WorldWideScience

Sample records for stringent blasting requirements

  1. Flight Hardware Packaging Design for Stringent EMC Radiated Emission Requirements

    Science.gov (United States)

    Lortz, Charlene L.; Huang, Chi-Chien N.; Ravich, Joshua A.; Steiner, Carl N.

    2013-01-01

    This packaging design approach can help heritage hardware meet a flight project's stringent EMC radiated emissions requirement. The approach requires only minor modifications to a hardware's chassis and mainly concentrates on its connector interfaces. The solution is to raise the surface area where the connector is mounted by a few millimeters using a pedestal, and then wrapping with conductive tape from the cable backshell down to the surface-mounted connector. This design approach has been applied to JPL flight project subsystems. The EMC radiated emissions requirements for flight projects can vary from benign to mission critical. If the project's EMC requirements are stringent, the best approach to meet EMC requirements would be to design an EMC control program for the project early on and implement EMC design techniques starting with the circuit board layout. This is the ideal scenario for hardware that is built from scratch. Implementation of EMC radiated emissions mitigation techniques can mature as the design progresses, with minimal impact to the design cycle. The real challenge exists for hardware that is planned to be flown following a built-to-print approach, in which heritage hardware from a past project with a different set of requirements is expected to perform satisfactorily for a new project. With acceptance of heritage, the design would already be established (circuit board layout and components have already been pre-determined), and hence any radiated emissions mitigation techniques would only be applicable at the packaging level. The key is to take a heritage design with its known radiated emissions spectrum and repackage, or modify its chassis design so that it would have a better chance of meeting the new project s radiated emissions requirements.

  2. The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana.

    Science.gov (United States)

    Ravi, Maruthachalam; Kwong, Pak N; Menorca, Ron M G; Valencia, Joel T; Ramahi, Joseph S; Stewart, Jodi L; Tran, Robert K; Sundaresan, Venkatesan; Comai, Luca; Chan, Simon W-L

    2010-10-01

    Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CENP-A in human), which replaces histone H3 in centromeric nucleosomes. CENH3 evolves rapidly, particularly in its N-terminal tail domain. A portion of the CENH3 histone-fold domain, the CENP-A targeting domain (CATD), has been previously shown to confer kinetochore localization and centromere function when swapped into human H3. Furthermore, CENP-A in human cells can be functionally replaced by CENH3 from distantly related organisms including Saccharomyces cerevisiae. We have used cenh3-1 (a null mutant in Arabidopsis thaliana) to replace endogenous CENH3 with GFP-tagged variants. A H3.3 tail domain-CENH3 histone-fold domain chimera rescued viability of cenh3-1, but CENH3's lacking a tail domain were nonfunctional. In contrast to human results, H3 containing the A. thaliana CATD cannot complement cenh3-1. GFP-CENH3 from the sister species A. arenosa functionally replaces A. thaliana CENH3. GFP-CENH3 from the close relative Brassica rapa was targeted to centromeres, but did not complement cenh3-1, indicating that kinetochore localization and centromere function can be uncoupled. We conclude that CENH3 function in A. thaliana, an organism with large tandem repeat centromeres, has stringent requirements for functional complementation in mitosis.

  3. Waste management from reprocessing: a stringent regulatory requirements for high quality conditioned residues

    International Nuclear Information System (INIS)

    Bordier, J. C.; Greneche, D.; Devezeaux, J. G.; Dalcorso, J.

    2000-01-01

    Nuclear waste production and management in France is governed by safety requirements imposed to all operators. French nuclear safety relies on two basic principles: · Responsibility of the nuclear operator, which expands to waste generated, · Safety basic objectives issued by national Safety Authority. For a long time the regulatory framework for waste production and management has been satisfactorily applied and has benefited to each actor of the process. LLW/MLW and HLW nuclear waste are currently conditioned in safe matrices or packages either likely to be disposed in surface repositories or designed with the intention to be disposed underground according to their radioactive content. France is looking into the case of VLLW and has already carried out a design for future disposal, the design being in the pipe. Other types of waste (i. e. radium bearing waste, graphite, and tritium content waste) are also considered in the whole framework of French waste management. (author)

  4. The Impact on IPO Performance of More Stringent Listing Rules with a Pre-listing Earnings Requirement: Evidence from Hong Kong

    OpenAIRE

    Wai-yan Cheng; Yan-leung Cheung; Yuen-ching Tse

    2005-01-01

    This study considers the impact of a change to listing rules covering IPO performance in the Hong Kong stock market. The change, introduced in 1994, imposed a three-year pre-listing earning requirement on new issues. The objective of this research is to screen out a subset of poor IPO performers. We find there is no significant difference in performance between IPOs before and after the regulatory change. We further divide our sample of IPOs registered before the regulatory change into two su...

  5. Design of blast-loaded glazing windows and facades: A review of essential requirements towards standardization

    NARCIS (Netherlands)

    Larcher, M.; Arrigoni, M.; Bedon, C.; Doormaal, J.C.A.M. van; Haberacker, C.; Hüsken, G.; Millon, O.; Saarenheimo, A.; Solomos, G.; Thamie, L.; Valsamos, G.; Williams, A.; Stolz, A.

    2016-01-01

    The determination of the blast protection level of laminated glass windows and facades is of crucial importance, and it is normally done by using experimental investigations. In recent years numerical methods have become much more powerful also with respect to this kind of application. This paper

  6. Design of Blast-Loaded Glazing Windows and Facades: A Review of Essential Requirements towards Standardization

    Directory of Open Access Journals (Sweden)

    Martin Larcher

    2016-01-01

    Full Text Available The determination of the blast protection level of laminated glass windows and facades is of crucial importance, and it is normally done by using experimental investigations. In recent years numerical methods have become much more powerful also with respect to this kind of application. This paper attempts to give a first idea of a possible standardization concerning such numerical simulations. Attention is drawn to the representation of the blast loading and to the proper description of the behaviour of the material of the mentioned products, to the geometrical meshing, and to the modelling of the connections of the glass components to the main structure. The need to validate the numerical models against reliable experimental data, some of which are indicated, is underlined.

  7. An analysis of the heap construction by long hole blasting for in-situ leaching of blasted ore

    International Nuclear Information System (INIS)

    Yang Shijiao

    1999-01-01

    The author establishes specific requirements for heap construction by blasting on the basis of the mechanism for in situ leaching of blasted ore, analyses the feasibility of heap construction by long hole blasting, selection of the blast plan and the relevant technological problems, and gives a case of heap construction by long hole blasting in Renhua uranium mine

  8. Blast Technologies

    Science.gov (United States)

    2011-06-27

    Team Leader Risa Scherer Blast Mitigation Interior and Laboratory Team Leader Blast Technologies POC’s Government Point Of Contacts (POCs): To...to yield injury assessments at higher fidelities and with higher confidence UNCLASSIFIED UNCLASSIFIED Risa Scherer Blast Mitigation Interior and

  9. BLEVE blast by expansion-controlled evaporation

    NARCIS (Netherlands)

    Berg, A.C. van den; Voort, M.M. van der; Weerheijm, J.; Versloot, N.H.A.

    2006-01-01

    This report presents a new method to calculate the blast effects originating from an exploding vessel of liquefied gas. Adequate blast calculation requires full knowledge of the blast source characteristics, that is, the release and subsequent evaporation rate of the flashing liquid. Because the

  10. A set of essential requirements towards standardising the numerical simulation of blast-loaded windows and facades

    NARCIS (Netherlands)

    Larcher, M.; Stolz, A.; Millon, O.; Bedon, C.; C, K.; Doormaal, J.C.A.M. van; Haberacker, C.; Hüsken, G.; Larcher, M.; Millon, O.; Saarenheimo, A.; Solomos, G.; Stolz, A.; Thamie, L.; Valsamos, G.; Williams, A.

    2015-01-01

    The determination of the blast protection level of laminated glass windows and facades is of crucial importance, and it is normally done by using experimental investigations. In recent years numerical methods have become much more powerful also with respect to this kind of application. This report

  11. Control blasting of reinforced concrete

    International Nuclear Information System (INIS)

    Nagase, Tetsuo

    1981-01-01

    With the need of decommissioning nuclear power plants, it is urgently required to establish its methods and standards. In Shimizu Construction Co., Ltd., experimental feasibility studies have been made on explosive demolition method i.e. the controlled blasting for the massive concrete structures peculiar to nuclear power plants, considering low radiation exposure, safety and high efficiency. As such, four techniques of line drilling, cushion blasting, pre-splitting and guide hole blasting, respectively, are described with photographs. Assuming the selective demolition of activated concrete structures, the series of experiments showed the good results of clear-cut surfaces and the effect of blasting was confined properly. Moreover, the scattering of debris in blasting was able to be entirely prevented by the use of rubber belts. The generation of gas and dust was also little due to the small amount of the charge used. (J.P.N.)

  12. The effect of increasingly stringent diagnostic criteria on sex ...

    African Journals Online (AJOL)

    Sex differences in premorbid function and symptomatology were examined as increasingly stringent criteria for schizophrenia were applied to 182 male and 139 female . psychotic patients. The male/female ratio rose from 1.6 among those meeting the CATEGO 'broad' criteria for schizophrenia to 3.7 among those satisfying ...

  13. Circuitry linking the Csr and stringent response global regulatory systems.

    Science.gov (United States)

    Edwards, Adrianne N; Patterson-Fortin, Laura M; Vakulskas, Christopher A; Mercante, Jeffrey W; Potrykus, Katarzyna; Vinella, Daniel; Camacho, Martha I; Fields, Joshua A; Thompson, Stuart A; Georgellis, Dimitris; Cashel, Michael; Babitzke, Paul; Romeo, Tony

    2011-06-01

    CsrA protein regulates important cellular processes by binding to target mRNAs and altering their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC, which sequester CsrA and antagonize its activity. Here, mRNAs for relA, spoT and dksA of the stringent response system were found among 721 different transcripts that copurified with CsrA. Many of the transcripts that copurified with CsrA were previously determined to respond to ppGpp and/or DksA. We examined multiple regulatory interactions between the Csr and stringent response systems. Most importantly, DksA and ppGpp robustly activated csrB/C transcription (10-fold), while they modestly activated csrA expression. We propose that CsrA-mediated regulation is relieved during the stringent response. Gel shift assays confirmed high affinity binding of CsrA to relA mRNA leader and weaker interactions with dksA and spoT. Reporter fusions, qRT-PCR and immunoblotting showed that CsrA repressed relA expression, and (p)ppGpp accumulation during stringent response was enhanced in a csrA mutant. CsrA had modest to negligible effects on dksA and spoT expression. Transcription of dksA was negatively autoregulated via a feedback loop that tended to mask CsrA effects. We propose that the Csr system fine-tunes the stringent response and discuss biological implications of the composite circuitry. © Published 2011. This article is a US Government work and is in the public domain in the USA.

  14. Blast Waves

    CERN Document Server

    Needham, Charles E

    2010-01-01

    The primary purpose of this text is to document many of the lessons that have been learned during the author’s more than forty years in the field of blast and shock. The writing therefore takes on an historical perspective, in some sense, because it follows the author’s experience. The book deals with blast waves propagating in fluids or materials that can be treated as fluids. It begins by distinguishing between blast waves and the more general category of shock waves. It then examines several ways of generating blast waves, considering the propagation of blast waves in one, two and three dimensions as well as through the real atmosphere. One section treats the propagation of shocks in layered gases in a more detailed manner. The book also details the interaction of shock waves with structures in particular reflections, progressing from simple to complex geometries, including planar structures, two-dimensional structures such as ramps or wedges, reflections from heights of burst, and three-dimensional st...

  15. Is ionizing radiation regulated more stringently than chemical carcinogens

    International Nuclear Information System (INIS)

    Travis, C.C.; Pack, S.R.; Hattemer-Frey, H.A.

    1989-01-01

    It is widely believed that United States government agencies regulate exposure to ionizing radiation more stringently than exposure to chemical carcinogens. It is difficult to verify this perception, however, because chemical carcinogens and ionizing radiation are regulated using vastly different strategies. Chemical carcinogens are generally regulated individually. Regulators consider the risk of exposure to one chemical rather than the cumulative radiation exposure from all sources. Moreover, standards for chemical carcinogens are generally set in terms of quantities released or resultant environmental concentrations, while standards for ionizing radiation are set in terms of dose to the human body. Since chemicals and ionizing radiation cannot be compared on the basis of equal dose to the exposed individual, standards regulating chemicals and ionizing radiation cannot be compared directly. It is feasible, however, to compare the two sets of standards on the basis of equal risk to the exposed individual, assuming that standards for chemicals and ionizing radiation are equivalent if estimated risk levels are equitable. This paper compares risk levels associated with current standards for ionizing radiation and chemical carcinogens. The authors do not attempt to determine whether either type of risk is regulated too stringently or not stringently enough but endeavor only to ascertain if ionizing radiation is actually regulated more strictly than chemical carcinogens

  16. CrocoBLAST: Running BLAST efficiently in the age of next-generation sequencing.

    Science.gov (United States)

    Tristão Ramos, Ravi José; de Azevedo Martins, Allan Cézar; da Silva Delgado, Gabrielle; Ionescu, Crina-Maria; Ürményi, Turán Peter; Silva, Rosane; Koca, Jaroslav

    2017-11-15

    CrocoBLAST is a tool for dramatically speeding up BLAST+ execution on any computer. Alignments that would take days or weeks with NCBI BLAST+ can be run overnight with CrocoBLAST. Additionally, CrocoBLAST provides features critical for NGS data analysis, including: results identical to those of BLAST+; compatibility with any BLAST+ version; real-time information regarding calculation progress and remaining run time; access to partial alignment results; queueing, pausing, and resuming BLAST+ calculations without information loss. CrocoBLAST is freely available online, with ample documentation (webchem.ncbr.muni.cz/Platform/App/CrocoBLAST). No installation or user registration is required. CrocoBLAST is implemented in C, while the graphical user interface is implemented in Java. CrocoBLAST is supported under Linux and Windows, and can be run under Mac OS X in a Linux virtual machine. jkoca@ceitec.cz. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  17. Porcine head response to blast

    Directory of Open Access Journals (Sweden)

    Jay eShridharani

    2012-05-01

    Full Text Available Recent studies have shown an increase in the frequency of traumatic brain injuries related to blast exposure. However, the mechanisms that cause blast neurotrauma are unknown. Blast neurotrauma research using computational models has been one method to elucidate that response of the brain in blast, and to identify possible mechanical correlates of injury. However, model validation against experimental data is required to ensure that the model output is representative of in vivo biomechanical response. This study exposed porcine subjects to primary blast overpressures generated using a compressed-gas shock tube. Shock tube blasts were directed to the unprotected head of each animal while the lungs and thorax were protected using ballistic protective vests similar to those employed in theater. The test conditions ranged from 110-740 kPa peak incident overpressure with scaled durations from 1.3-6.9 ms and correspond approximately with a 50% injury risk for brain bleeding and apnea in a ferret model scaled to porcine exposure. The bulk head acceleration and the pressure at the surface of the head and in the cranial cavity were measured. Immediately after the blast, 5 of the 20 animals tested were apneic. Three subjects recovered without intervention within thirty seconds and the remaining two recovered within 8 minutes following bagging and administration of the respiratory stimulant doxapram. Gross examination of the brain revealed no indication of bleeding. Intracranial pressures ranged from 80-685 kPa as a result of the blast and were notably lower than the shock tube reflected pressures of 300-2830 kPa, indicating pressure attenuation by the skull up to a factor of 8.4. Peak head accelerations were measured from 385-3845 G’s and were well correlated with peak incident overpressure (R2=0.90. One standard deviation corridors for the surface pressure, intracranial pressure, and head acceleration are presented to provide experimental data for

  18. HYR1-mediated detoxification of reactive oxygen species is required for full virulence in the rice blast fungus.

    Directory of Open Access Journals (Sweden)

    Kun Huang

    2011-04-01

    Full Text Available During plant-pathogen interactions, the plant may mount several types of defense responses to either block the pathogen completely or ameliorate the amount of disease. Such responses include release of reactive oxygen species (ROS to attack the pathogen, as well as formation of cell wall appositions (CWAs to physically block pathogen penetration. A successful pathogen will likely have its own ROS detoxification mechanisms to cope with this inhospitable environment. Here, we report one such candidate mechanism in the rice blast fungus, Magnaporthe oryzae, governed by a gene we refer to as MoHYR1. This gene (MGG_07460 encodes a glutathione peroxidase (GSHPx domain, and its homologue in yeast was reported to specifically detoxify phospholipid peroxides. To characterize this gene in M. oryzae, we generated a deletion mutantΔhyr1 which showed growth inhibition with increased amounts of hydrogen peroxide (H₂O₂. Moreover, we observed that the fungal mutants had a decreased ability to tolerate ROS generated by a susceptible plant, including ROS found associated with CWAs. Ultimately, this resulted in significantly smaller lesion sizes on both barley and rice. In order to determine how this gene interacts with other (ROS scavenging-related genes in M. oryzae, we compared expression levels of ten genes in mutant versus wild type with and without H₂O₂. Our results indicated that the HYR1 gene was important for allowing the fungus to tolerate H₂O₂ in vitro and in planta and that this ability was directly related to fungal virulence.

  19. Comparison of urine iodine/creatinine ratio between patients following stringent and less stringent low iodine diet for radioiodine remnant ablation of thyroid cancer

    International Nuclear Information System (INIS)

    Roh, Jee Ho; Kim, Byung Il; Ha, Ji Su; Chang, Sei Joong; Shin, Hye Young; Choi, Joon Hyuk; Kim, Do Min; Kim, Chong Soon

    2006-01-01

    A low iodine diet (LID) for 1 ∼ 2 weeks is recommended for patients who undergoing radioiodine remnant ablation. However, the LID educations for patients are different among centers because there is no concrete recommendation for protocol of LID. In this investigation, we compared two representative types of LID protocols performed in several centers in Korea using urine iodine to creatinine tatio (urine I/Cr). From 2006, April to June, patients referred to our center for radioiodine remnant ablation of thyroid cancer from several local hospitals which had different LID protocols were included. We divided into two groups, stringent LID for 1 week and less stringent LID for 2 weeks, then measured their urine I/Cr ratio with spot urine when patients were admitted to the hospital. Total 27 patients were included in this investigation (M:F = 1:26; 13 in one-week stringent LID; 14 in two-week less stringent LID). Average of urine I/Cr ratio was 127.87 ± 78.52 μ g/g in stringent LID for 1 week, and 289.75 ± 188.24 μ g/g in less stringent LID for 2 weeks. It was significantly lower in stringent LID for 1 week group (ρ = 0.008). The number of patients whose urine I/Cr ratios were below 100 μ g/g was 6 of 13 in stringent LID for 1 week group, and 3 of 14 in less stringent LID for 2 weeks group. Stringent LID for 1 week resulted in better urinary I/Cr ratio in our investigation compared with the other protocol. However it still resulted in plenty of inadequate range of I/Cr ratio, so more stringent protocol such as stringent LID for 2 weeks is expected more desirable

  20. One of Three Pex11 Family Members Is Required for Peroxisomal Proliferation and Full Virulence of the Rice Blast Fungus Magnaporthe oryzae.

    Directory of Open Access Journals (Sweden)

    Jiaoyu Wang

    Full Text Available Peroxisomes play important roles in metabolisms of eukaryotes and infection of plant fungal pathogens. These organelles proliferate by de novo formation or division in response to environmental stimulation. Although the assembly of peroxisomes was documented in fungal pathogens, their division and its relationship to pathogenicity remain obscure. In present work, we analyzed the roles of three Pex11 family members in peroxisomal division and pathogenicity of the rice blast fungus Magnaporthe oryzae. Deletion of MoPEX11A led to fewer but enlarged peroxisomes, and impaired the separation of Woronin bodies from peroxisomes, while deletion of MoPEX11B or MoPEX11C put no evident impacts to peroxisomal profiles. MoPEX11A mutant exhibited typical peroxisome related defects, delayed conidial germination and appressoria formation, and decreased appressorial turgor and host penetration. As a result, the virulence of MoPEX11A mutant was greatly reduced. Deletion of MoPEX11B and MoPEX11C did not alter the virulence of the fungus. Further, double or triple deletions of the three genes were unable to enhance the virulence decrease in MoPEX11A mutant. Our data indicated that MoPEX11A is the main factor modulating peroxisomal division and is required for full virulence of the fungus.

  1. Simulating geometrically complex blast scenarios

    Directory of Open Access Journals (Sweden)

    Ian G. Cullis

    2016-04-01

    Full Text Available The effects of blast waves generated by energetic and non-energetic sources are of continuing interest to the ballistics research community. Modern conflicts are increasingly characterised by asymmetric urban warfare, with improvised explosive devices (IEDs often playing a dominant role on the one hand and an armed forces requirement for minimal collateral effects from their weapons on the other. These problems are characterised by disparate length- and time-scales and may also be governed by complex physics. There is thus an increasing need to be able to rapidly assess and accurately predict the effects of energetic blast in topologically complex scenarios. To this end, this paper presents a new QinetiQ-developed advanced computational package called EAGLE-Blast, which is capable of accurately resolving the generation, propagation and interaction of blast waves around geometrically complex shapes such as vehicles and buildings. After a brief description of the numerical methodology, various blast scenario simulations are described and the results compared with experimental data to demonstrate the validation of the scheme and its ability to describe these complex scenarios accurately and efficiently. The paper concludes with a brief discussion on the use of the code in supporting the development of algorithms for fast running engineering models.

  2. Systematic analysis of Zn2Cys6 transcription factors required for development and pathogenicity by high-throughput gene knockout in the rice blast fungus.

    Directory of Open Access Journals (Sweden)

    Jianping Lu

    2014-10-01

    Full Text Available Because of great challenges and workload in deleting genes on a large scale, the functions of most genes in pathogenic fungi are still unclear. In this study, we developed a high-throughput gene knockout system using a novel yeast-Escherichia-Agrobacterium shuttle vector, pKO1B, in the rice blast fungus Magnaporthe oryzae. Using this method, we deleted 104 fungal-specific Zn(2Cys(6 transcription factor (TF genes in M. oryzae. We then analyzed the phenotypes of these mutants with regard to growth, asexual and infection-related development, pathogenesis, and 9 abiotic stresses. The resulting data provide new insights into how this rice pathogen of global significance regulates important traits in the infection cycle through Zn(2Cys(6TF genes. A large variation in biological functions of Zn(2Cys(6TF genes was observed under the conditions tested. Sixty-one of 104 Zn(2Cys(6 TF genes were found to be required for fungal development. In-depth analysis of TF genes revealed that TF genes involved in pathogenicity frequently tend to function in multiple development stages, and disclosed many highly conserved but unidentified functional TF genes of importance in the fungal kingdom. We further found that the virulence-required TF genes GPF1 and CNF2 have similar regulation mechanisms in the gene expression involved in pathogenicity. These experimental validations clearly demonstrated the value of a high-throughput gene knockout system in understanding the biological functions of genes on a genome scale in fungi, and provided a solid foundation for elucidating the gene expression network that regulates the development and pathogenicity of M. oryzae.

  3. Role of the Stringent Stress Response in the Antibiotic Resistance Phenotype of Methicillin-Resistant Staphylococcus aureus.

    Science.gov (United States)

    Aedo, Sandra; Tomasz, Alexander

    2016-04-01

    Resistance to beta-lactam antibiotics in methicillin-resistantStaphylococcus aureus(MRSA) requires the presence of an acquired genetic determinant,mecAormecC, which encode penicillin-binding protein PBP2A or PBP2A', respectively. Although all MRSA strains share a mechanism of resistance, the phenotypic expression of beta-lactam resistance shows considerable strain-to-strain variation. The stringent stress response, a stress response that results from nutrient limitation, was shown to play a key role in determining the resistance level of an MRSA strain. In the present study, we validated the impact of the stringent stress response on transcription and translation ofmecAin the MRSA clinical isolate strain N315, which also carries known regulatory genes (mecI/mecR1/mecR2andblaI/blaR1) formecAtranscription. We showed that the impact of the stringent stress response on the resistance level may be restricted to beta-lactam resistance based on a "foreign" determinant such asmecA, as opposed to resistance based on mutations in the nativeS. aureusdeterminantpbpB(encoding PBP2). Our observations demonstrate that high-level resistance mediated by the stringent stress response follows the current model of beta-lactam resistance in which the native PBP2 protein is also essential for expression of the resistance phenotype. We also show that theStaphylococcus sciuri pbpDgene (also calledmecAI), the putative evolutionary precursor ofmecA, confers oxacillin resistance in anS. aureusstrain, generating a heterogeneous phenotype that can be converted to high and homogenous resistance by induction of the stringent stress response in the bacteria. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  4. SparkBLAST: scalable BLAST processing using in-memory operations.

    Science.gov (United States)

    de Castro, Marcelo Rodrigo; Tostes, Catherine Dos Santos; Dávila, Alberto M R; Senger, Hermes; da Silva, Fabricio A B

    2017-06-27

    The demand for processing ever increasing amounts of genomic data has raised new challenges for the implementation of highly scalable and efficient computational systems. In this paper we propose SparkBLAST, a parallelization of a sequence alignment application (BLAST) that employs cloud computing for the provisioning of computational resources and Apache Spark as the coordination framework. As a proof of concept, some radionuclide-resistant bacterial genomes were selected for similarity analysis. Experiments in Google and Microsoft Azure clouds demonstrated that SparkBLAST outperforms an equivalent system implemented on Hadoop in terms of speedup and execution times. The superior performance of SparkBLAST is mainly due to the in-memory operations available through the Spark framework, consequently reducing the number of local I/O operations required for distributed BLAST processing.

  5. Ultra Safe And Secure Blasting System

    Energy Technology Data Exchange (ETDEWEB)

    Hart, M M

    2009-07-27

    The Ultra is a blasting system that is designed for special applications where the risk and consequences of unauthorized demolition or blasting are so great that the use of an extraordinarily safe and secure blasting system is justified. Such a blasting system would be connected and logically welded together through digital code-linking as part of the blasting system set-up and initialization process. The Ultra's security is so robust that it will defeat the people who designed and built the components in any attempt at unauthorized detonation. Anyone attempting to gain unauthorized control of the system by substituting components or tapping into communications lines will be thwarted in their inability to provide encrypted authentication. Authentication occurs through the use of codes that are generated by the system during initialization code-linking and the codes remain unknown to anyone, including the authorized operator. Once code-linked, a closed system has been created. The system requires all components connected as they were during initialization as well as a unique code entered by the operator for function and blasting.

  6. Robotic Water Blast Cleaner

    Science.gov (United States)

    Sharpe, M. H.; Roberts, M. L.; Hill, W. E.; Jackson, C. H.

    1983-01-01

    Water blasting system under development removes hard, dense, extraneous material from surfaces. High pressure pump forces water at supersonic speed through nozzle manipulated by robot. Impact of water blasts away unwanted material from workpiece rotated on air bearing turntable. Designed for removing thermal-protection material, system is adaptable to such industrial processes as cleaning iron or steel castings.

  7. Single point methods for determining blast wave injury

    NARCIS (Netherlands)

    Teland, J.A.; Doormaal, J.C.A.M. van; Horst, M.J. van der; Svinsas, E.

    2011-01-01

    Models for calculating human injury from a blast wave are examined. The Axelsson BTD model is able to give injury estimates also for complex shock waves, but is difficult to use in practise since it requires input from four pressure sensors on a BTD (Blast Test Device) in the specific location. To

  8. Blasting Standards for the Ghanaian Mining Industry | Amegbey ...

    African Journals Online (AJOL)

    Ghana is a well known mining nation and hard rock mining has been going on since the 10th century. Mining companies in Ghana are well aware of the regulatory requirements to carry out blasting activities such that neighbouring communities are protected from excessive impact as a result of blast vibrations amongst other ...

  9. Rapid species responses to changes in climate require stringent climate protection targets

    NARCIS (Netherlands)

    Vliet, van A.J.H.; Leemans, R.

    2006-01-01

    The Avoiding Dangerous Climate Change book consolidates the scientific findings of the Exeter conference and gives an account of the most recent developments on critical thresholds and key vulnerabilities of the climate system, impacts on human and natural systems, emission pathways and

  10. A rapid response air quality analysis system for use in projects having stringent quality assurance requirements

    International Nuclear Information System (INIS)

    Bowman, A.W.

    1990-01-01

    This paper describes an approach to solve air quality problems which frequently occur during iterations of the baseline change process. From a schedule standpoint, it is desirable to perform this evaluation in as short a time as possible while budgetary pressures limit the size of the staff available to do the work. Without a method in place to deal with baseline change proposal requests the environment analysts may not be able to produce the analysis results in the time frame expected. Using a concept called the Rapid Response Air Quality Analysis System (RAAS), the problems of timing and cost become tractable. The system could be adapted to assess other atmospheric pathway impacts, e.g., acoustics or visibility. The air quality analysis system used to perform the EA analysis (EA) for the Salt Repository Project (part of the Civilian Radioactive Waste Management Program), and later to evaluate the consequences of proposed baseline changes, consists of three components: Emission source data files; Emission rates contained in spreadsheets; Impact assessment model codes. The spreadsheets contain user-written codes (macros) that calculate emission rates from (1) emission source data (e.g., numbers and locations of sources, detailed operating schedules, and source specifications including horsepower, load factor, and duty cycle); (2) emission factors such as those published by the U.S. Environmental Protection Agency, and (3) control efficiencies

  11. Divide and Conquer (DC BLAST: fast and easy BLAST execution within HPC environments

    Directory of Open Access Journals (Sweden)

    Won Cheol Yim

    2017-06-01

    Full Text Available Bioinformatics is currently faced with very large-scale data sets that lead to computational jobs, especially sequence similarity searches, that can take absurdly long times to run. For example, the National Center for Biotechnology Information (NCBI Basic Local Alignment Search Tool (BLAST and BLAST+ suite, which is by far the most widely used tool for rapid similarity searching among nucleic acid or amino acid sequences, is highly central processing unit (CPU intensive. While the BLAST suite of programs perform searches very rapidly, they have the potential to be accelerated. In recent years, distributed computing environments have become more widely accessible and used due to the increasing availability of high-performance computing (HPC systems. Therefore, simple solutions for data parallelization are needed to expedite BLAST and other sequence analysis tools. However, existing software for parallel sequence similarity searches often requires extensive computational experience and skill on the part of the user. In order to accelerate BLAST and other sequence analysis tools, Divide and Conquer BLAST (DCBLAST was developed to perform NCBI BLAST searches within a cluster, grid, or HPC environment by using a query sequence distribution approach. Scaling from one (1 to 256 CPU cores resulted in significant improvements in processing speed. Thus, DCBLAST dramatically accelerates the execution of BLAST searches using a simple, accessible, robust, and parallel approach. DCBLAST works across multiple nodes automatically and it overcomes the speed limitation of single-node BLAST programs. DCBLAST can be used on any HPC system, can take advantage of hundreds of nodes, and has no output limitations. This freely available tool simplifies distributed computation pipelines to facilitate the rapid discovery of sequence similarities between very large data sets.

  12. Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Encoded mRNases

    DEFF Research Database (Denmark)

    Tian, Chengzhe; Roghanian, Mohammad; Jørgensen, Mikkel Girke

    2016-01-01

    Escherichia coli regulates its metabolism to adapt to changes in the environment, in particular to stressful downshifts in nutrient quality. Such shifts elicit the so-called stringent response coordinated by the alarmone guanosine tetra- and pentaphosphate [(p)ppGpp]. At sudden amino-acid (aa......RNase-encoding TA modules present in the wt strain. This observation suggested that toxins are part of the negative feedback to control the (p)ppGpp level during early stringent response. We built a ribosome trafficking model to evaluate the fold of increase in the RelA activity just after the onset of aa...... %. IMPORTANCE: The early stringent response elicited by amino-acid starvation is controlled by a sharp increase of the cellular (p)ppGpp level. Toxin-antitoxin encoded mRNases are activated by (p)ppGpp through enhanced degradation of antitoxins. The present work shows that this activation happens at a very...

  13. Phylogenetic analysis of proteins involved in the stringent response in plant cells.

    Science.gov (United States)

    Ito, Doshun; Ihara, Yuta; Nishihara, Hidenori; Masuda, Shinji

    2017-07-01

    The nucleotide (p)ppGpp is a second messenger that controls the stringent response in bacteria. The stringent response modifies expression of a large number of genes and metabolic processes and allows bacteria to survive under fluctuating environmental conditions. Recent genome sequencing analyses have revealed that genes responsible for the stringent response are also found in plants. These include (p)ppGpp synthases and hydrolases, RelA/SpoT homologs (RSHs), and the pppGpp-specific phosphatase GppA/Ppx. However, phylogenetic relationship between enzymes involved in bacterial and plant stringent responses is as yet generally unclear. Here, we investigated the origin and evolution of genes involved in the stringent response in plants. Phylogenetic analysis and primary structures of RSH homologs from different plant phyla (including Embryophyta, Charophyta, Chlorophyta, Rhodophyta and Glaucophyta) indicate that RSH gene families were introduced into plant cells by at least two independent lateral gene transfers from the bacterial Deinococcus-Thermus phylum and an unidentified bacterial phylum; alternatively, they were introduced into a proto-plant cell by a lateral gene transfer from the endosymbiotic cyanobacterium followed by gene loss of an ancestral RSH gene in the cyanobacterial linage. Phylogenetic analysis of gppA/ppx families indicated that plant gppA/ppx homologs form an individual cluster in the phylogenetic tree, and show a sister relationship with some bacterial gppA/ppx homologs. Although RSHs contain a plastidial transit peptide at the N terminus, GppA/Ppx homologs do not, suggesting that plant GppA/Ppx homologs function in the cytosol. These results reveal that a proto-plant cell obtained genes for the stringent response by lateral gene transfer events from different bacterial phyla and have utilized them to control metabolism in plastids and the cytosol.

  14. Blasting response of the Eiffel Tower

    Science.gov (United States)

    Horlyck, Lachlan; Hayes, Kieran; Caetano, Ryan; Tahmasebinia, Faham; Ansourian, Peter; Alonso-Marroquin, Fernando

    2016-08-01

    A finite element model of the Eiffel Tower was constructed using Strand7 software. The model replicates the existing tower, with dimensions justified through the use of original design drawings. A static and dynamic analysis was conducted to determine the actions of the tower under permanent, imposed and wind loadings, as well as under blast pressure loads and earthquake loads due to an explosion. It was observed that the tower utilises the full axial capacity of individual members by acting as a `truss of trusses'. As such, permanent and imposed loads are efficiently transferred to the primary columns through compression, while wind loads induce tensile forces in the windward legs and compressive forces in the leeward. Under blast loading, the tower experienced both ground vibrations and blast pressures. Ground vibrations induced a negligibly small earthquake loading into the structure which was ignored in subsequent analyses. The blast pressure was significant, and a dynamic analysis of this revealed that further research is required into the damping qualities of the structure due to soil and mechanical properties. In the worst case scenario, the blast was assumed to completely destroy several members in the adjacent leg. Despite this weakened condition, it was observed that the tower would still be able to sustain static loads, at least for enough time for occupant evacuation. Further, an optimised design revealed the structure was structurally sound under a 46% reduction of the metal tower's mass.

  15. Spalling of concrete subjected to blast loading

    Directory of Open Access Journals (Sweden)

    Foglar M.

    2013-09-01

    Full Text Available This paper presents outcomes of the blast field tests of FRC and reinforced concrete specimens, which were performed in cooperation with the Czech Army corps and Police of the Czech Republic in the military training area Boletice. The numerical evaluation of the experiments focused on the spalling of concrete subjected to blast loading started after the first set of the tests, took almost 3 years and required further small-scale experiments performed in the labs of the Czech Technical University.

  16. Numerical modeling and characterization of blast waves for application in blast-induced mild traumatic brain injury research

    Science.gov (United States)

    Phillips, Michael G.

    Human exposure to blast waves, including blast-induced traumatic brain injury, is a developing field in medical research. Experiments with explosives have many disadvantages including safety, cost, and required area for trials. Shock tubes provide an alternative method to produce free field blast wave profiles. A compressed nitrogen shock tube experiment instrumented with static and reflective pressure taps is modeled using a numerical simulation. The geometry of the numerical model is simplified and blast wave characteristics are derived based upon static and pressure profiles. The pressure profiles are analyzed along the shock tube centerline and radially away from the tube axis. The blast wave parameters found from the pressure profiles provide guidelines for spatial location of a specimen. The location could be based on multiple parameters and provides a distribution of anticipated pressure profiles experience by the specimen.

  17. Tpc1 is an important Zn(II2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus.

    Directory of Open Access Journals (Sweden)

    Rita Galhano

    2017-07-01

    Full Text Available The establishment of polarity is a critical process in pathogenic fungi, mediating infection-related morphogenesis and host tissue invasion. Here, we report the identification of TPC1 (Transcription factor for Polarity Control 1, which regulates invasive polarized growth in the rice blast fungus Magnaporthe oryzae. TPC1 encodes a putative transcription factor of the fungal Zn(II2Cys6 family, exclusive to filamentous fungi. Tpc1-deficient mutants show severe defects in conidiogenesis, infection-associated autophagy, glycogen and lipid metabolism, and plant tissue colonisation. By tracking actin-binding proteins, septin-5 and autophagosome components, we show that Tpc1 regulates cytoskeletal dynamics and infection-associated autophagy during appressorium-mediated plant penetration. We found that Tpc1 interacts with Mst12 and modulates its DNA-binding activity, while Tpc1 nuclear localisation also depends on the MAP kinase Pmk1, consistent with the involvement of Tpc1 in this signalling pathway, which is critical for appressorium development. Importantly, Tpc1 directly regulates NOXD expression, the p22phox subunit of the fungal NADPH oxidase complex via an interaction with Mst12. Tpc1 therefore controls spatial and temporal regulation of cortical F-actin through regulation of the NADPH oxidase complex during appressorium re-polarisation. Consequently, Tpc1 is a core developmental regulator in filamentous fungi, linking the regulated synthesis of reactive oxygen species and the Pmk1 pathway, with polarity control during host invasion.

  18. The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus.

    Science.gov (United States)

    Hood, Rachel D; Higgins, Sean A; Flamholz, Avi; Nichols, Robert J; Savage, David F

    2016-08-16

    The cyanobacterium Synechococcus elongatus relies upon photosynthesis to drive metabolism and growth. During darkness, Synechococcus stops growing, derives energy from its glycogen stores, and greatly decreases rates of macromolecular synthesis via unknown mechanisms. Here, we show that the stringent response, a stress response pathway whose genes are conserved across bacteria and plant plastids, contributes to this dark adaptation. Levels of the stringent response alarmone guanosine 3'-diphosphate 5'-diphosphate (ppGpp) rise after a shift from light to dark, indicating that darkness triggers the same response in cyanobacteria as starvation in heterotrophic bacteria. High levels of ppGpp are sufficient to stop growth and dramatically alter many aspects of cellular physiology, including levels of photosynthetic pigments and polyphosphate, DNA content, and the rate of translation. Cells unable to synthesize ppGpp display pronounced growth defects after exposure to darkness. The stringent response regulates expression of a number of genes in Synechococcus, including ribosomal hibernation promoting factor (hpf), which causes ribosomes to dimerize in the dark and may contribute to decreased translation. Although the metabolism of Synechococcus differentiates it from other model bacterial systems, the logic of the stringent response remains remarkably conserved, while at the same time having adapted to the unique stresses of the photosynthetic lifestyle.

  19. Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

    DEFF Research Database (Denmark)

    Kristensen, Ole; Laurberg, Martin; Liljas, Anders

    2004-01-01

    Exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GPPA) enzymes play central roles in the bacterial stringent response induced by starvation. The high-resolution crystal structure of the putative Aquifex aeolicus PPX/GPPA phosphatase from the actin-like ATPase domain superfamily h...

  20. Explosive signatures: Pre & post blast

    Science.gov (United States)

    Bernier, Evan Thomas

    Manuscripts 1 and 2 of this dissertation both involve the pre-blast detection of trace explosive material. The first manuscript explores the analysis of human hair as an indicator of exposure to explosives. Field analysis of hair for trace explosives is quick and non-invasive, and could prove to be a powerful linkage to physical evidence in the form of bulk explosive material. Individuals tested were involved in studies which required handling or close proximity to bulk high explosives such as TNT, PETN, and RDX. The second manuscript reports the results of research in the design and application of canine training aids for non-traditional, peroxide-based explosives. Organic peroxides such as triacetonetriperoxide (TATP) and hexamethylenetriperoxidediamine (HMTD) can be synthesized relatively easily with store-bought ingredients and have become popular improvised explosives with many terrorist groups. Due to the hazards of handling such sensitive compounds, this research established methods for preparing training aids which contained safe quantities of TATP and HMTD for use in imprinting canines with their characteristic odor. Manuscripts 3 and 4 of this dissertation focus on research conducted to characterize pipe bombs during and after an explosion (post-blast). Pipe bombs represent a large percentage of domestic devices encountered by law enforcement. The current project has involved the preparation and controlled explosion of over 90 pipe bombs of different configurations in order to obtain data on fragmentation patterns, fragment velocity, blast overpressure, and fragmentation distance. Physical data recorded from the collected fragments, such as mass, size, and thickness, was correlated with the relative power of the initial device. Manuscript 4 explores the microstructural analysis of select pipe bomb fragments. Shock-loading of the pipe steel led to plastic deformation and work hardening in the steel grain structure as evidenced by optical microscopy and

  1. Recent Results from BLAST

    International Nuclear Information System (INIS)

    Hasell, D.K.

    2005-01-01

    The Bates Large Acceptance Spectrometer Toroid experiment, BLAST, at the MIT-Bates Linear Accelerator Laboratory is designed to study in a systematic manner the spindependent electromagnetic interaction in few-nucleon systems at momentum transfers below 1 GeV/c. Utilizing a polarized electron beam, highly polarized internal gas targets of H and D, and a symmetric detector configuration, BLAST is able to make simultaneous measurements of several reaction channels for different combinations of beam helicity and target polarization (vector for H, both vector and tensor for D). BLAST will provide new data on the nucleon and deuteron form factors as well as study few body physics and pion production. Preliminary results are presented

  2. Environmental problems associated with blasting in mines: public apprehensions of damage due to blast vibrations - case studies

    Energy Technology Data Exchange (ETDEWEB)

    Padhi, S.N. [DGMS, Bhubaneswar (India)

    1994-12-31

    Blast vibrations may be felt in intensities as small as 1/100 of that required to cause any damage to structures. Therefore, the public response and thus complaints regarding damages are often imaginary. The paper deals with three case studies, involving alleged damage from blasting in surface and underground coal mines where public litigations and agitations resulted due to such apprehensions. The paper is written in simple technical language as the situations warranted that the blast vibration studies should be understood by the general public. 7 tabs.

  3. Determination of Destress Blasting Effectiveness Using Seismic Source Parameters

    Science.gov (United States)

    Wojtecki, Łukasz; Mendecki, Maciej J.; Zuberek, Wacaław M.

    2017-12-01

    Underground mining of coal seams in the Upper Silesian Coal Basin is currently performed under difficult geological and mining conditions. The mining depth, dislocations (faults and folds) and mining remnants are responsible for rockburst hazard in the highest degree. This hazard can be minimized by using active rockburst prevention, where destress blastings play an important role. Destress blastings in coal seams aim to destress the local stress concentrations. These blastings are usually performed from the longwall face to decrease the stress level ahead of the longwall. An accurate estimation of active rockburst prevention effectiveness is important during mining under disadvantageous geological and mining conditions, which affect the risk of rockburst. Seismic source parameters characterize the focus of tremor, which may be useful in estimating the destress blasting effects. Investigated destress blastings were performed in coal seam no. 507 during its longwall mining in one of the coal mines in the Upper Silesian Coal Basin under difficult geological and mining conditions. The seismic source parameters of the provoked tremors were calculated. The presented preliminary investigations enable a rapid estimation of the destress blasting effectiveness using seismic source parameters, but further analysis in other geological and mining conditions with other blasting parameters is required.

  4. Blast Load Simulator Experiments for Computational Model Validation Report 3

    Science.gov (United States)

    2017-07-01

    establish confidence in the simulation results specific to their intended use. One method for providing experimental data for computational model...walls, to higher blast pressures required to evaluate the performance of protective construction methods . Figure 1. ERDC Blast Load Simulator (BLS... Instrumentation included 3 pressure gauges mounted on the steel calibration plate, 2 pressure gauges mounted in the wall of the BLS, and 25 pressure gauges

  5. Test methods for protective footwear against AP mine blast

    OpenAIRE

    Cronin, D.S.; Williams, K.; Bass, C.R.; Magnan, P.; Dosquet, F.; Bergeron, D.M.; Bree, J.L.M.J. van

    2003-01-01

    The testing and development of protective footwear for anti-personnel landmine blast threats is of great importance to civilian and military deminers, and peacekeepers. This study will review the wide range of test methods that have been developed by NATO countries to test footwear against the effects of anti-personnel blast mines. Experimental testing requires the definition of a threat and a means of assessing the expected trauma to the human leg. The latter is accomplished with various phy...

  6. Expanded rock blast modeling capabilities of DMC{_}BLAST, including buffer blasting

    Energy Technology Data Exchange (ETDEWEB)

    Preece, D.S. [Sandia National Labs., Albuquerque, NM (United States); Tidman, J.P.; Chung, S.H. [ICI Explosives (Canada)

    1996-12-31

    A discrete element computer program named DMC{_}BLAST (Distinct Motion Code) has been under development since 1987 for modeling rock blasting. This program employs explicit time integration and uses spherical or cylindrical elements that are represented as circles in 2-D. DMC{_}BLAST calculations compare favorably with data from actual bench blasts. The blast modeling capabilities of DMC{_}BLAST have been expanded to include independently dipping geologic layers, top surface, bottom surface and pit floor. The pit can also now be defined using coordinates based on the toe of the bench. A method for modeling decked explosives has been developed which allows accurate treatment of the inert materials (stemming) in the explosive column and approximate treatment of different explosives in the same blasthole. A DMC{_}BLAST user can specify decking through a specific geologic layer with either inert material or a different explosive. Another new feature of DMC{_}BLAST is specification of an uplift angle which is the angle between the normal to the blasthole and a vector defining the direction of explosive loading on particles adjacent to the blasthole. A buffer (choke) blast capability has been added for situations where previously blasted material is adjacent to the free face of the bench preventing any significant lateral motion during the blast.

  7. Blasting agents and initiation systems

    Energy Technology Data Exchange (ETDEWEB)

    Fiscor, S.

    2000-01-01

    Although blasting differs between and within each industry, as a whole, the mines and quarries are making a shift from a purely ammonium nitrate/fuel oil (ANFO) mixture to a blend of emulsion and ANFO on a straight emulsion. Non-electric (shock tube) initiation systems have provided a viable alternative to the electric detonator (blasting cap). Explosives manufacturers are seeing their roles changes to being blasting contractors or consultants rather than just suppliers. The article discusses these trends and gives examples of typical blasting techniques and amounts of blasting agent used at large USA surface coal mines. Electric caps are still used in blasting underground coal. The Ensign Bickford Co. (EBCo) is developing electronic detonators and has been field testing an electronic initiator, the DIGIDET detonator, for the last four years. When commercially available, electronic detonators will be accurate but will come with a hefty price tag. 2 photos.

  8. The Stringent Response Induced by Phosphate Limitation Promotes Purine Salvage in Agrobacterium fabrum.

    Science.gov (United States)

    Sivapragasam, Smitha; Deochand, Dinesh K; Meariman, Jacob K; Grove, Anne

    2017-10-31

    Agrobacterium fabrum induces tumor growth in susceptible plant species. The upregulation of virulence genes that occurs when the bacterium senses plant-derived compounds is enhanced by acidic pH and limiting inorganic phosphate. Nutrient starvation may also trigger the stringent response, and purine salvage is among the pathways expected to be favored under such conditions. We show here that phosphate limitation induces the stringent response, as evidenced by production of (p)ppGpp, and that the xdhCSML operon encoding the purine salvage enzyme xanthine dehydrogenase is upregulated ∼15-fold. The xdhCSML operon is under control of the TetR family transcription factor XdhR; direct binding of ppGpp to XdhR attenuates DNA binding, and the enhanced xdhCSML expression correlates with increased cellular levels of (p)ppGpp. Xanthine dehydrogenase may also divert purines away from salvage pathways to form urate, the ligand for the transcription factor PecS, which in the plant pathogen Dickeya dadantii is a key regulator of virulence gene expression. However, urate levels remain low under conditions that produce increased levels of xdhCSML expression, and neither acidic pH nor limiting phosphate results in induction of genes under control of PecS. Instead, expression of such genes is induced only by externally supplemented urate. Taken together, our data indicate that purine salvage is favored during the stringent response induced by phosphate starvation, suggesting that control of this pathway may constitute a novel approach to modulating virulence. Because bacterial purine catabolism appears to be unaffected, as evidenced by the absence of urate accumulation, we further propose that the PecS regulon is induced by only host-derived urate.

  9. prfectBLAST: a platform-independent portable front end for the command terminal BLAST+ stand-alone suite.

    Science.gov (United States)

    Santiago-Sotelo, Perfecto; Ramirez-Prado, Jorge Humberto

    2012-11-01

    prfectBLAST is a multiplatform graphical user interface (GUI) for the stand-alone BLAST+ suite of applications. It allows researchers to do nucleotide or amino acid sequence similarity searches against public (or user-customized) databases that are locally stored. It does not require any dependencies or installation and can be used from a portable flash drive. prfectBLAST is implemented in Java version 6 (SUN) and runs on all platforms that support Java and for which National Center for Biotechnology Information has made available stand-alone BLAST executables, including MS Windows, Mac OS X, and Linux. It is free and open source software, made available under the GNU General Public License version 3 (GPLv3) and can be downloaded at www.cicy.mx/sitios/jramirez or http://code.google.com/p/prfectblast/.

  10. Nuclear blast and fall-out shelter

    International Nuclear Information System (INIS)

    Daroga, N.D.

    1984-01-01

    A nuclear blast and fall-out shelter is described with automatically controlled oxygen supply means, air reconditioning means to remove CO and CO 2 , a hand operated pump for introducing external air if required, an over-pressure outlet valve, and means for automatically measuring the proportion of CO and CO 2 in the air in the shelter and giving an alarm signal in case of danger. (author)

  11. BlaSTorage: a fast package to parse, manage and store BLAST results.

    Science.gov (United States)

    Orsini, Massimiliano; Carcangiu, Simone

    2013-01-30

    Large-scale sequence studies requiring BLAST-based analysis produce huge amounts of data to be parsed. BLAST parsers are available, but they are often missing some important features, such as keeping all information from the raw BLAST output, allowing direct access to single results, and performing logical operations over them. We implemented BlaSTorage, a Python package that parses multi BLAST results and returns them in a purpose-built object-database format. Unlike other BLAST parsers, BlaSTorage retains and stores all parts of BLAST results, including alignments, without loss of information; a complete API allows access to all the data components. BlaSTorage shows comparable speed of more basic parser written in compiled languages as C++ and can be easily integrated into web applications or software pipelines.

  12. BlaSTorage: a fast package to parse, manage and store BLAST results

    Directory of Open Access Journals (Sweden)

    Orsini Massimiliano

    2013-01-01

    Full Text Available Abstract Background Large-scale sequence studies requiring BLAST-based analysis produce huge amounts of data to be parsed. BLAST parsers are available, but they are often missing some important features, such as keeping all information from the raw BLAST output, allowing direct access to single results, and performing logical operations over them. Findings We implemented BlaSTorage, a Python package that parses multi BLAST results and returns them in a purpose-built object-database format. Unlike other BLAST parsers, BlaSTorage retains and stores all parts of BLAST results, including alignments, without loss of information; a complete API allows access to all the data components. Conclusions BlaSTorage shows comparable speed of more basic parser written in compiled languages as C++ and can be easily integrated into web applications or software pipelines.

  13. BeoBLAST: distributed BLAST and PSI-BLAST on a Beowulf cluster.

    Science.gov (United States)

    Grant, J D; Dunbrack, R L; Manion, F J; Ochs, M F

    2002-05-01

    BeoBLAST is an integrated software package that handles user requests and distributes BLAST and PSI-BLAST searches to nodes of a Beowulf cluster, thus providing a simple way to implement a scalable BLAST system on top of relatively inexpensive computer clusters. Additionally, BeoBLAST offers a number of novel search features through its web interface, including the ability to perform simultaneous searches of multiple databases with multiple queries, and the ability to start a search using the PSSM generated from a previous PSI-BLAST search on a different database. The underlying system can also handle automated querying for high throughput work. Source code is available under the GNU public license at http://bioinformatics.fccc.edu/

  14. Tunnel blasting - recent developments

    Energy Technology Data Exchange (ETDEWEB)

    White, T.E.

    1999-05-01

    While tunnelling machines are more efficient than previously, there are still areas where blasting is a more efficient method of advance. Drilling and design methods are increasingly sophisticated, as is choice of explosive. Explosive deployment must be carefully calculated so as to avoid desensitisation. Nitroglycerine may be used as slurries; bulk mixing on site of ANFO is also practised in mining in the UK. Electric detonators, Nonel tubes, and electronic detonators are also increasingly employed.

  15. Investigations of primary blast-induced traumatic brain injury

    Science.gov (United States)

    Sawyer, T. W.; Josey, T.; Wang, Y.; Villanueva, M.; Ritzel, D. V.; Nelson, P.; Lee, J. J.

    2018-01-01

    The development of an advanced blast simulator (ABS) has enabled the reproducible generation of single-pulse shock waves that simulate free-field blast with high fidelity. Studies with rodents in the ABS demonstrated the necessity of head restraint during head-only exposures. When the head was not restrained, violent global head motion was induced by pressures that would not produce similar movement of a target the size and mass of a human head. This scaling artefact produced changes in brain function that were reminiscent of traumatic brain injury (TBI) due to impact-acceleration effects. Restraint of the rodent head eliminated these, but still produced subtle changes in brain biochemistry, showing that blast-induced pressure waves do cause brain deficits. Further experiments were carried out with rat brain cell aggregate cultures that enabled the conduct of studies without the gross movement encountered when using rodents. The suspension nature of this model was also exploited to minimize the boundary effects that complicate the interpretation of primary blast studies using surface cultures. Using this system, brain tissue was found not only to be sensitive to pressure changes, but also able to discriminate between the highly defined single-pulse shock waves produced by underwater blast and the complex pressure history exposures experienced by aggregates encased within a sphere and subjected to simulated air blast. The nature of blast-induced primary TBI requires a multidisciplinary research approach that addresses the fidelity of the blast insult, its accurate measurement and characterization, as well as the limitations of the biological models used.

  16. High productivity vacuum blasting system

    International Nuclear Information System (INIS)

    Ebadian, M.A.

    2000-01-01

    The purpose of the project is to increase the productivity and economics of existing vacuum blasting technology. This technology is used to remove radioactive contamination, PCB's and lead-base paint and provides worker and environmental protection by continuously recycling the blast media and the full containment of the dust generated in the process

  17. Full-scale testing of leakage of blast waves inside a partially vented room exposed to external air blast loading

    Science.gov (United States)

    Codina, R.; Ambrosini, D.

    2018-03-01

    For the last few decades, the effects of blast loading on structures have been studied by many researchers around the world. Explosions can be caused by events such as industrial accidents, military conflicts or terrorist attacks. Urban centers have been prone to various threats including car bombs, suicide attacks, and improvised explosive devices. Partially vented constructions subjected to external blast loading represent an important topic in protective engineering. The assessment of blast survivability inside structures and the development of design provisions with respect to internal elements require the study of the propagation and leakage of blast waves inside buildings. In this paper, full-scale tests are performed to study the effects of the leakage of blast waves inside a partially vented room that is subjected to different external blast loadings. The results obtained may be useful for proving the validity of different methods of calculation, both empirical and numerical. Moreover, the experimental results are compared with those computed using the empirical curves of the US Defense report/manual UFC 3-340. Finally, results of the dynamic response of the front masonry wall are presented in terms of accelerations and an iso-damage diagram.

  18. PREVALENCE OF RICE BLAST AND VARIETAL

    African Journals Online (AJOL)

    search-screening site grown to an improved vari- ety, Tox 3050, was heavily blasted. There was no blast incidence at Damongo. in Upper East. Region, there was severe incidence of blast in farmers' fields at Bawku and PVS nurseries and farmers' fields at Nyorigu. There was no blast at. Manga, Navrongo, Tono, Sandema, ...

  19. Computational modeling of blast induced whole-body injury: a review.

    Science.gov (United States)

    Chanda, Arnab; Callaway, Christian

    2018-02-01

    Blast injuries affect millions of lives across the globe due to its traumatic after effects on the brain and the whole body. To date, military grade armour materials are designed to mitigate ballistic and shrapnel attacks but are less effective in resisting blast impacts. In order to improve blast absorption characteristics of armours, the first key step is thoroughly understands the effects of blasts on the human body itself. In the last decade, a plethora of experimental and computational work has been carried out to investigate the mechanics and pathophysiology of Traumatic Brain Injury (TBI). However, very few attempts have been made so far to study the effect of blasts on the various other parts of the body such as the sensory organs (eyes and ears), nervous system, thorax, extremities, internal organs (such as the lungs) and the skeletal system. While an experimental evaluation of blast effects on such physiological systems is difficult, developing finite element (FE) models could allow the recreation of realistic blast scenarios on full scale human models and simulate the effects. The current article reviews the state-of-the-art in computational research in blast induced whole-body injury modelling, which would not only help in identifying the areas in which further research is required, but would also be indispensable for understanding body location specific armour design criteria for improved blast injury mitigation.

  20. Dual Regulation of Bacillus subtilis kinB Gene Encoding a Sporulation Trigger by SinR through Transcription Repression and Positive Stringent Transcription Control

    Directory of Open Access Journals (Sweden)

    Yasutaro Fujita

    2017-12-01

    Full Text Available It is known that transcription of kinB encoding a trigger for Bacillus subtilis sporulation is under repression by SinR, a master repressor of biofilm formation, and under positive stringent transcription control depending on the adenine species at the transcription initiation nucleotide (nt. Deletion and base substitution analyses of the kinB promoter (PkinB region using lacZ fusions indicated that either a 5-nt deletion (Δ5, nt -61/-57, +1 is the transcription initiation nt or the substitution of G at nt -45 with A (G-45A relieved kinB repression. Thus, we found a pair of SinR-binding consensus sequences (GTTCTYT; Y is T or C in an inverted orientation (SinR-1 between nt -57/-42, which is most likely a SinR-binding site for kinB repression. This relief from SinR repression likely requires SinI, an antagonist of SinR. Surprisingly, we found that SinR is essential for positive stringent transcription control of PkinB. Electrophoretic mobility shift assay (EMSA analysis indicated that SinR bound not only to SinR-1 but also to SinR-2 (nt -29/-8 consisting of another pair of SinR consensus sequences in a tandem repeat arrangement; the two sequences partially overlap the ‘-35’ and ‘-10’ regions of PkinB. Introduction of base substitutions (T-27C C-26T in the upstream consensus sequence of SinR-2 affected positive stringent transcription control of PkinB, suggesting that SinR binding to SinR-2 likely causes this positive control. EMSA also implied that RNA polymerase and SinR are possibly bound together to SinR-2 to form a transcription initiation complex for kinB transcription. Thus, it was suggested in this work that derepression of kinB from SinR repression by SinI induced by Spo0A∼P and occurrence of SinR-dependent positive stringent transcription control of kinB might induce effective sporulation cooperatively, implying an intimate interplay by stringent response, sporulation, and biofilm formation.

  1. HIGH PRODUCTIVITY VACUUM BLASTING SYSTEM

    International Nuclear Information System (INIS)

    McPhee, William S.

    1999-01-01

    The objective of this project is to improve the productivity and lower the expense of existing vacuum blasting technology. This technology is used to remove radioactive contamination, PCBs, and lead-based paint and provides worker protection by continuously recycling the material and dust for the decontamination tasks. The proposed work would increase the cleaning rate and provide safe and cost-effective decontamination of the DOE sites. This work focuses on redesigning and improving existing vacuum blasting technology including blast head nozzles, ergonomic handling of the blast head by reducing its weight; brush-ring design, vacuum level regulator, efficiency of the dust separator, and operational control sensors. The redesign is expected to enhance the productivity and economy of the vacuum blasting system by at least 50% over current vacuum blasting systems. There are three phases in the project. Phase I consists of developing and testing mathematical models. Phase II consists of pre-prototype design and fabrication and pre-prototype unit testing. Phase III consists of prototype design and field verification testing. In phase I, mathematical models are developed and analyzed for the nozzle, blast head, wind curtain, and dust separator, first as individual devices and then combined as an integrated model. This allows study of respective airflow and design parameters. The Contractor shall, based on the results of the mathematical modeling studies, design experimental models of the components and test these models. In addition, the Contractor shall develop sensors to detect the relationship of the blast head to the blast surfaces and controls to minimize the dependency on an operator's skill and judgment to obtain optimum positioning, as well as real-time characterization sensors to determine as the blast head is moving the depth to which coatings must be removed, thereby improving production and minimizing waste. In phase II, the Contractor shall design and

  2. BOMB BLAST: PATTERN AND NATURE OF INJURIES

    OpenAIRE

    Brahmaji Master; Chandra Sekhar; Rangaiah

    2015-01-01

    Bomb blast cause injury on large groups of people by multiple mechanisms. Bomb blast injuries differ from the conventional description of trauma complexity. Primary injuries are caused by blast wave and over pressure. Secondary injuries are caused by flyin g debris and cause shrapnel wounds. Tertiary injuries are caused by blast wind due to forceful impact and quaternary injuries are caused by other vectors like heat, radiation etc. Combined injuries, especially blast and...

  3. D-BLAST OFDM with Channel Estimation

    Directory of Open Access Journals (Sweden)

    Du Jianxuan

    2004-01-01

    Full Text Available Multiple-input and multiple-output (MIMO systems formed by multiple transmit and receive antennas can improve performance and increase capacity of wireless communication systems. Diagonal Bell Laboratories Layered Space-Time (D-BLAST structure offers a low-complexity solution for realizing the attractive capacity of MIMO systems. However, for broadband wireless communications, channel is frequency-selective and orthogonal frequency division multiplexing (OFDM has to be used with MIMO techniques to reduce system complexity. In this paper, we investigate D-BLAST for MIMO-OFDM systems. We develop a layerwise channel estimation algorithm which is robust to channel variation by exploiting the characteristic of the D-BLAST structure. Further improvement is made by subspace tracking to considerably reduce the error floor. Simulation results show that the layerwise estimators require 1 dB less signal-to-noise ratio (SNR than the traditional blockwise estimator for a word error rate (WER of when Doppler frequency is 40 Hz. Among the layerwise estimators, the subspace-tracking estimator provides a 0.8 dB gain for WER with 200 Hz Doppler frequency compared with the DFT-based estimator.

