WorldWideScience

Sample records for straight sections hits

  1. Production of short straight sections hits 100 units

    CERN Multimedia

    2005-01-01

    The 100th short straight section for the Large Hadron Collider was assembled at CERN at the beginning of April. These units combine superconducting quadrupoles and other multipole corrector magnets, housed in their cryostats, which are used to guide, focus and fine-tune the beam in the LHC. Building 904, where the 474 short straight sections are being assembled, is often called "Lego Land" by the workers, with a touch of humor and pride because of the wide variety of these sets of magnets and cryostats .

  2. Assembling the LHC short straight sections

    CERN Document Server

    Maximilien Brice

    2005-01-01

    The building where the short straight sections are being assembled, was often called ‘Lego Land’ by the workers because of the wide variety of sets of magnets and cryostats. Short straight sections contain magnets for manipulating the beam inside cryostats with liquid helium to keep the magnets at a cool 1.9 K (-271.3°C).

  3. SPS, preassembly of short straight sections

    CERN Multimedia

    1975-01-01

    Short straight sections were preassembled with their vacuum chambers, ready for installation in the SPS. Here we see two, containing sextupoles for chromaticity adjustment. See also 7501017, 7501018, and Annual Report 1976, p.174.

  4. SPS, short straight section with sextupole

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    Short straight sections were preassembled with their vacuum chambers, ready for installation in the SPS. This one contains a sextupole for chromaticity adjustment. See also 7501017, 7501009X, and Annual Report 1974, p.174.

  5. Beam line from straight-section 16

    CERN Multimedia

    CERN PhotoLab

    1971-01-01

    The start of a long trail. The beam line from straight-section 16, where protons are fast ejected, is seen at the point where it crosses the Linac shielding wall as it leaves the PS en route to the ISR.

  6. New airfoil sections for straight bladed turbine

    Science.gov (United States)

    Boumaza, B.

    1987-07-01

    A theoretical investigation of aerodynamic performance for vertical axis Darrieus wind turbine with new airfoils sections is carried out. The blade section aerodynamics characteristics are determined from turbomachines cascade model. The model is also adapted to the vertical Darrieus turbine for the performance prediction of the machine. In order to choose appropriate value of zero-lift-drag coefficient in calculation, an analytical expression is introduced as function of chord-radius ratio and Reynolds numbers. New airfoils sections are proposed and analyzed for straight-bladed turbine.

  7. New airfoil sections for straight bladed turbine

    International Nuclear Information System (INIS)

    Boumaza, B.

    1987-07-01

    A theoretical investigation of aerodynamic performance for vertical axis Darrieus wind turbine with new airfoils sections is carried out. The blade section aerodynamics characteristics are determined from turbomachines cascade model. The model is also adapted to the vertical Darrieus turbine for the performance prediction of the machine. In order to choose appropriate value of zero-lift-drag coefficient in calculation, an analytical expression is introduced as function of chord-radius ratio and Reynolds numbers. New airfoils sections are proposed and analyzed for straight-bladed turbine

  8. The short straight sections for the LHC

    International Nuclear Information System (INIS)

    Bergot, J.B.; Coussy, E.; Dambre, P.; Ollivier, Y.; Reynet, D.; Vincent, D.; Rohmig, P.

    1999-01-01

    In 1995 a close collaboration between CERN, CEA and CNRS has been established for the design, proto-typing and follow-up of industrial series production of a sub-assembly of the Large Hadron Collider (LHC). In this frame, the design office of IPN's Accelerator R and D group has in charge one of these contracts concerning the 386 Short Straight Sections (SSS) and particularly: - the cryostat design; - the study of procedures and tool assembly; - the construction of two prototypes during the year 1999; - the industrialization and the production follow-up for the series SSS. This collaboration will last until the year 2004. (authors)

  9. Commissioning of the cryogenics of the LHC long straight sections

    International Nuclear Information System (INIS)

    Perin, A.; Casas-Cubillos, J.; Claudet, S.; Darve, C.; Ferlin, G.; Millet, F.; Parente, C.; Rabehl, R.; Soubiran, M.; van Weelderen, R.; Wagner, U.

    2010-01-01

    The LHC is made of eight circular arcs interspaced with eight Long Straight Sections (LSS). Most powering interfaces to the LHC are located in these sections where the particle beams are focused and shaped for collision, cleaning and acceleration. The LSSs are constituted of several unique cryogenic devices and systems like electrical feed-boxes, standalone superconducting magnets, superconducting links, RF cavities and final focusing superconducting magnets. This paper presents the cryogenic commissioning and the main results obtained during the first operation of the LHC Long Straight Sections.

  10. Commissioning of the Cryogenics of the LHC Long Straight Sections

    CERN Document Server

    Perin, A; Claudet, S; Darve, C; Ferlin, G; Millet, F; Parente, C; Rabehl, R; Soubiran, M; van Weelderen, R; Wagner, U

    2010-01-01

    The LHC is made of eight circular arcs interspaced with eight Long Straight Sections (LSS). Most powering interfaces to the LHC are located in these sections where the particle beams are focused and shaped for collision, cleaning and acceleration. The LSSs are constituted of several unique cryogenic devices and systems like electrical feed-boxes, standalone superconducting magnets, superconducting links, RF cavities and final focusing superconducting magnets. This paper presents the cryogenic commissioning and the main results obtained during the first operation of the LHC Long Straight Sections.

  11. The DFBX cryogenic distribution boxes for the LHC straight sections

    International Nuclear Information System (INIS)

    Zbasnik, Jon P.; Corradi, Carol A.; Green, Michael A.; Kajiyama, Y.; Knolls, Michael J.; LaMantia, Roberto F.; Rasson, Joseph E.; Reavill, Dulie; Turner, William C.

    2002-01-01

    The DFBX distribution boxes are designed to connect the LHC cryogenic distribution system to the interaction region quadrupoles [1] and dipoles for the Large Hadron Collider (LHC). The DFBX distribution boxes also have the current leads for the superconducting interaction region magnets and the LHC interaction region correction coils. The DFBX boxes also connect the magnet and cryogenic instrumentation to the CERN data collection system. The DFBX boxes serve as the cryogenic circulation center and the nerve center for four of the LHC straight sections. This report describes primarily the cryogenic function of the DFBXs

  12. UHV testing of spare straight section chambers of Indus-2

    International Nuclear Information System (INIS)

    Tiwari, S.K.; Ratnakala, K.C.; Sridhar, R.; Bhange, N.J.; Netram; Shukla, S.K.

    2015-01-01

    The vacuum system of Synchrotron Radiation Source, Indus-2, in RRCAT has been functioning up to the mark, continuously for last 10 years. To continue the same trouble-free functioning, it was planned to procure spares for all critical vacuum components, test for UHV performance and keep ready for installation, in case of requirement. As a part of this planning, fifteen chambers made of Aluminium alloy (6063 T6), procured as spare straight section chambers for Indus-2, and were tested for UHV performance. They were tested in batches of 2 or 3 chambers, depending upon their length, and the similar testing-procedure was followed. This paper narrates the tests carried out, and the results obtained. Ultimate vacuum in the range (2 to 9) x 10 -10 mbar was achieved. (author)

  13. Structural damping results from vibration tests of straight piping sections

    International Nuclear Information System (INIS)

    Ware, A.G.; Thinnes, G.L.

    1984-01-01

    EG and G Idaho is assisting the USNRC and the Pressure Vessel Research Committee in supporting a final position on revised damping values for structural analyses of nuclear piping systems. As part of this program, a series of vibrational tests on 76-mm and 203-mm (3-in. amd 8-in.) Schedule 40 carbon steel piping was conducted to determine the changes in structural damping due to various parametric effects. The 10-m (33-ft) straight sections of piping were rigidly supported at the ends. Spring, rod, and constant force hangers, as well as a sway brace and snubbers were included as intermediate supports. Excitation was provided by low-force level hammer inpacts, a hydraulic shaker, and a 445-kN (50-ton) overhead crane. Data was recorded using acceleration, strain, and displacement time histories. This paper presents results from the testing showing the effect of stress level and type of supports on structural damping in piping

  14. Thermal Performance of the LHC Short Straight Section Cryostat

    CERN Document Server

    Bergot, J B; Nielsen, L; Parma, Vittorio; Rohmig, P; Roy, E

    2002-01-01

    The LHC Short Straight Section (SSS) cryostat houses and thermally protects in vacuum the cold mass which contains a twin-aperture superconducting quadrupole magnet and superconducting corrector magnets operating at 1.9 K in superfluid helium. In addition to mechanical requirements, the cryostat is designed to minimize the heat in-leak from the ambient temperature to the cold mass. Mechanical components linking the cold mass to the vacuum vessel such as support posts and an insulation vacuum barrier are designed to have minimum heat conductivity with efficient thermalisations for heat interception. Heat in-leak by radiation is reduced by employing multilayer insulation wrapped around the cold mass and an actively cooled aluminium thermal shield. The recent commissioning and operation of two SSS prototypes in the LHC Test String 2 have given a first experimental validation of the thermal performance of the SSS cryostat in nominal operating conditions. Temperature sensors mounted in critical locations provide a...

  15. A composite vacuum barrier for the LHC short straight section

    International Nuclear Information System (INIS)

    Jenny, B.; Rohmig, P.; Uriarte, J.M.

    1996-01-01

    The lattice of the CERN Large Hadron Collider (LHC) will contain 384 Short Straight Section (SSS) units, one in every 53 m half-cell. The SSS is composed of a twin aperture high-field superconducting quadrupole and of two combined-function corrector magnets operating in pressurized helium at 1.9 K. The SSS cryostat contains also a barrier for sectorisation of the insulation vacuum. The vacuum barrier is mounted between the helium vessel and the vacuum enclosure. Its functions are to limit the extent of eventual helium leaks and to facilitate the leak detection and the pumping-down from atmospheric pressure. During installation of the LHC, the vacuum barrier permits independent testing of the half-cells, thus enabling higher installation rates. In parallel to a conventional barrier made out of austenitic stainless steel, a barrier of composite material was developed, taking advantage of the lower thermal conductivity of glass fibre reinforced epoxy resin, and with the aim of reducing costs for LHC. The thermo-mechanical design together with the conception and the moulding techniques used for the manufacture of the prototype are described. Bonding techniques for the leak tight stainless steel composite interfaces are presented and test results shown. Results on the mechanical performance and on the helium tests carried out on the prototype are given

  16. Electrical and Magnetic Performance of the LHC Short Straight Sections

    CERN Document Server

    Sanfilippo, S; Bottura, L; Buzio, M; Coccoli, M; García-Pérez, J; Pugnat, P; Sammut, N; Siemko, A; Smirnov, N; Stafiniak, A; Wildner, E

    2006-01-01

    The Short Straight Section (SSS) for the Large Hadron Collider arcs, containing in a common cryostat the lattice quadrupoles and correction magnets, have now entered series production. The foremost features of the lattice quadrupole magnets are a two-in-one structure containing two 56 mm aperture, two-layers coils wound from 15.1 mm wide NbTi cables, enclosed by the stainless steel collars and ferromagnetic yoke, and inserted into the inertia tube. Systematic cryogenic tests are performed at CERN in order to qualify these magnets with respect to their cryogenic and electrical integrity, the quench performance and the field quality in all operating conditions. This paper reports the main results obtained during tests and measurements in superfluid helium. The electrical characteristics, the insulation measurements and the quench performance are compared to the specifications and expected performances for these magnets. The field in the main quadrupole is measured using three independent systems: 10-m lon...

  17. Ring energy selection and extra long straight sections for the Advanced Photon Source

    International Nuclear Information System (INIS)

    1987-04-01

    Recommended criteria are given for the performance of Advanced Photon Source (APS), taking into consideration undulator tunability criteria and their relationship to the storage ring energy and undulator gap, length of straight sections

  18. Manufacture of the straight section chambers for the SPring-8 storage ring

    International Nuclear Information System (INIS)

    Watanabe, K.; Saeki, H.; Sakaue, H.; Ohkuma, H.; Be, S.H.; Oishi, M.; Tuchiya, M.; Nishidono, T.

    1995-01-01

    To carry out the performance test of the vacuum system, we manufactured three different straight section chambers prior to the manufacture of the 48 cell full scale vacuum systems. One of three straight section chambers contains only downstream end absorber, while the other two contain a downstream end absorber, upstream end bellows and a photon beam extraction duct. In this paper, the manufacture of these chambers and their assemblies are described in detail. (author). 1 ref., 3 figs., 3 tabs

  19. Status of PF-ring commissioning after the reconstruction for the straight-sections upgrade

    International Nuclear Information System (INIS)

    Tanimoto, Yasunori; Miyauchi, Hiroshi; Honda, Tohru; Kobayashi, Yukinori

    2006-01-01

    The upgrade project of the straight sections at the PF-ring enables the reinforcement of insertion devices and their beamlines. As a main part of this project, a large-scale reconstruction of the storage ring was carried out from March to September in 2005. The lattice configuration was modified to create short straight sections of 1.4 m and to extend the existing straight sections. Optical functions of the short sections were optimized for short-gap mini-pole undulators as X-ray sources. The first mini-pole undulator SGU no.17 has been operated for a protein crystallography. A recommissioning of the ring was conducted for about one month, and user experiments were restarted on 18th October 2005 according to schedule. The recovery of the beam lifetime due to the process of the vacuum scrubbing has been favorably progressed. (author)

  20. Commissioning of the PF Ring after the Reconstruction for the Straight-sections Upgrade

    International Nuclear Information System (INIS)

    Honda, T.; Asaoka, S.; Cheng, W. X.; Haga, K.; Harada, K.; Hori, Y.; Izawa, M.; Kasuga, T.; Kobayashi, Y.; Maezawa, H.; Mishina, A.; Mitsuhashi, T.; Miyajima, T.; Miyauchi, H.; Nagahashi, S.; Nogami, T.; Obina, T.; Pak, C. O.; Sakanaka, S.; Sasaki, H.

    2007-01-01

    At the 2.5-GeV ring of the Photon Factory, a large reconstruction of the lattice around the straight sections has been accomplished in 2005. Thus reconstruction is the main part of the straight-sections upgrade project to rebuild existing undulators and to increase the number of undulator beamlines. As a result of the reconstruction, four short straight sections have been newly created and the lengths of the existing straight sections have been much extended. To exploit the new straight sections, short-period narrow-gap undulators which have a sufficiently high brilliance in hard x-ray range have been developed. The reconstruction work of the ring was completed in a seven-month shutdown from March to September, 2005. In the area over two thirds of the storage ring, all the quadrupole magnets and all the beam ducts have been renewed and rearranged to construct the new lattice. Recommissioning of the storage ring was finished at the end of October, 2005. Though we made no in-situ baking for the beam ducts, recovery of the beam lifetime has favorably progressed due to the vacuum scrubbing by the synchrotron radiation

  1. Calculation of gas Bremsstrahlung power from straight sections of storage ring at SSRF

    International Nuclear Information System (INIS)

    Hua Zhengdong; Xu Xunjiang; Fang Keming; Xu Jiaqiang

    2008-01-01

    The Shanghai Synchrotron Radiation Facility (SSRF) is a third-generation synchrotron radiation light source with 3.5 GeV in energy, which is composed of the linear accelerator, the booster and the storage ring. The storage ring provides 16 standard straight sections of 6.5 m and 4 long straight sections of 12 meters. Gas Bremsstrahlung (GB) produced by the interaction of the stored beam with the residual gas molecules in straight section, which is so intense and has a very small angular that the GB spectra, the GB power and the GB power distribution should be known. The characters of GB are studied by means of Fluka Monte Carlo code. Our result shows agreement with those obtained by the experiential formulae. (authors)

  2. Bed shear stress distribution in straight channels with arbitrary cross section

    DEFF Research Database (Denmark)

    Christensen, Henrik Bo; Fredsøe, Jørgen

    1998-01-01

    The bed shear stress distribution in straight open channels is affected by mechanisms as bed curvature of the cross section profile, shear diffusion, and secondary currents. This paper compares some analytical and numerical methods to estimate the bed shear stress distribution. The methods...

  3. Broadband Silicon-On-Insulator directional couplers using a combination of straight and curved waveguide sections.

    Science.gov (United States)

    Chen, George F R; Ong, Jun Rong; Ang, Thomas Y L; Lim, Soon Thor; Png, Ching Eng; Tan, Dawn T H

    2017-08-03

    Broadband Silicon-On-Insulator (SOI) directional couplers are designed based on a combination of curved and straight coupled waveguide sections. A design methodology based on the transfer matrix method (TMM) is used to determine the required coupler section lengths, radii, and waveguide cross-sections. A 50/50 power splitter with a measured bandwidth of 88 nm is designed and fabricated, with a device footprint of 20 μm × 3 μm. In addition, a balanced Mach-Zehnder interferometer is fabricated showing an extinction ratio of >16 dB over 100 nm of bandwidth.

  4. The vacuum system for the PEP II high energy ring straight sections

    International Nuclear Information System (INIS)

    Wienands, U.; Daly, E.; Heifets, S.A.; Kulikov, A.; Kurita, N.; Nordby, M.; Perkins, C.; Reuter, E.; Seeman, J.T.; Belser, F.C.; Berg, J.; Holdener, F.R.; Kerns, J.A.; McDaniel, M.R.; Stoeffl, W.

    1995-01-01

    The six straight sections of the PEP II High Energy Ring (HER) serve various functions: lattice tuning, beam injection and abort, providing space for rf cavities, longitudinal and transverse feedback, beam diagnostics and the interaction point. A stainless steel vacuum system has been designed; prototypes are currently being built. Cooling is required due to radiation coming from the last arc dipole and resistive losses in the vacuum chamber. Although the nominal beam current of the HER is 1 A the vacuum system is designed for 3 A to provide margin and an upgrade path. 5 refs., 7 figs

  5. Modelling of flexibles for structural analysis of short straight section of Large Hadron Collider

    International Nuclear Information System (INIS)

    Abhay Kumar; Dutta, Subhajit; Dwivedi, Jishnu; Soni, H.C.

    2003-01-01

    Short Straight Section (SSS) of Large hadron Collider (LRCM) is a 8-meter long structure with a diameter of 1 meter and it houses a twin quadrupole. The cryogens are fed to the Sass through a jumper connection between Cryogenic Distribution Line (QRL) and SSS. The bus bars travel through interconnection bellows to adjoining magnets. CAT is studying the structural behavior of cold mass and the cryostat when subjected to various forces imposed on the SSS under various operating conditions of LHC machine including realignment required to compensate local sinking of the floor of the tunnel during the LHC machine's lifetime. CAT did calculation of reaction forces and moments on the Short Straight Section due to presence of jumper connection last year after the experimental verification of finite element model at CERN. Subsequently, a unified Fe model consisting of cold mass, cold feet, vacuum vessel, main vacuum vessel bellows (large sleeves), magnet interconnects, jumper connection, service module and precision motion jacks is being developed for studying the structural behaviour. (author)

  6. Damping test results for straight sections of 3-inch and 8-inch unpressurized pipes. [PWR; BWR

    Energy Technology Data Exchange (ETDEWEB)

    Ware, A.G.; Thinnes, G.L.

    1984-04-01

    EG and G Idaho is assisting the Nuclear Regulatory Commission and the Pressure Vessel Research Committee in supporting a final position on revised damping values for structural analyses of nuclear piping systems. As part of this program, a series of vibrational tests on unpressurized 3-in. and 8-in. Schedule 40 carbon steel piping was conducted to determine the changes in structural damping due to various parametric effects. The 33-ft straight sections of piping were supported at the ends. Additionally, intermediate supports comprising spring, rod, and constant-force hangers, as well as a sway brace and snubbers, were used. Excitation was provided by low-force-level hammer impacts, a hydraulic shaker, and a 50-ton overhead crane for snapback testing. Data was recorded using acceleration, strain, and displacement time histories. This report presents test results showing the effect of stress level and type of supports on structural damping in piping.

  7. Damping test results for straight sections of 3-inch and 8-inch unpressurized pipes

    International Nuclear Information System (INIS)

    Ware, A.G.; Thinnes, G.L.

    1984-04-01

    EG and G Idaho is assisting the Nuclear Regulatory Commission and the Pressure Vessel Research Committee in supporting a final position on revised damping values for structural analyses of nuclear piping systems. As part of this program, a series of vibrational tests on unpressurized 3-in. and 8-in. Schedule 40 carbon steel piping was conducted to determine the changes in structural damping due to various parametric effects. The 33-ft straight sections of piping were supported at the ends. Additionally, intermediate supports comprising spring, rod, and constant-force hangers, as well as a sway brace and snubbers, were used. Excitation was provided by low-force-level hammer impacts, a hydraulic shaker, and a 50-ton overhead crane for snapback testing. Data was recorded using acceleration, strain, and displacement time histories. This report presents test results showing the effect of stress level and type of supports on structural damping in piping

  8. DFBX boxes -- electrical and cryogenic distribution boxes for the superconducting magnets in the LHC straight sections

    International Nuclear Information System (INIS)

    Zbasnik, Jon P.; Corradi, Carol A.; Gourlay, S.A.; Green, MichaelA.; Hafalia, Aurelio Q.; Kajiyama, Yoichi Jr.; Knolls, Michael J.; LaMantia, Roberto F.; Rasson, Joseph E.; Reavill, Dulie; Turner, William C.

    2002-01-01

    DFBX distribution boxes provide cryogenic and electrical services to superconducting quadrupoles and to a superconducting dipole at either end of four of the long straight sections in the LHC. The DFBX boxes also provide instrumentation and quench protection to the magnets. Current for the quadrupole and the dipole magnet is delivered through leads that combine HTS and gas cooled leads. Current for the 600 A and 120 A correction magnets is provided by pure gas-cooled leads. The bus bars from the leads to the magnets pass through low leak-rate lambda plugs between 1.8 K and 4.4 K. The heat leak into the 1.9 K region from the liquid helium tank is determined by the design of the lambda plugs. This paper describes the DFBX boxes and their function of delivering current and instrumentation signals to the magnets

  9. The Teams from Building 904 celebrated the assembly of the 100th short straight section on 11 April

    CERN Multimedia

    Patrice Loiez

    2005-01-01

    The 100th short straight section for the Large Hadron Collider was assembled at CERN at the beginning of April. These units combine superconducting quadrupoles and other multipole corrector magnets, housed in their cryostats, which are used to guide, focus and fine-tune the beam in the LHC. Building 904, where the 474 short straight sections are being assembled, is often called "Lego Land" by the workers, with a touch of humor and pride because of the wide variety of these sets of magnets and cryostats

  10. Achievement and Evaluation of the Beam Vacuum Performance of the LHC Long Straight Sections

    CERN Document Server

    Bregliozzi, G; Blanchard, S; Hansen, J; Jiménez, J M; Weiss, K

    2008-01-01

    The bake-out and activation of the TiZrV NEG coatings of the 6 km Long Straight Sections (LSS) of the Large Hadron Collider (LHC) is in its final step. After the bakeout and the NEG activation, the average ultimate pressure, over more than one hundred vacuum sectors, is below 10^-10 Pa. Therefore, the nominal requirement for the four experimental insertions is fulfilled. The nominal performances are also ensured for all the insertions housing the collimator systems, the RF cavities and the beam dumping systems. The main difficulties encountered during the bake-out and the activation of the NEG coated chambers is presented and discussed. In particular, the acceptance test and the limiting factors of the reached ultimate pressures are addressed. Furthermore, the influence on the ultimate pressures of the beam components (collimators, beam instrumentation, etc.) is discussed. Finally, preliminary results obtained from a NEG vacuum pilot sector installed in the laboratory and dedicated to the evaluation of the NE...

  11. Summary of Recent Studies of Cryosorbers for LHC Long Straight Sections

    CERN Document Server

    Dostovalov, Rodion; Krasnov, Alexandre

    2005-01-01

    The vacuum chamber inside some cryogenic elements in the LHC long straight sections will have cold bore (CB) at 4.5K and a beam screen (BS) at temperature between 5 and 20K. The gas molecules desorbed due to photons and electrons will pass through the slots on the BS to the shadowed part between the CB and BS. All desorbed gases except H2 could be adsorbed on the CB and BS but a cryosorber is required to pump H2. The new types of anodized aluminum, porous copper and charcoal-based materials were developed and studied to cryopump H2 at temperatures between 10 and 20K. The advantages and disadvantages of cryosorbers and technological problems of development of new similar cryosorbers were defined. The vacuum parameters of LHC vacuum chamber prototypes with charcoal and two types of carbon fiber cryosorbers were measured. The dynamic pressure behavior at BS temperature oscillations was studied for BS with woven carbon fiber to predict the dynamic pressure at nonstandard or transient regimes of the LHC operation....

  12. Axis Measurements, Field Quality and Quench Performance of the First LHC Short Straight Sections

    CERN Document Server

    Sanfilippo, S; Calvi, M; Chohan, V; Durante, M; Hagen, P; Pugnat, P; Smirnov, N; Schnizer, P; Sammut, N; Siemko, A; Simon, F; Stafiniak, A; Todesco, Ezio; Tortschanoff, Theodor; Walckiers, L

    2005-01-01

    The series testing at 1.9 K of the 360 Short Straight Sections (SSS) for the Large Hadron Collider have started at CERN in September 2003. The SSS contain the lattice quadrupoles and correction magnets in a common cryostat. The lattice quadrupoles feature two collared coils with 56 mm bore assembled in a common yoke. The coils are wound in two-layers from 15.1 mm wide NbTi cable, insulated with polyimide tape. The paper reviews the main test results performed in superfluid helium. The magnetic field and magnetic center position of the quadrupoles and associated correctors were measured with two independent systems, namely an automated scanner and a single stretched wire technique. The quench training, the field quality and the magnetic alignment measurements are presented and discussed in terms of the specifications and expected performances of these magnets in the LHC. We discuss in detail the field quality in terms of multipole errors measured at injection and nominal field and decomposed into geometric an...

  13. Dirty Hits

    OpenAIRE

    Clarke, Louise

    2010-01-01

    Issue 9 of the Saatchi Gallery Magazine: Art&Music is dedicated to Sex. The article Dirty Hits invited a cross-section of contemporary artists and musicians to answer: What makes a dirty hit? As one of the artists invited, I wrote an autobiographical piece to reveal how these fumbling, feral sexual experiences of my childhood landscape, along with irrational superstition and folk law inform my life and underpin my work. The article also included an artwork: Louise Clarke, Sip (2009)

  14. Installation and Quality Assurance of the Interconnections between Cryo-assemblies of the LHC Long Straight Sections

    CERN Document Server

    Garion, C; Tock, J P

    2006-01-01

    The interconnections between the cryomagnets and cryogenic utilities in the LHC long Straight Sections constitute the last machine installation activity. They are ensuring continuity of the beam and insulation vacuum systems, cryogenic fluid and electrical circuits and thermal insulation. The assembly is carried out in a constraining tunnel environment with restricted space. Therefore, the assembly sequence has to be well defined and specific tests have to be performed during the interconnection work to secure the reliability of the system and thus to ensure the global accelerator availability. The LHC has 8 long straight insertion zones composed of special cryomagnets involving specific interconnection procedures and QA plans. The aim of this paper is to present the installation and quality assurance procedures implemented for the LHC LSS interconnections. Technologies such as manual and automatic welding and resistive soldering will be described as well as the different quality controls, such as visual and ...

  15. A finite volume study for pressure waves propagation in a straight section of pipeline with caviation

    Directory of Open Access Journals (Sweden)

    C Silva

    2016-09-01

    Full Text Available The main objective of this research was to study the pressure waves propagation generated by a sudden closure of a valve in a straight pipe. The physical model consisted of a head tank that can be pressurized with air, and a copper pipe with a fast-closing ball valve on the downstream end of the line. The cavitation and fluid-structure interaction phenomena were integrated analytically into the one-dimensional continuity and momentum equations, by assuming that the fluid density and the flow area vary with pressure. These equations were solved through a high resolution finite volume method, in combination with others numerical methods such as Taylor series expansion, Newton method, Simpson's Rule and quadratic interpolation. Due to the complexity of the solution procedure, a computational code in FORTRAN 95 language was developed in order to obtain numerical solutions. Several discretizations of the computational grid were achieved to assess their impact on the solution. The model was validated with experimental data and analytic results obtained by other researchers. Several pressure values, in different points of pipe, were compared, and an excellent agreement was found for both cases.

  16. 3-D thermoelastic analysis of the straight section of a PWR hot leg containing a hot spot using BEM

    International Nuclear Information System (INIS)

    Bains, R.S.; Sugimoto, J.

    1995-01-01

    A 3-D steady state thermoelastic analysis using the boundary element method has been successfully employed to investigate the structural response of the straight section of a pressurised water reactor hot leg containing a localised hot spot. With the present severe accident thermal boundary conditions, the analysis produces a nonuniform expansion across the hot leg thickness. This expansion was most predominant on the inner surface, especially at the hot spot location where surface swelling was obtained. Furthermore, the hot spot generates large tangential and axial tensile stresses on the outer surface. These could be detrimental to the integrity of the hot leg by acting as potential sites of crack initiation and subsequent propagation. (orig.)

  17. The New Superfluid Helium Cryostats for the Short Straight Sections of the CERN Large Hadron Collider (LHC)

    CERN Document Server

    Cameron, W; Kurtyka, T; Parma, Vittorio; Renaglia, T; Rifflet, J M; Rohmig, P; Skoczen, Blazej; Tortschanoff, Theodor; Trilhe, P; Védrine, P; Vincent, D

    1998-01-01

    The lattice of the CERN Large Hadron Collider (LHC) contains 364 Short Straight Section (SSS) units, one in every 53 m long half-cell. An SSS consists of three major assemblies: the standard cryostat section, the cryogenic service module, and the jumper connection. The standard cryostat section of an SSS contains the twin aperture high-gradient superconducting quadrupole and two pairs of superconducting corrector magnets, operating in pressurized helium II at 1.9 K. Components for isolating cryostat insulation vacuum, and the cryogenic supply lines, have to be foreseen. Special emphasis is given to the design changes of the SSS following adoption of an external cryogenic supply line (QRL). A jumper connection connects the SSS to the QRL, linking all the cryogenic tubes necessary for the local full-cell cooling loop [at every second SSS]. The jumper is connected to one end of the standard cryostat section via the cryogenic service module, which also houses beam diagnostics, current feedthroughs, and instrument...

  18. Secondary Electron Yield Measurements and Groove Chambers Tests in the PEP-II Beam Line Straights Sections

    International Nuclear Information System (INIS)

    Pivi, M

    2008-01-01

    Beam instability caused by the electron cloud has been observed in positron and proton storage rings and it is expected to be a limiting factor in the performance of the positron Damping Ring (DR) of future Linear Colliders such as ILC and CLIC [1, 2]. In the Positron Low Energy Ring (LER) of the PEP-II accelerator, we have installed vacuum chambers with rectangular grooves in a straight magnetic-free section to test this promising possible electron cloud mitigation technique. We have also installed a special chamber to monitor the secondary electron yield of TiN and TiZrV (NEG) coating, Copper, Stainless Steel and Aluminum under the effect of electron and photon conditioning in situ in the beam line. In this paper, we describe the ongoing R and D effort to mitigate the electron cloud effect for the ILC damping ring, the latest results on in situ secondary electron yield conditioning and recent update on the groove tests in PEP-II

  19. The Assembly of the LHC Short Straight Sections at CERN Work Organization, Quality Assurance and Lessons Learned

    CERN Document Server

    Bourcey, N; López, R; Poncet, A; Parma, V

    2007-01-01

    After 4 years of activity, the assembly of approximately 500 Short Straight Sections (SSS) for the LHC has come to an end at the beginning of 2007. This activity, which was initially foreseen in European industry, was in-sourced at CERN because of the insolvency of the prime contractor. While the quadrupole cold masses were produced in industry, the assembly within their cryostats was transferred to CERN and executed by an external company under a result-oriented contract. CERN procured cryostat components, set up a dedicated 2000 m2 assembly hall with all the specific assembly equipment and tooling and defined the assembly and testing procedures. The contractor took up responsibility for the delivery, on time, of assemblies according to the required quality. A dedicated CERN production and quality assurance team was constituted. A specific quality assurance plan was set up involving 2 additional contractors responsible for weld inspections on a total of about 20'000 assembly welds and the execution of about ...

  20. Short Straight Sections in the LHC Matching Sections (MS SSS) An Extension of the Arc Cryostats to Fulfil Specific Machine Functionalities

    CERN Document Server

    Parma, V; Lutton, F

    2005-01-01

    The LHC insertions require 50 specific superconducting quadrupoles in the matching sections, operating either in 1.9 K superfluid helium or in boiling helium at 4.5 K. These magnets are assembled together with corrector magnets in cold masses, and are inserted in individual cryostats to form the MS Short Straight Sections (MS SSS). The variety of quadrupoles and corrector magnets leads to 10 families of cold masses, with lengths ranging from 5 to 12 m and weights ranging from 60 to 140 kN. The MS SSS need to fulfil specific requirements related to the collider topology, its cryogenic layout and the powering scheme. Most MS SSS are standalone cryogenic and super-conducting units, i.e. they are not in the continuous arc cryostat, and therefore need dedicated cryogenic and electrical feeding. Specially designed cryostat end-caps are required to close the vacuum vessels at each end, which include low heat in-leak Cold-to-Warm transitions (CWT) for the beam tubes and 6 kA local electrical feedthrough for powering...

  1. Proposal to negotiate an amendment to an existing contract for the supply of additional vacuum vessels for the short-straight sections of the LHC

    CERN Document Server

    2005-01-01

    This document concerns the proposal to negotiate an amendment to an existing contract for the supply of additional vacuum vessels for the short-straight sections of the LHC. For the reasons explained in this document, the Finance Committee is invited to approve an amendment to an existing contract with SLOVENSKE ENERGETICKE STROJARNE (SK) for the supply of 25 additional vacuum vessels for the short-straight sections for the LHC for an amount of 140 000 euros (216 999 Swiss francs), subject to revision for inflation, bringing the total to a maximum amount of 6 176 855 euros (9 574 097 Swiss francs), subject to revision for inflation. The rate of exchange used is that stipulated in the tender.

  2. Hit Parade

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2017-01-01

    Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Kulturnatten 2017, ITU, Copenhagen, DK, Oct 13, 2017.......Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Kulturnatten 2017, ITU, Copenhagen, DK, Oct 13, 2017....

  3. Hit Parade

    DEFF Research Database (Denmark)

    Cermak, Daniel; Wrighton, Max Alexander; Backe, Hans-Joachim

    2016-01-01

    Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Demo Night, ITU, Copenhagen, DK, Oct 5, 2016.......Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Demo Night, ITU, Copenhagen, DK, Oct 5, 2016....

  4. Hit Parade

    DEFF Research Database (Denmark)

    Cermak, Daniel; Wrighton, Max Alexander; Backe, Hans-Joachim

    2016-01-01

    Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Kulturnatten 2016, Danish Science Ministry, Copenhagen, DK, Oct 14, 2016.......Daniel Cermak-Sassenrath, Max Alexander Wrighton, Hans-Joachim Backe. Hit Parade. Installation. Kulturnatten 2016, Danish Science Ministry, Copenhagen, DK, Oct 14, 2016....

  5. Proposal to Negotiate an Amendment to an Existing Contract and Several Contracts for the Supply and Assembly of the LHC Short Straight Section Cryostats

    CERN Document Server

    2002-01-01

    Following the insolvency of a major contractor, CERN proposes to negotiate an amendment to an existing contract and to place several contracts for the supply of 360 LHC arc short straight section cryostats and their assembly, eight spare cryostat units and components for 64 LHC dispersion suppressor short straight section cryostats. The Finance Committee is therefore invited to approve an amendment to an existing contract with the consortium: &8721; INTERTEC (DK) - CEGELEC (FR) - SPIE TRINDEL (FR) to include assembly of the LHC arc short straight sections, for an additional amount of 4 088 470 euros (6 205 480 Swiss francs), subject to revision for inflation after 31 December 2002; the consortium has indicated the following distribution by country of the contract value covered by this adjudication proposal : DK - 52%, FR - 48%; and to the negotiation of contracts for the supply of related major components with the firms: &8721; SES (SK) for the supply of vacuum vessels for an amount of 5 538 533 euros...

  6. 42 CFR 495.344 - Approval of the State Medicaid HIT plan, the HIT PAPD and update, the HIT IAPD and update, and...

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Approval of the State Medicaid HIT plan, the HIT PAPD and update, the HIT IAPD and update, and the annual HIT IAPD. 495.344 Section 495.344 Public... Requirements Specific to the Medicaid Program § 495.344 Approval of the State Medicaid HIT plan, the HIT PAPD...

  7. Proposal to negotiate an amendment to an existing contract for the supply of the cold masses of the LHC short straight sections

    CERN Document Server

    2006-01-01

    This document concerns the proposal to negotiate an amendment to an existing contract for the supply of the main superconducting quadrupoles and assembly of the cold masses of the LHC short straight sections. For the reasons explained in this document, the Finance Committee is invited to approve an amendment to an existing contract with the firm ACCEL INSTRUMENTS (DE) for an amount of 1 513 618 euros (2 411 496 Swiss francs), bringing the total to a maximum amount of 40 815 743 euros (65 027 641 Swiss francs), subject to revision for inflation. The amount in Swiss francs has been calculated using the present rate of exchange.

  8. Effect of a uniform magnetic induction field upon the flow of an electrically conducting fluid placed in a straight rectangular cross section, one of the walls of which, characterized by an infinite conductivity, presents uniform translation movement

    International Nuclear Information System (INIS)

    Herve, Patrick

    1975-01-01

    This is a theoretical study of an electrically viscous fluid flowing in a straight rectangular cross section channel, a wall of which, infinitely conducting, is placed perpendicularly to the direction of a uniform magnetic induction field. The three other walls of the channel being electrically insulating, remain motionless. Formulas giving velocity distribution law in the straight section of the flow in relation to the Hartmann's number, curves illustrating the accelerating effect produced across the whole section, by the application of the magnetic induction field, and example for the distribution of the electric current lines in case of a square section are given [fr

  9. Structural Analysis of an Integrated Model of Short Straight Section, Service Module, Jumper Connection and Magnet Interconnects for the Large Hadron Collider

    CERN Document Server

    Dutta, S; Kumar, A; Skoczen, B; Soni, H C

    2004-01-01

    The Short Straight Section (SSS) of the Large Hadron Collider (LHC) may undergo relative displacements between cold-mass and cryostat for the following three reasons: - Fabrication tolerance of interconnection bellows - Global smoothing after pre-alignment - Ground motion in a sector of the LHC tunnel The forces responsible for such displacements stem from finite stiffness of interconnect bellows & metal hoses of the internal piping of the jumper connection and from relatively flexible 'glass fibre reinforced epoxy' (GFRE) composite supports of the cold mass. In addition, the vacuum jacket of the jumper connection and the large sleeves attached to both ends of SSS produce elastic deformations of the cryostat vessel. A unified finite element model consisting of cryostat, large sleeves, vacuum jacket of jumper, interconnection bellows, internal piping of jumper, composite cold supports and alignment jacks has been prepared. The knowledge of the position of the cold mass with respect to its cryostat under va...

  10. 26 CFR 1.167(b)-1 - Straight line method.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Straight line method. 1.167(b)-1 Section 1.167(b... Straight line method. (a) In general. Under the straight line method the cost or other basis of the... may be reduced to a percentage or fraction. The straight line method may be used in determining a...

  11. A Modular Design for the 56 Variants of the Short Straight Section in the Arcs of the Large Hadron Collider (LHC)

    CERN Document Server

    Bergot, J B; Nielsen, L; Parma, Vittorio; Peyrot, M; Renaglia, T; Rifflet, J M; Rohmig, P; Roy, E; Simon, F; Tortschanoff, Theodor; Vincent, D

    2000-01-01

    The 360 Short Straight Sections (SSS) necessary for the eight arcs of the LHC machine have to fulfil different requirements. Their main function is to house the lattice two-in-one superconducting quadrupole and various correction magnets, all operating at 1.9 K in a superfluid helium bath. The magnetic and powering schemes of the arcs and the fact that the two proton beams alternate between the inner and outer magnet channels impose 24 different combinations of magnet assemblies, all housed in an identical helium enclosure. The cryogenic architecture of the LHC machine is based on cryogenic loops spanning over one half-cell (53 m) for the 4.6-20 K circuit, over a full cell (107 m) for the 1.9 K circuits, up to the full arc (about 2.3 km) for the shield cooling line. This cryogenic layout, when superimposed to the magnetic scheme, further complicated by the cryostat insulation vacuum sectorisation every 2 cells, creates additional assembly variants, up to a total number of 56. The required flexibility in the m...

  12. A modified straight leg raise test to differentiate between sural nerve pathology and Achilles tendinopathy. A cross-sectional cadaver study

    NARCIS (Netherlands)

    Coppieters, M.W.J.; Crooke, J.L.; Lawrenson, P.R.; Khoo, S.J.; Skulstad, T.; Bet-Or, Y.

    2015-01-01

    Background: A modified straight leg raise test for the sural nerve (SLRSURAL) has been proposed to assist in the differential diagnosis of sural nerve pathology in people with posterior calf or ankle pain, or lateral foot pain. The biomechanical rationale is that strain in the

  13. 14 CFR 417.215 - Straight-up time analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Straight-up time analysis. 417.215 Section..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.215 Straight-up time analysis. A flight safety analysis must establish the straight-up time for a launch for use as a flight...

  14. 7 CFR 29.6128 - Straight Stripped (X Group).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Straight Stripped (X Group). 29.6128 Section 29.6128... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6128 Straight Stripped (X Group). This group consists of..., and tolerances X1 Fine Quality Straight Stripped. Heavy, ripe, firm, semielastic, normal strength and...

  15. The effect of road and environmental characteristics on pedestrian hit-and-run accidents in Ghana.

    Science.gov (United States)

    Aidoo, Eric Nimako; Amoh-Gyimah, Richard; Ackaah, Williams

    2013-04-01

    The number of pedestrians who have died as a result of being hit by vehicles has increased in recent years, in addition to vehicle passenger deaths. Many pedestrians who were involved in road traffic accident died as a result of the driver leaving the pedestrian who was struck unattended at the scene of the accident. This paper seeks to determine the effect of road and environmental characteristics on pedestrian hit-and-run accidents in Ghana. Using pedestrian accident data extracted from the National Road Traffic Accident Database at the Building and Road Research Institute (BRRI) of the Council for Scientific and Industrial Research (CSIR), Ghana, a binary logit model was employed in the analysis. The results from the estimated model indicate that fatal accidents, unclear weather, nighttime conditions, and straight and flat road sections without medians and junctions significantly increase the likelihood that the vehicle driver will leave the scene after hitting a pedestrian. Thus, integrating median separation and speed humps into road design and construction and installing street lights will help to curb the problem of pedestrian hit-and-run accidents in Ghana. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Nedley Depression Hit Hypothesis

    OpenAIRE

    Nedley, Neil; Ramirez, Francisco E.

    2014-01-01

    Depression is often diagnosed using the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria. We propose how certain lifestyle choices and non-modifiable factors can predict the development of depression. We identified 10 cause categories (hits or ?blows? to the brain) and theorize that four or more active hits could trigger a depression episode. Methods. A sample of 4271 participants from our community-based program (70% female; ages 17-94 years) was assessed ...

  17. 75 FR 62399 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-10-08

    ... Technology; HIT Standards Committee Schedule for the Assessment of HIT Policy Committee Recommendations.... SUMMARY: Section 3003(b)(3) of the American Recovery and Reinvestment Act of 2009 mandates that the HIT Standards Committee develop a schedule for the assessment of policy recommendations developed by the HIT...

  18. The SVT Hit Buffer

    International Nuclear Information System (INIS)

    Belforte, S.; Dell'Orso, M.; Donati, S.

    1996-01-01

    The Hit Buffer is part of the Silicon Vertex Tracker, a trigger processor dedicated to the reconstruction of particle trajectories in the Silicon Vertex Detector and the Central Tracking Chamber of the Collider Detector at Fermilab. The Hit Buffer is a high speed data-traffic node, where thousands of words are received in arbitrary order and simultaneously organized in an internal structured data base, to be later promptly retrieved and delivered in response to specific requests. The Hit Buffer is capable of processing data at a rate of 25 MHz, thanks to the use of special fast devices like Cache-Tag RAMs and high performance Erasable Programmable Logic Devices from the XILINX XC7300 family

  19. Influence of uneven distribution of coupling mass on locomotive wheel pairs, its tractive power, straight and curved sections of industrial rail tracks.

    Science.gov (United States)

    Keropyan, A. M.; Kantovich, L. I.; Voronin, B. V.; Kuziev, D. A.; Zotov, V. V.

    2017-10-01

    This article deals with the problems of unloading the axes of wheel sets of locomotives of industrial railway transport by the example of exploitation in conditions of open chasing works. Studies have established that the displacement of the center of mass of an open-pit locomotive depends primarily on the height of the center of gravity, the height of the location of the hook of the locomotive coupling over the rails and the slope of the track. Therefore, to increase the coefficient of utilization of the adhesive weight and to ensure rational operating conditions, it is necessary to provide an adjustable displacement of the locomotive’s center of mass taking into account the actual operating conditions, including when driving on rectilinear and curvilinear sections of the track. Analysis of calculation results showed that for the traction unit OPE1 when driving in traction mode in close to the extreme operating conditions, it is necessary to provide a constructive solution for displacement of the center of mass of the locomotive up to 0.5 m in the course of movement of the locomotive’s center of mass.

  20. Straight scaling FFAG beam line

    International Nuclear Information System (INIS)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-01-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called “straight scaling law”, and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  1. Straight scaling FFAG beam line

    Science.gov (United States)

    Lagrange, J.-B.; Planche, T.; Yamakawa, E.; Uesugi, T.; Ishi, Y.; Kuriyama, Y.; Qin, B.; Okabe, K.; Mori, Y.

    2012-11-01

    Fixed field alternating gradient (FFAG) accelerators are recently subject to a strong revival. They are usually designed in a circular shape; however, it would be an asset to guide particles with no overall bend in this type of accelerator. An analytical development of a straight FFAG cell which keeps zero-chromaticity is presented here. A magnetic field law is thus obtained, called "straight scaling law", and an experiment has been conducted to confirm this zero-chromatic law. A straight scaling FFAG prototype has been designed and manufactured, and horizontal phase advances of two different energies are measured. Results are analyzed to clarify the straight scaling law.

  2. Standing "Straight" up to Homophobia: Straight Allies' Involvement in GSAs

    Science.gov (United States)

    Lapointe, Alicia Anne

    2015-01-01

    This qualitative study captures the experiences of four straight allies' and one gay youth involvement in gay--straight alliances (GSAs) at their Ontario, Canada, high schools. Participants' motivations for becoming GSA members and their roles as allies are examined. Queer theoretical perspectives, as espoused by Britzman (1995, 1998) and Linville…

  3. 26 CFR 1.9001 - Statutory provisions; Retirement-Straight Line Adjustment Act of 1958.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Statutory provisions; Retirement-Straight Line... provisions; Retirement-Straight Line Adjustment Act of 1958. Section 94 of the Technical Amendments Act of 1958 (72 Stat. 1669) provides as follows: Sec. 94. Change from retirement to straight line method of...

  4. 21 CFR 70.20 - Packaging requirements for straight colors (other than hair dyes).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Packaging requirements for straight colors (other than hair dyes). 70.20 Section 70.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... straight colors (other than hair dyes). Straight colors shall be packaged in containers which prevent...

  5. FIXTURING DEVICE FOR DRILLING A STRAIGHT SHAFT

    Directory of Open Access Journals (Sweden)

    SUSAC, Florin

    2017-05-01

    Full Text Available The paper presents a fixturing device used for machining by drilling a straight shaft. The shaft was manufactured on EMCO CONCEPT TURN 55 CNC. The blank used was a bar with circular cross-section. The orientation and fixing scheme of the part and the orientation elements for fixturing device are presented as they were drawn in Autodesk Inventor and AutoCAD software.

  6. Straight Ahead in Microgravity

    Science.gov (United States)

    Wood, S. J.; Vanya, R. D.; Clement, G.

    2014-01-01

    This joint ESA-NASA study will address adaptive changes in spatial orientation related to the subjective straight ahead, and the use of a vibrotactile sensory aid to reduce perceptual errors. The study will be conducted before and after long-duration expeditions to the International Space Station (ISS) to examine how spatial processing of target location is altered following exposure to microgravity. This project specifically addresses the sensorimotor research gap "What are the changes in sensorimotor function over the course of a mission?" Six ISS crewmembers will be requested to participate in three preflight sessions (between 120 and 60 days prior to launch) and then three postflight sessions on R+0/1 day, R+4 +/-2 days, and R+8 +/-2 days. The three specific aims include: (a) fixation of actual and imagined target locations at different distances; (b) directed eye and arm movements along different spatial reference frames; and (c) the vestibulo-ocular reflex during translation motion with fixation targets at different distances. These measures will be compared between upright and tilted conditions. Measures will then be compared with and without a vibrotactile sensory aid that indicates how far one has tilted relative to the straight-ahead direction. The flight study was been approved by the medical review boards and will be implemented in the upcoming Informed Crew Briefings to solicit flight subject participation. Preliminary data has been recorded on 6 subjects during parabolic flight to examine the spatial coding of eye movements during roll tilt relative to perceived orientations while free-floating during the microgravity phase of parabolic flight or during head tilt in normal gravity. Binocular videographic recordings obtained in darkness allowed us to quantify the mean deviations in gaze trajectories along both horizontal and vertical coordinates relative to the aircraft and head orientations. During some parabolas, a vibrotactile sensory aid provided

  7. Diffraction at a Straight Edge

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 5. Diffraction at a Straight Edge: A Gem from Sommerfeld's Work in Classical Physics. Rajaram Nityananda. General Article Volume 20 Issue 5 May 2015 pp 389-400 ...

