC) phase II load and resistance factor design (LRFD) : [summary].

    Science.gov (United States)

    2015-07-01

    Piles that support bridge structures are designed for the specific site characteristics and loads : that the piles are expected to bear. In Florida, driven piles are monitored during installation : (dynamically tested) to assess resistance, com...

  18. Influence of load type on power factor and harmonic composition of three-phase rectifier current

    Science.gov (United States)

    Nikolayzin, N. V.; Vstavskaya, E. V.; Konstantinov, V. I.; Konstantinova, O. V.

    2018-05-01

    This article is devoted to research of the harmonic composition of the three-phase rectifier current consumed when it operates with different types of load. The results are compared with Standard requirements.

  19. Which environmental factors most strongly influence a street's appeal for bicycle transport among adults? A conjoint study using manipulated photographs.

    Science.gov (United States)

    Mertens, Lieze; Van Dyck, Delfien; Ghekiere, Ariane; De Bourdeaudhuij, Ilse; Deforche, Benedicte; Van de Weghe, Nico; Van Cauwenberg, Jelle

    2016-09-01

    Micro-environmental factors (specific features within a streetscape), instead of macro-environmental factors (urban planning features), are more feasible to modify in existing neighborhoods and thus more practical to target for environmental interventions. Because it is often not possible to change the whole micro-environment at once, the current study aims to determine which micro-environmental factors should get the priority to target in physical environmental interventions increasing bicycle transport. Additionally, interaction effects among micro-environmental factors on the street's appeal for bicycle transport will be determined. In total, 1950 middle-aged adults completed a web-based questionnaire consisting of a set of 12 randomly assigned choice tasks with manipulated photographs. Seven micro-environmental factors (type of cycle path, speed limit, speed bump, vegetation, evenness of the cycle path surface, general upkeep and traffic density) were manipulated in each photograph. Conjoint analysis was used to analyze the data. Providing streets with a cycle path separated from motorized traffic seems to be the best strategy to increase the street's appeal for adults' bicycle transport. If this adjustment is not practically feasible, micro-environmental factors related to safety (i.e. speed limit, traffic density) may be more effective in promoting bicycle transport than micro-environmental factors related to comfort (i.e. evenness of the cycle path surface) or aesthetic (i.e. vegetation, general upkeep). On the other hand, when a more separated cycle path is already provided, micro-environmental factors related to comfort or aesthetic appeared to become more prominent. Findings obtained from this research could provide advice to physical environmental interventions about which environmental factors should get priority to modify in different environmental situations. The study was approved by the Ethics Committee of the Ghent University Hospital. B

  20. Risk factors and long-term outcomes of pediatric liver transplant recipients with chronic high Epstein-Barr virus loads.

    Science.gov (United States)

    Kamei, Hideya; Ito, Yoshinori; Kawada, Junichi; Ogiso, Satoshi; Onishi, Yasuharu; Komagome, Masahiko; Kurata, Nobuhiko; Ogura, Yasuhiro

    2018-04-20

    Serial monitoring of Epstein-Barr virus (EBV) reveals that certain pediatric liver transplant (LT) recipients exhibit high EBV loads for long periods. We investigated the incidence and risk factors of chronic high EBV (CHEBV) loads (continuous EBV DNA >10 000 IU/mL of whole blood for ≥6 months) and long-term outcomes. This single center, retrospective observational study investigated pediatric LT recipients who survived ≥6 months. We quantitated EBV DNA weekly during hospitalization and subsequently every 4 or 6 weeks at the outpatient clinic. Tacrolimus was maintained at a low trough level (5000 IU/mL). Thirty-one of 77 LT recipients developed CHEBV. Univariate analysis revealed that age 35 minutes, graft-to-recipient weight ratio (GRWR) >2.7%, and preoperative EBV seronegativity were significantly associated with the development of CHEBV loads. Multivariate analysis identified significant associations of CHEBV with WIT >35 minutes, GRWR >2.7%, and preoperative seronegative. None of the recipients developed post-transplantation lymphoproliferative disorder. Survival rates of patients with and without CHEBV loads were not significantly different. A significant number of pediatric LT recipients developed CHEBV loads. Long WIT, high GRWR, and preoperative EBV seronegativity were significantly associated with the development of CHEBV loads. Although the long-term outcomes of patients with or without CHEBV loads were not significantly different, further studies of more subjects are warranted. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Evaluation of the Effect of Platelet-Released Growth Factor and Immediate Orthodontic Loading on the Removal Torque of Miniscrews.

    Science.gov (United States)

    Bayani, Shahin; Masoomi, Fatemeh; Aghaabbasi, Sharereh; Farsinejad, Alireza

    2016-01-01

    The purpose of this study was to evaluate the effect of platelet-released growth factor (PRGF) and immediate orthodontic forces on the removal torque of miniscrews. This study was conducted on three male dogs aged 6 to 8 months with a body weight of 17.6 to 18.4 kg. Sixty miniscrews were inserted in the posterior aspect of the femur. There were four groups, including loaded miniscrews with application of PRGF, unloaded miniscrews without application of PRGF, unloaded miniscrews with PRGF, and loaded miniscrews without PRGF. Twenty miniscrews were inserted in the femoral bone of one foot of each dog, including all the aforementioned subgroups. After 12 weeks, the miniscrews were removed by a removal torque tester device and measured in newton centimeters. The mean removal torque values in four groups of immediately loaded screws with PRGF, unloaded screws with PRGF, immediately loaded screws without PRGF, and unloaded screws without PRGF were 19.68, 21.74, 13.65, and 15.46 Ncm, respectively. It was shown that the mean removal torque value for the group with PRGF was significantly higher than that in the other groups (P = .0001). Although there was a tendency toward a decrease in removal torque value with immediate loading, it was not statistically significant (P = .21). According to the results of this study, applying PRGF with miniscrews increased their stability, but the delivery of immediate force on miniscrews had no effect on the miniscrews' stability.

  2. SU-C-304-07: Are Small Field Detector Correction Factors Strongly Dependent On Machine-Specific Characteristics?

    International Nuclear Information System (INIS)

    Mathew, D; Tanny, S; Parsai, E; Sperling, N

    2015-01-01

    Purpose: The current small field dosimetry formalism utilizes quality correction factors to compensate for the difference in detector response relative to dose deposited in water. The correction factors are defined on a machine-specific basis for each beam quality and detector combination. Some research has suggested that the correction factors may only be weakly dependent on machine-to-machine variations, allowing for determinations of class-specific correction factors for various accelerator models. This research examines the differences in small field correction factors for three detectors across two Varian Truebeam accelerators to determine the correction factor dependence on machine-specific characteristics. Methods: Output factors were measured on two Varian Truebeam accelerators for equivalently tuned 6 MV and 6 FFF beams. Measurements were obtained using a commercial plastic scintillation detector (PSD), two ion chambers, and a diode detector. Measurements were made at a depth of 10 cm with an SSD of 100 cm for jaw-defined field sizes ranging from 3×3 cm 2 to 0.6×0.6 cm 2 , normalized to values at 5×5cm 2 . Correction factors for each field on each machine were calculated as the ratio of the detector response to the PSD response. Percent change of correction factors for the chambers are presented relative to the primary machine. Results: The Exradin A26 demonstrates a difference of 9% for 6×6mm 2 fields in both the 6FFF and 6MV beams. The A16 chamber demonstrates a 5%, and 3% difference in 6FFF and 6MV fields at the same field size respectively. The Edge diode exhibits less than 1.5% difference across both evaluated energies. Field sizes larger than 1.4×1.4cm2 demonstrated less than 1% difference for all detectors. Conclusion: Preliminary results suggest that class-specific correction may not be appropriate for micro-ionization chamber. For diode systems, the correction factor was substantially similar and may be useful for class-specific reference

  3. SU-C-304-07: Are Small Field Detector Correction Factors Strongly Dependent On Machine-Specific Characteristics?

    Energy Technology Data Exchange (ETDEWEB)

    Mathew, D; Tanny, S; Parsai, E; Sperling, N [University of Toledo Medical Center, Toledo, OH (United States)

    2015-06-15

    Purpose: The current small field dosimetry formalism utilizes quality correction factors to compensate for the difference in detector response relative to dose deposited in water. The correction factors are defined on a machine-specific basis for each beam quality and detector combination. Some research has suggested that the correction factors may only be weakly dependent on machine-to-machine variations, allowing for determinations of class-specific correction factors for various accelerator models. This research examines the differences in small field correction factors for three detectors across two Varian Truebeam accelerators to determine the correction factor dependence on machine-specific characteristics. Methods: Output factors were measured on two Varian Truebeam accelerators for equivalently tuned 6 MV and 6 FFF beams. Measurements were obtained using a commercial plastic scintillation detector (PSD), two ion chambers, and a diode detector. Measurements were made at a depth of 10 cm with an SSD of 100 cm for jaw-defined field sizes ranging from 3×3 cm{sup 2} to 0.6×0.6 cm{sup 2}, normalized to values at 5×5cm{sup 2}. Correction factors for each field on each machine were calculated as the ratio of the detector response to the PSD response. Percent change of correction factors for the chambers are presented relative to the primary machine. Results: The Exradin A26 demonstrates a difference of 9% for 6×6mm{sup 2} fields in both the 6FFF and 6MV beams. The A16 chamber demonstrates a 5%, and 3% difference in 6FFF and 6MV fields at the same field size respectively. The Edge diode exhibits less than 1.5% difference across both evaluated energies. Field sizes larger than 1.4×1.4cm2 demonstrated less than 1% difference for all detectors. Conclusion: Preliminary results suggest that class-specific correction may not be appropriate for micro-ionization chamber. For diode systems, the correction factor was substantially similar and may be useful for class

  4. Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study

    DEFF Research Database (Denmark)

    Best, Lyle G; Ferrell, Robert E; Decroo, Susan

    2009-01-01

    control of MBL2 expression is complex and genetic background effects in specific populations are largely unknown. METHODS: The Strong Heart Study is a longitudinal, cohort study of cardiovascular disease among American Indians. A subset of individuals genotyped for the above mentioned case-control study...... in Caucasian and other populations, result in markedly reduced expression of functional protein. Prospective epidemiologic studies, including a nested, case-control study from the present population, have demonstrated the ability of MBL2 genotypes to predict complications of atherosclerosis,. The genetic...

  5. The crystallochemical factor of strong keeping of radiogenic 187Os in the structure of rhenium-bearing molybdenites

    International Nuclear Information System (INIS)

    Val'ter, A.A.; Pisanskij, A.I.; Podberezskaya, N.V.

    2007-01-01

    To understand the possible cause of the strong keeping of radiogenic Os in comparison with initial Re in the molybdenite structure, we compare the cation positions in MoS 2 , ReS 2 , and OsS 2 and the geometry of 'empty' octahedra of the molybdenite structure. The similarity of 'empty' octahedra of MoS 2 and the Os environment in OsS 2 is determined. So, one can assume that knock-on atoms of 187 Os can be fixed in 'empty' octahedra by recoiling or the later thermal action

  6. Hierarchy of factors exerting an impact on nutrient load of the Baltic Sea and sustainable management of its drainage basin.

    Science.gov (United States)

    Kiedrzyńska, Edyta; Jóźwik, Adam; Kiedrzyński, Marcin; Zalewski, Maciej

    2014-11-15

    The aim of the paper was to evaluate 23 catchment factors that determine total phosphorus and total nitrogen load to the Baltic Sea. Standard correlation analysis and clustering were used. Both phosphorus and nitrogen loads were found to be positively related to the number of pigs and the human population associated with wastewater treatment plants (WWTPs) per km(2), while the number of cattle and agricultural area were found to influence nitrogen rather than phosphorus load, and the area of forests is negatively related to loads of both nutrients. Clustering indicates an overall north-south pattern in the spatial co-occurrence of socio-ecological factors, with some exceptions discussed in the paper. Positive steps in the Baltic Sea region have already been taken, but much remains to be done. The development of coherent response policies to reduce eutrophication in the Baltic Sea should be based on a comprehensive knowledge base, an appropriate information strategy and learning alliance platform in each drainage river catchments. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Enhancement of skin wound healing with decellularized scaffolds loaded with hyaluronic acid and epidermal growth factor

    Energy Technology Data Exchange (ETDEWEB)

    Su, Zhongchun; Ma, Huan; Wu, Zhengzheng [Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Jinan University, Guangzhou 510632 (China); Zeng, Huilan [Department of Hematology, The First Affiliated Hospital, Jinan University, Guangzhou 510632 (China); Li, Zhizhong [Department of Bone, The First Affiliated Hospital, Jinan University, Guangzhou 510632 (China); Wang, Yuechun; Liu, Gexiu [Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632 (China); Xu, Bin; Lin, Yongliang; Zhang, Peng [Grandhope Biotech Co., Ltd., Building D, #408, Guangzhou International Business Incubator, Guangzhou Science Park, Guangzhou 510663, Guangdong (China); Wei, Xing, E-mail: wei70@hotmail.com [Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Key Lab for Genetic Medicine of Guangdong Province, Jinan University, Guangzhou 510632 (China)

    2014-11-01

    Current therapy for skin wound healing still relies on skin transplantation. Many studies were done to try to find out ways to replace skin transplantation, but there is still no effective alternative therapy. In this study, decellularized scaffolds were prepared from pig peritoneum by a series of physical and chemical treatments, and scaffolds loaded with hyaluronic acid (HA) and epidermal growth factor (EGF) were tested for their effect on wound healing. MTT assay showed that EGF increased NIH3T3 cell viability and confirmed that EGF used in this study was biologically active in vitro. Scanning electron microscope (SEM) showed that HA stably attached to scaffolds even after soaking in PBS for 48 h. ELISA assay showed that HA increased the adsorption of EGF to scaffolds and sustained the release of EGF from scaffolds. Animal study showed that the wounds covered with scaffolds containing HA and EGF recovered best among all 4 groups and had wound healing rates of 49.86%, 70.94% and 87.41% respectively for days 10, 15 and 20 post-surgery compared to scaffolds alone with wound healing rates of 29.26%, 42.80% and 70.14%. In addition, the wounds covered with scaffolds containing EGF alone were smaller than no EGF scaffolds on days 10, 15 and 20 post-surgery. Hematoxylin–Eosin (HE) staining confirmed these results by showing that on days 10, 15 and 20 post-surgery, the thicker epidermis and dermis layers were observed in the wounds covered with scaffolds containing HA and EGF than scaffolds alone. In addition, the thicker epidermis and dermis layers were also observed in the wounds covered with scaffolds containing EGF than scaffolds alone. Skin appendages were observed on day 20 only in the wound covered with scaffolds containing HA and EGF. These results demonstrate that the scaffolds containing HA and EGF can enhance wound healing. - Highlights: • HA can increase the adsorption of EGF to decellularized scaffolds. • HA can sustain the release of EGF from

  8. RECENT STRONG EARTHQUAKES IN CENTRAL ASIA: REGULAR TECTONOPHYSICAL FEATURES OF LOCATIONS IN THE STRUCTURE AND GEODYNAMICS OF THE LITHOSPHERE. PART 1. MAIN GEODYNAMIC FACTORS PREDETERMINING LOCATIONS OF STRONG EARTHQUAKES IN THE STRUCTURE OF THE LITHOSPHER

    Directory of Open Access Journals (Sweden)

    S. I. Sherman

    2015-01-01

    Full Text Available Studying locations of strong earthquakes (М≥8 in space and time in Central Asia has been among top prob-lems for many years and still remains challenging for international research teams. The authors propose a new ap-proach that requires changing the paradigm of earthquake focus – solid rock relations, while this paradigm is a basis for practically all known physical models of earthquake foci. This paper describes the first step towards developing a new concept of the seismic process, including generation of strong earthquakes, with reference to specific geodynamic features of the part of the study region wherein strong earthquakes were recorded in the past two centuries. Our analysis of the locations of М≥8 earthquakes shows that in the past two centuries such earthquakes took place in areas of the dynamic influence of large deep faults in the western regions of Central Asia. In the continental Asia, there is a clear submeridional structural boundary (95–105°E between the western and eastern regions, and this is a factor controlling localization of strong seismic events in the western regions. Obviously, the Indostan plate’s pressure from the south is an energy source for such events. The strong earthquakes are located in a relatively small part of the territory of Central Asia (i.e. the western regions, which is significantly different from its neighbouring areas at the north, east and west, as evidenced by its specific geodynamic parameters. (1 The crust is twice as thick in the western regions than in the eastern regions. (2 In the western regions, the block structures re-sulting from the crust destruction, which are mainly represented by lense-shaped forms elongated in the submeridio-nal direction, tend to dominate. (3 Active faults bordering large block structures are characterized by significant slip velocities that reach maximum values in the central part of the Tibetan plateau. Further northward, slip velocities decrease

  9. Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration

    Directory of Open Access Journals (Sweden)

    Yu T

    2016-02-01

    Full Text Available Ting Yu,1,* Bei Xu,1,* Lili He,2 Shan Xia,3 Yan Chen,1 Jun Zeng,1 Yongmei Liu,1 Shuangzhi Li,1 Xiaoyue Tan,4 Ke Ren,1 Shaohua Yao,1 Xiangrong Song1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, 2College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, 3Central Laboratory, Science Education Department, Chengdu Normal University, Chengdu, Sichuan, 4Department of Pathology/Collaborative Innovation Center of Biotherapy, Medical School of Nankai University, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: Anti-angiogenesis has been proposed as an effective therapeutic strategy for cancer treatment. Pigment epithelium-derived factor (PEDF is one of the most powerful endogenous anti-angiogenic reagents discovered to date and PEDF gene therapy has been recognized as a promising treatment option for various tumors. There is an urgent need to develop a safe and valid vector for its systemic delivery. Herein, a novel gene delivery system based on the newly synthesized copolymer COOH-PEG-PLGA-COOH (CPPC was developed in this study, which was probably capable of overcoming the disadvantages of viral vectors and cationic lipids/polymers-based nonviral carriers. PEDF gene loaded CPPC nanoparticles (D-NPs were fabricated by a modified double-emulsion water-in-oil-in-water (W/O/W solvent evaporation method. D-NPs with uniform spherical shape had relatively high drug loading (~1.6%, probably because the introduced carboxyl group in poly (D,L-lactide-co-glycolide terminal enhanced the interaction of copolymer with the PEDF gene complexes. An excellent in vitro antitumor effect was found in both C26 and A549 cells treated by D-NPs, in which PEDF levels were dramatically elevated due to the successful transfection of PEDF gene. D-NPs also showed a strong inhibitory effect on

  10. Is Personality Fixed? Personality Changes as Much as "Variable" Economic Factors and More Strongly Predicts Changes to Life Satisfaction

    Science.gov (United States)

    Boyce, Christopher J.; Wood, Alex M.; Powdthavee, Nattavudh

    2013-01-01

    Personality is the strongest and most consistent cross-sectional predictor of high subjective well-being. Less predictive economic factors, such as higher income or improved job status, are often the focus of applied subjective well-being research due to a perception that they can change whereas personality cannot. As such there has been limited…

  11. Blue light treatment of Pseudomonas aeruginosa: Strong bactericidal activity, synergism with antibiotics and inactivation of virulence factors.

    Science.gov (United States)

    Fila, Grzegorz; Kawiak, Anna; Grinholc, Mariusz Stanislaw

    2017-08-18

    Pseudomonas aeruginosa is among the most common pathogens responsible for both acute and chronic infections of high incidence and severity. Additionally, P. aeruginosa resistance to conventional antimicrobials has increased rapidly over the past decade. Therefore, it is crucial to explore new therapeutic options, particularly options that specifically target the pathogenic mechanisms of this microbe. The ability of a pathogenic bacterium to cause disease is dependent upon the production of agents termed 'virulence factors', and approaches to mitigate these agents have gained increasing attention as new antibacterial strategies. Although blue light irradiation is a promising alternative approach, only limited and preliminary studies have described its effect on virulence factors. The current study aimed to investigate the effects of lethal and sub-lethal doses of blue light treatment (BLT) on P. aeruginosa virulence factors. We analyzed the inhibitory effects of blue light irradiation on the production/activity of several virulence factors. Lethal BLT inhibited the activity of pyocyanin, staphylolysin, pseudolysin and other proteases, but sub-lethal BLT did not affect the production/expression of proteases, phospholipases, and flagella- or type IV pili-associated motility. Moreover, a eukaryotic cytotoxicity test confirmed the decreased toxicity of blue light-treated extracellular P. aeruginosa fractions. Finally, the increased antimicrobial susceptibility of P. aeruginosa treated with sequential doses of sub-lethal BLT was demonstrated with a checkerboard test. Thus, this work provides evidence-based proof of the susceptibility of drug-resistant P. aeruginosa to BLT-mediated killing, accompanied by virulence factor reduction, and describes the synergy between antibiotics and sub-lethal BLT.

  12. Load forecasting

    International Nuclear Information System (INIS)

    Mak, H.

    1995-01-01

    Slides used in a presentation at The Power of Change Conference in Vancouver, BC in April 1995 about the changing needs for load forecasting were presented. Technological innovations and population increase were said to be the prime driving forces behind the changing needs in load forecasting. Structural changes, market place changes, electricity supply planning changes, and changes in planning objectives were other factors discussed. It was concluded that load forecasting was a form of information gathering, that provided important market intelligence

  13. Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon

    DEFF Research Database (Denmark)

    Olesen, Jens L; Heinemeier, Katja M; Haddad, Fadia

    2006-01-01

    Insulin-like growth factor I (IGF-I) is known to exert an anabolic effect on tendon fibroblast production of collagen. IGF-I's regulation is complex and involves six different IGF binding proteins (IGFBPs). Of these, IGFBP-4 and -5 could potentially influence the effect of IGF-I in the tendon...... because they both are produced in fibroblast; however, the response of IGFBP-4 and -5 to mechanical loading and their role in IGF-I regulation in tendinous tissue are unknown. A splice variant of IGF-I, mechano-growth factor (MGF) is upregulated and known to be important for adaptation in loaded muscle....... However, it is not known whether MGF is expressed and upregulated in mechanically loaded tendon. This study examined the effect of mechanical load on tendon collagen mRNA in relation to changes in the IGF-I systems mRNA expression. Data were collected at 2, 4, 8 and 16 days after surgical removal...

  14. Edge loading in metal-on-metal hips: low clearance is a new risk factor.

    Science.gov (United States)

    Underwood, Richard J; Zografos, Angelos; Sayles, Ritchie S; Hart, Alister; Cann, Philippa

    2012-03-01

    The revision rate of large head metal-on-metal and resurfacing hips are significantly higher than conventional total hip replacements. The revision of these components has been linked to high wear caused by edge loading; which occurs when the head-cup contact patch extends over the cup rim. There are two current explanations for this; first, there is loss of entrainment of synovial fluid resulting in breakdown of the lubricating film and second, edge loading results in a large local increase in contact pressure and consequent film thickness reduction at the cup rim, which causes an increase in wear. This paper develops a method to calculate the distance between the joint reaction force vector and the cup rim--the contact patch centre to rim (CPCR) distance. However, the critical distance for the risk of edge loading is the distance from the contact patch edge to rim (CPER) distance. An analysis of explanted hip components, divided into edge worn and non-edge-worn components showed that there was no statistical difference in CPCR values, but the CPER value was significantly lower for edge worn hips. Low clearance hips, which have a more conformal contact, have a larger diameter contact patch and thus are more at risk of edge loading for similarly positioned hips.

  15. Instructional Benefits of Spoken Words: A Review of Cognitive Load Factors

    Science.gov (United States)

    Kalyuga, Slava

    2012-01-01

    Spoken words have always been an important component of traditional instruction. With the development of modern educational technology tools, spoken text more often replaces or supplements written or on-screen textual representations. However, there could be a cognitive load cost involved in this trend, as spoken words can have both benefits and…

  16. The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighbouring bases

    Czech Academy of Sciences Publication Activity Database

    Takiya, S.; Gaži, Michal; Mach, Václav

    2003-01-01

    Roč. 33, - (2003), s. 1145-1154 ISSN 0965-1748 R&D Projects: GA AV ČR KSK5052113; GA ČR GA301/96/0153; GA MŠk ME 176 Institutional research plan: CEZ:AV0Z5007907 Keywords : Drosophila * bombys * Galleria Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.358, year: 2003

  17. Factors affecting stream nutrient loads: A synthesis of regional SPARROW model results for the continental United States

    Science.gov (United States)

    Preston, Stephen D.; Alexander, Richard B.; Schwarz, Gregory E.; Crawford, Charles G.

    2011-01-01

    We compared the results of 12 recently calibrated regional SPARROW (SPAtially Referenced Regressions On Watershed attributes) models covering most of the continental United States to evaluate the consistency and regional differences in factors affecting stream nutrient loads. The models - 6 for total nitrogen and 6 for total phosphorus - all provide similar levels of prediction accuracy, but those for major river basins in the eastern half of the country were somewhat more accurate. The models simulate long-term mean annual stream nutrient loads as a function of a wide range of known sources and climatic (precipitation, temperature), landscape (e.g., soils, geology), and aquatic factors affecting nutrient fate and transport. The results confirm the dominant effects of urban and agricultural sources on stream nutrient loads nationally and regionally, but reveal considerable spatial variability in the specific types of sources that control water quality. These include regional differences in the relative importance of different types of urban (municipal and industrial point vs. diffuse urban runoff) and agriculture (crop cultivation vs. animal waste) sources, as well as the effects of atmospheric deposition, mining, and background (e.g., soil phosphorus) sources on stream nutrients. Overall, we found that the SPARROW model results provide a consistent set of information for identifying the major sources and environmental factors affecting nutrient fate and transport in United States watersheds at regional and subregional scales. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

  18. Modeling and Finite Element Analysis of Load-Carrying Performance of a Wind Turbine Considering the Influence of Assembly Factors

    Directory of Open Access Journals (Sweden)

    Jianmei Wang

    2017-03-01

    Full Text Available In this work, a wind turbine shrink disk is used as the research object to investigate load-carrying performance of a multi-layer interference fit, and the theoretical model and finite element model are constructed. According to those models, a MW-level turbine shrink disk is designed, and a test device is developed to apply torque to this turbine shrink disk by hydraulic jack. Then, the circumferential slip between the contact surfaces is monitored and the slip of all contact surfaces is zero. This conclusion verifies the reasonability of the proposed models. The effect of the key influencing factors, such as machining deviation, assembly clearance and propel stroke, were analyzed. The contact pressure and load torque of the mating surfaces were obtained by building typical models with different parameters using finite element analysis (FEA. The results show that the minimum assembly clearance and the machining deviation within the machining range have little influence on load-carrying performance of multi-layer interference fit, while having a greater influence on the maximum assembly clearance and the propel stroke. The results also show that the load-carrying performance of a multiple-layer interference fit can be ensured only if the key factors are set within a reasonable design range. To avoid the abnormal operation of equipment caused by insufficient load torque, the propel stroke during practical assembly should be at least 0.95 times the designed propel stroke, which is significant in guiding the design and assembly of the multi-layer interference fit.

  19. Environmental factors exert strong control over the climate-growth relationships of Picea abies in Central Europe

    Czech Academy of Sciences Publication Activity Database

    Altman, Jan; Fibich, Pavel; Šantrůčková, H.; Doležal, Jiří; Štěpánek, Petr; Kopáček, Jiří; Hůnová, I.; Oulehle, F.; Tumajer, J.; Cienciala, E.

    2017-01-01

    Roč. 609, 31 December 2017 (2017), s. 506-516 ISSN 0048-9697 R&D Projects: GA ČR(CZ) GA14-12262S; GA ČR(CZ) GA17-07378S Institutional support: RVO:67985939 ; RVO:67179843 ; RVO:60077344 Keywords : Tree rings * Air pollution * Climate change Subject RIV: EH - Ecology, Behaviour; EH - Ecology, Behaviour (UEK-B); EH - Ecology, Behaviour (BC-A) OBOR OECD: Ecology; Environmental sciences (social aspects to be 5.7) (BC-A); Ecology (UEK-B) Impact factor: 4.900, year: 2016

  20. Enhanced antidepressant-like effects of the macromolecule trefoil factor 3 by loading into negatively charged liposomes

    Directory of Open Access Journals (Sweden)

    Qin J

    2014-11-01

    Full Text Available Jing Qin,1 Xu Yang,1–3 Jia Mi,4 Jianxin Wang,1 Jia Hou,1,2 Teng Shen,1 Yongji Li,2 Bin Wang,4 Xuri Li,4 Weili Zhu5 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, 2Department of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, 3Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, 4Binzhou Medical University, Yantai, 5National Institute on Drug Dependence, Peking University, Beijing, People’s Republic of China Abstract: Immunocytes, mainly neutrophils and monocytes, exhibit an intrinsic homing property, enabling them to migrate to sites of injury and inflammation. They can thus act as Trojan horses carrying concealed drug cargoes while migrating across impermeable barriers to sites of disease, especially the blood–brain barrier (BBB. In this study, to target circulating phagocytic cells, we formulated negatively charged nanosize liposomes and loaded trefoil factor 3 (TFF3 into liposomes by the pH-gradient method. According to the optimized formulation (5:1.5 of lipid to cholesterol, 10:1 of lipid to drug, 10 mg/mL of lipid concentration, and 10 mmol/L of phosphate-buffered saline, 44.47% entrapment efficiency was obtained for TFF3 liposomes with 129.6 nm particle size and –36.6 mV zeta potential. Compared with neutrally charged liposomes, the negatively charged liposomes showed a strong binding capacity with monocytes and were effectively carried by monocytes to cross the BBB in vitro. Furthermore, enhanced antidepressant-like effects were found in the tail-suspension and forced-swim tests in mice, as measured by decreased immobility time, as well as increased swimming time and reduced immobility in rats. These results suggested that negatively charged liposomes could improve the behavioral responses of TFF3, and our study opens up a new way for the development of

  1. The stress and stress intensity factors computation by BEM and FEM combination for nozzle junction under pressure and thermal loads

    International Nuclear Information System (INIS)

    Du, Q.; Cen, Z.; Zhu, H.

    1989-01-01

    This paper reports linear elastic fracture analysis based upon the stress intensity factor evaluation successfully applied to safety assessments of cracked structures. The nozzle junction are usually subjected to high pressure and thermal loads simultaneously. In validity of linear elastic fracture analysis, K can be decomposed into K P (caused by mechanic loads) and K τ (caused by thermal loads). Under thermal transient loading, explicit analysis (say by the FEM or BEM) of K tracing an entire history respectively for a range of crack depth may be much more time consuming. The techniques of weight function provide efficient means for transforming the problem into the stress computation of the uncracked structure and generation of influence function (for the given structure and size of crack). In this paper, a combination of BE-FEM has been used for the analysis of the cracked nozzle structure by techniques of weight function. The influence functions are obtained by coupled BE-FEM and the uncracked structure stress are computed by finite element methods

  2. Determination of Actual Friction Factors in Metal Forming under Heavy Loaded Regimes Combining Experimental and Numerical Analysis

    Science.gov (United States)

    Camacho, Ana María; Veganzones, Mariano; Claver, Juan; Martín, Francisco; Sevilla, Lorenzo; Sebastián, Miguel Ángel

    2016-01-01

    Tribological conditions can change drastically during heavy loaded regimes as experienced in metal forming; this is especially critical when lubrication can only be applied at the early stage of the process because the homogeneous lubricant layer can break along the die-workpiece interface. In these cases, adopting a constant friction factor for the lubricant-surface pair may not be a valid assumption. This paper presents a procedure based on the use of dual friction factor maps to determine friction factors employed in heavy loaded regimes. A finite element (FE) simulation is used to obtain the friction factor map for the alloy UNS A96082. Experiments were conducted using four lubricants (aluminum anti-size, MoS2 grease, silicone oil, and copper paste) to determine the actual friction curves. The experimental procedure is based on the application of lubricant only at the beginning of the first stage of ring compression, and not at intermediate stages as is usual in typical ring compression tests (RCTs). The results show that for small reductions (rh 20%), it is recommended to obtain an average value of the friction factor for every lubricant-surface pair in the range of deformation considered. PMID:28773868

  3. Determination of Actual Friction Factors in Metal Forming under Heavy Loaded Regimes Combining Experimental and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Ana María Camacho

    2016-09-01

    Full Text Available Tribological conditions can change drastically during heavy loaded regimes as experienced in metal forming; this is especially critical when lubrication can only be applied at the early stage of the process because the homogeneous lubricant layer can break along the die-workpiece interface. In these cases, adopting a constant friction factor for the lubricant-surface pair may not be a valid assumption. This paper presents a procedure based on the use of dual friction factor maps to determine friction factors employed in heavy loaded regimes. A finite element (FE simulation is used to obtain the friction factor map for the alloy UNS A96082. Experiments were conducted using four lubricants (aluminum anti-size, MoS2 grease, silicone oil, and copper paste to determine the actual friction curves. The experimental procedure is based on the application of lubricant only at the beginning of the first stage of ring compression, and not at intermediate stages as is usual in typical ring compression tests (RCTs. The results show that for small reductions (rh < 20%, the conventional RCT can be applied because the tribological conditions remain similar. For large reductions (rh > 20%, it is recommended to obtain an average value of the friction factor for every lubricant-surface pair in the range of deformation considered.

  4. Performance study of K{sub e} factors in simplified elastic plastic fatigue analyses with emphasis on thermal cyclic loading

    Energy Technology Data Exchange (ETDEWEB)

    Lang, Hermann, E-mail: hermann.lang@areva.com [AREVA NP GmbH, PEEA-G, Henri-Dunant-Strasse 50, 91058 Erlangen (Germany); Rudolph, Juergen; Ziegler, Rainer [AREVA NP GmbH, PEEA-G, Henri-Dunant-Strasse 50, 91058 Erlangen (Germany)

    2011-08-15

    As code-based fully elastic plastic code conforming fatigue analyses are still time consuming, simplified elastic plastic analysis is often applied. This procedure is known to be overly conservative for some conditions due to the applied plastification (penalty) factor K{sub e}. As a consequence, less conservative fully elastic plastic fatigue analyses based on non-linear finite element analyses (FEA) or simplified elastic plastic analysis based on more realistic K{sub e} factors have to be used for fatigue design. The demand for more realistic K{sub e} factors is covered as a requirement of practical fatigue analysis. Different code-based K{sub e} procedures are reviewed in this paper with special regard to performance under thermal cyclic loading conditions. Other approximation formulae such as those by Neuber, Seeger/Beste or Kuehnapfel are not evaluated in this context because of their applicability to mechanical loading excluding thermal cyclic loading conditions typical for power plant operation. Besides the current code-based K{sub e} corrections, the ASME Code Case N-779 (e.g. Adam's proposal) and its modification in ASME Section VIII is considered. Comparison of elastic plastic results and results from the Rules for Nuclear Facility Components and Rules for Pressure Vessels reveals a considerable overestimation of usage factor in the case of ASME III and KTA 3201.2 for the examined examples. Usage factors according to RCC-M, Adams (ASME Code Case N-779), ASME VIII (alternative) and EN 13445-3 are essentially comparable and less conservative for these examples. The K{sub v} correction as well as the applied yield criterion (Tresca or von Mises) essentially influence the quality of the more advanced plasticity corrections (e.g. ASME Code Case N-779 and RCC-M). Hence, new proposals are based on a refined K{sub v} correction.

  5. Performance study of Ke factors in simplified elastic plastic fatigue analyses with emphasis on thermal cyclic loading

    International Nuclear Information System (INIS)

    Lang, Hermann; Rudolph, Juergen; Ziegler, Rainer

    2011-01-01

    As code-based fully elastic plastic code conforming fatigue analyses are still time consuming, simplified elastic plastic analysis is often applied. This procedure is known to be overly conservative for some conditions due to the applied plastification (penalty) factor K e . As a consequence, less conservative fully elastic plastic fatigue analyses based on non-linear finite element analyses (FEA) or simplified elastic plastic analysis based on more realistic K e factors have to be used for fatigue design. The demand for more realistic K e factors is covered as a requirement of practical fatigue analysis. Different code-based K e procedures are reviewed in this paper with special regard to performance under thermal cyclic loading conditions. Other approximation formulae such as those by Neuber, Seeger/Beste or Kuehnapfel are not evaluated in this context because of their applicability to mechanical loading excluding thermal cyclic loading conditions typical for power plant operation. Besides the current code-based K e corrections, the ASME Code Case N-779 (e.g. Adam's proposal) and its modification in ASME Section VIII is considered. Comparison of elastic plastic results and results from the Rules for Nuclear Facility Components and Rules for Pressure Vessels reveals a considerable overestimation of usage factor in the case of ASME III and KTA 3201.2 for the examined examples. Usage factors according to RCC-M, Adams (ASME Code Case N-779), ASME VIII (alternative) and EN 13445-3 are essentially comparable and less conservative for these examples. The K v correction as well as the applied yield criterion (Tresca or von Mises) essentially influence the quality of the more advanced plasticity corrections (e.g. ASME Code Case N-779 and RCC-M). Hence, new proposals are based on a refined K v correction.

  6. Effect of Loads and Other Key Factors on Oil-Transformer Ageing: Sustainability Benefits and Challenges

    OpenAIRE

    Radu Godina; Eduardo M. G. Rodrigues; João C. O. Matias; João P. S. Catalão

    2015-01-01

    Transformers are one of the more expensive pieces of equipment found in a distribution network. The transformer’s role has not changed over the last decades. With simple construction and at the same time mechanically robust, they offer long term service that on average can reach half a century. Today, with the ongoing trend to supply a growing number of non-linear loads along with the notion of distributed generation (DG), a new challenge has arisen in terms of transformer sustainability, ...

  7. Stress Intensity Factors for Cracked Metallic Structures Under Rapid Thermal Loading

    Science.gov (United States)

    1987-10-01

    solution algorithm was developed based on the influence function method, and numerical results were generated to show the variation of K with flaw size and...numerical algorithms developed can be executed on a desktop microcomputer illustrating the efficient and powerful characteristic of the influence function method... Function Method 3-6 Superposition and Crack Face Loading Equivalence 3-7 Influence Function Generation 3-10 Influence Functions For Two Cracked Body

  8. <strong>Mini-project>

    DEFF Research Database (Denmark)

    Katajainen, Jyrki

    2008-01-01

    In this project the goal is to develop the safe * family of containers for the CPH STL. The containers to be developed should be safer and more reliable than any of the existing implementations. A special focus should be put on strong exception safety since none of the existing prototypes available...

  9. Factors controlling stream water nitrate and phosphor loads during precipitation events

    Science.gov (United States)

    Rozemeijer, J.; van der Velde, Y.; van Geer, F.; de Rooij, G. H.; Broers, H.; Bierkens, M. F.

    2009-12-01

    Pollution of surface waters in densely populated areas with intensive land use is a serious threat to their ecological, industrial and recreational utilization. European and national manure policies and several regional and local pilot projects aim at reducing pollution loads to surface waters. For the evaluation of measures, water authorities and environmental research institutes are putting a lot of effort into monitoring surface water quality. Within regional surface water quality monitoring networks, the measurement locations are usually situated in the downstream part of the catchment to represent a larger area. The monitoring frequency is usually low (e.g. monthly), due to the high costs for sampling and analysis. As a consequence, human induced trends in nutrient loads and concentrations in these monitoring data are often concealed by the large variability of surface water quality caused by meteorological variations. Because this natural variability in surface water quality is poorly understood, large uncertainties occur in the estimates of (trends in) nutrient loads or average concentrations. This study aims at uncertainty reduction in the estimates of mean concentrations and loads of N and P from regional monitoring data. For this purpose, we related continuous records of stream water N and P concentrations to easier and cheaper to collect quantitative data on precipitation, discharge, groundwater level and tube drain discharge. A specially designed multi scale experimental setup was installed in an agricultural lowland catchment in The Netherlands. At the catchment outlet, continuous measurements of water quality and discharge were performed from July 2007-January 2009. At an experimental field within the catchment we collected continuous measurements of precipitation, groundwater levels and tube drain discharges. 20 significant rainfall events with a variety of antecedent conditions, durations and intensities were selected for analysis. Singular and

  10. Analysis of the Contribution of Wind Drift Factor to Oil Slick Movement under Strong Tidal Condition: Hebei Spirit Oil Spill Case

    OpenAIRE

    Kim, Tae-Ho; Yang, Chan-Su; Oh, Jeong-Hwan; Ouchi, Kazuo

    2014-01-01

    The purpose of this study is to investigate the effects of the wind drift factor under strong tidal conditions in the western coastal area of Korea on the movement of oil slicks caused by the Hebei Spirit oil spill accident in 2007. The movement of oil slicks was computed using a simple simulation model based on the empirical formula as a function of surface current, wind speed, and the wind drift factor. For the simulation, the Environmental Fluid Dynamics Code (EFDC) model and Automatic Wea...

  11. Flexibility factors for small (d/D<1/3) branch connections with external loadings

    International Nuclear Information System (INIS)

    Rodabaugh, E.C.; Moore, S.E.

    1977-03-01

    A piping system analysis is accurate only to the extent that the flexibilities of all portions of the piping system are accurately known. The use of a ''conservative'' flexibility factor is not possible because such a factor cannot be defined. Branch connections require a definition of flexibility factor which is conceptually different than commonly used for curved pipe. An appropriate definition for the flexibility factors of branch connections is presented. The background of the present Code formulations of flexibility factors for branch connections is discussed. Additional theoretical data and test data are summarized. Recommendations are given for revisions to Code formulations for handling the flexibility of branch connections in a piping system analysis

  12. Strong interactions

    International Nuclear Information System (INIS)

    Froissart, Marcel

    1976-01-01

    Strong interactions are introduced by their more obvious aspect: nuclear forces. In hadron family, the nucleon octet, OMEGA - decuplet, and quark triply are successively considered. Pion wave having been put at the origin of nuclear forces, low energy phenomena are described, the force being explained as an exchange of structure corresponding to a Regge trajectory in a variable rotating state instead of the exchange of a well defined particle. At high energies the concepts of pomeron, parton and stratons are introduced, pionization and fragmentation are briefly differentiated [fr

  13. Refined shear correction factor for very thick simply supported and uniformly loaded isosceles right triangular auxetic plates

    International Nuclear Information System (INIS)

    Lim, Teik-Cheng

    2016-01-01

    For moderately thick plates, the use of First order Shear Deformation Theory (FSDT) with a constant shear correction factor of 5/6 is sufficient to take into account the plate deflection arising from transverse shear deformation. For very thick plates, the use of Third order Shear Deformation Theory (TSDT) is preferred as it allows the shear strain distribution to be varied through the plate thickness. Therefore no correction factor is required in TSDT, unlike FSDT. Due to the complexity involved in TSDT, this paper obtains a more accurate shear correction factor for use in FSDT of very thick simply supported and uniformly loaded isosceles right triangular plates based on the TSDT. By matching the maximum deflections for this plate according to FSDT and TSDT, a variable shear correction factor is obtained. Results show that the shear correction factor for the simplified TSDT, i.e. 14/17, is least accurate. The commonly adopted shear correction factor of 5/6 in FSDT is valid only for very thin or highly auxetic plates. This paper provides a variable shear correction for FSDT deflection that matches the plate deflection by TSDT. This variable shear correction factor allows designers to justify the use of a commonly adopted shear correction factor of 5/6 even for very thick plates as long as the Poisson’s ratio of the plate material is sufficiently negative. (paper)

  14. Family load estimates and risk factors of anxiety disorders in a nationwide three generation study

    DEFF Research Database (Denmark)

    Helenius, Dorte; Munk-Jørgensen, Povl; Steinhausen, Hans-Christoph

    2014-01-01

    region. Psychiatric diagnoses were also obtained for parents, siblings, and offspring. A family load component was obtained by using various mixed regression models. Anxiety disorders occurred significantly more often in case than in control families. Having a mother, father, or a sibling......The present study investigated how often anxiety disorders with different ages of onset occurred in affected families compared to control families. Furthermore, the study addressed the impact of sex, region of residence, year and month of birth, and parental age at birth. The sample included N=1373......, provide further and solid evidence for the family aggregation of anxiety disorders....