  4. Air-injected slurry blasting tests

    International Nuclear Information System (INIS)

    Wood, C.R.

    1983-01-01

    The Defense Waste Processing Facility (DWPF) will immobilize SRP high-level liquid waste in a borosilicate glass form. The molten waste glass at about 1050 0 C is poured into large (2-ft-dia, 10-ft-long) stainless steel canisters. During this operation the exterior of the canister reaches a temperature of up to 550 0 C and a thin oxide film is formed. This film traps radionuclide particles and must be removed to achieve the decontamination required before the canister leaves the DWPF canyon building. Air-injected frit slurry blasting has been chosen as the DWPF canister decontamination process based on results of tests with radioactively contaminated coupons. A small frit blaster in the Equipment Test Facility (ETF) has been used to optimize this process. Stainless steel coupons were heated at 600 0 C for 1 hour to simulate the canister oxide film. The coupons were weighed and then blasted at different parametric conditions. By weighing the coupons after blasting, the effects produced by each parameter could be compared and optimum parametric values determined

  5. Controlled Blasting for Deconstruction of a Railway Bridge Near Sahibganj

    Science.gov (United States)

    Mandal, S. K.; Ghosh, A. K.; Oraon, S.

    2018-02-01

    Some of the Indian Railway bridges require reconstruction for electrification and expansion of railway tracks. Dismantling of bridge within time schedule in densely populated area requires controlled and pre-planned blasting methodology for safe pulling down of the structure and quick removal of blasted debris for fast restoration of tracks and smooth plying of trains. The three arched railway bridge (Bridge No. 61) located between Sahibganj and Karamtola cases one such example where the bridge was dismantled and the track was restored within 4 h of blasting, though the stipulated block period for demolition and restoration of tracks was 6 h. The 25.48 m long three-arched bridge was drilled and blasted with 225 number of blastholes (32 mm diameter) and 100 kg explosive (25 mm diameter). Length of blastholes varied between 0.5 and 1.8 m with blast geometry of 0.3-0.35 m burden and 0.33 m spacing. This paper deals with the conceptual and theoretical model developed for identification of the key locations for drilling and implementation of the same. It also discusses about the precautionary measures and the drilling pattern adopted for quick demolition and speedy restoration of tracks.

  6. Civilian blast-related burn injuries.

    Science.gov (United States)

    Patel, J N; Tan, A; Dziewulski, P

    2016-03-31

    There is limited English literature describing the experience of a civilian hospital managing blast-related burn injuries. As the largest regional burn unit, we reviewed our cases with the aim of identifying means to improve current management. A 6-year retrospective analysis of all patients coded as sustaining blast-related burns was conducted through the unit's burns database. Medical case notes were reviewed for information on burn demographics, management and outcomes. 42 patients were identified. Male to female ratio was 37:5. Age range was 12-84 years, (mean=33 years). Total body surface area (%TBSA) burn ranged from 0.25% to 60%, (median=1%). The most common burn injury was flame (31/42, 73.8%). Gas explosions were the most common mechanism of injury (19 cases; 45.2%). 7/42 cases (16.7%) had full ATLS management pre-transfer to the burns unit. The Injury Severity Score (ISS) ranged from 0-43 (median=2). 17/42 (40.4%) patients required admission. 37/36 (88.1%) patients were managed conservatively of which 1 patient later required surgery due to deeper burns. 5/42 (11.9%) patients required surgical management at presentation and these were noted to be burns with >15% TBSA requiring resuscitation. One case required emergency escharotomies and finger amputations. All patients survived their burn injuries. Blast-related burn injuries are generally uncommon in the civilian setting. Following proper assessment, most of these cases can be deemed as minor injuries and managed conservatively. Improvement in burns management education and training at local emergency departments would provide efficient patient care and avoid unnecessary referrals to a burns unit.

  7. CO2 pellet blasting studies

    International Nuclear Information System (INIS)

    Archibald, K.E.

    1997-01-01

    Initial tests with CO 2 pellet blasting as a decontamination technique were completed in 1993 at the Idaho Chemical Processing Plant (ICPP) at the Idaho National Engineering Laboratory (INEL). During 1996, a number of additional CO 2 pellet blasting studies with Alpheus Cleaning Technologies, Oak Ridge National Laboratory, and Pennsylvania State University were conducted. After the testing with Alpheus was complete, an SDI-5 shaved CO 2 blasting unit was purchased by the ICPP to test and determine its capabilities before using in ICPP decontamination efforts. Results of the 1996 testing will be presented in this report

  8. Air Quality and Health Benefits of China's Recent Stringent Environmental Policy

    Science.gov (United States)

    Zheng, Y.; Xue, T.; Zhang, Q.; Geng, G.; He, K.

    2016-12-01

    Aggressive emission control measures were taken by China's central and local governments after the promulgation of the "Air Pollution Prevention and Control Action Plan" in 2013. We evaluated the air quality and health benefits of this ever most stringent air pollution control policy during 2013-2015 by utilizing a two-stage data fusion model and newly-developed cause-specific integrated exposure-response functions (IER) developed for the Global Burden of Disease (GBD). The two-stage data fusion model predicts spatiotemporal continuous PM2.5 (particulate matter with aerodynamic diameter less than 2.5 µm) concentrations by integrating satellite-derived aerosol optical depth (AOD) measurements, PM2.5 concentrations from measurement and air quality model, and other ancillary information. During the years of analysis, PM2.5 concentration dropped significantly on national average and over heavily polluted regions as identified by Mann-Kendall analysis. The national PM2.5-attributable mortality decreased by 72.8 (95% CI: 59.4, 85.2) thousand (6%) from 1.23 (95% CI: 1.06, 1.39) million in 2013 to 1.15 (95% CI: 0.98, 1.31) million in 2015 due to considerable reduction (i.e. 18%) of population-weighted PM2.5 from 61.4 to 50.5 µg/m3. Meteorological variations between 2013 and 2015 were estimated to raise the PM2.5 levels by 0.24 µg/m3 and national mortality by 2.1 (95% CI: 1.6, 2.6) thousand through sensitivity tests, which implies the dominant role of anthropogenic impacts on PM2.5 abatement and attributable mortality reduction. Our study affirms the effectiveness of China's recent air quality policy, however, due to the possible supralinear shape of C-R functions, health benefits induced by air quality improvement in these years are limited. We therefore appeal for continuous implementation of current policies and further stringent measures from both air quality improvement and public health protection perspectives.

  9. Does dishonesty really invite third-party punishment? Results of a more stringent test.

    Science.gov (United States)

    Konishi, Naoki; Ohtsubo, Yohsuke

    2015-05-01

    Many experiments have demonstrated that people are willing to incur cost to punish norm violators even when they are not directly harmed by the violation. Such altruistic third-party punishment is often considered an evolutionary underpinning of large-scale human cooperation. However, some scholars argue that previously demonstrated altruistic third-party punishment against fairness-norm violations may be an experimental artefact. For example, envy-driven retaliatory behaviour (i.e. spite) towards better-off unfair game players may be misidentified as altruistic punishment. Indeed, a recent experiment demonstrated that participants ceased to inflict third-party punishment against an unfair player once a series of key methodological problems were systematically controlled for. Noticing that a previous finding regarding apparently altruistic third-party punishment against honesty-norm violations may have been subject to methodological issues, we used a different and what we consider to be a more sound design to evaluate these findings. Third-party punishment against dishonest players withstood this more stringent test. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  10. Emission reductions in transition economies: A result of output contraction or more stringent environmental policy?

    Energy Technology Data Exchange (ETDEWEB)

    Zugravu, N.; Millock, K. [University Paris 1 Pantheon-Sorbonne (France); Duchene, G. [University Paris 12, Creteil (France)

    2007-07-01

    Countries in Central and Eastern Europe significantly reduced their CO{sub 2} emissions between 1996 and 2001. Was this emission reduction just the fortuitous result of the major economic transformation undergone by those countries in the transition away from a centralized plan economy? Or is the emission reduction rather a result of more stringent environmental policy? The objective of the article is to answer this question through a model of the relation between environmental quality and enforcement, on the one hand, and environmental quality and economic growth, on the other hand. The authors develop structural equations for the demand (emissions) and supply (environmental stringency) of pollution. The supply equation takes into account the institutional quality of the country (control of corruption and political stability) as well as consumer preferences for environmental quality, as proxied by per capita revenue and unemployment. The system is estimated by three stage least squares on a sample of three groups of countries for comparative analysis: Central and Eastern European countries, Western European countries, and emerging economies. The results indicate that, all else equal, the scale effect on its own would have increased industrial CO{sub 2} emissions in the Central and Eastern European countries in the sample by 44.6% between 1996 and 2001. The composition effect accounted for a corresponding reduction in emissions by 16%. The technique effect had the largest marginal impact, corresponding to a 37.4% reduction in emissions.

  11. Bulk development and stringent selection of microsatellite markers in the western flower thrips Frankliniella occidentalis.

    Science.gov (United States)

    Cao, Li-Jun; Li, Ze-Min; Wang, Ze-Hua; Zhu, Liang; Gong, Ya-Jun; Chen, Min; Wei, Shu-Jun

    2016-05-20

    Recent improvements in next-generation sequencing technologies have enabled investigation of microsatellites on a genome-wide scale. Faced with a huge amount of candidates, the use of appropriate marker selection criteria is crucial. Here, we used the western flower thrips Frankliniella occidentalis for an empirical microsatellite survey and validation; 132,251 candidate microsatellites were identified, 92,102 of which were perfect. Dinucleotides were the most abundant category, while (AG)n was the most abundant motif. Sixty primer pairs were designed and validated in two natural populations, of which 30 loci were polymorphic, stable, and repeatable, but not all in Hardy-Weinberg equilibrium (HWE) and linkage equilibrium. Four marker panels were constructed to understand effect of marker selection on population genetic analyses: (i) only accept loci with single nucleotide insertions (SNI); (ii) only accept the most polymorphic loci (MP); (iii) only accept loci that did not deviate from HWE, did not show SNIs, and had unambiguous peaks (SS) and (iv) all developed markers (ALL). Although the MP panel resulted in microsatellites of highest genetic diversity followed by the SNI, the SS performed best in individual assignment. Our study proposes stringent criteria for selection of microsatellites from a large-scale number of genomic candidates for population genetic studies.

  12. The Stringent Response Promotes Antibiotic Resistance Dissemination by Regulating Integron Integrase Expression in Biofilms

    Directory of Open Access Journals (Sweden)

    Emilie Strugeon

    2016-08-01

    Full Text Available Class 1 integrons are genetic systems that enable bacteria to capture and express gene cassettes. These integrons, when isolated in clinical contexts, most often carry antibiotic resistance gene cassettes. They play a major role in the dissemination of antibiotic resistance among Gram-negative bacteria. The key element of integrons is the integrase, which allows gene cassettes to be acquired and shuffled. Planktonic culture experiments have shown that integrase expression is regulated by the bacterial SOS response. In natural settings, however, bacteria generally live in biofilms, which are characterized by strong antibiotic resilience and by increased expression of stress-related genes. Here, we report that under biofilm conditions, the stringent response, which is induced upon starvation, (i increases basal integrase and SOS regulon gene expression via induction of the SOS response and (ii exerts biofilm-specific regulation of the integrase via the Lon protease. This indicates that biofilm environments favor integron-mediated acquisition of antibiotic resistance and other adaptive functions encoded by gene cassettes.

  13. Explosive Blast Neuropathology and Seizures

    Directory of Open Access Journals (Sweden)

    S. Krisztian eKovacs

    2014-04-01

    Full Text Available Traumatic brain injury (TBI due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in patients who have suffered blast injuries in the Global War on Terror but the exact prevalence is unknown. The occurrence of seizures supports the contention that explosive blast leads to both cellular and structural brain pathology. Unfortunately, the exact mechanism by which explosions cause brain injury is unclear, which complicates development of meaningful therapies and mitigation strategies. To help improve understanding, detailed neuropathological analysis is needed. For this, histopathological techniques are extremely valuable and indispensable. In the following we will review the pathological results, including those from immunohistochemical and special staining approaches, from recent preclinical explosive blast studies.

  14. The BLAST experiment

    International Nuclear Information System (INIS)

    Hasell, D.; Akdogan, T.; Alarcon, R.; Bertozzi, W.; Booth, E.; Botto, T.; Calarco, J.R.; Clasie, B.; Crawford, C.; DeGrush, A.; Dow, K.; Dutta, D.; Farkhondeh, M.; Fatemi, R.; Filoti, O.; Franklin, W.; Gao, H.; Geis, E.; Gilad, S.; Hersman, W.

    2009-01-01

    The Bates large acceptance spectrometer toroid (BLAST) experiment was operated at the MIT-Bates Linear Accelerator Center from 2003 until 2005. The detector and experimental program were designed to study, in a systematic manner, the spin-dependent electromagnetic interaction in few-nucleon systems. As such the data will provide improved measurements for neutron, proton, and deuteron form factors. The data will also allow details of the reaction mechanism, such as the role of final state interactions, pion production, and resonances to be studied. The experiment used: a longitudinally polarized electron beam stored in the South Hall Storage Ring; a highly polarized, isotopically pure, internal gas target of hydrogen or deuterium provided by an atomic beam source; and a symmetric, general purpose detector based on a toroidal spectrometer with tracking, time-of-flight, Cherenkov, and neutron detectors. Details of the experiment and operation are presented.

  15. NASA TEERM Project: Corn Based Blast Media

    Science.gov (United States)

    Griffin, Chuck

    2009-01-01

    Coatings removal is a necessary part of the maintenance, repair, and overhaul activities at many NASA centers and contractor support sites. Sensitive substrates, such as composites and thin aluminum alloys require special handling such as the use of chemical stripping, pneumatic hand sanding, or softer blast media. Type V, acrylic based PMB is commonly used to de-coat, strip, or de-paint the delicate substrates of the Solid Rocket Boosters (SRBs) currently used in support of the Shuttle and slated to be used in support of CxP.

  16. Adaptation to fluctuating temperatures in an RNA virus is driven by the most stringent selective pressure.

    Directory of Open Access Journals (Sweden)

    María Arribas

    Full Text Available The frequency of change in the selective pressures is one of the main factors driving evolution. It is generally accepted that constant environments select specialist organisms whereas changing environments favour generalists. The particular outcome achieved in either case also depends on the relative strength of the selective pressures and on the fitness costs of mutations across environments. RNA viruses are characterized by their high genetic diversity, which provides fast adaptation to environmental changes and helps them evade most antiviral treatments. Therefore, the study of the adaptive possibilities of RNA viruses is highly relevant for both basic and applied research. In this study we have evolved an RNA virus, the bacteriophage Qβ, under three different temperatures that either were kept constant or alternated periodically. The populations obtained were analyzed at the phenotypic and the genotypic level to characterize the evolutionary process followed by the virus in each case and the amount of convergent genetic changes attained. Finally, we also investigated the influence of the pre-existent genetic diversity on adaptation to high temperature. The main conclusions that arise from our results are: i under periodically changing temperature conditions, evolution of bacteriophage Qβ is driven by the most stringent selective pressure, ii there is a high degree of evolutionary convergence between replicated populations and also among populations evolved at different temperatures, iii there are mutations specific of a particular condition, and iv adaptation to high temperatures in populations differing in their pre-existent genetic diversity takes place through the selection of a common set of mutations.

  17. Primary blast-induced traumatic brain injury: lessons from lithotripsy

    Science.gov (United States)

    Nakagawa, A.; Ohtani, K.; Armonda, R.; Tomita, H.; Sakuma, A.; Mugikura, S.; Takayama, K.; Kushimoto, S.; Tominaga, T.

    2017-11-01

    Traumatic injury caused by explosive or blast events is traditionally divided into four mechanisms: primary, secondary, tertiary, and quaternary blast injury. The mechanisms of blast-induced traumatic brain injury (bTBI) are biomechanically distinct and can be modeled in both in vivo and in vitro systems. The primary bTBI injury mechanism is associated with the response of brain tissue to the initial blast wave. Among the four mechanisms of bTBI, there is a remarkable lack of information regarding the mechanism of primary bTBI. On the other hand, 30 years of research on the medical application of shock waves (SWs) has given us insight into the mechanisms of tissue and cellular damage in bTBI, including both air-mediated and underwater SW sources. From a basic physics perspective, the typical blast wave consists of a lead SW followed by shock-accelerated flow. The resultant tissue injury includes several features observed in primary bTBI, such as hemorrhage, edema, pseudo-aneurysm formation, vasoconstriction, and induction of apoptosis. These are well-described pathological findings within the SW literature. Acoustic impedance mismatch, penetration of tissue by shock/bubble interaction, geometry of the skull, shear stress, tensile stress, and subsequent cavitation formation are all important factors in determining the extent of SW-induced tissue and cellular injury. In addition, neuropsychiatric aspects of blast events need to be taken into account, as evidenced by reports of comorbidity and of some similar symptoms between physical injury resulting in bTBI and the psychiatric sequelae of post-traumatic stress. Research into blast injury biophysics is important to elucidate specific pathophysiologic mechanisms of blast injury, which enable accurate differential diagnosis, as well as development of effective treatments. Herein we describe the requirements for an adequate experimental setup when investigating blast-induced tissue and cellular injury; review SW physics

  18. Blast-induced Mild Traumatic Brain Injury

    Science.gov (United States)

    2010-01-01

    directly to the brain after craniotomy 154 or 240 kPa Unknown 2.8 or 20 kPa 40 kPa 1 or 10 MPa Redistribution of phosphorylated neurofilament H...m a: 1𔃻) .... !l ~ Blast-induced Mild Traumatic Brain Injury 767 colleagues55 compared neuropsychological test results in a group of primarily...patterns between blast and non-blast-injured subjects, thus providing no support at the neuropsychological level that blast is different. However

  19. Service robot for hull-blasting

    OpenAIRE

    Ortiz Zaragoza, Francisco José; Iborra García, Andrés José; Álvarez Torres, María Bárbara; Marín García, Fulgencio; Fernández Meroño, José María

    2001-01-01

    Present grit blasting technology for hull cleaning is very pollutant, environmentally unaffordable, and it is progressively forbidden in the most environmental countries (mainly north of Europe). At the time being, the above methodology has been partially substituted by ultra highpressure water blasting, however they do not show as good performance as the grit blasting systems. This paper describes a service robot for hull blasting. The technology we developed consists of the cleanin...

  20. 30 CFR 75.1323 - Blasting circuits.

    Science.gov (United States)

    2010-07-01

    ...) Blasting circuits shall be protected from sources of stray electric current. (b) Detonators made by different manufacturers shall not be combined in the same blasting circuit. (c) Detonator leg wires shall be... used between the blasting cable and detonator circuitry shall— (1) Be undamaged; (2) Be well insulated...

  1. Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins

    Directory of Open Access Journals (Sweden)

    Dabin Ren

    2017-08-01

    Full Text Available Moraxella catarrhalis (Mcat is a prominent mucosal pathogen causing acute otitis media (AOM. We studied Mcat nasopharyngeal (NP colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP CD, oligopeptide permease (Opp A, hemagglutinin (Hag, and Pilin A clade 2 (PilA2 from stringently defined otitis prone (sOP children, who experience the greatest burden of disease, compared to non-otitis prone (NOP children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P = 0.0003 and Mcat-caused AOM rates (49 vs. 24%, P < 0.0001 than NOP children. Natural acquisition of mucosal antibodies to Mcat proteins OMP CD (IgG, P < 0.0001, OppA (IgG, P = 0.018, Hag (IgG and IgA, both P < 0.0001, and PilA2 (IgA, P < 0.0001 was lower in sOP than NOP children. Higher levels of mucosal IgG to Hag (P = 0.039 and PilA2 (P = 0.0076, and IgA to OMP CD (P = 0.010, OppA (P = 0.030, and PilA2 (P = 0.043 were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD (P = 0.0070 and Hag (P = 0.0003, and IgA to Hag (P = 0.0067 at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P < 0.0001. In conclusion, sOP children had a diminished mucosal antibody response to Mcat proteins, which was associated with higher frequencies of asymptomatic NP colonization and NP colonization progressing to Mcat-caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children.

  2. Reduction of 5in./54 Gun Blast Overpressure by Means of an Aqueous Foam- Filled Muzzle Device

    Science.gov (United States)

    1981-08-01

    Such a device is normally attached to a gun muzzle to reduce blast, but a second purpose in this testing was to obtain information about the blast...the internal pressure distribucion could be established and in- formation could be provided about the strength requirement of the device. Pres- sure

  3. Achieving stringent climate targets. An analysis of the role of transport and variable renewable energies using energy-economy-climate models

    Energy Technology Data Exchange (ETDEWEB)

    Pietzcker, Robert Carl

    2014-07-01

    Anthropogenic climate change is threatening the welfare of mankind. Accordingly, policy makers have repeatedly stated the goal of slowing climate change and limiting the increase of global mean temperature to less than 2 C above pre-industrial times (the so-called ''two degree target''). Stabilizing the temperature requires drastic reductions of greenhouse gas (GHG) emissions to nearly zero. As the global system of energy supply currently relies on fossil fuels, reducing GHG emissions can only be achieved through a full-scale transformation of the energy system. This thesis investigates the economic requirements and implications of different scenarios that achieve stringent climate mitigation targets. It starts with the analysis of characteristic decarbonization patterns and identifies two particularly relevant aspects of mitigation scenarios: deployment of variable renewable energies (VRE) and decarbonization of the transport sector. After investigating these fields in detail, we turned towards one of the most relevant questions for policy makers and analyzed the trade-off between the stringency of a climate target and its economic requirements and implications. All analyses are based on the improvement, application, comparison, and discussion of large-scale IAMs. The novel ''mitigation share'' metric allowed us to identify the relevance of specific technology groups for mitigation and to improve our understanding of the decarbonization patterns of different energy subsectors. It turned out that the power sector is decarbonized first and reaches lowest emissions, while the transport sector is slowest to decarbonize. For the power sector, non-biomass renewable energies contribute most to emission reductions, while the transport sector strongly relies on liquid fuels and therefore requires biomass in combination with carbon capture and sequestration (CCS) to reduce emissions. An in-depth investigation of the solar power

  4. Domain enhanced lookup time accelerated BLAST

    Directory of Open Access Journals (Sweden)

    Boratyn Grzegorz M

    2012-04-01

    Full Text Available Abstract Background BLAST is a commonly-used software package for comparing a query sequence to a database of known sequences; in this study, we focus on protein sequences. Position-specific-iterated BLAST (PSI-BLAST iteratively searches a protein sequence database, using the matches in round i to construct a position-specific score matrix (PSSM for searching the database in round i + 1. Biegert and Söding developed Context-sensitive BLAST (CS-BLAST, which combines information from searching the sequence database with information derived from a library of short protein profiles to achieve better homology detection than PSI-BLAST, which builds its PSSMs from scratch. Results We describe a new method, called domain enhanced lookup time accelerated BLAST (DELTA-BLAST, which searches a database of pre-constructed PSSMs before searching a protein-sequence database, to yield better homology detection. For its PSSMs, DELTA-BLAST employs a subset of NCBI’s Conserved Domain Database (CDD. On a test set derived from ASTRAL, with one round of searching, DELTA-BLAST achieves a ROC5000 of 0.270 vs. 0.116 for CS-BLAST. The performance advantage diminishes in iterated searches, but DELTA-BLAST continues to achieve better ROC scores than CS-BLAST. Conclusions DELTA-BLAST is a useful program for the detection of remote protein homologs. It is available under the “Protein BLAST” link at http://blast.ncbi.nlm.nih.gov. Reviewers This article was reviewed by Arcady Mushegian, Nick V. Grishin, and Frank Eisenhaber.

  5. Slag wool manufacturing from blast furnace slag

    Directory of Open Access Journals (Sweden)

    Володимир Петрович Руських

    2016-11-01

    Full Text Available Slag wool is the most expensive and valuable product of blast furnace slag processing. Slag wool is in great demand nowadays. The article highlights the factors influencing the mineral wool quality: chemical composition that determines the acidity of the module, the temperature of the molten slag and the required slag jet thickness consistency. Mineral wool is produced by blowing air or steam into a jet of molten slag. As a result of it the slag crushes into droplets stretching. The resulting wool contains 5% slag and 95% air. The quality of the obtained slag wool depends on the module acidity of the slag. The blast furnace slags of «Ilyich iron and steel works of Mariupol» and «Azovstal iron & steel works» are the main (short slags – they give short fibers. To obtain high-quality long fiber wool it is necessary to add admixtures into basic blast furnace slag to reduce its basicity. As a result of the fuel and energy rising prices and the necessity to reduce the slag wool cost it is necessary to develop a new technology with fiery-liquid slag, with the removal of iron compounds and sulphur from the melts and the introduction of corrective additives to improve the quality of slag wool. Good thermal conductivity (about 0,03 kcal/m∙h∙°C and other indicators (resistance, volume weight make it possible to use the materials from slag wool (pads, rigid and semi-rigid plates as heat and sound insulating materials

  6. Effect of casing yield stress on bomb blast impulse

    Directory of Open Access Journals (Sweden)

    Hutchinson M.D.

    2012-08-01

    Full Text Available An equation to predict blast effects from cased charges was first proposed by U. Fano in 1944 and revised by E.M. Fisher in 1953 [1]. Fisher’s revision provides much better matches to available blast impulse data, but still requires empirical parameter adjustments. A new derivation [2], based on the work of R.W. Gurney [3] and G.I. Taylor [4], has resulted in an equation which nearly matches experimental data. This new analytical model is also capable of being extended, through the incorporation of additional physics, such as the effects of early case fracture, finite casing thickness, casing metal strain energy dissipation, explosive gas escape through casing fractures and the comparative dynamics of blast wave and metal fragment impacts. This paper will focus on the choice of relevant case fracture strain criterion, as it will be shown that this allows the explicit inclusion of the dynamic properties of the explosive and casing metal. It will include a review and critique of the most significant earlier work on this topic, contained in a paper by Hoggatt and Recht [5]. Using this extended analytical model, good matches can readily be made to available free-field blast impulse data, without any empirical adjustments being needed. Further work will be required to apply this model to aluminised and other highly oxygen-deficient explosives.

  7. Blast wave parameters at diminished ambient pressure

    Science.gov (United States)

    Silnikov, M. V.; Chernyshov, M. V.; Mikhaylin, A. I.

    2015-04-01

    Relation between blast wave parameters resulted from a condensed high explosive (HE) charge detonation and a surrounding gas (air) pressure has been studied. Blast wave pressure and impulse differences at compression and rarefaction phases, which traditionally determine damage explosive effect, has been analyzed. An initial pressure effect on a post-explosion quasi-static component of the blast load has been investigated. The analysis is based on empirical relations between blast parameters and non-dimensional similarity criteria. The results can be directly applied to flying vehicle (aircraft or spacecraft) blast safety analysis.

  8. Parallel BLAST on split databases.

    Science.gov (United States)

    Mathog, David R

    2003-09-22

    BLAST programs often run on large SMP machines where multiple threads can work simultaneously and there is enough memory to cache the databases between program runs. A group of programs is described which allows comparable performance to be achieved with a Beowulf configuration in which no node has enough memory to cache a database but the cluster as an aggregate does. To achieve this result, databases are split into equal sized pieces and stored locally on each node. Each query is run on all nodes in parallel and the resultant BLAST output files from all nodes merged to yield the final output. Source code is available from ftp://saf.bio.caltech.edu/

  9. Control buildings for blast resistance

    Energy Technology Data Exchange (ETDEWEB)

    Brown, G.A.

    1982-08-01

    Offers advice on interior design for blast-resistant control buildings. Suggests that for the comfort and safety of occupants, special attention must be paid to internal finishes and color schemes. Considers external treatment (e.g. panels, cladding fixings, thermal insulation), air intakes and exhausts, internal finishes (e.g. stud lining method), and internal walls and partitions. Presents diagrams showing construction method for a control building; elimination of ''cold bridge'' at eaves level; staggering door openings to minimize blast effects; and flexure of concrete walls without affecting the inner lining.

  10. Blast Responses and Vibration of Flood-Defense Structures under High-Intensity Blast Loadings

    Directory of Open Access Journals (Sweden)

    Yonghee Ryu

    2018-01-01

    Full Text Available This study presented the blast behavior of flood-defense structures subjected to high-intensity loadings such as blast shock waves. In order to understand the blast behavior of weir structures, PHAST program was used to predict blast loadings in consideration of material reactivity and congestion levels. Environment factors such as weather data and atmospheric parameters were also considered in this study. Then, nonlinear dynamic analyses were performed using the ABAQUS platform to evaluate structural responses and blast vibration of concrete weir structures subjected to various types of blast loadings, due to uncertainties of the magnitude and durations of blast loads as a function of distance from the explosion. It was shown that the blast damage to concrete weir structure was significantly influenced by congestion levels or material reactivity. Also, the stress concentration under blast loading was observed at the connection area between the concrete weir body and stilling basin.

  11. Direct-to-physician and direct-to-consumer advertising: Time to have stringent regulations.

    Science.gov (United States)

    Kannan, S; Gowri, S; Tyagi, V; Kohli, S; Jain, R; Kapil, P; Bhardwaj, A

    2015-01-01

    the opinion regarding DTCA, 69.9% physicians had a patient discussing DTCA that was clinically inappropriate. One hundred (64.5%) out of 155 physicians opined that DTCA encourage patients to attend physicians regarding preventive healthcare. On the contrary, 82/155 (52.9%) physicians felt that DTCA would damage the same. Similarly, 69 out of the total 100 patients felt that drug advertisements aid them to have better discussions with their treating physicians. Surprisingly, a large majority (91/100) were of the opinion that only safe drugs are allowed to be advertised. To conclude, from the findings of this study both the physicians and patients should be cautious and not overzealous while dealing with drug advertisements or promotional literature. More stringent scrutiny and issue of WLs or blacklisting of indulging pharmaceutical companies are mandatory by the regulatory agency to contain the same.

  12. Fragment Size Distribution of Blasted Rock Mass

    Science.gov (United States)

    Jug, Jasmin; Strelec, Stjepan; Gazdek, Mario; Kavur, Boris

    2017-12-01

    Rock mass is a heterogeneous material, and the heterogeneity of rock causes sizes distribution of fragmented rocks in blasting. Prediction of blasted rock mass fragmentation has a significant role in the overall economics of opencast mines. Blasting as primary fragmentation can significantly decrease the cost of loading, transport, crushing and milling operations. Blast fragmentation chiefly depends on the specific blast design (geometry of blast holes drilling, the quantity and class of explosive, the blasting form, the timing and partition, etc.) and on the properties of the rock mass (including the uniaxial compressive strength, the rock mass elastic Young modulus, the rock discontinuity characteristics and the rock density). Prediction and processing of blasting results researchers can accomplish by a variety of existing software’s and models, one of them is the Kuz-Ram model, which is possibly the most widely used approach to estimating fragmentation from blasting. This paper shows the estimation of fragmentation using the "SB" program, which was created by the authors. Mentioned program includes the Kuz-Ram model. Models of fragmentation are confirmed and calibrated by comparing the estimated fragmentation with actual post-blast fragmentation from image processing techniques. In this study, the Kuz-Ram fragmentation model has been used for an open-pit limestone quarry in Dalmatia, southern Croatia. The resulting calibrated value of the rock factor enables the quality prognosis of fragmentation in further blasting works, with changed drilling geometry and blast design parameters. It also facilitates simulation in the program to optimize blasting works and get the desired fragmentations of the blasted rock mass.

  13. Innovative design tool for the optimization of blast-enhanced facade systems

    Directory of Open Access Journals (Sweden)

    Guido Lori

    2015-06-01

    Full Text Available In current blast enhancement design strategies, to resist the effects of an accidental explosion, a facade system is commonly designed to behave in-elastically and undergo large deformations. The large deformation of the facade system leads to high blast energy dissipation, subsequently reducing the blast energy transferred to the main structure. In addition to the blast resistance of the facade system, human injuries due to glass fragmentation within the vicinity of the facade system should also be minimized in order to meet the required safety levels. Overall building safety can be optimized by balancing blast energy dissipation and glass fragmentation. Recently, Permasteelisa Group has developed an innovative design tool to optimize blast-enhanced facades using an equivalent MDOF approach. A novel fragmentation tool has been proposed to assist this design procedure. This paper presents various critical parameters considered in blast-enhanced facade analysis, the experimental validation of these parameters and their influence in the design optimization process.  

  14. The design of system for operative planning of blast furnace production process

    Directory of Open Access Journals (Sweden)

    Malindžák Dušan

    1996-12-01

    Full Text Available A system for operative planning of blast furnace production process is described in the paper. The suggested system is based on the use of a new hierarchy of operative plans, consisting of one-month plan, (7+3 days plan, and 24-hour plan. The system allows smoothing of production process at the blast furnace plant, and at the same time satisfies all requirements of the steel plant regarding to the amount of pig iron.

  15. Mask materials for powder blasting

    NARCIS (Netherlands)

    Wensink, H.; Jansen, Henricus V.; Berenschot, Johan W.; Elwenspoek, Michael Curt

    Powder blasting, or abrasive jet machining (AJM), is a technique in which a particle jet is directed towards a target for mechanical material removal. It is a fast, cheap and accurate directional etch technique for brittle materials such as glass, silicon and ceramics. The particle jet (which

  16. INCREASED RELIABILITY OF ELECTRIC BLASTING

    OpenAIRE

    Kashuba, Oleh Ivanovych; Skliarov, L I; Skliarov, A L

    2017-01-01

    The problems of improving reliability of an electric blasting method using electric detonators with nichrome filament bridges. It was revealed that in the calculation of the total resistance of the explosive network it is necessary to increase to 24% of the nominal value

  17. Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model

    Directory of Open Access Journals (Sweden)

    Daniel Pletzer

    2017-09-01

    Full Text Available Microorganisms continuously monitor their surroundings and adaptively respond to environmental cues. One way to cope with various stress-related situations is through the activation of the stringent stress response pathway. In Pseudomonas aeruginosa this pathway is controlled and coordinated by the activity of the RelA and SpoT enzymes that metabolize the small nucleotide secondary messenger molecule (pppGpp. Intracellular ppGpp concentrations are crucial in mediating adaptive responses and virulence. Targeting this cellular stress response has recently been the focus of an alternative approach to fight antibiotic resistant bacteria. Here, we examined the role of the stringent response in the virulence of P. aeruginosa PAO1 and the Liverpool epidemic strain LESB58. A ΔrelA/ΔspoT double mutant showed decreased cytotoxicity toward human epithelial cells, exhibited reduced hemolytic activity, and caused down-regulation of the expression of the alkaline protease aprA gene in stringent response mutants grown on blood agar plates. Promoter fusions of relA or spoT to a bioluminescence reporter gene revealed that both genes were expressed during the formation of cutaneous abscesses in mice. Intriguingly, virulence was attenuated in vivo by the ΔrelA/ΔspoT double mutant, but not the relA mutant nor the ΔrelA/ΔspoT complemented with either gene. Treatment of a cutaneous P. aeruginosa PAO1 infection with anti-biofilm peptides increased animal welfare, decreased dermonecrotic lesion sizes, and reduced bacterial numbers recovered from abscesses, resembling the phenotype of the ΔrelA/ΔspoT infection. It was previously demonstrated by our lab that ppGpp could be targeted by synthetic peptides; here we demonstrated that spoT promoter activity was suppressed during cutaneous abscess formation by treatment with peptides DJK-5 and 1018, and that a peptide-treated relA complemented stringent response double mutant strain exhibited reduced peptide

  18. Study of blast wave overpressures using the computational fluid dynamics

    Directory of Open Access Journals (Sweden)

    M. L. COSTA NETO

    Full Text Available ABSTRACT The threats of bomb attacks by criminal organizations and accidental events involving chemical explosives are a danger to the people and buildings. Due the severity of these issues and the need of data required for a safety design, more research is required about explosions and shock waves. This paper presents an assessment of blast wave overpressures using a computational fluid dynamics software. Analyses of phenomena as reflection of shock waves and channeling effects were done and a comparison between numerical results and analytical predictions has been executed, based on the simulation on several models. The results suggest that the common analytical predictions aren’t accurate enough for an overpressure analysis in small stand-off distances and that poorly designed buildings may increase the shock wave overpressures due multiple blast wave reflections, increasing the destructive potential of the explosions.

  19. Alkaline carbonates in blast furnace process

    Directory of Open Access Journals (Sweden)

    P. Besta

    2014-10-01

    Full Text Available The production of iron in blast furnaces is a complex of physical, chemical and mechanical processes. The input raw materials contain not only metallic components, but also a number of negative elements. The most important negative elements include alkaline carbonates. They can significantly affect the course of the blast furnace process and thus the overall performance of the furnace. As a result of that, it is essential to accurately monitor the alkali content in the blast furnace raw materials. The article analyzes the alkali content in input and output raw materials and their impact on the blast furnace process.

  20. Temporal Progression of Visual Injury from Blast Exposure

    Science.gov (United States)

    2017-09-01

    or 48 hours) and animal orientation (side-on or face-on). Experimental evaluations using multiple species is required to fully validate the...ProQuest. Computer modeling was used to understand how the findings in our experimental animal models (and those of other researchers) can be... experimental work was performed. Several modifications to the blast device were made. In Year 3, the bulk of animal studies were completed and

  1. High-speed photography of microscale blast wave phenomena

    Science.gov (United States)

    Dewey, John M.; Kleine, Harald

    2005-03-01

    High-speed photography has been a primary tool for the study of blast wave phenomena, dating from the work of Toepler, even before the invention of the camera! High-speed photography was used extensively for the study of blast waves produced by nuclear explosions for which, because of the large scale, cameras running at a few hundred frames per second were adequate to obtain sharp images of the supersonic shock fronts. For the study of the blast waves produced by smaller explosive sources, ever-increasing framing rates were required. As a rough guide, for every three orders of magnitude decrease in charge size a ten-fold increase of framing rate was needed. This severely limited the use of photography for the study of blast waves from laboratory-scale charges. There are many techniques for taking single photographs of explosive phenomena, but the strongly time-dependent development of a blast wave, requires the ability to record a high-speed sequence of photographs of a single event. At ICHSPP25, Kondo et al of Shimadzu Corporation demonstrated a 1 M fps video camera that provides a sequence of up to 100 high-resolution frames. This was subsequently used at the Shock Wave Research Center of Tohoku University to record the blast waves generated by an extensive series of silver azide charges ranging in size from 10 to 0.5mg. The resulting images were measured to provide radius-time histories of the primary and secondary shocks. These were analyzed with techniques similar to those used for the study of explosions from charges with masses ranging from 500 kg to 5 kt. The analyses showed the cube-root scaling laws to be valid for the very small charges, and provided a detailed record of the peak hydrostatic pressure as a function of radius for a unit charge of silver azide, over a wide range of scaled distances. The pressure-radius variation was compared to that from a unit charge of TNT and this permitted a detailed determination of the TNT equivalence of silver azide

  2. HIGH PRODUCTIVITY VACUUM BLASTING SYSTEM

    International Nuclear Information System (INIS)

    McPhee, William S.

    2001-01-01

    The Department of Energy (DOE) needs improved technologies to decontaminate large areas of both concrete and steel surfaces. The technology should have high operational efficiency, minimize exposures to workers, and produce low levels of secondary waste. In order to meet the DOE's needs, an applied research and development project for the improvement of a current decontamination technology, Vacuum Blasting, is proposed. The objective of this project is to improve the productivity and lower the expense of the existing vacuum blasting technology which has been widely used in DOE sites for removing radioactive contamination, PCBs, and lead-based paint. The proposed work would increase the productivity rate and provide safe and cost-effective decontamination of the DOE sites

  3. Blasting detonators incorporating semiconductor bridge technology

    Energy Technology Data Exchange (ETDEWEB)

    Bickes, R.W. Jr.

    1994-05-01

    The enormity of the coal mine and extraction industries in Russia and the obvious need in both Russia and the US for cost savings and enhanced safety in those industries suggests that joint studies and research would be of mutual benefit. The author suggests that mine sites and well platforms in Russia offer an excellent opportunity for the testing of Sandia`s precise time-delay semiconductor bridge detonators, with the potential for commercialization of the detonators for Russian and other world markets by both US and Russian companies. Sandia`s semiconductor bridge is generating interest among the blasting, mining and perforation industries. The semiconductor bridge is approximately 100 microns long, 380 microns wide and 2 microns thick. The input energy required for semiconductor bridge ignition is one-tenth the energy required for conventional bridgewire devices. Because semiconductor bridge processing is compatible with other microcircuit processing, timing and logic circuits can be incorporated onto the chip with the bridge. These circuits can provide for the precise timing demanded for cast effecting blasting. Indeed tests by Martin Marietta and computer studies by Sandia have shown that such precise timing provides for more uniform rock fragmentation, less fly rock, reduce4d ground shock, fewer ground contaminants and less dust. Cost studies have revealed that the use of precisely timed semiconductor bridges can provide a savings of $200,000 per site per year. In addition to Russia`s vast mineral resources, the Russian Mining Institute outside Moscow has had significant programs in rock fragmentation for many years. He anticipated that collaborative studies by the Institute and Sandia`s modellers would be a valuable resource for field studies.

  4. Interspecies Scaling in Blast Neurotrauma

    Science.gov (United States)

    2015-08-27

    Armour Systems Symposium 2014 in Cambridge, England. 6.1 Introduction The increased risk of exposure to blast in both military and civilian settings...Physiological Processes in Homeothermic Animals." Annual Review of Physiology 43, 1: 301-22. Capehart, B and Bass, D. 2012. "Review: managing ...CI, Calvente, RR, Lillo, VM and Canas, JM. 2007. " Management and analysis of out-of-hospital health-related responses to simultaneous railway

  5. CO2 blasting in Europe

    International Nuclear Information System (INIS)

    Vankerckhoven, Patrick

    1995-01-01

    Carbon dioxide blasting can be used during the lifetime of nuclear facilities to remove deposited contamination and reduce the dose to personnel during repair and maintenance. By contrast with conventional mechanical or chemical decontamination methods, it does not leave additional secondary wastes. During the process, liquid CO 2 is expanded and converted into dry snow which is compressed and extruded to form small dry ice pellets. These low temperature pellets are blasted at high speed in a stream of compressed air against the surface to be treated where the mechanical and thermal shock embrittles the contaminating layer and severs its bond with the surface. The dry ice sublimes into the atmosphere as CO 2 gas and the loosened contamination can be removed via a ventilation and filtration system. Some examples of the effective use of CO 2 blasting are given. They include decontamination of: a supercompactor used on radioactive waste drums; the walls and floors of a nuclear fuel fabrication plant; the vacuum vessel of the Joint European Torus, hot cells; a phosphate fertilizer plant contaminated by radium 226. (UK)

  6. Rodent model of direct cranial blast injury.

    Science.gov (United States)

    Kuehn, Reed; Simard, Philippe F; Driscoll, Ian; Keledjian, Kaspar; Ivanova, Svetlana; Tosun, Cigdem; Williams, Alicia; Bochicchio, Grant; Gerzanich, Volodymyr; Simard, J Marc

    2011-10-01

    Traumatic brain injury resulting from an explosive blast is one of the most serious wounds suffered by warfighters, yet the effects of explosive blast overpressure directly impacting the head are poorly understood. We developed a rodent model of direct cranial blast injury (dcBI), in which a blast overpressure could be delivered exclusively to the head, precluding indirect brain injury via thoracic transmission of the blast wave. We constructed and validated a Cranium Only Blast Injury Apparatus (COBIA) to deliver blast overpressures generated by detonating .22 caliber cartridges of smokeless powder. Blast waveforms generated by COBIA replicated those recorded within armored vehicles penetrated by munitions. Lethal dcBI (LD(50) ∼ 515 kPa) was associated with: (1) apparent brainstem failure, characterized by immediate opisthotonus and apnea leading to cardiac arrest that could not be overcome by cardiopulmonary resuscitation; (2) widespread subarachnoid hemorrhages without cortical contusions or intracerebral or intraventricular hemorrhages; and (3) no pulmonary abnormalities. Sub-lethal dcBI was associated with: (1) apnea lasting up to 15 sec, with transient abnormalities in oxygen saturation; (2) very few delayed deaths; (3) subarachnoid hemorrhages, especially in the path of the blast wave; (4) abnormal immunolabeling for IgG, cleaved caspase-3, and β-amyloid precursor protein (β-APP), and staining for Fluoro-Jade C, all in deep brain regions away from the subarachnoid hemorrhages, but in the path of the blast wave; and (5) abnormalities on the accelerating Rotarod that persisted for the 1 week period of observation. We conclude that exposure of the head alone to severe explosive blast predisposes to significant neurological dysfunction.

  7. Finite Element Simulation of Medium-Range Blast Loading Using LS-DYNA

    Directory of Open Access Journals (Sweden)

    Yuzhen Han

    2015-01-01

    Full Text Available This study investigated the Finite Element simulation of blast loading using LS-DYNA. The objective is to identify approaches to reduce the requirement of computation effort while maintaining reasonable accuracy, focusing on blast loading scheme, element size, and its relationship with scale of explosion. The study made use of the recently developed blast loading scheme in LS-DYNA, which removes the necessity to model the explosive in the numerical models but still maintains the advantages of nonlinear fluid-structure interaction. It was found that the blast loading technique could significantly reduce the computation effort. It was also found that the initial density of air in the numerical model could be purposely increased to partially compensate the error induced by the use of relatively large air elements. Using the numerical approach, free air blast above a scaled distance of 0.4 m/kg1/3 was properly simulated, and the fluid-structure interaction at the same location could be properly duplicated using proper Arbitrary Lagrangian Eulerian (ALE coupling scheme. The study also showed that centrifuge technique, which has been successfully employed in model tests to investigate the blast effects, may be used when simulating the effect of medium- to large-scale explosion at small scaled distance.

  8. The use of blast furnace slag

    Directory of Open Access Journals (Sweden)

    V. Václavík

    2012-10-01

    Full Text Available The paper presents the results of experimental research that dealt with the substitution of finely ground blast furnace slag for Portland cement in the course of simple concrete manufacturing. Physical and mechanical properties of experimental concrete mixtures based on finely ground blast furnace slag were observed.

  9. Blast mitigation experimental and numerical studies

    CERN Document Server

    2013-01-01

    Presents experimental methods of material and structural response to dynamic blast loads Includes computational analysis of material and structural response to dynamic blast loads Offers mitigation measures for structures in various environments Relates lab experiments to larger field tests Features more than 150 illustrations

  10. Swift GRBs and the blast wave model

    NARCIS (Netherlands)

    Curran, P.A.; van der Horst, A.J.; Starling, R.L.C.; Wijers, R.A.M.J.

    2009-01-01

    The complex structure of the light curves of Swift GRBs has made their interpretation and that of the blast wave caused by the burst, more difficult than in the pre-Swift era. We aim to constrain the blast wave parameters: electron energy distribution, p, density profile of the circumburst medium,

  11. Measurement and Modelling of Blast Movement to Reduce Ore ...

    African Journals Online (AJOL)

    user

    with comprehensive monitoring using high speed video and blast movement markers. 2. Develop site specific models ... The Blast Movement Monitor (BMM) is a system developed and patented by the JKMRC, University .... at Ahafo mine, the current practice was to mine to pre-blast grade boundaries (from blast hole drilling.

  12. prevalence of rice blast and varietal screening in ghana

    African Journals Online (AJOL)

    search-screening site grown to an improved vari- ety, Tox 3050, was heavily blasted. There was no blast incidence at Damongo. In Upper Iiast. Region, there was severe incidence of blast in farmers' fields at Bawku and PVS nurseries and farmers' fields at Nyorigu. There was no blast at. Manga, Navrongo, Tono, Sandema, ...

  13. Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model

    Science.gov (United States)

    Goldstein, Lee E.; Fisher, Andrew M.; Tagge, Chad A.; Zhang, Xiao-Lei; Velisek, Libor; Sullivan, John A.; Upreti, Chirag; Kracht, Jonathan M.; Ericsson, Maria; Wojnarowicz, Mark W.; Goletiani, Cezar J.; Maglakelidze, Giorgi M.; Casey, Noel; Moncaster, Juliet A.; Minaeva, Olga; Moir, Robert D.; Nowinski, Christopher J.; Stern, Robert A.; Cantu, Robert C.; Geiling, James; Blusztajn, Jan K.; Wolozin, Benjamin L.; Ikezu, Tsuneya; Stein, Thor D.; Budson, Andrew E.; Kowall, Neil W.; Chargin, David; Sharon, Andre; Saman, Sudad; Hall, Garth F.; Moss, William C.; Cleveland, Robin O.; Tanzi, Rudolph E.; Stanton, Patric K.; McKee, Ann C.

    2013-01-01

    Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms, and long-term cognitive disability. We examined a case series of postmortem brains from U.S. military veterans exposed to blast and/or concussive injury. We found evidence of chronic traumatic encephalopathy (CTE), a tau protein–linked neurodegenerative disease, that was similar to the CTE neuropathology observed in young amateur American football players and a professional wrestler with histories of concussive injuries. We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL/6 mice 2 weeks after exposure to a single blast. Blast-exposed mice demonstrated phosphorylated tauopathy, myelinated axonopathy, microvasculopathy, chronic neuroinflammation, and neurodegeneration in the absence of macroscopic tissue damage or hemorrhage. Blast exposure induced persistent hippocampal-dependent learning and memory deficits that persisted for at least 1 month and correlated with impaired axonal conduction and defective activity-dependent long-term potentiation of synaptic transmission. Intracerebral pressure recordings demonstrated that shock waves traversed the mouse brain with minimal change and without thoracic contributions. Kinematic analysis revealed blast-induced head oscillation at accelerations sufficient to cause brain injury. Head immobilization during blast exposure prevented blast-induced learning and memory deficits. The contribution of blast wind to injurious head acceleration may be a primary injury mechanism leading to blast-related TBI and CTE. These results identify common pathogenic determinants leading to CTE in blast-exposed military veterans and head-injured athletes and additionally provide mechanistic evidence linking blast exposure to persistent impairments in neurophysiological function, learning, and memory. PMID:22593173

  14. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

    Science.gov (United States)

    Goldstein, Lee E; Fisher, Andrew M; Tagge, Chad A; Zhang, Xiao-Lei; Velisek, Libor; Sullivan, John A; Upreti, Chirag; Kracht, Jonathan M; Ericsson, Maria; Wojnarowicz, Mark W; Goletiani, Cezar J; Maglakelidze, Giorgi M; Casey, Noel; Moncaster, Juliet A; Minaeva, Olga; Moir, Robert D; Nowinski, Christopher J; Stern, Robert A; Cantu, Robert C; Geiling, James; Blusztajn, Jan K; Wolozin, Benjamin L; Ikezu, Tsuneya; Stein, Thor D; Budson, Andrew E; Kowall, Neil W; Chargin, David; Sharon, Andre; Saman, Sudad; Hall, Garth F; Moss, William C; Cleveland, Robin O; Tanzi, Rudolph E; Stanton, Patric K; McKee, Ann C

    2012-05-16

    Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms, and long-term cognitive disability. We examined a case series of postmortem brains from U.S. military veterans exposed to blast and/or concussive injury. We found evidence of chronic traumatic encephalopathy (CTE), a tau protein-linked neurodegenerative disease, that was similar to the CTE neuropathology observed in young amateur American football players and a professional wrestler with histories of concussive injuries. We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL/6 mice 2 weeks after exposure to a single blast. Blast-exposed mice demonstrated phosphorylated tauopathy, myelinated axonopathy, microvasculopathy, chronic neuroinflammation, and neurodegeneration in the absence of macroscopic tissue damage or hemorrhage. Blast exposure induced persistent hippocampal-dependent learning and memory deficits that persisted for at least 1 month and correlated with impaired axonal conduction and defective activity-dependent long-term potentiation of synaptic transmission. Intracerebral pressure recordings demonstrated that shock waves traversed the mouse brain with minimal change and without thoracic contributions. Kinematic analysis revealed blast-induced head oscillation at accelerations sufficient to cause brain injury. Head immobilization during blast exposure prevented blast-induced learning and memory deficits. The contribution of blast wind to injurious head acceleration may be a primary injury mechanism leading to blast-related TBI and CTE. These results identify common pathogenic determinants leading to CTE in blast-exposed military veterans and head-injured athletes and additionally provide mechanistic evidence linking blast exposure to persistent impairments in neurophysiological function, learning, and memory.

  15. The implementation of modern digital technology in x-ray medical diagnosis in Republic of Moldova - a stringent necessity

    International Nuclear Information System (INIS)

    Rosca, Andrei

    2011-01-01

    The study includes analyses of current technical state of radiodiagnostic equipment from the Public Medico-Sanitary Institution of Ministry of Health of Republic of Moldova (IMSP MS RM). The traditional radiodiagnostic apparatuses were morally and physically outrun at 96,6% (in regional MSPI - 93,5%), inclusive the dental one - 92,0% (in raional MSPI - 97,2%), X-Ray exam -100%, mobile - 84,1% etc. The exploitation of the traditional radiodiagnostic apparatuses with high degree of physical and moral wear essentially diminished the quality of profile investigation, creates premises for diagnostic error perpetrating, increase the collective ionizing irradiation of population etc. In recent years the subvention of MSPI HM RM with digital radiodiagnostic equipment was started. This process is very hard unfold because of grave socio-economic crises in Republic of Moldova. Despite these obstacles the subvention of MSPI HM RM with digital equipment represents a stringent necessity and a time request.

  16. The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

    Directory of Open Access Journals (Sweden)

    Choonkeun Kim

    Full Text Available All methicillin resistant S. aureus (MRSA strains carry an acquired genetic determinant--mecA or mecC--which encode for a low affinity penicillin binding protein -PBP2A or PBP2A'--that can continue the catalysis of peptidoglycan transpeptidation in the presence of high concentrations of beta-lactam antibiotics which would inhibit the native PBPs normally involved with the synthesis of staphylococcal cell wall peptidoglycan. In contrast to this common genetic and biochemical mechanism carried by all MRSA strains, the level of beta-lactam antibiotic resistance shows a very wide strain to strain variation, the mechanism of which has remained poorly understood. The overwhelming majority of MRSA strains produce a unique--heterogeneous--phenotype in which the great majority of the bacteria exhibit very poor resistance often close to the MIC value of susceptible S. aureus strains. However, cultures of such heterogeneously resistant MRSA strains also contain subpopulations of bacteria with extremely high beta-lactam MIC values and the resistance level and frequency of the highly resistant cells in such strain is a characteristic of the particular MRSA clone. In the study described in this communication, we used a variety of experimental models to understand the mechanism of heterogeneous beta-lactam resistance. Methicillin-susceptible S. aureus (MSSA that received the mecA determinant in the laboratory either on a plasmid or in the form of a chromosomal SCCmec cassette, generated heterogeneously resistant cultures and the highly resistant subpopulations that emerged in these models had increased levels of PBP2A and were composed of bacteria in which the stringent stress response was induced. Each of the major heterogeneously resistant clones of MRSA clinical isolates could be converted to express high level and homogeneous resistance if the growth medium contained an inducer of the stringent stress response.

  17. Global energy scenarios meeting stringent CO2 constraints - cost-effective fuel choices in the transportation sector

    International Nuclear Information System (INIS)

    Azar, Christian; Lindgren, Kristian; Andersson, B.A.

    2003-01-01

    The purpose of this paper is to assess fuel choices in the transportation sector under stringent global carbon constraints. Three key questions are asked: (i) when is it cost-effective to carry out the transition away from gasoline/diesel; (ii) to which fuel is it cost-effective to shift; and (iii) in which sector is biomass most cost-effectively used? These questions are analyzed using a global energy systems model (GET 1.0), with a transportation module, where vehicle costs (fuel cell, reformer and storage tank), infrastructure and primary energy availability are treated explicitly. The model is run under the assumption that atmospheric concentrations of CO 2 should be stabilized at 400 ppm. Three main results emerge: (i) despite the stringent CO 2 constraints, oil-based fuels remain dominant in the transportation sector over the next 50 years; and (ii) once a transition towards alternative fuels takes place, the preferred choice of fuel is hydrogen, even if we assume that hydrogen fuel cell vehicles are substantially more costly than methanol fuel cell vehicles. There may, under some circumstances, be a transient period of several decades with a significant share of methanol in the transportation sector. (iii) Biomass is most cost-effectively used in the heat and process heat sectors. If carbon sequestration from biomass is allowed, biomass is primarily used for hydrogen generation since small-scale heat applications are not suitable for carbon sequestration. Detailed sensitivity analyses show that these results are robust with respect to several parameters. Some policy conclusions are drawn

  18. Status of the BLAST experiment

    International Nuclear Information System (INIS)

    Hasell, D.K.

    2004-01-01

    The BLAST experiment is beginning operation at the MIT-Bates Linear Accelerator Laboratory. The experiment will study the spin dependent electro-magnetic interaction in few nucleon systems at momentum transfers between 0.1 and 1.0 GeV 2 . This will provide improved measurements of the nucleon form factors, particularly G E n , as well as study the structure of D and 3 He. Other reaction channels such as pion production and inclusive scattering will also be studied. The experiment, physics goals, and current status are described briefly. (orig.)

  19. Nuclear controls are stringent

    International Nuclear Information System (INIS)

    Sonnekus, D.

    1983-01-01

    The peace-time application of nuclear power in South Africa, the organisations concerned and certain provisions laid down by the Act on Nuclear Energy, aimed at safeguarding the general public, are discussed

  20. [Gunshot or blast injuries of the hand. Principles of treatment].

    Science.gov (United States)

    Kollig, E; Franke, A

    2012-07-01

    Gunshot injuries to the hand are rare in Central Europe. As a result of their special trauma morphology they are a serious threat to the functional integrity of the hand and often lead to a loss of function which can be associated with a permanent unfitness to work or disability. Blast injuries to the hand are more common in this part of the world and are usually caused by the inappropriate use of fireworks. This trauma entity is associated with a number of special kinetic features and effects which have therapeutic consequences and should therefore be discussed separately. As a result of the low incidence of these specific types of injuries in times of peace, experience-based expertise is unlikely to be available. The management of gunshot injuries to the hand is a particular challenge to hand surgeons who must have specialist knowledge and skills in order to achieve an optimum outcome. This applies even more so to the treatment of blast injuries to the hand which are associated with far more complex injury patterns. As a rule blast injuries are associated with a high risk of complications and require a rapid assessment and rigorous management of all damaged structures similar to approaches used for infections of the hand. Illustrated by several cases which have been treated at our institution the basic aspects of the development and morphology of these injuries are discussed as well as different treatment options, algorithms and possible treatment outcomes.

  1. LTC vacuum blasting machine (concrete): Baseline report

    International Nuclear Information System (INIS)

    1997-01-01

    The LTC shot blast technology was tested and is being evaluated at Florida International University (FIU) as a baseline technology. In conjunction with FIU's evaluation of efficiency and cost, this report covers the evaluation conducted for safety and health issues. It is a commercially available technology and has been used for various projects at locations throughout the country. The LTC 1073 Vacuum Blasting Machine uses a high-capacity, direct-pressure blasting system which incorporates a continuous feed for the blast media. The blast media cleans the surface within the contained brush area of the blast. It incorporates a vacuum system which removes dust and debris from the surface as it is blasted. The safety and health evaluation during the testing demonstration focused on two main areas of exposure: dust and noise. Dust exposure during maintenance activities was minimal, but due to mechanical difficulties dust monitoring could not be conducted during operation. Noise exposure was significant. Further testing for each of these exposures is recommended because of the outdoor environment where the testing demonstration took place. This may cause the results to be inaccurate. It is feasible that the dust and noise levels will be higher in an enclosed environment. In addition, other safety and health issues found were ergonomics, heat stress, tripping hazards, electrical hazards, lockout/tagout, and arm-hand vibration

  2. PROGRESS IN THERMO-ABRASIVE BLASTING SYSTEMS

    Directory of Open Access Journals (Sweden)

    I.A. Gorlach

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Quality of surface preparation of components and structures for further painting and/or coating is important in many fields of engineering. One of the most widely used methods of surface preparation is abrasive blasting. In the last few years, a new method for surface preparation has evolved, namely thermo-abrasive blasting. This technique utilises a high enthalpy thermal jet, generated by the thermo-abrasive blasting gun, to propel abrasive particles. Thermo-abrasive blasting has a number of advantages over conventional abrasive blasting, which were assessed during trials. This paper describes a progress in the applications of thermo-abrasive blasting as well as future potentials for South African industry. The performance data and economic comparison of conventional and thermo-abrasive blasting are also presented in this paper.

    AFRIKAANSE OPSOMMING: Die gehalte van voorbereiding van komponent- en struktuuroppervlaktes is oral belangrik in ingenieurswesetoepassings. Wat vrywel tot die hede dikwels gebruik was, is straalskuring. Onlangs het 'n nuwe metode tot stand gekom naamlik termostraalskuring. Die metode maak gebruik van 'n hoë entalpie termostaat om skuurmiddel aan te dryf. Die nuwe metode besit sekere voordele in vergelyking met tradisionele straalskuring. Praktykbevestiging is hiervan met toetse verkry. Hierdie stuk bespreek ook die praktyktoepassings van termostraalskuring en die gepaardgaande voordele vir die Suid-Afrikaanse nywerheid. Toepassingsdata en ekomiese vergelyking van konvensionele- en termostraalskuring word ook behandel.

