The Strength of the Strongest Ties in Collaborative Problem Solving

Science.gov (United States)

de Montjoye, Yves-Alexandre; Stopczynski, Arkadiusz; Shmueli, Erez; Pentland, Alex; Lehmann, Sune

2014-06-01

Complex problem solving in science, engineering, and business has become a highly collaborative endeavor. Teams of scientists or engineers collaborate on projects using their social networks to gather new ideas and feedback. Here we bridge the literature on team performance and information networks by studying teams' problem solving abilities as a function of both their within-team networks and their members' extended networks. We show that, while an assigned team's performance is strongly correlated with its networks of expressive and instrumental ties, only the strongest ties in both networks have an effect on performance. Both networks of strong ties explain more of the variance than other factors, such as measured or self-evaluated technical competencies, or the personalities of the team members. In fact, the inclusion of the network of strong ties renders these factors non-significant in the statistical analysis. Our results have consequences for the organization of teams of scientists, engineers, and other knowledge workers tackling today's most complex problems.

Analyzing negative ties in social networks

Directory of Open Access Journals (Sweden)

Mankirat Kaur

2016-03-01

Full Text Available Online social networks are a source of sharing information and maintaining personal contacts with other people through social interactions and thus forming virtual communities online. Social networks are crowded with positive and negative relations. Positive relations are formed by support, endorsement and friendship and thus, create a network of well-connected users whereas negative relations are a result of opposition, distrust and avoidance creating disconnected networks. Due to increase in illegal activities such as masquerading, conspiring and creating fake profiles on online social networks, exploring and analyzing these negative activities becomes the need of hour. Usually negative ties are treated in same way as positive ties in many theories such as balance theory and blockmodeling analysis. But the standard concepts of social network analysis do not yield same results in respect of each tie. This paper presents a survey on analyzing negative ties in social networks through various types of network analysis techniques that are used for examining ties such as status, centrality and power measures. Due to the difference in characteristics of flow in positive and negative tie networks some of these measures are not applicable on negative ties. This paper also discusses new methods that have been developed specifically for analyzing negative ties such as negative degree, and h∗ measure along with the measures based on mixture of positive and negative ties. The different types of social network analysis approaches have been reviewed and compared to determine the best approach that can appropriately identify the negative ties in online networks. It has been analyzed that only few measures such as Degree and PN centrality are applicable for identifying outsiders in network. For applicability in online networks, the performance of PN measure needs to be verified and further, new measures should be developed based upon negative clique concept.

Dynamic risk analysis using bow-tie approach

International Nuclear Information System (INIS)

Khakzad, Nima; Khan, Faisal; Amyotte, Paul

2012-01-01

Accident probability estimation is a common and central step to all quantitative risk assessment methods. Among many techniques available, bow-tie model (BT) is very popular because it represent the accident scenario altogether including causes and consequences. However, it suffers a static structure limiting its application in real-time monitoring and probability updating which are key factors in dynamic risk analysis. The present work is focused on using BT approach in a dynamic environment in which the occurrence probability of accident consequences changes. In this method, on one hand, failure probability of primary events of BT, leading to the top event, are developed using physical reliability models, and constantly revised as physical parameters (e.g., pressure, velocity, dimension, etc) change. And, on the other hand, the failure probability of safety barriers of the BT are periodically updated using Bayes’ theorem as new information becomes available over time. Finally, the resulting, updated BT is used to estimate the posterior probability of the consequences which in turn results in an updated risk profile. - Highlights: ► A methodology is proposed to make bow-tie method adapted for dynamic risk analysis. ► Physical reliability models are used to revise the top event. ► Bayes’ theorem is used to update the probability of safety barriers. ► The number of accidents in sequential time intervals is used to form likelihood function. ► The risk profile is updated for varying physical parameters and for different times.

Anatomical contributions to plant taxonomy II. The affinities of Hua Pierre and Afrostyrax Perkins et Gilg

NARCIS (Netherlands)

Baas, P.

1972-01-01

Vegetative anatomy, fruit and seed structure, and pollen morphology of Hua and Afrostyrax (tropical West and Central Africa) are described in detail. The two genera have many anatomical characters in common (see anatomical family diagnosis on p. 182) but are sufficiently different from other

High tie versus low tie of the inferior mesenteric artery in colorectal cancer: A meta-analysis.

Science.gov (United States)

Yang, Yafan; Wang, Guiying; He, Jingli; Zhang, Jianfeng; Xi, Jinchuan; Wang, Feifei

2018-04-01

Colorectal cancer surgery includes "high tie" and "low tie"of the inferior mesenteric artery(IMA). However, different ligation level is closely related to the blood supply of anastomosis, which may increase the leakage rate, and it is unclear which technique confers a lower anastomotic leakage rate(AL) and survival advantage. To compare the effectiveness and impact of inferior mesenteric artery (IMA) high ligation versus IMA low ligation on anastomotic leakage, lymph nodes yield rates and 5-year survival. A list of these studies, published in English from 1990 to 2017, was obtained independently by two reviewers from databases such as PubMed, Medline, ScienceDirect and Web of Science. Anastomotic leakage rate, the yield of lymph nodes and 5-year survival were compared using Review Manager 5.3. There was no significant difference in anastomotic leakage, number of lymph nodes retrieved and 5-year survival rate for both techniques. Neither the high tie nor the low tie strategy has an evidence in terms of anastomotic leakage rate, harvested lymph nodes, and the 5-year survival rate. Further RCT is needed. Copyright © 2018 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

Why do leaf-tying caterpillars abandon their leaf ties?

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Michelle Sliwinski

2013-09-01

Full Text Available Leaf-tying caterpillars act as ecosystem engineers by building shelters between overlapping leaves, which are inhabited by other arthropods. Leaf-tiers have been observed to leave their ties and create new shelters (and thus additional microhabitats, but the ecological factors affecting shelter fidelity are poorly known. For this study, we explored the effects of resource limitation and occupant density on shelter fidelity and assessed the consequences of shelter abandonment. We first quantified the area of leaf material required for a caterpillar to fully develop for two of the most common leaf-tiers that feed on white oak, Quercus alba. On average, Psilocorsis spp. caterpillars consumed 21.65 ± 0.67 cm2 leaf material to complete development. We also measured the area of natural leaf ties found in a Maryland forest, to determine the distribution of resources available to caterpillars in situ. Of 158 natural leaf ties examined, 47% were too small to sustain an average Psilocorsis spp. caterpillar for the entirety of its development. We also manipulated caterpillar densities within experimental ties on potted trees to determine the effects of cohabitants on the likelihood of a caterpillar to leave its tie. We placed 1, 2, or 4 caterpillars in ties of a standard size and monitored the caterpillars twice daily to track their movement. In ties with more than one occupant, caterpillars showed a significantly greater propensity to leave their tie, and left sooner and at a faster rate than those in ties as single occupants. To understand the consequences of leaf tie abandonment, we observed caterpillars searching a tree for a site to build a shelter in the field. This is a risky behavior, as 17% of the caterpillars observed died while searching for a shelter site. Caterpillars that successfully built a shelter traveled 110 ± 20 cm and took 28 ± 7 min to find a suitable site to build a shelter. In conclusion, leaf-tying caterpillars must frequently

The Popularity of Picture Books with Television Tie-in

Directory of Open Access Journals (Sweden)

Patricia R. Ladd

2011-06-01

Full Text Available This study analyzes circulation statistics of television tie-in picture books from the Wake County Public Library System in North Carolina to determine their popularity among patrons. Caldecott winning picture books were used as a point of comparison. This study also examined OPAC holdings from North Carolina public libraries to determine television tie-in picture book popularity among collection builders. The findings of the study show that television tie-in picture books are found to some degree in the vast majority of North Carolina public libraries, and are more popular than award winners in the Wake County system.

A novel approach to the pharmacodynamic modelling of 131I-HUA33 antibody in patients with colorectal carcinoma

International Nuclear Information System (INIS)

Papenfuss, A.T.; Chong, G.; Schleyer, P.; O'Keefe, G.J.; Scott, A.M.

2003-01-01

Full text: The humanised monoclonal antibody, huA33, has been the subject of intense investigation as a candidate for targeted radiotherapy. HuA33 exhibits strong uptake by colorectal cancers for up to 6 weeks post-infusion, and also by normal colonic epithelium, however colon clearance occurs within a 1-2 week period. This is reflected in the lack of gastro-intestinal toxicity in previous trials of 131 I-murine A33. Models of huA33 normal tissue uptake and excretion, which are useful tools for determining time activity curves and organ residence times, are complicated by the fact that colonic epithelial cells are shed when they reach the age of 6-7 days. This can, in principle, be approximated by an exponential loss term from a colon compartment. The problem with such a simple model is in accurately estimating the loss rate. A novel approach is introduced here in which the colonic epithelium is not represented by a single well-mixed compartment, but instead by an average over many sub-compartments. Each sub-compartment represents colon epithelial cells of a single age. When the age a sub-compartment reaches the average lifetime of a colonic epithelial cell, the sub-compartment is emptied. Numerical results based on autoradiography and planar imaging of a colon, surgically resected one week after infusion of labelled antibody are shown. Copyright (2003) The Australian and New Zealand Society of Nuclear Medicine Inc

Organizing learning processes on risks by using the bow-tie representation

Energy Technology Data Exchange (ETDEWEB)

Chevreau, F.R. [Ecole des Mines de Paris, 06904 Sophia-Antipolis (France)]. E-mail: chevreau@cindy.ensmp.fr; Wybo, J.L. [Ecole des Mines de Paris, 06904 Sophia-Antipolis (France)]. E-mail: wybo@cindy.ensmp.fr; Cauchois, D. [Process Safety Department, Sanofi-Aventis, Site de Production de Vitry sur Seine, 9 Quai Jules Guesdes, 94400 Vitry sur Seine (France)]. E-mail: didier.cauchois@sanofi-aventis.com

2006-03-31

The Aramis method proposes a complete and efficient way to manage risk analysis by using the bow-tie representation. This paper shows how the bow-tie representation can also be appropriate for experience learning. It describes how a pharmaceutical production plant uses bow-ties for incident and accident analysis. Two levels of bow-ties are constructed: standard bow-ties concern generic risks of the plant whereas local bow-ties represent accident scenarios specific to each workplace. When incidents or accidents are analyzed, knowledge that is gained is added to existing local bow-ties. Regularly, local bow-ties that have been updated are compared to standard bow-ties in order to revise them. Knowledge on safety at the global and at local levels is hence as accurate as possible and memorized in a real time framework. As it relies on the communication between safety experts and local operators, this use of the bow-ties contributes therefore to organizational learning for safety.

Organizing learning processes on risks by using the bow-tie representation

International Nuclear Information System (INIS)

Chevreau, F.R.; Wybo, J.L.; Cauchois, D.

2006-01-01

The Aramis method proposes a complete and efficient way to manage risk analysis by using the bow-tie representation. This paper shows how the bow-tie representation can also be appropriate for experience learning. It describes how a pharmaceutical production plant uses bow-ties for incident and accident analysis. Two levels of bow-ties are constructed: standard bow-ties concern generic risks of the plant whereas local bow-ties represent accident scenarios specific to each workplace. When incidents or accidents are analyzed, knowledge that is gained is added to existing local bow-ties. Regularly, local bow-ties that have been updated are compared to standard bow-ties in order to revise them. Knowledge on safety at the global and at local levels is hence as accurate as possible and memorized in a real time framework. As it relies on the communication between safety experts and local operators, this use of the bow-ties contributes therefore to organizational learning for safety

Social network ties beyond nonredundancy: an experimental investigation of the effect of knowledge content and tie strength on creativity.

Science.gov (United States)

Perry-Smith, Jill E

2014-09-01

Social network research emphasizes the access to nonredundant knowledge content that network ties provide. I suggest that some content is more beneficial than others and that tie strength may affect creativity for reasons other than the associated structure. That is, tie strength may affect how individuals process nonredundant knowledge. I investigate 2 types of knowledge content--information (i.e., facts or data) and frames (i.e., interpretations or impressions)--and explore whether tie strength influences their effect on creativity. Drawing on creativity theory, I employ an experimental design to provide greater theoretical clarity and to isolate causality. According to the results from 2 studies, distinct frames received from contacts facilitate creativity, but the effect of distinct information is more complex. When individuals receive distinct information from strong ties, it constrains creativity compared to distinct frames. Content from weak ties appears to facilitate creativity across all scenarios. The results of mediated moderation analysis indicate the effect of framing versus information for strong ties is driven by decision-making time, as an indicator of cognitive expansion. PsycINFO Database Record (c) 2014 APA, all rights reserved.

More ties than we thought

Directory of Open Access Journals (Sweden)

Dan Hirsch

2015-05-01

Full Text Available We extend the existing enumeration of neck tie-knots to include tie-knots with a textured front, tied with the narrow end of a tie. These tie-knots have gained popularity in recent years, based on reconstructions of a costume detail from The Matrix Reloaded, and are explicitly ruled out in the enumeration by Fink & Mao (2000. We show that the relaxed tie-knot description language that comprehensively describes these extended tie-knot classes is context free. It has a regular sub-language that covers all the knots that originally inspired the work. From the full language, we enumerate 266,682 distinct tie-knots that seem tie-able with a normal neck-tie. Out of these 266,682, we also enumerate 24,882 tie-knots that belong to the regular sub-language.

Performance analysis of new type grid-tied inverter-Aalborg Inverter

DEFF Research Database (Denmark)

Wu, Weimin; Wang, Zhen; Ji, Junhao

2014-01-01

Aalborg Inverter is a grid-tied DC/AC inverter. In order to optimize the design, its power losses are analyzed in detail, combined with a description of the single-phase operating principle and the modulation strategy. A 2 kW / 220 V experimental prototype is constructed to verify the theoretical...... analysis. It is concluded that a minimize inductance in the power loop does help the inverter to achieve the high efficiency with the good dynamic performance....

EVALUATION OF PHOTOGRAMMETRIC BLOCK ORIENTATION USING QUALITY DESCRIPTORS FROM STATISTICALLY FILTERED TIE POINTS

Directory of Open Access Journals (Sweden)

A. Calantropio

2018-05-01

Full Text Available Due to the increasing number of low-cost sensors, widely accessible on the market, and because of the supposed granted correctness of the semi-automatic workflow for 3D reconstruction, highly implemented in the recent commercial software, more and more users operate nowadays without following the rigorousness of classical photogrammetric methods. This behaviour often naively leads to 3D products that lacks metric quality assessment. This paper proposes and analyses an approach that gives the users the possibility to preserve the trustworthiness of the metric information inherent in the 3D model, without sacrificing the automation offered by modern photogrammetry software. At the beginning, the importance of Data Quality Assessment is outlined, together with some recall of photogrammetry best practices. With the purpose of guiding the user through a correct pipeline for a certified 3D model reconstruction, an operative workflow is proposed, focusing on the first part of the object reconstruction steps (tie-points extraction, camera calibration, and relative orientation. A new GUI (Graphical User Interface developed for the open source MicMac suite is then presented, and a sample dataset is used for the evaluation of the photogrammetric block orientation using statistically obtained quality descriptors. The results and the future directions are then presented and discussed.

Risk analysis of urban gas pipeline network based on improved bow-tie model

Science.gov (United States)

Hao, M. J.; You, Q. J.; Yue, Z.

2017-11-01

Gas pipeline network is a major hazard source in urban areas. In the event of an accident, there could be grave consequences. In order to understand more clearly the causes and consequences of gas pipeline network accidents, and to develop prevention and mitigation measures, the author puts forward the application of improved bow-tie model to analyze risks of urban gas pipeline network. The improved bow-tie model analyzes accident causes from four aspects: human, materials, environment and management; it also analyzes the consequences from four aspects: casualty, property loss, environment and society. Then it quantifies the causes and consequences. Risk identification, risk analysis, risk assessment, risk control, and risk management will be clearly shown in the model figures. Then it can suggest prevention and mitigation measures accordingly to help reduce accident rate of gas pipeline network. The results show that the whole process of an accident can be visually investigated using the bow-tie model. It can also provide reasons for and predict consequences of an unfortunate event. It is of great significance in order to analyze leakage failure of gas pipeline network.

Analysis of Silver Ink Bow-Tie RFID Tag Antennas Printed on Paper Substrates

Directory of Open Access Journals (Sweden)

Sari Merilampi

2007-01-01

Full Text Available In this study, polymeric silver inks, paper substrates, and screen printing were used to produce prototype Bow-Tie tags. Because of increasing interest in applying passive UHF-RFID systems in paper industry, the Bow-Tie antenna used in this study was designed to work through paper. The maximum reliable read ranges of the tags were measured thorough stacked paper and also in air. The analysis and functioning of the antenna design are also discussed. All inks and paper substrates were suitable as antenna material and the prototype tag antennas had good reading performance. The maximum reliable read ranges were quite the same as for copper and aluminum tags studied elsewhere. This means that printed UHF tags are competitive solutions for the identification of simple mass products.

Excited collective states of nuclei within Bohr Hamiltonian with Tietz-Hua potential

Energy Technology Data Exchange (ETDEWEB)

Chabab, M.; El Batoul, A.; Lahbas, A.; Oulne, M. [Cadi Ayyad University, High Energy Physics and Astrophysics Laboratory, Faculty of Sciences Semlalia, Marrakesh (Morocco); Hamzavi, M. [University of Zanjan, Department of Physics, Zanjan (Iran, Islamic Republic of)

2017-07-15

In this paper, we present new analytical solutions of the Bohr Hamiltonian problem that we derived with the Tietz-Hua potential, here used for describing the β-part of the nuclear collective potential plus that of the harmonic oscillator for the γ-part. Also, we proceed to a systematic comparison of the numerical results obtained with this kind of β-potential with others which are widely used in such a framework as well as with the experiment. The calculations are carried out for energy spectra and electromagnetic transition probabilities for γ-unstable and axially symmetric deformed nuclei. In the same frame, we show the effect of the shape flatness of the β-potential beyond its minimum on transition rates calculations. (orig.)

Network ties and survival

DEFF Research Database (Denmark)

Acheampong, George; Narteh, Bedman; Rand, John

2017-01-01

Poultry farming has been touted as one of the major ways by which poverty can be reduced in low-income economies like Ghana. Yet, anecdotally there is a high failure rate among these poultry farms. This current study seeks to understand the relationship between network ties and survival chances...... of small commercial poultry farms (SCPFs). We utilize data from a 2-year network survey of SCPFs in rural Ghana. The survival of these poultry farms are modelled using a lagged probit model of farms that persisted from 2014 into 2015. We find that network ties are important to the survival chances...... but this probability reduces as the number of industry ties increases but moderation with dynamic capability of the firm reverses this trend. Our findings show that not all network ties aid survival and therefore small commercial poultry farmers need to be circumspect in the network ties they cultivate and develop....

Strong Ties, Weak Ties, and Human Capital: Latino Immigrant Employment outside the Enclave

Science.gov (United States)

Pfeffer, Max J.; Parra, Pilar A.

2009-01-01

This study focuses on the role of social ties and human capital in the integration of Latino immigrants into the local economy. This analysis extends earlier research by focusing on more rural contexts with limited labor-market opportunities and less access to social resources provided by coethnics. We reconsider conclusions of previous studies by…

Square and bow-tie configurations in the cyclic evasion problem

Science.gov (United States)

Arnold, M. D.; Golich, M.; Grim, A.; Vargas, L.; Zharnitsky, V.

2017-05-01

Cyclic evasion of four agents on the plane is considered. There are two stationary shapes of configurations: square and degenerate bow-tie. The bow-tie is asymptotically attracting while the square is of focus-center type. Normal form analysis shows that square is nonlinearly unstable. The stable manifold consists of parallelograms that all converge to the square configuration. Based on these observations and numerical simulations, it is conjectured that any non-parallelogram non-degenerate configuration converges to the bow-tie.

TIE-2 and VEGFR kinase activities drive immunosuppressive function of TIE-2-expressing monocytes in human breast tumors.

Science.gov (United States)

Ibberson, Mark; Bron, Sylvian; Guex, Nicolas; Faes-van't Hull, Eveline; Ifticene-Treboux, Assia; Henry, Luc; Lehr, Hans-Anton; Delaloye, Jean-François; Coukos, George; Xenarios, Ioannis; Doucey, Marie-Agnès

2013-07-01

Tumor-associated TIE-2-expressing monocytes (TEM) are highly proangiogenic cells critical for tumor vascularization. We previously showed that, in human breast cancer, TIE-2 and VEGFR pathways control proangiogenic activity of TEMs. Here, we examine the contribution of these pathways to immunosuppressive activity of TEMs. We investigated the changes in immunosuppressive activity of TEMs and gene expression in response to specific kinase inhibitors of TIE-2 and VEGFR. The ability of tumor TEMs to suppress tumor-specific T-cell response mediated by tumor dendritic cells (DC) was measured in vitro. Characterization of TEM and DC phenotype in addition to their interaction with T cells was done using confocal microscopic images analysis of breast carcinomas. TEMs from breast tumors are able to suppress tumor-specific immune responses. Importantly, proangiogenic and suppressive functions of TEMs are similarly driven by TIE-2 and VEGFR kinase activity. Furthermore, we show that tumor TEMs can function as antigen-presenting cells and elicit a weak proliferation of T cells. Blocking TIE-2 and VEGFR kinase activity induced TEMs to change their phenotype into cells with features of myeloid dendritic cells. We show that immunosuppressive activity of TEMs is associated with high CD86 surface expression and extensive engagement of T regulatory cells in breast tumors. TIE-2 and VEGFR kinase activity was also necessary to maintain high CD86 surface expression levels and to convert T cells into regulatory cells. These results suggest that TEMs are plastic cells that can be reverted from suppressive, proangiogenic cells into cells that are able to mediate an antitumoral immune response. ©2013 AACR.

PWR integral tie plate and locking mechanism

International Nuclear Information System (INIS)

Flora, B.S.; Osborne, J.L.

1980-01-01

A locking mechanism for securing an upper tie plate to the tie rods of a nuclear fuel bundle is described. The mechanism includes an upper tie plate assembly and locking sleeves fixed to the ends of the tie rods. The tie plate is part of the upper tie plate assembly and is secured to the fuel bundle by securing the entire upper tie plate assembly to the locking sleeves fixed to the tie rods. The assembly includes, in addition to the tie plate, locking nuts for engaging the locking sleeves, retaining sleeves to operably connect the locking nuts to the assembly, a spring biased reaction plate to restrain the locking nuts in the locked position and a means to facilitate the removal of the entire assembly as a unit from the fuel bundle

Application of Bow-tie methodology to improve patient safety.

Science.gov (United States)

Abdi, Zhaleh; Ravaghi, Hamid; Abbasi, Mohsen; Delgoshaei, Bahram; Esfandiari, Somayeh

2016-05-09

Purpose - The purpose of this paper is to apply Bow-tie methodology, a proactive risk assessment technique based on systemic approach, for prospective analysis of the risks threatening patient safety in intensive care unit (ICU). Design/methodology/approach - Bow-tie methodology was used to manage clinical risks threatening patient safety by a multidisciplinary team in the ICU. The Bow-tie analysis was conducted on incidents related to high-alert medications, ventilator associated pneumonia, catheter-related blood stream infection, urinary tract infection, and unwanted extubation. Findings - In total, 48 potential adverse events were analysed. The causal factors were identified and classified into relevant categories. The number and effectiveness of existing preventive and protective barriers were examined for each potential adverse event. The adverse events were evaluated according to the risk criteria and a set of interventions were proposed with the aim of improving the existing barriers or implementing new barriers. A number of recommendations were implemented in the ICU, while considering their feasibility. Originality/value - The application of Bow-tie methodology led to practical recommendations to eliminate or control the hazards identified. It also contributed to better understanding of hazard prevention and protection required for safe operations in clinical settings.

Tie Content in Professional Networks

DEFF Research Database (Denmark)

Zarzecka, Olga

in resource exchanges and the effect of these differences on the number of, and extent to which, resources are provided by a network tie. Chapter 3 explores how firm underperfomance and social identity with corporate elite alter types of resources a network tie provides. Chapter 4 focuses on a tie’s internal......Professional networks of senior managers have indisputable value for them as well as for their organizations. In recent years, much attention has been given to the structure of these networks as it reflects senior managers’ opportunity to access valuable resources. Surprisingly, the actual...... resources that senior managers acquire through their network ties, i.e. the tie content, remain heavily understudied. Hence, the purpose of this dissertation is to answer the following question: What resources flow through informal ties in senior managers’ professional networks, and why? The first chapter...

23 CFR 635.111 - Tied bids.

Science.gov (United States)

2010-04-01

... MAINTENANCE Contract Procedures § 635.111 Tied bids. (a) The STD may tie or permit the tying of Federal-aid...-financed highway projects may be combined in one contract if the conditions of the projects are so similar...

Towards the identification of alkaline phosphatase binding ligands in Li-Dan-Hua-Shi pills: A Box-Behnken design optimized affinity selection approach tandem with UHPLC-Q-TOF/MS analysis.

Science.gov (United States)

Tao, Yi; Huang, Surun; Gu, Xianghui; Li, Weidong; Cai, Baochang

2018-05-30

Alkaline phosphatase conjugated magnetic microspheres were synthesized via amide reaction, and employed as an effective adsorbent in affinity selection of binding ligands followed by UHPLC-Q-TOF/MS analysis. The analytical validity of the developed approach was evaluated under optimized conditions and the following figures of merit were obtained: linearity, 0.01-0.5 g L -1 with good determination coefficients (R 2  = 0.9992); limits of detection (LODs), 0.003 g L -1 ; and limits of quantitation (LOQ), 0.01 g L -1 . The precision (RSD%) of the proposed affinity selection approach was studied based on intra-day (0.8%) and inter-day (1.3%) precisions. Finally, the adsorbent was successfully applied to identification of binding ligands in Li-Dan-Hua-Shi pills and good recoveries were obtained in the range from 96.9 to 99.4% (RSDs 1.6-3.0%). Copyright © 2018 Elsevier B.V. All rights reserved.

Social Ties for Labor Market Access

DEFF Research Database (Denmark)

Dorner, Matthias; Harhoff, Dietmar; Hinz, Tina

such ties. However, mobility decisions made by inventors with outstanding patenting track records (star inventors) were not impacted by social ties. We conclude that social ties support labor market access for migrant inventors and determine regional choices while dependence on these ties is substantially......We study the impact of social ties on the migration of inventors from East to West Germany, using the fall of the Iron Curtain and German reunification as a natural experiment. We identify East German inventors via their patenting track records prior to 1990 and their social security records...... in the German labor market after reunification. Modeling inventor migration to West German regions after 1990, we find that Western regions with stronger historically determined social ties across the former East-West border attracted more inventors after the fall of the Iron Curtain than regions without...

Studi Tentang Political Tie, Pengaruhnya Terhadap Keputusan Pemberian Kredit Bank di Indonesia

Directory of Open Access Journals (Sweden)

Elisa Tjondro

2012-01-01

Full Text Available This study uses bank loan data to examine the effect of (political tie between the company and the government to on the assessment of companies financial leverage and profitability in the bank lending decisions in Indonesia. The numbers of samples are 1465 observations. This study uses moderated regression analysis (MRA. The study finds that a political tie affect corporate profitability assessment in bank lending decisions. Firms with lower profitability receive larger bank loan because their political tie (rent-seeking hypothesis. However, this study inds that a political tie does not affect the assessment of financial leverage in bank's lending decisions. This finding also supports Faccio (2010, Fisman (2001, and Backman (2001. Indonesia condition which has a weak institutional regulation and high information asymmetry is beneficial for companies that have a political tie. This leads to more trusted political tie as an indicator of the profitability.

Open knot-tying skills: residents skills assessed

NARCIS (Netherlands)

van Empel, P.J.; Verdam, M.G.E.; Huirne, J.A.; Bonjer, H.J.; Meijerink, W.J.; Scheele, F.

2013-01-01

Aim: Open knot-tying and suturing skills are fundamental surgical skills, founding many alternative knot-tying techniques. It is therefore mandatory for residents to possess adequate basic open knot-tying skills. The aim of this study was to compare an objective assessment of open knot-tying skills

Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study.

Science.gov (United States)

Ahn, Rosa; Woodbridge, Alexandra; Abraham, Ann; Saba, Susan; Korenstein, Deborah; Madden, Erin; Boscardin, W John; Keyhani, Salomeh

2017-01-17

 To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding.  Cross sectional study of randomized controlled trials (RCTs).  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013.  Random sample of RCTs focused on drug efficacy.  Association between financial ties of principal investigators and study outcome.  A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present in 132 (67.7%) studies. Of 397 principal investigators, 231 (58%) had financial ties and 166 (42%) did not. Of all principal investigators, 156 (39%) reported advisor/consultancy payments, 81 (20%) reported speakers' fees, 81 (20%) reported unspecified financial ties, 52 (13%) reported honorariums, 52 (13%) reported employee relationships, 52 (13%) reported travel fees, 41 (10%) reported stock ownership, and 20 (5%) reported having a patent related to the study drug. The prevalence of financial ties of principal investigators was 76% (103/136) among positive studies and 49% (29/59) among negative studies. In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). The secondary analysis controlled for additional RCT characteristics such as study phase, sample size, country of first authors, specialty, trial registration, study design, type of analysis, comparator, and outcome measure. These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1

Relationships between authorship contributions and authors' industry financial ties among oncology clinical trials.

Science.gov (United States)

Rose, Susannah L; Krzyzanowska, Monika K; Joffe, Steven

2010-03-10

PURPOSE To test the hypothesis that authors who play key scientific roles in oncology clinical trials, and who therefore have increased influence over the design, analysis, interpretation or reporting of trials, are more likely than those who do not play such roles to have financial ties to industry. METHODS Data were abstracted from all trials (n = 235) of drugs or biologic agents published in the Journal of Clinical Oncology between January 1, 2006 and June 30, 2007. Article-level data included sponsorship, age group (adult v pediatric), phase, single versus multicenter, country (United States v other), and number of authors. Author-level data (n = 2,927) included financial ties (eg, employment, consulting) and performance of key scientific roles (ie, conception/design, analysis/interpretation, or manuscript writing). Associations between performance of key roles and financial ties, adjusting for article-level covariates, were examined using generalized linear mixed models. Results One thousand eight hundred eighty-one authors (64%) reported performing at least one key role, and 842 authors (29%) reported at least one financial tie. Authors who reported performing a key role were more likely than other authors to report financial ties to industry (adjusted odds ratio [OR], 4.3; 99% CI, 3.0 to 6.0; P analysis, and interpretation, or reporting of oncology clinical trials are more likely than authors who do not perform such roles to have financial ties to industry.

Instability of ties in compression

DEFF Research Database (Denmark)

Buch-Hansen, Thomas Cornelius

2013-01-01

Masonry cavity walls are loaded by wind pressure and vertical load from upper floors. These loads results in bending moments and compression forces in the ties connecting the outer and the inner wall in a cavity wall. Large cavity walls are furthermore loaded by differential movements from...... the temperature gradient between the outer and the inner wall, which results in critical increase of the bending moments in the ties. Since the ties are loaded by combined compression and moment forces, the loadbearing capacity is derived from instability equilibrium equations. Most of them are iterative, since...... exact instability solutions are complex to derive, not to mention the extra complexity introducing dimensional instability from the temperature gradients. Using an inverse variable substitution and comparing an exact theory with an analytical instability solution a method to design tie...

Statistical data analysis using SAS intermediate statistical methods

CERN Document Server

Marasinghe, Mervyn G

2018-01-01

The aim of this textbook (previously titled SAS for Data Analytics) is to teach the use of SAS for statistical analysis of data for advanced undergraduate and graduate students in statistics, data science, and disciplines involving analyzing data. The book begins with an introduction beyond the basics of SAS, illustrated with non-trivial, real-world, worked examples. It proceeds to SAS programming and applications, SAS graphics, statistical analysis of regression models, analysis of variance models, analysis of variance with random and mixed effects models, and then takes the discussion beyond regression and analysis of variance to conclude. Pedagogically, the authors introduce theory and methodological basis topic by topic, present a problem as an application, followed by a SAS analysis of the data provided and a discussion of results. The text focuses on applied statistical problems and methods. Key features include: end of chapter exercises, downloadable SAS code and data sets, and advanced material suitab...

Understanding the process of social network evolution: Online-offline integrated analysis of social tie formation.

Science.gov (United States)

Kwak, Doyeon; Kim, Wonjoon

2017-01-01

It is important to consider the interweaving nature of online and offline social networks when we examine social network evolution. However, it is difficult to find any research that examines the process of social tie formation from an integrated perspective. In our study, we quantitatively measure offline interactions and examine the corresponding evolution of online social network in order to understand the significance of interrelationship between online and offline social factors in generating social ties. We analyze the radio signal strength indicator sensor data from a series of social events to understand offline interactions among the participants and measure the structural attributes of their existing online Facebook social networks. By monitoring the changes in their online social networks before and after offline interactions in a series of social events, we verify that the ability to develop an offline interaction into an online friendship is tied to the number of social connections that participants previously had, while the presence of shared mutual friends between a pair of participants disrupts potential new connections within the pre-designed offline social events. Thus, while our integrative approach enables us to confirm the theory of preferential attachment in the process of network formation, the common neighbor theory is not supported. Our dual-dimensional network analysis allows us to observe the actual process of social network evolution rather than to make predictions based on the assumption of self-organizing networks.

Understanding the process of social network evolution: Online-offline integrated analysis of social tie formation.

Directory of Open Access Journals (Sweden)

Doyeon Kwak

Full Text Available It is important to consider the interweaving nature of online and offline social networks when we examine social network evolution. However, it is difficult to find any research that examines the process of social tie formation from an integrated perspective. In our study, we quantitatively measure offline interactions and examine the corresponding evolution of online social network in order to understand the significance of interrelationship between online and offline social factors in generating social ties. We analyze the radio signal strength indicator sensor data from a series of social events to understand offline interactions among the participants and measure the structural attributes of their existing online Facebook social networks. By monitoring the changes in their online social networks before and after offline interactions in a series of social events, we verify that the ability to develop an offline interaction into an online friendship is tied to the number of social connections that participants previously had, while the presence of shared mutual friends between a pair of participants disrupts potential new connections within the pre-designed offline social events. Thus, while our integrative approach enables us to confirm the theory of preferential attachment in the process of network formation, the common neighbor theory is not supported. Our dual-dimensional network analysis allows us to observe the actual process of social network evolution rather than to make predictions based on the assumption of self-organizing networks.

Social support and social interaction ties on internet addiction: integrating online and offline contexts.

Science.gov (United States)

Wang, Edward Shih-Tse; Wang, Michael Chih-Hung

2013-11-01

This study explores the relationship between social support and social interaction ties on Internet addiction by integrating both online and offline social encounters. A total of 1,642 members of online social communities participated in this research, for which structural equation modeling was used for analysis. The findings show that social support is positively associated with social interaction ties in both online and offline contexts. In addition, online social support and online social interaction ties are positively associated with Internet addiction, whereas offline social support and social interaction ties on Internet addiction are negatively associated. This finding has important implications not only for understanding the cause of Internet addiction but also for understanding the diminishing Internet addiction due to social support and social interaction ties.

Family ties and residential locations

NARCIS (Netherlands)

Mulder, C.H.; Cooke, T.J.