  15. Stress-intensity factor equations for cracks in three-dimensional finite bodies subjected to tension and bending loads

    Science.gov (United States)

    Newman, J. C., Jr.; Raju, I. S.

    1984-01-01

    Stress intensity factor equations are presented for an embedded elliptical crack, a semielliptical surface crack, a quarter elliptical corner crack, a semielliptical surface crack along the bore of a circular hole, and a quarter elliptical corner crack at the edge of a circular hole in finite plates. The plates were subjected to either remote tension or bending loads. The stress intensity factors used to develop these equations were obtained from previous three dimensional finite element analyses of these crack configurations. The equations give stress intensity factors as a function of parametric angle, crack depth, crack length, plate thickness, and, where applicable, hole radius. The ratio of crack depth to plate thickness ranged from 0 to 1, the ratio of crack depth to crack length ranged from 0.2 to 2, and the ratio of hole radius to plate thickness ranged from 0.5 to 2. The effects of plate width on stress intensity variation along the crack front were also included.

  16. Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

    International Nuclear Information System (INIS)

    Ribeiro, M.P.; Morgado, P.I.; Miguel, S.P.; Coutinho, P.; Correia, I.J.

    2013-01-01

    Skin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and histological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine. - Highlights: • Evaluation of a hydrogel loaded with microparticles containing growth factors for wound healing • In vitro and in vivo assays were performed to characterize the properties of the skin substitute. • The monitoring of the wound healing process was done by macroscopic and histological analysis

  17. Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, M.P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda (Portugal); Morgado, P.I.; Miguel, S.P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); Coutinho, P. [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal); UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda (Portugal); Correia, I.J., E-mail: icorreia@ubi.pt [CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã (Portugal)

    2013-07-01

    Skin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and histological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine. - Highlights: • Evaluation of a hydrogel loaded with microparticles containing growth factors for wound healing • In vitro and in vivo assays were performed to characterize the properties of the skin substitute. • The monitoring of the wound healing process was done by macroscopic and histological analysis.

  18. Dependence of twinned volume fraction on loading mode and Schmid factor in randomly textured magnesium

    Czech Academy of Sciences Publication Activity Database

    Čapek, Jan; Máthis, K.; Clausen, B.; Barnett, M.R.

    2017-01-01

    Roč. 130, MAY (2017), s. 319-328 ISSN 1359-6454 R&D Projects: GA ČR GB14-36566G Institutional support: RVO:61389005 Keywords : twinning * magnesium * neutron diffraction * Schmid factor Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 5.301, year: 2016

  19. How we eat what we eat: identifying meal routines and practices most strongly associated with healthy and unhealthy dietary factors among young adults.

    Science.gov (United States)

    Laska, Melissa N; Hearst, Mary O; Lust, Katherine; Lytle, Leslie A; Story, Mary

    2015-08-01

    (i) To examine associations between young adults' meal routines and practices (e.g. food preparation, meal skipping, eating on the run) and key dietary indicators (fruit/vegetable, fast-food and sugar-sweetened beverage intakes) and (ii) to develop indices of protective and risky meal practices most strongly associated with diet. Cross-sectional survey. Minneapolis/St. Paul metropolitan area, Minnesota (USA). A diverse sample of community college and public university students (n 1013). Meal routines and practices most strongly associated with healthy dietary patterns were related to home food preparation (i.e. preparing meals at home, preparing meals with vegetables) and meal regularity (i.e. routine consumption of evening meals and breakfast). In contrast, factors most strongly associated with poor dietary patterns included eating on the run, using media while eating and purchasing foods/beverages on campus. A Protective Factors Index, summing selected protective meal routines and practices, was positively associated with fruit/vegetable consumption and negatively associated with fast-food and sugar-sweetened beverage consumption (PMeal routines and practices were significantly associated with young adults' dietary patterns, suggesting that ways in which individuals structure mealtimes and contextual characteristics of eating likely influence food choice. Thus, in addition to considering specific food choices, it also may be important to consider the context of mealtimes in developing dietary messaging and guidelines.

  20. Monitoring organic loading to swimming pools by fluorescence excitation–emission matrix with parallel factor analysis (PARAFAC)

    DEFF Research Database (Denmark)

    Seredynska-Sobecka, Bozena; Stedmon, Colin; Boe-Hansen, Rasmus

    2011-01-01

    Fluorescence Excitation–Emission Matrix spectroscopy combined with parallel factor analysis was employed to monitor water quality and organic contamination in swimming pools. The fluorescence signal of the swimming pool organic matter was low but increased slightly through the day. The analysis...... revealed that the organic matter fluorescence was characterised by five different components, one of which was unique to swimming pool organic matter and one which was specific to organic contamination. The latter component had emission peaks at 420nm and was found to be a sensitive indicator of organic...... loading in swimming pool water. The fluorescence at 420nm gradually increased during opening hours and represented material accumulating through the day....

  1. Does vertical integration have an effect on load factor? - A test on coal-fired plants in England and Wales

    International Nuclear Information System (INIS)

    Lopez, Jose A.; Salies, Evens

    2006-02-01

    Today in the British electricity industry, most electricity suppliers hedge a large proportion of their residential customer base requirements by owning their own plant. The non-storability of electricity and the corresponding need for an instantaneous matching of generation and consumption creates a business need for integration. From a sample of half-hour data on load factor for coal-fired power plants in England and Wales, this paper tests the hypothesis that vertical integration with retail businesses affects the extent to which producers utilize their capacity. We also pay attention to this potential effect during periods of peak demand. (authors)

  2. Demand characteristics and load factor in a sugar cane brandy distillery; Caracteristica de demanda e fator de carga numa destilaria de aguardente

    Energy Technology Data Exchange (ETDEWEB)

    Assumpcao, C R [UNESP, Ilha Solteira, SP (Brazil). Faculdade de Engenharia; Souza, L L.G. [UNESP, Botucatu, SP (Brazil). Faculdade de Ciencias Agronomicas

    1987-12-31

    The actual and calculated load factor values were also confronted for both harvests studied, looking for a polynomial equation that could represent the relationships among the variables. (author) 11 refs., 4 figs., 3 tabs.

  3. The prediction of the impact of climatic factors on short-term electric power load based on the big data of smart city

    Science.gov (United States)

    Qiu, Yunfei; Li, Xizhong; Zheng, Wei; Hu, Qinghe; Wei, Zhanmeng; Yue, Yaqin

    2017-08-01

    The climate changes have great impact on the residents’ electricity consumption, so the study on the impact of climatic factors on electric power load is of significance. In this paper, the effects of the data of temperature, rainfall and wind of smart city on short-term power load is studied to predict power load. The authors studied the relation between power load and daily temperature, rainfall and wind in the 31 days of January of one year. In the research, the authors used the Matlab neural network toolbox to establish the combinational forecasting model. The authors trained the original input data continuously to get the internal rules inside the data and used the rules to predict the daily power load in the next January. The prediction method relies on the accuracy of weather forecasting. If the weather forecasting is different from the actual weather, we need to correct the climatic factors to ensure accurate prediction.

  4. Analysis of the strong coupling form factors of ΣbNB and ΣcND in QCD sum rules

    Science.gov (United States)

    Yu, Guo-Liang; Wang, Zhi-Gang; Li, Zhen-Yu

    2017-08-01

    In this article, we study the strong interaction of the vertices Σ b NB and Σ c ND using the three-point QCD sum rules under two different Dirac structures. Considering the contributions of the vacuum condensates up to dimension 5 in the operation product expansion, the form factors of these vertices are calculated. Then, we fit the form factors into analytical functions and extrapolate them into time-like regions, which gives the coupling constants. Our analysis indicates that the coupling constants for these two vertices are G ΣbNB = 0.43±0.01 GeV-1 and G ΣcND = 3.76±0.05 GeV-1. Supported by Fundamental Research Funds for the Central Universities (2016MS133)

  5. Uniqueness conditions for constrained three-way factor decompositions with linearly dependent loadings

    NARCIS (Netherlands)

    Stegeman, Alwin; De Almeida, Andre L. F.

    2009-01-01

    In this paper, we derive uniqueness conditions for a constrained version of the parallel factor (Parafac) decomposition, also known as canonical decomposition (Candecomp). Candecomp/Parafac (CP) decomposes a three-way array into a prespecified number of outer product arrays. The constraint is that

  6. Comparison of Acceleration and Impact Stress as Possible Loading Factors in Phonation: A Computer Modeling Study

    Czech Academy of Sciences Publication Activity Database

    Horáček, Jaromír; Laukkanen, A. M.; Šidlof, Petr; Murphy, P.; Švec, J. G.

    2009-01-01

    Roč. 61, č. 3 (2009), s. 137-145 ISSN 1021-7762 R&D Projects: GA ČR(CZ) GA101/08/1155 Institutional research plan: CEZ:AV0Z20760514 Keywords : biomechanics of voice modeling * fundamental frequency * phoniation type * gender differences in voice Subject RIV: BI - Acoustics Impact factor: 1.439, year: 2007

  7. Using a latent variable model with non-constant factor loadings to examine PM2.5 constituents related to secondary inorganic aerosols.

    Science.gov (United States)

    Zhang, Zhenzhen; O'Neill, Marie S; Sánchez, Brisa N

    2016-04-01

    Factor analysis is a commonly used method of modelling correlated multivariate exposure data. Typically, the measurement model is assumed to have constant factor loadings. However, from our preliminary analyses of the Environmental Protection Agency's (EPA's) PM 2.5 fine speciation data, we have observed that the factor loadings for four constituents change considerably in stratified analyses. Since invariance of factor loadings is a prerequisite for valid comparison of the underlying latent variables, we propose a factor model that includes non-constant factor loadings that change over time and space using P-spline penalized with the generalized cross-validation (GCV) criterion. The model is implemented using the Expectation-Maximization (EM) algorithm and we select the multiple spline smoothing parameters by minimizing the GCV criterion with Newton's method during each iteration of the EM algorithm. The algorithm is applied to a one-factor model that includes four constituents. Through bootstrap confidence bands, we find that the factor loading for total nitrate changes across seasons and geographic regions.

  8. Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study

    Directory of Open Access Journals (Sweden)

    Zahra Bahadoran

    2015-06-01

    Full Text Available BackgroundIn this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL and protein to potassium (Pro:K ratio, with cardiometabolic risk factors in Tehranian adults.MethodsA cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011 on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C, serum creatinine, and fasting blood glucose.ResultsThe mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001, waist circumference (β=0.062, P<0.01, serum triglycerides (β=0.143, P<0.01, HDL-C (β=-0.11, P<0.01, diastolic blood pressure (β=0.062, P<0.01, and serum creatinine (β=0.142, P<0.001. Pro:K ratio was associated with weight (β=0.055, P<0.001, waist circumference (β=0.04, P<0.01, serum HDL-C (β=-0.06, P<0.01, serum triglycerides (β=0.03, P<0.05, diastolic blood pressure (β=0.026, P<0.05, and serum creatinine (β=0.07, P<0.01.ConclusionA more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

  9. Factors Controlling Nitrogen Loadings in Major River Basins Across the United States

    Science.gov (United States)

    Boyer, E. W.; Alexander, R. B.; Galloway, J. N.; Golden, H. E.; Moore, R. B.; Schwarz, G. E.; Harvey, J. W.; Gomez-Velez, J. D.; Scott, D.; Clune, J.

    2017-12-01

    Inputs of reactive nitrogen (all N species except for N2) have been increasing worldwide, largely due to human activities associated with food production and energy consumption via the combustion of fossil fuels and biofuels. Despite the obvious essential benefits of a plentiful supply of food and energy, the adverse consequences associated with the accumulation of N in the environment are large. Most of the N created by human activities is released to the environment, often with unintended negative consequences. The greater the inputs of N to the landscape, the greater the potential for negative effects - caused by greenhouse gas production, ground level ozone, acid deposition, and N overload; which in turn can contribute to climate change, degradation of soils and vegetation, acidification of surface waters, coastal eutrophication, hypoxia, habitat loss, and loss of stratospheric ozone. Here we present a contemporary inventory of reactive N inputs to major water regions in the United States, and discuss accounting methods for quantifying N sources and transport. Furthermore, we quantify loadings of N from terrestrial headwaters downstream to coastal estuaries and embayments. N delivery to downstream waters is influenced by nutrient sources as well as coupled hydrological and biogeochemical processes occurring along the river corridor (e.g., travel time distributions, denitrification, and storage) that scale with stream size and are affected by impoundments such as lakes and reservoirs. This underscores the need to account for the nonlinear interactions of aquatic transport processes with watershed nutrient sources, as well as cumulative effects, in developing efficient nutrient reduction strategies. Our work is useful as a benchmark of the current N situation against which future progress can be assessed in varying water regions of the country; amidst changing N inputs, policies, and management strategies. Our results stem from the EPA Integrated Nitrogen

  10. A-FABP Concentration Is More Strongly Associated with Cardiometabolic Risk Factors and the Occurrence of Metabolic Syndrome in Premenopausal Than in Postmenopausal Middle-Aged Women

    Directory of Open Access Journals (Sweden)

    Anna Stefanska

    2014-01-01

    Full Text Available We aimed at the evaluation of the relationship between adipocyte fatty acid binding protein (A-FABP and cardiometabolic risk factors in premenopausal and postmenopausal women. Additionally, we compared A-FABP with adipokines related to metabolic syndrome (MetS such as leptin and adiponectin. 94 premenopausal and 90 early postmenopausal middle-aged Caucasian women were subject to examinations. Postmenopausal women had higher A-FABP than premenopausal; this difference became insignificant after controlling for age. We found significantly higher correlation coefficients between A-FABP and TC/HDL-C ratio and number of MetS components in premenopausal women, compared to postmenopausal. Each 1 ng/dL increase in A-FABP concentration significantly increased the probability of occurrence of atherogenic lipid profile in premenopausal women, even after multivariate adjustment. All odds ratios became insignificant after controlling for BMI in postmenopausal women. A-FABP was more strongly associated with MetS than leptin and adiponectin in premenopausal women. Adiponectin concentration was a better biomarker for MetS after menopause. Our results suggest that the A-FABP is more strongly associated with some cardiometabolic risk factors in premenopausal than in postmenopausal women. Higher values of A-FABP after menopause are mainly explained by the fact that postmenopausal women are older. Because of the limitation of study, these results should be interpreted with caution.

  11. Analysis of the Contribution of Wind Drift Factor to Oil Slick Movement under Strong Tidal Condition: Hebei Spirit Oil Spill Case

    Science.gov (United States)

    Kim, Tae-Ho; Yang, Chan-Su; Oh, Jeong-Hwan; Ouchi, Kazuo

    2014-01-01

    The purpose of this study is to investigate the effects of the wind drift factor under strong tidal conditions in the western coastal area of Korea on the movement of oil slicks caused by the Hebei Spirit oil spill accident in 2007. The movement of oil slicks was computed using a simple simulation model based on the empirical formula as a function of surface current, wind speed, and the wind drift factor. For the simulation, the Environmental Fluid Dynamics Code (EFDC) model and Automatic Weather System (AWS) were used to generate tidal and wind fields respectively. Simulation results were then compared with 5 sets of spaceborne optical and synthetic aperture radar (SAR) data. From the present study, it was found that highest matching rate between the simulation results and satellite imagery was obtained with different values of the wind drift factor, and to first order, this factor was linearly proportional to the wind speed. Based on the results, a new modified empirical formula was proposed for forecasting the movement of oil slicks on the coastal area. PMID:24498094

  12. Analysis of the contribution of wind drift factor to oil slick movement under strong tidal condition: Hebei Spirit oil spill case.

    Directory of Open Access Journals (Sweden)

    Tae-Ho Kim

    Full Text Available The purpose of this study is to investigate the effects of the wind drift factor under strong tidal conditions in the western coastal area of Korea on the movement of oil slicks caused by the Hebei Spirit oil spill accident in 2007. The movement of oil slicks was computed using a simple simulation model based on the empirical formula as a function of surface current, wind speed, and the wind drift factor. For the simulation, the Environmental Fluid Dynamics Code (EFDC model and Automatic Weather System (AWS were used to generate tidal and wind fields respectively. Simulation results were then compared with 5 sets of spaceborne optical and synthetic aperture radar (SAR data. From the present study, it was found that highest matching rate between the simulation results and satellite imagery was obtained with different values of the wind drift factor, and to first order, this factor was linearly proportional to the wind speed. Based on the results, a new modified empirical formula was proposed for forecasting the movement of oil slicks on the coastal area.

  13. One-pot synthesis of strongly fluorescent DNA-CuInS2 quantum dots for label-free and ultrasensitive detection of anthrax lethal factor DNA

    International Nuclear Information System (INIS)

    Liu, Ziping; Su, Xingguang

    2016-01-01

    Herein, high quality DNA-CuInS 2 QDs are facilely synthesized through a one-pot hydrothermal method with fluorescence quantum yield as high as 23.4%, and the strongly fluorescent DNA-CuInS 2 QDs have been utilized as a novel fluorescent biosensor for label-free and ultrasensitive detection of anthrax lethal factor DNA. L-Cysteine (L-Cys) and a specific-sequence DNA are used as co-ligands to stabilize the CuInS 2 QDs. The specific-sequence DNA consists of two domains: phosphorothiolates domain (sulfur-containing variants of the usual phosphodiester backbone) controls the nanocrystal passivation and serves as a ligand, and the functional domain (non-phosphorothioates) controls the biorecognition. The as-prepared DNA-CuInS 2 QDs have high stability, good water-solubility and low toxicity. Under the optimized conditions, a linear correlation was established between the fluorescence intensity ratio I/I 0 (I 0 is the original fluorescence intensity of DNA-CuInS 2 QDs, and I is the fluorescence intensity of DNA-CuInS 2 QDs/GO with the addition of various concentrations of anthrax lethal factor DNA) and the concentration of anthrax lethal factor DNA in the range of 0.029–0.733 nmol L −1 with a detection limit of 0.013 nmol L −1 . The proposed method has been successfully applied to the determination of anthrax lethal factor DNA sequence in human serum samples with satisfactory results. Because of low toxicity and fine biocompatibility, DNA-CuInS 2 QDs also hold potential applications in bioimaging. - Highlights: • Strongly fluorescent DNA-QDs were successfully prepared by a one-pot hydrothermal method with quantum yield up to 23.4%. • A biosensor for label-free detection of anthrax lethal factor DNA was established based on the as-prepared DNA-QDs. • The DNA sensor took advantage of the feature that ssDNA binds to GO with significantly higher affinity than dsDNA. • Good sensitivity and selectivity were obtained. • This method was utilized to detect

  14. One-pot synthesis of strongly fluorescent DNA-CuInS{sub 2} quantum dots for label-free and ultrasensitive detection of anthrax lethal factor DNA

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ziping; Su, Xingguang, E-mail: suxg@jlu.edu.cn

    2016-10-26

    Herein, high quality DNA-CuInS{sub 2} QDs are facilely synthesized through a one-pot hydrothermal method with fluorescence quantum yield as high as 23.4%, and the strongly fluorescent DNA-CuInS{sub 2} QDs have been utilized as a novel fluorescent biosensor for label-free and ultrasensitive detection of anthrax lethal factor DNA. L-Cysteine (L-Cys) and a specific-sequence DNA are used as co-ligands to stabilize the CuInS{sub 2} QDs. The specific-sequence DNA consists of two domains: phosphorothiolates domain (sulfur-containing variants of the usual phosphodiester backbone) controls the nanocrystal passivation and serves as a ligand, and the functional domain (non-phosphorothioates) controls the biorecognition. The as-prepared DNA-CuInS{sub 2} QDs have high stability, good water-solubility and low toxicity. Under the optimized conditions, a linear correlation was established between the fluorescence intensity ratio I/I{sub 0} (I{sub 0} is the original fluorescence intensity of DNA-CuInS{sub 2} QDs, and I is the fluorescence intensity of DNA-CuInS{sub 2} QDs/GO with the addition of various concentrations of anthrax lethal factor DNA) and the concentration of anthrax lethal factor DNA in the range of 0.029–0.733 nmol L{sup −1} with a detection limit of 0.013 nmol L{sup −1}. The proposed method has been successfully applied to the determination of anthrax lethal factor DNA sequence in human serum samples with satisfactory results. Because of low toxicity and fine biocompatibility, DNA-CuInS{sub 2} QDs also hold potential applications in bioimaging. - Highlights: • Strongly fluorescent DNA-QDs were successfully prepared by a one-pot hydrothermal method with quantum yield up to 23.4%. • A biosensor for label-free detection of anthrax lethal factor DNA was established based on the as-prepared DNA-QDs. • The DNA sensor took advantage of the feature that ssDNA binds to GO with significantly higher affinity than dsDNA. • Good sensitivity and selectivity were

  15. Factors affecting the stability of drug-loaded polymeric micelles and strategies for improvement

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Weisai; Li, Caibin; Wang, Zhiyu; Zhang, Wenli, E-mail: zwllz@163.com; Liu, Jianping, E-mail: liujianpingljp@hotmail.com [China Pharmaceutical University, Department of Pharmaceutics (China)

    2016-09-15

    Polymeric micelles (PMs) self-assembled by amphiphilic block copolymers have been used as promising nanocarriers for tumor-targeted delivery due to their favorable properties, such as excellent biocompatibility, prolonged circulation time, favorable particle sizes (10–100 nm) to utilize enhanced permeability and retention effect and the possibility for functionalization. However, PMs can be easily destroyed due to dilution of body fluid and the absorption of proteins in system circulation, which may induce drug leakage from these micelles before reaching the target sites and compromise the therapeutic effect. This paper reviewed the factors that influence stability of micelles in terms of thermodynamics and kinetics consist of the critical micelle concentration of block copolymers, glass transition temperature of hydrophobic segments and polymer–polymer and polymer–cargo interaction. In addition, some effective strategies to improve the stability of micelles were also summarized.Graphical Abstract.

  16. Multiscale Thermohydrologic Model Analyses of Heterogeneity and Thermal-Loading Factors for the Proposed Repository at Yucca Mountain

    International Nuclear Information System (INIS)

    Glascoe, L.G.; Buscheck, T.A.; Gansemer, J.; Sun, Y.; Lee, K.

    2002-01-01

    The MultiScale ThermoHydrologic Model (MSTHM) predicts thermohydrologic (TH) conditions in emplacement drifts and the adjoining host rock throughout the proposed nuclear-waste repository at Yucca Mountain. The MSTHM is a computationally efficient approach that accounts for TH processes occurring at a scale of a few tens of centimeters around individual waste packages and emplacement drifts, and for heat flow at the multi-kilometer scale at Yucca Mountain. The modeling effort presented here is an early investigation of the repository and is simulated at a lower temperature mode and with a different panel loading than the repository currently being considered for license application. We present these recent lower temperature mode MSTHM simulations that address the influence of repository-scale thermal-conductivity heterogeneity and the influence of preclosure operational factors affecting thermal-loading conditions. We can now accommodate a complex repository layout with emplacement drifts lying in non-parallel planes using a superposition process that combines results from multiple mountain-scale submodels. This development, along with other improvements to the MSTHM, enables more rigorous analyses of preclosure operational factors. These improvements include the ability to (1) predict TH conditions on a drift-by-drift basis, (2) represent sequential emplacement of waste packages along the drifts, and (3) incorporate distance- and time-dependent heat-removal efficiency associated with drift ventilation. Alternative approaches to addressing repository-scale thermal-conductivity heterogeneity are investigated. We find that only one of the four MSTHM submodel types needs to incorporate thermal-conductivity heterogeneity. For a particular repository design, we find that the most influential parameters are (1) percolation-flux distribution, (2) thermal-conductivity heterogeneity within the host-rock units, (3) the sequencing of waste-package emplacement, and (4) the

  17. A hybrid filter to mitigate harmonics caused by nonlinear load and resonance caused by power factor correction capacitor

    Science.gov (United States)

    Adan, N. F.; Soomro, D. M.

    2017-01-01

    Power factor correction capacitor (PFCC) is commonly installed in industrial applications for power factor correction (PFC). With the expanding use of non-linear equipment such as ASDs, power converters, etc., power factor (PF) improvement has become difficult due to the presence of harmonics. The resulting capacitive impedance of the PFCC may form a resonant circuit with the source inductive reactance at a certain frequency, which is likely to coincide with one of the harmonic frequency of the load. This condition will trigger large oscillatory currents and voltages that may stress the insulation and cause subsequent damage to the PFCC and equipment connected to the power system (PS). Besides, high PF cannot be achieved due to power distortion. This paper presents the design of a three-phase hybrid filter consisting of a single tuned passive filter (STPF) and shunt active power filter (SAPF) to mitigate harmonics and resonance in the PS through simulation using PSCAD/EMTDC software. SAPF was developed using p-q theory. The hybrid filter has resulted in significant improvement on both total harmonic distortion for voltage (THDV) and total demand distortion for current (TDDI) with maximum values of 2.93% and 9.84% respectively which were within the recommended IEEE 519-2014 standard limits. Regarding PF improvement, the combined filters have achieved PF close to desired PF at 0.95 for firing angle, α values up to 40°.

  18. Strong-back safety latch

    International Nuclear Information System (INIS)

    DeSantis, G.N.

    1995-01-01

    The calculation decides the integrity of the safety latch that will hold the strong-back to the pump during lifting. The safety latch will be welded to the strong-back and will latch to a 1.5-in. dia cantilever rod welded to the pump baseplate. The static and dynamic analysis shows that the safety latch will hold the strong-back to the pump if the friction clamps fail and the pump become free from the strong-back. Thus, the safety latch will meet the requirements of the Lifting and Rigging Manual for under the hook lifting for static loading; it can withstand shock loads from the strong-back falling 0.25 inch

  19. The influence of environmental factors and dredging on chironomid larval diversity in urban drainage systems in polders strongly influenced by seepage from large rivers

    DEFF Research Database (Denmark)

    Vermonden, K.; Brodersen, Klaus Peter; Jacobsen, Dean

    2011-01-01

    , in urban waters strongly influenced by seepage of large rivers. Chironomid assemblages were studied in urban surface-water systems (man-made drainage ditches) in polder areas along lowland reaches of the rivers Rhine-Meuse in The Netherlands. Multivariate analysis was used to identify the key environmental...... factors. Taxon richness, Shannon index (H'), rareness of species, and life-history strategies at urban locations were compared with available data from similar man-made water bodies in rural areas, and the effectiveness of dredging for restoring chironomid diversity in urban waters was tested. Three...... diversity of chironomid communities in urban waters affected by nutrient-rich seepage or inlet of river water...

  20. The combination of energy-dependent internal adaptation mechanisms and external factors enables Listeria monocytogenes to express a strong starvation survival response during multiple-nutrient starvation.

    Science.gov (United States)

    Lungu, Bwalya; Saldivar, Joshua C; Story, Robert; Ricke, Steven C; Johnson, Michael G

    2010-05-01

    The goal of this study was to characterize the starvation survival response (SSR) of a wild-type Listeria monocytogenes 10403S and an isogenic DeltasigB mutant strain during multiple-nutrient starvation conditions over 28 days. This study examined the effects of inhibitors of protein synthesis, the proton motive force, substrate level phosphorylation, and oxidative phosphorylation on the SSR of L. monocytogenes 10403S and a DeltasigB mutant during multiple-nutrient starvation. The effects of starvation buffer changes on viability were also examined. During multiple-nutrient starvation, both strains expressed a strong SSR, suggesting that L. monocytogenes possesses SigB-independent mechanism(s) for survival during multiple-nutrient starvation. Neither strain was able to express an SSR following starvation buffer changes, indicating that the nutrients/factors present in the starvation buffer could be a source of energy for cell maintenance and survival. Neither the wild-type nor the DeltasigB mutant strain was able to elicit an SSR when exposed to the protein synthesis inhibitor chloramphenicol within the first 4 h of starvation. However, both strains expressed an SSR when exposed to chloramphenicol after 6 h or more of starvation, suggesting that the majority of proteins required to elicit an effective SSR in L. monocytogenes are likely produced somewhere between 4 and 6 h of starvation. The varying SSRs of both strains to the different metabolic inhibitors under aerobic or anaerobic conditions suggested that (1) energy derived from the proton motive force is important for an effective SSR, (2) L. monocytogenes utilizes an anaerobic electron transport during multiple-nutrient starvation conditions, and (3) the glycolytic pathway is an important energy source during multiple-nutrient starvation when oxygen is available, and less important under anaerobic conditions. Collectively, the data suggest that the combination of energy-dependent internal adaptation mechanisms

  1. Drift Reliability Assessment of a Four Storey Frame Residential Building Under Seismic Loading Considering Multiple Factors

    Science.gov (United States)

    Sil, Arjun; Longmailai, Thaihamdau

    2017-09-01

    The lateral displacement of Reinforced Concrete (RC) frame building during an earthquake has an important impact on the structural stability and integrity. However, seismic analysis and design of RC building needs more concern due to its complex behavior as the performance of the structure links to the features of the system having many influencing parameters and other inherent uncertainties. The reliability approach takes into account the factors and uncertainty in design influencing the performance or response of the structure in which the safety level or the probability of failure could be ascertained. This present study, aims to assess the reliability of seismic performance of a four storey residential RC building seismically located in Zone-V as per the code provisions given in the Indian Standards IS: 1893-2002. The reliability assessment performed by deriving an explicit expression for maximum roof-lateral displacement as a failure function by regression method. A total of 319, four storey RC buildings were analyzed by linear static method using SAP2000. However, the change in the lateral-roof displacement with the variation of the parameters (column dimension, beam dimension, grade of concrete, floor height and total weight of the structure) was observed. A generalized relation established by regression method which could be used to estimate the expected lateral displacement owing to those selected parameters. A comparison made between the displacements obtained from analysis with that of the equation so formed. However, it shows that the proposed relation could be used directly to determine the expected maximum lateral displacement. The data obtained from the statistical computations was then used to obtain the probability of failure and the reliability.

  2. Lipid-load in peripheral blood mononuclear cells: Impact of food-consumption, dietary-macronutrients, extracellular lipid availability and demographic factors.

    Science.gov (United States)

    Ameer, Fatima; Munir, Rimsha; Usman, Hina; Rashid, Rida; Shahjahan, Muhammad; Hasnain, Shahida; Zaidi, Nousheen

    2017-04-01

    Lipid-load in peripheral blood mononuclear cells (PBMCs) has recently gained attention of the researchers working on nutritional regulation of metabolic health. Previous works have indicated that the metabolic circuitries in the circulating PBMCs are influenced by dietary-intake and macronutrient composition of diet. In the present work, we analyzed the impact of diet and dietary macronutrients on PBMCs' lipid-load. The overall analyses revealed that dietary carbohydrates and fats combinatorially induce triglyceride accumulation in PBMCs. On the other hand, dietary fats were shown to induce significant decrease in PBMCs' cholesterol-load. The effects of various demographic factors -including age, gender and body-weight- on PBMCs' lipid-load were also examined. Body-weight and age were both shown to affect PBMC's lipid-load. Our study fails to provide any direct association between extracellular lipid availability and cholesterol-load in both, freshly isolated and cultured PBMCs. The presented work significantly contributes to the current understanding of the impact of food-consumption, dietary macronutrients, extracellular lipid availability and demographic factors on lipid-load in PBMCs. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  3. Shot loading platform analysis

    International Nuclear Information System (INIS)

    Norman, B.F.

    1994-01-01

    This document provides the wind/seismic analysis and evaluation for the shot loading platform. Hand calculations were used for the analysis. AISC and UBC load factors were used in this evaluation. The results show that the actual loads are under the allowable loads and all requirements are met

  4. A ORACLE-based system for data collection, storage and analysis of main equipment load factors in NPPs and TPPs

    International Nuclear Information System (INIS)

    Ivanova, L.

    1993-01-01

    This data base is developed by the National Electricity Company, Sofia (BG) as an aid to supervision, analysis and administration decision making in a variety of operational situations in NPPs and TPPs. As major indicators of the equipment condition the following primary data are stored: steam or electricity production per month; operation hours per month; equipment stand-by outages; planned outages; unplanned permitted maintenance outages; unplanned emergency maintenance outages; number of outages of the unit per month. These data cover the period from the putting of the corresponding equipment into operation till the present moment, i.e. or about 32 years. The data up to 1990 are annual and for the last three years - monthly. Based on these primary data, the following quantities are calculated: average capacity; average load factors; operation time factors - total and accounting for the planned and the permitted unplanned outages; unpermitted outages factors - total and accounting for the planned and the permitted outages. All the factors are calculated on user's request for a chosen time period, by summing up correspondingly the major indicators (production, operation hours and various outages) for the given period. The system operates on an IBM 4341 under VM/SP and DB ORACLE V.5. The input is entered directly from the TPP and NPP by telex lines from PCs, operating also as telex machines, into the mainframe of Energokibernetika Ltd. They are available to all authorised users from local terminals or PCs, connected to the computer by synchronous or asynchronous lines. A system for data transmission to remote users along commutated telephone lines is also developed. (R. Ts.)

  5. Optimization of 10 kW solar photovoltaic – diesel generator hybrid energy system for different load factors at Jaisalmer location of Rajasthan, India

    Science.gov (United States)

    Saraswat, S. K.; Rao, K. V. S.

    2018-03-01

    Jaisalmer town in Rajasthan, India is having annual average solar insolation of 5.80 kWh/m2/day and 270 – 300 clear sky days in a year. A 10 kW off-grid hybrid energy system (HES) consisting of solar photovoltaic panels – diesel generator – bidirectional converter and batteries with zero percentage loss of load for Jaisalmer is designed using HOMER (version 3.4.3) software. Different system load factors of 0.33, 0.50, 0.67, 0.83 and 1 corresponding to fraction of running hours per day of the system are considered. The system is analyzed for all three aspects, namely, electrical, economic and emission point of view. Least levelized cost of electricity (LCOE) of Rs. 8.43/kWh is obtained at a load factor value of 0.5. If diesel generator alone (without Solar PV) is used to fulfil the demand for a load factor of 0.5the value of LCOE is obtained Rs.19.23/kWh. Comparison of results obtained for HES and diesel generator are made for load factor of 0.5 and 1.

  6. Regulation of the Dynamic Live Load Factor for Calculation of Bridge Structures on High-Speed Railway Mainlines

    Science.gov (United States)

    Dyachenko, Leonid K.; Benin, Andrey V.

    2017-06-01

    When the high-speed railway traffic is being organized, it becomes necessary to elaborate bridge design standards for high-speed railways (HSR). Methodology of studying the issues of HSR bridge design is based on the comprehensive analysis of domestic research as well as international experience in design, construction and operation of high-speed railways. Serious requirements are imposed on the HSR artificial structures, which raise a number of scientific tasks associated mainly with the issues of the dynamic interaction of the rolling stock and the bridge elements. To ensure safety of traffic and reliability of bridges during the whole period of operation one needs to resolve the dynamic problems of various types of high-speed trains moving along the structures. The article analyses dependences of the magnitude of inertial response on the external stress parameters and proposes a simplified method of determination of the dynamic live load factor caused by the passage of high-speed trains. The usefulness of the given research arises from the reduction of complexity of the complicated dynamic calculations needed to describe a high-speed train travelling along the artificial structures.

  7. Regulation of the Dynamic Live Load Factor for Calculation of Bridge Structures on High-Speed Railway Mainlines

    Directory of Open Access Journals (Sweden)

    Dyachenko Leonid K.

    2017-06-01

    Full Text Available When the high-speed railway traffic is being organized, it becomes necessary to elaborate bridge design standards for high-speed railways (HSR. Methodology of studying the issues of HSR bridge design is based on the comprehensive analysis of domestic research as well as international experience in design, construction and operation of high-speed railways. Serious requirements are imposed on the HSR artificial structures, which raise a number of scientific tasks associated mainly with the issues of the dynamic interaction of the rolling stock and the bridge elements. To ensure safety of traffic and reliability of bridges during the whole period of operation one needs to resolve the dynamic problems of various types of high-speed trains moving along the structures. The article analyses dependences of the magnitude of inertial response on the external stress parameters and proposes a simplified method of determination of the dynamic live load factor caused by the passage of high-speed trains. The usefulness of the given research arises from the reduction of complexity of the complicated dynamic calculations needed to describe a high-speed train travelling along the artificial structures.

  8. Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load

    Directory of Open Access Journals (Sweden)

    Ana Júlia Luz

    Full Text Available OBJECTIVE: To evaluate the factors associated with plasma concentrations of atazanavir (ATV in a cohort of well-controlled HIV infected subjects (undetectable viremia. Design: Cross-sectional study where 69 subjects were consecutively enrolled between April and November, 2011. METHODS: Patients had to be on atazanavir for at least six months, undetectable viral load for a period equal to or longer than 12 months, T CD4+ lymphocyte count higher than 200 cells/mm³, and aged between 18 years and 70 years old. Exclusion criteria were pregnancy, any neurologic disease, active opportunistic disease, hepatitis or cancer. Atazanavir plasma levels were measured by ultra-performance liquid chromatography. RESULTS AND DISCUSSION: Overall, 54 patients (mean age of 47 years and 50% women were included in the analysis. Those without ritonavir (unboosted atazanavir had statistically lower plasma concentrations than those with ritonavir boosted atazanavir (p = 0.001 and total and indirect bilirubin were statistically associated with plasma concentration of atazanavir (r = 0.32 and r = 0.33 respectively; p < 0.05 in both cases. no statistical association was found among gender, ethnicity, age, weight, body mass index (BMI, lipid profile, and the plasma concentration of atazanavir. CONCLUSION: in summary, as expected, concomitant ritonavir use was the only factor associated with atazanavir plasma levels. prospective studies with a larger sample size might help to observe an association of atazanavir concentrations to other characteristics such as body weight, since the p-value showed to be close to significance (p = 0.068.

  9. The Mediterranean Diet Score Is More Strongly Associated with Favorable Cardiometabolic Risk Factors over 2 Years Than Other Diet Quality Indexes in Puerto Rican Adults.

    Science.gov (United States)

    Mattei, Josiemer; Sotos-Prieto, Mercedes; Bigornia, Sherman J; Noel, Sabrina E; Tucker, Katherine L

    2017-04-01

    Background: Multiple diet quality scores have been used to evaluate adherence to specific dietary recommendations or to consumption of healthful foods and nutrients. It remains unknown which score can more strongly predict longitudinal changes in cardiometabolic risk factors. Objective: We aimed to determine associations of 5 diet quality scores [AHA diet score (AHA-DS), Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index (HEI)-2005, Mediterranean diet score (MeDS), and Alternative Healthy Eating Index (AHEI)] with 2-y changes in cardiometabolic risk factors in adults 45-75 y old. Methods: Data from the Boston Puerto Rican Health Study were analyzed ( n = 1194). Diet quality scores were calculated from a baseline-validated food-frequency questionnaire. Multivariable-adjusted, repeated-subjects, mixed-effects models, adjusted for baseline measures, estimated associations between each z score and 14 individual cardiometabolic factors measured at 2 y. Results: MeDS was significantly associated with lower 2-y waist circumference (β coefficient ± SE: -0.52 ± 0.26, P = 0.048); body mass index (BMI; -0.23 ± 0.08, P = 0.005); log-insulin (-0.06 ± 0.02, P = 0.005); log-homeostasis model assessment of insulin resistance (HOMA-IR; -0.05 ± 0.02, P = 0.030), and log-C-reactive protein (-0.13 ± 0.03, P = 0.0002). Similar but weaker associations were observed for the AHEI with BMI, insulin, and HOMA-IR. The AHA-DS was inversely associated with BMI (-0.17 ± 0.08, P = 0.033). Neither the HEI-2005 nor DASH was significantly associated with any variable. Traditional Puerto Rican foods consumed by individuals with high MeDSs included vegetables and meats in homemade soups, orange juice, oatmeal, beans and legumes, fish, whole milk, corn oil, and beer. Conclusions: The MeDS comprises food components and scores associated with a favorable cardiometabolic profile over 2 y in Puerto Rican adults. An overall healthy diet may be particularly beneficial for

  10. Calculating load factors for the transatlantic airline market using supply and demand data: a note on the identification of gaps in the available airline statistics

    NARCIS (Netherlands)

    Devriendt, L.; Burghouwt, G.; Derudder, B.; de Wit, J.; Witlox, F.

    2009-01-01

    This paper takes a critical view of the verification of load factors for the direct transatlantic airline market by combining supply and demand-data. The supply-related data originate from the Official Airline Guide, a well-known data source that contains information on scheduled flights. The

  11. Factors influencing storm-generated suspended-sediment concentrations and loads in four basins of contrasting land use, humid-tropical Puerto Rico

    Science.gov (United States)

    A. C. Gellis; NO-VALUE

    2013-01-01

    The significant characteristics controlling the variability in storm-generated suspended-sediment loads and concentrations were analyzed for four basins of differing land use (forest, pasture, cropland, and urbanizing) in humid-tropical Puerto Rico. Statistical analysis involved stepwise regression on factor scores. The explanatory variables were attributes of flow,...

  12. Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.