  8. Health Information Technology (HIT) Adaptation: Refocusing on the Journey to Successful HIT Implementation.

    Science.gov (United States)

    Yen, Po-Yin; McAlearney, Ann Scheck; Sieck, Cynthia J; Hefner, Jennifer L; Huerta, Timothy R

    2017-09-07

    In past years, policies and regulations required hospitals to implement advanced capabilities of certified electronic health records (EHRs) in order to receive financial incentives. This has led to accelerated implementation of health information technologies (HIT) in health care settings. However, measures commonly used to evaluate the success of HIT implementation, such as HIT adoption, technology acceptance, and clinical quality, fail to account for complex sociotechnical variability across contexts and the different trajectories within organizations because of different implementation plans and timelines. We propose a new focus, HIT adaptation, to illuminate factors that facilitate or hinder the connection between use of the EHR and improved quality of care as well as to explore the trajectory of changes in the HIT implementation journey as it is impacted by frequent system upgrades and optimizations. Future research should develop instruments to evaluate the progress of HIT adaptation in both its longitudinal design and its focus on adaptation progress rather than on one cross-sectional outcome, allowing for more generalizability and knowledge transfer. ©Po-Yin Yen, Ann Scheck McAlearney, Cynthia J Sieck, Jennifer L Hefner, Timothy R Huerta. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 07.09.2017.

  9. Computational Physics' Greatest Hits

    Science.gov (United States)

    Bug, Amy

    2011-03-01

    The digital computer, has worked its way so effectively into our profession that now, roughly 65 years after its invention, it is virtually impossible to find a field of experimental or theoretical physics unaided by computational innovation. It is tough to think of another device about which one can make that claim. In the session ``What is computational physics?'' speakers will distinguish computation within the field of computational physics from this ubiquitous importance across all subfields of physics. This talk will recap the invited session ``Great Advances...Past, Present and Future'' in which five dramatic areas of discovery (five of our ``greatest hits'') are chronicled: The physics of many-boson systems via Path Integral Monte Carlo, the thermodynamic behavior of a huge number of diverse systems via Monte Carlo Methods, the discovery of new pharmaceutical agents via molecular dynamics, predictive simulations of global climate change via detailed, cross-disciplinary earth system models, and an understanding of the formation of the first structures in our universe via galaxy formation simulations. The talk will also identify ``greatest hits'' in our field from the teaching and research perspectives of other members of DCOMP, including its Executive Committee.

  10. Conceptual Design of ILC Damping Ring Wiggler Straight Vacuum System

    International Nuclear Information System (INIS)

    Marks, S.; Kennedy, K.; Plate, D.; Schlueter, R.D.; Zisman, M.

    2007-01-01

    The positron and electron damping rings for the International Linear Collider will contain long straight sections consisting of twenty wiggler/quadrupole pairs. The wigglers will be based upon the CESR superconducting design. There are a number of challenges associated with the design of the wiggler straight vacuum system, in particular, the absorption of photon power generated by the wigglers. This paper will present the overall conceptual design of the wiggler straight vacuum system developed for the ILC Reference Design Report. Particular emphasis will be placed on photon power load calculations and the absorber design

  11. Exact equivalent straight waveguide model for bent and twisted waveguides

    DEFF Research Database (Denmark)

    Shyroki, Dzmitry

    2008-01-01

    Exact equivalent straight waveguide representation is given for a waveguide of arbitrary curvature and torsion. No assumptions regarding refractive index contrast, isotropy of materials, or particular morphology in the waveguide cross section are made. This enables rigorous full-vector modeling...... of in-plane curved or helically wound waveguides with use of available simulators for straight waveguides without the restrictions of the known approximate equivalent-index formulas....

  12. Straight nearness spaces | Bentley | Quaestiones Mathematicae

    African Journals Online (AJOL)

    Straight spaces are spaces for which a continuous map defined on the space which is uniformly continuous on each set of a finite closed cover is then uniformly continuous on the whole space. Previously, straight spaces have been studied in the setting of metric spaces. In this paper, we present a study of straight spaces in ...

  13. Straightness measurement of large machine guideways

    Directory of Open Access Journals (Sweden)

    W. Ptaszyñski

    2011-10-01

    Full Text Available This paper shows the guideway types of large machines and describes problems with their straightness measurement. A short description of straightness measurement methods and the results of investigation in straightness of 10 meter long guideways of a CNC machine by means of the XL-10 Renishaw interferometer are also presented.

  14. Automatic Sound Generation for Spherical Objects Hitting Straight Beams Based on Physical Models.

    Science.gov (United States)

    Rauterberg, M.; And Others

    Sounds are the result of one or several interactions between one or several objects at a certain place and in a certain environment; the attributes of every interaction influence the generated sound. The following factors influence users in human/computer interaction: the organization of the learning environment, the content of the learning tasks,…

  15. Mixed Hitting-Time Models

    NARCIS (Netherlands)

    Abbring, J.H.

    2009-01-01

    We study mixed hitting-time models, which specify durations as the first time a Levy process (a continuous-time process with stationary and independent increments) crosses a heterogeneous threshold. Such models of substantial interest because they can be reduced from optimal-stopping models with

  16. Combined hit theory-microdosimetric explanation of cellular radiobiological action

    International Nuclear Information System (INIS)

    Bond, V.P.; Varma, M.N.

    1983-01-01

    Hit theory is combined with microdosimetry in a stochastic approach that explains the observed responses of cell populations exposed in radiation fields of different qualities. The central thesis is that to expose a population of cells in a low-level radiation field is to subject the cells to the potential for interaction with charged particles in the vicinity of the cells, quantifiable in terms of the charged particle fluence theta. When such an interaction occurs there is a resulting stochastic transfer of energy to a critical volume (CV) of cross section sigma, within the cell(s). The severity of cell injury is dependent on the amount of energy thus imparted, or the hit size. If the severity is above some minimal level, there is a non-zero probability that the injury will result in a quantal effect (e.g., a mutational or carcinogenic initial event, cell transformation). A microdosimetric proportional counter, viewed here as a phantom cell CV that permits measurements not possible in the living cell, is used to determine the incidence of hit cells and the spectrum of hit sizes. Each hit is then weighted on the basis of an empirically-determined function that provides the fraction of cells responding quantally, as a function of hit size. The sum of the hits so weighted provides the incidence of quantally-responding cells, for any amount of exposure theta in a radiation field of any quality or mixture qualities. The hit size weighting function for pink mutations in Tradescantia is discussed, as are its implications in terms of a replacement for RBE and dose equivalent. 14 references, 9 figures

  17. Modifications in straight wire treatment.

    Science.gov (United States)

    Cardona, Alvin

    2010-01-01

    Orthodontic treatments have been modified with each new generation of clinicians. Today the emphasis is on facial esthetics and healthy temporomandibular joints. With orthopedic treatment, we can develop dental arches to get the necessary space to align the teeth and we can reach adequate function and esthetics, all within relatively good stability. By combining two-phase treatment with low friction fixed orthodontics and super elastic wires we produce light but continuous forces and we can provide better treatment than before. These types of forces cause physiological and functional orthopedic orthodontic reactions. The purpose of this article is to demonstrate our fixed orthopedic and orthodontic approach called "Modified Straight Wire" or "Physiologic Arch Technique." This technique is very successful with our patients because it can exert slow and continuous forces with minimal patient cooperation.

  18. 77 FR 32639 - HIT Standards Committee and HIT Policy Committee; Call for Nominations

    Science.gov (United States)

    2012-06-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee and HIT Policy Committee; Call for... Health Information Technology Policy Committee (HITPC). Name of Committees: HIT Standards Committee and HIT Policy Committee. General Function of the Committees: The HITSC is charged to provide...

  19. Weighted straight skeletons in the plane.

    Science.gov (United States)

    Biedl, Therese; Held, Martin; Huber, Stefan; Kaaser, Dominik; Palfrader, Peter

    2015-02-01

    We investigate weighted straight skeletons from a geometric, graph-theoretical, and combinatorial point of view. We start with a thorough definition and shed light on some ambiguity issues in the procedural definition. We investigate the geometry, combinatorics, and topology of faces and the roof model, and we discuss in which cases a weighted straight skeleton is connected. Finally, we show that the weighted straight skeleton of even a simple polygon may be non-planar and may contain cycles, and we discuss under which restrictions on the weights and/or the input polygon the weighted straight skeleton still behaves similar to its unweighted counterpart. In particular, we obtain a non-procedural description and a linear-time construction algorithm for the straight skeleton of strictly convex polygons with arbitrary weights.

  20. Straight sinus thrombosis during neurosurgical operation.

    Science.gov (United States)

    Kawano, Hiroto; Nitta, Naoki; Nozaki, Kazuhiko

    2016-01-01

    Perioperative straight sinus thrombosis is extremely rare. A 59-year-old female was admitted to our department because of incidentally found small anterior cerebral artery (A1) aneurysm with microbleeding. After clipping the cerebral aneurysm, she had delayed emergence from anesthesia, total aphasia, and right hemiparesis. Fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) of the head showed hyperintensity in the bilateral caudate nuclei, putamina, and thalami, and computed tomography of the head showed a hyperdense straight sinus, suggesting straight sinus thrombosis. Her neurologic symptoms improved gradually, and she achieved a full clinical recovery, with radiological evidence of recanalization of the straight sinus at follow-up. The possibility of straight sinus thrombosis should be considered in postoperative patients with unexplained postoperative deficits when MRI demonstrates hyperintensity in the bilateral basal ganglia and thalami on FLAIR signal images.

  1. Quantum walks with infinite hitting times

    International Nuclear Information System (INIS)

    Krovi, Hari; Brun, Todd A.

    2006-01-01

    Hitting times are the average time it takes a walk to reach a given final vertex from a given starting vertex. The hitting time for a classical random walk on a connected graph will always be finite. We show that, by contrast, quantum walks can have infinite hitting times for some initial states. We seek criteria to determine if a given walk on a graph will have infinite hitting times, and find a sufficient condition, which for discrete time quantum walks is that the degeneracy of the evolution operator be greater than the degree of the graph. The set of initial states which give an infinite hitting time form a subspace. The phenomenon of infinite hitting times is in general a consequence of the symmetry of the graph and its automorphism group. Using the irreducible representations of the automorphism group, we derive conditions such that quantum walks defined on this graph must have infinite hitting times for some initial states. In the case of the discrete walk, if this condition is satisfied the walk will have infinite hitting times for any choice of a coin operator, and we give a class of graphs with infinite hitting times for any choice of coin. Hitting times are not very well defined for continuous time quantum walks, but we show that the idea of infinite hitting-time walks naturally extends to the continuous time case as well

  2. Building 904, where the short straight sections are being assembled, is often called "Legoland" by the workers because of the wide variety of these sets of magnets and cryostats.

    CERN Multimedia

    2005-01-01

    Très peu de gens se doutent probablement du travail assidu qui s'exécute au bâtiment 904 de Prévessin. Un hall de 2000 m2, ancien atelier d'usinage situé à l'arrière du bâtiment, a été rénové et aménagé pour l'assemblage des 474 sections droites courtes (SSS) requises pour le LHC. Depuis que le site est devenu opérationnel, en janvier 2004, la cadence de production s'est progressivement accélérée et la 100e section droite courte a été terminée la semaine dernière.

  3. A Faster Algorithm for Computing Straight Skeletons

    KAUST Repository

    Cheng, Siu-Wing

    2014-09-01

    We present a new algorithm for computing the straight skeleton of a polygon. For a polygon with n vertices, among which r are reflex vertices, we give a deterministic algorithm that reduces the straight skeleton computation to a motorcycle graph computation in O(n (logn)logr) time. It improves on the previously best known algorithm for this reduction, which is randomized, and runs in expected O(n√h+1log2n) time for a polygon with h holes. Using known motorcycle graph algorithms, our result yields improved time bounds for computing straight skeletons. In particular, we can compute the straight skeleton of a non-degenerate polygon in O(n (logn) logr + r 4/3 + ε ) time for any ε > 0. On degenerate input, our time bound increases to O(n (logn) logr + r 17/11 + ε ).

  4. A Faster Algorithm for Computing Straight Skeletons

    KAUST Repository

    Mencel, Liam A.

    2014-05-06

    We present a new algorithm for computing the straight skeleton of a polygon. For a polygon with n vertices, among which r are reflex vertices, we give a deterministic algorithm that reduces the straight skeleton computation to a motorcycle graph computation in O(n (log n) log r) time. It improves on the previously best known algorithm for this reduction, which is randomised, and runs in expected O(n √(h+1) log² n) time for a polygon with h holes. Using known motorcycle graph algorithms, our result yields improved time bounds for computing straight skeletons. In particular, we can compute the straight skeleton of a non-degenerate polygon in O(n (log n) log r + r^(4/3 + ε)) time for any ε > 0. On degenerate input, our time bound increases to O(n (log n) log r + r^(17/11 + ε))

  5. A Faster Algorithm for Computing Straight Skeletons

    KAUST Repository

    Cheng, Siu-Wing; Mencel, Liam A.; Vigneron, Antoine E.

    2014-01-01

    We present a new algorithm for computing the straight skeleton of a polygon. For a polygon with n vertices, among which r are reflex vertices, we give a deterministic algorithm that reduces the straight skeleton computation to a motorcycle graph computation in O(n (logn)logr) time. It improves on the previously best known algorithm for this reduction, which is randomized, and runs in expected O(n√h+1log2n) time for a polygon with h holes. Using known motorcycle graph algorithms, our result yields improved time bounds for computing straight skeletons. In particular, we can compute the straight skeleton of a non-degenerate polygon in O(n (logn) logr + r 4/3 + ε ) time for any ε > 0. On degenerate input, our time bound increases to O(n (logn) logr + r 17/11 + ε ).

  6. Simulation and analysis of the transmission properties of curved-straight neutron guide systems

    International Nuclear Information System (INIS)

    Copley, J.R.D.; Mildner, D.F.R.

    1992-01-01

    This paper reports that the spatial intensity distribution of neutrons emerging from a curved guide is far from uniform, particularly at short wavelengths, and curved guides are sometimes followed by a straight section of guide to make the intensity distribution more uniform. The behavior of neutrons within curved-straight neutron guide systems is examined using both ray-tracing and analytical approaches to the problem. The intensity distribution within the straight guide tends to wash from one side of the guide to the other. The amplitude of this transverse wave decreases with increasing guide length, and the characteristic length of the wave decreases with increasing neutron wavelength

  7. Propagation of ovalization along straight pipes and elbows

    International Nuclear Information System (INIS)

    Millard, A.; Roche, R.L.

    1981-01-01

    The aim of this paper is to present analytical solutions for the propagation of evalization and the variation of the flexibility factor along pipe bends terminated by straight pipes or flanges, under in-plane bending, assuming an elastic material behaviour. The influence of the various strains in analysed in the simple case of a straight pipe, subjected to an elliptical cross-section shape deformation at one end. The results enlighten the very important part played by the distorsion in the propagation. They have been compared with finite elements solutions and with simple experiments. The solution is developed for an elbow terminated by a straight pipe or a flange, following the Von Karman's approach: local displacements are expanded in Fourier series, the coefficients of which vary along the curvilinear abscissa, like the rotation of the cross-section as a whole; the differential equations as well as the boundary conditions are found by minimization of the total potential energy of the assembly. The solutions are compared to existing and experimental results. (orig./HP)

  8. Pattern recognition with vector hits

    International Nuclear Information System (INIS)

    Frühwirth, R

    2012-01-01

    Trackers at the future high-luminosity LHC, designed to have triggering capability, will feature layers of stacked modules with a small stack separation. This will allow the reconstruction of track stubs or vector hits with position and direction information, but lacking precise curvature information. This opens up new possibilities for track finding, online and offline. Two track finding methods, the Kalman filter and the convergent Hough transform are studied in this context. Results from a simplified fast simulation are presented. It is shown that the performance of the methods depends to a large extent on the size of the stack separation. We conclude that the detector design and the choice of the track finding algorithm(s) are strongly coupled and should proceed conjointly.

  9. 77 FR 23250 - HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations

    Science.gov (United States)

    2012-04-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations AGENCY: Office of the National Coordinator for Health Information... 2009 mandates that the HIT Standards Committee develop a schedule for the assessment of policy...

  10. 76 FR 25355 - HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations

    Science.gov (United States)

    2011-05-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations AGENCY: Office of the National Coordinator for Health Information... 2009 mandates that the HIT Standards Committee develop a schedule for the assessment of policy...

  11. 78 FR 29134 - HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee; Schedule for the Assessment of HIT Policy Committee Recommendations AGENCY: Office of the National Coordinator for Health Information... 2009 mandates that the HIT Standards Committee develop a schedule for the assessment of policy...

  12. Developing Health Information Technology (HIT) Programs and HIT Curriculum: The Southern Polytechnic State University Experience

    Science.gov (United States)

    Zhang, Chi; Reichgelt, Han; Rutherfoord, Rebecca H.; Wang, Andy Ju An

    2014-01-01

    Health Information Technology (HIT) professionals are in increasing demand as healthcare providers need help in the adoption and meaningful use of Electronic Health Record (EHR) systems while the HIT industry needs workforce skilled in HIT and EHR development. To respond to this increasing demand, the School of Computing and Software Engineering…

  13. Low Horizontal Beta Function In Long Straights Of The NSLS-II Lattice

    International Nuclear Information System (INIS)

    Fanglei, L.; Bengtsson, J.; Guo, W.; Krinsky, S.; Li, Y.; Yang, L.

    2011-01-01

    The NSLS-II storage ring lattice is comprised of 30 DBA cells arranged in 15 superperiods. There are 15 long straight sections (9.3m) for injection, RF and insertion devices and 15 short straights (6.6m) for insertion devices. In the baseline lattice, the short straights have small horizontal and vertical beta functions but the long straights have large horizontal beta function optimized for injection. In this paper, we explore the possibility of maintaining three long straights with large horizontal beta function while providing the other 12 long straights with smaller horizontal beta function to optimize the brightness of insertion devices. Our study considers the possible linear lattice solutions as well as characterizing the nonlinear dynamics. Results are reported on optimization of dynamic aperture required for good injection efficiency and adequate Touschek lifetime. This paper discusses dynamic aperture optimization for the NSLS-II lattice with alternate high and low horizontal beta function in the long straights, which is proposed for the optimization of the brightness of insertion devices. The linear optics is optimized to meet the requirements of lattice function and source properties. Nonlinear optimization for a lattice with working point at (37.18, 16.2) is performed. Considering the realistic magnets errors and physical apertures, we calculate the frequency maps and plot the tune footprint. The results show that the lattice with high-low beta function has adequate dynamic aperture for good injection efficiency and sufficient Touschek lifetime.

  14. Ratcheting failure of pressurised straight pipes and elbows under reversed bending

    International Nuclear Information System (INIS)

    Vishnuvardhan, S.; Raghava, G.; Gandhi, P.; Saravanan, M.; Goyal, Sumit; Arora, Punit; Gupta, Suneel K.; Bhasin, Vivek

    2013-01-01

    Ratcheting studies were carried out on Type 304LN stainless steel straight pipes and elbows subjected to steady internal pressure and cyclic bending load. The internal pressure for all the straight pipes was 35 MPa and in the case of elbows the internal pressure was varied for different elbows, ranging from 27.6 MPa to 39.2 MPa. Cyclic bending load was applied on the specimens by subjecting them to different levels of load-line displacement. The specimens have undergone significant ratchet swelling (ballooning), ovalization and consequent thinning of the cross-section during ratcheting. The straight pipes failed either by occurrence of through-wall crack accompanied by simultaneous ballooning, or bursting with simultaneous ballooning. All the elbows failed by occurrence of through-wall crack accompanied by simultaneous ballooning. Ratcheting behaviour of straight pipes and elbows were compared and it was generally inferred that ratcheting was more pronounced in straight pipes than in elbows. -- Graphical abstract: Strain history for the specimen QCE-RAT-6-L1. Highlights: • Studies were carried out under combined internal pressure and cyclic bending. • Ratcheting strains were measured at critical locations of the specimens. • Quantified the percentage of ballooning, ovalization and reduction in thickness. • Modes of ratcheting failure of straight pipes and elbows are studied. • Inferred that ratcheting is more pronounced in straight pipes than in elbows

  15. Statistics of hits to bone cell nuclei

    International Nuclear Information System (INIS)

    Kruglikov, I.L.; Polig, E.; Jee, W.S.S.

    1993-01-01

    The statistics of hits to the nuclei of bone cells irradiated from alpha sources labeling bone tissue is described. It is shown that the law of remodeling of a bone structural unit (BSU), which describes the distribution of quiescence periodes of this unit, affects the statistics of hits. It the irradiation of bone cells occurs during the whole cell cycle, the mean number of hits is independent of the law of remodeling. In this case the variance of hits has the minimum value for constant quiescence periods of BSUs (deterministic remodeling) and the maximum value for exponentially distributed quiescence periods (random remodeling). For the first generation of bone cells, i.e. for the cells which existed at the moment of the uptake of the nuclide, the mean number of hits depends on the law of remodeling. For random remodeling the mean number is equal to the mean value for the complete remodeling cycle. For deterministic remodeling the mean is only half this value. For the first generation of bone cells, changing the law of remodeling from random to deterministic increases the probability of no hits to the nuclei of bone cells. For the same mean value of hits, the difference does not exceed 13.3% of the total number of cells. For the subsequent generations of bone cells, such a change of the law of remodeling decreases the probability of no hits up to 20.4% of the total number of cells. (orig.)

  16. First straw straightness measurements on a 4-plane end-cap ATLAS TRT wheel

    CERN Document Server

    Lucotte, A; Mitsou, V A; Mouraviev, S V; Nadtochy, A

    2001-01-01

    This document reports the first results and their interpretation of the straw straightness measurements that have been performed on the first 4-plane end-cap prototype of the ATLAS TRT. Section 2 presents the experimental setup used for the measurements, as well as a review of the data sample used to perform this study. It also provides a description of the method used to assess straw straightness, which is based on the measurements of the maximal gas gain deviation (``straw eccentricity'') seen along the straw. Section 3 reports the results of straw straightness for the 4-plane module, including corrections due to the gas flow. The effect of energy resolution degradation is also explained and results in terms of wire offset are reported. In Section 4, the straw bending due to an applied lateral deformation is measured, and finally Section 5 reviews the conclusions.

  17. Straight line closure of congenital macrostomia

    Directory of Open Access Journals (Sweden)

    Schwarz Richard

    2004-01-01

    Full Text Available The results of patients operated on by Nepal Cleft Lip and Palate Association (NECLAPA surgeons for congenital macrostomia were prospectively studied between January 2000 and December 2002. There were four males and three females with a median age of 10 years. Three had an associated branchial arch syndrome. In all patients an overlapping repair of orbicularis oris was done. Six patients had a straight line closure with excellent cosmetic results and one a Z-plasty with a more obvious scar. All had a normal appearing commissure. Overlapping orbicularis repair with straight line skin closure for this rare congenital anomaly is recommended.

  18. Constructive Technology Assessment for HIT development

    DEFF Research Database (Denmark)

    Høstgaard, Anna Marie Balling; Bertelsen, Pernille; Petersen, Lone Stub

    2013-01-01

    Experience and time has shown a need for new evaluation methods for evaluating Health Information Technology (HIT), as summative evaluation methods fail to accommodate the rapid and constant changes in HIT over time and to involve end-users, which has been recognized as an important success facto...... during all the phases in the process. Thereby anumber of problems were prevented to occur later on.Thus, the CTA method and its framework are useful for evaluators and project-management in order to facilitate and support successful HIT development....

  19. An intersection graph of straight lines

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2002-01-01

    G. Ehrlich, S. Even, and R.E. Tarjan conjectured that the graph obtained from a complete 3 partite graph K4,4,4 by deleting the edges of four disjoint triangles is not the intersection graph of straight line segments in the plane. We show that it is....

  20. The validation of Huffaz Intelligence Test (HIT)

    Science.gov (United States)

    Rahim, Mohd Azrin Mohammad; Ahmad, Tahir; Awang, Siti Rahmah; Safar, Ajmain

    2017-08-01

    In general, a hafiz who can memorize the Quran has many specialties especially in respect to their academic performances. In this study, the theory of multiple intelligences introduced by Howard Gardner is embedded in a developed psychometric instrument, namely Huffaz Intelligence Test (HIT). This paper presents the validation and the reliability of HIT of some tahfiz students in Malaysia Islamic schools. A pilot study was conducted involving 87 huffaz who were randomly selected to answer the items in HIT. The analysis method used includes Partial Least Square (PLS) on reliability, convergence and discriminant validation. The study has validated nine intelligences. The findings also indicated that the composite reliabilities for the nine types of intelligences are greater than 0.8. Thus, the HIT is a valid and reliable instrument to measure the multiple intelligences among huffaz.

  1. A fast online hit verification method for the single ion hit system at GSI

    International Nuclear Information System (INIS)

    Du, G.; Fischer, B.; Barberet, P.; Heiss, M.

    2006-01-01

    For a single ion hit facility built to irradiate specific targets inside biological cells, it is necessary to prove that the ions hit the selected targets reliably because the ion hits usually cannot be seen. That ability is traditionally tested either indirectly by aiming at pre-etched tracks in a nuclear track detector or directly by making the ion tracks inside cells visible using a stain coupled to special proteins produced in response to ion hits. However, both methods are time consuming and hits can be verified only after the experiment. This means that targeting errors in the experiment cannot be corrected during the experiment. Therefore, we have developed a fast online hit verification method that measures the targeting accuracy electronically with a spatial resolution of ±1 μm before cell irradiation takes place. (authors)

  2. How I treat double-hit lymphoma.

    Science.gov (United States)

    Friedberg, Jonathan W

    2017-08-03

    The 2016 revision of the World Health Organization (WHO) classification for lymphoma has included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc and bcl-2 or bcl-6 . These lymphomas, which occur in hit lymphomas (or triple-hit lymphomas if all 3 rearrangements are present). It is important to differentiate these lymphomas from the larger group of double-expressor lymphomas, which have increased expression of MYC and BCL-2 and/or BCL-6 by immunohistochemistry, by using variable cutoff percentages to define positivity. Patients with double-hit lymphomas have a poor prognosis when treated with standard chemoimmunotherapy and have increased risk of central nervous system involvement and progression. Double-hit lymphomas may arise as a consequence of the transformation of the underlying indolent lymphoma. There are no published prospective trials in double-hit lymphoma, however retrospective studies strongly suggest that aggressive induction regimens may confer a superior outcome. In this article, I review my approach to the evaluation and treatment of double-hit lymphoma, with an eye toward future clinical trials incorporating rational targeted agents into the therapeutic armamentarium. © 2017 by The American Society of Hematology.

  3. Throat hit in users of the electronic cigarette: An exploratory study.

    Science.gov (United States)

    Etter, Jean-François

    2016-02-01

    A cross-sectional survey on the Internet in 2012-2014 was used to study the "throat hit," the specific sensation in the throat felt by users of e-cigarettes. Participants were 1672 current users of e-cigarettes, visitors of Websites dedicated to e-cigarettes and to smoking cessation. It was assessed whether the strength of the throat hit was associated with the characteristics of e-cigarettes and e-liquids, modifications of the devices, patterns of use, reasons for use, satisfaction with e-cigarettes, dependence on e-cigarettes, smoking behavior, and perceived effects on smoking. The strongest throat hit was obtained by using better-quality models and liquids with high nicotine content. Those who reported a "very strong" throat hit used liquids with 17.3 mg/mL nicotine, versus 7.1 mg/mL for those reporting a "very weak" hit (p e-cigarette models that provide high levels of nicotine, a strong throat hit, high satisfaction, and more effects on smoking, but may also be addictive, and models than contain less nicotine and are less addictive, but produce a weaker throat hit, are less satisfactory, and are possibly less efficient at helping people quit smoking. This trade-off must be kept in mind when regulating e-cigarettes. (c) 2016 APA, all rights reserved).

  4. Additional Quadrupoles At Center Of Long Straights In The NSLS-II Lattice

    International Nuclear Information System (INIS)

    Lin, F.; Bengtsson, J.; Guo, W.; Krinsky, S.; Li, Y.; Yang, L.

    2011-01-01

    The NSLS-II storage ring lattice is comprised of 30 DBA cells arranged in 15 superperiods. There are 15 long straight sections (9.3m) for injection, RF and insertion devices and 15 shorter straights (6.6m) for insertion devices. In the baseline lattice, the short straights have small horizontal and vertical beta functions but the long straights have large horizontal beta function optimized for injection. In this paper, we explore the possibility of installing additional quadrupoles at the center of selected long straight sections in order to provide two low-beta source locations for undulators in the same straight. The required modification to the linear lattice is discussed as well as the preservation of adequate dynamic aperture required for good injection efficiency and adequate Touschek lifetime. This paper discusses the possibility of producing two low-beta source locations for optimum brightness of undulators in the long straights of NSLS-II lattice by installing additional quadrupoles at the center. The linear optics is optimized to satisfy the requirements of lattice function and properties. Nonlinear optimization for a lattice with working point at (37.16, 17.22) is performed. Considering the magnets misalignment errors and physical apertures, we calculate the frequency maps and plot the tune footprint. The results show that the modified high-low beta function lattice can achieve a modest dynamic aperture in this preliminary study. Further work will continue to expand the dynamic aperture to meet the requirement of good injection efficiency and sufficient Touschek lifetime.

  5. Straight-line string with curvature

    International Nuclear Information System (INIS)

    Solov'ev, L.D.

    1995-01-01

    Classical and quantum solutions for the relativistic straight-line string with arbitrary dependence on the world surface curvature are obtained. They differ from the case of the usual Nambu-Goto interaction by the behaviour of the Regge trajectory which in general can be non-linear. A regularization of the action is considered and a comparison with relativistic point with curvature is made. 5 refs

  6. Straight, white teeth as a social prerogative.

    Science.gov (United States)

    Khalid, Abeer; Quiñonez, Carlos

    2015-06-01

    A distinguishing feature of North American society is preoccupation with self-image, as seen in the ritualistic nature of bodily practices aimed at constantly improving the body. Nowhere is this more apparent than in the prevailing fixation with straight, white teeth. While there is an ever-expanding literature on the sociology of body, very little has been written on teeth in this context. Using literature from anthropology, biology, dentistry, sociology and social psychology, this study attempts to answer: (1) Why have straight, white teeth become a beauty ideal in North American society? (2) What is the basis for this ideal? (3) How is this ideal propagated? It demonstrates that dental aesthetic tendencies are biologically, culturally and socially patterned. Concepts from the works of Pierre Bourdieu and Michel Foucault are used to illustrate how straight, white teeth contribute towards reinforcing class differences and how society exercises a disciplinary power on individuals through this ideal. It is concluded that modified teeth are linked to self and identity that are rooted in social structure. Moreover, teeth demonstrate the ways in which class differences are embodied and projected as symbols of social advantage or disadvantage. Implications on professional, public health, sociological and political levels are considered. © 2015 Foundation for the Sociology of Health & Illness.

  7. Straight until proven gay: A systematic bias toward straight categorizations in sexual orientation judgments.

    Science.gov (United States)

    Lick, David J; Johnson, Kerri L

    2016-06-01

    Perceivers achieve above chance accuracy judging others' sexual orientations, but they also exhibit a notable response bias by categorizing most targets as straight rather than gay. Although a straight categorization bias is evident in many published reports, it has never been the focus of systematic inquiry. The current studies therefore document this bias and test the mechanisms that produce it. Studies 1-3 revealed the straight categorization bias cannot be explained entirely by perceivers' attempts to match categorizations to the number of gay targets in a stimulus set. Although perceivers were somewhat sensitive to base rate information, their tendency to categorize targets as straight persisted when they believed each target had a 50% chance of being gay (Study 1), received explicit information about the base rate of gay targets in a stimulus set (Study 2), and encountered stimulus sets with varying base rates of gay targets (Study 3). The remaining studies tested an alternate mechanism for the bias based upon perceivers' use of gender heuristics when judging sexual orientation. Specifically, Study 4 revealed the range of gendered cues compelling gay judgments is smaller than the range of gendered cues compelling straight judgments despite participants' acknowledgment of equal base rates for gay and straight targets. Study 5 highlighted perceptual experience as a cause of this imbalance: Exposing perceivers to hyper-gendered faces (e.g., masculine men) expanded the range of gendered cues compelling gay categorizations. Study 6 linked this observation to our initial studies by demonstrating that visual exposure to hyper-gendered faces reduced the magnitude of the straight categorization bias. Collectively, these studies provide systematic evidence of a response bias in sexual orientation categorization and offer new insights into the mechanisms that produce it. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  8. 21 CFR 82.5 - General specifications for straight colors.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false General specifications for straight colors. 82.5... LISTING OF CERTIFIED PROVISIONALLY LISTED COLORS AND SPECIFICATIONS General Provisions § 82.5 General specifications for straight colors. No batch of a straight color listed in subpart B, C, or D shall be certified...

  9. Straight and White: Talking with My Mouth Full

    Science.gov (United States)

    Myers, W. Benjamin

    2008-01-01

    By using straight and white teeth as a metaphor for a straight and White identity, the author reflects on how this identity is performed, maintained, and often problematic. Using literature about identity performance, three different voices speak to and from straight and White identity. Using irony by blending arrogance and ignorance in the voice…

  10. NIMROD Simulations of the HIT-SI and HIT-SI3 Devices

    Science.gov (United States)

    Morgan, Kyle; Jarboe, Tom; Hossack, Aaron; Chandra, Rian; Everson, Chris

    2017-10-01

    The Helicity Injected Torus with Steady Inductive helicity injection (HIT-SI) experiment uses a set of inductively driven helicity injectors to apply non-axisymmetric current drive on the edge of the plasma, driving an axisymmetric spheromak equilibrium in a central confinement volume. Significant improvements have been made to extended MHD modeling of HIT-SI, with both the resolution of disagreement at high injector frequencies in HIT-SI in addition to successes with the new upgraded HIT-SI3 device. Previous numerical studies of HIT-SI, using a zero-beta eMHD model, focused on operations with a drive frequency of 14.5 kHz, and found reduced agreement with both the magnetic profile and current amplification at higher frequencies (30-70 kHz). HIT-SI3 has three helicity injectors which are able to operate with different mode structures of perturbations through the different relative temporal phasing of the injectors. Simulations that allow for pressure gradients have been performed in the parameter regimes of both devices using the NIMROD code and show improved agreement with experimental results, most notably capturing the observed Shafranov-shift due to increased beta observed at higher finj in HIT-SI and the variety of toroidal perturbation spectra available in HIT-SI3. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Fusion Energy Sciences under Award Number DE-FG02- 96ER54361.

  11. Greater Engagement among Members of Gay-Straight Alliances: Individual and Structural Contributors

    Science.gov (United States)

    Poteat, V. Paul; Heck, Nicholas C.; Yoshikawa, Hirokazu; Calzo, Jerel P.

    2016-01-01

    Using youth program models to frame the study of Gay-Straight Alliances (GSAs), we identified individual and structural predictors of greater engagement in these settings with a cross-sectional sample of 295 youth in 33 GSAs from the 2014 Massachusetts GSA Network Survey (69% LGBQ, 68% cisgender female, 68% White, M[subscript age] =16.07).…

  12. Curved-straight neutron guide system with uniform spatial intensity distribution

    International Nuclear Information System (INIS)

    Mildner, D.F.R.; Cook, J.C.

    2008-01-01

    The spatial intensity distribution of neutrons emerging from a curved guide is asymmetric, and straight guide sections are sometimes appended to curved guides to make the intensity distribution more nearly uniform. For idealized uniform illumination and in the perfect reflectivity approximation, the spatial-angular acceptance at the exit of the combination can be made exactly uniform for a range of long wavelengths by using a sufficiently long straight section, together with a curved guide whose outer wall coating has a critical angle slightly greater than those of the other guide walls. We refer to this as a 'phase space tailoring guide' where the coatings on the inner wall and straight section are used to define the required divergence at the end of the guide. Increasing the critical angle of the outer wall of the curved section reduces the characteristic wavelength of the curved guide as well as the wavelength at which ideal uniformity can be obtained. The outer wall coating need only be of sufficiently high critical angle to fill the transmittable phase space area of the straight guide uniformly to adequately short wavelength

  13. Synthesis and characterization of straight and stacked-sheet AlN nanowires with high purity

    International Nuclear Information System (INIS)

    Lei, M.; Yang, H.; Li, P.G.; Tang, W.H.

    2008-01-01

    Large-scale AlN nanowires with hexagonal crystal structure were synthesized by the direct nitridation method at high temperatures. The experimental results indicate that these single-crystalline AlN nanowires have high purity and consist of straight and stacked-sheet nanowires. It is found that straight AlN nanowire grows along [1, 1, -2, 0] direction, whereas the stacked-sheet nanowire with hexagonal cross section is along [0 0 0 1] direction. It is thought that vapor-solid (VS) mechanism should be responsible for the growth of AlN nanowires

  14. Subjective Straight Ahead Orientation in Microgravity

    Science.gov (United States)

    Clement, G.; Reschke, M. F.; Wood, S. J.

    2015-01-01

    This joint ESA NASA study will address adaptive changes in spatial orientation related to the subjective straight ahead and the use of a vibrotactile sensory aid to reduce perceptual errors. The study will be conducted before and after long-duration expeditions to the International Space Station (ISS) to examine how spatial processing of target location is altered following exposure to microgravity. This study addresses the sensorimotor research gap to "determine the changes in sensorimotor function over the course of a mission and during recovery after landing."

  15. Straight Vegetable Oil as a Diesel Fuel?

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-01-01

    Biodiesel, a renewable fuel produced from animal fats or vegetable oils, is popular among many vehicle owners and fleet managers seeking to reduce emissions and support U.S. energy security. Questions sometimes arise about the viability of fueling vehicles with straight vegetable oil (SVO), or waste oils from cooking and other processes, without intermediate processing. But SVO and waste oils differ from biodiesel (and conventional diesel) in some important ways and are generally not considered acceptable vehicle fuels for large-scale or long-term use.

  16. Statistical properties and pre-hit dynamics of price limit hits in the Chinese stock markets.

    Science.gov (United States)

    Wan, Yu-Lei; Xie, Wen-Jie; Gu, Gao-Feng; Jiang, Zhi-Qiang; Chen, Wei; Xiong, Xiong; Zhang, Wei; Zhou, Wei-Xing

    2015-01-01

    Price limit trading rules are adopted in some stock markets (especially emerging markets) trying to cool off traders' short-term trading mania on individual stocks and increase market efficiency. Under such a microstructure, stocks may hit their up-limits and down-limits from time to time. However, the behaviors of price limit hits are not well studied partially due to the fact that main stock markets such as the US markets and most European markets do not set price limits. Here, we perform detailed analyses of the high-frequency data of all A-share common stocks traded on the Shanghai Stock Exchange and the Shenzhen Stock Exchange from 2000 to 2011 to investigate the statistical properties of price limit hits and the dynamical evolution of several important financial variables before stock price hits its limits. We compare the properties of up-limit hits and down-limit hits. We also divide the whole period into three bullish periods and three bearish periods to unveil possible differences during bullish and bearish market states. To uncover the impacts of stock capitalization on price limit hits, we partition all stocks into six portfolios according to their capitalizations on different trading days. We find that the price limit trading rule has a cooling-off effect (object to the magnet effect), indicating that the rule takes effect in the Chinese stock markets. We find that price continuation is much more likely to occur than price reversal on the next trading day after a limit-hitting day, especially for down-limit hits, which has potential practical values for market practitioners.

  17. Statistical Properties and Pre-Hit Dynamics of Price Limit Hits in the Chinese Stock Markets

    Science.gov (United States)

    Wan, Yu-Lei; Xie, Wen-Jie; Gu, Gao-Feng; Jiang, Zhi-Qiang; Chen, Wei; Xiong, Xiong; Zhang, Wei; Zhou, Wei-Xing

    2015-01-01

    Price limit trading rules are adopted in some stock markets (especially emerging markets) trying to cool off traders’ short-term trading mania on individual stocks and increase market efficiency. Under such a microstructure, stocks may hit their up-limits and down-limits from time to time. However, the behaviors of price limit hits are not well studied partially due to the fact that main stock markets such as the US markets and most European markets do not set price limits. Here, we perform detailed analyses of the high-frequency data of all A-share common stocks traded on the Shanghai Stock Exchange and the Shenzhen Stock Exchange from 2000 to 2011 to investigate the statistical properties of price limit hits and the dynamical evolution of several important financial variables before stock price hits its limits. We compare the properties of up-limit hits and down-limit hits. We also divide the whole period into three bullish periods and three bearish periods to unveil possible differences during bullish and bearish market states. To uncover the impacts of stock capitalization on price limit hits, we partition all stocks into six portfolios according to their capitalizations on different trading days. We find that the price limit trading rule has a cooling-off effect (object to the magnet effect), indicating that the rule takes effect in the Chinese stock markets. We find that price continuation is much more likely to occur than price reversal on the next trading day after a limit-hitting day, especially for down-limit hits, which has potential practical values for market practitioners. PMID:25874716

  18. Roundness and straightness measurement of ceramic beam ducts for the 3 GeV-synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Nishizawa, Daiji; Kinsho, Michikazu; Kanazawa, Kenichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kubo, Tomio; Sato, Yoshihiro; Saito, Yoshio [High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan)

    2001-12-01

    Large aperture ({phi}200 - {phi}250) cylindrical beam ducts consisting of alumina ceramics will be used in the 3 GeV-synchrotron of High Intensity Proton Accelerator Facility. In particular, bending magnet sections require the large length ({approx}3500 mm) ceramic beam duct connecting several unit ducts whose length is around 500-1000 mm by metallizing and glazing. Therefore it is very important to evaluate roundness and straightness of ceramic ducts because we have to compensate contact area large and have to minimize misalignment of ducts connected. We developed an apparatus for measuring roundness and straightness, and we completed data analysis method using general application software Excel as well as measuring method. Then we have taken data, and have evaluated value of roundness and straightness for the first time about 7 pieces (3 kinds) of ceramic beam duct. At last we have found out that unit ceramic ducts can be made after sintering without polishing with roundness several hundred micron ({mu}m) and straightness around 0.2-1 mm, and that straightness has a tendency to become large as duct length increases as well as roundness increases directly proportional to the maximum oblateness. (author)

  19. Upgrade tracking with the UT Hits

    CERN Document Server

    Gandini, P; Wang, J

    2014-01-01

    The performance of the LHCb tracking system for the upgrade on long tracks is evaluated in terms of efficiency and ghost rate reduction for several different sets of requirements. We find that the efficiency is quite high and that the ghost rate reduction is substantial. We also describe the current algorithm for adding UT hits to the tracks.

  20. Double-hit B-cell lymphomas

    NARCIS (Netherlands)

    Aukema, Sietse M.; Siebert, Reiner; Schuuring, Ed; van Imhoff, Gustaaf W.; Kluin-Nelemans, Hanneke C.; Boerma, Evert-Jan; Kluin, Philip M.

    2011-01-01

    In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double-hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint,

  1. A combined hit theory-microdosimetric explanation of cellular radiobiological action

    International Nuclear Information System (INIS)

    Bond, V.P.; Varma, M.N.

    1983-01-01

    Hit theory is combined with microdosimetry in a stochastic approach that explains the observed responses of cell populations exposed in radiation fields of different qualities. The central thesis is that to expose a population of cells in a low-level radiation field is to subject the cells to the potential for interaction with charged particles, quantifiable in terms of the charged particle fluence PHI. When such an interaction occurs there is resulting stochastic transfer of energy to a critical volume (CV) of cross-section σ within the cell(s). The severity of cell injury is dependent on the amount of energy thus imparted, or the hit size. If the severity is above some minimal level, there is a non-zero probability that the injury will result in a quantal effect (e.g., a mutational or carcinogenic initial event, cell transformation). A microdosimetric proportional counter, viewed here as a phantom cell CV that permits measurements not possible in the living cell, is used to determine the incidence of hit cells and the spectrum of hit sizes. Each hit is then weighted on the basis of an empirically determined function that provides the fraction of cells responding quantally, as a function of hit size. The sum of the hits so weighted provides the incidence of quantally responding cells, for any amount of exposure PHI in a radiation field of any quality or mixture of qualities. The hit size weighting function for pink mutations in Tradescantia is discussed, as are its implications in terms of a replacement for relative biological effectiveness and dose equivalent. (author)

  2. Hit the gas: go green!

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Just one year ago, CERN took delivery of its first bi-fuel vehicles (see article in Bulletin 07-08/2011). Today, the fleet comprises 100 vehicles capable of running with petrol or natural gas. At that time, Véronique Marchal, head of the Site Services section in the GS Department, told us: “We are counting on CERN car users’ environmental awareness to use natural gas fuel whenever possible.” Observations one year later show that... well, let’s say there is still plenty of room for improvement. A new awareness campaign has therefore been launched.   “Running on natural gas reduces carbon dioxide emissions by some 40%,” explains Serge Micallef of the Services Industriels de Genève (SIG), CERN’s partners for this green mobility project. CNG contains 20% biogas, which is carbon-neutral. CNG produces 60 to 95% less pollution overall than ordinary petrol, and it is entirely soot-free. It is true that filli...

  3. Isolated orbital mass as the primary presentation of a triple-hit lymphoma transformed from a systemic follicular lymphoma.

    Science.gov (United States)

    Zhou, Xiao Yi; Lu, Xinyan; Raparia, Kirtee; Chen, Yi-Hua

    2018-06-01

    Triple-hit lymphoma is a highly aggressive B-cell lymphoma. We report a case of triple-hit lymphoma transformed from systemic follicular lymphoma (FL) after 9-year remission and presented primarily as an isolated orbital mass without systemic symptoms or lymphadenopathy. A 58-year-old female presented with intermittent vertical binocular diplopia, left upper eyelid swelling and pain and was found to have a 2.9 cm orbital mass. Histological section revealed a CD10-positive large B-cell lymphoma, consistent with transformation of FL. Fluorescent in situ hybridization (FISH) analysis demonstrated rearrangements involving C-MYC, BCL-2 and BCL-6 genes, indicating a high grade, triple-hit lymphoma. Triple-hit lymphoma transformed from a low-grade lymphoma may initially present as an isolated orbital mass without systemic evidence of transformation. Early recognition of double or triple-hit lymphomas is important since these patients require aggressive chemotherapy.

  4. Lateral convection and diffusion of sediment in straight rivers

    DEFF Research Database (Denmark)

    Christensen, Henrik Bo; Fredsøe, Jørgen

    1998-01-01

    and a higher level of turbulence at the channel centre, than in the near bank zones, which means that the ability to support suspended sediment will decrease from the channel centre. The two turbulence models give different estimates for the lateral transport, which mainly are caused by turbulence generated......The lateral transport of suspended sediment in a straight river cross section with a parabolic shaped bed is studied be use of a k-e and a full Reynolds stress turbulence model. Due to depth variations a lateral transport of suspended sediment is generated. This is mainly caused by the slopping bed...... secondary flow cells in the Reynolds stress model. The flow cells make zones with alternately high and low sediment concentration, and thereby much higher local gradients in the lateral direction. Both models found a net inward lateral transport. The transport by convection was found more dominant than...

  5. Post-hit dynamics of price limit hits in the Chinese stock markets

    Science.gov (United States)

    Wu, Ting; Wang, Yue; Li, Ming-Xia

    2017-01-01

    Price limit trading rules are useful to cool off traders short-term trading mania on individual stocks. The price dynamics approaching the limit boards are known as the magnet effect. However, the price dynamics after opening price limit hits are not well investigated. Here, we provide a detailed analysis on the price dynamics after the hits of up-limit or down-limit is open based on all A-share stocks traded in the Chinese stock markets. A "W" shape is found in the expected return, which reveals high probability of a continuous price limit hit on the following day. We also find that price dynamics after opening limit hits are dependent on the market trends. The time span of continuously hitting the price limit is found to an influence factor of the expected profit after the limit hit is open. Our analysis provides a better understanding of the price dynamics around the limit boards and contributes potential practical values for investors.

  6. Attitudes toward straight, gay male, and transsexual parenting.

    Science.gov (United States)

    Weiner, Brittany A; Zinner, Leah

    2015-01-01

    This study examined American attitudes toward transsexual and gay male parenting, compared to straight parenting. After reporting levels of transphobia, participants read a vignette regarding a couple seeking child adoption. Individuals high in transphobia perceived nontraditional couples as more emotionally unstable than straight couples and were less willing to grant custody of a child to the nontraditional couples vs. the straight couples. In addition, the transsexual couple faced more prejudice and discrimination than the gay male couple. Implications of these findings are discussed.

  7. Free-boundary stability of straight stellarators

    International Nuclear Information System (INIS)

    Barnes, D.C.; Cary, J.R.

    1984-02-01

    The sharp-boundary model is used to investigate the stability of straight stellarators to free-boundary, long-wavelength modes. To correctly analyze the heliac configuration, previous theory is generalized to the case of arbitrary helical aspect ratio (ratio of plasma radius to periodicity lengths). A simple low-β criterion involving the vacuum field and the normalized axial current is derived and used to investigate a large variety of configurations. The predictions of this low-β theory are verified by numerical minimization of deltaW at arbitrary β. The heliac configuration is found to be remarkably stable, with a critical β of over 15% determined by the lack of equilibrium rather than the onset of instability. In addition, other previously studied systems are found to be stabilized by net axial plasma current

  8. A straightness error measurement method matched new generation GPS

    International Nuclear Information System (INIS)

    Zhang, X B; Lu, H; Jiang, X Q; Li, Z

    2005-01-01

    The axis of the non-diffracting beam produced by an axicon is very stable and can be adopted as the datum line to measure the spatial straightness error in continuous working distance, which may be short, medium or long. Though combining the non-diffracting beam datum-line with LVDT displace detector, a new straightness error measurement method is developed. Because the non-diffracting beam datum-line amends the straightness error gauged by LVDT, the straightness error is reliable and this method is matchs new generation GPS

  9. On the Hitting Probability of Max-Stable Processes

    OpenAIRE

    Hofmann, Martin

    2012-01-01

    The probability that a max-stable process {\\eta} in C[0, 1] with identical marginal distribution function F hits x \\in R with 0 < F (x) < 1 is the hitting probability of x. We show that the hitting probability is always positive, unless the components of {\\eta} are completely dependent. Moreover, we consider the event that the paths of standard MSP hit some x \\in R twice and we give a sufficient condition for a positive probability of this event.