  3. PHOG-BLAST – a new generation tool for fast similarity search of protein families

    Directory of Open Access Journals (Sweden)

    Mironov Andrey A

    2006-06-01

    Full Text Available Abstract Background The need to compare protein profiles frequently arises in various protein research areas: comparison of protein families, domain searches, resolution of orthology and paralogy. The existing fast algorithms can only compare a protein sequence with a protein sequence and a profile with a sequence. Algorithms to compare profiles use dynamic programming and complex scoring functions. Results We developed a new algorithm called PHOG-BLAST for fast similarity search of profiles. This algorithm uses profile discretization to convert a profile to a finite alphabet and utilizes hashing for fast search. To determine the optimal alphabet, we analyzed columns in reliable multiple alignments and obtained column clusters in the 20-dimensional profile space by applying a special clustering procedure. We show that the clustering procedure works best if its parameters are chosen so that 20 profile clusters are obtained which can be interpreted as ancestral amino acid residues. With these clusters, only less than 2% of columns in multiple alignments are out of clusters. We tested the performance of PHOG-BLAST vs. PSI-BLAST on three well-known databases of multiple alignments: COG, PFAM and BALIBASE. On the COG database both algorithms showed the same performance, on PFAM and BALIBASE PHOG-BLAST was much superior to PSI-BLAST. PHOG-BLAST required 10–20 times less computer memory and computation time than PSI-BLAST. Conclusion Since PHOG-BLAST can compare multiple alignments of protein families, it can be used in different areas of comparative proteomics and protein evolution. For example, PHOG-BLAST helped to build the PHOG database of phylogenetic orthologous groups. An essential step in building this database was comparing protein complements of different species and orthologous groups of different taxons on a personal computer in reasonable time. When it is applied to detect weak similarity between protein families, PHOG-BLAST is less

  4. Blast overpressure and fallout radiation dose models for casualty assessment and other purposes. Rev. ed.

    International Nuclear Information System (INIS)

    Bentley, P.R.

    1981-12-01

    The determination of blast overpressures and fallout radiation doses at points on a sufficiently fine grid, for any part or for the whole of the UK, and for any postulated attack, is an essential element in the systematic assessment of casualties, the estimation of numbers of homeless, and the evaluation of life-saving measures generally. Models are described which provide the required blast and dose values and which are intended to supersede existing models which were introduced in 1971. The factors which affect blast and, more particularly, dose values are discussed, and the way in which various factors are modelled is described. The models are incorporated into separate computer programs which are described, the outputs of which are stored on magnetic tape for subsequent use as required. (author)

  5. A Blast Wave Model With Viscous Corrections

    Science.gov (United States)

    Yang, Z.; Fries, R. J.

    2017-04-01

    Hadronic observables in the final stage of heavy ion collision can be described well by fluid dynamics or blast wave parameterizations. We improve existing blast wave models by adding shear viscous corrections to the particle distributions in the Navier-Stokes approximation. The specific shear viscosity η/s of a hadron gas at the freeze-out temperature is a new parameter in this model. We extract the blast wave parameters with viscous corrections from experimental data which leads to constraints on the specific shear viscosity at kinetic freeze-out. Preliminary results show η/s is rather small.

  6. CO{sub 2} pellet blasting studies

    Energy Technology Data Exchange (ETDEWEB)

    Archibald, K.E.

    1997-01-01

    Initial tests with CO{sub 2} pellet blasting as a decontamination technique were completed in 1993 at the Idaho Chemical Processing Plant (ICPP) at the Idaho National Engineering Laboratory (INEL). During 1996, a number of additional CO{sub 2} pellet blasting studies with Alpheus Cleaning Technologies, Oak Ridge National Laboratory, and Pennsylvania State University were conducted. After the testing with Alpheus was complete, an SDI-5 shaved CO{sub 2} blasting unit was purchased by the ICPP to test and determine its capabilities before using in ICPP decontamination efforts. Results of the 1996 testing will be presented in this report.

  7. Blast Injuries: From Improvised Explosive Device Blasts to the Boston Marathon Bombing.

    Science.gov (United States)

    Singh, Ajay K; Ditkofsky, Noah G; York, John D; Abujudeh, Hani H; Avery, Laura A; Brunner, John F; Sodickson, Aaron D; Lev, Michael H

    2016-01-01

    Although most trauma centers have experience with the imaging and management of gunshot wounds, in most regions blast wounds such as the ones encountered in terrorist attacks with the use of improvised explosive devices (IEDs) are infrequently encountered outside the battlefield. As global terrorism becomes a greater concern, it is important that radiologists, particularly those working in urban trauma centers, be aware of the mechanisms of injury and the spectrum of primary, secondary, tertiary, and quaternary blast injury patterns. Primary blast injuries are caused by barotrauma from the initial increased pressure of the explosive detonation and the rarefaction of the atmosphere immediately afterward. Secondary blast injuries are caused by debris carried by the blast wind and most often result in penetrating trauma from small shrapnel. Tertiary blast injuries are caused by the physical displacement of the victim and the wide variety of blunt or penetrating trauma sustained as a result of the patient impacting immovable objects such as surrounding cars, walls, or fences. Quaternary blast injuries include all other injuries, such as burns, crush injuries, and inhalational injuries. Radiography is considered the initial imaging modality for assessment of shrapnel and fractures. Computed tomography is the optimal test to assess penetrating chest, abdominal, and head trauma. The mechanism of blast injuries and the imaging experience of the victims of the Boston Marathon bombing are detailed, as well as musculoskeletal, neurologic, gastrointestinal, and pulmonary injury patterns from blast injuries. ©RSNA, 2016.

  8. WARM JUPITERS NEED CLOSE ''FRIENDS'' FOR HIGH-ECCENTRICITY MIGRATION—A STRINGENT UPPER LIMIT ON THE PERTURBER'S SEPARATION

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Subo [Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Road 5, Hai Dian District, Beijing 100871 (China); Katz, Boaz; Socrates, Aristotle [Institute for Advanced Study, 1 Einstein Dr., Princeton, NJ 08540 (United States)

    2014-01-20

    We propose a stringent observational test on the formation of warm Jupiters (gas-giant planets with 10 days ≲ P ≲ 100 days) by high-eccentricity (high-e) migration mechanisms. Unlike hot Jupiters, the majority of observed warm Jupiters have pericenter distances too large to allow efficient tidal dissipation to induce migration. To access the close pericenter required for migration during a Kozai-Lidov cycle, they must be accompanied by a strong enough perturber to overcome the precession caused by general relativity, placing a strong upper limit on the perturber's separation. For a warm Jupiter at a ∼ 0.2 AU, a Jupiter-mass (solar-mass) perturber is required to be ≲ 3 AU (≲ 30 AU) and can be identified observationally. Among warm Jupiters detected by radial velocities (RVs), ≳ 50% (5 out of 9) with large eccentricities (e ≳ 0.4) have known Jovian companions satisfying this necessary condition for high-e migration. In contrast, ≲ 20% (3 out of 17) of the low-e (e ≲ 0.2) warm Jupiters have detected additional Jovian companions, suggesting that high-e migration with planetary perturbers may not be the dominant formation channel. Complete, long-term RV follow-ups of the warm-Jupiter population will allow a firm upper limit to be put on the fraction of these planets formed by high-e migration. Transiting warm Jupiters showing spin-orbit misalignments will be interesting to apply our test. If the misalignments are solely due to high-e migration as commonly suggested, we expect that the majority of warm Jupiters with low-e (e ≲ 0.2) are not misaligned, in contrast with low-e hot Jupiters.

  9. On firework blasts and qualitative parameter dependency.

    Science.gov (United States)

    Zohdi, T I

    2016-01-01

    In this paper, a mathematical model is developed to qualitatively simulate the progressive time-evolution of a blast from a simple firework. Estimates are made for the blast radius that one can expect for a given amount of detonation energy and pyrotechnic display material. The model balances the released energy from the initial blast pulse with the subsequent kinetic energy and then computes the trajectory of the material under the influence of the drag from the surrounding air, gravity and possible buoyancy. Under certain simplifying assumptions, the model can be solved for analytically. The solution serves as a guide to identifying key parameters that control the evolving blast envelope. Three-dimensional examples are given.

  10. Material Systems for Blast-Energy Dissipation

    Energy Technology Data Exchange (ETDEWEB)

    James Schondel; Henry S. Chu

    2010-10-01

    Lightweight panels have been designed to protect buildings and vehicles from blast pressures by activating energy dissipation mechanisms under the influence of blast loading. Panels were fabricated which featured a variety of granular materials and hydraulic dissipative deformation mechanisms and the test articles were subjected to full-scale blast loading. The force time-histories transmitted by each technology were measured by a novel method that utilized inexpensive custom-designed force sensors. The array of tests revealed that granular materials can effectively dissipate blast energy if they are employed in a way that they easily crush and rearrange. Similarly, hydraulic dissipation can effectively dissipate energy if the panel features a high fraction of porosity and the panel encasement features low compressive stiffness.

  11. Nucleon and Deuteron Form Factors from BLAST

    International Nuclear Information System (INIS)

    Hasell, D. K.

    2009-01-01

    The BLAST experiment was designed to study in a systematic manner the spin-dependent, electromagnetic interaction on hydrogen and deuterium. Measuring only asymmetries in electron scattering with respect to the beam helicity, target spin, or both; the BLAST experiment was able to extract information on nucleon and deuteron form factors independent of beam intensity or target density. By further forming 'super-ratios' of asymmetries, measurements were possible independent of beam and target polarization thus reducing uncertainties due to these quantities as well. Some of the form factor results from BLAST will be briefly presented here. Also, in response to observed discrepancies between polarization measurements and those obtained using traditional Rosenbluth separation techniques a proposed experiment, OLYMPUS, which will use the BLAST detector to measure the two photon contribution to elastic electron scattering will also be presented.

  12. Basic Local Alignment Search Tool (BLAST)

    Data.gov (United States)

    U.S. Department of Health & Human Services — BLAST finds regions of similarity between biological sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the...

  13. A Software Framework for Blast Event Simulation

    National Research Council Canada - National Science Library

    Swensen, D. A; Denison, M. K; Guilkey, James; Harman, Todd; Goetz, Richard

    2006-01-01

    .... The BCF will provide a virtual test-bed where disparate computational models can seamlessly interact with one another to provide a unified modeling solution for blast-vehicle-occupant scenarios...

  14. Blast effects physical properties of shock waves

    CERN Document Server

    2018-01-01

    This book compiles a variety of experimental data on blast waves. The book begins with an introductory chapter and proceeds to the topic of blast wave phenomenology, with a discussion Rankine-Hugoniot equations and the Friedlander equation, used to describe the pressure-time history of a blast wave. Additional topics include arrival time measurement, the initiation of detonation by exploding wires, a discussion of TNT equivalency, and small scale experiments. Gaseous and high explosive detonations are covered as well. The topics and experiments covered were chosen based on the comparison of used scale sizes, from small to large. Each characteristic parameter of blast waves is analyzed and expressed versus scaled distance in terms of energy and mass. Finally, the appendix compiles a number of polynomial laws that will prove indispensable for engineers and researchers.

  15. Prevention of Blast-Related Injuries

    Science.gov (United States)

    2017-09-01

    Award Number: W81XWH-12-2-0038 TITLE: Prevention of Blast-Related Injuries PRINCIPAL INVESTIGATOR: Albert I. King CONTRACTING ORGANIZATION...CONTRACT NUMBER Prevention of Blast-Related Injuries 5b. GRANT NUMBER W81XWH-12-2-0038 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Albert King, John...TR-7340). Army research lab Aberdeen proving ground MD weapons and materials research directorate. (2015) 11. Reneer, D.V., Hisel, R.D., Hoffman

  16. Blasting at a Superfund chemical waste site

    International Nuclear Information System (INIS)

    Burns, D.R.

    1991-01-01

    During the summer of 1989, Maine Drilling and Blasting of Gardiner, Maine was contracted by Cayer Corporation of Harvard, Massachusetts to drill and blast an interceptor trench at the Nyanza Chemical Superfund Site in Ashland, Massachusetts. The interceptor trench was to be 1,365 feet long and to be blasted out of granite. The trench was to be 12 feet wide at the bottom with 1/1 slopes, the deepest cut being 30 feet deep. A French drain 12 feet wide by 15 to 35 feet deep was blasted below the main trench on a 2% slope from its center to each end. A French drain is an excavation where the rock is blasted but not dug. The trench would be used as a perimeter road with any ground water flow going through the French drain flowing to both ends of the trench. Being a Superfund project turned a simple blasting project into a regulatory nightmare. The US Environmental Protection Agency performed all the chemical related functions on site. The US Army Corps of Engineers was overseeing all related excavation and construction on site, as was the Massachusetts Department of Environmental Quality Engineering, the local Hazardous Wastes Council, and the local Fire Department. All parties had some input with the blasting and all issues had to be addressed. The paper outlines the project, how it was designed and completed. Also included is an outline of the blast plan to be submitted for approval, an outline of the Safety/Hazardous Waste training and a description of all the problems which arose during the project by various regulatory agencies

  17. Are Dutch residents ready for a more stringent policy to enhance the energy performance of their homes?

    International Nuclear Information System (INIS)

    Middelkoop, Manon van; Vringer, Kees; Visser, Hans

    2017-01-01

    Investments in the energy performance of houses offer good prospects for reducing energy consumption and CO 2 emissions. However, people are not easily convinced of the need to take measures to improve the energy performance of their houses, even when financial benefits outweigh the costs. This article analyses the factors that influence the decision for improving the energy performance of existing homes, including policy instruments. Subsequently, the article provides policy suggestions on how to stimulate energy performance improvements. Both owners and tenants (50–70%) support government policy on energy performance improvements to existing homes. Nevertheless, people also have strong feelings of autonomy regarding their homes. Our results underline the importance of well-informed and competent decision-makers. Introducing the use of Energy Performance Certificates (EPCs) into the tax system for energy and residential buildings might therefore be an effective way to increase the interest of owners in the EPC, improve the use and effect of this informative instrument, and make the first step towards bridging the tension between autonomy and more stringent instruments.

  18. Investigation of head response to blast loading.

    Science.gov (United States)

    Lockhart, Philip; Cronin, Duane; Williams, Kevin; Ouellet, Simon

    2011-02-01

    Head injury resulting from blast loading, specifically mild traumatic brain injury, has been identified as a possible and important blast-related injury for soldiers in modern conflict zones. A study was undertaken to evaluate head response to blast loading scenarios using an explicit finite element numerical model and to comment on the potential for head injury. The blast loading and simplified human body numerical models were validated using impulse, peak acceleration and the Head Injury Criterion from experimental blast test data. A study was then undertaken to evaluate head response at varying distances and orientations from the explosive. The accelerations and injury metrics for the head increased with decreasing distance to the explosive, as expected, but were also significant at intermediate distances from the explosive for larger charge sizes and intermediate heights of burst. Varying lateral position with constant standoff did not have a significant effect on the head kinematic response. The head injury criteria considered were exceeded in close proximity to the explosive (blast loading, aggressive loading is predicted at small standoff distances and confirmed by the resulting head kinematics.

  19. The second generation of electronic blasting systems

    Energy Technology Data Exchange (ETDEWEB)

    Hammelmann, F.; Petzold, J. [Dynamit Nobel GmbH (Germany)

    2001-07-01

    8 years after the market introduction of the first commercial electronic detonator - DYNATRONIC - the paper describes a new area of electronic blasting systems Made in Germany: i-kon. The results of a joint development between Dynamit Nobel and Orica is a unique universal electronic detonator, which is as simple to use as a standard non-electric detonator. The delay time or delay interval is not factory preprogrammed and the system is not based on a numbered system like conventional detonators. The miner or Blaster decides on site which delay timing he likes to use and is programming the whole blast on site. The new i-kon system allows delay times between 0 and 8000 ms by increments of 1 ms. With the control equipment it is possible to blast up to 1600 detonators in a single blast. The paper describes the construction and functionality of this new electronic blasting system - manufactured and developed by Precision Blasting Systems, a joint venture between Orica and Dynamic Nobel. (orig.)

  20. The PARIGA server for real time filtering and analysis of reciprocal BLAST results.

    Directory of Open Access Journals (Sweden)

    Massimiliano Orsini

    Full Text Available BLAST-based similarity searches are commonly used in several applications involving both nucleotide and protein sequences. These applications span from simple tasks such as mapping sequences over a database to more complex procedures as clustering or annotation processes. When the amount of analysed data increases, manual inspection of BLAST results become a tedious procedure. Tools for parsing or filtering BLAST results for different purposes are then required. We describe here PARIGA (http://resources.bioinformatica.crs4.it/pariga/, a server that enables users to perform all-against-all BLAST searches on two sets of sequences selected by the user. Moreover, since it stores the two BLAST output in a python-serialized-objects database, results can be filtered according to several parameters in real-time fashion, without re-running the process and avoiding additional programming efforts. Results can be interrogated by the user using logical operations, for example to retrieve cases where two queries match same targets, or when sequences from the two datasets are reciprocal best hits, or when a query matches a target in multiple regions. The Pariga web server is designed to be a helpful tool for managing the results of sequence similarity searches. The design and implementation of the server renders all operations very fast and easy to use.

  1. The PARIGA server for real time filtering and analysis of reciprocal BLAST results.

    Science.gov (United States)

    Orsini, Massimiliano; Carcangiu, Simone; Cuccuru, Gianmauro; Uva, Paolo; Tramontano, Anna

    2013-01-01

    BLAST-based similarity searches are commonly used in several applications involving both nucleotide and protein sequences. These applications span from simple tasks such as mapping sequences over a database to more complex procedures as clustering or annotation processes. When the amount of analysed data increases, manual inspection of BLAST results become a tedious procedure. Tools for parsing or filtering BLAST results for different purposes are then required. We describe here PARIGA (http://resources.bioinformatica.crs4.it/pariga/), a server that enables users to perform all-against-all BLAST searches on two sets of sequences selected by the user. Moreover, since it stores the two BLAST output in a python-serialized-objects database, results can be filtered according to several parameters in real-time fashion, without re-running the process and avoiding additional programming efforts. Results can be interrogated by the user using logical operations, for example to retrieve cases where two queries match same targets, or when sequences from the two datasets are reciprocal best hits, or when a query matches a target in multiple regions. The Pariga web server is designed to be a helpful tool for managing the results of sequence similarity searches. The design and implementation of the server renders all operations very fast and easy to use.

  2. Recovery Act: ArcelorMittal USA Blast Furnace Gas Flare Capture

    Energy Technology Data Exchange (ETDEWEB)

    Seaman, John

    2013-01-14

    The U.S. Department of Energy (DOE) awarded a financial assistance grant under the American Recovery and Reinvestment Act of 2009 (Recovery Act) to ArcelorMittal USA, Inc. (ArcelorMittal) for a project to construct and operate a blast furnace gas recovery boiler and supporting infrastructure at ArcelorMittal’s Indiana Harbor Steel Mill in East Chicago, Indiana. Blast furnace gas (BFG) is a by-product of blast furnaces that is generated when iron ore is reduced with coke to create metallic iron. BFG has a very low heating value, about 1/10th the heating value of natural gas. BFG is commonly used as a boiler fuel; however, before installation of the gas recovery boiler, ArcelorMittal flared 22 percent of the blast furnace gas produced at the No. 7 Blast Furnace at Indiana Harbor. The project uses the previously flared BFG to power a new high efficiency boiler which produces 350,000 pounds of steam per hour. The steam produced is used to drive existing turbines to generate electricity and for other requirements at the facility. The goals of the project included job creation and preservation, reduced energy consumption, reduced energy costs, environmental improvement, and sustainability.

  3. Raydet non-electric blast initiation system for efficient and environment-friendly surface blasts

    Energy Technology Data Exchange (ETDEWEB)

    Sarathy, M.O. [IDL Chemicals Ltd., Hyderabad (India). Technical Services Cell

    1995-08-01

    This paper discusses the advantages of using the Raydet shock tube based blast initiation system and reviews research work carried out on release of explosive energy in the drillhole, effect of stemming retention (stemming effectiveness) and advantages of `true bottom hole initiation` of drillholes in surface blasting. Some case studies are presented. 6 refs., 5 figs., 1 tab.

  4. Reducing Drill and Blast Cost through Blast Optimisation – A Case ...

    African Journals Online (AJOL)

    Michael O. Mensah

    2015-12-02

    Dec 2, 2015 ... gold mine in Ghana, and further developed a suitable, cost-effective drill and blast geometric parameters for the mine. The study was conducted on three ... explosive type, density and costs; labour; oversize. (relative boulders), toes and ... garnering input data, and in its direct linkage between blast design ...

  5. Low Complexity V-BLAST MIMO-OFDM Detector by Successive Iterations Reduction

    Directory of Open Access Journals (Sweden)

    AHMED, K.

    2015-02-01

    Full Text Available V-BLAST detection method suffers large computational complexity due to its successive detection of symbols. In this paper, we propose a modified V-BLAST algorithm to decrease the computational complexity by reducing the number of detection iterations required in MIMO communication systems. We begin by showing the existence of a maximum number of iterations, beyond which, no significant improvement is obtained. We establish a criterion for the number of maximum effective iterations. We propose a modified algorithm that uses the measured SNR to dynamically set the number of iterations to achieve an acceptable bit-error rate. Then, we replace the feedback algorithm with an approximate linear function to reduce the complexity. Simulations show that significant reduction in computational complexity is achieved compared to the ordinary V-BLAST, while maintaining a good BER performance.

  6. BLAST-EXPLORER helps you building datasets for phylogenetic analysis

    Directory of Open Access Journals (Sweden)

    Claverie Jean-Michel

    2010-01-01

    Full Text Available Abstract Background The right sampling of homologous sequences for phylogenetic or molecular evolution analyses is a crucial step, the quality of which can have a significant impact on the final interpretation of the study. There is no single way for constructing datasets suitable for phylogenetic analysis, because this task intimately depends on the scientific question we want to address, Moreover, database mining softwares such as BLAST which are routinely used for searching homologous sequences are not specifically optimized for this task. Results To fill this gap, we designed BLAST-Explorer, an original and friendly web-based application that combines a BLAST search with a suite of tools that allows interactive, phylogenetic-oriented exploration of the BLAST results and flexible selection of homologous sequences among the BLAST hits. Once the selection of the BLAST hits is done using BLAST-Explorer, the corresponding sequence can be imported locally for external analysis or passed to the phylogenetic tree reconstruction pipelines available on the Phylogeny.fr platform. Conclusions BLAST-Explorer provides a simple, intuitive and interactive graphical representation of the BLAST results and allows selection and retrieving of the BLAST hit sequences based a wide range of criterions. Although BLAST-Explorer primarily aims at helping the construction of sequence datasets for further phylogenetic study, it can also be used as a standard BLAST server with enriched output. BLAST-Explorer is available at http://www.phylogeny.fr

  7. Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response toMoraxella catarrhalisProteins.

    Science.gov (United States)

    Ren, Dabin; Murphy, Timothy F; Lafontaine, Eric R; Pichichero, Michael E

    2017-01-01

    Moraxella catarrhalis ( Mcat ) is a prominent mucosal pathogen causing acute otitis media (AOM). We studied Mcat nasopharyngeal (NP) colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP) CD, oligopeptide permease (Opp) A, hemagglutinin (Hag), and Pilin A clade 2 (PilA2) from stringently defined otitis prone (sOP) children, who experience the greatest burden of disease, compared to non-otitis prone (NOP) children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P  = 0.0003) and Mcat -caused AOM rates (49 vs. 24%, P  P  P  = 0.018), Hag (IgG and IgA, both P  P  P  = 0.039) and PilA2 ( P  = 0.0076), and IgA to OMP CD ( P  = 0.010), OppA ( P  = 0.030), and PilA2 ( P  = 0.043) were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD ( P  = 0.0070) and Hag ( P  = 0.0003), and IgA to Hag ( P  = 0.0067) at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P  NP colonization and NP colonization progressing to Mcat -caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children.

  8. Stringent constraints on the dark matter annihilation cross section from subhalo searches with the Fermi Gamma-Ray Space Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Berlin, Asher; Hooper, Dan

    2014-01-01

    The dark matter halo of the Milky Way is predicted to contain a very large number of smaller subhalos. As a result of the dark matter annihilations taking place within such objects, the most nearby and massive subhalos could appear as point-like or spatially extended gamma-ray sources, without observable counterparts at other wavelengths. In this paper, we use the results of the Aquarius simulation to predict the distribution of nearby subhalos, and compare this to the characteristics of the unidentified gamma-ray sources observed by the Fermi Gamma-Ray Space Telescope. Focusing on the brightest high latitude sources, we use this comparison to derive limits on the dark matter annihilation cross section. For dark matter particles lighter than ~200 GeV, the resulting limits are the strongest obtained to date, being modestly more stringent than those derived from observations of dwarf galaxies or the Galactic Center. We also derive independent limits based on the lack of unidentified gamma-ray sources with discernible spatial extension, but these limits are a factor of ~2-10 weaker than those based on point-like subhalos. Lastly, we note that four of the ten brightest high-latitude sources exhibit a similar spectral shape, consistent with 30-60 GeV dark matter particles annihilating to b quarks with an annihilation cross section on the order of sigma v ~ (5-10) x 10^-27 cm^3/s, or 8-10 GeV dark matter particles annihilating to taus with sigma v ~ (2.0-2.5) x 10^-27 cm^3/s.

  9. Research on Effects of Blast Casting Vibration and Vibration Absorption of Presplitting Blasting in Open Cast Mine

    Directory of Open Access Journals (Sweden)

    Li Ma

    2016-01-01

    Full Text Available The impact energy produced by blast casting is able to break and cast rocks, yet the strong vibration effects caused at the same time would threaten the safety of mines. Based on the theory of Janbu’s Limit Equilibrium Method (LEM, pseudo-static method has been incorporated to analyze the influence of dynamic loads of blasting on slope stability. The horizontal loads produced by blast vibrations cause an increase in sliding forces, and this leads to a lower slope stability coefficient. When the tensile stresses of the two adjacent blast holes are greater than the tensile strength of rock mass, the radical oriented cracks are formed, which is the precondition for the formation of presplit face. Thus, the formula for calculating the blast hole spacing of presplit blasting can be obtained. Based on the analysis of the principles of vibration tester and vibration pick-up in detecting blast vibrations, a detection scheme of blast vibration is worked out by taking the blast area with precrack rear and non-precrack side of the detection object. The detection and research results of blast vibration show that presplit blasting can reduce the attenuation coefficient of stress wave by half, and the vibration absorption ratio could reach 50.2%; the impact of dynamic loads on the end-wall slope stability coefficient is 1.98%, which proves that presplit blasting plays an important role in shock absorption of blast casting.

  10. Experimental Measures of Blast and Acoustic Trauma in Marine Mammals

    National Research Council Canada - National Science Library

    Ketten, Darlene R

    2004-01-01

    .... To determine onset of damage zones for blast trauma in marine mammals, fresh post-mortem specimens were implanted with pressure gages, CT scanned, and exposed to underwater blast pressures of 10-300 psi...

  11. Effectiveness of eye armor during blast loading.

    Science.gov (United States)

    Bailoor, Shantanu; Bhardwaj, Rajneesh; Nguyen, Thao D

    2015-11-01

    Ocular trauma is one of the most common types of combat injuries resulting from the interaction of military personnel with improvised explosive devices. Ocular blast injury mechanisms are complex, and trauma may occur through various injury mechanisms. However, primary blast injuries (PBI) are an important cause of ocular trauma that may go unnoticed and result in significant damage to internal ocular tissues and visual impairment. Further, the effectiveness of commonly employed eye armor, designed for ballistic and laser protection, in lessening the severity of adverse blast overpressures (BOP) is unknown. In this paper, we employed a three-dimensional (3D) fluid-structure interaction computational model for assessing effectiveness of the eye armor during blast loading on human eyes and validated results against free field blast measurements by Bentz and Grimm (2013). Numerical simulations show that the blast waves focused on the ocular region because of reflections from surrounding facial features and resulted in considerable increase in BOP. We evaluated the effectiveness of spectacles and goggles in mitigating the pressure loading using the computational model. Our results corroborate experimental measurements showing that the goggles were more effective than spectacles in mitigating BOP loading on the eye. Numerical results confirmed that the goggles significantly reduced blast wave penetration in the space between the armor and the eyes and provided larger clearance space for blast wave expansion after penetration than the spectacles. The spectacles as well as the goggles were more effective in reducing reflected BOP at higher charge mass because of the larger decrease in dynamic pressures after the impact. The goggles provided greater benefit of reducing the peak pressure than the spectacles for lower charge mass. However, the goggles resulted in moderate, sustained elevated pressure loading on the eye, that became 50-100% larger than the pressure loading

  12. A blast absorber test: measurement and model results

    NARCIS (Netherlands)

    Eerden, F.J.M. van der; Berg, F. van den; Hof, J. van 't; Arkel, E. van

    2006-01-01

    A blast absorber test was conducted at the Aberdeen Test Centre from 13 to 17 June 2005. The test was set up to determine the absorbing and shielding effect of a gravel pile, of 1.5 meters high and 15 by 15 meters wide, on blasts from large weapons: e.g. armor, artillery or demolition. The blast was

  13. Inheritance of blast resistance and identification of SSR marker ...

    Indian Academy of Sciences (India)

    2013-08-02

    Aug 2, 2013 ... An F2 population was developed from a cross between rice. (Oryza sativa L.) genotypes, EK 70 (highly susceptible to blast) and RDN 98-2-3-5-14 (resistant to blast), to study the inheritance of blast resistance and to identify the marker associated with resistance. The F2 population segregated in 3:1 ratio for ...

  14. VRPI Temporal Progression of Closed Globe Injury from Blast Exposure

    Science.gov (United States)

    2015-09-01

    significant increases in VEGF have been reported in many ocular disorders including diabetic retinopathy , diffuse macular edema, retinal vein...FRIEDLANDER SHAPED BLAST WAVES. FIGURE 2. BLAST WAVE MEASURED 1-IN IN FRONT OF ANIMAL LOCATION COMPARED TO PREDICTION OF BLAST FROM FRIEDLANDER WAVE

  15. Blast Impact Prediction Studies at Ghana Manganese Company ...

    African Journals Online (AJOL)

    Michael

    2015-06-01

    Jun 1, 2015 ... Amegbey, N. and Afum, B. O. (2015), Blast Impact Prediction Studies at Ghana Manganese Company (GMC). Ltd, Nsuta ... conduct safe blasting operations in the Pit C North, studies were undertaken to assess the environmental impacts of blast associated with ..... Technology for Construction and Mining,.

  16. High-speed imaging and small-scale explosive characterization techniques to understand effects of primary blast-induced injury on nerve cell structure and function

    Science.gov (United States)

    Piehler, T.; Banton, R.; Zander, N.; Duckworth, J.; Benjamin, R.; Sparks, R.

    2018-01-01

    Traumatic brain injury (TBI) is often associated with blast exposure. Even in the absence of penetrating injury or evidence of tissue injury on imaging, blast TBI may trigger a series of neural/glial cellular and functional changes. Unfortunately, the diagnosis and proper treatment of mild traumatic brain injury (mTBI) caused by explosive blast is challenging, as it is not easy to clinically distinguish blast from non-blast TBI on the basis of patient symptoms. Damage to brain tissue, cell, and subcellular structures continues to occur slowly and in a manner undetectable by conventional imaging techniques. The threshold shock impulse levels required to induce damage and the cumulative effects upon multiple exposures are not well characterized. Understanding how functional and structural damage from realistic blast impact at cellular and tissue levels at variable timescales after mTBI events may be vital for understanding this injury phenomenon and for linking mechanically induced structural changes with measurable effects on the nervous system. Our working hypothesis is that there is some transient physiological dysfunction occurring at cellular and subcellular levels within the central nervous system due to primary blast exposure. We have developed a novel in vitro indoor experimental system that uses real military explosive charges to more accurately represent military blast exposure and to probe the effects of primary explosive blast on dissociated neurons. We believe this system offers a controlled experimental method to analyze and characterize primary explosive blast-induced cellular injury and to understand threshold injury phenomenon. This paper will also focus on the modeling aspect of our work and how it relates to the experimental work.

  17. Modelling human eye under blast loading.

    Science.gov (United States)

    Esposito, L; Clemente, C; Bonora, N; Rossi, T

    2015-01-01

    Primary blast injury (PBI) is the general term that refers to injuries resulting from the mere interaction of a blast wave with the body. Although few instances of primary ocular blast injury, without a concomitant secondary blast injury from debris, are documented, some experimental studies demonstrate its occurrence. In order to investigate PBI to the eye, a finite element model of the human eye using simple constitutive models was developed. The material parameters were calibrated by a multi-objective optimisation performed on available eye impact test data. The behaviour of the human eye and the dynamics of mechanisms occurring under PBI loading conditions were modelled. For the generation of the blast waves, different combinations of explosive (trinitrotoluene) mass charge and distance from the eye were analysed. An interpretation of the resulting pressure, based on the propagation and reflection of the waves inside the eye bulb and orbit, is proposed. The peculiar geometry of the bony orbit (similar to a frustum cone) can induce a resonance cavity effect and generate a pressure standing wave potentially hurtful for eye tissues.

  18. Automated information system for analysis and prediction of production situations in blast furnace plant

    Science.gov (United States)

    Lavrov, V. V.; Spirin, N. A.

    2016-09-01

    Advances in modern science and technology are inherently connected with the development, implementation, and widespread use of computer systems based on mathematical modeling. Algorithms and computer systems are gaining practical significance solving a range of process tasks in metallurgy of MES-level (Manufacturing Execution Systems - systems controlling industrial process) of modern automated information systems at the largest iron and steel enterprises in Russia. This fact determines the necessity to develop information-modeling systems based on mathematical models that will take into account the physics of the process, the basics of heat and mass exchange, the laws of energy conservation, and also the peculiarities of the impact of technological and standard characteristics of raw materials on the manufacturing process data. Special attention in this set of operations for metallurgic production is devoted to blast-furnace production, as it consumes the greatest amount of energy, up to 50% of the fuel used in ferrous metallurgy. The paper deals with the requirements, structure and architecture of BF Process Engineer's Automated Workstation (AWS), a computer decision support system of MES Level implemented in the ICS of the Blast Furnace Plant at Magnitogorsk Iron and Steel Works. It presents a brief description of main model subsystems as well as assumptions made in the process of mathematical modelling. Application of the developed system allows the engineering and process staff to analyze online production situations in the blast furnace plant, to solve a number of process tasks related to control of heat, gas dynamics and slag conditions of blast-furnace smelting as well as to calculate the optimal composition of blast-furnace slag, which eventually results in increasing technical and economic performance of blast-furnace production.

  19. Structural dynamic and resistance to nuclear air blast

    International Nuclear Information System (INIS)

    Qureshi, S.M.

    2003-01-01

    A need exists to design protective shelters attached to specialized facilities against nuclear airbursts, explosive shocks and impacting projectiles. Designing such structures against nuclear and missile impact is a challenging task that needs to be looked into for design methodology formulation and practicability. Structures can be designed for overpressure pulsed generated by a nuclear explosion as well as the scabbing and perforation/punching of an impacting projectile. This paper discuses and formulates the methods of dynamic analysis and design required to undertake such a task. Structural resistance to peak overpressure pulse for a 20 KT weapons and smaller tactical nuclear weapons of 1 KT (16 psi, overpressure) size as a direct air blast overpressure has been considered in design of walls, beams and slabs of a special structure under review. The design of shear reinforcement as lacing is also carried out. Adopting the philosophy of strengthening and hardening can minimize the effect of air blast overpressure and projectile impact. The objective is to avoid a major structural failure. The structure then needs to be checked against ballistic penetration by a range of weapons or be required to resist explosive penetration from the charge detonated in contact with the structure. There is also a dire need to formulate protective guidelines for all existing and future critical facilities. (author)

  20. Blast-induced traumatic brain injury: a new trend of blast injury research.

    Science.gov (United States)

    Zhao, Yan; Wang, Zheng-Guo

    2015-01-01

    Blast injury has become the major life- and function-threatening injuries in recent warfares. There is increased research interest in the mental disorders caused by blast-induced traumatic brain injury (bTBI), which has been proved as one of the "signature wounds" in modern battlefield. We reviewed the recent progresses in bTBI-related researches and concluded that the new era of blast injury research has shifted from the traditional physical impairments to cognitive dysfunctional/mental disorders that are proved to be more related to the outcome of combat casualty care.

  1. Work Management Manual - Blast and Paint General

    Science.gov (United States)

    1983-08-01

    material which accelerates the har- dening of certain coatinss. Acoustic paint - paint which absorbs or deadens sound . Acrylic resin-a clear resin...AUG 1983 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Work Managemaent Manual - Blast and Paint General 5a. CONTRACT NUMBER...WORK MANAGEMENT MANUAL BLAST/ PAINT GENERAL INDEX SECTION PAGE 1.0 .1 .2 .3 .4 2.0 .1 .2 .3 .4 .5 .6 .8 .9 3.0 .1 4.0 .1 5.0 .1 7.0 .1 .3 8.0 SCOPE PLANT

  2. Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces.

    Science.gov (United States)

    Newman, Andrew J; Hayes, Sarah H; Rao, Abhiram S; Allman, Brian L; Manohar, Senthilvelan; Ding, Dalian; Stolzberg, Daniel; Lobarinas, Edward; Mollendorf, Joseph C; Salvi, Richard

    2015-03-15

    Military personnel and civilians living in areas of armed conflict have increased risk of exposure to blast overpressures that can cause significant hearing loss and/or brain injury. The equipment used to simulate comparable blast overpressures in animal models within laboratory settings is typically very large and prohibitively expensive. To overcome the fiscal and space limitations introduced by previously reported blast wave generators, we developed a compact, low-cost blast wave generator to investigate the effects of blast exposures on the auditory system and brain. The blast wave generator was constructed largely from off the shelf components, and reliably produced blasts with peak sound pressures of up to 198dB SPL (159.3kPa) that were qualitatively similar to those produced from muzzle blasts or explosions. Exposure of adult rats to 3 blasts of 188dB peak SPL (50.4kPa) resulted in significant loss of cochlear hair cells, reduced outer hair cell function and a decrease in neurogenesis in the hippocampus. Existing blast wave generators are typically large, expensive, and are not commercially available. The blast wave generator reported here provides a low-cost method of generating blast waves in a typical laboratory setting. This compact blast wave generator provides scientists with a low cost device for investigating the biological mechanisms involved in blast wave injury to the rodent cochlea and brain that may model many of the damaging effects sustained by military personnel and civilians exposed to intense blasts. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. A computational model of blast loading on the human eye.

    Science.gov (United States)

    Bhardwaj, Rajneesh; Ziegler, Kimberly; Seo, Jung Hee; Ramesh, K T; Nguyen, Thao D

    2014-01-01

    Ocular injuries from blast have increased in recent wars, but the injury mechanism associated with the primary blast wave is unknown. We employ a three-dimensional fluid-structure interaction computational model to understand the stresses and deformations incurred by the globe due to blast overpressure. Our numerical results demonstrate that the blast wave reflections off the facial features around the eye increase the pressure loading on and around the eye. The blast wave produces asymmetric loading on the eye, which causes globe distortion. The deformation response of the globe under blast loading was evaluated, and regions of high stresses and strains inside the globe were identified. Our numerical results show that the blast loading results in globe distortion and large deviatoric stresses in the sclera. These large deviatoric stresses may be indicator for the risk of interfacial failure between the tissues of the sclera and the orbit.

  4. Blast noise classification with common sound level meter metrics.

    Science.gov (United States)

    Cvengros, Robert M; Valente, Dan; Nykaza, Edward T; Vipperman, Jeffrey S

    2012-08-01

    A common set of signal features measurable by a basic sound level meter are analyzed, and the quality of information carried in subsets of these features are examined for their ability to discriminate military blast and non-blast sounds. The analysis is based on over 120 000 human classified signals compiled from seven different datasets. The study implements linear and Gaussian radial basis function (RBF) support vector machines (SVM) to classify blast sounds. Using the orthogonal centroid dimension reduction technique, intuition is developed about the distribution of blast and non-blast feature vectors in high dimensional space. Recursive feature elimination (SVM-RFE) is then used to eliminate features containing redundant information and rank features according to their ability to separate blasts from non-blasts. Finally, the accuracy of the linear and RBF SVM classifiers is listed for each of the experiments in the dataset, and the weights are given for the linear SVM classifier.

  5. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (pppGpp synthase

    Directory of Open Access Journals (Sweden)

    Kalinowski Jörn

    2006-09-01

    Full Text Available Background The stringent response is the initial reaction of microorganisms to nutritional stress. During stringent response the small nucleotides (pppGpp act as global regulators and reprogram bacterial transcription. In this work, the genetic network controlled by the stringent response was characterized in the amino acid-producing Corynebacterium glutamicum. Results The transcriptome of a C. glutamicum rel gene deletion mutant, unable to synthesize (pppGpp and to induce the stringent response, was compared with that of its rel-proficient parent strain by microarray analysis. A total of 357 genes were found to be transcribed differentially in the rel-deficient mutant strain. In a second experiment, the stringent response was induced by addition of DL-serine hydroxamate (SHX in early exponential growth phase. The time point of the maximal effect on transcription was determined by real-time RT-PCR using the histidine and serine biosynthetic genes. Transcription of all of these genes reached a maximum at 10 minutes after SHX addition. Microarray experiments were performed comparing the transcriptomes of SHX-induced cultures of the rel-proficient strain and the rel mutant. The differentially expressed genes were grouped into three classes. Class A comprises genes which are differentially regulated only in the presence of an intact rel gene. This class includes the non-essential sigma factor gene sigB which was upregulated and a large number of genes involved in nitrogen metabolism which were downregulated. Class B comprises genes which were differentially regulated in response to SHX in both strains, independent of the rel gene. A large number of genes encoding ribosomal proteins fall into this class, all being downregulated. Class C comprises genes which were differentially regulated in response to SHX only in the rel mutant. This class includes genes encoding putative stress proteins and global transcriptional regulators that might be

  6. RegExpBlasting (REB), a Regular Expression Blasting algorithm based on multiply aligned sequences

    OpenAIRE

    Rubino, Francesco; Attimonelli, Marcella

    2009-01-01

    Background One of the most frequent uses of bioinformatics tools concerns functional characterization of a newly produced nucleotide sequence (a query sequence) by applying Blast or FASTA against a set of sequences (the subject sequences). However, in some specific contexts, it is useful to compare the query sequence against a cluster such as a MultiAlignment (MA). We present here the RegExpBlasting (REB) algorithm, which compares an unclassified sequence with a dataset of patterns defined by...

  7. [Certain theoretical-methodological problems of forensic medical expertise of the blast injury].

    Science.gov (United States)

    Popov, V L

    2015-01-01

    This article is devoted to the analysis of the theoretical problems facing forensic medical expertise of the blast injury. The original notions of the blast, injurious blast factors, and their traumatic consequences are proposed together with the classification of the blasts and their injurious factors. The principal lines of the further research on the forensic medical aspects of the blast injury are formulated.

  8. Consideration on local blast vibration control by delay blasting; Danpatsu happa ni yoru kyokuchiteki shindo seigyo ni kansuru ichikosatsu

    Energy Technology Data Exchange (ETDEWEB)

    Mogi, Gento; Adachi, Tsuyoshi; Yamatomi, Jiro [The University of Tokyo School of Engineering Department of Geosystem Engineering, Tokyo (Japan); Hoshino, Tatsuya [Mitsui Mining and Smelting Corp., Tokyo (Japan)

    1999-10-31

    In this research, local blast vibration control based on the theory of superposition of waves was investigated. Firstly, the influence of delay time errors of conventional electric detonators upon the level of local blast vibration was examined. Secondly, for a further effective local blast vibration control, a new delay blasting design concept 'combined delay blasting' that postulates the use of electronic detonators, which virtually have no delay time errors, is proposed. For a delay blasting with uniform detonation time intervals, an optimum time interval to minimize the local PPV (Peak Particle Velocity) is obtained based on the relationship between the PPV and the time interval, which is derived by superposing identical vibration time histories of each single hole shot. However, due to the scattering of the actual delay time caused by errors, PPV of a production blast seldom coincides with the estimated one. Since the expected value and the variance of PPV mainly depend on sensitivity of PPV around the nominal delay time, it is proposed that not only the optimum but also several sub-optimum candidates of delay time should be examined taking error into consideration. Concerning the 'combined delay blasting', its concept and some simulation results are presented. The estimated reduction effect of blast vibration of a delay blast based on this concept was quite favorable, indicating a possibility for further effective local blast vibration control. (author)

  9. Developments in vapour cloud explosion blast modeling

    NARCIS (Netherlands)

    Mercx, W.P.M.; Berg, A.C. van den; Hayhurst, C.J.; Robertson, N.J.; Moran, K.C.

    2000-01-01

    TNT Equivalency methods are widely used for vapour cloud explosion blast modeling. Presently, however, other types of models are available which do not have the fundamental objections TNT Equivalency models have. TNO Multi-Energy method is increasingly accepted as a more reasonable alternative to be

  10. Ignition systems and blasting accessories; L'amorcage et les accessoires de tir

    Energy Technology Data Exchange (ETDEWEB)

    Du Mouza, J. [Ecole Nationale Superieure des Mines, 75 - Paris (France); Monnery, J. [SFEPA, 92 - Puteaux (France); Vuillaume, P. [Institut National de l' Environnement Industriel et des Risques, 60 - Verneuil en Halatte (INERIS) (France); Cervellera, St. [Titanite SA, 21 - Pontailler sur Saone (France); Houeix, T.

    2002-03-01

    1. General: Blasting caps or detonators are the main elements of the pyrotechnical sequence. They should be reliable in order to guaranty the quality, the safety and the energy liberated by the explosive. They transmit to the explosive the minimum required energy to initiate the detonation. The pyrotechnical sequence comprises a mechanical or electrical device, the blasting cap able to produce a shock or a spark initiating the explosion directly or through a primary explosive more sensible than the main one. 2. Initiation systems: Various types of systems are described determining the way the shock wave is propagated within the explosive. Initiation may be made punctually, by means of a detonator or laterally by means of a cord. Detonators may be operated electrically, non-electrically or electronically. Special devices allow for the retardation of the initiation. 3. Retardation reliability and accuracy: Some points about the consequences of dispersions in lengths of retardation of detonators such as the possible overlapping of explosive loads and combination of vibration trains in the environment are discussed. A smaller dispersion offered by electronic detonators, which are by far the most frequently used, should be able to overcome these difficulties. 4. Impact of the initiation on the explosive yield: The way the ignition is performed has a direct consequence on the yield of the explosive. When a primer explosive is utilised as a booster, various factors (weight, position and diameter) play an important role on the detonation pressure and speed. A chart indicates the explosive energy liberated depending on the way ignition is performed. 5. Blasting accessories: Dynamos were largely used in the past to generate the electric current required to actuate blasting caps. Now this electric current is generated by the discharge of capacitors associated with electronic devices to control the blasting sequence. Ohmmeters are also used to check the electric circuits

  11. Genome-Wide Association of Rice Blast Disease Resistance and Yield-Related Components of Rice.

    Science.gov (United States)

    Wang, Xueyan; Jia, Melissa H; Ghai, Pooja; Lee, Fleet N; Jia, Yulin

    2015-12-01

    Robust disease resistance may require an expenditure of energy that may limit crop yield potential. In the present study, a subset of a United States Department of Agriculture rice core collection consisting of 151 accessions was selected using a major blast resistance (R) gene, Pi-ta, marker and was genotyped with 156 simple sequence repeat (SSR) markers. Disease reactions to Magnaporthe oryzae, the causal agent of rice blast disease, were evaluated under greenhouse and field conditions, and heading date, plant height, paddy and brown seed weight in two field environments were analyzed, using an association mapping approach. A total of 21 SSR markers distributed among rice chromosomes 2 to 12 were associated with blast resistance, and 16 SSR markers were associated with seed weight, heading date, and plant height. Most noticeably, shorter plants were significantly correlated with resistance to blast, rice genomes with Pi-ta were associated with lighter seed weights, and the susceptible alleles of RM171 and RM6544 were associated with heavier seed weight. These findings unraveled a complex relationship between disease resistance and yield-related components.

  12. BlastNeuron for Automated Comparison, Retrieval and Clustering of 3D Neuron Morphologies.

    Science.gov (United States)

    Wan, Yinan; Long, Fuhui; Qu, Lei; Xiao, Hang; Hawrylycz, Michael; Myers, Eugene W; Peng, Hanchuan

    2015-10-01

    Characterizing the identity and types of neurons in the brain, as well as their associated function, requires a means of quantifying and comparing 3D neuron morphology. Presently, neuron comparison methods are based on statistics from neuronal morphology such as size and number of branches, which are not fully suitable for detecting local similarities and differences in the detailed structure. We developed BlastNeuron to compare neurons in terms of their global appearance, detailed arborization patterns, and topological similarity. BlastNeuron first compares and clusters 3D neuron reconstructions based on global morphology features and moment invariants, independent of their orientations, sizes, level of reconstruction and other variations. Subsequently, BlastNeuron performs local alignment between any pair of retrieved neurons via a tree-topology driven dynamic programming method. A 3D correspondence map can thus be generated at the resolution of single reconstruction nodes. We applied BlastNeuron to three datasets: (1) 10,000+ neuron reconstructions from a public morphology database, (2) 681 newly and manually reconstructed neurons, and (3) neurons reconstructions produced using several independent reconstruction methods. Our approach was able to accurately and efficiently retrieve morphologically and functionally similar neuron structures from large morphology database, identify the local common structures, and find clusters of neurons that share similarities in both morphology and molecular profiles.

  13. Exploration of the molecular basis of blast injury in a biofidelic model of traumatic brain injury

    Science.gov (United States)

    Thielen, P.; Mehoke, T.; Gleason, J.; Iwaskiw, A.; Paulson, J.; Merkle, A.; Wester, B.; Dymond, J.

    2018-01-01

    Biological response to blast overpressure is complex and results in various and potentially non-concomitant acute and long-term deficits to exposed individuals. Clinical links between blast severity and injury outcomes remain elusive and have yet to be fully described, resulting in a critical inability to develop associated protection and mitigation strategies. Further, experimental models frequently fail to reproduce observed physiological phenomena and/or introduce artifacts that confound analysis and reproducibility. New models are required that employ consistent mechanical inputs, scale with biological analogs and known clinical data, and permit high-throughput examination of biological responses for a range of environmental and battlefield- relevant exposures. Here we describe a novel, biofidelic headform capable of integrating complex biological samples for blast exposure studies. We additionally demonstrate its utility in detecting acute transcriptional responses in the model organism Caenorhabditis elegans after exposure to blast overpressure. This approach enables correlation between mechanical exposure and biological outcome, permitting both the enhancement of existing surrogate and computational models and the high-throughput biofidelic testing of current and future protection systems.

  14. DIRECT AIR BLAST EXPOSURE EFFECTS IN ANIMALS, OPERATION UPSHOT-KNOTHOLE, PROJECT 4.2

    Energy Technology Data Exchange (ETDEWEB)

    DRAEGER, R.H. (UNITED STATES NAVY - DEPARTMENT OF); LEE, R.H. (UNITED STATES NAVY - DEPARTMENT OF)

    1953-12-31

    tube. The agreement between the estimated pressures and the recorded pressures in the containers were good in some instances but not in others. Discounting the initial pressure rise, it was thought that the records represent the pressure changes in the exposure containers. The individual records exhibited rather wide variations in recorded pressures indicating a complex pressure field. The attempt to compare levels of direct air blast in small and large animals, and thereby to extrapolate to man, was not accomplished due to the lack of statistically reliable data on the dogs. The lapse of time between the death of the dogs and autopsy reduced the interpretable findings below the level required for statistical significance. Laboratory studies are planned to evaluate the relative importance of the several blast wave parameters in the production of injury, Recommendations for future field test studies will depend upon the outcome of this laboratory work.

  15. Acceleration from short-duration blast

    Science.gov (United States)

    Ritzel, D. V.; Van Albert, S.; Sajja, V.; Long, J.

    2018-01-01

    The blast-induced motion of spheres has been studied experimentally where the shock wave is rapidly decaying during the period that quasi-steady acceleration would be developed in the case of a step-function shock wave as considered in most shock-tube studies. The motion of sphere models ranging from 39 to 251 mm in diameter and having a range of densities was assessed using the "free-flight" method in a simulator specially designed to replicate the decaying shock wave profile of spherical blast including negative phase and positive entropy gradient. A standardized blast-wave simulation of 125 kPa and 6-ms positive-phase duration was applied for all experiments. In all cases, there are three phases to the motion: a relatively low "kickoff" velocity from the shock diffraction, acceleration or deceleration during the positive duration, then deceleration through the negative phase and subsequent quiescent air. The unexpected deceleration of larger spheres after their kickoff velocity during the decaying yet high-speed flow of the blast wave seems associated with the persistence of a ring vortex on the downstream side of the sphere. The flow is entirely unsteady with initial forces dominated by the shock diffraction; therefore, the early motion of spheres under such conditions is not governed by quasi-steady drag as in classical aerodynamics. The work will help establish scaling rules for model studies of blast-induced motion relevant to improvised explosive devices, and preliminary results are shown for motion imparted to a human skull surrogate.

  16. Mathematical model and software for control of commissioning blast furnace

    Science.gov (United States)

    Spirin, N. A.; Onorin, O. P.; Shchipanov, K. A.; Lavrov, V. V.

    2016-09-01

    Blowing-in is a starting period of blast furnace operation after construction or major repair. The current approximation methods of blowing-in burden analysis are based on blowing-in practice of previously commissioned blast furnaces. This area is theoretically underexplored; there are no common scientifically based methods for selection of the burden composition and blast parameters. The purpose of this paper is development and scientific substantiation of the methods for selection of the burden composition and blast parameters in the blast furnace during the blowing-in period. Research methods are based on physical regularities of main processes running in the blast furnace, system analysis, and application of modern principles for development and construction of mathematical models, algorithms and software designed for automated control of complex production processes in metallurgy. As consequence of the research made by the authors the following results have been achieved: 1. A set of mathematical models for analysis of burden arrangement throughout the height of the blast furnace and for selection of optimal blast and gas dynamic parameters has been developed. 2. General principles for selection of the blowing-in burden composition and blast and gas dynamic parameters have been set up. 3. The software for the engineering and process staff of the blast furnace has been developed and introduced in the industry.

  17. Aespoe HRL. Experiences of blasting of the TASQ tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, Mats [Swebrec, Luleaa (Sweden); Niklasson, Bengt [Skanska Teknik, Stockholm (Sweden); Wilson, Lasse [Skanska Stora Projekt, Stockholm (Sweden); Andersson, Christer; Christiansson, Rolf [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    2004-11-01

    A new tunnel was developed at the Aespoe Hard Rock Laboratory (AHRL) during the spring and summer 2003. The tunnel was specially designed for a rock mechanics experiment, the Aespoe Pillar Stability Experiment (APSE). In this pillar experiment there was a high demand to initiate high in-situ stresses and therefore the tunnel was designed with a large height/ width ratio and with a circular floor. There were high requirements on bore hole precision and of a minimized EDZ (Excavation damaged zone) in the pillar area. This included a maximum borehole deviation of 10 mm/m, a maximum overbreak due to the lookout angle of 0.3 m and an EDZ of 0.3 m. To make a charge control feasible cartridged explosives was prescribed. The initiation was made with Nonel. The last three rounds used electronic initiation to enable studies of possibility to further reduce the EDZ. The collar of the tunnel was very close to installations and shaft and it was very important to avoid fly-rock and vibrations. Special types of stemming were used as well as steel plates and rubber mats. The excavation works was divided in three different phases. The first phase of the tunnel was an ordinary 26 m{sup 2} tunnel. After approximately 30 m a ramp separated the tunnel section into a top heading and a bench, total 33 m{sup 2}. After the last top heading round was excavated and the roof had been reinforced with fibre reinforced shotcrete the bench was taken out with horizontal holes as the third phase. The drilling precision was very good and 95% of all half-pipes fulfilled the demands. The total amount of visible half-pipes in the APSE-tunnel was high and indicated a successful smooth blasting. The EDZ was examined further by cutting slots in the wall and roof. Existing cracks appear very clearly when a dye penetrant is sprayed on the cleaned surface. A typical crack pattern consists of blast cracks, induced cracks (cracks from the distressing caused by blasting) and natural cracks. The maximum crack

  18. BLAST Ring Image Generator (BRIG: simple prokaryote genome comparisons

    Directory of Open Access Journals (Sweden)

    Beatson Scott A

    2011-08-01

    Full Text Available Abstract Background Visualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are required in order to improve the validation, interpretation and communication of genome sequence information; especially with the increasing amount of data arising from next-generation sequencing projects. Visualising a prokaryote genome as a circular image has become a powerful means of displaying informative comparisons of one genome to a number of others. Several programs, imaging libraries and internet resources already exist for this purpose, however, most are either limited in the number of comparisons they can show, are unable to adequately utilise draft genome sequence data, or require a knowledge of command-line scripting for implementation. Currently, there is no freely available desktop application that enables users to rapidly visualise comparisons between hundreds of draft or complete genomes in a single image. Results BLAST Ring Image Generator (BRIG can generate images that show multiple prokaryote genome comparisons, without an arbitrary limit on the number of genomes compared. The output image shows similarity between a central reference sequence and other sequences as a set of concentric rings, where BLAST matches are coloured on a sliding scale indicating a defined percentage identity. Images can also include draft genome assembly information to show read coverage, assembly breakpoints and collapsed repeats. In addition, BRIG supports the mapping of unassembled sequencing reads against one or more central reference sequences. Many types of custom data and annotations can be shown using BRIG, making it a versatile approach for visualising a range of genomic comparison data. BRIG is readily accessible to any user, as it assumes no specialist computational knowledge and will perform all required file parsing and BLAST comparisons

  19. Full-scale testing and numerical modeling of a multistory masonry structure subjected to internal blast loading

    Science.gov (United States)

    Zapata, Brian Jarvis

    provided highly resolved spatio-temporal blast loading data for subsequent structural simulations. Equivalent single-degree-of-freedom (ESDOF) structural response models were then used to predict the out-of-plane deflections of blast chamber walls. A new resistance function was developed which permits a URM wall to crack at any height; numerical methodologies were also developed to compute transformation factors required for use in the ESDOF method. When combined with the CTH derived blast loading predictions, the ESDOF models were able to predict out-of-plane deflections with reasonable accuracy. Further investigations were performed using finite element models constructed in LS-DYNA; the models used elastic elements combined with contacts possessing a tension/shear cutoff and the ability to simulate fracture energy release. Using the CTH predicted blast loads and carefully selected constitutive parameters, the LS-DYNA models were able to both qualitatively and quantitatively predict blast chamber wall deflections and damage patterns. Moreover, the finite element models suggested several modes of response which cannot be modeled by current ESDOF methods; the effect of these response modes on the accuracy of ESDOF predictions warrants further study.

  20. Proceedings of the seventeenth annual conference on explosives and blasting technique. Volume 1

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Papers from this conference dealt with the following topics: surface and underground mine blasting, control of blast effects in sensitive areas, blasthole deviation, regulatory impact when blasting at Superfund sites, computer-aided blast design and monitoring, tunneling techniques, shaft excavations, video camera analysis of blasting operations, soil densification, cost optimization, mine blasting accidents, non-electric initiation systems, and delay detonators. Papers have been indexed separately for inclusion on the data base

  1. The Biological Basis of Chronic Traumatic Encephalopathy following Blast Injury: A Literature Review.

    Science.gov (United States)

    Aldag, Matt; Armstrong, Regina C; Bandak, Faris; Bellgowan, Patrick S F; Bentley, Timothy; Biggerstaff, Sean; Caravelli, Katrina; Cmarik, Joan; Crowder, Alicia; DeGraba, Thomas J; Dittmer, Travis A; Ellenbogen, Richard G; Greene, Colin; Gupta, Raj K; Hicks, Ramona; Hoffman, Stuart; Latta, Robert C; Leggieri, Michael J; Marion, Donald; Mazzoli, Robert; McCrea, Michael; O'Donnell, John; Packer, Mark; Petro, James B; Rasmussen, Todd E; Sammons-Jackson, Wendy; Shoge, Richard; Tepe, Victoria; Tremaine, Ladd A; Zheng, James

    2017-09-01

    The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury. It served to inform participants objectively and help focus meeting discussion on identifying knowledge gaps and priority research areas. CTE is described generally as a progressive neurodegenerative disorder affecting persons exposed to head injury. Affected individuals have been participants primarily in contact sports and military personnel, some of whom were exposed to blast. The symptomatology of CTE overlaps with Alzheimer's disease and includes neurological and cognitive deficits, psychiatric and behavioral problems, and dementia. There are no validated diagnostic criteria, and neuropathological evidence of CTE has come exclusively from autopsy examination of subjects with histories of exposure to head injury. The perivascular accumulation of hyperphosphorylated tau (p-tau) at the depths of cortical sulci is thought to be unique to CTE and has been proposed as a diagnostic requirement, although the contribution of p-tau and other reported pathologies to the development of clinical symptoms of CTE are unknown. The literature on CTE is limited and is focused predominantly on head injuries unrelated to blast exposure (e.g., football players and boxers). In addition, comparative analyses of clinical case reports has been challenging because of small case numbers, selection biases, methodological differences, and lack of matched controls, particularly for blast-exposed individuals. Consequently, the

  2. The use of vibration monitoring to record the blasting works impact on buildings surrounding open-pit mines

    Science.gov (United States)

    Sołtys, Anna; Pyra, Józef; Winzer, Jan

    2018-04-01

    Environmental protection law and geological and mining law require the mineral mining plant to protect its surroundings from the effects of mining operations. This also applies to the negative impact of vibrations induced by blasting works on people and construction facilities. Effective protection is only possible if the level of this impact is known, therefore it is necessary to record it. The thesis formulated in this way has been and continues to be the guiding principle of the research works carried out in the AGH Laboratory of Blasting Work and Environmental Protection. As a result of these works are procedures for conducting preventive activities by open-pit mines in order to minimize the impact of blasting on facilities in the surrounding area. An important element of this activity is the monitoring of vibrations in constructions, which is a source of knowledge for excavation supervisors and engineers performing blasting works, thus contributing to raising the awareness of the responsible operation of the mining plant. Developed in the Laboratory of the Mine's Vibration Monitoring Station (KSMD), after several modernizations, it became a fully automated system for monitoring and recording the impact of blasting works on the surrounding environment. Currently, there are 30 measuring devices in 10 open-pit mines, and additional 8 devices are used to provide periodic measurement and recording services for the mines concerned.

  3. The use of vibration monitoring to record the blasting works impact on buildings surrounding open-pit mines

    Directory of Open Access Journals (Sweden)

    Sołtys Anna

    2018-01-01

    Full Text Available Environmental protection law and geological and mining law require the mineral mining plant to protect its surroundings from the effects of mining operations. This also applies to the negative impact of vibrations induced by blasting works on people and construction facilities. Effective protection is only possible if the level of this impact is known, therefore it is necessary to record it. The thesis formulated in this way has been and continues to be the guiding principle of the research works carried out in the AGH Laboratory of Blasting Work and Environmental Protection. As a result of these works are procedures for conducting preventive activities by open-pit mines in order to minimize the impact of blasting on facilities in the surrounding area. An important element of this activity is the monitoring of vibrations in constructions, which is a source of knowledge for excavation supervisors and engineers performing blasting works, thus contributing to raising the awareness of the responsible operation of the mining plant. Developed in the Laboratory of the Mine's Vibration Monitoring Station (KSMD, after several modernizations, it became a fully automated system for monitoring and recording the impact of blasting works on the surrounding environment. Currently, there are 30 measuring devices in 10 open-pit mines, and additional 8 devices are used to provide periodic measurement and recording services for the mines concerned.