    Directory of Open Access Journals (Sweden)

    Luisina I Onofrio

    2015-02-01

    Full Text Available The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH, and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood.We evaluated immunological parameters in male C57BL/6 wild type and TLR4 deficient mice fed with a standard, low fat diet, LFD (3% fat as control group, or a medium fat diet, MFD (14% fat in order to induce NASH, or mice infected intraperitoneally with 100 blood-derived trypomastigotes of Tulahuen strain and also fed with LFD (I+LFD or MFD (I+MFD for 24 weeks. We demonstrated that MFD by itself was able to induce NASH in WT mice and that parasitic infection induced marked metabolic changes with reduction of body weight and steatosis revealed by histological studies. The I+MFD group also improved insulin resistance, demonstrated by homeostasis model assessment of insulin resistance (HOMA-IR analysis; although parasitic infection increased the triglycerides and cholesterol plasma levels. In addition, hepatic M1 inflammatory macrophages and cytotoxic T cells showed intracellular inflammatory cytokines which were associated with high levels of IL6, IFNγ and IL17 plasmatic cytokines and CCL2 chemokine. These findings correlated with an increase in hepatic parasite load in I+MFD group demonstrated by qPCR assays. The recruitment of hepatic B lymphocytes, NK and dendritic cells was enhanced by MFD, and it was intensified by parasitic infection. These results were TLR4 signaling dependent. Flow cytometry and confocal microscopy analysis demonstrated that the reactive oxygen species and peroxinitrites produced by liver inflammatory leukocytes of MFD group were also exacerbated by parasitic infection in our NASH model.We highlight that a medium fat diet by itself is able to induce steatohepatitis. Our results also suggest a synergic effect between damage associated with molecular patterns generated during NASH and parasitic infection

  13. Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants

    Directory of Open Access Journals (Sweden)

    Pao-Hwa Lin

    2012-06-01

    Full Text Available Background: The clinical significance of glycemic index (GI and glycemic load (GL is inconclusive. Objective : This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD risk factors including body weight, blood pressure (BP, serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC change only (p<0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L with a significant age interaction. The GL change was significantly associated with TC (p=0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L positively and with low density lipoprotein cholesterol (LDL-C changes negatively (p=0.03, β = − 0.01±0.00 mg/dL or −0.00±0.00 mmol/L, and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

  14. Elongation Factor Tu and Heat Shock Protein 70 Are Membrane-Associated Proteins from Mycoplasma ovipneumoniae Capable of Inducing Strong Immune Response in Mice.

    Directory of Open Access Journals (Sweden)

    Fei Jiang

    Full Text Available Chronic non-progressive pneumonia, a disease that has become a worldwide epidemic has caused considerable loss to sheep industry. Mycoplasma ovipneumoniae (M. ovipneumoniae is the causative agent of interstitial pneumonia in sheep, goat and bighorn. We here have identified by immunogold and immunoblotting that elongation factor Tu (EF-Tu and heat shock protein 70 (HSP 70 are membrane-associated proteins on M. ovipneumonaiea. We have evaluated the humoral and cellular immune responses in vivo by immunizing BALB/c mice with both purified recombinant proteins rEF-Tu and rHSP70. The sera of both rEF-Tu and rHSP70 treated BALB/c mice demonstrated increased levels of IgG, IFN-γ, TNF-α, IL-12(p70, IL-4, IL-5 and IL-6. In addition, ELISPOT assay showed significant increase in IFN-γ+ secreting lymphocytes in the rHSP70 group when compared to other groups. Collectively our study reveals that rHSP70 induces a significantly better cellular immune response in mice, and may act as a Th1 cytokine-like adjuvant in immune response induction. Finally, growth inhibition test (GIT of M. ovipneumoniae strain Y98 showed that sera from rHSP70 or rEF-Tu-immunized mice inhibited in vitro growth of M. ovipneumoniae. Our data strongly suggest that EF-Tu and HSP70 of M. ovipneumoniae are membrane-associated proteins capable of inducing antibody production, and cytokine secretion. Therefore, these two proteins may be potential candidates for vaccine development against M. ovipneumoniae infection in sheep.

  15. MYB and bHLH transcription factor transgenes increase anthocyanin pigmentation in petunia and lisianthus plants, and the petunia phenotypes are strongly enhanced under field conditions

    Directory of Open Access Journals (Sweden)

    Kathy E Schwinn

    2014-11-01

    Full Text Available Petunia line Mitchell [MP, Petunia axillaris × (P. axillaris × P. hybrida] and Eustoma grandiflorum (lisianthus plants were produced containing a transgene for over-expression of the R2R3-MYB transcription factor (ROSEA1 that up-regulates flavonoid biosynthesis in Antirrhinum majus. The petunia lines were also crossed with previously produced MP lines containing a Zea mays flavonoid-related bHLH transcription factor transgene (LEAF COLOR, LC, which induces strong vegetative pigmentation when these 35S:LC plants are exposed to high light levels. 35S:ROS1 lisianthus transgenics had limited changes in anthocyanin pigmentation, specifically, precocious pigmentation of flower petals and increased pigmentation of sepals. RNA transcript levels for two anthocyanin biosynthetic genes, chalcone synthase and anthocyanidin synthase, were increased in the 35S:ROS1 lisianthus petals compared to those of control lines. With MP, the 35S:ROS1 calli showed novel red pigmentation in culture, but this was generally not seen in tissue culture plantlets regenerated from the calli or young plants transferred to soil in the greenhouse. Anthocyanin pigmentation was enhanced in the stems of mature 35S:ROS1 MP plants, but the MP white-flower phenotype was not complemented. Progeny from a 35S:ROS1×35S:LC cross had novel pigmentation phenotypes that were not present in either parental line or MP. In particular, there was increased pigment accumulation in the petal throat region, and the anthers changed from yellow to purple colour. An outdoor field trial was conducted with the 35S:ROS1, 35S:LC, 35S:ROS1×35S:LC and control MP lines. Field conditions rapidly induced intense foliage pigmentation in 35S:LC plants, a phenotype not observed in control MP or equivalent 35S:LC plants maintained in a greenhouse. No difference in plant stature, seed germination, or plant survival was observed between transgenic and control plants.

  16. Factors affecting the potential of direct load control for non-generating utilities. Final report. [Distribution and wholesale power supply interaction

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-01

    Several alternatives are available for achieving load management, including direct or voluntary control of customer loads, customer or utility energy storage systems for diurnal load shifting, and expanded interconnection and operation of electric power systems. All of these alternatives are available to the fully integrated (generating, transmitting and distributing) electric utility and the analysis of their effects encompasses the power supply and delivery system. However, the costs and benefits of the alternatives to the fully integrated electric utility are perhaps not so obvious. Therefore, by considering a non-generating utility, this analysis focuses upon the distribution system and wholesale power supply interaction as a step toward an analysis including the power supply and delivery system. This report develops an analysis procedure and discusses some of the relevant factors to be consdered in the application of direct load control for a non-generating utility system. The analysis concentrates on the distribution system only to determine the effect of rates and payback as a result of direct load control. Thus, the study is responsive to the specific needs of the non-generating utility. This analysis of direct load control encompasses the determination of those loads amenable to control, the selection of a suitable one-way communications system to rend control and the estimation of expected benefits and costs. The complementary functions to the application of direct load control such as automatic meter reading via the addition of a bi-directional communications system and voltage control are not included in the analysis but are detailed for future consideration.

  17. Factors related to external loads in buried pipelines; Consideracoes quanto as variaveis relacionadas ao carregamento externo em dutos enterrados

    Energy Technology Data Exchange (ETDEWEB)

    Provenzano, Carlos E.C.; Silva, Breno S.; Fernandes, Lincoln F.; Santos Junior, Sergio J.F. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Louzada, Carlos H.C.M.

    2005-07-01

    Work of heavy equipment or vehicles above existent right-of-ways, may cause undesired external overload at buried pipelines in operation. The effect of these loads shall be analyzed considering the deflections and stresses on the pipelines. The major variables, nominal diameter, thickness, material, soil parameters, operation pressure and external loads shall be related and verified according to the limits from original project. Cases when the external loads cause higher efforts, the traffic over the pipelines shall be restricted in order to avoid damages. In other cases, it may be adapted to any technical alternatives to modify the parameters in such a way to make possible work above the right-of-way, such as increase the machine support area, increase backfill covering, a reduction in the internal operation pressure in a short time, etc. This work presents the study on the parameters used to establish the maximum allowable external loads over buried pipelines in operation. (author)

  18. [Estimation of urban non-point source pollution loading and its factor analysis in the Pearl River Delta].

    Science.gov (United States)

    Liao, Yi-Shan; Zhuo, Mu-Ning; Li, Ding-Qiang; Guo, Tai-Long

    2013-08-01

    In the Pearl Delta region, urban rivers have been seriously polluted, and the input of non-point source pollution materials, such as chemical oxygen demand (COD), into rivers cannot be neglected. During 2009-2010, the water qualities at eight different catchments in the Fenjiang River of Foshan city were monitored, and the COD loads for eight rivulet sewages were calculated in respect of different rainfall conditions. Interesting results were concluded in our paper. The rainfall and landuse type played important roles in the COD loading, with greater influence of rainfall than landuse type. Consequently, a COD loading formula was constructed that was defined as a function of runoff and landuse type that were derived SCS model and land use map. Loading of COD could be evaluated and predicted with the constructed formula. The mean simulation accuracy for single rainfall event was 75.51%. Long-term simulation accuracy was better than that of single rainfall. In 2009, the estimated COD loading and its loading intensity were 8 053 t and 339 kg x (hm2 x a)(-1), and the industrial land was regarded as the main source of COD pollution area. The severe non-point source pollution such as COD in Fenjiang River must be paid more attention in the future.

  19. HIV-1 infection, but not syphilis or HBV infection, is a strong risk factor for anorectal condyloma in Asian population: A prospective colonoscopy screening study

    Directory of Open Access Journals (Sweden)

    Takeshi Nishijima

    2015-08-01

    Conclusions: HIV-1 infection, but not syphilis or HBV infection, was identified as a strong risk for anorectal condyloma. Anal HPV 16/18 was highly prevalent in patients with HIV-1 infection, especially in those with condyloma.

  20. Cloning of the DNA-binding subunit of human nuclear factor κB: The level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor α

    International Nuclear Information System (INIS)

    Meyer, R.; Hatada, E.N.; Bartsch, C.; Scheidereit, C.; Hohmann, H.P.; Haiker, M.; Roethlisberger, U.; Lahm, H.W.; Schlaeger, E.J.; van Loon, A.P.G.M.

    1991-01-01

    The DNA binding subunit of nuclear factor κB (NF-κB), a B-cell protein that interacts with the immunoglobulin κ light-chain gene enhancer, has been purified from nuclei of human HL-60 cells stimulated with tumor necrosis factor α (TNFα), and internal peptide sequences were obtained. Overlapping cDNA clones were isolated and sequenced. The encoded open reading frame of about 105 kDa contained at its N-terminal half all six tryptic peptide sequences, suggesting that the 51-kDa NF-κB protein is processed from a 105-kDa precursor. An in vitro synthesized protein containing most of the N-terminal half of the open reading frame bound specifically to an NF-κB binding site. This region also showed high homology to a domain shared by the Drosophila dorsal gene and the avian and mammalian rel (proto)oncogene products. The level of the 3.8-kilobase mRNA was strongly increased after stimulation with TNFα or phorbol ester. Thus, both factors not only activate NF-κB protein, as described previously, but also induce expression of the gene encoding the DNA-binding subunit of NF-κB

  1. MYB and bHLH transcription factor transgenes increase anthocyanin pigmentation in petunia and lisianthus plants, and the petunia phenotypes are strongly enhanced under field conditions

    Science.gov (United States)

    Schwinn, Kathy E.; Boase, Murray R.; Bradley, J. Marie; Lewis, David H.; Deroles, Simon C.; Martin, Cathie R.; Davies, Kevin M.

    2014-01-01

    Petunia line Mitchell [MP, Petunia axillaris × (P. axillaris × P. hybrida)] and Eustoma grandiflorum (lisianthus) plants were produced containing a transgene for over-expression of the R2R3-MYB transcription factor [TF; ROSEA1 (ROS1)] that up-regulates flavonoid biosynthesis in Antirrhinum majus. The petunia lines were also crossed with previously produced MP lines containing a Zea mays flavonoid-related basic helix-loop-helix TF transgene (LEAF COLOR, LC), which induces strong vegetative pigmentation when these 35S:LC plants are exposed to high-light levels. 35S:ROS1 lisianthus transgenics had limited changes in anthocyanin pigmentation, specifically, precocious pigmentation of flower petals and increased pigmentation of sepals. RNA transcript levels for two anthocyanin biosynthetic genes, chalcone synthase and anthocyanidin synthase, were increased in the 35S:ROS1 lisianthus petals compared to those of control lines. With MP, the 35S:ROS1 calli showed novel red pigmentation in culture, but this was generally not seen in tissue culture plantlets regenerated from the calli or young plants transferred to soil in the greenhouse. Anthocyanin pigmentation was enhanced in the stems of mature 35S:ROS1 MP plants, but the MP white-flower phenotype was not complemented. Progeny from a 35S:ROS1 × 35S:LC cross had novel pigmentation phenotypes that were not present in either parental line or MP. In particular, there was increased pigment in the petal throat region, and the anthers changed from yellow to purple pigmentation. An outdoor field trial was conducted with the 35S:ROS1, 35S:LC, 35S:ROS1 × 35S:LC and control MP lines. Field conditions rapidly induced intense foliage pigmentation in 35S:LC plants, a phenotype not observed in control MP or equivalent 35S:LC plants maintained in a greenhouse. No difference in plant stature, seed germination, or plant survival was observed between transgenic and control plants. PMID:25414715

  2. Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load EPF-ANRS CO1).

    Science.gov (United States)

    Tubiana, Roland; Le Chenadec, Jerome; Rouzioux, Christine; Mandelbrot, Laurent; Hamrene, Karima; Dollfus, Catherine; Faye, Albert; Delaugerre, Constance; Blanche, Stephane; Warszawski, Josiane

    2010-02-15

    The rate of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) type 1 is as low as 0.5% in non-breast-feeding mothers who delivered at term while receiving antiretroviral therapy with a plasma viral load <500 copies/mL. This situation accounted for 20% of the infected children born during the period 1997-2006 in the French Perinatal Cohort. We aimed to identify factors associated with such residual transmission risk. We performed a case-control study nested in the aforementioned subpopulation of the French Perinatal Cohort. Nineteen case patients (transmitters) and 60 control subjects (nontransmitters) were included. Case patients and control subjects did not differ by geographical origin, gestational age at HIV diagnosis, type of antiretroviral therapy received, or elective Cesarean delivery. Case patients were less often receiving treatment at the time that they conceived pregnancy than control subjects (16% vs 45%; P=.017). A lower proportion of case patients had a viral load <500 copies/mL, compared with control subjects, at 14 weeks (0% vs 38.1%; P=.02), 28 weeks (7.7% vs 62.1%; P=.005), and 32 weeks: (21.4% vs 71.1%; P=.004). The difference remained significant when we restricted analysis to the 10 of 16 intrapartum transmission cases. In a multivariate analysis at 30+/-4 weeks adjusted for viral load, CD4(+) T cell count, and time at antiretroviral therapy initiation, viral load was the only factor independently associated with MTCT of HIV (adjusted odds ratio, 23.2; 95% confidence interval, 3.5-553; P<.001). Early and sustained control of viral load is associated with a decreasing residual risk of MTCT of HIV-1. Guidelines should take into account not only CD4(+) T cell count and risk of preterm delivery, but also baseline HIV-1 load for deciding when to start antiretroviral therapy during pregnancy.

  3. The Flynn effect, group differences, and g loadings

    NARCIS (Netherlands)

    te Nijenhuis, J.

    2013-01-01

    Flynn effect gains are predominantly driven by environmental factors. Might these factors also be responsible for group differences in intelligence? Group differences in intelligence have been clearly shown to strongly correlate with g loadings. The empirical studies on whether the pattern of Flynn

  4. Mechanical loading by fluid shear stress of myotube glycocalyx stimulates growth factor expression and nitric oxide production

    NARCIS (Netherlands)

    Juffer, P.; Bakker, A.D.; Klein-Nulend, J.; Jaspers, R.T.

    2014-01-01

    Skeletal muscle fibers have the ability to increase their size in response to a mechanical overload. Finite element modeling data suggest that mechanically loaded muscles in vivo may experience not only tensile strain but also shear stress. However, whether shear stress affects biological pathways

  5. Depressive symptoms in middle-aged women are more strongly associated with physical health and social support than with socioeconomic factors

    DEFF Research Database (Denmark)

    Aro, A R; Nyberg, N; Absetz, P

    2001-01-01

    The association of socioeconomic factors, health-related factors, and social support with depressive symptoms has been extensively studied. However, most epidemiological studies have focused on a few factors such as marital status, social class, and employment. In this study of middle-aged women we...... analyzed both univariate and multivariate associations of socioeconomic factors, perceived physical health factors, and social support with self-rated depressive symptoms measured with the Beck Depression Inventory. A nationwide sample (n = 1851) of Finnish women aged 48-50 years was analyzed....... Socioeconomic, health-related, and social support factors were all measured with single items. All variables, except level of urbanization, were significantly associated with depressive symptoms in univariate analyses. Multivariate associations were examined with standard multiple regression analyses in three...

  6. Parasite load and risk factors for poor outcome among children with visceral leishmaniasis. A cohort study in Belo Horizonte, Brazil, 2010-2011

    Directory of Open Access Journals (Sweden)

    Maria Vitória Assumpção Mourão

    2014-04-01

    Full Text Available Clinical and laboratory risk factors for death from visceral leishmaniasis (VL are relatively known, but quantitative real-time polymerase chain reaction (qPCR might assess the role of parasite load in determining clinical outcome. The aim of this study was to identify risk factors, including parasite load in peripheral blood, for VL poor outcome among children. This prospective cohort study evaluated children aged ≤ 12 years old with VL diagnosis at three times: pre-treatment (T0, during treatment (T1 and post-treatment (T2. Forty-eight patients were included and 16 (33.3% met the criteria for poor outcome. Age ≤ 12 months [relative risk (RR 3.51; 95% confidence interval (CI 1.89-6.52], tachydyspnoea (RR 3.46; 95% CI 2.19-5.47, bacterial infection (RR 3.08; 95% CI 1.27-7.48, liver enlargement (RR 3.00; 95% CI 1.44-6.23 and low serum albumin (RR 7.00; 95% CI 1.80-27.24 were identified as risk factors. qPCR was positive in all patients at T0 and the parasite DNA was undetectable in 76.1% of them at T1 and in 90.7% at T2. There was no statistical association between parasite load at T0 and poor outcome.

  7. Does IQ predict total and cardiovascular disease mortality as strongly as other risk factors? Comparison of effect estimates using the Vietnam Experience Study

    DEFF Research Database (Denmark)

    Batty, G D; Shipley, M J; Gale, C R

    2008-01-01

    To compare the strength of the relation of two measurements of IQ and 11 established risk factors with total and cardiovascular disease (CVD) mortality.......To compare the strength of the relation of two measurements of IQ and 11 established risk factors with total and cardiovascular disease (CVD) mortality....

  8. Attentional capture under high perceptual load.

    Science.gov (United States)

    Cosman, Joshua D; Vecera, Shaun P

    2010-12-01

    Attentional capture by abrupt onsets can be modulated by several factors, including the complexity, or perceptual load, of a scene. We have recently demonstrated that observers are less likely to be captured by abruptly appearing, task-irrelevant stimuli when they perform a search that is high, as opposed to low, in perceptual load (Cosman & Vecera, 2009), consistent with perceptual load theory. However, recent results indicate that onset frequency can influence stimulus-driven capture, with infrequent onsets capturing attention more often than did frequent onsets. Importantly, in our previous task, an abrupt onset was present on every trial, and consequently, attentional capture might have been affected by both onset frequency and perceptual load. In the present experiment, we examined whether onset frequency influences attentional capture under conditions of high perceptual load. When onsets were presented frequently, we replicated our earlier results; attentional capture by onsets was modulated under conditions of high perceptual load. Importantly, however, when onsets were presented infrequently, we observed robust capture effects. These results conflict with a strong form of load theory and, instead, suggest that exposure to the elements of a task (e.g., abrupt onsets) combines with high perceptual load to modulate attentional capture by task-irrelevant information.

  9. Epstein-Barr virus: general factors, virus-related diseases and measurement of viral load after transplant

    Directory of Open Access Journals (Sweden)

    Luciana Cristina Fagundes Gequelin

    2011-10-01

    Full Text Available The Epstein-Barr virus is responsible for infectious mononucleosis syndrome and is also closely associated to several types of cancer. The main complication involving Epstein-Barr virus infection, both in recipients of hematopoietic stem cells and solid organs, is post-transplant lymphoproliferative disease. The importance of this disease has increased interest in the development of laboratory tools to improve post-transplant monitoring and to detect the disease before clinical evolution. Viral load analysis for Epstein-Barr virus through real-time polymerase chain reaction is, at present, the best tool to measure viral load. However, there is not a consensus on which sample type is the best for the test and what is its predictive value for therapeutic interventions.

  10. Load-Dependent Emission Factors and Chemical Characteristics of IVOCs from a Medium-Duty Diesel Engine.

    Science.gov (United States)

    Cross, Eben S; Sappok, Alexander G; Wong, Victor W; Kroll, Jesse H

    2015-11-17

    A detailed understanding of the climate and air quality impacts of mobile-source emissions requires the characterization of intermediate-volatility organic compounds (IVOCs), relatively-low-vapor-pressure gas-phase species that may generate secondary organic aerosol with high yields. Due to challenges associated with IVOC detection and quantification, IVOC emissions remain poorly understood at present. Here, we describe measurements of the magnitude and composition of IVOC emissions from a medium-duty diesel engine. Measurements are made on an engine dynamometer and utilize a new mass-spectrometric instrument to characterize the load dependence of the emissions in near-real-time. Results from steady-state engine operation indicate that IVOC emissions are highly dependent on engine power, with highest emissions at engine idle and low-load operation (≤25% maximum rated power) with a chemical composition dominated by saturated hydrocarbon species. Results suggest that unburned fuel components are the dominant IVOCs emitted at low loads. As engine load increases, IVOC emissions decline rapidly and become increasingly characterized by unsaturated hydrocarbons and oxygenated organics, newly formed from incomplete combustion processes at elevated engine temperatures and pressures. Engine transients, including a cold-start ignition and engine acceleration, show IVOC emission profiles that are different in amount or composition compared to steady-state combustion, underscoring the utility of characterizing IVOC emissions with high time resolution across realistic engine operating conditions. We find possible evidence for IVOC losses on unheated dilution and sampling surfaces, which need to be carefully accounted for in IVOC emission studies.

  11. Impact of Bulldozer's Engine Load Factor on Fuel Consumption, CO2 Emission and Cost

    OpenAIRE

    V. Kecojevic; D. Komljenovic

    2011-01-01

    Problem statement: Bulldozers consume a large amount of diesel fuel and consequently produce a significant quantity of CO2. Environmental and economic cost issues related to fuel consumption and CO2 emission represent a substantial challenge to the mining industry. Approach: Impact of engine load conditions on fuel consumption and the subsequent CO2 emission and cost was analyzed for Caterpillar bulldozers. Results were compared with the data on bulldozers' fuel consu...

  12. Testing strong factorial invariance using three-level structural equation modeling

    NARCIS (Netherlands)

    Jak, Suzanne

    Within structural equation modeling, the most prevalent model to investigate measurement bias is the multigroup model. Equal factor loadings and intercepts across groups in a multigroup model represent strong factorial invariance (absence of measurement bias) across groups. Although this approach is

  13. Polymerization of aniline: in the solutions of strong and weak acids: The evolution of infrared spectra and their interpretation using factor analysis

    Czech Academy of Sciences Publication Activity Database

    Šeděnková, Ivana; Trchová, Miroslava; Stejskal, Jaroslav; Bok, J.

    2007-01-01

    Roč. 61, č. 11 (2007), s. 1153-1162 ISSN 0003-7028 R&D Projects: GA AV ČR IAA4050313; GA AV ČR IAA400500504 Institutional research plan: CEZ:AV0Z40500505 Keywords : conducting polymer * thin films * polyaniline Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.902, year: 2007

  14. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles

    NARCIS (Netherlands)

    Wilson, A. G.; de Vries, N. [=Niek; Pociot, F.; di Giovine, F. S.; van der Putte, L. B.; Duff, G. W.

    1993-01-01

    The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies

  15. Strongly Anisotropic Electronic Transport at Landau Level Filling Factor ν =9/2 and ν =5/2 under a Tilted Magnetic Field

    International Nuclear Information System (INIS)

    Pan, W.; Tsui, D.C.; Pan, W.; Du, R.R.; Du, R.R.; Stormer, H.L.; Pfeiffer, L.N.; Baldwin, K.W.; West, K.W.; Stormer, H.L.; Stormer, H.L.

    1999-01-01

    We have investigated the influence of an increasing in-plane magnetic field on the states of half filling of Landau levels (ν=11/2, 9/2, 7/2, thinspandthinsp 5/2) of a two-dimensional electron system. In the electrically anisotropic phase at ν=9/2 and 11/2 an in-plane magnetic field of ∼1 - 2 T overcomes its initial pinning to the crystal lattice and reorients this phase. In the initially isotropic phases at ν=5/2 and 7/2 an in-plane magnetic field induces a strong electrical anisotropy. In all cases, for high in-plane fields the high-resistance axis is parallel to the direction of the in-plane field. copyright 1999 The American Physical Society

  16. Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

    Science.gov (United States)

    2012-01-01

    Background MicroRNA (miRNA) target genes tend to have relatively long and conserved 3' untranslated regions (UTRs), but to what degree these characteristics contribute to miRNA targeting is poorly understood. Different high-throughput experiments have, for example, shown that miRNAs preferentially regulate genes with both short and long 3' UTRs and that target site conservation is both important and irrelevant for miRNA targeting. Results We have analyzed several gene context-dependent features, including 3' UTR length, 3' UTR conservation, and messenger RNA (mRNA) expression levels, reported to have conflicting influence on miRNA regulation. By taking into account confounding factors such as technology-dependent experimental bias and competition between transfected and endogenous miRNAs, we show that two factors - target gene expression and competition - could explain most of the previously reported experimental differences. Moreover, we find that these and other target site-independent features explain about the same amount of variation in target gene expression as the target site-dependent features included in the TargetScan model. Conclusions Our results show that it is important to consider confounding factors when interpreting miRNA high throughput experiments and urge special caution when using microarray data to compare average regulatory effects between groups of genes that have different average gene expression levels. PMID:22325809

  17. Low-momentum dynamic structure factor of a strongly interacting Fermi gas at finite temperature: A two-fluid hydrodynamic description

    Science.gov (United States)

    Hu, Hui; Zou, Peng; Liu, Xia-Ji

    2018-02-01

    We provide a description of the dynamic structure factor of a homogeneous unitary Fermi gas at low momentum and low frequency, based on the dissipative two-fluid hydrodynamic theory. The viscous relaxation time is estimated and is used to determine the regime where the hydrodynamic theory is applicable and to understand the nature of sound waves in the density response near the superfluid phase transition. By collecting the best knowledge on the shear viscosity and thermal conductivity known so far, we calculate the various diffusion coefficients and obtain the damping width of the (first and second) sounds. We find that the damping width of the first sound is greatly enhanced across the superfluid transition and very close to the transition the second sound might be resolved in the density response for the transferred momentum up to half of Fermi momentum. Our work is motivated by the recent measurement of the local dynamic structure factor at low momentum at Swinburne University of Technology and the ongoing experiment on sound attenuation of a homogeneous unitary Fermi gas at Massachusetts Institute of Technology. We discuss how the measurement of the velocity and damping width of the sound modes in low-momentum dynamic structure factor may lead to an improved determination of the universal superfluid density, shear viscosity, and thermal conductivity of a unitary Fermi gas.

  18. Three Dimensional Parametric Analyses of Stress Concentration Factor and Its Mitigation in Isotropic and Orthotropic Plate with Central Circular Hole Under Axial In-Plane Loading

    Science.gov (United States)

    Nagpal, Shubhrata; Jain, Nitin Kumar; Sanyal, Shubhashis

    2016-01-01

    The problem of finding the stress concentration factor of a loaded rectangular plate has offered considerably analytical difficulty. The present work focused on understanding of behavior of isotropic and orthotropic plate subjected to static in-plane loading using finite element method. The complete plate model configuration has been analyzed using finite element method based software ANSYS. In the present work two parameters: thickness to width of plate (T/A) and diameter of hole to width of plate (D/A) have been varied for analysis of stress concentration factor (SCF) and its mitigation. Plates of five different materials have been considered for complete analysis to find out the sensitivity of stress concentration factor. The D/A ratio varied from 0.1 to 0.7 for analysis of SCF and varied from 0.1 to 0.5 for analyzing the mitigation of SCF. 0.01, 0.05 and 0.1 are considered as T/A ratio for all the cases. The results are presented in graphical form and discussed. The mitigation in SCF reported is very encouraging. The SCF is more sensitive to D/A ratio as compared to T/A.

  19. Prognostic factors for specific lower extremity and spinal musculoskeletal injuries identified through medical screening and training load monitoring in professional football (soccer): a systematic review

    Science.gov (United States)

    Sergeant, Jamie C; Parkes, Matthew J; Callaghan, Michael J

    2017-01-01

    Background Medical screening and load monitoring procedures are commonly used in professional football to assess factors perceived to be associated with injury. Objectives To identify prognostic factors (PFs) and models for lower extremity and spinal musculoskeletal injuries in professional/elite football players from medical screening and training load monitoring processes. Methods The MEDLINE, AMED, EMBASE, CINAHL Plus, SPORTDiscus and PubMed electronic bibliographic databases were searched (from inception to January 2017). Prospective and retrospective cohort studies of lower extremity and spinal musculoskeletal injury incidence in professional/elite football players aged between 16 and 40 years were included. The Quality in Prognostic Studies appraisal tool and the modified Grading of Recommendations Assessment, Development and Evaluation synthesis approach was used to assess the quality of the evidence. Results Fourteen studies were included. 16 specific lower extremity injury outcomes were identified. No spinal injury outcomes were identified. Meta-analysis was not possible due to heterogeneity and study quality. All evidence related to PFs and specific lower extremity injury outcomes was of very low to low quality. On the few occasions where multiple studies could be used to compare PFs and outcomes, only two factors demonstrated consensus. A history of previous hamstring injuries (HSI) and increasing age may be prognostic for future HSI in male players. Conclusions The assumed ability of medical screening tests to predict specific musculoskeletal injuries is not supported by the current evidence. Screening procedures should currently be considered as benchmarks of function or performance only. The prognostic value of load monitoring modalities is unknown. PMID:29177074

  20. Personal factors associated with smoking among marginalized and disadvantaged youth in Japan. A strong relationship between smoking and convenience store use.

    Science.gov (United States)

    Watanabe, Isao; Shigeta, Masako; Inoue, Kaoru; Matsui, Daisuke; Ozaki, Etsuko; Kuriyama, Nagato; Ozasa, Kotaro; Yamamoto, Toshiro; Kanamura, Narisato; Watanabe, Yoshiyuki

    2013-12-01

    A national survey in Japan reported that the prevalence of smoking among high school students has sharply decreased in recent years. However, the survey only considered students who attended regular high schools (RHSs), and Japan offers part-time high schools (PHSs) that are often attended by academically and socioeconomically disadvantaged youth. Therefore, we examined the smoking prevalence and smoking-related factors among PHS students. A self-administered questionnaire-based survey was conducted at six PHSs. The subjects included 540 enrolled students aged 15 to 18 years. The questionnaire included items on smoking status, smokers in the family, frequency of convenience store use, lifestyle behaviors, and health awareness. Logistic regression analysis was used to identify factors that were significantly associated with smoking. A total of 45.6 % of students had smoking experience, and 29.3 % were smokers. For males and females, the smoking prevalence was about 3 and 7-12 times higher, respectively, than that reported in the national survey. The factors found to be significantly associated with smoking included having a smoker in the family, experience with drinking alcohol, and using convenience store daily (odds ratio [OR] = 12.5) or sometimes (OR = 3.63). There was a significant dose-response relationship between smoking and convenience store use. The smoking prevalence among PHS students was remarkably higher than that among RHS students. These findings suggest that marginalized and disadvantaged youth should be targeted for tobacco control, and intervention is needed to protect youth from tobacco sales and advertising at convenience stores.

  1. Regional analysis of groundwater phosphate concentrations under acidic sandy soils: Edaphic factors and water table strongly mediate the soil P-groundwater P relation.

    Science.gov (United States)

    Mabilde, Lisa; De Neve, Stefaan; Sleutel, Steven

    2017-12-01

    Historic long-term P application to sandy soils in NW-Europe has resulted in abundant sorption, saturation and eventually leaching of P from soil to the groundwater. Although many studies recognize the control of site-specific factors like soil texture and phosphate saturation degree (PSD), the regional-scaled relevance of effects exerted by single factors controlling P leaching is unclear. Very large observational datasets of soil and groundwater P content are furthermore required to reveal indirect controls of soil traits through mediating soil variables. We explored co-variation of phreatic groundwater orthophosphate (o-P) concentration and soil factors in sandy soils in Flanders, Belgium. Correlation analyses were complemented with an exploratory model derived using 'path analysis'. Data of oxalate-extractable Al, Fe, P and pH KCl , phosphate sorption capacity (PSC) and PSD in three depth layers (0-30, 30-60, 60-90 cm), topsoil SOC, % clay and groundwater depth (fluctuation) were interpolated to predict soil properties on exact locations of a very extensive net of groundwater monitoring wells. The mean PSD was only poorly correlated to groundwater o-P concentration, indicating the overriding control of other factors in the transport of P to the groundwater. A significant (P soil pH and groundwater table depth than by PSD indicates the likely oversimplification of the latter index to measure the long-term potential risk of P leaching. Accounting for controls on leaching not included in PSD via an alternative index, however, seems problematic as in Flanders for example groundwater o-P turned out to be higher in finer textured soils or soils with higher pedogenic Fe content, probably because of their lower pedogenic Al content and higher soil pH. Path analysis of extensive soil and groundwater datasets seems a viable way to identify prime local determinants of soil P leaching and could be further on used for 'ground-truthing' more complex P-migration simulation

  2. <strong>Authenticated hash tablesstrong>

    DEFF Research Database (Denmark)

    Triandopoulos, Nikolaos; Papamanthou, Charalampos; Tamassia, Roberto

    2008-01-01

    Hash tables are fundamental data structures that optimally answer membership queries. Suppose a client stores n elements in a hash table that is outsourced at a remote server so that the client can save space or achieve load balancing. Authenticating the hash table functionality, i.e., verifying...... to a scheme that achieves different trade-offs---namely, constant update time and O(nε/logκε n) query time for fixed ε > 0 and κ > 0. An experimental evaluation of our solution shows very good scalability....

  3. Comparative limb bone loading in the humerus and femur of the tiger salamander: testing the 'mixed-chain' hypothesis for skeletal safety factors.

    Science.gov (United States)

    Kawano, Sandy M; Economy, D Ross; Kennedy, Marian S; Dean, Delphine; Blob, Richard W

    2016-02-01

    Locomotion imposes some of the highest loads upon the skeleton, and diverse bone designs have evolved to withstand these demands. Excessive loads can fatally injure organisms; however, bones have a margin of extra protection, called a 'safety factor' (SF), to accommodate loads that are higher than normal. The extent to which SFs might vary amongst an animal's limb bones is unclear. If the limbs are likened to a chain composed of bones as 'links', then similar SFs might be expected for all limb bones because failure of the system would be determined by the weakest link, and extra protection in other links could waste energetic resources. However, Alexander proposed that a 'mixed-chain' of SFs might be found amongst bones if: (1) their energetic costs differ, (2) some elements face variable demands, or (3) SFs are generally high. To test whether such conditions contribute to diversity in limb bone SFs, we compared the biomechanical properties and locomotor loading of the humerus and femur in the tiger salamander (Ambystoma tigrinum). Despite high SFs in salamanders and similar sizes of the humerus and femur that would suggest similar energetic costs, the humerus had lower bone stresses, higher mechanical hardness and larger SFs. SFs were greatest in the anatomical regions where yield stresses were highest in the humerus and lowest in the femur. Such intraspecific variation between and within bones may relate to their different biomechanical functions, providing insight into the emergence of novel locomotor capabilities during the invasion of land by tetrapods. © 2016. Published by The Company of Biologists Ltd.

  4. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane eqrthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years. 23 refs., 9 tabs

  5. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1986-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane earthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years

  6. USE OF STRONG ACID RESIN PUROLITE C100E FOR REMOVING PERMANENT HARDNESS OF WATER – FACTORS AFFECTING CATIONIC EXCHANGE CAPACITY

    Directory of Open Access Journals (Sweden)

    BOGDAN BANDRABUR

    2013-12-01

    Full Text Available This paper experimentally investigates the performance and capacity of Purolite C100E commercial resin recommended for water softening applications in the food industry. The practical ion exchange capacity and the softening process efficiency are studied in batch mode as a function of the sorption specific process factors. Optimum operation conditions were determined as initial pH 7.1, resin dose 8 g dry resin•L-1, temperature 25 oC, contact time of 360 min, and in those conditions the retention capacity for the Ca2+ ions is 17.18 mg•g-1 that corresponds to a removal efficiency equal to 85.7%.

  7. Nephrotic range proteinuria as a strong risk factor for rapid renal function decline during pre-dialysis phase in type 2 diabetic patients with severely impaired renal function.

    Science.gov (United States)

    Kitai, Yuichiro; Doi, Yohei; Osaki, Keisuke; Sugioka, Sayaka; Koshikawa, Masao; Sugawara, Akira

    2015-12-01

    Proteinuria is an established risk factor for progression of renal disease, including diabetic nephropathy. The predictive power of proteinuria, especially nephrotic range proteinuria, for progressive renal deterioration has been well demonstrated in diabetic patients with normal to relatively preserved renal function. However, little is known about the relationship between severity of proteinuria and renal outcome in pre-dialysis diabetic patients with severely impaired renal function. 125 incident dialysis patients with type 2 diabetes were identified. This study was aimed at retrospectively evaluating the impact of nephrotic range proteinuria (urinary protein-creatinine ratio above 3.5 g/gCr) on renal function decline during the 3 months just prior to dialysis initiation. In total, 103 patients (82.4 %) had nephrotic range proteinuria. The median rate of decline in estimated glomerular filtration rate (eGFR) in this study population was 0.98 (interquartile range 0.51-1.46) ml/min/1.73 m(2) per month. Compared to patients without nephrotic range proteinuria, patients with nephrotic range proteinuria showed significantly faster renal function decline (0.46 [0.24-1.25] versus 1.07 [0.64-1.54] ml/min/1.73 m(2) per month; p = 0.007). After adjusting for gender, age, systolic blood pressure, serum albumin, calcium-phosphorus product, hemoglobin A1c, and use of an angiotensin-converting enzyme inhibitor or an angiotensin II receptor blocker, patients with nephrotic range proteinuria showed a 3.89-fold (95 % CI 1.08-14.5) increased risk for rapid renal function decline defined as a decline in eGFR ≥0.5 ml/min/1.73 m(2) per month. Nephrotic range proteinuria is the predominant renal risk factor in type 2 diabetic patients with severely impaired renal function receiving pre-dialysis care.

  8. Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-β1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Tan, Eng-lai; Selvaratnam, G; Kananathan, R; Sam, Choon-kook

    2006-01-01

    Nasopharyngeal carcinoma (NPC) is a common epithelial neoplasm among the Chinese populations in Southern China and South East Asia. Epstein-Barr virus (EBV) is known to be an important etiologic agent of NPC and the viral gene products are frequently detected in NPC tissues along with elevated antibody titres to the viral proteins (VCA and EA) in a majority of patients. Elevated plasma EBV DNA load is regarded as an important marker for the presence of the disease and for the monitoring of disease progression. However, other serum/plasma parameters such as the levels of certain interleukins and growth factors have also been implicated in NPC. The objectives of the present study are, 1) to investigate the correlations between plasma EBV DNA load and the levels of interleukin (IL)-6, IL-10, TGF-β1 and SCF (steel factor) and 2) to relate these parameters to the stages of NPC and the effect of treatment. A total of 78 untreated NPC patients were enrolled in this study. Of these, 51 were followed-up after treatment. The remaining patients had irregular or were lost to follow-up. Plasma EBV DNA was quantified using real-time quantitative PCR. The levels of plasma interleukins and growth factors were quantified using ELISA. A significant decrease in EBV DNA load was detected in plasma of untreated NPC patients (1669 ± 637 copies/mL; n = 51) following treatment (57 ± 37 copies/mL, p < 0.05); n = 51). Plasma EBV DNA load was shown to be a good prognosticator for disease progression and clinical outcome in five of the follow-up patients. A significant difference in IL-6 levels was noted between the untreated patients (164 ± 37 pg/mL; n = 51) and following treatment (58 ± 16 pg/mL, p < 0.05; n = 51). Positive correlations between EBV DNA load and IL-10 (r(49) = 0.535, p < 0.01), between IL6 and IL-10 (r(49) = 0.474, p < 0.01) and between TGF and SCF (r(49) = 0.464, p < 0.01) were observed in patients following treatment. None of the parameters tested including Ig

  9. Testing strong interaction theories

    International Nuclear Information System (INIS)

    Ellis, J.

    1979-01-01

    The author discusses possible tests of the current theories of the strong interaction, in particular, quantum chromodynamics. High energy e + e - interactions should provide an excellent means of studying the strong force. (W.D.L.)

  10. Three Dimensional Parametric Analyses on Effect of Fibre Orientation for Stress Concentration Factor in Fibrous Composite Cantilever Plate with Central Circular Hole under Transverse Loading

    Directory of Open Access Journals (Sweden)

    Nitin Jain

    2012-10-01

    Full Text Available Normal 0 false false false EN-IN X-NONE X-NONE ABSTRACT: A number of analytical and numerical techniques are available for the two dimensional study of stress concentration around the hole(s in isotropic and composite plates subjected to in-plane or transverse loading conditions. The information on the techniques for three dimensional analyses of stress concentration factor (SCF around the hole in isotropic and composite plates subjected to transverse loading conditions is, however, limited. The present work emphasizes on the effect of fibre orientation (q on the stress concentration factor in fibrous composite plates with central circular hole under transverse static loading condition. The work is carried out for cantilever fibrous composite plates. The effects of thickness -to- width (T/A and diameter-to-width (D/A ratios upon SCF at different fibre orientation are studied. Plates of four different composite materials were considered for hole analysis in order to determine the sensitivity of SCF with elastic constants. Deflections in transverse direction were calculated and analysed. All results are presented in graphical form and discussed. The finite element formulation and its analysis were carried out using ANSYS package.ABSTRAK: Terdapat pelbagai teknik analitikal dan numerical untuk kajian tumpuan tegasan dua dimensi di sekeliling lubang-lubang dalam komposit isotropik dan plat pada satah atau keadaan bebanan melintang. Bagaimanapun, maklumat mengenai kaedah analisis tiga dimensi untuk faktor ketumpatan tegasan (SCF sekitar lubang dalam komposit isotropik dan plat pada keadaan bebanan melintang adalah terhad. Kertas ini menekankan kesan orientasi gentian (q pada faktor tumpuan tegasan dalam komposit plat bergentian dengan lubang berpusat di bawah keadaan bebanan melintang. Kajian ini dilkukan untuk cantilever plat komposit bergentian. Kesan ketebalan terhadap kelebaran plat (T/A dan diameter terhadap kelebaran komposit (D/A dengan SCF

  11. Determinación IN-SITU del factor de potencia y la eficiencia de motores asincrónicos a cargas parciales; Induction motor power factor and efficiency IN-SITU determination under partial loads.