2009-01-01

In this paper, and in the Special Issue it introduces, the focus is on the role of family ties in residential location choice and, conversely, the role of residential locations in maintaining family ties. Not only do events in the nuclear family trigger residential relocations, but nearby family

Software With Strong Ties to Space

Science.gov (United States)

2003-01-01

TieFlow is a simple but powerful business process improvement solution. It can automate and simplify any generic or industry-specific work process, helping organizations to transform work inefficiencies and internal operations involving people, paper, and procedures into a streamlined, well-organized, electronicbased process. TieFlow increases business productivity by improving process cycle times. The software can expedite generic processes in the areas of product design and development, purchase orders, expense reports, benefits enrollment, budgeting, hiring, and sales. It can also shore up vertical market processes such as claims processing, loan application and processing, health care administration, contract management, and advertising agency traffic. The processes can be easily and rapidly captured in a graphical manner and enforced together with rules pertaining to assignments that need to be performed. Aside from boosting productivity, TieFlow also reduces organizational costs and errors. TieFlow was developed with Small Business Innovation Research (SBIR) assistance from Johnson. The SBIR support entitles all Federal Government agencies to utilize the TieFlow software technology free of charge. Tietronix emphasizes that TieFlow is an outstanding workflow resource that could produce dramatic productivity and cost improvements for all agencies, just as it has done and continues to do for NASA. The Space Agency is currently using the software throughout several mission-critical offices, including the Mission Operations Directorate and the Flight Director s Office, for worldwide participation of authorized users in NASA processes. At the Flight Director s Office, TieFlow allows personnel to electronically submit and review changes to the flight rules carried out during missions.

Multicentre randomised double bind crossover trial on contamination of conventional ties and bow ties in routine obstetric and gynaecological practice.

Science.gov (United States)

Biljan, M M; Hart, C A; Sunderland, D; Manasse, P R; Kingsland, C R

1993-01-01

OBJECTIVE--To assess level of contamination of neckwear worn by gynaecologists and obstetricians during routine working week. DESIGN--Multicentre randomised double blind crossover trial. Participants wore the same conventional ties for three days in one week and bow ties for the same period in second week. SETTING--Two teaching and three district general hospitals in the midlands, Wales, and north England. SUBJECTS--15 registrars and senior registrars. INTERVENTIONS--A swab soaked in sterile saline was taken from specific area on ties at end of first and third working days and sent in transport medium for culture on chocolatised blood and MacConkey agar for 48 hours. MAIN OUTCOME MEASURES--Level of bacteriological growth assessed semiquantitatively (0 for no contamination; for heavy contamination) after swabs had been cultured. At end of study the participants completed a questionnaire to assess their attitude toward wearing different types of necktie. RESULTS--12 doctors (80%) completed the study. Although bow ties were significantly less contaminated at end of first working day (z = -2.354, p = 0.019), this difference was not maintained; there was no difference in level of contamination on third day. Level of contamination did not increase between first and third day of wearing the same garment. One of the 10 doctors who returned the questionnaire found the bow tie very uncomfortable. All participants would consider wearing a bow tie if it proved to be less contaminated than a conventional tie. CONCLUSIONS--Although a significant difference in contamination was established between conventional and bow ties on first day of study, this difference was not confirmed on third day and there is unlikely to be any real association between tie type and bacterial contamination. Because of its negative image and difficulty to tie, the bow tie will probably remain a minority fashion. Images p1583-a PMID:8292945

Evolution of bow-tie architectures in biology.

Directory of Open Access Journals (Sweden)

Tamar Friedlander

2015-03-01

Full Text Available Bow-tie or hourglass structure is a common architectural feature found in many biological systems. A bow-tie in a multi-layered structure occurs when intermediate layers have much fewer components than the input and output layers. Examples include metabolism where a handful of building blocks mediate between multiple input nutrients and multiple output biomass components, and signaling networks where information from numerous receptor types passes through a small set of signaling pathways to regulate multiple output genes. Little is known, however, about how bow-tie architectures evolve. Here, we address the evolution of bow-tie architectures using simulations of multi-layered systems evolving to fulfill a given input-output goal. We find that bow-ties spontaneously evolve when the information in the evolutionary goal can be compressed. Mathematically speaking, bow-ties evolve when the rank of the input-output matrix describing the evolutionary goal is deficient. The maximal compression possible (the rank of the goal determines the size of the narrowest part of the network-that is the bow-tie. A further requirement is that a process is active to reduce the number of links in the network, such as product-rule mutations, otherwise a non-bow-tie solution is found in the evolutionary simulations. This offers a mechanism to understand a common architectural principle of biological systems, and a way to quantitate the effective rank of the goals under which they evolved.

Spin and pseudospin symmetric Dirac particles in the field of Tietz—Hua potential including Coulomb tensor interaction

International Nuclear Information System (INIS)

Ikhdair, Sameer M.; Hamzavi, Majid

2013-01-01

Approximate analytical solutions of the Dirac equation for Tietz—Hua (TH) potential including Coulomb-like tensor (CLT) potential with arbitrary spin—orbit quantum number κ are obtained within the Pekeris approximation scheme to deal with the spin—orbit coupling terms κ(κ ± 1)r −2 . Under the exact spin and pseudospin symmetric limitation, bound state energy eigenvalues and associated unnormalized two-component wave functions of the Dirac particle in the field of both attractive and repulsive TH potential with tensor potential are found using the parametric Nikiforov—Uvarov (NU) method. The cases of the Morse oscillator with tensor potential, the generalized Morse oscillator with tensor potential, and the non-relativistic limits have been investigated. (general)

Longitudinal analysis of large social networks: estimating the effect of health traits on changes in friendship ties.

Science.gov (United States)

O'Malley, A James; Christakis, Nicholas A

2011-04-30

We develop novel mixed effects models to examine the role of health traits on the status of peoples' close friendship nominations in the Framingham Heart Study. The health traits considered are both mutable (body mass index (BMI), smoking, blood pressure, body proportion, muscularity, and depression) and, for comparison, basically immutable (height, birth order, personality type, only child, and handedness); and the traits have varying degrees of observability. We test the hypotheses that existing ties (i.e. close friendship nominations) are more likely to dissolve between people with dissimilar (mutable and observable) health traits whereas new ties are more likely to form between those with similar (mutable and observable) traits while controlling for persons' age, gender, geographic separation, and education. The mixed effects models contain random effects for both the nominator (ego) and nominated (alter) persons in a tie to account for the fact that people were involved in multiple relationships and contributed observations at multiple exams. Results for BMI support the hypotheses that people of similar BMI are less likely to dissolve existing ties and more likely to form ties, while smoker to non-smoker ties were the least likely to dissolve and smoker to smoker ties were the most likely to form. We also validated previously known findings regarding homophily on age and gender, and found evidence that homophily also depends upon geographic separation. Copyright © 2011 John Wiley & Sons, Ltd.

The power of indirect social ties

OpenAIRE

Zuo, Xiang; Blackburn, Jeremy; Kourtellis, Nicolas; Skvoretz, John; Iamnitchi, Adriana

2014-01-01

While direct social ties have been intensely studied in the context of computer-mediated social networks, indirect ties (e.g., friends of friends) have seen little attention. Yet in real life, we often rely on friends of our friends for recommendations (of good doctors, good schools, or good babysitters), for introduction to a new job opportunity, and for many other occasional needs. In this work we attempt to 1) quantify the strength of indirect social ties, 2) validate it, and 3) empiricall...

Risk Analysis on Leakage Failure of Natural Gas Pipelines by Fuzzy Bayesian Network with a Bow-Tie Model

OpenAIRE

Shan, Xian; Liu, Kang; Sun, Pei-Liang

2017-01-01

Pipeline is the major mode of natural gas transportation. Leakage of natural gas pipelines may cause explosions and fires, resulting in casualties, environmental damage, and material loss. Efficient risk analysis is of great significance for preventing and mitigating such potential accidents. The objective of this study is to present a practical risk assessment method based on Bow-tie model and Bayesian network for risk analysis of natural gas pipeline leakage. Firstly, identify the potential...

Religious and Non-religious Activity Engagement as Assets in Promoting Social Ties Throughout University: The Role of Emotion Regulation.

Science.gov (United States)

Semplonius, Thalia; Good, Marie; Willoughby, Teena

2015-08-01

Emerging adulthood is a time of many changes. For example, one change that occurs for a subset of emerging adults is leaving home and starting university. Importantly, the creation of social ties can aid in promoting positive adjustment during university. This study investigated whether involvement in religious activities promotes social ties among university students directly and/or indirectly through emotion regulation. Importantly, involvement in religious activities may promote self-regulatory skills, and the ability to effectively regulate emotions can aid in navigating social interactions. To rule out potentially important confounding variables, spirituality and involvement in non-religious clubs were statistically controlled in all analyses. The participants included 1,132 university students (70.5 % female) from a university in Ontario, Canada who were surveyed each year over a period of 3 years. The results indicated that involvement in religious activities indirectly predicted more social ties over time through emotion regulation. Spirituality did not predict social ties or emotion regulation. Furthermore, non-religious clubs directly predicted more social ties over time. Thus, although involvement in religious and non-religious activities both predicted more social ties in a university setting over time, the mechanism by which these activities promote social ties differed.

Differentiating weak ties and strong ties among external sources of influences for enterprise resource planning (ERP) adoption

Science.gov (United States)

Aubert, Benoit; Léger, Pierre-Majorique; Larocque, Denis

2012-05-01

Enterprise resource planning (ERP) systems represent a major IT adoption decision. ERP adoption decisions, in the chemicals and allied products sectors, were examined between 1994 and 2005. Networks of strong ties and weak ties partners are investigated. Results show that neighbouring companies linked with strong ties can have an influence on organisations making such adoption decision. Past decisions made by major trading partners have a significant influence on the decision to adopt an ERP system for a given organisation. This reflects the complex nature of the knowledge required for such adoption.

A comprehensive investigation on static and dynamic friction coefficients of wheat grain with the adoption of statistical analysis.

Science.gov (United States)

Shafaei, S M; Kamgar, S

2017-07-01

This paper deals with studying and modeling static friction coefficient (SFC) and dynamic friction coefficient (DFC) of wheat grain as affected by several treatments. Significance of single effect (SE) and dual interaction effect (DIE) of treatments (moisture content and contact surface) on SFC and, SE, DIE, and triple interaction effect (TIE) of treatments (moisture content, contact surface and sliding velocity) on DFC were determined using statistical analysis methods. Multiple linear regression (MLR) modeling was employed to predict SFC and DFC on different contact surfaces. Predictive ability of developed MLR models was evaluated using some statistical parameters (coefficient of determination ( R 2 ), root mean square error (RMSE), and mean relative deviation modulus (MRDM)). Results indicated that significant increasing DIE of treatments on SFC was 3.2 and 3 times greater than significant increasing SE of moisture content and contact surface, respectively. In case of DFC, the significant increasing TIE of treatments was 8.8, 3.7, and 8.9 times greater than SE of moisture content, contact surface, and sliding velocity, respectively. It was also found that the SE of contact surface on SFC was 1.1 times greater than that of moisture content and the SE of contact surface on DFC was 2.4 times greater than that of moisture content or sliding velocity. According to the reasonable average of statistical parameters ( R 2  = 0.955, RMSE = 0.01788 and MRDM = 3.152%), the SFC and DFC could be successfully predicted by suggested MLR models. Practically, it is recommended to apply the models for direct prediction of SFC and DFC, respective to each contact surface, based on moisture content and sliding velocity.

Vínculos organizacionais Organizational ties

Directory of Open Access Journals (Sweden)

Gustavo Garcez Kramer

2007-02-01

Full Text Available Este artigo é um estudo de caso único, realizado junto a uma organização pública municipal de Curitiba, e tem como objetivo investigar e compreender os vínculos organizacionais. O estudo dos vínculos é feito por meio dos seus elementos constitutivos: a identificação, o sentimento de pertença, a cooperação, a participação, a criação de inimigos, a idealização, o reconhecimento e valorização dos indivíduos, a solidariedade, a integração, o crescimento e desenvolvimento pessoal e profissional e a autonomia. Foram utilizados, como instrumentos de coleta, questionário fechado e análise documental. O resultado dessa pesquisa é a caracterização dos elementos que são importantes na formação e manutenção dos vínculos e, conseqüentemente, para o comprometimento dos empregados com os objetivos, políticas, problemas, desempenho e resultados da organização.This article presents a unique case study of the organizational ties in a public municipal organization in the city of Curitiba, Brazil. The ties are studied through their constitutive elements: identification, sense of belonging, cooperation, participation, creation of enemies, idealization, recognition and appreciation of individuals, solidarity, integration, professional and personal development and growth, and autonomy. Documental analysis and closed questionnaires were used for data collection. The research resulted in the characterization of the elements that are important in making and keeping ties, and consequently committing employees to the organization's objectives, policies, problems, performance and results.

It's the recipient that counts: spending money on strong social ties leads to greater happiness than spending on weak social ties.

Science.gov (United States)

Aknin, Lara B; Sandstrom, Gillian M; Dunn, Elizabeth W; Norton, Michael I

2011-02-10

Previous research has shown that spending money on others (prosocial spending) increases happiness. But, do the happiness gains depend on who the money is spent on? Sociologists have distinguished between strong ties with close friends and family and weak ties--relationships characterized by less frequent contact, lower emotional intensity, and limited intimacy. We randomly assigned participants to reflect on a time when they spent money on either a strong social tie or a weak social tie. Participants reported higher levels of positive affect after recalling a time they spent on a strong tie versus a weak tie. The level of intimacy in the relationship was more important than the type of relationship; there was no significant difference in positive affect after recalling spending money on a family member instead of a friend. These results add to the growing literature examining the factors that moderate the link between prosocial behaviour and happiness.

Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas.

Science.gov (United States)

Cortes-Santiago, Nahir; Hossain, Mohammad B; Gabrusiewicz, Konrad; Fan, Xuejun; Gumin, Joy; Marini, Frank C; Alonso, Marta M; Lang, Frederick; Yung, W K; Fueyo, Juan; Gomez-Manzano, Candelaria

2016-03-29

Glioblastoma recurrence after treatment with the anti-vascular endothelial growth factor (VEGF) agent bevacizumab is characterized by a highly infiltrative and malignant behavior that renders surgical excision and chemotherapy ineffective. Our group has previously reported that Tie2-expressing monocytes (TEMs) are aberrantly present at the tumor/normal brain interface after anti-VEGF therapies and their significant role in the invasive outgrowth of these tumors. Here, we aimed to further understand the mechanisms leading to this pro-invasive tumor microenvironment. Examination of a U87MG xenogeneic glioma model and a GL261 murine syngeneic model showed increased tumor expression of angiopoietin 2 (Ang2), a natural ligand of Tie2, after anti-angiogenesis therapies targeting VEGF or VEGF receptor (VEGFR), as assessed by immunohistochemical analysis, immunofluorescence analysis, and enzyme-linked immunosorbent assays of tumor lysates. Migration and gelatinolytic assays showed that Ang2 acts as both a chemoattractant of TEMs and an enhancing signal for their tumor-remodeling properties. Accordingly, in vivo transduction of Ang2 into intracranial gliomas increased recruitment of TEMs into the tumor. To reduce invasive tumor outgrowth after anti-angiogenesis therapy, we targeted the Ang-Tie2 axis using a Tie2 decoy receptor. Using syngeneic models, we observed that overexpression of soluble Tie2 within the tumor prevented the recruitment of TEMs to the tumor and the development of invasion after anti-angiogenesis treatment. Taken together, these data indicate an active role for the Ang2-Tie2 pathway in invasive glioma recurrence after anti-angiogenesis treatment and provide a rationale for testing the combined targeting of VEGF and Ang-Tie2 pathways in patients with glioblastoma.

An LLCL Power Filter for Single-Phase Grid-Tied Inverter

DEFF Research Database (Denmark)

Wu, Weimin; He, Yuanbin; Blaabjerg, Frede

2012-01-01

This paper presents a new topology of higher order power filter for grid-tied voltage-source inverters, named the LLCL filter, which inserts a small inductor in the branch loop of the capacitor in the traditional LCL filter to compose a series resonant circuit at the switching frequency. Particul......This paper presents a new topology of higher order power filter for grid-tied voltage-source inverters, named the LLCL filter, which inserts a small inductor in the branch loop of the capacitor in the traditional LCL filter to compose a series resonant circuit at the switching frequency...... to the inverter system control. The parameter design criteria of the proposed LLCL filter is also introduced. The comparative analysis and discussions regarding the traditional LCL filter and the proposed LLCL filter have been presented and evaluated through experiment on a 1.8-kW-single-phase grid-tied inverter...

The Tie retraction syndrome.

Science.gov (United States)

Geerling, Gerd; Neppert, Birte; Hemmant, Bridget

2012-12-01

Tissue retraction is implicated in the pathogenesis of various ophthalmic disorders. Here we describe the clinical characteristics, epidemiology and pathophysiology of a form of retraction syndrome which - to the best of our knowledge - has not been reported in the ophthalmic literature so far. We have termed this condition - consisting of a slowly progressive pseudovertical shortening of tie length due to a horizontal extension of girth length - the "Tie retraction syndrome" (TRS). Other pathognomonic features include an increased tie tip to belt buckle distance and a prolapse of the subumbilical fat pad (SUFP). The syndrome has a clear male to female preponderance and shows an increasing incidence with age and income before tax. Based on a newly proposed grading scheme we discuss and illustrate the diagnosis as well as the medical and surgical management options of this abundant, but often undiagnosed condition. The authors have no explanation for the apparent lack of awareness for this widely preponderant syndrome and its severe cosmetically disfiguring potential. We thus would like to invite all fellow colleagues with expertise in the field to comment or present their views.

Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs

DEFF Research Database (Denmark)

Teilmann, Stefan C; Christensen, Søren T

2005-01-01

Blood vessel homeostasis and endothelial cell survival depend on proper signalling through angiopoietin receptors such as the receptor tyrosine kinases Tie-1 and Tie-2. We have studied the presence and subcellular localization of these receptors in murine female reproductive organs using confocal...... organs play a novel and important sensory role in relaying physiochemical changes from the extracellular environment to epithelial cells of the oviduct, the ovary and extra-ovarian tissues.......Blood vessel homeostasis and endothelial cell survival depend on proper signalling through angiopoietin receptors such as the receptor tyrosine kinases Tie-1 and Tie-2. We have studied the presence and subcellular localization of these receptors in murine female reproductive organs using confocal...

It's the recipient that counts: spending money on strong social ties leads to greater happiness than spending on weak social ties.

Directory of Open Access Journals (Sweden)

Lara B Aknin

Full Text Available Previous research has shown that spending money on others (prosocial spending increases happiness. But, do the happiness gains depend on who the money is spent on? Sociologists have distinguished between strong ties with close friends and family and weak ties--relationships characterized by less frequent contact, lower emotional intensity, and limited intimacy. We randomly assigned participants to reflect on a time when they spent money on either a strong social tie or a weak social tie. Participants reported higher levels of positive affect after recalling a time they spent on a strong tie versus a weak tie. The level of intimacy in the relationship was more important than the type of relationship; there was no significant difference in positive affect after recalling spending money on a family member instead of a friend. These results add to the growing literature examining the factors that moderate the link between prosocial behaviour and happiness.

Family ties and health cross-nationally: the contextualizing role of familistic culture and public pension spending in Europe.

Science.gov (United States)

Mair, Christine A

2013-11-01

Although previous research theorizes that cross-national variation in the relationship between family ties and health is due to nation-level differences in culture and policy/economics, no study has examined this theorization empirically. Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE) and the Organization for Economic Co-operation and Development (OECD), this study uses multilevel modeling to analyze individual-, nation-, and cross-level effects for 30,291 older adults in 14 nations. Family ties to spouses/partners and parents are associated with better health, but ties to coresident children are associated with poorer health in certain contexts. Familistic culture and public pension spending have a weak but statistically significant moderating effect on the relationship between intergenerational family ties and health. This article underscores the complexity of family and highlights the need for continued theorization and measurement at the nation level to promote older adults' health in diverse contexts.

Family Ties and Health Cross-Nationally: The Contextualizing Role of Familistic Culture and Public Pension Spending in Europe

Science.gov (United States)

2013-01-01

Objectives. Although previous research theorizes that cross-national variation in the relationship between family ties and health is due to nation-level differences in culture and policy/economics, no study has examined this theorization empirically. Method. Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE) and the Organization for Economic Co-operation and Development (OECD), this study uses multilevel modeling to analyze individual-, nation-, and cross-level effects for 30,291 older adults in 14 nations. Results. Family ties to spouses/partners and parents are associated with better health, but ties to coresident children are associated with poorer health in certain contexts. Familistic culture and public pension spending have a weak but statistically significant moderating effect on the relationship between intergenerational family ties and health. Discussion. This article underscores the complexity of family and highlights the need for continued theorization and measurement at the nation level to promote older adults’ health in diverse contexts. PMID:24043356

The ties that bind: Ingroup ties are linked with diminished inflammatory immune responses and fewer mental health symptoms through less rumination.

Science.gov (United States)

Ysseldyk, Renate; McQuaid, Robyn J; McInnis, Opal A; Anisman, Hymie; Matheson, Kimberly

2018-01-01

The present research explored whether components of social identity, namely ingroup ties, affect, and centrality, were differentially linked to mental health and inflammatory immune responses, and whether rumination mediated those relations. Study 1 (N = 138) indicated that stronger ingroup ties were associated with fewer mental health (depressive and post-traumatic stress) symptoms; those relations were mediated by the tendency for individuals with strong ties to rely less on ruminative coping to deal with a stressful life event. Study 2 (N = 54) demonstrated that ingroup ties were negatively associated with depressive symptoms, dispositional rumination, as well as stress-linked inflammatory elements at the physiological level. Consistent associations for centrality and ingroup affect were absent, suggesting that ingroup ties may have unique health benefits.

Risk Analysis on Leakage Failure of Natural Gas Pipelines by Fuzzy Bayesian Network with a Bow-Tie Model

Directory of Open Access Journals (Sweden)

Xian Shan

2017-01-01

Full Text Available Pipeline is the major mode of natural gas transportation. Leakage of natural gas pipelines may cause explosions and fires, resulting in casualties, environmental damage, and material loss. Efficient risk analysis is of great significance for preventing and mitigating such potential accidents. The objective of this study is to present a practical risk assessment method based on Bow-tie model and Bayesian network for risk analysis of natural gas pipeline leakage. Firstly, identify the potential risk factors and consequences of the failure. Then construct the Bow-tie model, use the quantitative analysis of Bayesian network to find the weak links in the system, and make a prediction of the control measures to reduce the rate of the accident. In order to deal with the uncertainty existing in the determination of the probability of basic events, fuzzy logic method is used. Results of a case study show that the most likely causes of natural gas pipeline leakage occurrence are parties ignore signage, implicit signage, overload, and design defect of auxiliaries. Once the leakage occurs, it is most likely to result in fire and explosion. Corresponding measures taken on time will reduce the disaster degree of accidents to the least extent.

Recovery From Radiation-induced Bone Marrow Damage by HSP25 Through Tie2 Signaling

Energy Technology Data Exchange (ETDEWEB)

Lee, Hae-June [Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kwon, Hee-Chung [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Chung, Hee-Yong [College of Medicine, Hanyang University, Seoul (Korea, Republic of); Lee, Yoon-Jin [Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Yun-Sil, E-mail: yslee0425@ewha.ac.kr [College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Woman' s University, Seoul (Korea, Republic of)

2012-09-01

Purpose: Whole-body radiation therapy can cause severe injury to the hematopoietic system, and therefore it is necessary to identify a novel strategy for overcoming this injury. Methods and Materials: Mice were irradiated with 4.5 Gy after heat shock protein 25 (HSP25) gene transfer using an adenoviral vector. Then, peripheral blood cell counts, histopathological analysis, and Western blotting on bone marrow (BM) cells were performed. The interaction of HSP25 with Tie2 was investigated with mouse OP9 and human BM-derived mesenchymal stem cells to determine the mechanism of HSP25 in the hematopoietic system. Results: HSP25 transfer increased BM regeneration and reduced apoptosis following whole-body exposure to ionizing radiation (IR). The decrease in Tie2 protein expression that followed irradiation of the BM was blocked by HSP25 transfer, and Tie2-positive cells were more abundant among the BM cells of HSP25-transferred mice, even after IR exposure. Following systemic RNA interference of Tie2 before IR, HSP25-mediated radioprotective effects were partially blocked in both mice and cell line systems. Stability of Tie2 was increased by HSP25, a response mediated by the interaction of HSP25 with Tie2. IR-induced tyrosine phosphorylation of Tie2 was augmented by HSP25 overexpression; downstream events in the Tie2 signaling pathway, including phosphorylation of AKT and EKR1/2, were also activated. Conclusions: HSP25 protects against radiation-induced BM damage by interacting with and stabilizing Tie2. This may be a novel strategy for HSP25-mediated radioprotection in BM.

Do recruitment ties affect wages? An analysis using matched employer-employee data from Vietnam

DEFF Research Database (Denmark)

Larsen, Anna Folke; Rand, John; Torm, Nina Elisabeth

2011-01-01

This paper examines the extent to which recruitment ties affect individual wage outcomes in small and medium scale manufacturing firms. Based on a unique matched employer–employee dataset from Vietnam the authors find that there is a significant positive wage premium associated with obtaining a job...... through an informal contact, when controlling for standard determinants of wage compensation. Moreover, they show that the mechanism through which informal contacts affect wages depends on the type of recruitment tie used. The findings are robust across location, firm size categories, and different worker...

Senior Managers’ Network Tie Use

DEFF Research Database (Denmark)

Zarzecka, Olga; Villeseche, Florence

While the importance or even necessity to build and maintain resourceful social networks appears as a forthright fact, there is still a lack of certainty as to who benefits from the resources that can be accessed through senior managers’ networks, and under what conditions. In this paper, we...... contribute to answering this puzzle with a sample constituted of senior managers from Denmark and their network ties, and investigate both economic and sociological conditions of senior managers’ tie use. Our results show that the greater the distance between aspiration level and actual firm performance......, the more likely it is that senior managers will use their network ties to access resources that benefit chiefly the individual rather than the organization. In addition, we demonstrate that this rapport is moderated by senior managers’ social identity as a member of the corporate elite, so that a strong...

Beginning statistics with data analysis

CERN Document Server

Mosteller, Frederick; Rourke, Robert EK

2013-01-01

This introduction to the world of statistics covers exploratory data analysis, methods for collecting data, formal statistical inference, and techniques of regression and analysis of variance. 1983 edition.

Statistical Models for Social Networks

NARCIS (Netherlands)

Snijders, Tom A. B.; Cook, KS; Massey, DS

2011-01-01

Statistical models for social networks as dependent variables must represent the typical network dependencies between tie variables such as reciprocity, homophily, transitivity, etc. This review first treats models for single (cross-sectionally observed) networks and then for network dynamics. For

Hanging Together, Together Hung? Career Implications of Interpersonal Ties Between CEOs and Top Managers

Directory of Open Access Journals (Sweden)

Stefan Hilger

2013-05-01

Full Text Available Is it good or bad for senior executives to have strong interpersonal ties to the CEO? We argue that a strong relationship with the CEO raises the likelihood that a top manager stays in office or makes an upward career move when the CEO leaves office voluntarily. At the same time, such interpersonal ties also reinforce the negative spillover effects of a dismissal of the CEO on the career prospects of the manager concerned. Our empirical analysis lends support to both arguments. We contribute to managerial succession research by underlining the ambivalence of interpersonal ties within top management teams.

FEATURES OF THE APPLICATION OF STATISTICAL INDICATORS OF SCHEDULED FLIGHTS OF AIRCRAFT

Directory of Open Access Journals (Sweden)

2016-01-01

Full Text Available Тhe possibilities of increasing the effectiveness of management of safety of regular aircraft operations on the basis of systematic approach, under normal operating conditions are considered. These new opportunities within the airline are based on Flight Safety Management System integration with quality management system. So far, however, these possibili- ties are practically not implemented due to the limited application of statistical methods. A necessary condition for the implementation of the proposed approach is the use of statistical flight data results of the quality control flight. The proper- ties and peculiarities of application of statistical indicators of flight parameters during the monitoring of flight data are analyzed. It is shown that the main statistical indicators of the controlled process are averages and variations. The features of the application of theoretical models of mathematical statistics in the analysis of flight information are indicated. It is noted that in practice the theoretical models often do not fit into the framework of its application because of the violation of the initial assumptions. Recommendations are given for the integrated use of statistical indicators of the current quality control of flights. Ultimately, the article concludes that the capabilities of the proposed approach allows on the basis of knowledge about the dynamics of statistical indicators of controlled flight process to identify hazards and develop safety indicators for the new information based on data flight operation aircraft.

Airborne Microorganisms in Tie-stall Dairy Barns from Brasov County

Directory of Open Access Journals (Sweden)

Silvana Popescu

2011-05-01

Full Text Available The aim of this study was the assessment of the airborne microorganisms in tie-stall dairy cattle barns, through determination of the total number of bacteria (mesophilic bacteria, staphylococci, streptococci and gram-negative bacteria and fungi. We investigated 8 dairy cattle barns with tie-stalls in Brasov County during the winter of 2009. The mean numbers of bacteria and fungi in the morning and in the evening were: 1.02 °— 105 - 1.26 °— 105 CFU/m3 for mesophilic bacteria, 5.34 °— 104 - 5.91 °— 104 CFU/m3 for staphylococci, 2.93 °— 104 - 3.60 °— 104 CFU/m3 for streptococci, 2.17 °— 103 - 3.48 °— 103 CFU/m3 for gram-negative bacteria and 1.54 °— 104 - 2.75 °— 104 CFU/m3 for fungi. In the investigated cattle houses staphylococci represented 52.35 – 46.90%, streptococci were 28.73 – 28.57%, and the gram-negative bacteria were 2.13 – 2.76% within the overall number of mesophilic bacteria. The numbers of bacteria and fungi were slightly elevated in the evening comparative to the morning, but the differences were statistically insignificant (p>0.05. The great numbers of bacteria and fungi in the air of dairy cattle tie-stall barns indicate an elevated risk of disease for animals and human workers.

The emergence of cooperation in tie strength models

International Nuclear Information System (INIS)

Xu, Bo; Yue, Yunpeng

2016-01-01

In this paper, we propose a tie strength model to explain the emergence of cooperation in spatial prisoner's dilemma games, assuming that cooperators preferentially allocate their investments to friends with strong ties. Two types of prisoner's dilemma models are examined in this study: the traditional two-strategy model considering only cooperators and defectors; the expanded three-strategy model consisting cooperators, defectors and extortioners. The results show that tie strength model contributes to the promotion of cooperation in both types of prisoner's dilemma games. However, we point out that the influence of the investment preference is quite different in the two prisoner's dilemma game settings. In the two-strategy prisoner's dilemma game, only small preference contributes to the promotion of cooperation. Once this preference exceeds a critical value, cooperation will be prohibited. We explain this phenomenon by arguing that extremely strong investment preference undermines the ability of cooperative clusters to resist defectors. Moreover, we extend the analysis into the three-strategy case and discover that the catalytic effect of extortioners can eliminate this first up and then down trend in the two-strategy model. The equilibrium fraction of cooperators is always positively correlated to the level of investment preference in three-strategy models.

Research design and statistical analysis

CERN Document Server

Myers, Jerome L; Lorch Jr, Robert F

2013-01-01

Research Design and Statistical Analysis provides comprehensive coverage of the design principles and statistical concepts necessary to make sense of real data.  The book's goal is to provide a strong conceptual foundation to enable readers to generalize concepts to new research situations.  Emphasis is placed on the underlying logic and assumptions of the analysis and what it tells the researcher, the limitations of the analysis, and the consequences of violating assumptions.  Sampling, design efficiency, and statistical models are emphasized throughout. As per APA recommendations

FEATURES OF DESIGN OF TIED-ARCH BRIDGES WITH FLEXIBLE INCLINED SUSPENSION HANGERS

Directory of Open Access Journals (Sweden)

V. O. Samosvat

2017-10-01

Full Text Available Purpose. Investigation and analysis of the hanger arrangement and the structural stability of a Network arch bridge – a tied-arch bridge with inclined hangers that cross each other at least twice. It is also necessary to make a comparative analysis with other types of hanger arrangements. Methodology. The authors in their research investigated a large number of parameters to determine their influence in the force distribution in the arch. Eventually they determined optimal values for all parameters. These optimal values allowed developing a design guide that leads to optimal arch design. When solving this problem, the authors used three-dimensional finite element models and the objective was to determine the most suitable solution for a road bridge, with a span of 100 meters, consisting of two inclined steel arches, located on a road with two traffic lanes, subjected to medium traffic. The virtual prototype of the model is performed by finite element simulator Midas Civil. Findings. In this study, for the bridge deck, a concrete tie appears to be the best solution considering the structural behavior of network arches, but economic advantages caused by easier erection may lead to steel or a composite bridge deck as better alternatives. Design requirements and local conditions of each particular bridge project will decide the most economic deck design.Originality. To ensure passenger comfort and the stability and continuity of the track, deformations of bridges are constricted. A network arch is a stiff structure with small deflections and therefore suitable to comply with such demands even for high speed railway traffic.
A network arch bridge with a concrete tie usually saves more than half the steel required for tied arches with vertical hangers and concrete ties. Practical value. Following the study design advice given in this article leads to savings of about 60 % of structural steel compared with conventional tied arch bridges with

Tyrosine phosphorylation of Grb14 by Tie2

Directory of Open Access Journals (Sweden)

Dumont Daniel J

2010-10-01

Full Text Available Abstract Background Growth factor receptor bound (Grb proteins 7, 10 and 14 are a family of structurally related multi-domain adaptor proteins involved in a variety of biological processes. Grb7, 10 and 14 are known to become serine and/or threonine phosphorylated in response to growth factor (GF stimulation. Grb7 and 10 have also been shown to become tyrosine phosphorylated under certain conditions. Under experimental conditions Grb7 is tyrosine phosphorylated by the Tie2/Tie-2/Tek angiogenic receptor tyrosine kinase (RTK. Furthermore, Grb14 has also been shown to interact with Tie2, however tyrosine phosphorylation of this Grb family member has yet to be reported. Results Here we report for the first time tyrosine phosphorylation of Grb14. This phosphorylation requires a kinase competent Tie2 as well as intact tyrosines 1100 and 1106 (Y1100 and Y1106 on the receptor. Furthermore, a complete SH2 domain on Grb14 is required for Grb14 tyrosine phosphorylation by Tie2. Grb14 was also able to become tyrosine phosphorylated in primary endothelial cells when treated with a soluble and potent variant of the Tie2 ligand, cartilage oligomeric matrix protein (COMP Ang1. Conclusion Our results show that Grb14, like its family members Grb7 and Grb10, is able to be tyrosine phosphorylated. Furthermore, our data indicate a role for Grb14 in endothelial signaling downstream of the Tie2 receptor.

Redoable Tie-Over Dressing Using Multiple Loop Silk Threads

Directory of Open Access Journals (Sweden)

Hyeon Jong Jo

2013-05-01

Full Text Available After skin grafting, to prevent hematoma or seroma collection at the graft site, a tie-over dressing has been commonly used. However, although the conventional tie-over dressing by suture is a useful method for securing a graft site, refixation is difficult when repeated tie-over dressing is needed. Therefore, we recommend a redoable tie-over dressing technique with multiple loops threads and connecting silk threads. After the raw surface of each of our cases was covered with a skin graft, multiple loop silk thread attached with nylon at the skin graft margin. We applied the ointment gauze and wet cotton/fluffy gauze over the skin graft, then fixed the dressing by connecting cross-counter multiple loop thread with connecting silk threads. When we opened the tie-over dressing by cutting the connecting silk threads, we repeated the tie-over dressing with the same method. The skin graft was taken successfully without hematoma or seroma collection or any other complications. In conclusion, we report a novel tie-over dressing enabling simple fixation of the dressing to maintain proper tension for wounds that require repetitive fixation. Further, with this reliable method, the skin grafts were well taken.