  4. Analysis of post-blasting source mechanisms of mining-induced seismic events in Rudna copper mine, Poland

    Directory of Open Access Journals (Sweden)

    Caputa Alicja

    2015-10-01

    Full Text Available The exploitation of georesources by underground mining can be responsible for seismic activity in areas considered aseismic. Since strong seismic events are connected with rockburst hazard, it is a continuous requirement to reduce seismic risk. One of the most effective methods to do so is blasting in potentially hazardous mining panels. In this way, small to moderate tremors are provoked and stress accumulation is substantially reduced. In this paper we present an analysis of post-blasting events using Full Moment Tensor (MT inversion at the Rudna mine, Poland, underground seismic network. In addition, we describe the problems we faced when analyzing seismic signals. Our studies show that focal mechanisms for events that occurred after blasts exhibit common features in the MT solution. The strong isotropic and small Double Couple (DC component of the MT, indicate that these events were provoked by detonations. On the other hand, post-blasting MT is considerably different than the MT obtained for strong mining events. We believe that seismological analysis of provoked and unprovoked events can be a very useful tool in confirming the effectiveness of blasting in seismic hazard reduction in mining areas.

  5. Decreased sensitivity of the automatic white precursor cell channel (WPC) for blast flagging in patients with leukopenia.

    Science.gov (United States)

    Lee, Nuri; Jun, Ju Hyun; Lee, Dong Soon

    2016-06-01

    The advantage of Sysmex XN system is its performance of an automatic reflex test in white cell precursor (WPC) channel, which gives an accurate differential count. We performed a real-time evaluation of the automatic differential count according to WBC number with Sysmex XN series and demonstrated a significant differential impact on blast distinction depending on the number of WBC. We categorized the 49,699 specimen according to WBC number and compared the results of blast flagging in the white cell differential (WDF) channel and WPC channel on the basis of the results of manual differential count. Additionally, clinical impact of missed blasts after running WPC reflex test was analyzed. For patients with WBC under 1.5×10(9)/L, blast flagging for WPC channel showed markedly decreased sensitivity (56%) compared to that of WDF mode (100%). Most of the patients with missed blasts in WPC mode were under chemotherapy or hematopoietic stem cell transplantation. The specificity and efficiency for WPC channel were much higher than that of WDF mode in all range of WBC. Considering the additional reagent cost required for the WPC channel, WPC reflex test is not suitable for patients with leukopenia if it is operated alone. Instead, manual blood film review or double-check with other supplemental equipment should be accompanied. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  6. A Feasibility Study for Recycling Used Automotive Oil Filters In A Blast Furnace

    Energy Technology Data Exchange (ETDEWEB)

    Ralph M. Smailer; Gregory L. Dressel; Jennifer Hsu Hill

    2002-01-21

    This feasibility study has indicated that of the approximately 120,000 tons of steel available to be recycled from used oil filters (UOF's), a maximum blast furnace charge of 2% of the burden may be anticipated for short term use of a few months. The oil contained in the most readily processed UOF's being properly hot drained and crushed is approximately 12% to 14% by weight. This oil will be pyrolized at a rate of 98% resulting in additional fuel gas of 68% and a condensable hydrocarbon fraction of 30%, with the remaining 2% resulting as carbon being added into the burden. Based upon the writer's collected information and assessment, there appears to be no operational problems relating to the recycling of UOF's to the blast furnace. One steel plant in the US has been routinely charging UOF's at about 100 tons to 200 tons per month for many years. Extensive analysis and calculations appear to indicate no toxic consideration as a result of the pyrolysis of the small contained oil ( in the 'prepared' UOFs) within the blast furnace. However, a hydrocarbon condensate in the ''gasoline'' fraction will condense in the blast furnace scrubber water and may require additional processing the water treatment system to remove benzene and toluene from the condensate. Used oil filters represent an additional source of high quality iron units that may be effectively added to the charge of a blast furnace for beneficial value to the operator and to the removal of this resource from landfills.

  7. Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae

    Directory of Open Access Journals (Sweden)

    Deng Jixin

    2009-02-01

    Full Text Available Abstract Background Magnaporthe oryzae, the causal agent of blast disease of rice, is the most destructive disease of rice worldwide. The genome of this fungal pathogen has been sequenced and an automated annotation has recently been updated to Version 6 http://www.broad.mit.edu/annotation/genome/magnaporthe_grisea/MultiDownloads.html. However, a comprehensive manual curation remains to be performed. Gene Ontology (GO annotation is a valuable means of assigning functional information using standardized vocabulary. We report an overview of the GO annotation for Version 5 of M. oryzae genome assembly. Methods A similarity-based (i.e., computational GO annotation with manual review was conducted, which was then integrated with a literature-based GO annotation with computational assistance. For similarity-based GO annotation a stringent reciprocal best hits method was used to identify similarity between predicted proteins of M. oryzae and GO proteins from multiple organisms with published associations to GO terms. Significant alignment pairs were manually reviewed. Functional assignments were further cross-validated with manually reviewed data, conserved domains, or data determined by wet lab experiments. Additionally, biological appropriateness of the functional assignments was manually checked. Results In total, 6,286 proteins received GO term assignment via the homology-based annotation, including 2,870 hypothetical proteins. Literature-based experimental evidence, such as microarray, MPSS, T-DNA insertion mutation, or gene knockout mutation, resulted in 2,810 proteins being annotated with GO terms. Of these, 1,673 proteins were annotated with new terms developed for Plant-Associated Microbe Gene Ontology (PAMGO. In addition, 67 experiment-determined secreted proteins were annotated with PAMGO terms. Integration of the two data sets resulted in 7,412 proteins (57% being annotated with 1,957 distinct and specific GO terms. Unannotated proteins

  8. Database indexing for production MegaBLAST searches.

    Science.gov (United States)

    Morgulis, Aleksandr; Coulouris, George; Raytselis, Yan; Madden, Thomas L; Agarwala, Richa; Schäffer, Alejandro A

    2008-08-15

    The BLAST software package for sequence comparison speeds up homology search by preprocessing a query sequence into a lookup table. Numerous research studies have suggested that preprocessing the database instead would give better performance. However, production usage of sequence comparison methods that preprocess the database has been limited to programs such as BLAT and SSAHA that are designed to find matches when query and database subsequences are highly similar. We developed a new version of the MegaBLAST module of BLAST that does the initial phase of finding short seeds for matches by searching a database index. We also developed a program makembindex that preprocesses the database into a data structure for rapid seed searching. We show that the new 'indexed MegaBLAST' is faster than the 'non-indexed' version for most practical uses. We show that indexed MegaBLAST is faster than miBLAST, another implementation of BLAST nucleotide searching with a preprocessed database, for most of the 200 queries we tested. To deploy indexed MegaBLAST as part of NCBI'sWeb BLAST service, the storage of databases and the queueing mechanism were modified, so that some machines are now dedicated to serving queries for a specific database. The response time for such Web queries is now faster than it was when each computer handled queries for multiple databases. The code for indexed MegaBLAST is part of the blastn program in the NCBI C++ toolkit. The preprocessor program makembindex is also in the toolkit. Indexed MegaBLAST has been used in production on NCBI's Web BLAST service to search one version of the human and mouse genomes since October 2007. The Linux command-line executables for blastn and makembindex, documentation, and some query sets used to carry out the tests described below are available in the directory: ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/indexed_megablast [corrected] Supplementary data are available at Bioinformatics online.

  9. Gene interactions and genetics of blast resistance and yield

    Indian Academy of Sciences (India)

    Blast disease caused by the pathogen Pyricularia oryzae is a serious threat to rice production. Six generations viz., P1, P2, F1, F2, B1 and B2 of a cross between blast susceptible high-yielding rice cultivar ADT 43 and resistant near isogenic line (NIL) CT13432-3R, carrying four blast resistance genes Pi1, Pi2, Pi33 and Pi54 ...

  10. The Pre-Blast Concept for use on Armour Materials

    Science.gov (United States)

    2016-02-01

    UNCLASSIFIED UNCLASSIFIED The Pre-Blast Concept for use on Armour Materials C. Choi1, C. Peng2 and B. Dixon1 1Land Division Defence...to improve blast resistance Repeated blast test results (up to 7 times) of candidate armour materials showed that the greatest deformation...evidence of cracking in the armour steels and Crack-starter explosion bulge testing of the armour steels at -18 ºC demonstrated that the steels have

  11. Identification and detection of murine leukemia blasts by flow cytometry

    OpenAIRE

    sprotocols

    2015-01-01

    Human leukemia has been determined and classified with the help of flow cytometry for the past two decades. Past attempts to detect leukemia blasts relied on both forward and side scatter (FSC and SSC) based on cell size and granularity. However, this technique failed to show a clean separation of blasts from normal lineage cells. In 1993, Borowitz, et al developed flow cytometric analysis to distinguish human leukemia blasts from other normal lineage cells by using fluorescence-conjugated CD...

  12. 75 FR 29404 - Contract Reporting Requirements of Intrastate Natural Gas Companies

    Science.gov (United States)

    2010-05-26

    ... Analysis 109 X. Regulatory Flexibility Act 110 XI. Document Availability 112 XII. Effective Date and... less stringent transactional reporting requirements for NGPA section 311 intrastate pipelines and... transactional reporting requirements for intrastate and Hinshaw pipelines in order to increase market...

  13. Proceedings of the eighteenth annual conference on explosives and blasting technique

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    This edition of the Proceedings of the Annual Conference on Explosives and Blasting Techniques is the eighteenth in a series published by the International Society of Explosives Engineers. The papers cover a wide variety of explosives and blasting techniques, including: rock mechanics, rock drilling, perimeter control handling and documenting blasting complaints, blast vibration frequencies, blasting techniques for surface and underground coal mines, explosives for permafrost blasting, lightning detection, use of slow motion video to analyze blasts, tunneling, and close-in blasting control. Papers have been processed individually for inclusion on the data base

  14. WU-Blast2 server at the European Bioinformatics Institute

    Science.gov (United States)

    Lopez, Rodrigo; Silventoinen, Ville; Robinson, Stephen; Kibria, Asif; Gish, Warren

    2003-01-01

    Since 1995, the WU-BLAST programs (http://blast.wustl.edu) have provided a fast, flexible and reliable method for similarity searching of biological sequence databases. The software is in use at many locales and web sites. The European Bioinformatics Institute's WU-Blast2 (http://www.ebi.ac.uk/blast2/) server has been providing free access to these search services since 1997 and today supports many features that both enhance the usability and expand on the scope of the software. PMID:12824421

  15. Analysis of the flexible receiver lifting yoke and blast shield assembly. Tank 241SY101

    International Nuclear Information System (INIS)

    Huang, F.H.

    1995-01-01

    The analysis of the lifting yoke and blast shield assembly considers the bending stress, weld strength, and resistance of the lug hole to tear out. The bending stress of the lifting lugs is evaluated to ensure that they meet the requirements of the American Institute for Steel Construction (AISC 1989). Also considered in the calculations is the capability of the thick lugs to withstand the weight of the pump together with that of the container and strongback during rotation to the horizontal position

  16. Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

    Science.gov (United States)

    2015-11-01

    altering input pressures or distance from the eye. Use of this model produced some of the changes noted in IED blast warriors 6 . We will use the eye...determine if the protective actions of Compound 49b involve insulin -like growth factor binding protein-3 (IGFBP-3) pathways, as we have shown this to be...used by most investigators without the requirement for retrograde labeling that may alter the physiology of RGCs. Our protocol also does not include

  17. Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to ‘composite’ blast.

    Directory of Open Access Journals (Sweden)

    Stanislav I. Svetlov

    2012-02-01

    Full Text Available A number of experimental models of blast brain injury have been implemented in rodents and larger animals. However, the variety of blast sources and the complexity of blast wave biophysics have made data on injury mechanisms and biomarkers difficult to analyze and compare. Recently, we showed the importance of rat position towards blast generated by an external shock tube. In this study, we further characterized blast producing moderate TBI and defined ‘composite’ blast and primary blast exposure set-ups. Schlieren optics visualized interaction between the head and a shock wave generated by external shock tube, revealing strong head acceleration upon positioning the rat on-axis with the shock tube (composite blast, but negligible skull movement upon peak overpressure exposure off-axis (primary blast. Brain injury signatures of a primary blast hitting the frontal head were assessed and compared to damage produced by composite blast. Low to negligible levels of neurodegeneration were found following primary blast compared to composite blast by silver staining. However, persistent gliosis in hippocampus and accumulation of GFAP/CNPase in circulation was detected after both primary and composite blast. Also, markers of vascular/endothelial inflammation integrin alpha/beta, sICAM, and L-selectin along with neurotrophic factor NGF-beta were increased in serum within 6 hours post-blasts and persisted for 7 days thereafter. In contrast, systemic IL-1, IL-10, fractalkine, neuroendocrine peptide Orexin A, and VEGF receptor Neuropilin-2 (NRP-2 were raised predominantly after primary blast exposure. In conclusion, biomarkers of major pathological pathways were elevated at all blast setups. The most significant and persistent changes in neuro-glial markers were found after composite blast, while primary blast instigated prominent systemic cytokine/chemokine, Orexin A, and Neuropilin-2 release, particularly when primary blast impacted rats with

  18. Efforts and Programs of the Department of Defense Relating to the Prevention, Mitigation, and Treatment of Blast Injuries

    Science.gov (United States)

    2007-01-01

    proposed. The hybrid constructs consist of a titanium core surrounded by bioengineered enamel, dentin, cementum, and importantly, periodontal ligament...therapy into patients requiring reconstructive surgery of limbs or tissues damaged in the battlefield or for patients with vascular disease in need...Evaluation • Protection – Environmental Injury Models: Model the effects of inhaled toxic gases, including smoke and aerosols, associated with blast

  19. A Phased Array Approach to Rock Blasting

    Energy Technology Data Exchange (ETDEWEB)

    Leslie Gertsch; Jason Baird

    2006-07-01

    A series of laboratory-scale simultaneous two-hole shots was performed in a rock simulant (mortar) to record the shock wave interference patterns produced in the material. The purpose of the project as a whole was to evaluate the usefulness of phased array techniques of blast design, using new high-precision delay technology. Despite high-speed photography, however, we were unable to detect the passage of the shock waves through the samples to determine how well they matched the expected interaction geometry. The follow-up mine-scale tests were therefore not conducted. Nevertheless, pattern analysis of the vectors that would be formed by positive interference of the shockwaves from multiple charges in an ideal continuous, homogeneous, isotropic medium indicate the potential for powerful control of blast design, given precise characterization of the target rock mass.

  20. Panicle blast 1 (Pb1) resistance is dependent on at least four QTLs in the rice genome.

    Science.gov (United States)

    Inoue, Haruhiko; Nakamura, Mitsuru; Mizubayashi, Tatsumi; Takahashi, Akira; Sugano, Shoji; Fukuoka, Shuuichi; Hayashi, Nagao

    2017-12-01

    Rice blast is the most serious disease afflicting rice and there is an urgent need for the use of disease resistance (R) genes in blast tolerance breeding programs. Pb1 is classified as a quantitative resistance gene and it does not have fungal specificity. Pb1-mediated resistance develops in the latter stages of growth. However, some cultivars, such as Kanto209 (K209), cultivar name Satojiman, despite possessing Pb1, do not exert resistance to rice blast during the reproductive stage. We found that the expression of WRKY45 gene downstream of Pb1 was weakly induced by rice blast inoculation at the full heading stage in K209. Genetic analysis using the SNP-based Golden Gate assay of K209 crossing with Koshihikari Aichi SBL (KASBL) found at least four regions related to the resistance in the rice genome (Chr8, Chr9, Chr7, Chr11). Mapping of QTL related to Chr7 confirmed the existence of factors that were required for the resistance of Pb1 in the 22 to 23 Mbp region of the rice genome. We clarified how the K209 cultivar is vulnerable to the blast disease despite possessing Pb1 and found the DNA marker responsible for the quantitative resistance of Pb1. We identified the QTL loci required for Pb1-mediated resistance to rice panicle blast. Pb1 was negatively dependent on at least three QTLs, 7, 9 and 11, and positively dependent on one, QTL 8, in the K209 genome. This finding paves the way for creating a line to select optimal QTLs in order to make use of Pb1-mediated resistance more effectively.

  1. Plastic Media Blasting Data Gathering Study

    Science.gov (United States)

    1986-12-01

    matt, reducing the filtering surface. 25 3) Cartridge Collectors: Cartridge dust collectors consist of a number of nonwoven tubular filters placed...by up to 90 percent. This task gathered data in five areas: chemical stripping, equipment and facilities, economics, safety and health , and surface...analyses conducted for the blast booth at Hill Air Force Base. The Safety section discusses the safety and health risks associated with PMB such as

  2. Blast Performance of Four Armour Materials

    Science.gov (United States)

    2013-08-01

    Charpy V- notch impact toughness results, as well as the highest carbon content of the steels tested . 5. For all steels the greatest deformation...Explosion Bulge Test (EBT). A number of conclusions may be drawn from these investigations and are summarised as follows: All steels tested were...good toughness and greater ductility, but less hardness. Multiple blast testing showed that steel A and steel M possessed the best resistance to

  3. Blast Injuries: What Clinicians Need to Know

    Centers for Disease Control (CDC) Podcasts

    2008-11-05

    In this podcast, Dr. Richard C. Hunt, Director of the CDC’s Division of Injury Response, National Center for Injury Prevention and Control provides a brief overview for health care providers on how to respond and care for persons injured by an explosion or blast event.  Created: 11/5/2008 by National Center for Injury Prevention and Control (NCIPC), Division of Injury Response (DIR).   Date Released: 11/6/2008.

  4. Centrifugal shot blasting. Innovative technology summary report

    International Nuclear Information System (INIS)

    1999-07-01

    At the US Department of Energy (DOE) Fernald Environmental Management Project (FEMP), the Facilities Closure and Demolition Projects Integrated Remedial Design/Remedial Action (RD/RA) work plan calls for the removal of one inch (1 in) depth of concrete surface in areas where contamination with technetium-99 has been identified. This report describes a comparative demonstration between two concrete removal technologies: an innovative system using Centrifugal Shot Blasting (CSB) and a modified baseline technology called a rotary drum planer

  5. Advanced MRI in Blast-related TBI

    Science.gov (United States)

    2012-07-01

    this study possible; the staff at the LRMC MRI clinic, including Don Al- brant, Kenny Caywood, Kelly McKay, Tim McKay, Tim Roberts, Kris Robertson...erans with persistent post-concussive symp- toms . Neuroimage 2011;54:Suppl 1:S76- S82. 12. Warden DL, French LM, Shupenko L, et al. Case report of a...Luethcke CA, Bryan CJ, Morrow CE, Isler WC. Comparison of concussive symp- toms , cognitive performance, and psycho- logical symptoms between acute blast

  6. Legal status and source of offenders' firearms in states with the least stringent criteria for gun ownership.

    Science.gov (United States)

    Vittes, Katherine A; Vernick, Jon S; Webster, Daniel W

    2013-02-01

    Gun possession by high-risk individuals presents a serious threat to public safety. U.S. federal law establishes minimum criteria for legal purchase and possession of firearms; many states have laws disqualifying additional categories for illegal possession. We used data from a national survey of state prison inmates to calculate: 1) the proportion of offenders, incarcerated for crimes committed with firearms in 13 states with the least restrictive firearm purchase and possession laws, who would have been prohibited if their states had stricter gun laws; and 2) the source of gun acquisition for offenders who were and were not legally permitted to purchase and possess firearms. Nearly three of ten gun offenders (73 of 253 or 28.9%) were legal gun possessors but would have been prohibited from purchasing or possessing firearms when committing their most recent offense if their states had stricter prohibitions. Offenders who were already prohibited under current law acquired their gun from a licensed dealer, where a background check is required, five times less often than offenders who were not prohibited (3.9% vs. 19.9%; χ(2)=13.31; p≤0.001). Nearly all (96.1%) offenders who were legally prohibited, acquired their gun from a supplier not required to conduct a background check. Stricter gun ownership laws would have made firearm possession illegal for many state prison inmates who used a gun to commit a crime. Requiring all gun sales to be subject to a background check would make it more difficult for these offenders to obtain guns.

  7. Blast furnace hearth lining: post mortem analysis

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Bruno Vidal de; Vernilli Junior, Fernando, E-mail: bva@usp.br [Universidade de Sao Paulo (USP), Lorena, SP (Brazil). Escola de Engenharia; Neves; Elton Silva; Silva, Sidiney Nascimento [Companhia Siderugica Nacional (CSN), Rio de Janeiro, RJ (Brazil)

    2017-05-15

    The main refractory lining of blast furnace hearth is composed by carbon blocks that operates in continuous contact with hot gases, liquid slag and hot metal, in temperatures above 1550 deg C for 24 hours a day. To fully understand the wear mechanism that acts in this refractory layer system it was performed a Post Mortem study during the last partial repair of this furnace. The samples were collected from different parts of the hearth lining and characterized using the following techniques: Bulk Density and Apparent Porosity, X-Ray Fluorescence, X-ray Diffraction, Scanning Electron Microscopy with Energy-dispersive X-Ray Spectroscopy. The results showed that the carbon blocks located at the opposite side of the blast furnace tap hole kept its main physicochemical characteristics preserved even after the production of 20x10{sup 6} ton of hot metal. However, the carbon blocks around the Tap Hole showed infiltration by hot metal and slag and it presents a severe deposition of zinc and sulfur over its carbon flakes. The presence of these elements is undesired because it reduces the physic-chemical stability of this refractory system. This deposition found in the carbon refractory is associated with impurities present in the both coke and the sinter feed used in this blast furnace in the last few years. (author)

  8. Multiphase blast interaction between heterogeneous explosives

    Science.gov (United States)

    Ripley, Robert; Ryan, Sydney; Jenkins, Charles M.

    2017-06-01

    Spherical charges loaded with micrometric metal powders feature explosively dispersed particle fields. The interaction phenomena of opposing multiphase flow fields from multiple charges depend on the charge spacing, loading configuration and particle morphology. For identical heterogeneous charges with a separation distance in the near field, the multiphase blast interaction includes particle-particle collision in the shocked air and impinging detonation products between the charges. Experiments recorded using high-speed framing cameras show the blast interaction process and resolve details of the multiphase structures. Hydrocode simulations are conducted using inelastic Lagrangian particle groups with a Direct Simulation Monte Carlo particle collision model. The numerical results distinguish the multiphase interaction layer and gas dynamic boundaries, with an emphasis on the particle laden Mach stem. The experimental results provide data for comparison to the interacting front velocities and Mach stem velocity. Modeling results for twin charges are shown to be different from a single heterogeneous blast reflection due to the stochastic and dissipative particle collisions. Remaining differences between the experimental and numerical results are discussed. The numerical results are further analyzed to assess particle fragmentation and potential for enhanced reaction in the interaction region between heterogeneous charges. DISTRIBUTION A. Approved for public release; distribution is unlimited. 96TW-2017-0079.

  9. Verification of wet blasting decontamination technology

    International Nuclear Information System (INIS)

    Matsubara, Sachito; Murayama, Kazunari; Yoshida, Hirohisa; Igei, Shigemitsu; Izumida, Tatsuo

    2013-01-01

    Macoho Co., Ltd. participated in the projects of 'Decontamination Verification Test FY 2011 by the Ministry of the Environment' and 'Decontamination Verification Test FY 2011 by the Cabinet Office.' And we tested verification to use a wet blasting technology for decontamination of rubble and roads contaminated by the accident of Fukushima Daiichi Nuclear Power Plant of the Tokyo Electric Power Company. As a results of the verification test, the wet blasting decontamination technology showed that a decontamination rate became 60-80% for concrete paving, interlocking, dense-grated asphalt pavement when applied to the decontamination of the road. When it was applied to rubble decontamination, a decontamination rate was 50-60% for gravel and approximately 90% for concrete and wood. It was thought that Cs-134 and Cs-137 attached to the fine sludge scraped off from a decontamination object and the sludge was found to be separated from abrasives by wet cyclene classification: the activity concentration of the abrasives is 1/30 or less than the sludge. The result shows that the abrasives can be reused without problems when the wet blasting decontamination technology is used. (author)

  10. Blast Wave Mitigation in Granular Materials

    Science.gov (United States)

    Pontalier, Quentin; Lhoumeau, Maxime; Frost, David

    2017-06-01

    A common technique to mitigate the blast wave from a high explosive is to surround the explosive with a layer of inert particles or liquid. In the case of a powder layer in spherical geometry, the spherically expanding shock wave that propagates first within the porous powder bed has a complex structure and induces the formation of force chains through particles in contact, shock propagation in the interstitial gas, and leads to shock compaction and deformation of the particle bed. Overall, the shock accelerates the particles and heats the gas in the pores and the partition of the total energy between kinetic and internal energy is primarily a function of the layer porosity and mass ratio of material to explosive. This energy partition is explored computationally with a multiphase hydrocode as a function of the bed parameters and compared with the case of a homogeneous liquid. The results are compared with experiments which track the strength of the blast wave emerging from the material layer as well as the material velocity using high-speed photography. For a given mass ratio, the strength of the blast wave transmitted into the air and the material velocity are significantly lower for particle beds than liquid layers due to energy dissipation during compaction of the bed.

  11. Numerical Investigation of Structural Response of Corrugated Blast Wall Depending on Blast Load Pulse Shapes

    Directory of Open Access Journals (Sweden)

    Jung Min Sohn

    Full Text Available Abstract Hydrocarbon explosions are one of most hazardous events for workers on offshore platforms. To protect structures against explosion loads, corrugated blast walls are typically installed. However, the profiles of real explosion loads are quite different depending on the congestion and confinement of Topside structures. As the level of congestion and confinement increases, the explosion load increases by up to 8 bar, and the rising time of the load decreases. This study primarily aims to investigate the structural behavior characteristics of corrugated blast walls under different types of explosion loadings. Four loading shapes were applied in the structural response analysis, which utilized a dynamic nonlinear finite element method.

  12. Cosmic Blasts Much More Common, Astronomers Discover

    Science.gov (United States)

    2006-08-01

    explosions is that the blasts that produce gamma rays and X-rays have disks of material rotating rapidly about the central object," Soderberg said. The powerful gamma ray bursts tap the tremendous gravitational energy of their black hole to produce strong beams of energetic radiation, while less-energetic X-ray bursts like the Feburary event tap energy from the strong magnetic field of the magnetar, the scientists speculated. "This discovery means that the 'zoo' of cosmic explosions has just gotten more numerous and more diverse. It also means that our understanding of how the cores of massive stars collapse to produce this variety of explosions is less complete than we had thought," Frail added. Multiwavelength follow-up observations were required by the team to measure the total energy release of the explosion. In particular, Soderberg adds that "Radio observations with the Very Large Array were additionally required to determine the geometry of the ejecta. We find that unlike typical GRBs which produce pencil-beam jets, this object more resembles a spherical explosion." In addition to Soderberg and Frail, the research team includes Shri Kulkarni. Ehud Nakar, Edo Berger, Brian Cameron, Avishay Gal-Yam, Re'em Sari, Mansi Kasiwal, Eran Ofek, Arne Rau, Brad Cenko, Eric Persson and Dae-Sik Moon of Caltech, Derrick Fox and Dave Burrows of Pennsylvania State University, Roger Chevalier of the University of Virginia, Tsvi Piran of the Hebrew University, Paul Price of the University of Hawaii, Brian Schmidt of Mount Stromlo Observatory in Australia, Guy Pooley of the Mullard Radio Astronomy Observatory in the UK, Bryan Penprase of Pomona College, and Neil Gehrels of the NASA Goddard Space Flight Center. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  13. Blast mines: physics, injury mechanisms and vehicle protection.

    Science.gov (United States)

    Ramasamy, A; Hill, A M; Hepper, A E; Bull, A M J; Clasper, J C

    2009-12-01

    Since World War II, more vehicles have been lost to land mines than all other threats combined. Anti-vehicular (AV) mines are capable of disabling a heavy vehicle, or completely destroying a lighter vehicle. The most common form of AV mine is the blast mine, which uses a large amount of explosive to directly damage the target. In a conventional military setting, landmines are used as a defensive force-multiplier and to restrict the movements of the opposing force. They are relatively cheap to purchase and easy to acquire, hence landmines are also potent weapons in the insurgents' armamentarium. The stand-offnature of its design has allowed insurgents to cause significant injuries to security forces in current conflicts with little personal risk. As a result, AV mines and improvised explosive devices (IEDs) have become the most common cause of death and injury to Coalition and local security forces operating in Iraq and Afghanistan. Detonation of an AV mine causes an explosive, exothermic reaction which results in the formation of a shockwave followed by a rapid expansion of gases. The shockwave is mainly reflected by the soillair interface and fractures the soil cap overthe mine. The detonation products then vent through the voids in the soil, resulting in a hollow inverse cone which consists of the detonation gases surrounded by the soil ejecta. It is the combination of the detonation products and soil ejecta that interact with the target vehicle and cause injury to the vehicle occupants. A number of different strategies are required to mitigate the blast effects of an explosion. Primary blast effects can be reduced by increasing the standoff distance between the seat of the explosion and the crew compartment. Enhancement of armour on the base of the vehicle, as well as improvements in personal protection can prevent penetration of fragments. Mitigating tertiary effects can be achieved by altering the vehicle geometry and structure, increasing vehicle mass, as

  14. Studies on induction of blast-resistant mutation in rice

    International Nuclear Information System (INIS)

    Tanaka, Sachihiko; Kawai, Takeshi; Yamasaki, Yoshito; Niizeki, Hiroo; Kiyosawa, Shigehisa.

    1980-01-01

    The mutation frequency of blast resistance in rice and that of increased pathogenicity of blast fungi were examined, using the rice variety, Norin 8, which is susceptible to all races of blast fungi in Japan, and a fungus strain, Ina 168, which carries 6 virulent genes, respectively. Four different inoculation methods were employed for screening blast resistant mutants, i.e., spraying spore suspensions in growth chambers, in a greenhouse and in a field nursery, and injecting spore suspensions into newly developed tillers. The number of lesions and their types were used as the criteria of blast resistance. For screening the fungus mutants with increased pathogenicity, the spore suspensions of the fungi to be tested were sprayed on the seedlings of the blast resistant varieties, and when susceptible-type lesions were formed, single spores were isolated from these lesions, and the change in its pathogenicity was confirmed. When seeds were irradiated with gamma ray and treated with chemicals (EMS or EI), the frequency of the mutants with high resistance to blast was 5/4,575 and 4/5,851 respectively, in the M 2 generation. The frequency of dominant blast resistant mutations following gamma-ray irradiation at the pre-embryo stage of growing plants was 3/60,101 in the M 1 generation. When the spore suspensions of blast fungi were treated with X-ray, the frequency of the mutants with increased pathogenicity was about 0.5%. Thus, the mutants highly resistant against blast of rice induced by radiation or chemicals would eventually become susceptible varieties because blast fungus mutants occurred more frequently with increased pathogenicity. (Kaihara, S.)

  15. Early clearance of peripheral blasts measured by flow cytometry during the first week of AML induction therapy as a new independent prognostic factor: a GOELAMS study.

    Science.gov (United States)

    Lacombe, F; Arnoulet, C; Maynadié, M; Lippert, E; Luquet, I; Pigneux, A; Vey, N; Casasnovas, O; Witz, F; Béné, M C

    2009-02-01

    An early appreciation of treatment efficacy could be very useful in acute myeloblastic leukemia (AML), and a prognostic value has been suggested for the morphological assessment of decrease in blasts during induction therapy. More sensitive, multiparametric flow cytometry (FCM) can detect far lower blast counts, allowing for a precise and reliable calculation of blast cell decrease rate (BDR). Such a multiparametric FCM four-colours/single-tube protocol, combining CD11b, CD45-ECD and CD16-PC5, was applied to peripheral blood samples from 130 AML patients, collected daily during induction chemotherapy. Normalized blast cell percentages were used to calculate the relevant decrease slopes. Slope thresholds (-15), or the time required to reach 90% depletion of the peripheral blast load (5 days), was strongly associated with the achievement of complete remission (P<0.0001). Log-rank test and Cox model showed that they also carried high statistical significance (P<0.0001) for disease-free survival. The prognostic value of cytogenetic features, confirmed in this series, was refined by BDR, which allowed to discriminate between good- and poor-risk patients among those with intermediate or normal karyotypes. This simple FCM protocol allows for an accurate prognostic sequential approach adapted to the determination of decrease in peripheral blast cells during induction chemotherapy.

  16. Blast injury ear in a low intensity conflict.

    Science.gov (United States)

    Kakkar, A

    2001-07-01

    The Eardrum is the most sensitive organ involved i blast injury and can be ruptured at relatively low pressure differentials. This study presents 200 cases of traumatic perforation among service personnel involved in a low intensity conflict, treated in a forward zonal hospital. Most blast injuries of the tympanic membrane (TM) heal spontaneously with conservative treatment (83%).

  17. Blast injury ear in a low intensity conflict

    OpenAIRE

    Kakkar, Anil

    2001-01-01

    The Eardrum is the most sensitive organ involved i blast injury and can be ruptured at relatively low pressure differentials. This study presents 200 cases of traumatic perforation among service personnel involved in a low intensity conflict, treated in a forward zonal hospital. Most blast injuries of the tympanic membrane (TM) heal spontaneously with conservative treatment (83%).

  18. Accidental hand grenade blast injuries in the Transkei region of ...

    African Journals Online (AJOL)

    The result is extensive mutilation of the body, particularly to those close to the blast. In this report the nature and .... Those who joined the liberation movements received training in firearms both within and outside the ... peak overpressures and positive-phase durations of blast waves.7 The simulated peak overpressure and ...

  19. Measurement and Modelling of Blast Movement to Reduce Ore ...

    African Journals Online (AJOL)

    This paper describes the application of the latest measurements and modelling techniques in understanding the blast dynamics and develops site specific solutions to minimise blast induced dilution and ore losses. These solutions are validated at Newmont Ahafo open pit mine through systematic trials and subsequently ...

  20. Gene interactions and genetics of blast resistance and yield ...

    Indian Academy of Sciences (India)

    2014-08-11

    Aug 11, 2014 ... Keywords. blast; gene action; generation mean analysis; resistance; yield. Journal of Genetics, Vol. 93, No. .... Utilizing the variance of different generations, the variances of A, B, C and D scales were ...... Jia Y. 2003 Marker assisted selection for the control of rice blast disease. Pesticide Outlook 14 ...

  1. Methodology of Testing Shot Blasting Machines in Industrial Conditions

    Directory of Open Access Journals (Sweden)

    R. Wrona

    2012-04-01

    Full Text Available Shot blasting machines are widely used for automated surface treatment and finishing of castings. In shot blasting processes the stream of shots is generated and shaped by blasting turbines, making up a kinetic and dynamic system comprising a separating rotor, an adapting sleeve and a propelling rotor provided with blades. The shot blasting performance- i.e. the quality of shot treated surfaces depends on the actual design and operational parameters of the unit whilst the values of relevant parameters are associated with the geometry of turbine components and the level of its integration with the separator system. The circulation of the blasting medium becomes the integrating factor of the process line, starting from the hopper, through the propeller turbine, casting treatment, separation of contaminated abrasive mixture, to its recycling and reuse.Inferior quality of the abrasive agent (shot and insufficient purity of the abrasive mixture are responsible for low effectiveness of shot blasting. However, most practitioners fail to fully recognise the importance of proper diagnostics of the shot blasting process in industrial conditions. The wearing of major machine components and of the blasting agent and quality of shot treated surfaces are often misinterpreted, hence the need to take into account all factors involved in the process within the frame of a comprehensive methodology.This paper is an attempt to formulate and apply the available testing methods to the engineering practice in industrial conditions.

  2. Delineating rockmass damage zones in blasting from in-field ...

    African Journals Online (AJOL)

    Delineating rockmass damage zones in blasting from in-field seismic velocity and peak particle velocity measurement. ... has been found that the integrity of rockmass is reduced significantly from pre to post blast condition due to disregard paid to the surrounding rockmass. For exercising suitable engineering controls ...

  3. Testing the blast wave model with Swift GRBs

    NARCIS (Netherlands)

    Curran, P.A.; Starling, R.L.C.; van der Horst, A.J.; Wijers, R.A.M.J.

    2009-01-01

    The complex structure of the light curves of Swift Gamma-Ray Bursts (GRBs) has made the identification of breaks, and the interpretation of the blast wave caused by the burst, more difficult than in the pre-Swift era. We aim to identify breaks, which are possibly hidden, and to constrain the blast

  4. Testing the blast wave model with Swift GRBs

    NARCIS (Netherlands)

    Curran, P.A.; Starling, R.L.C.; van der Horst, A.J.; Wijers, R.A.M.J.; de Pasquale, M.; Page, M.

    2011-01-01

    The complex structure of the light curves of Swift GRBs (e.g. superimposed flares and shallow decay) has made their interpretation and that of the blast wave caused by the burst, more difficult than in the pre-Swift era. We aim to constrain the blast wave parameters: electron energy distribution, p,

  5. Genetic diversity of the blast fungus, Magnaporthe grisea (Hebert ...

    African Journals Online (AJOL)

    The effectiveness of some resistance genes indicated that they could be pyramided to provide durable resistance to blast fungus in Burkina Faso. The study also revealed the possible existence of new pathotypes in Burkina Faso. Fifty-five isolates of the blast fungus, Magnaporthe grisea, collected from the nurseries and rice ...

  6. Dry ice blasting for the conservation cleaning of metals

    NARCIS (Netherlands)

    van der Molen, R.; Joosten, I.; Beentjes, T.; Megens, L.; Mardikian, P.; Chemello, C.; Watters, C.; Hull, P.

    2011-01-01

    This research was carried out to assess the feasibility of dry ice blasting as a replacement for solvent cleaning for the removal of organic layers from metal cultural heritage objects. The effects of dry ice blasting on test samples of aluminium, bronze and weathering steel were studied along with

  7. 30 CFR 75.1310 - Explosives and blasting equipment.

    Science.gov (United States)

    2010-07-01

    ... for use so long as the present approval is maintained. (e) Electric detonators shall be compatible... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Explosives and blasting equipment. 75.1310... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1310...

  8. 30 CFR 75.1316 - Preparation before blasting.

    Science.gov (United States)

    2010-07-01

    ... before blasting. (a)(1) All nonbattery-powered electric equipment, including cables, located within 50... cable or detonator circuitry shall not come in contact with energized electric equipment, including... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Preparation before blasting. 75.1316 Section 75...

  9. Investigation on Blast Resistance of Precast Reinforced Concrete Floor Slab

    Science.gov (United States)

    Bonora, Nicola; Gentile, Domenico; Iannitti, Gianluca; Ruggiero, Andrew; Testa, Gabriel; Bernabei, Manuele; Cassioli, Luigi; Grossi, Silvana

    2017-06-01

    The knowledge of the effective blast resistance of civil infrastructures is a fundamental information for risk assessment and modelling consequences of terrorist attack in high population density urban environment. In this work, blast resistance of precast reinforced concrete floor slab, commonly used for commercial parking, was investigated performing blast tests, detonating bare explosive charge of RDX 80-20 in contact with the slab. The charge mass, and the stand-off distance, was varied in order to generate different damage extents, from visible to fully breached condition. Numerical simulations were performed considering all slab structural elements. Failure model for concrete was calibrated on breach size and shape observed in the experiments. The explosive and blast wave-structure interaction were simulated using arbitrary Lagrangian-Eulerian method (ALE) and particle blast method (PBM) for comparison.

  10. SURFACE PREPARATION OF STEEL SUBSTRATES USING GRIT-BLASTING

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen; D. J. Varacalle, Jr.; D. Deason; W. Rhodaberger; E. Sampson

    2005-05-01

    The primary purpose of grit blasting for thermal spray applications is to ensure a strong mechanical bond between the substrate and the coating by the enhanced roughening of the substrate material. This study presents statistically designed experiments that were accomplished to investigate the effect of abrasives on roughness for A36/1020 steel. The experiments were conducted using a Box statistical design of experiment (SDE) approach. Three grit blasting parameters and their effect on the resultant substrate roughness were investigated. These include blast media, blast pressure, and working distance. The substrates were characterized for roughness using surface profilometry. These attributes were correlated with the changes in operating parameters. Twin-Wire Electric Arc (TWEA) coatings of aluminum and zinc/aluminum were deposited on the grit-blasted substrates. These coatings were then tested for bond strength. Bond strength studies were conducted utilizing a portable adhesion tester following ASTM standard D4541.

  11. 30 CFR 56.6404 - Separation of blasting circuits from power source.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Separation of blasting circuits from power... MINES Explosives Electric Blasting § 56.6404 Separation of blasting circuits from power source. (a) Switches used to connect the power source to a blasting circuit shall be locked in the open position except...

  12. 30 CFR 57.6404 - Separation of blasting circuits from power source.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Separation of blasting circuits from power... NONMETAL MINES Explosives Electric Blasting-Surface and Underground § 57.6404 Separation of blasting circuits from power source. (a) Switches used to connect the power source to a blasting circuit shall be...

  13. Proceedings of the seventeenth annual conference on explosives and blasting technique. Volume 2

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Papers from this conference dealt with the following topics: surface and underground mine blasting, ground vibrations and blast effects, design for explosive fracturing of rock, sequential timing for blasting control, design for production optimization, use of blasting for abandoned mine reclamation, chemical explosives, lightning warning systems, magazine security, fire safety, and drilling equipment. Papers have been indexed separately for inclusion on the data base

  14. Survey of rice blast race identity for blast resistance gene identification in the USA and Puerto Rico

    Science.gov (United States)

    Rice blast disease is a significant threat to stable rice production in the USA and worldwide. The major resistance gene (Pi-ta) located within a cluster of resistance genes on rice chromosome 12 has been demonstrated to confer resistance to the rice blast disease. Katy, a rice cultivar released in ...

  15. Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics

    Directory of Open Access Journals (Sweden)

    Papanastasiou Antigoni M

    2007-05-01

    Full Text Available Abstract Background The ability to regulate transgene expression has many applications, mostly concerning the analysis of gene function. Desirable induction characteristics, such as low un-induced expression, high induced expression and limited cellular heterogeneity, can be seriously impaired by chromosomal position effects at the site of transgene integration. Many clones may therefore need to be screened before one with optimal induction characteristics is identified. Furthermore, such screens must be repeated for each new transgene investigated, and comparisons between clones with different transgenes is complicated by their different integration sites. Results To circumvent these problems we have developed a "screen and insert" strategy in which clones carrying a transgene for a fluorescent reporter are first screened for those with optimal induction characteristics. Site-specific recombination (SSR is then be used repeatedly to insert any new transgene at the reporter transgene locus of such clones so that optimal induction characteristics are conferred upon it. Here we have tested in a human fibrosarcoma cell line (HT1080 two of many possible implementations of this approach. Clones (e.g. Rht14-10 in which a GFP reporter gene is very stringently regulated by the tetracycline (tet transactivator (tTA protein were first identified flow-cytometrically. Transgenes encoding luciferase, I-SceI endonuclease or Rad52 were then inserted by SSR at a LoxP site adjacent to the GFP gene resulting stringent tet-regulated transgene expression. In clone Rht14-10, increases in expression from essentially background levels (+tet to more than 104-fold above background (-tet were reproducibly detected after Cre-mediated insertion of either the luciferase or the I-SceI transgenes. Conclusion Although previous methods have made use of SSR to integrate transgenes at defined sites, none has effectively combined this with a pre-selection step to identify

  16. BLAST: RESOLVING THE COSMIC SUBMILLIMETER BACKGROUND

    International Nuclear Information System (INIS)

    Marsden, Gaelen; Chapin, Edward L.; Halpern, Mark; Ngo, Henry; Ade, Peter A. R.; Griffin, Matthew; Hargrave, Peter C.; Mauskopf, Philip; Moncelsi, Lorenzo; Pascale, Enzo; Bock, James J.; Devlin, Mark J.; Dicker, Simon R.; Klein, Jeff; Gundersen, Joshua O.; Hughes, David H.; Magnelli, Benjamin; Netterfield, Calvin B.; Olmi, Luca; Patanchon, Guillaume

    2009-01-01

    The Balloon-borne Large Aperture Submillimeter Telescope (BLAST) has made 1 deg 2 , deep, confusion-limited maps at three different bands, centered on the Great Observatories Origins Deep Survey South Field. By calculating the covariance of these maps with catalogs of 24 μm sources from the Far-Infrared Deep Extragalactic Legacy Survey, we have determined that the total submillimeter intensities are 8.60 ± 0.59, 4.93 ± 0.34, and 2.27 ± 0.20 nW m -2 sr -1 at 250, 350, and 500 μm, respectively. These numbers are more precise than previous estimates of the cosmic infrared background (CIB) and are consistent with 24 μm-selected galaxies generating the full intensity of the CIB. We find that the fraction of the CIB that originates from sources at z ≥ 1.2 increases with wavelength, with 60% from high-redshift sources at 500 μm. At all BLAST wavelengths, the relative intensity of high-z sources is higher for 24 μm-faint sources than that for 24 μm-bright sources. Galaxies identified as active galactic nuclei (AGNs) by their Infrared Array Camera colors are 1.6-2.6 times brighter than the average population at 250-500 μm, consistent with what is found for X-ray-selected AGNs. BzK-selected galaxies are found to be moderately brighter than typical 24 μm-selected galaxies in the BLAST bands. These data provide high-precision constraints for models of the evolution of the number density and intensity of star-forming galaxies at high redshift.

  17. Carbon Tubular Morphologies in Blast Furnace Coke

    Directory of Open Access Journals (Sweden)

    Stanislav S. Gornostayev

    2008-01-01

    Full Text Available The paper reports on the first occurrence of microscale carbon tubular morphologies (CMTs in a blast furnace (BF coke. The CMTs were probably formed as a result of the conversion of solid disordered carbon via liquid phase metal particles involving a gas phase containing a substantial amount of N2 and O2. The presence of CMTs may lie behind the generation of the smallest fraction of fines in BF exhaust dust. If the amount of CMTs present in the BF exhausts gases at any particular metallurgical site proves to be substantial, it could become a subject of environmental concern.

  18. Rock breaking methods to replace blasting

    Science.gov (United States)

    Zhou, Huisheng; Xie, Xinghua; Feng, Yuqing

    2018-03-01

    The method of breaking rock by blasting has a high efficiency and the cost is relatively low, but the associated vibration, flyrock, production of toxic gases since the 1970’s, the Western developed countries began to study the safety of breaking rock. This paper introduces different methods and their progress to safely break rock. Ideally, safe rock breaking would have little vibration, no fly stone, and no toxic gases, which can be widely used in municipal engineering, road excavation, high-risk mining, quarrying and complex environment.

  19. Design of blast simulators for nuclear testing

    International Nuclear Information System (INIS)

    Mark, A.; Opalka, K.O.; Kitchens, C.W. Jr.

    1983-01-01

    A quasi-one-dimensional computational technique is used to model the flow of a large, complicated shock tube. The shock tube, or Large Blast Simulator, is used to simulate conventional or nuclear explosions by shaping the pressure history. Results from computations show favorable agreement when compared with data taken in the facility at Gramat, France. Such future shock tubes will include a thermal irradiation capability to better simulate a nuclear event. The computations point to the need for venting of the combustion products since the pressure history will be considerably altered as the shock propagates through these hot gases

  20. Explosive and accessories in rock blasting

    Energy Technology Data Exchange (ETDEWEB)

    Pingua, B.M.P.; Nabiullah, M.; Jagdish, S.; Mishra, G.D.; Singh, T.N. [Central Mining Research Institute, Dhanbad (India)

    1999-02-01

    Chemical explosives are commonly used in the mining industry. Those used in India include nitroglycerine (NG) base, ammonium nitrate fuel oil mixture (ANFO), slurry emulsion and liquid oxygen (LOX). Examples of each type and their general properties are lighted. The electric and non-electric detonating systems used are described. Two Indian companies are producing non-electric in-hole delay system. Raydet (IDL-make) and Excel (ICI-make). Their firing characteristics are listed. Tables are given for burden for different density of rock and explosive strength. Causes of bad blast are itemised. 7 refs., 4 figs., 7 tabs.

  1. Historic and future trends of vehicle emissions in Beijing, 1998-2020: A policy assessment for the most stringent vehicle emission control program in China

    Science.gov (United States)

    Zhang, Shaojun; Wu, Ye; Wu, Xiaomeng; Li, Mengliang; Ge, Yunshan; Liang, Bin; Xu, Yueyun; Zhou, Yu; Liu, Huan; Fu, Lixin; Hao, Jiming

    2014-06-01

    As a pioneer in controlling vehicle emissions within China, Beijing released the Clean Air Action Plan 2013-2017 document in August 2013 to improve its urban air quality. It has put forward this plan containing the most stringent emission control policies and strategies to be adopted for on-road vehicles of Beijing. This paper estimates the historic and future trends and uncertainties in vehicle emissions of Beijing from 1998 to 2020 by applying a new emission factor model for the Beijing vehicle fleet (EMBEV). Our updated results show that total emissions of CO, THC, NOx and PM2.5 from the Beijing vehicle fleet are 507 (395-819) kt, 59.1 (41.2-90.5) kt, 74.7 (54.9-103.9) kt and 2.69 (1.91-4.17) kt, respectively, at a 95% confidence level. This represents significant reductions of 58%, 59%, 31% and 62%, respectively, relative to the total vehicle emissions in 1998. The past trends clearly posed a challenge to NOx emission mitigation for the Beijing vehicle fleet, especially in light of those increasing NOx emissions from heavy-duty diesel vehicles (HDDVs) which have partly offset the reduction benefit from light-duty gasoline vehicles (LDGVs). Because of recently announced vehicle emission controls to be adopted in Beijing, including tighter emissions standards, limitations on vehicle growth by more stringent license control, promotion of alternative fuel technologies (e.g., natural gas) and the scrappage of older vehicles, estimated vehicle emissions in Beijing will continue to be mitigated by 74% of CO, 68% of THC, 56% of NOx and 72% of PM2.5 in 2020 compared to 2010 levels. Considering that many of the megacities in China are facing tremendous pressures to mitigate emissions from on-road vehicles, our assessment will provide a timely case study of significance for policy-makers in China.

  2. Stand-Off Device for Plastic Debris Recognition in Post-Blast Scenarios

    Directory of Open Access Journals (Sweden)

    Valeria Spizzichino

    2016-12-01

    Full Text Available The fast analysis of crime scenes is a very critical issue for investigators that should collect, as much as possible, all and only meaningful evidence, and rapidly bring back to normality the involved area. With the scope to respond to the end user’s requirements, the project FORLAB (Forensic Laboratory for in-situ evidence analysis in a post blast scenario has set, as its main goal, to develop a system of sensors for fast screening of post-blast scenes. In this frame, a new sensor based on laser induced fluorescence has been developed for standoff individuation and localization of plastic debris in post-blast scenarios. The system can scan large areas in short times (in some cases, minutes providing real-time images of the scene where material discrimination is highlighted. In fact, the combined use of a laser source with a high repetition rate and of a signal collection setup based on a fixed intensified charged coupled device (ICCD with a large field of view has allowed for the brief duration of the scanning process. In addition, dedicated software elaborates the fluorescence data obtained from the targets and retrieves a chemical characterization useful for material recognition.

  3. Discriminant Model of Coal Mining Microseismic and Blasting Signals Based on Waveform Characteristics

    Directory of Open Access Journals (Sweden)

    Baolin Li

    2017-01-01

    Full Text Available Generally, there are two important types of microseismic (MS signals caused by mining and blasting activities at coal mines. The waveform characteristics of MS signals using FFT, STA/LTA method, and envelope analysis were studied to distinguish these two types of MS signals. The main results are as follows: the dominant frequency and duration of two types of signals are significantly different. The following peak envelope curves of two types of MS signals fit a power function. The power exponent was obtained to describe the attenuated speed of the MS signals. The attenuation of the coal mining MS signals is slower and more fluctuant than that of the blasting signal. Waveform characteristics consisting of the dominant frequency, duration, and attenuation coefficient were extracted as the discriminating parameters. The discriminating performance of these parameters was compared and discussed. Based on the waveform characteristics, a discriminant model for coal mining MS and blasting signals was established by using Fisher linear discriminant method and its performance was checked. The results show that the accuracy of the discriminant model is more than 85%, which can meet the requirements of MS monitoring at coal mines.

  4. Fabrication of Biochips with Micro Fluidic Channels by Micro End-milling and Powder Blasting

    Directory of Open Access Journals (Sweden)

    Dong Sam Park

    2008-02-01

    Full Text Available For microfabrications of biochips with micro fluidic channels, a large number of microfabrication techniques based on silicon or glass-based Micro-Electro-Mechanical System (MEMS technologies were proposed in the last decade. In recent years, for low cost and mass production, polymer-based microfabrication techniques by microinjection molding and micro hot embossing have been proposed. These techniques, which require a proper photoresist, mask, UV light exposure, developing, and electroplating as a preprocess, are considered to have some problems. In this study, we propose a new microfabrication technology which consists of micro end-milling and powder blasting. This technique could be directly applied to fabricate the metal mold without any preprocesses. The metal mold with micro-channels is machined by micro end-milling, and then, burrs generated in the end-milling process are removed by powder blasting. From the experimental results, micro end-milling combined with powder blasting could be applied effectively for fabrication of the injection mold of biochips with micro fluidic channels.

  5. Optimization of a Steel Plant with Multiple Blast Furnaces Under Biomass Injection

    Science.gov (United States)

    Wiklund, Carl-Mikael; Pettersson, Frank; Saxén, Henrik

    2013-04-01

    The allocation of resources between several blast furnaces in an integrated steelmaking plant is studied with the aim of finding the lowest specific operation cost for steel production. In order to reduce the use of fossil fuels, biomass was considered as an auxiliary reductant in the furnace after partial pyrolysis in an external unit, as a complement to heavy fuel oil. The optimization considers raw material, energy, and emission costs and a possible credit for sold power and heat. To decrease computational requirements and to guarantee that the global optimum is found, a piecewise linearized model of the blast furnace was used in combination with linear models of the sinter-, coke-, and power plants, hot stoves, and basic oxygen furnace. The optimization was carried out under different constraints on the availability of some raw materials as well as for different efficiencies of the hot stoves of the blast furnaces. The results indicate that a non-uniform distribution of the production between the furnaces can be advantageous, and some surprising findings concerning the optimal resource allocation under constrained operation are reported.

  6. Distinguishing the Unique Neuropathological Profile of Blast Polytrauma

    Directory of Open Access Journals (Sweden)

    W. Brad Hubbard

    2017-01-01

    Full Text Available Traumatic brain injury sustained after blast exposure (blast-induced TBI has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden. In addition, unprotected civilians sustain primary blast lung injury (PBLI at alarming rates. Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT with symptoms from blast-induced mild TBI (mTBI. Currently, there is a lack of preclinical models simulating BPT, which is crucial to identifying unique injury mechanisms of BPT and its management. To meet this need, our group characterized a rodent model of BPT and compared results to a blast-induced mTBI model. Open field (OF performance trials were performed on rodents at 7 days after injury. Immunohistochemistry was performed to evaluate cellular outcome at day seven following BPT. Levels of reactive astrocytes (GFAP, apoptosis (cleaved caspase-3 expression, and vascular damage (SMI-71 were significantly elevated in BPT compared to blast-induced mTBI. Downstream markers of hypoxia (HIF-1α and VEGF were higher only after BPT. This study highlights the need for unique therapeutics and prehospital management when handling BPT.

  7. LTC vacuum blasting maching (concrete): Baseline report: Greenbook (Chapter)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-31

    The LTC shot blast technology was tested and is being evaluated at Florida International University (FIU) as a baseline technology. In conjuction with FIU`s evaluation of efficiency and cost, this report covers the evaluation conducted for safety and health issues. It is a commercially available technology and has been used for various projects at locations throughout the country. The LTC 1073 Vacuum Blasting Machine uses a high-capacity, direct-pressure blasting system which incorporates a continuous feed for the blast media. The blast media cleans the surface within the contained brush area of the blast. It incorporates a vacuum system which removes dust and debris from the surface as it is blasted. The safety and health evaluation during the testing demonstration focused on two main areas of exposure: dust and noise. Dust exposure during maintenance activities was minimal, but due to mechanical difficulties dust monitoring could not be conducted during operation. Noise exposure was significant. Further testing for each of these exposures is recommended because of the outdoor environment where the testing demonstration took place. This may cause the results to be inaccurate. It is feasible that the dust and noise levels will be higher in an enclosed environment. In addition, other safety and health issues found were ergonomics, heat stress, tripping hazards, electrical hazards, lockout/tagout, and arm-hand vibration.

  8. Discrimination of Earthquake and Blast Seismicity in Western Alberta

    Science.gov (United States)

    Spriggs, N.; Law, A.; Yenier, E.; Reynen, A.; Baturan, D.

    2015-12-01

    Recorded seismicity in western Alberta is caused by natural and induced earthquakes or blast events from mining and quarry operations. Accurate discrimination of earthquakes from blast events is crucial for evaluating recent seismicity with respect to the historical catalog and for assessing seismic hazards associated with naturally occurring or induced seismicity. In general, blast events are discriminated from earthquakes based on their proximity to active mines and quarries in addition to day-of-week and time-of-day timing patterns. In some parts of western Alberta, however, seismicity originates in regions with active mines, historical earthquake seismicity, and hydraulic fracturing operations. Based on timing patterns or event locations alone, natural or induced seismicity may be misidentified as mining activity. Several studies report that relative differences in Fourier or response spectra can be used to discriminate blast and earthquake events. Other studies report that the relative timing and amplitude of seismic phases may provide useful metrics for classifying blast events. Here we propose an alternative method that accounts for both differences in phase spectra and phase timing and amplitude. In particular, we evaluate the normalized time integral for characteristic functions of particle motion from confirmed blast and earthquake events recorded by regional Alberta seismic networks. We then use these time-integral profiles to re-classify events that are initially categorized as suspected blasts based on timing pattern and event location indicators.

  9. A multiphysics-viscoplastic cap model for simulating blast response of cemented tailings backfill

    Directory of Open Access Journals (Sweden)

    Gongda Lu

    2017-06-01

    Full Text Available Although a large number of previous researches have significantly contributed to the understanding of the quasi-static mechanical behavior of cemented tailings backfill, an evolutive porous medium used in underground mine cavities, very few efforts have been made to improve the knowledge on its response under sudden dynamic loading during the curing process. In fact, there is a great need for such information given that cemented backfill structures are often subjected to blast loadings due to mine exploitations. In this study, a coupled thermo-hydro-mechanical-chemical (THMC-viscoplastic cap model is developed to describe the behavior of cementing mine backfill material under blast loading. A THMC model for cemented backfill is adopted to evaluate its behavior and evolution of its properties in curing processes with coupled thermal, hydraulic, mechanical and chemical factors. Then, the model is coupled to a Perzyna type of viscoplastic model with a modified smooth surface cap envelope and a variable bulk modulus, in order to reasonably capture the nonlinear and rate-dependent behaviors of the cemented tailings backfill under blast loading. All of the parameters required for the variable-modulus viscoplastic cap model were obtained by applying the THMC model to reproducing evolution of cemented paste backfill (CPB properties in the curing process. Thus, the behavior of hydrating cemented backfill under high-rate impacts can be evaluated under any curing time of concern. The validation results of the proposed model indicate a good agreement between the experimental and the simulated results. The authors believe that the proposed model will contribute to a better understanding of the performance of hydrating cemented backfill under blasting, and also to practical risk management of backfill structures associated with such a dynamic condition.

  10. Modeling of aqueous foam blast wave attenuation

    Directory of Open Access Journals (Sweden)

    Domergue L.

    2011-01-01

    Full Text Available The use of aqueous foams enables the mitigation of blast waves induced by the explosion of energetic materials. The two-phase confinement gives rise to interphase interactions between the gaseous and liquid phases, which role have been emphasized in shock-tube studies with solid foams [1, 2]. Multifluid formalism enables the thermo-mechanical disequilibria between phases to be taken into account. The flow model ensures the correct estimation of the acoustic impedance of the two-phase media. As for the numerical scheme, Riemann solvers are used to describe the microscopic fluid interactions, the summation of which provides the multiphase flux. The role of the different transfer mechanisms is evaluated in the case where the liquid ligaments of the foam matrix have been shattered into droplets by the shock impingement. Characteristics of blast waves in heterogeneous media leads to a decrease of overpressure. The numerical results have been compared favorably to experimental data [3, 4].

  11. Compressive strength after blast of sandwich composite materials.

    Science.gov (United States)

    Arora, H; Kelly, M; Worley, A; Del Linz, P; Fergusson, A; Hooper, P A; Dear, J P

    2014-05-13

    Composite sandwich materials have yet to be widely adopted in the construction of naval vessels despite their excellent strength-to-weight ratio and low radar return. One barrier to their wider use is our limited understanding of their performance when subjected to air blast. This paper focuses on this problem and specifically the strength remaining after damage caused during an explosion. Carbon-fibre-reinforced polymer (CFRP) composite skins on a styrene-acrylonitrile (SAN) polymer closed-cell foam core are the primary composite system evaluated. Glass-fibre-reinforced polymer (GFRP) composite skins were also included for comparison in a comparable sandwich configuration. Full-scale blast experiments were conducted, where 1.6×1.3 m sized panels were subjected to blast of a Hopkinson-Cranz scaled distance of 3.02 m kg(-1/3), 100 kg TNT equivalent at a stand-off distance of 14 m. This explosive blast represents a surface blast threat, where the shockwave propagates in air towards the naval vessel. Hopkinson was the first to investigate the characteristics of this explosive air-blast pulse (Hopkinson 1948 Proc. R. Soc. Lond. A 89, 411-413 (doi:10.1098/rspa.1914.0008)). Further analysis is provided on the performance of the CFRP sandwich panel relative to the GFRP sandwich panel when subjected to blast loading through use of high-speed speckle strain mapping. After the blast events, the residual compressive load-bearing capacity is investigated experimentally, using appropriate loading conditions that an in-service vessel may have to sustain. Residual strength testing is well established for post-impact ballistic assessment, but there has been less research performed on the residual strength of sandwich composites after blast.