    Directory of Open Access Journals (Sweden)

    Percy Rafael Viego Felipe

    2015-04-01

    Full Text Available Los motores asincrónicos trifásicos no siempre operan a plena carga y por lo tanto, el factor de potencia y la eficiencia se ven afectados. Determinar estos valores a diferentes cargas, es la base para programas ahorro en la industria y los servicios. En este trabajo se presentan procedimientos para la estimación del factor de potencia y la eficiencia a cargas parciales, con una precisión acorde a los propósitos ingenieriles, baja invasividad y sin implicar para el usuario complejidades de equipamiento o de adquisición y procesamiento de datos. Se ofrecen distintas variantes para la estimación del factor de potencia y la eficiencia, según los datos con que se cuente. Se comparan los resultados de los métodos propuestos con la información de catálogos comerciales. Se realiza un análisis con motores de distinta potencia y velocidad, que demuestra que se logra buena precisión para los propósitos señalados. Three phase induction motors are rarely operating at full load and, in consequence, power factor and efficiency are affected. Determining these values for different partial loads is needed for energy saving programs in industrial and service enterprises. In this work, procedures are given for power factor and efficiency estimation at different loads. These procedures are low or not-invasive, have a good precision for engineering purposes, and do not require neither complex equipment nor complicated acquisition and processing data systems Different ways for estimating the before mentioned parameters, depending on the known data, are given. The results of the proposed procedures are compared with those of manufacturer catalogs. A comparative analysis considering motors of different output power and speed is done, and it shows that the results are enough accurate for the established purposes.

  12. HPV-16 viral load in oropharyngeal squamous cell carcinoma using digital PCR.

    Science.gov (United States)

    Antonsson, Annika; Knight, Lani; Panizza, Benedict J; Porceddu, Sandro V; Emmett, Sarah; Whiteman, David C

    2018-05-09

    We did not identify any strong associations between HPV-16 viral load and any of the clinical or lifestyle factors. The epidemiology of oropharyngeal SCC is changing, with an increasing proportion of HPV-positive cases seen in the last decade. It is known that a high viral load is linked to the development of cervical cancer, the relation between viral load and oropharyngeal SCC is less clear. We sought to determine HPV-16 viral load in HPV-positive oropharyngeal SCCs using highly sensitive digital PCR and to identify clinical and lifestyle factors associated with viral load. We analysed 45 HPV-16 positive oropharyngeal SCCs diagnosed between 2013 and 2015. All patients completed a lifestyle questionnaire and clinical data were extracted from medical charts. Viral load was determined using digital PCR assays for HPV-L1 and RNAseP. We found large variations in HPV-16 viral load from 1 to 930 copies per cell (median 34 copies per cell).

  13. Investigation of R-Factor for steel moment frame combined with cold-formed steel structures under different load patterns using pushover analysis

    Directory of Open Access Journals (Sweden)

    Siavash Sadeghi

    2017-08-01

    Full Text Available The use of Lightweight Steel Frames (LSF has grown considerably in recent years all over the world due to its unique advantages such as being cost-effective and light-weight, easy and quick installment. Another application is to use them in order to increase the number of new floors on the existing buildings. But since the behavior of the combined structure is not clear, there is no possibility of increasing new floors with Lightweight Steel Frames. Therefore, through selecting and modeling three buildings of three, five and seven floors with steel moment frames in SAP2000 software and adding one or two new floors using Lightweight Steel Frames (LSF and conducting a non-linear static analysis with three different lateral load pattern, we dealt with the seismic behavior and determined the behavior coefficient of each of the combined structures. The results indicated that the use of cold-formed structures in order to add story do not have a significant impact on R-factor. In addition, R-factor depends on the type of the side loading pattern.

  14. Load and resistance factor design calibration to determine a resistance factor for the modification of the Kansas Department of Transportation-Engineering News Record formula.

    Science.gov (United States)

    2014-02-01

    This report contains the results of a study describing the development of resistance factors for use : with the Kansas Department of Transportation (KDOT) Engineering News Record (ENR) formula for driven : piles. KDOT has verified driven pile resista...

  15. Mixed-mode stress intensity factors for kink cracks with finite kink length loaded in tension and bending: application to dentin and enamel.

    Science.gov (United States)

    Bechtle, Sabine; Fett, Theo; Rizzi, Gabriele; Habelitz, Stefan; Schneider, Gerold A

    2010-05-01

    Fracture toughness resistance curves describe a material's resistance against crack propagation. These curves are often used to characterize biomaterials like bone, nacre or dentin as these materials commonly exhibit a pronounced increase in fracture toughness with crack extension due to co-acting mechanisms such as crack bridging, crack deflection and microcracking. The knowledge of appropriate stress intensity factors which depend on the sample and crack geometry is essential for determining these curves. For the dental biomaterials enamel and dentin it was observed that, under bending and tensile loading, crack propagation occurs under certain constant angles to the initial notch direction during testing procedures used for fracture resistance curve determination. For this special crack geometry (a kink crack of finite length in a finite body) appropriate geometric function solutions are missing. Hence, we present in this study new mixed-mode stress intensity factors for kink cracks with finite kink length within samples of finite dimensions for two loading cases (tension and bending) which were derived from a combination of mixed-mode stress intensity factors of kink cracks with infinitely small kinks and of slant cracks. These results were further applied to determine the fracture resistance curves of enamel and dentin by testing single edge notched bending (SENB) specimens. It was found that kink cracks with finite kink length exhibit identical stress fields to slant cracks as soon as the kink length exceeds 0.15 times the initial straight crack or notch length. The use of stress intensity factor solutions for infinitely small kink cracks for the determination of dentin fracture resistance curves (as was done by other researchers) leads to an overestimation of dentin's fracture resistance of up to 30%. Copyright 2010 Elsevier Ltd. All rights reserved.

  16. Investigation about selecting strong type of melons by using melon paleness factor fusarium oxysporum f.sp.melonis and mutation techniques

    International Nuclear Information System (INIS)

    Kantoglu, Y.; Secer, E.; Kunter, B.; Erzurum, K.; Maden, S.; Yanmaz, R.

    2009-01-01

    Fusarium wilt is a vascular disease of the Cucurbitaceae family, especially in muskmelon (Cucumis melo L.), caused by the soil fungus Fusarium oxysporum f. sp. melonis (FOM). This pathogen persists in the soil for extended periods of time, and the only effective control is the use of resistant varieties. Fusarium oxysporum f. sp. melonis is a very serious disease factor for farmers in Turkey. In this research, we show a method for mass-selection of melon mutants resistant to Fusarium wilt. In vitro selection of resistant cells, which are come from irradiated and non-irradiated explants, is done using culture filtrates of different FOM races. According to our results we determined effective irradiation doses and filtrate treatment dose by Linear Regression Analysis. According to our results 21.75 Gy is effective dose for in vitro Yuva cv. explants to induce mutation and for filtrate treatment 6.73% is the proper dose to select survive calluses and plantlets. We recommended using 10 and 20 Gy gamma ray doses for in vitro melon plantlets to induce mutation by our results. We succeed to regenerate 6% plantlets which were obtained and selected from irradiated plantlets and regenerated in in vitro medias which were include 6.73 % filtrate. Although 16.7% of resistant or tolerant plantlets can continue their viability in greenhouse conditions after disease inoculation treatment, we observed 4 plants had a surviving capability in a limited time. That is very important for breeding cycle and this research can lead to the development of new melon cultivars that will be resistant to Fusarium wilt.

  17. Strong-interaction nonuniversality

    International Nuclear Information System (INIS)

    Volkas, R.R.; Foot, R.; He, X.; Joshi, G.C.

    1989-01-01

    The universal QCD color theory is extended to an SU(3) 1 direct product SU(3) 2 direct product SU(3) 3 gauge theory, where quarks of the ith generation transform as triplets under SU(3)/sub i/ and singlets under the other two factors. The usual color group is then identified with the diagonal subgroup, which remains exact after symmetry breaking. The gauge bosons associated with the 16 broken generators then form two massive octets under ordinary color. The interactions between quarks and these heavy gluonlike particles are explicitly nonuniversal and thus an exploration of their physical implications allows us to shed light on the fundamental issue of strong-interaction universality. Nonuniversality and weak flavor mixing are shown to generate heavy-gluon-induced flavor-changing neutral currents. The phenomenology of these processes is studied, as they provide the major experimental constraint on the extended theory. Three symmetry-breaking scenarios are presented. The first has color breaking occurring at the weak scale, while the second and third divorce the two scales. The third model has the interesting feature of radiatively induced off-diagonal Kobayashi-Maskawa matrix elements

  18. Monte Carlo Method to Study Properties of Acceleration Factor Estimation Based on the Test Results with Varying Load

    Directory of Open Access Journals (Sweden)

    N. D. Tiannikova

    2014-01-01

    Full Text Available G.D. Kartashov has developed a technique to determine the rapid testing results scaling functions to the normal mode. Its feature is preliminary tests of products of one sample including tests using the alternating modes. Standard procedure of preliminary tests (researches is as follows: n groups of products with m elements in each start being tested in normal mode and, after a failure of one of products in the group, the remained products are tested in accelerated mode. In addition to tests in alternating mode, tests in constantly normal mode are conducted as well. The acceleration factor of rapid tests for this type of products, identical to any lots is determined using such testing results of products from the same lot. A drawback of this technique is that tests are to be conducted in alternating mode till the failure of all products. That is not always is possible. To avoid this shortcoming, the Renyi criterion is offered. It allows us to determine scaling functions using the right-censored data thus giving the opportunity to stop testing prior to all failures of products.In this work a statistical modeling of the acceleration factor estimation owing to Renyi statistics minimization is implemented by the Monte-Carlo method. Results of modeling show that the acceleration factor estimation obtained through Renyi statistics minimization is conceivable for rather large n . But for small sample volumes some systematic bias of acceleration factor estimation, which decreases with growth n is observed for both distributions (exponential and Veybull's distributions. Therefore the paper also presents calculation results of correction factors for a case of exponential distribution and Veybull's distribution.

  19. Independent predictive factors for significant liver histological changes in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal alanine aminotransferase level

    Directory of Open Access Journals (Sweden)

    LI Qiang

    2016-07-01

    Full Text Available Objective To investigate the independent predictive factors for significant liver histological changes (SLHCs in patients with HBeAg-positive high-viral-load chronic hepatitis B virus (HBV infection and a normal alanine aminotransferase (ALT level. MethodsA retrospective analysis was performed on the clinical data of 116 previously untreated patients with HBeAg-positive high-viral-load (HBV DNA≥105 copies/ml chronic HBV infection and a normal ALT level (<50 U/L who were hospitalized in Shanghai Public Health Clinical Center Affiliated to Fudan University from June 2013 to August 2015. The definition of SLHCs was inflammation ≥G2 and/or fibrosis≥S2. The t-test or Mann-Whitney U rank sum test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Univariate and multivariate regression analyses were used to determine independent predictive factors for SLHCs. ResultsOf all the 116 patients, 47(40.5% had SLHCs. The multivariate analysis showed that age (OR=2.828, P<0.05, ALT (OR=1.011, P<0.05, and gamma-glutamyl transpeptidase (GGT (OR=1.089, P<0.05 were independent predictors for SLHCs in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level. The patients aged ≤30 years had a significantly lower incidence rate of SLHCs than those aged>30 years (21.6% vs 49.4%, χ2=6.42, P=0.015, the patients with ALT ≤30 U/L had a significantly lower incidence rate of SLHCs than those with 30 U/L<ALT≤50 U/L (17.6% vs 50.0%, χ2=19.86, P<0.001, and the patients with GGT≤40 U/L had a significantly lower incidence rate of SLHCs than those with GGT>40 U/L (28.8% vs 66.7%, χ2=28.63, P<0.001. ConclusionIn patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level, those with an age of>30 years, ALT>30 U/L, and GGT>40 U/L tend to develop SLHCs and need liver biopsy.

  20. Cumulative socioeconomic status risk, allostatic load, and adjustment: a prospective latent profile analysis with contextual and genetic protective factors.

    Science.gov (United States)

    Brody, Gene H; Yu, Tianyi; Chen, Yi-fu; Kogan, Steven M; Evans, Gary W; Beach, Steven R H; Windle, Michael; Simons, Ronald L; Gerrard, Meg; Gibbons, Frederick X; Philibert, Robert A

    2013-05-01

    The health disparities literature has identified a common pattern among middle-aged African Americans that includes high rates of chronic disease along with low rates of psychiatric disorders despite exposure to high levels of cumulative socioeconomic status (SES) risk. The current study was designed to test hypotheses about the developmental precursors to this pattern. Hypotheses were tested with a representative sample of 443 African American youths living in the rural South. Cumulative SES risk and protective processes were assessed at ages 11-13 years; psychological adjustment was assessed at ages 14-18 years; genotyping at the 5-HTTLPR was conducted at age 16 years; and allostatic load (AL) was assessed at age 19 years. A latent profile analysis identified 5 profiles that evinced distinct patterns of SES risk, AL, and psychological adjustment, with 2 relatively large profiles designated as focal profiles: a physical health vulnerability profile characterized by high SES risk/high AL/low adjustment problems, and a resilient profile characterized by high SES risk/low AL/low adjustment problems. The physical health vulnerability profile mirrored the pattern found in the adult health disparities literature. Multinomial logistic regression analyses indicated that carrying an s allele at the 5-HTTLPR and receiving less peer support distinguished the physical health vulnerability profile from the resilient profile. Protective parenting and planful self-regulation distinguished both focal profiles from the other 3 profiles. The results suggest the public health importance of preventive interventions that enhance coping and reduce the effects of stress across childhood and adolescence.

  1. Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut.

    Directory of Open Access Journals (Sweden)

    Vincent Raquin

    2017-12-01

    Full Text Available Dengue virus (DENV causes more human infections than any other mosquito-borne virus. The current lack of antiviral strategies has prompted genome-wide screens for host genes that are required for DENV infectivity. Earlier transcriptomic studies that identified DENV host factors in the primary vector Aedes aegypti used inbred laboratory colonies and/or pools of mosquitoes that erase individual variation. Here, we performed transcriptome sequencing on individual midguts in a field-derived Ae. aegypti population to identify new candidate host factors modulating DENV replication. We analyzed the transcriptomic data using an approach that accounts for individual co-variation between viral RNA load and gene expression. This approach generates a prediction about the agonist or antagonist effect of candidate genes on DENV replication based on the sign of the correlation between gene expression and viral RNA load. Using this method, we identified 39 candidate genes that went undetected by conventional pairwise comparison of gene expression levels between DENV-infected midguts and uninfected controls. Only four candidate genes were detected by both methods, emphasizing their complementarity. We demonstrated the value of our approach by functional validation of a candidate agonist gene encoding a sterol regulatory element-binding protein (SREBP, which was identified by correlation analysis but not by pairwise comparison. We confirmed that SREBP promotes DENV infection in the midgut by RNAi-mediated gene knockdown in vivo. We suggest that our approach for transcriptomic analysis can empower genome-wide screens for potential agonist or antagonist factors by leveraging inter-individual variation in gene expression. More generally, this method is applicable to a wide range of phenotypic traits displaying inter-individual variation.

  2. Identification of the Uncertainties for the Calibration of the Partial Safety Factors for Load in Tidal Turbines

    Directory of Open Access Journals (Sweden)

    Gaizka Zarraonandia Simeón

    2016-03-01

    Full Text Available Tidal energy is nowadays one of the fastest growing types of marine renewable energy. In particular, Horizontal Axis Tidal Turbines (HATTs are the most advanced designs and the most appropriate for standardization. This paper presents a review of actual design criteria focusing on the identification of the uncertainties that technology developers need to address during the design process. Key environmental parameters like turbine inflow conditions or predictions of extreme values are still grey areas due to the lack of site measurements and the uncertainty in metocean model predictions. A comparison of turbulence intensity characterization using different tools and at different points in time shows the uncertainty in the prediction of this parameter. Numerical models of HATTs are still quite uncertain, often dependent on experience of the people running them. In the reliability-based calibration of partial safety factors, the uncertainties need to be reflected on the limit state formulation. This paper analyses the different types of uncertainties present in the limit state equation. These uncertainties are assessed in terms of stochastic variables in the limit state equation. In some cases, advantage can be taken from the experience from offshore wind and oil and gas industries. Tidal turbines have a mixture of the uncertainties present in both industries with regard to partial safety factor calibration.

  3. Abortion: Strong's counterexamples fail

    DEFF Research Database (Denmark)

    Di Nucci, Ezio

    2009-01-01

    This paper shows that the counterexamples proposed by Strong in 2008 in the Journal of Medical Ethics to Marquis's argument against abortion fail. Strong's basic idea is that there are cases--for example, terminally ill patients--where killing an adult human being is prima facie seriously morally...

  4. Strong Langmuir turbulence

    International Nuclear Information System (INIS)

    Goldman, M.V.

    1984-01-01

    After a brief discussion of beam-excited Langmuir turbulence in the solar wind, we explain the criteria for wave-particle, three-wave and strong turbulence interactions. We then present the results of a numerical integration of the Zakharov equations, which describe the strong turbulence saturation of a weak (low-density) high energy, bump-on-tail beam instability. (author)

  5. Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

    Directory of Open Access Journals (Sweden)

    Ai C

    2017-10-01

    Full Text Available Chengchong Ai, Dandan Sheng, Jun Chen, Jiangyu Cai, Siheng Wang, Jia Jiang, Shiyi Chen Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract: Ultra-high-molecular-weight polyethylene (UHMWPE has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF was loaded on the surface of materials, the loading was performed by silk fibroin (SF coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM and attenuated total reflectance (ATR-Fourier transform infrared (FTIR and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8 assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF

  6. Interaction of Mechanical Load with Growth Hormone (GH) and Insulin-Like Growth Factor I (IGF-I) on Slow-Twitch Skeletal Muscle and Bone

    Science.gov (United States)

    Linderman, Jon K.; Gosselink, Kristin L.; Wang, Tommy J.; Mukku, Venkat R.; Grindeland, Richard E.

    1994-01-01

    Exogenous humoral growth factors, combined with increased mechanical loading, reportedly induce hypertrophy of fast-, but not slow-twitch skeletal muscles, and have little effect in attenuating atrophy of slow-twitch muscle associated with exposure to microgravity in animals with intact neuroendocrine systems. These observations suggest that anabolic adjuvants and muscle tension do not interact to stimulate growth or maintenance of slow-twitch skeletal muscle. The purpose of the present study was to determine whether a chronic increase in mechanical loading (synergistic ablation) or hindlimb unweighting (hindlimb suspension) interact with exogenous GH and IGF-I (Genentech, So San Francisco, CA) in the slow-twitch soleus muscles of female rats (approx. 250 g). Bilateral ablation of the plantaris and gastrocnemius muscles induced 38% and 40% increases in the absolute (mg/pair) and relative (mg/100 g body weight) weights of the soleus, respectively (p less than or = 0.05), in ambulatory rats. GH and IGF-I interacted with chronic loading to increase absolute soleus mass an additional 20% (p less than or = 0.05), and mixed and myofibrillar protein contents an additional 12% and 7%, respectively (NS). In contrast, hindlimb suspension (HLS) resulted in 20% and 18% decreases in the absolute and relative weights of the soleus, respectively (p less than or = 0.05); GH and IGF-I did not spare loss of soleus mass or protein content in HLS rats. HLS decreased tibial plate thickness approx. 11% (p less than or = 0.05), but not weights of the tibia or femus. GH and IGF-I increased tibial plate thickness approx. 30% (p less than or = 0.05), in ambulatory and HLS rats, and increased femur and tibial weights 12% (p less than or = 0.05) and 8% (NS), respectively, in ambulatory rats, but had no effect in HLS rats. Results of the present investigation suggest that GH and IGF-I can stimulate hypertrophy of slow-twitch skeletal muscle when chronically overloaded, but can also stimulate

  7. Ultrasound-targeted stromal cell-derived factor-1-loaded microbubble destruction promotes mesenchymal stem cell homing to kidneys in diabetic nephropathy rats

    Directory of Open Access Journals (Sweden)

    Wu S

    2014-12-01

    Full Text Available Shengzheng Wu,1 Lu Li,1 Gong Wang,1 Weiwei Shen,2 Yali Xu,1 Zheng Liu,1 Zhongxiong Zhuo,1 Hongmei Xia,1 Yunhua Gao,1 Kaibin Tan1 1Department of Ultrasound, 2Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China Abstract: Mesenchymal stem cell (MSC therapy has been considered a promising strategy to cure diabetic nephropathy (DN. However, insufficient MSCs can settle in injured kidneys, which constitute one of the major barriers to the effective implementation of MSC therapy. Stromal cell-derived factor-1 (SDF-1 plays a vital role in MSC migration and involves activation, mobilization, homing, and retention, which are presumably related to the poor homing in DN therapy. Ultrasound-targeted microbubble destruction has become one of the most promising strategies for the targeted delivery of drugs and genes. To improve MSC homing to DN kidneys, we present a strategy to increase SDF-1 via ultrasound-targeted microbubble destruction. In this study, we developed SDF-1-loaded microbubbles (MBSDF-1 via covalent conjugation. The characterization and bioactivity of MBSDF-1 were assessed in vitro. Target release in the targeted kidneys was triggered with diagnostic ultrasound in combination with MBSDF-1. The related bioeffects were also elucidated. Early DN was induced in rats with streptozotocin. Green fluorescent protein-labeled MSCs were transplanted intravenously following the target release of SDF-1 in the kidneys of normal and DN rats. The homing efficacy was assessed by detecting the implanted exogenous MSCs at 24 hours. The in vitro results showed an impressive SDF-1 loading efficacy of 79% and a loading content of 15.8 µg/mL. MBSDF-1 remained bioactive as a chemoattractant. In the in vivo study, SDF-1 was successfully released in the targeted kidneys. The homing efficacy of MSCs to DN kidneys after the target release of SDF-1 was remarkably ameliorated at 24 hours compared with

  8. The role of the demand-duration curve in the evaluation of power station installation policies. Remarks on its effects on stations' utilization, generating capacity, load factor history and consumptions

    International Nuclear Information System (INIS)

    Graziani, G.; Maineri, M.; Zanantoni, C.

    1976-12-01

    The role of the load-duration curve in determining the installation policy for an electric power system, is examined. The effect of the priority order for the allocation of the power stations in the load-diagram is also discussed: in the model used here (program TOTEM) this priority is given as a function of type and age of the station. The significance of the load factor history for a power station as a function of its age is also discussed. It is suggested that such a curve be deduced as a result of strategy calculations made with TOTEM rather than assumping it as input data

  9. Calibration procedures for improved accuracy of wind turbine blade load measurement

    Energy Technology Data Exchange (ETDEWEB)

    Dahlberg, J.Aa. [Aeronautical Research Inst. of Sweden, Bromma (Sweden); Johansson, Hjalmar [Teknikgruppen AB, Sollentuna (Sweden)

    1996-12-01

    External loads acting on wind turbine blades are mainly transferred via the hub to the rest of the structure. It is therefore a normal approach to measure the loads acting on the turbine by load measurements in the blade roots. The load measurement is often accomplished by measurements of strain on the surface of the blade or the hub. The strain signals are converted to loads by applying calibration factors to the measurements. This paper deals with difficulties associated with load measurements on two different wind turbines; one with strain gauges applied to a steel hub where a linear stress-load relationship is expected and the other with strain gauges applied to the GFRP blade close to the bearings where strong non-linearity`s and temperature effects are expected. This paper suggests calibration methods to overcome these problems. 2 refs, 11 figs

  10. An electricity price model with consideration to load and gas price effects.

    Science.gov (United States)

    Huang, Min-xiang; Tao, Xiao-hu; Han, Zhen-xiang

    2003-01-01

    Some characteristics of the electricity load and prices are studied, and the relationship between electricity prices and gas (fuel) prices is analyzed in this paper. Because electricity prices are strongly dependent on load and gas prices, the authors constructed a model for electricity prices based on the effects of these two factors; and used the Geometric Mean Reversion Brownian Motion (GMRBM) model to describe the electricity load process, and a Geometric Brownian Motion(GBM) model to describe the gas prices; deduced the price stochastic process model based on the above load model and gas price model. This paper also presents methods for parameters estimation, and proposes some methods to solve the model.

  11. Strong intrinsic motivation

    OpenAIRE

    Dessi, Roberta; Rustichini, Aldo

    2015-01-01

    A large literature in psychology, and more recently in economics, has argued that monetary rewards can reduce intrinsic motivation. We investigate whether the negative impact persists when intrinsic motivation is strong, and test this hypothesis experimentally focusing on the motivation to undertake interesting and challenging tasks, informative about individual ability. We find that this type of task can generate strong intrinsic motivation, that is impervious to the effect of monetary incen...

  12. Bitcoin Meets Strong Consistency

    OpenAIRE

    Decker, Christian; Seidel, Jochen; Wattenhofer, Roger

    2014-01-01

    The Bitcoin system only provides eventual consistency. For everyday life, the time to confirm a Bitcoin transaction is prohibitively slow. In this paper we propose a new system, built on the Bitcoin blockchain, which enables strong consistency. Our system, PeerCensus, acts as a certification authority, manages peer identities in a peer-to-peer network, and ultimately enhances Bitcoin and similar systems with strong consistency. Our extensive analysis shows that PeerCensus is in a secure state...

  13. Strong gravity and supersymmetry

    International Nuclear Information System (INIS)

    Chamseddine, Ali H.; Salam, A.; Strathdee, J.

    1977-11-01

    A supersymmetric theory is constructed for a strong f plus a weak g graviton, together with their accompanying massive gravitinos, by gaugin the gradel 0Sp(2,2,1)x 0Sp(2,2,1) structure. The mixing term between f and g fields, which makes the strong graviton massive, can be introduced through a spontaneous symmetry-breaking mechanism implemented in this note by constructing a non-linear realization of the symmetry group

  14. Strongly interacting Fermi gases

    Directory of Open Access Journals (Sweden)

    Bakr W.

    2013-08-01

    Full Text Available Strongly interacting gases of ultracold fermions have become an amazingly rich test-bed for many-body theories of fermionic matter. Here we present our recent experiments on these systems. Firstly, we discuss high-precision measurements on the thermodynamics of a strongly interacting Fermi gas across the superfluid transition. The onset of superfluidity is directly observed in the compressibility, the chemical potential, the entropy, and the heat capacity. Our measurements provide benchmarks for current many-body theories on strongly interacting fermions. Secondly, we have studied the evolution of fermion pairing from three to two dimensions in these gases, relating to the physics of layered superconductors. In the presence of p-wave interactions, Fermi gases are predicted to display toplogical superfluidity carrying Majorana edge states. Two possible avenues in this direction are discussed, our creation and direct observation of spin-orbit coupling in Fermi gases and the creation of fermionic molecules of 23Na 40K that will feature strong dipolar interactions in their absolute ground state.

  15. A strong comeback

    International Nuclear Information System (INIS)

    Marier, D.

    1992-01-01

    This article presents the results of a financial rankings survey which show a strong economic activity in the independent energy industry. The topics of the article include advisor turnover, overseas banks, and the increase in public offerings. The article identifies the top project finance investors for new projects and restructurings and rankings for lenders

  16. Load theory behind the wheel; perceptual and cognitive load effects.

    Science.gov (United States)

    Murphy, Gillian; Greene, Ciara M

    2017-09-01

    Perceptual Load Theory has been proposed as a resolution to the longstanding early versus late selection debate in cognitive psychology. There is much evidence in support of Load Theory but very few applied studies, despite the potential for the model to shed light on everyday attention and distraction. Using a driving simulator, the effect of perceptual and cognitive load on drivers' visual search was assessed. The findings were largely in line with Load Theory, with reduced distractor processing under high perceptual load, but increased distractor processing under high cognitive load. The effect of load on driving behaviour was also analysed, with significant differences in driving behaviour under perceptual and cognitive load. In addition, the effect of perceptual load on drivers' levels of awareness was investigated. High perceptual load significantly increased inattentional blindness and deafness, for stimuli that were both relevant and irrelevant to driving. High perceptual load also increased RTs to hazards. The current study helps to advance Load Theory by illustrating its usefulness outside of traditional paradigms. There are also applied implications for driver safety and roadway design, as the current study suggests that perceptual and cognitive load are important factors in driver attention. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  17. Common long-range dependence in a panel of hourly Nord Pool electricity prices and loads

    DEFF Research Database (Denmark)

    Ergemen, Yunus Emre; Haldrup, Niels; Rodríguez-Caballero, Carlos Vladimir

    to strong seasonal periodicity, and along the cross-sectional dimension, i.e. the hours of the day, there is a strong dependence which necessarily has to be accounted for in order to avoid spurious inference when focusing on the time series dependence alone. The long-range dependence is modelled in terms...... of a fractionally integrated panel data model and it is shown that both prices and loads consist of common factors with long memory and with loadings that vary considerably during the day. Due to the competitiveness of the Nordic power market the aggregate supply curve approximates well the marginal costs...... data approaches to analyse the time series and the cross-sectional dependence of hourly Nord Pool electricity spot prices and loads for the period 2000-2013. Hourly electricity prices and loads data are characterized by strong serial long-range dependence in the time series dimension in addition...

  18. Beam loading

    OpenAIRE

    Boussard, Daniel

    1987-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superco...

  19. The effect of perceptual load on tactile spatial attention: Evidence from event-related potentials.

    Science.gov (United States)

    Gherri, Elena; Berreby, Fiona

    2017-10-15

    To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modulations by load are sensitive to the availability of visual information, the High and Low load tasks were carried out under both illuminated and darkness conditions. ERPs to cued and uncued non-targets were compared as a function of task (High vs. Low load) and illumination condition (Light vs. Darkness). Results revealed that the locus of tactile spatial attention was determined by a complex interaction between perceptual load and illumination conditions during sensory-specific stages of processing. In the Darkness, earlier effects of attention were present in the High load than in the Low load task, while no difference between tasks emerged in the Light. By contrast, increased load was associated with stronger attention effects during later post-perceptual processing stages regardless of illumination conditions. These findings demonstrate that ERP correlates of tactile spatial attention are strongly affected by the perceptual load of the target/non-target discrimination. However, differences between illumination conditions show that the impact of load on tactile attention depends on the presence of visual information. Perceptual load is one of the many factors that contribute to determine the effects of spatial selectivity in touch. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    Energy Technology Data Exchange (ETDEWEB)

    Manning, Karessa L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dolislager, Fredrick G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bellamy, Michael B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-11-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  1. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    International Nuclear Information System (INIS)

    Manning, Karessa L.; Dolislager, Fredrick G.; Bellamy, Michael B.

    2016-01-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  2. Data on respiratory variables in critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+

    Directory of Open Access Journals (Sweden)

    Dimitris Georgopoulos

    2016-09-01

    Full Text Available The data show respiratory variables in 108 critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+ after at least 36 h on passive mechanical ventilation. PAV+ was continued for 48 h until the patients met pre-defined criteria either for switching to controlled modes or for breathing without ventilator assistance. Data during passive mechanical ventilation and during PAV+ are reported. Data are acquired from the whole population, as well as from patients with and without acute respiratory distress syndrome. The reported variables are tidal volume, driving pressure (ΔP, the difference between static end-inspiratory plateau pressure and positive end-expiratory airway pressure, respiratory system compliance and resistance, and arterial blood gasses. The data are supplemental to our original research article, which described individual ΔP in these patients and examined how it related to ΔP when the same patients were ventilated with passive mechanical ventilation using the currently accepted lung-protective strategy “Driving pressure during assisted mechanical ventilation. Is it controlled by patient brain?” [1]. Keywords: Tidal volume, Compliance, Driving pressure

  3. Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells

    International Nuclear Information System (INIS)

    Oka, Yasuyoshi; Suzuki, Keiji; Yamauchi, Motohiro; Mitsutake, Norisato; Yamashita, Shunichi

    2011-01-01

    Highlights: → NIPBL is recruited to DSBs. → Localization of NIPBL to DSBs is regulated by MDC1 and RNF168. → HP1γ is required for NIPBL accumulation at DSBs. -- Abstract: The cohesin loading factor NIPBL is required for cohesin to associate with chromosomes and plays a role in DNA double-strand break (DSB) repair. Although the NIPBL homolog Scc2 is recruited to an enzymatically generated DSB and promotes cohesin-dependent DSB repair in yeast, the mechanism of the recruitment remains poorly understood. Here we show that the human NIPBL is recruited to the sites of DNA damage generated by micro-irradiation as well as to the sites of DSBs induced by homing endonuclease, I-PpoI. The recruitment of NIPBL was impaired by RNAi-mediated knockdown of MDC1 or RNF168, both of which also accumulate at DSBs. We also show that the recruitment of NIPBL to the sites of DNA damage is mediated by its C-terminal region containing HEAT repeats and Heterochromatin protein 1 (HP1) interacting motif. Furthermore, NIPBL accumulation at damaged sites was also compromised by HP1γ depletion. Taken together, our study reveals that human NIPBL is a novel protein recruited to DSB sites, and the recruitment is controlled by MDC1, RNF168 and HP1γ.

  4. Understanding the synergistic effect and the main factors influencing the enzymatic hydrolyzability of corn stover at low enzyme loading by hydrothermal and/or ultrafine grinding pretreatment.

    Science.gov (United States)

    Zhang, Haiyan; Li, Junbao; Huang, Guangqun; Yang, Zengling; Han, Lujia

    2018-05-26

    A thorough assessment of the microstructural changes and synergistic effects of hydrothermal and/or ultrafine grinding pretreatment on the subsequent enzymatic hydrolysis of corn stover was performed in this study. The mechanism of pretreatment was elucidated by characterizing the particle size, specific surface area (SSA), pore volume (PV), average pore size, cellulose crystallinity (CrI) and surface morphology of the pretreated samples. In addition, the underlying relationships between the structural parameters and final glucose yields were elucidated, and the relative significance of the factors influencing enzymatic hydrolyzability were assessed by principal component analysis (PCA). Hydrothermal pretreatment at a lower temperature (170 °C) combined with ultrafine grinding achieved a high glucose yield (80.36%) at a low enzyme loading (5 filter paper unit (FPU)/g substrate) which is favorable. The relative significance of structural parameters in enzymatic hydrolyzability was SSA > PV > average pore size > CrI/cellulose > particle size. PV and SSA exhibited logarithmic correlations with the final enzymatic hydrolysis yield. Copyright © 2018 Elsevier Ltd. All rights reserved.

  5. Strong Electroweak Symmetry Breaking

    CERN Document Server

    Grinstein, Benjamin

    2011-01-01

    Models of spontaneous breaking of electroweak symmetry by a strong interaction do not have fine tuning/hierarchy problem. They are conceptually elegant and use the only mechanism of spontaneous breaking of a gauge symmetry that is known to occur in nature. The simplest model, minimal technicolor with extended technicolor interactions, is appealing because one can calculate by scaling up from QCD. But it is ruled out on many counts: inappropriately low quark and lepton masses (or excessive FCNC), bad electroweak data fits, light scalar and vector states, etc. However, nature may not choose the minimal model and then we are stuck: except possibly through lattice simulations, we are unable to compute and test the models. In the LHC era it therefore makes sense to abandon specific models (of strong EW breaking) and concentrate on generic features that may indicate discovery. The Technicolor Straw Man is not a model but a parametrized search strategy inspired by a remarkable generic feature of walking technicolor,...

  6. Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1.

    Science.gov (United States)

    Wang, Cailian; Zhang, Haijun; Chen, Yan; Shi, Fangfang; Chen, Baoan

    2012-01-01

    E26 transformation-specific sequence-1 (ETS1) transcription factor plays important roles in both carcinogenesis and the progression of a wide range of malignancies. Aberrant ETS1 expression correlates with aggressive tumor behavior and a poorer prognosis in patients with various malignancies. The aim of the current study was to evaluate the efficacy of a drug delivery system utilizing gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles (GA-MNP-Fe(3)O(4)) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer cells. The effects caused by GA-MNP-Fe(3)O(4) on the proliferation of Panc-1 pancreatic cancer cells were evaluated using a MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay while inhibition of tumor cell migration was investigated in a scratch assay. The expressions of ETS1, cyclin D1, urokinase-type plasminogen activator (u-PA), and VEGF (vascular endothelial growth factor) were examined by Western blot to elucidate the possible mechanisms involved. In Panc-1 pancreatic cancer cells, we observed that application of GA-MNP-Fe(3)O(4) was able to suppress cancer cell proliferation and prevent cells from migrating effectively. After treatment, Panc-1 pancreatic cancer cells showed significantly decreased expression of ETS1, as well as its downstream target genes for cyclin D1, u-PA, and VEGF. Our novel finding reaffirmed the significance of ETS1 in the treatment of pancreatic cancer, and application of GA-MNP-Fe(3)O(4) nanoparticles targeting ETS1 should be considered as a promising contribution for better pancreatic cancer care.

  7. Plasmons in strong superconductors

    International Nuclear Information System (INIS)

    Baldo, M.; Ducoin, C.

    2011-01-01

    We present a study of the possible plasmon excitations that can occur in systems where strong superconductivity is present. In these systems the plasmon energy is comparable to or smaller than the pairing gap. As a prototype of these systems we consider the proton component of Neutron Star matter just below the crust when electron screening is not taken into account. For the realistic case we consider in detail the different aspects of the elementary excitations when the proton, electron components are considered within the Random-Phase Approximation generalized to the superfluid case, while the influence of the neutron component is considered only at qualitative level. Electron screening plays a major role in modifying the proton spectrum and spectral function. At the same time the electron plasmon is strongly modified and damped by the indirect coupling with the superfluid proton component, even at moderately low values of the gap. The excitation spectrum shows the interplay of the different components and their relevance for each excitation modes. The results are relevant for neutrino physics and thermodynamical processes in neutron stars. If electron screening is neglected, the spectral properties of the proton component show some resemblance with the physical situation in high-T c superconductors, and we briefly discuss similarities and differences in this connection. In a general prospect, the results of the study emphasize the role of Coulomb interaction in strong superconductors.

  8. Two Nucleolar Proteins, GDP1 and OLI2, Function As Ribosome Biogenesis Factors and Are Preferentially Involved in Promotion of Leaf Cell Proliferation without Strongly Affecting Leaf Adaxial–Abaxial Patterning in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Koji Kojima

    2018-01-01

    Full Text Available Leaf abaxial–adaxial patterning is dependent on the mutual repression of leaf polarity genes expressed either adaxially or abaxially. In Arabidopsis thaliana, this process is strongly affected by mutations in ribosomal protein genes and in ribosome biogenesis genes in a sensitized genetic background, such as asymmetric leaves2 (as2. Most ribosome-related mutants by themselves do not show leaf abaxialization, and one of their typical phenotypes is the formation of pointed rather than rounded leaves. In this study, we characterized two ribosome-related mutants to understand how ribosome biogenesis is linked to several aspects of leaf development. Previously, we isolated oligocellula2 (oli2 which exhibits the pointed-leaf phenotype and has a cell proliferation defect. OLI2 encodes a homolog of Nop2 in Saccharomyces cerevisiae, a ribosome biogenesis factor involved in pre-60S subunit maturation. In this study, we found another pointed-leaf mutant that carries a mutation in a gene encoding an uncharacterized protein with a G-patch domain. Similar to oli2, this mutant, named g-patch domain protein1 (gdp1, has a reduced number of leaf cells. In addition, gdp1 oli2 double mutants showed a strong genetic interaction such that they synergistically impaired cell proliferation in leaves and produced markedly larger cells. On the other hand, they showed additive phenotypes when combined with several known ribosomal protein mutants. Furthermore, these mutants have a defect in pre-rRNA processing. GDP1 and OLI2 are strongly expressed in tissues with high cell proliferation activity, and GDP1-GFP and GFP-OLI2 are localized in the nucleolus. These results suggest that OLI2 and GDP1 are involved in ribosome biogenesis. We then examined the effects of gdp1 and oli2 on adaxial–abaxial patterning by crossing them with as2. Interestingly, neither gdp1 nor oli2 strongly enhanced the leaf polarity defect of as2. Similar results were obtained with as2 gdp1 oli2

  9. Strongly intensive quantities

    International Nuclear Information System (INIS)

    Gorenstein, M. I.; Gazdzicki, M.

    2011-01-01

    Analysis of fluctuations of hadron production properties in collisions of relativistic particles profits from use of measurable intensive quantities which are independent of system size variations. The first family of such quantities was proposed in 1992; another is introduced in this paper. Furthermore we present a proof of independence of volume fluctuations for quantities from both families within the framework of the grand canonical ensemble. These quantities are referred to as strongly intensive ones. Influence of conservation laws and resonance decays is also discussed.

  10. Strong-coupling approximations

    International Nuclear Information System (INIS)

    Abbott, R.B.

    1984-03-01

    Standard path-integral techniques such as instanton calculations give good answers for weak-coupling problems, but become unreliable for strong-coupling. Here we consider a method of replacing the original potential by a suitably chosen harmonic oscillator potential. Physically this is motivated by the fact that potential barriers below the level of the ground-state energy of a quantum-mechanical system have little effect. Numerically, results are good, both for quantum-mechanical problems and for massive phi 4 field theory in 1 + 1 dimensions. 9 references, 6 figures

  11. Position-Dependent Dynamics Explain Pore-Averaged Diffusion in Strongly Attractive Adsorptive Systems.

    Science.gov (United States)

    Krekelberg, William P; Siderius, Daniel W; Shen, Vincent K; Truskett, Thomas M; Errington, Jeffrey R

    2017-12-12

    Using molecular simulations, we investigate the relationship between the pore-averaged and position-dependent self-diffusivity of a fluid adsorbed in a strongly attractive pore as a function of loading. Previous work (Krekelberg, W. P.; Siderius, D. W.; Shen, V. K.; Truskett, T. M.; Errington, J. R. Connection between thermodynamics and dynamics of simple fluids in highly attractive pores. Langmuir 2013, 29, 14527-14535, doi: 10.1021/la4037327) established that pore-averaged self-diffusivity in the multilayer adsorption regime, where the fluid exhibits a dense film at the pore surface and a lower density interior pore region, is nearly constant as a function of loading. Here we show that this puzzling behavior can be understood in terms of how loading affects the fraction of particles that reside in the film and interior pore regions as well as their distinct dynamics. Specifically, the insensitivity of pore-averaged diffusivity to loading arises from the approximate cancellation of two factors: an increase in the fraction of particles in the higher diffusivity interior pore region with loading and a corresponding decrease in the particle diffusivity in that region. We also find that the position-dependent self-diffusivities scale with the position-dependent density. We present a model for predicting the pore-average self-diffusivity based on the position-dependent self-diffusivity, which captures the unusual characteristics of pore-averaged self-diffusivity in strongly attractive pores over several orders of magnitude.