  10. Simplified validation of borderline hits of database searches

    OpenAIRE

    Thomas, Henrik; Shevchenko, Andrej

    2008-01-01

    Along with unequivocal hits produced by matching multiple MS/MS spectra to database sequences, LC-MS/MS analysis often yields a large number of hits of borderline statistical confidence. To simplify their validation, we propose to use rapid de novo interpretation of all acquired MS/MS spectra and, with the help of a simple software tool, display the candidate sequences together with each database search hit. We demonstrate that comparing hit database sequences and independent de novo interpre...

  11. 78 FR 29135 - HIT Standards Committee Advisory Meeting

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting AGENCY: Office of...: HIT Standards Committee. General Function of the Committee: To provide recommendations to the National... Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT Policy Committee...

  12. Cosmic Ray Hit Detection with Homogenous Structures

    Science.gov (United States)

    Smirnov, O. M.

    Cosmic ray (CR) hits can affect a significant number of pixels both on long-exposure ground-based CCD observations and on the Space Telescope frames. Thus, methods of identifying the damaged pixels are an important part of the data preprocessing for practically any application. The paper presents an implementation of a CR hit detection algorithm based on a homogenous structure (also called cellular automata ), a concept originating in artificial intelligence and dicrete mathematics. Each pixel of the image is represented by a small automaton, which interacts with its neighbors and assumes a distinct state if it ``decides'' that a CR hit is present. On test data, the algorithm has shown a high detection rate (~0.7 ) and a low false alarm rate (frame. A homogenous structure is extremely trainable, which can be very important for processing large batches of data obtained under similar conditions. Training and optimizing issues are discussed, as well as possible other applications of this concept to image processing.

  13. All hypertopologies are hit-and-miss

    Directory of Open Access Journals (Sweden)

    Somshekhar Naimpally

    2002-04-01

    Full Text Available We solve a long standing problem by showing that all known hypertopologies are hit-and-miss. Our solution is not merely of theoretical importance. This representation is useful in the study of comparison of the Hausdorff-Bourbaki or H-B uniform topologies and the Wijsman topologies among themselves and with others. Up to now some of these comparisons needed intricate manipulations. The H-B uniform topologies were the subject of intense activity in the 1960's in connection with the Isbell-Smith problem. We show that they are proximally locally finite topologies from which the solution to the above problem follows easily. It is known that the Wijsman topology on the hyperspace is the proximal ball (hit-and-miss topology in”nice” metric spaces including the normed linear spaces. With the introduction of a new far-miss topology we show that the Wijsman topology is hit-and-miss for all metric spaces. From this follows a natural generalization of the Wijsman topology to the hyperspace of any T1 space. Several existing results in the literature are easy consequences of our work.

  14. The accelerator facility of the Heidelberg Ion-Beam Therapy Centre (HIT)

    Science.gov (United States)

    Peters, Andreas

    The following sections are included: * Introduction * Beam parameters * General layout of the HIT facility * The accelerator chain in detail * Operational aspects of a particle therapy facility * 24/7 accelerator operation at 335 days per year * Safety and regulatory aspects * Status and perspectives * References

  15. 26 CFR 1.9001-1 - Change from retirement to straight-line method of computing depreciation.

    Science.gov (United States)

    2010-04-01

    ... of computing depreciation. 1.9001-1 Section 1.9001-1 Internal Revenue INTERNAL REVENUE SERVICE....9001-1 Change from retirement to straight-line method of computing depreciation. (a) In general. The... of deductions for the depreciation of those roadway assets which are defined in this section as...

  16. Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis.

    Science.gov (United States)

    Padmanabhan, Anand; Jones, Curtis G; Bougie, Daniel W; Curtis, Brian R; McFarland, Janice G; Wang, Demin; Aster, Richard H

    2015-01-01

    Antibodies specific for platelet factor 4 (PF4)/heparin complexes are the hallmark of heparin-induced thrombocytopenia and thrombosis (HIT), but many antibody-positive patients have normal platelet counts. The basis for this is not fully understood, but it is believed that antibodies testing positive in the serotonin release assay (SRA) are the most likely to cause disease. We addressed this issue by characterizing PF4-dependent binding of HIT antibodies to intact platelets and found that most antibodies testing positive in the SRA, but none of those testing negative, bind to and activate platelets when PF4 is present without any requirement for heparin (P HIT antibodies recognize PF4 in a complex with heparin, only a subset of these antibodies recognize more subtle epitopes induced in PF4 when it binds to CS, the major platelet glycosaminoglycan. Antibodies having this property could explain "delayed HIT" seen in some individuals after discontinuation of heparin and the high risk for thrombosis that persists for weeks in patients recovered from HIT. © 2015 by The American Society of Hematology.

  17. Eyewitness Identification Reforms: Are Suggestiveness-Induced Hits and Guesses True Hits?

    Science.gov (United States)

    Wells, Gary L; Steblay, Nancy K; Dysart, Jennifer E

    2012-05-01

    Research-based reforms for collecting eyewitness identification evidence (e.g., unbiased pre-lineup instructions, double-blind administration) have been proposed by psychologists and adopted in increasing numbers of jurisdictions across the United States. It is well known that reducing rates of mistaken identifications can also reduce accurate identification rates (hits). But the reforms are largely designed to reduce the suggestiveness of the procedures they are meant to replace. Accordingly, we argue that it is misleading to label any hits obtained because of suggestive procedures as "hits" and then saddle reforms with the charge that they reduce the rate of these illegitimate hits. Eyewitness identification evidence should be based solely on the independent memory of the witness, not aided by biased instructions, cues from lineup administrators, or the use of lineup fillers who make the suspect stand out. Failure to call out these hits as being illegitimate can give solace to those who are motivated to preserve the status quo. © The Author(s) 2012.

  18. Stigma and Stigma by Association in Perceptions of Straight Allies

    Science.gov (United States)

    Goldstein, Susan B.

    2017-01-01

    As evidence builds for straight allies' contributions to battling sexual prejudice, barriers to assuming this role must be identified and dismantled. This study investigated stigma and stigma by association in perceptions of straight allies in a college population. Adjective rating items were completed by 505 participants who identified as…

  19. Setting the Record Straight. The Truth About Fad Diets.

    Science.gov (United States)

    Wheat Foods Council, Parker, CO.

    The Setting the Record Straight information packet presents facts to set the record straight about nutrition and debunk fad diets. The kit features materials designed to communicate the importance of balanced eating. Materials include: a time line of fad diets; four reproducible fad diet book review handouts that show the misleading claims rampant…

  20. Spider diffraction: a comparison of curved and straight legs

    International Nuclear Information System (INIS)

    Richter, J.L.

    1984-01-01

    It has been known for some time that, if curved legs rather than the usual straight ones are used in the spider that supports the secondary optics in certain telescopes, the visible diffraction effect is reduced. Fraunhofer theory is used to calculate the diffraction effects due to the curved leg spider. Calculated and photographic diffraction patterns are compared for straight and curved leg spiders

  1. Health information technology knowledge and skills needed by HIT employers.

    Science.gov (United States)

    Fenton, S H; Gongora-Ferraez, M J; Joost, E

    2012-01-01

    To evaluate the health information technology (HIT) workforce knowledge and skills needed by HIT employers. Statewide face-to-face and online focus groups of identified HIT employer groups in Austin, Brownsville, College Station, Dallas, El Paso, Houston, Lubbock, San Antonio, and webinars for rural health and nursing informatics. HIT employers reported needing an HIT workforce with diverse knowledge and skills ranging from basic to advanced, while covering information technology, privacy and security, clinical practice, needs assessment, contract negotiation, and many other areas. Consistent themes were that employees needed to be able to learn on the job and must possess the ability to think critically and problem solve. Many employers wanted persons with technical skills, yet also the knowledge and understanding of healthcare operations. The HIT employer focus groups provided valuable insight into employee skills needed in this fast-growing field. Additionally, this information will be utilized to develop a statewide HIT workforce needs assessment survey.

  2. Scintillation investigation of the straight back syndrome

    International Nuclear Information System (INIS)

    Ebaid, M.; Serro Azul, L.G.; Kedor, H-H.; Papaleo Netto, M.; Mignone, C.A.; Carvalho, N. de

    1976-01-01

    Scintigraphic study of the lungs was undertaken in 17 patients with the straight back syndrome divided in three groups: I. mild form; II. moderate form and III. severe form. The results showed that: a) there is a decreased flow through the pulmonary arteries; b) bilateral morphological alterations are most common (64.6%); c) the compression of the chest cause an increased cardiac silhouette in groups II (22.2%) and III (50%) besides widening of the mediastinum in all groups (25%, 44.4% and 75%, respectively); d. functional restriction is moderate in 61.5% and severe in 38.4% of the patients in the first two groups; in group III, moderate restriction is observed in 75% of the patients and severe restriction in 25%. Results indicate that the alterations observed in the scintigraphic study of the strainght back syndrome are caused by the effects of the deformed chest on the arterial perfusion of the lung. However, the severity of the anomaly and the decrease in the pulmonary circulation could not be correlated statistically [pt

  3. Hype, Hope, and Hit in Movies

    DEFF Research Database (Denmark)

    Dholakia, Nikhilesh; Turcan, Romeo V.

    2012-01-01

    This paper is part of an ongoing project to develop an interdisciplinary metatheory of bubbles, relevant to the contemporary era of globalization and rapid, technology-aided communication flows. Just in the first few years of the 21st century, several bubbles have appeared – the so-called dotcom ...... cultural field where relatively small bubbles may form. Movies represent a good arena to examine cultural bubbles on a scale that is not daunting, and where the hype-hope-hit dynamics can be observed more frequently than in most other settings....

  4. A new scheme for critical current measurements on straight superconducting cables in a large solenoid

    International Nuclear Information System (INIS)

    Rossi, L.; Volpini, G.

    1991-01-01

    The precision of I c measurement of straight superconducting cables in solenoids can be limited by the magnetic field inhomogeneity. A solution in order to improve the field homogeneity based on iron shims is presented here. A conceptual design for the experimental lay-out of a test station to be used in connection with the SOLEMI-I solenoid at the Milan INFN Section (LASA Laboratory) is given

  5. Paired Straight Hearth Furnace - Transformational Ironmaking Process

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Wei-Kao [McMaster Univ., Hamilton, ON (Canada); Debski, Paul [Andritz Metals Inc.,Canonsburg, PA (United States)

    2014-11-19

    The U. S. steel industry has reduced its energy intensity per ton of steel shipped by 33% since 1990. However, further significant gains in energy efficiency will require the development of new, transformational iron and steelmaking processes. The Paired Straight Hearth Furnace (PSH) process is an emerging alternative high productivity, direct reduced iron (DRI) technology that may achieve very low fuel rates and has the potential to replace blast furnace ironmaking. The PSH furnace can operate independently or may be coupled with other melting technologies to produce liquid hot metal that is both similar to blast furnace iron and suitable as a feedstock for basic oxygen steelmaking furnaces. The PSH process uses non-metallurgical coal as a reductant to convert iron oxides such as iron ore and steelmaking by-product oxides to DRI pellets. In this process, a multi-layer, nominally 120mm tall bed of composite “green balls” made from oxide, coal and binder is built up and contained within a moving refractory hearth. The pellet bed absorbs radiant heat energy during exposure to the high temperature interior refractory surfaces of the PSH while generating a strongly reducing gas atmosphere in the bed that yields a highly metalized DRI product. The PSH concept has been well tested in static hearth experiments. A moving bed design is being developed. The process developers believe that if successful, the PSH process has the potential to replace blast furnaces and coke ovens at a fraction of the operating and capital cost while using about 30% less energy relative to current blast furnace technology. DRI output could also feed electric arc furnaces (EAFs) by displacing a portion of the scrap charge.

  6. The Rock that Hit New York

    Energy Technology Data Exchange (ETDEWEB)

    Meade, Roger Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Keksis, August Lawrence [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-03

    On January 12, 1975, a rock seemed to fall from the sky over New York State’s Schoharie County hitting the tractor of a local farmer, who was “preparing his fields for spring planting.” As the farmer later described the event to a reporter from the UFO INVESTIGATOR, the object glanced off the tractor, fell to the ground, and melted its way through a patch of ice that was two and one half inches thick. The farmer, Leonard Tillapaugh, called the county sheriff, Harvey Stoddard, who recovered the rock, noting that it “was still warm.” Why and how a sample of the rock came to Los Alamos is not known. However, it captivated a wide Laboratory audience, was subjected to rigorous testing and evaluation. Los Alamos used the scientific method in the manner promoted by Hynek. Did Los Alamos solve the mystery of the rock’s origin? Not definitively. Although the exact origin could not be determined, it was shown conclusively that the rock was not from outer space. With that said, the saga of Rock that hit New York came to an end. Nothing more was said or written about it. The principals involved have long since passed from the scene. The NICAP ceased operations in 1980. And, the rock, itself, has disappeared.

  7. Head and pelvic movement asymmetry during lungeing in horses with symmetrical movement on the straight.

    Science.gov (United States)

    Rhodin, M; Roepstorff, L; French, A; Keegan, K G; Pfau, T; Egenvall, A

    2016-05-01

    Lungeing is commonly used as part of standard lameness examinations in horses. Knowledge of how lungeing influences motion symmetry in sound horses is needed. The aim of this study was to objectively evaluate the symmetry of vertical head and pelvic motion during lungeing in a large number of horses with symmetric motion during straight line evaluation. Cross-sectional prospective study. A pool of 201 riding horses, all functioning well and considered sound by their owners, were evaluated in trot on a straight line and during lungeing to the left and right. From this pool, horses with symmetric vertical head and pelvic movement during the straight line trot (n = 94) were retained for analysis. Vertical head and pelvic movements were measured with body mounted uniaxial accelerometers. Differences between vertical maximum and minimum head (HDmax, HDmin) and pelvic (PDmax, PDmin) heights between left and right forelimb and hindlimb stances were compared between straight line trot and lungeing in either direction. Vertical head and pelvic movements during lungeing were more asymmetric than during trot on a straight line. Common asymmetric patterns seen in the head were more upward movement during push-off of the outside forelimb and less downward movement during impact of the inside limb. Common asymmetric patterns seen in the pelvis were less upward movement during push-off of the outside hindlimb and less downward movement of the pelvis during impact of the inside hindlimb. Asymmetric patterns in one lunge direction were frequently not the same as in the opposite direction. Lungeing induces systematic asymmetries in vertical head and pelvic motion patterns in horses that may not be the same in both directions. These asymmetries may mask or mimic fore- or hindlimb lameness. © 2015 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.

  8. Straight Talk for Good Health | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Straight Talk for Good Health Straight Talk for Good Health Past Issues / Spring 2013 ... with your Doctor nihseniorhealth.gov/talkingwithyourdoctor/toc.html Straight talk with your healthcare provider is important. You ...

  9. Multiple-hit parameter estimation in monolithic detectors.

    Science.gov (United States)

    Hunter, William C J; Barrett, Harrison H; Lewellen, Tom K; Miyaoka, Robert S

    2013-02-01

    We examine a maximum-a-posteriori method for estimating the primary interaction position of gamma rays with multiple interaction sites (hits) in a monolithic detector. In assessing the performance of a multiple-hit estimator over that of a conventional one-hit estimator, we consider a few different detector and readout configurations of a 50-mm-wide square cerium-doped lutetium oxyorthosilicate block. For this study, we use simulated data from SCOUT, a Monte-Carlo tool for photon tracking and modeling scintillation- camera output. With this tool, we determine estimate bias and variance for a multiple-hit estimator and compare these with similar metrics for a one-hit maximum-likelihood estimator, which assumes full energy deposition in one hit. We also examine the effect of event filtering on these metrics; for this purpose, we use a likelihood threshold to reject signals that are not likely to have been produced under the assumed likelihood model. Depending on detector design, we observe a 1%-12% improvement of intrinsic resolution for a 1-or-2-hit estimator as compared with a 1-hit estimator. We also observe improved differentiation of photopeak events using a 1-or-2-hit estimator as compared with the 1-hit estimator; more than 6% of photopeak events that were rejected by likelihood filtering for the 1-hit estimator were accurately identified as photopeak events and positioned without loss of resolution by a 1-or-2-hit estimator; for PET, this equates to at least a 12% improvement in coincidence-detection efficiency with likelihood filtering applied.

  10. High energy ion hit technique to local area using microbeam

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Ryuichi; Kamiya, Tomihiro; Suda, Tamotsu; Sakai, Takuro; Hirao, Toshio; Kobayashi, Yasuhiko; Watanabe, Hiroshi [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    Single energetic ion hit technique has been developed as an application of ion microbeam technique, in order to study the effect of local damage or injury to materials and living organisms. The overall performance is basically defined by those of separate techniques: microbeam formation, microbeam positioning, single ion detection, detection signal processing, hit timing control, and hit verification. Recent progress on the developments of these techniques at JAERI-TIARA facility are reviewed. (author)

  11. Recent Improvements in the SHIELD-HIT Code

    DEFF Research Database (Denmark)

    Hansen, David Christoffer; Lühr, Armin Christian; Herrmann, Rochus

    2012-01-01

    Purpose: The SHIELD-HIT Monte Carlo particle transport code has previously been used to study a wide range of problems for heavy-ion treatment and has been benchmarked extensively against other Monte Carlo codes and experimental data. Here, an improved version of SHIELD-HIT is developed concentra......Purpose: The SHIELD-HIT Monte Carlo particle transport code has previously been used to study a wide range of problems for heavy-ion treatment and has been benchmarked extensively against other Monte Carlo codes and experimental data. Here, an improved version of SHIELD-HIT is developed...

  12. Equilibrium depth of scour at straight guide banks

    Science.gov (United States)

    Gjunsburgs, B.; Bulankina, V.

    2017-10-01

    The equilibrium stage of scour at the head of straight guide banks with a uniform and stratified bed conditions have been studied. The contraction of the river by bridge crossing with straight guide banks considerably alters the flow pattern. The streamlines become curve and the concentration of streamlines, longitudinal and transverse slopes of the water surface, a local increase in velocity, vortex and eddy structures, and the origin of a flow separation zone between the extreme streamlines and the guide bank are observed and local scour is developing at the head of the straight guide banks. New formulae for calculation of equilibrium depth of scour at straight guide banks at uniform and stratified river bed is elaborated and confirmed by tests and computer modelling results.

  13. Highly sensitive straightness measurement system using a ball-lens

    International Nuclear Information System (INIS)

    Lee, Minho; Yang, Hyun-Ik; Cho, Nahm-Gyoo

    2016-01-01

    In this paper, a new and simple optical technique to accurately measure the straightness errors of a linear stage is proposed. To improve the performance, including the measurement sensitivity and resolution of the measurement system, and to simultaneously measure two-dimensional straightness errors (2D straightness errors), an optical system was designed using a laser, a retro-reflector, a ball-lens, and a two-dimensional position sensitive detector (2D PSD). The characteristics of the measurement system were analytically and experimentally investigated. A prototype measurement system was manufactured based on the investigated results, and the performances of this system have been tested. The measuring performance of the system was easily improved by about 12 times using the proposed technique and it can be further improved. It is shown that the proposed technique can easily and effectively improve the performance of a conventional straightness measurement system based on the geometric optical method using a PSD. (paper)

  14. Straight studs from southern pine veneer cores and cordwood

    Science.gov (United States)

    Peter Koch

    1968-01-01

    An economically feasible system has been developed for converting southern pine veneer cores into straight 8-foot studs (2). Prototype studs - two per core - were 100 percent SPIB stud grade and better.

  15. Uncertainty of spatial straightness in 3D measurement

    International Nuclear Information System (INIS)

    Wang Jinxing; Jiang Xiangqian; Ma Limin; Xu Zhengao; Li Zhu

    2005-01-01

    The least-square method is commonly employed to verify the spatial straightness in actual three-dimensional measurement process, but the uncertainty of the verification result is usually not given by the coordinate measuring machines. According to the basic principle of spatial straightness least-square verification and the uncertainty propagation formula given by ISO/TS 14253-2, a calculation method for the uncertainty of spatial straightness least-square verification is proposed in this paper. By this method, the coefficients of the line equation are regarded as a statistical vector, so that the line equation, the result of the spatial straightness verification and the uncertainty of the result can be obtained after the expected value and covariance matrix of the vector are determined. The method not only assures the integrity of the verification result, but also accords with the requirement of the new generation of GPS standards, which can improve the veracity of verification

  16. Qingping Straight Sword: The Last Remaining Chinese Sword System?

    Directory of Open Access Journals (Sweden)

    Stephan Berwick

    2012-07-01

    Full Text Available The following examination of classical Chinese straight sword (jian details the very rare Qingping straight sword system. The study meshes Chinese- and English-sourced research with a revealing interview (conducted by America’s senior Qingping disciples, Reza Momenan and Hon Lee with Lu Junhai—the grandmaster of this unique sword system. The author presents Qingping system as perhaps the only known, complete Chinese sword system surviving from China’s pre-Rebulican era (1911-1949.

  17. Straight leg elevation to rule out pelvic injury.

    Science.gov (United States)

    Bolt, Caroline; O'Keeffe, Francis; Finnegan, Pete; Dickson, Kristofer; Smit, De Villiers; Fitzgerald, Mark C; Mitra, Biswadev

    2018-02-01

    Pelvic x-ray is frequently used as a screening tool during initial assessment of injured patients. However routine use in the awake and alert blunt trauma patient may be questioned due to low yield. We propose a clinical tool that may avoid unnecessary imaging by examining whether the ability to straight leg raise, without pain, can rule out pelvic injury. We conducted a prospective cohort study with the exposure variables of ability to straight leg raise and presence of pain on doing so, and presence of pelvic fracture on x-ray as the primary outcome variable. Of the 328 participants, 35 had pelvic fractures, and of these 32 were either unable to straight leg raise, or had pain on doing so, with a sensitivity of 91.43% (95% CI: 76.94-98.2%) and a negative predictive value of 98.57% (95% CI: 95.88-99.70%). The 3 participants with a pelvic fracture who could straight leg raise with no pain, all had a GCS of less than 15, and therefore, among the sub-group of patients with GCS15, a 100% sensitivity and 100% negative predictive value for straight leg raise with no pain to rule out pelvic fracture was demonstrated. Among awake, alert patients, painless straight leg raise can exclude pelvic fractures and be incorporated into initial examination during reception and resuscitation of injured patients. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  18. Biomechanical differences in the stem straightening process among Pinus pinaster provenances. A new approach for early selection of stem straightness.

    Science.gov (United States)

    Sierra-de-Grado, Rosario; Pando, Valentín; Martínez-Zurimendi, Pablo; Peñalvo, Alejandro; Báscones, Esther; Moulia, Bruno

    2008-06-01

    Stem straightness is an important selection trait in Pinus pinaster Ait. breeding programs. Despite the stability of stem straightness rankings in provenance trials, the efficiency of breeding programs based on a quantitative index of stem straightness remains low. An alternative approach is to analyze biomechanical processes that underlie stem form. The rationale for this selection method is that genetic differences in the biomechanical processes that maintain stem straightness in young plants will continue to control stem form throughout the life of the tree. We analyzed the components contributing most to genetic differences among provenances in stem straightening processes by kinetic analysis and with a biomechanical model defining the interactions between the variables involved (Fournier's model). This framework was tested on three P. pinaster provenances differing in adult stem straightness and growth. One-year-old plants were tilted at 45 degrees, and individual stem positions and sizes were recorded weekly for 5 months. We measured the radial extension of reaction wood and the anatomical features of wood cells in serial stem cross sections. The integral effect of reaction wood on stem leaning was computed with Fournier's model. Responses driven by both primary and secondary growth were involved in the stem straightening process, but secondary-growth-driven responses accounted for most differences among provenances. Plants from the straight-stemmed provenance showed a greater capacity for stem straightening than plants from the sinuous provenances mainly because of (1) more efficient reaction wood (higher maturation strains) and (2) more pronounced secondary-growth-driven autotropic decurving. These two process-based traits are thus good candidates for early selection of stem straightness, but additional tests on a greater number of genotypes over a longer period are required.

  19. Wind tunnel study of helical and straight-bladed vertical-axis wind turbine wakes

    Science.gov (United States)

    Bagheri, Maryam; Araya, Daniel

    2017-11-01

    It is hypothesized that blade curvature can serve as a passive means to control fluid entrainment and wake recovery in vertical-axis wind turbine (VAWT) arrays. We test this experimentally in a wind tunnel using two different VAWT configurations, one with straight blades and another with helical blades, keeping all other experimental parameters fixed. A small-scale, commercially available VAWT (15W max power) is used as the baseline wind tunnel model in each case. The commercial VAWT blades are replaced with either straight or helical blades that are 3D-printed extrusions of the same airfoil cross-section. Results from smoke flow visualization, three-component wake velocity measurements, and turbine power data are presented. These results give insight into the potential use of VAWTs with curved blades in utility-scale wind farms.

  20. A Two-Hit Model of Autism: Adolescence as the Second Hit

    Science.gov (United States)

    Picci, Giorgia; Scherf, K. Suzanne

    2015-01-01

    Adolescence brings dramatic changes in behavior and neural organization. Unfortunately, for some 30% of individuals with autism, there is marked decline in adaptive functioning during adolescence. We propose a two-hit model of autism. First, early perturbations in neural development function as a “first hit” that sets up a neural system that is “built to fail” in the face of a second hit. Second, the confluence of pubertal hormones, neural reorganization, and increasing social demands during adolescence provides the “second hit” that interferes with the ability to transition into adult social roles and levels of adaptive functioning. In support of this model, we review evidence about adolescent-specific neural and behavioral development in autism. We conclude with predictions and recommendations for empirical investigation about several domains in which developmental trajectories for individuals with autism may be uniquely deterred in adolescence. PMID:26609500

  1. AXAOTHER XL -- A spreadsheet for determining doses for incidents caused by tornadoes or high-velocity straight winds

    International Nuclear Information System (INIS)

    Simpkins, A.A.

    1996-09-01

    AXAOTHER XL is an Excel Spreadsheet used to determine dose to the maximally exposed offsite individual during high-velocity straight winds or tornado conditions. Both individual and population doses may be considered. Potential exposure pathways are inhalation and plume shine. For high-velocity straight winds the spreadsheet has the capability to determine the downwind relative air concentration, however for the tornado conditions, the user must enter the relative air concentration. Theoretical models are discussed and hand calculations are performed to ensure proper application of methodologies. A section has also been included that contains user instructions for the spreadsheet

  2. Isolated orbital mass as the primary presentation of a triple-hit lymphoma transformed from a systemic follicular lymphoma

    Directory of Open Access Journals (Sweden)

    Xiao Yi Zhou

    2018-06-01

    Full Text Available Purpose: Triple-hit lymphoma is a highly aggressive B-cell lymphoma. We report a case of triple-hit lymphoma transformed from systemic follicular lymphoma (FL after 9-year remission and presented primarily as an isolated orbital mass without systemic symptoms or lymphadenopathy. Observations: A 58-year-old female presented with intermittent vertical binocular diplopia, left upper eyelid swelling and pain and was found to have a 2.9 cm orbital mass. Histological section revealed a CD10-positive large B-cell lymphoma, consistent with transformation of FL. Fluorescent in situ hybridization (FISH analysis demonstrated rearrangements involving C-MYC, BCL-2 and BCL-6 genes, indicating a high grade, triple-hit lymphoma. Conclusions and importance: Triple-hit lymphoma transformed from a low-grade lymphoma may initially present as an isolated orbital mass without systemic evidence of transformation. Early recognition of double or triple-hit lymphomas is important since these patients require aggressive chemotherapy. Keywords: Lymphoma, Triple-hit lymphoma, Orbital mass

  3. Modeling analyses of two-phase flow instabilities for straight and helical tubes in nuclear power plants

    International Nuclear Information System (INIS)

    Dong, Ruiting; Niu, Fenglei; Zhou, Yuan; Yu, Yu; Guo, Zhangpeng

    2016-01-01

    Highlights: • Two-phase flow instabilities in straight and helical tubes were studied. • The effects of system pressure, mass flux, inlet subcooling on DWO were studied. • The simulation results are consistent with the experimental results. • The RELAP5 results are consistent with frequency domain method results. - Abstract: The effects of system pressure, mass flux and inlet subcooling on two-phase flow instability for the test section consisted of two heated straight channels or two helical channels are studied by means of RELAP5/MOD3.3 and multi-variable frequency domain control theory. The experimental data in two straight channels are used to verify the RELAP5 and multi-variable frequency domain control theory results. The thermal hydraulic behaviors and parametric effects are simulated and compared with the experimental data. The RELAP5 results show that the flow stability increases with the system pressure, mass velocity, and inlet subcooling at high subcoolings. The frequency domain theory presents the same results as those given by the time domain theory (RELAP5). The effects of system pressure, mass velocity and inlet subcooling are simulated to find the difference between the straight and the helical tube flows. The RELAP5 and the multi-variable frequency domain control theory are used in modeling and simulating density wave oscillation to study their advantages and disadvantages in straight and helical tubes.

  4. Modeling analyses of two-phase flow instabilities for straight and helical tubes in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Ruiting [Beijing Key Laboratory of Passive Nuclear Power Safety and Technology, North China Electric Power University, Beijing 102206 (China); Niu, Fenglei, E-mail: niufenglei@ncepu.edu.cn [Beijing Key Laboratory of Passive Nuclear Power Safety and Technology, North China Electric Power University, Beijing 102206 (China); Zhou, Yuan [School of Nuclear Science and Engineering, Shanghai Jiaotong University, Shanghai 200240 (China); Yu, Yu; Guo, Zhangpeng [Beijing Key Laboratory of Passive Nuclear Power Safety and Technology, North China Electric Power University, Beijing 102206 (China)

    2016-10-15

    Highlights: • Two-phase flow instabilities in straight and helical tubes were studied. • The effects of system pressure, mass flux, inlet subcooling on DWO were studied. • The simulation results are consistent with the experimental results. • The RELAP5 results are consistent with frequency domain method results. - Abstract: The effects of system pressure, mass flux and inlet subcooling on two-phase flow instability for the test section consisted of two heated straight channels or two helical channels are studied by means of RELAP5/MOD3.3 and multi-variable frequency domain control theory. The experimental data in two straight channels are used to verify the RELAP5 and multi-variable frequency domain control theory results. The thermal hydraulic behaviors and parametric effects are simulated and compared with the experimental data. The RELAP5 results show that the flow stability increases with the system pressure, mass velocity, and inlet subcooling at high subcoolings. The frequency domain theory presents the same results as those given by the time domain theory (RELAP5). The effects of system pressure, mass velocity and inlet subcooling are simulated to find the difference between the straight and the helical tube flows. The RELAP5 and the multi-variable frequency domain control theory are used in modeling and simulating density wave oscillation to study their advantages and disadvantages in straight and helical tubes.

  5. Dos aproximaciones a la metodología de diseño a momento flexionante de secciones T en concreto reforzado que se comportan como rectangulares y constituyen la sección recta de la viguetería de losas aligeradas Two approaches to design methodology at T sections bending moment in reinforced concrete which behave as rectangular sections and constitute the straight sections of beams of light slabs

    Directory of Open Access Journals (Sweden)

    José Christian Chanchí Golondrino

    2008-01-01

    Full Text Available El presente artículo esboza dos aproximaciones sobre la ecuación de diseño a momento flexionante de secciones T en concreto reforzado que se comportan como secciones rectangulares y que trabajan como viguetería de losas aligeradas. La primera aproximación discute la viabilidad de usar el ancho del nervio de la vigueta en lugar de usar el ancho efectivo de la aleta, dentro del proceso de la obtención del acero, requerida para asumir un momento flexionante; la segunda aproximación discute la viabilidad de aproximar la ecuación cuadrática que rige la obtención del área del acero requerida para obtener un momento flexionante en una ecuación lineal, cuyas únicas variables son el área del acero y la altura efectiva de la sección T. Se ha dimensionado geométricamente un conjunto de secciones de losas aligeradas siguiendo los requisitos del título C13 de la norma sismo resistente colombiana NSR98, los cuales se obtuvieron para un modelo simplemente apoyado, cuya luz varía entre [2 - 7] m y el ancho del casetón ente [0.30 - 1] m. El dimensionamiento antes mencionado fue utilizado para sensibilizar la efectividad de cada una de las aproximaciones propuestas respecto a la solución general para la obtención del área del acero de la sección T que se comporta como rectangular.This article presents two approaches on the moment design equation of T shaped beams. Particularly the beam's T cross section analyzed behaves like a rectangular cross section when the beam works like a component of a slab system built from a set of T shaped beams. The first approach discusses the feasibility to use the web width instead of effective flange width to obtain the steel area associated to the moment solicitation of T shaped beam. The second approach discusses the feasibility to approach the quadratic equation used to obtain the steel required to take the bending moment into linear equation related to variables such as steel area and the effective depth

  6. Current insights into the laboratory diagnosis of HIT.

    Science.gov (United States)

    Bakchoul, T; Zöllner, H; Greinacher, A

    2014-06-01

    Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction and prothrombotic disorder caused by immunization against platelet factor 4 (PF4) after complex formation with heparin or other polyanions. After antibody binding to PF4/heparin complexes, HIT antibodies are capable of intravascular platelet activation by cross-linking Fc gamma receptor IIa (FcγRIIa) on the platelet surface leading to a platelet count decrease and/or thrombosis. In contrast to most other immune-mediated disorders, the currently available laboratory tests for anti-PF4/heparin antibodies show a high sensitivity also for clinically irrelevant antibodies. This makes the diagnosis of HIT challenging and bears the risk to substantially overdiagnose HIT. The strength of the antigen assays for HIT is in ruling out HIT when the test is negative. Functional assays have a higher specificity for clinically relevant antibodies, but they are restricted to specialized laboratories. Currently, a Bayesian approach combining the clinical likelihood estimation for HIT with laboratory tests is the most appropriate approach to diagnose HIT. In this review, we give an overview on currently available diagnostic procedures and discuss their limitations. © 2014 John Wiley & Sons Ltd.

  7. Reduction of multiple hits in atom probe tomography

    International Nuclear Information System (INIS)

    Thuvander, Mattias; Kvist, Anders; Johnson, Lars J.S.; Weidow, Jonathan; Andrén, Hans-Olof

    2013-01-01

    The accuracy of compositional measurements using atom probe tomography is often reduced because some ions are not recorded when several ions hit the detector in close proximity to each other and within a very short time span. In some cases, for example in analysis of carbides, the multiple hits result in a preferential loss of certain elements, namely those elements that frequently field evaporate in bursts or as dissociating molecules. In this paper a method of reducing the effect of multiple hits is explored. A fine metal grid was mounted a few millimeters behind the local electrode, effectively functioning as a filter. This resulted in a decrease in the overall detection efficiency, from 37% to about 5%, but also in a decrease in the fraction of multiple hits. In an analysis of tungsten carbide the fraction of ions originating from multiple hits decreased from 46% to 10%. As a result, the measured carbon concentration increased from 48.2 at%to 49.8 at%, very close to the expected 50.0 at%. The characteristics of the multiple hits were compared for analyses with and without the grid filter. - Highlights: ► APT experiments have been performed with a reduced amount of multiple hits. ► The multiple hits were reduced by placing a grid behind the electrode. ► This resulted in improved carbon measurement of WC

  8. Scalar localization by cone-beam computed tomography of cochlear implant carriers: a comparative study between straight and periomodiolar precurved electrode arrays.

    Science.gov (United States)

    Boyer, Eric; Karkas, Alexandre; Attye, Arnaud; Lefournier, Virginie; Escude, Bernard; Schmerber, Sebastien

    2015-03-01

    To compare the incidence of dislocation of precurved versus straight flexible cochlear implant electrode arrays using cone-beam computed tomography (CBCT) image analyses. Consecutive nonrandomized case-comparison study. Tertiary referral center. Analyses of patients' CBCT images after cochlear implant surgery. Precurved and straight flexible electrode arrays from two different manufacturers were implanted. A round window insertion was performed in most cases. Two cases necessitated a cochleostomy. The patients' CBCT images were reconstructed in the coronal oblique, sagittal oblique, and axial oblique section. The insertion depth angle and the incidence of dislocation from the scala tympani to the scala vestibuli were determined. The CBCT images and the incidence of dislocation were analyzed in 54 patients (61 electrode arrays). Thirty-one patients were implanted with a precurved perimodiolar electrode array and 30 patients with a straight flexible electrode array. A total of nine (15%) scalar dislocations were observed in both groups. Eight (26%) scalar dislocations were observed in the precurved array group and one (3%) in the straight array group. Dislocation occurred at an insertion depth angle between 170 and 190 degrees in the precurved array group and at approximately 370 degrees in the straight array group. With precurved arrays, dislocation usually occurs in the ascending part of the basal turn of the cochlea. With straight flexible electrode arrays, the incidence of dislocation was lower, and it seems that straight flexible arrays have a higher chance of a confined position within the scala tympani than perimodiolar precurved arrays.

  9. 42 CFR 495.340 - As-needed HIT PAPD update and as-needed HIT IAPD update requirements.

    Science.gov (United States)

    2010-10-01

    ... limited to any of the following: (a) A projected cost increase of $100,000 or more. (b) A schedule... implementation approach, or scope of activities beyond that approved in the HIT planning advance planning document or the HIT implementation advance planning document. (d) A change in implementation concept or a...

  10. Straight-Line: A nuclear material storage information management system

    International Nuclear Information System (INIS)

    Nilsen, C.; Mangan, D.

    1995-01-01

    Sandia National Laboratories is developing Straight-Line -- a pilot system to demonstrate comprehensive monitoring of nuclear material in storage. Straight-Line is an integrated system of sensors providing information that will enhance the safety, security, and international accountability of stored nuclear material. The goals of this effort are to: (1) Provide the right sensor information to the right user immediately. (2) Reduce the expenses, risks, and frequency of human inspection of the material. (3) Provide trustworthy data to international inspectors to minimize their need to make on site inspections. In pursuit of these goals, Straight-Line unites technology from Sandia's Authenticated Item Monitoring System (AIMS) and other programs to communicate the authenticated status of the monitored item back to central magazine receivers. Straight-Line, however, incorporates several important features not found in previous systems: (1) Information Security -- the ability to collect and safely disseminate both classified and unclassified sensor data to users on a need-to-know basis. (2) Integrate into a single system the monitoring needs of safety, security, and international accountability. (3) Incorporate the use of sensors providing analog or digital output. This paper will present the overall architecture and status of the Straight-Line project

  11. Preferences of AP position of the straight Caucasian facial profile.

    Science.gov (United States)

    Mees, Steven; Jiménez Bellinga, Raúl; Mommaerts, Maurice Y; De Pauw, Guy A M

    2013-12-01

    Several investigators have compared the perception of profile attractiveness between professional and non-professional people, different groups of clinicians, and different ethnic groups. Our aim was to study preferences for facial protrusion in the lateral view for a straight Class I profile and to study the influence of gender, age, sex preference, and profession. Portrait images of one male and one female model with a Class I occlusal relationship were warped into nine different antero-posterior positions. An internet site was established to reach as many people as possible, and a request was sent by email to participate in a scientific experiment. Finally, 1707 Caucasion assessors could be grouped. The preferred male profile is the straight full ante profile. For a feminine facial profile, the straight average and the straight 2/3 ante profiles were perceived as the most attractive. Surgeons tended to give significantly higher scores to attractive (ante) profiles, which correlated strongly with scores of the orthodontists. Whenever possible with combined orthodontic/surgery treatment, straight ante profiles should be aimed for. Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  12. Visual straight-ahead preference in saccadic eye movements.

    Science.gov (United States)

    Camors, Damien; Trotter, Yves; Pouget, Pierre; Gilardeau, Sophie; Durand, Jean-Baptiste

    2016-03-15

    Ocular saccades bringing the gaze toward the straight-ahead direction (centripetal) exhibit higher dynamics than those steering the gaze away (centrifugal). This is generally explained by oculomotor determinants: centripetal saccades are more efficient because they pull the eyes back toward their primary orbital position. However, visual determinants might also be invoked: elements located straight-ahead trigger saccades more efficiently because they receive a privileged visual processing. Here, we addressed this issue by using both pro- and anti-saccade tasks in order to dissociate the centripetal/centrifugal directions of the saccades, from the straight-ahead/eccentric locations of the visual elements triggering those saccades. Twenty participants underwent alternating blocks of pro- and anti-saccades during which eye movements were recorded binocularly at 1 kHz. The results confirm that centripetal saccades are always executed faster than centrifugal ones, irrespective of whether the visual elements have straight-ahead or eccentric locations. However, by contrast, saccades triggered by elements located straight-ahead are consistently initiated more rapidly than those evoked by eccentric elements, irrespective of their centripetal or centrifugal direction. Importantly, this double dissociation reveals that the higher dynamics of centripetal pro-saccades stem from both oculomotor and visual determinants, which act respectively on the execution and initiation of ocular saccades.

  13. Straight-Line -- A nuclear material storage information management system

    Energy Technology Data Exchange (ETDEWEB)

    Nilsen, C. [Sandia National Labs., Livermore, CA (United States); Mangan, D. [Sandia National Labs., Albuquerque, NM (United States)

    1995-12-31

    Sandia National Laboratories is developing Straight-Line -- a pilot system to demonstrate comprehensive monitoring of nuclear material in storage. Straight-Line is an integrated system of sensors providing information that will enhance the safety, security, and international accountability of stored nuclear material. The goals of this effort are to (1) Provide the right sensor information to the right user in a timely manner. (2) Reduce the expenses, risks, and frequency of human inspection of the material. (3) Provide trustworthy data to international inspectors to minimize their need to make on site inspections. In pursuit of these goals, Straight-Line unites technology from Sandia`s Authenticated Item Monitoring System (AIMS) and other programs to communicate the authenticated status of the monitored item back to central magazine receivers. Straight-Line, however, incorporates several important features not found in previous systems: (1) Information Security -- the ability to collect and safely disseminate both classified and unclassified sensor data to users on a need-to-know basis. (2) Integrate into a single system the monitoring needs of safety, security, and international accountability. (3) Incorporate the use of sensors providing analog or digital output. This paper will present the overall architecture and status of the Straight-Line project.

  14. Straight-Line: A nuclear material storage information management system

    Energy Technology Data Exchange (ETDEWEB)

    Nilsen, C.; Mangan, D.

    1995-07-01

    Sandia National Laboratories is developing Straight-Line -- a pilot system to demonstrate comprehensive monitoring of nuclear material in storage. Straight-Line is an integrated system of sensors providing information that will enhance the safety, security, and international accountability of stored nuclear material. The goals of this effort are to: (1) Provide the right sensor information to the right user immediately. (2) Reduce the expenses, risks, and frequency of human inspection of the material. (3) Provide trustworthy data to international inspectors to minimize their need to make on site inspections. In pursuit of these goals, Straight-Line unites technology from Sandia`s Authenticated Item Monitoring System (AIMS) and other programs to communicate the authenticated status of the monitored item back to central magazine receivers. Straight-Line, however, incorporates several important features not found in previous systems: (1) Information Security -- the ability to collect and safely disseminate both classified and unclassified sensor data to users on a need-to-know basis. (2) Integrate into a single system the monitoring needs of safety, security, and international accountability. (3) Incorporate the use of sensors providing analog or digital output. This paper will present the overall architecture and status of the Straight-Line project.

  15. Straight eye for the gay guy: composing queerness.

    Science.gov (United States)

    Alexander, Jonathan

    2010-01-01

    Drawing on the work of Didier Eribon and his theorization of the construction of gay male subjectivity, this article examines different "texts," broadly defined, that grapple specifically with straight men attempting to represent male homosexuality: Norman Mailer's essay, "The Homosexual Villain"; the Bravo reality television series Boy Meets Boy, and Michael Griffith's short story, "Hooper Gets a Perm." These texts represent attempts by straight authors to grapple with queer experience in ways that move the imagination of queers beyond simple stereotypes or uncritical explorations of the sexual "other." In the process of examining these texts, the following questions are addressed: What happens when a straight man attempts to represent a gay man? Does he "get it right," and is such a question even useful? More specifically, what is the value in having straights imagine queerness? Is such an imagining possible? Is such desirable? And, if so, what are the contours of such an imagining-as well as its possibilities and limitations, pedagogically, personally, and politically? Ultimately, I contend that the straight imagining of queerness offers rich potential for mutual understanding; furthermore, attempting to understand what goes into the making of those representations tells us much about how queerness circulates in our culture as a subject, a figure of discussion, contention, and representation.

  16. Straight-Line -- A nuclear material storage information management system

    International Nuclear Information System (INIS)

    Nilsen, C.; Mangan, D.

    1995-01-01

    Sandia National Laboratories is developing Straight-Line -- a pilot system to demonstrate comprehensive monitoring of nuclear material in storage. Straight-Line is an integrated system of sensors providing information that will enhance the safety, security, and international accountability of stored nuclear material. The goals of this effort are to (1) Provide the right sensor information to the right user in a timely manner. (2) Reduce the expenses, risks, and frequency of human inspection of the material. (3) Provide trustworthy data to international inspectors to minimize their need to make on site inspections. In pursuit of these goals, Straight-Line unites technology from Sandia's Authenticated Item Monitoring System (AIMS) and other programs to communicate the authenticated status of the monitored item back to central magazine receivers. Straight-Line, however, incorporates several important features not found in previous systems: (1) Information Security -- the ability to collect and safely disseminate both classified and unclassified sensor data to users on a need-to-know basis. (2) Integrate into a single system the monitoring needs of safety, security, and international accountability. (3) Incorporate the use of sensors providing analog or digital output. This paper will present the overall architecture and status of the Straight-Line project

  17. Hitting your foothills target the first time

    Energy Technology Data Exchange (ETDEWEB)

    Ewanek, J. [MI Drilling Fluids Canada, Calgary, AB (Canada); Young, S. [M-I L.L.C., Calgary, AB (Canada)

    2001-07-01

    As the demand for gas increases, operators are exploring for more long-term gas reserves in the foothills and in more complex structural traps and reservoirs. The high tectonic activity in the foothills has rendered the structural geology complex, making it difficult to hit an exploration target the first time. Costly sidetracking operations are common. The use of oil based fluids is often necessary for drilling in such technically challenging environments. However, dips/structural evaluation tools such as the Formation Micro Imager (FMI) and the GeoVision 675 Logging While Drilling (LWD) tool cannot be used because of the non-conductive nature of oil based fluids. Therefore, a conductive oil based fluid was developed with the recent advances in oil based mud technology, and it is now available. This new conductive oil based fluid allows LWD tools to transmit structural information in real time and FMI logs to give detailed structural information while wireline logging the hole. The combination of LWD and FMI data plus a conductive oil based fluid makes it possible to gather better structural information while drilling. This minimizes sidetracks and leads to a better understanding of the structural geology in that field. It was concluded that the use of this technology well enable better pre-planning on future well sites and will make it possible to reduce costs associated with drilling and oilfield operations in the foothills. 9 refs., 2 tabs., 13 figs.

  18. The first neutron beam hits EAR2

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    On 25 July 2014, about a year after construction work began, the Experimental Area 2 (EAR2) of CERN’s neutron facility n_TOF recorded its first beam. Unique in many aspects, EAR2 will start its rich programme of experimental physics this autumn.   The last part of the EAR2 beamline: the neutrons come from the underground target and reach the top of the beamline, where they hit the samples. Built about 20 metres above the neutron production target, EAR2 is in fact a bunker connected to the n_TOF underground facilities via a duct 80 cm in diameter, where the beamline is installed. The feet of the bunker support pillars are located on the concrete structure of the n_TOF tunnel and part of the structure lies above the old ISR building. A beam dump located on the roof of the building completes the structure. Neutrons are used by physicists to study neutron-induced reactions with applications in a number of fields, including nuclear waste transmutation, nuclear technology, nuclear astrop...

  19. Dynamic mechanical properties of straight titanium alloy arch wires.

    Science.gov (United States)

    Kusy, R P; Wilson, T W

    1990-10-01

    Eight straight-wire materials were studied: an orthodontic titanium-molybdenum (Ti-Mo) product, TMA; three orthodontic nickel-titanium (Ni-Ti) products, Nitinol, Titanal, and Orthonol; three prototype alloys, a martensitic, an austenitic, and a biphasic alloy; and a hybrid shape-memory-effect product, Biometal. Each wire was prepared with a length-to-cross-sectional area of at least 3600 cm-1. With an Autovibron Model DDV-II-C used in the tensile mode, each sample was scanned from -120 to +200 degrees C at 2 degrees C/min. From the data base, plots of the log storage modulus, log tan delta, and percent change in length vs. temperature were generated. Results showed that the dynamic mechanical properties of the alloys within this TI system are quite different. The Ti-Mo alloy, TMA, was invariant with temperature, having a modulus of 7.30 x 10(11) dyne/cm2 (10.6 x 10(6) psi). The three cold-worked alloys--Nitinol, Titanal, and Orthonol--appeared to be similar, having a modulus of 5.74 x 10(11) dyne/cm2 (8.32 x 10(6) psi). The biphasic shape-memory alloy displayed a phase transformation near ambient temperature; whereas the hybrid shape-memory product, Biometal, underwent a 3-5% change in length during its transformation between 95 and 125 degrees C. Among the Ni-Ti wires tested, several different types of alloys were represented by this intermetallic material.

  20. A mathematical model for camera calibration based on straight lines

    Directory of Open Access Journals (Sweden)

    Antonio M. G. Tommaselli

    2005-12-01

    Full Text Available In other to facilitate the automation of camera calibration process, a mathematical model using straight lines was developed, which is based on the equivalent planes mathematical model. Parameter estimation of the developed model is achieved by the Least Squares Method with Conditions and Observations. The same method of adjustment was used to implement camera calibration with bundles, which is based on points. Experiments using simulated and real data have shown that the developed model based on straight lines gives results comparable to the conventional method with points. Details concerning the mathematical development of the model and experiments with simulated and real data will be presented and the results with both methods of camera calibration, with straight lines and with points, will be compared.