  12. Protecting the lower extremity against a/p blast mines

    CSIR Research Space (South Africa)

    van Dyk, T

    2006-09-01

    Full Text Available protection concept Result: Chaos and arguments Slide 4 © CSIR 2006 www.csir.co.za A/P Blast Mines Effects Slide 5 © CSIR 2006 www.csir.co.za Basic Principles Shock Effect Slide 6 © CSIR 2006... the Lower Extremity against a/p Blast Mines J T van Dyk DEFENCE, PEACE, SAFETY AND SECURITY LANDWARDS SCIENCES COMPETENCY AREA Slide 2 © CSIR 2006 www.csir.co.za Contents • R&D overview • Effect of a/p blast mines • Basic...

  13. The tank's dynamic response under nuclear explosion blast wave

    International Nuclear Information System (INIS)

    Xu Mei; Wang Lianghou; Li Xiaotian; Yu Suyuan; Zhang Zhengming; Wan Li

    2005-01-01

    To weapons and equipment, blast wave is the primary destructive factor. In this paper, taken the real model-59 tank as an example, we try to transform the damage estimation problem into computing a fluid structure interaction problem with finite element method. The response of tank under nuclear explosion blast wave is computed with the general-coupling algorithm. Also, the dynamical interaction of blast wave and tank is reflected in real time. The deformation of each part of the tank is worked out and the result corresponds to the real-measured data. (authors)

  14. Lateral blasts at Mount St. Helens and hazard zonation

    Science.gov (United States)

    Crandell, D.R.; Hoblitt, R.P.

    1986-01-01

    Lateral blasts at andesitic and dacitic volcanoes can produce a variety of direct hazards, including ballistic projectiles which can be thrown to distances of at least 10 km and pyroclastic density flows which can travel at high speed to distances of more than 30 km. Indirect effect that may accompany such explosions include wind-borne ash, pyroclastic flows formed by the remobilization of rock debris thrown onto sloping ground, and lahars. Two lateral blasts occurred at a lava dome on the north flank of Mount St. Helens about 1200 years ago; the more energetic of these threw rock debris northeastward across a sector of about 30?? to a distance of at least 10 km. The ballistic debris fell onto an area estimated to be 50 km2, and wind-transported ash and lapilli derived from the lateral-blast cloud fell on an additional lobate area of at least 200 km2. In contrast, the vastly larger lateral blast of May 18, 1980, created a devastating pyroclastic density flow that covered a sector of as much as 180??, reached a maximum distance of 28 km, and within a few minutes directly affected an area of about 550 km2. The May 18 lateral blast resulted from the sudden, landslide-induced depressurization of a dacite cryptodome and the hydrothermal system that surrounded it within the volcano. We propose that lateral-blast hazard assessments for lava domes include an adjoining hazard zone with a radius of at least 10 km. Although a lateral blast can occur on any side of a dome, the sector directly affected by any one blast probably will be less than 180??. Nevertheless, a circular hazard zone centered on the dome is suggested because of the difficulty of predicting the direction of a lateral blast. For the purpose of long-term land-use planning, a hazard assessment for lateral blasts caused by explosions of magma bodies or pressurized hydrothermal systems within a symmetrical volcano could designate a circular potential hazard area with a radius of 35 km centered on the volcano

  15. Relativistic blast waves in two dimensions. I - The adiabatic case

    Science.gov (United States)

    Shapiro, P. R.

    1979-01-01

    Approximate solutions are presented for the dynamical evolution of strong adiabatic relativistic blast waves which result from a point explosion in an ambient gas in which the density varies both with distance from the explosion center and with polar angle in axisymmetry. Solutions are analytical or quasi-analytical for the extreme relativistic case and numerical for the arbitrarily relativistic case. Some general properties of nonplanar relativistic shocks are also discussed, including the incoherence of spherical ultrarelativistic blast-wave fronts on angular scales greater than the reciprocal of the shock Lorentz factor, as well as the conditions for producing blast-wave acceleration.

  16. Analysis of the Rheological Behaviour of Selected Semi-Solid Slag Systems in Blast Furnace Flow Conditions

    Directory of Open Access Journals (Sweden)

    Migas P.

    2015-04-01

    Full Text Available The rheological properties of liquid and semi-solid systems of slag and hot metal in a blast furnace are extremely important from the perspective of their dripping in the unit. The rheological nature and the values of the dynamic viscosity coefficient of liquid and semi-solid phases - slag and hot metal - determine the permeability of the zones in which those systems exist. The modelling of dripping processes and e.g. static and dynamic holding/retention of liquid in the bed, requires an accurate description of the rheological behaviour of slag and iron systems. Determining the liquid flow through the lump bed of the blast furnace is based on the assumption that liquids in the unit in the whole range of their occurrence are similar to a Newtonian ideal liquid. This study presents an analysis of the findings of high-temperature rheometric measurements of CaO-SiO2-Al2O3-MgO systems, liquid, semi-solid slags of the blast furnace type doped with TiO2 and solids in the form of TiN. The tests were performed within a temperature range of 1310-1490°C. Also measurement results for glycerol solutions with concentrations of 86% and 100% at the ambient temperature, simulating blast furnace slags with various contents of solids - PC, anthracite - are presented.

  17. E-cigarette Blast Injury: Complex Facial Fractures and Pneumocephalus

    Directory of Open Access Journals (Sweden)

    Benjamin Archambeau

    2016-11-01

    Full Text Available Electronic cigarettes (also known as e-cigarettes or e-cigs are becoming a popular method of recreational nicotine use over recent years. The growth of new brands and devices has been outpacing the FDA’s ability to regulate them. As a result, some of these devices fail without warning, most likely from malfunction of the lithium-ion batteries that are in close proximity to volatile compounds within the device. Failures have occurred during both use and storage of the devices or their components. The subsequent injuries from several of these events, including full thickness burns requiring grafting and blast injuries, have been observed at Arrowhead Regional Medical Center, a regional trauma and burn center in southern California. One severe case resulted in several maxillofacial fractures, blurred vision, and pneumocephalus after a device failed catastrophically during use. The patient required close monitoring with serial imaging by neurosurgery in the intensive care unit and multiple procedures by oral maxillofacial surgery to reconstruct his facial bones and soft tissue. Ultimately, the patient recovered with minimal permanent damage, but the potential for further injury or even death was apparent. Cases such as this one are becoming more frequent. It is important to increase awareness of this growing problem for both medical professionals and the general public in order to curb this concerning new trend.

  18. Biomarkers of Blast-Induced Neurotrauma: Profiling Molecular and Cellular Mechanisms of Blast Brain Injury

    Science.gov (United States)

    2009-06-01

    common locations are the corticome- dullary (gray matter-white matter) junction (particularly in the frontal and temporal areas), the internal capsule ...Vascular responses and dysregulation of cell adhesion molecules as bridges connecting vascular-endothelial- neural tissue disturbances, including but not...3371–3376. Lew, H.L. (2005). Rehabilitation needs of an increasing popula- tion of patients: Traumatic brain injury, polytrauma, and blast-related

  19. Blasting injuries in surface mining with emphasis on flyrock and blast area security

    Energy Technology Data Exchange (ETDEWEB)

    Bajpayee, T.S.; Rehak, T.R.; Mowrey, G.L.; Ingram, D.K. [NIOSH, Pittsburgh, PA (USA). Pittsburgh Research Lab.

    2004-07-01

    Blasting is a hazardous component of surface mining. Serious injuries and fatalities result from improper judgment or practice during rock blasting. This paper describes several fatal injury case studies, analyzes causative factors, and emphasizes preventive measures. During the 21-year period from 1978 to 1998, the mean yearly explosive-related injuries (fatal and nonfatal) for surface coal mines was 8.86 (95% CI: 6.38-11.33), and for surface metal/nonmetal mines 10.76 (95% CI: 8.39-13.14). Flyrock and lack of blast area security accounted for 68.2% of these injuries. Case studies indicate that the causative factors for fatal injuries are primarily personal and task-related and to some extent environmental. A reduction in the annual injuries in surface coal mines was observed during the 10-year period of 1989-1998 (5.80 (95% CI: 2.71-8.89)) compared to the previous 10-year period of 1979-1988 (10.90 (95% CI: 7.77-14.14)). However, such reduction was not noticed in the metal/nometal sector (i.e., 9.30 (95% CI: 6.84-11.76) for the period 1989-1998 compared with 11.00 (95% CI: 7.11-14.89) for the period 1979-1988). Discussion of case studies during safety meetings will help to mitigate fatal injuries and derive important payoffs in terms of lower risks and costs of injuries.

  20. An Operational Model for the Prediction of Jet Blast

    Science.gov (United States)

    2012-01-09

    This paper presents an operational model for the prediction of jet blast. The model was : developed based upon three modules including a jet exhaust model, jet centerline decay : model and aircraft motion model. The final analysis was compared with d...

  1. Damage to underground coal mines caused by surface blasting

    International Nuclear Information System (INIS)

    Fourie, A.B.; Green, R.W.

    1993-01-01

    An investigation of the potential damage to underground coal workings as a result of surface blasting at an opencast coal mine is described. Seismometers were installed in a worked out area of an underground mine, in the eastern Transvaal region of South Africa, and the vibration caused by nearby surface blasting recorded. These measurements were used to derive peak particle velocities. These velocities were correlated with observed damage underground in order to establish the allowable combination of the two blasting parameters of charge mass per relay, and blast-to-gage point distance. An upper limit of 110mm/sec peak particle velocity was found to be sufficient to ensure that the damage to the particular workings under consideration was minimal. It was further found that a cube-root scaling law provided a better fit to the field data than the common square-root law. 11 refs., 6 figs., 5 tabs

  2. BICARBONATE OF SODA BLASTING TECHNOLOGY FOR AIRCRAFT WHEEL PAINTING

    Science.gov (United States)

    This evaluation addressed product quality, waste reduction/pollution prevention and economics in replacing chemical solvent strippers with a bicarbonate of soda blasting technology for removal of paint from aircraft wheels. The evaluation was conducted in the Paint Stripping Sho...

  3. Blast Load Response of Steel Sandwich Panels with Liquid Encasement

    Energy Technology Data Exchange (ETDEWEB)

    Dale Karr; Marc Perlin; Benjamin Langhorst; Henry Chu

    2009-10-01

    We describe an experimental investigation of the response of hybrid blast panels for protection from explosive and impact forces. The fundamental notion is to dissipate, absorb, and redirect energy through plastic collapse, viscous dissipation, and inter-particle forces of liquid placed in sub-structural compartments. The panels are designed to absorb energy from an impact or air blast by elastic-plastic collapse of the panel substructure that includes fluid-filled cavities. The fluid contributes to blast effects mitigation by providing increased initial mass and resistance, by dissipation of energy through viscosity and fluid flow, and by redirecting the momentum that is imparted to the system from the impact and blast impulse pressures. Failure and deformation mechanisms of the panels are described.

  4. Spreading of sediment due to underwater blasting and dredging

    DEFF Research Database (Denmark)

    Nielsen, Morten Holtegaard; Bach, Lis; Bollwerk, Sandra

    2015-01-01

    leads to a wider spreading of the organic part of the sediment. Almost all material less than 2 μm, including surficial clay minerals and much organic material, was transported away from the construction site and its vicinity, which could imply mobilization and export of pollutants. Environmental...... impacts of suspended sediment from underwater blasting, which could include coverage of the benthos or increased turbidity, can be managed by timing the blast favourably relative to currents, waves and stratification. It is argued that the environmental impact of blasting can be minimized by decreasing...... out in connection with the construction of a new quay at the existing harbour of Sisimiut, Greenland. Subsequent to the largest of a series of underwater blasts, the distribution of suspended sediment in the water column at and around the construction site was observed using a CTD (Conductivity...

  5. Seismic stations with GSM telemetry for registration of quarry blasts

    Czech Academy of Sciences Publication Activity Database

    Brož, Milan; Číž, Radim; Málek, Jiří; Žanda, Libor

    2000-01-01

    Roč. 2000, 16 (118) (2000), s. 25-32 ISSN 1211-1910 Institutional research plan: CEZ:AV0Z3046908 Keywords : blasting * seismic station * GSM mobile modem Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  6. Seismic safety in conducting large-scale blasts

    Science.gov (United States)

    Mashukov, I. V.; Chaplygin, V. V.; Domanov, V. P.; Semin, A. A.; Klimkin, M. A.

    2017-09-01

    In mining enterprises to prepare hard rocks for excavation a drilling and blasting method is used. With the approach of mining operations to settlements the negative effect of large-scale blasts increases. To assess the level of seismic impact of large-scale blasts the scientific staff of Siberian State Industrial University carried out expertise for coal mines and iron ore enterprises. Determination of the magnitude of surface seismic vibrations caused by mass explosions was performed using seismic receivers, an analog-digital converter with recording on a laptop. The registration results of surface seismic vibrations during production of more than 280 large-scale blasts at 17 mining enterprises in 22 settlements are presented. The maximum velocity values of the Earth’s surface vibrations are determined. The safety evaluation of seismic effect was carried out according to the permissible value of vibration velocity. For cases with exceedance of permissible values recommendations were developed to reduce the level of seismic impact.

  7. Study of wet blasting of components in nuclear power stations

    International Nuclear Information System (INIS)

    Hall, J.

    1999-12-01

    This report looks at the method of wet blasting radioactive components in nuclear power stations. The wet blaster uses pearl shaped glass beads with the dimensions of 150-250 μm mixed with water as blasting media. The improved design, providing outer operator's positions with proper radiation protection and more efficient blasting equipment has resulted in a lesser dose taken by the operators. The main reason to decontaminate components in nuclear power plants is to enable service on these components. On components like valves, pump shafts, pipes etc. oxides form and bind radiation. These components are normally situated at some distance from the reactor core and will mainly suffer from radiation from so called activation products. When a component is to be decontaminated it can be decontaminated to a radioactive level where it will be declassified. This report has found levels ranging from 150-1000 Bq/kg allowing declassification of radioactive materials. This difference is found between different countries and different organisations. The report also looks at the levels of waste generated using wet blasting. This is done by tracking the contamination to determine where it collects. It is either collected in the water treatment plant or collected in the blasting media. At Barsebaeck the waste levels, from de-contaminating nearly 800 components in one year, results in a waste volume of about 0,250 m 3 . This waste consists of low and medium level waste and will cost about 3 600 EURO to store. The conclusions of the report are that wet blasting is an indispensable way to treat contaminated components in modern nuclear power plants. The wet blasting equipment can be improved by using a robot enabling the operators to remotely treat components from the outer operator's positions. There they will benefit from better radiation protection thus further reduce their taken dose. The wet blasting equipment could also be used to better control the levels of radioactivity on

  8. A New Middle Path Approach For Alignements In Blast

    OpenAIRE

    Garg, Deepak; Saxena, S C; Bhardwaj, L M

    2012-01-01

    This paper deals with a new middle path approach developed for reducing alignment calculations in BLAST algorithm. This is a new step which is introduced in BLAST algorithm in between the ungapped and gapped alignments. This step of middle path approach between the ungapped and gapped alignments reduces the number of sequences going for gapped alignment. This results in the improvement in speed for alignment up to 30 percent.

  9. Pellet reduction properties under different blast furnace operating conditions

    OpenAIRE

    Leimalm, Ulrika

    2006-01-01

    One of the aims of modern blast furnace (BF) ironmaking is to reduce coke consumption. One way is to increase the injection of reduction agents, such as pulverized coal. An increase in pulverized coal injection rate (PCR) will affect the blast furnace process and the conditions for iron oxide reduction. Changes in PCR influence the composition of the ascending gases and the in-furnace temperature isotherms. The performed tests involve full-scale, pilot and laboratory investigations. Raw mater...

  10. Remote operated vehicle with carbon dioxide blasting (ROVCO2)

    International Nuclear Information System (INIS)

    Resnick, A.M.

    1995-01-01

    The Remote Operated Vehicle with Carbon Dioxide Blasting (ROVCO 2 ), as shown in a front view, is a six-wheeled remote land vehicle used to decontaminate concrete floors. The remote vehicle has a high pressure Cryogenesis blasting subsystem, Oceaneering Technologies (OTECH) developed a CO 2 xY Orthogonal Translational End Effector (COYOTEE) subsystem, and a vacuum/filtration and containment subsystem. Figure 2 shows a block diagram with the various subsystems labeled

  11. PaperBLAST: Text Mining Papers for Information about Homologs.

    Science.gov (United States)

    Price, Morgan N; Arkin, Adam P

    2017-01-01

    Large-scale genome sequencing has identified millions of protein-coding genes whose function is unknown. Many of these proteins are similar to characterized proteins from other organisms, but much of this information is missing from annotation databases and is hidden in the scientific literature. To make this information accessible, PaperBLAST uses EuropePMC to search the full text of scientific articles for references to genes. PaperBLAST also takes advantage of curated resources (Swiss-Prot, GeneRIF, and EcoCyc) that link protein sequences to scientific articles. PaperBLAST's database includes over 700,000 scientific articles that mention over 400,000 different proteins. Given a protein of interest, PaperBLAST quickly finds similar proteins that are discussed in the literature and presents snippets of text from relevant articles or from the curators. PaperBLAST is available at http://papers.genomics.lbl.gov/. IMPORTANCE With the recent explosion of genome sequencing data, there are now millions of uncharacterized proteins. If a scientist becomes interested in one of these proteins, it can be very difficult to find information as to its likely function. Often a protein whose sequence is similar, and which is likely to have a similar function, has been studied already, but this information is not available in any database. To help find articles about similar proteins, PaperBLAST searches the full text of scientific articles for protein identifiers or gene identifiers, and it links these articles to protein sequences. Then, given a protein of interest, it can quickly find similar proteins in its database by using standard software (BLAST), and it can show snippets of text from relevant papers. We hope that PaperBLAST will make it easier for biologists to predict proteins' functions.

  12. Power Tillers for Demining: Blast Test

    Directory of Open Access Journals (Sweden)

    Emanuela Elisa Cepolina

    2007-06-01

    Full Text Available Power tillers are very simple and versatile machines with large scale diffusion in developing countries, where they are commonly used both for agriculture and for transportation purposes. A new integrated participatory approach that makes use of and improves local end-users knowledge has been used to design a new robotic system for humanitarian demining applications in Sri Lanka, using power tiller as core module. A demining machine composed by a tractor unit, a ground processing tool and a vegetation cutting tool is here presented together with results obtained from the first blast test on the preliminary version of tractor unit armouring. Different breakable connections between wheels and axle have been designed to cause physical detachment and interrupt the transmission of the shock wave released by the explosion of a mine under one wheel. Effects of explosions on different types of wheels and on the chassis have been recorded and commented.

  13. Power Tillers for Demining: Blast Test

    Directory of Open Access Journals (Sweden)

    Emanuela Elisa Cepolina

    2008-11-01

    Full Text Available Power tillers are very simple and versatile machines with large scale diffusion in developing countries, where they are commonly used both for agriculture and for transportation purposes. A new integrated participatory approach that makes use of and improves local end-users knowledge has been used to design a new robotic system for humanitarian demining applications in Sri Lanka, using power tiller as core module. A demining machine composed by a tractor unit, a ground processing tool and a vegetation cutting tool is here presented together with results obtained from the first blast test on the preliminary version of tractor unit armouring. Different breakable connections between wheels and axle have been designed to cause physical detachment and interrupt the transmission of the shock wave released by the explosion of a mine under one wheel. Effects of explosions on different types of wheels and on the chassis have been recorded and commented.

  14. Blast Testing and Modelling of Composite Structures

    DEFF Research Database (Denmark)

    Giversen, Søren

    The motivation for this work is based on a desire for finding light weight alternatives to high strength steel as the material to use for armouring in military vehicles. With the use of high strength steel, an increase in the level of armouring has a significant impact on the vehicle weight......-up proved functional and provided consistent data of the panel response. The tests reviled that the sandwich panels did not provide a decrease in panel deflection compared with the monolithic laminates, which was expected due to their higher flexural rigidity. This was found to be because membrane effects...... a pressure distribution on a selected surfaces and has been based on experimental pressure measurement data, and (ii) with a designed 3 step numerical load model, where the blast pressure and FSI (Fluid Structure Interaction) between the pressure wave and modelled panel is modelled numerically. The tested...

  15. The open blast pelvis: the significant burden of management.

    Science.gov (United States)

    Ramasamy, A; Evans, S; Kendrew, J M; Cooper, J

    2012-06-01

    The open blast fracture of the pelvis is considered to be the most severe injury within the spectrum of battlefield trauma. We report our experience of 29 consecutive patients who had sustained this injury in Afghanistan between 2008 and 2010. Their median new injury severity score (NISS) was 41 (8 to 75), and mean blood requirement in the first 24 hours was 60.3 units (0 to 224). In addition to their orthopaedic injury, six had an associated vascular injury, seven had a bowel injury, 11 had a genital injury and seven had a bladder injury. In all, eight fractures were managed definitively with external fixation and seven required internal fixation. Of those patients who underwent internal fixation, four required removal of metalwork for infection. Faecal diversion was performed in nine cases. The median length of hospital stay following emergency repatriation to the United Kingdom was 70.5 days (5 to 357) and the mean total operating time was 29.6 hours (5 to 187). At a mean follow-up of 20.3 months (13.2 to 29.9), 24 patients (82.8%) were able to walk and 26 (89.7%) had clinical and radiological evidence of stability of the pelvic ring. As a result of the increase in terrorism, injuries that were previously confined exclusively to warfare can now occur anywhere, with civilian surgeons who are involved in trauma care potentially required to manage similar injuries. Our study demonstrates that the management of this injury pattern demands huge resources and significant multidisciplinary input. Given the nature of the soft-tissue injury, we would advocate external fixation as the preferred management of these fractures. With the advent of emerging wound and faecal management techniques, we do not believe that faecal diversion is necessary in all cases.

  16. Characterization of viscoelastic materials for low-magnitude blast mitigation

    Science.gov (United States)

    Bartyczak, S.; Mock, W.

    2014-05-01

    Recent research indicates that exposure to low amplitude blast waves, such as IED detonation or multiple firings of a weapon, causes damage to brain tissue resulting in Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD). Current combat helmets are not sufficiently protecting warfighters from this danger and the effects are debilitating, costly, and long-lasting. The objective of the present work is to evaluate the blast mitigating behavior of current helmet materials and new materials designed for blast mitigation using a test fixture recently developed at the Naval Surface Warfare Center Dahlgren Division for use with an existing gas gun. The 40-mm-bore gas gun was used as a shock tube to generate blast waves (ranging from 0.5 to 2 bar) in the test fixture mounted on the gun muzzle. A fast opening valve was used to release helium gas from the breech which formed into a blast wave and impacted instrumented targets in the test fixture. Blast attenuation of selected materials was determined through the measurement of stress data in front of and behind the target. Materials evaluated in this research include polyurethane foam from currently fielded US Army and Marine Corps helmets, polyurea 1000, and three hardnesses of Sorbothane (48, 58, and 70 durometer, Shore 00). Polyurea 1000 and 6061-T6 aluminum were used to calibrate the stress gauges.

  17. The Potential ofStreptomycesas Biocontrol Agents against the Rice Blast Fungus,Magnaporthe oryzae(Pyricularia oryzae).

    Science.gov (United States)

    Law, Jodi Woan-Fei; Ser, Hooi-Leng; Khan, Tahir M; Chuah, Lay-Hong; Pusparajah, Priyia; Chan, Kok-Gan; Goh, Bey-Hing; Lee, Learn-Han

    2017-01-01

    Rice is a staple food source for more than three billion people worldwide. However, rice is vulnerable to diseases, the most destructive among them being rice blast, which is caused by the fungus Magnaporthe oryzae (anamorph Pyricularia oryzae ). This fungus attacks rice plants at all stages of development, causing annual losses of approximately 10-30% in various rice producing regions. Synthetic fungicides are often able to effectively control plant diseases, but some fungicides result in serious environmental and health problems. Therefore, there is growing interest in discovering and developing new, improved fungicides based on natural products as well as introducing alternative measures such as biocontrol agents to manage plant diseases. Streptomyce s bacteria appear to be promising biocontrol agents against a wide range of phytopathogenic fungi, which is not surprising given their ability to produce various bioactive compounds. This review provides insight into the biocontrol potential of Streptomyces against the rice blast fungus, M. oryzae . The ability of various S treptomyces spp. to act as biocontrol agents of rice blast disease has been studied by researchers under both laboratory and greenhouse/growth chamber conditions. Laboratory studies have shown that Streptomyces exhibit inhibitory activity against M. oryzae . In greenhouse studies, infected rice seedlings treated with Streptomyces resulted in up to 88.3% disease reduction of rice blast. Studies clearly show that Streptomyces spp. have the potential to be used as highly effective biocontrol agents against rice blast disease; however, the efficacy of any biocontrol agent may be affected by several factors including environmental conditions and methods of application. In order to fully exploit their potential, further studies on the isolation, formulation and application methods of Streptomyces along with field experiments are required to establish them as effective biocontrol agents.

  18. The design and construction of the bottom working for in-situ leaching of fragmented uranium ore by blasting in No. 745 mine

    International Nuclear Information System (INIS)

    Ding Dexin; Yang Shijiao; Li Ming

    1998-11-01

    Bottom working is a very important structure for in-situ leaching of fragmented uranium ore by blasting. Its design and construction should simultaneously satisfy the requirements for receiving fragmented ore, transporting the ore, providing relief space for blast operation, passage for workers and fresh air for the slope and collecting the pregnant solution from spraying over the fragmented ore. The author deals with the design and construction of the complete water cutoff bottom working for collecting the pregnant solution for in-situ leaching of fragmented uranium ore by long hole blast in No. 745 mine in Guangdong Province. The preparation system for the block, the undercutting, the construction process and method of the bottom working and the measures to guide the solution leaked into the surrounding rock mass to the bottom of the block are described in detail

  19. Soft tissue and wound management of blast injuries.

    Science.gov (United States)

    Sheean, Andrew J; Tintle, Scott M; Rhee, Peter C

    2015-09-01

    The management of blast-related soft tissue wounds requires a comprehensive surgical approach that acknowledges extensive zones of injury and the likelihood of massive contamination. The experiences of military surgeons during the last decade of war have significantly enhanced current understandings of the optimal means of mitigating infectious complications, the timing of soft tissue coverage attempts, and the reconstructive options available for definitive wound management. Early administration of antibiotics in the setting of soft tissue wounds and associated open fractures is the single most important aspect of open fracture care. Both civilian and military reports have elucidated the incidence of invasive fungal infection in the setting of high-energy injuries with significant wound burdens, and novel treatment protocols have emerged. The type of reconstruction is predicated upon the zone of injury and location of the soft tissue defect. Multiple reports of military cohorts have suggested the equivalency of various techniques and types of soft tissue coverage. Longer-term follow-up will inform future perspectives on the durability of these surgical approaches.

  20. H-BLAST: a fast protein sequence alignment toolkit on heterogeneous computers with GPUs.

    Science.gov (United States)

    Ye, Weicai; Chen, Ying; Zhang, Yongdong; Xu, Yuesheng

    2017-04-15

    The sequence alignment is a fundamental problem in bioinformatics. BLAST is a routinely used tool for this purpose with over 118 000 citations in the past two decades. As the size of bio-sequence databases grows exponentially, the computational speed of alignment softwares must be improved. We develop the heterogeneous BLAST (H-BLAST), a fast parallel search tool for a heterogeneous computer that couples CPUs and GPUs, to accelerate BLASTX and BLASTP-basic tools of NCBI-BLAST. H-BLAST employs a locally decoupled seed-extension algorithm for better performance on GPUs, and offers a performance tuning mechanism for better efficiency among various CPUs and GPUs combinations. H-BLAST produces identical alignment results as NCBI-BLAST and its computational speed is much faster than that of NCBI-BLAST. Speedups achieved by H-BLAST over sequential NCBI-BLASTP (resp. NCBI-BLASTX) range mostly from 4 to 10 (resp. 5 to 7.2). With 2 CPU threads and 2 GPUs, H-BLAST can be faster than 16-threaded NCBI-BLASTX. Furthermore, H-BLAST is 1.5-4 times faster than GPU-BLAST. https://github.com/Yeyke/H-BLAST.git. yux06@syr.edu. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  1. Partitioning of a scaled shallow-buried near-field blast load

    CSIR Research Space (South Africa)

    Reinecke, J

    2015-07-01

    Full Text Available Buried blast threats have been used for many years in both conventional and unconventional warfare. They are cheap, easily hidden, remain viable for extremely long periods after deployment and are effective, focusing the resulting blast products...

  2. Investigation of accretion formation in a blast furnace shaft

    Energy Technology Data Exchange (ETDEWEB)

    Klima, R.; Hoefer, O.; Chiarotti, U.; Fredman, T.; Hillmann, C.; Raipala, K.; Eriksson, J. (eds.) [BFI Duesseldorf (Germany)

    2005-07-01

    Accretions in the bosh, belly and shaft have a significant influence on blast furnace performance and on the service life of the refractory lining and the cooling system. To analyse the mechanisms of formation and dislodging of accretions, investigations were carried out at four different blast furnaces. Three blast furnaces were equipped with additional measurements to investigate the accretion formation process and to provide information for the development of accretion estimation models. Installation activities included thermocouples, heat-flux meters, staves with instrumentation for heat-flux measurement and a small horizontal lance. The distribution of accretions in the shaft was documented. Samples were taken out of accretions during blast furnace stoppages. Their acquisition was simplified with newly developed sampling devices. The samples were analysed to determine chemical and mineralogical properties and thermal conductivity. Samples were mainly made up of reduced iron or of coke and sinter structures glued together by zinc or alkali compounds. Together with a newly developed offline model for the simulation of accretion formation, different parameters influencing the formation process were identified. The main parameters are: burden material composition, blast furnace operating conditions; and the cooling system. Countermeasures to prevent excessive accretion growth were determined. They offer a better operational control of accretions. Different models to identify accretion formation were developed and an overview was presented. Different models were necessary to distinguish between the various measurement, cooling-system and blast-furnace setups. Most of the models are already implemented and in operational use. For some of them application at other blast furnaces was already realised or is possible. 9 refs., 18 figs., 20 tab.

  3. Inducible Expression of Agrobacterium Virulence Gene VirE2 for Stringent Regulation of T-DNA Transfer in Plant Transient Expression Systems.

    Science.gov (United States)

    Denkovskienė, Erna; Paškevičius, Šarūnas; Werner, Stefan; Gleba, Yuri; Ražanskienė, Aušra

    2015-11-01

    Agrotransfection with viral vectors is an effective solution for the transient production of valuable proteins in plants grown in contained facilities. Transfection methods suitable for field applications are desirable for the production of high-volume products and for the transient molecular reprogramming of plants. The use of genetically modified (GM) Agrobacterium strains for plant transfections faces substantial biosafety issues. The environmental biosafety of GM Agrobacterium strains could be improved by regulating their T-DNA transfer via chemically inducible expression of virE2, one of the essential Agrobacterium virulence genes. In order to identify strong and stringently regulated promoters in Agrobacterium strains, we evaluated isopropyl-β-d-thiogalactoside-inducible promoters Plac, Ptac, PT7/lacO, and PT5/lacOlacO and cumic acid-inducible promoters PlacUV5/CuO, Ptac/CuO, PT5/CuO, and PvirE/CuO. Nicotiana benthamiana plants were transfected with a virE2-deficient A. tumefaciens strain containing transient expression vectors harboring inducible virE2 expression cassettes and containing a marker green fluorescent protein (GFP) gene in their T-DNA region. Evaluation of T-DNA transfer was achieved by counting GFP expression foci on plant leaves. The virE2 expression from cumic acid-induced promoters resulted in 47 to 72% of wild-type T-DNA transfer. Here, we present efficient and tightly regulated promoters for gene expression in A. tumefaciens and a novel approach to address environmental biosafety concerns in agrobiotechnology.

  4. Evaluating the Effectiveness of Various Blast Loading Descriptors as Occupant Injury Predictors for Underbody Blast Events

    Science.gov (United States)

    2014-01-09

    t:N , CFC # Pulse type Dec. g ion ms al ms m/s Sp. Pwr Eff. G G- ava @2ms @Oms @15ms 1000 @3ms @7ms @7ms @30ms @Oms 1 Triangular 44 40 2 8.6 376 27 22...Power, Blast, ROM, reduced order models, MADYMO, occupant, injury, pulse , loading, descriptor, calculator 16. SECURITY CLASSIFICATION OF: 17... pulse and occupant injury It has been shown before that there is no single input parameter which can be used to effectively assess occupant injury

  5. ORGANISATIONAL-TECHNOLOGICAL CHARACTERISTICS OF BLASTING WORKS ON THE GRIČ TUNNEL

    OpenAIRE

    Zvonimir Deković; Zvonimir Ester; Mario Dobrilović

    2005-01-01

    The paper describes organisational-technological characteristics of blasting works during the excavation of the Grič Tunnel. The significance of blasting works during the excavation of the tunnel is shown through adjustment of blasting parameters taking into consideration the dynamics of the works, cost-effectiveness and influence of geological circumstances. Successfulness of blasting directly influences the subsequent tunnel excavation cycle both in terms of duration as well as eventually i...

  6. Controlled blasting and its implications for the NNWSI project exploratory shaft

    International Nuclear Information System (INIS)

    Van Eeckhout, E.M.

    1987-09-01

    This report reviews controlled blasting techniques for shaft sinking. Presplitting and smooth blasting are the techniques of principal interest. Smooth blasting is preferred for the Nevada Nuclear Waste Storage Investigations exploratory shaft. Shaft damage can be monitored visually or by peak velocity measurements and refractive techniques. Damage into the rock should be limited to 3 ft. 40 refs., 22 figs., 7 tabs

  7. 29 CFR 1926.904 - Storage of explosives and blasting agents.

    Science.gov (United States)

    2010-07-01

    ..., electric blasting caps, detonating primers, and primed cartridges shall not be stored in the same magazine... feet of explosives and detonator storage magazine. (d) No explosives or blasting agents shall be... 29 Labor 8 2010-07-01 2010-07-01 false Storage of explosives and blasting agents. 1926.904 Section...

  8. Blast tests of expedient shelters in the DICE THROW event

    International Nuclear Information System (INIS)

    Kearny, C.H.; Chester, C.V.

    1978-03-01

    To determine the worst blast environments that eight types of expedient shelters can withstand, we subjected a total of 18 shelters to the 1-kiloton blast effects of Defense Nuclear Agency's DICE THROW main event. These expedient shelters included two Russian and two Chinese types. The best shelter tested was a Small-Pole Shelter that had a box-like room of Russian design with ORNL-designed expedient blast entries and blast doors added. It was undamaged at the 53-psi peak overpressure range; the pressure rise inside was only 1.5 psi. An unmodified Russian Pole-Covered Trench Shelter was badly damaged at 6.8 psi. A Chinese ''Man'' Shelter, which skillfully uses very small poles to attain protective earth arching, survived 20 psi, undamaged. Two types of expedient shelters built of materials found in and around most American homes gave good protection at overpressures up to about 6 psi. Rug-Covered Trench Shelters were proved unsatisfactory. Water storage pits lined with ordinary plastic trash bags were proven practical at up to 53 psi, as were triangular expedient blast doors made of poles

  9. Modelling of turbulent combustion in the blast furnace raceway

    Energy Technology Data Exchange (ETDEWEB)

    Karvinen, R.; Maekiranta, R. [Tampere Univ. (Finland). Energy and Process Engineering

    1996-12-31

    The phenomena concerning coke-gas -suspension and simultaneous combustion of solid coke particles and residual fuel oil in a blast furnace raceway are modelled. The flow field of suspension is predicted by using the two fluid model, which is based on the Eulerian method, in the Phoenics code. The standard k-e -model of turbulence is used. Pyrolysis of oil droplets is calculated with the own coded subroutine, which is based on the Lagrangian approach. Gas phase reaction rate is assumed to be controlled by chemical kinetics. Radiative heat transfer is calculated by using the six-flux method. Heterogenous surface reactions are used for the coke particles. Calculations without coke combustion show that due to a poor mixing in the hot blast, pyrolysis gases of residual fuel oil have not time enough to react with oxygen. It is obvious that if combustion of coke particles is taken into account, the oxygen content in the blast decreases to such a level, that unburnt pyrolysis gases can flow out of the raceway causing problems. The distribution of coke void fraction has been succeeded to predict in the raceway domain. Coke particles fall from the upper part of the raceway to the hot blast forming locally high concentrations, which affect very strongly the oxygen distribution of the hot blast. (orig.) SULA 2 Research Programme; 10 refs.

  10. TREATMENT OF LOW-BLAST COUNT AML USING HYPOMETHYLATING AGENTS

    Directory of Open Access Journals (Sweden)

    Eleonora De Bellis

    2017-07-01

    Full Text Available In 2002, the WHO classification reduced the proportion of blasts in the bone marrow (BM necessary for the diagnosis of acute myeloid leukemia (AML from 30% to 20%, eliminating the RAEB-t subtype of myelodysplastic syndromes (MDS. However, this AML subtype, defined as low-blast count AML (LBC-AML, with 20-30% BM-blasts is characterized by peculiar features, as increased frequency in elderly individuals and after cytotoxic treatment for a different primary disease (therapy-related, poor-risk cytogenetics, lower white blood cell counts, and less frequent mutations of NPM1 and FLT3 genes. The clinical course of this entity is often similar to MDS with 10-19% BM-blasts. The hypomethylating agents azacitidine and decitabine have been shown to induce responses and prolong survival both in MDS and LBC-AML.  The role of these agents has been also demonstrated in AML with >30% BM-blasts, particularly in patients with poor-risk cytogenetics and in AML with myelodysplasia related changes. Most recent studies are evaluating strategies to improve outcome, including combinations of hypomethylating agents with immune-response checkpoint inhibitors, which have a role in cancer immune surveillance. Efforts are also ongoing to identify mutations which may predict response and survival in these patients.

  11. Analysis of MINIE2013 Explosion Air-Blast Data

    Energy Technology Data Exchange (ETDEWEB)

    Schnurr, Julie M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of Hawaii, Manoa, HI (United States); Rodgers, Arthur J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, Keehoon [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ford, Sean R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ramirez, Abelardo L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-10-14

    We report analysis of air-blast overpressure measurements from the MINIE2013 explosive experiments. The MINIE2013 experiment involved a series of nearly 70 near-surface (height-ofburst, HOB, ranging from -1 to +4 m) low-yield (W=2-20 kg TNT equivalent) chemical highexplosives tests that were recorded at local distances (230 m – 28.5 km). Many of the W and HOB combinations were repeated, allowing for quantification of the variability in air-blast features and corresponding yield estimates. We measured canonical signal features (peak overpressure, impulse per unit area, and positive pulse duration) from the air-blast data and compared these to existing air-blast models. Peak overpressure measurements showed good agreement with the models at close ranges but tended to attenuate more rapidly at longer range (~ 1 km), which is likely caused by upward refraction of acoustic waves due to a negative vertical gradient of sound speed. We estimated yields of the MINIE2013 explosions using the Integrated Yield Determination Tool (IYDT). Errors of the estimated yields were on average within 30% of the reported yields, and there were no significant differences in the accuracy of the IYDT predictions grouped by yield. IYDT estimates tend to be lower than ground truth yields, possibly because of reduced overpressure amplitudes by upward refraction. Finally, we report preliminary results on a development of a new parameterized air-blast waveform.

  12. Diagrammatic scale for the assessment of blast on wheat spikes

    Directory of Open Access Journals (Sweden)

    João Leodato Nunes Maciel

    2013-09-01

    Full Text Available The correct quantification of blast caused by the fungus Magnaporthe oryzae on wheat (Triticum aestivum spikes is an important component to understand the development of this disease aimed at its control. Visual quantification based on a diagrammatic scale can be a practical and efficient strategy that has already proven to be useful against several plant pathosystems, including diseases affecting wheat spikes like glume blotch and fusarium head blight. Spikes showing different disease severity values were collected from a wheat field with the aim of elaborating a diagrammatic scale to quantify blast severity on wheat spikes. The spikes were photographed and blast severity was determined by using resources of the software ImageJ. A diagrammatic scale was developed with the following disease severity values: 3.7, 7.5, 21.4, 30.5, 43.8, 57.3, 68.1, 86.0, and 100.0%. An asymptomatic spike was added to the scale. Scale validation was performed by eight people who estimated blast severity by using digitalized images of 40 wheat spikes. The precision and the accuracy of the evaluations varied according to the rater (0.82blast on wheat spikes.

  13. Blasting vibrations control: The shortcomings of traditional methods

    Energy Technology Data Exchange (ETDEWEB)

    Vuillaume, P.M.; Kiszlo, M. [Institut National de l`Environnement Industriel et des Risques, Verneuil en Halatte (France); Bernard, T. [Compagnie Nouvelle de Scientifiques, Nice (France)

    1996-12-31

    In the context of its studies for the French ministry of the environment and for the French national coal board, INERIS (the French institute for the industrial environment and hazards, formerly CERCHAR) has made a complete critical survey of the methods generally used to reduce the levels of blasting vibrations. It is generally acknowledged that the main parameter to control vibrations is the so-called instantaneous charge, or charge per delay. This should be reduced as much as possible in order to diminish vibration levels. On account of this, the use of a new generation of blasting devices, such as non-electric detonators or electronic sequential timers has been developed since the seventies. INERIS has collected data from about 900 blasts in 2 quarries and 3 open pit mines. These data include input parameters such as borehole diameter, burden, spacing, charge per hole, charge per delay, total fired charge, etc ... They also include output measurements, such as vibration peak particle velocities, and main frequencies. These data have been analyzed with the help of multi variable statistical tools. Blasting tests were undertaken to evaluate new methods of vibrations control, such as the superposition of vibration signals. These methods appear to be accurate in many critical cases, but certainly would be highly improved with a better accuracy of firing delays. The development of electronic detonators seems to be the way of the future for a better blasting control.

  14. Impact of complex blast waves on the human head: a computational study.

    Science.gov (United States)

    Tan, Long Bin; Chew, Fatt Siong; Tse, Kwong Ming; Chye Tan, Vincent Beng; Lee, Heow Pueh

    2014-12-01

    Head injuries due to complex blasts are not well examined because of limited published articles on the subject. Previous studies have analyzed head injuries due to impact from a single planar blast wave. Complex or concomitant blasts refer to impacts usually caused by more than a single blast source, whereby the blast waves may impact the head simultaneously or consecutively, depending on the locations and distances of the blast sources from the subject, their blast intensities, the sequence of detonations, as well as the effect of blast wave reflections from rigid walls. It is expected that such scenarios will result in more serious head injuries as compared to impact from a single blast wave due to the larger effective duration of the blast. In this paper, the utilization of a head-helmet model for blast impact analyses in Abaqus(TM) (Dassault Systemes, Singapore) is demonstrated. The model is validated against studies published in the literature. Results show that the skull is capable of transmitting the blast impact to cause high intracranial pressures (ICPs). In addition, the pressure wave from a frontal blast may enter through the sides of the helmet and wrap around the head to result in a second impact at the rear. This study recommended better protection at the sides and rear of the helmet through the use of foam pads so as to reduce wave entry into the helmet. The consecutive frontal blasts scenario resulted in higher ICPs compared with impact from a single frontal blast. This implied that blast impingement from an immediate subsequent pressure wave would increase severity of brain injury. For the unhelmeted head case, a peak ICP of 330 kPa is registered at the parietal lobe which exceeds the 235 kPa threshold for serious head injuries. The concurrent front and side blasts scenario yielded lower ICPs and skull stresses than the consecutive frontal blasts case. It is also revealed that the additional side blast would only significantly affect ICPs at

  15. Exergo-Ecological Assessment Of Auxiliary Fuel Injection Into Blast-Furnace

    Directory of Open Access Journals (Sweden)

    Stanek W.

    2015-06-01

    Full Text Available Metallurgy represents complex technological chain supplied with different kinds of primary resources. Iron metallurgy based on blast-furnace process, dominates in world steel production. Metallurgical coke is the basic fuel in this case. Its production is connected with several environmental disadvantageous impacts. One of them is the extended production chain from primary energy to final energy. The reduction of coke consumption in the process can be achieved e.g. by injection of auxiliary fuels or increasing the thermal parameters in the process. In present injection of pulverised coal dominates while recirculation of top-gas seems to be future technology. However, the latter one requires the CO2 removal that additionally extended the production chain. The evaluation of resources management in complex energy-technological systems required application of advanced method based on thermodynamics. In the paper the system exergo-ecological assessment of pulverised coal injection into blast-furnace and top-gas recirculation has been applied. As a comparative criterion the thermo-ecological cost has been proposed.

  16. 77 FR 49277 - Takes of Marine Mammals During Specified Activities; Confined Blasting Operations by the U.S...

    Science.gov (United States)

    2012-08-15

    ... effects that confined blasting can have on marine animals near the blast (Keevin et al., 1999). The visual... Atmospheric Administration Takes of Marine Mammals During Specified Activities; Confined Blasting Operations... Marine Mammals During Specified Activities; Confined Blasting Operations by the U.S. Army Corps of...

  17. COLLIMATION AND ASYMMETRY OF THE HOT BLAST WAVE FROM THE RECURRENT NOVA V745 Sco

    Energy Technology Data Exchange (ETDEWEB)

    Drake, Jeremy J.; Kashyap, Vinay [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Delgado, Laura; Hernanz, M. [Institute of Space Sciences, ICE (CSIC-IEEC), E-08193 Cerdanyola del Vallés, Barcelona (Spain); Laming, J. Martin [Space Science Division, Naval Research Laboratory, Code 7674L, Washington, DC 20375 (United States); Starrfield, Sumner [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1404 (United States); Orlando, Salvatore [INAF—Osservatorio Astronomico di Palermo G. S. Vaiana, Piazza del Parlamento 1, I-90134 Palermo (Italy); Page, Kim L. [Department of Physics and Astronomy, University of Leicester, Leicester, LE1 7RH (United Kingdom); Ness, J.-U. [Science Operations Division, Science Operations Department of ESA, ESAC, E-28691 Villanueva de la Cañada (Madrid) (Spain); Gehrz, R. D.; Woodward, Charles E. [Minnesota Institute for Astrophysics, School of Physics and Astronomy, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455 (United States); Van Rossum, Daan [Flash Center for Computational Science, Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States)

    2016-07-10

    The recurrent symbiotic nova V745 Sco exploded on 2014 February 6 and was observed on February 22 and 23 by the Chandra X-ray Observatory Transmission Grating Spectrometers. By that time the supersoft source phase had already ended, and Chandra spectra are consistent with emission from a hot, shock-heated circumstellar medium with temperatures exceeding 10{sup 7} K. X-ray line profiles are more sharply peaked than expected for a spherically symmetric blast wave, with a full width at zero intensity of approximately 2400 km s{sup 1}, an FWHM of 1200 ± 30 km s{sup 1}, and an average net blueshift of 165 ± 10 km s{sup 1}. The red wings of lines are increasingly absorbed toward longer wavelengths by material within the remnant. We conclude that the blast wave was sculpted by an aspherical circumstellar medium in which an equatorial density enhancement plays a role, as in earlier symbiotic nova explosions. Expansion of the dominant X-ray-emitting material is aligned close to the plane of the sky and is most consistent with an orbit seen close to face-on. Comparison of an analytical blast wave model with the X-ray spectra, Swift observations, and near-infrared line widths indicates that the explosion energy was approximately 10{sup 43} erg and confirms an ejected mass of approximately 10{sup 7} M {sub ⊙}. The total mass lost is an order of magnitude lower than the accreted mass required to have initiated the explosion, indicating that the white dwarf is gaining mass and is a Type Ia supernova progenitor candidate.

  18. Numerical simulation of the fluid-structure interaction between air blast waves and soil structure

    Science.gov (United States)

    Umar, S.; Risby, M. S.; Albert, A. Luthfi; Norazman, M.; Ariffin, I.; Alias, Y. Muhamad

    2014-03-01

    Normally, an explosion threat on free field especially from high explosives is very dangerous due to the ground shocks generated that have high impulsive load. Nowadays, explosion threats do not only occur in the battlefield, but also in industries and urban areas. In industries such as oil and gas, explosion threats may occur on logistic transportation, maintenance, production, and distribution pipeline that are located underground to supply crude oil. Therefore, the appropriate blast resistances are a priority requirement that can be obtained through an assessment on the structural response, material strength and impact pattern of material due to ground shock. A highly impulsive load from ground shocks is a dynamic load due to its loading time which is faster than ground response time. Of late, almost all blast studies consider and analyze the ground shock in the fluid-structure interaction (FSI) because of its influence on the propagation and interaction of ground shock. Furthermore, analysis in the FSI integrates action of ground shock and reaction of ground on calculations of velocity, pressure and force. Therefore, this integration of the FSI has the capability to deliver the ground shock analysis on simulation to be closer to experimental investigation results. In this study, the FSI was implemented on AUTODYN computer code by using Euler-Godunov and the arbitrary Lagrangian-Eulerian (ALE). Euler-Godunov has the capability to deliver a structural computation on a 3D analysis, while ALE delivers an arbitrary calculation that is appropriate for a FSI analysis. In addition, ALE scheme delivers fine approach on little deformation analysis with an arbitrary motion, while the Euler-Godunov scheme delivers fine approach on a large deformation analysis. An integrated scheme based on Euler-Godunov and the arbitrary Lagrangian-Eulerian allows us to analyze the blast propagation waves and structural interaction simultaneously.

  19. THE Blast-Wave-Driven Instability as a Vehicle for Understanding Supernova Explosion Structure

    Science.gov (United States)

    Miles, Aaron R.

    2009-05-01

    Blast-wave-driven instabilities play a rich and varied role in supernovae (SNe) evolution from explosion to remnant, but interpreting their role is difficult due to the enormous complexity of stellar systems. We consider the simpler idealized problem of an interface between two constant-density fluids perturbed from spherical and driven by a central blast wave. Where valid, the existence of unified solutions suggests that general conclusions can be drawn about the likely asymptotic structure of the mixing zone. To this end, we apply buoyancy-drag and bubble merger models that include effects of divergence and compressibility. In general, these effects preclude the true self-similar evolution of classical Rayleigh-Taylor (RT), but can be incorporated into a quasi-self-similar growth model. Loss of memory of initial conditions (ICs) can occur in the model, but requires pre-explosion mode numbers higher than predicted for Type II SNe, suggesting that their late-time structure is influenced by details of the initial perturbations. Where low modes dominate, as in the Type Ia Tycho remnant, they result from initial perturbations rather than generation from smaller scales. Therefore, the structure observed now contains direct information about the explosion process. When large-amplitude modes exist in the ICs, the contribution from the Richtmyer-Meshkov (RM) instability is significant compared to RT. Such RM growth can yield proximity of the forward shock to the growing spikes and structure that strongly resembles that observed in Tycho. Laser-driven laboratory experiments offer a promising avenue for testing model and simulation descriptions of blast-wave-driven instabilities and making connections to their astrophysical counterparts.

  20. Thermal analysis evaluation of the reactivity of coal mixtures for injection in the blast furnace

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Ilha Gomes

    2006-03-01

    Full Text Available Pulverized Coal Injection (PCI is an important standard technology replacing coke partially by pulverized coal into the blast furnace that allows a significant reduction of hot metal costs and environmental impact, contributing to a decrease of coke requirements for ironmaking. Coals typically used in this process in Brazil are, at current time, exclusively imported from many countries, although economic important coal-measures occur in the southern part of the country. The Brazilian coals have a low rank, higher contents of inert components, proportioning nocoking properties and an expected high reactivity. Due to these caractheristics, these coals could be used for injection in the blast furnaces in order to decrease the dependency on high cost imported coals. The efficiency in the combustion and the coal reactivity are considered important parameters in the blast furnace, since a larger amount of char (unburned coal causes severe problems to the furnace operation. The aim of the present work is to compare the reactivity of a south Brazilian coal, obtained from Faxinal mine, with two imported coals and the blends of the Brazilian coal with the imported ones. The reactivity of these coals and their blends were evaluated in a thermogravimetric analyzer. In the experiments, various mass ratios of Faxinal coal and the imported coals were used to compose the blends. The gasification reaction with pure CO2 was conducted under isothermal conditions at 1050 °C and atmospheric pressure. The experimental results show the greater reactivity of the Faxinal coal. The additive behavior was confirmed. The blends with a composition of up to 50% Faxinal coal have parameters according to the usual limits used for PCI.

  1. CO{sub 2} pellet blasting literature search and decontamination scoping tests report

    Energy Technology Data Exchange (ETDEWEB)

    Archibald, K.E.

    1993-12-01

    Past decontamination and solvent recovery activities at the Idaho Chemical Processing Plant (ICPP) have resulted in the accumulation of 1.5 million gallons of radioactively contaminated sodium-bearing liquid waste. Future decontamination activities at the ICPP could result in the production of 5 million gallons or more of sodium-bearing waste using current decontamination techniques. Chemical decontamination flushes have provided a satisfactory level of decontamination. However, this method generates large amounts of sodium-bearing secondary waste. Steam jet cleaning has also been used with a great deal of success but cannot be used on concrete or soft materials. With the curtailment of reprocessing at the ICPP, the focus of decontamination is shifting from maintenance for continued operation of the facilities to decommissioning. Treatment of sodium-bearing waste is a particularly difficult problem due to the high content of alkali metals in the sodium-bearing liquid waste. It requires a very large volume of cold chemical additive for calcination. In addition, the sodium content of the sodium-bearing waste exceeds the limit that can be incorporated into vitrified waste without the addition of glass-forming compounds (primarily silicon) to produce an acceptable immobilized waste form. The primary initiatives of the Decontamination Development Program is the development of methods to eliminate/minimize the use of sodium-bearing decontamination chemicals and to minimize all liquid decontamination wastes. One method chosen for cold scoping studies during FY-93 was CO{sub 2} pellet blasting. CO{sub 2} pellet blasting has been used extensively by commercial industries for general cleaning. However, using this method for decontamination of nuclear materials is a fairly new concept. The following report discusses the research and scoping tests completed on CO{sub 2} pellet blasting.

  2. Superficial characterization of titanium league when submitted to abrasive blasting

    International Nuclear Information System (INIS)

    Suzuki, L.Y.; Leite, I.V.; Szesz, E.M.; Siqueira, C.J.M.

    2010-01-01

    Commercially pure titanium and some of its alloys exhibit a good biocompatibility. These characteristics are frequently used in the manufacture of orthopedic and dental implants. It is possible to modify its surface making it the bioactive using various methods, such as deposition of hydroxyapatite by plasma spray and increasing the roughness of the surface by abrasive blasting. This work is to modify the surface of titanium alloy Ti6Al4V ELI (ASTM F136: 02a) for abrasive blasting and study the morphology, crystallographic phases and the mechanical characteristics of the surface obtained. For such purpose, SEM images, diffraction of X-rays and tests of risk produced by nanoindenter. The sandblasting was done using alumina powder and blasting time of 6s. The morphology of the surfaces of Ti6Al4V ELI changed after sandblasting with increased roughness. It is possible to conclude that after sandblasting the titanium surface do not have a ductile behavior. (author)

  3. Thermal valorisation of automobile shredder residue: injection in blast furnace.

    Science.gov (United States)

    Mirabile, Daphne; Pistelli, Maria Ilaria; Marchesini, Marina; Falciani, Roberta; Chiappelli, Lisa

    2002-01-01

    Wastes with residual heating value, according to the trend of the world legislation, could be thermally reused. The present study is conducted to verify the possibility of thermal valorisation of a waste, denominated fluff, by injection in blast furnace. The fluff, arising from the automobile shredder operations, is a waste characterised by a high organic matrix and is potentially dangerous due to the heavy metals, oils filter and halogenated plastics content. The first step of the work is the chemical, physical and toxicological characterisation of this material. Then the fluff injection in a blast furnace tuyere is theoretically analysed with a mathematical model. Finally, experimental trials are conducted in a pilot plant, simulating the most important part of the blast furnace: the raceway, in order to analyse process and industrial aspects. In view of an industrial application a first economical evaluation is carried out on the basis of model and experimental results.

  4. Strain Rate Effects in CFRP Used For Blast Mitigation

    Directory of Open Access Journals (Sweden)

    Sarah. L. Orton

    2014-04-01

    Full Text Available The purpose of this research is to gain a better understanding of strain rate effects in carbon fiber reinforced polymer (CFRP laminates exposed to blast loading. The use of CFRP offers an attractive option for mitigating structures exposed to blasts. However, the effect of high strain rates in CFRP composites commonly used in the civil industry is unknown. This research conducted tensile tests of 21 CFRP coupons using a hydraulically powered dynamic loader. The strain rates ranged from 0.0015 s−1 to 7.86 s−1 and are representative of strain rates that CFRP may see in a blast when used to strengthen reinforced concrete structures. The results of the testing showed no increase in the tensile strength or stiffness of the CFRP at the higher strain rates. In addition, the results showed significant scatter in the tensile strengths possibly due to the rate of loading or manufacture of the coupon.

  5. Radiometric report for a blast furnace tracing with radioactive isotopes

    International Nuclear Information System (INIS)

    Tanase, G.; Tanase, M.

    1995-01-01

    One of the methods to monitor refractory wall of blast furnace is its tracing with radioactive isotopes. The tracer isotope can be detected by two ways: the external dosimetric measurement at the armour of the blast furnace and/or the radiometric measurement of the iron sample charge by charge. Any change in radiometric situation of tracer radioisotope is recorded in a radiometric report. This paper presents an original concept of radiometric report based upon PARADOX and CORELDRAW soft kits. Their advantage are: quick and easy changes, easy recording of current radioactivity of tracer isotope, short history of changes, visual mapping of the tracer isotope and others. In this way we monitored 6 blast furnaces and more than 180 radioactive sources

  6. Blast venting through blanket material in the HYLIFE ICF reactor

    International Nuclear Information System (INIS)

    Liu, J.C.; Peterson, P.F.; Schrock, V.E.

    1992-01-01

    This work presents a numerical study of blast venting through various blanket configurations in the HYLIFE ICF reactor design. The study uses TSUNAMI -- a multi-dimensional, high-resolution, shock capturing code -- to predict the momentum exchange and gas dynamics for blast venting in complex geometries. In addition, the study presents conservative predictions of wall loading by gas shock and impulse delivered to the protective liquid blanket. Configurations used in the study include both 2700 MJ and 350 MJ fusion yields per pulse for 5 meter and 3 meter radius reactor chambers. For the former, an annular jet array is used for the blanket geometry, while in the latter, both annular jet array as well as slab geometries are used. Results of the study indicate that blast venting and wall loading may be manageable in the HYLIFE-II design by a judicious choice of blanket configuration

  7. Face shield design against blast-induced head injuries.

    Science.gov (United States)

    Tan, Long Bin; Tse, Kwong Ming; Tan, Yuan Hong; Sapingi, Mohamad Ali Bin; Tan, Vincent Beng Chye; Lee, Heow Pueh

    2017-12-01

    Blast-induced traumatic brain injury has been on the rise in recent years because of the increasing use of improvised explosive devices in conflict zones. Our study investigates the response of a helmeted human head subjected to a blast of 1 atm peak overpressure, for cases with and without a standard polycarbonate (PC) face shield and for face shields comprising of composite PC and aerogel materials and with lateral edge extension. The novel introduction of aerogel into the laminate face shield is explored and its wave-structure interaction mechanics and performance in blast mitigation is analysed. Our numerical results show that the face shield prevented direct exposure of the blast wave to the face and help delays the transmission of the blast to reduce the intracranial pressures (ICPs) at the parietal lobe. However, the blast wave can diffract and enter the midface region at the bottom and side edges of the face shield, resulting in traumatic brain injury. This suggests that the bottom and sides of the face shield are important regions to focus on to reduce wave ingress. The laminated PC/aerogel/PC face shield yielded higher peak positive and negative ICPs at the frontal lobe, than the original PC one. For the occipital and temporal brain regions, the laminated face shield performed better than the original. The composite face shield with extended edges reduced ICP at the temporal lobe but increases ICP significantly at the parietal lobe, which suggests that a greater coverage may not lead to better mitigating effects. Copyright © 2017 John Wiley & Sons, Ltd.

  8. PaperBLAST: Text Mining Papers for Information about Homologs

    International Nuclear Information System (INIS)

    Price, Morgan N.; Arkin, Adam P.

    2017-01-01

    Large-scale genome sequencing has identified millions of protein-coding genes whose function is unknown. Many of these proteins are similar to characterized proteins from other organisms, but much of this information is missing from annotation databases and is hidden in the scientific literature. To make this information accessible, PaperBLAST uses EuropePMC to search the full text of scientific articles for references to genes. PaperBLAST also takes advantage of curated resources (Swiss-Prot, GeneRIF, and EcoCyc) that link protein sequences to scientific articles. PaperBLAST’s database includes over 700,000 scientific articles that mention over 400,000 different proteins. Given a protein of interest, PaperBLAST quickly finds similar proteins that are discussed in the literature and presents snippets of text from relevant articles or from the curators. With the recent explosion of genome sequencing data, there are now millions of uncharacterized proteins. If a scientist becomes interested in one of these proteins, it can be very difficult to find information as to its likely function. Often a protein whose sequence is similar, and which is likely to have a similar function, has been studied already, but this information is not available in any database. To help find articles about similar proteins, PaperBLAST searches the full text of scientific articles for protein identifiers or gene identifiers, and it links these articles to protein sequences. Then, given a protein of interest, it can quickly find similar proteins in its database by using standard software (BLAST), and it can show snippets of text from relevant papers. We hope that PaperBLAST will make it easier for biologists to predict proteins’ functions.

  9. Blast-induced damage:a summary of SveBeFo investigations

    OpenAIRE

    Saiang, David

    2008-01-01

    This report presents a summary of the blast damage investigation carried out by SveBeFo (Swedish Rock Engineering Research) during the period 1991 to 2003 at various hard rock sites in Sweden. The objective of this report is to present a synopsis of the important factors that influence the development and extent of the blast-induced damage zone, nature and characteristics of blast-induced fractures, and a summary of the blast-damage thickness with reference to the existing perimeter blasting ...