  12. Strong versions of Bell's theorem

    International Nuclear Information System (INIS)

    Stapp, H.P.

    1994-01-01

    Technical aspects of a recently constructed strong version of Bell's theorem are discussed. The theorem assumes neither hidden variables nor factorization, and neither determinism nor counterfactual definiteness. It deals directly with logical connections. Hence its relationship with modal logic needs to be described. It is shown that the proof can be embedded in an orthodox modal logic, and hence its compatibility with modal logic assured, but that this embedding weakens the theorem by introducing as added assumptions the conventionalities of the particular modal logic that is adopted. This weakening is avoided in the recent proof by using directly the set-theoretic conditions entailed by the locality assumption

  13. Post-load hyperglycaemia and diagnostic criteria for diabetes

    Institute of Scientific and Technical Information of China (English)

    Qing Qiao

    2008-01-01

    The evolution of 2 h post-load glucose tolerance test for diagnosis of diabetes and its clinical implication was reviewed and discussed.Post-load hyperglycemia is a risk factor for both micro-and macro-vascular diseases.According to its relationship with retinopathy,the current cut-off values for diabetes was defined since 1979.Recently,strong evidence has shown that post-load hyperglycemia is also an important risk factor for cardiovascular disease(CVD),the relation is linear and no a threshold was found.There are large discrepancies between fasting and 2 h glucose criteria in the classification of diabetes and impaired glucose tolerance(IGT)/impaired fasting glucose(IFG).For early diagnosis and intervention administrating a 2 h OGTT to suspect individuals is necessary.

  14. Beam loading

    CERN Document Server

    Gamp, Alexander

    2013-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superconducting cavities are also given. Finally, a dedicated phase loop for damping synchrotron oscillations is discussed.

  15. Beam loading

    International Nuclear Information System (INIS)

    Gamp, Alexander

    2013-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superconducting cavities are also given. Finally, a dedicated phase loop for damping synchrotron oscillations is discussed. (author)

  16. Strongly disordered superconductors

    International Nuclear Information System (INIS)

    Muttalib, K.A.

    1982-01-01

    We examine some universal effects of strong non-magnetic disorder on the electron-phonon and electron-electron interactions in a superconductor. In particular we explicitly take into account the effect of slow diffusion of electrons in a disordered medium by working in an exact impurity eigenstate representation. We find that the normal diffusion of electrons characterized by a constant diffusion coefficient does not lead to any significant correction to the electron-phonon or the effective electron-electron interactions in a superconductor. We then consider sufficiently strong disorder where Anderson localization of electrons becomes important and determine the effect of localization on the electron-electron interactions. We find that due to localization, the diffusion of electrons becomes anomalous in the sense that the diffusion coefficient becomes scale dependent. This results in an increase in the effective electron-electron interaction with increasing disorder. We propose that this provides a natural explanation for the unusual sensitivity of the transition temperature T/sub c/ of the high T/sub c/ superconductors (T/sub c/ > 10 0 K) to damage effects

  17. Strong Coupling Holography

    CERN Document Server

    Dvali, Gia

    2009-01-01

    We show that whenever a 4-dimensional theory with N particle species emerges as a consistent low energy description of a 3-brane embedded in an asymptotically-flat (4+d)-dimensional space, the holographic scale of high-dimensional gravity sets the strong coupling scale of the 4D theory. This connection persists in the limit in which gravity can be consistently decoupled. We demonstrate this effect for orbifold planes, as well as for the solitonic branes and string theoretic D-branes. In all cases the emergence of a 4D strong coupling scale from bulk holography is a persistent phenomenon. The effect turns out to be insensitive even to such extreme deformations of the brane action that seemingly shield 4D theory from the bulk gravity effects. A well understood example of such deformation is given by large 4D Einstein term in the 3-brane action, which is known to suppress the strength of 5D gravity at short distances and change the 5D Newton's law into the four-dimensional one. Nevertheless, we observe that the ...

  18. Peak load-impulse characterization of critical pulse loads in structural dynamics

    International Nuclear Information System (INIS)

    Abrahamson, G.R.; Lindberg, H.E.

    1975-01-01

    In presenting the characterization scheme, some general features are described first. A detailed analysis is given for the rigid-plastic system of one degree of freedom to illustrate the calculation of critical load curves in terms of peak load and impulse. This is followed by the presentation of critical load curves for uniformly loaded rigid-plastic beams and plates and for dynamic buckling of cylindrical shells under uniform lateral loads. The peak load-impulse characterization of critical pulse loads is compared with the dynamic load factor characterization, and some aspects of the history of the peak load-pulse scheme are presented. (orig./HP) [de

  19. Load sensor

    NARCIS (Netherlands)

    Van den Ende, D.; Almeida, P.M.R.; Dingemans, T.J.; Van der Zwaag, S.

    2007-01-01

    The invention relates to a load sensor comprising a polymer matrix and a piezo-ceramic material such as PZT, em not bedded in the polymer matrix, which together form a compos not ite, wherein the polymer matrix is a liquid crystalline resin, and wherein the piezo-ceramic material is a PZT powder

  20. Carbohydrate Loading.

    Science.gov (United States)

    Csernus, Marilyn

    Carbohydrate loading is a frequently used technique to improve performance by altering an athlete's diet. The objective is to increase glycogen stored in muscles for use in prolonged strenuous exercise. For two to three days, the athlete consumes a diet that is low in carbohydrates and high in fat and protein while continuing to exercise and…

  1. On strongly condensing operators

    Czech Academy of Sciences Publication Activity Database

    Erzakova, N.A.; Väth, Martin

    2017-01-01

    Roč. 196, č. 1 (2017), s. 309-323 ISSN 0373-3114 Institutional support: RVO:67985840 Keywords : asymptotic derivative * compactness * Fréchet derivative Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 0.864, year: 2016 http://link.springer.com/article/10.1007%2Fs10231-016-0573-8

  2. Strong Coupling Continuum QCD

    International Nuclear Information System (INIS)

    Pennington, Michael

    2011-01-01

    The Schwinger-Dyson, Bethe-Salpeter system of equations are the link between coloured quarks and gluons, and colourless hadrons and their properties. This talk reviews some aspects of these studies from the infrared behavior of ghosts to the prediction of electromagnetic form-factors.

  3. LIGO: The strong belief

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Twenty years of designing, building and testing a number of innovative technologies, with the strong belief that the endeavour would lead to a historic breakthrough. The Bulletin publishes an abstract of the Courier’s interview with Barry Barish, one of the founding fathers of LIGO.   The plots show the signals of gravitational waves detected by the twin LIGO observatories at Livingston, Louisiana, and Hanford, Washington. (Image: Caltech/MIT/LIGO Lab) On 11 February, the Laser Interferometer Gravitational-Wave Observatory (LIGO) and Virgo collaborations published a historic paper in which they showed a gravitational signal emitted by the merger of two black holes. These results come after 20 years of hard work by a large collaboration of scientists operating the two LIGO observatories in the US. Barry Barish, Linde Professor of Physics, Emeritus at the California Institute of Technology and former Director of the Global Design Effort for the Internat...

  4. Strongly interacting Higgs bosons

    International Nuclear Information System (INIS)

    Appelquist, T.; Bernard, C.

    1980-01-01

    The sensitivity of present-energy weak interactions to a strongly interacting heavy-Higgs-boson sector is discussed. The gauged nonlinear sigma model, which is the limit of the linear model as the Higgs-boson mass goes to infinity, is used to organize and catalogue all possible heavy-Higgs-boson effects. As long as the SU(2)/sub L/ x SU(2)/sub R/ symmetry of the Higgs sector is preserved, these effects are found to be small, of the order of the square of the gauge coupling times logarithms (but not powers) of the Higgs-boson mass divided by the W mass. We work in the context of a simplified model with gauge group SU(2)/sub L/; the extension to SU(2)/sub L/ x U(1) is briefly discussed

  5. Design of a 4 1/2 stage turbine with a stage loading factor of 4.66 and high specific work output

    Science.gov (United States)

    Webster, P. F.

    1976-01-01

    The aerodynamic design of a highly loaded multistage fan drive turbine is discussed. Turbine flowpath and airfoil sections are presented along with respective pressure and velocity distributions. Vibrational modes are identified in the expected turbine operating range.

  6. Factors associated with recent unsuppressed viral load in HIV-1-infected patients in care on first-line antiretroviral therapy in South Africa.

    Science.gov (United States)

    Joseph Davey, D; Abrahams, Z; Feinberg, M; Prins, M; Serrao, C; Medeossi, B; Darkoh, E

    2018-05-01

    Unsuppressed viral load (VL) in patients on antiretroviral therapy (ART) occurs when treatment fails to suppress a person's VL and is associated with decreased survival and increased HIV transmission. The objective of this study was to evaluate factors associated with unsuppressed VL (VL > 400 copies/ml) in patients currently in care on first-line ART for ≥ 6 months attending South African public healthcare facilities. We analysed electronic medical records of ART patients with a VL result on record who started ART between January 2004 and April 2016 from 271 public health facilities. We present descriptive and multivariable logistic regression for unsuppressed VL at last visit using a priori variables. We included 244,370 patients (69% female) on first-line ART in April 2016 for ≥ 6 months. Median age at ART start was 33 years (7% were < 15 years old). Median duration on ART was 3.7 years. Adjusting for other variables, factors associated with having an unsuppressed VL at the most recent visit among patients in care included: (1) < 15 years old at ART start (adjusted odds ratio [aOR]=2.58; 95% CI = 2.37, 2.81) versus 15-49 years at ART start, (2) male gender (aOR = 1.29; 95% CI = 1.25, 1.35), (3) 6-12 months on ART versus longer (aOR = 1.34; 95% CI = 1.29, 1.40), (4) on tuberculosis (TB) treatment (aOR = 1.78; 95% CI = 1.48, 2.13), and (5) prior ART exposure versus none (aOR = 1.20; 95% CI = 1.08, 1.32). Approximately 85% of the ART cohort who were in care had achieved viral suppression, though men, youth/adolescents, patients with prior ART exposure, those with short duration of ART, and patients on TB treatment had increased odds of not achieving viral suppression. There is a need to develop and evaluate targeted interventions for ART patients in care who are at high risk of unsuppressed VL.

  7. A Systematic Review on Immediate Loading of Implants Used to Support Overdentures Opposed by Conventional Prostheses: Factors That Might Influence Clinical Outcomes.

    Science.gov (United States)

    Zygogiannis, Kostas; Wismeijer, Daniel; Aartman, Irene Ha; Osman, Reham B

    2016-01-01

    Different treatment protocols in terms of number, diameter, and suprastructure design have been proposed for immediately loaded implants that are used to support mandibular overdentures opposed by maxillary conventional dentures. The aim of this study was to investigate the influence of these protocols on survival rates as well as clinical and prosthodontic outcomes. Several electronic databases were searched for all relevant articles published from 1966 to June 2014. Only randomized controlled trials and prospective studies with a minimum follow-up of 12 months were selected. The primary outcomes of interest were the success and survival rates of the implants. Prosthodontic complications were also evaluated. Fourteen studies fulfilled the inclusion criteria. Of the studies identified, nine were randomized controlled trials and five were prospective studies. The mean follow-up period was 3 years or less for the vast majority of the studies. The reported survival and success rates were comparable to that of conventional loading for most of the included studies. No specific immediate loading protocol seemed to perform better in terms of clinical and prosthodontic outcomes. Immediate loading protocols of mandibular overdentures seem to be a viable alternative to conventional loading. It was not possible to recommend a specific treatment protocol related to the number, diameter of the implants, and attachment system used. Long-term, well-designed studies comparing different immediate loading modalities could help to establish a protocol that delivers the most clinically predictable, efficient, and cost-effective outcome for edentulous patients in need of implant overdentures.

  8. A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells).

    Science.gov (United States)

    Yoshida, Naohiro; Kinugasa, Tetsushi; Miyoshi, Hiroaki; Sato, Kensaku; Yuge, Kotaro; Ohchi, Takafumi; Fujino, Shinya; Shiraiwa, Sachiko; Katagiri, Mitsuhiro; Akagi, Yoshito; Ohshima, Koichi

    2016-03-01

    Tumor-infiltrating lymphocytes (TILs), part of the host immune response, have been widely reported as influential factors in the tumor microenvironment for the clinical outcome of colorectal cancer (CRC). However, the network of helper T cells is very complex, and which T-cell subtypes affect the progression of CRC and postoperative prognosis remains unclear. This study investigated the expression of several subtypes of TILs including T helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) cells to determine their correlation with clinicopathologic features and postoperative prognosis. The study investigated the expression of TILs using immunohistochemistry of tissue microarray samples for 199 CRC patients. The number of each T-cell subtype infiltrating tumors was counted using ImageJ software. The relationship between TIL marker expression, clinicopathologic features, and prognosis was analyzed. A high RORγT/CD3 ratio (Th17 ratio) was significantly correlated with lymph node metastasis (p = 0.002), and a high of Foxp3/CD3 ratio (Treg ratio) was correlated with tumor location in the colon (p = 0.04), as shown by the Chi square test. In multivariate analysis, a high RORγT/CD3 ratio was the only independent prognostic factor for overall survival (p = 0.04; hazard ratio [HR], 1.84; 95% confidence interval [CI] 1.02-3.45). This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.

  9. New determination of the D0→K-π+π0 and D0→K-π+π+π- coherence factors and average strong-phase differences

    Science.gov (United States)

    Libby, J.; Malde, S.; Powell, A.; Wilkinson, G.; Asner, D. M.; Bonvicini, G.; Briere, R. A.; Gershon, T.; Naik, P.; Pedlar, T. K.; Rademacker, J.; Ricciardi, S.; Thomas, C.

    2014-04-01

    Measurements of the coherence factors (R and R) and the average strong-phase differences (δDKππ0 and δDK3π) for the decays D0→K-π+π0 and D0→K-π+π+π- are presented. These parameters are important inputs to the determination of the unitarity triangle angle γ in B∓→DK∓ decays, where D designates a D0 or D meson decaying to a common final state. The measurements are made using quantum correlated DDbar decays collected by the CLEO-c experiment at the ψ(3770) resonance, and augment a previously published analysis by the inclusion of new events in which the signal decay is tagged by the mode D→KS0π+π-. The measurements also benefit from improved knowledge of external inputs, namely the D0D mixing parameters, rDKπ and several D-meson branching fractions. The measured values are R=0.82±0.07, δDKππ0=(164-14+20)°, R=0.32-0.28+0.20 and δDK3π=(225-78+21)°. Consideration is given to how these measurements can be improved further by using the larger quantum-correlated data set collected by BESIII.

  10. John Strong (1941 - 2006)

    CERN Multimedia

    Wickens, F

    Our friend and colleague John Strong was cruelly taken from us by a brain tumour on Monday 31st July, a few days before his 65th birthday John started his career working with a group from Westfield College, under the leadership of Ted Bellamy. He obtained his PhD and spent the early part of his career on experiments at Rutherford Appleton Laboratory (RAL), but after the early 1970s his research was focussed on experiments in CERN. Over the years he made a number of notable contributions to experiments in CERN: The Omega spectrometer adopted a system John had originally developed for experiments at RAL using vidicon cameras to record the sparks in the spark chambers; He contributed to the success of NA1 and NA7, where he became heavily involved in the electronic trigger systems; He was responsible for the second level trigger system for the ALEPH detector and spent five years leading a team that designed and built the system, which ran for twelve years with only minor interventions. Following ALEPH he tur...

  11. Stirring Strongly Coupled Plasma

    CERN Document Server

    Fadafan, Kazem Bitaghsir; Rajagopal, Krishna; Wiedemann, Urs Achim

    2009-01-01

    We determine the energy it takes to move a test quark along a circle of radius L with angular frequency w through the strongly coupled plasma of N=4 supersymmetric Yang-Mills (SYM) theory. We find that for most values of L and w the energy deposited by stirring the plasma in this way is governed either by the drag force acting on a test quark moving through the plasma in a straight line with speed v=Lw or by the energy radiated by a quark in circular motion in the absence of any plasma, whichever is larger. There is a continuous crossover from the drag-dominated regime to the radiation-dominated regime. In the crossover regime we find evidence for significant destructive interference between energy loss due to drag and that due to radiation as if in vacuum. The rotating quark thus serves as a model system in which the relative strength of, and interplay between, two different mechanisms of parton energy loss is accessible via a controlled classical gravity calculation. We close by speculating on the implicati...

  12. Load sensor

    OpenAIRE

    Van den Ende, D.; Almeida, P.M.R.; Dingemans, T.J.; Van der Zwaag, S.

    2007-01-01

    The invention relates to a load sensor comprising a polymer matrix and a piezo-ceramic material such as PZT, em not bedded in the polymer matrix, which together form a compos not ite, wherein the polymer matrix is a liquid crystalline resin, and wherein the piezo-ceramic material is a PZT powder forming 30-60% by volume of the composite, and wherein the PZT powder forms 40-50% by volume of the composite.

  13. Behaviour of eggshell membranes at tensile loading

    Czech Academy of Sciences Publication Activity Database

    Strnková, M.J.; Nedomová, Š.; Trnka, Jan; Buchar, J.; Kumbár, V.

    46 B, December (2014), s. 44-48 ISSN 0324-1130 Institutional support: RVO:61388998 Keywords : eggshell membrane * tensile loading * loading rate * stress * strain strength Subject RIV: GM - Food Processing Impact factor: 0.201, year: 2014

  14. Fatores de marketing na construção de marcas sólidas: estudo exploratório com marcas brasileiras Marketing factors for building strong brands: an exploratory Brazilian study

    Directory of Open Access Journals (Sweden)

    Daniela Motta Romeiro Khauaja

    2006-12-01

    Full Text Available Este estudo se propôs a investigar o processo de construção de marcas sólidas criadas e desenvolvidas no Brasil e comercializadas por empresas de controle acionário brasileiro. O objetivo geral foi ampliar o conhecimento sobre os fatores de marketing voltados para a construção de marcas sólidas. Conduziu-se uma pesquisa exploratória, de caráter qualitativo, por meio do estudo dos casos de construção das marcas Gol, O Boticário e DPaschoal. Seguiu-se a lógica da replicação literal. Cada caso particular consistiu em um estudo completo, cujas conclusões foram comparadas para que se indicasse a extensão da lógica da replicação. Concluiu-se que a adoção do conjunto de todos os fatores de marketing foi o que ajudou as três marcas estudadas a se construir e a se tornar tão sólidas quanto são atualmente. Com base nas conclusões e levando-se em consideração as limitações do método da pesquisa, foram efetuadas recomendações sobre procedimentos e ações para a construção de marcas sólidas no Brasil.Strong brands developed for use by Brazilian owned companies were investigated to better understand marketing aspects involved. A qualitative exploratory case study was conducted for each of the brands, Gol, O Boticario and DPaschoal. Work was done and reported separately to facilitate identification of the extent of replication logic. Results indicated that a combination of all Marketing factors was necessary to achieve the current solidity of these brands which, however, did not necessarily imply perfection. Conclusions were included in recommendations for building strong Brazilian brands.

  15. Strong growth for Queensland mining

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-01

    The Queensland mining industry experienced strong growth during 1989-90 as shown in the latest statistics released by the Department of Resource Industries. The total value of Queensland mineral and energy production rose to a new record of $5.1 billion, an increase of 16.5% on 1988-89 production. A major contributing factor was a 20.9 percent increase in the value of coal production. While the quantity of coal produced rose only 1.1 percent, the substantial increase in the value of coal production is attributable to higher coal prices negotiated for export contracts. In Australian dollar terms coal, gold, lead, zinc and crude oil on average experienced higher international prices than in the previous year. Only copper and silver prices declined. 3 tabs.

  16. Effect of water deprivation, desmopressin (DDAVP) infusion, and oral loads of water, Na+ and NH4+ on urinary excretion of epidermal growth factor in the rat

    DEFF Research Database (Denmark)

    Jørgensen, P E; Poulsen, Steen Seier; Nexø, Ebba

    1993-01-01

    for urinary EGF we examined the effects of changes in the oral loads of water, Na+ and NH4+ as well as the effect of infusion of the vasopressin analogue, desmopressin (DDAVP) on the endogenous urinary EGF excretion in the rat. Water deprivation for 48 h reduced the urinary excretion of EGF by 25...

  17. Load equivalency factors (LEFs) for abnormal vehicles (AVs) and mobile cranes in South Africa based on the mechanistic-empirical (M-E) design methodology

    CSIR Research Space (South Africa)

    De Beer, Morris

    2009-07-01

    Full Text Available layer life of pavement under the loading of Axle of vehicle in question. v n ii=1 Total Additional Damage of Vehicle = TAD (Ncritical from Standard 80 kN/520 kPa Axle) (Ncritical from Legal 88 kN/700 kPa Axle) -(Ncritical from Axle...

  18. A systematic review on immediate loading of implants used to support overdentures opposed by conventional prostheses : factors that might influence clinical outcomes

    NARCIS (Netherlands)

    Zygogiannis, K.; Wismeijer, D.; Aartman, I.H.A.; Osman, R.B.

    2016-01-01

    Purpose: Different treatment protocols in terms of number, diameter, and suprastructure design have been proposed for immediately loaded implants that are used to support mandibular overdentures opposed by maxillary conventional dentures. The aim of this study was to investigate the influence of

  19. The role of the vascular endothelial growth factor/vascular endothelial growth factor receptors axis mediated angiogenesis in curcumin-loaded nanostructured lipid carriers induced human HepG2 cells apoptosis

    Directory of Open Access Journals (Sweden)

    Fengling Wang

    2015-01-01

    Full Text Available Background: Curcumin (diferuloylmethane, the active constituent of turmeric extract has potent anti-cancer properties have been demonstrated in hepatocellular carcinoma (HCC. However, its underlying molecular mechanism of therapeutic effects remains unclear. Vascular endothelial growth factor (VEGF and its receptors (VEGFRs have crucial roles in tumor angiogenesis. Purpose: The goal of this study was to investigate the role of the VEGF/VEGFRs mediated angiogenesis during the proliferation and apoptosis of human HepG2 hepatoma cell line and the effect of curcumin-loaded nanostructured lipid carriers (Cur-NLC. Materials and Methods: The proliferation of HepG2 cells was determined by methyl thiazolyl tetrazolium after exposure to Cur-NLC and native curcumin. Apoptosis was quantified by flow cytometry with annexin V-fluorescein isothiocyanate and propidium iodide staining. Cellular internalization of Cur-NLC was observed by fluorescent microscope. The level of VEGF was detected by enzyme-linked immunosorbent assay kits. The expression of VEGFRs was quantified by Western blotting. Results: Cur-NLC was more effective in inhibiting the proliferation and enhancing the apoptosis of HepG2 cells than native curcumin. Fluorescent microscope analysis showed that HepG2 cells internalized Cur-NLC more effectively than native curcumin. Furthermore, Cur-NLC down-regulated the level of VEGF and the expression of VEGFR-2, but had a slight effect on VEGFR-1. Conclusion: These results clearly demonstrated that Cur-NLC was more effective in anti-cancer activity than the free form of curcumin. These studies demonstrate for the 1 st time that Cur-NLC exerts an antitumor effect on HepG2 cells by modulating VEGF/VEGFRs signaling pathway.

  20. Testing strong factorial invariance using three-level structural equation modeling

    Directory of Open Access Journals (Sweden)

    Suzanne eJak

    2014-07-01

    Full Text Available Within structural equation modeling, the most prevalent model to investigate measurement bias is the multigroup model. Equal factor loadings and intercepts across groups in a multigroup model represent strong factorial invariance (absence of measurement bias across groups. Although this approach is possible in principle, it is hardly practical when the number of groups is large or when the group size is relatively small. Jak, Oort and Dolan (2013 showed how strong factorial invariance across large numbers of groups can be tested in a multilevel structural equation modeling framework, by treating group as a random instead of a fixed variable. In the present study, this model is extended for use with three-level data. The proposed method is illustrated with an investigation of strong factorial invariance across 156 school classes and 50 schools in a Dutch dyscalculia test, using three-level structural equation modeling.

  1. Identifying interactive effects of task demands in lifting on estimates of in vivo low back joint loads.

    Science.gov (United States)

    Gooyers, Chad E; Beach, Tyson A C; Frost, David M; Howarth, Samuel J; Callaghan, Jack P

    2018-02-01

    This investigation examined interactions between the magnitude of external load, movement speed and (a)symmetry of load placement on estimates of in vivo joint loading in the lumbar spine during simulated occupational lifting. Thirty-two participants with manual materials handling experience were included in the study. Three-dimensional motion data, ground reaction forces, and activation of six bilateral trunk muscle groups were captured while participants performed lifts with two loads at two movement speeds and using two load locations. L4-L5 joint compression and shear force-time histories were estimated using an EMG-assisted musculoskeletal model of the lumbar spine. Results from this investigation provide strong evidence that known mechanical low back injury risk factors should not be viewed in isolation. Rather, injury prevention efforts need to consider the complex interactions that exist between external task demands and their combined influence on internal joint loading. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Effect of operational factors on bioregeneration of binary phenol and 4-chlorophenol-loaded granular activated carbon using PVA-immobilized biomass cryogels.

    Science.gov (United States)

    Leong, Kwok-Yii; Adnan, Rohana; Lim, Poh-Eng; Ng, Si-Ling; Seng, Chye-Eng

    2017-09-01

    The effects of dry biomass density in cryogel beads, shaking speed and initial concentration ratio of phenol to 4-chlorophenol (4-CP) on the bioregeneration efficiencies of binary phenol and 4-CP-loaded granular activated carbon (GAC) for phenol and 4-CP, respectively, were investigated under the simultaneous adsorption and biodegradation approach. The results revealed higher bioregeneration efficiencies of binary-loaded GAC for phenol and 4-CP at higher dry biomass density but moderate shaking speed. The optimum dry biomass density in cryogel beads and shaking speed for use in bioregeneration were found to be 0.01 g/mL and 250 rpm, respectively. With respect to the initial phenol to 4-CP concentration ratio, the bioregeneration efficiencies were lower under increasing phenol and 4-CP initial concentrations, respectively, with the effect being more conspicuous under increasing 4-CP concentration. Higher bioregeneration efficiencies were achieved with the use of immobilized rather than suspended biomasses.

  3. Load Estimation from Natural input Modal Analysis

    DEFF Research Database (Denmark)

    Aenlle, Manuel López; Brincker, Rune; Canteli, Alfonso Fernández

    2005-01-01

    One application of Natural Input Modal Analysis consists in estimating the unknown load acting on structures such as wind loads, wave loads, traffic loads, etc. In this paper, a procedure to determine loading from a truncated modal model, as well as the results of an experimental testing programme...... estimation. In the experimental program a small structure subjected to vibration was used to estimate the loading from the measurements and the experimental modal space. The modal parameters were estimated by Natural Input Modal Analysis and the scaling factors of the mode shapes obtained by the mass change...

  4. Load testing circuit

    DEFF Research Database (Denmark)

    2009-01-01

    A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

  5. Some pollinators are more equal than others: Factors influencing pollen loads and seed set capacity of two actively and passively pollinating fig wasps

    Science.gov (United States)

    Kjellberg, Finn; Suleman, Nazia; Raja, Shazia; Tayou, Abelouahad; Hossaert-McKey, Martine; Compton, Stephen G.

    2014-05-01

    The nursery pollination system of fig trees (Ficus) results in the plants providing resources for pollinator fig wasp larvae as part of their male reproductive investment, with selection determining relative investment into pollinating wasps and the pollen they carry. The small size of Ficus pollen suggests that the quantities of pollen transported by individual wasps often limits male reproductive success. We assessed variation in fig wasp pollen loads and its influence on seed production in actively pollinated (Ficus montana) and passively pollinated (Ficus carica) dioecious fig trees.

  6. John Strong - 1941-2006

    CERN Multimedia

    2006-01-01

    Our friend and colleague John Strong was cruelly taken from us by a brain tumour on 31 July, a few days before his 65th birthday. John started his career and obtained his PhD in a group from Westfield College, initially working on experiments at Rutherford Appleton Laboratory (RAL). From the early 1970s onwards, however, his research was focused on experiments in CERN, with several particularly notable contributions. The Omega spectrometer adopted a system John had originally developed for experiments at RAL using vidicon cameras (a type of television camera) to record the sparks in the spark chambers. This highly automated system allowed Omega to be used in a similar way to bubble chambers. He contributed to the success of NA1 and NA7, where he became heavily involved in the electronic trigger systems. In these experiments the Westfield group joined forces with Italian colleagues to measure the form factors of the pion and the kaon, and the lifetime of some of the newly discovered charm particles. Such h...

  7. Loads and loads and loads: The influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Directory of Open Access Journals (Sweden)

    Beat eMeier

    2015-06-01

    Full Text Available In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of prospective load on costs in the ongoing task for categorical targets (Experiment 2, but not for specific targets (Experiment 1. Retrospective load and ongoing task load both affected remembering the retrospective component of the prospective memory task. We suggest that prospective load can enhance costs in the ongoing task due to additional monitoring requirements. Retrospective load and ongoing task load seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  8. Aperture averaging in strong oceanic turbulence

    Science.gov (United States)

    Gökçe, Muhsin Caner; Baykal, Yahya

    2018-04-01

    Receiver aperture averaging technique is employed in underwater wireless optical communication (UWOC) systems to mitigate the effects of oceanic turbulence, thus to improve the system performance. The irradiance flux variance is a measure of the intensity fluctuations on a lens of the receiver aperture. Using the modified Rytov theory which uses the small-scale and large-scale spatial filters, and our previously presented expression that shows the atmospheric structure constant in terms of oceanic turbulence parameters, we evaluate the irradiance flux variance and the aperture averaging factor of a spherical wave in strong oceanic turbulence. Irradiance flux variance variations are examined versus the oceanic turbulence parameters and the receiver aperture diameter are examined in strong oceanic turbulence. Also, the effect of the receiver aperture diameter on the aperture averaging factor is presented in strong oceanic turbulence.

  9. Rotating compressible fluids under strong stratification

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard; Lu, Y.; Novotný, A.

    2014-01-01

    Roč. 19, October (2014), s. 11-18 ISSN 1468-1218 Keywords : rotating fluid * compressible Navier-Stokes * strong stratification Subject RIV: BA - General Mathematics Impact factor: 2.519, year: 2014 http://www.sciencedirect.com/science/article/pii/S1468121814000212#

  10. Quantum electrodynamics of strong fields

    International Nuclear Information System (INIS)

    Greiner, W.

    1983-01-01

    Quantum Electrodynamics of Strong Fields provides a broad survey of the theoretical and experimental work accomplished, presenting papers by a group of international researchers who have made significant contributions to this developing area. Exploring the quantum theory of strong fields, the volume focuses on the phase transition to a charged vacuum in strong electric fields. The contributors also discuss such related topics as QED at short distances, precision tests of QED, nonperturbative QCD and confinement, pion condensation, and strong gravitational fields In addition, the volume features a historical paper on the roots of quantum field theory in the history of quantum physics by noted researcher Friedrich Hund

  11. Instabilities in strongly coupled plasmas

    CERN Document Server

    Kalman, G J

    2003-01-01

    The conventional Vlasov treatment of beam-plasma instabilities is inappropriate when the plasma is strongly coupled. In the strongly coupled liquid state, the strong correlations between the dust grains fundamentally affect the conditions for instability. In the crystalline state, the inherent anisotropy couples the longitudinal and transverse polarizations, and results in unstable excitations in both polarizations. We summarize analyses of resonant and non-resonant, as well as resistive instabilities. We consider both ion-dust streaming and dust beam-plasma instabilities. Strong coupling, in general, leads to an enhancement of the growth rates. In the crystalline phase, a resonant transverse instability can be excited.

  12. Low-back loading in lifting two loads beside the body compared to lifting one load in front of the body

    NARCIS (Netherlands)

    Faber, G.S.; Kingma, I.; Bakker, A.J.; van Dieen, J.H.

    2009-01-01

    Low-back load during manual lifting is considered an important risk factor for the occurrence of low-back pain. Splitting a load, so it can be lifted beside the body (one load in each hand), instead of in front of the body, can be expected to reduce low-back load. Twelve healthy young men lifted 10

  13. Short proofs of strong normalization

    OpenAIRE

    Wojdyga, Aleksander

    2008-01-01

    This paper presents simple, syntactic strong normalization proofs for the simply-typed lambda-calculus and the polymorphic lambda-calculus (system F) with the full set of logical connectives, and all the permutative reductions. The normalization proofs use translations of terms and types to systems, for which strong normalization property is known.

  14. LIGHT-WEIGHT LOAD-BEARING STRUCTURE

    DEFF Research Database (Denmark)

    2009-01-01

    The invention relates to a light-weight load-bearing structure (1) with optimized compression zone (2), where along one or more compression zones (2) in the structure (1) to be cast a core (3) of strong concrete is provided, which core (3) is surrounded by concrete of less strength (4) compared...... to the core (3) of strong concrete. The invention also relates to a method of casting of light-weight load-bearing structures (1) with optimized compression zone (2) where one or more channels, grooves, ducts, pipes and/or hoses (5) formed in the load-bearing structure (1) serves as moulds for moulding one...... or more cores (3) of strong concrete in the light-weight load-bearing structure (1)....

  15. Distribution load estimation (DLE)

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A; Lehtonen, M [VTT Energy, Espoo (Finland)

    1998-08-01

    The load research has produced customer class load models to convert the customers` annual energy consumption to hourly load values. The reliability of load models applied from a nation-wide sample is limited in any specific network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to find improvements to the load models or, in general, improvements to the load estimates. In Distribution Load Estimation (DLE) the measurements from the network are utilized to improve the customer class load models. The results of DLE will be new load models that better correspond to the loading of the distribution network but are still close to the original load models obtained by load research. The principal data flow of DLE is presented

  16. Chloride concentrations, loads, and yields in four watersheds along Interstate 95, southeastern Connecticut, 2008-11: factors that affect peak chloride concentrations during winter storms

    Science.gov (United States)

    Brown, Craig J.; Mullaney, John R.; Morrison, Jonathan; Martin, Joseph W.; Trombley, Thomas J.

    2015-07-01

    Chloride (Cl-) concentrations and loads and other water chemistry characteristics were assessed to evaluate potential effects of road-deicer applications on streamwater quality in four watersheds along Interstate 95 (I–95) in southeastern Connecticut from November 1, 2008, through September 30, 2011. Streamflow and water quality were studied in the Four Mile River, Oil Mill Brook, Stony Brook, and Jordan Brook watersheds, where developed land ranged from 9 to 32 percent. Water-quality samples were collected and specific conductance was measured continuously at paired water-quality monitoring sites, upstream and downstream from I–95. Specific conductance values were related to Cl- concentrations to assist in determining the effects of road-deicing operations on the levels of Cl-in the streams. Streamflow and water-quality data were compared with weather data and with the timing, amount, and composition of deicers applied to State highways. Grab samples were collected during winter stormwater-runoff events, such as winter storms or periods of rain or warm temperatures in which melting takes place. Grab samples were also collected periodically during the spring and summer and during base-flow conditions.

  17. Distribution load estimation - DLE

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A. [VTT Energy, Espoo (Finland)

    1996-12-31

    The load research project has produced statistical information in the form of load models to convert the figures of annual energy consumption to hourly load values. The reliability of load models is limited to a certain network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to make improvements in the load models. Distribution load estimation (DLE) is the method developed here to improve load estimates from the load models. The method is also quite cheap to apply as it utilises information that is already available in SCADA systems

  18. Distribution load estimation - DLE

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A [VTT Energy, Espoo (Finland)

    1997-12-31

    The load research project has produced statistical information in the form of load models to convert the figures of annual energy consumption to hourly load values. The reliability of load models is limited to a certain network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to make improvements in the load models. Distribution load estimation (DLE) is the method developed here to improve load estimates from the load models. The method is also quite cheap to apply as it utilises information that is already available in SCADA systems

  19. Intelligence Tests with Higher G-Loadings Show Higher Correlations with Body Symmetry: Evidence for a General Fitness Factor Mediated by Developmental Stability

    Science.gov (United States)

    Prokosch, M.D.; Yeo, R.A.; Miller, G.F.

    2005-01-01

    Just as body symmetry reveals developmental stability at the morphological level, general intelligence may reveal developmental stability at the level of brain development and cognitive functioning. These two forms of developmental stability may overlap by tapping into a ''general fitness factor.'' If so, then intellectual tests with higher…

  20. Probability Based Evaluation of Vehicular Bridge Load using Weigh-in-Motion Data

    OpenAIRE

    Widi Nugraha; Indra Djati Sidi

    2016-01-01

    Load and Resistance Factored Design (LRFD) method for designing bridge in Indonesia have been implemented for more than 25 years. LRFD method treating loads and strengths variables as random variables with specific safety factors for different loads and strengths variables type. The nominal loads, load factors, reduction factors, and other criteria for bridge design code can be determined to meet the reliability criteria. Statistical data of weigh-in-motion (WIM) vehicular loads measurement i...

  1. +Gz load and executive functions.

    Science.gov (United States)

    Biernacki, Marcin P; Tarnowski, Adam; Lengsfeld, Kamila; Lewkowicz, Rafał; Kowalczuk, Krzysztof; Dereń, Miroslaw

    2013-05-01

    Pilots are constantly exposed to a number of environmental factors, which include +Gz load. Physiological changes evoked by +Gz stimuli have already been well investigated in aviation medicine. However, the influence of +Gz stimulation on executive functions in pilots has not yet been thoroughly explored. There were 20 pilot cadets between the ages of 19 and 22 yr who volunteered to participate in the experiment. The subjects were divided into two groups: the G-load group, which was exposed to accelerations in the centrifuge, and the control group, which did not undergo this stimulation. Executive functions were assessed by means of the Schulte tables and the Rey-Osterrieth complex figure test. +Gz load exposure significantly improved attention switching. This relationship was valid for performance speed (M = 268.09 s in the pretest in the G-load group; M = 228.09 s in the posttest in the G-load group) and for the cumulative time of mistakes (M = 26.73 s in the pretest in the G-load group; M = 12 s in the posttest in the G-load group), whereas reproduction of visuospatial stimuli from memory deteriorated significantly under the influence of +Gz stimulation (M = 17.18 points in the posttest in the G-load group; M = 28.18 points in the posttest in the control group). These results suggest that the impact of +Gz load is not homogenous and unidirectional, since it improves attention switching but visuospatial working memory decreases under its influence. These aspects are particularly important for understanding the mechanisms responsible for maintaining situational awareness during the flight.

  2. Reliability analysis of RC containment structures under combined loads

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Kagami, S.

    1984-01-01

    This paper discusses a reliability analysis method and load combination design criteria for reinforced concrete containment structures under combined loads. The probability based reliability analysis method is briefly described. For load combination design criteria, derivations of the load factors for accidental pressure due to a design basis accident and safe shutdown earthquake (SSE) for three target limit state probabilities are presented

  3. Effect of Water Vapor Pressure on Fatigue Crack Growth in Al-Zn-Cu-Mg Alloy Over Wide-Range Stress Intensity Factor Loading

    Science.gov (United States)

    2014-05-07

    pressure and frequency on fatigue behaviour in 7017-T651 aluminium alloy plate, Acta Mater, 45 (1997) 281-293. [30) N.J.H. Holroyd, D. Hardie, Factors... aluminium alloys , Acta Mater, 45 (1997) 3855-3870. [33) S. Lynch, Hydrogen embrittlement phenomena and mechanisms, Corros Rev, 30 (2012) 105-123. [34...role of environmental exposure in the fatigue behaviour of an aluminium alloy , Corros Sci, 39 (1997) 2117-2141. [39) R.S. Piascik, R.P. Gangloff

  4. Voltage-Sharing Converter to Supply Single-Phase Asymmetrical Four-Level Diode-Clamped Inverter With High Power Factor Loads

    DEFF Research Database (Denmark)

    Boora, Arash A.; Nami, Alireza; Zare, Firuz

    2010-01-01

    The output voltage quality of some of the single-phase multilevel inverters can be improved when their dc-link voltages are regulated asymmetrically. Symmetrical and asymmetrical multilevel diode-clamped inverters have the problem of dc-link capacitor voltage balancing, especially when power factor...... that the proposed combination of introduced multioutput dc–dc converter and single-phase ADCI is a good candidate for power conversion in residential photovoltaic (PV) utilization....

  5. electrical load survey electrical load survey and forecast

    African Journals Online (AJOL)

    eobe

    scattered nature of the area and low load factor. In this ... employment and allow decentralized production of the ... and viable concept from energy production and .... VII Yr. ×. kWh. VIII Yr. ×. kWh. IX Yr. ×. kWh. X Yr. ×. kWh. 1. Residential. 147.

  6. C.A.P. Follow up of the transients and use factors for the most loaded elements of the primary circuit

    International Nuclear Information System (INIS)

    Gaouditz, N.; Chabre, A.; Lecourtois, Y.

    1979-01-01

    The control authorities of all countries lay down increasingly stricter rules for the definition, fabrication and maintenance of nuclear capacities under pressure. In particular the operator has to ensure that the apparatus does not have to withstand stresses greater in number, intensity and rapidity than those allowed for in the project. In other words he must workout, classify and combine the various transients supported by the apparatus throughout its lifetime. The account method enables the actual transients to be classified in relation to the reference transients and their cumulated number followed periodically. This number can then be used to find the use factor which, when extrapolated to the lifetime of the element concerned, must be lower or equal to the use factor provided in the design always less than one. In point of fact, although simple in formulation, this becomes fairly complicated in application for a particular point of the capacity may be subjected to a great number of various types of stresses, each one leading to a particular damage of which the use factors, f, will be cumulated in accordance with the rules stipulated in the ASME Code, section III [fr

  7. Factors affecting the prevalence of strongly and weakly carcinogenic and lower-risk human papillomaviruses in anal specimens in a cohort of men who have sex with men (MSM.