Artifacts in magnetic spirals retrieved by transport of intensity equation (TIE)

Science.gov (United States)

Cui, J.; Yao, Y.; Shen, X.; Wang, Y. G.; Yu, R. C.

2018-05-01

The artifacts in the magnetic structures reconstructed from Lorentz transmission electron microscopy (LTEM) images with TIE method have been analyzed in detail. The processing for the simulated images of Bloch and Neel spirals indicated that the improper parameters in TIE may overestimate the high frequency information and induce some false features in the retrieved images. The specimen tilting will further complicate the analysis of the images because the LTEM image contrast is not the result of the magnetization distribution within the specimen but the integral projection pattern of the magnetic induction filling the entire space including the specimen.

Statistics and Biomedical Informatics in Forensic Sciences

Czech Academy of Sciences Publication Activity Database

Zvárová, Jana

2009-01-01

Roč. 20, č. 6 (2009), s. 743-750 ISSN 1180-4009. [TIES 2007. Annual Meeting of the International Environmental Society /18./. Mikulov, 16.08.2007-20.08.2007] Institutional research plan: CEZ:AV0Z10300504 Keywords : biomedical informatics * biomedical statistics * genetic information * forensic dentistry Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 1.000, year: 2009

Statistical data analysis handbook

National Research Council Canada - National Science Library

Wall, Francis J

1986-01-01

It must be emphasized that this is not a text book on statistics. Instead it is a working tool that presents data analysis in clear, concise terms which can be readily understood even by those without formal training in statistics...

Long-Term Evolution of Email Networks: Statistical Regularities, Predictability and Stability of Social Behaviors.

Science.gov (United States)

Godoy-Lorite, Antonia; Guimerà, Roger; Sales-Pardo, Marta

2016-01-01

In social networks, individuals constantly drop ties and replace them by new ones in a highly unpredictable fashion. This highly dynamical nature of social ties has important implications for processes such as the spread of information or of epidemics. Several studies have demonstrated the influence of a number of factors on the intricate microscopic process of tie replacement, but the macroscopic long-term effects of such changes remain largely unexplored. Here we investigate whether, despite the inherent randomness at the microscopic level, there are macroscopic statistical regularities in the long-term evolution of social networks. In particular, we analyze the email network of a large organization with over 1,000 individuals throughout four consecutive years. We find that, although the evolution of individual ties is highly unpredictable, the macro-evolution of social communication networks follows well-defined statistical patterns, characterized by exponentially decaying log-variations of the weight of social ties and of individuals' social strength. At the same time, we find that individuals have social signatures and communication strategies that are remarkably stable over the scale of several years.

Relevant ties matter

DEFF Research Database (Denmark)

Larsen, Christian Albrekt; Pedersen, Jacob; Mouw, Ted

What is the effect of social networks on labor market outcomes? The tradition following Grannovetter claims that social ties have a positive effect on wages, job prestige and job satisfaction. Although a number of studies have found positive correlations between friendship characteristics and lab...

Do recruitment ties affect wages?

DEFF Research Database (Denmark)

Larsen, Anna Folke; Rand, John; Torm, Nina Elisabeth

This paper examines the extent to which recruitment ties affect individual wage outcomes in small and medium scale manufacturing firms. Based on a unique matched employer-employee dataset from Vietnam we find that there is a significant positive wage premium associated with obtaining a job through...... an informal contact, when controlling for standard determinants of wage compensation. Moreover, we show that the mechanism through which informal contacts affect wages depends on the type of recruitment tie used. The findings are robust across location, firm size categories and different worker types....

Family Ties and Civic Virtues

DEFF Research Database (Denmark)

Ljunge, Jan Martin

I establish a positive relationship between family ties and civic virtues, as captured by disapproval of tax and benefit cheating, corruption, and a range of other dimensions of exploiting others for personal gain. I find that family ties are a complement to social capital, using within country...... evidence from 83 nations and data on second generation immigrants in 29 countries with ancestry in 85 nations. Strong families cultivate universalist values and produce more civic and altruistic individuals. The results provide a constructive role for families in promoting family values that support...

Tie-breaking in games of perfect information

DEFF Research Database (Denmark)

Tranæs, Torben

1998-01-01

The paper suggests that ties in an extensive form game have strategic implications if they represent credible threats or promises. We consider a subset of subgame-perfect Nash equilibria obtained by breaking ties according to their strategic implications, and show that the subset is nonempty for ...

Grid-Tied Photovoltaic Power System

Science.gov (United States)

Eichenberg, Dennis J.

2011-01-01

A grid-tied photovoltaic (PV) power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. Operating costs of a PV power system are low compared to conventional power technologies. This method can displace the highest-cost electricity during times of peak demand in most climatic regions, and thus reduce grid loading. Net metering is often used, in which independent power producers such as PV power systems are connected to the utility grid via the customers main service panels and meters. When the PV power system is generating more power than required at that location, the excess power is provided to the utility grid. The customer pays the net of the power purchased when the on-site power demand is greater than the onsite power production, and the excess power is returned to the utility grid. Power generated by the PV system reduces utility demand, and the surplus power aids the community. Modern PV panels are readily available, reliable, efficient, and economical, with a life expectancy of at least 25 years. Modern electronics have been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy equal to the modern PV panels. The grid-tied PV power system was successfully designed and developed, and this served to validate the basic principles developed, and the theoretical work that was performed. Grid-tied PV power systems are reliable, maintenance- free, long-life power systems, and are of significant value to NASA and the community. Of particular value are the analytical tools and capabilities that have been successfully developed. Performance predictions can be made confidently for grid-tied PV systems of various scales. The work was done under the NASA Hybrid Power Management (HPM

The life-extension and upgrade program of the Tsing Hua Open-pool Reactor (THOR) and its research prospectives

International Nuclear Information System (INIS)

Kai, J.-J.

1992-01-01

The Tsing Hua Open-Pool Reactor (THOR) has been operated for thirty years. It is the regulations of the ROCAEC that any reactor shall be decommissioned after forty-year operation since the first fuel loading. Therefore, for extending the lifetime of THOR, it is necessary to have a life-extension program to be approved by the ROCAEC and also completed by the year of 1997. At the same time, for proceeding new research purposes, it is planed to upgrade the thermal power of THOR from 1 Wth up to 3 Wth and hopefully to reach the maximum thermal neutron flux of 5x10 13 n/cm 2 .s and the fast flux close to that order. New research directions involve (a) boron-captured neutron cancer therapy (BNCT) (b) small-angle neutron scattering (SANS). (author)

A random-sum Wilcoxon statistic and its application to analysis of ROC and LROC data.

Science.gov (United States)

Tang, Liansheng Larry; Balakrishnan, N

2011-01-01

The Wilcoxon-Mann-Whitney statistic is commonly used for a distribution-free comparison of two groups. One requirement for its use is that the sample sizes of the two groups are fixed. This is violated in some of the applications such as medical imaging studies and diagnostic marker studies; in the former, the violation occurs since the number of correctly localized abnormal images is random, while in the latter the violation is due to some subjects not having observable measurements. For this reason, we propose here a random-sum Wilcoxon statistic for comparing two groups in the presence of ties, and derive its variance as well as its asymptotic distribution for large sample sizes. The proposed statistic includes the regular Wilcoxon rank-sum statistic. Finally, we apply the proposed statistic for summarizing location response operating characteristic data from a liver computed tomography study, and also for summarizing diagnostic accuracy of biomarker data.

Statistical Power in Meta-Analysis

Science.gov (United States)

Liu, Jin

2015-01-01

Statistical power is important in a meta-analysis study, although few studies have examined the performance of simulated power in meta-analysis. The purpose of this study is to inform researchers about statistical power estimation on two sample mean difference test under different situations: (1) the discrepancy between the analytical power and…

Network ties in the international opportunity recognition of family SMEs

OpenAIRE

Kontinen, Tanja; Ojala, Arto

2011-01-01

The importance of network ties is emphasized in the current literature on opportunity recognition. However, it is unclear how firms with limited bridging networks, such as family SMEs, recognize international opportunities through their network ties. In this case study we found that in gaining foreign market entry, those family SMEs that lack existing network ties recognize opportunities through weak ties formed in international exhibitions. The findings also indicate that rather than being p...

“Strength of Weak Ties,” Neighborhood Ethnic Heterogeneity, and Depressive Symptoms among Adults: A Multilevel Analysis of Korean General Social Survey (KGSS 2012

Directory of Open Access Journals (Sweden)

Harris Hyun-soo Kim

2017-06-01

Full Text Available A substantial body of research, based largely on North American and European contexts, demonstrates that social networks play a critical role in protecting and promoting mental, as well as physical, health. The purpose of this study is to examine how “weak” and “strong” network relations are differentially related to individual mental health (depressive symptoms based on a nationally representative sample of South Korean adults. Using multilevel analysis, the current research also investigates the extent to which contextual or neighborhood-level factors moderate the associations between depression and social network. Findings show that regular interaction with weaker ties (acquaintances, neighbors, coworkers, etc. are associated with better mental health. The number of strong ties (family members and friends, on the other hand, is not a significant predictor of psychological distress. In addition, a cross-level interaction term is observed: The negative relationship between weak ties and depressive symptoms is diminished in neighborhoods with more foreign-born residents or immigrants. General implications beyond the empirical case under investigation are discussed, as to why weak ties can be “strong” in relation to mental health and how this phenomenon can vary according to residential characteristics such as ethnic heterogeneity.

Automated Simultaneous Local Ties with GNSS and Robot Tacheometer

Science.gov (United States)

Kallio, Ulla; Lösler, Michael; Bergstrand, Sten; Haas, Rüdiger; Eschelbach, Cornelia

2016-12-01

We have used GPS-based local-tie measurements simultaneously with geo-VLBI observations since 2008 during every geodetic VLBI session at Metsähovi. This system uses gimbal-mounted GNSS antennas that are mounted on the reflector of the Metsähovi 14-m radio telescope. A similar system was installed in 2013 at the Onsala 20-m radio telescope and has been used for a large number of VLBI sessions, including, e.g., the 15-day-long CONT14 campaign. In order to verify the results of the two systems, we performed a dedicated measurement campaign in the framework of the SIB60 project, involving both Metsähovi and Onsala. During this campaign the local ties at the two stations were measured simultaneously during two VLBI sessions in August and September 2015 where both stations participated. The robot tacheometer monitoring system HEIMDALL was used for the automated classical monitoring of the telescopes at both stations. Moreover, additional local terrestrial measurements were performed several times to derive the full IVS-IGS local ties at both sites. The kinematic GPS measurements at the two stations were analyzed with two independently developed analysis programs. We present here the preparations of the campaign, the measurement process, and preliminary results.

Finite element analyses of continuous filament ties for masonry applications: final report for the Arquin Corporation

Energy Technology Data Exchange (ETDEWEB)

Quinones, Sr., Armando [Arquin Corporation, La Luz, NM (United States); Bibeau, Tiffany A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ho, Clifford Kuofei

2006-06-01

Finite-element analyses were performed to simulate the response of a hypothetical masonry shear wall with and without continuous filament ties to various lateral loads. The loads represented three different scenarios: (1) 100 mph wind, (2) explosive attack, and (3) an earthquake. In addition, a static loading analysis and cost comparison were performed to evaluate optimal materials and designs for the spacers affixed to the filaments. Results showed that polypropylene, ABS, and polyethylene (high density) were suitable materials for the spacers based on performance and cost, and the short T-spacer design was optimal based on its performance and functionality. Results of the shear-wall loading simulations revealed that simulated walls with the continuous filament ties yielded factors of safety that were at least ten times greater than those without the ties. In the explosive attack simulation (100 psi), the simulated wall without the ties failed (minimum factor of safety was less than one), but the simulated wall with the ties yielded a minimum factor of safety greater than one. Simulations of the walls subject to lateral loads caused by 100 mph winds (0.2 psi) and seismic events with a peak ground acceleration of 1 ''g'' (0.66 psi) yielded no failures with or without the ties. Simulations of wall displacement during the seismic scenarios showed that the wall with the ties resulted in a maximum displacement that was 20% less than the wall without the ties.

Statistical Power in Longitudinal Network Studies

NARCIS (Netherlands)

Stadtfeld, Christoph; Snijders, Tom A. B.; Steglich, Christian; van Duijn, Marijtje

2018-01-01

Longitudinal social network studies may easily suffer from a lack of statistical power. This is the case in particular for studies that simultaneously investigate change of network ties and change of nodal attributes. Such selection and influence studies have become increasingly popular due to the

Redoable Tie-Over Dressing Using Multiple Loop Silk Threads

Directory of Open Access Journals (Sweden)

Hyeon Jong Jo

2013-05-01

Full Text Available After skin grafting, to prevent hematoma or seroma collection at the graft site, a tie-over dressing has been commonly used. However, although the conventional tie-over dressing by suture is a useful method for securing a graft site, refixation is difficult when repeated tieover dressing is needed. Therefore, we recommend a redoable tie-over dressing technique with multiple loops threads and connecting silk threads. After the raw surface of each of our cases was covered with a skin graft, multiple loop silk thread attached with nylon at the skin graft margin. We applied the ointment gauze and wet cotton/fluffy gauze over the skin graft, then fixed the dressing by connecting cross-counter multiple loop thread with connecting silk threads. When we opened the tie-over dressing by cutting the connecting silk threads, we repeated the tie-over dressing with the same method. The skin graft was taken successfully without hematoma or seroma collection or any other complications. In conclusion, we report a novel tie-over dressing enabling simple fixation of the dressing to maintain proper tension for wounds that require repetitive fixation. Further, with this reliable method, the skin grafts were well taken.

Neural dynamics of social tie formation in economic decision-making.

Science.gov (United States)

Bault, Nadège; Pelloux, Benjamin; Fahrenfort, Johannes J; Ridderinkhof, K Richard; van Winden, Frans

2015-06-01

The disposition for prosocial conduct, which contributes to cooperation as arising during social interaction, requires cortical network dynamics responsive to the development of social ties, or care about the interests of specific interaction partners. Here, we formulate a dynamic computational model that accurately predicted how tie formation, driven by the interaction history, influences decisions to contribute in a public good game. We used model-driven functional MRI to test the hypothesis that brain regions key to social interactions keep track of dynamics in tie strength. Activation in the medial prefrontal cortex (mPFC) and posterior cingulate cortex tracked the individual's public good contributions. Activation in the bilateral posterior superior temporal sulcus (pSTS), and temporo-parietal junction was modulated parametrically by the dynamically developing social tie-as estimated by our model-supporting a role of these regions in social tie formation. Activity in these two regions further reflected inter-individual differences in tie persistence and sensitivity to behavior of the interaction partner. Functional connectivity between pSTS and mPFC activations indicated that the representation of social ties is integrated in the decision process. These data reveal the brain mechanisms underlying the integration of interaction dynamics into a social tie representation which in turn influenced the individual's prosocial decisions. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Student Mobility and Transnational Social Ties as Factors of Reflexivity

Directory of Open Access Journals (Sweden)

Tea Golob

2018-03-01

Full Text Available The article seeks to develop and apply new quantitative measurement instruments capable of significantly improving understanding of the relationship between the transnational mobility and transnational social ties of students, along with their reflexive capacities. With a focus on students building their personal networks, educational and professional activities that extend beyond the nation’s borders and organising their day-to-day routines in transnational social spaces, we analyse the role of mobility in their reflexive capacities. Applying a tool that is line with Archer’s theory and indicators to measure reflexivity, and transnational social ties as proposed by Molina et al., we analyse data collected via an on-line survey questionnaire administered to Slovenian students. In addition, students from the Middle East (Lebanon and the USA (Hawai’i are added for comparative purposes. The results of path analysis show the Slovenian students’ mobility as such implies higher scores for meta reflexivity, combined with lower scores for communicative and fractured reflexivity. Further, social transactions reaching beyond one’s physical localities in terms of transnational social ties implies they have higher levels of reflexivity in general.

Rweb:Web-based Statistical Analysis

Directory of Open Access Journals (Sweden)

Jeff Banfield

1999-03-01

Full Text Available Rweb is a freely accessible statistical analysis environment that is delivered through the World Wide Web (WWW. It is based on R, a well known statistical analysis package. The only requirement to run the basic Rweb interface is a WWW browser that supports forms. If you want graphical output you must, of course, have a browser that supports graphics. The interface provides access to WWW accessible data sets, so you may run Rweb on your own data. Rweb can provide a four window statistical computing environment (code input, text output, graphical output, and error information through browsers that support Javascript. There is also a set of point and click modules under development for use in introductory statistics courses.

The Strength of Direct Ties

DEFF Research Database (Denmark)

Claussen, Jörg; Falck, Oliver; Grosjean, Thorsten

2012-01-01

We analyze the economic effects of a developer's connectedness in the electronic game industry. Knowledge spillovers between developers are likely to be of special relevance in this knowledge-intensive and regionally concentrated industry. We calculate social network measures for a developer......'s connectedness to other developers at multiple points in time. In a regression in which we exploit within-career variation in social network measures, we find that the number of direct ties a developer has to other developers has a strong effect on both a game's revenues and critics' scores. The quality...... of indirect ties makes no additional contribution to the game's success....

Inferring tie strength from online directed behavior.

Directory of Open Access Journals (Sweden)

Jason J Jones

Full Text Available Some social connections are stronger than others. People have not only friends, but also best friends. Social scientists have long recognized this characteristic of social connections and researchers frequently use the term tie strength to refer to this concept. We used online interaction data (specifically, Facebook interactions to successfully identify real-world strong ties. Ground truth was established by asking users themselves to name their closest friends in real life. We found the frequency of online interaction was diagnostic of strong ties, and interaction frequency was much more useful diagnostically than were attributes of the user or the user's friends. More private communications (messages were not necessarily more informative than public communications (comments, wall posts, and other interactions.

Regularized Statistical Analysis of Anatomy

DEFF Research Database (Denmark)

Sjöstrand, Karl

2007-01-01

This thesis presents the application and development of regularized methods for the statistical analysis of anatomical structures. Focus is on structure-function relationships in the human brain, such as the connection between early onset of Alzheimer’s disease and shape changes of the corpus...... and mind. Statistics represents a quintessential part of such investigations as they are preluded by a clinical hypothesis that must be verified based on observed data. The massive amounts of image data produced in each examination pose an important and interesting statistical challenge...... efficient algorithms which make the analysis of large data sets feasible, and gives examples of applications....

The effects of integration and transnational ties on international return migration intentions

Directory of Open Access Journals (Sweden)

Hein de Haas

2011-12-01

Full Text Available While return migration is receiving increasing attention, there is still insufficient insight into the factors which determine migrants' intentions and decisions to return. It is often assumed that integration in receiving countries and the concomitant weakening of transnational ties decreases the likelihood of returning. However, according to alternative theoretical interpretations, return migration can also be the outflow of successful integration in receiving countries. Drawing on a data set of four African immigrant groups in Spain and Italy, this articlereviews these conflicting hypotheses by assessing the effects of integration and transnational ties on return migration intentions. The results of the analysis suggest that socio-cultural integration has a negative effect on return migration intentions, while economic integration and transnational ties have more ambiguous and sometimes positive effects. The results provide mixed support for the different hypotheses but question theoretical perspectives that unequivocally conceptualizereturn migration and transnationalism as causes and/or consequences of "integration failure".

Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice.

Science.gov (United States)

Li, Junyan; Xu, Jie; Hou, Ruifang; Jin, Xin; Wang, Jingyi; Yang, Na; Yang, Li; Liu, Li; Tao, Feng; Lu, Hao

2017-05-01

Qing-Hua Granule (QHG), the modified formulation of a classical Chinese prescription named Gegen Qinlian Decoction, was clinically employed to treat type 2 diabetes mellitus (T2DM) through regulation of glucagon-like peptide-1 (GLP-1). However, the potential mechanism is unknown. We investigate whether QHG induces GLP-1 secretion via activation of bitter taste receptor (TAS2R) pathway in the gastrointestinal tract of db/db mice. The db/db mice were intragastrically (i.g.) administered QHG (low/medium/high dose) once daily for 8 weeks. GLP-1 secretion was evaluated. The bitter receptor signaling pathway, which regulates GLP-1 secretion, including TAS2R5 (a subtype of TAS2R), α-gustducin (Gαgust), 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-2 (PLCβ2), transient receptor potential cation channel subfamily M member 5 (TRPM5), was assessed by quantitative real-time polymerase chain reaction (qRT-PCR), Western blot and immunohistochemistry (IHC). The biochemical observations of ileum and pancreas tissue were detected histopathologically. Acquity Ultra Performance LCTM - Micromass ZQ 2000 (UPLC-MS) was used for the phytochemical analysis. QHG exhibited significant and dose-dependent effect on GLP-1 secretion in db/db mice, along with significant up-regulation of TAS2R5 mRNA level and activation of TAS2R pathway (p<0.05). In addition, QHG improved the histopathological structure of ileum and pancreatic tissue. Seventeen compounds were identified in QHG. In conclusion, QHG induces GLP-1 secretion in db/db mice, most likely through the bitter taste receptor pathway. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

The Spontaneous Combustion of Railway Ties and Asphalt Shingles

Science.gov (United States)

Leslie, Geoffrey

Many Low Carbon Fuels (LCFs) present unknown spontaneous combustion risks, which must be quantified before their use as fossil fuel replacements. Wood and coal spontaneous combustion is well understood; however, LCFs weather, and subsequent chemical changes could affect their spontaneous combustion properties. LCF spontaneous combustion could lead to accidental fires with possible loss of life, limb and property. The spontaneous combustion risks of two LCFs, discarded creosote-treated wooden railway ties and roofing asphalt shingles, were investigated with calorimetry and heat transfer experiments. Chemical changes due to weathering were studied with pyrolysis-Gas Chromatography/Mass Spectrometry (py-GC/MS). Creosote-treated wooden railway tie dust, roofing asphalt shingle particles, poplar wood pellets, and petroleum coke self-heating were studied with isothermal calorimetry. Railway tie dust and asphalt shingle heat transfer were characterized with a guarded hot plate. Petroleum coke self-heating was consistent with coal, while both poplar pellets and railway tie dust were found to be more reactive compared to oven test results of similar materials. The observed increase in reactivity was probably a result of significant moisture contenint in the pellet and railway tie dust. Critical conditions for spontaneous combustion were evaluated with the Frank-Kamenetskii parameter, assuming an ambient temperature of 40°C and constant moisture content. Kamenetskii calculations indicate that a 1.6 m cube of railway tie dust, or a 58 m cube of asphalt particles, would be unstable and combust. LCF chemistry may have been affected by weathering, which would cause chemical changes that affect their spontaneous combustion properties. Therefore, railway tie wood and roofing asphalt shingle chemistry were investigated by identifying products of 250° and 550°C pyrolysis with py-GC/MS. Railway tie wood pyrolyzates did not show signs of weathering; in contrast, asphalt pyrolysis

Effect of Tower Shadow and Wind Shear in a Wind Farm on AC Tie-Line Power Oscillations of Interconnected Power Systems

DEFF Research Database (Denmark)

Tan, Jin; Hu, Weihao; Wang, Xiaoru

2013-01-01

This paper describes a frequency domain approach for evaluating the impact of tower shadow and wind shear effects (TSWS) on tie-line power oscillations. A simplified frequency domain model of an interconnected power system with a wind farm is developed. The transfer function, which relates the tie......-line power variation to the mechanical power variation of a wind turbine, and the expression of the maximum magnitude of tie-line power oscillations are derived to identify the resonant condition and evaluate the potential risk. The effects of the parameters on the resonant magnitude of the tie-line power...... are also discussed. The frequency domain analysis reveals that TSWS can excite large tie-line power oscillations if the frequency of TSWS approaches the tie-line resonant frequency, especially in the case that the wind farm is integrated into a relatively small grid and the tie-line of the interconnected...

Temperature Profile in Fuel and Tie-Tubes for Nuclear Thermal Propulsion Systems

Energy Technology Data Exchange (ETDEWEB)

Vishal Patel

2015-02-01

A finite element method to calculate temperature profiles in heterogeneous geometries of tie-tube moderated LEU nuclear thermal propulsion systems and HEU designs with tie-tubes is developed and implemented in MATLAB. This new method is compared to previous methods to demonstrate shortcomings in those methods. Typical methods to analyze peak fuel centerline temperature in hexagonal geometries rely on spatial homogenization to derive an analytical expression. These methods are not applicable to cores with tie-tube elements because conduction to tie-tubes cannot be accurately modeled with the homogenized models. The fuel centerline temperature directly impacts safety and performance so it must be predicted carefully. The temperature profile in tie-tubes is also important when high temperatures are expected in the fuel because conduction to the tie-tubes may cause melting in tie-tubes, which may set maximum allowable performance. Estimations of maximum tie-tube temperature can be found from equivalent tube methods, however this method tends to be approximate and overly conservative. A finite element model of heat conduction on a unit cell can model spatial dependence and non-linear conductivity for fuel and tie-tube systems allowing for higher design fidelity of Nuclear Thermal Propulsion.

Statistical methods for astronomical data analysis

CERN Document Server

Chattopadhyay, Asis Kumar

2014-01-01

This book introduces “Astrostatistics” as a subject in its own right with rewarding examples, including work by the authors with galaxy and Gamma Ray Burst data to engage the reader. This includes a comprehensive blending of Astrophysics and Statistics. The first chapter’s coverage of preliminary concepts and terminologies for astronomical phenomenon will appeal to both Statistics and Astrophysics readers as helpful context. Statistics concepts covered in the book provide a methodological framework. A unique feature is the inclusion of different possible sources of astronomical data, as well as software packages for converting the raw data into appropriate forms for data analysis. Readers can then use the appropriate statistical packages for their particular data analysis needs. The ideas of statistical inference discussed in the book help readers determine how to apply statistical tests. The authors cover different applications of statistical techniques already developed or specifically introduced for ...

The social ties that bind: social anxiety and academic achievement across the university years.

Science.gov (United States)

Brook, Christina A; Willoughby, Teena

2015-05-01

Given that engagement and integration in university/college are considered key to successful academic achievement, the identifying features of social anxiety, including fear of negative evaluation and distress and avoidance of new or all social situations, may be particularly disadvantageous in the social and evaluative contexts that are integral to university/college life. Thus, the purpose of this study was to examine the direct effects of social anxiety on academic achievement, as well as investigate an indirect mechanism through which social anxiety might impact on academic achievement, namely, the formation of new social ties in university. The participants were 942 (71.7 % female; M = 19 years at Time 1) students enrolled in a mid-sized university in Southern Ontario, Canada. Students completed annual assessments of social anxiety, social ties, and academic achievement for three consecutive years. The results from an autoregressive cross-lag path analysis indicated that social anxiety had a significant and negative direct relationship with academic achievement. Moreover, the negative indirect effect of social anxiety on academic achievement through social ties was significant, as was the opposing direction of effects (i.e., the indirect effect of academic achievement on social anxiety through social ties). These findings highlight the critical role that social ties appear to play in successful academic outcomes and in alleviating the effects of social anxiety during university/college.

TIE: An Ability Test of Emotional Intelligence

Science.gov (United States)

Śmieja, Magdalena; Orzechowski, Jarosław; Stolarski, Maciej S.

2014-01-01

The Test of Emotional Intelligence (TIE) is a new ability scale based on a theoretical model that defines emotional intelligence as a set of skills responsible for the processing of emotion-relevant information. Participants are provided with descriptions of emotional problems, and asked to indicate which emotion is most probable in a given situation, or to suggest the most appropriate action. Scoring is based on the judgments of experts: professional psychotherapists, trainers, and HR specialists. The validation study showed that the TIE is a reliable and valid test, suitable for both scientific research and individual assessment. Its internal consistency measures were as high as .88. In line with theoretical model of emotional intelligence, the results of the TIE shared about 10% of common variance with a general intelligence test, and were independent of major personality dimensions. PMID:25072656

TIE: an ability test of emotional intelligence.

Science.gov (United States)

Śmieja, Magdalena; Orzechowski, Jarosław; Stolarski, Maciej S

2014-01-01

The Test of Emotional Intelligence (TIE) is a new ability scale based on a theoretical model that defines emotional intelligence as a set of skills responsible for the processing of emotion-relevant information. Participants are provided with descriptions of emotional problems, and asked to indicate which emotion is most probable in a given situation, or to suggest the most appropriate action. Scoring is based on the judgments of experts: professional psychotherapists, trainers, and HR specialists. The validation study showed that the TIE is a reliable and valid test, suitable for both scientific research and individual assessment. Its internal consistency measures were as high as .88. In line with theoretical model of emotional intelligence, the results of the TIE shared about 10% of common variance with a general intelligence test, and were independent of major personality dimensions.

TIE: an ability test of emotional intelligence.

Directory of Open Access Journals (Sweden)

Magdalena Śmieja

Full Text Available The Test of Emotional Intelligence (TIE is a new ability scale based on a theoretical model that defines emotional intelligence as a set of skills responsible for the processing of emotion-relevant information. Participants are provided with descriptions of emotional problems, and asked to indicate which emotion is most probable in a given situation, or to suggest the most appropriate action. Scoring is based on the judgments of experts: professional psychotherapists, trainers, and HR specialists. The validation study showed that the TIE is a reliable and valid test, suitable for both scientific research and individual assessment. Its internal consistency measures were as high as .88. In line with theoretical model of emotional intelligence, the results of the TIE shared about 10% of common variance with a general intelligence test, and were independent of major personality dimensions.

Tongue-tie, from embriology to treatment: a literature review

Directory of Open Access Journals (Sweden)

Maria Dezio

2015-03-01

Full Text Available The aim of this review is to create a complete analysis about tongue-tie (or short lingual frenum or ankyloglossia according to the most important works published in literature. The analysis allowed us to do a complete evaluation of this problem, from embriology to the therapeutic approach we could use today, focusing our attention on laser-assisted therapy. This review is based on the research on the PubMed Database (www.ncbi.nlm.nih.gov of studies about lingual frenum written in English between January 1980 and May 2014. The keywords inserted were “lingual frenum”, “frenectomy”, “laser therapy”. We have analyzed: case series, case reports, clinical studies, and also literature reviews in which embryology, physiology, diagnosis and treatment of ankyloglossia were described. We excluded laboratory studies, studies based on animal tests and studies about patients with particular syndromes in which we can also find tongue-tie. The selection criteria allowed us to select 42 articles. The treatment options for the releasing of the frenum are surgically represented by frenotomy (i.e. simple horizontal cut of this training and frenectomy (i.e. removal. In both cases, the intervention on the short lingual frenum is simple, short-lasting, and without particular complications. Furthermore, this kind of treatment can be carried out with different devices: with the typical cold blade scalpel or by the use of laser, a new method that shows more advantages over the prior art. Laser-assisted therapy permits to intervene on newborns (from 0 to 20 days, when there are breastfeeding problems without total anesthesia and suture. The Er:YAG, CO2 laser (according to literature data and Diode laser (according to our experience are advantageous, safe and effective in tongue-tie treatment.

Freeze-thaw performance testing of whole concrete railroad ties.

Science.gov (United States)

2013-10-01

Freezing and thawing durability tests of prestressed concrete ties are normally performed according to ASTM C666 specifications. Small specimens are cut from the shoulders of concrete ties and tested through 300 cycles of freezing and thawing. Saw-cu...

New Tech, New Ties:

DEFF Research Database (Denmark)

Ling, Richard

regardless of where they are. But when we are engaged in these intimate conversations with absent friends, what happens to our relationship with the people who are actually in the same room with us? In New Tech, New Ties, Rich Ling examines how the mobile telephone affects both kinds of interactions......The message of this book is simple: the mobile phone strengthens social bonds among family and friends. With a traditional land-line telephone, we place calls to a location and ask hopefully if someone is "there"; with a mobile phone, we have instant and perpetual access to friends and family......—those mediated by mobile communication and those that are face to face. Ling finds that through the use of various social rituals the mobile telephone strengthens social ties within the circle of friends and family—sometimes at the expense of interaction with those who are physically present—and creates what he...

27 CFR 6.72 - “Tie-in” sales.

Science.gov (United States)

2010-04-01

... OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.72 “Tie-in” sales. The act by an industry member of requiring that a retailer purchase one product (as defined in § 6.11) in... and not individually. However, an industry member is not precluded from selling two or more kinds or...

Family ties and depression across the life course: An Overview

Directory of Open Access Journals (Sweden)

Nienke Moor

2012-08-01

Full Text Available BACKGROUND Family ties in Europe are affected by demographic trends associated with parenting and partnering, such as a decline in fertility, an increase in childlessness, postponement of parenthood and of partnership formation, the rise of "new" relationship forms and divorce rates. It is unclear how the contemporary family structure and composition are associated with people's mental wellbeing. OBJECTIVE This article examines how ties with parents, siblings, a partner and children are associated with depressive mood of men and women in seven Eastern and Western European countries. METHODS To test our hypotheses we made use of data from the Generations and Gender Surveys. We performed logistic regression analyses to study the associations between people's family ties and depressive mood. RESULTS Our research findings show that family ties can diminish people's depressive feelings. Although we find some gender differences in these associations, we do not find support for the argument that family ties are more important for the mental wellbeing of women than of men. Moreover, our findings support the hierarchical model of family relations in which new ties with partner and children in adulthood gain precedence over the original primary ties with parents and siblings. Finally, we find that the association between family ties and depressive mood is quite similar in Eastern and Western Europe, but being married or having a partner more strongly reduces depressive feelings in Eastern than in Western Europe. CONCLUSIONS Although we did not dispose of longitudinal data, our research results do provide some indications about how demographic changes, for instance, those affecting family size -- the number of children or siblings -- might be associated with mental wellbeing. Our findings also suggest that the demographic trend of increasing partnership dissolution may have larger consequences for people's mental wellbeing in Eastern

Tying Trade Flows: A Theory of Countertrade

OpenAIRE

Marin, Dalia; Schnitzer, Monika

1994-01-01

A countertrade contract ties an export to an import. Usually, countertrade is seen as a form of bilateralism and reciprocity and thus as an inefficient form of international exchange. In this paper we argue that there are circumstances where the tying of two technologically unrelated trade flows may be efficiency enhancing. We show that countertrade can be seen as an efficient institution that solves moral hazard problems and restores creditworthiness of countries with large outstanding debt....

Decentralized automatic generation control of interconnected power systems incorporating asynchronous tie-lines.

Science.gov (United States)

Ibraheem; Hasan, Naimul; Hussein, Arkan Ahmed

2014-01-01

This Paper presents the design of decentralized automatic generation controller for an interconnected power system using PID, Genetic Algorithm (GA) and Particle Swarm Optimization (PSO). The designed controllers are tested on identical two-area interconnected power systems consisting of thermal power plants. The area interconnections between two areas are considered as (i) AC tie-line only (ii) Asynchronous tie-line. The dynamic response analysis is carried out for 1% load perturbation. The performance of the intelligent controllers based on GA and PSO has been compared with the conventional PID controller. The investigations of the system dynamic responses reveal that PSO has the better dynamic response result as compared with PID and GA controller for both type of area interconnection.