  1. Bent versus straight tips in micropulsed longitudinal phacoemulsification.

    Science.gov (United States)

    Stagg, Brian C; Gupta, Isha; Cahoon, Judd; Ronquillo, Cecinio; Shi, Dallas; Zaugg, Brian; Gardiner, Gareth; Barlow, William R; Pettey, Jeff H; Aabid Farukhi, M; Jensen, Jason; Olson, Randall J

    2015-10-01

    The aim of this study was to evaluate bent and straight phacoemulsification tips to determine which tip is more efficient in removal of lens fragments, using micropulsed longitudinal ultrasound in phacoemulsification. In vitro laboratory study. The John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, Utah, was the study setting. Pig lenses hardened in a manner comparable with dense human cataracts were cut into 2-mm cubes and removed with micropulsed longitudinal ultrasound using settings previously shown to be optimally efficient (6 milliseconds on and 6 milliseconds off for a bent tip). To verify this time as most efficient for a straight tip, we also tested times of 5, 6, and 7 milliseconds time on and off. The tips were either straight or with a 20-degree bend. Twenty cubes were used for each comparative run. For the straight tip, 6 milliseconds on (1.56 ± 0.815 seconds) was significantly more efficient than 7 milliseconds on (2.45 ± 1.56 seconds, p = 0.001) and not significantly more efficient than 5 milliseconds on (1.69 ± 0.86 seconds, p = 0.43). Five milliseconds off time (1.45 ± 0.76s) was more efficient than 6 milliseconds (2.06 ± 1.37 seconds, p = 0.004) and 7 milliseconds off (2.18 ± 1.24s, p = 0.001). The straight tip was more efficient than the bent tip (1.38 ± 0.83 versus 2.93 ± 2.14 seconds, p = 0.006). Results are contrary to accepted common belief. Micropulsed longitudinal phacoemulsification is more efficient with a straight rather than a bent tip. Copyright © 2015 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  2. Radical heterosexuality: Straight teacher activism in schools : Does ally-led activism work?

    Directory of Open Access Journals (Sweden)

    Leigh Potvin

    2016-06-01

    Here, I explore the efficacy of straight teacher allies, the importance of understanding straight privilege, and the significance of radical heterosexuality for straight people doing LGBTQ activism. Relying on queer theory and decolonizing/Indigenous queer theory, I argue that it is necessary for straight teachers to acknowledge their straight privilege in order to challenge homophobia's companions: heterosexism and heteronormativity. In addressing the latter two covert forms of oppression in schools, teachers and students could shift into deeper, more effective resistance measures.

  3. A generalized, periodic nonlinearity-reduced interferometer for straightness measurements

    International Nuclear Information System (INIS)

    Wu Chienming

    2008-01-01

    Periodic nonlinearity is a systematic error limiting the accuracy of displacement measurements at the nanometer level. However, an interferometer with a displacement measurement accuracy of less than 1 nm is required in nanometrology and in fundamental scientific research. To meet this requirement, a generalized, periodic nonlinearity-reduced interferometer, based on three construction principles has been developed for straightness measurements. These three construction principles have resulted in an interferometer with a highly stable design with reduced periodic nonlinearity. Verifications by a straightness interferometer have demonstrated that the periodic nonlinearity was less than 40 pm. The results also demonstrate that the interferometer design is capable of subnanometer accuracy and is useful in nanometrology

  4. Fatigue test results of straight pipe with flaws in inner surface

    International Nuclear Information System (INIS)

    Shibata, Katsuyuki; Oba, Toshihiro; Kawamura, Takaichi; Yokoyama, Norio; Miyazono, Shohachiro

    1981-01-01

    Fatigue and fracture tests of piping models with flaws in the inner surface were carried out to investigate the fatigue crack growth, coalescence of multiple cracks and fracture behavior. Two straight test pipes with and without weldment in the test section of SUS304L stainless steel were tested under almost the same test conditions. Three artificial defects were machined in the inner surface of the test section of the test pipes. The fatigue test were performed untill the cracks coalesced and grew through the thickness. Subsequently, a static load was imposed on test pipe which contained a large crack in the test section. The test results show that the fatigue crack growth is slower than that predicted by the method specified in the Section XI of ASME Boiler and Pressure Vessel Code, and that the test pipes can endure more than the static load of 3Sm without an unstable fracture. (author)

  5. Implementation of a rapid HIT immunoassay at a university hospital - Retrospective analysis of HIT laboratory orders in patients with thrombocytopenia.

    Science.gov (United States)

    Black, Anne; Heimerl, Susanne; Oertli, Linnéa; Wilczek, Wolf; Greinacher, Andreas; Spannagl, Michael; Herr, Wolfgang; Hart, Christina

    2017-10-01

    Heparin-induced thrombocytopenia (HIT) is a rare cause of thrombocytopenia and a potentially life-threatening adverse drug reaction. Clinical overdiagnosis of HIT results in costly laboratory tests and anticoagulation. Criteria and algorithms for diagnosis are established, but their translation into clinical practice is still challenging. In a retrospective approach we studied all HIT related laboratory test requests within four years and evaluated data before (1st period, 24month) and after (2nd period, 24month) replacing particle gel immunoassay (PaGIA) and enzyme-linked immunosorbent assay (ELISA) by a chemiluminescent immunoassay (CLIA). HIT was confirmed by heparin-induced platelet activation (HIPA) test. Clinical pretest probability for HIT using an implemented simplified 4Ts score and platelet count were evaluated. Costs for laboratory tests and alternative anticoagulation were calculated. In 1850 patients with suspected HIT, 2327 laboratory orders were performed. In 87.2% of these orders an intermediate/high simplified 4Ts score was found. Thrombocytopenia was present in 87.1%. After replacing PaGIA and ELISA by CLIA the number of immunological and functional laboratory tests was reduced by 38.2%. The number of positive HIT immunoassays declined from 22.6% to 6.0%, while the number of positive HIPA tests among positive immunological tests increased by 19%. Altogether, acute HIT was confirmed in 59 patients. A decline in the use of alternative anticoagulants was observed in the 2nd period. Our study shows that in a university hospital setting HIT is well-known, but diagnosis requires a precise laboratory confirmation. Replacing PaGIA and ELISA by CLIA did not influence laboratory order behavior but results in reduced overall costs for laboratory diagnostics and alternative anticoagulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Visual strategies underpinning the development of visual-motor expertise when hitting a ball.

    Science.gov (United States)

    Sarpeshkar, Vishnu; Abernethy, Bruce; Mann, David L

    2017-10-01

    It is well known that skilled batters in fast-ball sports do not align their gaze with the ball throughout ball-flight, but instead adopt a unique sequence of eye and head movements that contribute toward their skill. However, much of what we know about visual-motor behavior in hitting is based on studies that have employed case study designs, and/or used simplified tasks that fall short of replicating the spatiotemporal demands experienced in the natural environment. The aim of this study was to provide a comprehensive examination of the eye and head movement strategies that underpin the development of visual-motor expertise when intercepting a fast-moving target. Eye and head movements were examined in situ for 4 groups of cricket batters, who were crossed for playing level (elite or club) and age (U19 or adult), when hitting balls that followed either straight or curving ('swinging') trajectories. The results provide support for some widely cited markers of expertise in batting, while questioning the legitimacy of others. Swinging trajectories alter the visual-motor behavior of all batters, though in large part because of the uncertainty generated by the possibility of a variation in trajectory rather than any actual change in trajectory per se. Moreover, curving trajectories influence visual-motor behavior in a nonlinear fashion, with targets that curve away from the observer influencing behavior more than those that curve inward. The findings provide a more comprehensive understanding of the development of visual-motor expertise in interception. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  7. Classical and quantum chaos in a circular billiard with a straight cut

    International Nuclear Information System (INIS)

    Ree, S.; Reichl, L.E.

    1999-01-01

    We study classical and quantum dynamics of a particle in a circular billiard with a straight cut. Classically, this system can be integrable, nonintegrable with soft chaos, or nonintegrable with hard chaos as we vary the size of the cut. We plot Poincaracute e surfaces of section to study chaos. Quantum mechanically, we look at Husimi plots, and also use the quantum web, the technique primarily used in spin systems so far, to try to see differences in quantum manifestations of soft and hard chaos. copyright 1999 The American Physical Society

  8. Design rules for piping: Plastic stability of straight parts under level D loadings

    International Nuclear Information System (INIS)

    Touboul, F.; Ben Djidia, M.; Acker, D.

    1989-01-01

    Design rules for piping, elaborated for Fast Breeder Reactors, are based on analysis performed for Pressure Water Reactors. Interpretation of largely diversified straight parts tests, enable us to validate and improve existing rules and to propose a more suitable formula. Design rules for piping appear to be non conservative for austenitic thin tubes in bending or torsion. By introducing a B 2 coefficient, geometrically dependent, the gap between thin and thick tubes may be withheld. Conservatism of rules can be ensured by considering the allowable stress defined by ASME, Section III, Appendix F

  9. Linear Motion Systems. A Modular Approach for Improved Straightness Performance

    NARCIS (Netherlands)

    Nijsse, G.J.P.

    2001-01-01

    This thesis deals with straight motion systems. A modular approach has been applied in order to find ways to improve the performance. The main performance parameters that are considered are position accuracy, repeatability and, to a lesser extent, cost. Because of the increasing requirements to

  10. Modeling plasma flow in straight and curved solenoids

    International Nuclear Information System (INIS)

    Boercker, D.B.; Sanders, D.M.; Storer, J.; Falabella, S.

    1991-01-01

    The ''flux-tube'' model originated by Morozov is a very simple and numerically efficient method for simulating ion motion in plasma filters. In order to test its utility as a design tool, we compare the predictions of the model to recent experimental measurements of plasma flow in both straight and curved solenoids

  11. Steam cracking of hydrocarbons 3. Straight-run naphtha

    NARCIS (Netherlands)

    Bajus, M.; Vesely, V.; Leclercq, P.A.; Rijks, J.A.

    1980-01-01

    Steam cracking of straight-run naphtha from Romashkino crude oil was investigated in quartz and stainless steel reactors with a relatively large ratio of Inner surface to volume. The experiments were performed at atmospheric pressure at 780-800 OC for starting ratios of steam to naphtha between 0.5

  12. Setting the Record Straight on "High-Yield" Strategies

    Science.gov (United States)

    Marzano, Robert J.

    2009-01-01

    Widely credited with proposing nine "high-yield" instructional strategies, author Robert J. Marzano sets the record straight about the broader number of strategies identified by the research. He provides a list of 41 strategies and suggests more nuanced ways of using, observing, and evaluating them. (Contains 1 figure.)

  13. The Dugdale solution for two unequal straight cracks weakening

    Indian Academy of Sciences (India)

    A crack arrest model is proposed for an infinite elastic perfectly-plastic plate weakened by two unequal, quasi-static, collinear straight cracks. The Dugdale model solution is obtained for the above problem when the developed plastic zones are subjected to normal cohesive quadratically varying yield point stress. Employing ...

  14. Body image in gay and straight men: a qualitative study.

    Science.gov (United States)

    Morgan, John F; Arcelus, Jon

    2009-11-01

    Recent research has emphasized vulnerability to eating disorders in gay men, with calls for research on causality, cultural factors and focus on a younger age cohort. This study aimed to examine body image and related eating behaviours in younger gay and straight men. Qualitative study using a sample of gay and straight male university students, applying audiotaped and transcribed depth interview subjected to interpretative phenomenological analysis. Fifteen young men (18-24) with a spectrum of sexual orientation (gay, straight and bisexual) agreed to participate. Five dominant categories emerged: body image ideal, external influences, perception of body image, dieting, mechanisms for modification (diet, exercise, cosmetics) and sexual orientation. Health and aesthetic ideals appear less divorced for young men than women, offering some degree of protection from eating disorders. Nonetheless there is widespread body dissatisfaction. Media and social influences are powerful, particularly for single gay men, but the study suggests fewer differences than similarities between gay and straight men. Copyright (c) 2009 John Wiley & Sons, Ltd and Eating Disorders Association.

  15. Stereotactic biopsy of cerebellar lesions: straight versus oblique frame positioning.

    Science.gov (United States)

    Quick-Weller, Johanna; Brawanski, Nina; Dinc, Nazife; Behmanesh, Bedjahn; Kammerer, Sara; Dubinski, Daniel; Seifert, Volker; Marquardt, Gerhard; Weise, Lutz

    2017-10-26

    Biospies of brain lesions with unknown entity are an everyday procedure among many neurosurgical departments. Biopsies can be performed frame-guided or frameless. However, cerebellar lesions are a special entity with a more complex approach. All biopsies in this study were performed stereotactically frame guided. Therefore, only biopsies of cerebellar lesions were included in this study. We compared whether the frame was attached straight versus oblique and we focused on diagnostic yield and complication rate. We evaluated 20 patients who underwent the procedure between 2009 and 2017. Median age was 56.5 years. 12 (60%) Patients showed a left sided lesion, 6 (30%) showed a lesion in the right cerebellum and 2 (10%) patients showed a midline lesion. The stereotactic frame was mounted oblique in 12 (60%) patients and straight in 8 (40%) patients. Postoperative CT scan showed small, clinically silent blood collection in two (10%) of the patients, one (5%) patient showed haemorrhage, which caused a hydrocephalus. He received an external ventricular drain. In both patients with small haemorrhage the frame was positioned straight, while in the patient who showed a larger haemorrhage the frame was mounted oblique. In all patients a final histopathological diagnosis was established. Cerebellar lesions of unknown entity can be accessed transcerebellar either with the stereotactic frame mounted straight or oblique. Also for cerebellar lesions the procedure shows a high diagnostic yield with a low rate of severe complications, which need further treatment.

  16. A Straight-Talk Survival Guide for Colleges

    Science.gov (United States)

    Facione, Peter A.

    2009-01-01

    Times are very tough. The great majority of colleges are looking at 2009 and 2010 and beyond, in anticipation of the deepest budget cuts in more than a generation. But as bad as the financial situation may be, colleges can survive if they take swift and strong emergency action. It is time for some straight talk, starting with the realization that…

  17. A new straight accelerator tube with U diaphragm

    International Nuclear Information System (INIS)

    Liu Jinhong; Lai Weiquan; Deng Yushen; Zhang Jidong

    1994-01-01

    After calculating the potential distribution and the particle trajectories in electrostatic accelerator tubes, a new straight tube with U diaphragm to suppress secondary particles is proposed. It's properties are demonstrated by the high voltage tests and the γ-rays measurements in the accelerator

  18. Cardiorespiratory and metabolic responses during straight and bent knee cycling.

    Science.gov (United States)

    Mandroukas, K; Angelopoulou, N; Christoulas, K; Vrabas, I S

    2000-06-01

    This study examined the influence of knee angle on the cardiorespiratory system loading during submaximal and maximal stationary cycle ergometry. Experimental design and participants: eighteen untrained women (age: 21+/-1.88 years, weight: 57+/-5.75 kg, height: 165+/-5.03 cm, values are mean+/-SD) volunteered as subjects and underwent two-cycle ergometer incremental (Jaeger ER900) tests: 1) straight knee (180 degrees), 2) bent knee (140 degrees). oxygen uptake (VO2), ventilation (VE) and respiratory exchange ratio (RER) were measured continuously during each test using an open circuit spirometry and blood lactate concentration was determined by means of an enzymatic method. Comparing cycling with "straight knee" to cycling with "bent knee" at 50 W, heart rate (HR), V(E) and VO2 were significantly higher (10.6%, 12.5%, 17.8%). At 100 W, blood lactate was significantly lower (10.8%) while VO2 and RER was higher (5.5%, 7.1%). During maximal exercise, the total exercise time was significantly longer (11.2%) and VE, VO2 and HR were significantly higher during cycling with "straight knee" compared to cycling with "bent knee". No significant difference in peak lactate was evident between the two sitting positions. The results of this study indicate that cycling with bent knee requires lower oxygen uptake while pedaling with straight knee is the only way to reach VO2max during cycle testing, since the cardiorespiratory system is fully taxed.

  19. Do pigeons prefer alternatives that include near-hit outcomes?

    Science.gov (United States)

    Stagner, Jessica P; Case, Jacob P; Sticklen, Mary F; Duncan, Amanda K; Zentall, Thomas R

    2015-07-01

    Pigeons show suboptimal choice on a gambling-like task similar to that shown by humans. Humans also show a preference for gambles in which there are near hits (losses that come close to winning). In the present research, we asked if pigeons would show a preference for alternatives with near-hit-like trials. In Experiment 1, we included an alternative that presented a near hit, in which a stimulus associated with reinforcement (a presumed conditioned reinforcer) changed to a stimulus associated with the absence of reinforcement (a presumed conditioned inhibitor). The pigeons tended to avoid this alternative. In Experiment 2, we varied the duration of the presumed conditioned reinforcer (2 vs. 8 s) that changed to a presumed conditioned inhibitor (8 vs. 2 s) and found that the longer the conditioned reinforcer was presented, the more the pigeons avoided it. In Experiment 3, the near-hit alternative involved an ambiguous stimulus for 8 s that changed to a presumed conditioned reinforcer (or a presumed conditioned inhibitor) for 2 s, but the pigeons still avoided it. In Experiment 4, we controlled for the duration of the conditioned reinforcer by presenting it first for 2 s followed by the ambiguous stimulus for 8 s. Once again, the pigeons avoided the alternative with the near-hit trials. In all 4 experiments, the pigeons tended to avoid alternatives that provided near-hit-like trials. We concluded that humans may be attracted to near-hit trials because near-hit trials give them the illusion of control, whereas this does not appear to be a factor for pigeons. (c) 2015 APA, all rights reserved).

  20. A fast DSP-based calorimeter hit scanning system

    International Nuclear Information System (INIS)

    Sekikawa, S.; Arai, I.; Suzuki, A.; Watanabe, A.; Marlow, D.R.; Mindas, C.R.; Wixted, R.L.

    1997-01-01

    A custom made digital signal processor (DSP) based system has been developed to scan calorimeter hits read by a 32-channel FASTBUS waveform recorder board. The scanner system identifies hit calorimeter elements by surveying their discriminated outputs. This information is used to generate a list of addresses, which guides the read-out process. The system is described and measurements of the scan times are given. (orig.)

  1. Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia.

    Science.gov (United States)

    Okolo, Onyemaechi N; Johnson, Ariel C; Yun, Seongseok; Arnold, Stacy J; Anwer, Faiz

    2017-08-01

    Waldenström macroglobulinemia (WM) is a lymphoproliferative lymphoma that is characterized by monoclonal immunoglobulin M (IgM) protein and bone marrow infiltration. Its incidence is rare and rarer still is its ability to transform to a B-cell lymphoma, particularly the aggressive diffuse large B-cell lymphoma, which bodes a poor prognosis. When transformation includes mutations of MYC, BCL-2 and/or BCL-6, it is known as a 'double hit' or 'triple hit' lymphoma respectively. This paper presents a rare case of WM with mutations positive for MYC and BCL2, making it a case of double hit B-cell lymphoplasmacytic lymphoma with plasmatic differentiation without morphological transformation to aggressive histology like DLBCL. The paper also broadens to include discussions on current topics in the classification, diagnosis, possible causes of transformation, and treatment of WM, including transformation to double hit lymphoma. The significance of this case lies in that the presence of double hit lymphoma-like genetic mutations in WM have not been previously described in the literature and potentially such changes are harbinger of extra-nodal presentation, aggressive growth, and possibly poor prognosis, if data from other double-hit lymphoma are extrapolated.

  2. Overview of the HIT-SI3 spheromak experiment

    Science.gov (United States)

    Hossack, A. C.; Jarboe, T. R.; Chandra, R. N.; Morgan, K. D.; Sutherland, D. A.; Everson, C. J.; Penna, J. M.; Nelson, B. A.

    2017-10-01

    The HIT-SI and HIT-SI3 spheromak experiments (a = 23 cm) study efficient, steady-state current drive for magnetic confinement plasmas using a novel method which is ideal for low aspect ratio, toroidal geometries. Sustained spheromaks show coherent, imposed plasma motion and low plasma-generated mode activity, indicating stability. Analysis of surface magnetic fields in HIT-SI indicates large n = 0 and 1 mode amplitudes and little energy in higher modes. Within measurement uncertainties all the n = 1 energy is imposed by the injectors, rather than being plasma-generated. The fluctuating field imposed by the injectors is sufficient to sustain the toroidal current through dynamo action whereas the plasma-generated field is not (Hossack et al., Phys. Plasmas, 2017). Ion Doppler spectroscopy shows coherent, imposed plasma motion inside r 10 cm in HIT-SI and a smaller volume of coherent motion in HIT-SI3. Coherent motion indicates the spheromak is stable and a lack of plasma-generated n = 1 energy indicates the maximum q is maintained below 1 for stability during sustainment. In HIT-SI3, the imposed mode structure is varied to test the plasma response (Hossack et al., Nucl. Fusion, 2017). Imposing n = 2, n = 3, or large, rotating n = 1 perturbations is correlated with transient plasma-generated activity. Work supported by the U.S. Department of Energy, Office of Science, Office of Fusion Energy Sciences, under Award Number DE-FG02-96ER54361.

  3. Verbs in the lexicon: Why is hitting easier than breaking?

    Science.gov (United States)

    McKoon, Gail; Love, Jessica

    2011-11-01

    Adult speakers use verbs in syntactically appropriate ways. For example, they know implicitly that the boy hit at the fence is acceptable but the boy broke at the fence is not. We suggest that this knowledge is lexically encoded in semantic decompositions. The decomposition for break verbs (e.g. crack, smash) is hypothesized to be more complex than that for hit verbs (e.g. kick, kiss). Specifically, the decomposition of a break verb denotes that "an entity changes state as the result of some external force" whereas the decomposition for a hit verb denotes only that "an entity potentially comes in contact with another entity." In this article, verbs of the two types were compared in a lexical decision experiment - Experiment 1 - and they were compared in sentence comprehension experiments with transitive sentences (e.g. the car hit the bicycle and the car broke the bicycle) - Experiments 2 and 3. In Experiment 1, processing times were shorter for the hit than the break verbs and in Experiments 2 and 3, processing times were shorter for the hit sentences than the break sentences, results that are in accord with the complexities of the postulated semantic decompositions.

  4. Improving the Lives of Students, Gay and Straight Alike: Gay-Straight Alliances and the Role of School Psychologists

    Science.gov (United States)

    Murphy, Heather Elise

    2012-01-01

    Lesbian, gay, bisexual, and transgender (LGBT) students face many risk factors every day when they enter their school's door. These students often fear for their safety at school, are victimized, have academic difficulties, suffer from issues with their identity development, and are at risk for suicide. School-based Gay-Straight Alliances (GSAs)…

  5. Patterns of Hits to the Nearshore from a Major Fairway in the Gulf of Finland

    Science.gov (United States)

    Viikmae, B.; Soomere, T.

    2012-04-01

    The Baltic Sea hosts one of the heaviest ship traffic in the world. Although relatively small in size, still up to 15% of the world's cargo is transported along its numerous fairways. The largest threat to the environment is oil transportation that has increased more than by a factor of two in 2000-2008 and a 40% increase is expected by the year 2015. One of the major marine highways in the European waters enters the Baltic Sea through the Danish Straits, crosses the Baltic Proper and stretches through the Gulf of Finland to Saint Petersburg. An area that is highly vulnerable to ship pollution is the nearshore that usually has the largest ecological value. While the probability of coastal pollution for open ocean coasts can be reduced by shifting ship routes farther offshore, the problem for narrow bays, like the Gulf of Finland, is how to minimize the probability of hitting any of the coasts. To a certain extent, light can be shed to this problem by means of quantification of the offshore areas in terms of their ability to serve a danger to coastal environment if pollution would happen in these areas. A convenient way to address this problem is to use statistical analysis of a large number of Lagrangian trajectories of test particles representing the potential pollution and passively carried by surface currents. In this paper, we make and attempt to quantify the link between potential sources of pollution along an existing fairway and the sections of the coast reached by current-driven pollution. The problem is analysed by means of considering hits to the nearshore from a major fairway in the Gulf of Finland and by making sure whether certain parts of the coast are hit by pollution particles most frequently and whether or not these pollution particles stem from certain specific parts of the fairway. Trajectories are simulated in the Gulf of Finland by placing tracers among a line that follows one of the major fairways from the Baltic Proper to Saint Petersburg

  6. Single-hit mechanism of tumour cell killing by radiation.

    Science.gov (United States)

    Chapman, J D

    2003-02-01

    To review the relative importance of the single-hit mechanism of radiation killing for tumour response to 1.8-2.0 Gy day(-1) fractions and to low dose-rate brachytherapy. Tumour cell killing by ionizing radiation is well described by the linear-quadratic equation that contains two independent components distinguished by dose kinetics. Analyses of tumour cell survival curves that contain six or more dose points usually provide good estimates of the alpha- and beta-inactivation coefficients. Superior estimates of tumour cell intrinsic radiosensitivity are obtained when synchronized populations are employed. The characteristics of single-hit inactivation of tumour cells are reviewed and compared with the characteristics of beta-inactivation. Potential molecular targets associated with single-hit inactivation are discussed along with strategies for potentiating cell killing by this mechanism. The single-hit mechanism of tumour cell killing shows no dependence on dose-rate and, consequently, no evidence of sublethal damage repair. It is uniquely potentiated by high linear-energy-transfer radiation, exhibits a smaller oxygen enhancement ratio and exhibits a larger indirect effect by hydroxyl radicals than the beta-mechanism. alpha-inactivation coefficients vary slightly throughout interphase but mitotic cells exhibit extremely high alpha-coefficients in the range of those observed for lymphocytes and some repair-deficient cells. Evidence is accumulating to suggest that chromatin in compacted form could be a radiation-hypersensitive target associated with single-hit radiation killing. Analyses of tumour cell survival curves demonstrate that it is the single-hit mechanism (alpha) that determines the majority of cell killing after doses of 2Gy and that this mechanism is highly variable between tumour cell lines. The characteristics of single-hit inactivation are qualitatively and quantitatively distinct from those of beta-inactivation. Compacted chromatin in tumour cells

  7. 75 FR 21629 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2010-04-26

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Standards Committee's Workgroups: Clinical Operations Vocabulary... developed by the HIT Policy Committee. Date and Time: The HIT Standards Committee Workgroups will hold the...

  8. 76 FR 46297 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... developed by the HIT Policy Committee. Date and Time: The HIT Standards Committee Workgroups will hold the...

  9. 77 FR 66617 - HIT Policy and Standards Committees; Workgroup Application Database

    Science.gov (United States)

    2012-11-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy and Standards Committees; Workgroup Application... of New ONC HIT FACA Workgroup Application Database. The Office of the National Coordinator (ONC) has.... Name of Committees: HIT Standards Committee and HIT Policy Committee. General Function of the...

  10. Development and formative evaluation of the e-Health Implementation Toolkit (e-HIT

    Directory of Open Access Journals (Sweden)

    Mair Frances

    2010-10-01

    Full Text Available Abstract Background The use of Information and Communication Technology (ICT or e-Health is seen as essential for a modern, cost-effective health service. However, there are well documented problems with implementation of e-Health initiatives, despite the existence of a great deal of research into how best to implement e-Health (an example of the gap between research and practice. This paper reports on the development and formative evaluation of an e-Health Implementation Toolkit (e-HIT which aims to summarise and synthesise new and existing research on implementation of e-Health initiatives, and present it to senior managers in a user-friendly format. Results The content of the e-HIT was derived by combining data from a systematic review of reviews of barriers and facilitators to implementation of e-Health initiatives with qualitative data derived from interviews of "implementers", that is people who had been charged with implementing an e-Health initiative. These data were summarised, synthesised and combined with the constructs from the Normalisation Process Model. The software for the toolkit was developed by a commercial company (RocketScience. Formative evaluation was undertaken by obtaining user feedback. There are three components to the toolkit - a section on background and instructions for use aimed at novice users; the toolkit itself; and the report generated by completing the toolkit. It is available to download from http://www.ucl.ac.uk/pcph/research/ehealth/documents/e-HIT.xls Conclusions The e-HIT shows potential as a tool for enhancing future e-Health implementations. Further work is needed to make it fully web-enabled, and to determine its predictive potential for future implementations.

  11. Straight-Line Target Tracking for Unmanned Surface Vehicles

    Directory of Open Access Journals (Sweden)

    Morten Breivik

    2008-10-01

    Full Text Available This paper considers the subject of straight-line target tracking for unmanned surface vehicles (USVs. Target-tracking represents motion control scenarios where no information about the target behavior is known in advance, i.e., the path that the target traverses is not defined apriori. Specifically, this work presents the design of a motion control system which enables an underactuated USV to track a target that moves in a straight line at high speed. The motion control system employs a guidance principle originally developed for interceptor missiles, as well as a novel velocity controller inspired by maneuverability and agility concepts found in fighter aircraft literature. The performance of the suggested design is illustrated through full-scale USV experiments in the Trondheimsfjord.

  12. Three-Axis Ground Reaction Force Distribution during Straight Walking.

    Science.gov (United States)

    Hori, Masataka; Nakai, Akihito; Shimoyama, Isao

    2017-10-24

    We measured the three-axis ground reaction force (GRF) distribution during straight walking. Small three-axis force sensors composed of rubber and sensor chips were fabricated and calibrated. After sensor calibration, 16 force sensors were attached to the left shoe. The three-axis force distribution during straight walking was measured, and the local features of the three-axis force under the sole of the shoe were analyzed. The heel area played a role in receiving the braking force, the base area of the fourth and fifth toes applied little vertical or shear force, the base area of the second and third toes generated a portion of the propulsive force and received a large vertical force, and the base area of the big toe helped move the body's center of mass to the other foot. The results demonstrate that measuring the three-axis GRF distribution is useful for a detailed analysis of bipedal locomotion.

  13. Penerapan Metode Straight Selection pada Sistem Parkir Universitas Bina Nusantara

    OpenAIRE

    Maharani, Mega; Merlina, Nita

    2014-01-01

    The parking information System is designed to develop the current system that has been employed at BINA NUSANTARA University. Currently, the parking system is limited only recording the police number and they are still manually looking for the available parking area. The system implements straight selection sorting data method, also known as the smallest number search method to determine the available parking location. Parking area will be automatically printed at parking ticket, thus the dri...

  14. Youth Empowerment and High School Gay-Straight Alliances

    OpenAIRE

    Russell, Stephen T.; Muraco, Anna; Subramaniam, Aarti; Laub, Carolyn

    2009-01-01

    In the field of positive youth development programs, “empowerment” is used interchangeably with youth activism, leadership, civic participation and self-efficacy. However, few studies have captured what empowerment means to young people in diverse contexts. This article explores how youth define and experience empowerment in youth-led organizations characterized by social justice goals: high school Gay-Straight Alliances (GSAs). Through focus group interviews, fifteen youth leaders of GSAs fr...

  15. Faller Classification in Older Adults Using Wearable Sensors Based on Turn and Straight-Walking Accelerometer-Based Features.

    Science.gov (United States)

    Drover, Dylan; Howcroft, Jennifer; Kofman, Jonathan; Lemaire, Edward D

    2017-06-07

    Faller classification in elderly populations can facilitate preventative care before a fall occurs. A novel wearable-sensor based faller classification method for the elderly was developed using accelerometer-based features from straight walking and turns. Seventy-six older individuals (74.15 ± 7.0 years), categorized as prospective fallers and non-fallers, completed a six-minute walk test with accelerometers attached to their lower legs and pelvis. After segmenting straight and turn sections, cross validation tests were conducted on straight and turn walking features to assess classification performance. The best "classifier model-feature selector" combination used turn data, random forest classifier, and select-5-best feature selector (73.4% accuracy, 60.5% sensitivity, 82.0% specificity, and 0.44 Matthew's Correlation Coefficient (MCC)). Using only the most frequently occurring features, a feature subset (minimum of anterior-posterior ratio of even/odd harmonics for right shank, standard deviation (SD) of anterior left shank acceleration SD, SD of mean anterior left shank acceleration, maximum of medial-lateral first quartile of Fourier transform (FQFFT) for lower back, maximum of anterior-posterior FQFFT for lower back) achieved better classification results, with 77.3% accuracy, 66.1% sensitivity, 84.7% specificity, and 0.52 MCC score. All classification performance metrics improved when turn data was used for faller classification, compared to straight walking data. Combining turn and straight walking features decreased performance metrics compared to turn features for similar classifier model-feature selector combinations.

  16. 49 CFR Appendix A to Part 1035 - Uniform Straight Bill of Lading

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Uniform Straight Bill of Lading A Appendix A to Part 1035 Transportation Other Regulations Relating to Transportation (Continued) SURFACE... Appendix A to Part 1035—Uniform Straight Bill of Lading Uniform Straight Bill of Lading Original—Not...

  17. 26 CFR 7.57(d)-1 - Election with respect to straight line recovery of intangibles.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Election with respect to straight line recovery... ACT OF 1976 § 7.57(d)-1 Election with respect to straight line recovery of intangibles. (a) Purpose... Tax Reform Act of 1976. Under this election taxpayers may use cost depletion to compute straight line...

  18. Influence of Running on Pistol Shot Hit Patterns.

    Science.gov (United States)

    Kerkhoff, Wim; Bolck, Annabel; Mattijssen, Erwin J A T

    2016-01-01

    In shooting scene reconstructions, risk assessment of the situation can be important for the legal system. Shooting accuracy and precision, and thus risk assessment, might be correlated with the shooter's physical movement and experience. The hit patterns of inexperienced and experienced shooters, while shooting stationary (10 shots) and in running motion (10 shots) with a semi-automatic pistol, were compared visually (with confidence ellipses) and statistically. The results show a significant difference in precision (circumference of the hit patterns) between stationary shots and shots fired in motion for both inexperienced and experienced shooters. The decrease in precision for all shooters was significantly larger in the y-direction than in the x-direction. The precision of the experienced shooters is overall better than that of the inexperienced shooters. No significant change in accuracy (shift in the hit pattern center) between stationary shots and shots fired in motion can be seen for all shooters. © 2015 American Academy of Forensic Sciences.

  19. Recent results from the HIT-II and HIT-SI helicity injection current drive experiments

    International Nuclear Information System (INIS)

    Jarboe, T.R.; Hamp, W.T.; Izzo, V.A.; Nelson, B.A.; O'Neill, R.G.; Raman, R.; Redd, A.J.; Sieck, P.E.; Smith, R.J.

    2005-01-01

    Three important results are reported. 1) CHI startup has produced 100 kA of closed current without using poloidal field (PF) coils or any transformer action. The initial equilibrium is then driven to 240 kA with a 3 V transformer loop voltage, indicating high quality plasma. 2) For the first time CHI alone has produced toroidal currents (350 kA) that far exceed q a I inj , and with I p /I tf as high as 1.2. The key to these new results appears to be having the toroidal field small enough that relaxation will occur. 3) The steady inductive helicity injection spheromak experiment has operated at 5 kHz for 6 ms with current amplitudes up to 11 kA in each injector. The helicity injection rate is nearly constant with the ExB flow always into the plasma and not into the walls. NIMROD simulations of HIT-SI show a buildup of spheromak fields. (author)

  20. Multi-hit time-to-amplitude CAMAC module (MTAC)

    International Nuclear Information System (INIS)

    Kang, H.

    1980-10-01

    A Multi-Hit Time-to-Amplitude Module (MTAC) for the SLAC Mark III drift chamber system has been designed to measure drift time by converting time-proportional chamber signals into analog levels, and converting the analog data by slow readout via a semi-autonomous controller in a CAMAC crate. The single width CAMAC module has 16 wire channels, each with a 4-hit capacity. An externally generated common start initiates an internal precision ramp voltage which is then sampled using a novel shift register gating scheme and CMOS sampling switches. The detailed design and performance specifications are described

  1. Does ′heparin-induced thrombocytopenia′ hit our minds?

    Directory of Open Access Journals (Sweden)

    Arun R Thangavel

    2016-01-01

    Full Text Available Unfractionated heparin is a widely used drug to prevent deep vein thrombosis and pulmonary emboli in patients at risk. With the advent of newer anticoagulants having lesser side effects, its use has diminished but not out of service. Here, we report a case of deep venous thrombosis, in a patient on prophylactic dose of heparin, which was later found to be a manifestation of heparin-induced thrombocytopenia (HIT. Thrombosis in the presence of heparin prophylaxis should be considered as HIT rather than a failure of anticoagulation.

  2. Direct determination of the hit locations from experimental HPGe pulses

    Energy Technology Data Exchange (ETDEWEB)

    Désesquelles, P., E-mail: Pierre.Desesquelles@in2p3.fr [Univ. Paris-Sud, CSNSM CNRS/IN2P3, 15 rue G. Clémenceau, 91405 Orsay (France); Boston, A.J.; Boston, H.C.; Cresswell, J.R.; Dimmock, M.R. [Oliver Lodge Laboratory, The University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom); Lazarus, I.H. [STFC Daresbury Laboratory, Daresbury, Warrington WA4 4AD (United Kingdom); Ljungvall, J. [Univ. Paris-Sud, CSNSM CNRS/IN2P3, 15 rue G. Clémenceau, 91405 Orsay (France); Nelson, L. [Oliver Lodge Laboratory, The University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom); Nga, D.-T. [Univ. Paris-Sud, CSNSM CNRS/IN2P3, 15 rue G. Clémenceau, 91405 Orsay (France); Nolan, P.J.; Rigby, S.V. [Oliver Lodge Laboratory, The University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom); Simpson, J. [STFC Daresbury Laboratory, Daresbury, Warrington WA4 4AD (United Kingdom); Van-Oanh, N.-T. [Univ. Paris-Sud, LCP UMR8000 CNRS, 15 rue G. Clémenceau, 91405 Orsay (France)

    2013-11-21

    The gamma-tracking technique optimises the determination of the energy and emission angle of gamma-rays detected by modern segmented HPGe detectors. This entails the determination, using the delivered pulse shapes, of the interaction points of the gamma-ray within the crystal. The direct method presented here allows the localisation of the hits using only a large sample of pulses detected in the actual operating conditions. No external crystal scanning system or pulse shape simulation code is needed. In order to validate this method, it is applied to sets of pulses obtained using the University of Liverpool scanning system. The hit locations are determined by the method with good precision.

  3. Possilibity of estimating payoff matrix from model for hit phenomena

    International Nuclear Information System (INIS)

    Ishii, Akira; Sakaidani, Shota; Iwanaga, Saori

    2016-01-01

    The conflicts of topics on social media is considered using an extended mathematical model based on the mathematical model for hit phenomena that has been used to analyze entertainment hits. The social media platform used in this study was blog. The calculation results shows examples of strong conflict, weak conflict, and no conflict cases. Since the conflict of two topics can be considered in the framework of game theory, the results can be used to determine each matrix element of the payoff matrix of game theory.

  4. Hit Identification and Optimization in Virtual Screening: Practical Recommendations Based Upon a Critical Literature Analysis

    Science.gov (United States)

    Zhu, Tian; Cao, Shuyi; Su, Pin-Chih; Patel, Ram; Shah, Darshan; Chokshi, Heta B.; Szukala, Richard; Johnson, Michael E.; Hevener, Kirk E.

    2013-01-01

    A critical analysis of virtual screening results published between 2007 and 2011 was performed. The activity of reported hit compounds from over 400 studies was compared to their hit identification criteria. Hit rates and ligand efficiencies were calculated to assist in these analyses and the results were compared with factors such as the size of the virtual library and the number of compounds tested. A series of promiscuity, drug-like, and ADMET filters were applied to the reported hits to assess the quality of compounds reported and a careful analysis of a subset of the studies which presented hit optimization was performed. This data allowed us to make several practical recommendations with respect to selection of compounds for experimental testing, defining hit identification criteria, and general virtual screening hit criteria to allow for realistic hit optimization. A key recommendation is the use of size-targeted ligand efficiency values as hit identification criteria. PMID:23688234

  5. Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis.

    Science.gov (United States)

    Zhu, Tian; Cao, Shuyi; Su, Pin-Chih; Patel, Ram; Shah, Darshan; Chokshi, Heta B; Szukala, Richard; Johnson, Michael E; Hevener, Kirk E

    2013-09-12

    A critical analysis of virtual screening results published between 2007 and 2011 was performed. The activity of reported hit compounds from over 400 studies was compared to their hit identification criteria. Hit rates and ligand efficiencies were calculated to assist in these analyses, and the results were compared with factors such as the size of the virtual library and the number of compounds tested. A series of promiscuity, druglike, and ADMET filters were applied to the reported hits to assess the quality of compounds reported, and a careful analysis of a subset of the studies that presented hit optimization was performed. These data allowed us to make several practical recommendations with respect to selection of compounds for experimental testing, definition of hit identification criteria, and general virtual screening hit criteria to allow for realistic hit optimization. A key recommendation is the use of size-targeted ligand efficiency values as hit identification criteria.

  6. The Theory and Assessment of Spatial Straightness Error Matched New Generation GPS

    International Nuclear Information System (INIS)

    Zhang, X B; Sheng, X L; Jiang, X Q; Li, Z

    2006-01-01

    In order to assess spatial straightness error matched new generation Dimensional Geometrical Product Specification and Verification (GPS), the theory of spatial straightness error assessing is proposed and its advantages are analyzed based on metrology and statistics in this paper. Then, the assessing parameter system is proposed and it is testified in real application comparing to assessment result of the geometric tolerance theory. Statistical parameters of this assessing system post the different characteristics of spatial straightness error, and can reveal the impact of spatial straightness error on the accessory function more roundly to complement the single assessing parameter of geometrical tolerance for straightness error. The statistical spatial straightness tolerance and statistical spatial straightness error proposed in this paper is possible to be applied in evaluation of other error of form, orientation, location and run-out

  7. Do repeated rumble strip hits improve driver alertness?

    NARCIS (Netherlands)

    Watling, C.N.; Akerstedt, T.; Kecklund, L.G.; Anund, A.

    2016-01-01

    Driving while sleepy is associated with increased crash risk. Rumble strips are designed to alert a sleepy or inattentive driver when they deviate outside their driving lane. The current study sought to examine the effects of repeated rumble strip hits on levels of physiological and subjective

  8. Madoff Debacle Hits Colleges and Raises Questions about Trustee Conflicts

    Science.gov (United States)

    Fain, Paul

    2009-01-01

    Several colleges and universities lost millions in the alleged $50-billion Ponzi scheme run by the Wall Street trader Bernard L. Madoff. The losses include institutions' endowment holdings in hedge funds that were invested with Madoff as well as hits taken by supporting foundations and donors. Several foundations that have been active in higher…

  9. The probability of a tornado missile hitting a target

    International Nuclear Information System (INIS)

    Goodman, J.; Koch, J.E.

    1983-01-01

    It is shown that tornado missile transportation is a diffusion Markovian process. Therefore, the Green's function method is applied for the estimation of the probability of hitting a unit target area. This propability is expressed through a joint density of tornado intensity and path area, a probability of tornado missile injection and a tornado missile height distribution. (orig.)

  10. Concentrated Hitting Times of Randomized Search Heuristics with Variable Drift

    DEFF Research Database (Denmark)

    Lehre, Per Kristian; Witt, Carsten

    2014-01-01

    Drift analysis is one of the state-of-the-art techniques for the runtime analysis of randomized search heuristics (RSHs) such as evolutionary algorithms (EAs), simulated annealing etc. The vast majority of existing drift theorems yield bounds on the expected value of the hitting time for a target...

  11. COPD: A stepwise or a hit hard approach?

    Directory of Open Access Journals (Sweden)

    A.J. Ferreira

    2016-07-01

    Full Text Available Current guidelines differ slightly on the recommendations for treatment of Chronic Obstructive Pulmonary Disease (COPD patients, and although there are some undisputed recommendations, there is still debate regarding the management of COPD. One of the hindrances to deciding which therapeutic approach to choose is late diagnosis or misdiagnosis of COPD. After a proper diagnosis is achieved and severity assessed, the choice between a stepwise or “hit hard” approach has to be made. For GOLD A patients the stepwise approach is recommended, whilst for B, C and D patients this remains debatable. Moreover, in patients for whom inhaled corticosteroids (ICS are recommended, a step-up or “hit hard” approach with triple therapy will depend on the patient's characteristics and, for patients who are being over-treated with ICS, ICS withdrawal should be performed, in order to optimize therapy and reduce excessive medications.This paper discusses and proposes stepwise, “hit hard”, step-up and ICS withdrawal therapeutic approaches for COPD patients based on their GOLD group. We conclude that all approaches have benefits, and only a careful patient selection will determine which approach is better, and which patients will benefit the most from each approach. Keywords: COPD, Stepwise, Hit hard, Step-up, ICS withdrawal, Bronchodilators, ICS

  12. Biophysics: for HTS hit validation, chemical lead optimization, and beyond.

    Science.gov (United States)

    Genick, Christine C; Wright, S Kirk

    2017-09-01

    There are many challenges to the drug discovery process, including the complexity of the target, its interactions, and how these factors play a role in causing the disease. Traditionally, biophysics has been used for hit validation and chemical lead optimization. With its increased throughput and sensitivity, biophysics is now being applied earlier in this process to empower target characterization and hit finding. Areas covered: In this article, the authors provide an overview of how biophysics can be utilized to assess the quality of the reagents used in screening assays, to validate potential tool compounds, to test the integrity of screening assays, and to create follow-up strategies for compound characterization. They also briefly discuss the utilization of different biophysical methods in hit validation to help avoid the resource consuming pitfalls caused by the lack of hit overlap between biophysical methods. Expert opinion: The use of biophysics early on in the drug discovery process has proven crucial to identifying and characterizing targets of complex nature. It also has enabled the identification and classification of small molecules which interact in an allosteric or covalent manner with the target. By applying biophysics in this manner and at the early stages of this process, the chances of finding chemical leads with novel mechanisms of action are increased. In the future, focused screens with biophysics as a primary readout will become increasingly common.

  13. Markov chains with quasitoeplitz transition matrix: first zero hitting

    Directory of Open Access Journals (Sweden)

    Alexander M. Dukhovny

    1989-01-01

    Full Text Available This paper continues the investigation of Markov Chains with a quasitoeplitz transition matrix. Generating functions of first zero hitting probabilities and mean times are found by the solution of special Riemann boundary value problems on the unit circle. Duality is discussed.

  14. First hitting probabilities for semi markov chains and estimation

    DEFF Research Database (Denmark)

    Georgiadis, Stylianos

    2017-01-01

    We first consider a stochastic system described by an absorbing semi-Markov chain with finite state space and we introduce the absorption probability to a class of recurrent states. Afterwards, we study the first hitting probability to a subset of states for an irreducible semi-Markov chain...

  15. Assessing the lipophilicity of fragments and early hits

    Science.gov (United States)

    Mortenson, Paul N.; Murray, Christopher W.

    2011-07-01

    A key challenge in many drug discovery programs is to accurately assess the potential value of screening hits. This is particularly true in fragment-based drug design (FBDD), where the hits often bind relatively weakly, but are correspondingly small. Ligand efficiency (LE) considers both the potency and the size of the molecule, and enables us to estimate whether or not an initial hit is likely to be optimisable to a potent, druglike lead. While size is a key property that needs to be controlled in a small molecule drug, there are a number of additional properties that should also be considered. Lipophilicity is amongst the most important of these additional properties, and here we present a new efficiency index (LLEAT) that combines lipophilicity, size and potency. The index is intuitively defined, and has been designed to have the same target value and dynamic range as LE, making it easily interpretable by medicinal chemists. Monitoring both LE and LLEAT should help both in the selection of more promising fragment hits, and controlling molecular weight and lipophilicity during optimisation.

  16. Straight spinning cosmic strings in Brans-Dicke gravity

    Science.gov (United States)

    Dos Santos, S. Mittmann; da Silva, J. M. Hoff; Cindra, J. L.

    2018-03-01

    An exact solution of straight spinning cosmic strings in Brans-Dicke theory of gravitation is presented. The possibility of the existence of closed time-like curves around these cosmic strings is analyzed. Furthermore, the stability about the formation of the topological defect discussed here is checked. It is shown that the existence of a suitable choice for the integration constants in which closed time-like curves are not allowed. We also study the (im)possibility of using the obtained spacetime in the rotational curves problem.

  17. Gamma-ray streaming in straight pipes and bent ducts

    International Nuclear Information System (INIS)

    Eid, M.; Diop, C.M.; Nimal, J.C.

    1985-04-01

    An important shielding problem is the gamma-ray streaming through voids. These problems are encountered in the reactors and reprocessing plants. A Monte Carlo method has been choosed as one of the most powerful technics to solve this kind of problems. Here in that frame, a biasing system which is adapted for two types of geometries is proposed: straight pipes and bent ducts. A code has been written applying this technique. The numerical results obained show the efficiency and the very good economy of the method proposed. It is hoped to extend the method to deal with more complex geometries and polykinetic situation as well

  18. Evaluating the Subjective Straight Ahead Before and After Spaceflight

    Science.gov (United States)

    Campbell, D. J.; Wood, S. J.; Reschke, M. F.; Clement, G.

    2017-01-01

    This joint European Space Agency (ESA) - NASA study will address adaptive changes in spatial orientation related to the subjective straight ahead and the use of a vibrotactile sensory aid to reduce perceptual errors. The study will be conducted before and after long duration expeditions to the International Space Station (ISS) to examine how spatial processing of target location is altered following exposure to microgravity. This study addresses the sensorimotor research gap to "determine the changes in sensorimotor function over the course of a mission and during recovery after landing."