    Directory of Open Access Journals (Sweden)

    Dorothy J Wiley

    Full Text Available MSM are at higher risk for invasive anal cancer. Twelve human papillomaviruses (HPVs cause cervical cancer in women (Group 1 high-risk HPVs (hrHPVs and 13 HPVs are probable/possible causes (Group 2 hrHPVs of cervical malignancy. HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs.Dacron-swab anal-cytology specimens were collected from and data complete for 97% (1262/1296 of Multicenter AIDS Cohort Study (MACS men tested for HPVs using the Linear Array assay. Multivariate Poisson regression analyses estimated adjusted prevalence ratios for Group 1/2 hrHPVs and lrHPVs, controlling for the effects of age, race, ethnicity, sexual partnerships, smoking; HIV-infection characteristics, treatment, and immune status among HIV-infected men.HIV-infected men showed 35-90% higher prevalence of Group 1/2 hrHPVs and lrHPVs than HIV-uninfected men, and higher prevalence of multi-Type, and multiple risk-group infections. CD4+ T-cell count was inversely associated with HPV Group 2 prevalence (p<0.0001. The number of receptive anal intercourse (RAI partners reported in the 24 months preceding HPV testing predicted higher prevalence of Group 1/2 hrHPVs. Men reporting ≥30 lifetime male sex partners before their first MACS visit and men reporting ≥1 RAI partners during the 24 months before HPV testing showed 17-24% and 13-17% higher prevalence of lrHPVs (p-values ≤0.05. Men reporting smoking between MACS visit 1 and 24 months before HPV testing showed 1.2-fold higher prevalence of Group 2 hrHPVs (p = 0.03. Both complete adherence to CART (p = 0.02 and HIV load <50 copies/mL (p = 0.04 were protective for Group 1 hrHPVs among HIV-infected men.HIV-infected men more often show multi-type and multi-group HPV infections HIV-uninfected men. Long-term mutual monogamy and smoking cessation, generally, and CART-adherence that promotes (HIV viremia control and prevents immunosuppression, specifically among HIV-infected MSM, are

  8. Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in ehrlich lettré ascites cells through a mechanism involving p38 mitogen-activated protein kinase

    DEFF Research Database (Denmark)

    Gorbatenko, Andrej; Wiwel, Maria; Klingberg, Henrik

    2011-01-01

    Long-term osmotic stress results in altered gene transcription, however, with the exception of the TonE/TonEBP system, the underlying mechanisms are poorly understood. We previously showed that upon osmotic shrinkage of Ehrlich Lettré Ascites (ELA) fibroblasts, the MEK1-ERK1/2 pathway is transien......Long-term osmotic stress results in altered gene transcription, however, with the exception of the TonE/TonEBP system, the underlying mechanisms are poorly understood. We previously showed that upon osmotic shrinkage of Ehrlich Lettré Ascites (ELA) fibroblasts, the MEK1-ERK1/2 pathway......) and cAMP response element-binding protein (CREB) are differentially regulated in ELA cells. SRF Ser103 phosphorylation and SRF-dependent transcriptional activity were strongly augmented 5–30¿min and 24¿h, respectively, after hyperosmotic stress (50% increase in extracellular ionic strength), in a p38...... dephosphorylated within 5¿min of shrinkage. MSK1 phosphorylation recovered within 30¿min in a p38-MAPK-dependent manner. CREB was transiently dephosphorylated after shrinkage in a manner exacerbated by p38 MAPK inhibition or MSK1 knockdown, but unaffected by inhibition of RSK. In conclusion, in ELA cells...

  9. Strong coupling phase in QED

    International Nuclear Information System (INIS)

    Aoki, Ken-ichi

    1988-01-01

    Existence of a strong coupling phase in QED has been suggested in solutions of the Schwinger-Dyson equation and in Monte Carlo simulation of lattice QED. In this article we recapitulate the previous arguments, and formulate the problem in the modern framework of the renormalization theory, Wilsonian renormalization. This scheme of renormalization gives the best understanding of the basic structure of a field theory especially when it has a multi-phase structure. We resolve some misleading arguments in the previous literature. Then we set up a strategy to attack the strong phase, if any. We describe a trial; a coupled Schwinger-Dyson equation. Possible picture of the strong coupling phase QED is presented. (author)

  10. Strong adverse effect of epidermal growth factor receptor 2 overexpression on prognosis of patients with invasive lobular breast cancer: a comparative study with invasive ductal breast cancer in Chinese population.

    Science.gov (United States)

    Wang, Tong; Ma, Yuanyuan; Wang, Liang; Liu, Hong; Chen, Meixuan; Niu, Ruifang

    2015-08-01

    The data on the outcome of breast invasive lobular carcinoma (ILC) are conflicting. In addition, the prognostic effect of molecular subtypes on ILC remains unclear. In this study, the clinicopathological and prognostic data between 269 ILC and 816 invasive ductal carcinoma (IDC) cases in a Chinese population were extensively compared, with a median follow-up time of 7.8 years. Compared with the IDC group, ILC tumors had more lymph node invasion, hormonal receptor positivity, and human epidermal growth factor receptor 2 (HER2) negativity. ILC patients showed overall survival (OS) and recurrence/metastasis-free survival (RFS) rates similar to those of IDC patients but exhibited worse disease-free survival (DFS) rate because of the higher rate of contralateral breast cancer (BC). Further analysis showed that OS, RFS, and DFS were similar between ILC and IDC patients in the subgroups of luminal A and triple-negative BC with HER2 negativity but were worse in ILC patients than those in IDC patients in the subgroups of luminal B and HER2 overexpression with positive HER2 expression. Multivariate analysis indicated HER2 positivity as an independent risk factor for OS, RFS, and DFS of ILC patients, which increased the risk in the ILC group than that in IDC group. The interaction of HER2 and ILC was also defined as an independent risk factor for OS, RFS, and DFS of the entire population. In conclusion, overexpression of HER2 exhibited stronger negative effect on the prognosis of ILC patients than that in IDC patients, suggesting that treatment targeting HER2 is crucial for this BC subgroup.

  11. Simulation of PV/FC power hybrid system. Change of system capacity with load form factor; Taiyoko hatsuden nenryo denchi hybrid system no simulation. Fuka keijoritsu ni yoru system yoryo no henka

    Energy Technology Data Exchange (ETDEWEB)

    Sekiguchi, N.; Tani, T. [Science University of Tokyo, Tokyo (Japan)

    1997-11-25

    Study is conducted of a photovoltaic/fuel-cell hybrid system whose power storage is a hydrogen storage that uses a hydrogen absorbing alloy. In a simulation in this research, the solar cell conversion efficiency is changed from 15.0% to 21.0% and the fuel cell power conversion efficiency from 40.0% to 50.0%, and the resultant changes in the capacity and operation rate are investigated for each of the devices in the system. The findings follow. A 1.0% change in the solar cell conversion efficiency results in a 4.8kW change in the solar cell capacity and a 1.6-ton change in the hydrogen storage capacity. With a 1.0% change in the fuel cell power conversion efficiency, there is a 14.7kW change in the solar cell capacity and a 5.3-ton change in the hydrogen storage capacity. The fuel cell capacity is not dependent on the solar cell conversion efficiency or fuel cell power conversion efficiency but on the maximum load in each of the load form factors. The rate of occurrence of an operation rate of less than 30% is 54.7% both in DC/DC converter and hydrogen generator, 24.6% in fuel cells, and 16.7% in the DC/DC inverter. 7 refs., 7 figs., 1 tab.

  12. Strong interactions at high energy

    International Nuclear Information System (INIS)

    Anselmino, M.

    1995-01-01

    Spin effects in strong interaction high energy processes are subtle phenomena which involve both short and long distance physics and test perturbative and non perturbative aspects of QCD. Moreover, depending on quantities like interferences between different amplitudes and relative phases, spin observables always test a theory at a fundamental quantum mechanical level; it is then no surprise that spin data are often difficult to accommodate within the existing models. A report is made on the main issues and contributions discussed in the parallel Session on the open-quote open-quote Strong interactions at high energy close-quote close-quote in this Conference. copyright 1995 American Institute of Physics

  13. Strong-field dissociation dynamics

    International Nuclear Information System (INIS)

    DiMauro, L.F.; Yang, Baorui.

    1993-01-01

    The strong-field dissociation behavior of diatomic molecules is examined under two distinctive physical scenarios. In the first scenario, the dissociation of the isolated hydrogen and deuterium molecular ions is discussed. The dynamics of above-threshold dissociation (ATD) are investigated over a wide range of green and infrared intensities and compared to a dressed-state model. The second situation arises when strong-field neutral dissociation is followed by ionization of the atomic fragments. The study results in a direct measure of the atomic fragment's ac-Stark shift by observing the intensity-dependent shifts in the electron or nuclear fragment kinetic energy. 8 figs., 14 refs

  14. Probabilistic Capacity Assessment of Lattice Transmission Towers under Strong Wind

    Directory of Open Access Journals (Sweden)

    Wei eZhang

    2015-10-01

    Full Text Available Serving as one key component of the most important lifeline infrastructure system, transmission towers are vulnerable to multiple nature hazards including strong wind and could pose severe threats to the power system security with possible blackouts under extreme weather conditions, such as hurricanes, derechoes, or winter storms. For the security and resiliency of the power system, it is important to ensure the structural safety with enough capacity for all possible failure modes, such as structural stability. The study is to develop a probabilistic capacity assessment approach for transmission towers under strong wind loads. Due to the complicated structural details of lattice transmission towers, wind tunnel experiments are carried out to understand the complex interactions of wind and the lattice sections of transmission tower and drag coefficients and the dynamic amplification factor for different panels of the transmission tower are obtained. The wind profile is generated and the wind time histories are simulated as a summation of time-varying mean and fluctuating components. The capacity curve for the transmission towers is obtained from the incremental dynamic analysis (IDA method. To consider the stochastic nature of wind field, probabilistic capacity curves are generated by implementing IDA analysis for different wind yaw angles and different randomly generated wind speed time histories. After building the limit state functions based on the maximum allowable drift to height ratio, the probabilities of failure are obtained based on the meteorological data at a given site. As the transmission tower serves as the key nodes for the power network, the probabilistic capacity curves can be incorporated into the performance based design of the power transmission network.

  15. The effect of Fe, Mn, Ni and Pb Load on Soil and its enrichment factor ratios in different soil grain size fractions as an Indicator for soil pollution

    International Nuclear Information System (INIS)

    Rabie, F.H.; Abdel-Sabour, M.F.

    2000-01-01

    An industrial area north of greater Cairo was selected to investigate the impact of intensive industrial activities on soil characteristics and Fe, Mn, Ni and Pb total content. The studied area was divided to six sectors according to its source of irrigation water and/or probability of pollution. Sixteen soil profiles were dug and soil samples were taken, air dried, fractionated to different grain size fractions, then total heavy metals (Fe, Mn, Ni and Pb) were determined using ICP technique. The enrichment factor for each metal for each soil fraction/soil layer was estimated and discussed. The highest EF ratios in the clay fraction was mainly with Pb which indicated the industrial impact on the soil. In case of sand fraction, Mn was the highest always compared to other studied metals. Concerning silt fraction, a varied accumulation of Fe, Mn, and Pb was observed with soil depth and different soil profiles

  16. Strong Decomposition of Random Variables

    DEFF Research Database (Denmark)

    Hoffmann-Jørgensen, Jørgen; Kagan, Abram M.; Pitt, Loren D.

    2007-01-01

    A random variable X is stongly decomposable if X=Y+Z where Y=Φ(X) and Z=X-Φ(X) are independent non-degenerated random variables (called the components). It is shown that at least one of the components is singular, and we derive a necessary and sufficient condition for strong decomposability...... of a discrete random variable....

  17. Strong coupling electroweak symmetry breaking

    International Nuclear Information System (INIS)

    Barklow, T.L.; Burdman, G.; Chivukula, R.S.

    1997-04-01

    The authors review models of electroweak symmetry breaking due to new strong interactions at the TeV energy scale and discuss the prospects for their experimental tests. They emphasize the direct observation of the new interactions through high-energy scattering of vector bosons. They also discuss indirect probes of the new interactions and exotic particles predicted by specific theoretical models

  18. Strong coupling electroweak symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Barklow, T.L. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Burdman, G. [Univ. of Wisconsin, Madison, WI (United States). Dept. of Physics; Chivukula, R.S. [Boston Univ., MA (United States). Dept. of Physics

    1997-04-01

    The authors review models of electroweak symmetry breaking due to new strong interactions at the TeV energy scale and discuss the prospects for their experimental tests. They emphasize the direct observation of the new interactions through high-energy scattering of vector bosons. They also discuss indirect probes of the new interactions and exotic particles predicted by specific theoretical models.

  19. The colours of strong interaction

    International Nuclear Information System (INIS)

    1995-01-01

    The aim of this session is to draw a consistent framework about the different ways to consider strong interaction. A large part is dedicated to theoretical work and the latest experimental results obtained at the first electron collider HERA are discussed. (A.C.)

  20. Strong cosmic censorship and the strong curvature singularities

    International Nuclear Information System (INIS)

    Krolak, A.

    1987-01-01

    Conditions are given under which any asymptotically simple and empty space-time that has a partial Cauchy surface with an asymptotically simple past is globally hyperbolic. It is shown that this result suggests that the Cauchy horizons of the type occurring in Reissner--Nordstroem and Kerr space-times are unstable. This in turn gives support for the validity of the strong cosmic censorship hypothesis

  1. HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.

    Directory of Open Access Journals (Sweden)

    T Déirdre Hollingsworth

    2010-05-01

    Full Text Available It has been hypothesized that HIV-1 viral load set-point is a surrogate measure of HIV-1 viral virulence, and that it may be subject to natural selection in the human host population. A key test of this hypothesis is whether viral load set-points are correlated between transmitting individuals and those acquiring infection. We retrospectively identified 112 heterosexual HIV-discordant couples enrolled in a cohort in Rakai, Uganda, in which HIV transmission was suspected and viral load set-point was established. In addition, sequence data was available to establish transmission by genetic linkage for 57 of these couples. Sex, age, viral subtype, index partner, and self-reported genital ulcer disease status (GUD were known. Using ANOVA, we estimated the proportion of variance in viral load set-points which was explained by the similarity within couples (the 'couple effect'. Individuals with suspected intra-couple transmission (97 couples had similar viral load set-points (p = 0.054 single factor model, p = 0.0057 adjusted and the couple effect explained 16% of variance in viral loads (23% adjusted. The analysis was repeated for a subset of 29 couples with strong genetic support for transmission. The couple effect was the major determinant of viral load set-point (p = 0.067 single factor, and p = 0.036 adjusted and the size of the effect was 27% (37% adjusted. Individuals within epidemiologically linked couples with genetic support for transmission had similar viral load set-points. The most parsimonious explanation is that this is due to shared characteristics of the transmitted virus, a finding which sheds light on both the role of viral factors in HIV-1 pathogenesis and on the evolution of the virus.

  2. Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Science.gov (United States)

    Meier, Beat; Zimmermann, Thomas D.

    2015-01-01

    In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially. PMID:26082709

  3. Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory.

    Science.gov (United States)

    Meier, Beat; Zimmermann, Thomas D

    2015-01-01

    In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  4. Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Chiu-Yen Chung

    2017-03-01

    Full Text Available Brain derived neurotrophic factor (BDNF can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC was constructed to deliver plasmid DNAs (pDNAs containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF. The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting. The HRE-cmvBDNF appeared to adsorb onto the surface of PS80 PBCA NC, with a resultant mean diameter of 92.6 ± 1.0 nm and zeta potential of −14.1 ± 1.1 mV. HIF-1α level in iPSCs was significantly higher in hypoxia, which resulted in a 51% greater BDNF expression when transfected with PS80 PBCA NC/HRE-cmvBDNF than those without hypoxia. TrkB and phospho-Akt were also elevated which correlated with neural differentiation. The findings suggest that PS80 PBCA NC too can be endocytosed to serve as an efficient vector for genes coupled to the HRE in hypoxia-sensitive cells, and activation of the PI3/Akt pathway in iPSCs by BDNF is capable of neural lineage specification.

  5. Priority hazardous substances for the aquatic environment: critical evaluation of the emission factor method for the indirect estimate of the loads

    International Nuclear Information System (INIS)

    Azzellino, A.; Vismara, R.

    2005-01-01

    The European Water Framework Directive require to the EU Member States the knowledge of the priority hazardous pollutant contamination levels. Regional basin management plans (according to Italian laws D.Lgs 152/99 and to D.M. 367/03) generally include a review about the status of water contamination to respond to the Eu legislation prescriptions. However, since the actual monitoring activity of the water contamination is expensive and also extremely difficult in terms of analytical sensitivity, the most of these reviews has been prepared by using indirect emission coefficient estimates derived form literature. It is well known that such emission coefficients have been rarely proved fully reliable; moreover such an approach gives no information about the variability affecting the emission estimates. Aim of this work was to use the data contained into the emission EPER-INES database, european database which contains the IPPC Directive emission declarations, to define emission coefficients more reliable than literature coefficients. The presented results, even though based on a limited number of observations and referring the most only to heavy metals, confirm the scarce affidability of the emission factor method and show remarkable discrepancies (mostly under- but also over-estimations of about ten-fold) of these emission estimates from the actual emission data of the IPPC declarations. These results allow also to evaluate the not negligible variability that affects the definition of emission coefficients [it

  6. Diffraction analysis of materials under strong plastic deformation

    International Nuclear Information System (INIS)

    Pyzalla, A.

    2001-01-01

    The applicability of X-ray diffraction in analyses of the microstructure texture and intrinsic stresses of materials under strong plastic deformation is illustrated by examples and discussed. The experimental methods and findings are supplemented by numeric calculations. It is shown how the microstructure, texture and intrinsic stresses can thus be optimized already in the production process. Analyses of changes in materials during operation of a component provide information on loads and material response to loads which can then be used for optimization of the component, e.g. by constructional modifications or selective heat treatment [de

  7. Strong and electromagnetic interactions in hadron systems

    International Nuclear Information System (INIS)

    Aissat, N.; Amghar, A.; Cano, F.; Gonzalez, F.; Noguera, S.; Carbonell, J.; Desplanques, B.; Silvestre-Brac, B.; Karmanov, V.; Mathiot, J.F.

    1997-01-01

    The pionic strong decay amplitudes of baryon resonances are studied in a constituent quark model. Particular attention is given to the operator describing the transition. The nucleon form factors are calculated in a non-relativistic approach, with emphasis on the highest momentum transfers. The aim is to determine the ingredients that are essential in getting correct results and are likely to be required for a more realistic estimate in a fully relativistic approach. The deuteron form factors have been calculated in the light-front approach using wave functions determined in a perturbative way. The derivation of the neutron charge form factor from the deuteron structure function, A(q 2 ), is reanalyzed including further mesonic exchange contributions. (authors)

  8. Load forecasting method considering temperature effect for distribution network

    Directory of Open Access Journals (Sweden)

    Meng Xiao Fang

    2016-01-01

    Full Text Available To improve the accuracy of load forecasting, the temperature factor was introduced into the load forecasting in this paper. This paper analyzed the characteristics of power load variation, and researched the rule of the load with the temperature change. Based on the linear regression analysis, the mathematical model of load forecasting was presented with considering the temperature effect, and the steps of load forecasting were given. Used MATLAB, the temperature regression coefficient was calculated. Using the load forecasting model, the full-day load forecasting and time-sharing load forecasting were carried out. By comparing and analyzing the forecast error, the results showed that the error of time-sharing load forecasting method was small in this paper. The forecasting method is an effective method to improve the accuracy of load forecasting.

  9. Strongly Correlated Systems Theoretical Methods

    CERN Document Server

    Avella, Adolfo

    2012-01-01

    The volume presents, for the very first time, an exhaustive collection of those modern theoretical methods specifically tailored for the analysis of Strongly Correlated Systems. Many novel materials, with functional properties emerging from macroscopic quantum behaviors at the frontier of modern research in physics, chemistry and materials science, belong to this class of systems. Any technique is presented in great detail by its own inventor or by one of the world-wide recognized main contributors. The exposition has a clear pedagogical cut and fully reports on the most relevant case study where the specific technique showed to be very successful in describing and enlightening the puzzling physics of a particular strongly correlated system. The book is intended for advanced graduate students and post-docs in the field as textbook and/or main reference, but also for other researchers in the field who appreciates consulting a single, but comprehensive, source or wishes to get acquainted, in a as painless as po...

  10. Strongly correlated systems numerical methods

    CERN Document Server

    Mancini, Ferdinando

    2013-01-01

    This volume presents, for the very first time, an exhaustive collection of those modern numerical methods specifically tailored for the analysis of Strongly Correlated Systems. Many novel materials, with functional properties emerging from macroscopic quantum behaviors at the frontier of modern research in physics, chemistry and material science, belong to this class of systems. Any technique is presented in great detail by its own inventor or by one of the world-wide recognized main contributors. The exposition has a clear pedagogical cut and fully reports on the most relevant case study where the specific technique showed to be very successful in describing and enlightening the puzzling physics of a particular strongly correlated system. The book is intended for advanced graduate students and post-docs in the field as textbook and/or main reference, but also for other researchers in the field who appreciate consulting a single, but comprehensive, source or wishes to get acquainted, in a as painless as possi...

  11. Strongly correlated systems experimental techniques

    CERN Document Server

    Mancini, Ferdinando

    2015-01-01

    The continuous evolution and development of experimental techniques is at the basis of any fundamental achievement in modern physics. Strongly correlated systems (SCS), more than any other, need to be investigated through the greatest variety of experimental techniques in order to unveil and crosscheck the numerous and puzzling anomalous behaviors characterizing them. The study of SCS fostered the improvement of many old experimental techniques, but also the advent of many new ones just invented in order to analyze the complex behaviors of these systems. Many novel materials, with functional properties emerging from macroscopic quantum behaviors at the frontier of modern research in physics, chemistry and materials science, belong to this class of systems. The volume presents a representative collection of the modern experimental techniques specifically tailored for the analysis of strongly correlated systems. Any technique is presented in great detail by its own inventor or by one of the world-wide recognize...

  12. Flavour Democracy in Strong Unification

    CERN Document Server

    Abel, S A; Abel, Steven; King, Steven

    1998-01-01

    We show that the fermion mass spectrum may naturally be understood in terms of flavour democratic fixed points in supersymmetric theories which have a large domain of attraction in the presence of "strong unification". Our approach provides an alternative to the approximate Yukawa texture zeroes of the Froggatt-Nielsen mechanism. We discuss a particular model based on a broken gauged $SU(3)_L\\times SU(3)_R$ family symmetry which illustrates our approach.

  13. String dynamics at strong coupling

    International Nuclear Information System (INIS)

    Hull, C.M.

    1996-01-01

    The dynamics of superstring, supergravity and M-theories and their compactifications are probed by studying the various perturbation theories that emerge in the strong and weak-coupling limits for various directions in coupling constant space. The results support the picture of an underlying non-perturbative theory that, when expanded perturbatively in different coupling constants, gives different perturbation theories, which can be perturbative superstring theories or superparticle theories. The p-brane spectrum is considered in detail and a criterion found to establish which p-branes govern the strong-coupling dynamics. In many cases there are competing conjectures in the literature, and this analysis decides between them. In other cases, new results are found. The chiral 6-dimensional theory resulting from compactifying the type IIB string on K 3 is studied in detail and it is found that certain strong-coupling limits appear to give new theories, some of which hint at the possibility of a 12-dimensional origin. (orig.)

  14. Economic impact analysis of load forecasting

    International Nuclear Information System (INIS)

    Ranaweera, D.K.; Karady, G.G.; Farmer, R.G.

    1997-01-01

    Short term load forecasting is an essential function in electric power system operations and planning. Forecasts are needed for a variety of utility activities such as generation scheduling, scheduling of fuel purchases, maintenance scheduling and security analysis. Depending on power system characteristics, significant forecasting errors can lead to either excessively conservative scheduling or very marginal scheduling. Either can induce heavy economic penalties. This paper examines the economic impact of inaccurate load forecasts. Monte Carlo simulations were used to study the effect of different load forecasting accuracy. Investigations into the effect of improving the daily peak load forecasts, effect of different seasons of the year and effect of utilization factors are presented

  15. Wind Loads on Structures

    DEFF Research Database (Denmark)

    Dyrbye, Claes; Hansen, Svend Ole

    Wind loads have to be taken into account when designing civil engineering structures. The wind load on structures can be systematised by means of the wind load chain: wind climate (global), terrain (wind at low height), aerodynamic response (wind load to pressure), mechanical response (wind...... pressure to structural response) and design criteria. Starting with an introduction of the wind load chain, the book moves on to meteorological considerations, atmospheric boundary layer, static wind load, dynamic wind load and scaling laws used in wind-tunnel tests. The dynamic wind load covers vibrations...... induced by wind turbulence, vortex shedding, flutter and galloping. The book gives a comprehensive treatment of wind effects on structures and it will be useful for consulting engineers designing wind-sensitive structures. It will also be valuable for students of civil engineering as textbook...

  16. Carbohydrate-Loading Diet

    Science.gov (United States)

    ... Grape juice (12 ounces) 55 225 Lunch Milk, chocolate, reduced fat (12 ounces) 45 285 4 slices ... usual during carbohydrate loading to get the same benefits as a man does. Despite carbohydrate loading, you ...

  17. Autonomous Propellant Loading Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Autonomous Propellant Loading (APL) project consists of three activities. The first is to develop software that will automatically control loading of...

  18. Fuel pellet loading apparatus

    International Nuclear Information System (INIS)

    1980-01-01

    Apparatus is described for loading a predetermined amount of nuclear fuel pellets into nuclear fuel elements and particularly for the automatic loading of fuel pellets from within a sealed compartment. (author)

  19. Diffusion Indexes with Sparse Loadings

    DEFF Research Database (Denmark)

    Kristensen, Johannes Tang

    The use of large-dimensional factor models in forecasting has received much attention in the literature with the consensus being that improvements on forecasts can be achieved when comparing with standard models. However, recent contributions in the literature have demonstrated that care needs...... to the problem by using the LASSO as a variable selection method to choose between the possible variables and thus obtain sparse loadings from which factors or diffusion indexes can be formed. This allows us to build a more parsimonious factor model which is better suited for forecasting compared...... it to be an important alternative to PC....

  20. PREFACE: Strongly correlated electron systems Strongly correlated electron systems

    Science.gov (United States)

    Saxena, Siddharth S.; Littlewood, P. B.

    2012-07-01

    This special section is dedicated to the Strongly Correlated Electron Systems Conference (SCES) 2011, which was held from 29 August-3 September 2011, in Cambridge, UK. SCES'2011 is dedicated to 100 years of superconductivity and covers a range of topics in the area of strongly correlated systems. The correlated electronic and magnetic materials featured include f-electron based heavy fermion intermetallics and d-electron based transition metal compounds. The selected papers derived from invited presentations seek to deepen our understanding of the rich physical phenomena that arise from correlation effects. The focus is on quantum phase transitions, non-Fermi liquid phenomena, quantum magnetism, unconventional superconductivity and metal-insulator transitions. Both experimental and theoretical work is presented. Based on fundamental advances in the understanding of electronic materials, much of 20th century materials physics was driven by miniaturisation and integration in the electronics industry to the current generation of nanometre scale devices. The achievements of this industry have brought unprecedented advances to society and well-being, and no doubt there is much further to go—note that this progress is founded on investments and studies in the fundamentals of condensed matter physics from more than 50 years ago. Nevertheless, the defining challenges for the 21st century will lie in the discovery in science, and deployment through engineering, of technologies that can deliver the scale needed to have an impact on the sustainability agenda. Thus the big developments in nanotechnology may lie not in the pursuit of yet smaller transistors, but in the design of new structures that can revolutionise the performance of solar cells, batteries, fuel cells, light-weight structural materials, refrigeration, water purification, etc. The science presented in the papers of this special section also highlights the underlying interest in energy-dense materials, which

  1. Limit loads in nozzles

    International Nuclear Information System (INIS)

    Zouain, N.

    1983-01-01

    The static method for the evaluation of the limit loads of a perfectly elasto-plastic structure is presented. Using the static theorem of Limit Analysis and the Finite Element Method, a lower bound for the colapso load can be obtained through a linear programming problem. This formulation if then applied to symmetrically loaded shells of revolution and some numerical results of limit loads in nozzles are also presented. (Author) [pt

  2. Friction and anchorage loading revisited.

    Science.gov (United States)

    Dholakia, Kartik D

    2012-01-01

    Contemporary concepts of sliding mechanics explain that friction is inevitable. To overcome this frictional resistance, excess force is required to retract the tooth along the archwire (ie, individual retraction of canines, en masse retraction of anterior teeth), in addition to the amount of force required for tooth movement. The anterior tooth retraction force, in addition to excess force (to overcome friction), produces reciprocal protraction force on molars, thereby leading to increased anchorage loading. However, this traditional concept was challenged in recent literature, which was based on the finite element model, but did not bear correlation to the clinical scenario. This article will reinforce the fact that clinically, friction increases anchorage loading in all three planes of space, considering the fact that tooth movement is a quasistatic process rather than a purely continuous or static one, and that conventional ways of determining the effects of static or dynamic friction on anchorage load cannot be applied to clinical situations (which consist of anatomical resistance units and a complex muscular force system). The article does not aim to quantify friction and its effect on the amount of anchorage load. Rather, a new perspective regarding the role of various additional factors (which is not explained by contemporary concept) that may influence friction and anchorage loading is provided..

  3. Atoms in strong laser fields

    International Nuclear Information System (INIS)

    L'Huillier, A.

    2002-01-01

    When a high-power laser focuses into a gas of atoms, the electromagnetic field becomes of the same magnitude as the Coulomb field which binds a 1s electron in a hydrogen atom. 3 highly non-linear phenomena can happen: 1) ATI (above threshold ionization): electrons initially in the ground state absorb a large number of photons, many more than the minimum number required for ionization; 2) multiple ionization: many electrons can be emitted one at a time, in a sequential process, or simultaneously in a mechanism called direct or non-sequential; and 3) high order harmonic generation (HHG): efficient photon emission in the extreme ultraviolet range, in the form of high-order harmonics of the fundamental laser field can occur. The theoretical problem consists in solving the time dependent Schroedinger equation (TDSE) that describes the interaction of a many-electron atom with a laser field. A number of methods have been proposed to solve this problem in the case of a hydrogen atom or a single-active electron atom in a strong laser field. A large effort is presently being devoted to go beyond the single-active approximation. The understanding of the physics of the interaction between atoms and strong laser fields has been provided by a very simple model called ''simple man's theory''. A unified view of HHG, ATI, and non-sequential ionization, originating from the simple man's model and the strong field approximation, expressed in terms of electrons trajectories or quantum paths is slowly emerging. (A.C.)

  4. Rydberg atoms in strong fields

    International Nuclear Information System (INIS)

    Kleppner, D.; Tsimmerman, M.

    1985-01-01

    Experimental and theoretical achievements in studying Rydberg atoms in external fields are considered. Only static (or quasistatic) fields and ''one-electron'' atoms, i.e. atoms that are well described by one-electron states, are discussed. Mainly behaviour of alkali metal atoms in electric field is considered. The state of theoretical investigations for hydrogen atom in magnetic field is described, but experimental data for atoms of alkali metals are presented as an illustration. Results of the latest experimental and theoretical investigations into the structure of Rydberg atoms in strong fields are presented

  5. Strongly interacting light dark matter

    International Nuclear Information System (INIS)

    Bruggisser, Sebastian; Riva, Francesco; Urbano, Alfredo

    2016-07-01

    In the presence of approximate global symmetries that forbid relevant interactions, strongly coupled light Dark Matter (DM) can appear weakly coupled at small-energy and generate a sizable relic abundance. Fundamental principles like unitarity restrict these symmetries to a small class, where the leading interactions are captured by effective operators up to dimension-8. Chiral symmetry, spontaneously broken global symmetries and non-linearly realized supersymmetry are examples of this. Their DM candidates (composite fermions, pseudo-Nambu-Goldstone Bosons and Goldstini) are interesting targets for LHC missing-energy searches.

  6. Weak consistency and strong paraconsistency

    Directory of Open Access Journals (Sweden)

    Gemma Robles

    2009-11-01

    Full Text Available In a standard sense, consistency and paraconsistency are understood as, respectively, the absence of any contradiction and as the absence of the ECQ (“E contradictione quodlibet” rule that allows us to conclude any well formed formula from any contradiction. The aim of this paper is to explain the concepts of weak consistency alternative to the standard one, the concepts of paraconsistency related to them and the concept of strong paraconsistency, all of which have been defined by the author together with José M. Méndez.

  7. On the strong CP problem

    Energy Technology Data Exchange (ETDEWEB)

    Dowrick, N.J. (Dept. of Physics, Oxford (United Kingdom)); McDougall, N.A. (National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan))

    1992-07-09

    We show that two well-known solutions to the strong CP problem, the axion and a massless quark, may be understood in terms of the mechanism recently proposed by Samuel where long-range interactions between topological charges may be responsible for the removal of CP violation. We explain how the axion and a QCD meson (identified as the {eta}' if all quarks are massless) suppress fluctuations in global topological charge by almost identical dynamical although the masses, couplings and relevant length scales are very different. Furthermore, we elucidate the precise origin of the {eta}' mass. (orig.).

  8. Scalar strong interaction hadron theory

    CERN Document Server

    Hoh, Fang Chao

    2015-01-01

    The scalar strong interaction hadron theory, SSI, is a first principles' and nonlocal theory at quantum mechanical level that provides an alternative to low energy QCD and Higgs related part of the standard model. The quark-quark interaction is scalar rather than color-vectorial. A set of equations of motion for mesons and another set for baryons have been constructed. This book provides an account of the present state of a theory supposedly still at its early stage of development. This work will facilitate researchers interested in entering into this field and serve as a basis for possible future development of this theory.

  9. Estimation of strong ground motion

    International Nuclear Information System (INIS)

    Watabe, Makoto

    1993-01-01

    Fault model has been developed to estimate a strong ground motion in consideration of characteristics of seismic source and propagation path of seismic waves. There are two different approaches in the model. The first one is a theoretical approach, while the second approach is a semi-empirical approach. Though the latter is more practical than the former to be applied to the estimation of input motions, it needs at least the small-event records, the value of the seismic moment of the small event and the fault model of the large event

  10. Strong Mechanoluminescence from Oxynitridosilicate Phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Lin; Xu Chaonan; Yamada, Hiroshi, E-mail: cn-xu@aist.go.jp [National Institute of Advanced Industrial Science and Technology (AIST), 807-1 Shuku, Tosu, Saga 841-0052 (Japan)

    2011-10-29

    We successfully developed a novel Mechanoluminescence (ML) material with water resistance, oxynitridosilicate; BaSi{sub 2}O{sub 2}N{sub 2}: Eu{sup 2+}. The crystal structure, photoluminescence (PL) and ML properties were characterized. The ML of BaSi{sub 2}O{sub 2}N{sub 2}: Eu{sup 2+} is so strong that the blue-green emission can be observed by the naked eyes clearly. In addition, it shows superior water resistance property. No changes were found in the ML intensities during the total water treatment test.

  11. Spatial analysis of instream nitrogen loads and factors controlling nitrogen delivery to streams in the southeastern United States using spatially referenced regression on watershed attributes (SPARROW) and regional classification frameworks

    Science.gov (United States)

    Hoos, Anne B.; McMahon, Gerard

    2009-01-01

    Understanding how nitrogen transport across the landscape varies with landscape characteristics is important for developing sound nitrogen management policies. We used a spatially referenced regression analysis (SPARROW) to examine landscape characteristics influencing delivery of nitrogen from sources in a watershed to stream channels. Modelled landscape delivery ratio varies widely (by a factor of 4) among watersheds in the southeastern United States—higher in the western part (Tennessee, Alabama, and Mississippi) than in the eastern part, and the average value for the region is lower compared to other parts of the nation. When we model landscape delivery ratio as a continuous function of local-scale landscape characteristics, we estimate a spatial pattern that varies as a function of soil and climate characteristics but exhibits spatial structure in residuals (observed load minus predicted load). The spatial pattern of modelled landscape delivery ratio and the spatial pattern of residuals coincide spatially with Level III ecoregions and also with hydrologic landscape regions. Subsequent incorporation into the model of these frameworks as regional scale variables improves estimation of landscape delivery ratio, evidenced by reduced spatial bias in residuals, and suggests that cross-scale processes affect nitrogen attenuation on the landscape. The model-fitted coefficient values are logically consistent with the hypothesis that broad-scale classifications of hydrologic response help to explain differential rates of nitrogen attenuation, controlling for local-scale landscape characteristics. Negative model coefficients for hydrologic landscape regions where the primary flow path is shallow ground water suggest that a lower fraction of nitrogen mass will be delivered to streams; this relation is reversed for regions where the primary flow path is overland flow.

  12. Mixtures of Strongly Interacting Bosons in Optical Lattices

    International Nuclear Information System (INIS)

    Buonsante, P.; Penna, V.; Giampaolo, S. M.; Illuminati, F.; Vezzani, A.

    2008-01-01

    We investigate the properties of strongly interacting heteronuclear boson-boson mixtures loaded in realistic optical lattices, with particular emphasis on the physics of interfaces. In particular, we numerically reproduce the recent experimental observation that the addition of a small fraction of 41 K induces a significant loss of coherence in 87 Rb, providing a simple explanation. We then investigate the robustness against the inhomogeneity typical of realistic experimental realizations of the glassy quantum emulsions recently predicted to occur in strongly interacting boson-boson mixtures on ideal homogeneous lattices

  13. Nonlinear charge reduction effect in strongly coupled plasmas

    International Nuclear Information System (INIS)

    Sarmah, D; Tessarotto, M; Salimullah, M

    2006-01-01

    The charge reduction effect, produced by the nonlinear Debye screening of high-Z charges occurring in strongly coupled plasmas, is investigated. An analytic asymptotic expression is obtained for the charge reduction factor (f c ) which determines the Debye-Hueckel potential generated by a charged test particle. Its relevant parametric dependencies are analysed and shown to predict a strong charge reduction effect in strongly coupled plasmas

  14. Effective lagrangian for strong interactions

    International Nuclear Information System (INIS)

    Jain, P.

    1988-01-01

    We attempt to construct a realistic phenomenological Lagrangian in order to describe strong interactions. This is in general a very complicated problem and we shall explore its various aspects. We first include the vector mesons by writing down the most general chiral invariant terms proportional to the Levi-Civita symbol ε μναβ . These terms involve three unknown coefficients, which are calculated by using the experimental results of strong interaction processes. We then calculate the static nucleon properties by finding the solitonic excitations of this model. The results turn out to be, as is also the case for most other vector-pseudoscalar Lagrangians, better than the Skyrme model but are still somewhat different from the experiments. Another aspect that we shall study is the incorporation of scale anomaly of QCD into the Skyrme model. We thus introduce a scalar glueball in our Lagrangian. Here we find an interesting result that the effective glue field dynamically forms a bag for the soliton. Depending on the values of the parameters, we get either a deep bag or a shallow bag. However by including the scalar meson, we find that to get realistic scalar sector we must have the shallow bag. Finally we show some intriguing connections between the chiral quark model, in which the nucleon is described as a solitonic excitation, and the ordinary potential binding quark model

  15. EDITORIAL: Strongly correlated electron systems Strongly correlated electron systems

    Science.gov (United States)

    Ronning, Filip; Batista, Cristian

    2011-03-01

    Strongly correlated electrons is an exciting and diverse field in condensed matter physics. This special issue aims to capture some of that excitement and recent developments in the field. Given that this issue was inspired by the 2010 International Conference on Strongly Correlated Electron Systems (SCES 2010), we briefly give some history in order to place this issue in context. The 2010 International Conference on Strongly Correlated Electron Systems was held in Santa Fe, New Mexico, a reunion of sorts from the 1989 International Conference on the Physics of Highly Correlated Electron Systems that also convened in Santa Fe. SCES 2010—co-chaired by John Sarrao and Joe Thompson—followed the tradition of earlier conferences, in this century, hosted by Buzios (2008), Houston (2007), Vienna (2005), Karlsruhe (2004), Krakow (2002) and Ann Arbor (2001). Every three years since 1997, SCES has joined the International Conference on Magnetism (ICM), held in Recife (2000), Rome (2003), Kyoto (2006) and Karlsruhe (2009). Like its predecessors, SCES 2010 topics included strongly correlated f- and d-electron systems, heavy-fermion behaviors, quantum-phase transitions, non-Fermi liquid phenomena, unconventional superconductivity, and emergent states that arise from electronic correlations. Recent developments from studies of quantum magnetism and cold atoms complemented the traditional subjects and were included in SCES 2010. 2010 celebrated the 400th anniversary of Santa Fe as well as the birth of astronomy. So what's the connection to SCES? The Dutch invention of the first practical telescope and its use by Galileo in 1610 and subsequent years overturned dogma that the sun revolved about the earth. This revolutionary, and at the time heretical, conclusion required innovative combinations of new instrumentation, observation and mathematics. These same combinations are just as important 400 years later and are the foundation of scientific discoveries that were discussed

  16. Strong Selective Adsorption of Polymers.

    Science.gov (United States)

    Ge, Ting; Rubinstein, Michael

    2015-06-09

    A scaling theory is developed for selective adsorption of polymers induced by the strong binding between specific monomers and complementary surface adsorption sites. By "selective" we mean specific attraction between a subset of all monomers, called "sticky", and a subset of surface sites, called "adsorption sites". We demonstrate that, in addition to the expected dependence on the polymer volume fraction ϕ bulk in the bulk solution, selective adsorption strongly depends on the ratio between two characteristic length scales, the root-mean-square distance l between neighboring sticky monomers along the polymer, and the average distance d between neighboring surface adsorption sites. The role of the ratio l / d arises from the fact that a polymer needs to deform to enable the spatial commensurability between its sticky monomers and the surface adsorption sites for selective adsorption. We study strong selective adsorption of both telechelic polymers with two end monomers being sticky and multisticker polymers with many sticky monomers between sticky ends. For telechelic polymers, we identify four adsorption regimes at l / d 1, we expect that the adsorption layer at exponentially low ϕ bulk consists of separated unstretched loops, while as ϕ bulk increases the layer crosses over to a brush of extended loops with a second layer of weakly overlapping tails. For multisticker chains, in the limit of exponentially low ϕ bulk , adsorbed polymers are well separated from each other. As l / d increases, the conformation of an individual polymer changes from a single-end-adsorbed "mushroom" to a random walk of loops. For high ϕ bulk , adsorbed polymers at small l / d are mushrooms that cover all the adsorption sites. At sufficiently large l / d , adsorbed multisticker polymers strongly overlap. We anticipate the formation of a self-similar carpet and with increasing l / d a two-layer structure with a brush of loops covered by a self-similar carpet. As l / d exceeds the

  17. Spatial electric load forecasting

    CERN Document Server

    Willis, H Lee

    2002-01-01

    Spatial Electric Load Forecasting Consumer Demand for Power and ReliabilityCoincidence and Load BehaviorLoad Curve and End-Use ModelingWeather and Electric LoadWeather Design Criteria and Forecast NormalizationSpatial Load Growth BehaviorSpatial Forecast Accuracy and Error MeasuresTrending MethodsSimulation Method: Basic ConceptsA Detailed Look at the Simulation MethodBasics of Computerized SimulationAnalytical Building Blocks for Spatial SimulationAdvanced Elements of Computerized SimulationHybrid Trending-Simulation MethodsAdvanced

  18. Cognitive Load and Cooperation

    DEFF Research Database (Denmark)

    Døssing, Felix Sebastian; Piovesan, Marco; Wengström, Erik Roland

    2017-01-01

    We study the effect of intuitive and reflective processes on cooperation using cognitive load. Compared with time constraint, which has been used in the previous literature, cognitive load is a more direct way to block reflective processes, and thus a more suitable way to study the link between...... intuition and cooperation. Using a repeated public goods game, we study the effect of different levels of cognitive load on contributions. We show that a higher cognitive load increases the initial level of cooperation. In particular, subjects are significantly less likely to fully free ride under high...... cognitive load....