The social tie and the malaise facing the helplessness

Directory of Open Access Journals (Sweden)

Cristina Aparecida Tannure Cavalcanti

2015-12-01

Full Text Available In this article we intend to approach the discourses as social ties, indicated by Lacan, relating them to the freudian concepts of helplessness (Hilflosigkeit and the malaise of civilization. The theory of discourses opens up a new way of thinking about clinical structures and social ties, by articulating language and enjoyment camps, the subject and the unconscious knowledge. This theory, while it takes over Freudian principles, it advances in impasses left by the Viennese master, in particular on the relationship between the metapsychological foundations of the subjective constitution and the conceptual bases concerning culture and actual social ties.

Importance of tie strengths in the prisoner's dilemma game on social networks

International Nuclear Information System (INIS)

Xu, Bo; Liu, Lu; You, Weijia

2011-01-01

Though numerous researches have shown that tie strengths play a key role in the formation of collective behavior in social networks, little work has been done to explore their impact on the outcome of evolutionary games. In this Letter, we studied the effect of tie strength in the dynamics of evolutionary prisoner's dilemma games by using online social network datasets. The results show that the fraction of cooperators has a non-trivial dependence on tie strength. Weak ties, just like previous researches on epidemics and information diffusion have shown, play a key role by the maintenance of cooperators in evolutionary prisoner's dilemma games. -- Highlights: → Tie strength is used to measure heterogeneous influences of different pairs of nodes. → Weak ties play a role in maintaining cooperation in prisoner's dilemma games. → Micro-dynamics of nodes are illustrated to explain the conclusion.

INCUBATORS WITHIN UNIVERSITY AND CLUSTERED CONTEXTS: CASES OF NATIONAL CHIAO TUNG UNIVERSITY (NCTU AND NATIONAL TSING HUA UNIVERSITY (NTHU INCUBATORS IN HSINCHU, TAIWAN

Directory of Open Access Journals (Sweden)

Khairul Akmaliah Adham

2008-01-01

Full Text Available Research literature on business incubators has highlighted the significance of clustered locational contexts and networking as key to an incubator's success. Using the case study approach, this study aimed to test the validity of this framework for explaining the level of success of the National Chiao Tung University (NCTU and National Tsing Hua University (NTHU Incubators in Hsinchu, Taiwan – both of which are highly-networked, cluster-centric and university-based. In-depth interviews were conducted with the managers of both incubators, and these were followed by information gathering on university patents and knowledge transfers from the research and development (R&D office at each university. Analysis found that the incubators' locational contexts determined the degree and manner of their networking, but their profitability and growth potential were influenced by many other factors working in combination. Satisfying their sponsors' requirements and serving their core functions through sound management and strategic planning appeared to be the key to achieving profitability and sustainability, with benefits for all stakeholders. These constructs provide directions for more research on the performance of incubators and other business entities that are located within university and clustered contexts.

IVF, same-sex couples and the value of biological ties.

Science.gov (United States)

Di Nucci, Ezio

2016-12-01

Ought parents, in general, to value being biologically tied to their children? Is it important, in particular, that both parents be biologically tied to their children? I will address these fundamental questions by looking at a fairly new practice within IVF treatments, so-called IVF-with-ROPA (Reception of Oocytes from Partner), which allows lesbian couples to 'share motherhood', with one partner providing the eggs while the other becomes pregnant. I believe that IVF-with-ROPA is, just like other IVF treatments, morally permissible, but here I argue that the increased biological ties which IVF-with-ROPA allows for do not have any particular value beside the satisfaction of a legitimate wish, because there is no intrinsic value in a biological tie between parents and children; further, I argue that equality within parental projects cannot be achieved by redistributing biological ties. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

A Statistical Toolkit for Data Analysis

International Nuclear Information System (INIS)

Donadio, S.; Guatelli, S.; Mascialino, B.; Pfeiffer, A.; Pia, M.G.; Ribon, A.; Viarengo, P.

2006-01-01

The present project aims to develop an open-source and object-oriented software Toolkit for statistical data analysis. Its statistical testing component contains a variety of Goodness-of-Fit tests, from Chi-squared to Kolmogorov-Smirnov, to less known, but generally much more powerful tests such as Anderson-Darling, Goodman, Fisz-Cramer-von Mises, Kuiper, Tiku. Thanks to the component-based design and the usage of the standard abstract interfaces for data analysis, this tool can be used by other data analysis systems or integrated in experimental software frameworks. This Toolkit has been released and is downloadable from the web. In this paper we describe the statistical details of the algorithms, the computational features of the Toolkit and describe the code validation

Can space ties on board GNSS satellites replace terrestrial ties in the implementation of Terrestrial Reference Frames?

Science.gov (United States)

Bruni, Sara; Zerbini, Susanna; Altamimi, Zuheir; Rebischung, Paul; Errico, Maddalena; Santi, Efisio

2016-04-01

The realization of Terrestrial Reference Frames (TRFs) must be periodically updated in order to account for newly acquired observations and for upgrades in data analysis procedures and/or combination techniques. Any innovative computation strategy should ameliorate the definition of the frame physical parameters, upon which a number of scientific applications critically rely. On the basis of the requirements of scientific cutting edge studies, the geodetic community has estimated that the present day challenge in the determination of TRFs is to provide a frame that is accurate and long-term stable at the level of 1 mm and 0.1 mm/y respectively. This work aims at characterizing the frame realized by a combination of Satellite Laser Ranging (SLR) and Global Navigation Satellite Systems (GNSS) observations via their co-location on board GNSS spacecrafts. In particular, it is established how such a frame compares to the traditional ITRF computation and what is the impact on the realization of the frame origin and scale. Four years of data from a global network encompassing about one hundred GNSS stations and all SLR sites have been analyzed. In order to ensure the highest possible consistency, the raw data of both techniques are treated with the same analysis Software (Bernese GNSS Software 5.2) following IERS2010 Conventions. Both weekly and long term solutions are carried out exploiting either the Bernese or the Combination and Analysis of Terrestrial Reference Frames (CATREF) Software packages. We present the results of a combination study involving GNSS data and SLR observations to the two LAGEOS and to the GNSS satellites equipped with retroreflector arrays. The latter type of measurements is currently not included in the computation of the official ITRF solutions. The assessment of the benefit that they could provide to the definition of the origin and scale of the ITRF is however worth investigating, as such data provide the potential for linking the GNSS and

Statistical considerations on safety analysis

International Nuclear Information System (INIS)

Pal, L.; Makai, M.

2004-01-01

The authors have investigated the statistical methods applied to safety analysis of nuclear reactors and arrived at alarming conclusions: a series of calculations with the generally appreciated safety code ATHLET were carried out to ascertain the stability of the results against input uncertainties in a simple experimental situation. Scrutinizing those calculations, we came to the conclusion that the ATHLET results may exhibit chaotic behavior. A further conclusion is that the technological limits are incorrectly set when the output variables are correlated. Another formerly unnoticed conclusion of the previous ATHLET calculations that certain innocent looking parameters (like wall roughness factor, the number of bubbles per unit volume, the number of droplets per unit volume) can influence considerably such output parameters as water levels. The authors are concerned with the statistical foundation of present day safety analysis practices and can only hope that their own misjudgment will be dispelled. Until then, the authors suggest applying correct statistical methods in safety analysis even if it makes the analysis more expensive. It would be desirable to continue exploring the role of internal parameters (wall roughness factor, steam-water surface in thermal hydraulics codes, homogenization methods in neutronics codes) in system safety codes and to study their effects on the analysis. In the validation and verification process of a code one carries out a series of computations. The input data are not precisely determined because measured data have an error, calculated data are often obtained from a more or less accurate model. Some users of large codes are content with comparing the nominal output obtained from the nominal input, whereas all the possible inputs should be taken into account when judging safety. At the same time, any statement concerning safety must be aleatory, and its merit can be judged only when the probability is known with which the

Performance evaluation of concrete railroad ties on the northeast corridor.

Science.gov (United States)

2014-03-01

Simpson Gumpertz & Heger Inc. conducted an investigation into the factors that caused widespread failure in prestressed concrete : railroad ties on the Northeast Corridor. The problem was apparent in ties manufactured and installed circa 19941998....

Statistical shape analysis with applications in R

CERN Document Server

Dryden, Ian L

2016-01-01

A thoroughly revised and updated edition of this introduction to modern statistical methods for shape analysis Shape analysis is an important tool in the many disciplines where objects are compared using geometrical features. Examples include comparing brain shape in schizophrenia; investigating protein molecules in bioinformatics; and describing growth of organisms in biology. This book is a significant update of the highly-regarded `Statistical Shape Analysis’ by the same authors. The new edition lays the foundations of landmark shape analysis, including geometrical concepts and statistical techniques, and extends to include analysis of curves, surfaces, images and other types of object data. Key definitions and concepts are discussed throughout, and the relative merits of different approaches are presented. The authors have included substantial new material on recent statistical developments and offer numerous examples throughout the text. Concepts are introduced in an accessible manner, while reta...

Spatial analysis statistics, visualization, and computational methods

CERN Document Server

Oyana, Tonny J

2015-01-01

An introductory text for the next generation of geospatial analysts and data scientists, Spatial Analysis: Statistics, Visualization, and Computational Methods focuses on the fundamentals of spatial analysis using traditional, contemporary, and computational methods. Outlining both non-spatial and spatial statistical concepts, the authors present practical applications of geospatial data tools, techniques, and strategies in geographic studies. They offer a problem-based learning (PBL) approach to spatial analysis-containing hands-on problem-sets that can be worked out in MS Excel or ArcGIS-as well as detailed illustrations and numerous case studies. The book enables readers to: Identify types and characterize non-spatial and spatial data Demonstrate their competence to explore, visualize, summarize, analyze, optimize, and clearly present statistical data and results Construct testable hypotheses that require inferential statistical analysis Process spatial data, extract explanatory variables, conduct statisti...

ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

Science.gov (United States)

Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

2016-02-15

Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Modelling of bow-tie microstrip antennas using modified locally conformal FDTD method

NARCIS (Netherlands)

George, J.

2000-01-01

An analysis of bow-tie microstrip antennas is presented based on the use of the modified locally conformal finite-difference time-domain (FDTD) method. This approach enables the number of cells along the antenna length and width to be chosen independently of the antenna central width, which helps to

Application of descriptive statistics in analysis of experimental data

OpenAIRE

Mirilović Milorad; Pejin Ivana

2008-01-01

Statistics today represent a group of scientific methods for the quantitative and qualitative investigation of variations in mass appearances. In fact, statistics present a group of methods that are used for the accumulation, analysis, presentation and interpretation of data necessary for reaching certain conclusions. Statistical analysis is divided into descriptive statistical analysis and inferential statistics. The values which represent the results of an experiment, and which are the subj...

The Strength of the Strongest Ties in Collaborative Problem Solving

DEFF Research Database (Denmark)

de Montjoye, Yves-Alexandre; Stopczynski, Arkadiusz; Shmueli, Erez

2014-01-01

Complex problem solving in science, engineering, and business has become a highly collaborative endeavor. Teams of scientists or engineers collaborate on projects using their social networks to gather new ideas and feedback. Here we bridge the literature on team performance and information networks...... by studying teams' problem solving abilities as a function of both their within-team networks and their members' extended networks. We show that, while an assigned team's performance is strongly correlated with its networks of expressive and instrumental ties, only the strongest ties in both networks have...... an effect on performance. Both networks of strong ties explain more of the variance than other factors, such as measured or self-evaluated technical competencies, or the personalities of the team members. In fact, the inclusion of the network of strong ties renders these factors non...

IVF, same-sex couples and the value of biological ties

DEFF Research Database (Denmark)

Di Nucci, Ezio

2016-01-01

Ought parents, in general, to value being biologically tied to their children? Is it important, in particular, that both parents be biologically tied to their children? I will address these fundamental questions by looking at a fairly new practice within IVF treatments, so-called IVF......-with-ROPA (Reception of Oocytes from Partner), which allows lesbian couples to 'share motherhood', with one partner providing the eggs while the other becomes pregnant. I believe that IVF-with-ROPA is, just like other IVF treatments, morally permissible, but here I argue that the increased biological ties which IVF...

Identifying Weak Ties from Publicly Available Social Media Data in an Event

DEFF Research Database (Denmark)

Prakash Gupta, Jayesh; Menon, Karan; Kärkkäinen, Hannu

2016-01-01

The concept of weak ties was introduced by Granovetter through the seminal paper titled "Strength of weak ties". Since then the role of weak ties in general and their specific role as occupying the structural hole has been explored in many different fields. In this study, we identify actual or po...

Statistical Analysis of Research Data | Center for Cancer Research

Science.gov (United States)

Recent advances in cancer biology have resulted in the need for increased statistical analysis of research data. The Statistical Analysis of Research Data (SARD) course will be held on April 5-6, 2018 from 9 a.m.-5 p.m. at the National Institutes of Health's Natcher Conference Center, Balcony C on the Bethesda Campus. SARD is designed to provide an overview on the general principles of statistical analysis of research data.  The first day will feature univariate data analysis, including descriptive statistics, probability distributions, one- and two-sample inferential statistics.

United States, Europe and Poland Different Stages of Antitrust Tying War in the New Economy

Directory of Open Access Journals (Sweden)

Mariusz SWORA

2006-06-01

Full Text Available Microsoft’s case has led to heated debates, both in Europe and the United States of America, on the abuse of the dominant position and on the prohibition of tying. This discussion, both in Europe and the United States, is not finished. In this article the author presents legal implications of tying products in Europe and Poland and confronts them with the American approach to tying. In Poland, a country with a fast developing economy, with the growing level of foreign investments, discussion on monopolist practices under the conditions of a fast technological development1 has not really commenced yet. The problems of innovation and development of New Economy undertakings has gained new impetus following Poland’s accession to the European Union. It is a matter of time when the anti-trust law begins to show interest in them. There are some indications that this has already taken place. In the first part of this article the author briefly presents the discussion related to Microsoft III case in the United States insofar as it pertains to New Economy issues. The second and third parts address legal and political aspects of the Microsoft case in the European Union. In the fourth part legal aspects related to tying practices in Poland are presented. The article aims to show that instrumental and mechanical treatment of tying practices used by firms having the market power under conditions of technological progress is not proper. The problem of antitrust analysis of such practices is universal, as universal as these practices are. However, the problem is solved differently in the United States and in Europe and the reasons for such a different approach are rooted in the legal system and policy enforcement. Microsoft antitrust is global. After US and European cases, Korean competition authority has found Microsoft guilty of tying practices2. Regarding Microsoft problems with tying it is necessary to ask the question whether tying practices are

Distinct RNA transcriptome patterns are potentially associated with angiogenesis in Tie2-expressing monocytes.

Science.gov (United States)

Wang, Xinjing; Dai, Zhiyuan; Wu, Xiaoli; Wang, Kai; Wang, Xipeng

2016-04-10

Tie2-expressing Monocytes (TEMs) were previously identified as a novel subset of monocytes and were believed to have prominent pro-angiogenesis activities in human tumors. While the molecular mechanism of the angiogenesis promoting capacity of TEMs remains unclear. RNA transcriptome pattern, including non-coding RNAs as microRNA (miRNA) and long non-coding RNA (lncRNA), plays important role in cell differentiation and functions. However, little is known about the transcriptome patterns of TEMs, including those non-coding RNAs. We explore the transcriptome of TEMs and the matched monocytes that do not express Tie2 (Tie2(-)monocytes) isolated from peripheral blood of healthy adults employing the Agilent Human miRNA(8*60K,Design ID: 046064)microarray and the Agilent lncRNA Gene Expression(4*180K, Design ID: 042818)microarray. A total of 141 mRNAs, 142 lncRNAs and 75 miRNAs were found dysregulated in TEMs compared to Tie2(-)monocytes. TEMs have the distinct RNA transcriptome patterns according to the Hierarchical clustering and then the gene expression patterns were confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Functional annotation by Gene Ontology (GO) analyses showed that the up-regulated mRNAs in TEMs were associated to blood vessel remodeling and positive regulation of epithelial cell proliferation, and the up-regulated insulin like growth factor 1(IGF1) mRNA was involved in both pathways. For functional analysis of those dysregulated non-coding RNAs, target genes of the miRNAs were predicted and cis/trans-regulation analysis of the lncRNAs were performed. Copyright © 2016 Elsevier B.V. All rights reserved.

Total integrated energy system (TIES) feasibility analysis for the downtown redevelopment project, Pasadena, California

Energy Technology Data Exchange (ETDEWEB)

None

1977-04-01

The purpose of this study is to determine the most desirable method of serving the energy needs of a commercial development to be constructed in Pasadena, California. The factors that determine maximum desirability consist of the following: (1) maximum economic benefit to the energy user and to the surrounding community; (2) minimum usage of energy by both the energy user and the surrounding community; and (3) minimum introduction of pollutants into the community. The methods studied were the Total Integrated Energy System (TIES) concept in several configurations. The TIES concept differs from the ''total energy concept'' in the respect that the electric power output of the local power generation plant goes into the utility company distribution grid, rather than to the user. The user is served power from the grid, as with a conventional system, but also receives heating and cooling media produced from power generation by-product heat from the TIES plant. The effect of this concept is that a very large source-sink for electric energy is provided by the utility company grid. This, in turn, permits the plant to operate in response to instantaneous thermal demand, rather than instantaneous power demand. No auxiliary firing is ever required. No waste of unneeded by-product energy to atmosphere ever occurs. Balance is achieved by either delivering excess power into the grid or by withdrawing power production deficiency from the grid. Near-optimum efficiency is achieved during all operating conditions. There is no need whatsoever for the power-generating plant to be sized to meet the power demand, since it seldom, if ever, tracks the power demand. Sizing of the electric generation is solely a function of economics and the demand for waste heat.

Statistical analysis with Excel for dummies

CERN Document Server

Schmuller, Joseph

2013-01-01

Take the mystery out of statistical terms and put Excel to work! If you need to create and interpret statistics in business or classroom settings, this easy-to-use guide is just what you need. It shows you how to use Excel's powerful tools for statistical analysis, even if you've never taken a course in statistics. Learn the meaning of terms like mean and median, margin of error, standard deviation, and permutations, and discover how to interpret the statistics of everyday life. You'll learn to use Excel formulas, charts, PivotTables, and other tools to make sense of everything fro

[Medical equipment companies and their ties with technology development centers in Mexico].

Science.gov (United States)

Hernández, B; Arredondo, A; Cruz, C; Sánchez, E; Damián, T

1993-10-01

The purpose of this study was to determine the characteristics of the companies that produce, distribute, and service medical equipment in Mexico and the factors related to whether or not they had established ties with research and technology development centers. The data analyzed came from a survey of such companies carried out in Mexico City and environs in 1989. The information was updated in 1991. Multivariate analyses were carried out in order to identify the characteristics of companies that had established ties or wished to do so and the areas of interest of those companies. Of 208 companies surveyed, only 23% had ties with research centers. The companies that had such ties or were interested in establishing them tended to invest in research and to have made plans for expansion. The establishment of ties appeared to be a two-way process, with positive consequences for the companies involved, the research centers, and the health sector. It was concluded that it would be advantageous to design programs to promote ties with companies having the characteristics mentioned.

Binding energy of donor impurity states and optical absorption in the Tietz-Hua quantum well under an applied electric field

Science.gov (United States)

Al, E. B.; Kasapoglu, E.; Sakiroglu, S.; Duque, C. A.; Sökmen, I.

2018-04-01

For a quantum well which has the Tietz-Hua potential, the ground and some excited donor impurity binding energies and the total absorption coefficients, including linear and third order nonlinear terms for the transitions between the related impurity states with respect to the structure parameters and the impurity position as well as the electric field strength are investigated. The binding energies were obtained using the effective-mass approximation within a variational scheme and the optical transitions between any two impurity states were calculated by using the density matrix formalism and the perturbation expansion method. Our results show that the effects of the electric field and the structure parameters on the optical transitions are more pronounced. So we can adjust the red or blue shift in the peak position of the absorption coefficient by changing the strength of the electric field as well as the structure parameters.

Statistical analysis of dynamic parameters of the core

International Nuclear Information System (INIS)

Ionov, V.S.

2007-01-01

The transients of various types were investigated for the cores of zero power critical facilities in RRC KI and NPP. Dynamic parameters of neutron transients were explored by tool statistical analysis. Its have sufficient duration, few channels for currents of chambers and reactivity and also some channels for technological parameters. On these values the inverse period. reactivity, lifetime of neutrons, reactivity coefficients and some effects of a reactivity are determinate, and on the values were restored values of measured dynamic parameters as result of the analysis. The mathematical means of statistical analysis were used: approximation(A), filtration (F), rejection (R), estimation of parameters of descriptive statistic (DSP), correlation performances (kk), regression analysis(KP), the prognosis (P), statistician criteria (SC). The calculation procedures were realized by computer language MATLAB. The reasons of methodical and statistical errors are submitted: inadequacy of model operation, precision neutron-physical parameters, features of registered processes, used mathematical model in reactivity meters, technique of processing for registered data etc. Examples of results of statistical analysis. Problems of validity of the methods used for definition and certification of values of statistical parameters and dynamic characteristics are considered (Authors)

Selection based on the size of the black tie of the great tit may be reversed in urban habitats.

Science.gov (United States)

Senar, Juan Carlos; Conroy, Michael J; Quesada, Javier; Mateos-Gonzalez, Fernando

2014-07-01

A standard approach to model how selection shapes phenotypic traits is the analysis of capture-recapture data relating trait variation to survival. Divergent selection, however, has never been analyzed by the capture-recapture approach. Most reported examples of differences between urban and nonurban animals reflect behavioral plasticity rather than divergent selection. The aim of this paper was to use a capture-recapture approach to test the hypothesis that divergent selection can also drive local adaptation in urban habitats. We focused on the size of the black breast stripe (i.e., tie width) of the great tit (Parus major), a sexual ornament used in mate choice. Urban great tits display smaller tie sizes than forest birds. Because tie size is mostly genetically determined, it could potentially respond to selection. We analyzed capture/recapture data of male great tits in Barcelona city (N = 171) and in a nearby (7 km) forest (N = 324) from 1992 to 2008 using MARK. When modelling recapture rate, we found it to be strongly influenced by tie width, so that both for urban and forest habitats, birds with smaller ties were more trap-shy and more cautious than their larger tied counterparts. When modelling survival, we found that survival prospects in forest great tits increased the larger their tie width (i.e., directional positive selection), but the reverse was found for urban birds, with individuals displaying smaller ties showing higher survival (i.e., directional negative selection). As melanin-based tie size seems to be related to personality, and both are heritable, results may be explained by cautious personalities being favored in urban environments. More importantly, our results show that divergent selection can be an important mechanism in local adaptation to urban habitats and that capture-recapture is a powerful tool to test it.

Reciprocity, social ties, and competition in markets for experience goods

DEFF Research Database (Denmark)

Huck, Steffen; Tyran, Jean-Robert

2007-01-01

a positive externality for non-reciprocal customers who would, in the absence of reciprocal types, face market breakdown. This efficiency-enhancing effect of reciprocity is boosted when there are social ties between consumers and competition between firms. The existence of social ties or competition alone...

Employees and Creativity: Social Ties and Access to Heterogeneous Knowledge

Science.gov (United States)

Huang, Chiung-En; Liu, Chih-Hsing Sam

2015-01-01

This study dealt with employee social ties, knowledge heterogeneity contacts, and the generation of creativity. Although prior studies demonstrated a relationship between network position and creativity, inadequate attention has been paid to network ties and heterogeneity knowledge contacts. This study considered the social interaction processes…

Importance of tie strengths in the prisoner's dilemma game on social networks

Science.gov (United States)

Xu, Bo; Liu, Lu; You, Weijia

2011-06-01

Though numerous researches have shown that tie strengths play a key role in the formation of collective behavior in social networks, little work has been done to explore their impact on the outcome of evolutionary games. In this Letter, we studied the effect of tie strength in the dynamics of evolutionary prisoner's dilemma games by using online social network datasets. The results show that the fraction of cooperators has a non-trivial dependence on tie strength. Weak ties, just like previous researches on epidemics and information diffusion have shown, play a key role by the maintenance of cooperators in evolutionary prisoner's dilemma games.

CONFIDENCE LEVELS AND/VS. STATISTICAL HYPOTHESIS TESTING IN STATISTICAL ANALYSIS. CASE STUDY

Directory of Open Access Journals (Sweden)

ILEANA BRUDIU

2009-05-01

Full Text Available Estimated parameters with confidence intervals and testing statistical assumptions used in statistical analysis to obtain conclusions on research from a sample extracted from the population. Paper to the case study presented aims to highlight the importance of volume of sample taken in the study and how this reflects on the results obtained when using confidence intervals and testing for pregnant. If statistical testing hypotheses not only give an answer "yes" or "no" to some questions of statistical estimation using statistical confidence intervals provides more information than a test statistic, show high degree of uncertainty arising from small samples and findings build in the "marginally significant" or "almost significant (p very close to 0.05.

Collecting operational event data for statistical analysis

International Nuclear Information System (INIS)

Atwood, C.L.

1994-09-01

This report gives guidance for collecting operational data to be used for statistical analysis, especially analysis of event counts. It discusses how to define the purpose of the study, the unit (system, component, etc.) to be studied, events to be counted, and demand or exposure time. Examples are given of classification systems for events in the data sources. A checklist summarizes the essential steps in data collection for statistical analysis

Developing an Objective Structured Assessment of Technical Skills for Laparoscopic Suturing and Intracorporeal Knot Tying.

Science.gov (United States)

Chang, Olivia H; King, Louise P; Modest, Anna M; Hur, Hye-Chun

2016-01-01

To develop a teaching and assessment tool for laparoscopic suturing and intracorporeal knot tying. We designed an Objective Structured Assessment of Technical Skills (OSATS) tool that includes a procedure-specific checklist (PSC) and global rating scale (GRS) to assess laparoscopic suturing and intracorporeal knot-tying performance. Obstetrics and Gynecology residents at our institution were videotaped while performing a laparoscopic suturing and intracorporeal knot-tying task at a surgical simulation workshop. A total of 2 expert reviewers assessed resident performance using the OSATS tool during live performance and 1 month later using the videotaped recordings. OSATS scores were analyzed using the Wilcoxon rank-sum test. Data are presented as median scores (interquartile range [IQR]). Intrarater and interrater reliabilities were assessed using a Spearman correlation and are presented as an r correlation coefficient and p value. An r ≥ 0.8 was considered as a high correlation. After testing, we received feedback from residents and faculty to improve the OSATS tool as part of an iterative design process. In all, 14 of 21 residents (66.7%) completed the study, with 9 junior residents and 5 senior residents. Junior residents had a lower score on the PSC than senior residents did; however, this was not statistically significant (median = 6.0 [IQR: 4.0-10.0] and median = 13.0 [IQR: 10.0-13.0]; p = 0.09). There was excellent intrarater reliability with our OSATS tool (for PSC component, r = 0.88 for Rater 1 and 0.93 for Rater 2, both p assessment and teaching tool for laparoscopic suturing and intracorporeal knot-tying skills. Overall, good intrarater reliability was demonstrated, suggesting that this tool may be useful for longitudinal assessment of surgical skills. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

The Strength of the Strongest Ties in Collaborative Problem Solving

DEFF Research Database (Denmark)

de Montjoye, Yves-Alexandre; Stopczynski, Arkadiusz; Shmueli, Erez

2014-01-01

an effect on performance. Both networks of strong ties explain more of the variance than other factors, such as measured or self-evaluated technical competencies, or the personalities of the team members. In fact, the inclusion of the network of strong ties renders these factors non...

Statistics and analysis of scientific data

CERN Document Server

Bonamente, Massimiliano

2013-01-01

Statistics and Analysis of Scientific Data covers the foundations of probability theory and statistics, and a number of numerical and analytical methods that are essential for the present-day analyst of scientific data. Topics covered include probability theory, distribution functions of statistics, fits to two-dimensional datasheets and parameter estimation, Monte Carlo methods and Markov chains. Equal attention is paid to the theory and its practical application, and results from classic experiments in various fields are used to illustrate the importance of statistics in the analysis of scientific data. The main pedagogical method is a theory-then-application approach, where emphasis is placed first on a sound understanding of the underlying theory of a topic, which becomes the basis for an efficient and proactive use of the material for practical applications. The level is appropriate for undergraduates and beginning graduate students, and as a reference for the experienced researcher. Basic calculus is us...

The centrality of social ties to climate migration and mental health.

Science.gov (United States)

Torres, Jacqueline M; Casey, Joan A

2017-07-06

Climate change-related hazards and disasters, known to adversely impact physical and mental health outcomes, are also expected to result in human migration above current levels. Environmentally-motivated migration and displacement may lead to the disruption of existing social ties, with potentially adverse consequences for mobile populations as well as their family members who remain in places of origin. We propose that the disruption of social ties is a key mechanism by which climate-related migration may negatively impact mental health, in particular. Existing social ties may provide social and material resources that buffer mental health stressors related to both prolonged and acute climate events. Preparation for such events may also strengthen these same ties and protect mental health. Communities may leverage social ties, first to mitigate climate change, and second, to adapt and rebuild post-disaster in communities of origin. Additionally, social ties can inform migration decisions and destinations. For example, scholars have found that the drought-motivated adaptive migration of West African Fulbe herders only occurred because of the long-term development of social networks between migrants and non-migrants through trade and seasonal grazing. On the other hand, social ties do not always benefit mental health. Some migrants, including those from poor regions or communities with no formal safety net, may face considerable burden to provide financial and emotional resources to family members who remain in countries of origin. In destination communities, migrants often face significant social marginalization. Therefore, policies and programs that aim to maintain ongoing social ties among migrants and their family and community members may be critically important in efforts to enhance population resilience and adaptation to climate change and to improve mental health outcomes. Several online platforms, like Refugee Start Force, serve to integrate refugees by

The centrality of social ties to climate migration and mental health

Directory of Open Access Journals (Sweden)

Jacqueline M. Torres

2017-07-01

Full Text Available Abstract Climate change-related hazards and disasters, known to adversely impact physical and mental health outcomes, are also expected to result in human migration above current levels. Environmentally-motivated migration and displacement may lead to the disruption of existing social ties, with potentially adverse consequences for mobile populations as well as their family members who remain in places of origin. We propose that the disruption of social ties is a key mechanism by which climate-related migration may negatively impact mental health, in particular. Existing social ties may provide social and material resources that buffer mental health stressors related to both prolonged and acute climate events. Preparation for such events may also strengthen these same ties and protect mental health. Communities may leverage social ties, first to mitigate climate change, and second, to adapt and rebuild post-disaster in communities of origin. Additionally, social ties can inform migration decisions and destinations. For example, scholars have found that the drought-motivated adaptive migration of West African Fulbe herders only occurred because of the long-term development of social networks between migrants and non-migrants through trade and seasonal grazing. On the other hand, social ties do not always benefit mental health. Some migrants, including those from poor regions or communities with no formal safety net, may face considerable burden to provide financial and emotional resources to family members who remain in countries of origin. In destination communities, migrants often face significant social marginalization. Therefore, policies and programs that aim to maintain ongoing social ties among migrants and their family and community members may be critically important in efforts to enhance population resilience and adaptation to climate change and to improve mental health outcomes. Several online platforms, like Refugee Start Force

Sheng-ji Hua-yu formula promotes diabetic wound healing of re-epithelization via Activin/Follistatin regulation.

Science.gov (United States)

Kuai, Le; Zhang, Jing-Ting; Deng, Yu; Xu, Shun; Xu, Xun-Zhe; Wu, Min-Feng; Guo, Dong-Jie; Chen, Yu; Wu, Ren-Jie; Zhao, Xing-Qiang; Nian, Hua; Li, Bin; Li, Fu-Lun

2018-01-29

Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how the SJHY Formula affects excessive inflammation in the process of re-epithelialization of diabetic wound healing is a task urgently needed to be fulfilled. The objectives of this study is to evaluate the effect of antagonisic expression of pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin) in the process of re-epithelialization of diabetic wound healing in vivo, and to characterize the involvement of the activin/follistatin protein expression regulation, phospho-Smad (pSmad2), and Nuclear factor kappa B p50 (NF-kB) p50 in the diabetic wound healing effects of SJHY formula. SJHY Formula was prepared by pharmaceutical preparation room of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. Diabetic wound healing activity was evaluated by circular excision wound models. Wound healing activity was examined by macroscopic evaluation. Activin/follistatin expression regulation, protein expression of pSmad2 and NF-kB p50 in skin tissue of wounds were analyzed by Real Time PCR, Western blot, immunohistochemistry and hematoxylin and eosin (H&E) staining. Macroscopic evaluation analysis showed that wound healing of diabetic mice was delayed, and SJHY Formula accelerated wound healing time of diabetic mice. Real Time PCR analysis showed higher mRNA expression of activin/follistatin in diabetic delayed wound versus the wound in normal mice. Western Blot immunoassay analysis showed reduction of activin/follistatin proteins levels by SJHY Formula treatment 15 days after injury. Immunohistochemistry investigated the reduction of pSmad2 and NF-kB p50 nuclear staining in the epidermis of diabetic SJHY versus diabetic control mice on day 15 after wounding. H&E staining revealed that SJHY Formula

Robust tie points selection for InSAR image coregistration

Science.gov (United States)

Skanderi, Takieddine; Chabira, Boulerbah; Afifa, Belkacem; Belhadj Aissa, Aichouche

2013-10-01

Image coregistration is an important step in SAR interferometry which is a well known method for DEM generation and surface displacement monitoring. A practical and widely used automatic coregistration algorithm is based on selecting a number of tie points in the master image and looking for the correspondence of each point in the slave image using correlation technique. The characteristics of these points, their number and their distribution have a great impact on the reliability of the estimated transformation. In this work, we present a method for automatic selection of suitable tie points that are well distributed over the common area without decreasing the desired tie points' number. First we select candidate points using Harris operator. Then from these points we select tie points depending on their cornerness measure (the highest first). Once a tie point is selected, its correspondence is searched for in the slave image, if the similarity measure maximum is less than a given threshold or it is at the border of the search window, this point is discarded and we proceed to the next Harris point, else, the cornerness of the remaining candidates Harris points are multiplied by a spatially radially increasing function centered at the selected point to disadvantage the points in a neighborhood of a radius determined from the size of the common area and the desired number of points. This is repeated until the desired number of points is selected. Results of an ERS1/2 tandem pair are presented and discussed.

Fiber Optic Tamper Indicating Enclosure (TIE); A Case Study in Authentication

Energy Technology Data Exchange (ETDEWEB)

Anheier, Norman C.; Benz, Jacob M.; Tanner, Jennifer E.; Westman, Matthew P.

2015-07-15

A robust fiber optic-based tamper-indicating enclosure (TIE) has been developed by PNNL through funding by the National Nuclear Security Administration Office of Nuclear Verification over the past few years. The objective of this work is to allow monitors to have confidence in both the authenticity and integrity of the TIE and the monitoring equipment inside, throughout the time it may be located at a host facility. Incorporating authentication features into the design were the focus of fiscal year 2014 development efforts. Throughout the development process, modifications have been made to the physical TIE design based on lessons learned via exercises and expert elicitation. The end result is a robust and passive TIE which can be utilized to protect monitoring party equipment left in a host facility.