  19. Secondary Flow Phenomena in Rotating Radial Straight Pipes

    OpenAIRE

    Cheng, K. C.; Wang, Liqiu

    1995-01-01

    Flow visualization results for secondary flow phenomena near the exit of a rotating radial-axis straight pipe (length ࡁ = 82 cm, inside diameter d = 3.81 cm, ࡁ/d 21.52) are presented to study the stabilizing (relaminarization) and destabilizing (early transition from laminar to turbulent flow) effects of Coriolis forces for Reynolds numbers Re = 500 ∼ 4,500 and rotating speeds n = 0 ∼ 200 rpm. The flow visualization was realised by smoke injection method. The main features of the trans...

  20. Nedley Depression Hit Hypothesis: Identifying Depression and Its Causes.

    Science.gov (United States)

    Nedley, Neil; Ramirez, Francisco E

    2016-11-01

    Depression is often diagnosed using the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria. We propose how certain lifestyle choices and non-modifiable factors can predict the development of depression. We identified 10 cause categories (hits or "blows" to the brain) and theorize that four or more active hits could trigger a depression episode. Methods. A sample of 4271 participants from our community-based program (70% female; ages 17-94 years) was assessed at baseline and at the eighth week of the program using a custom test. Ten cause categories were examined as predictors of depression are (1) Genetic, (2)Developmental, (3)Lifestyle, (4)Circadian Rhythm, (5)Addiction, (6)Nutrition, (7)Toxic, (8)Social/Complicated Grief, (9)Medical Condition, and (10)Frontal Lobe. Results. The relationship between the DSM-5 score and a person having four hits categories in the first program week showed a sensitivity of 89.98 % (95% CI: 89.20 % - 90.73%), specificity 48.84% (CI 45.94-51.75) and Matthew Correlation Coefficient (MCC) .41 . For the eight-week test, the results showed a sensitivity 83.6% (CI 81.9-85.5), specificity 53.7% (CI 51.7-55.6) and MCC .38. Overall, the hits that improved the most from baseline after the eighth week were: Nutrition (47%), Frontal lobe (36%), Addiction (24%), Circadian rhythm (24%), Lifestyle (20%), Social (12%) and Medical (10%). Conclusions. The Nedley four-hit hypothesis seems to predict a depressive episode and correlates well with the DSM-5 criteria with good sensitivity and MCC but less specificity. Identifying these factors and applying lifestyle therapies could play an important role in the treatment of depressed individuals.

  1. Straight and Curved Path Walking Among Older Adults in Primary Care: Associations With Fall-Related Outcomes.

    Science.gov (United States)

    Welch, Sarah A; Ward, Rachel E; Kurlinski, Laura A; Kiely, Dan K; Goldstein, Richard; VanSwearingen, Jessie; Brach, Jennifer S; Bean, Jonathan F

    2016-08-01

    Most falls among community-dwelling older adults occur while walking. Simple walking tests that require little resources and can be interpreted quickly are advocated as useful screening tools for fall prone patients. To investigate 2 clinically feasible walking tests consisting of straight- and curved-path walking and examine their associations with history of previous falls and fall-related outcomes among community-living older adults. A cross-sectional analysis was performed on baseline data from a longitudinal cohort study. Participants were recruited through primary care practices. Participants included 428 primary care patients ≥65 years of age at risk for mobility decline. Participants had a median age of 76.5 years, 67.8% were women, and 82.5% were white. Straight-path walking performance was measured as the time needed to walk a 4-meter straight path at usual pace from standstill using a stopwatch (timed to 0.1 second). Curved-path walking performance was timed while participants walked from standstill in a figure-of-8 pattern around two cones placed 5 feet apart. Multivariable negative binomial regression analyses were performed to assess the relationship between straight-path walking or curved-path walking and self-reported history of number of falls. For fall-related injuries, and fall-related hospitalizations, logistic regression models were used. In the fully adjusted model, an increase of 1 second in straight path walking time was associated with 26% greater rate of falls (rate ratio 1.26, 95% confidence interval 1.10-1.45). An increase in curved-path walking time was associated with 8% greater rate of falls (rate ratio 1.08, 95% confidence interval = 1.03-1.14). Neither walk test was associated with history of fall-related injuries or hospitalizations. Poor performance on straight- and curved-path walking performance was associated with a history of greater fall rates in the previous year but not with a history of fall-related injuries or

  2. Safeguards and security benefits of project straight-line

    International Nuclear Information System (INIS)

    Jaeger, C.D.; Waddoups, I.G.

    1995-01-01

    As a result of a number of events the inventory of fissile materials no longer in nuclear weapons in the United States is increasing. This has led to a growing concern regarding the potential for theft and/or diversion and accountability of this material. Straight-Line is a project whose purpose is to demonstrate a site-independent system to monitor stored nuclear material (e.g. plutonium) and integrate the collection, processing and dissemination of information regarding this material. Safeguards and security (S ampersand S) goals of this project include data transfer of information on nuclear material to appropriate users to enhance S ampersand S, continuous on-line accountability, reduction of hands-on access to nuclear materials, incorporation of information security technologies, and early detection of tampering or unauthorized material movement. This paper addresses threat considerations, S ampersand S requirements, S ampersand S objectives, and issues for the Straight-Line project. S ampersand S features and benefits of this project are discussed with respect to existing item monitoring systems and/or other material tracking systems being developed

  3. Excessive deformation and failure of straight parts and elbows

    International Nuclear Information System (INIS)

    Touboul, F.; Acker, D.

    1991-01-01

    The design rules for LMFBRs must cover the ranges of loading types and geometries wider than PWR Design Codes. Steam pipework does not differ between two reactor systems, but as far as sodium piping is concerned, usual PWR criteria may not be adequate. The LMFBR sodium piping is operated at high temperature and low pressure level. Moreover, these peculiar loadings require the geometrical characteristics completely different in the fact that the piping must be flexible but need not to be thick. For such piping components, the ultimate behavior depends much on the geometry. 170 experimental results on straight parts and 95 results on elbows were investigated. As for elbows, half of the tests were performed under in-plane closing moment. On the analysis of straight pipes and elbows, the experiments and the proposed expressions for the evaluation of collapse and instability moments are described, respectively. The application of the present study to the design rules and the criteria for various loading conditions are reported. It is difficult to experimentally distinguish between plastic instability and buckling. (K.I.)

  4. An in-situ measuring method for planar straightness error

    Science.gov (United States)

    Chen, Xi; Fu, Luhua; Yang, Tongyu; Sun, Changku; Wang, Zhong; Zhao, Yan; Liu, Changjie

    2018-01-01

    According to some current problems in the course of measuring the plane shape error of workpiece, an in-situ measuring method based on laser triangulation is presented in this paper. The method avoids the inefficiency of traditional methods like knife straightedge as well as the time and cost requirements of coordinate measuring machine(CMM). A laser-based measuring head is designed and installed on the spindle of a numerical control(NC) machine. The measuring head moves in the path planning to measure measuring points. The spatial coordinates of the measuring points are obtained by the combination of the laser triangulation displacement sensor and the coordinate system of the NC machine, which could make the indicators of measurement come true. The method to evaluate planar straightness error adopts particle swarm optimization(PSO). To verify the feasibility and accuracy of the measuring method, simulation experiments were implemented with a CMM. Comparing the measurement results of measuring head with the corresponding measured values obtained by composite measuring machine, it is verified that the method can realize high-precise and automatic measurement of the planar straightness error of the workpiece.

  5. Straight versus tortuous retinal arteries in relation to blood pressure and genetics

    DEFF Research Database (Denmark)

    Taarnhøj, N C B B; Munch, I C; Sander, B

    2008-01-01

    dizygotic same-sex healthy twin pairs, aged 20 to 46 years, who were characterised by determination of retinal vessel diameters, arterial blood pressure, blood glucose, body mass index, smoking habits and retinal arterial tortuosity, using a three-level grading scale (straight, wavy, tortuous). Heritability......BACKGROUND/AIMS: To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity and the association between tortuosity and various health indices in healthy young to middle-aged persons. METHODS: This cross-sectional study included 57 monozygotic and 52...... accounting for the remaining 18% (CI(95 )8, 36%). Increasing values of mean arterial blood pressure and body mass index were both associated with decreasing levels of retinal arterial tortuosity. CONCLUSION: There was a large variation in tortuosity of retinal arteries in these healthy subjects...

  6. A new aeroelastic model for composite rotor blades with straight and swept tips

    Science.gov (United States)

    Yuan, Kuo-An; Friedmann, Peretz P.; Venkatesan, Comandur

    1992-01-01

    An analytical model for predicting the aeroelastic behavior of composite rotor blades with straight and swept tips is presented. The blade is modeled by beam type finite elements along the elastic axis. A single finite element is used to model the swept tip. The nonlinear equations of motion for the finite element model are derived using Hamilton's principle and based on a moderate deflection theory and accounts for: arbitrary cross-sectional shape, pretwist, generally anisotropic material behavior, transverse shears and out-of-plane warping. Numerical results illustrating the effects of tip sweep, anhedral and composite ply orientation on blade aeroelastic behavior are presented. Tip sweep can induce aeroelastic instability by flap-twist coupling. Tip anhedral causes lag-torsion and flap-axial couplings, however, its effects on blade stability is less pronounced than the effect due to sweep. Composite ply orientation has a substantial effect on blade stability.

  7. Insertion device development in the X13 straight of the NSLS X-Ray Ring

    International Nuclear Information System (INIS)

    Stefan, P.M.; Krinsky, S.; Kao, C.C.; Rakowsky, G.; Singh, O.; Solomon, L.

    1997-01-01

    On the NSLS X-Ray Storage Ring, the X13 straight section and beamline have been used for insertion-device-related R and D since 1990. The authors will describe three important projects: The Prototype Small-Gap Undulator (PSGU), the In-Vacuum Undulator (IVUN), and the Time Varying Elliptically Polarized Wiggler (EPW). The PSGU has successfully operated with a vertical aperture of only 3 mm, with minimal reduction in electron beam lifetime. The EPW has successfully run during regular user operations while switching at either 2 Hz or 100 Hz, with no adverse effects on other experiments. The IVUN project is a collaboration between NSLS and Spring-8, and installation is scheduled for May 1997

  8. Identifying and Synchronizing Health Information Technology (HIT) Events from FDA Medical Device Reports.

    Science.gov (United States)

    Kang, Hong; Wang, Frank; Zhou, Sicheng; Miao, Qi; Gong, Yang

    2017-01-01

    Health information technology (HIT) events, a subtype of patient safety events, pose a major threat and barrier toward a safer healthcare system. It is crucial to gain a better understanding of the nature of the errors and adverse events caused by current HIT systems. The scarcity of HIT event-exclusive databases and event reporting systems indicates the challenge of identifying the HIT events from existing resources. FDA Manufacturer and User Facility Device Experience (MAUDE) database is a potential resource for HIT events. However, the low proportion and the rapid evolvement of HIT-related events present challenges for distinguishing them from other equipment failures and hazards. We proposed a strategy to identify and synchronize HIT events from MAUDE by using a filter based on structured features and classifiers based on unstructured features. The strategy will help us develop and grow an HIT event-exclusive database, keeping pace with updates to MAUDE toward shared learning.

  9. The Effect of Scala Tympani Morphology on Basilar Membrane Contact With a Straight Electrode Array: A Human Temporal Bone Study.

    Science.gov (United States)

    Verberne, Juul; Risi, Frank; Campbell, Luke; Chambers, Scott; O'Leary, Stephen

    2017-01-01

    Scala tympani morphology influences the insertion dynamics and intra-scalar position of straight electrode arrays. Hearing preservation is the goal of cochlear implantation with current thin straight electrode arrays. These hug the lateral wall, facilitating full, atraumatic insertions. However, most studies still report some postoperative hearing loss. This study explores the influence of scala tympani morphology on array position relative to the basilar membrane and its possible contribution to postoperative hearing loss. Twenty-six fresh-frozen human temporal bones implanted with a straight electrode array were three-dimensionally reconstructed from micro-photographic histological sections. Insertion depth and the proximity between the array and basilar membrane were recorded. Lateral wall shape was quantified as a curvature ratio. Insertion depths ranged from 233 to 470 degrees. The mean first point of contact between the array and basilar membrane was 185 degrees; arrays tended to remain in contact with the membrane after first contacting it. Eighty-nine and 93% of arrays that reached the upper basal (>240-360 degrees) and second (>360-720 degrees) turns respectively contacted the basilar membrane in these regions. Scalar wall curvature ratio decreased significantly (the wall became steeper) from the basal to second turns. This shift correlated with a reduced distance between the array and basilar membrane. Scala tympani morphology influences the insertion dynamics and intra-scalar position of a straight electrode array. In addition to gross trauma of cochlear structures, contact between the array and basilar membrane and how this impacts membrane function should be considered in hearing preservation cases.

  10. Registration of airborne LiDAR data and aerial images based on straight lines and POS data

    Science.gov (United States)

    Du, Quanye; Xu, Biao; Cao, Hui

    2009-10-01

    This paper presents a registration method which based on straight lines primitive. Firstly, 2D straight lines are extracted from aerial images using Canny operator and straight line fitting. In the similar way, 3D straight lines are extracted from LiDAR range images which derive from laser scanning point cloud. Secondly, 3D straight lines are projected to aerial images using collinearity equations and Position and Orientation System (POS) data. Then the corresponding lines are determined by straight line error. At last, each image's new exterior orientation elements are calculated by generalized point (straight line) photogrammetry.

  11. DEPDC5 takes a second hit in familial focal epilepsy.

    Science.gov (United States)

    Anderson, Matthew P

    2018-04-30

    Loss-of-function mutations in a single allele of the gene encoding DEP domain-containing 5 protein (DEPDC5) are commonly linked to familial focal epilepsy with variable foci; however, a subset of patients presents with focal cortical dysplasia that is proposed to result from a second-hit somatic mutation. In this issue of the JCI, Ribierre and colleagues provide several lines of evidence to support second-hit DEPDC5 mutations in this disorder. Moreover, the authors use in vivo, in utero electroporation combined with CRISPR-Cas9 technology to generate a murine model of the disease that recapitulates human manifestations, including cortical dysplasia-like changes, focal seizures, and sudden unexpected death. This study provides important insights into familial focal epilepsy and provides a preclinical model for evaluating potential therapies.

  12. Hit size effectiveness in relation to the microdosimetric site size

    International Nuclear Information System (INIS)

    Varma, M.N.; Wuu, C.S.; Zaider, M.

    1994-01-01

    This paper examines the effect of site size (that is, the diameter of the microdosimetric volume) on the hit size effectiveness function (HSEF), q(y), for several endpoints relevant in radiation protection. A Bayesian and maximum entropy approach is used to solve the integral equations that determine, given microdosimetric spectra and measured initial slopes, the function q(y). All microdosimetric spectra have been calculated de novo. The somewhat surprising conclusion of this analysis is that site size plays only a minor role in selecting the hit size effectiveness function q(y). It thus appears that practical means (e.g. conventional proportional counters) are already at hand to actually implement the HSEF as a radiation protection tool. (Author)

  13. Tolosa-Hunt Syndrome in Double-Hit Lymphoma

    Directory of Open Access Journals (Sweden)

    Prakash Peddi

    2015-01-01

    Full Text Available Tolosa-Hunt syndrome (THS is a painful condition characterized by hemicranial pain, retroorbital pain, loss of vision, oculomotor nerve paralysis, and sensory loss in distribution of ophthalmic and maxillary division of trigeminal nerve. Lymphomas rarely involve cavernous sinus and simulate Tolosa-Hunt syndrome. Here we present a first case of double-hit B cell lymphoma (DHL relapsing and masquerading as Tolosa-Hunt syndrome. The neurological findings were explained by a lymphomatous infiltration of the right Gasserian ganglion which preceded systemic relapse. As part of this report, the diagnostic criteria for Tolosa-Hunt syndrome and double-hit lymphoma are reviewed and updated treatment recommendations are presented.

  14. Effect of iron catalyst thickness on vertically aligned carbon nanotube forest straightness for CNT-MEMS

    International Nuclear Information System (INIS)

    Moulton, Kellen; Jensen, Brian D; Morrill, Nicholas B; Konneker, Adam M; Vanfleet, Richard R; Allred, David D; Davis, Robert C

    2012-01-01

    This paper examines the effect of iron catalyst thickness on the straightness of growth of carbon nanotubes (CNTs) for microelectromechanical systems fabricated using the CNT-templated-microfabrication (CNT-M) process. SEM images of samples grown using various iron catalyst thicknesses show that both straight sidewalls and good edge definition are achieved using an iron thickness between 7 and 8 nm. Below this thickness, individual CNTs are well aligned, but the sidewalls of CNT forests formed into posts and long walls are not always straight. Above this thickness, the CNT forest sidewalls are relatively straight, but edge definition is poor, with significantly increased sidewall roughness. The proximity of a device or feature to other regions of iron catalyst also affects CNT growth. By using an iron catalyst thickness appropriate for straight growth, and by adding borders of iron around features or devices, a designer can greatly improve straightness of growth for CNT-MEMS. (paper)

  15. Heparin- induced thrombocytopenia (HIT: a case report of CABG patient

    Directory of Open Access Journals (Sweden)

    Alireza Jahangirifard

    2016-08-01

    Full Text Available Heparin- induced thrombocytopenia (HIT is an antibody mediated adverse effect of heparin therapy which is classified into two subtypes, HITI which is non-immune, spontaneously reversible thrombocytopenia and; HITII which is an autoimmune-mediated adverse effect of heparin therapy. In this case report, we described a 65-year old male patient with HITII after coronary artery bypass grafting.Key words: Heparin- induced thrombocytopenia, Heparin- induced thrombosis, coronary artery bypass grafting.

  16. Straight Delegation Issues Concerning Sections 111 and 112 Requirements and Title V

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  17. The Assembly of the LHC Short Straight Sections (SSS) at CERN Project Status and Lessons Learned

    CERN Document Server

    Parma, Vittorio; Dos Santos de Campos, Paulo M; Feitor, Rogerio C; Gandel, Makcim; López, R; Schmidlkofer, Martin; Slits, Ivo

    2005-01-01

    The series production of the LHC SSS has started in the beginning of 2004 and is foreseen to last until end 2006. The production consists in the assembly of 474 cold masses housing superconducting quadrupoles and corrector magnets within their cryostats. 87 cold mass variants, resulting from various combinations of main quadrupole and corrector magnets, have to be assembled in 55 cryostat types, depending on the specific cryogenic and electrical powering schemes required by the collider topology. The assembly activity features the execution of more than 5 km of leak-tight welding of stainless steel and aluminium cryogenic lines, designed for 20-bar pressure, according to high qualification standards and undergoing severe QA inspections. Some 2500 leak detection tests, using He mass spectrometry, are required to check the tightness of the cryogenic circuits. Extensive electrical control work, to check the integrity of the magnet instrumentation and electrical circuits throughout the assembly of the SSS, is als...

  18. 76 FR 46298 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held virtually on August 17, 2011...

  19. 76 FR 55914 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-09-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  20. 77 FR 16035 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-03-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on March 27, 2012, from 9 a.m...

  1. 75 FR 65636 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-10-26

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  2. 76 FR 79684 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-12-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on January 25, 2012, from 9 a...

  3. 76 FR 50734 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-08-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on September 28, 2011, from 9...

  4. 77 FR 2727 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-01-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on February 29, 2012, from 9...

  5. 77 FR 15760 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-03-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on April 18, 2012, from 9 a.m...

  6. 76 FR 46297 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  7. 76 FR 14976 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on April 20, 2011, from 9 a.m...

  8. 76 FR 70455 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-11-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on December 14, 2011, from 9...

  9. 75 FR 5595 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2010-02-03

    ... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Health Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT... Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT Policy Committee...

  10. 76 FR 4352 - Office of the National Coordinator for Health Information Technology; HIT Policy Committee's...

    Science.gov (United States)

    2011-01-25

    ... Technology; HIT Policy Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Policy Committee's Workgroups: Meaningful Use, Privacy & Security Tiger..., implementation specifications, and certification criteria are needed. Date and Time: The HIT Policy Committee...

  11. 76 FR 39109 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-07-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on July 20, 2011, from 9 a.m...

  12. 77 FR 73661 - HIT Standards Committee Advisory Meetings; Notice of Meetings

    Science.gov (United States)

    2012-12-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meetings; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: These meetings will be held on the following dates and...

  13. 76 FR 70454 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-11-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... certification criteria are needed. Date and Time: The HIT Policy Committee Workgroups will hold the following...

  14. 75 FR 57027 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-09-17

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  15. 76 FR 28784 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

  16. 76 FR 28782 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on June 22, 2011, from 9 a.m...

  17. 77 FR 27459 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-05-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on June 20, 2012, from 9 a.m...

  18. 76 FR 22399 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-04-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  19. 76 FR 28784 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  20. 75 FR 29762 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2010-05-27

    ... Technology HIT Policy Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Policy Committee's Workgroups: Meaningful Use, Privacy & Security Policy... specifications, and certification criteria are needed. Date and Time: The HIT Policy Committee Workgroups will...

  1. 76 FR 50736 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-08-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

  2. 77 FR 37408 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-06-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... be open to the public. Name of Committee: HIT Standards Committee. General Function of the Committee... with policies developed by the HIT Policy Committee. Date and Time: The meeting will be held on July 19...

  3. 76 FR 14975 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

  4. 77 FR 22787 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-04-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on May 24, 2012, from 9 a.m...

  5. 77 FR 65691 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-10-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on November 13, 2012, from 9...

  6. 77 FR 50690 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-08-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on September 19, 2012, from 9...

  7. 75 FR 21628 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2010-04-26

    ... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  8. 76 FR 14974 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  9. 76 FR 22396 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-04-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on May 18, 2011, from 9 a.m...

  10. 76 FR 55913 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-09-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: to provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held virtually on October 21, 2011...

  11. 76 FR 50735 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

    Science.gov (United States)

    2011-08-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

  12. 77 FR 60438 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-10-03

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on October 17, 2012, from 9 a...

  13. 75 FR 3906 - Office of the National Coordinator for Health Information Technology; HIT Policy Committee's...

    Science.gov (United States)

    2010-01-25

    ... Technology; HIT Policy Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National... only. Name of Committees: HIT Policy Committee's Workgroups: Meaningful Use, Privacy & Security Policy... specifications, and certification criteria are needed. Date and Time: The HIT Policy Committee Workgroups will...

  14. 77 FR 65690 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-10-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on December 19, 2012, from 9...

  15. 76 FR 9783 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-02-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on March 29, 2011, from 9 a.m...

  16. 77 FR 45353 - HIT Standards Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-07-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee Advisory Meeting; Notice of... public. Name of Committee: HIT Standards Committee. General Function of the Committee: To provide... developed by the HIT Policy Committee. Date and Time: The meeting will be held on August 15, 2012, from 9:00...

  17. 75 FR 42090 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-07-20

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  18. Development of pulsation technique for single ion hit system

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Takuro; Hamano, Tsuyoshi; Hirao, Toshio; Kamiya, Tomihiro [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1996-12-01

    When a high energy heavy ion enters into a substance, high density of ionization and excitement occurrs along its flying trace. Especially, when such an ion enters into a semiconductor cell, a bit inversion called single event is occurred or a phenomenon destroyed element itself on case of the worst is formed. The present semiconductor cell is made in a size of some micron square, as different from its accumulated degree. In order to analyze the single event phenomenon formed by entering ion into such fine region in detail, a technique possible enter heavy ion beam with space resolution under 1 micron to each sample is necessary. In order to develop this technique, a static type high speed beam switch for control of entering a beam into a sample and a single ion detector for detecting entrance of ion into the sample were installed to heavy ion microbeam forming apparatus. The single ion hit system in Takasaki Radiation Chemistry Research Establishment, JAERI succeeded in detection and control technique of the single ion and control of noise due to pulsization and finished development of basic technique of the single ion hit, since now. After today, it is planned to hit actually the single ion onto the sample and evaluate its accuracy. (G.K.)

  19. Effective progression of nuclear magnetic resonance-detected fragment hits.

    Science.gov (United States)

    Eaton, Hugh L; Wyss, Daniel F

    2011-01-01

    Fragment-based drug discovery (FBDD) has become increasingly popular over the last decade as an alternate lead generation tool to HTS approaches. Several compounds have now progressed into the clinic which originated from a fragment-based approach, demonstrating the utility of this emerging field. While fragment hit identification has become much more routine and may involve different screening approaches, the efficient progression of fragment hits into quality lead series may still present a major bottleneck for the broadly successful application of FBDD. In our laboratory, we have extensive experience in fragment-based NMR screening (SbN) and the subsequent iterative progression of fragment hits using structure-assisted chemistry. To maximize impact, we have applied this approach strategically to early- and high-priority targets, and those struggling for leads. Its application has yielded a clinical candidate for BACE1 and lead series in about one third of the SbN/FBDD projects. In this chapter, we will give an overview of our strategy and focus our discussion on NMR-based FBDD approaches. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Visualisation of flow patterns in straight and C-shape thermosyphons

    Science.gov (United States)

    Ong, K. S.; Tshai, K. H.; Firwana, A.

    2017-04-01

    A heat pipe is a passive heat transfer device capable of transferring a large quantity of heat effectively and efficiently over a long distance and with a small temperature difference between the heat source and heat sink. A heat pipe consists of a metal pipe initially vacuumed and then filled with a small quantity of fluid inside. The pipe is separated into a heating (evaporator) section and a cooling (condenser) section by an adiabatic section. In a run-around-coil heating, ventilation and air conditioning system, a wrap-around heat pipe heat exchanger could be employed to increase dehumidification and to reduce cooling costs. The thermal performance of a thermosyphon is dependent upon type of fill liquid, fill ratio, power input, pipe inclination and pipe dimensions. The boiling and condensation processes that occur inside a thermosyphon are quite complex. During operation, dry-out, burn-out or boiling limit, entrainment or flooding limit and geysering occur. These phenomena would lead to non-uniform axial wall temperature distribution in the pipe, or worse still, ineffective operation. In order to have a better understanding of the internal heat transfer phenomena, a visual study using transparent glass tubes and high speed camera recording of the internal flow patterns would be most helpful. This paper reports on an experimental investigation conducted to visualise the flow patterns in straight and C-shape thermosyphons. The pictures recorded enabled the internal flow boiling and condensation pattern occurring inside a straight and a C-shape thermosyphon to be observed. The thermosyphons were fabricated from 10 mm O/D × 8 mm I/D × 300 mm long glass tubes and filled with water with fill ratios from 0.5 - 1.5. The evaporator sections of the thermosyphons were immersed into a hot water tank that was electrically heated from cold at ambient temperature till boiling. Cooling of the condenser section was achieved using a fan. Preliminary results showed that dry

  1. Straight-bladed Darrieus wind turbines - A protagonist's view

    Science.gov (United States)

    Migliore, P. G.

    The technology development and market penetration of Darrieus and propeller-type wind turbines is addressed. Important characteristics of competing configurations are compared, and it is claimed that aerodynamic efficiency is not a distinguishing feature. Advantages of the Darrieus machine include omni-directionality and self-limitation, but propeller types require less rotor length per unit swept area. It is argued that the straight-bladed Darrieus is much simpler than the curved-bladed and should be capable of comparable aerodynamic efficiency. Some of the problems of structural design, as well as blade induced drag losses and support-arm counter torque, diminish rapidly as machine size is increased. Taper ratio has similar beneficial effects.

  2. Plastic anisotropy of straight and cross rolled molybdenum sheets

    International Nuclear Information System (INIS)

    Oertel, C.-G.; Huensche, I.; Skrotzki, W.; Knabl, W.; Lorich, A.; Resch, J.

    2008-01-01

    The microstructure, texture and mechanical properties of molybdenum sheets produced by different rolling processes were investigated by orientation imaging in the scanning electron microscope, X-ray diffraction and tensile tests, respectively. For comparable recrystallization degree of the sheets investigated, straight rolling with low reduction ratio produces α-fiber textures with a maximum at {100} . At higher rolling degrees the maximum shifts to {112} . Cross rolling increases the rotated cube component {100} . The strong differences in the texture measured are reflected in the plastic anisotropy characterized by differences in the yield stress and Lankford parameter which were measured along directions in the rolling plane at angles of 0 deg., 45 deg. and 90 deg. with the rolling direction. The Taylor-Bishop-Hill theory is used successfully to qualitatively explain the plastic anisotropy

  3. Reconstruction of hit time and hit position of annihilation quanta in the J-PET detector using the Mahalanobis distance

    Directory of Open Access Journals (Sweden)

    Sharma Neha Gupta

    2015-12-01

    Full Text Available The J-PET detector being developed at the Jagiellonian University is a positron emission tomograph composed of the long strips of polymer scintillators. At the same time, it is a detector system that will be used for studies of the decays of positronium atoms. The shape of photomultiplier signals depends on the hit time and hit position of the gamma quantum. In order to take advantage of this fact, a dedicated sampling front-end electronics that enables to sample signals in voltage domain with the time precision of about 20 ps and novel reconstruction method based on the comparison of examined signal with the model signals stored in the library has been developed. As a measure of the similarity, we use the Mahalanobis distance. The achievable position and time resolution depend on the number and values of the threshold levels at which the signal is sampled. A reconstruction method as well as preliminary results are presented and discussed.

  4. Thoracolumbar movement in sound horses trotting in straight lines in hand and on the lunge and the relationship with hind limb symmetry or asymmetry.

    Science.gov (United States)

    Greve, L; Pfau, T; Dyson, S

    2017-02-01

    Equine movement symmetry is changed when turning, which may induce alterations in thoracolumbosacral kinematics; however, this has not previously been investigated. Our objectives were to document thoracolumbar movement in subjectively sound horses comparing straight lines with circles on both reins and to relate these observations to the objectively determined symmetry/asymmetry of hindlimb gait. Fourteen non-lame horses were assessed prospectively in a non-random, cross-sectional survey. The horses were trotted in straight lines and lunged on both reins and inertial sensor data collected at landmarks: withers, T13 and T18, L3, tubera sacrale, and left and right tubera coxae. Data were processed using published methods; angular motion range of motion (ROM; flexion-extension, axial rotation, lateral bending) and translational ROM (dorsoventral and lateral) and symmetry within each stride were assessed. The dorsoventral movement of the back exhibited a sinusoidal pattern with two oscillations per stride. Circles induced greater asymmetry in dorsoventral movement within each stride (mean ± standard deviation, up to 9 ± 6%) compared with straight lines (up to 6 ± 6%). The greatest amplitude of dorsoventral movement (119 ± 14 mm in straight lines vs. 126 ± 20 mm in circles) occurred at T13. Circles induced greater flexion-extension ROM (>1.3°; P = 0.002), lateral bending (>16°; P 16 mm; P = 0.002) compared with straight lines. Circles induced a movement pattern similar to an inside hindlimb lameness, which was significantly associated with the circle-induced greater asymmetry of dorsoventral movement of the thoracolumbar region (P = 0.03). Moving in a circle induces measurable changes in thoracolumbar movement compared with moving in straight lines, associated with alterations in the hindlimb gait. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Long-range forces affecting equilibrium inertial focusing behavior in straight high aspect ratio microfluidic channels

    Energy Technology Data Exchange (ETDEWEB)

    Reece, Amy E.; Oakey, John, E-mail: joakey@uwyo.edu [Department of Chemical Engineering, University of Wyoming, Laramie, Wyoming 82071 (United States)

    2016-04-15

    The controlled and directed focusing of particles within flowing fluids is a problem of fundamental and technological significance. Microfluidic inertial focusing provides passive and precise lateral and longitudinal alignment of small particles without the need for external actuation or sheath fluid. The benefits of inertial focusing have quickly enabled the development of miniaturized flow cytometers, size-selective sorting devices, and other high-throughput particle screening tools. Straight channel inertial focusing device design requires knowledge of fluid properties and particle-channel size ratio. Equilibrium behavior of inertially focused particles has been extensively characterized and the constitutive phenomena described by scaling relationships for straight channels of square and rectangular cross section. In concentrated particle suspensions, however, long-range hydrodynamic repulsions give rise to complex particle ordering that, while interesting and potentially useful, can also dramatically diminish the technique’s effectiveness for high-throughput particle handling applications. We have empirically investigated particle focusing behavior within channels of increasing aspect ratio and have identified three scaling regimes that produce varying degrees of geometrical ordering between focused particles. To explore the limits of inertial particle focusing and identify the origins of these long-range interparticle forces, we have explored equilibrium focusing behavior as a function of channel geometry and particle concentration. Experimental results for highly concentrated particle solutions identify equilibrium thresholds for focusing that scale weakly with concentration and strongly with channel geometry. Balancing geometry mediated inertial forces with estimates for interparticle repulsive forces now provide a complete picture of pattern formation among concentrated inertially focused particles and enhance our understanding of the fundamental limits

  6. HIT and brain reward function: A case of mistaken identity (theory).

    Science.gov (United States)

    Wright, Cory; Colombo, Matteo; Beard, Alexander

    2017-08-01

    This paper employs a case study from the history of neuroscience-brain reward function-to scrutinize the inductive argument for the so-called 'Heuristic Identity Theory' (HIT). The case fails to support HIT, illustrating why other case studies previously thought to provide empirical support for HIT also fold under scrutiny. After distinguishing two different ways of understanding the types of identity claims presupposed by HIT and considering other conceptual problems, we conclude that HIT is not an alternative to the traditional identity theory so much as a relabeling of previously discussed strategies for mechanistic discovery. Copyright © 2017. Published by Elsevier Ltd.

  7. Novel HIT antibody detection method using Sonoclot® coagulation analyzer.

    Science.gov (United States)

    Wanaka, Keiko; Asada, Reiko; Miyashita, Kumiko; Kaneko, Makoto; Endo, Hirokazu; Yatomi, Yutaka

    2015-01-01

    Since heparin-induced thrombocytopenia (HIT), caused by the generation of antibodies against platelet factor 4 (PF4)/heparin complexes (HIT antibodies), may induce serious complications due to thrombosis, a prompt diagnosis is desirable. Functional tests with platelet activation to detect HIT antibodies are useful for diagnosis of HIT, in particular (14)C-selotonin release assay (SRA). However, they are complicated and so can be performed only in limited laboratories. We tested if a blood coagulation test using Sonoclot® analyzer can serve for the detection of HIT antibodies. A murine monoclonal antibody (HIT-MoAb) against PF4/heparin complexes was used as an alternative to human HIT antibodies. To the mixture of HIT-MoAb and heparin (0.5 U/mL, final), whole blood obtained from a healthy volunteer was added, and then the activated clotting time (ACT), clot rate (CR), and area under the curve (AUC) were measured with Sonoclot® analyzer for 30minutes. The HIT-MoAb (30 to 100μg/mL, final) concentration dependently suppressed the anticoagulation activity (prolongation of ACT and decrease of CR and AUC) of heparin. The suppression of anticoagulation effect of heparin by HIT-MoAb was demonstrated by measurements using Sonoclot® analyzer. This method may provide a new tool for screening of HIT antibodies. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Is There an Association Between Heparin-Induced Thrombocytopenia (HIT) and Autoimmune Disease?

    Science.gov (United States)

    Klinkhammer, Brent; Gruchalla, Michael

    2018-03-01

    Heparin-induced thrombocytopenia (HIT) is a drug-induced, immunoglobulin G medicated autoimmune disorder associated with several negative clinical outcomes including increased morbidity, mortality, and increased medical costs. Previous studies have shown associations between comorbid autoimmune diseases, but there is little known about associations between HIT and autoimmunity. To provide clinical data to suggest an association between HIT and autoimmunity. Retrospective chart review of 59 cases with a diagnosis of HIT and 251 matched controls without a HIT diagnosis, comparing the prevalence of autoimmunity in each group. A single, large upper Midwest health care system. Patients with a diagnosis of HIT were significantly more likely to have a comorbid autoimmune disease than those without a HIT diagnosis (55.9% vs 10.8%, P HIT were significantly more likely to have a diagnosis of antiphospholipid syndrome (15.3% vs 0.0%, P HIT were significantly older than controls ( P HIT and autoimmune disease and suggests a need for more research into the relationship between HIT and autoimmunity. These results could alter the anticoagulation management of venous thromboembolism and acute coronary syndrome in patients with a previously identified autoimmune disease. Copyright© Wisconsin Medical Society.

  9. Flow characteristics of developing laminar steady flows in a straight duct connected to a square curved duct

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Hyun Chull [Chosun Univ., Gwangju (Korea, Republic of)

    2005-05-01

    In the present study, the characteristics of developing steady laminar flows of a straight duct connected to a 180 .deg. curved duct were examined in the entrance region through experimental measurement. Flow characteristics such as shear stress distributions, pressure distributions and friction coefficient experimentally in a square cross-sectional straight duct by using the PIV system. For the PIV measurement by particles produced from mosquito coils particles. The experimental data were obtained at 9 points dividing the test sections by 400 mm. Experimental results can be summarized as follows. Critical Reynolds number, Re{sub cr} which indicates transition from laminar steady flow to transition steady flow was 2,150. Shear stress per unit length on the wall was stronger than that in the fully developed flow region. This was attributed to the fact that shear stress and pressure loss in the curvature of a duct were increased. Pressure distributions were gradually decreased irrespective of Reynolds number in the whole test section. This trends were in a good agreement with the reference results. Pipe friction coefficient in the steady state flow region was calculate from method of least squares. The co-relationship between fiction coefficient and Reynolds number was established as follow; {lambda}=56/Re.

  10. Multitrajectory eikonal cross sections

    International Nuclear Information System (INIS)

    Turner, R.E.

    1983-01-01

    With the use of reference and distorted transition operators, a time-correlation-function representation of the inelastic differential cross section has recently been used to obtain distorted eikonal cross sections. These cross sections involve straight-line and reference classical translational trajectories that are unaffected by any internal-state changes which have occurred during the collision. This distorted eikonal theory is now extended to include effects of internal-state changes on the translational motion. In particular, a different classical trajectory is associated with each pair of internal states. Expressions for these inelastic cross sections are obtained in terms of time-ordered cosine and sine memory functions using the Zwanzig-Feshbach projection-operator method. Explicit formulas are obtained in the time-disordered perturbation approximation

  11. Gay-Straight Alliance (GSA) Members' Engagement with Sex Education in Canadian High Schools

    Science.gov (United States)

    Lapointe, Alicia

    2014-01-01

    This paper offers an examination of gay-straight alliance (GSA) members' engagement with sex education, sexual health, and prejudice and discrimination in Canadian public high schools. It explores how five students' (four straight and one gay-identifying) participation in GSAs served as a springboard for learning about and challenging stereotypes;…

  12. Standing down Straight: Jump Rhythm Technique's Rhythm-Driven, Community-Directed Approach to Dance Education

    Science.gov (United States)

    Siegenfeld, Billy

    2009-01-01

    "Standing down straight" means to stand on two feet with both stability and relaxation. Using standing down straight as the foundation of class work, Jump Rhythm Technique offers a fresh alternative to conventional systems of dance study. It bases its pedagogy on three behaviors: grounding the body so that it can move with power and efficiency,…

  13. Spherical Projection Based Straight Line Segment Extraction for Single Station Terrestrial Laser Point Cloud

    Directory of Open Access Journals (Sweden)

    ZHANG Fan

    2015-06-01

    Full Text Available Due to the discrete distribution computing errors and lack of adaptability are ubiquitous in the current straight line extraction for TLS data methods. A 3D straight line segment extraction method is proposed based on spherical projection for single station terrestrial laser point clouds. Firstly, horizontal and vertical angles of each laser point are calculated by means of spherical coordinates, intensity panoramic image according to the two angles is generated. Secondly, edges which include straight line features are detected from intensity panoramic image by using of edge detection algorithm. Thirdly, great circles are detected from edges of panoramic image using spherical Hough transform. According to the axiom that a straight line segment in 3D space is a spherical great circle after spherical projection, detecting great circles from spherical projected data sets is essentially detecting straight line segments from 3D data sets without spherical projection. Finally, a robust 3D straight line fitting method is employed to fitting the straight lines and calculating parameters of the straight line segments. Experiments using different data sets and comparison with other methods show the accuracy and applicability of the proposed method.

  14. A simple algorithm for computing positively weighted straight skeletons of monotone polygons☆

    Science.gov (United States)

    Biedl, Therese; Held, Martin; Huber, Stefan; Kaaser, Dominik; Palfrader, Peter

    2015-01-01

    We study the characteristics of straight skeletons of monotone polygonal chains and use them to devise an algorithm for computing positively weighted straight skeletons of monotone polygons. Our algorithm runs in O(nlog⁡n) time and O(n) space, where n denotes the number of vertices of the polygon. PMID:25648376

  15. A simple algorithm for computing positively weighted straight skeletons of monotone polygons.

    Science.gov (United States)

    Biedl, Therese; Held, Martin; Huber, Stefan; Kaaser, Dominik; Palfrader, Peter

    2015-02-01

    We study the characteristics of straight skeletons of monotone polygonal chains and use them to devise an algorithm for computing positively weighted straight skeletons of monotone polygons. Our algorithm runs in [Formula: see text] time and [Formula: see text] space, where n denotes the number of vertices of the polygon.

  16. Current drive experiments on the HIT-II spherical torus

    International Nuclear Information System (INIS)

    Jarboe, T.R.; Raman, R.; Nelson, B.A.; Holcomb, C.T.; McCollam, K.J.; Sieck, P.E.

    1999-01-01

    This paper describes the following new achievements from the Helicity Injected Torus (HIT) program: a) formation and sustainment of a toroidal magnetic equilibrium using coaxial helicity injection (CHI) in a conducting shell that has an L/R time much shorter than the pulse length; b) static formation of a spherical torus with plasma current over 180 kA using a transformer and feedback controlled equilibrium coils; and c) production of a current increase in a transformer produced spherical torus using CHI. (author)

  17. Current drive experiments on the HIT-II spherical torus

    International Nuclear Information System (INIS)

    Jarboe, T.; Raman, R.; Nelson, B.; Holcomb, C.T.; McCollam, K.J.; Sieck, P.E.

    2001-01-01

    This paper describes the following new achievements from the Helicity Injected Torus (HIT) program: a) formation and sustainment of a toroidal magnetic equilibrium using coaxial helicity injection (CHI) in a conducting shell that has an L/R time much shorter than the pulse length; b) static formation of a spherical torus with plasma current over 180 kA using a transformer and feedback controlled equilibrium coils; and c) production of a current increase in a transformer produced spherical torus using CHI. (author)

  18. Current drive experiments in the HIT-II spherical tokamak

    International Nuclear Information System (INIS)

    Jarboe, T.R.; Gu, P.; Isso, V.A.; Jewell, P.E.; McCollam, K.J.; Nelson, B.A.; Ramon, R.; Redd, A.J.; Sieck, P.E.; Smith, R.J.; Nagata, M.; Uyama, T.

    2001-01-01

    The Helicity Injected Torus (Hit) program has made progress in understanding relaxation and helicity injection current drive. Helicity-conserving MHD activity during the inductive (Ohmic) current ramp demonstrates the profile flattening needed for coaxial helicity injection (CHI). Results from cathode and anode central column (CC) CHI pulses are consistent with the electron locking model of current drive from a pure n=1 mode. Finally, low density CHI, compatible with Ohmic operation, has been achieved. Some enhancement of CHI discharges with the application of Ohmic is shown. (author)

  19. The Holistic Integrity Test (HIT - quantified resilience analysis

    Directory of Open Access Journals (Sweden)

    Dobson Mike

    2016-01-01

    Full Text Available The Holistic Integrity Test (HIT - Quantified Resilience Analysis. Rising sea levels and wider climate change mean we face an increasing risk from flooding and other natural hazards. Tough economic times make it difficult to economically justify or afford the desired level of engineered risk reduction. Add to this significant uncertainty from a range of future predictions, constantly updated with new science. We therefore need to understand not just how to reduce the risk, but what could happen should above design standard events occur. In flood terms this includes not only the direct impacts (damage and loss of life, but the wider cascade impacts to infrastructure systems and the longer term impacts on the economy and society. However, understanding the “what if” is only the first part of the equation; a range of improvement measures to mitigate such effects need to be identified and implemented. These measures should consider reducing the risk, lessening the consequences, aiding the response, and speeding up the recovery. However, they need to be objectively assessed through quantitative analysis, which underpins them technically and economically. Without such analysis, it cannot be predicted how measures will perform if the extreme events occur. It is also vital to consider all possible hazards as measures for one hazard may hinder the response to another. The Holistic Integrity Test (HIT, uses quantitative system analysis and “HITs” the site, its infrastructure, contained dangers and wider regional system to determine how it copes with a range of severe shock events, Before, During and After the event, whilst also accounting for uncertainty (as illustrated in figure 1. First explained at the TINCE 2014 Nuclear Conference in Paris, it was explained in terms of a Nuclear Facility needing to analyse the site in response to post Fukushima needs; the hit is however universally applicable. The HIT has three key risk reduction goals: The

  20. Liquid Argon TPC Signal Formation, Signal Processing and Hit Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Baller, Bruce [Fermilab

    2017-03-11

    This document describes the early stage of the reconstruction chain that was developed for the ArgoNeuT and MicroBooNE experiments at Fermilab. These experiments study accelerator neutrino interactions that occur in a Liquid Argon Time Projection Chamber. Reconstructing the properties of particles produced in these interactions requires knowledge of the micro-physics processes that affect the creation and transport of ionization electrons to the readout system. A wire signal deconvolution technique was developed to convert wire signals to a standard form for hit reconstruction, to remove artifacts in the electronics chain and to remove coherent noise.

  1. ANALYSIS MUSIC CONCERTS ADOPTING THE MATHEMATICAL MODEL OF HIT PHENOMENA

    OpenAIRE

    Kawahata Yasuko; Genda Etsuo; Ishii Akira

    2013-01-01

    A mathematical model for the hit phenomenon in entertainment within a society is presented as a stochastic process of interactions of human dynamics. In this paper, we analyzed music to the concert.Knowing the cost of advertising the concert is difficult. But exposure to the media of the artist can be seen. We tried to analysis of music concert itself by performing a prediction of reputation of artists during the concert tour from this exposure.In this paper, The world most pop...

  2. A laser interferometer for measuring straightness and its position based on heterodyne interferometry

    International Nuclear Information System (INIS)

    Chen Benyong; Zhang Enzheng; Yan Liping; Li Chaorong; Tang Wuhua; Feng Qibo

    2009-01-01

    Not only the magnitude but also the position of straightness errors are of concern to users. However, current laser interferometers used for measuring straightness seldom give the relative position of the straightness error. To solve this problem, a laser interferometer for measuring straightness and its position based on heterodyne interferometry is proposed. The optical configuration of the interferometer is designed and the measurement principle is analyzed theoretically. Two experiments were carried out. The first experiment verifies the validity and repeatability of the interferometer by measuring a linear stage. Also, the second one for measuring a flexure-hinge stage demonstrates that the interferometer is capable of nanometer measurement accuracy. These results show that this interferometer has advantages of simultaneously measuring straightness error and the relative position with high precision, and a compact structure.

  3. Defect Depth Measurement of Straight Pipe Specimen Using Shearography

    International Nuclear Information System (INIS)

    Chang, Ho Seob; Kim, Kyung Suk

    2012-01-01

    In the nuclear industry, wall thinning defect of straight pipe occur the enormous loss in life evaluation and safety evaluation. To use non-destructive technique, we measure deformation, vibration, defect evaluation. But, this techniques are a weak that is the measurement of the wide area is difficult and the time is caught long. In the secondary side of nuclear power plants mostly used steel pipe, artificiality wall thinning defect make in the side and different thickness make to the each other, wall thinning defect part of deformation measure by using shearography. In addition, optical measurement through deformation, vibration, defect evaluation evaluate pipe and thickness defects of pressure vessel is to evaluate quantitatively. By shearography interferometry to measure the pipe's internal wall thinning defect and the variation of pressure use the proposed technique, the quantitative defect is to evaluate the thickness of the surplus. The amount of deformation use thickness of surplus prediction of the actual thickness defect and approximately 7 percent error by ensure reliability. According to pressure the amount of deformation and the thickness of the surplus through DB construction, nuclear power plant pipe use wall thinning part soundness evaluation. In this study, pressure vessel of thickness defect measure proposed nuclear pipe of wall thinning defect prediction and integrity assessment technology development. As a basic research defected theory and experiment, pressure vessel of advanced stability and soundness and maintainability is expected to contribute foundation establishment

  4. Youth Empowerment and High School Gay-Straight Alliances

    Science.gov (United States)

    Muraco, Anna; Subramaniam, Aarti; Laub, Carolyn

    2010-01-01

    In the field of positive youth development programs, “empowerment” is used interchangeably with youth activism, leadership, civic participation and self-efficacy. However, few studies have captured what empowerment means to young people in diverse contexts. This article explores how youth define and experience empowerment in youth-led organizations characterized by social justice goals: high school Gay-Straight Alliances (GSAs). Through focus group interviews, fifteen youth leaders of GSAs from different regions of California explain what they think empowerment means and how they became empowered through their involvement with the GSA. Youth describe three inter-related dimensions of empowerment: personal empowerment, relational empowerment, and strategic empowerment through having and using knowledge. When these three dimensions are experienced in combination, GSA leaders have the potential for individual and collective empowerment as agents of social change at school. By understanding these youth's perspectives on the meanings of empowerment, this article clarifies the conceptual arena for future studies of socially marginalized youth and of positive youth development. PMID:19636734

  5. Straight cylindrical seal for high-performance turbomachines

    Science.gov (United States)

    Hendricks, Robert C.

    1987-01-01

    A straight cylindrical seal configuration representing the seal for a high-performance turbopump (e.g., the space shuttle main engine fuel pump) was tested under static (nonrotating) conditions. The test data included critical mass flux and pressure profiles over a wide range of inlet temperatures and pressures for fluid nitrogen and fluid hydrogen with the seal in concentric and fully eccentric positions. The critical mass fluxes (or leakage rates) for the concentric and fully eccentric configurations were nearly the same when based on stagnation conditions upstream of the seal. The fully eccentric configuration pressure profiles of the gas and liquid were different. Further, the pressure differences between the maximum and the minimum clearance positions were highly dependent on the geometric conditions, the temperature, and the absolute pressure at both the inlet and the exit. The pressure differences were greatest in the inlet region. The results, although complex, tend to follow the corresponding-states principles for critical flows. Gaseous injection near the seal exit plane significantly altered the pressure profiles and could be used to control turbomachine instabilities.