  19. Fuel cladding behavior under rapid loading conditions

    Science.gov (United States)

    Yueh, K.; Karlsson, J.; Stjärnsäter, J.; Schrire, D.; Ledergerber, G.; Munoz-Reja, C.; Hallstadius, L.

    2016-02-01

    A modified burst test (MBT) was used in an extensive test program to characterize fuel cladding failure behavior under rapid loading conditions. The MBT differs from a normal burst test with the use of a driver tube to simulate the expansion of a fuel pellet, thereby producing a partial strain driven deformation condition similar to that of a fuel pellet expansion in a reactivity insertion accident (RIA). A piston/cylinder assembly was used to pressurize the driver tube. By controlling the speed and distance the piston travels the loading rate and degree of sample deformation could be controlled. The use of a driver tube with a machined gauge section localizes deformation and allows for continuous monitoring of the test sample diameter change at the location of maximum hoop strain, during each test. Cladding samples from five irradiated fuel rods were tested between 296 and 553 K and loading rates from 1.5 to 3.5/s. The test rods included variations of Zircaloy-2 with different liners and ZIRLO, ranging in burn-up from 41 to 74 GWd/MTU. The test results show cladding ductility is strongly temperature and loading rate dependent. Zircaloy-2 cladding ductility degradation due to operational hydrogen pickup started to recover at approximately 358 K for test condition used in the study. This recovery temperature is strongly loading rate dependent. At 373 K, ductility recovery was small for loading rates less than 8 ms equivalent RIA pulse width, but longer than 8 ms the ductility recovery increased exponentially with increasing pulse width, consistent with literature observations of loading rate dependent brittle-to-ductile (BTD) transition temperature. The cladding ductility was also observed to be strongly loading rate/pulse width dependent for BWR cladding below the BTD temperature and Pressurized Water Reactor (PWR) cladding at both 296 and 553 K.

  20. Strong Interactions, (De)coherence and Quarkonia

    CERN Document Server

    Bellucci, Stefano; Tiwari, Bhupendra Nath

    2011-01-01

    Quarkonia are the central objects to explore the non-perturbative nature of non-abelian gauge theories. We describe the confinement-deconfinement phases for heavy quarkonia in a hot QCD medium and thereby the statistical nature of the inter-quark forces. In the sense of one-loop quantum effects, we propose that the "quantum" nature of quark matters follows directly from the thermodynamic consideration of Richardson potential. Thereby we gain an understanding of the formation of hot and dense states of quark gluon plasma matter in heavy ion collisions and the early universe. In the case of the non-abelian theory, the consideration of the Sudhakov form factor turns out to be an efficient tool for soft gluons. In the limit of the Block-Nordsieck resummation, the strong coupling obtained from the Sudhakov form factor yields the statistical nature of hadronic bound states, e.g. kaons and Ds particles.

  1. Strong moduli stabilization and phenomenology

    CERN Document Server

    Dudas, Emilian; Mambrini, Yann; Mustafayev, Azar; Olive, Keith A

    2013-01-01

    We describe the resulting phenomenology of string theory/supergravity models with strong moduli stabilization. The KL model with F-term uplifting, is one such example. Models of this type predict universal scalar masses equal to the gravitino mass. In contrast, A-terms receive highly suppressed gravity mediated contributions. Under certain conditions, the same conclusion is valid for gaugino masses, which like A-terms, are then determined by anomalies. In such models, we are forced to relatively large gravitino masses (30-1000 TeV). We compute the low energy spectrum as a function of m_{3/2}. We see that the Higgs masses naturally takes values between 125-130 GeV. The lower limit is obtained from the requirement of chargino masses greater than 104 GeV, while the upper limit is determined by the relic density of dark matter (wino-like).

  2. Strongly interacting W's and Z's

    International Nuclear Information System (INIS)

    Gaillard, M.K.

    1984-01-01

    The study focussed primarily on the dynamics of a strongly interacting W, Z(SIW) sector, with the aim of sharpening predictions for total W, Z yield and W, Z multiplicities expected from WW fusion for various scenarios. Specific issues raised in the context of the general problem of modeling SIW included the specificity of the technicolor (or, equivalently, QCD) model, whether or not a composite scalar model can be evaded, and whether the standard model necessarily implies an I = J = O state (≅ Higgs particle) that is relatively ''light'' (M ≤ hundreds of TeV). The consensus on the last issue was that existing arguments are inconclusive. While the author shall briefly address compositeness and alternatives to the technicolor model, quantitative estimates will be of necessity based on technicolor or an extrapolation of pion data

  3. Uniquely Strongly Clean Group Rings

    Institute of Scientific and Technical Information of China (English)

    WANG XIU-LAN

    2012-01-01

    A ring R is called clean if every element is the sum of an idempotent and a unit,and R is called uniquely strongly clean (USC for short) if every element is uniquely the sum of an idempotent and a unit that commute.In this article,some conditions on a ring R and a group G such that RG is clean are given.It is also shown that if G is a locally finite group,then the group ring RG is USC if and only if R is USC,and G is a 2-group.The left uniquely exchange group ring,as a middle ring of the uniquely clean ring and the USC ring,does not possess this property,and so does the uniquely exchange group ring.

  4. Electrophoresis in strong electric fields.

    Science.gov (United States)

    Barany, Sandor

    2009-01-01

    Two kinds of non-linear electrophoresis (ef) that can be detected in strong electric fields (several hundred V/cm) are considered. The first ("classical" non-linear ef) is due to the interaction of the outer field with field-induced ionic charges in the electric double layer (EDL) under conditions, when field-induced variations of electrolyte concentration remain to be small comparatively to its equilibrium value. According to the Shilov theory, the non-linear component of the electrophoretic velocity for dielectric particles is proportional to the cubic power of the applied field strength (cubic electrophoresis) and to the second power of the particles radius; it is independent of the zeta-potential but is determined by the surface conductivity of particles. The second one, the so-called "superfast electrophoresis" is connected with the interaction of a strong outer field with a secondary diffuse layer of counterions (space charge) that is induced outside the primary (classical) diffuse EDL by the external field itself because of concentration polarization. The Dukhin-Mishchuk theory of "superfast electrophoresis" predicts quadratic dependence of the electrophoretic velocity of unipolar (ionically or electronically) conducting particles on the external field gradient and linear dependence on the particle's size in strong electric fields. These are in sharp contrast to the laws of classical electrophoresis (no dependence of V(ef) on the particle's size and linear dependence on the electric field gradient). A new method to measure the ef velocity of particles in strong electric fields is developed that is based on separation of the effects of sedimentation and electrophoresis using videoimaging and a new flowcell and use of short electric pulses. To test the "classical" non-linear electrophoresis, we have measured the ef velocity of non-conducting polystyrene, aluminium-oxide and (semiconductor) graphite particles as well as Saccharomice cerevisiae yeast cells as a

  5. Probabilistic model of bridge vehicle loads in port area based on in-situ load testing

    Science.gov (United States)

    Deng, Ming; Wang, Lei; Zhang, Jianren; Wang, Rei; Yan, Yanhong

    2017-11-01

    Vehicle load is an important factor affecting the safety and usability of bridges. An statistical analysis is carried out in this paper to investigate the vehicle load data of Tianjin Haibin highway in Tianjin port of China, which are collected by the Weigh-in- Motion (WIM) system. Following this, the effect of the vehicle load on test bridge is calculated, and then compared with the calculation result according to HL-93(AASHTO LRFD). Results show that the overall vehicle load follows a distribution with a weighted sum of four normal distributions. The maximum vehicle load during the design reference period follows a type I extremum distribution. The vehicle load effect also follows a weighted sum of four normal distributions, and the standard value of the vehicle load is recommended as 1.8 times that of the calculated value according to HL-93.

  6. The Factors of Soldier’s Load

    Science.gov (United States)

    1994-06-03

    turtles . My ruck weighed 120 pounds. American Airborne Soldier Grenada, 1983 One of the tenets of Army doctrine in Field Manual 100-5 QIp.r.aition•. is...from a lack of the appropriate physical conditioning in some units; and the more nebulous problem of insufficient logistical challenges built into

  7. Simulation of reinforced concrete short shear wall subjected to cyclic loading

    International Nuclear Information System (INIS)

    Parulekar, Y.M.; Reddy, G.R.; Vaze, K.K.; Pegon, P.; Wenzel, H.

    2014-01-01

    Highlights: • Prediction of the capacity of squat shear wall using tests and analysis. • Modification of model of concrete in the softening part. • Pushover analysis using softened truss theory and FE analysis is performed. • Modified concrete model gives reasonable accurate peak load and displacement. • The ductility, ultimate load and also crack pattern can be accurately predicted. - Abstract: This paper addresses the strength and deformation capacity of stiff squat shear wall subjected to monotonic and pseudo-static cyclic loading using experiments and analysis. Reinforced concrete squat shear walls offer great potential for lateral load resistance and the failure mode of these shear walls is brittle shear mode. Shear strength of these shear walls depend strongly on softening of concrete struts in principal compression direction due to principal tension in other direction. In this work simulation of the behavior of a squat shear wall is accurately predicted by finite element modeling by incorporating the appropriate softening model in the program. Modification of model of concrete in the softening part is suggested and reduction factor given by Vecchio et al. (1994) is used in the model. The accuracy of modeling is confirmed by comparing the simulated response with experimental one. The crack pattern generated from the 3D model is compared with that obtained from experiments. The load deflection for monotonic loads is also obtained using softened truss theory and compared with experimental one

  8. The DEMO wall load challenge

    Czech Academy of Sciences Publication Activity Database

    Wenninger, R.; Albanese, R.; Ambrosino, R.; Arbeiter, F.; Aubert, J.; Bachmann, C.; Barbato, L.; Barrett, T.; Beckers, M.; Biel, W.; Boccaccini, L.; Carralero, D.; Coster, D.; Eich, T.; Fasoli, A.; Federici, G.; Firdaouss, M.; Graves, J.; Horáček, Jan; Kovari, M.; Lanthaler, S.; Loschiavo, V.; Lowry, C.; Lux, H.; Maddaluno, G.; Maviglia, F.; Mitteau, R.; Neu, R.; Pfefferle, D.; Schmid, K.; Siccinio, M.; Sieglin, B.; Silva, C.; Snicker, A.; Subba, F.; Varje, J.; Zohm, H.

    2017-01-01

    Roč. 57, č. 4 (2017), č. článku 046002. ISSN 0029-5515 EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : DEMO * power loads * first wall Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 3.307, year: 2016 http://iopscience.iop.org/article/10.1088/1741-4326/aa4fb4

  9. Storm loads of culturable and molecular fecal indicators in an inland urban stream.

    Science.gov (United States)

    Liao, Hehuan; Krometis, Leigh-Anne H; Cully Hession, W; Benitez, Romina; Sawyer, Richard; Schaberg, Erin; von Wagoner, Emily; Badgley, Brian D

    2015-10-15

    Elevated concentrations of fecal indicator bacteria in receiving waters during wet-weather flows are a considerable public health concern that is likely to be exacerbated by future climate change and urbanization. Knowledge of factors driving the fate and transport of fecal indicator bacteria in stormwater is limited, and even less is known about molecular fecal indicators, which may eventually supplant traditional culturable indicators. In this study, concentrations and loading rates of both culturable and molecular fecal indicators were quantified throughout six storm events in an instrumented inland urban stream. While both concentrations and loading rates of each fecal indicator increased rapidly during the rising limb of the storm hydrographs, it is the loading rates rather than instantaneous concentrations that provide a better estimate of transport through the stream during the entire storm. Concentrations of general fecal indicators (both culturable and molecular) correlated most highly with each other during storm events but not with the human-associated HF183 Bacteroides marker. Event loads of general fecal indicators most strongly correlated with total runoff volume, maximum discharge, and maximum turbidity, while event loads of HF183 most strongly correlated with the time to peak flow in a hydrograph. These observations suggest that collection of multiple samples during a storm event is critical for accurate predictions of fecal indicator loading rates and total loads during wet-weather flows, which are required for effective watershed management. In addition, existing predictive models based on general fecal indicators may not be sufficient to predict source-specific genetic markers of fecal contamination. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Optimisation of load control

    International Nuclear Information System (INIS)

    Koponen, P.

    1998-01-01

    Electricity cannot be stored in large quantities. That is why the electricity supply and consumption are always almost equal in large power supply systems. If this balance were disturbed beyond stability, the system or a part of it would collapse until a new stable equilibrium is reached. The balance between supply and consumption is mainly maintained by controlling the power production, but also the electricity consumption or, in other words, the load is controlled. Controlling the load of the power supply system is important, if easily controllable power production capacity is limited. Temporary shortage of capacity causes high peaks in the energy price in the electricity market. Load control either reduces the electricity consumption during peak consumption and peak price or moves electricity consumption to some other time. The project Optimisation of Load Control is a part of the EDISON research program for distribution automation. The following areas were studied: Optimization of space heating and ventilation, when electricity price is time variable, load control model in power purchase optimization, optimization of direct load control sequences, interaction between load control optimization and power purchase optimization, literature on load control, optimization methods and field tests and response models of direct load control and the effects of the electricity market deregulation on load control. An overview of the main results is given in this chapter

  11. Optimisation of load control

    Energy Technology Data Exchange (ETDEWEB)

    Koponen, P [VTT Energy, Espoo (Finland)

    1998-08-01

    Electricity cannot be stored in large quantities. That is why the electricity supply and consumption are always almost equal in large power supply systems. If this balance were disturbed beyond stability, the system or a part of it would collapse until a new stable equilibrium is reached. The balance between supply and consumption is mainly maintained by controlling the power production, but also the electricity consumption or, in other words, the load is controlled. Controlling the load of the power supply system is important, if easily controllable power production capacity is limited. Temporary shortage of capacity causes high peaks in the energy price in the electricity market. Load control either reduces the electricity consumption during peak consumption and peak price or moves electricity consumption to some other time. The project Optimisation of Load Control is a part of the EDISON research program for distribution automation. The following areas were studied: Optimization of space heating and ventilation, when electricity price is time variable, load control model in power purchase optimization, optimization of direct load control sequences, interaction between load control optimization and power purchase optimization, literature on load control, optimization methods and field tests and response models of direct load control and the effects of the electricity market deregulation on load control. An overview of the main results is given in this chapter

  12. Comparison of Deterministic and Probabilistic Radial Distribution Systems Load Flow

    Science.gov (United States)

    Gupta, Atma Ram; Kumar, Ashwani

    2017-12-01

    Distribution system network today is facing the challenge of meeting increased load demands from the industrial, commercial and residential sectors. The pattern of load is highly dependent on consumer behavior and temporal factors such as season of the year, day of the week or time of the day. For deterministic radial distribution load flow studies load is taken as constant. But, load varies continually with a high degree of uncertainty. So, there is a need to model probable realistic load. Monte-Carlo Simulation is used to model the probable realistic load by generating random values of active and reactive power load from the mean and standard deviation of the load and for solving a Deterministic Radial Load Flow with these values. The probabilistic solution is reconstructed from deterministic data obtained for each simulation. The main contribution of the work is: Finding impact of probable realistic ZIP load modeling on balanced radial distribution load flow. Finding impact of probable realistic ZIP load modeling on unbalanced radial distribution load flow. Compare the voltage profile and losses with probable realistic ZIP load modeling for balanced and unbalanced radial distribution load flow.

  13. Medium-term load forecasting and wholesale transaction profitability

    International Nuclear Information System (INIS)

    Selker, F.K.; Wroblewski, W.R.

    1996-01-01

    The volume of wholesale transactions quoted at firm prices is increasing. The cost, and thus profitability, of serving these contracts strongly depends upon native load during the time of delivery. However, transactions extend beyond load forecasts based on weather information, and long-term resource planning forecasts of load peaks and energy provide inadequate detail. To address this need, Decision Focus Inc. (DFI) and Commonwealth Edison (ComEd) developed a probabilistic, medium-term load forecasting capability. In this paper the authors use a hypothetical utility to explore the impact of uncertain medium-term loads on transaction profitability

  14. Strong Ideal Convergence in Probabilistic Metric Spaces

    Indian Academy of Sciences (India)

    In the present paper we introduce the concepts of strongly ideal convergent sequence and strong ideal Cauchy sequence in a probabilistic metric (PM) space endowed with the strong topology, and establish some basic facts. Next, we define the strong ideal limit points and the strong ideal cluster points of a sequence in this ...

  15. Strong Statistical Convergence in Probabilistic Metric Spaces

    OpenAIRE

    Şençimen, Celaleddin; Pehlivan, Serpil

    2008-01-01

    In this article, we introduce the concepts of strongly statistically convergent sequence and strong statistically Cauchy sequence in a probabilistic metric (PM) space endowed with the strong topology, and establish some basic facts. Next, we define the strong statistical limit points and the strong statistical cluster points of a sequence in this space and investigate the relations between these concepts.

  16. Remnants of strong tidal interactions

    International Nuclear Information System (INIS)

    Mcglynn, T.A.

    1990-01-01

    This paper examines the properties of stellar systems that have recently undergone a strong tidal shock, i.e., a shock which removes a significant fraction of the particles in the system, and where the shocked system has a much smaller mass than the producer of the tidal field. N-body calculations of King models shocked in a variety of ways are performed, and the consequences of the shocks are investigated. The results confirm the prediction of Jaffe for shocked systems. Several models are also run where the tidal forces on the system are constant, simulating a circular orbit around a primary, and the development of tidal radii under these static conditions appears to be a mild process which does not dramatically affect material that is not stripped. The tidal radii are about twice as large as classical formulas would predict. Remnant density profiles are compared with a sample of elliptical galaxies, and the implications of the results for the development of stellar populations and galaxies are considered. 38 refs

  17. Strongly correlated perovskite fuel cells

    Science.gov (United States)

    Zhou, You; Guan, Xiaofei; Zhou, Hua; Ramadoss, Koushik; Adam, Suhare; Liu, Huajun; Lee, Sungsik; Shi, Jian; Tsuchiya, Masaru; Fong, Dillon D.; Ramanathan, Shriram

    2016-06-01

    Fuel cells convert chemical energy directly into electrical energy with high efficiencies and environmental benefits, as compared with traditional heat engines. Yttria-stabilized zirconia is perhaps the material with the most potential as an electrolyte in solid oxide fuel cells (SOFCs), owing to its stability and near-unity ionic transference number. Although there exist materials with superior ionic conductivity, they are often limited by their ability to suppress electronic leakage when exposed to the reducing environment at the fuel interface. Such electronic leakage reduces fuel cell power output and the associated chemo-mechanical stresses can also lead to catastrophic fracture of electrolyte membranes. Here we depart from traditional electrolyte design that relies on cation substitution to sustain ionic conduction. Instead, we use a perovskite nickelate as an electrolyte with high initial ionic and electronic conductivity. Since many such oxides are also correlated electron systems, we can suppress the electronic conduction through a filling-controlled Mott transition induced by spontaneous hydrogen incorporation. Using such a nickelate as the electrolyte in free-standing membrane geometry, we demonstrate a low-temperature micro-fabricated SOFC with high performance. The ionic conductivity of the nickelate perovskite is comparable to the best-performing solid electrolytes in the same temperature range, with a very low activation energy. The results present a design strategy for high-performance materials exhibiting emergent properties arising from strong electron correlations.

  18. Strong seismic ground motion propagation

    International Nuclear Information System (INIS)

    Seale, S.; Archuleta, R.; Pecker, A.; Bouchon, M.; Mohammadioun, G.; Murphy, A.; Mohammadioun, B.

    1988-10-01

    At the McGee Creek, California, site, 3-component strong-motion accelerometers are located at depths of 166 m, 35 m and 0 m. The surface material is glacial moraine, to a depth of 30.5 m, overlying homfels. Accelerations were recorded from two California earthquakes: Round Valley, M L 5.8, November 23, 1984, 18:08 UTC and Chalfant Valley, M L 6.4, July 21, 1986, 14:42 UTC. By separating out the SH components of acceleration, we were able to determine the orientations of the downhole instruments. By separating out the SV component of acceleration, we were able to determine the approximate angle of incidence of the signal at 166 m. A constant phase velocity Haskell-Thomson model was applied to generate synthetic SH seismograms at the surface using the accelerations recorded at 166 m. In the frequency band 0.0 - 10.0 Hz, we compared the filtered synthetic records to the filtered surface data. The onset of the SH pulse is clearly seen, as are the reflections from the interface at 30.5 m. The synthetic record closely matches the data in amplitude and phase. The fit between the synthetic accelerogram and the data shows that the seismic amplification at the surface is a result of the contrast of the impedances (shear stiffnesses) of the near surface materials

  19. Dynamics of levitated nanospheres: towards the strong coupling regime

    International Nuclear Information System (INIS)

    Monteiro, T S; Millen, J; Pender, G A T; Barker, P F; Marquardt, Florian; Chang, D

    2013-01-01

    The use of levitated nanospheres represents a new paradigm for the optomechanical cooling of a small mechanical oscillator, with the prospect of realizing quantum oscillators with unprecedentedly high quality factors. We investigate the dynamics of this system, especially in the so-called self-trapping regime, where one or more optical fields simultaneously trap and cool the mechanical oscillator. The determining characteristic of this regime is that both the mechanical frequency ω M and single-photon optomechanical coupling strength parameters g are a function of the optical field intensities, in contrast to usual set-ups where ω M and g are constant for the given system. We also measure the characteristic transverse and axial trapping frequencies of different sized silica nanospheres in a simple optical standing wave potential, for spheres of radii r = 20–500 nm, illustrating a protocol for loading single nanospheres into a standing wave optical trap that would be formed by an optical cavity. We use these data to confirm the dependence of the effective optomechanical coupling strength on sphere radius for levitated nanospheres in an optical cavity and discuss the prospects for reaching regimes of strong light–matter coupling. Theoretical semiclassical and quantum displacement noise spectra show that for larger nanospheres with r ∼> 100 nm a range of interesting and novel dynamical regimes can be accessed. These include simultaneous hybridization of the two optical modes with the mechanical modes and parameter regimes where the system is bistable. We show that here, in contrast to typical single-optical mode optomechanical systems, bistabilities are independent of intracavity intensity and can occur for very weak laser driving amplitudes. (paper)

  20. Optimization of Nanowire-Resistance Load Logic Inverter.

    Science.gov (United States)

    Hashim, Yasir; Sidek, Othman

    2015-09-01

    This study is the first to demonstrate characteristics optimization of nanowire resistance load inverter. Noise margins and inflection voltage of transfer characteristics are used as limiting factors in this optimization. Results indicate that optimization depends on resistance value. Increasing of load resistor tends to increasing in noise margins until saturation point, increasing load resistor after this point will not improve noise margins significantly.

  1. Processing Capacity under Perceptual and Cognitive Load: A Closer Look at Load Theory

    Science.gov (United States)

    Fitousi, Daniel; Wenger, Michael J.

    2011-01-01

    Variations in perceptual and cognitive demands (load) play a major role in determining the efficiency of selective attention. According to load theory (Lavie, Hirst, Fockert, & Viding, 2004) these factors (a) improve or hamper selectivity by altering the way resources (e.g., processing capacity) are allocated, and (b) tap resources rather than…

  2. John Strong 1941-2006

    CERN Multimedia

    2006-01-01

    John started his career and obtained his PhD in a group from Westfield College, initially working on experiments at Rutherford Appleton Laboratory (RAL). From the early 1970s onwards, however, his research was focused on experiments in CERN, with several particularly notable contributions. The Omega spectrometer adopted a system John had originally developed for experiments at RAL using vidicon Cameras (a type of television camera) to record the sparks in the spark chambers. This highly automated system allowed Omega to be used in a similar way to bubble chambers.  He contributed to the success of NA1 and NA7, where he became heavily involved in the electronic trigger systems. In these experiments the Westfield group joined forces with Italian colleagues to measure the form factors of the pion and the kaon, and the lifetime of some of the newly discovered charm particles. Such has been the lasting impact of these measurements that the paper on the pion form-factor had been cited 323 times up to the time of J...

  3. Concentrated loads on concrete

    DEFF Research Database (Denmark)

    Lorenzen, Karen Grøndahl; Nielsen, Mogens Peter

    1997-01-01

    This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas are devel......This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas...

  4. Critical Axial Load

    Directory of Open Access Journals (Sweden)

    Walt Wells

    2008-01-01

    Full Text Available Our objective in this paper is to solve a second order differential equation for a long, simply supported column member subjected to a lateral axial load using Heun's numerical method. We will use the solution to find the critical load at which the column member will fail due to buckling. We will calculate this load using Euler's derived analytical approach for an exact solution, as well as Euler's Numerical Method. We will then compare the three calculated values to see how much they deviate from one another. During the critical load calculation, it will be necessary to calculate the moment of inertia for the column member.

  5. Load regulating expansion fixture

    International Nuclear Information System (INIS)

    Wagner, L.M.; Strum, M.J.

    1998-01-01

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils is disclosed. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located there between. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components. 1 fig

  6. Laterally loaded masonry

    DEFF Research Database (Denmark)

    Raun Gottfredsen, F.

    In this thesis results from experiments on mortar joints and masonry as well as methods of calculation of strength and deformation of laterally loaded masonry are presented. The strength and deformation capacity of mortar joints have been determined from experiments involving a constant compressive...... stress and increasing shear. The results show a transition to pure friction as the cohesion is gradually destroyed. An interface model of a mortar joint that can take into account this aspect has been developed. Laterally loaded masonry panels have also been tested and it is found to be characteristic...... that laterally loaded masonry exhibits a non-linear load-displacement behaviour with some ductility....

  7. Electrical load modeling

    Energy Technology Data Exchange (ETDEWEB)

    Valgas, Helio Moreira; Pinto, Roberto del Giudice R.; Franca, Carlos [Companhia Energetica de Minas Gerais (CEMIG), Belo Horizonte, MG (Brazil); Lambert-Torres, Germano; Silva, Alexandre P. Alves da; Pires, Robson Celso; Costa, Junior, Roberto Affonso [Escola Federal de Engenharia de Itajuba, MG (Brazil)

    1994-12-31

    Accurate dynamic load models allow more precise calculations of power system controls and stability limits, which are critical mainly in the operation planning of power systems. This paper describes the development of a computer program (software) for static and dynamic load model studies using the measurement approach for the CEMIG system. Two dynamic load model structures are developed and tested. A procedure for applying a set of measured data from an on-line transient recording system to develop load models is described. (author) 6 refs., 17 figs.

  8. Strongly interacting photons and atoms

    International Nuclear Information System (INIS)

    Alge, W.

    1999-05-01

    This thesis contains the main results of the research topics I have pursued during the my PhD studies at the University of Innsbruck and partly in collaboration with the Institut d' Optique in Orsay, France. It is divided into three parts. The first and largest part discusses the possibility of using strong standing waves as a tool to cool and trap neutral atoms in optical cavities. This is very important in the field of nonlinear optics where several successful experiments with cold atoms in cavities have been performed recently. A discussion of the optical parametric oscillator in a regime where the nonlinearity dominates the evolution is the topic of the second part. We investigated mainly the statistical properties of the cavity output of the three interactive cavity modes. Very recently a system has been proposed which promises fantastic properties. It should exhibit a giant Kerr nonlinearity with negligible absorption thus leading to a photonic turnstile device based on cold atoms in cavity. We have shown that this model suffers from overly simplistic assumptions and developed several more comprehensive approaches to study the behavior of this system. Apart from the division into three parts of different contents the thesis is divided into publications, supplements and invisible stuff. The intention of the supplements is to reach researchers which work in related areas and provide them with more detailed information about the concepts and the numerical tools we used. It is written especially for diploma and PhD students to give them a chance to use the third part of our work which is actually the largest one. They consist of a large number of computer programs we wrote to investigate the behavior of the systems in parameter regions where no hope exists to solve the equations analytically. (author)

  9. Topics in strong Langmuir turbulence

    International Nuclear Information System (INIS)

    Skoric, M.M.

    1981-01-01

    This thesis discusses certain aspects of the turbulence of a fully ionised non-isothermal plasma dominated by the Langmuir mode. Some of the basic properties of strongly turbulent plasmas are reviewed. In particular, interest is focused on the state of Langmuir turbulence, that is the turbulence of a simple externally unmagnetized plasma. The problem of the existence and dynamics of Langmuir collapse is discussed, often met as a non-linear stage of the modulational instability in the framework of the Zakharov equations (i.e. simple time-averaged dynamical equations). Possible macroscopic consequences of such dynamical turbulent models are investigated. In order to study highly non-linear collapse dynamics in its advanced stage, a set of generalized Zakharov equations are derived. Going beyond the original approximation, the author includes the effects of higher electron non-linearities and a breakdown of slow-timescale quasi-neutrality. He investigates how these corrections may influence the collapse stabilisation. Recently, it has been realised that the modulational instability in a Langmuir plasma will be accompanied by the collisionless-generation of a slow-timescale magnetic field. Accordingly, a novel physical situation has emerged which is investigated in detail. The stability of monochromatic Langmuir waves in a self-magnetized Langmuir plasma, is discussed, and the existence of a novel magneto-modulational instability shown. The wave collapse dynamics is investigated and a physical interpretation of the basic results is given. A problem of the transient analysis of an interaction of time-dependent electromagnetic pulses with linear cold plasma media is investigated. (Auth.)

  10. Promoting Strong Written Communication Skills

    Science.gov (United States)

    Narayanan, M.

    2015-12-01

    The reason that an improvement in the quality of technical writing is still needed in the classroom is due to the fact that universities are facing challenging problems not only on the technological front but also on the socio-economic front. The universities are actively responding to the changes that are taking place in the global consumer marketplace. Obviously, there are numerous benefits of promoting strong written communication skills. They can be summarized into the following six categories. First, and perhaps the most important: The University achieves learner satisfaction. The learner has documented verbally, that the necessary knowledge has been successfully acquired. This results in learner loyalty that in turn will attract more qualified learners.Second, quality communication lowers the cost per pupil, consequently resulting in increased productivity backed by a stronger economic structure and forecast. Third, quality communications help to improve the cash flow and cash reserves of the university. Fourth, having high quality communication enables the university to justify the need for high costs of tuition and fees. Fifth, better quality in written communication skills result in attracting top-quality learners. This will lead to happier and satisfied learners, not to mention greater prosperity for the university as a whole. Sixth, quality written communication skills result in reduced complaints, thus meaning fewer hours spent on answering or correcting the situation. The University faculty and staff are thus able to devote more time on scholarly activities, meaningful research and productive community service. References Boyer, Ernest L. (1990). Scholarship reconsidered: Priorities of the Professorate.Princeton, NJ: Carnegie Foundation for the Advancement of Teaching. Hawkins, P., & Winter, J. (1997). Mastering change: Learning the lessons of the enterprise.London: Department for Education and Employment. Buzzel, Robert D., and Bradley T. Gale. (1987

  11. An Adaptive, Multi-Rate Linear Quadratic Regulator for a Shipboard MVDC Distribution System with Constant Power Loads

    Science.gov (United States)

    2017-09-01

    investigation into the factors which most strongly influence ROA size would be instructive. The genetic algorithm could be modified to assess ROA size and an...DISTRIBUTION SYSTEM WITH CONSTANT POWER LOADS 5. FUNDING NUMBERS REL95 REK4K 6. AUTHOR(S) Adam J. Mills 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND

  12. The Statistical Properties of Host Load

    Directory of Open Access Journals (Sweden)

    Peter A. Dinda

    1999-01-01

    Full Text Available Understanding how host load changes over time is instrumental in predicting the execution time of tasks or jobs, such as in dynamic load balancing and distributed soft real‐time systems. To improve this understanding, we collected week‐long, 1 Hz resolution traces of the Digital Unix 5 second exponential load average on over 35 different machines including production and research cluster machines, compute servers, and desktop workstations. Separate sets of traces were collected at two different times of the year. The traces capture all of the dynamic load information available to user‐level programs on these machines. We present a detailed statistical analysis of these traces here, including summary statistics, distributions, and time series analysis results. Two significant new results are that load is self‐similar and that it displays epochal behavior. All of the traces exhibit a high degree of self‐similarity with Hurst parameters ranging from 0.73 to 0.99, strongly biased toward the top of that range. The traces also display epochal behavior in that the local frequency content of the load signal remains quite stable for long periods of time (150–450 s mean and changes abruptly at epoch boundaries. Despite these complex behaviors, we have found that relatively simple linear models are sufficient for short‐range host load prediction.

  13. Russia needs a strong counterpart

    International Nuclear Information System (INIS)

    Slovak, K.; Marcan, P.

    2008-01-01

    In this paper an interview with the head of OMV, Wolfgang Ruttenstorfer is published. There is extract from this interview: Q: There have been attempts to take over MOL for a quite long time. Do you think you can still succeed? Since the beginning we kept saying that this would not happen from one day to another. But it may take two to three years. But we are positive that it is justified. Q: Resistance from MOL and the Hungarian government is strong. We have tried to persuade the Hungarian government. We offered them a split company management. A part of the management would be in Budapest. We would locate the management of the largest division - the refinery, there. And of course only the best could be part of the management. We would not nominate people according to their nationality, it would not matter whether the person was Austrian, Hungarian or Slovak. We want a Central European company, not Hungarian, Romanian or Slovak company. Q: Would the transaction still be attractive if, because of pressure exercised by Brussels, you had to sell Slovnaft or your refinery in Szazhalobatta? We do not intend to sell any refineries. Q: Rumours are spreading that the Commission may ask you to sell a refinery? We do not want to speculate. Let us wait and see what happens. We do not want to sell refineries. Q: It is said that OMV is coordinating or at least consulting its attempts to acquire MOL with Gazprom. There are many rumours in Central Europe. But I can tell you this is not true. We are interested in this merger because we feel the increasing pressure exercised by Kazakhstan and Russia. We, of course, have a good relationship with Gazprom which we have had enjoyed for over forty years. As indeed Slovakia has. Q: A few weeks ago Austrian daily Wirtschaftsblatt published an article about Gazprom's interest in OMV shares. That is gossip that is more than ten years' old. Similarly to the rumours that Gazprom is a shareholder of MOL. There are no negotiations with Gazprom

  14. Investigation of strong motion processing procedures

    International Nuclear Information System (INIS)

    Rinaldi, D.; Goula, X.; Menu, J.M.

    1988-03-01

    The work which is described here presents preliminary results of an on-going research relating to the accurate recording and quality processing of earthquake strong ground motions. The work is the product of a tripartite co-operation between three European Centres (ENEA, PAS-ISP Laboratorio Ingengneria dei Siti, Rome/CEA, IPSN, Fontenay-aux-Roses, ICST, Department of Civil Engineering, London), which have carried out independently similar research in the recent past. Other European Institutes joined the three mentioned organizations for discussions during a Workshop (June 1985) held in Casaccia (ENEA Research Centre of Rome). The aim of the research is a thorough analysis of various factors affecting the recovery of true ground accelerations recorded with analogue instruments. The separate and cumulative effects of the type of recording accelerometer, the digitization equipment and the correction routines have been analysed. Global comparisons have been achieved to obtain a general insight into various standard processing procedures

  15. Loading ion exchange resins with uranium for HTGR fuel kernels

    International Nuclear Information System (INIS)

    Notz, K.J.; Greene, C.W.

    1976-12-01

    Uranium-loaded ion exchange beads provide an excellent starting material in the production of uranium carbide microspheres for nuclear fuel applications. Both strong-acid (sulfonate) and weak-acid (carboxylate) resins can be fully loaded with uranium from a uranyl nitrate solution utilizing either a batch method or a continuous column technique

  16. Load Balancing in Hypergraphs

    Science.gov (United States)

    Delgosha, Payam; Anantharam, Venkat

    2018-03-01

    Consider a simple locally finite hypergraph on a countable vertex set, where each edge represents one unit of load which should be distributed among the vertices defining the edge. An allocation of load is called balanced if load cannot be moved from a vertex to another that is carrying less load. We analyze the properties of balanced allocations of load. We extend the concept of balancedness from finite hypergraphs to their local weak limits in the sense of Benjamini and Schramm (Electron J Probab 6(23):13, 2001) and Aldous and Steele (in: Probability on discrete structures. Springer, Berlin, pp 1-72, 2004). To do this, we define a notion of unimodularity for hypergraphs which could be considered an extension of unimodularity in graphs. We give a variational formula for the balanced load distribution and, in particular, we characterize it in the special case of unimodular hypergraph Galton-Watson processes. Moreover, we prove the convergence of the maximum load under some conditions. Our work is an extension to hypergraphs of Anantharam and Salez (Ann Appl Probab 26(1):305-327, 2016), which considered load balancing in graphs, and is aimed at more comprehensively resolving conjectures of Hajek (IEEE Trans Inf Theory 36(6):1398-1414, 1990).

  17. Load Induced Blindness

    Science.gov (United States)

    Macdonald, James S. P.; Lavie, Nilli

    2008-01-01

    Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied on indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005, for a review). Here we varied the level of…

  18. Load event: Aircraft crash

    International Nuclear Information System (INIS)

    Fritsch, H.

    1985-01-01

    The bibliography includes 48 quotations, up to the year 1983, on the following issues: Experiments and computational methods. Design load for the dimensioning of reinforced concrete buildings and components with respect to the dynamic load in the event of an aircraft crash. (orig./HP) [de

  19. Maximum allowable load on wheeled mobile manipulators

    International Nuclear Information System (INIS)

    Habibnejad Korayem, M.; Ghariblu, H.

    2003-01-01

    This paper develops a computational technique for finding the maximum allowable load of mobile manipulator during a given trajectory. The maximum allowable loads which can be achieved by a mobile manipulator during a given trajectory are limited by the number of factors; probably the dynamic properties of mobile base and mounted manipulator, their actuator limitations and additional constraints applied to resolving the redundancy are the most important factors. To resolve extra D.O.F introduced by the base mobility, additional constraint functions are proposed directly in the task space of mobile manipulator. Finally, in two numerical examples involving a two-link planar manipulator mounted on a differentially driven mobile base, application of the method to determining maximum allowable load is verified. The simulation results demonstrates the maximum allowable load on a desired trajectory has not a unique value and directly depends on the additional constraint functions which applies to resolve the motion redundancy

  20. Critical traffic loading for the design of prestressed concrete bridge

    International Nuclear Information System (INIS)

    Hassan, M.I.U.

    2009-01-01

    A study has been carried out to determine critical traffic loadings for the design of bridge superstructures. The prestressed concrete girder bridge already constructed in Lahore is selected for the analysis as an example. Standard traffic loadings according to AASHTO (American Association of State Highway and Transportation Officials) and Pakistan Highway Standards are used for this purpose. These include (1) HL-93 Truck, (2) Lane and (3) Tandem Loadings in addition to (4) Military tank loading, (5) Class-A, (6) Class-B and (7) Class-AA loading, (8) NLC (National Logistic Cell) and (9) Volvo truck loadings. Bridge superstructure including transom beam is analyzed Using ASD and LRFD (Load and Resistance Factor Design) provisions of AASHTO specifications. For the analysis, two longer and shorter spans are selected. This includes the analysis of bridge deck; interior and exterior girder; a typical transom beam and a pier. Dead and live loading determination is carried out using both computer aided and manual calculations. Evaluation of traffic loadings is done for all the bridge components to find out the critical loading. HL-93 loading comes out to be the most critical loading and where this loading is not critical in case of bridge decks; a factor of 1.15 is introduced to make it equivalent with HL-93 -Ioading. SAP-2000 (Structural Engineering Services of Pakistan) and MS-Excel is employed for analysis of bridge superstructure subjected to this loading. Internal forces are obtained for the structural elements of the bridge for all traffic loadings mentioned. It is concluded that HL-93 loading can be used for the design of prestressed concrete girder bridge. Bridge design authorities like NHA (National Highway Authority) and different cities development authorities are using different standard traffic loadings. A number of suggestions are made from the results of the research work related to traffic loadings and method of design. These recommendations may be

  1. Phosphorous loads evaluation from soil

    International Nuclear Information System (INIS)

    Mezzanotte, V.

    1996-01-01

    With reference to the well known difficulty of quantifying non point phosphorous loads, as well as to their growing relative importance where point source leads decrease, a literature review has been carried out concerning soil export coefficients. On such basis, the values which seem to be the most appropriate for Italy have been estimated for different land use categories. The main mechanisms determining non point phosphorous load generation and the factors affecting their importance are also described. In the end, criteria for estimating the importance of non point sources in a basin are suggested to be used for deciding whether a traditional, parametric assessment (inevitably involving a certain error) can be acceptable or experimental measures are needed

  2. The analysis of loading losses from tank trucks

    Directory of Open Access Journals (Sweden)

    Jovanović Ana P.