Method for statistical data analysis of multivariate observations

CERN Document Server

Gnanadesikan, R

1997-01-01

A practical guide for multivariate statistical techniques-- now updated and revised In recent years, innovations in computer technology and statistical methodologies have dramatically altered the landscape of multivariate data analysis. This new edition of Methods for Statistical Data Analysis of Multivariate Observations explores current multivariate concepts and techniques while retaining the same practical focus of its predecessor. It integrates methods and data-based interpretations relevant to multivariate analysis in a way that addresses real-world problems arising in many areas of inte

Advances in statistical models for data analysis

CERN Document Server

Minerva, Tommaso; Vichi, Maurizio

2015-01-01

This edited volume focuses on recent research results in classification, multivariate statistics and machine learning and highlights advances in statistical models for data analysis. The volume provides both methodological developments and contributions to a wide range of application areas such as economics, marketing, education, social sciences and environment. The papers in this volume were first presented at the 9th biannual meeting of the Classification and Data Analysis Group (CLADAG) of the Italian Statistical Society, held in September 2013 at the University of Modena and Reggio Emilia, Italy.

Analysis of the tractive force pattern on a knot by force measurement during laparoscopic knot tying.

Science.gov (United States)

Takayasu, Kenta; Yoshida, Kenji; Kinoshita, Hidefumi; Yoshimoto, Syunsuke; Oshiro, Osamu; Matsuda, Tadashi

2017-07-19

Quantifying surgical skills assists novice surgeons when learning operative techniques. We measured the interaction force at a ligation point and clarified the features of the force pattern among surgeons with different skill levels during laparoscopic knot tying. Forty-four surgeons were divided into three groups based on experience: 13 novice (0-5 years), 16 intermediate (6-15 years), and 15 expert (16-30 years). To assess the tractive force direction and volume during knot tying, we used a sensor that measures six force-torque values (x-axis: Fx, y-axis: Fy, z-axis: Fz, and xy-axis: Fxy) attached to a slit Penrose drain. All participants completed one double knot and five single knot sequences. We recorded completion time, force volume (FV), maximum force (MF), time over 1.5 N, duration of non-zero force, and percentage time when vertical force exceeded horizontal force (PTz). There was a significant difference between groups for completion time (p = 0.007); FV (total: p = 0.002; Fx: p = 0.004, Fy: p = 0.007, Fxy: p = 0.004, Fz: p force (p = 0.029); and PTz (p force pattern at the ligation point during suturing by surgeons with three levels of experience using a force measurement system. We revealed that both force volume and force direction differed depending on surgeons' skill level during knot tying. Copyright © 2017. Published by Elsevier Inc.

A Synchronization Method for Single-Phase Grid-Tied Inverters

DEFF Research Database (Denmark)

Hadjidemetriou, Lenos; Kyriakides, Elias; Yang, Yongheng

2016-01-01

The controllers of single-phase grid-tied inverters require improvements to enable distribution generation systems to meet the grid codes/standards with respect to power quality and the fault ride through capability. In that case, the response of the selected synchronization technique is crucial...... for the performance of the entire grid-tied inverter. In this paper, a new synchronization method with good dynamics and high accuracy under a highly distorted voltage is proposed. This method uses a Multi-Harmonic Decoupling Cell (MHDC), which thus can cancel out the oscillations on the synchronization signals due...... to the harmonic voltage distortion while maintaining the dynamic response of the synchronization. Therefore, the accurate and dynamic response of the proposed MHDC-PLL can be beneficial for the performance of the whole single-phase grid-tied inverter....

Ties that Blind: Perpetuation of Racial Comfort and Discomfort at a Community College

Science.gov (United States)

Price, Douglas B.; Hyle, Adrienne E.; Jordan, Kitty V.

2009-01-01

Interviews with 17 African American students and 19 White students were employed to examine interracial relations at a predominantly White community college campus. Seen through the lens of Granovetter's strength of ties theory, the interview findings revealed that strong intraracial ties and the absence of weak interracial ties inhibited…

Passivity Enhancement of Grid-Tied Converter by Series LC-Filtered Active Damper

DEFF Research Database (Denmark)

Bai, Haofeng; Wang, Xiongfei; Loh, Poh Chiang

2015-01-01

attention. Also, parasitic capacitance of the grid transmission line brings new challenge for the application of an active damper, which has not been discussed before. In order to fill these gaps, this paper first analyzes the stability of a grid-tied converter with the help of passivity. Based......Series LC-filtered active damper can be used to stabilize the grid-tied voltage source converter in a non-ideal grid. The operation principle of the active damper is to mimic a damping resistance at the resonance frequencies. However, the selection of the damping resistance has not received much...... on the passivity-based-stability analysis, a damping resistance selection method is proposed. Then, an admittance shaping method is developed to ensure the system stability in the presence of parasitic capacitance of the transmission line. Finally, experimental results are provided to show the validity...

Dairy cows welfare quality in tie-stall housing system with or without access to exercise

Science.gov (United States)

2013-01-01

Background Tie-stall housing of dairy cows is used extensively worldwide, despite of the welfare concerns regarding the restriction of voluntary movement and limitation of expression of the cows’ natural behaviour. The aim of this study was to compare the welfare quality of dairy cows kept in two types of tie-stall housing systems: with regular outdoor exercise and without access to exercise. In addition, the study investigated the relationship between different welfare measures of dairy cows kept in tie-stalls. Methods 3,192 lactating cows were assessed using the Welfare Quality® assessment protocol for cattle in 80 commercial dairy farms, half of the farms providing outdoor access for the animals to exercise. The descriptive statistical indicators were determined for the assessed measures and for the welfare criteria and principle scores. The data obtained in the two housing types were compared and the correlation coefficients were calculated between the different welfare measures. Results The significant differences found between the two housing systems for the majority of the animal based measures indicate the positive effect of exercise on the welfare of tethered cows. Many of the animal welfare parameters correlated with each other. For the farms allowing the cows’ turnout in a paddock, pasture or both, the mean scores for the welfare criteria and principles were higher than for the farms with permanent tethering of the cows, except the criteria absence of prolonged hunger and expression of social behaviours. The lowest scores were obtained for the criterion positive emotional state, in both housing systems. With regard to the overall classification, none of the farms were considered excellent. In the not classified category were only farms with all-year-round tethering of the animals and in the enhanced category only farms where the cows had outdoor access. Conclusions The welfare quality of the investigated dairy cows was significantly better in the

Four- year thyroidectomy procedures: Ligasure Vs. clamp & tie

Directory of Open Access Journals (Sweden)

Pazoki AR

2010-01-01

Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: The electrothermal bipolar vessel sealing system is an adjunct to the hemostatic technique, which has been successfully used in many abdominal operation, recently made available to thyroid surgery. The purpose of this was compare the outcomes of new hemostatic technique with traditional method of clamp and tie."n"nMethods: In this retrospective cross-sectional study has been done in surgery's wards of Milad & Rasul- Akram hospitals in Tehran, Iran. During three- year period between 2005-2008 all patients with different kind of pathology that need operation were assessed. Time duration of surgery and hospital stay and post surgery complication in two group, ligasure (n=45 and clamp & tie (n=145 were compared with each others."n"nResults: No difference was seen between two groups in time duration of surgery. Significant difference was seen in hospital stay and complications of surgery. Time of operation in Ligasure group was 132/22 minute and in clamp and tie group was 130/10 minute. There was found significant difference in duration of hospital stay and postoperative complication. Hypocalcemia were seen in two and 24 cases in Ligasure and Clamp & Tie group, respectively (p<0.05. Hospital stay was 2

Analysis and Comparison of Si and SiC Power Devices on a Grid-Tie Fuel Cell Energy Storage System

DEFF Research Database (Denmark)

Pittini, Riccardo; Anthon, Alexander; Zhang, Zhe

2014-01-01

In renewable energy applications power conversion efficiency is major concern. This is especially true for grid-tie energy storage systems based on bidirectional dc-dc and dc-ac converters where power flows through these system components. Latest developments in power semiconductors technology......-tie energy storage systems. Results highlight dc-dc conversion efficiencies up to 98.2% with an isolated topology and dc-ac conversion efficiencies up to 97.7%. Overall system efficiency improvements above 1% are achieved compared to traditional Si devices. Results on efficiency improvement are analyzed...

Additional vibration investigations on the prestressed tie rods attaching the no.1 lives team line clamps to the concrete structures at Paluel-1

International Nuclear Information System (INIS)

Guihot, P.; Le Picard, J.P.

1993-12-01

This test report presents vibration analysis results obtained on the prestressed tie rods attaching the N. 1 live steam line clamps to the concrete structures of the PALUEL-1 unit. The purpose of these tests was to assess the feasibility of using a vibration analysis to determine the effective prestress level in the tie rods. The previous investigations performed with an impact hammer yielded no definite conclusions as to the feasibility of the method. The new series of tests, performed with a sinusoidal scanning electro-dynamic exciter, gave far more accurate results. However, the eigenfrequencies characterizing the tie rod tension level were not evidenced. It would consequently not seem possible to identify the tightening level by monitoring the first resonant frequency with the equipment installed. There are alternative solutions, such as keeping the same principle and substantially increasing the excitation levels, thereby precluding a head and foot restraint response from the tie rod, or using an ultrasonic method. (authors). 2 figs., 3 refs., 2 annexes

Small-Signal Analysis of Autonomous Hybrid Distributed Generation Systems in Presence of Ultracapacitor and Tie-Line Operation

Science.gov (United States)

Ray, Prakash K.; Mohanty, Soumya R.; Kishor, Nand

2010-07-01

This paper presents small-signal analysis of isolated as well as interconnected autonomous hybrid distributed generation system for sudden variation in load demand, wind speed and solar radiation. The hybrid systems comprise of different renewable energy resources such as wind, photovoltaic (PV) fuel cell (FC) and diesel engine generator (DEG) along with the energy storage devices such as flywheel energy storage system (FESS) and battery energy storage system (BESS). Further ultracapacitors (UC) as an alternative energy storage element and interconnection of hybrid systems through tie-line is incorporated into the system for improved performance. A comparative assessment of deviation of frequency profile for different hybrid systems in the presence of different storage system combinations is carried out graphically as well as in terms of the performance index (PI), ie integral square error (ISE). Both qualitative and quantitative analysis reflects the improvements of the deviation in frequency profiles in the presence of the ultracapacitors (UC) as compared to other energy storage elements.

Statistical models and methods for reliability and survival analysis

CERN Document Server

Couallier, Vincent; Huber-Carol, Catherine; Mesbah, Mounir; Huber -Carol, Catherine; Limnios, Nikolaos; Gerville-Reache, Leo

2013-01-01

Statistical Models and Methods for Reliability and Survival Analysis brings together contributions by specialists in statistical theory as they discuss their applications providing up-to-date developments in methods used in survival analysis, statistical goodness of fit, stochastic processes for system reliability, amongst others. Many of these are related to the work of Professor M. Nikulin in statistics over the past 30 years. The authors gather together various contributions with a broad array of techniques and results, divided into three parts - Statistical Models and Methods, Statistical

Classification, (big) data analysis and statistical learning

CERN Document Server

Conversano, Claudio; Vichi, Maurizio

2018-01-01

This edited book focuses on the latest developments in classification, statistical learning, data analysis and related areas of data science, including statistical analysis of large datasets, big data analytics, time series clustering, integration of data from different sources, as well as social networks. It covers both methodological aspects as well as applications to a wide range of areas such as economics, marketing, education, social sciences, medicine, environmental sciences and the pharmaceutical industry. In addition, it describes the basic features of the software behind the data analysis results, and provides links to the corresponding codes and data sets where necessary. This book is intended for researchers and practitioners who are interested in the latest developments and applications in the field. The peer-reviewed contributions were presented at the 10th Scientific Meeting of the Classification and Data Analysis Group (CLADAG) of the Italian Statistical Society, held in Santa Margherita di Pul...

Statistical hot spot analysis of reactor cores

International Nuclear Information System (INIS)

Schaefer, H.

1974-05-01

This report is an introduction into statistical hot spot analysis. After the definition of the term 'hot spot' a statistical analysis is outlined. The mathematical method is presented, especially the formula concerning the probability of no hot spots in a reactor core is evaluated. A discussion with the boundary conditions of a statistical hot spot analysis is given (technological limits, nominal situation, uncertainties). The application of the hot spot analysis to the linear power of pellets and the temperature rise in cooling channels is demonstrated with respect to the test zone of KNK II. Basic values, such as probability of no hot spots, hot spot potential, expected hot spot diagram and cumulative distribution function of hot spots, are discussed. It is shown, that the risk of hot channels can be dispersed equally over all subassemblies by an adequate choice of the nominal temperature distribution in the core

The statistical analysis of anisotropies

International Nuclear Information System (INIS)

Webster, A.

1977-01-01

One of the many uses to which a radio survey may be put is an analysis of the distribution of the radio sources on the celestial sphere to find out whether they are bunched into clusters or lie in preferred regions of space. There are many methods of testing for clustering in point processes and since they are not all equally good this contribution is presented as a brief guide to what seems to be the best of them. The radio sources certainly do not show very strong clusering and may well be entirely unclustered so if a statistical method is to be useful it must be both powerful and flexible. A statistic is powerful in this context if it can efficiently distinguish a weakly clustered distribution of sources from an unclustered one, and it is flexible if it can be applied in a way which avoids mistaking defects in the survey for true peculiarities in the distribution of sources. The paper divides clustering statistics into two classes: number density statistics and log N/log S statistics. (Auth.)

Basic statistical tools in research and data analysis

Directory of Open Access Journals (Sweden)

Zulfiqar Ali

2016-01-01

Full Text Available Statistical methods involved in carrying out a study include planning, designing, collecting data, analysing, drawing meaningful interpretation and reporting of the research findings. The statistical analysis gives meaning to the meaningless numbers, thereby breathing life into a lifeless data. The results and inferences are precise only if proper statistical tests are used. This article will try to acquaint the reader with the basic research tools that are utilised while conducting various studies. The article covers a brief outline of the variables, an understanding of quantitative and qualitative variables and the measures of central tendency. An idea of the sample size estimation, power analysis and the statistical errors is given. Finally, there is a summary of parametric and non-parametric tests used for data analysis.

Leaving Libertarianism: : Social Ties in Robert Nozick's New Philosophy

OpenAIRE

Herbjørnsrud, Dag

2002-01-01

SUMMARY This thesis Leaving Libertarianism: Social Ties in Robert Nozick s New Philosophy challenges the general and most widespread portrayals of the American philosopher Robert Nozick (1938-2002) by studying the notion of social ties in his later philosophy. The point of departure is the present descriptions of Nozick s philosophy. Mostly these depictions are based upon three postulates: That Nozick is an extreme individualist, that the libertarian Anarchy, State, and Utopia (1...

Reproducible statistical analysis with multiple languages

DEFF Research Database (Denmark)

Lenth, Russell; Højsgaard, Søren

2011-01-01

This paper describes the system for making reproducible statistical analyses. differs from other systems for reproducible analysis in several ways. The two main differences are: (1) Several statistics programs can be in used in the same document. (2) Documents can be prepared using OpenOffice or ......Office or \\LaTeX. The main part of this paper is an example showing how to use and together in an OpenOffice text document. The paper also contains some practical considerations on the use of literate programming in statistics....

A better way to teach knot tying: a randomized controlled trial comparing the kinesthetic and traditional methods.

Science.gov (United States)

Huang, Emily; Chern, Hueylan; O'Sullivan, Patricia; Cook, Brian; McDonald, Erik; Palmer, Barnard; Liu, Terrence; Kim, Edward

2014-10-01

Knot tying is a fundamental and crucial surgical skill. We developed a kinesthetic pedagogical approach that increases precision and economy of motion by explicitly teaching suture-handling maneuvers and studied its effects on novice performance. Seventy-four first-year medical students were randomized to learn knot tying via either the traditional or the novel "kinesthetic" method. After 1 week of independent practice, students were videotaped performing 4 tying tasks. Three raters scored deidentified videos using a validated visual analog scale. The groups were compared using analysis of covariance with practice knots as a covariate and visual analog scale score (range, 0 to 100) as the dependent variable. Partial eta-square was calculated to indicate effect size. Overall rater reliability was .92. The kinesthetic group scored significantly higher than the traditional group for individual tasks and overall, controlling for practice (all P kinesthetic overall mean was 64.15 (standard deviation = 16.72) vs traditional 46.31 (standard deviation = 16.20; P kinesthetic suture handling substantively improved performance on knot tying. We believe this effect can be extrapolated to more complex surgical skills. Copyright © 2014 Elsevier Inc. All rights reserved.

Social Tie Strength and Online Victimization: An Analysis of Young People Aged 15–30 Years in Four Nations

Directory of Open Access Journals (Sweden)

Teo Keipi

2017-01-01

Full Text Available Online interaction through the use of social networking sites (SNS continues to be a significant component of the socialization of young people today, yet little research exists toward linking various relational forms to prevalent and much-studied online risks cross-nationally. This article provides a link between relational dynamics and online risks identified in previous research toward a new perspective on how social tie strength is related to experiences of hate victimization and harassment online. The analysis is based on survey data of Finnish ( n  = 555, American ( n  = 1033, German ( n  = 978, and British ( n  = 999 young people aged 15–30 years. Variables, including age, gender, main activity, SNS use, quantity, and extent of online and offline social networks including social tie strength and online community identification, were analyzed toward finding their associations with online hate victimization and harassment. Results showed that experiences of hate victimization and harassment were similar cross-nationally and that those who were personally harassed online also reported high SNS activity. Furthermore, no association was found between social network size and negative experiences. Notable cross-national differences were also detected in the results. Findings emphasize the importance of understanding variables fostering online risks for young people while providing a new perspective on what aspects of social life may help negate negative effects online.

Importance of tie strengths in the prisoner's dilemma game on social networks

Energy Technology Data Exchange (ETDEWEB)

Xu, Bo, E-mail: xubosuper@163.com [Department of Information Systems, School of Economics and Management, Beihang University (China); Liu, Lu; You, Weijia [Department of Information Systems, School of Economics and Management, Beihang University (China)

2011-06-13

Though numerous researches have shown that tie strengths play a key role in the formation of collective behavior in social networks, little work has been done to explore their impact on the outcome of evolutionary games. In this Letter, we studied the effect of tie strength in the dynamics of evolutionary prisoner's dilemma games by using online social network datasets. The results show that the fraction of cooperators has a non-trivial dependence on tie strength. Weak ties, just like previous researches on epidemics and information diffusion have shown, play a key role by the maintenance of cooperators in evolutionary prisoner's dilemma games. -- Highlights: → Tie strength is used to measure heterogeneous influences of different pairs of nodes. → Weak ties play a role in maintaining cooperation in prisoner's dilemma games. → Micro-dynamics of nodes are illustrated to explain the conclusion.

Finite element analyses of continuous filament ties for masonry applications : final report for the Arquin Corporation.

Energy Technology Data Exchange (ETDEWEB)

Quinones, Armando, Sr. (Arquin Corporation, La Luz, NM); Bibeau, Tiffany A.; Ho, Clifford Kuofei

2008-08-01

Finite-element analyses were performed to simulate the response of a hypothetical vertical masonry wall subject to different lateral loads with and without continuous horizontal filament ties laid between rows of concrete blocks. A static loading analysis and cost comparison were also performed to evaluate optimal materials and designs for the spacers affixed to the filaments. Results showed that polypropylene, ABS, and polyethylene (high density) were suitable materials for the spacers based on performance and cost, and the short T-spacer design was optimal based on its performance and functionality. Simulations of vertical walls subject to static loads representing 100 mph winds (0.2 psi) and a seismic event (0.66 psi) showed that the simulated walls performed similarly and adequately when subject to these loads with and without the ties. Additional simulations and tests are required to assess the performance of actual walls with and without the ties under greater loads and more realistic conditions (e.g., cracks, non-linear response).

Common pitfalls in statistical analysis: "P" values, statistical significance and confidence intervals

Directory of Open Access Journals (Sweden)

Priya Ranganathan

2015-01-01

Full Text Available In the second part of a series on pitfalls in statistical analysis, we look at various ways in which a statistically significant study result can be expressed. We debunk some of the myths regarding the ′P′ value, explain the importance of ′confidence intervals′ and clarify the importance of including both values in a paper

78 FR 75545 - Prestressed Concrete Steel Rail Tie Wire From the People's Republic of China: Preliminary...

Science.gov (United States)

2013-12-12

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-990] Prestressed Concrete Steel... (``Department'') preliminarily determines that prestressed concrete steel rail tie wire (``PC tie wire'') from... prestressed tendons in concrete railroad ties (``PC tie wire''). High carbon steel is defined as steel that...

Peer monitoring, social ties and moral hazard in group lending programmes : evidence from Eritrea

NARCIS (Netherlands)

Hermes, C.L.M.; Lensink, B.W.; Mehrteab, H.T.

2003-01-01

In this paper, we provide an empirical analysis of the impact of monitoring and social ties within group lending programs on moral hazard behavior of its participants, based on data from an extensive questionnaire held in Eritrea among participants of 102 groups. We find support for the fact that

Cross-border Ties as Sources of Risk and Resilience: Do Cross-border Ties Moderate the Relationship between Migration-related Stress and Psychological Distress for Latino Migrants in the United States?

Science.gov (United States)

Torres, Jacqueline M; Alcántara, Carmela; Rudolph, Kara E; Viruell-Fuentes, Edna A

2016-12-01

Few studies have examined the associations between health and the cross-border ties that migrants maintain with their family members in communities of origin. We draw on theory related to social ties, ethnic identity, and mental health to examine cross-border ties as potential moderators of the association between migration-related stress and psychological distress among Latino migrants. Using data from the National Latino and Asian American Survey, we find that remittance sending is associated with significantly lower levels of psychological distress for Cuban migrants, and difficulty visiting home is associated with significantly greater psychological distress for Puerto Rican migrants. There were significant associations between migration-related stressors and psychological distress, although these associations fell to nonsignificance after accounting for multiple testing. We found little evidence that cross-border ties either buffer or exacerbate the association between migration-related stressors and psychological distress. We consider the findings within the current political and historical context of cross-border ties and separation. © American Sociological Association 2016.

Statistics and analysis of scientific data

CERN Document Server

Bonamente, Massimiliano

2017-01-01

The revised second edition of this textbook provides the reader with a solid foundation in probability theory and statistics as applied to the physical sciences, engineering and related fields. It covers a broad range of numerical and analytical methods that are essential for the correct analysis of scientific data, including probability theory, distribution functions of statistics, fits to two-dimensional data and parameter estimation, Monte Carlo methods and Markov chains. Features new to this edition include: • a discussion of statistical techniques employed in business science, such as multiple regression analysis of multivariate datasets. • a new chapter on the various measures of the mean including logarithmic averages. • new chapters on systematic errors and intrinsic scatter, and on the fitting of data with bivariate errors. • a new case study and additional worked examples. • mathematical derivations and theoretical background material have been appropriately marked,to improve the readabili...

Statistical evaluation of diagnostic performance topics in ROC analysis

CERN Document Server

Zou, Kelly H; Bandos, Andriy I; Ohno-Machado, Lucila; Rockette, Howard E

2016-01-01

Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medi...

Ties that bind: multiple relationships between clinical researchers and the pharmaceutical industry.

Science.gov (United States)

Henry, David; Doran, Evan; Kerridge, Ian; Hill, Suzanne; McNeill, Paul M; Day, Richard

2005-11-28

It is believed that pharmaceutical industry sponsorship of clinical research leads to the development of multiple ties between clinicians and the pharmaceutical industry. To quantify this relationship we conducted a survey of medical specialists listed in the Medical Directory of Australia in 2002 and 2003. A questionnaire was mailed that elicited information about all aspects of research relationships between clinicians and pharmaceutical companies. The odds of reporting multiple additional ties (financial and professional) with pharmaceutical companies by clinicians who had an active research relationship were compared with those who did not. All clinicians who returned a completed questionnaire about their research activities were included in the study. A questionnaire was mailed to 2120 medical specialists; 823 (39%) responded. Of these, 338 (41%) reported involvement in industry-sponsored research in the previous year. They were more likely than others to have been offered industry-sponsored items or activities valued at more than 500 AU dollars (>382 US dollars; odds ratio [OR], 3.5; 95% confidence interval [CI], 2.6-4.7) and support for attending international conferences (OR, 5.4; 95% CI, 3.9-7.4). The strongest associations were seen for acting as a paid consultant to industry (OR, 9.0; 95% CI, 3.9-20.4) and for membership on advisory boards (OR, 6.9; 95% CI, 5.1-9.6). There was a strong relationship between research collaboration and accumulation of industry ties. For 1 additional tie the OR was 2.2 (95% CI, 1.2-3.8) and rose to 6.3 (95% CI, 3.5-11.1) with 3 ties and 41.8 (95% CI, 14.5-143.4) with 6 or more ties. Medical specialists who have research relationships with the pharmaceutical industry are much more likely to have multiple additional ties than those who do not have research relationships. Institutional review should discourage clinical researchers from developing multiple ties.

Bayesian Inference in Statistical Analysis

CERN Document Server

Box, George E P

2011-01-01

The Wiley Classics Library consists of selected books that have become recognized classics in their respective fields. With these new unabridged and inexpensive editions, Wiley hopes to extend the life of these important works by making them available to future generations of mathematicians and scientists. Currently available in the Series: T. W. Anderson The Statistical Analysis of Time Series T. S. Arthanari & Yadolah Dodge Mathematical Programming in Statistics Emil Artin Geometric Algebra Norman T. J. Bailey The Elements of Stochastic Processes with Applications to the Natural Sciences Rob

Multivariate Statistics and Supervised Learning for Predictive Detection of Unintentional Islanding in Grid-Tied Solar PV Systems

Directory of Open Access Journals (Sweden)

Shashank Vyas

2016-01-01

Full Text Available Integration of solar photovoltaic (PV generation with power distribution networks leads to many operational challenges and complexities. Unintentional islanding is one of them which is of rising concern given the steady increase in grid-connected PV power. This paper builds up on an exploratory study of unintentional islanding on a modeled radial feeder having large PV penetration. Dynamic simulations, also run in real time, resulted in exploration of unique potential causes of creation of accidental islands. The resulting voltage and current data underwent dimensionality reduction using principal component analysis (PCA which formed the basis for the application of Q statistic control charts for detecting the anomalous currents that could island the system. For reducing the false alarm rate of anomaly detection, Kullback-Leibler (K-L divergence was applied on the principal component projections which concluded that Q statistic based approach alone is not reliable for detection of the symptoms liable to cause unintentional islanding. The obtained data was labeled and a K-nearest neighbor (K-NN binomial classifier was then trained for identification and classification of potential islanding precursors from other power system transients. The three-phase short-circuit fault case was successfully identified as statistically different from islanding symptoms.

Analysis of Variance: What Is Your Statistical Software Actually Doing?

Science.gov (United States)

Li, Jian; Lomax, Richard G.

2011-01-01

Users assume statistical software packages produce accurate results. In this article, the authors systematically examined Statistical Package for the Social Sciences (SPSS) and Statistical Analysis System (SAS) for 3 analysis of variance (ANOVA) designs, mixed-effects ANOVA, fixed-effects analysis of covariance (ANCOVA), and nested ANOVA. For each…

EXPORT PROMOTION: Export-Import Bank and Treasury Differ in Their Approaches to Using Tied Aid

National Research Council Canada - National Science Library

2002-01-01

Under the tied aid program legislation,4 Treasury had the authority to direct and control the use of Ex-Im Bank's Tied Aid Capital Projects Fund, in effect allowing Treasury to veto individual tied aid proposals...

Comparing Visual and Statistical Analysis of Multiple Baseline Design Graphs.

Science.gov (United States)

Wolfe, Katie; Dickenson, Tammiee S; Miller, Bridget; McGrath, Kathleen V

2018-04-01

A growing number of statistical analyses are being developed for single-case research. One important factor in evaluating these methods is the extent to which each corresponds to visual analysis. Few studies have compared statistical and visual analysis, and information about more recently developed statistics is scarce. Therefore, our purpose was to evaluate the agreement between visual analysis and four statistical analyses: improvement rate difference (IRD); Tau-U; Hedges, Pustejovsky, Shadish (HPS) effect size; and between-case standardized mean difference (BC-SMD). Results indicate that IRD and BC-SMD had the strongest overall agreement with visual analysis. Although Tau-U had strong agreement with visual analysis on raw values, it had poorer agreement when those values were dichotomized to represent the presence or absence of a functional relation. Overall, visual analysis appeared to be more conservative than statistical analysis, but further research is needed to evaluate the nature of these disagreements.

Sensitivity analysis and related analysis : A survey of statistical techniques

NARCIS (Netherlands)

Kleijnen, J.P.C.

1995-01-01

This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type of analysis be applied; which statistical

Influence of ties on the behavior of short reinforced concrete columns strengthened by external CFRP

Directory of Open Access Journals (Sweden)

Sarsam Kaiss

2018-01-01

Full Text Available An experimental study was carried out to investigate the behavior of normal strength reinforce concret (RC circular short column strengthned with “carbon fiber reinforced polymer (CFRP sheets”. Three series comprising totally of (15 specimens loaded until failure under concentric compresion load. Strengthening was varied by changing the number of CFRP strips, spacing and wrapping methods. The findings of this research can be summarized as follows: for the columns without CFRP, the influence of the tie spacing was significant: compared with 130 mm tie spacing, dropping the spacing to 100 mm and 70 mm increased the load carrying capacity by 18% and 26%, respectively. The columns with less internal confinement (lesser amount of ties were strengthened more significantly by the CFRP than the ones with greater amount of internal ties. As an example of the varying effectiveness of the fully wrapped CFRP, the column with ties at 130 mm was strengthened by 90% with the CFRP. In contrast, the ones with 70 mm spaced ties only increased in strength with CFRP by 66%. Compared with the control specimen (no CFRP, the same amount of CFRP when used as hoop strips led to more strengthening than using CFRP as a spiral strip- the former led to nearly 9% more strengthening than the latter in the case of 130 mm spaced internal steel ties. In the case of 100 mm internal steel ties, the difference (between the hoops & spiral CFRP strengthening is close to 4%. In contrast, there is no difference between the two methods of strengthening in the heavily tied columns (70 mm tied spacing.

Mathematical Ties That Bind.

Science.gov (United States)

House, Peggy A.

1994-01-01

Describes some mathematical investigations of the necktie which includes applications of geometry, statistics, data analysis, sampling, probability, symmetry, proportion, problem solving, and business. (MKR)

Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis.

Directory of Open Access Journals (Sweden)

Rita Campanelli

Full Text Available Primary myelofibrosis (PMF is a Philadelphia-negative (Ph- myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. Monocytes expressing the angiopoietin-2 receptor (Tie2 have been shown to support abnormal angiogenic processes in solid tumors through a paracrine action that takes place in proximity to the vessels. In this study we investigated the frequency of Tie2 expressing monocytes in the spleen tissue samples of patients with PMF, and healthy subjects (CTRLs, and evaluated their possible role in favouring spleen angiogenesis. We show by confocal microscopy that in the spleen tissue of patients with PMF, but not of CTRLs, the most of the CD14+ cells are Tie2+ and are close to vessels; by flow cytometry, we found that Tie2 expressing monocytes were Tie2+CD14lowCD16brightCDL62-CCR2- (TEMs and their frequency was higher (p = 0.008 in spleen tissue-derived mononuclear cells (MNCs of patients with PMF than in spleen tissue-derived MNCs from CTRLs undergoing splenectomy for abdominal trauma. By in vitro angiogenesis assay we evidenced that conditioned medium of immunomagnetically selected spleen tissue derived CD14+ cells of patients with PMF induced a denser tube like net than that of CTRLs; in addition, CD14+Tie2+ cells sorted from spleen tissue derived single cell suspension of patients with PMF show a higher expression of genes involved in angiogenesis than that found in CTRLs. Our results document the enrichment of Tie2+ monocytes expressing angiogenic genes in the spleen of patients with PMF, suggesting a role for these cells in starting/maintaining the pathological angiogenesis in this organ.

Fractionated BNCT for locally recurrent head and neck cancer: Experience from a phase I/II clinical trial at Tsing Hua Open-Pool Reactor

International Nuclear Information System (INIS)

Wang, Ling-Wei; Chen, Yi-Wei; Ho, Ching-Yin; Hsueh Liu, Yen-Wan; Chou, Fong-In; Liu, Yuan-Hao; Liu, Hong-Ming; Peir, Jinn-Jer; Jiang, Shiang-Huei; Chang, Chi-Wei; Liu, Ching-Sheng; Wang, Shyh-Jen; Chu, Pen-Yuan; Yen, Sang-Hue

2014-01-01

To introduce our experience of treating locally and regionally recurrent head and neck cancer patients with BNCT at Tsing Hua Open-Pool Reactor in Taiwan, 12 patients (M/F=10/2, median age 55.5 Y/O) were enrolled and 11 received two fractions of treatment. Fractionated BNCT at 30-day interval with adaptive planning according to changed T/N ratios was feasible, effective and safe for selected recurrent head and neck cancer in this trial. - Highlights: • We treated 12 patients with recurrent Head and Neck (H and N) cancer after radical surgery and radiotherapy since 2010. • Four complete response (CR) and 3 partial response (PR) were found. Total response rate was 58%. • Two patients had local control longer than one year. • No grade 4 or higher toxicity was noted for both acute and chronic effects

Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori.

Science.gov (United States)

Devi, Savita; Ansari, Suhail A; Tenguria, Shivendra; Kumar, Naveen; Ahmed, Niyaz

2016-11-02

Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stress and post adherence to gastric epithelial cells. Studies with isogenic knockouts of tieA revealed it to be a secretory protein which translocates into the host gastric epithelial cells independent of a type IV secretion system, gets phosphorylated by DNA-PK kinase and auto-phosphorylates as serine kinase. Furthermore, TieA binds to and cleaves DNA in a non-specific manner and promotes Fas mediated apoptosis in AGS cells. Additionally, TieA induced pro-inflammatory cytokine secretion via activation of transcription factor AP-1 and signaled through MAP kinase pathway. Collectively, TieA with its multipronged and moonlighting functions could facilitate H. pylori in maintaining a balance of bacterial adaptation, and elimination by the host responses. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Cross-border ties as a source of risk and resilience: Do cross-border ties moderate the relationship between migration-related stress and psychological distress among Latino migrants in the United States?

Science.gov (United States)

Torres, Jacqueline M.; Alcántara, Carmela; Rudolph, Kara E.; Viruell-Fuentes, Edna A.

2017-01-01

Few studies have examined the associations between health and the cross-border ties that migrants maintain with their family members in communities of origin. We draw on theory related to social ties, ethnic identity, and mental health to examine cross-border ties as potential moderators of the association between migration-related stress and psychological distress among Latino migrants. Using data from the National Latino and Asian American Survey, we find that remittance sending is associated with significantly lower levels of psychological distress for Cuban migrants, and difficulty visiting home is associated with significantly greater psychological distress for Puerto Rican migrants. There were significant associations between migration-related stressors and psychological distress, although these associations fell to non-significance after accounting for multiple testing. We found little evidence that cross-border ties either buffer or exacerbate the association between migration-related stressors and psychological distress. We consider the findings within the current political and historical context of cross-border ties and separation. PMID:27803264

Endothelial Activation: The Ang/Tie Axis in Sepsis

Directory of Open Access Journals (Sweden)

Aleksandra Leligdowicz

2018-04-01

Full Text Available Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis can be caused by a wide variety of pathogenic organisms, endothelial dysfunction leading to vascular leak is a common mechanism of injury that contributes to the morbidity and mortality associated with the syndrome. Perturbations to the angiopoietin (Ang/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis. In this review, we summarize how the Ang/Tie2 pathway is implicated in sepsis and describe its prognostic as well as therapeutic utility in life-threatening infections.