  6. Receptivity of Hypersonic Boundary Layers over Straight and Flared Cones

    Science.gov (United States)

    Balakumar, Ponnampalam; Kegerise, Michael A.

    2010-01-01

    The effects of adverse pressure gradients on the receptivity and stability of hypersonic boundary layers were numerically investigated. Simulations were performed for boundary layer flows over a straight cone and two flared cones. The steady and the unsteady flow fields were obtained by solving the two-dimensional Navier-Stokes equations in axi-symmetric coordinates using the 5th order accurate weighted essentially non-oscillatory (WENO) scheme for space discretization and using third-order total-variation-diminishing (TVD) Runge-Kutta scheme for time integration. The mean boundary layer profiles were analyzed using local stability and non-local parabolized stability equations (PSE) methods. After the most amplified disturbances were identified, two-dimensional plane acoustic waves were introduced at the outer boundary of the computational domain and time accurate simulations were performed. The adverse pressure gradient was found to affect the boundary layer stability in two important ways. Firstly, the frequency of the most amplified second-mode disturbance was increased relative to the zero pressure gradient case. Secondly, the amplification of first- and second-mode disturbances was increased. Although an adverse pressure gradient enhances instability wave growth rates, small nose-tip bluntness was found to delay transition due to the low receptivity coefficient and the resulting weak initial amplitude of the instability waves. The computed and measured amplitude-frequency spectrums in all three cases agree very well in terms of frequency and the shape except for the amplitude.

  7. Youth empowerment and high school Gay-Straight Alliances.

    Science.gov (United States)

    Russell, Stephen T; Muraco, Anna; Subramaniam, Aarti; Laub, Carolyn

    2009-08-01

    In the field of positive youth development programs, "empowerment" is used interchangeably with youth activism, leadership, civic participation and self-efficacy. However, few studies have captured what empowerment means to young people in diverse contexts. This article explores how youth define and experience empowerment in youth-led organizations characterized by social justice goals: high school Gay-Straight Alliances (GSAs). Through focus group interviews, fifteen youth leaders of GSAs from different regions of California explain what they think empowerment means and how they became empowered through their involvement with the GSA. Youth describe three inter-related dimensions of empowerment: personal empowerment, relational empowerment, and strategic empowerment through having and using knowledge. When these three dimensions are experienced in combination, GSA leaders have the potential for individual and collective empowerment as agents of social change at school. By understanding these youth's perspectives on the meanings of empowerment, this article clarifies the conceptual arena for future studies of socially marginalized youth and of positive youth development.

  8. Estimate of aircraft crash hit frequencies on to facilities at the Lawrence Livermore National Laboratory (LLNL) Site 200

    International Nuclear Information System (INIS)

    Kimura, C.Y.

    1997-01-01

    Department of Energy (DOE) nuclear facilities are required by DOE Order 5480.23, Section 8.b.(3)(k) to consider external events as initiating events to accidents within the scope of their Safety Analysis Reports (SAR). One of the external initiating events which should be considered within the scope of a SAR is an aircraft accident, i.e., an aircraft crashing into the nuclear facility with the related impact and fire leading to penetration of the facility and to the release of radioactive and/or hazardous materials. This report presents the results of an Aircraft Crash Frequency analysis performed for the Materials Management Area (MMA), and the National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) Site 200. The analysis estimates only the aircraft crash hit frequency on to the analyzed facilities. No initial aircraft crash hit frequency screening structural response calculations of the facilities to the aircraft impact, or consequence analysis of radioactive/hazardous materials released following the aircraft impact are performed. The method used to estimate the aircraft crash hit frequencies on to facilities at the Lawrence Livermore National Laboratory (LLNL) generally follows the procedure given by the DOE Standard 3014-96 on Aircraft Crash Analysis. However, certain adjustments were made to the DOE Standard procedure because of the site specific fight environment or because of facility specific characteristics

  9. Capture orbits around asteroids by hitting zero-velocity curves

    Science.gov (United States)

    Wang, Wei; Yang, Hongwei; Zhang, Wei; Ma, Guangfu

    2017-12-01

    The problem of capturing a spacecraft from a heliocentric orbit into a high parking orbit around binary asteroids is investigated in the current study. To reduce the braking Δ V, a new capture strategy takes advantage of the three-body gravity of the binary asteroid to lower the inertial energy before applying the Δ V. The framework of the circular restricted three-body problem (CR3BP) is employed for the binary asteroid system. The proposed capture strategy is based on the mechanism by which inertial energy can be decreased sharply near zero-velocity curves (ZVCs). The strategy has two steps, namely, hitting the target ZVC and raising the periapsis by a small Δ V at the apoapsis. By hitting the target ZVC, the positive inertial energy decreases and becomes negative. Using a small Δ V, the spacecraft inserts into a bounded orbit around the asteroid. In addition, a rotating mass dipole model is employed for elongated asteroids, which leads to dynamics similar to that of the CR3BP. With this approach, the proposed capture strategy can be applied to elongated asteroids. Numerical simulations validate that the proposed capture strategy is applicable for the binary asteroid 90 Antiope and the elongated asteroid 216 Kleopatra.

  10. Adiabatic condition and the quantum hitting time of Markov chains

    International Nuclear Information System (INIS)

    Krovi, Hari; Ozols, Maris; Roland, Jeremie

    2010-01-01

    We present an adiabatic quantum algorithm for the abstract problem of searching marked vertices in a graph, or spatial search. Given a random walk (or Markov chain) P on a graph with a set of unknown marked vertices, one can define a related absorbing walk P ' where outgoing transitions from marked vertices are replaced by self-loops. We build a Hamiltonian H(s) from the interpolated Markov chain P(s)=(1-s)P+sP ' and use it in an adiabatic quantum algorithm to drive an initial superposition over all vertices to a superposition over marked vertices. The adiabatic condition implies that, for any reversible Markov chain and any set of marked vertices, the running time of the adiabatic algorithm is given by the square root of the classical hitting time. This algorithm therefore demonstrates a novel connection between the adiabatic condition and the classical notion of hitting time of a random walk. It also significantly extends the scope of previous quantum algorithms for this problem, which could only obtain a full quadratic speedup for state-transitive reversible Markov chains with a unique marked vertex.

  11. Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

    Science.gov (United States)

    Devine, Shane M; Mulcair, Mark D; Debono, Cael O; Leung, Eleanor W W; Nissink, J Willem M; Lim, San Sui; Chandrashekaran, Indu R; Vazirani, Mansha; Mohanty, Biswaranjan; Simpson, Jamie S; Baell, Jonathan B; Scammells, Peter J; Norton, Raymond S; Scanlon, Martin J

    2015-02-12

    We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified by 4-phenylthiazol-2-amine being identified as a hit in 14/14 screens against a diverse range of protein targets, suggesting that this scaffold is a poor starting point for fragment-based drug discovery. This prompted us to analyze this scaffold in the context of an academic fragment library used for fragment-based drug discovery (FBDD) and two larger compound libraries used for high-throughput screening (HTS). This analysis revealed that such "promiscuous 2-aminothiazoles" (PrATs) behaved as frequent hitters under both FBDD and HTS settings, although the problem was more pronounced in the fragment-based studies. As 2-ATs are present in known drugs, they cannot necessarily be deemed undesirable, but the combination of their promiscuity and difficulties associated with optimizing them into a lead compound makes them, in our opinion, poor scaffolds for fragment libraries.

  12. NuFact muon storage ring: study of a triangle design based on solenoid focusing decay straights

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Service Accelerateurs, Laboratoire de Physique Subatomique et de Cosmologie, Universite Joseph Fourier / CNRS-IN2P3, 53 Avenue des Martyrs, F-38026 Grenoble (France)]|[Commissariat a l' Energie Atomique, CEA, 31-33, rue de la Federation (Paris 15e), BP 510, 75752 Paris Cedex 15 (France); Reesy, G. [Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot OX11 0QX (United Kingdom)

    2006-06-15

    Properties of acceptance and beam transmission in a triangle design of the neutrino factory muon decay ring, with decay straights based on solenoidal focusing, are reported.The muon storage ring in the neutrino factory, NuFact, is located at the high energy end of the muon acceleration chain. It delivers the {mu}{sup +}/{mu}{sup -} decay neutrinos to physics detectors. The design of concern here, is a triangle geometry 20 GeV storage ring, upgradable to 50 GeV, (the parameters are given), which features two decay straight sections, each one aiming at a distant detector. The third straight section of the ring is devoted to tuning, collimation and RF. A particularity of the proposed design, is in its being based on solenoid focusing decay straights, which has the virtue of minimizing the betatron amplitudes, compared to equivalent quadrupole focusing. The solenoidal focusing ensures the requested ratio, for the r.m.s. divergences of the 20 GeV muon and the neutrino beam, of 0.1 for an assumed muon normalized r.m.s. emittance of 4800 {pi} mm mr (3 {pi} cm, total). The goal of the present work is to show the viability of this design, in particular as concerns the impact of the solenoid focusing on machine behavior. It addresses the questions of residual coupling, machine acceptance, and concludes with a computation of beam transmission over 1000 turns. The paper has the following structure: 1. Introduction; 2. Working hypothesis; 3. Building-up ray-tracing data; 3.1. Arcs; 3.2. Solenoid straight; 3.3. Tuning/Collimation/RF straight; 3.4. Full ring; 3.4.1. Beam envelopes; 3.4.2. Closed orbits; 3.4.3. Momentum dispersion; 3.5 Large amplitude tracking, preliminary tests; 4. Tracking, linear machine; 4.1. Large amplitude tracking; 4.1.1. 2-D horizontal initial conditions; 4.1.2. 2-D vertical initial conditions; 4.1.3. 4-D + {delta}p/p initial conditions; 4.2. Transmission, 4-D + {delta}p/p, no sextupoles; 4.2.1. {epsilon}{sub x} {epsilon}{sub z} = 3 {pi} cm (norm.), {delta

  13. NuFact muon storage ring: study of a triangle design based on solenoid focusing decay straights

    International Nuclear Information System (INIS)

    Meot, F.; Reesy, G.

    2006-06-01

    Properties of acceptance and beam transmission in a triangle design of the neutrino factory muon decay ring, with decay straights based on solenoidal focusing, are reported.The muon storage ring in the neutrino factory, NuFact, is located at the high energy end of the muon acceleration chain. It delivers the μ + /μ - decay neutrinos to physics detectors. The design of concern here, is a triangle geometry 20 GeV storage ring, upgradable to 50 GeV, (the parameters are given), which features two decay straight sections, each one aiming at a distant detector. The third straight section of the ring is devoted to tuning, collimation and RF. A particularity of the proposed design, is in its being based on solenoid focusing decay straights, which has the virtue of minimizing the betatron amplitudes, compared to equivalent quadrupole focusing. The solenoidal focusing ensures the requested ratio, for the r.m.s. divergences of the 20 GeV muon and the neutrino beam, of 0.1 for an assumed muon normalized r.m.s. emittance of 4800 π mm mr (3 π cm, total). The goal of the present work is to show the viability of this design, in particular as concerns the impact of the solenoid focusing on machine behavior. It addresses the questions of residual coupling, machine acceptance, and concludes with a computation of beam transmission over 1000 turns. The paper has the following structure: 1. Introduction; 2. Working hypothesis; 3. Building-up ray-tracing data; 3.1. Arcs; 3.2. Solenoid straight; 3.3. Tuning/Collimation/RF straight; 3.4. Full ring; 3.4.1. Beam envelopes; 3.4.2. Closed orbits; 3.4.3. Momentum dispersion; 3.5 Large amplitude tracking, preliminary tests; 4. Tracking, linear machine; 4.1. Large amplitude tracking; 4.1.1. 2-D horizontal initial conditions; 4.1.2. 2-D vertical initial conditions; 4.1.3. 4-D + δp/p initial conditions; 4.2. Transmission, 4-D + δp/p, no sextupoles; 4.2.1. ε x ε z = 3 π cm (norm.), δp/p = ±1%; 4.2.2. ε x ε z = 6 π cm (norm.), δp/p ±4

  14. SHIELD-HIT12A - a Monte Carlo particle transport program for ion therapy research

    DEFF Research Database (Denmark)

    Bassler, Niels; Hansen, David Christoffer; Lühr, Armin

    2014-01-01

    . We experienced that new users quickly learn to use SHIELD-HIT12A and setup new geometries. Contrary to previous versions of SHIELD-HIT, the 12A distribution comes along with easy-to-use example files and an English manual. A new implementation of Vavilov straggling resulted in a massive reduction......Abstract. Purpose: The Monte Carlo (MC) code SHIELD-HIT simulates the transport of ions through matter. Since SHIELD-HIT08 we added numerous features that improves speed, usability and underlying physics and thereby the user experience. The “-A” fork of SHIELD-HIT also aims to attach SHIELD....... It supports native formats compatible with the heavy ion treatment planning system TRiP. Stopping power files follow ICRU standard and are generated using the libdEdx library, which allows the user to choose from a multitude of stopping power tables. Results: SHIELD-HIT12A runs on Linux and Windows platforms...

  15. Straight velocity boundaries in the lattice Boltzmann method

    Science.gov (United States)

    Latt, Jonas; Chopard, Bastien; Malaspinas, Orestis; Deville, Michel; Michler, Andreas

    2008-05-01

    Various ways of implementing boundary conditions for the numerical solution of the Navier-Stokes equations by a lattice Boltzmann method are discussed. Five commonly adopted approaches are reviewed, analyzed, and compared, including local and nonlocal methods. The discussion is restricted to velocity Dirichlet boundary conditions, and to straight on-lattice boundaries which are aligned with the horizontal and vertical lattice directions. The boundary conditions are first inspected analytically by applying systematically the results of a multiscale analysis to boundary nodes. This procedure makes it possible to compare boundary conditions on an equal footing, although they were originally derived from very different principles. It is concluded that all five boundary conditions exhibit second-order accuracy, consistent with the accuracy of the lattice Boltzmann method. The five methods are then compared numerically for accuracy and stability through benchmarks of two-dimensional and three-dimensional flows. None of the methods is found to be throughout superior to the others. Instead, the choice of a best boundary condition depends on the flow geometry, and on the desired trade-off between accuracy and stability. From the findings of the benchmarks, the boundary conditions can be classified into two major groups. The first group comprehends boundary conditions that preserve the information streaming from the bulk into boundary nodes and complete the missing information through closure relations. Boundary conditions in this group are found to be exceptionally accurate at low Reynolds number. Boundary conditions of the second group replace all variables on boundary nodes by new values. They exhibit generally much better numerical stability and are therefore dedicated for use in high Reynolds number flows.

  16. Plasma response to sustainment with imposed-dynamo current drive in HIT-SI and HIT-SI3

    Science.gov (United States)

    Hossack, A. C.; Jarboe, T. R.; Chandra, R. N.; Morgan, K. D.; Sutherland, D. A.; Penna, J. M.; Everson, C. J.; Nelson, B. A.

    2017-07-01

    The helicity injected torus—steady inductive (HIT-SI) program studies efficient, steady-state current drive for magnetic confinement plasmas using a novel experimental method. Stable, high-beta spheromaks have been sustained using steady, inductive current drive. Externally induced loop voltage and magnetic flux are oscillated together so that helicity and power injection are always positive, sustaining the edge plasma current indefinitely. Imposed-dynamo current drive (IDCD) theory further shows that the entire plasma current is sustained. The method is ideal for low aspect ratio, toroidal geometries with closed flux surfaces. Experimental studies of spheromak plasmas sustained with IDCD have shown stable magnetic profiles with evidence of pressure confinement. New measurements show coherent motion of a stable spheromak in response to the imposed perturbations. On the original device two helicity injectors were mounted on either side of the spheromak and the injected mode spectrum was predominantly n  =  1. Coherent, rigid motion indicates that the spheromak is stable and a lack of plasma-generated n  =  1 energy indicates that the maximum q is maintained below 1 during sustainment. Results from the HIT-SI3 device are also presented. Three inductive helicity injectors are mounted on one side of the spheromak flux conserver. Varying the relative injector phasing changes the injected mode spectrum which includes n  =  2, 3, and higher modes.

  17. Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review.

    Science.gov (United States)

    Warkentin, Theodore E; Pai, Menaka; Linkins, Lori-Ann

    2017-08-31

    Direct oral anticoagulants (DOACs) are attractive options for treatment of heparin-induced thrombocytopenia (HIT). We report our continuing experience in Hamilton, ON, Canada, since January 1, 2015 (when we completed our prospective study of rivaroxaban for HIT), using rivaroxaban for serologically confirmed HIT (4Ts score ≥4 points; positive platelet factor 4 [PF4]/heparin immunoassay, positive serotonin-release assay). We also performed a literature review of HIT treatment using DOACs (rivaroxaban, apixaban, dabigatran, edoxaban). We focused on patients who received DOAC therapy for acute HIT as either primary therapy (group A) or secondary therapy (group B; initial treatment using a non-DOAC/non-heparin anticoagulant with transition to a DOAC during HIT-associated thrombocytopenia). Our primary end point was occurrence of objectively documented thrombosis during DOAC therapy for acute HIT. We found that recovery without new, progressive, or recurrent thrombosis occurred in all 10 Hamilton patients with acute HIT treated with rivaroxaban. Data from the literature review plus these new data identified a thrombosis rate of 1 of 46 patients (2.2%; 95% CI, 0.4%-11.3%) in patients treated with rivaroxaban during acute HIT (group A, n = 25; group B, n = 21); major hemorrhage was seen in 0 of 46 patients. Similar outcomes in smaller numbers of patients were observed with apixaban (n = 12) and dabigatran (n = 11). DOACs offer simplified management of selected patients, as illustrated by a case of persisting (autoimmune) HIT (>2-month platelet recovery with inversely parallel waning of serum-induced heparin-independent serotonin release) with successful outpatient rivaroxaban management of HIT-associated thrombosis. Evidence supporting efficacy and safety of DOACs for acute HIT is increasing, with the most experience reported for rivaroxaban. © 2017 by The American Society of Hematology.

  18. Intubation of prehospital patients with curved laryngoscope blade is more successful than with straight blade.

    Science.gov (United States)

    Alter, Scott M; Haim, Eithan D; Sullivan, Alex H; Clayton, Lisa M

    2018-02-17

    Direct laryngoscopy can be performed using curved or straight blades, and providers usually choose the blade they are most comfortable with. However, curved blades are anecdotally thought of as easier to use than straight blades. We seek to compare intubation success rates of paramedics using curved versus straight blades. Design: retrospective chart review. hospital-based suburban ALS service with 20,000 annual calls. prehospital patients with any direct laryngoscopy intubation attempt over almost 9years. First attempt and overall success rates were calculated for attempts with curved and straight blades. Differences between the groups were calculated. 2299 patients were intubated by direct laryngoscopy. 1865 had attempts with a curved blade, 367 had attempts with a straight blade, and 67 had attempts with both. Baseline characteristics were similar between groups. First attempt success was 86% with a curved blade and 73% with a straight blade: a difference of 13% (95% CI: 9-17). Overall success was 96% with a curved blade and 81% with a straight blade: a difference of 15% (95% CI: 12-18). There was an average of 1.11 intubation attempts per patient with a curved blade and 1.13 attempts per patient with a straight blade (2% difference, 95% CI: -3-7). Our study found a significant difference in intubation success rates between laryngoscope blade types. Curved blades had higher first attempt and overall success rates when compared to straight blades. Paramedics should consider selecting a curved blade as their tool of choice to potentially improve intubation success. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Prenatal cannabis exposure - The "first hit" to the endocannabinoid system.

    Science.gov (United States)

    Richardson, Kimberlei A; Hester, Allison K; McLemore, Gabrielle L

    As more states and countries legalize medical and/or adult recreational marijuana use, the incidences of prenatal cannabis exposure (PCE) will likely increase. While young people increasingly view marijuana as innocuous, marijuana preparations have been growing in potency in recent years, potentially creating global clinical, public health, and workforce concerns. Unlike fetal alcohol spectrum disorder, there is no phenotypic syndrome associated with PCE. There is also no preponderance of evidence that PCE causes lifelong cognitive, behavioral, or functional abnormalities, and/or susceptibility to subsequent addiction. However, there is compelling circumstantial evidence, based on the principles of teratology and fetal malprogramming, suggesting that pregnant women should refrain from smoking marijuana. The usage of marijuana during pregnancy perturbs the fetal endogenous cannabinoid signaling system (ECSS), which is present and active from the early embryonic stage, modulating neurodevelopment and continuing this role into adulthood. The ECSS is present in virtually every brain structure and organ system, and there is also evidence that this system is important in the regulation of cardiovascular processes. Endocannabinoids (eCBs) undergird a broad spectrum of processes, including the early stages of fetal neurodevelopment and uterine implantation. Delta-9-tetrahydrocannabinol (THC), the psychoactive chemical in cannabis, enters maternal circulation, and readily crosses the placental membrane. THC binds to CB receptors of the fetal ECSS, altering neurodevelopment and possibly rewiring ECSS circuitry. In this review, we discuss the Double-Hit Hypothesis as it relates to PCE. We contend that PCE, similar to a neurodevelopmental teratogen, delivers the first hit to the ECSS, which is compromised in such a way that a second hit (i.e., postnatal stressors) will precipitate the emergence of a specific phenotype. In summary, we conclude that perturbations of the

  20. Transmission of fast highly charged ions through straight and tapered glass capillaries

    International Nuclear Information System (INIS)

    Ayyad, Asma M; Keerthisinghe, D; Kayani, A; Tanis, J A; Dassanayake, B S; Ikeda, T

    2013-01-01

    The transmission of 1 and 3 MeV protons through a borosilicate straight glass capillary and a tapered glass capillary was investigated. The straight capillary had a diameter of ∼0.18 mm and a length of ∼14.4 mm, while the tapered capillary had an inlet diameter of ∼0.71 mm, an outlet diameter of ∼0.10 mm and a length of ∼28 mm. The results show that the 1 and 3 MeV protons traverse through both samples without energy loss, while the tapered capillary showed better transmission than the straight capillary. (paper)

  1. [The peculiar morphological features of the imprints of straight and wavy head hair dirtied with blood].

    Science.gov (United States)

    Leonova, E N; Nagornov, M N; Prokhorenko, A S

    2018-01-01

    The objective of the present study was to elucidate the specific morphological features of the imprints of blood-soaked straight and wavy head hair. The contact imprints of straight and wavy head hair dirtied with blood were obtained experimentally. The imprints of straight hair were shown to exhibit the elements in the form of the rectilinear and bow-shaped slightly bent stripes. The imprints of wavy hair were shaped as the arches, waves, circles, and a large number of various small elements, such as dashes and commas.

  2. Validation of the Impact of Health Information Technology (I-HIT) Scale: an international collaborative.

    Science.gov (United States)

    Dykes, Patricia C; Hurley, Ann C; Brown, Suzanne; Carr, Robyn; Cashen, Margaret; Collins, Rita; Cook, Robyn; Currie, Leanne; Docherty, Charles; Ensio, Anneli; Foster, Joanne; Hardiker, Nicholas R; Honey, Michelle L L; Killalea, Rosaleen; Murphy, Judy; Saranto, Kaija; Sensmeier, Joyce; Weaver, Charlotte

    2009-01-01

    In 2005, the Healthcare Information Management Systems Society (HIMSS) Nursing Informatics Community developed a survey to measure the impact of health information technology (HIT), the I-HIT Scale, on the role of nurses and interdisciplinary communication in hospital settings. In 2007, nursing informatics colleagues from Australia, England, Finland, Ireland, New Zealand, Scotland and the United States formed a research collaborative to validate the I-HIT across countries. All teams have completed construct and face validation in their countries. Five out of six teams have initiated reliability testing by practicing nurses. This paper reports the international collaborative's validation of the I-HIT Scale completed to date.

  3. School Climate, Individual Support, or Both? Gay-Straight Alliances and the Mental Health of Sexual Minority Youth

    Science.gov (United States)

    Walls, N. Eugene; Wisneski, Hope; Kane, Sarah

    2013-01-01

    Using a sample of 284 sexual minority youth and young adults, this paper examines the relationships between mental health variables, the absence or presence of a gay-straight alliance, and membership status in a gay-straight alliance. The results suggest that the presence of a gay-straight alliance in a school or college, rather than actual…

  4. Inflammation and the Two-Hit Hypothesis of Schizophrenia

    Science.gov (United States)

    Feigenson, Keith A.; Kusnecov, Alex W.; Silverstein, Steven M.

    2014-01-01

    The high societal and individual cost of schizophrenia necessitates finding better, more effective treatment, diagnosis, and prevention strategies. One of the obstacles in this endeavor is the diverse set of etiologies that comprises schizophrenia. A substantial body of evidence has grown over the last few decades to suggest that schizophrenia is a heterogeneous syndrome with overlapping symptoms and etiologies. At the same time, an increasing number of clinical, epidemiological, and experimental studies have shown links between schizophrenia and inflammatory conditions. In this review, we analyze the literature on inflammation and schizophrenia, with a particular focus on comorbidity, biomarkers, and environmental insults. We then identify several mechanisms by which inflammation could influence the development of schizophrenia via the two-hit hypothesis. Lastly, we note the relevance of these findings to clinical applications in the diagnosis, prevention, and treatment of schizophrenia. PMID:24247023

  5. Tracking, aiming, and hitting the UAV with ordinary assault rifle

    Science.gov (United States)

    Racek, František; Baláž, Teodor; Krejčí, Jaroslav; Procházka, Stanislav; Macko, Martin

    2017-10-01

    The usage small-unmanned aerial vehicles (UAVs) is significantly increasing nowadays. They are being used as a carrier of military spy and reconnaissance devices (taking photos, live video streaming and so on), or as a carrier of potentially dangerous cargo (intended for destruction and killing). Both ways of utilizing the UAV cause the necessity to disable it. From the military point of view, to disable the UAV means to bring it down by a weapon of an ordinary soldier that is the assault rifle. This task can be challenging for the soldier because he needs visually detect and identify the target, track the target visually and aim on the target. The final success of the soldier's mission depends not only on the said visual tasks, but also on the properties of the weapon and ammunition. The paper deals with possible methods of prediction of probability of hitting the UAV targets.

  6. Aeroelastic modeling of composite rotor blades with straight and swept tips

    Science.gov (United States)

    Yuan, Kuo-An; Friedmann, Peretz P.; Venkatesan, Comandur

    1992-01-01

    This paper presents an analytical study of the aeroelastic behavior of composite rotor blades with straight and swept tips. The blade is modeled by beam type finite elements. A single finite element is used to model the swept tip. The nonlinear equations of motion for the FEM are derived using Hamilton's principle and based on a moderate deflection theory and accounts for: arbitrary cross-sectional shape, pretwist, generally anisotropic material behavior, transverse shears and out-of-plane warping. Numerical results illustrating the effects of tip sweep, anhedral and composite ply orientation on blade aeroelastic behavior are presented. It is shown that composite ply orientation has a substantial effect on blade stability. At low thrust conditions, certain ply orientations can cause instability in the lag mode. The flap-torsion coupling associated with tip sweep can also induce aeroelastic instability in the blade. This instability can be removed by appropriate ply orientation in the composite construction. These results illustrate the inherent potential for aeroelastic tailoring present in composite rotor blades with swept tips, which still remains to be exploited in the design process.

  7. Aggressive B cell Lymphoma: Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit DLBCL.

    Science.gov (United States)

    Dunleavy, Kieron

    2015-12-01

    Approximately 10% of cases of diffuse large B cell lymphoma (DLBCL) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit lymphomas harbor concurrent rearrangements of MYC and BCL2 and/or BCL6 and are also associated with a very aggressive course and poor clinical outcome. It is unclear and there is lack of consensus on how these diseases should be approached therapeutically. They are characterized typically by high tumor proliferation and likely require Burkitt lymphoma-type strategies and several retrospective studies suggest that more intensive approaches than rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) may be beneficial. One challenge in this respect is that most patients with these diseases are older than 60 years and generally have poor tolerability of regimens typically used in Burkitt lymphoma. Dose-adjusted EPOCH-R is an alternative effective immunochemotherapy platform for DLBCL and is effective in Burkitt lymphoma, and retrospective studies suggest that it is effective and feasible in patients with DLBCL that harbors a MYC rearrangement with or without a BCL-2 translocation (double-hit). A multicenter study of this approach in MYC-rearranged DLBCL is ongoing and preliminary results are very encouraging. There is a lack of consensus on the role of consolidation stem cell transplantation in patients who achieve a good response to initial therapy but at this point in time, no (retrospective) studies have demonstrated any benefit. These diseases are also associated with a high rate of CNS involvement and progression and checking for cerebrospinal fluid by cytology and flow cytometry at initial diagnosis should be considered. In summary, based on retrospective data and preliminary prospective data (as more mature data is awaited), while Burkitt-type regimens may be feasible in young patients, DA-EPOCH-R is a

  8. Straight sinus: ultrastructural analysis aimed at surgical tumor resection.

    Science.gov (United States)

    Amato, Marcelo Campos Moraes; Tirapelli, Luis Fernando; Carlotti, Carlos Gilberto; Colli, Benedicto Oscar

    2016-08-01

    OBJECTIVE Accurate knowledge of the anatomy of the straight sinus (SS) is relevant for surgical purposes. During one surgical procedure involving the removal of part of the SS wall, the authors observed that the venous blood flow was maintained in the SS, possibly through a vein-like structure within the dural sinus or dural multiple layers. This observation and its divergence from descriptions of the histological features of the SS walls motivated the present study. The authors aimed to investigate whether it is possible to dissect the SS walls while keeping the lumen intact, and to describe the histological and ultrastructural composition of the SS wall. METHODS A total of 22 cadaveric specimens were used. The SS was divided into three portions: anterior, middle, and posterior. The characteristics of the SS walls were analyzed, and the feasibility of dissecting them while keeping the SS lumen intact was assessed. The thickness and the number of collagen fibers and other tissues in the SS walls were compared with the same variables in other venous sinuses. Masson's trichrome and Verhoeff's stains were used to assess collagen and elastic fibers, respectively. The data were analyzed using Zeiss image analysis software (KS400). RESULTS A vein-like structure independent of the SS walls was found in at least one of the portions of the SS in 8 of 22 samples (36.36%). The inferior wall could be delaminated in at least one portion in 21 of 22 samples (95.45%), whereas the lateral walls could seldom be delaminated. The inferior wall of the SS was thicker (p < 0.05) and exhibited less collagen and greater amounts of other tissues-including elastic fibers, connective tissue, blood vessels, and nerve fibers (p < 0.05)-compared with the lateral walls. Transmission electron microscopy revealed the presence of muscle fibers at a level deeper than that of the subendothelial connective tissue in the inferior wall of the SS, extending from its junction with the great cerebral vein

  9. Longitudinal relaxation of initially straight flexible and stiff polymers

    Science.gov (United States)

    Dimitrakopoulos, Panagiotis; Dissanayake, Inuka

    2004-11-01

    The present talk considers the relaxation of a single flexible or stiff polymer chain from an initial straight configuration in a viscous solvent. This problem commonly arises when strong flows are turned off in both industrial and biological applications. The problem is also motivated by recent experiments with single biopolymer molecules relaxing after being fully extended by applied forces as well as by the recent development of micro-devices involving stretched tethered biopolymers. Our results are applicable to a wide array of synthetic polymers such as polyacrylamides, Kevlar and polyesters as well as biopolymers such as DNA, actin filaments, microtubules and MTV. In this talk we discuss the mechanism of the polymer relaxation as was revealed through Brownian Dynamics simulations covering a broad range of time scales and chain stiffness. After the short-time free diffusion, the chain's longitudinal reduction at early intermediate times is shown to constitute a universal behavior for any chain stiffness caused by a quasi-steady relaxation of tensions associated with the deforming action of the Brownian forces. Stiff chains are shown to exhibit a late intermediate-time longitudinal reduction associated with a relaxation of tensions affected by the deforming Brownian and the restoring bending forces. The longitudinal and transverse relaxations are shown to obey different laws, i.e. the chain relaxation is anisotropic at all times. In the talk, we show how from the knowledge of the relaxation mechanism, we can predict and explain the polymer properties including the polymer stress and the solution birefringence. In addition, a generalized stress-optic law is derived valid for any time and chain stiffness. All polymer properties which depend on the polymer length are shown to exhibit two intermediate-time behaviors with the early one to constitute a universal behavior for any chain stiffness. This work was supported in part by the Minta Martin Research Fund. The

  10. 49 CFR 238.119 - Rim-stamped straight-plate wheels.

    Science.gov (United States)

    2010-10-01

    ... input to the wheel during braking. (b) A rim-stamped straight-plate wheel shall not be used as a... that is periodically tread-braked for a short duration by automatic circuitry for the sole purpose of...

  11. HIT-6 and MIDAS as measures of headache disability in a headache referral population.

    Science.gov (United States)

    Sauro, Khara M; Rose, Marianne S; Becker, Werner J; Christie, Suzanne N; Giammarco, Rose; Mackie, Gordon F; Eloff, Arnoldas G; Gawel, Marek J

    2010-03-01

    The objective of this study was to compare the headache impact test (HIT-6) and the migraine disability assessment scale (MIDAS) as clinical measures of headache-related disability. The degree of headache-related disability is an important factor in treatment planning. Many quality of life and headache disability measures exist but it is unclear which of the available disability measures is the most helpful in planning and measuring headache management. We compared HIT-6 and MIDAS scores from 798 patients from the Canadian Headache Outpatient Registry and Database (CHORD). Correlation and regression analyses were used to examine the relationships between the HIT-6 and MIDAS total scores, headache frequency and intensity, and Beck Depression Inventory (BDI-II) scores. A positive correlation was found between HIT-6 and MIDAS scores (r = 0.52). The BDI-II scores correlated equally with the HIT-6 and the MIDAS (r = 0.42). There was a non-monotonic relationship between headache frequency and the MIDAS, and a non-linear monotonic relationship between headache frequency and the HIT-6 (r = 0.24). The correlation was higher between the intensity and the HIT-6 scores (r = 0.46), than MIDAS (r = 0.26) scores. Seventy-nine percent of patients fell into the most severe HIT-6 disability category, compared with the 57% of patients that fell into the most severe MIDAS disability category. Significantly more patients were placed in a more severe category with the HIT-6 than with the MIDAS (McNemar chi-square = 191 on 6 d.f., P MIDAS appear to measure headache-related disability in a similar fashion. However, some important differences may exist. Headache intensity appears to influence HIT-6 score more than the MIDAS, whereas the MIDAS was influenced more by headache frequency. Using the HIT-6 and MIDAS together may give a more accurate assessment of a patient's headache-related disability.

  12. Lead generation and examples opinion regarding how to follow up hits.

    Science.gov (United States)

    Orita, Masaya; Ohno, Kazuki; Warizaya, Masaichi; Amano, Yasushi; Niimi, Tatsuya

    2011-01-01

    In fragment-based drug discovery (FBDD), not only identifying the starting fragment hit to be developed but also generating a drug lead from that starting fragment hit is important. Converting fragment hits to leads is generally similar to a high-throughput screening (HTS) hits-to-leads approach in that properties associated with activity for a target protein, such as selectivity against other targets and absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox), and physicochemical properties should be taken into account. However, enhancing the potency of the fragment hit is a key requirement in FBDD, unlike HTS, because initial fragment hits are generally weak. This enhancement is presently achieved by adding additional chemical groups which bind to additional parts of the target protein or by joining or combining two or more hit fragments; however, strategies for effecting greater improvements in effective activity are needed. X-ray analysis is a key technology attractive for converting fragments to drug leads. This method makes it clear whether a fragment hit can act as an anchor and provides insight regarding introduction of functional groups to improve fragment activity. Data on follow-up chemical synthesis of fragment hits has allowed for the differentiation of four different strategies: fragment optimization, fragment linking, fragment self-assembly, and fragment evolution. Here, we discuss our opinion regarding how to follow up on fragment hits, with a focus on the importance of fragment hits as an anchor moiety to so-called hot spots in the target protein using crystallographic data. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Hit-and-run, hit-and-stay, and commensal bacteria present different peptide content when viewed from the perspective of the T cell.

    Science.gov (United States)

    He, Lu; De Groot, Anne S; Bailey-Kellogg, Chris

    2015-11-27

    Different types of bacteria face different pressures from the immune system, with those that persist ("hit-and-stay") potentially having to adapt more in order to escape than those prone to short-lived infection ("hit-and-run"), and with commensal bacteria potentially different from both due to additional physical mechanisms for avoiding immune detection. The Janus Immunogenicity Score (JIS) was recently developed to assess the likelihood of T cell recognition of an antigen, using an analysis that considers both binding of a peptide within the antigen by major histocompatability complex (MHC) and recognition of the peptide:MHC complex by cognate T cell receptor (TCR). This score was shown to be predictive of T effector vs. T regulatory or null responses in experimental data, as well as to distinguish viruses representative of the hit-and-stay vs. hit-and-run phenotypes. Here, JIS-based analyses were conducted in order to characterize the extent to which the pressure to avoid T cell recognition is manifested in genomic differences among representative hit-and-run, hit-and-stay, and commensal bacteria. Overall, extracellular proteins were found to have different JIS profiles from cytoplasmic ones. Contrasting the bacterial groups, extracellular proteins were shown to be quite different across the groups, much more so than intracellular proteins. The differences were evident even at the level of corresponding peptides in homologous protein pairs from hit-and-run and hit-and-stay bacteria. The multi-level analysis of patterns of immunogenicity across different groups of bacteria provides a new way to approach questions of bacterial immune camouflage or escape, as well as to approach the selection and optimization of candidates for vaccine design. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. An advanced straight tube heat exchanger in which a fluid flows at variable and elevated temperatures

    International Nuclear Information System (INIS)

    Mauget, C.; Benoit, G.; Stalport, G.

    1993-01-01

    Straight tube heat exchangers are used as steam generators in nuclear reactors such as in fast neutron nuclear power plants; elevated and highly variable temperatures induce very high thermal expansion constraints in these long straight tubes. In order to avoid the expansion problems, an expansion bellow is disposed between the heat exchanger and the collector tubular plate in such a way that the bundle differential expansions may be absorbed

  15. submitter Influence of 3D Effects on Field Quality in the Straight Part of Accelerator Magnets for the High Luminosity Large Hadron Collider

    CERN Document Server

    Nilsson, Emelie; Todesco, Ezio; Enomoto, Shun; Farinon, Stefania; Fabbricatore, Pasquale; Nakamoto, Tatsushi; Sugano, Michinaka; Savary, Frederic

    2017-01-01

    A dedicated D1 beam separation dipole is currently being developed at KEK for the Large Hadron Collider Luminosity upgrade (HL-LHC). Four 150 mm aperture, 5.6 T magnetic field and 6.7 m long Nb-Ti magnets will replace resistive D1 dipoles. The development includes fabrication and testing of 2.2 m model magnets. The dipole has a single layer coil and thin spacers between coil and iron, giving a non-negligible impact of saturation on field quality at nominal field. The magnetic design of the straight section coil cross section is based on 2D optimization and a separate optimization concerns the coil ends. However, magnetic measurements of the short model showed a large difference (tens of units) between the sextupole harmonic in the straight part and the 2D calculation. This difference is correctly modelled only by a 3D analysis: 3D calculations show that the magnetic field quality in the straight part is influenced by the coil ends, even for the 6.7 m long magnets. The effect is even more remarkable in the sho...

  16. submitter Influence of 3D Effects on Field Quality in the Straight Part of Accelerator Magnets for the High Luminosity Large Hadron Collider

    CERN Document Server

    Nilsson, Emelie; Todesco, Ezio; Enomoto, Shun; Farinon, Stefania; Fabbricatore, Pasquale; Nakamoto, Tatsushi; Sugano, Michinaka; Savary, Frederic

    2018-01-01

    A dedicated D1 beam separation dipole is currently being developed at KEK for the Large Hadron Collider Luminosity upgrade (HL-LHC). Four 150 mm aperture, 5.6 T magnetic field and 6.7 m long Nb-Ti magnets will replace resistive D1 dipoles. The development includes fabrication and testing of 2.2 m model magnets. The dipole has a single layer coil and thin spacers between coil and iron, giving a non-negligible impact of saturation on field quality at nominal field. The magnetic design of the straight section coil cross section is based on 2D optimization and a separate optimization concerns the coil ends. However, magnetic measurements of the short model showed a large difference (tens of units) between the sextupole harmonic in the straight part and the 2D calculation. This difference is correctly modelled only by a 3D analysis: 3D calculations show that the magnetic field quality in the straight part is influenced by the coil ends, even for the 6.7 m long magnets. The effect is even more remarkable in the sho...

  17. Friends with benefits, but without the sex: straight women and gay men exchange trustworthy mating advice.

    Science.gov (United States)

    Russell, Eric M; DelPriore, Danielle J; Butterfield, Max E; Hill, Sarah E

    2013-02-09

    Although research has made progress in elucidating the benefits exchanged within same- and opposite-sex friendships formed between heterosexual men and women, it is less clear why straight women and gay men form close relationships with one another. The current experiments begin to address this question by exploring a potential benefit hypothesized to be uniquely available to straight women and gay men in the context of these friendships: trustworthy mating advice. Experiment 1 revealed that straight women perceive mating-relevant advice from a gay man to be more trustworthy than similar advice offered by a straight man or woman. Experiment 2 demonstrated that gay men perceive mating advice offered by a straight woman to be more trustworthy than advice offered by a lesbian woman or another gay man. Overall, the results provide initial experimental evidence that relationships between gay men and straight women may be characterized by a mutual exchange of mating-relevant benefits in the absence of sexual interest or competition.

  18. Efficient odd straight medium chain free fatty acid production by metabolically engineered Escherichia coli.

    Science.gov (United States)

    Wu, Hui; San, Ka-Yiu

    2014-11-01

    Free fatty acids (FFAs) can be used as precursors for the production of biofuels or chemicals. Different composition of FFAs will be useful for further modification of the biofuel/biochemical quality. Microbial biosynthesis of even chain FFAs can be achieved by introducing an acyl-acyl carrier protein thioesterase gene into E. coli. In this study, odd straight medium chain FFAs production was investigated by using metabolic engineered E. coli carrying acyl-ACP thioesterase (TE, Ricinus communis), propionyl-CoA synthase (Salmonella enterica), and β-ketoacyl-acyl carrier protein synthase III (four different sources) with supplement of extracellular propionate. By using these metabolically engineered E. coli, significant quantity of C13 and C15 odd straight-chain FFAs could be produced from glucose and propionate. The highest concentration of total odd straight chain FFAs attained was 1205 mg/L by the strain HWK201 (pXZ18, pBHE2), and 85% of the odd straight chain FFAs was C15. However, the highest percentage of odd straight chain FFAs was achieved by the strain HWK201 (pXZ18, pBHE3) of 83.2% at 48 h. This strategy was also applied successfully in strains carrying different TE, such as the medium length acyl-ACP thioesterase gene from Umbellularia californica. C11 and C13 became the major odd straight-chain FFAs. © 2014 Wiley Periodicals, Inc.

  19. Friends with Benefits, but without the Sex: Straight Women and Gay Men Exchange Trustworthy Mating Advice

    Directory of Open Access Journals (Sweden)

    Eric M. Russell

    2013-01-01

    Full Text Available Although research has made progress in elucidating the benefits exchanged within same- and opposite-sex friendships formed between heterosexual men and women, it is less clear why straight women and gay men form close relationships with one another. The current experiments begin to address this question by exploring a potential benefit hypothesized to be uniquely available to straight women and gay men in the context of these friendships: trustworthy mating advice. Experiment 1 revealed that straight women perceive mating-relevant advice from a gay man to be more trustworthy than similar advice offered by a straight man or woman. Experiment 2 demonstrated that gay men perceive mating advice offered by a straight woman to be more trustworthy than advice offered by a lesbian woman or another gay man. Overall, the results provide initial experimental evidence that relationships between gay men and straight women may be characterized by a mutual exchange of mating-relevant benefits in the absence of sexual interest or competition.

  20. Comparison of 21G curved and straight phacotips designs in transversal microcoaxial phacoemulsification

    Directory of Open Access Journals (Sweden)

    Süleyman Demircan

    2015-12-01

    Full Text Available AIM:To compare the intraoperative performance and postoperative outcomes after microcoaxial torsional phacoemulsification using the straight and the curved phacotip configurations.METHODS:Cataracts were treated using 2.2mm microcoaxial transversal phacoemulsification with either a 30°straight or 30° curved phaco tip. Intraoperative measurements analyzed included the average ultrasound(U/Spower, the total phacoemulsification time, and the effective phacoemulsification time(EPT. The central endothelial cell density(ECDand the central corneal thickness(CCTwere evaluated preoperatively and postoperatively at 1, 7 and 30d after surgery using noncontact specular microscopy. RESULTS:The study enrolled a total of 190 eyes(190 patients, 95 eyes in the curved tip group and 95 eyes in straight tip group. Intraoperative measurements showed significantly reduced total phacoemulsification time, and EPT in the curved-tip group, compared to the straight-tip group(Pst-3rd quartilesand 18.0(9.0-30.0s in curved-tip group, and 38.8(16.5-73.5s and 26.0(11.0-49.0s in the straight-tip group, respectively. CONCLUSION:Transversal phacoemulsification performed with a curved tip provided more effective lens removal with a less total UST and EPT in all grades, except for grades IV, compared to a straight tip.

  1. 77 FR 57567 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-09-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  2. 77 FR 50690 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-08-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  3. 77 FR 15760 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-03-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  4. 76 FR 39108 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-07-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS ACTION: Notice of... the public. Name of Committee: HIT Policy Committee. General Function of the Committee: to provide...

  5. 77 FR 37407 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-06-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  6. 76 FR 22397 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-04-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  7. 77 FR 22787 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-04-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  8. 77 FR 27459 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-05-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

  9. A C++ object-oriented toolkit for track finding with k-dimensional hits

    International Nuclear Information System (INIS)

    Uiterwijk, J.W.E.; Panman, J.; Vyver, B. van de

    2006-01-01

    A library is described for the recognition of tracks in a set of hits. The hits are assumed to be k-dimensional points (k-d), with k>=1, of which a subset can be grouped into tracks by using short-range correlations. A connection graph between the hits is created by sorting the hits first in k-d space using one of the developed, fast, k-space containers. The track-finding algorithm considers any connection between two hits as a possible track seed and grows these seeds into longer track segments using a modified depth-first search of the connection graph. All hit-acceptance decisions are called via abstract methods of an acceptance criterion class which isolates the library from the application's hit and track model. An application is tuned for a particular tracking environment by creating a concrete implementation for the hit and track acceptance calculations. The implementer is free to trade tracking time for acceptance complexity (influencing efficiency) depending on the requirements of the particular application. Results for simulated data show that the track finding is both efficient and fast even for high noise environments

  10. 76 FR 28783 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-05-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  11. 76 FR 79684 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-12-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  12. 77 FR 73660 - HIT Policy Committee Advisory Meetings; Notice of Meetings

    Science.gov (United States)

    2012-12-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  13. 77 FR 28881 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-05-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

  14. 76 FR 46298 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  15. 77 FR 65691 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-10-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  16. 76 FR 70455 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-11-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

  17. 77 FR 2727 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-01-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  18. 75 FR 21629 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2010-04-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the National Coordinator for Health Information Technology HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Policy Committee...

  19. 76 FR 14975 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: to provide recommendations to...

  20. 76 FR 50734 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-08-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  1. 76 FR 55912 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2011-09-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... the public. Name of Committee: HIT Policy Committee. General Function of the Committee: To provide...

  2. 75 FR 6398 - Office of the National Coordinator for Health Information Technology; HIT Policy Committee's...

    Science.gov (United States)

    2010-02-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the National Coordinator for Health Information Technology; HIT Policy Committee's Adoption/Certification Workgroup Meeting; Notice of Meeting AGENCY: Office... of Committee: HIT Policy Committee's Adoption/Certification Workgroup. General Function of the...

  3. 77 FR 41788 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Science.gov (United States)

    2012-07-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of... of Committee: HIT Policy Committee. General Function of the Committee: To provide recommendations to...

  4. 76 FR 1432 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2011-01-10

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of Meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  5. 75 FR 8954 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-02-26

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  6. 75 FR 70923 - Office of the National Coordinator for Health Information Technology; HIT Policy Committee...

    Science.gov (United States)

    2010-11-19

    ... Technology; HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Policy Committee...

  7. 75 FR 70923 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-11-19

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  8. 75 FR 29761 - Office of the National Coordinator for Health Information Technology: HIT Standards Committee...

    Science.gov (United States)

    2010-05-27

    ... Technology: HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  9. Role of Health Information Technology (HIT) in disability determinations: when medical records become medical evidence.

    Science.gov (United States)

    Tulu, Bengisu; Daniels, Susan; Feldman, Sue; Horan, Thomas A

    2008-11-06

    This exploratory study investigated the impact of incomplete medical evidence on the SSA disability determination process and the role of HIT as a solution. We collected qualitative data from nineteen expert-interviews. Findings indicate that HIT can lead to innovative solutions that can significantly improve the determination process.