    2006-01-01

    Full Text Available The quantity of loading losses, which are the primary source of evaporative emissions from tank cars and trucks was analyzed in this paper. Loading losses occur as organic vapors in "empty" cargo tanks are displaced to the atmosphere by the liquid being loaded into the tanks. Emissions from loading petroleum liquid were estimated using three methods: the API (American Petroleum Institute method, the VDI (Verein Deutscher Ingenieure -Association of German Engineers method and the Yugoslav Standard JUS B.HO.531 method. The mass of evaporative losses from loading operations is a function of the following parameters: the method of loading the cargo, the physical and chemical characteristics of the cargo and the ambient temperature during loading. Evaporation losses from the loading of motor gasoline (MB-95, BMB-95, MB-98 and MB-86 and diesel fuels (D-2, Euro D-2 were calculated. Losses on a monthly and annual basis were presented for an assumed amount of loaded cargo. It was estimated that the highest loading losses occur in the summer period because of high ambient daily temperatures and in the period of higher transporting levels. It should be pointed out that the loading losses of diesel fuel calculated using an empirical coefficient according to JUS B.HO.531 are significantly higher in comparison with the loading losses calculated using emission factors from the EPA and the VDI method. The gasoline loading losses calculated using emission factors derived from the three methods are similar.

  3. Macrophyte Community Response to Nitrogen Loading and ...

    Science.gov (United States)

    Empirical determination of nutrient loading thresholds that negatively impact seagrass communities have been elusive due to the multitude of factors involved. Using a mesocosm system that simulated Pacific Northwest estuaries, we evaluated macrophyte metrics across gradients of NO3 loading (0, 1.5, 3 and 6x ambient) and temperature (10 and 20 °C). Macroalgal growth, biomass, and C:N responded positively to increased NO3 load and floating algal mats developed at 20 ºC. Zostera japonica metrics, including C:N, responded more to temperature than to NO3 loading. Z. marina biomass exhibited a negative temperature effect and in some cases a negative NO3 effect, while growth rate increased with temperature. Shoot survival decreased at 20 ºC but was not influenced by NO3 loading. Wasting disease index exhibited a significant temperature by NO3 interaction consistent with increased disease susceptibility. Community shifts observed were consistent with the nutrient loading hypothesis at 20 ºC, but there was no evidence of other eutrophication symptoms due to the short residence time. The Nutrient Pollution Index tracked the NO3 gradient at 10 ºC but exhibited no response at 20 ºC. We suggest that systems characterized by cool temperatures, high NO3 loads, and short residence time may be resilient to many symptoms of eutrophication. Estuarine systems characterized by cool temperatures, high nutrient loads and rapid flushing may be resilient to some symptoms

  4. Composite Materials and Meta Materials for a New Approach to ITER ICRH Loads

    International Nuclear Information System (INIS)

    Bottollier-Curtet, H.; Argouarch, A.; Vulliez, K.; Becoulet, A.; Litaudon, X.; Magne, R.; Champeaux, S.; Gouard, Ph.; Primout, M.; Le Gallou, J.-H.

    2009-01-01

    Preliminary laboratory testing of ICRH antennas is a very useful step before their commissioning. Traditionally, pure water, salt water or baking soda water loads are used. These 'water' loads are convenient but strongly limited in terms of performance testing. We have started two feasibility studies for advanced ICRH loads made of ferroelectric ceramics (passive loads) and meta materials (active loads). Preliminary results are very encouraging.

  5. Composite Materials and Meta Materials for a New Approach to ITER ICRH Loads

    Science.gov (United States)

    Bottollier-Curtet, H.; Argouarch, A.; Champeaux, S.; Gouard, Ph.; Le Gallou, J.-H.; Primout, M.; Vulliez, K.; Bécoulet, A.; Litaudon, X.; Magne, R.

    2009-11-01

    Preliminary laboratory testing of ICRH antennas is a very useful step before their commissioning. Traditionally, pure water, salt water or baking soda water loads are used. These "water" loads are convenient but strongly limited in terms of performance testing. We have started two feasibility studies for advanced ICRH loads made of ferroelectric ceramics (passive loads) and meta materials (active loads) [1]. Preliminary results are very encouraging.

  6. Strong Motion Seismograph Based On MEMS Accelerometer

    Science.gov (United States)

    Teng, Y.; Hu, X.

    2013-12-01

    application program layer mainly concludes: earthquake parameter module, local database managing module, data transmission module, remote monitoring, FTP service and so on. The application layer adopted multi-thread process. The whole strong motion seismograph was encapsulated in a small aluminum box, which size is 80mm×120mm×55mm. The inner battery can work continuesly more than 24 hours. The MEMS accelerograph uses modular design for its software part and hardware part. It has remote software update function and can meet the following needs: a) Auto picking up the earthquake event; saving the data on wave-event files and hours files; It may be used for monitoring strong earthquake, explosion, bridge and house health. b) Auto calculate the earthquake parameters, and transferring those parameters by 3G wireless broadband network. This kind of seismograph has characteristics of low cost, easy installation. They can be concentrated in the urban region or areas need to specially care. We can set up a ground motion parameters quick report sensor network while large earthquake break out. Then high-resolution-fine shake-map can be easily produced for the need of emergency rescue. c) By loading P-wave detection program modules, it can be used for earthquake early warning for large earthquakes; d) Can easily construct a high-density layout seismic monitoring network owning remote control and modern intelligent earthquake sensor.

  7. Load Balancing Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  8. Status of load management

    Energy Technology Data Exchange (ETDEWEB)

    Juchymenko, A

    1983-08-01

    A summary is presented of the status of load management, defined as any activity by an electric utility to affect the size and characteristics of its load. Load management is currently viewed by electric utilities as an important tool for marketing electricity in a competitive fuel situation. A major aim of the National Energy Program is to reduce Canada's dependence on oil by 1990 to 10% of the energy used by all markets. As a result, electricity may play a greater role in the supply of primary energy. Research in load management has been directed mostly towards the residential market, especially direct control of domestic hot water heaters and air conditioners. Studies conducted in Canada and the U.S. to determine user's receptiveness to direct control of loads and thermal energy storage systems indicate that these load management techniques are in most cases not acceptable to customers, who prefer voluntary reduction in demand. The potential exists in the industrial market to use load management to assist in electrifying many of the fossil fuel-fired processes at competitive energy prices. Some of the more important applications include an industrial heat pump to heat liquids to 120{degree}C, induction heating for melting and heat treating of metals, and mechanical vapor recompression equipment to produce proces steam. 21 refs., 2 figs., 2 tabs.

  9. Performance of a cognitive load inventory during simulated handoffs: Evidence for validity.

    Science.gov (United States)

    Young, John Q; Boscardin, Christy K; van Dijk, Savannah M; Abdullah, Ruqayyah; Irby, David M; Sewell, Justin L; Ten Cate, Olle; O'Sullivan, Patricia S

    2016-01-01

    Advancing patient safety during handoffs remains a public health priority. The application of cognitive load theory offers promise, but is currently limited by the inability to measure cognitive load types. To develop and collect validity evidence for a revised self-report inventory that measures cognitive load types during a handoff. Based on prior published work, input from experts in cognitive load theory and handoffs, and a think-aloud exercise with residents, a revised Cognitive Load Inventory for Handoffs was developed. The Cognitive Load Inventory for Handoffs has items for intrinsic, extraneous, and germane load. Students who were second- and sixth-year students recruited from a Dutch medical school participated in four simulated handoffs (two simple and two complex cases). At the end of each handoff, study participants completed the Cognitive Load Inventory for Handoffs, Paas' Cognitive Load Scale, and one global rating item for intrinsic load, extraneous load, and germane load, respectively. Factor and correlational analyses were performed to collect evidence for validity. Confirmatory factor analysis yielded a single factor that combined intrinsic and germane loads. The extraneous load items performed poorly and were removed from the model. The score from the combined intrinsic and germane load items associated, as predicted by cognitive load theory, with a commonly used measure of overall cognitive load (Pearson's r = 0.83, p load during handoffs may be measured via a self-report measure. Additional work is required to develop an adequate measure of extraneous load.

  10. Baryon bags in strong coupling QCD

    Science.gov (United States)

    Gattringer, Christof

    2018-04-01

    We discuss lattice QCD with one flavor of staggered fermions and show that in the path integral the baryon contributions can be fully separated from quark and diquark contributions. The baryonic degrees of freedom (d.o.f.) are independent of the gauge field, and the corresponding free fermion action describes the baryons through the joint propagation of three quarks. The nonbaryonic dynamics is described by quark and diquark terms that couple to the gauge field. When evaluating the quark and diquark contributions in the strong coupling limit, the partition function completely factorizes into baryon bags and a complementary domain. Baryon bags are regions in space-time where the dynamics is described by a single free fermion made out of three quarks propagating coherently as a baryon. Outside the baryon bags, the relevant d.o.f. are monomers and dimers for quarks and diquarks. The partition sum is a sum over all baryon bag configurations, and for each bag, a free fermion determinant appears as a weight factor.

  11. Diffusion Indexes With Sparse Loadings

    DEFF Research Database (Denmark)

    Kristensen, Johannes Tang

    2017-01-01

    The use of large-dimensional factor models in forecasting has received much attention in the literature with the consensus being that improvements on forecasts can be achieved when comparing with standard models. However, recent contributions in the literature have demonstrated that care needs...... to the problem by using the least absolute shrinkage and selection operator (LASSO) as a variable selection method to choose between the possible variables and thus obtain sparse loadings from which factors or diffusion indexes can be formed. This allows us to build a more parsimonious factor model...... in forecasting accuracy and thus find it to be an important alternative to PC. Supplementary materials for this article are available online....

  12. Auditory working memory load impairs visual ventral stream processing: toward a unified model of attentional load.

    Science.gov (United States)

    Klemen, Jane; Büchel, Christian; Bühler, Mira; Menz, Mareike M; Rose, Michael

    2010-03-01

    Attentional interference between tasks performed in parallel is known to have strong and often undesired effects. As yet, however, the mechanisms by which interference operates remain elusive. A better knowledge of these processes may facilitate our understanding of the effects of attention on human performance and the debilitating consequences that disruptions to attention can have. According to the load theory of cognitive control, processing of task-irrelevant stimuli is increased by attending in parallel to a relevant task with high cognitive demands. This is due to the relevant task engaging cognitive control resources that are, hence, unavailable to inhibit the processing of task-irrelevant stimuli. However, it has also been demonstrated that a variety of types of load (perceptual and emotional) can result in a reduction of the processing of task-irrelevant stimuli, suggesting a uniform effect of increased load irrespective of the type of load. In the present study, we concurrently presented a relevant auditory matching task [n-back working memory (WM)] of low or high cognitive load (1-back or 2-back WM) and task-irrelevant images at one of three object visibility levels (0%, 50%, or 100%). fMRI activation during the processing of the task-irrelevant visual stimuli was measured in the lateral occipital cortex and found to be reduced under high, compared to low, WM load. In combination with previous findings, this result is suggestive of a more generalized load theory, whereby cognitive load, as well as other types of load (e.g., perceptual), can result in a reduction of the processing of task-irrelevant stimuli, in line with a uniform effect of increased load irrespective of the type of load.

  13. Making operations on standard-library containers strongly exception safe

    DEFF Research Database (Denmark)

    Katajainen, Jyrki

    2007-01-01

    -library containers to provide the strong guarantee of exception safety, instead of the default guarantee, without violating the stringent performance requirements specified in the C++ standard. In particular, we show that every strongly exception-safe operation on dynamic arrays and ordered dictionaries is only...... a constant factor slower than the corresponding default-guarantee operation. In terms of the amount of space, the overhead introduced is linear in the number of elements stored....

  14. On a strong law of large numbers for monotone measures

    Czech Academy of Sciences Publication Activity Database

    Agahi, H.; Mohammadpour, A.; Mesiar, Radko; Ouyang, Y.

    2013-01-01

    Roč. 83, č. 4 (2013), s. 1213-1218 ISSN 0167-7152 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : capacity * Choquet integral * strong law of large numbers Subject RIV: BA - General Mathematics Impact factor: 0.531, year: 2013 http://library.utia.cas.cz/separaty/2013/E/mesiar-on a strong law of large numbers for monotone measures.pdf

  15. Lumbriculus variegatus loading study

    Data.gov (United States)

    U.S. Environmental Protection Agency — Results from sediment bioaccumulation tests with Lumbriculus variegatus with evaluating the effects of organism loading density. This dataset is associated with the...

  16. LOADING SIMULATION PROGRAM C

    Science.gov (United States)

    LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for simulating hydrology, sediment, and general water quality

  17. LOADING SIMULATION PROGRAM C

    Data.gov (United States)

    U.S. Environmental Protection Agency — LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for...

  18. Cognitive load theory

    NARCIS (Netherlands)

    Kirschner, Paul A.; Kirschner, Femke; Paas, Fred

    2010-01-01

    Kirschner, P. A., Kirschner, F. C., & Paas, F. (2009). Cognitive load theory. In E. M. Anderman & L. H. Anderman (Eds.). Psychology of classroom learning: An encyclopedia, Volume 1, a-j (pp. 205-209). Detroit, MI: Macmillan Reference.

  19. Static Loads Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides the capability to perform large-scale structural loads testing on spacecraft and other structures. Results from these tests can be used to verify...

  20. Load proportional safety brake

    Science.gov (United States)

    Cacciola, M. J.

    1979-01-01

    This brake is a self-energizing mechanical friction brake and is intended for use in a rotary drive system. It incorporates a torque sensor which cuts power to the power unit on any overload condition. The brake is capable of driving against an opposing load or driving, paying-out, an aiding load in either direction of rotation. The brake also acts as a no-back device when torque is applied to the output shaft. The advantages of using this type of device are: (1) low frictional drag when driving; (2) smooth paying-out of an aiding load with no runaway danger; (3) energy absorption proportional to load; (4) no-back activates within a few degrees of output shaft rotation and resets automatically; and (5) built-in overload protection.

  1. Plug Load Data

    Data.gov (United States)

    National Aeronautics and Space Administration — We provide MATLAB binary files (.mat) and comma separated values files of data collected from a pilot study of a plug load management system that allows for the...

  2. Probabilistic representation of duration of load effects in timber structures

    DEFF Research Database (Denmark)

    Svensson, Staffan

    2011-01-01

    Reliability analysis of structures for the purpose of code calibration or reliability verification of specific structures requires that the relevant failure modes are represented and analyzed. For structural timber, sustaining a life load, two failure cases for each failure mode have......-based design of timber structures in terms of a modification factor View the MathML source which is multiplied on the short-term resistance of the timber material. The scenario of a beam subject to office space life loads is analyzed and the modification factor View the MathML source is calibrated by using...... to be considered. These two cases are maximum load level exceeding load-carrying capacity and damage accumulation (caused by the load and its duration) leading to failure. The effect of both load intensity and load duration on the capacity of timber has been an area of large interest over the last decades...

  3. Is It Possible to Predict Strong Earthquakes?

    Science.gov (United States)

    Polyakov, Y. S.; Ryabinin, G. V.; Solovyeva, A. B.; Timashev, S. F.

    2015-07-01

    The possibility of earthquake prediction is one of the key open questions in modern geophysics. We propose an approach based on the analysis of common short-term candidate precursors (2 weeks to 3 months prior to strong earthquake) with the subsequent processing of brain activity signals generated in specific types of rats (kept in laboratory settings) who reportedly sense an impending earthquake a few days prior to the event. We illustrate the identification of short-term precursors using the groundwater sodium-ion concentration data in the time frame from 2010 to 2014 (a major earthquake occurred on 28 February 2013) recorded at two different sites in the southeastern part of the Kamchatka Peninsula, Russia. The candidate precursors are observed as synchronized peaks in the nonstationarity factors, introduced within the flicker-noise spectroscopy framework for signal processing, for the high-frequency component of both time series. These peaks correspond to the local reorganizations of the underlying geophysical system that are believed to precede strong earthquakes. The rodent brain activity signals are selected as potential "immediate" (up to 2 weeks) deterministic precursors because of the recent scientific reports confirming that rodents sense imminent earthquakes and the population-genetic model of K irshvink (Soc Am 90, 312-323, 2000) showing how a reliable genetic seismic escape response system may have developed over the period of several hundred million years in certain animals. The use of brain activity signals, such as electroencephalograms, in contrast to conventional abnormal animal behavior observations, enables one to apply the standard "input-sensor-response" approach to determine what input signals trigger specific seismic escape brain activity responses.

  4. Enhanced sensitivity fibre Bragg grating (FBG) load sensor

    International Nuclear Information System (INIS)

    Correia, Ricardo; Chehura, Edmon; Li, Jin; James, Stephen W; Tatam, Ralph P

    2010-01-01

    The characterization of a load sensor based on the transverse loading of a subsection of a fibre Bragg grating (FBG) embedded within a cube of epoxy resin is presented. When the epoxy resin cube is loaded transverse to the axis of the fibre, its deformation transduces the load to a strain along the axis of the optical fibre, which changes the period of the embedded section of the FBG. This creates a spectral dropout within the bandwidth of the FBG, with an absolute wavelength that is linearly dependent on the applied load. This technique enhances the sensitivity of the FBG to transverse loading by a factor of 15, to 2.9 × 10 −2 ± 0.01 nm N −1 , when compared to the direct transverse loading of a bare fibre, and also protects the fibre from mechanical damage at the loading point

  5. Critical loads and excess loads of cadmium, copper and lead for European forest soils

    NARCIS (Netherlands)

    Reinds, G.J.; Bril, J.; Vries, de W.; Groenenberg, J.E.; Breeuwsma, A.

    1995-01-01

    Recently, concern has arisen about the impact of the dispersion of heavy metals in Europe. Therefore, a study (ESQUAD) was initiated to assess critical loads and steady-state concentrations of cadmium, copper and lead for European forest soils. The calculation methods used strongly resemble those

  6. Load power device, system and method of load control and management employing load identification

    Science.gov (United States)

    Yang, Yi; Luebke, Charles John; Schoepf, Thomas J.

    2018-01-09

    A load power device includes a power input, at least one power output for at least one load, a plurality of sensors structured to sense voltage and current at the at least one power output, and a processor. The processor provides: (a) load identification based upon the sensed voltage and current, and (b) load control and management based upon the load identification.

  7. Perceptual load in different regions of the visual scene and its relevance for driving.

    Science.gov (United States)

    Marciano, Hadas; Yeshurun, Yaffa

    2015-06-01

    The aim of this study was to better understand the role played by perceptual load, at both central and peripheral regions of the visual scene, in driving safety. Attention is a crucial factor in driving safety, and previous laboratory studies suggest that perceptual load is an important factor determining the efficiency of attentional selectivity. Yet, the effects of perceptual load on driving were never studied systematically. Using a driving simulator, we orthogonally manipulated the load levels at the road (central load) and its sides (peripheral load), while occasionally introducing critical events at one of these regions. Perceptual load affected driving performance at both regions of the visual scene. Critically, the effect was different for central versus peripheral load: Whereas load levels on the road mainly affected driving speed, load levels on its sides mainly affected the ability to detect critical events initiating from the roadsides. Moreover, higher levels of peripheral load impaired performance but mainly with low levels of central load, replicating findings with simple letter stimuli. Perceptual load has a considerable effect on driving, but the nature of this effect depends on the region of the visual scene at which the load is introduced. Given the observed importance of perceptual load, authors of future studies of driving safety should take it into account. Specifically, these findings suggest that our understanding of factors that may be relevant for driving safety would benefit from studying these factors under different levels of load at different regions of the visual scene. © 2014, Human Factors and Ergonomics Society.

  8. APS high heat load monochromator

    International Nuclear Information System (INIS)

    Lee, W.K.; Mills, D.

    1993-02-01

    This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach

  9. Simplified analysis of laterally loaded pile groups

    Directory of Open Access Journals (Sweden)

    F.M. Abdrabbo

    2012-06-01

    Full Text Available The response of laterally loaded pile groups is a complicated soil–structure interaction problem. Although fairly reliable methods are developed to predicate the lateral behavior of single piles, the lateral response of pile groups has attracted less attention due to the required high cost and complication implication. This study presents a simplified method to analyze laterally loaded pile groups. The proposed method implements p-multiplier factors in combination with the horizontal modulus of subgrade reaction. Shadowing effects in closely spaced piles in a group were taken into consideration. It is proven that laterally loaded piles embedded in sand can be analyzed within the working load range assuming a linear relationship between lateral load and lateral displacement. The proposed method estimates the distribution of lateral loads among piles in a pile group and predicts the safe design lateral load of a pile group. The benefit of the proposed method is in its simplicity for the preliminary design stage with a little computational effort.

  10. Hood River Conservation Project load analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, T.K.

    1987-11-01

    As a part of the Hood River Conservation Project (HRCP), 314 homes were monitored to measure electrical energy use. The total electrical load, space heating load, water heating load (in about 200 homes), wood-stove heat output (in about 100 homes), and indoor temperature were monitored. Data were collected for one full year before and one full year after these homes were retrofit with conservation measures. Local weather information was also collected on a 15-min basis. This data base was used to evaluate the load savings attributable to HRCP. Two methods of weather normalization were used and showed close agreement. The weather-normalized diversified residential load savings on the Pacific Power and Light system and Hood River area peak days were >0.5 kW/household. The average spring, summer, and fall savings were much smaller, <0.1 kW/household. The load factor for the diversified residential load decreased following the conservation retrofit actions. 11 refs., 40 figs., 13 tabs.

  11. ELBE - Validation and improvement of load prognoses (project phase 1); ELBE - Validierung und Verbesserung von Lastprognosen (Projektphase 1)

    Energy Technology Data Exchange (ETDEWEB)

    Kronig, P.; Waelchli, U.; Zuercher, S. [BKW FMB Energie AG, Bern (Switzerland); Hoeckel, M. [Berner Fachhochschule, Biel (Switzerland)

    2009-10-15

    In the project 'Prognosekompetenz' we have identified and quantified by means of a comprehensive analysis of grid and climate data the factors which have a significant impact on the grid load. The study focused in the beginning on the regional data from a big electricity utility. In a second step, additional local data were also considered to better identify climatic and economic characteristics. We found a strong correlation between load, on the one hand, and outdoor temperature and economic activity, on the other hand. The influence of further factors is very limited. On this basis we developed two Matlab-based, easy-to-use tools for the prediction of the daily grid load profile in quarter-of-hour steps. One tool uses the method of the transfer function, where specific correlation factors account for the influential factors. The second tool based on the method of the artificial neuronal network, which had been tuned with data from several years to make sure that a high accuracy is obtained. We could show by self developed testing procedures that for both tools the precision in forecasting the daily load profile is very high. (authors)

  12. Study on Mechanical Properties of Barite Concrete under Impact Load

    Science.gov (United States)

    Chen, Z. F.; Cheng, K.; Wu, D.; Gan, Y. C.; Tao, Q. W.

    2018-03-01

    In order to research the mechanical properties of Barite concrete under impact load, a group of concrete compression tests was carried out under the impact load by using the drop test machine. A high-speed camera was used to record the failure process of the specimen during the impact process. The test results show that:with the increase of drop height, the loading rate, the peak load, the strain under peak load, the strain rate and the dynamic increase factor (DIF) all increase gradually. The ultimate tensile strain is close to each other, and the time of impact force decreases significantly, showing significant strain rate effect.

  13. Design Load Basis for Offshore Wind turbines

    DEFF Research Database (Denmark)

    Natarajan, Anand; Hansen, Morten Hartvig; Wang, Shaofeng

    2016-01-01

    DTU Wind Energy is not designing and manufacturing wind turbines and does therefore not need a Design Load Basis (DLB) that is accepted by a certification body. However, to assess the load consequences of innovative features and devices added to existing offshore turbine concepts or new offshore...... turbine concept developed in our research, it is useful to have a full DLB that follows the current design standard and is representative of a general DLB used by the industry. It will set a standard for the offshore wind turbine design load evaluations performed at DTU Wind Energy, which is aligned...... with the challenges faced by the industry and therefore ensures that our research continues to have a strong foundation in this interaction. Furthermore, the use of a full DLB that follows the current standard can improve and increase the feedback from the research at DTU Wind Energy to the international...

  14. Strong Bisimilarity of Simple Process Algebras

    DEFF Research Database (Denmark)

    Srba, Jirí

    2003-01-01

    We study bisimilarity and regularity problems of simple process algebras. In particular, we show PSPACE-hardness of the following problems: (i) strong bisimilarity of Basic Parallel Processes (BPP), (ii) strong bisimilarity of Basic Process Algebra (BPA), (iii) strong regularity of BPP, and (iv......) strong regularity of BPA. We also demonstrate NL-hardness of strong regularity problems for the normed subclasses of BPP and BPA. Bisimilarity problems of simple process algebras are introduced in a general framework of process rewrite systems, and a uniform description of the new techniques used...

  15. Application of strong phosphoric acid to radiochemistry

    International Nuclear Information System (INIS)

    Terada, Kikuo

    1977-01-01

    Not only inorganic and organic compounds but also natural substrances, such as accumulations in soil, are completely decomposed and distilled by heating with strong phosphoric acid for 30 to 50 minutes. As applications of strong phosphoric acid to radiochemistry, determination of uranium and boron by use of solubilization effect of this substance, titration of uranyl ion by use of sulfuric iron (II) contained in this substance, application to tracer experiment, and determination of radioactive ruthenium in environmental samples are reviewed. Strong phosphoric acid is also applied to activation analysis, for example, determination of N in pyrographite with iodate potassium-strong phosphoric acid method, separation of Os and Ru with sulfuric cerium (IV) - strong phosphoric acid method or potassium dechromate-strong phosphoric acid method, analysis of Se, As and Sb rocks and accumulations with ammonium bromide, sodium chloride and sodium bromide-strong phosphoric acid method. (Kanao, N.)

  16. Rating curve estimation of nutrient loads in Iowa rivers

    Science.gov (United States)

    Stenback, G.A.; Crumpton, W.G.; Schilling, K.E.; Helmers, M.J.

    2011-01-01

    Accurate estimation of nutrient loads in rivers and streams is critical for many applications including determination of sources of nutrient loads in watersheds, evaluating long-term trends in loads, and estimating loading to downstream waterbodies. Since in many cases nutrient concentrations are measured on a weekly or monthly frequency, there is a need to estimate concentration and loads during periods when no data is available. The objectives of this study were to: (i) document the performance of a multiple regression model to predict loads of nitrate and total phosphorus (TP) in Iowa rivers and streams; (ii) determine whether there is any systematic bias in the load prediction estimates for nitrate and TP; and (iii) evaluate streamflow and concentration factors that could affect the load prediction efficiency. A commonly cited rating curve regression is utilized to estimate riverine nitrate and TP loads for rivers in Iowa with watershed areas ranging from 17.4 to over 34,600km2. Forty-nine nitrate and 44 TP datasets each comprising 5-22years of approximately weekly to monthly concentrations were examined. Three nitrate data sets had sample collection frequencies averaging about three samples per week. The accuracy and precision of annual and long term riverine load prediction was assessed by direct comparison of rating curve load predictions with observed daily loads. Significant positive bias of annual and long term nitrate loads was detected. Long term rating curve nitrate load predictions exceeded observed loads by 25% or more at 33% of the 49 measurement sites. No bias was found for TP load prediction although 15% of the 44 cases either underestimated or overestimate observed long-term loads by more than 25%. The rating curve was found to poorly characterize nitrate and phosphorus variation in some rivers. ?? 2010 .

  17. Emission factors and chemical characterisation of fine particulate emissions from modern and old residential biomass heating systems determined for typical load cycles; Emissionsfaktoren und chemische Charakterisierung von Feinstaubemissionen moderner und alter Biomasse-Kleinfeuerungen ueber typische Tageslastverlaeufe

    Energy Technology Data Exchange (ETDEWEB)

    Kelz, Joachim [BIOENERGY 2020+ GmbH, Graz (Austria); Brunner, Thomas; Obernberger, Ingwald [BIOENERGY 2020+ GmbH, Graz (Austria); Technische Universitaet Graz, Institut fuer Prozess- und Partikeltechnik, Graz (Austria); BIOS BIOENERGIESYSTEME GmbH, Graz (Austria)

    2012-12-15

    It is already well known that there are significant differences regarding the emissions, especially particulate matter (PM) emissions, of old and modern as well as automatically and not automatically controlled biomass based residential heating systems. This concerns their magnitude as well as their chemical composition. In order to investigate emission factors for particulate emissions and the chemical compositions of the PM emissions over typical whole day operation cycles, a project on the determination and characterisation of PM emissions from the most relevant small-scale biomass combustion systems was performed at the BIOENERGY 2020+ GmbH, Graz, Austria, in cooperation with the Institute for Process and Particle Engineering, Graz University of Technology. The project was based on test stand measurements, during which relevant operation parameters (gaseous emissions, boiler load, flue gas temperature, combustion chamber temperature etc.) as well as PM emissions have been measured and PM samples have been taken and forwarded to chemical analyses. Firstly, typical whole day operation cycles for residential biomass combustion systems were specified for the test runs. Thereby automatically fed and automatically controlled boilers, manually fed and automatically controlled boilers as well as manually fed stoves were distinguished. The results show a clear correlation between the gaseous emissions (CO and OGC) and the PM{sub 1} emissions. It is indicated that modern biomass combustion systems emit significantly less gaseous and PM emissions than older technologies (up to a factor of 100). Moreover, automatically fed systems emit much less gaseous and PM emissions than manually fed batch-combustion systems. PM emissions from modern and automatically controlled systems mainly consist of alkaline metal salts, while organic aerosols and soot dominate the composition of aerosols from old and not automatically controlled systems. As an important result comprehensive data

  18. Demand for Neste's City products grows strongly

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Finland's oil, chemicals, and gas company, Neste Corporation, is well on the road to better financial performance after a very difficult year in 1992. Among the factors contributing to this optimism are Neste's pioneering low environmental impact traffic fuels. Neste Corporation's net sales in 1993 rose 9.9 % on 1992 figures to USD 11,011 million. Investments totalled USD 681 million. Profitability also improved during 1993, and the operating margin rose by 57 %, despite the recession affecting the Finnish economy and the instability of the international market. The operational loss for the year before extraordinary items, reserves, and taxes was USD 265 million, one-third less than in 1992. Neste's strategy has been to achieve a strong position in the Baltic Rim region by becoming the quality and cost leader in oil refining, and by expanding Neste's position in its key markets. A total of 3.3 million tonnes of petroleum products were exported from Finland in 1993. Neste's most important export markets were Sweden, Germany, Poland, the Baltic countries, and the St. Petersburg region. Some 20 % of exports went to customers outside Europe. In addition to Finland, Neste has concertedly developed its service station network in Poland and the Baltic countries

  19. Strong tracking adaptive Kalman filters for underwater vehicle dead reckoning

    Institute of Scientific and Technical Information of China (English)

    XIAO Kun; FANG Shao-ji; PANG Yong-jie

    2007-01-01

    To improve underwater vehicle dead reckoning, a developed strong tracking adaptive kalman filter is proposed. The filter is improved with an additional adaptive factor and an estimator of measurement noise covariance. Since the magnitude of fading factor is changed adaptively, the tracking ability of the filter is still enhanced in low velocity condition of underwater vehicles. The results of simulation tests prove the presented filter effective.

  20. Femoral loading mechanics in the Virginia opossum, Didelphis virginiana: torsion and mediolateral bending in mammalian locomotion.

    Science.gov (United States)

    Gosnell, W Casey; Butcher, Michael T; Maie, Takashi; Blob, Richard W

    2011-10-15

    Studies of limb bone loading in terrestrial mammals have typically found anteroposterior bending to be the primary loading regime, with torsion contributing minimally. However, previous studies have focused on large, cursorial eutherian species in which the limbs are held essentially upright. Recent in vivo strain data from the Virginia opossum (Didelphis virginiana), a marsupial that uses a crouched rather than an upright limb posture, have indicated that its femur experiences appreciable torsion during locomotion as well as strong mediolateral bending. The elevated femoral torsion and strong mediolateral bending observed in D. virginiana might result from external forces such as a medial inclination of the ground reaction force (GRF), internal forces deriving from a crouched limb posture, or a combination of these factors. To evaluate the mechanism underlying the loading regime of opossum femora, we filmed D. virginiana running over a force platform, allowing us to measure the magnitude of the GRF and its three-dimensional orientation relative to the limb, facilitating estimates of limb bone stresses. This three-dimensional analysis also allows evaluations of muscular forces, particularly those of hip adductor muscles, in the appropriate anatomical plane to a greater degree than previous two-dimensional analyses. At peak GRF and stress magnitudes, the GRF is oriented nearly vertically, inducing a strong abductor moment at the hip that is countered by adductor muscles on the medial aspect of the femur that place this surface in compression and induce mediolateral bending, corroborating and explaining loading patterns that were identified in strain analyses. The crouched orientation of the femur during stance in opossums also contributes to levels of femoral torsion as high as those seen in many reptilian taxa. Femoral safety factors were as high as those of non-avian reptiles and greater than those of upright, cursorial mammals, primarily because the load

  1. The M-2 ocean tide loading wave in Alaska: vertical and horizontal displacements, modelled and observed

    DEFF Research Database (Denmark)

    Khan, Shfaqat Abbas; Scherneck, H.G.

    2003-01-01

    Crustal deformations caused by surface load due to ocean tides are strongly dependent on the surface load closest to the observing site. In order to correctly model this ocean loading effect near irregular coastal areas, a high-resolution coastline is required. A test is carried out using two GPS...

  2. Crystal Plasticity Finite Element Analysis of Loading-Unloading Behaviour in Magnesium Alloy Sheet

    International Nuclear Information System (INIS)

    Hama, Takayuki; Fujimoto, Hitoshi; Takuda, Hirohiko

    2010-01-01

    Magnesium alloy sheets exhibit strong inelastic response during unloading. In this study crystal plasticity finite element analysis of loading-unloading behaviour during uniaxial tension in a rolled magnesium alloy sheet was carried out, and the mechanism of this inelastic response was examined in detail in terms of macroscopic and mesoscopic deformations. The unloading behaviour obtained by the simulation was in good agreement with the experiment in terms of variation with stress of instantaneous tangent modulus during unloading. Variations of activities of each family of slip systems during the deformation showed that the activation of basal slip systems is the largest during unloading, and the slip direction during unloading is opposite from during loading. These results indicated that one of the factors of the inelastic behaviour during unloading is the fact that the basal slip systems are easily activated during unloading because of their low strengths.

  3. Ocean Tide Loading Computation

    Science.gov (United States)

    Agnew, Duncan Carr

    2005-01-01

    September 15,2003 through May 15,2005 This grant funds the maintenance, updating, and distribution of programs for computing ocean tide loading, to enable the corrections for such loading to be more widely applied in space- geodetic and gravity measurements. These programs, developed under funding from the CDP and DOSE programs, incorporate the most recent global tidal models developed from Topex/Poscidon data, and also local tide models for regions around North America; the design of the algorithm and software makes it straightforward to combine local and global models.

  4. DYNAMIC LOAD DAMPER MODELING

    Directory of Open Access Journals (Sweden)

    Loktev Aleksey Alekseevich

    2013-01-01

    Full Text Available The authors present their findings associated with their modeling of a dynamic load damper. According to the authors, the damper is to be installed onto a structure or its element that may be exposed to impact, vibration or any other dynamic loading. The damper is composed of paralleled or consecutively connected viscous and elastic elements. The authors study the influence of viscosity and elasticity parameters of the damper produced onto the regular displacement of points of the structure to be protected and onto the regular acceleration transmitted immediately from the damper to the elements positioned below it.

  5. Linear operator inequalities for strongly stable weakly regular linear systems

    NARCIS (Netherlands)

    Curtain, RF

    2001-01-01

    We consider the question of the existence of solutions to certain linear operator inequalities (Lur'e equations) for strongly stable, weakly regular linear systems with generating operators A, B, C, 0. These operator inequalities are related to the spectral factorization of an associated Popov

  6. Concrete structures under impact loading: general aspects

    Directory of Open Access Journals (Sweden)

    Cornelia Baeră

    2016-09-01

    Full Text Available Dynamic loading conditions distress the structural integrity of a structure differently than the static ones. Such actions transfer high rate strains and instant energy waves to the structure, inducing the possibility of imminent collapse and casualties as a direct consequence. In the latest years, considering the dramatic increase of terrorist threats and global warming, the structural safety criteria imply more than ever the need to withstand this kind of loading (e.g., missiles and blast, projectiles, strong winds, tornados and earthquakes in addition to the static ones. The aim of this paper is to provide a general overview with regard to impact loading in terms of defining the phenomenon from physical and mechanical perspective, its complex local or global effect on the targeted structure, relevant material characteristics, main research approaches, namely theoretical studies and experimental procedures developed for improving the predictability of the dynamic loads and their effects. New directions in developing superior cementitious composites, with better characteristics in terms of dynamic loading performance are also emphasized.

  7. Strong Stationary Duality for Diffusion Processes

    OpenAIRE

    Fill, James Allen; Lyzinski, Vince

    2014-01-01

    We develop the theory of strong stationary duality for diffusion processes on compact intervals. We analytically derive the generator and boundary behavior of the dual process and recover a central tenet of the classical Markov chain theory in the diffusion setting by linking the separation distance in the primal diffusion to the absorption time in the dual diffusion. We also exhibit our strong stationary dual as the natural limiting process of the strong stationary dual sequence of a well ch...

  8. Strongly correlating liquids and their isomorphs

    OpenAIRE

    Pedersen, Ulf R.; Gnan, Nicoletta; Bailey, Nicholas P.; Schröder, Thomas B.; Dyre, Jeppe C.

    2010-01-01

    This paper summarizes the properties of strongly correlating liquids, i.e., liquids with strong correlations between virial and potential energy equilibrium fluctuations at constant volume. We proceed to focus on the experimental predictions for strongly correlating glass-forming liquids. These predictions include i) density scaling, ii) isochronal superposition, iii) that there is a single function from which all frequency-dependent viscoelastic response functions may be calculated, iv) that...

  9. Atom collisions in a strong electromagnetic field

    International Nuclear Information System (INIS)

    Smirnov, V.S.; Chaplik, A.V.

    1976-01-01

    It is shown that the long-range part of interatomic interaction is considerably altered in a strong electromagnetic field. Instead of the van der Waals law the potential asymptote can best be described by a dipole-dipole R -3 law. Impact broadening and the line shift in a strong nonresonant field are calculated. The possibility of bound states of two atoms being formed in a strong light field is discussed

  10. Lateral loadings on snubber assemblies

    International Nuclear Information System (INIS)

    Raphael, L.S.

    1981-01-01

    This paper examines the installation of snubber assemblies in power plants with respect to transverse or lateral loads as well as axial loads. Evaluation of the effects of low level, lateral loads was performed by analytical means. At higher loadings, the snubber assembly could no longer be treated as a column; therefore, the effects of lateral loadings was determined by test. The test consisted of applying both lateral and axial loads simultaneously. Results of both the analysis and the test showed that the application of lateral loads had a considerable effect on the snubber assemblies

  11. Determination of current loads of floating platform for special purposes

    Science.gov (United States)

    Ma, Guang-ying; Yao, Yun-long; Zhao, Chen-yao

    2017-08-01

    This article studied a new floating offshore platform for special purposes, which was assembled by standard floating modules. The environmental load calculation of the platform is an important part of the research of the ocean platform, which has always been paid attention to by engineers. In addition to wave loads, the wind loads and current loads are also important environmental factors that affect the dynamic response of the offshore platform. The current loads on the bottom structure should not be ignored. By Fluent software, the hydrostatic conditions and external current loads of the platform were calculated in this paper. The coefficient which is independent of the current velocity, namely, current force coefficient, can be fitted through current loads, which can be used for the consequent hydrodynamic and mooring analyses.

  12. Fuel Load (FL)

    Science.gov (United States)

    Duncan C. Lutes; Robert E. Keane

    2006-01-01

    The Fuel Load method (FL) is used to sample dead and down woody debris, determine depth of the duff/ litter profile, estimate the proportion of litter in the profile, and estimate total vegetative cover and dead vegetative cover. Down woody debris (DWD) is sampled using the planar intercept technique based on the methodology developed by Brown (1974). Pieces of dead...

  13. HIV Viral Load

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  14. Loading device for incinerator

    International Nuclear Information System (INIS)

    Hempelmann, W.

    1983-01-01

    An incinerator for radioactive waste is described. Heat radiation from the incinerator into the loading device is reduced by the design of the slider with a ceramic plate and the conical widening of the pot, and also by fixing a metal plate between the pot and the floor. (PW) [de

  15. Side loading filter apparatus

    International Nuclear Information System (INIS)

    Reynolds, K.E.

    1981-01-01

    A side loading filter chamber for use with radioactive gases is described. The equipment incorporates an inexpensive, manually operated, mechanism for aligning filter units with a number of laterally spaced wall openings and for removing the units from the chamber. (U.K.)

  16. EQUATING FACULTY LOADS.

    Science.gov (United States)

    OOSTING, KENNETH W.

    AT ALPENA COMMUNITY COLLEGE, A NORMAL TEACHING LOAD FOR ANY FACULTY MEMBER IS 14-16 SEMESTER HOURS, WITH 75-125 STUDENTS AND 2-3 PREPARATIONS. VARIATIONS FROM THE SCHEDULE ARE IN ACCORDANCE WITH SPECIFIC FORMULAS RELATING TO TOTAL MEMBERS OF STUDENTS, NUMBERS OF PREPARATIONS, ASSIGNMENT TO ENGLISH COMPOSITION CLASSES, NEW COURSES, AND CLASSES…

  17. Probabilistic Load Flow

    DEFF Research Database (Denmark)

    Chen, Peiyuan; Chen, Zhe; Bak-Jensen, Birgitte

    2008-01-01

    This paper reviews the development of the probabilistic load flow (PLF) techniques. Applications of the PLF techniques in different areas of power system steady-state analysis are also discussed. The purpose of the review is to identify different available PLF techniques and their corresponding...

  18. Duration of load revisited

    DEFF Research Database (Denmark)

    Hoffmeyer, Preben; Sørensen, John Dalsgaard

    2007-01-01

    A duration of load study representing 13 years of testing was recently terminated. Preliminary results have been published over the years. This paper represents the final account of the study, which was focused on the influ-ence of moisture content on time to failure for structural timber subject...

  19. Robust surgery loading

    NARCIS (Netherlands)

    Hans, Elias W.; Wullink, Gerhard; van Houdenhoven, Mark; Kazemier, Geert

    2008-01-01

    We consider the robust surgery loading problem for a hospital’s operating theatre department, which concerns assigning surgeries and sufficient planned slack to operating room days. The objective is to maximize capacity utilization and minimize the risk of overtime, and thus cancelled patients. This

  20. Temoporfin-loaded liposomes

    DEFF Research Database (Denmark)

    Kuntsche, Judith; Freisleben, Ines; Steiniger, Frank

    2010-01-01

    . In contrast, if phospholipids with longer fatty acid chains (distearoylphosphatidylcholine/-glycerol) were used, phase transitions were well above body temperature even at high drug load. Size and thermal behavior were not distinctly influenced by the addition of pegylated lipids but cryo-electron microscopic...