TIES for Dummies 3rd Edition (Technology Identification, Evaluation, and Selection) Basic how to's to implement the TIES method

Science.gov (United States)

Kirby, Michelle R.

2002-01-01

The TIES method is a forecasting environment whereby the decision-maker has the ability to easily assess and trade-off the impact of various technologies without sophisticated and time-consuming mathematical formulations. TIES provides a methodical approach where technically feasible alternatives can be identified with accuracy and speed to reduce design cycle time, and subsequently, life cycle costs, and was achieved through the use of various probabilistic methods, such as Response Surface Methodology and Monte Carlo Simulations. Furthermore, structured and systematic techniques are utilized from other fields to identify possible concepts and evaluation criteria by which comparisons can be made. This objective is achieved by employing the use of Morphological Matrices and Multi-Attribute Decision Making techniques. Through the execution of each step, a family of design alternatives for a given set of customer requirements can be identified and assessed subjectively or objectively. This methodology allows for more information (knowledge) to be brought into the earlier phases of the design process and will have direct implications on the affordability of the system. The increased knowledge allows for optimum allocation of company resources and quantitative justification for program decisions. Finally, the TIES method provided novel results and quantitative justification to facilitate decision making in the early stages of design so as to produce affordable and quality products.

High-speed passenger rail tie-ballast interaction.

Science.gov (United States)

2015-05-01

This Research Results Report presents : evidence of poor tie support and increased : applied loads that were used to determine the : root cause of transient and permanent vertical : displacements at two Amtrak bridge transitions. : These result...

Magnetic perturbations seen by CHAMP and evaluated using the TIE-GCM

Directory of Open Access Journals (Sweden)

D. T. Mozzoni

2007-07-01

Full Text Available The Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIE-GCM is a self-consistent, global, atmospheric model that can be used to estimate magnetic perturbations at satellite altitude. These computed perturbations can then be compared with the magnetic vector data provided by low-earth orbiting satellites. In this initial study, the quietest day of each month from 2001–2005 was selected for comparison. CHAMP magnetic vector residuals were computed for these intervals using the CHAOS model to remove core and crustal geomagnetic contributions. Under various input parameters, the TIE-GCM predictions were compared with the CHAMP residuals on an orbit by orbit basis. Initial results demonstrate a reasonable agreement between the TIE-GCM estimates and the CHAMP residuals in non-polar, dayside regions (±50° magnetic latitude where both are able to resolve the Equatorial Electro-Jet (EEJ and solar quiet (Sq current systems. Although no clear component or temporal correlation was discerned, evidence showing the decrease in residual comparisons presents the possibility of using the TIE-GCM to pre-process geomagnetic data for main field modeling purposes.

Online Statistical Modeling (Regression Analysis) for Independent Responses

Science.gov (United States)

Made Tirta, I.; Anggraeni, Dian; Pandutama, Martinus

2017-06-01

Regression analysis (statistical analmodelling) are among statistical methods which are frequently needed in analyzing quantitative data, especially to model relationship between response and explanatory variables. Nowadays, statistical models have been developed into various directions to model various type and complex relationship of data. Rich varieties of advanced and recent statistical modelling are mostly available on open source software (one of them is R). However, these advanced statistical modelling, are not very friendly to novice R users, since they are based on programming script or command line interface. Our research aims to developed web interface (based on R and shiny), so that most recent and advanced statistical modelling are readily available, accessible and applicable on web. We have previously made interface in the form of e-tutorial for several modern and advanced statistical modelling on R especially for independent responses (including linear models/LM, generalized linier models/GLM, generalized additive model/GAM and generalized additive model for location scale and shape/GAMLSS). In this research we unified them in the form of data analysis, including model using Computer Intensive Statistics (Bootstrap and Markov Chain Monte Carlo/ MCMC). All are readily accessible on our online Virtual Statistics Laboratory. The web (interface) make the statistical modeling becomes easier to apply and easier to compare them in order to find the most appropriate model for the data.

78 FR 75544 - Prestressed Concrete Steel Rail Tie Wire From Mexico: Preliminary Determination of Sales at Less...

Science.gov (United States)

2013-12-12

... DEPARTMENT OF COMMERCE International Trade Administration [A-201-843] Prestressed Concrete Steel...'') preliminarily determines that prestressed concrete steel rail tie wire (``PC tie wire'') from Mexico is being... element levels; suitable for use as prestressed tendons in concrete railroad ties (``PC tie wire''). High...

Application of Ontology Technology in Health Statistic Data Analysis.

Science.gov (United States)

Guo, Minjiang; Hu, Hongpu; Lei, Xingyun

2017-01-01

Research Purpose: establish health management ontology for analysis of health statistic data. Proposed Methods: this paper established health management ontology based on the analysis of the concepts in China Health Statistics Yearbook, and used protégé to define the syntactic and semantic structure of health statistical data. six classes of top-level ontology concepts and their subclasses had been extracted and the object properties and data properties were defined to establish the construction of these classes. By ontology instantiation, we can integrate multi-source heterogeneous data and enable administrators to have an overall understanding and analysis of the health statistic data. ontology technology provides a comprehensive and unified information integration structure of the health management domain and lays a foundation for the efficient analysis of multi-source and heterogeneous health system management data and enhancement of the management efficiency.

Liquid Crystal Bow-Tie Microstrip antenna for Wireless Communication Applications

Directory of Open Access Journals (Sweden)

B.T.P.Madhav

2014-06-01

Full Text Available In this paper we presented the design and analysis of Bow-Tie antenna on liquid crystal substrate, which is suitable for the Bluetooth/WLAN-2.4/WiBree/ZigBee applications. The Omni-directional radiation patterns along with moderate gain make the proposed antenna suitable for above mentioned applications. Details of the antenna design and simulated results Return loss, Input impedance, Radiation Patterns, E-Field, H-Field and Current Distributions, VSWR are presented and discussed. The proposed antenna is simulated at 2.4 GHz using Ansoft HFSS-11.

I.Kanta idejas un to ietekme uz mūsdienu tiesību attīstību

OpenAIRE

Smiltēna, Anda

2007-01-01

Darbs ir veltīts Imanuela Kanta tiesību filozofijas analīzei, uzmanību pievēršot tiesību teorijas jautājumiem, kā arī šo ideju praktiskajai ietekmei mūsdienu tiesību zinātnē. Pirmajā nodaļā aprakstītas galvenās Kanta tiesību filozofijas idejas, kas veido tiesību teorijas bāzi, nosaka tiesību sistēmu un to veidojošo elementu īpašības, nodala tiesības no morāles, iezīmē kategoriskā imperatīva un brīvības kategorijas nozīmi tiesībās. Otrā nodaļa veltīta neokantisma kustībai tiesībās un tās galve...

Explorations in Statistics: The Analysis of Change

Science.gov (United States)

Curran-Everett, Douglas; Williams, Calvin L.

2015-01-01

Learning about statistics is a lot like learning about science: the learning is more meaningful if you can actively explore. This tenth installment of "Explorations in Statistics" explores the analysis of a potential change in some physiological response. As researchers, we often express absolute change as percent change so we can…

Common pitfalls in statistical analysis: “P” values, statistical significance and confidence intervals

Science.gov (United States)

Ranganathan, Priya; Pramesh, C. S.; Buyse, Marc

2015-01-01

In the second part of a series on pitfalls in statistical analysis, we look at various ways in which a statistically significant study result can be expressed. We debunk some of the myths regarding the ‘P’ value, explain the importance of ‘confidence intervals’ and clarify the importance of including both values in a paper PMID:25878958

Tuning Features of Chinese Folk Song Singing: A Case Study of Hua'er Music.

Science.gov (United States)

Yang, Yang; Welch, Graham; Sundberg, Johan; Himonides, Evangelos

2015-07-01

The learning and teaching of different singing styles, such as operatic and Chinese folk singing, was often found to be very challenging in professional music education because of the complexity of varied musical properties and vocalizations. By studying the acoustical and musical parameters of the singing voice, this study identified distinctive tuning characteristics of a particular folk music in China-Hua'er music-to inform the ineffective folk singing practices, which were hampered by the neglect of inherent tuning issues in music. Thirteen unaccompanied folk song examples from four folk singers were digitally audio recorded in a sound studio. Using an analyzing toolkit consisting of Praat, PeakFit, and MS Excel, the fundamental frequencies (F0) of these song examples were extracted into sets of "anchor pitches" mostly used, which were further divided into 253 F0 clusters. The interval structures of anchor pitches within each song were analyzed and then compared across 13 examples providing parameters that indicate the tuning preference of this particular singing style. The data analyses demonstrated that all singers used a tuning pattern consisting of five major anchor pitches suggesting a nonequal-tempered bias in singing. This partly verified the pentatonic scale proposed in previous empirical research but also argued a potential misunderstanding of the studied folk music scale that failed to take intrinsic tuning issues into consideration. This study suggests that, in professional music training, any tuning strategy should be considered in terms of the reference pitch and likely tuning systems. Any accompanying instruments would need to be tuned to match the underlying tuning bias. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

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Rui Cao

2015-01-01

Full Text Available Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP, Caesalpinia sappan (CS, Evodia rutaecarpa (ER, Folium Artemisiae Argyi (FAA, Leonurus japonicus Houtt (LJH, Tumeric (Tu, Radix Paeoniae Alba (RPA, and Trogopterus Dung (TD effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv. (AS, Tabanus (Ta, and Pollen Typhae (PT, which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle

Ipsilateral deficits in 1-handed shoe tying after left or right hemisphere stroke.

Science.gov (United States)

Poole, Janet L; Sadek, Joseph; Haaland, Kathleen Y

2009-10-01

Poole JL, Sadek J, Haaland KY. Ipsilateral deficits in 1-handed shoe tying after left or right hemisphere stroke. To examine 1-handed shoe tying performance and whether cognitive deficits more associated with left or right hemisphere damage differentially affect it after unilateral stroke. Observational cohort comparing ipsilesional shoe tying, spatial and language skills, and limb praxis. Primary care Veterans Affairs and private medical center. Not applicable. Volunteer right-handed sample of adults with left or right hemisphere damage and healthy demographically matched adults. The number of correct trials and the total time to complete 10 trials tying a shoe using the 1-handed method. Both stroke groups had fewer correct trials and were significantly slower tying the shoe than the control group. Spatial skills predicted accuracy and speed after right hemisphere damage. After left hemisphere damage, accuracy was predicted by spatial skills and limb praxis, while speed was predicted by limb praxis only. Ipsilesional shoe tying is similarly impaired after left or right hemisphere damage, but for different reasons. Spatial deficits had a greater influence after right hemisphere damage, and limb apraxia had a greater influence after left hemisphere damage. Language deficits did not affect performance, indicating that aphasia does not preclude using this therapy approach. These results suggest that rehabilitation professionals should consider assessment of limb apraxia and ipsilesional skill training in the performance of everyday tasks.

78 FR 29325 - Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and...

Science.gov (United States)

2013-05-20

...] Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and Thailand: Initiation... of prestressed concrete steel rail tie wire (``PC tie wire'') from Mexico, the PRC, and Thailand... Prestressed Concrete Steel Rail Tie Wire from the PRC, Mexico, and Thailand, filed on April 23, 2013 (the...

Footprint Contact Area and Interface Pressure Comparison Between the Knotless and Knot-Tying Transosseous-Equivalent Technique for Rotator Cuff Repair.

Science.gov (United States)

Kim, Sung-Jae; Kim, Sung-Hwan; Moon, Hyun-Soo; Chun, Yong-Min

2016-01-01

To quantify and compare the footprint contact area and interface pressure on the greater tuberosity between knotless and knot-tying transosseous-equivalent (TOE) repair using pressure-sensitive film. We used 11 pairs of fresh-frozen cadaveric shoulders (22 specimens), in which rotator cuff tears were created before repair. Each pair was randomized to either conventional medial knot-tying TOE repair (group A) or medial knotless TOE repair using the modified Mason-Allen technique (group B). Pressure-sensitive film was used to quantify the pressurized contact area and interface pressure between the greater tuberosity and supraspinatus tendon. The mean pressurized contact area was 33.2 ± 2.5 mm(2) for group A and 28.4 ± 2.4 mm(2) for group B. There was a significant difference between groups (P = .005). Although the overall contact configuration of both groups was similar and showed an M shape, group A showed a greater pressurized configuration around the medial row. The mean interface pressure was 0.20 ± 0.02 MPa for group A and 0.17 ± 0.02 MPa for group B. There was a significant difference between groups (P = .001). Contrary to our hypothesis, in this time-zero study, medial knotless TOE repair using a modified Mason-Allen suture produced a significantly inferior footprint contact area and interface pressure compared with conventional medial knot-tying TOE repair. Even though we found a statistically significant difference between the 2 repair methods, it is still unknown if this statistical difference seen in our study has any clinical and radiologic significance. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Construction loads experienced by plastic composite ties.

Science.gov (United States)

2014-07-01

Damage to plastic composite ties during handling and track installation has been reported by a number of railroads. Results from : a survey conducted to identify specific handling issues were used to develop field and laboratory tests to measure the ...

Single-Phase LLCL-Filter-based Grid-Tied Inverter with Low-Pass Filter Based Capacitor Current Feedback Active damper

DEFF Research Database (Denmark)

Liu, Yuan; Wu, Weimin; Li, Yun

2016-01-01

The capacitor-current-feedback active damping method is attractive for high-order-filter-based high power grid-tied inverter when the grid impedance varies within a wide range. In order to improve the system control bandwidth and attenuate the high order grid background harmonics by using the quasi....... In this paper, a low pass filter is proposed to be inserted in the capacitor current feedback loop op LLCL-filter based grid-tied inverter together with a digital proportional and differential compensator. The detailed theoretical analysis is given. For verification, simulations on a 2kW/220V/10kHz LLCL...

TECHNIQUE OF THE STATISTICAL ANALYSIS OF INVESTMENT APPEAL OF THE REGION

Directory of Open Access Journals (Sweden)

А. А. Vershinina

2014-01-01

Full Text Available The technique of the statistical analysis of investment appeal of the region is given in scientific article for direct foreign investments. Definition of a technique of the statistical analysis is given, analysis stages reveal, the mathematico-statistical tools are considered.

Social ties and risk for cancer - a prospective cohort study

DEFF Research Database (Denmark)

Bergelt, Corinna; Prescott, Eva; Grønbaek, Morten

2009-01-01

consisted of 8 548 Danes who had been examined in 1991-1994 within the Copenhagen City Heart Study. The median length of follow-up was 9.3 years (range, 0-11.2 years). Social ties were measured from answers to a questionnaire on social networks. Regression analyses for cancers at the most frequent sites......BACKGROUND: Poor social support and small social networks have been associated with increased risks for conditions such as coronary heart disease as well as with overall mortality. We investigated the association between social ties and risk for cancer. MATERIAL AND METHODS: The study sample...... (breast, lung, prostate and colon and rectum) were conducted with the Cox proportional hazards model, with adjustment for a number of well-known risk factors for cancer. RESULTS: While we found no significant association between social ties and risk for cancer in men, women with high social network scores...

Social ties and risk for cancer - a prospective cohort study

DEFF Research Database (Denmark)

Bergelt, C.; Prescott, E.; Gronbaek, M.

2009-01-01

consisted of 8 548 Danes who had been examined in 1991-1994 within the Copenhagen City Heart Study. The median length of follow-up was 9.3 years (range, 0-11.2 years). Social ties were measured from answers to a questionnaire on social networks. Regression analyses for cancers at the most frequent sites......Background. Poor social support and small social networks have been associated with increased risks for conditions such as coronary heart disease as well as with overall mortality. We investigated the association between social ties and risk for cancer. Material and methods. The study sample...... (breast, lung, prostate and colon and rectum) were conducted with the Cox proportional hazards model, with adjustment for a number of well-known risk factors for cancer. Results. While we found no significant association between social ties and risk for cancer in men, women with high social network scores...

Statistical analysis of network data with R

CERN Document Server

Kolaczyk, Eric D

2014-01-01

Networks have permeated everyday life through everyday realities like the Internet, social networks, and viral marketing. As such, network analysis is an important growth area in the quantitative sciences, with roots in social network analysis going back to the 1930s and graph theory going back centuries. Measurement and analysis are integral components of network research. As a result, statistical methods play a critical role in network analysis. This book is the first of its kind in network research. It can be used as a stand-alone resource in which multiple R packages are used to illustrate how to conduct a wide range of network analyses, from basic manipulation and visualization, to summary and characterization, to modeling of network data. The central package is igraph, which provides extensive capabilities for studying network graphs in R. This text builds on Eric D. Kolaczyk’s book Statistical Analysis of Network Data (Springer, 2009).

[Construction of recombinant lentiviral vector of Tie2-RNAi and its influence on malignant melanoma cells in vitro].

Science.gov (United States)

Shan, Xiu-ying; Liu, Zhao-liang; Wang, Biao; Guo, Guo-xiang; Wang, Mei-shui; Zhuang, Fu-lian; Cai, Chuan-shu; Zhang, Ming-feng; Zhang, Yan-ding

2011-07-01

To construct lentivector carrying Tie2-Small interfering RNA (SiRNA), so as to study its influence on malignant melanoma cells. Recombinant plasmid pSilencer 1.0-U6-Tie2-siRNA and plasmid pNL-EGFP were digested with XbaI, ligated a target lentiviral transfer plasmid of pNL-EGFP-U6-Tie2-I or pNL-EGFP-U6-Tie2-II, and then the electrophoresis clones was sequenced. Plasmids of pNL-EGFP-U6-Tie2-I and pNL-EGFP-U6-Tie2-II were constructed and combined with pVSVG and pHelper, respectively, to constitute lentiviral vector system of three plasmids. The Lentiviral vector system was transfected into 293T cell to produce pNL-EGFP-U6-Tie2- I and pNL-EGFP-U6-Tie2-II lentivirus. Then the supernatant was collected to determine the titer. Malignant melanoma cells were infected by both lentiviruses and identified by Realtime RT-PCR to assess inhibitory efficiency. The recombinant lentiviral vectors of Tie2-RNAi were constructed successfully which were analyzed with restriction enzyme digestion and identified by sequencing. And the titer of lentiviral vector was 8.8 x 10(3)/ml, which was determined by 293T cell. The results of Realtime RT-PCR demonstrated that the lentiviral vectors of Tie2-RNAi could infect malignant melanoma cells and inhibit the expression of Tie2 genes in malignant melanoma cells (P0.05) between the two lentiviral vectors of Tie2-RNAi. Lentivector carrying Tie2-SiRNA can be constructed successfully and inhibit the expression of Tie2 gene in vitro significantly. The study will supply the theory basis for the further research on the inhibition of tumor growth in vivo.

LLCL-Filter Based Single-Phase Grid-Tied Aalborg Inverter

DEFF Research Database (Denmark)

Wu, Weimin; Feng, Shuangshuang; Ji, Junhao

2014-01-01

The Aalborg Inverter is a new type of high efficient DC/AC grid-tied inverter, where the input DC voltage can vary in a wide range. Compared with the LCL-filter, the LLCL-filter can save the total inductance for the conventional voltage source inverter. In this paper, an LLCL-filter based Aalborg...... Inverter is proposed and its character is illustrated through the small signal analysis in both “Buck” and “Buck-Boost” mode. From the modeling, it can be seen that the resonant inductor in the capacitor loop has not brought extra control difficulties, whereas more inductance in the power loop can be saved...

The emotional responses of browsing Facebook: Happiness, envy, and the role of tie strength.

Science.gov (United States)

Lin, Ruoyun; Utz, Sonja

2015-11-01

On Facebook, users are exposed to posts from both strong and weak ties. Even though several studies have examined the emotional consequences of using Facebook, less attention has been paid to the role of tie strength. This paper aims to explore the emotional outcomes of reading a post on Facebook and examine the role of tie strength in predicting happiness and envy. Two studies - one correlational, based on a sample of 207 American participants and the other experimental, based on a sample of 194 German participants - were conducted in 2014. In Study 2, envy was further distinguished into benign and malicious envy. Based on a multi-method approach, the results showed that positive emotions are more prevalent than negative emotions while browsing Facebook. Moreover, tie strength is positively associated with the feeling of happiness and benign envy, whereas malicious envy is independent of tie strength after reading a (positive) post on Facebook.

Semiclassical analysis, Witten Laplacians, and statistical mechanis

CERN Document Server

Helffer, Bernard

2002-01-01

This important book explains how the technique of Witten Laplacians may be useful in statistical mechanics. It considers the problem of analyzing the decay of correlations, after presenting its origin in statistical mechanics. In addition, it compares the Witten Laplacian approach with other techniques, such as the transfer matrix approach and its semiclassical analysis. The author concludes by providing a complete proof of the uniform Log-Sobolev inequality. Contents: Witten Laplacians Approach; Problems in Statistical Mechanics with Discrete Spins; Laplace Integrals and Transfer Operators; S

A novel statistic for genome-wide interaction analysis.

Directory of Open Access Journals (Sweden)

Xuesen Wu

2010-09-01

Full Text Available Although great progress in genome-wide association studies (GWAS has been made, the significant SNP associations identified by GWAS account for only a few percent of the genetic variance, leading many to question where and how we can find the missing heritability. There is increasing interest in genome-wide interaction analysis as a possible source of finding heritability unexplained by current GWAS. However, the existing statistics for testing interaction have low power for genome-wide interaction analysis. To meet challenges raised by genome-wide interactional analysis, we have developed a novel statistic for testing interaction between two loci (either linked or unlinked. The null distribution and the type I error rates of the new statistic for testing interaction are validated using simulations. Extensive power studies show that the developed statistic has much higher power to detect interaction than classical logistic regression. The results identified 44 and 211 pairs of SNPs showing significant evidence of interactions with FDR<0.001 and 0.001analysis is a valuable tool for finding remaining missing heritability unexplained by the current GWAS, and the developed novel statistic is able to search significant interaction between SNPs across the genome. Real data analysis showed that the results of genome-wide interaction analysis can be replicated in two independent studies.

Reducing Electromagnetic Interference in a Grid Tied Single Phase Power Inverter

Science.gov (United States)

2016-09-01

With the growing demand for a reliable electrical grid, backup power supplies and energy management systems are a necessity. Systems such as server...ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER INVERTER by Jason Hassan Valiani September 2016 Thesis Advisor: Giovanna Oriti...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE REDUCING ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER

A composite passive damping method of the LLCL-filter based grid-tied inverter

DEFF Research Database (Denmark)

Wu, Weimin; Huang, Min; Sun, Yunjie

2012-01-01

This paper investigates the maximum and the minimum gain of the proportional resonant based grid current controller for a grid-tied inverter with a passive damped high-order power filter. It is found that the choice of the controller gain is limited to the local maximum amplitude determined by Q......-factor around the characteristic frequency of the filter and grid impedance. To obtain the Q-factor of a high-order system, an equivalent circuit analysis method is proposed and illustrated through several classical passive damped LCL- and LLCL-filters. It is shown that both the RC parallel damper...... that is in parallel with the capacitor of the LCL-filter or with the Lf-Cf resonant circuit of the LLCL-filter, and the RL series damper in series with the grid-side inductor have their own application limits. Thus, a composite passive damped LLCL-filter for the grid-tied inverter is proposed, which can effectively...

Strengthening Social Ties to Increase Confidence and Self-Esteem Among Sexual and Gender Minority Youth.

Science.gov (United States)

Romijnders, Kim A; Wilkerson, J Michael; Crutzen, Rik; Kok, Gerjo; Bauldry, Jessica; Lawler, Sylvia M

2017-05-01

Sexual and gender minority (SGM) youth too often live in nonsupportive environments. This study reports the influence of social support from primary and secondary social ties on confidence and self-esteem among participants in Hatch Youth, a drop-in group-level intervention for SGM youth. Each 3-hour Hatch Youth meeting consists of a social, educational, and youth-led support hour. Over 14 weeks, these meetings were randomly observed and individual interviews with participating youth ( n = 12) and staff and volunteers ( n = 12) were conducted; data underwent a content analysis. Participants perceived an increase in confidence and self-esteem through enhanced bonding with family and friends, a sense of belonging, and community empowerment because of their involvement with Hatch Youth, suggesting drop-in centers can strengthen secondary social ties and improve confidence and self-esteem.

A statistical approach to plasma profile analysis

International Nuclear Information System (INIS)

Kardaun, O.J.W.F.; McCarthy, P.J.; Lackner, K.; Riedel, K.S.

1990-05-01

A general statistical approach to the parameterisation and analysis of tokamak profiles is presented. The modelling of the profile dependence on both the radius and the plasma parameters is discussed, and pertinent, classical as well as robust, methods of estimation are reviewed. Special attention is given to statistical tests for discriminating between the various models, and to the construction of confidence intervals for the parameterised profiles and the associated global quantities. The statistical approach is shown to provide a rigorous approach to the empirical testing of plasma profile invariance. (orig.)

A community of strangers: the dis-embedding of social ties.

Science.gov (United States)

Parigi, Paolo; State, Bogdan; Dakhlallah, Diana; Corten, Rense; Cook, Karen

2013-01-01

In this paper we explore two contrasting perspectives on individuals' participation in associations. On the one hand, some have considered participation the byproduct of pre-existing friendship ties--the more friends one already has in the association, the more likely he or she is to participate. On the other hand, some have considered participation to be driven by the association's capacity to form new identities--the more new friends one meets in the association, the more likely he or she is to participate. We use detailed temporal data from an online association to adjudicate between these two mechanisms and explore their interplay. Our results show a significant impact of new friendship ties on participation, compared to a negligible impact of pre-existing friends, defined here as ties to other members formed outside of the organization's context. We relate this finding to the sociological literature on participation and we explore its implications in the discussion.

A community of strangers: the dis-embedding of social ties.

Directory of Open Access Journals (Sweden)

Paolo Parigi

Full Text Available In this paper we explore two contrasting perspectives on individuals' participation in associations. On the one hand, some have considered participation the byproduct of pre-existing friendship ties--the more friends one already has in the association, the more likely he or she is to participate. On the other hand, some have considered participation to be driven by the association's capacity to form new identities--the more new friends one meets in the association, the more likely he or she is to participate. We use detailed temporal data from an online association to adjudicate between these two mechanisms and explore their interplay. Our results show a significant impact of new friendship ties on participation, compared to a negligible impact of pre-existing friends, defined here as ties to other members formed outside of the organization's context. We relate this finding to the sociological literature on participation and we explore its implications in the discussion.

Improvement and Application of the Softened Strut-and-Tie Model

Science.gov (United States)

Fan, Guoxi; Wang, Debin; Diao, Yuhong; Shang, Huaishuai; Tang, Xiaocheng; Sun, Hai

2017-11-01

Previous experimental researches indicate that reinforced concrete beam-column joints play an important role in the mechanical properties of moment resisting frame structures, so as to require proper design. The aims of this paper are to predict the joint carrying capacity and cracks development theoretically. Thus, a rational model needs to be developed. Based on the former considerations, the softened strut-and-tie model is selected to be introduced and analyzed. Four adjustments including modifications of the depth of the diagonal strut, the inclination angle of diagonal compression strut, the smeared stress of mild steel bars embedded in concrete, as well as the softening coefficient are made. After that, the carrying capacity of beam-column joint and cracks development are predicted using the improved softened strut-and-tie model. Based on the test results, it is not difficult to find that the improved softened strut-and-tie model can be used to predict the joint carrying capacity and cracks development with sufficient accuracy.

Study designs, use of statistical tests, and statistical analysis software choice in 2015: Results from two Pakistani monthly Medline indexed journals.

Science.gov (United States)

Shaikh, Masood Ali

2017-09-01

Assessment of research articles in terms of study designs used, statistical tests applied and the use of statistical analysis programmes help determine research activity profile and trends in the country. In this descriptive study, all original articles published by Journal of Pakistan Medical Association (JPMA) and Journal of the College of Physicians and Surgeons Pakistan (JCPSP), in the year 2015 were reviewed in terms of study designs used, application of statistical tests, and the use of statistical analysis programmes. JPMA and JCPSP published 192 and 128 original articles, respectively, in the year 2015. Results of this study indicate that cross-sectional study design, bivariate inferential statistical analysis entailing comparison between two variables/groups, and use of statistical software programme SPSS to be the most common study design, inferential statistical analysis, and statistical analysis software programmes, respectively. These results echo previously published assessment of these two journals for the year 2014.

Statistical analysis of brake squeal noise

Science.gov (United States)

Oberst, S.; Lai, J. C. S.

2011-06-01

Despite substantial research efforts applied to the prediction of brake squeal noise since the early 20th century, the mechanisms behind its generation are still not fully understood. Squealing brakes are of significant concern to the automobile industry, mainly because of the costs associated with warranty claims. In order to remedy the problems inherent in designing quieter brakes and, therefore, to understand the mechanisms, a design of experiments study, using a noise dynamometer, was performed by a brake system manufacturer to determine the influence of geometrical parameters (namely, the number and location of slots) of brake pads on brake squeal noise. The experimental results were evaluated with a noise index and ranked for warm and cold brake stops. These data are analysed here using statistical descriptors based on population distributions, and a correlation analysis, to gain greater insight into the functional dependency between the time-averaged friction coefficient as the input and the peak sound pressure level data as the output quantity. The correlation analysis between the time-averaged friction coefficient and peak sound pressure data is performed by applying a semblance analysis and a joint recurrence quantification analysis. Linear measures are compared with complexity measures (nonlinear) based on statistics from the underlying joint recurrence plots. Results show that linear measures cannot be used to rank the noise performance of the four test pad configurations. On the other hand, the ranking of the noise performance of the test pad configurations based on the noise index agrees with that based on nonlinear measures: the higher the nonlinearity between the time-averaged friction coefficient and peak sound pressure, the worse the squeal. These results highlight the nonlinear character of brake squeal and indicate the potential of using nonlinear statistical analysis tools to analyse disc brake squeal.

The Statistical Analysis of Time Series

CERN Document Server

Anderson, T W

2011-01-01

The Wiley Classics Library consists of selected books that have become recognized classics in their respective fields. With these new unabridged and inexpensive editions, Wiley hopes to extend the life of these important works by making them available to future generations of mathematicians and scientists. Currently available in the Series: T. W. Anderson Statistical Analysis of Time Series T. S. Arthanari & Yadolah Dodge Mathematical Programming in Statistics Emil Artin Geometric Algebra Norman T. J. Bailey The Elements of Stochastic Processes with Applications to the Natural Sciences George

Analysis of room transfer function and reverberant signal statistics

DEFF Research Database (Denmark)

Georganti, Eleftheria; Mourjopoulos, John; Jacobsen, Finn

2008-01-01

For some time now, statistical analysis has been a valuable tool in analyzing room transfer functions (RTFs). This work examines existing statistical time-frequency models and techniques for RTF analysis (e.g., Schroeder's stochastic model and the standard deviation over frequency bands for the RTF...... magnitude and phase). RTF fractional octave smoothing, as with 1-slash 3 octave analysis, may lead to RTF simplifications that can be useful for several audio applications, like room compensation, room modeling, auralisation purposes. The aim of this work is to identify the relationship of optimal response...... and the corresponding ratio of the direct and reverberant signal. In addition, this work examines the statistical quantities for speech and audio signals prior to their reproduction within rooms and when recorded in rooms. Histograms and other statistical distributions are used to compare RTF minima of typical...

Surface-enhanced Raman scattering study of the healing of radial fractures treated with or without Huo-Xue-Hua-Yu decoction therapy

Science.gov (United States)

Chen, Weiwei; Huang, Hao; Chen, Rong; Feng, Shangyuan; Yu, Yun; Lin, Duo; Lin, Jia

2014-11-01

This study aimed to assess, through surface-enhanced Raman scattering (SERS) spectroscopy, the incorporation of calcium hydroxyapatite (CHA ~960 cm-1) and other biochemical substances in the repair of complete radial fractures in rabbits treated with or without Huo-Xue-Hua-Yu decoction (HXHYD) therapy. A total of 18 rabbits with complete radial fractures were randomly divided into two groups; one group was treated with HXHYD therapy and the other without therapy acted as a control. The animals were sacrificed at 15, 30 and 45 d after surgery. Specimens were routinely prepared for SERS measurement and high quality SERS spectra from a mixture of bone tissues and silver nanoparticles were obtained. The mineral-to-matrix ratios from the control and treated groups were calculated. Results showed that both deposition content of CHA measured by SERS spectroscopy and the mineral-to-matrix ratio in the treated group were always greater than those of the control group during the experiment, demonstrating that HXHYD therapy is effective in improving fracture healing and that SERS spectroscopy might be a novel tool to assess fracture healing.

Relationships: The Critical Ties That Bind Professionals.

Science.gov (United States)

Roper, Larry

2002-01-01

This article proposes that the success of student affairs professionals is more closely tied to their ability to construct and manage essential relationships during their careers than any other activity. The author discusses essential principles and skills in developing and managing professional relationships. (GCP)

Maintaining work-related personal ties following retirement

NARCIS (Netherlands)

Cozijnsen, M.R.; Stevens, N.L.; van Tilburg, T.G.

2010-01-01

This study examines the consequences of retirement for the continuation of work-related personal ties. The hypothesis is that their inclusion in personal networks after retirement has become more likely because these relationships have become less role based in today's social-cultural context. Data

Social position, social ties and adult's oral health: 13 year cohort study.

Science.gov (United States)

Vettore, Mario Vianna; Faerstein, Eduardo; Baker, Sarah Ruth

2016-01-01

This study explored different pathways by which social position and social ties influence adult's oral health over a 13-year period. A cohort investigation (Pro-Saúde Study) was conducted of non-faculty civil servants at a university in Rio de Janeiro, Brazil (N=1613). Baseline data collected in 1999 included age, social position, social ties, and access to dental care. Psychological factors and smoking were assessed in 2001, whereas tooth loss and self-rated oral health (SROH) were collected in 2012. A hypothesised model exploring different direct and indirect pathways was developed and tested using structural equation modelling. The model was a good fit to the data and accounted for 40% and 27% of the variance in tooth loss and SROH, respectively. A greater social position was linked to more social ties (β=0.31), health insurance (β=0.48), low psychological distress (β=0.07), less smoking (β=-0.21), more regular dental visiting (β=0.30), less tooth loss (β=-0.44) and better SROH (β=-0.25) over time. Social position (β=0.0005) and social ties (β=-0.0015) were linked indirectly with psychological distress, smoking and tooth loss. Social position was linked indirectly with social ties, psychological distress and SROH (β=-0.0071). Poor social position and weak social ties were important predictors for tooth loss and poor SROH in adults over the 13-year period. Direct and indirect pathways via psychological factors and smoking on the aforementioned relationships were identified, suggesting different areas of intervention to promote adults' oral health. Adult's oral health is influenced by social conditions through direct and indirect pathways, including via psychological factors and smoking. Copyright © 2015. Published by Elsevier Ltd.