  10. Development and psychometric evaluation of the Impact of Health Information Technology (I-HIT) scale.

    Science.gov (United States)

    Dykes, Patricia C; Hurley, Ann; Cashen, Margaret; Bakken, Suzanne; Duffy, Mary E

    2007-01-01

    The use of health information technology (HIT) for the support of communication processes and data and information access in acute care settings is a relatively new phenomenon. A means of evaluating the impact of HIT in hospital settings is needed. The purpose of this research was to design and psychometrically evaluate the Impact of Health Information Technology scale (I-HIT). I-HIT was designed to measure the perception of nurses regarding the ways in which HIT influences interdisciplinary communication and workflow patterns and nurses' satisfaction with HIT applications and tools. Content for a 43-item tool was derived from the literature, and supported theoretically by the Coiera model and by nurse informaticists. Internal consistency reliability analysis using Cronbach's alpha was conducted on the 43-item scale to initiate the item reduction process. Items with an item total correlation of less than 0.35 were removed, leaving a total of 29 items. Item analysis, exploratory principal component analysis and internal consistency reliability using Cronbach's alpha were used to confirm the 29-item scale. Principal components analysis with Varimax rotation produced a four-factor solution that explained 58.5% of total variance (general advantages, information tools to support information needs, information tools to support communication needs, and workflow implications). Internal consistency of the total scale was 0.95 and ranged from 0.80-0.89 for four subscales. I-HIT demonstrated psychometric adequacy and is recommended to measure the impact of HIT on nursing practice in acute care settings.

  11. 76 FR 4354 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2011-01-25

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  12. Visual Illusions and the Control of Ball Placement in Goal-Directed Hitting

    Science.gov (United States)

    Caljouw, Simone R.; Van der Kamp, John; Savelsbergh, Geert J. P.

    2010-01-01

    When hitting, kicking, or throwing balls at targets, online control in the target area is impossible. We assumed this lack of late corrections in the target area would induce an effect of a single-winged Muller-Lyer illusion on ball placement. After extensive practice in hitting balls to different landing locations, participants (N = 9) had to hit…

  13. PageRank, HITS and a unified framework for link analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Chris; He, Xiaofeng; Husbands, Parry; Zha, Hongyuan; Simon, Horst

    2001-10-01

    Two popular webpage ranking algorithms are HITS and PageRank. HITS emphasizes mutual reinforcement between authority and hub webpages, while PageRank emphasizes hyperlink weight normalization and web surfing based on random walk models. We systematically generalize/combine these concepts into a unified framework. The ranking framework contains a large algorithm space; HITS and PageRank are two extreme ends in this space. We study several normalized ranking algorithms which are intermediate between HITS and PageRank, and obtain closed-form solutions. We show that, to first order approximation, all ranking algorithms in this framework, including PageRank and HITS, lead to same ranking which is highly correlated with ranking by indegree. These results support the notion that in web resource ranking indegree and outdegree are of fundamental importance. Rankings of webgraphs of different sizes and queries are presented to illustrate our analysis.

  14. Creating a safe place for pediatric care: A no hit zone.

    Science.gov (United States)

    Frazier, Erin R; Liu, Gilbert C; Dauk, Kelly L

    2014-07-01

    Our goal was to create and implement a program, Kosair Children's Hospital's No Hit Zone, which trains health care workers in de-escalation techniques to address parental disruptive behaviors and physical discipline of children commonly encountered in the hospital environment. The Child Abuse Task Force, a multidisciplinary group, along with key hospital administrators developed specific content for the policy, as well as marketing and educational materials. The No Hit Zone policy designates Kosair Children's Hospital as "an environment in which no adult shall hit a child, no adult shall hit another adult, no child shall hit an adult, and no child shall hit another child. When hitting is observed, it is everyone's responsibility to interrupt the behavior as well as communicate system policy to those present." Via a multidisciplinary, collaborative approach, the No Hit Zone was successfully implemented at Kosair Children's Hospital in 2012. Cost was nominal, and the support of key hospital administrators was critical to the program's success. Education of health professionals on de-escalation techniques and intervention with families at the early signs of parental stress occurred via live sessions and online training via case-based scenarios. The No Hit Zone is an important program used to provide a safe and caring environment for all families and staff of Kosair Children's Hospital. Demand for the program continues, demonstrated by the establishment of No Hit Zones at other local hospitals and multiple outpatient clinics. This article offers information for other organizations planning to conduct similar initiatives. Copyright © 2014 by the American Academy of Pediatrics.

  15. Stochastic, weighted hit size theory of cellular radiobiological action

    International Nuclear Information System (INIS)

    Bond, V.P.; Varma, M.N.

    1982-01-01

    A stochastic theory that appears to account well for the observed responses of cell populations exposed in radiation fields of different qualities and for different durations of exposure is described. The theory appears to explain well most cellular radiobiological phenomena observed in at least autonomous cell systems, argues for the use of fluence rate (phi) instead of absorbed dose for quantification of the amount of radiation involved in low level radiation exposure. With or without invoking the cell sensitivity function, the conceptual improvement would be substantial. The approach suggested also shows that the absorbed dose-cell response functions currently employed do not reflect the spectrum of cell sensitivities to increasing cell doses of a single agent, nor can RBE represent the potency ratio for different agents that can produce similar quantal responses. Thus, for accurate comparison of cell sensitivities among different cells in the same individual, or between the cells in different kinds of individuals, it is necessary to quantify cell sensitivity in terms of the hit size weighting or cell sensitivity function introduced here. Similarly, this function should be employed to evaluate the relative potency of radiation and other radiomimetic chemical or physical agents

  16. Scientific impact: the story of your big hit

    Science.gov (United States)

    Sinatra, Roberta; Wang, Dashun; Deville, Pierre; Song, Chaoming; Barabasi, Albert-Laszlo

    2014-03-01

    A gradual increase in performance through learning and practice characterize most trades, from sport to music or engineering, and common sense suggests this to be true in science as well. This prompts us to ask: what are the precise patterns that lead to scientific excellence? Does performance indeed improve throughout a scientific career? Are there quantifiable signs of an impending scientific hit? Using citation-based measures as a proxy of impact, we show that (i) major discoveries are not preceded by works of increasing impact, nor are followed by work of higher impact, (ii) the precise time ranking of the highest impact work in a scientist's career is uniformly random, with the higher probability to have a major discovery in the middle of scientific careers being due only to changes in productivity, (iii) there is a strong correlation between the highest impact work and average impact of a scientist's work. These findings suggest that the impact of a paper is drawn randomly from an impact distribution that is unique for each scientist. We present a model which allows to reconstruct the individual impact distribution, making possible to create synthetic careers that exhibit the same properties of the real data and to define a ranking based on the overall impact of a scientist. RS acknowledges support from the James McDonnell Foundation.

  17. Preliminary estimates of dose and residual activation of selected components in ring collimation straight of the SNS

    International Nuclear Information System (INIS)

    Ludewig, H.; Catalan-Lasheras, N.; Simos, N.; Walker, J.; Mallen, A.; Wei, J.; Todosow, M.

    2000-01-01

    The highest doses to components in the SNS ring are expected to be to those located in the collimation straight section. In this paper the authors present estimated doses to magnets and cable located between collimators. In addition the buildup of relatively long half-life radioactive isotopes is estimated, following machine operation and shutdown. Finally, the potential dose to operators approaching the machine following operation and shutdown for four hours is made. The results indicate that selected components might require replacement after several years of full power operation. In addition, the reflection of gamma-rays from the tunnel walls contribute a non-negligible amount to the dose of an operator in the tunnel following machine shutdown

  18. Database for High Throughput Screening Hits (dHITS): a simple tool to retrieve gene specific phenotypes from systematic screens done in yeast.

    Science.gov (United States)

    Chuartzman, Silvia G; Schuldiner, Maya

    2018-03-25

    In the last decade several collections of Saccharomyces cerevisiae yeast strains have been created. In these collections every gene is modified in a similar manner such as by a deletion or the addition of a protein tag. Such libraries have enabled a diversity of systematic screens, giving rise to large amounts of information regarding gene functions. However, often papers describing such screens focus on a single gene or a small set of genes and all other loci affecting the phenotype of choice ('hits') are only mentioned in tables that are provided as supplementary material and are often hard to retrieve or search. To help unify and make such data accessible, we have created a Database of High Throughput Screening Hits (dHITS). The dHITS database enables information to be obtained about screens in which genes of interest were found as well as the other genes that came up in that screen - all in a readily accessible and downloadable format. The ability to query large lists of genes at the same time provides a platform to easily analyse hits obtained from transcriptional analyses or other screens. We hope that this platform will serve as a tool to facilitate investigation of protein functions to the yeast community. © 2018 The Authors Yeast Published by John Wiley & Sons Ltd.

  19. Plasma exchange to remove HIT antibodies: dissociation between enzyme-immunoassay and platelet activation test reactivities.

    Science.gov (United States)

    Warkentin, Theodore E; Sheppard, Jo-Ann I; Chu, F Victor; Kapoor, Anil; Crowther, Mark A; Gangji, Azim

    2015-01-01

    Repeated therapeutic plasma exchange (TPE) has been advocated to remove heparin-induced thrombocytopenia (HIT) IgG antibodies before cardiac/vascular surgery in patients who have serologically-confirmed acute or subacute HIT; for this situation, a negative platelet activation assay (eg, platelet serotonin-release assay [SRA]) has been recommended as the target serological end point to permit safe surgery. We compared reactivities in the SRA and an anti-PF4/heparin IgG-specific enzyme immunoassay (EIA), testing serial serum samples in a patient with recent (subacute) HIT who underwent serial TPE precardiac surgery, as well as for 15 other serially-diluted HIT sera. We observed that post-TPE/diluted HIT sera-when first testing SRA-negative-continue to test strongly positive by EIA-IgG. This dissociation between the platelet activation assay and a PF4-dependent immunoassay for HIT antibodies indicates that patients with subacute HIT undergoing repeated TPE before heparin reexposure should be tested by serial platelet activation assays even when their EIAs remain strongly positive. © 2015 by The American Society of Hematology.

  20. Straight configuration saphenous vein transposition to popliteal artery for vascular access.

    Science.gov (United States)

    Caco, Gentian; Golemi, Dhurata; Likaj, Eriola

    2017-03-21

    The saphenous vein is commonly used as a vascular graft in peripheral artery surgery but rarely used for vascular access. The literature on straight configuration saphenous vein transposition to the popliteal artery is scarce. Here we present two cases of straight configuration saphenous vein transposition to the popliteal artery for vascular access, the surgical technique and respective follow-up. Two young men, aged 29 and 36 years, were chosen for lower-limb vascular access for hemodialysis. The first patient was paraplegic since birth. He used his arms to move so upper extremity vascular access was avoided. The second patient presented with an infected upper extremity arteriovenous graft (AVG) and after multiple closed AVFs he had no more available arm veins. Both patients received autologous lower extremity straight configuration saphenous vein transpositions to the popliteal artery under spinal anesthesia in May and October 2012, respectively. Cannulation of the fistula was allowed after one month. There were no early complications. Slight swelling on the leg appeared in one of the patients. Both fistulas were still functional after 36 and 32 months, respectively. The straight configuration saphenous vein transposition to popliteal artery is simple to perform, offers a long and straight segment for cannulation and may be a suitable autologous vascular access in selected patients.

  1. Investigation into the limitations of straightness interferometers using a multisensor-based error separation method

    Science.gov (United States)

    Weichert, Christoph; Köchert, Paul; Schötka, Eugen; Flügge, Jens; Manske, Eberhard

    2018-06-01

    The uncertainty of a straightness interferometer is independent of the component used to introduce the divergence angle between the two probing beams, and is limited by three main error sources, which are linked to each other: their resolution, the influence of refractive index gradients and the topography of the straightness reflector. To identify the configuration with minimal uncertainties under laboratory conditions, a fully fibre-coupled heterodyne interferometer was successively equipped with three different wedge prisms, resulting in three different divergence angles (4°, 8° and 20°). To separate the error sources an independent reference with a smaller reproducibility is needed. Therefore, the straightness measurement capability of the Nanometer Comparator, based on a multisensor error separation method, was improved to provide measurements with a reproducibility of 0.2 nm. The comparison results revealed that the influence of the refractive index gradients of air did not increase with interspaces between the probing beams of more than 11.3 mm. Therefore, over a movement range of 220 mm, the lowest uncertainty was achieved with the largest divergence angle. The dominant uncertainty contribution arose from the mirror topography, which was additionally determined with a Fizeau interferometer. The measured topography agreed within  ±1.3 nm with the systematic deviations revealed in the straightness comparison, resulting in an uncertainty contribution of 2.6 nm for the straightness interferometer.

  2. Lower bounds on the periodic Hamming correlations of frequency hopping sequences with low hit zone

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In this paper, several periodic Hamming correlation lower bounds for frequency hopping sequences with low hit zone, with respect to the size p of the frequency slot set, the sequence length L, the family size M, low hit zone LH ( or no hit zone NH ), the maximum periodic Hamming autocorrelation sidelobe Ha and the maximum periodic Hamming crosscorrelation Hc, are established. It is shown that the new bounds include the known Lempel-Greenberger bounds, T.S. Seay bounds and Peng-Fan bounds for the conventional frequency hopping sequences as special cases.

  3. The UV-FEL at the NSLS: Straight injection configuration

    International Nuclear Information System (INIS)

    Zhang, Xiaohao; Gallardo, J.C.

    1993-01-01

    We present a design of a colinear RF-photocathode gun and linac sections for the ultraviolet free-electron laser under study at the National Synchrotron Light Source. Inverse Helmholtz solenoid pair is used to control the divergence of the electron beam and present a slightly convergent and small beam into a conventional SLAC linac. The relative distance of the gun to the linac and the strength of the solenoidal field are chosen to minimize the emittance growth of the beam due to space charge. The simulation codes PARMELA and TRACE-3D are used to model the beam from the cathode to the entrance to the wiggler

  4. Neck Muscle Moment Arms Obtained In-Vivo from MRI: Effect of Curved and Straight Modeled Paths.

    Science.gov (United States)

    Suderman, Bethany L; Vasavada, Anita N

    2017-08-01

    Musculoskeletal models of the cervical spine commonly represent neck muscles with straight paths. However, straight lines do not best represent the natural curvature of muscle paths in the neck, because the paths are constrained by bone and soft tissue. The purpose of this study was to estimate moment arms of curved and straight neck muscle paths using different moment arm calculation methods: tendon excursion, geometric, and effective torque. Curved and straight muscle paths were defined for two subject-specific cervical spine models derived from in vivo magnetic resonance images (MRI). Modeling neck muscle paths with curvature provides significantly different moment arm estimates than straight paths for 10 of 15 neck muscles (p straight lines to model muscle paths can lead to overestimating neck extension moment. However, moment arm methods for curved paths should be investigated further, as different methods of calculating moment arm can provide different estimates.

  5. Synthesis method based on solution regions for planar four bar straight line linkages

    International Nuclear Information System (INIS)

    Lai Rong, Yin; Cong, Mao; Jian you, Han; Tong, Yang; Juan, Huang

    2012-01-01

    An analytical method for synthesizing and selecting desired four-bar straight line mechanisms based on solution regions is presented. Given two fixed pivots, the point position and direction of the target straight line, an infinite number of mechanism solutions can be produced by employing this method, both in the general case and all three special cases. Unifying the straight line direction and the displacement from the given point to the instant center into the same form with different angles as parameters, infinite mechanism solutions can be expressed with different solution region charts. The mechanism property graphs have been computed to enable the designers to find out the involved mechanism information more intuitively and avoid aimlessness in selecting optimal mechanisms

  6. Novel Straight and Circular Road Driving Control of Electric Power Assisted Wheelchair Based on Fuzzy Algorithm

    Science.gov (United States)

    Seki, Hirokazu; Tadakuma, Susumu

    This paper describes a novel straight and circular road driving control scheme for electric power assisted wheelchairs. “Electric power assisted wheelchair” which assists the driving force by electric motors is expected to be widely used as a mobility support system for elderly people and disabled people, however, the performance of the straight and circular road driving must be further improved because the two wheels drive independently. This paper proposes a novel driving control scheme based on fuzzy algorithm to realize the stable and reliable driving on straight and circular roads. The suitable assisted torque of the right and left wheels is determined by fuzzy algorithm based on the posture angular velocity of the wheelchair and the human input torque proportion of the right and left wheels. Some experiments on the practical roads show the effectiveness of the proposed control system.

  7. Controllable synthesis of helical, straight, hollow and nitrogen-doped carbon nanofibers and their magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xun [State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructure, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China); State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008 (China); Xu, Zheng, E-mail: zhengxu@nju.edu.cn [State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructure, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China)

    2012-12-15

    Graphical abstract: The helical, straight and hollow carbon nanofibers can be selectively synthesized by adjusting either the reaction temperature or feed gas composition. Display Omitted Highlights: ► CNFs were synthesized via pyrolysis of acetylene on copper NPs. ► The helical, straight, hollow and N-doped CNFs can be selectively synthesized. ► The growth mechanism of different types of CNFs was proposed. -- Abstract: Carbon nanofibers (CNFs) with various morphologies were synthesized by catalytic pyrolysis of acetylene on copper nanoparticles which were generated from the in situ decomposition of copper acetylacetonate. The morphology of the pristine and acid-washed CNFs was investigated by field emission scanning electron microscope and high-resolution transmission electron microscope. Helical, straight and hollow CNFs can be selectively synthesized by adjusting either the reaction temperature or feed gas composition. The growth mechanism for these three types of CNFs was proposed.

  8. "Appearance potent"? A content analysis of UK gay and straight men's magazines.

    Science.gov (United States)

    Jankowski, Glen S; Fawkner, Helen; Slater, Amy; Tiggemann, Marika

    2014-09-01

    With little actual appraisal, a more 'appearance potent' (i.e., a reverence for appearance ideals) subculture has been used to explain gay men's greater body dissatisfaction in comparison to straight men's. This study sought to assess the respective appearance potency of each subculture by a content analysis of 32 issues of the most read gay (Attitude, Gay Times) and straight men's magazines (Men's Health, FHM) in the UK. Images of men and women were coded for their physical characteristics, objectification and nudity, as were the number of appearance adverts and articles. The gay men's magazines featured more images of men that were appearance ideal, nude and sexualized than the straight men's magazines. The converse was true for the images of women and appearance adverts. Although more research is needed to understand the effect of this content on the viewer, the findings are consistent with a more appearance potent gay male subculture. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  9. Long-term operation experience with 2 ECR ion sources and planned extensions at HIT

    International Nuclear Information System (INIS)

    Winkelmann, T.; Cee, R.; Haberer, T.; Naas, B.; Peters, A.

    2012-01-01

    The HIT (Heidelberg Ion Beam Therapy Center) is the first treatment facility at a hospital in Europe where patients can be treated with protons and carbon ions. Since the commissioning starting in 2006 two 14.5 GHz electron cyclotron resonance ion sources are routinely used to produce a variety of ion beams from protons up to oxygen. The operating time is 330 days per year, our experience after three years of continuous operation will be presented. In the future a helium beam for patient treatment is requested, therefore a third ion source will be integrated. This third ECR source with a newly designed extraction system and a spectrometer line will be installed at a test-bench to commission and validate this section. Different test settings are foreseen to study helium operation as well as enhanced parameter sets for proton and carbon beams in combination with a modified beam transport line for higher transmission efficiency. An outlook to the possible integration scheme of the new ion source into the production facility will be discussed. The paper is followed by the associated poster. (authors)

  10. The T10 beam produces a few hits per event. In ALICE the SSD will have to cope with many hits per strip. In the three centimeters of aluminium the beam will produce many secondary particles. This increases the chance of multiple hits per strip, although not to the level in ALICE.

    CERN Multimedia

    Nooren, G.

    2004-01-01

    The T10 beam produces a few hits per event. In ALICE the SSD will have to cope with many hits per strip. In the three centimeters of aluminium the beam will produce many secondary particles. This increases the chance of multiple hits per strip, although not to the level in ALICE.

  11. Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.

    Science.gov (United States)

    Deshpande, Anita S; Wendell Todd, N

    2016-12-01

    To describe the straight-into-cochlea line that affords the best access for an electrode array to enter via the round window, and how this line relates to the facial nerve, the incus, and mastoid size. The straight-into-cochlea line is important to minimize the cochlear trauma and maximize the likelihood of placement into the scala tympani. High-resolution CT scans were obtained for ten craniums with the extremes of large (N = 5) and small (N = 5) mastoid pneumatization; the specimens were from a series of 41 ear normal craniums. Using FIJI, a publicly available software program, the straight-into-cochlea insertion line was determined by defining the x-y-z coordinates of the middle of the round window and a point 6.0 mm into the cochlea on its centrifugal wall. Then, from the extended straight-into-cochlea insertion line, we determined the shortest perpendicular distance to the middle of the fallopian canal, and from that "fallopian point" to the apex of the posterior process of the incus. We found good repeatability of measurements. We found the extended straight-into-cochlea insertion lines routinely close to or in the midst of the fallopian canal (50 % ≤ 1.0 mm). We found the lines 4.7-7.8 mm from the apex of the posterior process of the incus. Line positions relative to "fallopian point" and incus showed no relation to mastoid pneumatization. For the distance "fallopian point" to incus, bilateral symmetry was suggested. Using landmarks registered in an x-y-z coordinate system, straight-into-cochlea insertion via the round window puts the facial nerve at risk.

  12. Radiologic findings of deep seated cerebral arteriovenous malformation with nonvisualization of straight sinus: focused on angiogram

    International Nuclear Information System (INIS)

    Won, Jong Boo; Park, Sung Ho; Hong, Jong Won; Kim, Yoo Kyoung; Shin, Mi Jeong; Baik, Seung Kuk; Choi, Han Yong; Kim, Bong Gi

    1999-01-01

    To analyze the radiologic-especially angiographic-findings of deep seated cerebral arteriovenous malformation(AVM) involving nonvisualized straight sinus. In six patients aged between 15 and 53 years with deep seated cerebral AVM, CT and MR images were retrospectively analyzed with regard to the following features : the presence of straight sinus, the location of AVM, and the occurrence of hemorrhage. Angiograms were analyzed for venous drainage routes of AVM, the appearance of veins, the presence of falcine sinus and venous drainage from normal deep brain parenchyme. In four patients who had undergone intravascular embolization therapy, pre- and post- embolization angiograms were compared. CT and MR images showed neither straight sinus nor thrombosis. AVMs were deeply seated in the brain, and in all cases there was cerebral hemorrhage. Angiograms disclosed that venous drainage of all AVMs occurred via the veins of Galen. In one case, venous flow via the falcine sinus to the superior sagittal sinus was noted, but in others, retrograde flow in the deep venous system was observed. Marked collateral routes followed in response to the obstruction of straight sinus included the basal vein of Rosenthal, the internal occipital, internal cerebral, and cerebellar hemispheric veins (which are Galenic afferents), and the inferior sagittal sinus. In all patients, contralateral routes were partially involved. Venous drainage from normal deep parenchyme through the transcerebral veins to the superficial venous system was noted, and in one case, straight sinus which had been observed on an angiogram five years earlier was no longer present. Angiography offers effective evaluation of the dynamic aspect of venous flow in cases involving deep-seated AVM, and of normal deep parenchyme in cases in which AVM involves nonvisualized straight sinus. Before intravascular treatment of AVM, venous flow must be carefully analyzed

  13. Straight and chopped DC performance data for a reliance EV-250AT motor with a General Electric EV-1 controller

    Science.gov (United States)

    Edie, P. C.

    1981-01-01

    Straight and chopped DC motor performances for a Reliance EV-250AT motor with an EV-1 controller were examined. Effects of motor temperature and operating voltage are shown. It is found that the maximum motor efficiency is approximately 85% at low operating temperatures in the straight DC mode. Chopper efficiency is 95% under all operating conditions. For equal speeds, the motor operated in the chopped mode develops slightly more torque and draws more current than it does in the straight DC mode.

  14. Cubic systems with invariant affine straight lines of total parallel multiplicity seven

    Directory of Open Access Journals (Sweden)

    Alexandru Suba

    2013-12-01

    Full Text Available In this article, we study the planar cubic differential systems with invariant affine straight lines of total parallel multiplicity seven. We classify these system according to their geometric properties encoded in the configurations of invariant straight lines. We show that there are only 17 different topological phase portraits in the Poincar\\'e disc associated to this family of cubic systems up to a reversal of the sense of their orbits, and we provide representatives of every class modulo an affine change of variables and rescaling of the time variable.

  15. A potential flow 2-D vortex panel model: Applications to vertical axis straight blade tidal turbine

    International Nuclear Information System (INIS)

    Wang, L.B.; Zhang, L.; Zeng, N.D.

    2007-01-01

    A potential flow 2-D vortex panel model (VPM2D) for unsteady hydrodynamics calculation of the vertical axis straight blade variable pitch turbine was given for tidal streams energy conversion. Numerical results of predicted instantaneous blade forces and wake flow of the rotor showed good agreement with the test data. The model was also compared with the previous classic free vortex model (V-DART) and vortex method combined with finite element analysis (FEVDTM). It showed that the present model was much better than the former, less complex than the latter and suitable for designing and optimization of the vertical axis straight blade turbine

  16. The appearance potency of gay and straight men’s websites

    OpenAIRE

    Jankowski, G.; Slater, A.; Tiggemann, M.; Fawkner, H.

    2016-01-01

    Gay men's greater body dissatisfaction compared to straight men has been explained as a result of gay men’s more 'appearance potent' subculture. This study aimed to critically appraise this explanation by assessing images of men and women for their physical characteristics and objectification across 8 popular gay and straight men's dating and porn websites. 1,415 images of men and 715 images of women across the website’s main pages were coded. Results showed that the gay men's websites featur...

  17. The Planning of Straight Line Trajectory in Robotics Using Interactive Graphics

    Directory of Open Access Journals (Sweden)

    Kesheng Wang

    1987-07-01

    Full Text Available The planning of straight line trajectory using the interactive computer graphics simulation of robot manipulator movement is discussed. This new approach to straight line motion planning improves the 'bound deviation joint paths' developed by R. M. Taylor (1979. The new approach has three characteristics: (1 linear interpolation in joint space; (2 unequal intervals for interpolating knot points; (3 using interactive computer graphics to assure that the maximum deviation in the whole segment is less than the pre-specified values. The structure and mathematical basis of a computer program developed for this purpose are presented.

  18. Gender, Health Behavior, and Intimate Relationships: Lesbian, Gay, and Straight Contexts

    OpenAIRE

    Reczek, Corinne; Umberson, Debra

    2011-01-01

    Many studies focus on health behavior within the context of intimate ties. However, this literature is limited by reliance on gender socialization theory and a focus on straight (i.e., heterosexual) marriage. We extend this work with an analysis of relationship dynamics around health behavior in 20 long-term straight marriages as well as 15 gay and 15 lesbian long-term cohabiting partnerships in the United States (N=100 individual in-depth interviews). We develop the concept of “health behavi...

  19. Shielded transient self-interaction of a bunch entering a circle from a straight path

    International Nuclear Information System (INIS)

    Li, R.; Bohn, C.L.; Bisognano, J.J.

    1997-01-01

    When a short (mm-length) bunch with high (nC-regime) charge is transported through a magnetic bending system, self-interaction via coherent synchrotron radiation (CSR) and space charge may alter the bunch dynamics significantly. The authors consider a Gaussian rigid-line-charge bunch following a straight-path trajectory into a circle, with the trajectory centered between two infinite, parallel, perfectly conducting plates. Transients associated with CSR and space charge generated from source particles both on the straight path and the circle are calculated, and their net effect on the radiated power is contrasted with that of shielded steady-state CSR

  20. Efficiency Improvement of HIT Solar Cells on p-Type Si Wafers.

    Science.gov (United States)

    Wei, Chun-You; Lin, Chu-Hsuan; Hsiao, Hao-Tse; Yang, Po-Chuan; Wang, Chih-Ming; Pan, Yen-Chih

    2013-11-22

    Single crystal silicon solar cells are still predominant in the market due to the abundance of silicon on earth and their acceptable efficiency. Different solar-cell structures of single crystalline Si have been investigated to boost efficiency; the heterojunction with intrinsic thin layer (HIT) structure is currently the leading technology. The record efficiency values of state-of-the art HIT solar cells have always been based on n-type single-crystalline Si wafers. Improving the efficiency of cells based on p-type single-crystalline Si wafers could provide broader options for the development of HIT solar cells. In this study, we varied the thickness of intrinsic hydrogenated amorphous Si layer to improve the efficiency of HIT solar cells on p-type Si wafers.

  1. High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors.

    Science.gov (United States)

    Myers, Stephanie M; Bawn, Ruth H; Bisset, Louise C; Blackburn, Timothy J; Cottyn, Betty; Molyneux, Lauren; Wong, Ai-Ching; Cano, Celine; Clegg, William; Harrington, Ross W; Leung, Hing; Rigoreau, Laurent; Vidot, Sandrine; Golding, Bernard T; Griffin, Roger J; Hammonds, Tim; Newell, David R; Hardcastle, Ian R

    2016-08-08

    The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of 57 617 compounds. Four distinct chemical series were evident within the screening hits. Resynthesis and reassay of the hits demonstrated that one series did not return active compounds, whereas three series returned active hits. Structure-activity studies demonstrated that the 4-benzoylpyrrole-2-carboxamide pharmacophore had excellent potential for further development. The minimum kinase binding pharmacophore was identified, and key examples demonstrated good selectivity for ERK5 over p38α kinase.

  2. Optimal Fixed-Interval Integrated Guidance-Control Laws for Hit-to-Kill Missiles

    National Research Council Canada - National Science Library

    Menon, P. K; Sweriduk, G. D; Ohlmeyer, E. J

    2003-01-01

    Due to their potential for reducing the weapon size and efficiency, design methods for realizing hit-to- kill capabilities in missile systems are of significant research interest in the missile flight control community...

  3. 75 FR 32472 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-06-08

    ... Coordinator for Health Information Technology AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of committee recommendations and invitation for public input... Coordinator for Health Information Technology (ONC). Name of Committee: HIT Standards Committee. General...

  4. HIT or miss? A comprehensive contemporary investigation of laboratory tests for heparin induced thrombocytopenia.

    Science.gov (United States)

    Favaloro, Emmanuel J; McCaughan, Georgia; Mohammed, Soma; Lau, Kun Kan Edwin; Gemmell, Rosalie; Cavanaugh, Lauren; Donikian, Dea; Kondo, Mayuko; Brighton, Timothy; Pasalic, Leonardo

    2018-04-17

    Heparin induced thrombocytopenia (HIT) is a rare but potentially fatal complication of heparin therapy, which in a proportion of patients causes platelet activation and thrombosis. Initial clinical assessment of the likelihood of HIT is facilitated by laboratory testing to confirm or exclude HIT. This prospective investigation was performed over an 18-month period, and has involved testing of over 300 test samples from over 100 consecutive patients. Clinical assessment by 4T score was supplemented by laboratory tests that comprised both immunological [lateral flow ('STiC'), chemiluminescence (AcuStar; HIT-IgG (PF4-H) ), ELISA (Asserachrom HPIA IgG)] and functional assays [SRA, platelet aggregation using whole blood ('Multiplate') and platelet rich plasma ('LTA')]. We observed both false positive and false negative test findings with most assays. Overall, the whole blood aggregation method provided a reasonable alternative to SRA for identifying functional HIT. STiC, AcuStar and ELISA procedures were fairly comparable in terms of screening for HIT, although STiC and AcuStar both yielded false negatives, albeit also resulting in fewer false positives than ELISA. The 4T score had less utility in our patient cohort than we were expecting, although there was an association with the likelihood of HIT. Nevertheless, we accept that our observations are based on limited test numbers. In conclusion, no single approach (clinical or laboratory) was associated with optimal sensitivity or specificity of HIT exclusion or identification, and thus, a combination of clinical evaluation and laboratory testing will best ensure the accuracy of diagnosis. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

  5. Simulation optimizing of n-type HIT solar cells with AFORS-HET

    Science.gov (United States)

    Yao, Yao; Xiao, Shaoqing; Zhang, Xiumei; Gu, Xiaofeng

    2017-07-01

    This paper presents a study of heterojunction with intrinsic thin layer (HIT) solar cells based on n-type silicon substrates by a simulation software AFORS-HET. We have studied the influence of thickness, band gap of intrinsic layer and defect densities of every interface. Details in mechanisms are elaborated as well. The results show that the optimized efficiency reaches more than 23% which may give proper suggestions to practical preparation for HIT solar cells industry.

  6. HIT Solar Cells with N-Type Low-Cost Metallurgical Si

    Directory of Open Access Journals (Sweden)

    Xing Yang

    2018-01-01

    Full Text Available A conversion efficiency of 20.23% of heterojunction with intrinsic thin layer (HIT solar cell on 156 mm × 156 mm metallurgical Si wafer has been obtained. Applying AFORS-HET software simulation, HIT solar cell with metallurgical Si was investigated with regard to impurity concentration, compensation level, and their impacts on cell performance. It is known that a small amount of impurity in metallurgical Si materials is not harmful to solar cell properties.

  7. MYC/BCL2/BCL6 triple hit lymphoma: a study of 40 patients with a comparison to MYC/BCL2 and MYC/BCL6 double hit lymphomas.

    Science.gov (United States)

    Huang, Wenting; Medeiros, L Jeffrey; Lin, Pei; Wang, Wei; Tang, Guilin; Khoury, Joseph; Konoplev, Sergej; Yin, C Cameron; Xu, Jie; Oki, Yasuhiro; Li, Shaoying

    2018-05-21

    High-grade B-cell lymphomas with MYC, BCL2, and BCL6 rearrangements (triple hit lymphoma) are uncommon. We studied the clinicopathologic features of 40 patients with triple hit lymphoma and compared them to 157 patients with MYC/BCL2 double hit lymphoma and 13 patients with MYC/BCL6 double hit lymphoma. The triple hit lymphoma group included 25 men and 15 women with a median age of 61 years (range, 34-85). Nine patients had a history of B-cell lymphoma. Histologically, 23 (58%) cases were diffuse large B-cell lymphoma and 17 cases had features of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Most cases of triple hit lymphoma were positive for CD10 (100%), BCL2 (95%), BCL6 (82%), MYC (74%), and 71% with MYC and BCL2 coexpression. P53 was overexpressed in 29% of triple hit lymphoma cases. The clinicopathological features of triple hit lymphoma patients were similar to patients with MYC/BCL2 and MYC/BCL6 double hit lymphoma, except that triple hit lymphoma cases were more often CD10 positive compared with MYC/BCL6 double hit lymphoma (p hit lymphoma and double hit lymphoma and overall survival in triple hit lymphoma patients was 17.6 months, similar to the overall survival of patients with double hit lymphoma (p = 0.67). Patients with triple hit lymphoma showing P53 overexpression had significantly worse overall survival compared with those without P53 overexpression (p = 0.04). On the other hand, double expressor status and prior history of B-cell lymphoma did not correlate with overall survival. In conclusion, most patients with triple hit lymphoma have an aggressive clinical course and poor prognosis and these tumors have a germinal center B-cell immunophenotype, similar to patients with double hit lymphomas. P53 expression is a poor prognostic factor in patients with triple hit lymphoma.

  8. Planning and Arun's (not so Straight and Narrow Roads

    Directory of Open Access Journals (Sweden)

    Jeannie van Wyk

    2016-04-01

    Full Text Available Arun Property Development (Pty Ltd wished to subdivide portions of the farm Langeberg 311, Durbanville. The 1988 structure plan for the area had indicated that certain roads would traverse the property. These and other roads all formed part of a new subdivision known as Sonstraal Heights. As is customary, the ownership of the roads in the subdivision vested in the municipality in terms of section 28 of the Land Use Planning Ordinance 15 of 1985 (C (LUPO on the date of approval of the subdivision. Central to this provision is that no compensation is payable to the developer if the provision of the public roads is based on the normal need therefor arising from the subdivision. Since the developer was of the opinion that the roads it had provided exceeded the normal need, the issue that had to be resolved was whether compensation must be paid for roads beyond what would normally be required for a subdivision. The main issue that the courts, from the Western Cape High Court to the Constitutional Court in Arun Property Development (Pty Ltd v City of Cape Town 2015 2 SA 584 (CC, had to deal with was whether the vesting of roads beyond the normal need therefor arising from the subdivision amounted to an expropriation of land for which compensation is payable in terms of section 25(2 of the Constitution. This case note looks at the different stages of the case, and in the process highlights the historical and legislative background and the subdivision process. It shows that the vesting of the ownership of roads in the municipality is similar to the payment of a development contribution, both of which can be categorised as deprivations of property in terms of the constitutional property clause. On 1 July 2015 LUPO was effectively superseded by the new Spatial Planning and Land Use Management Act 16 of 2013 (SPLUMA and the Western Cape Land Use Planning Act 3 of 2014 (LUPA. Since SPLUMA does not and LUPA does contain a reference to the "normal needs

  9. Platelet count recovery and seroreversion in immune HIT despite continuation of heparin: further observations and literature review.

    Science.gov (United States)

    Shih, Andrew W; Sheppard, Jo-Ann I; Warkentin, Theodore E

    2017-10-05

    One of the standard distinctions between type 1 (non-immune) and type 2 (immune-mediated) heparin-induced thrombocytopenia (HIT) is the transience of thrombocytopenia: type 1 HIT is viewed as early-onset and transient thrombocytopenia, with platelet count recovery despite continuing heparin administration. In contrast, type 2 HIT is viewed as later-onset (i. e., 5 days or later) thrombocytopenia in which it is generally believed that platelet count recovery will not occur unless heparin is discontinued. However, older reports of type 2 HIT sometimes did include the unexpected observation that platelet counts could recover despite continued heparin administration, although without information provided regarding changes in HIT antibody levels in association with platelet count recovery. In recent years, some reports of type 2 HIT have confirmed the observation that platelet count recovery can occur despite continuing heparin administration, with serological evidence of waning levels of HIT antibodies ("seroreversion"). We now report two additional patient cases of type 2 HIT with platelet count recovery despite ongoing therapeutic-dose (1 case) or prophylactic-dose (1 case) heparin administration, in which we demonstrate concomitant waning of HIT antibody levels. We further review the literature describing this phenomenon of HIT antibody seroreversion and platelet count recovery despite continuing heparin administration. Our observations add to the concept that HIT represents a remarkably transient immune response, including sometimes even when heparin is continued.

  10. USER FRUSTRATION IN HIT INTERFACES: EXPLORING PAST HCI RESEARCH FOR A BETTER UNDERSTANDING OF CLINICIANS' EXPERIENCES.

    Science.gov (United States)

    Opoku-Boateng, Gloria A

    2015-01-01

    User frustration research has been one way of looking into clinicians' experience with health information technology use and interaction. In order to understand how clinician frustration with Health Information Technology (HIT) use occurs, there is the need to explore Human-Computer Interaction (HCI) literature that addresses both frustration and HIT use. In the past three decades, HCI frustration research has increased and expanded. Researchers have done a lot of work to understand emotions, end-user frustration and affect. This paper uses a historical literature review approach to review the origins of emotion and frustration research and explore the research question; Does HCI research on frustration provide insights on clinicians' frustration with HIT interfaces? From the literature review HCI research on emotion and frustration provides additional insights that can indeed help explain user frustration in HIT. Different approaches and HCI perspectives also help frame HIT user frustration research as well as inform HIT system design. The paper concludes with a suggested directions on how future design and research may take.

  11. "Hit-and-Run" leaves its mark: catalyst transcription factors and chromatin modification.

    Science.gov (United States)

    Varala, Kranthi; Li, Ying; Marshall-Colón, Amy; Para, Alessia; Coruzzi, Gloria M

    2015-08-01

    Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a "Hit-and-Run" model of transcription. In this model, a master TF "hits" a target promoter to initiate a rapid response to a signal. As the "hit" is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the "run", the master TF "hits" other targets to propagate the response genome-wide. As such, a TF may act as a "catalyst" to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This "Hit-and-Run" model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this "Hit-and-Run" model to suggest molecular mechanisms and its biological relevance. © 2015 The Authors. Bioessays published by WILEY Periodicals, Inc.

  12. The impact of Health Information Technology (I-HIT) Scale: the Australian results.

    Science.gov (United States)

    Cook, Robyn; Foster, Joanne

    2009-01-01

    One of role of the nurse in the clinical setting is that of co-ordinating communication across the healthcare team. On a daily basis nurses interact with the person receiving care, their family members, and multiple care providers thus placing the nurse in the central position with access to a vast array of information on the person. Through this nurses have historically functioned as "information repositories". With the advent of Health Information Technology (HIT) tools there is a potential that HIT could impact interdisciplinary communication, practice efficiency and effectiveness, relationships and workflow in acute care settings [1][3]. In 2005, the HIMSS Nursing Informatics Community developed the I-HIT Scale to measure the impact of HIT on the nursing role and interdisciplinary communication in USA hospitals. In 2007, nursing informatics colleagues from Australia, Finland, Ireland, New Zealand, Scotland and the USA formed a research collaborative to validate the I-HIT in six additional countries. This paper will discuss the background, methodology, results and implications from the Australian I-HIT survey of over 1,100 nurses. The results are currently being analyzed and will be presented at the conference.

  13. Are stripes beneficial? Dazzle camouflage influences perceived speed and hit rates.

    Directory of Open Access Journals (Sweden)

    Bettina von Helversen

    Full Text Available In the animal kingdom, camouflage refers to patterns that help potential prey avoid detection. Mostly camouflage is thought of as helping prey blend in with their background. In contrast, disruptive or dazzle patterns protect moving targets and have been suggested as an evolutionary force in shaping the dorsal patterns of animals. Dazzle patterns, such as stripes and zigzags, are thought to reduce the probability with which moving prey will be captured by impairing predators' perception of speed. We investigated how different patterns of stripes (longitudinal-i.e., parallel to movement direction-and vertical-i.e., perpendicular to movement direction affect the probability with which humans can hit moving objects and if differences in hitting probability are caused by a misperception of speed. A first experiment showed that longitudinally striped objects were hit more often than unicolored objects. However, vertically striped objects did not differ from unicolored objects. A second study examining the link between perceived speed and hitting probability showed that longitudinally and vertically striped objects were both perceived as moving faster and were hit more often than unicolored objects. In sum, our results provide evidence that striped patterns disrupt the perception of speed, which in turn influences how often objects are hit. However, the magnitude and the direction of the effects depend on additional factors such as speed and the task setup.

  14. Darboux integrability and rational reversibility in cubic systems with two invariant straight lines

    Directory of Open Access Journals (Sweden)

    Dumitru Cozma

    2013-01-01

    Full Text Available We find conditions for a singular point O(0,0 of a center or a focus type to be a center, in a cubic differential system with two distinct invariant straight lines. The presence of a center at O(0,0 is proved by using the method of Darboux integrability and the rational reversibility.

  15. Understanding the Active Straight Leg Raise (ASLR): An electromyographic study in healthy subjects

    NARCIS (Netherlands)

    Hu, H.; Meijer, O.G.; Bruijn, S.M.; Strijers, R.L.M.; Nanayakkara, P.W.B.; van Royen, B.J.; Wu, W; Xia, C.; van Dieen, J.H.

    2012-01-01

    The Active Straight Leg Raise (ASLR) is an important test in diagnosing pelvic girdle pain (PGP). It is difficult to understand what happens normally during the ASLR, let alone why it would be impaired in PGP. In the present study, healthy subjects performed the ASLR under normal conditions, with

  16. MORPION: a fast hardware processor for straight line finding in MWPC

    International Nuclear Information System (INIS)

    Mur, M.

    1980-02-01

    A fast hardware processor for straight line finding in MWPC has been built in Saclay and successfully operated in the NA3 experiment at CERN. We give the motivations to build this processor, and describe the hardware implementation of the line finding algorithm. Finally its use and performance in NA3 are described

  17. Straight-line assimilation in home-leaving? A comparison of Turks, Somalis and Danes

    DEFF Research Database (Denmark)

    Nielsen, Rikke Skovgaard

    2016-01-01

    The purpose of this paper is to test the evidence for spatial assimilation and straight-line assimilation in the transition of leaving home in Denmark. Based on data from the extensive Danish registers, the paper analyses the home-leaving patterns of Danes, Turkish immigrants, Turkish descendants...

  18. Straight-leg rasing in 'short hamstrings'. An experimental study of muscle elasticy and defense reactions.

    NARCIS (Netherlands)

    Göeken, Ludwig Nanno Hiltjo

    1988-01-01

    The central guestion asked in this thesis is whether an Experimental Straight-Leg Raising test (E.S.L.R.) can contribute to the solution of a diagnostical problem frequently encountered in rehabilitation medicine. It concerns the determination of the cause of the movement restriction in patients who

  19. Effect of Hartmann layer resolution for MHD flow in a straight ...

    Indian Academy of Sciences (India)

    851–861. c Indian Academy of Sciences. Effect of Hartmann layer resolution for MHD flow in a straight, conducting duct at high Hartmann numbers. SHARANYA SUBRAMANIAN1,∗, P K SWAIN2,. A V DESHPANDE1 and P SATYAMURTHY2. 1Mechanical Engineering Department, Veermata Jijabai Technological Institute,.

  20. Pre-School Students' Informal Acquisitions Regarding the Concepts of Point and Straight Line

    Science.gov (United States)

    Orbay, Keziban; Develi, Mehmet Hikmet

    2015-01-01

    This study aimed to investigate the informal cognitive structures regarding "point" and "straight line"--two basic and undefined terms of geometry--in children registered in preschool--the previous step before in-class formal education process. The study was conducted with the participation of 50 children enrolled in nursery,…

  1. Straight A's: Public Education Policy and Progress. Volume 12, Number 2

    Science.gov (United States)

    Amos, Jason, Ed.

    2012-01-01

    "Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Waiving Away High School Graduation Rate Accountability?: State NCLB Waiver Proposals Threaten to Weaken…

  2. Straight A's: Public Education Policy and Progress. Volume 12, Number 7

    Science.gov (United States)

    Amos, Jason, Ed.

    2012-01-01

    "Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Problems Down the Road: House Passes Congressional Budget Resolutions, Sets Overall Spending Cap at $19 Billion Below Senate;…

  3. A Program Review of a Middle School Gay-Straight Alliance Club

    Science.gov (United States)

    Quasha, Scott; McCabe, Paul C.; Ortiz, Samuel O.

    2014-01-01

    This program review examined a middle school Gay-Straight Alliance (GSA) club within a northeastern suburban school situated in a large metropolitan area. The GSA was the first in the region to start exclusively in a standalone middle school. The review was accomplished through a staff survey comparing school climates for lesbian, gay, bisexual,…

  4. Destabilizing Anti-Gay Environments through Gay-Straight Alliances: Possibilities and Limitations through Shifting Discourses

    Science.gov (United States)

    Currie, Sean; Mayberry, Maralee; Chenneville, Tiffany

    2012-01-01

    Drawing upon research with Gay-Straight Alliance (GSA) advisors, high-school principals, and two district-level administrators, we examine the potential and limits of the safe-space discourse that encompasses the aims of GSAs. We argue that this discourse conceals heteronormative school environments, which supplies the groundwork for hostility…

  5. Perceptions of a Gay-Straight Alliance Club Ban: School Counselors and Advocacy for LGBTQQ Students

    Science.gov (United States)

    Lassiter, Pamela S.; Sifford, Amy McCarthy

    2015-01-01

    This phenomenological inquiry explored the experiences and reactions of five school counselors who worked in a school that banned a Gay-Straight Alliance club. Specifically, the authors examined how counselors' perceptions of the ban influenced their advocacy for LGBTQQ students. The results of semi-structured interviews revealed one overarching…

  6. Accounting for straight parts effects on elbow's flexibilities in a beam type finite element program

    International Nuclear Information System (INIS)

    Millard, A.

    1983-01-01

    An extension of Von Karman's theory is applied to the calculations of the flexibility factor of a pipe bend terminated by a straight part or a flange. This analysis is restricted to the linear elastic deformation behaviour under in plane bending. Analytical solutions are given for the propagation of ovalization in the elbow and in the straight part. Considering the response of the piping structures, we note that the ovalization of the piping systems are reduced significantly when the straight parts or flanges effects are included. This results are presented in terms of global as well local flexibility factors. They have been compared to numerical results obtained by shell type finite elements method. A complete piping system is analyzed, for economical reasons, with a beam type approach. Also, we show how it is possible to take into account an elbow's flexibilities the straight parts effects by means of flexibilities factors introduced in a beam type elements. We have implemented this method in the computer program TEDEL. In some specific geometrical features, we compare solutions using shell type elements and our formulation. (orig.)

  7. Effects of cavity on leakage loss in straight-through labyrinth seals

    International Nuclear Information System (INIS)

    Zhao, W; Nielsen, T K; Billdal, J T

    2010-01-01

    Labyrinth seals are widely used in rotating fluid machinery, due to its low-cost, simplicity and reliability. A straight-through labyrinth seal consists of a clearance between the stator and rotor, and sometimes cavities which are included on the stator or the rotator side. In this type of seals, making cavities are an effective way to convert turbulence kinetic energy into thermal energy by forming turbulence vortices, thereby reducing pressure difference and leakage flow. In this paper, the effect of cavities on leakage loss in straight-through labyrinth seals are studied by changing cavity dimensions such as depth and length, cavity number and cavity location. The influences of unilateral cavities and bilateral cavities on the leakage loss in straight-through labyrinth seals are also compared. The fluid flow characteristics through straight-through labyrinth seals were obtained by using viscous flow analysis along with a standard k-ωturbulence model. The cavity dimensions and cavity numbers have significant effects on the leakage as well as on the flow pattern in the seal. The bilateral cavity has better leakage performance than the unilateral cavity when cavity dimensions are identical. However, the cavity location shows no significant influences on the leakage flow.

  8. Making Schools Safe and Inclusive: Gay-Straight Alliances and School Climate in Ontario

    Science.gov (United States)

    Kitchen, Julian; Bellini, Christine

    2013-01-01

    Gay-straight alliances (GSAs) have become widespread in Ontario schools and, starting in 2012, all schools are required to permit students to form GSAs. While American research suggests that GSAs have a positive impact on school safety and inclusion, there is little research on the impact of GSAs in Canadian schools. This study, based on a survey…

  9. Duration of load behaviour of different sized straight timber beams subjected to bending in variable climate

    DEFF Research Database (Denmark)

    Hanhijärvi, A.; Galimard, P.; Hoffmeyer, Preben

    1998-01-01

    The paper is the second in a series which sums up the results of an extensive project to quantify the duration-of-load (DOL) effect on different sized timber beams in different climates. The paper deals with straight (unnotched) beams. The results of various DOL-tests of stepwise and constant...