  10. ORGANISATIONAL-TECHNOLOGICAL CHARACTERISTICS OF BLASTING WORKS ON THE GRIČ TUNNEL

    Directory of Open Access Journals (Sweden)

    Zvonimir Deković

    2005-12-01

    Full Text Available The paper describes organisational-technological characteristics of blasting works during the excavation of the Grič Tunnel. The significance of blasting works during the excavation of the tunnel is shown through adjustment of blasting parameters taking into consideration the dynamics of the works, cost-effectiveness and influence of geological circumstances. Successfulness of blasting directly influences the subsequent tunnel excavation cycle both in terms of duration as well as eventually in terms of influence on the entire tunnel investment. Comparison of changes of basic blasting parameters during tunnel excavation ensured optimal excavation progress with minimal price per meter of tunnel progress.

  11. Windows .NET Network Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST

    Directory of Open Access Journals (Sweden)

    Oliver Melvin J

    2005-04-01

    Full Text Available Abstract Background BLAST is one of the most common and useful tools for Genetic Research. This paper describes a software application we have termed Windows .NET Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST, which enhances the BLAST utility by improving usability, fault recovery, and scalability in a Windows desktop environment. Our goal was to develop an easy to use, fault tolerant, high-throughput BLAST solution that incorporates a comprehensive BLAST result viewer with curation and annotation functionality. Results W.ND-BLAST is a comprehensive Windows-based software toolkit that targets researchers, including those with minimal computer skills, and provides the ability increase the performance of BLAST by distributing BLAST queries to any number of Windows based machines across local area networks (LAN. W.ND-BLAST provides intuitive Graphic User Interfaces (GUI for BLAST database creation, BLAST execution, BLAST output evaluation and BLAST result exportation. This software also provides several layers of fault tolerance and fault recovery to prevent loss of data if nodes or master machines fail. This paper lays out the functionality of W.ND-BLAST. W.ND-BLAST displays close to 100% performance efficiency when distributing tasks to 12 remote computers of the same performance class. A high throughput BLAST job which took 662.68 minutes (11 hours on one average machine was completed in 44.97 minutes when distributed to 17 nodes, which included lower performance class machines. Finally, there is a comprehensive high-throughput BLAST Output Viewer (BOV and Annotation Engine components, which provides comprehensive exportation of BLAST hits to text files, annotated fasta files, tables, or association files. Conclusion W.ND-BLAST provides an interactive tool that allows scientists to easily utilizing their available computing resources for high throughput and comprehensive sequence analyses. The install package for W.ND-BLAST is

  12. CFD‐DEM modelling of blast furnace tapping

    OpenAIRE

    Vango, Mathias; Pirker, Stefan; Lichtenegger, Thomas

    2017-01-01

    The campaign length of a blast furnace is limited by the hearth inner lining lifetime. In order to maximize the campaign length and ensure a good draining of hot metal and slag, a good understanding of the flow in the hearth is essential. Challenges in modelling the flow involve several continuous phases (hot metal, slag and hot blast) as well as the presence of the deadman, a dense bed of coke particles. The shape and position of the deadman depend on the weight of the burden column above an...

  13. Blasting preparation for selective mining of complex structured ore deposition

    Science.gov (United States)

    Marinin, M. A.; Dolzhikov, V. V.

    2017-10-01

    Technological features of ore mining in the open pit development for processing of complex structured ore deposit of steeply falling occurrence have been considered. The technological schemes of ore bodies mining under different conditions of occurrence, consistency and capacity have been considered and offered in the paper. These technologies permit to reduce losses and dilution, but to increase the completeness and quality of mined ore. A method of subsequent selective excavation of ore bodies has been proposed. The method is based on the complex use of buffer-blasting technology for the muck mass and the principle of trim blasting at ore-rock junctions.

  14. Brain Vulnerability to Repeated Blast Overpressure and Polytrauma

    Science.gov (United States)

    2014-11-01

    correlate with se- verity of diffuse brain injury in rats. Neurosurgery 56, 582–589. 23. Robertson, C.L., Saraswati, M., and Fiskum, G. (2007). Mitochondrial...were affected in 6/9 rats in the single blast group (average severi- ty =mild) versus 8/8 rats in the double blast group (average se- verity ...D.J., Pagulayan, K., McCraw, K., Hoff, D., Hart , K., Yu, C.E., Raskind, M.A., Cook, D.G., and Min- oshima, S. (2011). Cerebrocerebellar

  15. Brain Vulnerability to Repeated Blast Overpressure and Polytrauma

    Science.gov (United States)

    2015-10-01

    least four distinct forms of alkaline phosphatase nzyme present in mammals - intestinal, placental, placental- ike and TNAP (present in liver, bone...Mahota, T. M., Xu, L., Slack, N., Windle, D., and Ahmed, F. A. (2011). The patho- biology of blast injuries and blast- induced neurotrauma as...presence of 0.33 M of gene specific primers and 0.5 l of cDNA in thermal cycler as follows; 95 ◦C × 1 min, followed by 35 cycles of 95 ◦C × 30 s, 61 ◦C

  16. [Characteristics and Treatment Strategies for Penetrating Injuries on the Example of Gunshot and Blast Victims without Ballistic Body Armour in Afghanistan (2009 - 2013)].

    Science.gov (United States)

    Güsgen, Christoph; Willms, Arnulf; Richardsen, Ines; Bieler, Dan; Kollig, Erwin; Schwab, Robert

    2017-08-01

    significantly higher at 32.9%. Conclusion Patients without ballistic protection of the torso have high mortality rates, especially when suffering thoracoabdominal blast injuries. Blast injuries frequently lead to the DCS indication. The care of firearm and blast injury patients requires knowledge and competence in the damage control procedures for thorax and abdomen. Georg Thieme Verlag KG Stuttgart · New York.

  17. Retrospective review of lumbosacral dissociations in blast injuries.

    Science.gov (United States)

    Helgeson, Melvin D; Lehman, Ronald A; Cooper, Patrick; Frisch, Michael; Andersen, Romney C; Bellabarba, Carlo

    2011-04-01

    Retrospective review of medical records and radiographs. We assessed the clinical outcomes of lumbosacral dissociation (LSD) after traumatic, combat-related injuries, and to review our management of these distinct injuries and report our preliminary follow-up. LSD injuries are an anatomic separation of the pelvis from the spinal column, and are the result of high-energy trauma. A relative increase in these injuries has been seen in young healthy combat casualties subjected to high-energy blast trauma. We performed a retrospective review of inpatient/outpatient medical records and radiographs for all patients treated at our institution with combat-related lumbosacral dissociations. Twenty-three patients met inclusion criteria of combat-related lumbosacral dissociations with one-year follow-up. Patients were treated as follows: no fixation (9), sacroiliac screw fixation (8), posterior spinal fusion (5) and sacral plate (1). All patients with radiographic evidence of a zone III sacral fracture, in addition to associated lumbar fractures indicating loss of the iliolumbar ligamentous complex integrity were included. In 15 patients, the sacral fracture were an H or U type zone III fracture, whereas in the remaining nine, the sacral fracture was severely comminuted and unable to classify (six open fractures). There was no difference in visual analog scale (VAS) between treatment modalities. Two open injuries had residual infections. One patient treated with an L4-ilium posterior spinal fusion with instrumentation required instrumentation removal for infection. At a mean follow-up of 1.71 years (range, 1-4.5), 11 patients (48%) still reported residual pain and the mean VAS at latest follow-up was 1.7 (range, 0-7). Operative stabilization promoted healing and earlier mobilization, but carries a high-postoperative risk of infection. Nonoperative management should be considered in patients whose comorbidities prevent safe stabilization.

  18. Air Blasts from Cased and Uncased Explosives

    Energy Technology Data Exchange (ETDEWEB)

    Glenn, L. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-04-12

    The problem of a spherical blast in air is solved using the STUN code. For bare charges, the calculations are shown to be in excellent agreement with previous published results. It is demonstrated that, for an unconfined (uncased) chemical explosive, both range and time to effect scale inversely as the cube root of the yield and directly as the cube root of the ambient air density. It is shown that the peak overpressure decays to roughly 1/10 of ambient pressure in a scaled range of roughly 10 m/kg1/3 at sea level. At a height of 30 km, where the ambient density is a factor of 64 less, the range to the same decay increases to 40 m/kg1/3 . As a direct result of the scaling a single calculation suffices for all charge sizes and altitudes. Although the close-in results are sensitive to the nature of the explosive source and the equation of state of the air, this sensitivity is shown to virtually disappear at scaled ranges > 0.5 m/kg1/3 . For cased explosives the case thickness introduces an additional scale factor. Moreover, when the blast wave arrives at the inner case radius the case begins to expand. Fracture occurs when a critical value of the resulting hoop strain is reached, causing the case to shatter into fragments. A model is proposed to describe the size distribution of the fragments and their subsequent motion via drag interaction with the explosion products and ambient air. It is shown that a significant fraction of the charge energy is initially transmitted to the case fragments in the form of kinetic energy; for example, a 1 kg spherical charge with a 5 mm thick steel case has almost 29% of the total charge energy as initial kinetic energy of case fragments. This percentage increases with increasing case thickness and decreases with increasing charge size. The peak overpressure at a given range is 70-85% for cased explosives as compared with uncased and the peak impulse per unit area is 90-95%. The peak overpressure and

  19. Acceleration of tissue phase mapping by k-t BLAST: a detailed analysis of the influence of k-t-BLAST for the quantification of myocardial motion at 3T

    Directory of Open Access Journals (Sweden)

    Nienhaus G Ulrich

    2011-01-01

    Full Text Available Abstract Background The assessment of myocardial motion with tissue phase mapping (TPM provides high spatiotemporal resolution and quantitative motion information in three directions. Today, whole volume coverage of the heart by TPM encoding at high spatial and temporal resolution is limited by long data acquisition times. Therefore, a significant increase in imaging speed without deterioration of the quantitative motion information is required. For this purpose, the k-t BLAST acceleration technique was combined with TPM black-blood functional imaging of the heart. Different k-t factors were evaluated with respect to their impact on the quantitative assessment of cardiac motion. Results It is demonstrated that a k-t BLAST factor of two can be used with a marginal, but statistically significant deterioration of the quantitative motion data. Further increasing the k-t acceleration causes substantial alteration of the peak velocities and the motion pattern, but the temporal behavior of the contraction is well maintained up to an acceleration factor of six. Conclusions The application of k-t BLAST for the acceleration of TPM appears feasible. A reduction of the acquisition time of almost 45% could be achieved without substantial loss of quantitative motion information.

  20. Blast Mitigation by Water Mist, (3) Mitigation of Confined and Unconfined Blasts

    Science.gov (United States)

    2006-07-14

    Mitigation of blasts in chemical processing plants, including the fireworks and propellant industries, has also received considerable attention due to the...15.8982 02 => 15.9465 H20(l) + 21.1976 C02 + 10.3008 N2 + 2963.12 kcal 1 kg of HTA -3 contains: 0.29 kg (1.2768 gm-mol) TNT (C7H5N306) 0.22 kg (8.15419 gm...mol) Aluminum (Al) 0.49 kg (1.65429 gm-mol) HMX (C4H8N808) 1 kg HTA -3 => 9.80916 H20(l) + 4.46881 C(s) + 11.086 CO + 8.53235 N2 + 8.15419 Al(s

  1. Near-field investigation of the explosive dispersal of radioactive material based on a reconstructed spherical blast-wave flow.

    Science.gov (United States)

    Hummel, David; Ivan, Lucian

    2017-06-01

    A "dirty bomb" is a type of radiological dispersal device (RDD) that has been the subject of significant safety and security concerns given the disruption that would result from a postulated terrorist attack. Assessing the risks of radioactive dose in a hypothetical scenario requires models that can accurately predict dispersion in a realistic environment. Modelling a RDD is complicated by the fact that the most important phenomena occur over vastly disparate spatial and temporal length scales. Particulate dispersion in the air is generally considered on scales of hundreds to thousands of meters, and over periods of minutes and hours. Dispersion models are extremely sensitive, however, to the particle size and source characterization, which are determined in distances measured in micrometers to meters, over milliseconds or less. This study examines the extent to which the explosive blast determines the transport of contaminant particles relative to the atmospheric wind over distances relevant to "near-field" dispersion problems (i.e., hundreds of meters), which are relevant to urban environments. Our results indicate that whether or not the effect of the blast should be included in a near-field dispersion model is largely dependent on the size of the contaminant particle. Relatively large particles (i.e., >40 μm in diameter), which are most likely to be produced by a RDD, penetrate the leading shock front, thereby avoiding the reverse blast wind. Consequently, they travel much farther than suspended aerosols (<10 μm) before approaching the ambient wind velocity. This suggests that, for these "near-field" dispersion problems in urban environments, the transport of contaminants from the blast wave may be integral to accurately predicting their dispersion. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  2. Testing and modeling the dynamic response of foam materials for blast protection

    Science.gov (United States)

    Fitek, John H.

    The pressure wave released from an explosion can cause injury to the lungs. A personal armor system concept for blast lung injury protection consists of a polymer foam layer behind a rigid armor plate to be worn over the chest. This research develops a method for testing and modeling the dynamic response of foam materials to be used for down-selection of materials for this application. Constitutive equations for foam materials are incorporated into a lumped parameter model of the combined armor plate and foam system. Impact testing and shock tube testing are used to measure the foam model parameters and validate the model response to a pressure wave load. The plate and foam armor model is then coupled to a model of the human thorax. With a blast pressure wave input, the armor model is evaluated based on how it affects the injury-causing mechanism of chest wall motion. Results show that to reduce chest wall motion, the foam must compress at a relatively constant stress level, which requires a sufficient foam thickness.

  3. Multi-parameter measurements in a blast furnace using interactions of neutrons and γ-rays

    International Nuclear Information System (INIS)

    Shirakawa, Yoshiyuki; Horikoshi, Kiyomi

    1998-01-01

    This paper describes the possibility of multi-parameter measurements to meet the requirements for more precise and stable control of a blast furnace. A basic concept of such measurements is to make use of multi-radiations of neutrons and γ-rays, and to obtain multi-types of information on conditions of materials (iron ore and coke) inside the blast furnace. A prototype gauge was assembled and examined which consisted of a radiation source of 252 Cf, a neutron moderator, a lead shield, a bismuth germanate detector, a stainless casing and a control unit. Laboratory experiments showed that the gauge could measure the quantities to be essential to estimate material conditions. In practice, it clearly distinguished between iron ore and coke layers, and at the same time measured bulk density of iron contained in iron ore by counting thermal neutron capture γ-rays from iron. It also gave the information on material bulk density by detecting Compton scattered γ-rays from material, i.e. iron ore and coke. Finally, reducibility of iron ore was calculated by using both bulk densities. Relative accuracy of measurements was reasonable in practical use. The possibility of realization of the gauge has been proved and the on-line trial will be expected in the near future. (author)

  4. HLA-G expression on blasts and tolerogenic cells in patients affected by acute myeloid leukemia.

    Science.gov (United States)

    Locafaro, Grazia; Amodio, Giada; Tomasoni, Daniela; Tresoldi, Cristina; Ciceri, Fabio; Gregori, Silvia

    2014-01-01

    Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. The clinical relevance of HLA-G in several malignancies has been reported. However, the role of HLA-G expression and functions in Acute Myeloid Leukemia (AML) is still controversial. Our group identified a subset of tolerogenic dendritic cells, DC-10 that express HLA-G and secrete IL-10. DC-10 are present in the peripheral blood and are essential in promoting and maintaining tolerance via the induction of adaptive T regulatory (Treg) cells. We investigated HLA-G expression on blasts and the presence of HLA-G-expressing DC-10 and CD4(+) T cells in the peripheral blood of AML patients at diagnosis. Moreover, we explored the possible influence of the 3' untranslated region (3'UTR) of HLA-G, which has been associated with HLA-G expression, on AML susceptibility. Results showed that HLA-G-expressing DC-10 and CD4(+) T cells are highly represented in AML patients with HLA-G positive blasts. None of the HLA-G variation sites evaluated was associated with AML susceptibility. This is the first report describing HLA-G-expressing DC-10 and CD4(+) T cells in AML patients, suggesting that they may represent a strategy by which leukemic cells escape the host's immune system. Further studies on larger populations are required to verify our findings.

  5. HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia

    Directory of Open Access Journals (Sweden)

    Grazia Locafaro

    2014-01-01

    Full Text Available Human Leukocyte Antigen-G (HLA-G contributes to cancer cell immune escape from host antitumor responses. The clinical relevance of HLA-G in several malignancies has been reported. However, the role of HLA-G expression and functions in Acute Myeloid Leukemia (AML is still controversial. Our group identified a subset of tolerogenic dendritic cells, DC-10 that express HLA-G and secrete IL-10. DC-10 are present in the peripheral blood and are essential in promoting and maintaining tolerance via the induction of adaptive T regulatory (Treg cells. We investigated HLA-G expression on blasts and the presence of HLA-G-expressing DC-10 and CD4+ T cells in the peripheral blood of AML patients at diagnosis. Moreover, we explored the possible influence of the 3′ untranslated region (3′UTR of HLA-G, which has been associated with HLA-G expression, on AML susceptibility. Results showed that HLA-G-expressing DC-10 and CD4+ T cells are highly represented in AML patients with HLA-G positive blasts. None of the HLA-G variation sites evaluated was associated with AML susceptibility. This is the first report describing HLA-G-expressing DC-10 and CD4+ T cells in AML patients, suggesting that they may represent a strategy by which leukemic cells escape the host’s immune system. Further studies on larger populations are required to verify our findings.

  6. The Half Wave Plate Rotator for the BLAST-TNG Balloon-Borne Telescope

    Science.gov (United States)

    Setiawan, Hananiel; Ashton, Peter; Novak, Giles; Angilè, Francesco E.; Devlin, Mark J.; Galitzki, Nicholas; Ade, Peter; Doyle, Simon; Pascale, Enzo; Pisano, Giampaolo; Tucker, Carole E.

    2016-01-01

    The Next Generation Balloon-borne Large Aperture Submillimeter Telescope (BLAST-TNG) is an experiment designed to map magnetic fields in molecular clouds in order to study their role in the star formation process. The telescope will be launched aboard a high-altitude balloon in December 2016 for a 4-week flight from McMurdo station in Antarctica. BLAST-TNG will measure the polarization of submillimeter thermal emission from magnetically aligned interstellar dust grains, using large format arrays of kinetic inductance detectors operating in three bands centered at 250, 350, and 500 microns, with sub-arcminute angular resolution. The optical system includes an achromatic Half Wave Plate (HWP), mounted in a Half Wave Plate rotator (HWPr). The HWP and HWPr will operate at 4 K temperature to reduce thermal noise in our measurements, so it was crucial to account for the effects of thermal contraction at low temperature in the HWPr design. It was also equally important for the design to meet torque requirements while minimizing the power from friction and conduction dissipated at the 4 K stage. We also discuss our plan for cold testing the HWPr using a repurposed cryostat with a Silicon Diode thermometer read out by an EDAS-CE Ethernet data acquisition system.

  7. Use of blast-furnace slag in making durable concrete for waste management repositories

    International Nuclear Information System (INIS)

    Feldman, R.F.; Beaudoin, J.J.; Philipose, K.E.

    1991-02-01

    Waste repositories for the belowground disposal of low-level radioactive waste rely greatly on the durability of concrete for their required 500-year service life. A research program is in progress based on laboratory testing of concretes containing either Type 1 cement or cements containing 65 and 75 percent of blast-furnace slag, each at 4 water-cement ratios. It has been established that the degradation of the concrete will depend on the rate of ingress of corrosive agents - chlorides, sulphate ions and CO 2 . The ionic profiles and the kinetics of diffusion of these ions in the concretes have been measured by Secondary Electron Microscope (SEM) and Energy Dispersive X-ray Analysis (EDXA) techniques, and the results plotted according to a mathematical model. Predictions for service life of the concrete have been made from this model. These predictions have been correlated with properties of the concrete obtained from micro-structural, thermochemical and permeability measurements. The improvements in concrete durability due to blast-furnace slag additions are illustrated and discussed

  8. Micro Fluidic Channel Machining on Fused Silica Glass Using Powder Blasting.

    Science.gov (United States)

    Jang, Ho-Su; Cho, Myeong-Woo; Park, Dong-Sam

    2008-02-06

    In this study, micro fluid channels are machined on fused silica glass via powder blasting, a mechanical etching process, and the machining characteristics of the channels are experimentally evaluated. In the process, material removal is performed by the collision of micro abrasives injected by highly compressed air on to the target surface. This approach can be characterized as an integration of brittle mode machining based on micro crack propagation. Fused silica glass, a high purity synthetic amorphous silicon dioxide, is selected as a workpiece material. It has a very low thermal expansion coefficient and excellent optical qualities and exceptional transmittance over a wide spectral range, especially in the ultraviolet range. The powder blasting process parameters affecting the machined results are injection pressure, abrasive particle size and density, stand-off distance, number of nozzle scanning, and shape/size of the required patterns. In this study, the influence of the number of nozzle scanning, abrasive particle size, and pattern size on the formation of micro channels is investigated. Machined shapes and surface roughness are measured using a 3-dimensional vision profiler and the results are discussed.

  9. Micro Fluidic Channel Machining on Fused Silica Glass Using Powder Blasting

    Directory of Open Access Journals (Sweden)

    Dong-Sam Park

    2008-02-01

    Full Text Available In this study, micro fluid channels are machined on fused silica glass via powder blasting, a mechanical etching process, and the machining characteristics of the channels are experimentally evaluated. In the process, material removal is performed by the collision of micro abrasives injected by highly compressed air on to the target surface. This approach can be characterized as an integration of brittle mode machining based on micro crack propagation. Fused silica glass, a high purity synthetic amorphous silicon dioxide, is selected as a workpiece material. It has a very low thermal expansion coefficient and excellent optical qualities and exceptional transmittance over a wide spectral range, especially in the ultraviolet range. The powder blasting process parameters affecting the machined results are injection pressure, abrasive particle size and density, stand-off distance, number of nozzle scanning, and shape/size of the required patterns. In this study, the influence of the number of nozzle scanning, abrasive particle size, and pattern size on the formation of micro channels is investigated. Machined shapes and surface roughness are measured using a 3-dimensional vision profiler and the results are discussed.

  10. Pyramiding of blast and bacterial leaf blight resistance genes into ...

    African Journals Online (AJOL)

    Blast caused by the fungus Magnaporthe oryzae (Hebert) Barr. and bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) are two major diseases of rice (Oryza sativa). The use of varietal resistance is the most appropriate strategy for controlling the diseases, and molecular assisted selection can ...

  11. A numerical technique to design blast noise mitigation measures

    NARCIS (Netherlands)

    Berg, F. van den; Eerden, F.J.M. van der

    2007-01-01

    Large weapons, such as armor, artillery or demolitions, create a high-energy blast wave. It has a low frequency content, typically between 15 and 125 Hz, and can propagate over large distances. As a result it is a relative important cause for annoyance. Mitigation measures need to be close to the

  12. Effect of blasting on the strength of a rock mass

    Energy Technology Data Exchange (ETDEWEB)

    Muller, L.

    1964-01-01

    Although the fact that blasting concussions tend to loosen a rock mass has always been known, the enormous reduction in strength associated with such loosening is not generally recognized. Recent investigations of the effect of blasting on a rock mass have shown that even slight loosening may markedly reduce the strength. This factor introduces a new slant on modern blasting methods, some of which will have to be considered more critically. The sensitivity of the mass to impacts depends on stress concentrations at the end of joints (Kerbspannungen) and on tensile stresses developed in the immediate vicinity of a joint, even in regions where the field stresses are not tensile. Thus, the sensitivity depends on the shape and orientation of the joints and particularly on the degree of separation of the individual joint families. The orientation of the joint families to the strains produced by blasting is just as important as the reduction in overall strength arising from the drop in friction due to the effects of the ''knocking out'' process (Foppl) on the joint body complex. Concussions may critically increase the degree of separation of the joint network thus reducing the tensile and shear strengths of the rock mass. (19 refs.)

  13. Off-center blast in a shocked medium

    Science.gov (United States)

    Duncan-Miller, G. C.; Stone, W. D.

    2017-11-01

    When multiple blasts occur at different times, the situation arises in which a blast wave is propagating into a medium that has already been shocked. Determining the evolution in the shape of the second shock is not trivial, as it is propagating into air that is not only non-uniform, but also non-stationary. To accomplish this task, we employ the method of Kompaneets to determine the shape of a shock in a non-uniform media. We also draw from the work of Korycansky (Astrophys J 398:184-189. https://doi.org/10.1086/171847, 1992) on an off-center explosion in a medium with radially varying density. Extending this to treat non-stationary flow, and making use of approximations to the Sedov solution for the point blast problem, we are able to determine an analytic expression for the evolving shape of the second shock. In particular, we consider the case of a shock in air at standard ambient temperature and pressure, with the second shock occurring shortly after the original blast wave reaches it, as in a sympathetic detonation.

  14. Off-center blast in a shocked medium

    International Nuclear Information System (INIS)

    Duncan-Miller, G. C.; Stone, W. D.

    2017-01-01

    When multiple blasts occur at different times, the situation arises in which a blast wave is propagating into a medium that has already been shocked. Determining the evolution in the shape of the second shock is not trivial, as it is propagating into air that is not only non-uniform, but also non-stationary. To accomplish this task, we employ the method of Kompaneets to determine the shape of a shock in a non-uniform media. We also draw from the work of Korycansky (Astrophys J 398:184–189, 1992) on an off-center explosion in a medium with radially varying density. Extending this to treat non-stationary flow, and making use of approximations to the Sedov solution for the point blast problem, we are able to determine an analytic expression for the evolving shape of the second shock. In particular, we consider the case of a shock in air at standard ambient temperature and pressure, with the second shock occurring shortly after the original blast wave reaches it, as in a sympathetic detonation.

  15. Multiple blast-hole stresses and measured fragmentation

    Science.gov (United States)

    Dowding, Charles H.; Aimone, Catherine T.

    1985-01-01

    A wave superposition code was developed to calculate stresses explosivley induced by long, multiple blast holes within a three dimensional rock mass. Computed stresses were found to correlate with measured fragmentation from fourteen cases in coal cyclotherm geology when actual, rather than planned, initiation times were modelled.

  16. Studying and improving blast furnace cast iron quality

    Directory of Open Access Journals (Sweden)

    Т. К. Balgabekov

    2014-10-01

    Full Text Available In the article there are presented the results of studies to improve the quality of blast furnace cast iron. It was established that using fire clay suspension for increasing the mould covering heat conductivity improves significantly pig iron salable condition and filtration refining method decreases iron contamination by nonmetallic inclusions by 50 – 70 %.

  17. Blast wave injury prediction models for complex scenarios

    NARCIS (Netherlands)

    Teland, J.A.; Doormaal, J.C.A.M. van

    2012-01-01

    Blast waves from explosions can cause lethal injuries to humans. Development of injury criteria has been ongoing for many years, but with the main focus on free field conditions. However, with terrorist actions as a new threat, explosions in urban areas have become of much more interest. Urban areas

  18. Understanding yield reduction in rice due to leaf blast

    NARCIS (Netherlands)

    Bastiaans, L.

    1993-01-01

    The study described in this thesis focuses on a quantitative understanding of the effect of leaf blast on growth and production of a rice crop, based on insight in the physiological processes underlying damage. For this purpose, experimental research was conducted at two levels of

  19. A Mathematical Model for the Comparative Study of the Blast ...

    African Journals Online (AJOL)

    This paper presents a mathematical model of the study of the blast response of aluminium and steel panels. These panels are deemed sufficient to provided protective barrier against explosions, especially from terrorists. With the maximum deflection being the damage criteria used, the behaviour of both panel is studied.

  20. Injection of heavy fuel oil into the blast furnace

    Energy Technology Data Exchange (ETDEWEB)

    Paloposki, T. [Helsinki Univ. of Technology, Otaniemi (Finland); Hakala, J.; Mannila, P.; Laukkanen, J. [Oulu Univ. (Finland)

    1996-12-31

    This study deals with the injection and combustion of heavy fuel oil in blast furnaces. The injection of the oil was studied experimentally in a small-scale test rig. The combustion of the oil was analysed with a commercial computer program for flow and combustion simulations. Results from computer simulations show that the combustion of the oil can be improved by decreasing the size of the oil drops and by enhancing the mixing between the oil drops and the hot blast. The devolatilization rate of the oil mainly depends on the size of the oil drops. The combustion rate of the volatiles mainly depends on the effectiveness of turbulent mixing with combustion air. Methods to decrease the size of the oil drops were sought in the experimental part of the study. Experimental results show that the size of the oil drops increases with increasing mass flow rate of the oil and decreases with increasing velocity of the hot blast. Methods to improve the mixing between the oil drops and the hot blast are suggested but have not yet been experimentally tested. (author) (4 refs.)

  1. Recent development in blast performance of fiber-reinforced concrete

    Science.gov (United States)

    Hajek, R.; Foglar, M.; Kohoutkova, A.

    2017-09-01

    The paper presents an overview of the recent development in blast performance of fiber reinforced concrete. The paper builds on more than ten years’ history of the research in this field by the team of the Department of Concrete and Masonry Structures of the Faculty of Civil Engineering of the Czech Technical University in Prague.

  2. Assessment, development, and testing of glass for blast environments.

    Energy Technology Data Exchange (ETDEWEB)

    Glass, Sarah Jill

    2003-06-01

    Glass can have lethal effects including fatalities and injuries when it breaks and then flies through the air under blast loading (''the glass problem''). One goal of this program was to assess the glass problem and solutions being pursued to mitigate it. One solution to the problem is the development of new glass technology that allows the strength and fragmentation to be controlled or selected depending on the blast performance specifications. For example the glass could be weak and fail, or it could be strong and survive, but it must perform reliably. Also, once it fails it should produce fragments of a controlled size. Under certain circumstances it may be beneficial to have very small fragments, in others it may be beneficial to have large fragments that stay together. The second goal of this program was to evaluate the performance (strength, reliability, and fragmentation) of Engineered Stress Profile (ESP) glass under different loading conditions. These included pseudo-static strength and pressure tests and free-field blast tests. The ultimate goal was to provide engineers and architects with a glass whose behavior under blast loading is less lethal. A near-term benefit is a new approach for improving the reliability of glass and modifying its fracture behavior.

  3. Chloride ingress of carbonated blast furnace slag cement mortars

    NARCIS (Netherlands)

    Holthuizen, P.E.; Çopuroglu, O.; Polder, R.B.

    2017-01-01

    In the Netherlands civil engineering structures, such as overpasses, bridges and tunnels are generally built using blast furnace slag cement (BFSC, CEM III/B) concrete, because of its high resistance against chloride penetration. Although the Dutch experience regarding durability performance of BFSC

  4. Determination and expression of genes for resistance to blast ...

    African Journals Online (AJOL)

    Determination and expression of genes for resistance to blast (Magnaporthe oryza) in Basmati and non-Basmati indica rices (Oryza sativa L.) Naveen Kumar, D Singh, S Gupta, A Sirohi, B Ramesh, Preeti Sirohi, Parul Sirohi, Atar Singh, N Kumar, A Kumar, Rajendra Kumar, R Kumar, J Singh, P. Kumar, P. Chauhan, ...

  5. foreign body in scrotum following a boat engine blast accident

    African Journals Online (AJOL)

    David Ofori-Adjei

    1Urology Unit, 37 Military Hospital, P.O. Box KB 282, Korle-Bu, Accra, Ghana, 2Department of Surgery,. University of Ghana Medical School, PO Box 4236 ... evacuation limits complications. Keywords: Blast Injury, Scrotal ... emergency of the 37 Military Hospital for further care. Patient complained of a headache but had no ...

  6. Blasted copper slag as fine aggregate in Portland cement concrete.

    Science.gov (United States)

    Dos Anjos, M A G; Sales, A T C; Andrade, N

    2017-07-01

    The present work focuses on assessing the viability of applying blasted copper slag, produced during abrasive blasting, as fine aggregate for Portland cement concrete manufacturing, resulting in an alternative and safe disposal method. Leaching assays showed no toxicity for this material. Concrete mixtures were produced, with high aggregate replacement ratios, varying from 0% to 100%. Axial compressive strength, diametrical compressive strength, elastic modulus, physical indexes and durability were evaluated. Assays showed a significant improvement in workability, with the increase in substitution of fine aggregate. With 80% of replacement, the concrete presented lower levels of water absorption capacity. Axial compressive strength and diametrical compressive strength decreased, with the increase of residue replacement content. The greatest reductions of compressive strength were found when the replacement was over 40%. For tensile strength by diametrical compression, the greatest reduction occurred for the concrete with 80% of replacement. After the accelerated aging, results of mechanic properties showed a small reduction of the concrete with blasted copper slag performance, when compared with the reference mixture. Results indicated that the blasted copper slag is a technically viable material for application as fine aggregate for concrete mixtures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Gene interactions and genetics of blast resistance and yield ...

    Indian Academy of Sciences (India)

    2016-08-26

    Oryza sativa L.) ... four blast resistance genes Pi1, Pi2, Pi33 and Pi54 in combination were used to study the nature and magnitude of gene action for disease resistance and yield attributes. ... Please take note of this change.

  8. Development of a Strategy for Simulating Blast-Vehicle Interactions

    Science.gov (United States)

    2010-09-01

    TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER OF PAGES 140 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified...soil model for simulating stress wave propagation due to blast loading. International Journal fro Numerical and Analytical Methods in Geomechanics , 28

  9. Measurements of near-field blast effects using kinetic plates

    Science.gov (United States)

    Manner, V. W.; Pemberton, S. J.; Brown, G. W.; Tappan, B. C.; Hill, L. G.; Preston, D. N.; Neuscamman, S. J.; Glascoe, L. G.

    2014-05-01

    Few tests have been designed to measure the near-field blast impulse of ideal and non-ideal explosives, mostly because of the inherent experimental difficulties due to non-transparent fireballs and thermal effects on gauges. In order to measure blast impulse in the near-field, a new test has been developed by firing spherical charges at 152 mm (6 in) from steel plates and probing acceleration using laser velocimetry. Tests measure the velocity imparted to the steel plate in the 50 - 300 μs timeframe, and are compared with free-field overpressure measurements at 1.52 m (5 ft) and ms timescales using piezoelectric pencil gauges. Specifically, tests have been performed with C4 to probe the contributions of ideal explosives and charge size effects. Non-ideal aluminized explosive formulations have been studied to explore the role of aluminum in near-field blast effects and far-field pressure, and are compared with formulations using LiF as an inert surrogate replacement for Al. The results are compared with other near-field blast tests and cylinder tests, and the validity of this test is explored with modeling and basic theory.

  10. A research on ceramsite obtained from blast furnace slag and ...

    African Journals Online (AJOL)

    In order to solve disposal problem of solid waste, blast furnace slag (BFS) and sewage sludge (SS) were tested as components for producing ceramsite. This study investigated the feasibility of that at different preheating and sintering temperature and duration and different mass ratios (BFS: SS: clay). The results show that ...

  11. Foreign body in scrotum following a boat engine blast accident ...

    African Journals Online (AJOL)

    Male genital injuries, demand prompt management to prevent long-term sexual and psychological damage. Injuries to the scrotum and contents may produce impaired fertility.We report our experience in diagnosing and managing a case of a foreign body in the scrotum following a boat engine blast accident. This case ...

  12. Development of Experimental Tissue Models for Blast Injury

    Science.gov (United States)

    Butler, Benjamin; Bo, Chiara; Williams, Alun; Jardine, Andy; Brown, Katherine

    2013-06-01

    There is a pressing need to better understand the relationship between the intensity of a blast wave and the clinical consequences for victims of an explosion. In order to quantitatively study how these factors correlate with one another, blast injury tissue models are being developed. Sections of larynx, trachea and pulmonary tissue were excised from a recently sacrificed pig and maintained on ice prior to testing. The samples were subjected to strain rates of between 0.001 s-1 and 1000 s-1 in the laboratory by using a Split Hopkinson Pressure Bar and quasi-static testing apparatus. During high strain rate testing, samples were housed in a polycarbonate chamber which permitted experimentation on tissue held in fluid. Data were analysed using 1, 2 and 3 wave analysis software in Matlab to yield information about the material properties of both undamaged and damaged tissues. In addition, macroscopic changes in tissue organization were also visualized using histopathological techniques. This work is being extended to cellular and animal models to derive more detailed information about the underlying molecular changes relating to blast-induced damage and repair. The Royal British Legion Centre for Blast Injury Studies.

  13. Numerical simulation of armored vehicles subjected to undercarriage landmine blasts

    Science.gov (United States)

    Erdik, A.; Kilic, S. A.; Kilic, N.; Bedir, S.

    2016-07-01

    Landmine threats play a crucial role in the design of armored personnel carriers. Therefore, a reliable blast simulation methodology is valuable to the vehicle design development process. The first part of this study presents a parametric approach for the quantification of the important factors such as the incident overpressure, the reflected overpressure, the incident impulse, and the reflected impulse for the blast simulations that employ the Arbitrary Lagrangian-Eulerian formulation. The effects of mesh resolution, mesh topology, and fluid-structure interaction (FSI) parameters are discussed. The simulation results are compared with the calculations of the more established CONventional WEaPons (CONWEP) approach based on the available experimental data. The initial findings show that the spherical topology provides advantages over the Cartesian mesh domains. Furthermore, the FSI parameters play an important role when coarse Lagrangian finite elements are coupled with fine Eulerian elements at the interface. The optimum mesh topology and the mesh resolution of the parametric study are then used in the landmine blast simulation. The second part of the study presents the experimental blast response of an armored vehicle subjected to a landmine explosion under the front left wheel in accordance with the NATO AEP-55 Standard. The results of the simulations show good agreement with the experimental measurements.

  14. Columbia River Channel Improvement Project Rock Removal Blasting: Monitoring Plan

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Thomas J.; Johnson, Gary E.

    2010-01-29

    This document provides a monitoring plan to evaluate take as outlined in the National Marine Fisheries Service 2002 Biological Opinion for underwater blasting to remove rock from the navigation channel for the Columbia River Channel Improvement Project. The plan was prepared by the Pacific Northwest National Laboratory (PNNL) for the U.S. Army Corps of Engineers (USACE), Portland District.

  15. Finite Element Analysis for CFST Columns under Blast Loading

    Directory of Open Access Journals (Sweden)

    Peyman Beiranvand

    2017-10-01

    Full Text Available The columns of frame structures are the key load-bearing components and the exterior columns are susceptible to attack in terrorist blasts. When subjected to blast loads, the columns would suffer a loss of bearing capacity to a certain extent due to the damage imparted which may lead to their collapse and even cause the progressive collapse of the whole structure . The concrete-filled steel columns have been extensively used in the world due to the existence of all suitable characteristics of concrete and steel, more ductility, increasing concrete confinement using the steel wall, the large energy-absorption capacity and the appropriate fire behavior. In the present study, the concrete-filled steel square columns have been simulated under the influence of the blast load using the ABAQUS software. These responses have been compared for scaled distances based on the distance to the source and the weight of the explosive material. As a result, it can be seen that although concrete deformation has been restricted using the steel tube, the inner layer of concrete has been seriously damaged and the column displacement has been decreased by increasing the scaled distance. We also concluded that the concrete-filled steel columns have the high ductility and the blast resistance.

  16. Explosively-Driven Blast Waves in Small-Diameter Tubes

    Science.gov (United States)

    Cooper, M. A.; Marinis, R. T.; Oliver, M. S.

    Studies on blast waves are motivated by the need to understand dynamic pressure loadings in accident scenarios associated with rapid energy release in confined geometries. Explosions from fuel-air mixtures, explosives and industrial accidents often occur within a range of length scales associated with ducts, pipes, corridors, and tunnels [1, 2].

  17. Granulated blast furnace slag – A boon for foundry industry

    African Journals Online (AJOL)

    In the present investigation efforts have been put together to employ Granulated Blast furnace (GBF) slag as mould material for replacement of existing silica sand either full or partial in foundry industry. Nishiyama procedure was assumed for appraising the same. The process factors reflected on for this were the % of ...

  18. On dimensionless loading parameters for close-in blasts

    Directory of Open Access Journals (Sweden)

    K Micallef

    2016-10-01

    Full Text Available Close-range blasts pose a threat through severe damage to structures and injury or death. In this work, the spatial and temporal descriptions of a localised blast load are presented using 6 non-dimensional parameters. These are found to be solely functions of the charge stand-off distance to diameter ratio for a cylindrically-shaped charge. Numerical simulations of a localised blast are performed using AUTODYN, where the pressure variation on a rigid barrier for various charge stand-off/diameter combinations is obtained. The least-square regression is then utilised to obtain the relationship between stand-off/diameter ratio and dimensionless loading parameters. The relevant expressions and dimensionless charts are presented. The proposed equations are verified by comparing experimental data with numerical results obtained by finite element analysis (FEA of blast loaded steel plates (using the user-defined subroutine VDLOAD implemented in the FEA package ABAQUS/Explicit. Excellent correlation of the measured permanent displacement with numerically predicted results is obtained.

  19. DNA marker characterization for allele mining of blast and bacterial ...

    African Journals Online (AJOL)

    admiistrator

    2013-05-01

    May 1, 2013 ... Marker assisted selection of bacterial blight resistance genes in rice. Biochem Genet. 39 (7): 261-278. Du PV, Loan, LC, Sang ND (2007). Blast research in Mekong river delta of Vietnam. In: JIRCAS (Japan International Research Center for Agricultural Sciences, Tsukuba, Japan) working report No. 53,.

  20. Test methods for protective footwear against AP mine blast

    NARCIS (Netherlands)

    Cronin, D.S.; Williams, K.; Bass, C.R.; Magnan, P.; Dosquet, F.; Bergeron, D.M.; Bree, J.L.M.J. van

    2003-01-01

    The testing and development of protective footwear for anti-personnel landmine blast threats is of great importance to civilian and military deminers, and peacekeepers. This study will review the wide range of test methods that have been developed by NATO countries to test footwear against the

  1. Acceleration-based methodology to assess the blast mitigation performance of explosive ordnance disposal helmets

    Science.gov (United States)

    Dionne, J. P.; Levine, J.; Makris, A.

    2018-01-01

    To design the next generation of blast mitigation helmets that offer increasing levels of protection against explosive devices, manufacturers must be able to rely on appropriate test methodologies and human surrogates that will differentiate the performance level of various helmet solutions and ensure user safety. Ideally, such test methodologies and associated injury thresholds should be based on widely accepted injury criteria relevant within the context of blast. Unfortunately, even though significant research has taken place over the last decade in the area of blast neurotrauma, there currently exists no agreement in terms of injury mechanisms for blast-induced traumatic brain injury. In absence of such widely accepted test methods and injury criteria, the current study presents a specific blast test methodology focusing on explosive ordnance disposal protective equipment, involving the readily available Hybrid III mannequin, initially developed for the automotive industry. The unlikely applicability of the associated brain injury criteria (based on both linear and rotational head acceleration) is discussed in the context of blast. Test results encompassing a large number of blast configurations and personal protective equipment are presented, emphasizing the possibility to develop useful correlations between blast parameters, such as the scaled distance, and mannequin engineering measurements (head acceleration). Suggestions are put forward for a practical standardized blast testing methodology taking into account limitations in the applicability of acceleration-based injury criteria as well as the inherent variability in blast testing results.

  2. Monte Carlo simulation as a tool to predict blasting fragmentation based on the Kuz Ram model

    Science.gov (United States)

    Morin, Mario A.; Ficarazzo, Francesco

    2006-04-01

    Rock fragmentation is considered the most important aspect of production blasting because of its direct effects on the costs of drilling and blasting and on the economics of the subsequent operations of loading, hauling and crushing. Over the past three decades, significant progress has been made in the development of new technologies for blasting applications. These technologies include increasingly sophisticated computer models for blast design and blast performance prediction. Rock fragmentation depends on many variables such as rock mass properties, site geology, in situ fracturing and blasting parameters and as such has no complete theoretical solution for its prediction. However, empirical models for the estimation of size distribution of rock fragments have been developed. In this study, a blast fragmentation Monte Carlo-based simulator, based on the Kuz-Ram fragmentation model, has been developed to predict the entire fragmentation size distribution, taking into account intact and joints rock properties, the type and properties of explosives and the drilling pattern. Results produced by this simulator were quite favorable when compared with real fragmentation data obtained from a blast quarry. It is anticipated that the use of Monte Carlo simulation will increase our understanding of the effects of rock mass and explosive properties on the rock fragmentation by blasting, as well as increase our confidence in these empirical models. This understanding will translate into improvements in blasting operations, its corresponding costs and the overall economics of open pit mines and rock quarries.

  3. Reconstruction of improvised explosive device blast loading to personnel in the open

    Science.gov (United States)

    Wiri, Suthee; Needham, Charles

    2016-05-01

    Significant advances in reconstructing attacks by improvised explosive devices (IEDs) and other blast events are reported. A high-fidelity three-dimensional computational fluid dynamics tool, called Second-order Hydrodynamic Automatic Mesh Refinement Code, was used for the analysis. Computer-aided design models for subjects or vehicles in the scene accurately represent geometries of objects in the blast field. A wide range of scenario types and blast exposure levels were reconstructed including free field blast, enclosed space of vehicle cabin, IED attack on a vehicle, buried charges, recoilless rifle operation, rocket-propelled grenade attack and missile attack with single subject or multiple subject exposure to pressure levels from ˜ 27.6 kPa (˜ 4 psi) to greater than 690 kPa (>100 psi). To create a full 3D pressure time-resolved reconstruction of a blast event for injury and blast exposure analysis, a combination of intelligence data and Blast Gauge data can be used to reconstruct an actual in-theatre blast event. The methodology to reconstruct an event and the "lessons learned" from multiple reconstructions in open space are presented. The analysis uses records of blast pressure at discrete points, and the output is a spatial and temporal blast load distribution for all personnel involved.

  4. BlastR—fast and accurate database searches for non-coding RNAs

    Science.gov (United States)

    Bussotti, Giovanni; Raineri, Emanuele; Erb, Ionas; Zytnicki, Matthias; Wilm, Andreas; Beaudoing, Emmanuel; Bucher, Philipp; Notredame, Cedric

    2011-01-01

    We present and validate BlastR, a method for efficiently and accurately searching non-coding RNAs. Our approach relies on the comparison of di-nucleotides using BlosumR, a new log-odd substitution matrix. In order to use BlosumR for comparison, we recoded RNA sequences into protein-like sequences. We then showed that BlosumR can be used along with the BlastP algorithm in order to search non-coding RNA sequences. Using Rfam as a gold standard, we benchmarked this approach and show BlastR to be more sensitive than BlastN. We also show that BlastR is both faster and more sensitive than BlastP used with a single nucleotide log-odd substitution matrix. BlastR, when used in combination with WU-BlastP, is about 5% more accurate than WU-BlastN and about 50 times slower. The approach shown here is equally effective when combined with the NCBI-Blast package. The software is an open source freeware available from www.tcoffee.org/blastr.html. PMID:21624887

  5. Study of the action of blast deck charge in rocky soils

    Directory of Open Access Journals (Sweden)

    Boiko V.V.

    2017-04-01

    Full Text Available Blasting (B in the industry, including the mining extraction of minerals, are carried out mostly with the use of blasthole charges that systematically distributed on the block that is undermined, by individual groups. The latter are blasted according to the scheme of short-delay firing (SDF through the intervals that are accepted not less than 20 Ms. Thus, the seismic effect of group charge explosion, consisting of individual blasthole charges and that actually is a group located charge determined by the formula of concentrated charge. Blast deck charges are effectively used in the driving of the trenches in the mining, formation of screens and cracks near the security objects. Only this method of performing blasting allows to define seismic effect in the transition from one diameter of a charge to another, as well as to determine the actual number of detonated charges in one group, which may differ from the calculated in drilling and blasting project. The work analyzes the physical essence of processes happened while blasting of blast deck charges. The effect of the orientation of the seismic action of blasting of blast deck charges towards the allocation line of charges is investigated. The results of generalized dependence of the speed of the displacement of the ground by the blast parameters and epicentral distance are obtained. We demonstrate with specific examples that blast deck charges that blasting simultaneously make a major chain of the career massive explosions at mining. Keywords: seismic fluctuations; the number of charges; the interaction of charges; the distance between the charges; the coefficients of the seismicity and the attenuation of the intensity of the waves; the unit charge; blast deck and blasthole charges; phase shifting; effective charge.

  6. A multiscale approach to blast neurotrauma modeling:Part II: Methodology for inducing blast injury to in vitro models

    Directory of Open Access Journals (Sweden)

    Gwen B. Effgen

    2012-02-01

    Full Text Available Due to the prominent role of improvised explosive devices (IEDs in wounding patterns of U.S. war-fighters in Iraq and Afghanistan, blast injury has risen to a new level of importance and is recognized to be a major cause of injuries to the brain. However, an injury risk-function for microscopic, macroscopic, behavioral, and neurological deficits has yet to be defined. While operational blast injuries can be very complex and thus difficult to analyze, a simplified blast injury model would facilitate studies correlating biological outcomes with blast biomechanics to define tolerance criteria. Blast-induced traumatic brain injury (bTBI results from the translation of a shock wave in air, such as that produced by an IED, into a pressure wave within the skull-brain complex. Our blast injury methodology recapitulates this phenomenon in vitro, allowing for control of the injury biomechanics via a compressed-gas shock tube used in conjunction with a custom-designed, fluid-filled receiver that contains the living culture. The receiver converts the air shock wave into a fast-rising pressure transient with minimal reflections, mimicking the intracranial pressure history in blast. We have developed an organotypic hippocampal slice culture model that exhibits cell death when exposed to a 530  17.7 kPa peak overpressure with a 1.026 ± 0.017 ms duration and 190 ± 10.7 kPa-ms impulse in-air. We have also injured a simplified in vitro model of the blood-brain barrier, which exhibits disrupted integrity immediately following exposure to 581  10.0 kPa peak overpressure with a 1.067 ms ± 0.006 ms duration and 222 ± 6.9 kPa-ms impulse in-air. To better prevent and treat bTBI, both the initiating biomechanics and the ensuing pathobiology must be understood in greater detail. A well-characterized, in vitro model of bTBI, in conjunction with animal models, will be a powerful tool for developing strategies to mitigate the risks of bTBI.

  7. Characterization of Microbial Communities in Subsurface Nuclear Blast Cavities of the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Moser, Duane; Russell, Chuck; Marshall, Matthew; Czerwinski, Ken; Daly, Michael J; Zavarin, Mavrik

    2008-02-08

    This exploratory research project is designed to test fundamental hypotheses concerning the possible existence and nature of indigenous microbial populations in Nevada Test Site (NTS) subsurface nuclear blast cavities. Although subsurface microbiological studies have been performed at the NTS in the past, radioactive zones have yet to be addressed. Nuclear blast zone microbiology is a completely new field and our team is well-positioned to collect and analyze samples that have never before been available to microbiologists. Relevant samples are now being obtained by incorporating microbiological collections into an ongoing annual hot well sampling program being conducted by other agencies. A combination of cultivation-based and molecular microbial detection protocols is being utilized at multiple locations to survey for uncultivable microorganisms and to develop a culture collection which will be characterized for radionuclide- and metal-reduction capabilities. Given that redox manipulations mediated by microorganisms can impact the mobility of DOE contaminants, a positive outcome from this work would have significant implications for management strategies at this and other DOE sites. A primary objective of the project has been the establishment of the regulatory and technical framework necessary to enable our acquisition of samples. Thus, much of our activity in the first phase of this work has involved the development an approved Field Area Work Plan (FAWP), Radiological Work Permit (RWP), and other documentation required for radiological work at the NTS. We have also invested significant time into ensuring that all personnel possess the required training (e.g. Radworker II and 40 hr. HAZWOPER) for access to the hot well sampling sites. Laboratory facilities, required for field processing of radioactive samples as well as DNA extraction and other manipulations, have been secured both the NTS (Mercury, NV) and UNLV. Although our year-1 field work was delayed due

  8. Study of high Mach number laser driven blast waves in gases

    International Nuclear Information System (INIS)

    Edens, A. D.; Adams, R. G.; Rambo, P.; Ruggles, L.; Smith, I. C.; Porter, J. L.; Ditmire, T.

    2010-01-01

    A series of experiments were performed examining the evolution of blast waves produced by laser irradiation of a target immersed in gas. Blast waves were produced by illumination of wires by 1 kJ, 1 ns laser pulses from the Z-Beamlet laser at Sandia National Laboratories. The blast waves were imaged by probe laser pulses at various times to examine the trajectory, radiative precursor, and induced perturbations on the blast wave front. Well defined perturbations were induced on the blast wave front with arrays of wires placed in the gas and the results of the experiments are compared to the theoretical predictions for the Vishniac overstability. It is found that the experimental results are in general agreement with these theoretical predictions on thin blast wave shells and are in quantitative agreement in the simplest case.

  9. Structural Response to Blast Loading: The Effects of Corrosion on Reinforced Concrete Structures

    Directory of Open Access Journals (Sweden)

    Hakan Yalciner

    2014-01-01

    Full Text Available Structural blast design has become a necessary part of the design with increasing terrorist attacks. Terrorist attacks are not the one to make the structures important against blast loading where other explosions such as high gas explosions also take an important place in structural safety. The main objective of this study was to verify the structural performance levels under the impact of different blast loading scenarios. The blast loads were represented by using triangular pulse for single degree of freedom system. The effect of blast load on both corroded and uncorroded reinforced concrete buildings was examined for different explosion distances. Modified plastic hinge properties were used to ensure the effects of corrosion. The results indicated that explosion distance and concrete strength were key parameters to define the performance of the structures against blast loading.

  10. Blast-Resistant Improvement of Sandwich Armor Structure with Aluminum Foam Composite

    Directory of Open Access Journals (Sweden)

    Shu Yang

    2013-01-01

    Full Text Available Sandwich armor structures with aluminum foam can be utilized to protect a military vehicle from harmful blast load such as a landmine explosion. In this paper, a system-level dynamic finite element model is developed to simulate the blast event and to evaluate the blast-resistant performance of the sandwich armor structure. It is found that a sandwich armor structure with only aluminum foam is capable of mitigating crew injuries under a moderate blast load. However, a severe blast load causes force enhancement and results in much worse crew injury. An isolating layer between the aluminum foam and the vehicle floor is introduced to remediate this drawback. The results show that the blast-resistant capability of the innovative sandwich armor structure with the isolating layer increases remarkably.

  11. Minimization of Blast furnace Fuel Rate by Optimizing Burden and Gas Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Chenn Zhou

    2012-08-15

    The goal of the research is to improve the competitive edge of steel mills by using the advanced CFD technology to optimize the gas and burden distributions inside a blast furnace for achieving the best gas utilization. A state-of-the-art 3-D CFD model has been developed for simulating the gas distribution inside a blast furnace at given burden conditions, burden distribution and blast parameters. The comprehensive 3-D CFD model has been validated by plant measurement data from an actual blast furnace. Validation of the sub-models is also achieved. The user friendly software package named Blast Furnace Shaft Simulator (BFSS) has been developed to simulate the blast furnace shaft process. The research has significant benefits to the steel industry with high productivity, low energy consumption, and improved environment.

  12. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing.

    Science.gov (United States)

    VandeVord, Pamela J; Leonardi, Alessandra Dal Cengio; Ritzel, David

    2016-01-01

    Recent military combat has heightened awareness to the complexity of blast-related traumatic brain injuries (bTBI). Experiments using animal, cadaver, or biofidelic physical models remain the primary measures to investigate injury biomechanics as well as validate computational simulations, medical diagnostics and therapies, or protection technologies. However, blast injury research has seen a range of irregular and inconsistent experimental methods for simulating blast insults generating results which may be misleading, cannot be cross-correlated between laboratories, or referenced to any standard for exposure. Both the US Army Medical Research and Materiel Command and the National Institutes of Health have noted that there is a lack of standardized preclinical models of TBI. It is recommended that the blast injury research community converge on a consistent set of experimental procedures and reporting of blast test conditions. This chapter describes the blast conditions which can be recreated within a laboratory setting and methodology for testing in vivo models within the appropriate environment.

  13. Optimization long hole blast fragmentation techniques and detonating circuit underground uranium mine stope

    International Nuclear Information System (INIS)

    Li Qin; Yang Lizhi; Song Lixia; Qin De'en; Xue Yongshe; Wang Zhipeng

    2012-01-01

    Aim at high rate of large blast fragmentation, a big difficulty in long hole drilling and blasting underground uranium mine stope, it is pointed out at the same time of taking integrated technical management measures, the key is to optimize the drilling and blasting parameters and insure safety the act of one that primes, adopt 'minimum burden' blasting technique, renew the stope fragmentation process, and use new process of hole bottom indirect initiation fragmentation; optimize the detonating circuit and use safe, reliable and economically rational duplex non-electric detonating circuit. The production practice shows that under the guarantee of strictly controlled construction quality, the application of optimized blast fragmentation technique has enhanced the reliability of safety detonation and preferably solved the problem of high rate of large blast fragments. (authors)

  14. WImpiBLAST: web interface for mpiBLAST to help biologists perform large-scale annotation using high performance computing.

    Directory of Open Access Journals (Sweden)

    Parichit Sharma

    Full Text Available The function of a newly sequenced gene can be discovered by determining its sequence homology with known proteins. BLAST is the most extensively used sequence analysis program for sequence similarity search in large databases of sequences. With the advent of next generation sequencing technologies it has now become possible to study genes and their expression at a genome-wide scale through RNA-seq and metagenome sequencing experiments. Functional annotation of all the genes is done by sequence similarity search against multiple protein databases. This annotation task is computationally very intensive and can take days to obtain complete results. The program mpiBLAST, an open-source parallelization of BLAST that achieves superlinear speedup, can be used to accelerate large-scale annotation by using supercomputers and high performance computing (HPC clusters. Although many parallel bioinformatics applications using the Message Passing Interface (MPI are available in the public domain, researchers are reluctant to use them due to lack of expertise in the Linux command line and relevant programming experience. With these limitations, it becomes difficult for biologists to use mpiBLAST for accelerating annotation. No web interface is available in the open-source domain for mpiBLAST. We have developed WImpiBLAST, a user-friendly open-source web interface for parallel BLAST searches. It is implemented in Struts 1.3 using a Java backbone and runs atop the open-source Apache Tomcat Server. WImpiBLAST supports script creation and job submission features and also provides a robust job management interface for system administrators. It combines script creation and modification features with job monitoring and management through the Torque resource manager on a Linux-based HPC cluster. Use case information highlights the acceleration of annotation analysis achieved by using WImpiBLAST. Here, we describe the WImpiBLAST web interface features and architecture

  15. WImpiBLAST: web interface for mpiBLAST to help biologists perform large-scale annotation using high performance computing.

    Science.gov (United States)

    Sharma, Parichit; Mantri, Shrikant S

    2014-01-01

    The function of a newly sequenced gene can be discovered by determining its sequence homology with known proteins. BLAST is the most extensively used sequence analysis program for sequence similarity search in large databases of sequences. With the advent of next generation sequencing technologies it has now become possible to study genes and their expression at a genome-wide scale through RNA-seq and metagenome sequencing experiments. Functional annotation of all the genes is done by sequence similarity search against multiple protein databases. This annotation task is computationally very intensive and can take days to obtain complete results. The program mpiBLAST, an open-source parallelization of BLAST that achieves superlinear speedup, can be used to accelerate large-scale annotation by using supercomputers and high performance computing (HPC) clusters. Although many parallel bioinformatics applications using the Message Passing Interface (MPI) are available in the public domain, researchers are reluctant to use them due to lack of expertise in the Linux command line and relevant programming experience. With these limitations, it becomes difficult for biologists to use mpiBLAST for accelerating annotation. No web interface is available in the open-source domain for mpiBLAST. We have developed WImpiBLAST, a user-friendly open-source web interface for parallel BLAST searches. It is implemented in Struts 1.3 using a Java backbone and runs atop the open-source Apache Tomcat Server. WImpiBLAST supports script creation and job submission features and also provides a robust job management interface for system administrators. It combines script creation and modification features with job monitoring and management through the Torque resource manager on a Linux-based HPC cluster. Use case information highlights the acceleration of annotation analysis achieved by using WImpiBLAST. Here, we describe the WImpiBLAST web interface features and architecture, explain design

  16. A Comparative Study of Ground and Underground Vibrations Induced by Bench Blasting

    OpenAIRE

    Xiuzhi Shi; Xianyang Qiu; Jian Zhou; Dan Huang; Xin Chen; Yonggang Gou

    2016-01-01

    Ground vibrations originating from bench blasting may cause damage to slopes, structures, and underground workings in close proximity to an operating open-pit mine. It is important to monitor and predict ground vibration levels induced by blasting and to take measures to reduce their hazardous effects. The aims of this paper are to determine the weaker protection objects by comparatively studying bench blasting induced vibrations obtained at surface and in an underground tunnel in an open-pit...

  17. Blasting Impact by the Construction of an Underground Research Tunnel in KAERI

    International Nuclear Information System (INIS)

    Kwon, S.; Cho, W. J.

    2005-12-01

    The underground research tunnel, which is under construction in KAERI for the validation of HLW disposal system, is excavated by drill and blasting method using high-explosives. In order not to disturb the operation at the research facilities such as HANARO reactor, it is critical to develop a blasting design , which will not influence on the facilities, even though several tens of explosives are detonated almost simultaneously. To develop a reasonable blasting design, a test blasting at the site should be performed. A preliminary analysis for predicting the expected vibration and noise by the blasting for the construction of the underground research tunnel was performed using a typical empirical equation. From the study, a blasting design could be developed not to influence on the major research facilities in KAERI. For the validation of the blasting design, a test blasting was carried out at the site and the parameters of vibration equation could be determined using the measured data during the test blasting. Using the equation, it was possible to predict the vibration at different locations at KAERI and to conclude that the blasting design would meet the design criteria at the major facilities in KAERI. The study would verify the applicability of blasting method for the construction of a research tunnel in a rock mass and that would help the design and construction of large scale underground research laboratory, which might be carried out in the future. It is also meaningful to accumulate technical experience for enhancing the reliability and effectiveness of the design and construction of the HLW disposal repository, which will be constructed in deep underground by drill and blasting technique

  18. Carbonation Characteristics of Alkali-Activated Blast-Furnace Slag Mortar

    Directory of Open Access Journals (Sweden)

    Keum-Il Song

    2014-01-01

    Full Text Available Alkali-activated ground granulated blast-slag (AAS is the most obvious alternative material for ordinary Portland cement (OPC. However, to use it as a structural material requires the assessment and verification of its durability. The most important factor for a durability evaluation is the degree of carbonation resistance, and AAS is known to show lower performance than OPC. A series of experiments was conducted with a view to investigate the carbonation characteristics of AAS binder. As a consequence, it was found that the major hydration product of AAS was calcium silicate hydrate (CSH, with almost no portlandite, unlike the products of OPC. After carbonation, the CSH of AAS turned into amorphous silica gel which was most likely why the compressive strength of AAS became weaker after carbonation. An increase of the activator dosage leads AAS to react more quickly and produce more CSH, increasing the compaction, compressive strength, and carbonation resistance of the microstructure.