Social Identity, Social Ties and Social Capital: A Study in Gaming Context

Science.gov (United States)

Jiang, Hao

2012-01-01

This work will focus on how different social relationships, namely shared identity and personal tie, will impact cooperative behavior, a form of social capital. I designed and conducted an economic game study to show that shared identity and personal ties work differently on cooperation among people and resource flow in social groups. Many factors…

Transit safety & security statistics & analysis 2002 annual report (formerly SAMIS)

Science.gov (United States)

2004-12-01

The Transit Safety & Security Statistics & Analysis 2002 Annual Report (formerly SAMIS) is a compilation and analysis of mass transit accident, casualty, and crime statistics reported under the Federal Transit Administrations (FTAs) National Tr...

Transit safety & security statistics & analysis 2003 annual report (formerly SAMIS)

Science.gov (United States)

2005-12-01

The Transit Safety & Security Statistics & Analysis 2003 Annual Report (formerly SAMIS) is a compilation and analysis of mass transit accident, casualty, and crime statistics reported under the Federal Transit Administrations (FTAs) National Tr...

ERT and Well Data Tie for Nickel Laterite Characterization

Science.gov (United States)

Aswad, Sabrianto; Mamela Mais, Difar; Syamsuddin; Wanni

2018-03-01

The need of ERT method in nickel latentes exploration can’t be deny. This method have capability to make exploration more effective and efficient. In reality this method still remain ambiguity in its application, especially for geologist and mining expert. These ambiguity related with layer zone determination (limonite, saprolite and bedrock), the same resistivity values in the different zones and determination of bedrock. This paper try to expose interesting fact to overcome this ambiguity by using ERT data and drill data tie. This tie will show characteristic of nickel lateric based on resisitivity value and the contribution of chemistry element for resistivity value. Data ERT was collected by using gradient configuration and well data consist of mayor element and minor element. Tie result showed difference resistivity value in limonite layer influence by Fe, H2O and Ni, where resistivity value from saprolite layer influenced by Fe, H2O, Si02, MgO, Al, Cr, and Ni in certain accumulation. In bedrock layer, almost all drill data did not reach bedrock but only reached the boulder alone, it is supported by the value of the resistivity of rock unserpentinized peridotite which should show a relatively large resistivity value

77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties

Science.gov (United States)

2012-04-10

... the Buy America Waiver Request for Vossloh 101-LV Concrete Ties AGENCY: Federal Railroad... concrete ties, which contain certain components not manufactured in the United States. In furtherance of... concrete ties. FRA has received this request from the four States for the following projects: (a) The...

A 10-Year Follow-Up Study of Social Ties and Functional Health among the Old: The AGES Project.

Science.gov (United States)

Murata, Chiyoe; Saito, Tami; Tsuji, Taishi; Saito, Masashige; Kondo, Katsunori

2017-07-03

In Asian nations, family ties are considered important. However, it is not clear what happens among older people with no such ties. To investigate the association, we used longitudinal data from the Aichi Gerontological Evaluation Study (AGES) project. Functionally independent older people at baseline ( N = 14,088) in 10 municipalities were followed from 2003 to 2013. Social ties were assessed by asking about their social support exchange with family, relatives, friends, or neighbors. Cox proportional hazard models were employed to investigate the association between social ties and the onset of functional disability adjusting for age, health status, and living arrangement. We found that social ties with co-residing family members, and those with friends or neighbors, independently protected functional health with hazard ratios of 0.81 and 0.85 among men. Among women, ties with friend or neighbors had a stronger effect on health compared to their male counterparts with a hazard ratio of 0.89. The fact that social ties with friends or neighbors are associated with a lower risk of functional decline, independent of family support, serves to underscore the importance of promoting social ties, especially among those lacking family ties.

Relational benefits and quality of relation – towards understanding of the ties between science and business

Directory of Open Access Journals (Sweden)

Małgorzata Grzegorczyk

2016-06-01

Full Text Available The goal of this article is to answer the question in what way relational marketing and in particular, the concept of relational benefits, as well as quality of relation may influence the transfer of knowledge and technologies from universities to business. Another goal is to highlight significant, future directions of research in this area. Integration of the theory of relational marketing and technology transfer may create a new framework for fuller understanding of the ties between science and business. Research in this area may contribute to the expansion and development of the theory of relational marketing, which until now was limited to the analysis of relations within a single sector. The results of conducted research show that ties characterized by high relational engagement are common, recognized by both academic and business environment as precious and play an important role in stimulating innovations. The quality of relations and relational benefits may play an important role in building long-term ties between universities and the industry. Integration of behavioural theories with the theory of technology transfer may contribute to a better understanding of the behaviour of particular participants of the transfer on the individual level.

The emergence of the ecological mind in Hua-Yen/Kegon Buddhism and Jungian psychology.

Science.gov (United States)

Cambray, Joe

2017-02-01

The complexity associated with deep interconnectedness in nature is beginning to be articulated and elaborated in the field of ecological studies. While some parallels to the psyche have been made and the field of Eco-psychology has been developing, Jung's explicit contribution by way of the image of rhizomes has not been considered in detail. Philosopher Gilles Deleuze acknowledges borrowing the term from Jung, though he disagreed with Jung's Empedoclean use of the term. The paper presents some fundamental properties of rhizomes along with contemporary scientific research on mycorrhizal (fungal) networks. Comparisons are made, first with classical symbolic forms, demonstrating some overlap but also some differences. Then comparison of rhizomal networks is made to those found both in mammalian brains and in recent images of the 'cosmic web'. While no hard conclusions can be drawn from these images, their remarkable similarities are suggestive of a need to reconsider what is meant by 'intelligence'. The cosmic web is one of the largest structures in the known universe (clusters of galaxies which form into filaments and walls) with empty spaces in between. Exploration of the structure of this web leads to a discussion of dark matter and dark energy, current hot topics in science, probing into the mysteries of our 'Big-Bang' cosmology. An additional comparison of the emerging image of the universe as a whole with the ancient Chinese Buddhist cosmological vision from the Hua-Yen School (Kegon in Japan) again reveals profound parallels. The potential convergence of aspects of subjective, or meditative, explorations with objective scientific constructions is striking and offers links between East and West, as well as potential confirmation of the objective aspects of empathy. © 2017, The Society of Analytical Psychology.

Statistical Modelling of Wind Proles - Data Analysis and Modelling

DEFF Research Database (Denmark)

Jónsson, Tryggvi; Pinson, Pierre

The aim of the analysis presented in this document is to investigate whether statistical models can be used to make very short-term predictions of wind profiles.......The aim of the analysis presented in this document is to investigate whether statistical models can be used to make very short-term predictions of wind profiles....

Neural correlates of dynamically evolving interpersonal ties predict prosocial behaviour

Directory of Open Access Journals (Sweden)

Johannes Jacobus Fahrenfort

2012-03-01

Full Text Available There is a growing interest for the determinants of human choice behaviour in social settings. Upon initial contact, investment choices in social settings can be inherently risky, as the degree to which the other person will reciprocate is unknown. Nevertheless, people have been shown to exhibit prosocial behaviour even in one-shot laboratory settings where all interaction has been taken away. A logical step has been to link such behaviour to trait empathy-related neurobiological networks. However, as a social interaction unfolds, the degree of uncertainty with respect to the expected payoff of choice behaviour may change as a function of the interaction. Here we attempt to capture this factor. We show that the interpersonal tie one develops with another person during interaction - rather than trait empathy - motivates investment in a public good that is shared with an anonymous interaction partner. We examined how individual differences in trait empathy and interpersonal ties modulate neural responses to imposed monetary sharing. After, but not before interaction in a public good game, sharing prompted activation of neural systems associated with reward (striatum, empathy (anterior insular cortex [AIC] and anterior cingulate cortex [ACC] as well as altruism and social significance (posterior superior temporal sulcus [pSTS]. Although these activations could be linked to both empathy and interpersonal ties, only tie-related pSTS activation predicted prosocial behaviour during subsequent interaction, suggesting a neural substrate for keeping track of social relevance.

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb.

Science.gov (United States)

Patel, Ashish S; Smith, Alberto; Nucera, Silvia; Biziato, Daniela; Saha, Prakash; Attia, Rizwan Q; Humphries, Julia; Mattock, Katherine; Grover, Steven P; Lyons, Oliver T; Guidotti, Luca G; Siow, Richard; Ivetic, Aleksandar; Egginton, Stuart; Waltham, Matthew; Naldini, Luigi; De Palma, Michele; Modarai, Bijan

2013-06-01

A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophages (TEMs) are a myeloid cell subset known to be highly angiogenic in tumours. This study aimed to examine the kinetics of TEMs in patients with CLI and whether these cells promote neovascularization of the ischemic limb. Here we show that there are 10-fold more circulating TEMs in CLI patients, and removal of ischemia reduces their numbers to normal levels. TEM numbers in ischemic muscle are two-fold greater than normoxic muscle from the same patient. TEMs from patients with CLI display greater proangiogenic activity than TIE2-negative monocytes in vitro. Using a mouse model of hindlimb ischemia, lentiviral-based Tie2 knockdown in TEMs impaired recovery from ischemia, whereas delivery of mouse macrophages overexpressing TIE2, or human TEMs isolated from CLI patients, rescued limb ischemia. These data suggest that enhancing TEM recruitment to the ischemic muscle may have the potential to improve limb neovascularization in CLI patients. Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO.

Commercial lumber, round timbers, and ties

Science.gov (United States)

David E. Kretschmann

2010-01-01

When sawn, a log yields round timber, ties, or lumber of varying quality. This chapter presents a general discussion of grading, standards, and specifications for these commercial products. In a broad sense, commercial lumber is any lumber that is bought or sold in the normal channels of commerce. Commercial lumber may be found in a variety of forms, species, and types...

Statistical analysis of long term spatial and temporal trends of ...

Indian Academy of Sciences (India)

Statistical analysis of long term spatial and temporal trends of temperature ... CGCM3; HadCM3; modified Mann–Kendall test; statistical analysis; Sutlej basin. ... Water Resources Systems Division, National Institute of Hydrology, Roorkee 247 ...

CORSSA: The Community Online Resource for Statistical Seismicity Analysis

Science.gov (United States)

Michael, Andrew J.; Wiemer, Stefan

2010-01-01

Statistical seismology is the application of rigorous statistical methods to earthquake science with the goal of improving our knowledge of how the earth works. Within statistical seismology there is a strong emphasis on the analysis of seismicity data in order to improve our scientific understanding of earthquakes and to improve the evaluation and testing of earthquake forecasts, earthquake early warning, and seismic hazards assessments. Given the societal importance of these applications, statistical seismology must be done well. Unfortunately, a lack of educational resources and available software tools make it difficult for students and new practitioners to learn about this discipline. The goal of the Community Online Resource for Statistical Seismicity Analysis (CORSSA) is to promote excellence in statistical seismology by providing the knowledge and resources necessary to understand and implement the best practices, so that the reader can apply these methods to their own research. This introduction describes the motivation for and vision of CORRSA. It also describes its structure and contents.

Platelet-rich plasma extract prevents pulmonary edema through angiopoietin-Tie2 signaling.

Science.gov (United States)

Mammoto, Tadanori; Jiang, Amanda; Jiang, Elisabeth; Mammoto, Akiko

2015-01-01

Increased vascular permeability contributes to life-threatening pathological conditions, such as acute respiratory distress syndrome. Current treatments for sepsis-induced pulmonary edema rely on low-tidal volume mechanical ventilation, fluid management, and pharmacological use of a single angiogenic or chemical factor with antipermeability activity. However, it is becoming clear that a combination of multiple angiogenic/chemical factors rather than a single factor is required for maintaining stable and functional blood vessels. We have demonstrated that mouse platelet-rich plasma (PRP) extract contains abundant angiopoietin (Ang) 1 and multiple other factors (e.g., platelet-derived growth factor), which potentially stabilize vascular integrity. Here, we show that PRP extract increases tyrosine phosphorylation levels of Tunica internal endothelial cell kinase (Tie2) and attenuates disruption of cell-cell junctional integrity induced by inflammatory cytokine in cultured human microvascular endothelial cells. Systemic injection of PRP extract also increases Tie2 phosphorylation in mouse lung and prevents endotoxin-induced pulmonary edema and the consequent decreases in lung compliance and exercise intolerance resulting from endotoxin challenge. Soluble Tie2 receptor, which inhibits Ang-Tie2 signaling, suppresses the ability of PRP extract to inhibit pulmonary edema in mouse lung. These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang-Tie2 signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema and various lung diseases caused by abnormal vascular permeability.

Multivariate statistical analysis a high-dimensional approach

CERN Document Server

Serdobolskii, V

2000-01-01

In the last few decades the accumulation of large amounts of in­ formation in numerous applications. has stimtllated an increased in­ terest in multivariate analysis. Computer technologies allow one to use multi-dimensional and multi-parametric models successfully. At the same time, an interest arose in statistical analysis with a de­ ficiency of sample data. Nevertheless, it is difficult to describe the recent state of affairs in applied multivariate methods as satisfactory. Unimprovable (dominating) statistical procedures are still unknown except for a few specific cases. The simplest problem of estimat­ ing the mean vector with minimum quadratic risk is unsolved, even for normal distributions. Commonly used standard linear multivari­ ate procedures based on the inversion of sample covariance matrices can lead to unstable results or provide no solution in dependence of data. Programs included in standard statistical packages cannot process 'multi-collinear data' and there are no theoretical recommen­ ...

Applied multivariate statistical analysis

CERN Document Server

Härdle, Wolfgang Karl

2015-01-01

Focusing on high-dimensional applications, this 4th edition presents the tools and concepts used in multivariate data analysis in a style that is also accessible for non-mathematicians and practitioners.  It surveys the basic principles and emphasizes both exploratory and inferential statistics; a new chapter on Variable Selection (Lasso, SCAD and Elastic Net) has also been added.  All chapters include practical exercises that highlight applications in different multivariate data analysis fields: in quantitative financial studies, where the joint dynamics of assets are observed; in medicine, where recorded observations of subjects in different locations form the basis for reliable diagnoses and medication; and in quantitative marketing, where consumers’ preferences are collected in order to construct models of consumer behavior.  All of these examples involve high to ultra-high dimensions and represent a number of major fields in big data analysis. The fourth edition of this book on Applied Multivariate ...

Dual market structures and the likelihood of repeated ties - evidence from pharmaceutical biotechnology

NARCIS (Netherlands)

Roijakkers, A.H.W.M.; Hagedoorn, J.; Kranenburg, van H.

2005-01-01

This paper analyses the role of repeated ties in the high-tech pharmaceutical biotechnology industry, a sector that is characterized by a strong dual market structure. Our most important finding is that previous ties in pairs of large pharmaceutical companies and small biotechnology firms have a

A Single-Phase Transformerless Inverter With Charge Pump Circuit Concept for Grid-Tied PV Applications

DEFF Research Database (Denmark)

Ardashir, Jaber Fallah; Sabahi, Mehran; Hosseini, Seyed Hossein

2017-01-01

This paper proposes a new single-phase transformerless photovoltaic (PV) inverter for grid-tied PV systems. The topology is derived from the concept of a charge pump circuit in order to eliminate the leakage current. It is composed of four power switches, two diodes, two capacitors, and an LCL...... resonant control strategy is used to control the injected current. The main benefits of the proposed inverter are: the neutral of the grid is directly connected to the negative terminal of the PV panel, so the leakage current is eliminated; its compact size; low cost; the used dc voltage of the proposed...... are presented. Experimental results are presented to confirm both the theoretical analysis and the concept of the proposed inverter. The obtained results clearly validate the performance of the proposed inverter and its practical application in grid-tied PV systems....

Statistical evaluation of vibration analysis techniques

Science.gov (United States)

Milner, G. Martin; Miller, Patrice S.

1987-01-01

An evaluation methodology is presented for a selection of candidate vibration analysis techniques applicable to machinery representative of the environmental control and life support system of advanced spacecraft; illustrative results are given. Attention is given to the statistical analysis of small sample experiments, the quantification of detection performance for diverse techniques through the computation of probability of detection versus probability of false alarm, and the quantification of diagnostic performance.

HistFitter software framework for statistical data analysis

CERN Document Server

Baak, M.; Côte, D.; Koutsman, A.; Lorenz, J.; Short, D.

2015-01-01

We present a software framework for statistical data analysis, called HistFitter, that has been used extensively by the ATLAS Collaboration to analyze big datasets originating from proton-proton collisions at the Large Hadron Collider at CERN. Since 2012 HistFitter has been the standard statistical tool in searches for supersymmetric particles performed by ATLAS. HistFitter is a programmable and flexible framework to build, book-keep, fit, interpret and present results of data models of nearly arbitrary complexity. Starting from an object-oriented configuration, defined by users, the framework builds probability density functions that are automatically fitted to data and interpreted with statistical tests. A key innovation of HistFitter is its design, which is rooted in core analysis strategies of particle physics. The concepts of control, signal and validation regions are woven into its very fabric. These are progressively treated with statistically rigorous built-in methods. Being capable of working with mu...

Impact of Cross-Tie Properties on the Modal Behavior of Cable Networks on Cable-Stayed Bridges.

Science.gov (United States)

Ahmad, Javaid; Cheng, Shaohong; Ghrib, Faouzi

2015-01-01

Dynamic behaviour of cable networks is highly dependent on the installation location, stiffness, and damping of cross-ties. Thus, these are the important design parameters for a cable network. While the effects of the former two on the network response have been investigated to some extent in the past, the impact of cross-tie damping has rarely been addressed. To comprehend our knowledge of mechanics associated with cable networks, in the current study, an analytical model of a cable network will be proposed by taking into account both cross-tie stiffness and damping. In addition, the damping property of main cables in the network will also be considered in the formulation. This would allow exploring not only the effectiveness of a cross-tie design on enhancing the in-plane stiffness of a constituted cable network, but also its energy dissipation capacity. The proposed analytical model will be applied to networks with different configurations. The influence of cross-tie stiffness and damping on the modal response of various types of networks will be investigated by using the corresponding undamped rigid cross-tie network as a reference base. Results will provide valuable information on the selection of cross-tie properties to achieve more effective cable vibration control.

Impact of Cross-Tie Properties on the Modal Behavior of Cable Networks on Cable-Stayed Bridges

Directory of Open Access Journals (Sweden)

Javaid Ahmad

2015-01-01

Full Text Available Dynamic behaviour of cable networks is highly dependent on the installation location, stiffness, and damping of cross-ties. Thus, these are the important design parameters for a cable network. While the effects of the former two on the network response have been investigated to some extent in the past, the impact of cross-tie damping has rarely been addressed. To comprehend our knowledge of mechanics associated with cable networks, in the current study, an analytical model of a cable network will be proposed by taking into account both cross-tie stiffness and damping. In addition, the damping property of main cables in the network will also be considered in the formulation. This would allow exploring not only the effectiveness of a cross-tie design on enhancing the in-plane stiffness of a constituted cable network, but also its energy dissipation capacity. The proposed analytical model will be applied to networks with different configurations. The influence of cross-tie stiffness and damping on the modal response of various types of networks will be investigated by using the corresponding undamped rigid cross-tie network as a reference base. Results will provide valuable information on the selection of cross-tie properties to achieve more effective cable vibration control.

The rational weakness of strong ties : Failure of group solidarity in a highly cohesive group of rational agents

NARCIS (Netherlands)

Flache, Andreas

2002-01-01

Recent research (Flache, 1996; Flache and Macy, 1996) suggests a "weakness of strong ties." Cohesive social networks may undermine group solidarity, rather than sustain it. In the original analysis, simulations showed that adaptive actors learn cooperation in bilateral exchanges faster than

The rational weakness of strong ties : Failure of group solidarity in a highly cohesive group of rational agents

NARCIS (Netherlands)

Flache, A; Yamamoto, H

2006-01-01

Recent research (Flache 1996; Flache and Macy 1996) suggests a "weakness of strong ties." Cohesive social networks may undermine group solidarity, rather than sustain it. In the original analysis, simulations showed that adaptive actors learn cooperation in bilateral exchanges faster than

Statistical analysis on extreme wave height

Digital Repository Service at National Institute of Oceanography (India)

Teena, N.V.; SanilKumar, V.; Sudheesh, K.; Sajeev, R.

-294. • WAFO (2000) – A MATLAB toolbox for analysis of random waves and loads, Lund University, Sweden, homepage http://www.maths.lth.se/matstat/wafo/,2000. 15    Table 1: Statistical results of data and fitted distribution for cumulative distribution...

Linkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE).

Science.gov (United States)

Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on ...

Statistical Analysis of Zebrafish Locomotor Response.

Science.gov (United States)

Liu, Yiwen; Carmer, Robert; Zhang, Gaonan; Venkatraman, Prahatha; Brown, Skye Ashton; Pang, Chi-Pui; Zhang, Mingzhi; Ma, Ping; Leung, Yuk Fai

2015-01-01

Zebrafish larvae display rich locomotor behaviour upon external stimulation. The movement can be simultaneously tracked from many larvae arranged in multi-well plates. The resulting time-series locomotor data have been used to reveal new insights into neurobiology and pharmacology. However, the data are of large scale, and the corresponding locomotor behavior is affected by multiple factors. These issues pose a statistical challenge for comparing larval activities. To address this gap, this study has analyzed a visually-driven locomotor behaviour named the visual motor response (VMR) by the Hotelling's T-squared test. This test is congruent with comparing locomotor profiles from a time period. Different wild-type (WT) strains were compared using the test, which shows that they responded differently to light change at different developmental stages. The performance of this test was evaluated by a power analysis, which shows that the test was sensitive for detecting differences between experimental groups with sample numbers that were commonly used in various studies. In addition, this study investigated the effects of various factors that might affect the VMR by multivariate analysis of variance (MANOVA). The results indicate that the larval activity was generally affected by stage, light stimulus, their interaction, and location in the plate. Nonetheless, different factors affected larval activity differently over time, as indicated by a dynamical analysis of the activity at each second. Intriguingly, this analysis also shows that biological and technical repeats had negligible effect on larval activity. This finding is consistent with that from the Hotelling's T-squared test, and suggests that experimental repeats can be combined to enhance statistical power. Together, these investigations have established a statistical framework for analyzing VMR data, a framework that should be generally applicable to other locomotor data with similar structure.

Weizmann ties with Cambridge in physics contest

CERN Multimedia

Siegel, J

2004-01-01

"Scientists and students from the Weizmann Institute of Science in Rehovot and Cambridge University in England have tied for first place in a physics competition aimed at simulating the future functioning of the particle accelerator being built at the European center CERN and due to open in 2007" (1/2 page)

Time Series Analysis Based on Running Mann Whitney Z Statistics

Science.gov (United States)

A sensitive and objective time series analysis method based on the calculation of Mann Whitney U statistics is described. This method samples data rankings over moving time windows, converts those samples to Mann-Whitney U statistics, and then normalizes the U statistics to Z statistics using Monte-...

Mobile devices and weak ties: a study of vision impairments and workplace access in Bangalore.

Science.gov (United States)

Pal, Joyojeet; Lakshmanan, Meera

2015-07-01

To explore ways in which social and economic interactions are changed by access to mobile telephony. This is a mixed-methods study of mobile phone use among 52 urban professionals with vision impairments in Bangalore, India. Interviews and survey results indicated that mobile devices, specifically those with adaptive technology software, play a vital role as multi-purpose devices that enable people with disabilities to navigate economically and socially in an environment where accessibility remains a significant challenge. We found that mobile devices play a central role in enabling and sustaining weak ties, but also that these weak ties have important gender-specific implications. We found that women have less access to weak ties than men, which impacts women's access to assistive technology (AT). This has potential implications for women's sense of safety and independence, both of which are strongly related to AT access. Implications for Rehabilitation Adaptive technologies increase individuals' ability to keep in contact with casual connections or weak ties through phone calls or social media. Men tend to have stronger access to weak ties than women in India due to cultural impediments to independent access to public spaces. Weak ties are an important source of assistive technology (AT) due to the high rate of resale of used AT, typically through informal networks.

Sensitivity analysis of ranked data: from order statistics to quantiles

NARCIS (Netherlands)

Heidergott, B.F.; Volk-Makarewicz, W.

2015-01-01

In this paper we provide the mathematical theory for sensitivity analysis of order statistics of continuous random variables, where the sensitivity is with respect to a distributional parameter. Sensitivity analysis of order statistics over a finite number of observations is discussed before

Effects of a Group Intervention on the Career Network Ties of Finnish Adolescents

Science.gov (United States)

Jokisaari, Markku; Vuori, Jukka

2011-01-01

The authors evaluated how a group-based career intervention affected career network ties among Finnish adolescents as they made educational choices and prepared for their transition to secondary education. They examined the career-related network ties of 868 students during their last year in comprehensive school (junior high school) in a…

The VEGF system and tie-2 are spatio-temporal expressed during tayassu placentation

DEFF Research Database (Denmark)

Miglino, M.A.; Santos, T.C.; Papa, P.C.

Objectives: The vascular endothelial growth factor (VEGF) is one of the most important vascular mitogens, while the angiotensin receptor Tie-2 binds to the angiopoietin and stabilizes newly formed vessels. We therefore wanted to localize VEGF and its receptors VEGF-R1, VEGF-R2 and the Tie-2 recep...

The use of nylon cable ties to repair rib fractures in neonatal foals

OpenAIRE

Downs, Chris; Rodgerson, Dwayne

2011-01-01

Commercially available nylon cable ties were used as a method of internal fixation for displaced rib fractures in 8 equine neonates. The procedure was effective, well-tolerated, rapid, and inexpensive. The use of nylon cable ties as internal fixation for displaced rib fractures in foals is an effective surgical procedure.

A Technology Integration Education (TIE) Model: Millennial Preservice Teachers' Motivations about Technological, Pedagogical, and Content Knowledge (TPACK) Competencies

Science.gov (United States)

Holland, Denise D.; Piper, Randy T.

2014-01-01

Nobel laureates Schultz (1971) and Becker (1964, 1993) reinvigorated the analysis of education investments. Human capital investments that improve cognitive skills for elementary and secondary students have important economic implications. An interdisciplinary, 12-construct technology integration education (TIE) model was developed. The sample…

Comparison of frictional resistance between self-ligating and conventional brackets tied with elastomeric and metal ligature in orthodontic archwires.

Science.gov (United States)

Leite, Vanessa Vieira; Lopes, Murilo Baena; Gonini Júnior, Alcides; Almeida, Marcio Rodrigues de; Moura, Sandra Kiss; Almeida, Renato Rodrigues de

2014-01-01

To compare the frictional resistance between self-ligating and conventional brackets tied to different types of wire. Abzil Kirium Capelozza (Pattern I) and Easy Clip (Roth prescription) incisor brackets were used. An elastomeric ligature or a 0.10-in ligating wire was used to ligate the wire to the Abzil bracket. Three types of orthodontic archwire alloys were assessed: 0.016-in NiTi wire, 0.016 x 0.021-in NiTi wire and 0.019 x 0.025-in steel wire. Ten observations were carried out for each bracket-archwire angulation combination. Brackets were mounted in a special appliance, positioned at 90 degrees in relation to the wire and tested in two angulations. Frictional test was performed in a Universal Testing Machine at 5 mm/min and 10 mm of displacement. The means (MPa) were submitted to ANOVA and Tukey's test set at 5% of significance. The surfaces of wires and brackets were observed at SEM. Steel-tied brackets (16.48 ± 8.31) showed higher means of frictional resistance than elastomeric-tied brackets (4.29 ± 2.16 ) and self-ligating brackets (1.66 ± 1.57) (P 0.05). No statistical differences (P > 0.05) were found between zero (7.76 ± 8.46) and five-degree (7.19 ± 7.93) angulations. Friction was influenced not only by the type of bracket, but also by the ligating systems. Different morphological aspects were observed for the brackets and wires studied.

Performance and Characterization of Shear Ties for Use in Insulated Precast Concrete Sandwich Wall Panels

Science.gov (United States)

2010-11-01

stainless 14 steel, galvanized carbon steel, carbon- fiber -reinforced polymer (CFRP), glass- fiber -reinforced polymer 15 (GFRP), and basalt - fiber ...CFRP Grid, (E) Universal Building Products GFRP Teplo Tie, and (F) Universal Building Products 6 Basalt FRP RockBar. Traditional steel connections...1.6 E Universal Building Products TeploTie GFRP Tie 10 mm dia. x 150 mm F RockBar Basalt FRP Bar 7 in. x 5/16 in. G TSA Manufacturing C-Clip

Evaluation of Shear Tie Connectors for Use in Insulated Concrete Sandwich Panels

Science.gov (United States)

2009-12-01

stainless steel, galvanized carbon steel, carbon fiber reinforced polymers (CFRP), glass fiber reinforced polymer (GFRP), and basalt fiber reinforced polymer...Glass Fiber Reinforced Polymer (GFRP) Delta Tie produced by Dayton Superior; • (B) THERMOMASS® composite GFRP pins; • (C) THERMOMASS® non-composite...GFRP pins; • (D) Altus Group CFRP Grid; • (E) Universal Building products GFRP Teplo Tie; and • (F) Universal Building products Basalt FRP

The Strength of Weak Ties in MBA Job Search: A Within–Person Test

Directory of Open Access Journals (Sweden)

Jason Greenberg

2016-05-01

Full Text Available Whether and how social ties create value has inspired substantial research in organizational theory, sociology, and economics. Scholars generally believe that social ties impact labor market outcomes. Two explanatory mechanisms have been identified, emphasizing access to better job offers in pecuniary terms and the efficacy of non-redundant information. The evidence informing each theory, however, has been inconsistent and circumstantial. We test predictions from both models using a rich set of job search data collected from an MBA student population, including detailed information about search channels and characteristics of job offers. Importantly, we can compare offers made to the same student derived via different search channels while accounting for industry, function, and non-pecuniary characteristics. We find that contrary to conventional wisdom, search through social networks typically results in job offers with lower total compensation (-17 percent for referrals through strong ties and -16 percent for referrals via weak ties vs. formal search. However, our models also show that students are considerably more likely to accept offers derived via weak ties. They do so because they are perceived to have greater growth potential and other non-pecuniary value. On balance, our tests are consistent with Granovetter’s argument that networks provide value by facilitating access to information that is otherwise difficult to obtain, rather than providing greater pecuniary compensation.

Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study

Directory of Open Access Journals (Sweden)

Wagner Ludwig

2011-06-01

Full Text Available Abstract Background Type 2 diabetes is associated with increased levels of Angiopoietin-2 (Ang-2 and soluble Tie-2 (sTie-2, but its impact on vascular disease is still unknown. This study aimed to further explore the associations of Ang-2 and sTie-2 with metabolic control and diabetic complications. Methods In a cross-sectional designed study, levels of Ang-2 and sTie-2 as well as their relationships to cardiometabolic parameters were determined in 80 type 2 diabetic subjects (age 65 ± 7 years, female 47.4%. Results After controlling for age and BMI, Ang-2 levels were associated with levels of sTie-2, diastolic blood pressure, plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR, creatinine, glomerular filtration rate (GFR, and gamma-glutamyl transferase (GGT (all p 1c, fasting plasma glucose and insulin, HOMA-IR, triglyceride, and liver function parameters (all p 1c, insulin levels, and HOMA-IR (p Conclusions Ang-2 is independently associated with levels of GGT while sTie-2 is independently associated with levels of HbA1c, plasma insulin and HOMA-IR in type 2 diabetic subjects. Therefore we suggest that the associations of Ang-2 and sTie-2 with type 2 diabetes are based on different patho-physiological mechanisms.

Feature-Based Statistical Analysis of Combustion Simulation Data

Energy Technology Data Exchange (ETDEWEB)

Bennett, J; Krishnamoorthy, V; Liu, S; Grout, R; Hawkes, E; Chen, J; Pascucci, V; Bremer, P T

2011-11-18

We present a new framework for feature-based statistical analysis of large-scale scientific data and demonstrate its effectiveness by analyzing features from Direct Numerical Simulations (DNS) of turbulent combustion. Turbulent flows are ubiquitous and account for transport and mixing processes in combustion, astrophysics, fusion, and climate modeling among other disciplines. They are also characterized by coherent structure or organized motion, i.e. nonlocal entities whose geometrical features can directly impact molecular mixing and reactive processes. While traditional multi-point statistics provide correlative information, they lack nonlocal structural information, and hence, fail to provide mechanistic causality information between organized fluid motion and mixing and reactive processes. Hence, it is of great interest to capture and track flow features and their statistics together with their correlation with relevant scalar quantities, e.g. temperature or species concentrations. In our approach we encode the set of all possible flow features by pre-computing merge trees augmented with attributes, such as statistical moments of various scalar fields, e.g. temperature, as well as length-scales computed via spectral analysis. The computation is performed in an efficient streaming manner in a pre-processing step and results in a collection of meta-data that is orders of magnitude smaller than the original simulation data. This meta-data is sufficient to support a fully flexible and interactive analysis of the features, allowing for arbitrary thresholds, providing per-feature statistics, and creating various global diagnostics such as Cumulative Density Functions (CDFs), histograms, or time-series. We combine the analysis with a rendering of the features in a linked-view browser that enables scientists to interactively explore, visualize, and analyze the equivalent of one terabyte of simulation data. We highlight the utility of this new framework for combustion

78 FR 25303 - Prestressed Concrete Steel Rail Tie Wire From China, Mexico, and Thailand

Science.gov (United States)

2013-04-30

... INTERNATIONAL TRADE COMMISSION [Investigation Nos. 731-TA-1207-1209 (Preliminary)] Prestressed Concrete Steel Rail Tie Wire From China, Mexico, and Thailand Institution of antidumping duty..., by reason of imports from prestressed concrete steel rail tie wire from China, Mexico, and Thailand...

78 FR 57619 - Prestressed Concrete Steel Rail Tie Wire From Mexico, Thailand, and the People's Republic of...

Science.gov (United States)

2013-09-19

...] Prestressed Concrete Steel Rail Tie Wire From Mexico, Thailand, and the People's Republic of China... prestressed concrete steel rail tie wire from Mexico, Thailand, and the People's Republic of China. See Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and Thailand: Initiation...

Statistical learning methods in high-energy and astrophysics analysis

Energy Technology Data Exchange (ETDEWEB)

Zimmermann, J. [Forschungszentrum Juelich GmbH, Zentrallabor fuer Elektronik, 52425 Juelich (Germany) and Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Munich (Germany)]. E-mail: zimmerm@mppmu.mpg.de; Kiesling, C. [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Munich (Germany)

2004-11-21

We discuss several popular statistical learning methods used in high-energy- and astro-physics analysis. After a short motivation for statistical learning we present the most popular algorithms and discuss several examples from current research in particle- and astro-physics. The statistical learning methods are compared with each other and with standard methods for the respective application.

Statistical learning methods in high-energy and astrophysics analysis

International Nuclear Information System (INIS)

Zimmermann, J.; Kiesling, C.

2004-01-01

We discuss several popular statistical learning methods used in high-energy- and astro-physics analysis. After a short motivation for statistical learning we present the most popular algorithms and discuss several examples from current research in particle- and astro-physics. The statistical learning methods are compared with each other and with standard methods for the respective application

The weak-ties in advanced business services as a major force of innovation and diffusion; Las Eak-Ties en los servicios avanzados a empresas como factor relevante de la innovacion y su difusion

Energy Technology Data Exchange (ETDEWEB)

Almenar i Llongo, V.; Hernandez Sancho, F.; Solar i Marco, V.