  10. Cherry Picking: Virginity Loss Definitions Among Gay and Straight Cisgender Men.

    Science.gov (United States)

    Huang, Howard

    2017-08-03

    Virginity loss is a vital milestone in the development of one's sexual identity. Unfortunately, there is very little literature available studying virginity loss definitions among the wider straight population, and even less examining virginity loss among LGBTQ+ populations. The present study recruited 251 (45.4%) cisgender straight men and 114 (54.6%) cisgender gay men. An online, anonymous survey was administered to explore whether they considered various male-on-male (M-M) and male-on-female (M-F) sexual behaviors as constitutive of virginity loss. Results indicate that more gay men than straight considered M-M receptive anal intercourse (i.e., bottoming) and M-F penetrative anal intercourse to be constitutive of virginity loss. Results also indicate that both gay and straight men almost unanimously endorsed M-F penovaginal sex to be constitutive of virginity loss. This study is a first-step toward gaining a better understanding of LGBTQ+ virginity loss conceptualizations. Future research is strongly encouraged.

  11. Accounting for straight parts effects on elbow's flexibilities in a beam type finite element program

    International Nuclear Information System (INIS)

    Millard, A.; Vaghi, H.; Ricard, A.

    1983-08-01

    An extension of Von Karman's theory is applied to the calculations of the flexibility factor of a pipe bend terminated by a straight part or a flange. This analysis is restricted to the linear elastic deformation behaviour under in plane bending. Analytical solutions are given for the propagation of ovalization in the elbow and in the straight part. Considering the response of the piping structures, we note that the ovalization of the piping systems are reduced significantly when the straight parts or flanges effects are included. The results are presented in terms of global as well local flexibility factors. They have been compared to numerical results obtained by shell type finite element method. A complete piping system is analyzed, for economical reasons, with a beam type approach. Also, we show how it is possible to take into account on elbow's flexibilities the straight parts effects by means of flexibilities factors introduced in a beam type element. We have implemented this method in the computer program TEDEL. In some specific geometrical features, we compare solutions using shell type elements and our formulation

  12. Straight A's: Public Education Policy and Progress. Volume 12, Number 9

    Science.gov (United States)

    Amos, Jason, Ed.

    2012-01-01

    "Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) You Take the High Road and I'll Take the Low Road: As Appropriations Process Begins, Different Spending Approaches Likely to…

  13. Gay-Straight Alliances in the Battle for Rights: A Tipping Point for Progress over Prohibition

    Science.gov (United States)

    Sinclair, James; Reece, Brian J.

    2016-01-01

    This is a brief essay on the oppressive natures of school and the rights of students to arm themselves with the creation of Gay-Straight Alliances (GSAs). Students who identify as LGBTQ are at higher risk for victimization, among other negative outcomes. For those who identify as LGBTQ, GSAs are often a safe-haven from the heteronormative…

  14. Comparison of coupled mode theory and FDTD simulations of coupling between bent and straight optical waveguides

    NARCIS (Netherlands)

    Bertolotti, M.; Symes, W.W.; Stoffer, Remco; Hiremath, K.R.; Driessen, A.; Michelotti, F; Hammer, Manfred

    Analysis of integrated optical cylindrical microresonators involves the coupling between a straight waveguide and a bent waveguide. Our (2D) variant of coupled mode theory is based on analytically represented mode profiles. With the bend modes expressed in Cartesian coordinates, coupled mode

  15. Design and Validation of a Straight-Copy Typewriting Prognostic Test Using Kinesthetic Sensitivity.

    Science.gov (United States)

    Olson, Norma Jean

    1979-01-01

    Describes the development and application of a kinesthetic sensitivity test to determine whether it is a valid and reliable measure of straight-copy typing speed and accuracy. The author states that this kinesthetic sensitivity instrument may be used as a prognostic aptitude test and recommends administration methods. (MF)

  16. Trends in Canadian Newspaper Coverage of Gay-Straight Alliances, 2000-2009

    Science.gov (United States)

    Herriot, Lindsay

    2011-01-01

    Gay-straight alliances (GSAs) in Canadian public schools have gained considerable attention from print media since reports first surfaced in the year 2000. This study tracked and analyzed Canadian newspaper reporting about GSA creation. It summarized the shift in public opinion toward lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth…

  17. Gender, health behavior, and intimate relationships: lesbian, gay, and straight contexts.

    Science.gov (United States)

    Reczek, Corinne; Umberson, Debra

    2012-06-01

    Many studies focus on health behavior within the context of intimate ties. However, this literature is limited by reliance on gender socialization theory and a focus on straight (i.e., heterosexual) marriage. We extend this work with an analysis of relationship dynamics around health behavior in 20 long-term straight marriages as well as 15 gay and 15 lesbian long-term cohabiting partnerships in the United States (N = 100 individual in-depth interviews). We develop the concept of "health behavior work" to align activities done to promote health behavior with theories on unpaid work in the home. Respondents in all couple types describe specialized health behavior work, wherein one partner works to shape the other partner's health behavior. In straight couples, women perform the bulk of specialized health behavior work. Most gay and lesbian respondents-but few straight respondents--also describe cooperative health behavior work, wherein partners mutually influence one another's health behaviors. Findings suggest that the gendered relational context of an intimate partnership shapes the dynamics of and explanations for health behavior work. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Optimizing the injection straight of PEP II asymmetric B Factory at SLAC

    International Nuclear Information System (INIS)

    Bulos, F.; Bloom, E.; Davies-White, W.; Donald, M.; Fairfield, K.; Fieguth, T.; Godfrey, G.; Holtzapple, R.; Hutton, A.; Loew, G.; Miller, R.; Sukiennicki, B.; Wen, H.; Ronan, M.

    1992-04-01

    The asymmetric energy PEP II B Factory proposed as an upgrade of PEP at the Stanford Linear Accelerator Center requires both a powerful low emittance source of e - e + and a very reliable and efficient injection system. The SLC linac fulfills the source requirement very well. We describe here the optimization of the optics of the injection straight to insure reliable and efficient injection

  19. Straight vegetable oils usage in a compression ignition engine - A review

    Energy Technology Data Exchange (ETDEWEB)

    Misra, R.D.; Murthy, M.S. [Mechanical Engineering Department, National Institute of Technology, Silchar 788010, Assam (India)

    2010-12-15

    The ever increasing fossil fuel usage and cost, environmental concern has forced the world to look for alternatives. Straight vegetable oils in compression ignition engine are a ready solution available, however, with certain limitations and with some advantages as reported by many researchers. A comprehensive and critical review is presented specifically pertaining to straight vegetable oils usage in diesel engine. A detailed record of historical events described. Research carried out specifically under Indian conditions and international research work on the usage of straight vegetable oils in the diesel engine is separately reviewed. Many researchers have reported that straight vegetable oils in small percentage blends with diesel when used lower capacity diesel engines have shown great promise with regards to the thermal performance as well exhaust emissions. This has been explained in detail. Finally based on the review of international as well as Indian research a SWOT analysis is carried out. The review concludes that there is still scope for research in this area. (author)

  20. Straight chiropractic philosophy as a barrier to Medicare compliance: a discussion of 5 incongruent issues.

    Science.gov (United States)

    Seaman, David R; Soltys, Jonathan R

    2013-12-01

    The purpose of this commentary is to discuss potential 5 factors within straight chiropractic philosophy and practice that may prevent Medicare compliance. The national Medicare Benefit Policy Manual and the Florida Local Coverage Determination were reviewed to identify documentation and conceptual issues regarding chiropractic practice. Five Medicare positions were contrasted with tenets of straight chiropractic philosophy. Based on Medicare's documentation requirements, Medicare defines subluxation and chiropractic practice from the perspective of treating spinal pain and related functional disability. In contrast, traditional straight chiropractic philosophy is not based on the treatment of spinal pain and disability or other symptomatic presentations. In this context, 5 potential areas of conflict are discussed. The Medicare version of chiropractic practice is not consistent with traditional straight chiropractic philosophy, which may play a role in preventing Medicare compliance. The chiropractic profession may need to consider the fashion in which "philosophy" as it relates to technique and practice is presented to students and doctors to facilitate compliance with the documentation requirements of Medicare.

  1. Straight A's: Public Education Policy and Progress. Volume 6, Number 2

    Science.gov (United States)

    Amos, Jason, Ed.

    2006-01-01

    "Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) State of American Business: U.S. Chamber of Commerce Says U.S. Could Face a "Severe Worker Shortage" Unless…

  2. Optimizing the injection straight of PEP II asymmetric B factory at SLAC

    International Nuclear Information System (INIS)

    Bulos, F.; Bloom, E.; Davies-White, W.; Donald, M.; Fairfield, K.; Fieguth, T.; Godfrey, G.; Holtzapple, R.; Hutton, A.; Loew, G.; Miller, R.; Sukiennicki, B.; Wen, H.

    1992-01-01

    The asymmetric energy PEP II B Factory proposed as an upgrade of PEP at the Stanford Linear Accelerator Center requires both a powerful low emittance source of e - e + and a very reliable and efficient injection system. The SLC linac fulfills the source requirement very well. We describe here the optimization of the optics of the injection straight to insure reliable and efficient injection

  3. Offsetting Risks: High School Gay-Straight Alliances and Lesbian, Gay, Bisexual, and Transgender (LGBT) Youth

    Science.gov (United States)

    Heck, Nicholas C.; Flentje, Annesa; Cochran, Bryan N.

    2011-01-01

    Lesbian, gay, bisexual, and transgender (LGBT) youth are at risk for engaging in negative health behaviors and for experiencing at-school victimization. Specific benefits of attending a high school with a gay-straight alliance (GSA), including lower levels of suicidality, have been published; however, it is unclear whether GSAs are related to…

  4. Demographic Trends and Advocacy Experiences of Gay-Straight Alliance Advisors

    Science.gov (United States)

    Graybill, Emily C.; Varjas, Kris; Meyers, Joel; Dever, Bridget V.; Greenberg, Daphne; Roach, Andrew T.; Morillas, Catalina

    2015-01-01

    Using an ecological model, the individual-, school-, and sociocultural-level characteristics that affect gay-straight alliance (GSA) advisors were examined in the current study. The formation of GSAs has been one way that schools have sought to improve the school climate for lesbian, gay, bisexual, and transgender (LGBT) youth. Limited information…

  5. Use of Straight –Run Gasoline (Srg) as A Leaching Solvent for Oil ...

    African Journals Online (AJOL)

    A study was conducted on the use of straight-run gasoline (SRG) as an extraction solvent for the leaching of palm kernel to produce palm kernel oil (PKO). SRG is an intermediate product fraction in the second fraction of crude petroleum oil fractionation that has not undergone any purification process. It is intended as a ...

  6. Charged Particle Dynamics in the Magnetic Field of a Long Straight Current-Carrying Wire

    Science.gov (United States)

    Prentice, A.; Fatuzzo, M.; Toepker, T.

    2015-01-01

    By describing the motion of a charged particle in the well-known nonuniform field of a current-carrying long straight wire, a variety of teaching/learning opportunities are described: 1) Brief review of a standard problem; 2) Vector analysis; 3) Dimensionless variables; 4) Coupled differential equations; 5) Numerical solutions.

  7. Morbidity Following Coloanal Anastomosis: A Comparison of Colonic J-Pouch vs Straight Anastomosis.

    Science.gov (United States)

    Brown, Shaun; Margolin, David A; Altom, Laura K; Green, Heather; Beck, David E; Kann, Brian R; Whitlow, Charles B; Vargas, Herschel David

    2018-02-01

    Low rectal tumors are often treated with sphincter-preserving resection followed by coloanal anastomosis. The purpose of this study was to compare the short-term complications following straight coloanal anastomosis vs colonic J-pouch anal anastomosis. Patients were identified who underwent proctectomy for rectal neoplasia followed by coloanal anastomosis in the 2008 to 2013 American College of Surgeons National Surgical Quality Improvement Program database. Demographic characteristics and 30-day postoperative complications were compared between groups. A national sample was extracted from the American College of Surgeons National Surgical Quality Improvement Project database. Inpatients following proctectomy and coloanal anastomosis for rectal cancer were selected. Demographic characteristics and 30-day postoperative complications were compared between the 2 groups. One thousand three hundred seventy patients were included, 624 in the straight anastomosis group and 746 in the colonic J-pouch group. Preoperative characteristics were similar between groups, with the exception of preoperative radiation therapy (straight anastomosis 35% vs colonic J-pouch 48%, p = 0.0004). Univariate analysis demonstrated that deep surgical site infection (3.7% vs 1.4%, p = 0.01), septic shock (2.25% vs 0.8%, p = 0.04), and return to the operating room (8.8% vs 5.0%, p = 0.0006) were more frequent in the straight anastomosis group vs the colonic J-pouch group. Major complications were also higher (23% vs 14%, p = 0.0001) and length of stay was longer in the straight anastomosis group vs the colonic J-pouch group (8.9 days vs 8.1 days, p = 0.02). After adjusting for covariates, major complications were less following colonic J-pouch vs straight anastomosis (OR, 0.57; CI, 0.38-0.84; p = 0.005). Subgroup analysis of patients who received preoperative radiation therapy demonstrated no difference in major complications between groups. This study had those limitations inherent to a

  8. Straight proximal humeral nails are surrounded by more bone stock in comparison to bent nails in an experimental cadaveric study.

    Science.gov (United States)

    Günther, Christian Max; Müller, Peter Ernst; Mutschler, Wolf; Sprecher, Christoph Martin; Milz, Stefan; Braunstein, Volker

    2014-01-01

    In the management of proximal humeral fractures intramedullary implants with bent and straight shape of the proximal part of nail are available. Based on data from previous studies on bone distribution in the humeral head, we hypothesized, that higher densities might exist in the bone stock surrounding straight nails in comparison to their angulated counterparts. With a known positive correlation between bone density and mechanical stability, this could indicate potentially higher rigidity of osteosyntheses done with straight implants. We performed high resolution peripheral quantitative computed tomographies of the potential straight and bent implant bearing regions of 27 cadaveric proximal humeri. The acquired data were analyzed for differences between straight and bent Volumes of Interest as well as intra- and interindividual bone stock distribution. For both straight and bent volumes of interest a considerably declining bone mineral density was found in craniocaudal direction. Mean densities of bent volumes were significantly lower in comparison to their corresponding straight counterparts (p straight shaped implants can be assumed. Since we found a rapid decrease of bone density in cranio-caudal direction, intramedullary implants should be anchored as proximally in the subcortical area as possible to minimize the risk of displacement or cutout. The high correlation between the Volumes of Interest of the corresponding right and left sides could aid in preoperative planning when considering an intra- or extramedullary approach.

  9. NMR characterization of weak interactions between RhoGDI2 and fragment screening hits.

    Science.gov (United States)

    Liu, Jiuyang; Gao, Jia; Li, Fudong; Ma, Rongsheng; Wei, Qingtao; Wang, Aidong; Wu, Jihui; Ruan, Ke

    2017-01-01

    The delineation of intrinsically weak interactions between novel targets and fragment screening hits has long limited the pace of hit-to-lead evolution. Rho guanine-nucleotide dissociation inhibitor 2 (RhoGDI2) is a novel target that lacks any chemical probes for the treatment of tumor metastasis. Protein-observed and ligand-observed NMR spectroscopy was used to characterize the weak interactions between RhoGDI2 and fragment screening hits. We identified three hits of RhoGDI2 using streamlined NMR fragment-based screening. The binding site residues were assigned using non-uniformly sampled C α - and H α -based three dimensional NMR spectra. The molecular docking to the proposed geranylgeranyl binding pocket of RhoGDI2 was guided by NMR restraints of chemical shift perturbations and ligand-observed transferred paramagnetic relaxation enhancement. We further validated the weak RhoGDI2-hit interactions using mutagenesis and structure-affinity analysis. Weak interactions between RhoGDI2 and fragment screening hits were delineated using an integrated NMR approach. Binders to RhoGDI2 as a potential anti-cancer target have been first reported, and their weak interactions were depicted using NMR spectroscopy. Our work highlights the powerfulness and the versatility of the integrative NMR techniques to provide valuable structural insight into the intrinsically weak interactions between RhoGDI2 and the fragment screening hits, which could hardly be conceived using other biochemical techniques. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Influence of The Difference of Perception and Kinesthetic Exercise Methods Against Precision Hit The Ball Softball

    Directory of Open Access Journals (Sweden)

    Fajar Rokhayah

    2017-06-01

    Full Text Available The purpose of this study was to determine: 1 The difference between the effects of training methods and the gradual striking distance striking distance remains as to the accuracy of hitting the ball Softball. 2 The difference in accuracy influence Softball hitting the ball between the athletes who have a good kinesthetic perception, kinesthetic perception was, and kinesthetic perception less. 3 The effect of interaction between training methods with kinesthetic perception as to the accuracy of hitting the ball Softball. This study used an experimental method with 2x3 factorial design. The results of this study were: 1 There is a significant difference between the gradual striking distance training methods and training methods remain striking distance of the ability to hit a softball with the result of the acquisition value p-value = 0.027 smaller than 0.05. 2 There is a significant difference between athletes who have a kinesthetic perception of good, moderate, lacking the ability to hit a softball with the result of the acquisition value p-value = 0.000, which is smaller than 0.05. 3 There is an interaction between striking distance training methods and kinesthetic perception of the ability to hit a softball with the result of the acquisition value p-value = 0.000, which is smaller than 0.05 The conclusion of this study were: 1 Gradually striking distance training methods have a better effect than the fixed striking distance training methods. 2 Athletes who have less kinesthetic perception has better results than the athletes who have good kinesthetic perception and being. 3 There is an interaction between striking distance training methods and kinesthetic perception of the ability to hit a softball.

  11. The measurements of water flow rates in the straight microchannel based on the scanning micro-PIV technique

    Science.gov (United States)

    Wang, H. L.; Han, W.; Xu, M.

    2011-12-01

    Measurement of the water flow rate in microchannel has been one of the hottest points in the applications of microfluidics, medical, biological, chemical analyses and so on. In this study, the scanning microscale particle image velocimetry (scanning micro-PIV) technique is used for the measurements of water flow rates in a straight microchannel of 200μm width and 60μm depth under the standard flow rates ranging from 2.481μL/min to 8.269μL/min. The main effort of this measurement technique is to obtain three-dimensional velocity distribution on the cross sections of microchannel by measuring velocities of the different fluid layers along the out-of-plane direction in the microchannel, so the water flow rates can be evaluated from the discrete surface integral of velocities on the cross section. At the same time, the three-dimensional velocity fields in the measured microchannel are simulated numerically using the FLUENT software in order to verify the velocity accuracy of measurement results. The results show that the experimental values of flow rates are well consistent to the standard flow rates input by the syringe pump and the compared results between numerical simulation and experiment are consistent fundamentally. This study indicates that the micro-flow rate evaluated from three-dimensional velocity by the scanning micro-PIV technique is a promising method for the micro-flow rate research.

  12. Distorted eikonal cross sections: A time-dependent view

    International Nuclear Information System (INIS)

    Turner, R.E.

    1982-01-01

    For Hamiltonians with two potentials, differential cross sections are written as time-correlation functions of reference and distorted transition operators. Distorted eikonal differential cross sections are defined in terms of straight-line and reference classical trajectories. Both elastic and inelastic results are obtained. Expressions for the inelastic cross sections are presented in terms of time-ordered cosine and sine memory functions through the use of the Zwanzig-Feshbach projection-operator method

  13. Computational Stud of Flow in Curved Pipes with Circular-Section

    OpenAIRE

    Shirayama, Susumu; Kawamura, Tetsuya; Kuwahara, Kunio; 白山, 晋; 河村, 哲也; 桑原, 邦郎

    1985-01-01

    By solving the incompressible Navier-Stokes equations the flow field is calculated in a circular-sectioned pipe with a straight inlet or gradually enlarged inlet in the higher Dean number. With the straight inlet, a secondary flow of cross-stream planes was obtained and with the higher Dean number some different flow patterns were obtained. With the gradually enlarged inlet, the difference of flow patterns corresponding to Reynolds number could be simulated.

  14. Gorlin syndrome with an ovarian leiomyoma associated with a PTCH1 second hit.

    Science.gov (United States)

    Akizawa, Yoshika; Miyashita, Toshiyuki; Sasaki, Ryo; Nagata, Reiko; Aoki, Ryoko; Ishitani, Ken; Nagashima, Yoji; Matsui, Hideo; Saito, Kayoko

    2016-04-01

    We describe a Gorlin syndrome (GS) case with two different second hit mutations of PTCH1, one in a keratocystic odontogenic tumor (KCOT) and the other in an ovarian leiomyoma. GS is a rare genetic condition manifesting as multiple basal cell nevi associated with other features such as medulloblastomas, skeletal abnormalities, and ovarian fibromas. A 21-year-old Japanese woman with a history of two KCOTs was diagnosed with GS according to clinical criteria. A PTCH1 mutation, c.1427del T, was detected in peripheral blood. A novel PTCH1 mutation, c.264_265insAATA, had been found in the maxillary KCOT as a second hit mutation. More recently, the ovarian tumor was detected during a gynecological examination. Laparoscopic adnexectomy was performed, and the pathological diagnosis of the ovarian tumor was leiomyoma. Interestingly, another novel mutation, loss of heterozygosity spanning from 9q22.32 to 9q31.2, including PTCH1 and 89 other genes, was detected in this ovarian tumor, providing evidence of a second hit mutation. This is the first report describing a GS-associated ovarian tumor carrying a second hit in the PTCH1 region. We anticipate that accumulation of more cases will clarify the importance of second hit mutations in ovarian tumor formation in GS. © 2016 Wiley Periodicals, Inc.

  15. Progress on FIR interferometry and Thomson Scattering measurements on HIT-SI3

    Science.gov (United States)

    Everson, Christopher; Jarboe, Thomas; Morgan, Kyle

    2017-10-01

    Spatially resolved measurements of the electron temperature (Te) and density (ne) will be fundamental in assessing the degree to which HIT-SI3 demonstrates closed magnetic flux and energy confinement. Further, electron temperature measurements have not yet been made on an inductively-driven spheromak. Far infrared (FIR) interferometer and Thomson Scattering (TS) systems have been installed on the HIT-SI3 spheromak. The TS system currently implemented on HIT-SI3 was originally designed for other magnetic confinement experiments, and progress continues toward modifying and optimizing for HIT-SI3 plasmas. Initial results suggest that the electron temperature is of order 10 eV. Plans to modify the TS system to provide more sensitivity and accuracy at low temperatures are presented. The line-integrated ne is measured on one chord by the FIR interferometer, with densities near 5x1019 m-3. Four cylindrical volumes have been added to the HIT-SI3 apparatus to enhance passive pumping. It is hoped that this will allow for more control of the density during the 2 ms discharges. Density measurements from before and after the installation of the passive pumping volumes are presented for comparison.

  16. Laboratory tests for identification or exclusion of heparin induced thrombocytopenia: HIT or miss?

    Science.gov (United States)

    Favaloro, Emmanuel J

    2018-02-01

    Heparin induced thrombocytopenia (HIT) is a potentially fatal condition that arises subsequent to formation of antibodies against complexes containing heparin, usually platelet-factor 4-heparin ("anti-PF4-heparin"). Assessment for HIT involves both clinical evaluation and, if indicated, laboratory testing for confirmation or exclusion, typically using an initial immunological assay ("screening"), and only if positive, a secondary functional assay for confirmation. Many different immunological and functional assays have been developed. The most common contemporary immunological assays comprise enzyme-linked immunosorbent assay [ELISA], chemiluminescence, lateral flow, and particle gel techniques. The most common functional assays measure platelet aggregation or platelet activation events (e.g., serotonin release assay; heparin-induced platelet activation (HIPA); flow cytometry). All assays have some sensitivity and specificity to HIT antibodies, but differ in terms of relative sensitivity and specificity for pathological HIT, as well as false negative and false positive error rate. This brief article overviews the different available laboratory methods, as well as providing a suggested approach to diagnosis or exclusion of HIT. © 2017 Wiley Periodicals, Inc.

  17. Anticipating mismatches of HIT investments: Developing a viability-fit model for e-health services.

    Science.gov (United States)

    Mettler, Tobias

    2016-01-01

    Albeit massive investments in the recent years, the impact of health information technology (HIT) has been controversial and strongly disputed by both research and practice. While many studies are concerned with the development of new or the refinement of existing measurement models for assessing the impact of HIT adoption (ex post), this study presents an initial attempt to better understand the factors affecting viability and fit of HIT and thereby underscores the importance of also having instruments for managing expectations (ex ante). We extend prior research by undertaking a more granular investigation into the theoretical assumptions of viability and fit constructs. In doing so, we use a mixed-methods approach, conducting qualitative focus group discussions and a quantitative field study to improve and validate a viability-fit measurement instrument. Our findings suggest two issues for research and practice. First, the results indicate that different stakeholders perceive HIT viability and fit of the same e-health services very unequally. Second, the analysis also demonstrates that there can be a great discrepancy between the organizational viability and individual fit of a particular e-health service. The findings of this study have a number of important implications such as for health policy making, HIT portfolios, and stakeholder communication. Copyright © 2015. Published by Elsevier Ireland Ltd.

  18. Comparison of conventional straight and swan-neck straight catheters inserted by percutaneous method for continuous ambulatory peritoneal dialysis: a single-center study.

    Science.gov (United States)

    Singh, Shivendra; Prakash, Jai; Singh, R G; Dole, P K; Pant, Pragya

    2015-10-01

    To evaluate the incidence of mechanical and infectious complications of conventional straight catheter (SC) versus swan-neck straight catheter (SNSC) implanted by percutaneous method. We retrospectively analyzed 45 catheter insertions being done by percutaneous method from January 1, 2011, to May 31, 2014. SC was inserted in 24 patients, and SNSC was inserted in 21 patients. Baseline characteristics for the two groups were similar with respect to age, sex and diabetic nephropathy as the cause for end-stage renal disease. Incidence of mechanical and infectious complications in SNSC group was found to be low as compared to the SC group and was statistically significant (1 in 11.6 patient months vs. 1 in 14.4 patient months, p = 0.02). Catheter migration was found to be the most common mechanical complication (20 %), and peritonitis was found to be the most common infectious complication in conventional SC group (27 episodes in 420 patient months vs. 11 episodes in 333 patient months, p = 0.03). The incidence of exit site and tunnel infection rates revealed no difference between the groups. SNSC insertion by percutaneous method is associated with low mechanical and infectious complications.

  19. Comparison of Axillary Loop and Straight Grafts Patency and Their Complications for Hemodialylis Access

    Directory of Open Access Journals (Sweden)

    J KHoshnevis

    2011-08-01

    Full Text Available Introduction & Objective: Dialysis vascular access complications are important causes of morbidity in chronic hemodialysis patients. The aim of the present study was a comparison of auxillary loop and atraight grafts patency and its complications for hemodialysis access. Materials & Methods: In this cohort study conducted at Shahid Beheshti Medical University, 58 patients who underwent placement of loop or straight access grafts were included in the study. Demographics, primary and secondary patency rates and complications like thrombosis, infection, bleeding, steal syndrome and other complications were compared in these two groups. The collected data was analyzed by the SPSS statistical software using the chi-square test, t-test, and logistic regression. Results: Thrombosis rates were 51.1% and 53.8% in straight and loop groups respectively (P=0.862, steal syndrome rates were 2.2% and 7.7% in straight and loop groups respectively (P=0.341, psudoanevrism were 11.1% and 23.1% in straight and loop groups respectively (P=0.270, bleeding rates were 4.4% and 0% in straight and loop groups respectively (P=0.439, infection rate were 8.9% and 7.7% in straight and loop groups respectively (P=0.892, and primary patency rate after 1 month were 88.9% and 92.3% respectively (P=0.721, and primary patency rate after 24 month were 31% and 55.5% respectively (P=0.058. Secondary patency rate after 3 month were 75.6% and 92.3% respectively (P=0.189, and secondary patency rate after 24 month were 37.9% and 66.7% respectively (P=0.044. Conclusion: PTFE vascular graft seems to be an appropriate vascular access and is a promising alternative when upper extremity arteriovenous fistulas cannot be constructed. Additionally, there was no significant different between two groups for complications and early patency, but late patency was better in loop group. More study is necessary for final judgment.

  20. Polygonal Area of Prosthesis Support with Straight and Tilted Dental Implants in Edentulous Maxillae.

    Science.gov (United States)

    Wentaschek, Stefan; Lehmann, Karl Martin; Scheller, Herbert; Weibrich, Gernot; Behneke, Nikolaus

    2016-01-01

    The aim of this in vitro study was to assess the increase in the polygonal area of implant-retained prosthesis supports in edentulous maxillae with the use of tilted distal implants compared with the use of straight distal implants, using a variety of implant lengths. A total of 25 DICOM datasets of atrophic edentulous maxillae were provided. Bone augmentations in the molar region had to be avoided. Two straight reference implants were virtually inserted in the anterior region. Two additional implants were placed far distally on both sides (4 groups: [1] straight, 12-mm length; [2] straight, 10 mm; [3] straight, 8 mm; [4] tilted, 12-16 mm). The resulting implant-supported polygon was measured for each of the 4 groups using three-dimensional planning software. The mean sagittal depth of the supported polygon in Group 1 was 9.9 mm (standard deviation [SD] 4.4) on the right and 10.2 mm (SD 4.4) on the left, and it was 33.7 mm (SD 5.8) in width. For Group 2, the mean sagittal depth was 11.5 mm (SD 5.0) on the right and 11.9 mm (SD 4.7) on the left, and the width was 35.2 mm (SD 5.6). The measurements for Group 3 were 13.8 mm (SD 4.9) deep on the right, 13.8 mm (SD 5.1) deep on the left, and 37.0 mm (SD 5.4) in width. For Group 4, the depth was 15.8 mm (SD 4.9) on the right and 16.4 mm (SD 5.8) on the left, and the width was 39.0 mm (SD 5.1). The area of implant-retained prosthesis support can be enlarged by the use of tilted implants (12 to 16 mm in length, 42 to 45 degrees) compared to the use of straight 8-mm implants (resulting increase: about 15%).

  1. Axial velocity profiles and secondary flows of developing laminar flows in a straight connected exit region of a 180 .deg. square curved duct

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Hyun Chull; Lee, Heang Nam; Park, Gil Moon [Chosun Univ., Gwangju (Korea, Republic of)

    2005-10-01

    In the present study, characteristics of steady state laminar flows of a straight duct connected to a 180 .deg. curved duct were examined in the entrance region through experimental and numerical analyses. For the analysis, the governing equations of laminar flows in the Cartesian coordinate system were applied. Flow characteristics such as velocity profiles and secondary flows were investigated numerically and experimentally in a square cross-sectional straight duct by the PIV system and a CFD code (STARCD). For the PIV measurement, smoke particles produced from mosquito coils. The experimental data were obtained at 9 points dividing the test sections by 400 mm. Experimental and numerical results can be summarized as follows. 1) Reynolds number, Re was increased, dimensionless velocity profiles at the outer wall were increased due to the effect of the centrifugal force and secondary flows. 2) The intensity of a secondary flow became stronger at the inner wall rather than the outer wall regardless of Reynolds number. Especially, fluid dynamic phenomenon called conner impact were observed at dimensionless axial position, x/D{sub h}=50.

  2. Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.

    Science.gov (United States)

    Sanders, John M; Beshore, Douglas C; Culberson, J Christopher; Fells, James I; Imbriglio, Jason E; Gunaydin, Hakan; Haidle, Andrew M; Labroli, Marc; Mattioni, Brian E; Sciammetta, Nunzio; Shipe, William D; Sheridan, Robert P; Suen, Linda M; Verras, Andreas; Walji, Abbas; Joshi, Elizabeth M; Bueters, Tjerk

    2017-08-24

    High-throughput screening (HTS) has enabled millions of compounds to be assessed for biological activity, but challenges remain in the prioritization of hit series. While biological, absorption, distribution, metabolism, excretion, and toxicity (ADMET), purity, and structural data are routinely used to select chemical matter for further follow-up, the scarcity of historical ADMET data for screening hits limits our understanding of early hit compounds. Herein, we describe a process that utilizes a battery of in-house quantitative structure-activity relationship (QSAR) models to generate in silico ADMET profiles for hit series to enable more complete characterizations of HTS chemical matter. These profiles allow teams to quickly assess hit series for desirable ADMET properties or suspected liabilities that may require significant optimization. Accordingly, these in silico data can direct ADMET experimentation and profoundly impact the progression of hit series. Several prospective examples are presented to substantiate the value of this approach.

  3. Acceleration and support post deformation measurements during surface and tunnel transport of a LHC Short Straight Section

    CERN Document Server

    Capatina, O; CERN. Geneva. TS Department

    2004-01-01

    This technical note is a complement to the technical note [1]. The former technical note dealt with the experimental modal analysis and the road transport with transport restraints and special suspension. The present note describes the measured accelerations and support post deformations during road transport at reduced speed without end restraints or special suspension. This note also reports the accelerations and support post deformations during handling and tunnel transport with the dedicated tunnel vehicle. The measured accelerations are compared with the specified acceleration limits.

  4. Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

    Science.gov (United States)

    Xie, Yiyue; Dahlin, Jayme L; Oakley, Aaron J; Casarotto, Marco G; Board, Philip G; Baell, Jonathan B

    2018-05-10

    Early stage drug discovery reporting on relatively new or difficult targets is often associated with insufficient hit triage. Literature reviews of such targets seldom delve into the detail required to critically analyze the associated screening hits reported. Here we take the enzyme glutathione transferase omega-1 (GSTO1-1) as an example of a relatively difficult target and review the associated literature involving small-molecule inhibitors. As part of this process we deliberately pay closer-than-usual attention to assay interference and hit quality aspects. We believe this Perspective will be a useful guide for future development of GSTO1-1 inhibitors, as well serving as a template for future review formats of new or difficult targets.

  5. A New Track Reconstruction Algorithm suitable for Parallel Processing based on Hit Triplets and Broken Lines

    Directory of Open Access Journals (Sweden)

    Schöning André

    2016-01-01

    Full Text Available Track reconstruction in high track multiplicity environments at current and future high rate particle physics experiments is a big challenge and very time consuming. The search for track seeds and the fitting of track candidates are usually the most time consuming steps in the track reconstruction. Here, a new and fast track reconstruction method based on hit triplets is proposed which exploits a three-dimensional fit model including multiple scattering and hit uncertainties from the very start, including the search for track seeds. The hit triplet based reconstruction method assumes a homogeneous magnetic field which allows to give an analytical solutions for the triplet fit result. This method is highly parallelizable, needs fewer operations than other standard track reconstruction methods and is therefore ideal for the implementation on parallel computing architectures. The proposed track reconstruction algorithm has been studied in the context of the Mu3e-experiment and a typical LHC experiment.

  6. An automated single ion hit at JAERI heavy ion microbeam to observe individual radiation damage

    International Nuclear Information System (INIS)

    Kamiya, Tomihiro; Sakai, Takuro; Naitoh, Yutaka; Hamano, Tsuyoshi; Hirao, Toshio

    1999-01-01

    Microbeam scanning and a single ion hit technique have been combined to establish an automated beam positioning and single ion hit system at the JAERI Takasaki heavy ion microbeam system. Single ion irradiation on preset points of a sample in various patterns can be performed automatically in a short period. The reliability of the system was demonstrated using CR-39 nuclear track detectors. Single ion hit patterns were achieved with a positioning accuracy of 2 μm or less. In measurement of single event transient current using this system, the reduction of the pulse height by accumulation of radiation damages was observed by single ion injection to the same local areas. This technique showed a possibility to get some quantitative information about the lateral displacement of an individual radiation effect in silicon PIN photodiodes. This paper will give details of the irradiation system and present results from several experiments

  7. Measurements and Simulations on the Mechanisms of Efficiency Losses in HIT Solar Cells

    Directory of Open Access Journals (Sweden)

    Silvio Pierro

    2015-01-01

    Full Text Available We study the electrical and the optical behavior of HIT solar cell by means of measurements and optoelectrical simulations by TCAD simulations. We compare the HIT solar cell with a conventional crystalline silicon solar cell to identify the strengths and weaknesses of the HIT technology. Results highlight different mechanisms of electrical and optical efficiency losses caused by the presence of the amorphous silicon layer. The higher resistivity of the a-Si layers implies a smaller distance between the metal lines that causes a higher shadowing. The worst optical coupling between the amorphous silicon and the antireflective coating implies a slight increase of reflectivity around the 600 nm wavelength.

  8. Steering straight

    Energy Technology Data Exchange (ETDEWEB)

    Louie, Jacqueline

    2011-12-15

    Baker Hughes Inc. has developed a deep azimuthal resistivity measurement tool for subsurface navigation when drilling oil and gas wells. This tool, named AziTrak, has measurement-while-drilling and logging-while-drilling capabilities and data are sent in real time to the surface via mud pulse or wired pipe telemetry. This technology helps the operator detect and visualize bed boundaries in real time, thanks to 3D imagery and a 360 degree view of the subsurface. The AziTrak system makes it possible to steer proactively and to stay within the pay zone at all times to maximize production; the tool had excellent results in field applications. Although this tool is 5 times more expensive than conventional technologies, its use results in a more economic wellbore thanks to its great utility. If the operator puts a high degree of involvement into it, the AziTrak deep azimuthal resistivity measurement tool will allow him to stay in the pay zone at all times.

  9. Straight choices

    CERN Multimedia

    2001-01-01

    The HEP community is already discussing what kind of projects will take over from the Tevatron and LHC in around 2020. There is general agreement that the next collider must be a truly international collaboration, there is much less agreement on where it will be built. The most important consideration though is that the best possible machine is built Somewhere in the world (1 page editorial).

  10. Thinking straight

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Two thousand five hundred linear accelerators are now estimated to be in use throughout the world. Of these a negligible number are on particle physics machines; yet they have all stemmed from the technology developed to do particle physics. This figure was quoted at the 1986 Linear Accelerator Conference which drew 300 linac specialists to Stanford in June for a meeting excellently organized under Greg Loew

  11. Unzip instabilities: Straight to oscillatory transitions in the cutting of thin polymer sheets

    Science.gov (United States)

    Reis, P. M.; Kumar, A.; Shattuck, M. D.; Roman, B.

    2008-06-01

    We report an experimental investigation of the cutting of a thin brittle polymer sheet with a blunt tool. It was recently shown that the fracture path becomes oscillatory when the tool is much wider than the sheet thickness. Here we uncover two novel transitions from straight to oscillatory fracture by varying either the tilt angle of the tool or the speed of cutting, respectively. We denote these by angle and speed unzip instabilities and analyze them by quantifying both the dynamics of the crack tip and the final shapes of the fracture paths. Moreover, for the speed unzip instability, the straight crack lip obtained at low speeds exhibits out-of-plane buckling undulations (as opposed to being flat above the instability threshold) suggesting a transition from ductile to brittle fracture.

  12. Transitions in pedestrian fundamental diagrams of straight corridors and T-junctions

    International Nuclear Information System (INIS)

    Zhang, J; Klingsch, W; Schadschneider, A; Seyfried, A

    2011-01-01

    Many observations of pedestrian dynamics, including various self-organization phenomena, have been reproduced successfully by different models. But the empirical databases for quantitative calibration are still insufficient, e.g. the fundamental diagram as one of the most important relationships displays non-negligible differences among various studies. To improve this situation, experiments in straight corridors and T-junctions are performed. Four different measurement methods are defined to study their effects on the fundamental diagram. It is shown that they have minor influences for ρ −2 but only the Voronoi method is able to resolve the fine structure of the fundamental diagram. This enhanced measurement method permits us to observe the occurrence of a boundary-induced phase transition. For corridors of different widths we found that the specific flow concept works well for ρ −2 . Moreover, we illustrate the discrepancies between the fundamental diagrams of a T-junction and a straight corridor

  13. Implicit Preferences for Straight People over Lesbian Women and Gay Men Weakened from 2006 to 2013

    Directory of Open Access Journals (Sweden)

    Erin C Westgate

    2015-07-01

    Full Text Available Legal rights and cultural attitudes towards lesbian women and gay men have shifted rapidly in the early 21st century. Using 683,976 visitors to Project Implicit from February 2006 to August 2013, we investigated whether shifts were also observable in implicit evaluations that occur outside of conscious awareness or control. Similar to public opinion polling, the estimated explicit preference for straight people over lesbian women and gay men was 26% weaker on the last day compared to the first. The estimated implicit preference for straight people declined by 13.4% over the same period. The largest shifts in implicit evaluations occurred among Hispanic, White, female, liberal, and young adult participants; the smallest shifts occurred among Black, Asian, male, conservative, and older adult participants. Societal change in evaluation of lesbian and gay people is not limited to what people are willing and able to report. However, change in implicit evaluation appears to be slower.

  14. AUTOMATIC GLOBAL REGISTRATION BETWEEN AIRBORNE LIDAR DATA AND REMOTE SENSING IMAGE BASED ON STRAIGHT LINE FEATURES

    Directory of Open Access Journals (Sweden)

    Z. Q. Liu

    2018-04-01

    Full Text Available An automatic global registration approach for point clouds and remote sensing image based on straight line features is proposed which is insensitive to rotational and scale transformation. First, the building ridge lines and contour lines in point clouds are automatically detected as registration primitives by integrating region growth and topology identification. Second, the collinear condition equation is selected as registration transformation function which is based on rotation matrix described by unit quaternion. The similarity measure is established according to the distance between the corresponding straight line features from point clouds and the image in the same reference coordinate system. Finally, an iterative Hough transform is adopted to simultaneously estimate the parameters and obtain correspondence between registration primitives. Experimental results prove the proposed method is valid and the spectral information is useful for the following classification processing.

  15. Review of the analysis methods of surface crack for straight pipe and elbow

    International Nuclear Information System (INIS)

    Kim, H. S.; Jang, Y. S.; Jin, T. E.

    1999-01-01

    The objective of this paper is to find out optimum EPFM analysis methods of straight pipe and elbow by comparison of load-carrying capacities. To do this, analytical and finite element analyses were performed and then these results compared with the ones in the literatures and experimental data to verify the validity of the analysis results. Comparison results showed that NSC method for straight pipe and SC.ELB2 method for elbow were appropriate ones among analytical methods except FEM to predict load-carrying capacities. However, the trend of prediction results scattered according to the analysis conditions such as geometry and material as well as analytical methods, it is necessary for cautious application of the analytical methods

  16. #MaybeHeDoesntHitYou: Social Media Underscore the Realities of Intimate Partner Violence.

    Science.gov (United States)

    McCauley, Heather L; Bonomi, Amy E; Maas, Megan K; Bogen, Katherine W; O'Malley, Teagen L

    2018-03-22

    Public intimate partner violence (IPV) discourse emphasizes physical violence. In May 2016, the Twitter hashtag #MaybeHeDoesntHitYou generated a public conversation about abuse beyond physical IPV. Because of the often-disconnect between IPV research and what survivors struggle to name as abuse in their daily lives, we sought to understand how IPV discourse was unfolding as a result of the #MaybeHeDoesntHitYou hashtag. NCapture was used to collect publically available Twitter data containing the hashtag "#MaybeHeDoesntHitYou" from May 10, 2016 to May 17, 2016. Using the Duluth Power and Control Wheel (a range of tactics used by abusers to control and harm their partners) and the Women's Experience with Battering (WEB) framework (emotional and behavioral responses to being abused), we analyzed 1,229 original content tweets using qualitative content analysis. All dimensions of the Power and Control Wheel and five of six dimensions of the WEB framework were expressed via #MaybeHeDoesntHitYou; users did not express yearning for intimacy with their abusive partners. Users described one form of IPV not currently represented within the Power and Control Wheel-reproductive coercion (e.g., "#MaybeHeDoesntHitYou but he refuses to use condoms and forces you not to use contraception so you try to do it behind his back"). Two additional themes emerged; users challenged the gender pronoun of the hashtag, highlighting that abuse may happen with partners of all genders, and users provided social support for others (e.g., "#MaybeHeDoesntHitYou is real. Bruises and scars aren't the only measure of abuse! If this is you, help is there…"). Results from our study underscore the potential for social media platforms to be powerful agents for engaging public dialogue about the realities of IPV, as well as a space for seeking and providing social support about this critical women's health issue.

  17. PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses.

    Science.gov (United States)

    Haile, Lydia A; Rao, Roshni; Polumuri, Swamy K; Arepally, Gowthami M; Keire, David A; Verthelyi, Daniela; Sommers, Cynthia D

    2017-11-01

    Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication of heparin anticoagulation therapy resulting in thrombocytopenia frequently accompanied by thrombosis. Current evidence suggests that HIT is associated with antibodies developed in response to multi-molecular complexes formed by platelet factor 4 (PF4) bound to heparin or cell surface glycosaminoglycans. These antibody complexes activate platelets and monocytes typically through FcγRIIA receptors increasing the production of PF4, inflammatory mediators, tissue factor and thrombin. The influence of underlying events in HIT including complex-induced pro-inflammatory cell activation and structural determinants leading to local inflammatory responses are not fully understood. The stoichiometry and complex component requirements were determined by incubating fresh peripheral blood mononuclear cells (PBMC) with different concentrations of unfractionated heparin (H), low molecular weight heparin (LMWH), PF4- and anti-PF4-H complex antibodies (KKO). Cytokine mRNA or protein were measured by qRT-PCR or Meso Scale Discovery technology, respectively. Gene expression profile analysis for 594 genes was performed using Nanostring technology and analyzed using Ingenuity Pathway Analysis software. The data show that antibodies magnify immune responses induced in PBMCs by PF4 alone or in complex with heparin or LMWH. We propose that following induction of HIT antibodies by heparin-PF4 complexes, binding of the antibodies to PF4 is sufficient to induce a local pro-inflammatory response which may play a role in the progression of HIT. In vitro assays using PBMCs may be useful in characterizing local inflammatory and innate immune responses induced by HIT antibodies in the presence of PF4 and different sources of heparins. The findings and conclusions in this article are solely the responsibility of the authors and are not being formally disseminated by the Food and Drug Administration. Thus, they should not be

  18. HIT or miss: the application of health care information technology to managing uncertainty in clinical decision making.

    Science.gov (United States)

    Kazandjian, Vahé A; Lipitz-Snyderman, Allison

    2011-12-01

    To discuss the usefulness of health care information technology (HIT) in assisting care providers minimize uncertainty while simultaneously increasing efficiency of the care provided. An ongoing study of HIT, performance measurement (clinical and production efficiency) and their implications to the payment for care represents the design of this study. Since 2006, all Maryland hospitals have embarked on a multi-faceted study of performance measures and HIT adoption surveys, which will shape the health care payment model in Maryland, the last of the all-payor states, in 2011. This paper focuses on the HIT component of the Maryland care payment initiative. While the payment model is still under review and discussion, 'appropriateness' of care has been discussed as an important dimension of measurement. Within this dimension, the 'uncertainty' concept has been identified as associated with variation in care practices. Hence, the methods of this paper define how HIT can assist care providers in addressing the concept of uncertainty, and then provides findings from the first HIT survey in Maryland to infer the readiness of Maryland hospital in addressing uncertainty of care in part through the use of HIT. Maryland hospitals show noteworthy variation in their adoption and use of HIT. While computerized, electronic patient records are not commonly used among and across Maryland hospitals, many of the uses of HIT internally in each hospital could significantly assist in better communication about better practices to minimize uncertainty of care and enhance the efficiency of its production. © 2010 Blackwell Publishing Ltd.

  19. Health Information Technologies-Academic and Commercial Evaluation (HIT-ACE) methodology: description and application to clinical feedback systems.

    Science.gov (United States)

    Lyon, Aaron R; Lewis, Cara C; Melvin, Abigail; Boyd, Meredith; Nicodimos, Semret; Liu, Freda F; Jungbluth, Nathaniel

    2016-09-22

    Health information technologies (HIT) have become nearly ubiquitous in the contemporary healthcare landscape, but information about HIT development, functionality, and implementation readiness is frequently siloed. Theory-driven methods of compiling, evaluating, and integrating information from the academic and commercial sectors are necessary to guide stakeholder decision-making surrounding HIT adoption and to develop pragmatic HIT research agendas. This article presents the Health Information Technologies-Academic and Commercial Evaluation (HIT-ACE) methodology, a structured, theory-driven method for compiling and evaluating information from multiple sectors. As an example demonstration of the methodology, we apply HIT-ACE to mental and behavioral health measurement feedback systems (MFS). MFS are a specific class of HIT that support the implementation of routine outcome monitoring, an evidence-based practice. HIT-ACE is guided by theories and frameworks related to user-centered design and implementation science. The methodology involves four phases: (1) coding academic and commercial materials, (2) developer/purveyor interviews, (3) linking putative implementation mechanisms to hit capabilities, and (4) experimental testing of capabilities and mechanisms. In the current demonstration, phase 1 included a systematic process to identify MFS in mental and behavioral health using academic literature and commercial websites. Using user-centered design, implementation science, and feedback frameworks, the HIT-ACE coding system was developed, piloted, and used to review each identified system for the presence of 38 capabilities and 18 additional characteristics via a consensus coding process. Bibliometic data were also collected to examine the representation of the systems in the scientific literature. As an example, results are presented for the application of HIT-ACE phase 1 to MFS wherein 49 separate MFS were identified, reflecting a diverse array of characteristics

  20. Effect of cisplatin on proximal convoluted and straight segments of the rat kidney

    DEFF Research Database (Denmark)

    Daugaard, G; Holstein-Rathlou, N H; Leyssac, P P

    1988-01-01

    lithium clearance (CLi/Cin) and e-TT/OT was observed (from 270 +/- 32 to 387 +/- 60 microliters/min/g kidney weight, 0.202 +/- 0.03 to 0.340 +/- 0.06 and 0.415 +/- 0.02 to 0.497 +/- 0.02, respectively). These increases indicate an increased fluid delivery from both the proximal straight segment...