  19. SITUATIONAL CONTROL OF HOT BLAST STOVES GROUP BASED ON DECISION TREE

    Directory of Open Access Journals (Sweden)

    E. I. Kobysh

    2016-09-01

    Full Text Available In this paper was developed the control system of group of hot blast stoves, which operates on the basis of the packing heating control subsystem and subsystem of forecasting of modes duration in the hot blast stoves APCS of iron smelting in a blast furnace. With the use of multi-criteria optimization methods, implemented the adjustment of control system conduct, which takes into account the current production situation that has arisen in the course of the heating packing of each hot blast stove group. Developed a situation recognition algorithm and the choice of scenarios of control based on a decision tree.

  20. The effect of blast furnace coke quality on the possibility of its use

    Directory of Open Access Journals (Sweden)

    A. Konstanciak

    2013-04-01

    Full Text Available In the paper behavior of the blast-furnace coke in the high temperature was presented. Comparative analysis of the chemical composition of the blast-furnace coke and the heat treatment of it were done. Coefficients M10 and M40 with the thermo-abrasiveness for chosen cokes were compared. The influence of ash content of the coke on the blast-furnace bed permeability was defined. Usefulness of the coke to blast-furnace process was also defined.

  1. Blast overpressure induced axonal injury changes in rat brainstem and spinal cord

    Directory of Open Access Journals (Sweden)

    Srinivasu Kallakuri

    2015-01-01

    Full Text Available Introduction: Blast induced neurotrauma has been the signature wound in returning soldiers from the ongoing wars in Iraq and Afghanistan. Of importance is understanding the pathomechansim(s of blast overpressure (OP induced axonal injury. Although several recent animal models of blast injury indicate the neuronal and axonal injury in various brain regions, animal studies related to axonal injury in the white matter (WM tracts of cervical spinal cord are limited. Objective: The purpose of this study was to assess the extent of axonal injury in WM tracts of cervical spinal cord in male Sprague Dawley rats subjected to a single insult of blast OP. Materials and Methods: Sagittal brainstem sections and horizontal cervical spinal cord sections from blast and sham animals were stained by neurofilament light (NF-L chain and beta amyloid precursor protein immunocytochemistry and observed for axonal injury changes. Results: Observations from this preliminary study demonstrate axonal injury changes in the form of prominent swellings, retraction bulbs, and putative signs of membrane disruptions in the brainstem and cervical spinal cord WM tracts of rats subjected to blast OP. Conclusions: Prominent axonal injury changes following the blast OP exposure in brainstem and cervical spinal WM tracts underscores the need for careful evaluation of blast induced injury changes and associated symptoms. NF-L immunocytochemistry can be considered as an additional tool to assess the blast OP induced axonal injury.

  2. Reduction of optically observed artillery blast wave trajectories using low dimensionality models

    Science.gov (United States)

    Steward, Bryan J.; Gross, Kevin C.; Perram, Glen P.

    2011-05-01

    Muzzle blast trajectories from firings of a 152 mm caliber gun howitzer were obtained with high-speed optical imagers and used to assess the fidelity with which low dimensionality models can be used for data reduction. Characteristic flow regions were defined for the blast waves. The near-field region was estimated to extend to 0.98 - 1.25 meters from the muzzle and the far-field region was estimated to begin at 2.61 - 3.31 meters. Blast wave geometries and radial trajectories were collected in the near through far-fields with visible imagers operating at 1,600 Hz. Beyond the near-field the blast waves exhibited a near-spherical geometry in which the major axis of the blast lay along the axis of the gun barrel and measured within 95% of the minor axis. Several blast wave propagation models were applied to the mid and far-field data to determine their ability to reduce the blast wave trajectories to fewer parameters while retaining the ability to distinguish amongst three munitions configurations. A total of 147 firings were observed and used to assess within-configuration variability relative to separation between configurations. Results show that all models perform well, and drag and point blast model parameters additionally provide insight into phenomenology of the blast.

  3. Technology Demonstration of Wet Abrasive Blasting for Removal of Lead- and Asbestos-Containing Paint

    National Research Council Canada - National Science Library

    Race, Timothy

    2003-01-01

    ...). This technology demonstration showed that wet blasting using an engineered abrasive can safely and effectively remove lead- and asbestos-containing paint from exterior concrete masonry unit walls...

  4. Investigating the risk of lightning's pressure blast wave

    Directory of Open Access Journals (Sweden)

    Ryan Blumenthal�

    2015-03-01

    Full Text Available We investigated the pathology of human trauma associated with lightning's pressure blast wave. Within what range is a human at risk and what are the risks? Two theories for the trauma currently exist: the flash moisture vaporisation theory and the sixth mechanism theory. We performed a simple proof-of-concept experiment in a high-voltage laboratory to determine which theory makes for better predictions. The experiment confirmed the existence of a non-discriminant pressure blast wave around a spark in air. The lightning data were compared with the known medical data. Findings may now help explain some of the more curious lightning injury patterns seen on lightning-strike victims.

  5. Perspectives on waste minimization with CO2 blasting

    International Nuclear Information System (INIS)

    Krueger, B.E.

    1992-01-01

    Blast-cleaning with dry ice pellets is a technology that has broad applicability for industrial cleaning, surface preparation and decontamination. Alpheus Cleaning Technologies Corp. has pioneered commercial use of this technology with a patented system originally developed by Lockheed Corp. When the dry ice pellets strike the target surface a dual-action cleaning takes place, disappear instantly upon impact, practically eliminating disposal costs. The process is completely dry and can be used on electrical equipment safely. Since there is no grit entrapment or sedimentation residue, in-place cleaning of complex machinery is made possible. Limitations of CO 2 , blasting are that it is a line-of-sight process, it is quite noisy, and the cost of a system exceeds $100,000. Nevertheless, users find they save a great deal of money in pre-cleaning and post-cleaning cost reduction, and the substantial benefits outweigh the other considerations

  6. ACUTE LYMPHOBLASTIC LEUKEMIA WITHOUT CIRCULATING BLASTS PRESENTING AS SEVERE HYPERCALCEMIA

    Directory of Open Access Journals (Sweden)

    Z. Oloomi

    2007-05-01

    Full Text Available Hypercalcemia complicating malignancy is a rare complication in pediatric age group. In this article, we present a case with acute lymphoblastic leukemia presenting as severe hypercalcemia. A 10 years old girl presented with an acute onset of fever, nausea, vomiting, loss of weight, costovertebral pain and frequency. She was admitted with a presumptive diagnosis of acute pyelonephritis. Her examination showed mild hepatosplenomegaly. In laboratory studies she had sever hypercalcemia. Despite the absence of circulating blast, bone marrow aspiration was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and furosemide but the serum calcium levels normalized only after the beginning of specific chemotherapy. Hypercalcemia represents an emergency in children, and acute leukemia must be considered in differential diagnosis even when there are no circulating blasts.

  7. Description of Muzzle Blast by Modified Ideal Scaling Models

    Directory of Open Access Journals (Sweden)

    Kevin S. Fansler

    1998-01-01

    Full Text Available Gun blast data from a large variety of weapons are scaled and presented for both the instantaneous energy release and the constant energy deposition rate models. For both ideal explosion models, similar amounts of data scatter occur for the peak overpressure but the instantaneous energy release model correlated the impulse data significantly better, particularly for the region in front of the gun. Two parameters that characterize gun blast are used in conjunction with the ideal scaling models to improve the data correlation. The gun-emptying parameter works particularly well with the instantaneous energy release model to improve data correlation. In particular, the impulse, especially in the forward direction of the gun, is correlated significantly better using the instantaneous energy release model coupled with the use of the gun-emptying parameter. The use of the Mach disc location parameter improves the correlation only marginally. A predictive model is obtained from the modified instantaneous energy release correlation.

  8. Numerical dynamic analysis of stiffened plates under blast loading

    Directory of Open Access Journals (Sweden)

    H.R. Tavakoli

    Full Text Available Using the general purpose finite element package Abaqus, an investigation has been carried out to examine the dynamic response of steel stiffened plates subjected to uniform blast loading. The main objective of this study is to determine the dynamic response of the stiffened plates considering the effect of stiffener configurations. Several parameters, such as boundary conditions, mesh dependency and strain rate, have been considered in this study. Special emphasis is focused on the evaluation of midpoint displacements and energy of models. The modeling techniques were described in details. The numerical results provide better insight into the effect of stiffener configurations on the nonlinear dynamic response of the stiffened plates subjected to uniform blast loading.

  9. Radio controlled detonators and sequential real time blast applications

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, T.; Laboz, J.M. [Delta Caps International, Nice (France)

    1995-12-31

    Among the numerous technical evolutions in the blasting environment the authors are going to describe below the concept of electronic detonator sequenced by radio waves, and also its numerous applications. Three major technologies are used in the initiation environment: fused-initiated detonators; electric detonators; and non-electric detonators. The last two technologies were made available under multiple variants. Two major innovations are going to substantially change the way traditional detonators operate: pyrotechnic delays are replaced by electronic delays (greater accuracy); and triggering orders, passing through a cable, is now replaced by radio-waves transmission (possibility to do real time delay pattern). Such a new product provided all the features offered by current detonators, but also allows mastering specific cases that were difficult to control with the current technology, such as: vibration control; underground blast; and building demolition.

  10. [Blasting damage in manmade disasters and terrorist attacks].

    Science.gov (United States)

    Shapovalov, V M; Samokhvalov, I M

    2012-01-01

    In the present case of explosive injuries in peacetime, when suddenly there are usually accidental or intentional explosions methane in mines, tanks with gas or explosives, fuel tanks or gas content, gas tanks, gas pipelines, product pipelines, as well as the explosion of military ordnance--grenades, mines, fuses, shells, and accidentally found child or maliciously used by terrorists. Collected statistical data on manmade disasters in coal mines and explosive injuries in terrorist attacks, the physical parameters of which were able to identify only approximately and type of damage incurred,mostly multiple and combinative combined and presented significant challenges in health care. The reasons and circumstances of the explosion in peacetime, gave a detailed description of the damaging factors, mechanisms, and characteristics arise from injuries suffered in the blast injuries. We describe the pathogenesis of blast injury, basic and clinical manifestations of lesions in the explosions.

  11. Soil Stabilisation Using Ground Granulated Blast Furnace Slag

    OpenAIRE

    Ashish Kumar Pathak; Dr. V. Pandey

    2014-01-01

    Stabilisation is a broad sense for the various methods employed and modifying the properties of a soil to improve its engineering performance and used for a variety of engineering works. In today‟s day soil stabilisation is the major problem for civil engineers, either for construction of road and also for increasing the strength or stability of soil and reduces the construction cost. In this thesis the soil are stabilised by ground granulated blast furnace slag (GGBS) and this material is ob...

  12. Controlled drill ampersand blast excavation at AECL's Underground Research Laboratory

    International Nuclear Information System (INIS)

    Kuzyk, G.W.; Onagi, D.P.; Thompson, P.M.

    1996-01-01

    A controlled drill and blast method has been developed and used to excavate the Underground Research Laboratory, a geotechnical facility constructed by Atomic Energy of Canada Limited (AECL) in crystalline rock. It has been demonstrated that the method can effectively reduce the excavation disturbed zone (EDZ) and is suitable for the construction of a used fuel disposal vault in the plutonic rock of the Canadian Shield

  13. Genetic Networks Activated by Blast Injury to the Eye

    Science.gov (United States)

    2018-03-01

    RNA binding protein with multiple splicing) as well as Calb2 (Calbindin 2) and Chrna6 (Cholinergic receptor nicotinic alpha 6). These two networks are...R., O’Neill, H. C., Wageman, C. R., Patzlaff, N. E., et al. (2012). alpha6∗ nicotinic acetylcholine receptor expression and function in a visual...visual function after ocular blast injury can be reduced through immediate-early administration of non-steroidal anti-inflammatory drugs (NSAIDs) such as

  14. Pulmonary effects of combined blast injury and radiation poisoning.

    Science.gov (United States)

    Johnston, A McD

    2004-09-01

    In situations with relatively small numbers of patients with pulmonary blast injury aggressive modern intensive care treatment may allow a return to normal function. The additional effects of radiation poisoning are more difficult to factor in, but new treatments such as colony stimulating factors may improve the outlook for a group with moderate to severe radiation exposure who would previously have died of infection or haemorrhage.

  15. Gene pyramiding enhances durable blast disease resistance in rice

    OpenAIRE

    Fukuoka, Shuichi; Saka, Norikuni; Mizukami, Yuko; Koga, Hironori; Yamanouchi, Utako; Yoshioka, Yosuke; Hayashi, Nagao; Ebana, Kaworu; Mizobuchi, Ritsuko; Yano, Masahiro

    2015-01-01

    Effective control of blast, a devastating fungal disease of rice, would increase and stabilize worldwide food production. Resistance mediated by quantitative trait loci (QTLs), which usually have smaller individual effects than R-genes but confer broad-spectrum or non-race-specific resistance, is a promising alternative to less durable race-specific resistance for crop improvement, yet evidence that validates the impact of QTL combinations (pyramids) on the durability of plant disease resista...

  16. Blast Load Simulator Experiments for Computational Model Validation: Report 1

    Science.gov (United States)

    2016-08-01

    to 2 psi) related to failures of conventional annealed glass and hollow concrete masonry unit walls. It can also simulate higher blast pressures for...Army, Air Force, Navy , and De- fense Special Weapons Agency 1998, Hyde 2003) calculations were con- ducted to produce a waveform that matched both peak...the structures located downstream of the cascade section of the BLS. ERDC/GSL TR-16-27 26 References Department of the Army, Air Force, Navy

  17. Blast furnace coke substitutes from Victorian brown coal

    OpenAIRE

    Mollah, Mamun

    2017-01-01

    Iron is usually produced from its ores using coke in a blast furnace (BF). Coke, a hard and macroporous carbon material, is produced from special coals (coking coals) and acts as fuel, smelting agent, and the permeable support for the charge to the BF. No material can completely replace coke in a BF. Coking coals are becoming harder (and more expensive) to obtain. Victorian brown coal (VBC) is accessible, cheap, with low mineral concentrations, which is favourable for iron production in a BF....

  18. Experimental and Numerical Investigations into Polymeric Coatings for Blast Protection

    Science.gov (United States)

    2011-09-01

    reinforced concrete masonry walls. Subsequent research led to a total of twenty-one off- the-shelf prospective polymers being evaluated to determine the...materials such as fibre reinforced composites which delaminate and break up under such large deformations. A circular area of each of the coated...mechanisms of polymer- reinforced concrete masonry walls subjected to blast. Journal of Structural Engineering 131 (8), pp 1194- 1205 4. Whitlock, C

  19. Summary of IVO participation in Paks blast test analysis

    International Nuclear Information System (INIS)

    Varpasuo, P.

    2001-01-01

    The paper deals with the numerical simulation of the triple blast test performed at Paks NPP. A detailed background analysis was carried out to complete the geological and geotechnical properties and, consequently, special frequency dependent soil stiffnesses have been evaluated. The structural model (3D) allowed a very refined result presentation in terms of profiles of displacements and forces at different elevations, for direct comparison with the experimental output. (author)

  20. The concept of explosives malfunctioning in rock blasting

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Q. [Canada Centre for Mineral and Energy Technology, Val d`Or, Quebec (Canada)

    1994-12-31

    The problem of cross-hole explosive malfunctioning in rock blasting (including sympathetic detonation, desensitization and cut-offs) is a function of delay and spacing in a blast which should be designed to avoid such occurrences. On a delay-spacing chart, the phenomenon of explosive malfunctioning is explained by dividing the chart into different regions, while the shape and size of each region could vary from one explosive to the other. Over seventy blasts have been carried out at the CANMET Experimental Mine to identify the malfunctioning characteristics of specific emulsion, water-gel and dynamite explosives. In each experiment, two parallel blastholes, 32 mm in diameter and 1.7 m deep, were drilled downwards in an underground drift. Full coupling was achieved by tamping the explosives in the wet holes. The receptor hole is initiated with a delay following the donor hole in order to observe the timing effect on the explosives being shocked. High frequency vibration monitoring was used to identify the detonation or failure of the receptor hole. The VOD measurement was used for donor holes but not for the receptor holes because of the cut-off at the collar as a result of donor hole cratering, which was further confirmed with high speed video recording. The spacing is varied to modify the shock pressure the receptor charges are subjected to. Results are presented for the three explosives tested.

  1. Shock initiated reactions of reactive multi-phase blast explosives

    Science.gov (United States)

    Wilson, Dennis; Granier, John; Johnson, Richard; Littrell, Donald

    2017-01-01

    This paper describes a new class of non-ideal explosive compositions made of perfluoropolyether (PFPE), nanoaluminum, and a micron-size, high mass density, reactive metal. Unlike high explosives, these compositions release energy via a fast self-oxidized combustion wave rather than a true self-sustaining detonation. Their reaction rates are shock dependent and they can be overdriven to change their energy release rate. These compositions are fuel rich and have an extended aerobic energy release phase. The term "reactive multiphase blast" refers to the post-dispersion blast behavior: multiphase in that there are a gas phase that imparts pressure and a solid (particulate) phase that imparts energy and momentum [1]; and reactive in that the hot metal particles react with atmospheric oxygen and the explosive gas products to give an extended pressure pulse. Tantalum-based RMBX formulations were tested in two spherical core-shell configurations - an RMBX shell exploded by a high explosive core, and an RMBX core imploded by a high explosive shell. The fireball and blast characteristics were compared to a C-4 baseline charge.

  2. Modelling blast induced damage from a fully coupled explosive charge

    Science.gov (United States)

    Onederra, Italo A.; Furtney, Jason K.; Sellers, Ewan; Iverson, Stephen

    2015-01-01

    This paper presents one of the latest developments in the blasting engineering modelling field—the Hybrid Stress Blasting Model (HSBM). HSBM includes a rock breakage engine to model detonation, wave propagation, rock fragmentation, and muck pile formation. Results from two controlled blasting experiments were used to evaluate the code’s ability to predict the extent of damage. Results indicate that the code is capable of adequately predicting both the extent and shape of the damage zone associated with the influence of point-of-initiation and free-face boundary conditions. Radial fractures extending towards a free face are apparent in the modelling output and matched those mapped after the experiment. In the stage 2 validation experiment, the maximum extent of visible damage was of the order of 1.45 m for the fully coupled 38-mm emulsion charge. Peak radial velocities were predicted within a relative difference of only 1.59% at the nearest history point at 0.3 m from the explosive charge. Discrepancies were larger further away from the charge, with relative differences of −22.4% and −42.9% at distances of 0.46 m and 0.61 m, respectively, meaning that the model overestimated particle velocities at these distances. This attenuation deficiency in the modelling produced an overestimation of the damage zone at the corner of the block due to excessive stress reflections. The extent of visible damage in the immediate vicinity of the blasthole adequately matched the measurements. PMID:26412978

  3. Blast impact behaviour of concrete with different fibre reinforcement

    Directory of Open Access Journals (Sweden)

    Drdlová Martina

    2015-01-01

    Full Text Available The paper summarizes the results of the development of special concrete intended for the explosion resistance applications, with the emphasis on minimal secondary fragments formation at the explosion. The fine-grained concrete matrix has been reinforced by various types of short dispersed fibers (metallic, mineral and polymer of different sizes and by their combination and the effect of the fibre reinforcement on the physico-mechanical properties and blast resistance was observed. The concrete prism specimens have been subjected to the determination of mechanical parameters (compressive and flexural strength at quasi-static load. The blast tests were conducted on the slab specimens prepared from selected mixtures. The material characteristics and explosion test data have been used for numerical investigation, which defined the optimal wall composition and dimensions of the concrete element which should resist the explosion defined by type, size, weight and placement of the blast. In the next step the test elements resistance was verified by real explosion test.

  4. New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080.

    Science.gov (United States)

    Doumith, M; Mushtaq, S; Livermore, D M; Woodford, N

    2016-10-01

    The diazabicyclooctane β-lactamase inhibitor OP0595 (RG6080) also acts as an antibiotic, targeting PBP2 in Enterobacteriaceae, but this activity is vulnerable to mutational resistance. We used WGS to investigate the basis of this resistance. Twenty OP0595-selected mutants, comprising four derived from each of five different Escherichia coli strains, were sequenced on Illumina HiSeq. Reads from each mutant were mapped to the assembled genome of the corresponding parent. A variant-calling file generated with Samtools was parsed to determine genetic alterations. Besides OP0595, the mutants consistently showed decreased susceptibility to mecillinam, which likewise targets PBP2, and grew as stable round forms in the presence of subinhibitory concentrations of OP0595. Among the 20 mutants, 18 had alterations in genes encoding tRNA synthase and modification functions liable to induce expression of the RpoS sigma factor through activation of the stringent response or had mutations suppressing inactivators of RpoS or the stringent response signal-degrading enzyme, SpoT. TolB was inactivated in one mutant: this activates RcsBC regulation and was previously associated with mecillinam resistance. The mechanism of resistance remained unidentified in one mutant. Both the RpoS and RcsBC systems regulate genes of cell division, including ftsAQZ that can compensate for loss or inhibition of PBP2, allowing survival of the challenged bacteria as stable round forms, as seen. WGS identified the global stringent response signal, entailing induction of RpoS, as the main mediator of mutational resistance to OP0595 in E. coli. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Thermodynamic analysis of the partial oxidation of coke oven gas for indirect reduction of iron oxides in a blast furnace

    International Nuclear Information System (INIS)

    Chen, Wei-Hsin; Hsu, Chih-Liang; Du, Shan-Wen

    2015-01-01

    The partial oxidation of a COG (coke oven gas) in a blast furnace is examined in this work using thermodynamic analysis. LTIR and HTIR (Low-temperature and high-temperature indirect reduction) of iron oxides in a blast furnace are also studied. The influences of the reaction temperature, M/H (methane-to-hematite) ratio, and O/F (oxygen-to-fuel) ratio on CH 4 conversion and iron oxide reduction are examined. Within the investigated ranges of the parameters, a higher reaction temperature is conducive to CH 4 conversion, while at least 97.64% of Fe 2 O 3 is reduced. In LTIR, Fe 3 O 4 is the prime product, with a high level of solid carbon formation. The entire LTIR reaction is characterized by exothermic behavior, so that no additional heat is required to trigger COG partial oxidation and IR. In HTIR, increasing the reaction temperature facilitates CO-based IR and suppresses H 2 -based IR. A higher temperature produces more Fe, so as to enhance the iron oxide reduction reactions; meanwhile, the FeO reduction is governed by H 2 and CH 4 . When the reaction temperature is higher than 800 °C and the M/H ratio is lower than unity, a heat supply is required to drive HTIR. The O/F ratio in LTIR and HTIR should be controlled below 2 to retard carbon formation and drive iron oxide reduction. - Highlights: • Direct partial oxidation of coke oven gas in blast furnace is analyzed thermodynamically. • A higher reaction temperature is conducive to CH 4 conversion and syngas production. • At least 97.64% of Fe 2 O 3 is converted. • The low-temperature indirect reduction is characterized by exothermic behavior. • The oxygen-to-fuel molar ratio in indirect reduction should be controlled below 2

  6. BLAST in Gid (BiG): A Grid-Enabled Software Architecture and Implementation of Parallel and Sequential BLAST

    International Nuclear Information System (INIS)

    Aparicio, G.; Blanquer, I.; Hernandez, V.; Segrelles, D.

    2007-01-01

    The integration of High-performance computing tools is a key issue in biomedical research. Many computer-based applications have been migrated to High-Performance computers to deal with their computing and storage needs such as BLAST. However, the use of clusters and computing farm presents problems in scalability. The use of a higher layer of parallelism that splits the task into highly independent long jobs that can be executed in parallel can improve the performance maintaining the efficiency. Grid technologies combined with parallel computing resources are an important enabling technology. This work presents a software architecture for executing BLAST in a International Grid Infrastructure that guarantees security, scalability and fault tolerance. The software architecture is modular an adaptable to many other high-throughput applications, both inside the field of bio computing and outside. (Author)

  7. Computational modeling of blast exposure associated with recoilless weapons combat training

    Science.gov (United States)

    Wiri, S.; Ritter, A. C.; Bailie, J. M.; Needham, C.; Duckworth, J. L.

    2017-11-01

    Military personnel are exposed to blast as part of routine combat training with shoulder-fired recoilless rifles. These weapons fire large-caliber ammunitions capable of disabling structures and uparmored vehicles (e.g., tanks). Scientific, medical, and military leaders are beginning to recognize the blast overpressure from these shoulder-fired weapons may result in acute and even long-term physiological effects to military personnel. However, the back blast generated from the Carl Gustav and Shoulder-launched Multipurpose Assault Weapon (SMAW) shoulder-fired weapons on the weapon operator has not been quantified. By quantifying and modeling the full-body blast exposure from these weapons, better injury correlations can be constructed. Blast exposure data from the Carl Gustav and SMAW were used to calibrate a propellant burn source term for computational simulations of blast exposure on operators of these shoulder-mounted weapon systems. A propellant burn model provided the source term for each weapon to capture blast effects. Blast data from personnel-mounted gauges during weapon firing were used to create initial, high-fidelity 3D computational fluid dynamic simulations using SHAMRC (Second-order Hydrodynamic Automatic Mesh Refinement Code). These models were then improved upon using data collected from static blast sensors positioned around the military personnel while weapons were utilized in actual combat training. The final simulation models for both the Carl Gustav and SMAW were in good agreement with the data collected from the personnel-mounted and static pressure gauges. Using the final simulation results, contour maps were created for peak overpressure and peak overpressure impulse experienced by military personnel firing the weapon as well as those assisting with firing of those weapons. Reconstruction of the full-body blast loading enables a more accurate assessment of the cause of potential mechanisms of injury due to air blast even for subjects not

  8. Effects of low-level blast exposure on the nervous system: Is there really a controversy?

    Directory of Open Access Journals (Sweden)

    Gregory A Elder

    2014-12-01

    Full Text Available High-pressure blast waves can cause extensive CNS injury in humans. However, in combat settings such as Iraq and Afghanistan, lower level exposures associated with mild TBI (mTBI or subclinical exposure have been much more common. Yet controversy exists concerning what traits can be attributed to low-level blast, in large part due to the difficulty of distinguishing blast-related mTBI from post-traumatic stress disorder (PTSD. We describe how TBI is defined in humans and the problems posed in using current definitions to recognize blast-related mTBI. We next consider the problem of applying definitions of human mTBI to animal models, in particular that TBI severity in humans is defined in relation to alteration of consciousness at the time of injury, which typically cannot be assessed in animals. However, based on outcome assessments a condition of low-level blast exposure can be defined in animals that likely approximates human mTBI or subclinical exposure. We review blast injury modeling in animals noting that inconsistencies in experimental approach have contributed to uncertainty over the effects of low-level blast. Yet animal studies show that low-level blast pressure waves are transmitted to the brain. In brain low-level blast exposures cause behavioral, biochemical, pathological and physiological effects on the nervous system including the induction of PTSD-related behavioral traits in the absence of a psychological stressor. We review the relationship of blast exposure to chronic neurodegenerative diseases noting the paradoxical lowering of Abeta by blast, which along with other observations suggest that blast-related TBI is pathophysiologically distinct from non-blast TBI. Human neuroimaging studies show that blast-related mTBI is associated with a variety of chronic effects that are unlikely to be explained by co-morbid PTSD. We conclude that abundant evidence supports low-level blast as having long-term effects on the nervous system.

  9. Numerical modeling anti-personnel blast mines coupled to a deformable leg structure

    Science.gov (United States)

    Cronin, Duane; Worswick, Mike; Williams, Kevin; Bourget, Daniel; Pageau, Gilles

    2001-06-01

    The development of improved landmine protective footwear requires an understanding of the physics and damage mechanisms associated with a close proximity blast event. Numerical models have been developed to model surrogate mines buried in soil using the Arbitrary Lagrangian Eulerian (ALE) technique to model the explosive and surrounding air, while the soil is modeled as a deformable Lagrangian solid. The advantage of the ALE model is the ability to model large deformations, such as the expanding gases of a high explosive. This model has been validated using the available experimental data [1]. The effect of varying depth of burial and soil conditions has been investigated with these numerical models and compares favorably to data in the literature. The surrogate landmine model has been coupled to a numerical model of a Simplified Lower Leg (SLL), which is designed to mimic the response and failure mechanisms of a human leg. The SLL consists of a bone and tissue simulant arranged as concentric cylinders. A new strain-rate dependant hyperelastic material model for the tissue simulant, ballistic gelatin, has been developed to model the tissue simulant response. The polymeric bone simulant material has been characterized and implemented as a strain-rate dependent material in the numerical model. The numerical model results agree with the measured response of the SLL during experimental blast tests [2]. The numerical model results are used to explain the experimental data. These models predict that, for a surface or sub-surface buried anti-personnel mine, the coupling between the mine and SLL is an important effect. In addition, the soil properties have a significant effect on the load transmitted to the leg. [1] Bergeron, D., Walker, R. and Coffey, C., 1998, “Detonation of 100-Gram Anti-Personnel Mine Surrogate Charges in Sand”, Report number SR 668, Defence Research Establishment Suffield, Canada. [2] Bourget, D., Williams, K., Pageau, G., and Cronin, D.,

  10. Assessing Neuro-Systemic & Behavioral Components in the Pathophysiology of Blast-Related Brain Injury

    Directory of Open Access Journals (Sweden)

    Firas H Kobeissy

    2013-11-01

    Full Text Available Among the U.S. military personnel, blast injury is among the leading causes of brain injury. During the past decade, it has become apparent that even blast injury as a form of mild traumatic brain injury (mTBI may lead to multiple different adverse outcomes, such as neuropsychiatric symptoms and long-term cognitive disability. Blast injury is characterized by blast overpressure (BOP, blast duration, and blast impulse. While the blast injuries of a victim close to the explosion will be severe, majority of victims are usually at a distance leading to milder form described as mild blast TBI (mbTBI. A major feature of mbTBI is its complex manifestation occurring in concert at different organ levels involving systemic, cerebral, neuronal and neuropsychiatric responses; some of which are shared with other forms of brain trauma such as acute brain injury and other neuropsychiatric disorders such as PTSD. The pathophysiology of blast injury exposure involves complex cascades of chronic psychological stress, autonomic dysfunction and neuro/systemic inflammation. These factors render blast injury as an arduous challenge in terms of diagnosis and treatment as well as identification of sensitive and specific biomarkers distinguishing mTBI from other non-TBI pathologies and from neuropsychiatric disorders with similar symptoms. This is due to the distinct but shared and partially identified biochemical pathways and neuro-histopathological changes that might be linked to behavioral deficits observed. Taken together, this article aims to provide an overview of the current status of the cellular and pathological mechanisms involved in blast overpressure injury and argues for the urgent need to identify potential biomarkers that can hint at the different mechanisms involved.

  11. Blasting Damage Predictions by Numerical Modeling in Siahbishe Pumped Storage Powerhouse

    Science.gov (United States)

    Eslami, Majid; Goshtasbi, Kamran

    2017-04-01

    One of the popular methods of underground and surface excavations is the use of blasting. Throughout this method of excavation, the loading resulted from blasting can be affected by different geo-mechanical and structural parameters of rock mass. Several factors affect turbulence in underground structures some of which are explosion, vibration, and stress impulses caused by the neighbouring blasting products. In investigating the blasting mechanism one should address the processes which expand with time and cause seismic events. To protect the adjoining structures against any probable deconstruction or damage, it is very important to model the blasting process prior to any actual operation. Efforts have been taken in the present study to demonstrate the potentiality of numerical methods in predicting the specified parameters in order to prevent any probable destruction. For this purpose the blasting process was modeled, according to its natural implementation, in one of the tunnels of Siahbishe dam by the 3DEC and AUTODYN 3D codes. 3DEC was used for modeling the blasting environment as well as the blast holes and AUTODYN 3D for modeling the explosion process in the blast hole. In this process the output of AUTODYN 3D, which is a result of modeling the blast hole and is in the form of stress waves, is entered into 3DEC. For analyzing the amount of destruction made by the blasting operation, the key parameter of Peak Particle Velocity was used. In the end, the numerical modeling results have been compared with the data recorded by the seismographs planted through the tunnel. As the results indicated 3DEC and AUTODYN 3D proved appropriate for analyzing such an issue. Therefore, by means of these two softwares one can analyze explosion processes prior to their implementation and make close estimation of the damage resulting from these processes.

  12. Differences in postinjury auditory system pathophysiology after mild blast and nonblast acute acoustic trauma.

    Science.gov (United States)

    Race, Nicholas; Lai, Jesyin; Shi, Riyi; Bartlett, Edward L

    2017-08-01

    Hearing difficulties are the most commonly reported disabilities among veterans. Blast exposures during explosive events likely play a role, given their propensity to directly damage both peripheral (PAS) and central auditory system (CAS) components. Postblast PAS pathophysiology has been well documented in both clinical case reports and laboratory investigations. In contrast, blast-induced CAS dysfunction remains understudied but has been hypothesized to contribute to an array of common veteran behavioral complaints, including learning, memory, communication, and emotional regulation. This investigation compared the effects of acute blast and nonblast acoustic impulse trauma in adult male Sprague-Dawley rats. An array of audiometric tests were utilized, including distortion product otoacoustic emissions (DPOAE), auditory brain stem responses (ABR), middle latency responses (MLR), and envelope following responses (EFRs). Generally, more severe and persistent postinjury central auditory processing (CAP) deficits were observed in blast-exposed animals throughout the auditory neuraxis, spanning from the cochlea to the cortex. DPOAE and ABR results captured cochlear and auditory nerve/brain stem deficits, respectively. EFRs demonstrated temporal processing impairments suggestive of functional damage to regions in the auditory brain stem and the inferior colliculus. MLRs captured thalamocortical transmission and cortical activation impairments. Taken together, the results suggest blast-induced CAS dysfunction may play a complementary pathophysiological role to maladaptive neuroplasticity of PAS origin. Even mild blasts can produce lasting hearing impairments that can be assessed with noninvasive electrophysiology, allowing these measurements to serve as simple, effective diagnostics. NEW & NOTEWORTHY Blasts exposures often produce hearing difficulties. Although cochlear damage typically occurs, the downstream effects on central auditory processing are less clear

  13. Blast Exposure, White Matter Integrity, and Cognitive Function in Iraq and Afghanistan Combat Veterans

    Directory of Open Access Journals (Sweden)

    Erin A. Hazlett

    2017-04-01

    Full Text Available The long-term effects of blast exposure are a major health concern for combat veterans returning from the recent conflicts in Iraq and Afghanistan. We used an optimized diffusion tensor imaging tractography algorithm to assess white matter (WM fractional anisotropy (FA in blast-exposed Iraq and Afghanistan veterans (n = 40 scanned on average 3.7 years after deployment/trauma exposure. Veterans diagnosed with a blast-related mild traumatic brain injury (mTBI were compared to combat veterans with blast exposure but no TBI diagnosis. Blast exposure was associated with decreased FA in several WM tracts. However, total blast exposure did not correlate well with neuropsychological testing performance and there were no differences in FA based on mTBI diagnosis. Yet, veterans with mTBI performed worse on every neurocognitive test administered. Multiple linear regression across all blast-exposed veterans using a six-factor prediction model indicated that the amount of blast exposure accounted for 11–15% of the variability in composite FA scores such that as blast exposure increased, FA decreased. Education accounted for 10% of the variability in composite FA scores and 25–32% of FA variability in the right cingulum, such that as level of education increased, FA increased. Total blast exposure, age, and education were significant predictors of FA in the left cingulum. We did not find any effect of post-traumatic stress disorder on cognition or composite FA. In summary, our findings suggest that greater total blast exposure is a contributing factor to poor WM integrity. While FA was not associated with neurocognitive performance, we hypothesize that FA changes in the cingulum in veterans with multiple combat exposures and no head trauma prior to deployment may represent a marker of vulnerability for future deficits. Future work needs to examine this longitudinally.

  14. Analysis and Numerical Simulation on the Reduction Effect of Stress Waves Caused by Water Jet Slotting Near Blasting Source

    OpenAIRE

    Su, Dengfeng; Kang, Yong; Li, Dongyang; Wang, Xiaochuan; Yan, Fuwen

    2016-01-01

    As one of the most serious “side effects” of blast excavation, blast-induced vibration must be controlled for existing buildings and human beings. This paper proposes a method for blast-induced vibration reduction with water jet assistance according to the cutting characters of low-noised, environment-friendly water jet. The mechanism of vibration-isolation with water jet assistance was analyzed, and the stress wave energy attenuation models were established based on blasting theory and stres...

  15. Magnetic field measurements of the BLAST spectrometer

    International Nuclear Information System (INIS)

    Dow, Karen A.; Botto, Tancredi; Goodhue, Abigail; Hasell, Douglas; Loughnan, Dylan; Murphy, Kilian; Smith, Timothy Paul; Ziskin, Vitaliy

    2009-01-01

    The Bates Large Acceptance Spectrometer Toroid has been built to study nuclear physics reactions using a stored, polarized electron beam and a variety of polarized targets internal to the storage ring. The spectrometer consists of eight coils surrounding the target cell. There is a requirement of nominally zero field along the centerline of the spectrometer for proper electron beam storage. In addition, the polarized internal targets require a low field gradient in the target region. Magnetic field measurements were made near the beam centerline to guide the alignment of the coils and satisfy the field magnitude and gradient requirements. After the coils were aligned, the magnetic field was measured in the detector regions to provide information for particle tracking.

  16. 75 FR 23589 - Safety Zones; Blasting Operations and Movement of Explosives, St. Marys River, Sault Sainte Marie...

    Science.gov (United States)

    2010-05-04

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zones; Blasting Operations and Movement of... ensure the safety of the maritime community during blasting and dredging operations. DATES: Effective... action is needed to ensure the public's safety during blasting and dredging operations. Delaying the...

  17. 76 FR 71517 - Takes of Marine Mammals During Specified Activities; Blasting Operations by the U.S. Army Corps...

    Science.gov (United States)

    2011-11-18

    ... shall determine the thickness of stemming using blasting industry conventional stemming calculations... marine animals near the blast (Keevin et al., 1999). The visual evidence from a typical confined blast is..., including inshore waters of the bays, sounds, and estuaries. Except for animals residing within the Southern...

  18. Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats

    Science.gov (United States)

    Petrov, Andrey; Wynne, Karon E.; Prough, Donald S.; Dewitt, Douglas S.; Petrov, Yuriy; Petrov, Irene Y.; Parsley, Margaret A.; Esenaliev, Rinat O.

    2014-03-01

    Patients with acute intracranial hematomas often require surgical drainage within the first four hours after traumatic brain injury (TBI) to avoid death or severe neurologic disability. CT and MRI permit rapid, noninvasive diagnosis of hematomas, but can be used only at a major health-care facility. At present, there is no device for noninvasive detection and characterization of hematomas in pre-hospital settings. We proposed to use an optoacoustic technique for rapid, noninvasive diagnosis and monitoring of hematomas, including intracranial hematomas. Unlike bulky CT and MR equipment, an optoacoustic system can be small and easily transported in an emergency vehicle. In this study we used a specially-designed blast device to inflict TBI in rats. A near-infrared OPO-based optoacoustic system developed for hematoma diagnosis and for blood oxygenation monitoring in the superior sagittal sinus (SSS) in small animals was used in the study. Optoacoustic signals recorded simultaneously from the SSS and hematomas allowed for measurements of their oxygenations. The presence of hematomas was confirmed after the experiment in gross pictures of the exposed brains. After blast the hematoma signal and oxygenation increased, while SSS oxygenation decreased due to the blastinduced TBI. The increase of the oxygenation in fresh hematomas may be explained by the leakage of blood from arteries which have higher blood pressure compared to that of veins. These results indicate that the optoacoustic technique can be used for early diagnosis of hematomas and may provide important information for improving outcomes in patients with TBI or stroke (both hemorrhagic and ischemic).

  19. Genetic improvement of resistance to blast and bacterial blight of the ...

    African Journals Online (AJOL)

    Rice blast caused by the fungus Magnaporthe grisea and bacterial blight (BB) caused by Xanthomonas oryzae pv. Oryzae (Xoo) are two major rice diseases in the world. An elite, early maturing maintainer line of hybrid rice, Rongfeng B hybrid rice is susceptible to both blast and BB. For improving its diseases resistance, ...

  20. Induced mutation for disease resistance in rice with special reference to blast, bacterial blight and tungro

    International Nuclear Information System (INIS)

    Mathur, S.C.

    1983-01-01

    Rice varieties Ratna, Pusa 2-21, Vijaya and Pankaj have been treated with gamma rays, EMS or sodium azide to improve their resistance against blast, bacterial leaf blight or tungro virus. For blast and tungro, mutants with improved resistance were selected. Variation in reaction to bacterial leaf blight has been used in crossbreeding to accumulate genes for resistance. (author)

  1. Chronic Hormonal Imbalance and Adipose Redistribution Is Associated with Hypothalamic Neuropathology following Blast Exposure.

    Science.gov (United States)

    VandeVord, Pamela J; Sajja, Venkata Siva Sai Sujith; Ereifej, Evon; Hermundstad, Amy; Mao, Shijie; Hadden, Timothy J

    2016-01-01

    Endocrine disorders have been shown to be a consequence of blast traumatic brain injury in soldiers returning from military conflicts. Hormone deficiency and adrenocorticotropic hormone (ACTH) dysfunction can lead to symptoms such as fatigue, anxiety, irritability, insomnia, sexual dysfunction, and decreased quality of life. Given these changes following blast exposure, the current study focused on investigating chronic pathology within the hypothalamus following blast, in addition to systemic effects. An established rodent model of blast neurotrauma was used to induce mild blast-induced neurotrauma. Adipose tissue, blood, and brain samples were collected at one and three months following a single blast exposure. Adipose tissue and blood were evaluated for changes in ACTH, adiponectin, C-reactive protein, glial fibrillary acidic protein, interleukin (IL)-1β, and leptin. The hypothalamus was evaluated for injury using immunohistochemical techniques. The results demonstrated that the weight of the blast animals was significantly less, compared with the sham group. The slower rate of increase in their weight was associated with changes in ACTH, IL-1β, and leptin levels. Further, histological analysis indicated elevated levels of cleaved caspase-3 positive cells within the hypothalamus. The data suggest that long-term outcomes of brain injury occurring from blast exposure include dysfunction of the hypothalamus, which leads to compromised hormonal function, elevated biological stress-related hormones, and subsequent adipose tissue remodeling.

  2. Model for small arms fire muzzle blast wave propagation in air

    Science.gov (United States)

    Aguilar, Juan R.; Desai, Sachi V.

    2011-11-01

    Accurate modeling of small firearms muzzle blast wave propagation in the far field is critical to predict sound pressure levels, impulse durations and rise times, as functions of propagation distance. Such a task being relevant to a number of military applications including the determination of human response to blast noise, gunfire detection and localization, and gun suppressor design. Herein, a time domain model to predict small arms fire muzzle blast wave propagation is introduced. The model implements a Friedlander wave with finite rise time which diverges spherically from the gun muzzle. Additionally, the effects in blast wave form of thermoviscous and molecular relaxational processes, which are associated with atmospheric absorption of sound were also incorporated in the model. Atmospheric absorption of blast waves is implemented using a time domain recursive formula obtained from numerical integration of corresponding differential equations using a Crank-Nicholson finite difference scheme. Theoretical predictions from our model were compared to previously recorded real world data of muzzle blast wave signatures obtained by shooting a set different sniper weapons of varying calibers. Recordings containing gunfire acoustical signatures were taken at distances between 100 and 600 meters from the gun muzzle. Results shows that predicted blast wave slope and exponential decay agrees well with measured data. Analysis also reveals the persistency of an oscillatory phenomenon after blast overpressure in the recorded wave forms.

  3. New Marker Development for the Rice Blast Resistance Gene Pi-km

    Science.gov (United States)

    The blast resistance (R) gene Pi-km protects rice against specific races of the fungal pathogen Magnaporthe oryzae. The use of blast R genes remains the most cost-effective method of disease control. To facilitate the breeding process, we developed a Pi-km specific molecular marker. For this purp...

  4. Simulation for the powder movement and accumulation in the lower part of blast furnace

    Energy Technology Data Exchange (ETDEWEB)

    Sugiyama, Takashi [Mineral Resources Research Center, Nippon Steel Technoresearch, Futtsu-shi Chiba (Japan)

    1997-12-31

    The behavior of unburnt char and coke powder in the blast furnace becomes material for discussion with the increase in injection rate of pulverized coal into the blast furnace. An analysis was made as to the simulation of powder accumulation at the deadman and dripping zone of blast furnace by using a powder/gas two-phases flow experimental data. When an excessive powder has penetrated at a low gas velocity, it brings an increment in holdup and the controlling factors are powder/gas ratio and gas velocity. An empirical formula used for estimating the powder hold-up in the blast furnace internal conditions has proposed based on similarity. The controlling {pi} numbers are Floude number, powder/gas ratio and particle diameter ratio of powder/lump. This empirical formular was connected with Blast Furnace Total Model `BRIGHT` for the simulation of powder amount distribution in the lower part of blast furnace. When Powder diameter Dk exceeds 100 {mu} and gas velocity becomes lower than 0.7m/s at PC1OOkg/T, the powder tends to accumulate in the deadman. These results was available for the decision of optimum blast conditions and optimum powder diameter in the high amount of pulverized coal injection to the blast furnace. (author) 10 refs.

  5. GPS network observation of traveling ionospheric disturbances following the Chelyabinsk meteorite blast

    Directory of Open Access Journals (Sweden)

    F. Ding

    2016-11-01

    Full Text Available We use the Global Positioning System (GPS network in northwest China and central Asia to monitor traveling ionospheric disturbances (TIDs, which were possibly excited by the large meteorite blast over Chelyabinsk, Russia, on 15 February 2013. Two TIDs were observed. The first TID was observed 13 min after the blast within a range of 270–600 km from the blast site. It propagated radially from the blast site with a mean velocity and period of 369 m s−1 and 12 min, respectively. The second TID was found in northwest China, 1.5 h after the time of the blast, at  ∼  2500–3100 km from the blast site. This latter TID propagated southeastward with a velocity and period of 410 m s−1 and 23 min, respectively. Severe dissipation of the perturbation total electronic content (TEC amplitude was observed. Any TIDs propagating in a global range was not found after the meteorite blast. Features of TIDs were compared with those excited by early nuclear explosion tests. It is inferred from our analysis that the energy release of the Chelyabinsk meteorite blast may not be large enough to excite such ionospheric disturbances in a global range as some nuclear explosions did.

  6. Development of a shot-blasting robot for removal of the wall concrete surface

    International Nuclear Information System (INIS)

    Tokioka, Seigo; Inagaki, Hiroichi; Sakai, Sachio; Kasahara, Ichirou; Ishigami, Shinya

    1991-01-01

    This paper reports research and development of a shot-blasting robot, for which the following targets are set up and their performances confirmed through basic experiments: (1) Uniform removal of concrete surface by an impeller type shot-blasting system. (2) Recycling of projecting material (steel shot). (3) Separation of removal material. And on the basis of these, its application to decontamination of nuclear power facilities is projected. The following three problems were focused on and the results of study are reported as follows: Step 1 : As part of a mechanical basic test, a manual type shot-blasting unit was mounted on a test device which may move freely on the concrete, and its data concerning finishing performance was obtained. Step 2 : On the basis of the results of the mechanization basic test, remote controlling of the shot blasting unit and its mounting on the suction type self-climbing carriage were studied first, secondly data of shot-blasting, operation and control method was gathered to develop a shot-blasting robot. Step 3 : A shot-blasting test was conducted for confirming climbing and shot-blasting performances. (author)

  7. Physics of shock tube simulated IED blast for mTBI research

    NARCIS (Netherlands)

    Mediavilla Varas, J.; Philippens, M.M.G.M.; Meijer, S.R.

    2010-01-01

    The objective of this research is to understand the blast propagation into the human skull and brain causing mTBI and use this knowledge for enabling design of effective protection measures against them. A shock tube including sensor system was optimized to simulate realistic IED blast profiles

  8. Blasting chamber of the mine water stained; Voladuras de avance en labores subterraneas

    Energy Technology Data Exchange (ETDEWEB)

    Domingo Perlado, J. F.

    2012-11-01

    In this paper, the main parameters that lay out a developed blast in underground mining are studied. Such parameters affect the geometry of the draft scheme so as to get a regular cut with a minimum consumption of explosive in order to reduce the vibrations caused by blasting. (Author)

  9. Blasting forward in underground work; Voladuras de camara de la mina de Aguas Tenidas

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Maneiro, C. H.; Maqueda Jimenez, S.; Pazos Perez, L.; Carnero Ortiz, F.

    2012-11-01

    This paper explains the drilling and blasting techniques of stopes in Aguas Tenidas Mine (Huelva, Spain), including slot raises and slots. Highights are: application of electronic detonators and a 30'' hole in slot raise blasts, ANFO uphole chrging of 89 mm holes and high productive fan drillin, in order to maintain stoping production of 150.000 t/month. (Author)

  10. 29 CFR 1926.913 - Blasting in excavation work under compressed air.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Blasting in excavation work under compressed air. 1926.913... Use of Explosives § 1926.913 Blasting in excavation work under compressed air. (a) Detonators and... connecting wires are connected up. (b) When detonators or explosives are brought into an air lock, no...

  11. The g-factor of the electron bound in {sup 28}Si{sup 13+}. The most stringent test of bound-state quantum electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, Sven

    2012-09-06

    This thesis describes the ultra-precise determination of the g-factor of the electron bound to hydrogenlike {sup 28}Si{sup 13+}. The experiment is based on the simultaneous determination of the cyclotron- and Larmor frequency of a single ion, which is stored in a triple Penning-trap setup. The continuous Stern-Gerlach effect is used to couple the spin of the bound electron to the motional frequencies of the ion via a magnetic bottle, which allows the non-destructive determination of the spin state. To this end, a highly sensitive, cryogenic detection system was developed, which allowed the direct, non-destructive detection of the eigenfrequencies with the required precision. The development of a novel, phase sensitive detection technique finally allowed the determination of the g-factor with a relative accuracy of 4 . 10{sup -11}, which was previously inconceivable. The comparison of the hereby determined value with the value predicted by quantumelectrodynamics (QED) allows the verification of the validity of this fundamental theory under the extreme conditions of the strong binding potential of a highly charged ion. The exact agreement of theory and experiment is an impressive demonstration of the exactness of QED. The experimental possibilities created in this work will allow in the near future not only further tests of theory, but also the determination of the mass of the electron with a precision that exceeds the current literature value by more than an order of magnitude.

  12. Waste management system requirements document

    International Nuclear Information System (INIS)

    1991-02-01

    This volume defines the top level requirements for the Mined Geologic Disposal System (MGDS). It is designed to be used in conjunction with Volume 1 of the WMSR, General System Requirements. It provides a functional description expanding the requirements allocated to the MGDS in Volume 1 and elaborates on each requirement by providing associated performance criteria as appropriate. Volumes 1 and 4 of the WMSR provide a minimum set of requirements that must be satisfied by the final MGDS design. This document sets forth specific requirements that must be fulfilled. It is not the intent or purpose of this top level document to describe how each requirement is to be satisfied in the final MGDS design. Each subsequent level of the technical document hierarchy must provide further guidance and definition as to how each of these requirements is to be implemented in the design. It is expected that each subsequent level of requirements will be significantly more detailed. Section 2 of this volume provides a functional description of the MGDS. Each function is addressed in terms of requirements, and performance criteria. Section 3 provides a list of controlling documents. Each document cited in a requirement of Chapter 2 is included in this list and is incorporated into this document as a requirement on the final system. The WMSR addresses only federal requirements (i.e., laws, regulations and DOE orders). State and local requirements are not addressed. However, it will be specifically noted at the potentially affected WMSR requirements that there could be additional or more stringent regulations imposed by a state or local requirements or administering agency over the cited federal requirements

  13. Acoustic monitoring to document the spatial distribution and hotspots of blast fishing in Tanzania.

    Science.gov (United States)

    Braulik, Gill; Wittich, Anja; Macaulay, Jamie; Kasuga, Magreth; Gordon, Jonathan; Davenport, Tim R B; Gillespie, Douglas

    2017-12-15

    Destructive fishing using explosives occurs in a number of countries worldwide, negatively impacting coral reefs and fisheries on which millions of people rely. Documenting, quantifying and combating the problem has proved problematic. In March-April 2015 231h of acoustic data were collected over 2692km of systematically laid transects along the entire coast of Tanzania. A total of 318 blasts were confirmed using a combination of manual and supervised semi-autonomous detection. Blasts were detected along the entire coastline, but almost 62% were within 80km of Dar es Salaam, where blast frequency reached almost 10blasts/h. This study is one of the first to use acoustic monitoring to provide a spatial assessment of the intensity of blast fishing. This can be a useful tool that can provide reliable data to define hotspots where the activity is concentrated and determine where enforcement should be focused for maximum impact. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Comparative Research to Surface Aeration and Blasting Aeration System Based on LCC Theory

    Science.gov (United States)

    Liai, CHEN; Hongxun, HOU; Weibiao, FEI; Eryan, ZHAO

    2017-05-01

    It is difficult to select the suitable aeration system for the designers of wastewater treatment plant (WWTP). In this paper, taking two WWTPs with surface aeration systems and blasting aeration respectively for an example, LCC theory was adapted to analysis the cost of consumption and the environmental impact, which caused by the different aeration system. Research results showed that: (1) In the 20-year life cycle, the LCC mainly depended on the cost of energy consumption whatever blasting aeration system or surface aeration, while the LCC of blasting aeration system affected by the equipment maintenance cost, maintenance cost, economic losses caused by wastewater loss and environmental load in maintenance period. (2) The LCC of blasting aeration system was lower than the surface aeration in general, on the premise of the standard discharge; (3) the blasting aeration system estimated a saving of 60,0000RMB annually in costs compared with the surface aeration.

  15. Reopening of an uranium mine in India after successful pacification of public discontent through cautious blasting

    International Nuclear Information System (INIS)

    Roy, Pijush Pal; Sawmliana, Chhangte; Singh, Rakesh Kumar

    2014-01-01

    Blasting operations at Banduhurang opencast mine of Uranium Corporation of India Limited (UCIL) were stopped for about seven months since February 2011 due to the complaints lodged by the inhabitants of nearby Dhodanga village to the district administration. The complaints were related to the disturbance caused to them as a result of blast- induced ground vibration, noise/air overpressure and flying fragments. On recommendation of the district administration, the Blasting Department of the CSIR-Central Institute of Mining and Fuel Research (CSIR-CIMFR), Dhanbad carried out a thorough scientific study and assessed the impacts of blasting on various residential structures as well as on their inhabitants. The study proved that the impacts of blasting were well within safe limit. It helped pacifying public discontent and ultimately reopening the mine. (author)

  16. X-ray diffractometry of steam cured ordinary Portland and blast-furnace-slag cements

    International Nuclear Information System (INIS)

    Camarini, G.; Djanikian, J.G.

    1994-01-01

    This work studies some aspects of the phases produced by hydration of ordinary and blast-furnace-slag cements, at normal conditions and steam cured (60 and 95 0 C), using an X-ray diffraction technique. The blast-furnace-slag cement was a mixture of 50% of ordinary Portland cement and 50% of blast-furnace-slag (separately grinding). After curing the X-ray diffraction reveals that, in relation to ordinary Portland cement, the main phases in blast-furnace-slag cement are hydrated silicates and aluminates, hydro garnet, etringitte and mono sulphate. After steam curing the hydration of blast-furnace-slag cement proceeds. This is a result of the slag activation by the curing temperature. (author). 8 refs., 3 figs., 1 tab

  17. Middle ear injury in animals exposed to complex blast waves inside an armored vehicle.

    Science.gov (United States)

    Phillips, Y Y; Mundie, T G; Hoyt, R; Dodd, K T

    1989-05-01

    With greater reliance on armored vehicles of improved survivability, questions have arisen about the likelihood of the wounding of vehicle occupants from blast waves alone. In this study, we placed anesthetized animals (sheep or pigs) inside lightly armored vehicles and exposed them to the blast waves generated by one of three sizes of shaped-charge munitions. Sixty-seven animals were exposed and 15 served as controls. No difference was noted between exposed and control groups for blast injury to the respiratory or gastrointestinal tracts. In contrast, middle ear damage was observed exclusively in animals exposed to blast and was correlated strongly with the peak pressure. The ear is the organ most sensitive to blast damage, and if protectors are not used, military physicians can expect to see a high incidence of middle ear injury in modern combat. The operational consequences of such an injury are not known.

  18. Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.

    Science.gov (United States)

    Struebing, Felix L; King, Rebecca; Li, Ying; Chrenek, Micah A; Lyuboslavsky, Polina N; Sidhu, Curran S; Iuvone, P Michael; Geisert, Eldon E

    2018-01-01

    Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast injury. We observe that almost 40% of genes are differentially expressed with a false discovery rate (FDR) of immune system are activated. Accompanied by lymphocyte invasion into the inner retina, blast injury also results in progressive loss of visual function and retinal ganglion cells (RGCs). Collectively, these data demonstrate how systems genetics can be used to put meaning to the transcriptome changes following ocular blast injury that eventually lead to blindness.

  19. Application of full-face round by the sequential blasting machine in tunnel excavation

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Y.D.; Park, B.K.; Lee, S.E.; Lim, H.U.

    1995-12-31

    Many methods and techniques have been developed to reduce ground vibrations. Some of them are an adoption of electric millisecond detonators with a sequential blasting machine and an improvement of initiating system with an adequate number of delay intervals. To reduce the level of ground vibration in tunnel excavation, the sequential blasting machine (S.B.M.) with decisecond detonators was adopted. A total of 134 blasts was recorded at various sites and the results were analyzed. The distances blast-to-structures were ranged from 20.3 to 42.0 meter, where charge weights were varied from 0.25 to 0.75kg per delay. It is proved that the sequential blasting in tunnel excavation is very effective to control ground vibration.

  20. CRISPR/Cas9-Mediated Gene Editing in Rice (Oryza sativa L. japonica cv. Katy) for Stable Resistance against Blast Fungus (Magnaporthe oryzae)

    Science.gov (United States)

    Rice blast is a recurring and devastating disease in the USA and worldwide. In the USA, the blast-resistance (R) genes found in a tropical japonica cultivar, Katy, reduce blast damages from 1990 to present. The cultivar is still used as a principal donor of blast R genes in developing numerous elit...

  1. Experimental Extinguishment of Fires by Blast.

    Science.gov (United States)

    1982-05-01

    thermal radiation source is required for use with the shocktube. SRI shall complete the fabrication of a multimodule, electrically heated graphite-strip...conveniently aqjusta~le in 30% increments up to at least 15 cal cm sec b. Minimum pulse rise time--1 to 2 seconds at maximum electrical power...Suite 104 Attn: ENGENE -RD Palo Alto, California 94303 Washington, D. C. 20314 Director, Defense Nuclear Agency Mr. Walser (Jerry) Strops Attn: Tom

  2. Simultaneous utilization of neutrons and γ-rays from 252Cf for condition measurement inside a blast furnace

    International Nuclear Information System (INIS)

    Shirakawa, Yoshiyuki; Tominaga, Hiroshi.

    1997-01-01

    This paper describes the possibility of the realization of a multi-function radiation gauge to meet the requirement for more precise and stable control of a blast furnace. A basic concept of the gauge is to measure some quantities with simultaneous use of multi-radiations of neutrons and γ-rays, and to obtain multi-types of information on material flow and gas flow representing the conditions inside the blast furnace. The prototype gauge was assembled and examined which consisted of a radiation source of 252 Cf (3.7 MBq), neutron moderator, lead shield, a bismuth germanate detector, stainless casing and a control unit. Laboratory experiments showed that the gauge could measure the quantities to be essential to estimate the blast furnace conditions. In practice, it clearly distinguished between iron ore and coke layers, and at the same time measured bulk density (1.0-1.5 g/cm 3 ) of iron contained in iron ore by counting thermal neutron capture γ-rays (6.5-8.5 MeV) from iron. It also gave the information on material bulk density (0.5-2.5 g/cm 3 ) by detecting Compton scattered γ-rays (1.0-1.5 MeV) from material, i.e. iron ore and coke. The relative accuracies in the measurement of iron bulk density and material bulk density were estimated to be within 1 and 4% in 300 s counting time, respectively. The possibility of the gauge has been proved and the on-line trial will be expected in the near future. (author)

  3. Evidence for a transketolase-mediated metabolic checkpoint governing biotrophic growth in rice cells by the blast fungus Magnaporthe oryzae.

    Directory of Open Access Journals (Sweden)

    Jessie Fernandez

    2014-09-01

    Full Text Available The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through the rice cuticle and into the underlying epidermal cells, where the fungus grows for the first days of infection as a symptomless biotroph. Understanding what controls biotrophic growth could open new avenues for developing sustainable blast intervention programs. Here, using molecular genetics and live-cell imaging, we dismantled M. oryzae glucose-metabolizing pathways to reveal that the transketolase enzyme, encoded by TKL1, plays an essential role in facilitating host colonization during rice blast disease. In the absence of transketolase, Δtkl1 mutant strains formed functional appressoria that penetrated rice cuticles successfully and developed invasive hyphae (IH in rice cells from primary hyphae. However, Δtkl1 could not undertake sustained biotrophic growth or cell-to-cell movement. Transcript data and observations using fluorescently labeled histone H1:RFP fusion proteins indicated Δtkl1 mutant strains were alive in host cells but were delayed in mitosis. Mitotic delay could be reversed and IH growth restored by the addition of exogenous ATP, a metabolite depleted in Δtkl1 mutant strains. We show that ATP might act via the TOR signaling pathway, and TOR is likely a downstream target of activation for TKL1. TKL1 is also involved in controlling the migration of appressorial nuclei into primary hyphae in host cells. When taken together, our results indicate transketolase has a novel role in mediating--via ATP and TOR signaling--an in planta-specific metabolic checkpoint that controls nuclear migration from appressoria into primary hyphae, prevents mitotic delay in early IH and promotes biotrophic growth. This work thus provides new information about the metabolic strategies employed by M

  4. The central dynamics of M3, M13, and M92: stringent limits on the masses of intermediate-mass black holes

    Science.gov (United States)

    Kamann, S.; Wisotzki, L.; Roth, M. M.; Gerssen, J.; Husser, T.-O.; Sandin, C.; Weilbacher, P.

    2014-06-01

    We used the PMAS integral field spectrograph to obtain large sets of radial velocities in the central regions of three northern Galactic globular clusters: M3, M13, and M92. By applying the novel technique of crowded field 3D spectroscopy, we measured radial velocities for about 80 stars within the central ~10″ of each cluster. These are by far the largest spectroscopic datasets obtained in the innermost parts of these clusters up to now. To obtain kinematical data across the whole extent of the clusters, we complement our data with measurements available in the literature. We combine our velocity measurements with surface brightness profiles to analyse the internal dynamics of each cluster using spherical Jeans models, and investigate whether our data provide evidence for an intermediate-mass black hole in any of the clusters. The surface brightness profiles reveal that all three clusters are consistent with a core profile, although shallow cusps cannot be excluded. We find that spherical Jeans models with a constant mass-to-light ratio provide a good overall representation of the kinematical data. A massive black hole is required in none of the three clusters to explain the observed kinematics. Our 1σ (3σ) upper limits are 5300 M⊙ (12 000 M⊙) for M3, 8600 M⊙ (13 000 M⊙) for M13, and 980 M⊙ (2700 M⊙) for M92. A puzzling circumstance is the existence of several potential high velocity stars in M3 and M13, as their presence can account for the majority of the discrepancies that we find in our mass limits compared to M92. Based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).Appendices are available in electronic form at http://www.aanda.orgTables D.1 to D.6 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc

  5. Economic and Environmental Impact of Rice Blast Pathogen (Magnaporthe oryzae) Alleviation in the United States.

    Science.gov (United States)

    Nalley, Lawton; Tsiboe, Francis; Durand-Morat, Alvaro; Shew, Aaron; Thoma, Greg

    2016-01-01

    Rice blast (Magnaporthe oryzae) is a key concern in combating global food insecurity given the disease is responsible for approximately 30% of rice production losses globally-the equivalent of feeding 60 million people. These losses increase the global rice price and reduce consumer welfare and food security. Rice is the staple crop for more than half the world's population so any reduction in rice blast would have substantial beneficial effects on consumer livelihoods. In 2012, researchers in the US began analyzing the feasibility of creating blast-resistant rice through cisgenic breeding. Correspondingly, our study evaluates the changes in producer, consumer, and environmental welfare, if all the rice produced in the Mid-South of the US were blast resistant through a process like cisgenics, using both international trade and environmental assessment modeling. Our results show that US rice producers would gain 69.34 million dollars annually and increase the rice supply to feed an additional one million consumers globally by eliminating blast from production in the Mid-South. These results suggest that blast alleviation could be even more significant in increasing global food security given that the US is a small rice producer by global standards and likely experiences lower losses from blast than other rice-producing countries because of its ongoing investment in production technology and management. Furthermore, results from our detailed life cycle assessment (LCA) show that producing blast-resistant rice has lower environmental (fossil fuel depletion, ecotoxicity, carcinogenics, eutrophication, acidification, global warming potential, and ozone depletion) impacts per unit of rice than non-blast resistant rice production. Our findings suggest that any reduction in blast via breeding will have significantly positive impacts on reducing global food insecurity through increased supply, as well as decreased price and environmental impacts in production.

  6. Economic and Environmental Impact of Rice Blast Pathogen (Magnaporthe oryzae Alleviation in the United States.

    Directory of Open Access Journals (Sweden)

    Lawton Nalley

    Full Text Available Rice blast (Magnaporthe oryzae is a key concern in combating global food insecurity given the disease is responsible for approximately 30% of rice production losses globally-the equivalent of feeding 60 million people. These losses increase the global rice price and reduce consumer welfare and food security. Rice is the staple crop for more than half the world's population so any reduction in rice blast would have substantial beneficial effects on consumer livelihoods. In 2012, researchers in the US began analyzing the feasibility of creating blast-resistant rice through cisgenic breeding. Correspondingly, our study evaluates the changes in producer, consumer, and environmental welfare, if all the rice produced in the Mid-South of the US were blast resistant through a process like cisgenics, using both international trade and environmental assessment modeling. Our results show that US rice producers would gain 69.34 million dollars annually and increase the rice supply to feed an additional one million consumers globally by eliminating blast from production in the Mid-South. These results suggest that blast alleviation could be even more significant in increasing global food security given that the US is a small rice producer by global standards and likely experiences lower losses from blast than other rice-producing countries because of its ongoing investment in production technology and management. Furthermore, results from our detailed life cycle assessment (LCA show that producing blast-resistant rice has lower environmental (fossil fuel depletion, ecotoxicity, carcinogenics, eutrophication, acidification, global warming potential, and ozone depletion impacts per unit of rice than non-blast resistant rice production. Our findings suggest that any reduction in blast via breeding will have significantly positive impacts on reducing global food insecurity through increased supply, as well as decreased price and environmental impacts in

  7. The importance of systemic response in the pathobiology of blast-induced neurotrauma

    Directory of Open Access Journals (Sweden)

    Ibolja eCernak

    2010-12-01

    Full Text Available Due to complex injurious environment where multiple blast effects interact with the body, parallel blast-induced neurotrauma is a unique clinical entity induced by systemic, local, and cerebral responses. Activation of autonomous nervous system; sudden pressure-increase in vital organs such as lungs and liver; and activation of neuroendocrine-immune system are among the most important mechanisms that contribute significantly to molecular changes and cascading injury mechanisms in the brain. It has been hypothesized that vagally mediated cerebral effects play a vital role in the early response to blast: this assumption has been supported by experiments where bilateral vagotomy mitigated bradycardia, hypotension, and apnea, and also prevented excessive metabolic alterations in the brain of animals exposed to blast. Clinical experience suggests specific blast-body-nervous system interactions such as 1 direct interaction with the head either through direct passage of the blast wave through the skull or by causing acceleration and/or rotation of the head; and 2 via hydraulic interaction, when the blast overpressure compresses the abdomen and chest, and transfers its kinetic energy to the body’s fluid phase, initiating oscillating waves that traverse the body and reach the brain. Accumulating evidence suggests that inflammation plays important role in the pathogenesis of long-term neurological deficits due to blast. These include memory decline, motor function and balance impairments, and behavioral alterations, among others. Experiments using rigid body- or head protection in animals subjected to blast showed that head protection failed to prevent inflammation in the brain or reduce neurological deficits, whereas body protection was successful in alleviating the blast-induced functional and morphological impairments in the brain.

  8. Bit-Blasting ACL2 Theorems

    Directory of Open Access Journals (Sweden)

    Sol Swords

    2011-10-01

    Full Text Available Interactive theorem proving requires a lot of human guidance. Proving a property involves (1 figuring out why it holds, then (2 coaxing the theorem prover into believing it. Both steps can take a long time. We explain how to use GL, a framework for proving finite ACL2 theorems with BDD- or SAT-based reasoning. This approach makes it unnecessary to deeply understand why a property is true, and automates the process of admitting it as a theorem. We use GL at Centaur Technology to verify execution units for x86 integer, MMX, SSE, and floating-point arithmetic.

  9. Acid slag injection into the blast furnace tuyere zone

    Energy Technology Data Exchange (ETDEWEB)

    Haerkki, J.; Tervola, K. [Oulu Univ. (Finland). Dept. of Process Engineering

    1996-12-31

    The possibility of acid slag injection and its effect on the slag formation and on the melting behaviour of the charge materials are studied in the present work. The work is partly based on the literature evaluating the slag formation, slag properties and the basic slag injection. The possibility of acid slag injection is first examined by studying changes in the composition of the primary slag if the share of the acid slag component (Kostamus pellet/RR) of the charge material is lowered. Phase diagrams and viscosity charts are used to evaluate the viscosity, and solidus/liquidus temperature in the slag phase. The share of the slag phase of the pellet is evaluated by calculating the amount of the acid slag injection. The injection rate of some injectants is also examined. The primary slag formed of the sinter and the coke ash is in liquid form and its viscosity is close to the viscosity of the blast furnace slag. It is possible that the liquid slag phase can be formed in the blast furnace without the presence of the acid pellet because the melting point and the viscosity of the slag is lowered by alkalies, sulfur and the dissolved ironoxide of the slag. If high SiO{sub 2} content materials alone are used for injection there is a risk that the slag phase of the tuyere zone becomes too viscous. Olivine and some iron containing components such as fayalite are possible injection material. More information is needed to evaluate the effect of acid slag injection on the operation of the blast furnace. (orig.) SULA 2 Research Programme; 2 refs.

  10. SUBMILLIMETER NUMBER COUNTS FROM STATISTICAL ANALYSIS OF BLAST MAPS

    International Nuclear Information System (INIS)

    Patanchon, Guillaume; Ade, Peter A. R.; Griffin, Matthew; Hargrave, Peter C.; Mauskopf, Philip; Moncelsi, Lorenzo; Pascale, Enzo; Bock, James J.; Chapin, Edward L.; Halpern, Mark; Marsden, Gaelen; Scott, Douglas; Devlin, Mark J.; Dicker, Simon R.; Klein, Jeff; Rex, Marie; Gundersen, Joshua O.; Hughes, David H.; Netterfield, Calvin B.; Olmi, Luca

    2009-01-01

    We describe the application of a statistical method to estimate submillimeter galaxy number counts from confusion-limited observations by the Balloon-borne Large Aperture Submillimeter Telescope (BLAST). Our method is based on a maximum likelihood fit to the pixel histogram, sometimes called 'P(D)', an approach which has been used before to probe faint counts, the difference being that here we advocate its use even for sources with relatively high signal-to-noise ratios. This method has an advantage over standard techniques of source extraction in providing an unbiased estimate of the counts from the bright end down to flux densities well below the confusion limit. We specifically analyze BLAST observations of a roughly 10 deg 2 map centered on the Great Observatories Origins Deep Survey South field. We provide estimates of number counts at the three BLAST wavelengths 250, 350, and 500 μm; instead of counting sources in flux bins we estimate the counts at several flux density nodes connected with power laws. We observe a generally very steep slope for the counts of about -3.7 at 250 μm, and -4.5 at 350 and 500 μm, over the range ∼0.02-0.5 Jy, breaking to a shallower slope below about 0.015 Jy at all three wavelengths. We also describe how to estimate the uncertainties and correlations in this method so that the results can be used for model-fitting. This method should be well suited for analysis of data from the Herschel satellite.

  11. The Vestibular Effects of Repeated Low-Level Blasts.

    Science.gov (United States)

    Littlefield, Philip D; Pinto, Robin L; Burrows, Holly L; Brungart, Douglas S

    2016-01-01

    The objective of this study was to use a prospective cohort of United States Marine Corps (USMC) instructors to identify any acute or long-term vestibular dysfunction following repeated blast exposures during explosive breaching training. They were assessed in clinic and on location during training at the USMC Methods of Entry School, Quantico, VA. Subjects received comprehensive baseline vestibular assessments and these were repeated in order to identify longitudinal changes. They also received shorter assessments immediately following blast exposure in order to identify acute findings. The main outcome measures were the Neurobehavioral Symptom Inventory, vestibular Visual Analog Scale (VAS) of subjective vestibular function, videonystagmography (VNG), vestibular evoked myogenic potentials (VEMP), rotary chair (including the unilateral centrifugation test), computerized dynamic posturography, and computerized dynamic visual acuity. A total of 11 breachers and 4 engineers were followed for up to 17 months. No acute effects or longitudinal deteriorations were identified, but there were some interesting baseline group differences. Upbeat positional nystagmus was common, and correlated (p<0.005) with a history of mild traumatic brain injury (mTBI). Several instructors had abnormally short low-frequency phase leads on rotary chair testing. This study evaluated breaching instructors over a longer test period than any other study, and the results suggest that this population appears to be safe from a vestibular standpoint at the current exposure levels. Upbeat positional nystagmus correlated with a history of mTBI in this population, and this has not been described elsewhere. The data trends also suggest that this nystagmus could be an acute blast effect. However, the reasons for the abnormally short phase leads seen in rotary chair testing are unclear at this time. Further investigation seems warranted.

  12. Spectral properties of Seismic waves during quarry blasts

    Czech Academy of Sciences Publication Activity Database

    Holub, Karel; Knejzlík, Jaromír; Rušajová, Jana

    2006-01-01

    Roč. 6, č. 2 (2006), s. 133-141 ISSN 1213-1962. [Nové poznatky a měření v seismologii, inženýrské geofyzice a geotechnice/15./. Ostrava, 11.04.2006-13.04.2006] R&D Projects: GA ČR GA205/03/0999 Institutional research plan: CEZ:AV0Z30860518 Keywords : quarry blasts * spectral analysis * body and surface waves Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  13. Performance Evaluation Of Modified V-Blast In Mimo System

    Science.gov (United States)

    Suneetha, Ch.; Harathi, N.; Sudha, K.

    2012-03-01

    The MIMO system (multiple Antennas at the transmitter and receiver)is a capable of very high theoretical capacities, the most popular architecture is so called vertical VBLAST. VBLAST is an effective detection method for MIMO communication system, but has large computational complexity due its successive iteration . In this paper we used modified VBLAST to lessen its computational complexity reducing the number of successive iterations. As a result of this simplification, the computational complexity of the detection is lowered significantly. Simulation results show that the proposed V-BLAST reduces calculation complexity by about 30% while achieving a very close BER performance s the original one.

  14. Cleaning By Blasting With Pellets Of Dry Ice

    Science.gov (United States)

    Fody, Jody

    1993-01-01

    Dry process strips protective surface coats from parts to be cleaned, without manual scrubbing. Does not involve use of flammable or toxic solvents. Used to remove coats from variety of materials, including plastics, ceramics, ferrous and nonferrous metals, and composites. Adds no chemical-pollution problem to problem of disposal of residue of coating material. Process consists of blasting solid carbon dioxide (dry ice) pellets at surface to be cleaned. Pellets sublime on impact and pass into atmosphere as carbon dioxide gas. Size, harness, velocity, and quantity of pellets adjusted to suit coating material and substrate.

  15. Experiments on cylindrically converging blast waves in atmospheric air

    Science.gov (United States)

    Matsuo, Hideo; Nakamura, Yuichi

    1980-06-01

    Cylindrically converging blast waves have been produced in normal atmospheric conditions by the detonation of the explosives, pentaerythritoltetranitrate, (PETN), over cylindrical surfaces. The shocks generated in this way are so strong that the fronts propagating through the air become luminous of themselves. The production and the propagation of the shocks have been monitored with a framing camera and a streak camera, and the time-space relations of the shock propagations have been determined using an electrical ionization probing system. The results have shown that the trajectory of the shock fronts near the axis of the cylinder can be approximately represented by the Guderley's formula.

  16. Internal Jugular Vein Compression: A Novel Approach to Mitigate Blast Induced Hearing Injury.

    Science.gov (United States)

    Sindelar, Brian; Shinners, Michael; Sherman, Sydney; Novak, Kevin; Erickson, Kristine; Patel, Vimal; Kubilis, Paul; Smith, David; Finan, John; Bailes, Julian E

    2017-04-01

    Internal jugular vein (IJV) compression before blast injury will lead to reduced risk of traumatic hearing injury following exposure to a blast injury. IJV compression and its effects on not only intracranial, but also intracochlear pressure may potentiate blast induced hearing injury, therefore, precluding its use as a prophylactic therapy for blast induced traumatic brain injury. Twenty Sprague Dawley rats were exposed to a 17.9 ± 0.4 PSI (195.8 dB SPL) right sided shock wave in which 10 had application of a custom IJV compression collar before injury. All rodents received baseline and post blast injury otoacoustic emission (OAE) and auditory brainstem response (ABR) testing followed by cochlear histology. IJV compression was shown to significantly reduce ABR and OAE threshold shifts in comparison to the non-intervention group by: 14.9 ± 4.8 dB (right ear ABR 0.5 kHz Day 1 post blast, p = 0.01), 13.1 ± 4.9 dB (right ear ABR 4 kHz Day 1 post blast, p = 0.04), 16.5 ± 4.5 dB (right ear ABR click Day 1 post blast, p = 0.003), 12.1 ± 4.6 dB (right ear ABR click Day 6 post blast, p = 0.04), and 14.0 ± 3.2 dB (both ears OAE 3.2-10 kHz, p collar application had a greater number of total hair cells per mm from 70 to 100% distance from the cochlear apex following blast injury in comparison to those without intervention (blast: 211.8 ± 27.5 versus blast+collar: 355.5 ± 39.5 [p = 0.0002]). This study supports the use of IJV compression in a pre-clinical model as a new prophylactic mechanism to combat blast induced hearing injury.

  17. Behavioral Outcomes Differ Between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury

    Directory of Open Access Journals (Sweden)

    Brian D. Stemper

    2016-03-01

    Full Text Available Mild traumatic brain injury (mTBI can result from a number of mechanisms, including blunt impact, head rotational acceleration, exposure to blast, and penetration of projectiles. Mechanism is likely to influence the type, severity, and chronicity of outcomes. The objective of this study was to determine differences in the severity and time-course of behavioral outcomes following blast and rotational mTBI. The Medical College of Wisconsin (MCW Rotational Injury model and a shock tube model of primary blast injury were used to induce mTBI in rats and behavioral assessments were conducted within the first week, as well as 30 and 60 days following injury. Acute recovery time demonstrated similar increases over protocol-matched shams, indicating acute injury severity equivalence between the two mechanisms. Post-injury behavior in the elevated plus maze demonstrated differing trends, with rotationally injured rats acutely demonstrating greater activity, whereas blast-injured rats had decreased activity that developed at chronic time points. Similarly, blast-injured rats demonstrated trends associated with cognitive deficits that were not apparent following rotational injuries. These findings demonstrate that rotational and blast injury result in behavioral changes with different qualitative and temporal manifestations. Whereas rotational injury was characterized by a rapidly emerging phenotype consistent with behavioral disinhibition, blast injury was associated with emotional and cognitive differences that were not evident acutely, but developed later, with an anxiety-like phenotype still present in injured animals at our most chronic measurements.

  18. Mild blast events alter anxiety, memory, and neural activity patterns in the anterior cingulate cortex.

    Directory of Open Access Journals (Sweden)

    Kun Xie

    Full Text Available There is a general interest in understanding of whether and how exposure to emotionally traumatizing events can alter memory function and anxiety behaviors. Here we have developed a novel laboratory-version of mild blast exposure comprised of high decibel bomb explosion sound coupled with strong air blast to mice. This model allows us to isolate the effects of emotionally fearful components from those of traumatic brain injury or bodily injury typical associated with bomb blasts. We demonstrate that this mild blast exposure is capable of impairing object recognition memory, increasing anxiety in elevated O-maze test, and resulting contextual generalization. Our in vivo neural ensemble recording reveal that such mild blast exposures produced diverse firing changes in the anterior cingulate cortex, a region processing emotional memory and inhibitory control. Moreover, we show that these real-time neural ensemble patterns underwent post-event reverberations, indicating rapid consolidation of those fearful experiences. Identification of blast-induced neural activity changes in the frontal brain may allow us to better understand how mild blast experiences result in abnormal changes in memory functions and excessive fear generalization related to post-traumatic stress disorder.

  19. Viscoelastic Materials Study for the Mitigation of Blast-Related Brain Injury

    Science.gov (United States)

    Bartyczak, Susan; Mock, Willis, Jr.

    2011-06-01

    Recent preliminary research into the causes of blast-related brain injury indicates that exposure to blast pressures, such as from IED detonation or multiple firings of a weapon, causes damage to brain tissue resulting in Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD). Current combat helmets are not sufficient to protect the warfighter from this danger and the effects are debilitating, costly, and long-lasting. Commercially available viscoelastic materials, designed to dampen vibration caused by shock waves, might be useful as helmet liners to dampen blast waves. The objective of this research is to develop an experimental technique to test these commercially available materials when subject to blast waves and evaluate their blast mitigating behavior. A 40-mm-bore gas gun is being used as a shock tube to generate blast waves (ranging from 1 to 500 psi) in a test fixture at the gun muzzle. A fast opening valve is used to release nitrogen gas from the breech to impact instrumented targets. The targets consist of aluminum/ viscoelastic polymer/ aluminum materials. Blast attenuation is determined through the measurement of pressure and accelerometer data in front of and behind the target. The experimental technique, calibration and checkout procedures, and results will be presented.

  20. Experimental Study of the Jet Engine Exhaust Flow Field of Aircraft and Blast Fences

    Directory of Open Access Journals (Sweden)

    Haifu Wang

    2015-04-01

    Full Text Available A combined blast fence is introduced in this paper to improve the solid blast fences and louvered ones. Experiments of the jet engine exhaust flow (hereinafter jet flow for short field and tests of three kinds of blast fences in two positions were carried out. The results show that the pressure and temperature at the centre of the jet flow decrease gradually as the flow moves farther away from the nozzle. The pressure falls fast with the maximum rate of 41.7%. The dynamic pressure 150 m away from the nozzle could reach 58.8 Pa, with a corresponding wind velocity of 10 m/s. The temperature affected range of 40°C is 113.5×20 m. The combined blast fence not only reduces the pressure of the flow in front of it but also solves the problems that the turbulence is too strong behind the solid blast fences and the pressure is too high behind the louvered blast fences. And the pressure behind combined blast fence is less than 10 Pa. The height of the fence is related to the distance from the jet nozzle. The nearer the fence is to the nozzle, the higher it is. When it is farther from the nozzle, its height can be lowered.

  1. Kekasaran Permukaan Baja Karbon Sedang Akibat Proses Sand-Blasting dengan Variasi Jarak Nosel

    Directory of Open Access Journals (Sweden)

    I Made Widiyarta

    2016-07-01

    Full Text Available Abstrak: Proses sand-blasting merupakan proses yang dilakuan untuk membersihkan dan merubah kekasaran permukaan material. Proses ini umumnya dilakukan sebelum melakukan proses pelapisan permukaan material dengan tujuan untuk meningkatkan daya rekat lapisan pada permukaan material yang dilapisi. Pada penelitian ini, proses sand-blasting dilakukan pada baja karbon sedang dengan variasi jarak nosel untuk memperoleh perubahan kekasaran permukaan material. Hasil pengujian menunjukkan perubahan jarak nosel pada proses sand-blasting memberikan pengaruh yang cukup signifikan pada kekasaran permukaan. Kata kunci: sand-blasting, baja karbon sedang, kekasaran permukaan Abstract: Sand-blasting is a process of surfaces treatment to clean and to roughen surface of material. This process is commonly used in preparing the surface before the coating process in order to increase the bond strength of the coating material on the surface of substrate material. In this work, sand-blasting process is conducted to the medium carbon steel with varying nozzle distance to the surface of material. The experiment results show the different nozzle distance causes the change of surface roughness significantly. Keywords: sand-blasting, carbon steel, surface roughness

  2. Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats.

    Science.gov (United States)

    Sajja, Venkata Siva Sai Sujith; Perrine, Shane A; Ghoddoussi, Farhad; Hall, Christina S; Galloway, Matthew P; VandeVord, Pamela J

    2014-03-01

    Working memory, which is dependent on higher-order executive function in the prefrontal cortex, is often disrupted in patients exposed to blast overpressure. In this study, we evaluated working memory and medial prefrontal neurochemical status in a rat model of blast neurotrauma. Adult male Sprague-Dawley rats were anesthetized with 3% isoflurane and exposed to calibrated blast overpressure (17 psi, 117 kPa) while sham animals received only anesthesia. Early neurochemical effects in the prefrontal cortex included a significant decrease in betaine (trimethylglycine) and an increase in GABA at 24 h, and significant increases in glycerophosphorylcholine, phosphorylethanolamine, as well as glutamate/creatine and lactate/creatine ratios at 48 h. Seven days after blast, only myo-inositol levels were altered showing a 15% increase. Compared to controls, short-term memory in the novel object recognition task was significantly impaired in animals exposed to blast overpressure. Working memory in control animals was negatively correlated with myo-inositol levels (r=-.759, p<0.05), an association that was absent in blast exposed animals. Increased myo-inositol may represent tardive glial scarring in the prefrontal cortex, a notion supported by GFAP changes in this region after blast overexposure as well as clinical reports of increased myo-inositol in disorders of memory. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Investigation of Axial Strengthened Reinforced Concrete Columns under Lateral Blast Loading

    Directory of Open Access Journals (Sweden)

    Mohammad Esmaeilnia Omran

    2017-01-01

    Full Text Available Different factors can affect blast response of structural components. Hence, experimental tests could be the best method for evaluating structures under blast loading. Therefore, an experimental explosion loading has been done on RC members by the authors. Four RC components, with identical geometry and material, with and without axial load were imposed to air blast. Observed data of the members’ response under blast loading was used for validation of finite element modeling process using ABAQUS software. With respect to complexity, limitations, and high costs of experimental tests, analytical studies and software modeling can be good alternatives. Accordingly, in this paper, the behavior of 6 different models of normal and strengthened RC columns under blast loading was evaluated using ABAQUS. Strengthening configurations considered here were designed for enhancing axial capacity of RC columns. Therefore, we can investigate the effectiveness of axial strengthening of column on its blast resistance capacity and residual axial strength. The considered strengthening methods were different steel jacket configurations including steel angle, channel, and plate sections. The results showed that retrofitting significantly improves blast performance of the columns. Moreover, residual strength capacity of the columns strengthened with steel channel is higher than the other models.

  4. Prediction of environmental impacts of quarry blasting operation using fuzzy logic.

    Science.gov (United States)

    Fişne, Abdullah; Kuzu, Cengiz; Hüdaverdi, Türker

    2011-03-01

    Blast-induced ground vibration is one of the most important environmental impacts of blasting operations because it may cause severe damage to structures and plants in nearby environment. Estimation of ground vibration levels induced by blasting has vital importance for restricting the environmental effects of blasting operations. Several predictor equations have been proposed by various researchers to predict ground vibration prior to blasting, but these are site specific and not generally applicable beyond the specific conditions. In this study, an attempt has been made to predict the peak particle velocity (PPV) with the help of fuzzy logic approach using parameters of distance from blast face to vibration monitoring point and charge weight per delay. The PPV and charge weight per delay were recorded for 33 blast events at various distances and used for the validation of the proposed fuzzy model. The results of the fuzzy model were also compared with the values obtained from classical regression analysis. The root mean square error estimated for fuzzy-based model was 5.31, whereas it was 11.32 for classical regression-based model. Finally, the relationship between the measured and predicted values of PPV showed that the correlation coefficient for fuzzy model (0.96) is higher than that for regression model (0.82).

  5. Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat.

    Directory of Open Access Journals (Sweden)

    Nadja Blagitko-Dorfs

    Full Text Available All-trans retinoic acid (ATRA has only limited single agent activity in AML without the PML-RARα fusion (non-M3 AML. In search of a sensitizing strategy to overcome this relative ATRA resistance, we investigated the potency of the HDAC class-I selective inhibitor entinostat in AML cell lines Kasumi-1 and HL-60 and primary AML blasts. Entinostat alone induced robust differentiation of both cell lines, which was enhanced by the combination with ATRA. This "priming" effect on ATRA-induced differentiation was at least equivalent to that achieved with the DNA hypomethylating agent decitabine, and could overall be recapitulated in primary AML blasts treated ex vivo. Moreover, entinostat treatment established the activating chromatin marks acH3, acH3K9, acH4 and H3K4me3 at the promoter of the RARβ2 gene, an essential mediator of retinoic acid (RA signaling in different solid tumor models. Similarly, RARβ2 promoter hypermethylation (which in primary blasts from 90 AML/MDS patients was surprisingly infrequent could be partially reversed by decitabine in the two cell lines. Re-induction of the epigenetically silenced RARβ2 gene was achieved only when entinostat or decitabine were given prior to ATRA treatment. Thus in this model, reactivation of RARβ2 was not necessarily required for the differentiation effect, and pharmacological RARβ2 promoter demethylation may be a bystander phenomenon rather than an essential prerequisite for the cellular effects of decitabine when combined with ATRA. In conclusion, as a "priming" agent for non-M3 AML blasts to the differentiation-inducing effects of ATRA, entinostat is at least as active as decitabine, and both act in part independently from RARβ2. Further investigation of this treatment combination in non-M3 AML patients is therefore warranted, independently of RARβ2 gene silencing by DNA methylation.

  6. Feasibility and economic analysis of solid desiccant wheel used for dehumidification and preheating in blast furnace: A case study of steel plant, Nanjing, China

    International Nuclear Information System (INIS)

    Guan, Yipeng; Zhang, Yufeng; Sheng, Ying; Kong, Xiangrui; Du, Song

    2015-01-01

    To overcome the shortcomings of huge energy consumption from conventional dehumidification using lithium bromide adsorption refrigerating (LBARD) system, a novel desiccant wheel dehumidification and preheating (DWDP) system using two-stage desiccant wheel for blast furnace is brought forward. The DWDP system was designed for dehumidification and preheating in blast furnace of steel plant. It takes waste heat in the slag flushing water as desiccant regeneration and preheating energy. To validate the feasibility of the new DWDP system, experimental studies were conducted based on a steel plant in Nanjing, China. The experiment was designed to use DWDP system in humid outdoor climates e.g. summer seasons. The experimental results indicate that the moisture removal capacity of DWDP system can reach 8.7 g/kg which will lead to the improvement of steel production by 0.9% and the coal is saved of about 2100 tons per year. With the DWDP system, the energy consumed by cooling tower of slag flushing water can decrease 7.3%. All of these energy saved equates to 10.3 million CNY annually. A comparison of initial investment and operating cost between DWDP system and LBRAD system was then carried out. The results show that the initial investment and operating cost of DWDP system is 37% and 57% of present LBARD system, and the payback period is shortened 66%. - Highlights: • A novel two-stage desiccant wheel dehumidification system for blast furnace is proposed. • Average moisture removal of 8.7 g/kg is achieved and dehumidification efficiency is 47%. • Outlet humidity ratio is less than 10 g/kg that satisfies the requirement of blast air. • Waste heat in slag flushing water is utilized and 61.4 million kJ is saved annually. • The investment and operating cost is 37% and 57% of former dehumidification system

  7. Fire and blast safety manual for fuel element manufacture

    International Nuclear Information System (INIS)

    Ensinger, U.; Koehler, B.; Mester, W.; Riotte, H.G.; Sehrbrock, H.W.

    1988-01-01

    The manual aims to enable people involved in the planning, operation, supervision, licensing or appraisal of fuel element factories to make a quick and accurate assessment of blast safety. In Part A, technical plant principles are shown, and a summary lists the flammable materials and ignition sources to be found in fuel element factories, together with theoretical details of what happens during a fire or a blast. Part B comprises a list of possible fires and explosions in fuel element factories and ways of preventing them. Typical fire and explosion scenarios are analysed more closely on the basis of experiments. Part B also contains a list and an assessment of actual fires and explosions which have occurred in fuel element factories. Part C contains safety measures to protect against fire and explosion, in-built fire safety, fire safety in plant design, explosion protection and measures to protect people from radiation and other hazards when fighting fires. A distinction is drawn between UO 2 , MOX and HTR fuel elements. (orig./DG) [de

  8. Review of methods to attenuate shock/blast waves

    Science.gov (United States)

    Igra, O.; Falcovitz, J.; Houas, L.; Jourdan, G.

    2013-04-01

    Quick and reliable shock wave attenuation is the goal of every protection facility and therefore it is not surprising that achieving this has drawn much attention during the past hundred years. Different options have been suggested; their usefulness varying from a reasonable protection to the opposite, a shock enhancement. An example for a suggestion for shock mitigation that turned out to be an enhancement of the impinging shock wave was the idea to cover a protected object with a foam layer. While the pressure behind the reflected shock wave from the foam frontal surface was smaller than that recorded in a similar reflection from a rigid wall [25], the pressure on the “protected” surface, attached to the foam's rear-surface, was significantly higher than that recorded in a similar reflection from a bare, rigid wall [11]. In protecting humans and installations from destructive shock and/or blast waves the prime goal is to reduce the wave amplitude and the rate of pressure increase across the wave front. Both measures result in reducing the wave harmful effects. During the past six decades several approaches for achieving the desired protection have been offered in the open literature. We point out in this review that while some of the suggestions offered are practical, others are impractical. In our discussion we focus on recent schemes for shock/blast wave attenuation, characterized by the availability of reliable measurements (notably pressure and optical diagnostics) as well as high-resolution numerical simulations.

  9. Gene pyramiding enhances durable blast disease resistance in rice.

    Science.gov (United States)

    Fukuoka, Shuichi; Saka, Norikuni; Mizukami, Yuko; Koga, Hironori; Yamanouchi, Utako; Yoshioka, Yosuke; Hayashi, Nagao; Ebana, Kaworu; Mizobuchi, Ritsuko; Yano, Masahiro

    2015-01-14

    Effective control of blast, a devastating fungal disease of rice, would increase and stabilize worldwide food production. Resistance mediated by quantitative trait loci (QTLs), which usually have smaller individual effects than R-genes but confer broad-spectrum or non-race-specific resistance, is a promising alternative to less durable race-specific resistance for crop improvement, yet evidence that validates the impact of QTL combinations (pyramids) on the durability of plant disease resistance has been lacking. Here, we developed near-isogenic experimental lines representing all possible combinations of four QTL alleles from a durably resistant cultivar. These lines enabled us to evaluate the QTLs singly and in combination in a homogeneous genetic background. We present evidence that pyramiding QTL alleles, each controlling a different response to M. oryzae, confers strong, non-race-specific, environmentally stable resistance to blast disease. Our results suggest that this robust defence system provides durable resistance, thus avoiding an evolutionary "arms race" between a crop and its pathogen.

  10. A case study of blast eye injury at work place

    Directory of Open Access Journals (Sweden)

    Prabhakar Srinivasapuram Krishnacharya

    2013-12-01

    Full Text Available This case report aims at investigating whether two consecutive surgical settings would be beneficial in achieving postoperative success for the patient with blast eye injury. A 45-year-old male patient admitted on 17 th October 2011 with history of blast eye injury. Right eye examination revealed central corneal laceration with incarceration of lens matter, multiple foreign bodies also seen embedded in the eyelid margins and in the left cornea. Computed ocular tomography showed a retained intraocular foreign body (IOFB in the right eye. Simultaneous corneal laceration repair and extraction of the ruptured lens performed as primary procedure under general anesthesia. Intraoperative posterior capsule loss was noticed with vitreous presentation. Anterior vitrectomy with removal of the IOFB was done. Foreign bodies were also removed from the left cornea. Penetrating keratoplasty (PK with scleral fixated intraocular lens implantation executed 4 months later as secondary procedure. Visual acuity maintained at 6/24 in 2 years follow-up. In conclusion, two consecutive surgical settings has the advantage of calculating the intra ocular lens power.

  11. The bone marrow microenvironment - Home of the leukemic blasts.

    Science.gov (United States)

    Shafat, Manar S; Gnaneswaran, Bruno; Bowles, Kristian M; Rushworth, Stuart A

    2017-09-01

    Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM). Ex-vivo AML exhibits a high level of spontaneous apoptosis. Furthermore, relapse for patients achieving remission occurs from minimal residual disease harboured within the BM microenvironment. Taken together, these observations illustrate the importance of the BM microenvironment in sustaining AML. While significant progress has been made elaborating the small-scale genetic mutations and larger-scale chromosomal translocations that contribute to the development of AML and its prognosis in response to treatment, less is understood about the complex microenvironment of the BM, which is known to be a key player in the pathogenesis of the disease. As we look towards future therapies, the consideration that the BM microenvironment is uniquely important as a niche for AML - coupled with the idea that leukaemic blasts are more likely to be genetically unstable and therefore evolve resistance to conventional chemotherapies - make the functions of the non-malignant cells of the BM attractive targets for therapy. In this review, we discuss the microanatomy of the BM and provide an overview of the evidence supporting the role of the BM microenvironment in creating conditions conducive to the survival and proliferation of AML blasts. Ultimately, we examine the therapeutic potential of uncoupling AML from the BM microenvironment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. A Secure Web Application Providing Public Access to High-Performance Data Intensive Scientific Resources - ScalaBLAST Web Application

    International Nuclear Information System (INIS)

    Curtis, Darren S.; Peterson, Elena S.; Oehmen, Chris S.

    2008-01-01

    This work presents the ScalaBLAST Web Application (SWA), a web based application implemented using the PHP script language, MySQL DBMS, and Apache web server under a GNU/Linux platform. SWA is an application built as part of the Data Intensive Computer for Complex Biological Systems (DICCBS) project at the Pacific Northwest National Laboratory (PNNL). SWA delivers accelerated throughput of bioinformatics analysis via high-performance computing through a convenient, easy-to-use web interface. This approach greatly enhances emerging fields of study in biology such as ontology-based homology, and multiple whole genome comparisons which, in the absence of a tool like SWA, require a heroic effort to overcome the computational bottleneck associated with genome analysis. The current version of SWA includes a user account management system, a web based user interface, and a backend process that generates the files necessary for the Internet scientific community to submit a ScalaBLAST parallel processing job on a dedicated cluster

  13. Risk management of energy efficiency projects in the industry - sample plant for injecting pulverized coal into the blast furnaces

    Directory of Open Access Journals (Sweden)

    Jovanović Filip P.

    2016-01-01

    Full Text Available This paper analyses the applicability of well-known risk management methodologies in energy efficiency projects in the industry. The possibilities of application of the selected risk management methodology are demonstrated within the project of the plants for injecting pulverized coal into blast furnaces nos. 1 and 2, implemented by the company US STEEL SERBIA d.o.o. in Smederevo. The aim of the project was to increase energy efficiency through the reduction of the quantity of coke, whose production requires large amounts of energy, reduction of harmful exhaust emission and increase productivity of blast furnaces through the reduction of production costs. The project was complex and had high costs, so that it was necessary to predict risk events and plan responses to identified risks at an early stage of implementation, in the course of the project design, in order to minimise losses and implement the project in accordance with the defined time and cost limitations. [Projekat Ministarstva nauke Republike Srbije, br. 179081: Researching contemporary tendencies of strategic management using specialized management disciplines in function of competitiveness of Serbian economy

  14. Influence of blast furnace gas flow speed on dust deposition characteristics in butterfly valve region

    Directory of Open Access Journals (Sweden)

    Lixin WANG

    2016-02-01

    Full Text Available The blast furnace gas contains plenty of dust, which deposits easily on the bottom of seat sealing surface of the tri-eccentric butterfly valve in the pipeline, causing stuck and damage to the valve plate, thereby affects the production of the blast furnace and brings great economic loss. To derive the influence mechanism of effects of the blast furnace gas flow speed within the pipeline on the dust deposition laws in the butterfly valve region, a 3D model of the butterfly valve and its regional flow field is built with Pro/E software. Based on FLUENT module of ANSYS Workbench, along with standard k-ε turbulence model and DPM model, simulation analysis of moving trajectories of dust particles in butterfly valve region under 3 blast furnace gas flow speeds is conducted. Results show that the deposition mass of dust particles decreases firstly, then increases with the enlargement of valve plate opening angle under the blast furnace gas flow speed of 8 m/s, while decreases with the enlargement of valve plate opening under the blast furnace gas flow speeds of 12 m/s and 16 m/s. In the case of the valve plate opening angle of 15°, the deposition rate of dust particles increases with the growing of blast furnace gas flow speed, while decreases with the growing of blast furnace gas flow speed under the cases of valve plate opening angle of 45° and 75°. The research results provide a theoretical reference for the development of automatic dust removal system in the butterfly valve region of the blast furnace gas pipeline.

  15. Blast Shock Wave Mitigation Using the Hydraulic Energy Redirection and Release Technology

    Science.gov (United States)

    Chen, Yun; Huang, Wei; Constantini, Shlomi

    2012-01-01

    A hydraulic energy redirection and release technology has been developed for mitigating the effects of blast shock waves on protected objects. The technology employs a liquid-filled plastic tubing as a blast overpressure transformer to transfer kinetic energy of blast shock waves into hydraulic energy in the plastic tubings. The hydraulic energy is redirected through the plastic tubings to the openings at the lower ends, and then is quickly released with the liquid flowing out through the openings. The samples of the specifically designed body armor in which the liquid-filled plastic tubings were installed vertically as the outer layer of the body armor were tested. The blast test results demonstrated that blast overpressure behind the body armor samples was remarkably reduced by 97% in 0.2 msec after the liquid flowed out of its appropriate volume through the openings. The results also suggested that a volumetric liquid surge might be created when kinetic energy of blast shock wave was transferred into hydraulic energy to cause a rapid physical movement or displacement of the liquid. The volumetric liquid surge has a strong destructive power, and can cause a noncontact, remote injury in humans (such as blast-induced traumatic brain injury and post-traumatic stress disorder) if it is created in cardiovascular system. The hydraulic energy redirection and release technology can successfully mitigate blast shock waves from the outer surface of the body armor. It should be further explored as an innovative approach to effectively protect against blast threats to civilian and military personnel. PMID:22745740

  16. Blast shock wave mitigation using the hydraulic energy redirection and release technology.

    Directory of Open Access Journals (Sweden)

    Yun Chen

    Full Text Available A hydraulic energy redirection and release technology has been developed for mitigating the effects of blast shock waves on protected objects. The technology employs a liquid-filled plastic tubing as a blast overpressure transformer to transfer kinetic energy of blast shock waves into hydraulic energy in the plastic tubings. The hydraulic energy is redirected through the plastic tubings to the openings at the lower ends, and then is quickly released with the liquid flowing out through the openings. The samples of the specifically designed body armor in which the liquid-filled plastic tubings were installed vertically as the outer layer of the body armor were tested. The blast test results demonstrated that blast overpressure behind the body armor samples was remarkably reduced by 97% in 0.2 msec after the liquid flowed out of its appropriate volume through the openings. The results also suggested that a volumetric liquid surge might be created when kinetic energy of blast shock wave was transferred into hydraulic energy to cause a rapid physical movement or displacement of the liquid. The volumetric liquid surge has a strong destructive power, and can cause a noncontact, remote injury in humans (such as blast-induced traumatic brain injury and post-traumatic stress disorder if it is created in cardiovascular system. The hydraulic energy redirection and release technology can successfully mitigate blast shock waves from the outer surface of the body armor. It should be further explored as an innovative approach to effectively protect against blast threats to civilian and military personnel.

  17. Blast shock wave mitigation using the hydraulic energy redirection and release technology.

    Science.gov (United States)

    Chen, Yun; Huang, Wei; Constantini, Shlomi

    2012-01-01

    A hydraulic energy redirection and release technology has been developed for mitigating the effects of blast shock waves on protected objects. The technology employs a liquid-filled plastic tubing as a blast overpressure transformer to transfer kinetic energy of blast shock waves into hydraulic energy in the plastic tubings. The hydraulic energy is redirected through the plastic tubings to the openings at the lower ends, and then is quickly released with the liquid flowing out through the openings. The samples of the specifically designed body armor in which the liquid-filled plastic tubings were installed vertically as the outer layer of the body armor were tested. The blast test results demonstrated that blast overpressure behind the body armor samples was remarkably reduced by 97% in 0.2 msec after the liquid flowed out of its appropriate volume through the openings. The results also suggested that a volumetric liquid surge might be created when kinetic energy of blast shock wave was transferred into hydraulic energy to cause a rapid physical movement or displacement of the liquid. The volumetric liquid surge has a strong destructive power, and can cause a noncontact, remote injury in humans (such as blast-induced traumatic brain injury and post-traumatic stress disorder) if it is created in cardiovascular system. The hydraulic energy redirection and release technology can successfully mitigate blast shock waves from the outer surface of the body armor. It should be further explored as an innovative approach to effectively protect against blast threats to civilian and military personnel.

  18. Blast from the Past Gives Clues About Early Universe

    Science.gov (United States)

    2009-10-01

    Astronomers using the National Science Foundation's Very Large Array (VLA) radio telescope have gained tantalizing insights into the nature of the most distant object ever observed in the Universe -- a gigantic stellar explosion known as a Gamma Ray Burst (GRB). The explosion was detected on April 23 by NASA's Swift satellite, and scientists soon realized that it was more than 13 billion light-years from Earth. It represents an event that occurred 630 million years after the Big Bang, when the Universe was only four percent of its current age of 13.7 billion years. This explosion provides an unprecedented look at an era when the Universe was very young and also was undergoing drastic changes. The primal cosmic darkness was being pierced by the light of the first stars and the first galaxies were beginning to form. The star that exploded in this event was a member of one of these earliest generations of stars," said Dale Frail of the National Radio Astronomy Observatory. Astronomers turned telescopes from around the world to study the blast, dubbed GRB 090423. The VLA first looked for the object the day after the discovery, detected the first radio waves from the blast a week later, then recorded changes in the object until it faded from view more than two months later. "It's important to study these explosions with many kinds of telescopes. Our research team combined data from the VLA with data from X-ray and infrared telescopes to piece together some of the physical conditions of the blast," said Derek Fox of Pennsylvania State University. "The result is a unique look into the very early Universe that we couldn't have gotten any other way," he added. The scientists concluded that the explosion was more energetic than most GRBs, was a nearly-spherical blast, and that it expanded into a tenuous and relatively uniform gaseous medium surrounding the star. Astronomers suspect that the very first stars in the Universe were very different -- brighter, hotter, and more

  19. Quality Space and Launch Requirements Addendum to AS9100C

    Science.gov (United States)

    2015-03-05

    inability to repair vehicles on orbit, stringent quality and reliability requirements are levied on contractors to ensure that products will meet their...standard either in full or as appropriately tailored shall be levied on prime contractors, subcontractors, and their sub-tier suppliers of space and...laurence.s.jpatzman@lmco.c om Bryant Allen HQ U.S. Army Material Command, Departmental Standardization Officer bryant.allen1@us.army.mil Aileen Sedmark ASD(R&E)/SE

  20. Smoothwall blasting planned for the underground research facility at Yucca Mountain

    International Nuclear Information System (INIS)

    Bullock, R.L.; McKenzie, J.

    1990-01-01

    This paper discusses whether or not the Exploratory Shaft Facility (ESF) at yucca Mountain, Nevada will be completely mechanically excavated, completely developed by drilling and blasting or whether both methods will be utilized on different parts of the ESF. Where drilling and blasting may be used, smoothwall blasting techniques will be used and strict controls will be placed on drill hole placement and alignment, and the correct use of limiting damage explosive, so that minimum amount of fracturing will occur beyond the perimeter of the openings. The authors discuss why this is necessary and how it is achievable

  1. Proceedings of the twenty-fourth annual conference on explosives and blasting technique

    Energy Technology Data Exchange (ETDEWEB)

    1998-01-01

    Papers of interest to the coal industry include: death of a coal shovel; deep hole blasting with SMS (site-mix slurry system); trend of bulk explosives in India; bottomhole annular pressure - a theoretical problem with real effects; maximizing rotary blast hole drills; explosive energy concept for drill productivity and higher overall productivity at reduced excavation costs; large diameter presplitting improved through two novel techniques; avoiding tragedy - lessons to be learned from a flyrock fatality; and an economic analysis of cast blasting compared to other stripping alternatives.

  2. Camouflet blasting in water. The role of damping additives in the formation process of a cavity

    Energy Technology Data Exchange (ETDEWEB)

    Batalov, V.A.; Kotov, V.A.; Orekin, U.K.; Panov, N.V.; Telegin, G.F.; Trunin, R.F.

    1980-01-01

    Results are given from an X-ray analysis of the formation of a camouflet cavity in water during blasting using chemical explosives. Variations on combined blasting are examined together with variations for blasting schemes when layers made from less dense materials-water and polystyrene foam (is approximately equal to .5 grams per cubic centimeter)-are placed between the explosive charges and the water. It is demonstrated that the calculation model of the medium choosen describes with sufficient accuracy the entire aggragate of experimental data.

  3. Study of TATP: blast characteristics and TNT equivalency of small charges

    Science.gov (United States)

    Pachman, J.; Matyáš, R.; Künzel, M.

    2014-07-01

    Blast wave parameters including incident overpressure, impulse and duration of the positive phase of the incident blast wave and its time of arrival were experimentally determined for 50 g charges of low bulk density () dry TATP (3,3,6,6,9,9-hexamethyl-1,2,4,5,7,8-hexoxonane). The results were compared with published TNT data, and TNT equivalencies were determined, resulting in the values of 70 % based on overpressure and 55 % based on impulse of the positive phase of the blast wave. Brisance by the Hess method (lead cylinder compression) was found to be about one-third of that for TNT (at density . Detonation velocities averaged around

  4. Peroxisomal alanine: glyoxylate aminotransferase AGT1 is indispensable for appressorium function of the rice blast pathogen, Magnaporthe oryzae.

    Directory of Open Access Journals (Sweden)

    Vijai Bhadauria

    Full Text Available The role of β-oxidation and the glyoxylate cycle in fungal pathogenesis is well documented. However, an ambiguity still remains over their interaction in peroxisomes to facilitate fungal pathogenicity and virulence. In this report, we characterize a gene encoding an alanine, glyoxylate aminotransferase 1 (AGT1 in Magnaporthe oryzae, the causative agent of rice blast disease, and demonstrate that AGT1 is required for pathogenicity of M. oryzae. Targeted deletion of AGT1 resulted in the failure of penetration via appressoria; therefore, mutants lacking the gene were unable to induce blast symptoms on the hosts rice and barley. This penetration failure may be associated with a disruption in lipid mobilization during conidial germination as turgor generation in the appressorium requires mobilization of lipid reserves from the conidium. Analysis of enhanced green fluorescent protein expression using the transcriptional and translational fusion with the AGT1 promoter and open reading frame, respectively, revealed that AGT1 expressed constitutively in all in vitro grown cell types and during in planta colonization, and localized in peroxisomes. Peroxisomal localization was further confirmed by colocalization with red fluorescent protein fused with the peroxisomal targeting signal 1. Surprisingly, conidia produced by the Δagt1 mutant were unable to form appressoria on artificial inductive surfaces, even after prolonged incubation. When supplemented with nicotinamide adenine dinucleotide (NAD(++pyruvate, appressorium formation was restored on an artificial inductive surface. Taken together, our data indicate that AGT1-dependent pyruvate formation by transferring an amino group of alanine to glyoxylate, an intermediate of the glyoxylate cycle is required for lipid mobilization and utilization. This pyruvate can be converted to non-fermentable carbon sources, which may require reoxidation of NADH generated by the β-oxidation of fatty acids to NAD(+ in

  5. Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury.

    Science.gov (United States)

    Huber, Bertrand R; Meabon, James S; Martin, Tobin J; Mourad, Pierre D; Bennett, Raymond; Kraemer, Brian C; Cernak, Ibolja; Petrie, Eric C; Emery, Michael J; Swenson, Erik R; Mayer, Cynthia; Mehic, Edin; Peskind, Elaine R; Cook, David G

    2013-01-01

    Mild traumatic brain injury (mTBI) is considered the 'signature injury' of combat veterans that have served during the wars in Iraq and Afghanistan. This prevalence of mTBI is due in part to the common exposure to high explosive blasts in combat zones. In addition to the threats of blunt impact trauma caused by flying objects and the head itself being propelled against objects, the primary blast overpressure (BOP) generated by high explosives is capable of injuring the brain. Compared to other means of causing TBI, the pathophysiology of mild-to-moderate BOP is less well understood. To study the consequences of BOP exposure in mice, we employed a well-established approach using a compressed gas-driven shock tube that recapitulates battlefield-relevant open-field BOP. We found that 24 hours post-blast a single mild BOP provoked elevation of multiple phospho- and cleaved-tau species in neurons, as well as elevating manganese superoxide-dismutase (MnSOD or SOD2) levels, a cellular response to oxidative stress. In hippocampus, aberrant tau species persisted for at least 30 days post-exposure, while SOD2 levels returned to sham control levels. These findings suggest that elevated phospho- and cleaved-tau species may be among the initiating pathologic processes induced by mild blast exposure. These findings may have important implications for efforts to prevent blast-induced insults to the brain from progressing into long-term neurodegenerative disease processes.

  6. Polyubiquitin is required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.

    Science.gov (United States)

    Oh, Yeonyee; Franck, William L; Han, Sang-Oh; Shows, Angela; Gokce, Emine; Muddiman, David C; Dean, Ralph A

    2012-01-01

    Protein ubiquitination, which is highly selective, regulates many important biological processes including cellular differentiation and pathogenesis in eukaryotic cells. Here, we integrated pharmacological, molecular and proteomic approaches to explore the role of ubiquitination in Magnaporthe oryzae, the leading fungal disease of rice world-wide. Inhibition of ubiquitin-mediated proteolysis using the 26S proteasome inhibitor, Bortezomib, significantly attenuated conidia germination, appressorium formation and pathogenicity in M. oryzae. Gene expression analysis revealed that many genes associated with protein ubiquitination were developmentally regulated during conidia germination. Only a few, including a polyubiquitin encoding gene, MGG_01282, were more abundantly expressed during appressorium formation and under nitrogen starvation. Targeted gene deletion of MGG_01282, in addition to a significant reduction in protein ubiquitination as determined by immuno blot assays, resulted in pleiotropic effects on M. oryzae including reduced growth and sporulation, abnormal conidia morphology, reduced germination and appressorium formation, and the inability to cause disease. Mutants were also defective in sexual development and were female sterile. Using mass spectrometry, we identified 63 candidate polyubiquitinated proteins under nitrogen starvation, which included overrepresentation of proteins involved in translation, transport and protein modification. Our study suggests that ubiquitination of target proteins plays an important role in nutrient assimilation, development and pathogenicity of M. oryzae.

  7. RESEARCH AND MODEL DEVELOPMENT OF DRILLING AND BLASTING TECHNOLOGY PENETRATIONS OF VERTICAL SHAFTS

    Directory of Open Access Journals (Sweden)

    O. I. Rubleva

    2007-10-01

    Full Text Available The model of destruction of rocks by explosion in vertical shafts is presented. On its basis the most important parameters of technical-and-economical indices of the drilling-and-blasting technology are calculated.

  8. Full scale numerical analysis of high performance concrete columns designed to withstand severe blast impact

    DEFF Research Database (Denmark)

    Riisgaard, Benjamin; Georgakis, Christos; Stang, Henrik

    2007-01-01

    Polymer reinforced Compact Reinforced Composite, PCRC, is a Fiber reinforced Densified Small Particle system, FDSP, combined with a high strength longitudinal flexural rebar arrangement laced together with polymer lacing to avoid shock initiated disintegration of the structural element under blast...

  9. A PC-Based Tool for Coupled CFD and CSD Simulation of Blast-Barrier Responses

    National Research Council Canada - National Science Library

    Chen, Zen; Bewick, Bryan; Salim, Hani A; Kiger, Sam A; Dinan, Robert J; Hu, Wenquin

    2006-01-01

    ... for predicting the responses of a blast barrier. An axisymmetrical model is formulated using a coupled CFD and CSD simulation procedure designed via the Material Point Method in spatial discretization...

  10. An alternative method for the measurement of the mechanical impulse of a vertically directed blast

    CSIR Research Space (South Africa)

    Turner, GR

    2008-01-01

    Full Text Available An alternative method for the measurement of the total mechanical impulse of a vertically directed blast due to an explosive charge is presented. The method differs from apparatus that employ a vertically displaced mass (similar in principle...

  11. A numerical model for blast injury of human thorax based on digitized visible human.

    Science.gov (United States)

    Li, Xiao-Fang; Kuang, Jiang-Ming; Nie, Si-Bing; Xu, Jing; Zhu, Jin; Liu, Yi-He

    2017-12-04

    Knowledge of the pressure distribution around human thorax in blast help to understand the injury mechanisms and their assessment. To investigate the transmission mechanism of the pressure on human thorax in blast, a three dimension surface model of human thorax was constructed in this work. To increase the precious of this model, tetrahedron element division method was applied to transfer the rough 3D surface model to hexahedral elements model. Using this model, the high pressure duration was computationally solved using numerical simulation of the hexahedral elements. Simulation results showed that the apex of lungs was subjected to the largest stress in a blast. In order to verify this result, an animal experiment was performed on a dog. The animal experimental results was shown to have a same variation tendency with the calculation results based on our numerical model of human thorax, which made this model reliable for the blast injury research.

  12. Novel method to dynamically load cells in 3D-hydrogels culture for blast injury studies

    Science.gov (United States)

    Sory, David R.; Areias, Anabela C.; Overby, Darryl R.; Proud, William G.

    2017-01-01

    For at least a century explosive devices have been one of the most important causes of injuries in military conflicts as well as in terrorist attacks. Although significant experimental and modelling efforts have been focussed on blast injuries at the organ or tissue level, few studies have investigated the mechanisms of blast injuries at the cellular level. This paper introduces an in vitro method compatible with living cells to examine the effects of high stress and short-duration pulses relevant to blast loadings and blunt trauma. The experimental phase involves high strain-rate axial compression of cylindrical specimens within an hermetically sealed chamber made of biocompatible polymer. Numerical simulations were performed in order to verify the experimental loading conditions and to characterize the loading path within the sample. A proof of concept is presented so as to establish a new window to address fundamental questions regarding blast injury at the cellular level.

  13. The Mechanism and Application of Deep-Hole Precracking Blasting on Rockburst Prevention

    Directory of Open Access Journals (Sweden)

    Zhenhua Ouyang

    2015-01-01

    Full Text Available The mechanism of preventing rockburst through deep-hole precracking blasting was studied based on experimental test, numerical simulation, and field testing. The study results indicate that the deep-hole precracking could change the bursting proneness and stress state of coal-rock mass, thereby preventing the occurrence of rockburst. The bursting proneness of the whole composite structure could be weakened by the deep-hole precracking blasting. The change of stress state in the process of precracking blasting is achieved in two ways: (1 artificially break the roof apart, thus weakening the continuity of the roof strata, effectively inducing the roof caving while reducing its impact strength; and (2 the dynamic shattering and air pressure generated by the blasting can structurally change the properties of the coal-rock mass by mitigating the high stress generation and high elastic energy accumulation, thus breaking the conditions of energy transfer and rock burst occurrence.

  14. Hot metal temperature prediction and simulation by fuzzy logic in a blast furnace

    International Nuclear Information System (INIS)

    Romero, M. A.; Jimenez, J.; Mochon, J.; Formoso, A.; Bueno, F.; Menendez, J. L.

    2000-01-01

    This work describes the development and further validation of a model devoted to blast furnace hot metal temperature forecast, based on Fuzzy logic principles. The model employs as input variables, the control variables of an actual blast furnace: Blast volume, moisture, coal injection, oxygen addition, etc. and it yields as a result the hot metal temperature with a forecast horizon of forty minutes. As far as the variables used to develop the model have been obtained from data supplied by an actual blast furnaces sensors, it is necessary to properly analyse and handle such data. Especial attention was paid to data temporal correlation, fitting by interpolation the different sampling rates. In the training stage of the model the ANFIS (Adaptive Neuro-Fuzzy Inference System) and the Subtractive Clustering algorithms have been used. (Author) 9 refs

  15. Measurements of seismic vibrations induced by Quarry blasts at the Mostecká basin

    Czech Academy of Sciences Publication Activity Database

    Kaláb, Zdeněk

    -, č. 271 (2006), s. 49-58 ISSN 0372-9508 Institutional research plan: CEZ:AV0Z30860518 Keywords : seismic vibration * slope stability * quarry blast Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  16. Blasting methods for heterogeneous rocks in hillside open-pit mines with high and steep slopes

    Science.gov (United States)

    Chen, Y. J.; Chang, Z. G.; Chao, X. H.; Zhao, J. F.

    2017-06-01

    In the arid desert areas in Xinjiang, most limestone quarries are hillside open-pit mines (OPMs) where the limestone is hard, heterogeneous, and fractured, and can be easily broken into large blocks by blasting. This study tried to find effective technical methods for blasting heterogeneous rocks in such quarries based on an investigation into existing problems encountered in actual mining at Hongshun Limestone Quarry in Xinjiang. This study provided blasting schemes for hillside OPMs with different heights and slopes. These schemes involve the use of vertical deep holes, oblique shallow holes, and downslope hole-by-hole sublevel or simultaneous detonation techniques. In each bench, the detonations of holes in a detonation unit occur at intervals of 25-50 milliseconds. The research findings can offer technical guidance on how to blast heterogeneous rocks in hillside limestone quarries.

  17. Genetic diversity for sustainable rice blast management in China: adoption and impact

    NARCIS (Netherlands)

    Revilla-Molina, I.M.

    2009-01-01

    Keywords: Disease management, genetic diversity, rice interplanting, competition, resource complementarity, technical efficiency, production function, Magnaporthe grisea

    The experience on rice blast in Yunnan Province, China, is one of the most successful and widely publicized examples

  18. Manual for the prediction of blast and fragment loadings on structures

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    The purpose of this manual is to provide Architect-Engineer (AE) firms guidance for the prediction of air blast, ground shock and fragment loadings on structures as a result of accidental explosions in or near these structures. Information in this manual is the result of an extensive literature survey and data gathering effort, supplemented by some original analytical studies on various aspects of blast phenomena. Many prediction equations and graphs are presented, accompanied by numerous example problems illustrating their use. The manual is complementary to existing structural design manuals and is intended to reflect the current state-of-the-art in prediction of blast and fragment loads for accidental explosions of high explosives at the Pantex Plant. In some instances, particularly for explosions within blast-resistant structures of complex geometry, rational estimation of these loads is beyond the current state-of-the-art.

  19. Assessment of Mechanical Damage to Odontocete Respiratory Tract Tissues After Controlled Exposure to Blasting

    National Research Council Canada - National Science Library

    Reidenberg, Joy

    2004-01-01

    The odontocete respiratory tract is adapted to withstand the gradual pressure changes associated with diving, yet nothing is known about how it responds to the sudden pressure changes of a blast exposure...

  20. Development of Mine Blast Protected Vehicle Structures for Future Combat Systems

    National Research Council Canada - National Science Library

    Skaggs, Reed; Cheeseman, Bryan; Yen, Chian-Fong; Dooley, Robert; Boyd, Kevin; Walsh, Shawn; Campbell, Jim; Hoppel, Chris; Goetz, Richard

    2004-01-01

    ... blast underneath its structure. By developing structural and applique technologies, along with decoupled/shock-limiting restraint systems for the crew, the impulsive forces can be managed for crew survivability...