2012-07-01

This paper tries to expose the role of weak-ties of advanced business services in both mechanisms which generate innovation as well as allow technological diffusion and transfer of innovations (spillovers). Assuming that the latest information generally flows to agents through weak ties, the Weak-Ties Hypothesis (WTH) is an approach that helps to explain the importance of the relations with the environment in the process of innovation and generation of new knowledge and its implementation and dissemination, evaluating the synergy's resulting from cooperation between agents. (Author) 21 refs.

The fuzzy approach to statistical analysis

NARCIS (Netherlands)

Coppi, Renato; Gil, Maria A.; Kiers, Henk A. L.

2006-01-01

For the last decades, research studies have been developed in which a coalition of Fuzzy Sets Theory and Statistics has been established with different purposes. These namely are: (i) to introduce new data analysis problems in which the objective involves either fuzzy relationships or fuzzy terms;

Statistical analysis applied to safety culture self-assessment

International Nuclear Information System (INIS)

Macedo Soares, P.P.

2002-01-01

Interviews and opinion surveys are instruments used to assess the safety culture in an organization as part of the Safety Culture Enhancement Programme. Specific statistical tools are used to analyse the survey results. This paper presents an example of an opinion survey with the corresponding application of the statistical analysis and the conclusions obtained. Survey validation, Frequency statistics, Kolmogorov-Smirnov non-parametric test, Student (T-test) and ANOVA means comparison tests and LSD post-hoc multiple comparison test, are discussed. (author)

Family Ties and Young Fathers’ Engagement in Cape Town, South Africa

Science.gov (United States)

Clark, Shelley; Cotton, Cassandra; Marteleto, Leticia J.

2015-01-01

Young South African fathers are often engaged in their children’s lives even if they do not live together. Using longitudinal data on children (n = 1,209) from the Cape Town area, the authors show that although only 26% of young fathers live with their children, 66% of nonresidential fathers maintain regular contact, and 61% provide financial support. The father–child relationship, however, is embedded in broader family ties. The type of father–mother relationship is strongly associated with whether fathers coreside with their children, but not with fathers’ contact with nonresidential children. Close mother and maternal grandmother bonds reduce the likelihood that fathers live with their children, whereas close ties between fathers and paternal grandmothers increase the chance that fathers visit nonresidential children. Family ties do not affect fathers’ financial contributions, which are driven by men’s current economic situation. These findings illustrate that father–child relationships are best understood in the context of interacting family systems. PMID:25774066

Foundation of statistical energy analysis in vibroacoustics

CERN Document Server

Le Bot, A

2015-01-01

This title deals with the statistical theory of sound and vibration. The foundation of statistical energy analysis is presented in great detail. In the modal approach, an introduction to random vibration with application to complex systems having a large number of modes is provided. For the wave approach, the phenomena of propagation, group speed, and energy transport are extensively discussed. Particular emphasis is given to the emergence of diffuse field, the central concept of the theory.

Statistical Analysis of Big Data on Pharmacogenomics

Science.gov (United States)

Fan, Jianqing; Liu, Han

2013-01-01

This paper discusses statistical methods for estimating complex correlation structure from large pharmacogenomic datasets. We selectively review several prominent statistical methods for estimating large covariance matrix for understanding correlation structure, inverse covariance matrix for network modeling, large-scale simultaneous tests for selecting significantly differently expressed genes and proteins and genetic markers for complex diseases, and high dimensional variable selection for identifying important molecules for understanding molecule mechanisms in pharmacogenomics. Their applications to gene network estimation and biomarker selection are used to illustrate the methodological power. Several new challenges of Big data analysis, including complex data distribution, missing data, measurement error, spurious correlation, endogeneity, and the need for robust statistical methods, are also discussed. PMID:23602905

HistFitter software framework for statistical data analysis

Energy Technology Data Exchange (ETDEWEB)

Baak, M. [CERN, Geneva (Switzerland); Besjes, G.J. [Radboud University Nijmegen, Nijmegen (Netherlands); Nikhef, Amsterdam (Netherlands); Cote, D. [University of Texas, Arlington (United States); Koutsman, A. [TRIUMF, Vancouver (Canada); Lorenz, J. [Ludwig-Maximilians-Universitaet Muenchen, Munich (Germany); Excellence Cluster Universe, Garching (Germany); Short, D. [University of Oxford, Oxford (United Kingdom)

2015-04-15

We present a software framework for statistical data analysis, called HistFitter, that has been used extensively by the ATLAS Collaboration to analyze big datasets originating from proton-proton collisions at the Large Hadron Collider at CERN. Since 2012 HistFitter has been the standard statistical tool in searches for supersymmetric particles performed by ATLAS. HistFitter is a programmable and flexible framework to build, book-keep, fit, interpret and present results of data models of nearly arbitrary complexity. Starting from an object-oriented configuration, defined by users, the framework builds probability density functions that are automatically fit to data and interpreted with statistical tests. Internally HistFitter uses the statistics packages RooStats and HistFactory. A key innovation of HistFitter is its design, which is rooted in analysis strategies of particle physics. The concepts of control, signal and validation regions are woven into its fabric. These are progressively treated with statistically rigorous built-in methods. Being capable of working with multiple models at once that describe the data, HistFitter introduces an additional level of abstraction that allows for easy bookkeeping, manipulation and testing of large collections of signal hypotheses. Finally, HistFitter provides a collection of tools to present results with publication quality style through a simple command-line interface. (orig.)

HistFitter software framework for statistical data analysis

International Nuclear Information System (INIS)

Baak, M.; Besjes, G.J.; Cote, D.; Koutsman, A.; Lorenz, J.; Short, D.

2015-01-01

We present a software framework for statistical data analysis, called HistFitter, that has been used extensively by the ATLAS Collaboration to analyze big datasets originating from proton-proton collisions at the Large Hadron Collider at CERN. Since 2012 HistFitter has been the standard statistical tool in searches for supersymmetric particles performed by ATLAS. HistFitter is a programmable and flexible framework to build, book-keep, fit, interpret and present results of data models of nearly arbitrary complexity. Starting from an object-oriented configuration, defined by users, the framework builds probability density functions that are automatically fit to data and interpreted with statistical tests. Internally HistFitter uses the statistics packages RooStats and HistFactory. A key innovation of HistFitter is its design, which is rooted in analysis strategies of particle physics. The concepts of control, signal and validation regions are woven into its fabric. These are progressively treated with statistically rigorous built-in methods. Being capable of working with multiple models at once that describe the data, HistFitter introduces an additional level of abstraction that allows for easy bookkeeping, manipulation and testing of large collections of signal hypotheses. Finally, HistFitter provides a collection of tools to present results with publication quality style through a simple command-line interface. (orig.)

Robust statistics and geochemical data analysis

International Nuclear Information System (INIS)

Di, Z.

1987-01-01

Advantages of robust procedures over ordinary least-squares procedures in geochemical data analysis is demonstrated using NURE data from the Hot Springs Quadrangle, South Dakota, USA. Robust principal components analysis with 5% multivariate trimming successfully guarded the analysis against perturbations by outliers and increased the number of interpretable factors. Regression with SINE estimates significantly increased the goodness-of-fit of the regression and improved the correspondence of delineated anomalies with known uranium prospects. Because of the ubiquitous existence of outliers in geochemical data, robust statistical procedures are suggested as routine procedures to replace ordinary least-squares procedures

Frequency Adaptive Repetitive Control of Grid-Tied Three-Phase PV Inverters

DEFF Research Database (Denmark)

Zhou, Keliang; Yang, Yongheng; Blaabjerg, Frede

2016-01-01

Repetitive control offers an accurate current control scheme for grid-tied converters to feed high quality sinusoidal current into the grid. However, with grid frequency being treated as a constant value, conventional repetitive controller fail to produce high quality feeding current in the prese......Repetitive control offers an accurate current control scheme for grid-tied converters to feed high quality sinusoidal current into the grid. However, with grid frequency being treated as a constant value, conventional repetitive controller fail to produce high quality feeding current...

The Bright Side and Dark Side of Embedded Ties In Business-to-Business Innovation

NARCIS (Netherlands)

C.S. Noordhoff (Corine); K. Kyriakopoulos (Kyriakos); C. Moorman (Christina); P. Pauwels (Pieter); B.G.C. Dellaert (Benedict)

2011-01-01

textabstractWhile the number and importance of joint innovation projects between suppliers and their customers continue to rise, the literature has yet to resolve a key question—do embedded ties with customers help or hurt supplier innovation? Drawing on both the tie strength and knowledge

The bright side and dark side of embedded ties in business-to-business innovation

NARCIS (Netherlands)

C.S. Noordhoff (Corine); K. Kyriakopoulos (Kyriakos); C. Moorman (Christina); P. Pauwels (Pieter); B.G.C. Dellaert (Benedict)

2011-01-01

textabstractAlthough the number and importance of joint innovation projects between suppliers and their customers continue to rise, the literature has yet to resolve a key question: Do embedded ties with customers help or hurt supplier innovation? Drawing on both the tie strength and knowledge

Using Pre-Statistical Analysis to Streamline Monitoring Assessments

International Nuclear Information System (INIS)

Reed, J.K.

1999-01-01

A variety of statistical methods exist to aid evaluation of groundwater quality and subsequent decision making in regulatory programs. These methods are applied because of large temporal and spatial extrapolations commonly applied to these data. In short, statistical conclusions often serve as a surrogate for knowledge. However, facilities with mature monitoring programs that have generated abundant data have inherently less uncertainty because of the sheer quantity of analytical results. In these cases, statistical tests can be less important, and ''expert'' data analysis should assume an important screening role.The WSRC Environmental Protection Department, working with the General Separations Area BSRI Environmental Restoration project team has developed a method for an Integrated Hydrogeological Analysis (IHA) of historical water quality data from the F and H Seepage Basins groundwater remediation project. The IHA combines common sense analytical techniques and a GIS presentation that force direct interactive evaluation of the data. The IHA can perform multiple data analysis tasks required by the RCRA permit. These include: (1) Development of a groundwater quality baseline prior to remediation startup, (2) Targeting of constituents for removal from RCRA GWPS, (3) Targeting of constituents for removal from UIC, permit, (4) Targeting of constituents for reduced, (5)Targeting of monitoring wells not producing representative samples, (6) Reduction in statistical evaluation, and (7) Identification of contamination from other facilities

Conjunction analysis and propositional logic in fMRI data analysis using Bayesian statistics.

Science.gov (United States)

Rudert, Thomas; Lohmann, Gabriele

2008-12-01

To evaluate logical expressions over different effects in data analyses using the general linear model (GLM) and to evaluate logical expressions over different posterior probability maps (PPMs). In functional magnetic resonance imaging (fMRI) data analysis, the GLM was applied to estimate unknown regression parameters. Based on the GLM, Bayesian statistics can be used to determine the probability of conjunction, disjunction, implication, or any other arbitrary logical expression over different effects or contrast. For second-level inferences, PPMs from individual sessions or subjects are utilized. These PPMs can be combined to a logical expression and its probability can be computed. The methods proposed in this article are applied to data from a STROOP experiment and the methods are compared to conjunction analysis approaches for test-statistics. The combination of Bayesian statistics with propositional logic provides a new approach for data analyses in fMRI. Two different methods are introduced for propositional logic: the first for analyses using the GLM and the second for common inferences about different probability maps. The methods introduced extend the idea of conjunction analysis to a full propositional logic and adapt it from test-statistics to Bayesian statistics. The new approaches allow inferences that are not possible with known standard methods in fMRI. (c) 2008 Wiley-Liss, Inc.

Risk analysis using AS/NZS 4360:2004, Bow-Tie diagram and ALARP on construction projects of Banyumanik Hospital

Science.gov (United States)

Sari, Diana Puspita; Pujotomo, Darminto; Wardani, Nadira Kusuma

2017-11-01

The Determination of risk is an uncertain event. Risks can have negative or positive impacts on project objectives. A project was defined as a series of activities and tasks that have a purpose, specifications, and limits of cost. Banyumanik Hospital Development Project is one of the construction projects in Semarang which have experienced some problems. The first problem is project delays on building stake. The second problem is delay of material supply. Finally, the problem that occurs is less management attention to health safety as evidenced by the unavailability of PPE for the workers. These problems will pose a risk to be a very important risk management performed by contractors at the Banyumanik Hospital Development Project to reduce the impact that would be caused by the risk borne by the provider of construction services. This research aim to risk identification, risk assessment and risk mitigation. Project risk management begins with the identification of risks based on the project life cycle. The risk assessment carried out by AS I NZS 4360: 2004 to the impacts of cost, time and quality. The results obtained from the method of AS I NZS 4360: 2004 is the risk that requires the handling of mitigation. Mitigated risk is the risk that had significant and high level. There are four risks that require risk mitigation with Bow-Tie diagrams which is work accidents, contract delays, material delays and design changes. Bow-Tie diagram method is a method for identifying causal and preventive action and recovery of a risk. Results obtained from Bow-Tie diagram method is a preventive action and recovery. This action is used as input to the ALARP method. ALARP method is used to determine the priority of the strategy proposed in the category broadly acceptable, tolerable, and unacceptable.

Multi-area economic dispatch with tie-line constraints employing ...

African Journals Online (AJOL)

user

The economic dispatch problem is frequently solved without considering ... programming algorithm was proposed for the MAED solution with tie-line constraints ..... are the difference between two randomly chosen parameter vectors, a concept.

Experimental Effects of Program Management Approach on Teachers' Professional Ties and Social Capital

Science.gov (United States)

Quinn, David M.; Kim, James S.

2018-01-01

Theory and empirical work suggest that teachers' social capital influences school improvement efforts. Social ties are prerequisite for social capital, yet little causal evidence exists on how malleable factors, such as instructional management approaches, affect teachers' ties. In this cluster-randomized trial, we apply a decision-making…

78 FR 37236 - Prestressed Concrete Steel Rail Tie Wire From China, Mexico, and Thailand

Science.gov (United States)

2013-06-20

... Concrete Steel Rail Tie Wire From China, Mexico, and Thailand Determinations On the basis of the record \\1... imports from China, Mexico, and Thailand of prestressed concrete steel rail tie wire, provided for in... China, Mexico, and Thailand. Accordingly, effective April 23, 2013, the Commission instituted...

The Importance of External Contacts in Job Performance: A Study in Healthcare Organizations Using Social Network Analysis

Directory of Open Access Journals (Sweden)

Pilar Marqués-Sánchez

2018-06-01

Full Text Available There is evidence that relations between physicians and nurses within healthcare institutions might be shaped by informal aspects of such relations and by links to people external to the organization, with an impact on work performance. Social network analysis is underutilized in exploring such associations. The paper aims to describe physicians’ and nurses’ relationships outside their clinical units and to explore what kind of ties are related to job performance. A network analysis was performed on cross-sectional data. The study population consisted of 196 healthcare employees working in a public hospital and a primary healthcare centre in Spain. Relational data were analysed using the UCINET software package. Measures included: (i sample characteristics; (ii social network variables; and (iii team performance ratings. Descriptive statistics (means, medians, percentages were used to characterize staff and performance ratings. A correlational analysis was conducted to examine the strength of relationships between four different types of ties. Our findings suggest that external ties only contribute to improving the performance of physicians at both the individual and team level. They are focused on the decision-making process about the therapeutic plan and, therefore, might need to seek advice outside the workplace. In contrast, external ties are not relevant for the work performance of nurses, as they need to find solutions to immediate problems in a short period of time, having strong ties in the workplace. Social network analysis can illuminate relations within healthcare organizations and inform the development of innovative interventions.

Affective social ties - missing link in governance theory

NARCIS (Netherlands)

van Winden, F.A.A.M.

2012-01-01

Although governance is about interpersonal relationships, it appears that the antecedents and consequences of affective bonds (social ties) in social groups dealing with common-pool resources and public goods have been neglected. The welfare costs of the neglect of such bonds and their dynamic

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1

Directory of Open Access Journals (Sweden)

Chaohuan Luo

2016-11-01

Full Text Available Background/Aims: Hyperuricemia is part of the metabolic-syndrome cluster of abdominal obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension. Monocytes/macrophages are critical in the development of metabolic syndrome, including gout, obesity and atherosclerosis. However, how high uric acid (HUA exposure affects monocyte/macrophage function remains unclear. In this study, we investigated the molecular mechanism of HUA exposure in monocytes/macrophages and its impact on oxidized low-density lipoprotein (oxLDL-induced foam-cell formation in a human monocytic cell line, THP-1. Methods: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS and analyzed the level of phospho-AMPKα. THP-1 cells were pre-incubated with Compound C, an AMPK inhibitor, or N-acetyl-L-cysteine (NAC, a ROS scavenger, or HUA before PMA, to assess CD68 expression and phospho-AMPKα level. PMA-primed THP-1 cells were pre-treated with oxLDL before Compound C and HUA treatment. Western blot analysis was used to examine the levels of phospho-AMPKα, CD68, ABCG1, ABCA1, cyclooxygenase-2 (COX-2 and NF-κB (p65. Flow cytometry was used to assess ROS production and CD68 expression in live cells. Oil-red O staining was used to observe oxLDL uptake in cells. Results: HUA treatment increased ROS production in PMA-primed THP-1 cells; NAC blocked HUA-induced oxidative stress. HUA treatment time-dependently increased phospho-AMPKα level in PMA-primed THP-1 cells. The HUA-induced oxidative stress increased phospho-AMPKα levels, which was blocked by NAC. HUA treatment impaired CD68 expression during cell differentiation by activating the AMPK pathway, which was reversed by Compound C treatment. Finally, HUA treatment inhibited oxLDL uptake in the formation of foam cells in THP-1 cells, which was blocked by Compound C treatment. HUA treatment

Sensitivity analysis and optimization of system dynamics models : Regression analysis and statistical design of experiments

NARCIS (Netherlands)

Kleijnen, J.P.C.

1995-01-01

This tutorial discusses what-if analysis and optimization of System Dynamics models. These problems are solved, using the statistical techniques of regression analysis and design of experiments (DOE). These issues are illustrated by applying the statistical techniques to a System Dynamics model for

Development and Testing of a Prototype Grid-Tied Photovoltaic Power System

Science.gov (United States)

Eichenberg, Dennis J.

2009-01-01

The NASA Glenn Research Center (GRC) has developed and tested a prototype 2 kW DC grid-tied photovoltaic (PV) power system at the Center. The PV system has generated in excess of 6700 kWh since operation commenced in July 2006. The PV system is providing power to the GRC grid for use by all. Operation of the prototype PV system has been completely trouble free. A grid-tied PV power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. The project transfers space technology to terrestrial use via nontraditional partners. GRC personnel glean valuable experience with PV power systems that are directly applicable to various space power systems, and provide valuable space program test data. PV power systems help to reduce harmful emissions and reduce the Nation s dependence on fossil fuels. Power generated by the PV system reduces the GRC utility demand, and the surplus power aids the community. Present global energy concerns reinforce the need for the development of alternative energy systems. Modern PV panels are readily available, reliable, efficient, and economical with a life expectancy of at least 25 years. Modern electronics has been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy of at least 25 years. Based upon the success of the prototype PV system, additional PV power system expansion at GRC is under consideration. The prototype grid-tied PV power system was successfully designed and developed which served to validate the basic principles described, and the theoretical work that was performed. The report concludes that grid-tied photovoltaic power systems are reliable, maintenance free, long life power systems, and are of significant value to NASA and the community.

Multivariate Statistical Methods as a Tool of Financial Analysis of Farm Business

Czech Academy of Sciences Publication Activity Database

Novák, J.; Sůvová, H.; Vondráček, Jiří

2002-01-01

Roč. 48, č. 1 (2002), s. 9-12 ISSN 0139-570X Institutional research plan: AV0Z1030915 Keywords : financial analysis * financial ratios * multivariate statistical methods * correlation analysis * discriminant analysis * cluster analysis Subject RIV: BB - Applied Statistics, Operational Research

Statistical analysis and interpretation of prenatal diagnostic imaging studies, Part 2: descriptive and inferential statistical methods.

Science.gov (United States)

Tuuli, Methodius G; Odibo, Anthony O

2011-08-01

The objective of this article is to discuss the rationale for common statistical tests used for the analysis and interpretation of prenatal diagnostic imaging studies. Examples from the literature are used to illustrate descriptive and inferential statistics. The uses and limitations of linear and logistic regression analyses are discussed in detail.

Building ties: social capital network analysis of a forest community in a biosphere reserve in Chiapas, Mexico

Directory of Open Access Journals (Sweden)

Luis Rico García-Amado

2012-09-01

Full Text Available Governance of the commons depends on the capacity to generate collective action. Networks and rules that foster that collective action have been defined as social capital. However, their causal link is still not fully understood. We use social network analysis to assess social capital, decision-making, and collective action in a forest-based common pool resource management in La Sepultura Biosphere Reserve (Chiapas, Mexico. Our research analyzes the productive networks and the evolution of coffee groups in one community. The network shows some centrality, with richer landholders tending to occupy core positions and poorer landless peasants occupying peripheral ones. This has fostered the community's environmentally oriented development but has also caused internal conflicts. Market requirements have shaped different but complementary productive networks, where organic coffee commercialization is the main source of bridging ties, which has resulted in more connectivity and resilience. Conservation attitudes, along with the institutional setting of the community, have promoted collective action. The unresolved conflicts, however, still leave some concerns about governance in the future.

Changes of Personal Network Composition and Inter-Group Ties from 1987 to 2005 in Hungary

Directory of Open Access Journals (Sweden)

VARGA V., Attila

2014-04-01

Full Text Available The following paper presents the changes and stability of assortative mixing, and inter-group ties in Hungary from 1987 to 2005. The demographic categories under investigation are age, sex, and education. The analysis has a special focus on the rearrangement of the context of tie formation, and the inequality of receiving choices into personal networks along social categories. The most substantial change during the period, is the strong decrease in gender homophily, and some strengthening of intergenerationalties. Both of these findings are in line with the observation that personal networks are recruited more often among the members of the nuclear-family. This latter phenomenon is probably due to the shrinking network size. However, this set of finding is prone to the methodological criticism formulated in the US context, that these observations are in fact the result of the interviewer effect. Finally, the study found stable patterns of educational network prestige, and describes the changes of social capital attached to categories of gender and age.

Statistical analysis of environmental data

International Nuclear Information System (INIS)

Beauchamp, J.J.; Bowman, K.O.; Miller, F.L. Jr.

1975-10-01

This report summarizes the analyses of data obtained by the Radiological Hygiene Branch of the Tennessee Valley Authority from samples taken around the Browns Ferry Nuclear Plant located in Northern Alabama. The data collection was begun in 1968 and a wide variety of types of samples have been gathered on a regular basis. The statistical analysis of environmental data involving very low-levels of radioactivity is discussed. Applications of computer calculations for data processing are described

Clinical evaluation of the endothelial tie-2 crossmatch in ABO compatible and ABO incompatible renal transplants.

Science.gov (United States)

Kafetzi, Maria L; Boletis, John N; Melexopoulou, Christine A; Tsakris, Athanassios; Iniotaki, Aliki G; Doxiadis, Ilias I N

2013-11-01

The necessity of detection of other than the classical major histocompatibility complex (MHC) and MHC class I-related chain A (MICA) directed antibodies prior to organ transplantation has already been repeatedly reported. A commercial flow cytometric endothelial crossmatch (CM) using isolated peripheral blood tie-2 positive cells provides a tool to detect non-MHC antibodies in addition to antibodies directed to MHC class I and II. The vast majority of circulating tie-2 positive cells expresses HLA-DR but not the A, B blood group antigens. Tie-2 cells are circulating surrogate endothelial cells. In this retrospective study we evaluated the endothelial CM in 51 renal transplantations, 30 with ABO compatible grafts and 21 with ABO incompatible grafts. Fifteen of the ABO compatible recipients (group A) developed unexplained rejection episodes (RE) while the remaining 15 had no RE (group B). Five cases of group A and none of group B had a positive tie-2 CM before transplantation (p=0.042). A positive tie-2 CM was also correlated with graft failure in ABO compatible transplants (p=0.02). No significant correlation was found between a positive pre-transplant tie-2 CM and RE in the ABO incompatible group. This study strongly suggest that a positive tie-2 CM may predict post-transplantation complications in ABO compatible grafts while negative reactions are not predictive. The test is not significantly correlated with RE in ABO incompatible grafts possibly due to applied desensitization. Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Representation of Women With Industry Ties in Ophthalmology.

Science.gov (United States)

Reddy, Ashvini K; Bounds, Gregory W; Bakri, Sophie J; Gordon, Lynn K; Smith, Justine R; Haller, Julia A; Thorne, Jennifer E

2016-06-01

Women in ophthalmology are growing in number and have made strides in traditional metrics of professional achievement. Professional ties to industry represent another potential means of career advancement, recognition, and income. To report the representation of women among ophthalmologists receiving industry remuneration for research, consulting, honoraria, grants, royalties, and faculty/speaker roles. In this observational, retrospective study, the Centers for Medicare and Medicaid Services Open Payments database for payments to ophthalmologists by biomedical companies was reviewed for representation, median payments, and mean payments by women and men for industry relationships in 2013 and 2014. The analysis was performed from July 2015 to November 2015. The primary outcome measures were percentage representation of women vs men overall and in industry research, consulting, speaking roles, royalties and licenses, grants, services other than consulting, and honoraria. Secondary outcome measures included mean and median payments from industry to female vs male ophthalmologists. In 2013, 4164 of 21 380 (19.5%) ophthalmologists were women, and of 1204 ophthalmologists analyzed for industry payments, 176 (4.2%) women had industry ties compared with 1028 (6%) men (P women were $11 419 compared with $20 957 for men (P = .001), and median payments to women were $3000 compared with $4787 for men (P = .007). In 2013, women were underrepresented among ophthalmologists receiving industry payments for research (49 of 462 [10.6%]), consulting (96 of 610 [15.7%]), honoraria (3 of 47 [6.4%]), industry grants (1 of 7 [14.3%]), royalties and licenses (1 of 13 [7.7%]), and faculty/speaker roles (2 of 48 [4.2%]). In 2014, 4352 of 21 531 (20.2%) of ophthalmologists were women. Of 1518 ophthalmologists analyzed for industry payments, 255 (6%) women had industry ties compared with 1263 (7.4%) men (P women were $14 848 compared with $30 513 for men (P = .004

When community ties lead to violent crimes | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

2017-10-20

Oct 20, 2017 ... Exploring social cohesion and mistrust of the state as drivers of urban ... Evidence suggests that these ties help communities to self-organize and .... acts while weakening social interactions and bonds between neighbours.

Highly Robust Statistical Methods in Medical Image Analysis

Czech Academy of Sciences Publication Activity Database

Kalina, Jan

2012-01-01

Roč. 32, č. 2 (2012), s. 3-16 ISSN 0208-5216 R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : robust statistics * classification * faces * robust image analysis * forensic science Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.208, year: 2012 http://www.ibib.waw.pl/bbe/bbefulltext/BBE_32_2_003_FT.pdf

Nonlinear Price Schedules and Tied Products.

OpenAIRE

Ormiston, Michael B; Phillips, Owen R

1988-01-01

Illegal tying often occurs when a monopolist jointly sells a product with a complementary requirement, also sold competitively. Along with selling the complement at its competi tive price, this paper shows that profit can increase when a monopoli st lets consumers bundle any amount of the requirement with the basic product at a fixed price. Examples illustrate demand conditions that enhance the profitability of this nonlinear price strategy and show that profits can approximate those earned f...

Mobile communication and network privatism: A literature review of the implications for diverse, weak, and new ties

Directory of Open Access Journals (Sweden)

Scott W. Campbell

2015-01-01

Full Text Available Most of the research on the implications of mobile communication for social networks has focused on its uses and consequences in the intimate realm of close friends, family, and loved ones. A number of scholars have also become interested in ways that mobile communication helps and hinders the broader realm of network connectivity, including diverse, weak, and new ties. A collection of theoretical perspectives on mobile communication and diverse, weak, and new ties proposes that heightened connectivity in the intimate realm can come at the expense of being engaged more broadly – a scenario I characterize as network privatism. At the same time, the available empirical research in the literature tends to tell a different story, or rather stories. This analysis brings theory and empirical findings into closer conversation with one another by reviewing and synthesizing the literature in this area. Observed patterns in the literature offer new insight into questions of mobile communication and network privatism, while also pointing to opportunities for refinement of theory, analysis, and measurement as this line of inquiry further develops.

Statistical Power Analysis with Missing Data A Structural Equation Modeling Approach

CERN Document Server

Davey, Adam

2009-01-01

Statistical power analysis has revolutionized the ways in which we conduct and evaluate research.  Similar developments in the statistical analysis of incomplete (missing) data are gaining more widespread applications. This volume brings statistical power and incomplete data together under a common framework, in a way that is readily accessible to those with only an introductory familiarity with structural equation modeling.  It answers many practical questions such as: How missing data affects the statistical power in a study How much power is likely with different amounts and types

Let the Weakest Link Go! Empirical Explorations on the Relative Importance of Weak and Strong Ties on Social Networking Sites

Directory of Open Access Journals (Sweden)

Nicole C. Krämer

2014-12-01

Full Text Available Theoretical approaches as well as empirical results in the area of social capital accumulation on social networking sites suggest that weak ties/bridging versus strong ties/bonding social capital should be distinguished and that while bonding social capital is connected to emotional support, bridging social capital entails the provision of information. Additionally, recent studies imply the notion that weak ties/bridging social capital are gaining increasing importance in today’s social media environments. By means of a survey (N = 317 we challenged these presuppositions by assessing the social support functions that are ascribed to three different types of contacts from participants’ network (weak, medium, or strong tie. In contrast to theoretical assumptions, we do not find that weak ties are experienced to supply informational support whereas strong ties first and foremost provide emotional support. Instead we find that within social networking sites, strong ties are perceived to provide both emotional and informational support and weak ties are perceived as less important than recent literature assumes.

Statistical Analysis of Data for Timber Strengths

DEFF Research Database (Denmark)

Sørensen, John Dalsgaard

2003-01-01

Statistical analyses are performed for material strength parameters from a large number of specimens of structural timber. Non-parametric statistical analysis and fits have been investigated for the following distribution types: Normal, Lognormal, 2 parameter Weibull and 3-parameter Weibull...... fits to the data available, especially if tail fits are used whereas the Log Normal distribution generally gives a poor fit and larger coefficients of variation, especially if tail fits are used. The implications on the reliability level of typical structural elements and on partial safety factors...... for timber are investigated....

High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo.

Directory of Open Access Journals (Sweden)

Li Zhi

Full Text Available Clinical studies have shown hyperuricemia strongly associated with insulin resistance as well as cardiovascular disease. Direct evidence of how high uric acid (HUA affects insulin resistance in cardiomyocytes, but the pathological mechanism of HUA associated with cardiovascular disease remains to be clarified. We aimed to examine the effect of HUA on insulin sensitivity in cardiomyocytes and on insulin resistance in hyperuricemic mouse model. We exposed primary cardiomyocytes and a rat cardiomyocyte cell line, H9c2 cardiomyocytes, to HUA, then quantified glucose uptake with a fluorescent glucose analog, 2-NBDG, after insulin challenge and detected reactive oxygen species (ROS production. Western blot analysis was used to examine the levels of insulin receptor (IR, phosphorylated insulin receptor substrate 1 (IRS1, Ser307 and phospho-Akt (Ser473. We monitored the impact of HUA on insulin resistance, insulin signaling and IR, phospho-IRS1 (Ser307 and phospho-Akt levels in myocardial tissue of an acute hyperuricemia mouse model established by potassium oxonate treatment. HUA inhibited insulin-induced glucose uptake in H9c2 and primary cardiomyocytes. It increased ROS production; pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger, reversed HUA-inhibited glucose uptake induced by insulin. HUA exposure directly increased the phospho-IRS1 (Ser307 response to insulin and inhibited that of phospho-Akt in H9C2 cardiomyocytes, which was blocked by NAC. Furthermore, the acute hyperuricemic mice model showed impaired glucose tolerance and insulin tolerance accompanied by increased phospho-IRS1 (Ser307 and inhibited phospho-Akt response to insulin in myocardial tissues. HUA inhibited insulin signaling and induced insulin resistance in cardiomyocytes in vitro and in vivo, which is a novel potential mechanism of hyperuricemic-related cardiovascular disease.

Atherogenic Index of Plasma Predicts Hyperuricemia in Rural Population: A Cross-Sectional Study from Northeast China.

Science.gov (United States)

Chang, Ye; Li, Yuan; Guo, Xiaofan; Guo, Liang; Sun, Yingxian

2016-09-02

We aimed to determine the association of atherogenic index of plasma (AIP) with hyperuricemia (HUA) in the rural population of northeast China. This cross-sectional study was conducted in the rural areas of northeast China from January 2012 to August 2013, and the final analysis included data obtained form 5253 men and 6092 women. 1104 participants (9.7%) suffered from HUA. Spearman rank test showed that AIP was positively correlated with uric acid in both sexes (r = 0.310 for men and r = 0.347 for women, both p 0.21) risk. The prevalence of HUA increased with AIP. Multivariate logistic regression analysis showed that, compared to the low AIP group, participants in increased AIP group had a 2.536-fold risk for HUA (2.164-fold in male and 2.960-fold in female) after adjustment for covariates. Results of receiver operating characteristic curves showed that the area under the curve (95% confidence intervals) was 0.686 (0.665-0.707) for male and 0.730 (0.706-0.755) for female. We indicated that increased AIP was associated with higher serum uric acid levels and could be identified as an independent risk factor of HUA in the rural population of northeast China.

Numeric computation and statistical data analysis on the Java platform

CERN Document Server

Chekanov, Sergei V

2016-01-01

Numerical computation, knowledge discovery and statistical data analysis integrated with powerful 2D and 3D graphics for visualization are the key topics of this book. The Python code examples powered by the Java platform can easily be transformed to other programming languages, such as Java, Groovy, Ruby and BeanShell. This book equips the reader with a computational platform which, unlike other statistical programs, is not limited by a single programming language. The author focuses on practical programming aspects and covers a broad range of topics, from basic introduction to the Python language on the Java platform (Jython), to descriptive statistics, symbolic calculations, neural networks, non-linear regression analysis and many other data-mining topics. He discusses how to find regularities in real-world data, how to classify data, and how to process data for knowledge discoveries. The code snippets are so short that they easily fit into single pages. Numeric Computation and Statistical Data Analysis ...

Cracking and impact performance characteristics of plastic composite ties.

Science.gov (United States)

2012-03-01

As followup to a workshop on Engineered Composite Ties sponsored by the American Railway Engineering and Maintenance-of-Way Association and the Federal Railroad Administration, the Transportation Technology Center, Inc., in Pueblo, CO, conducted a se...

Peru turnaround tied to privatization

International Nuclear Information System (INIS)

Anon.

1993-01-01

Petroleos del Peru predicts a 10% increase in Peru's oil production this year and a further increase in 1994. Petroperu also forecasts a sharp increase in drilling in Peru this year. After several years of declining oil production, a gradual turnaround in the cash strapped country's petroleum industry is largely tied to its progress in privatization. The government last year began a campaign to privatize all state owned companies by the end of July 1995. The paper discusses forecasts by Petroperu; the contract of Occidental del Amazonas Inc.; the Petromar privatization; Great Western's contract; development of the Aguaytia gas field; and refinery contracts

Polycyclic aromatic hydrocarbon migration from creosote-treated railway ties into ballast and adjacent wetlands

Science.gov (United States)

Kenneth M. Brooks

2004-01-01

Occasionally, creosote-treated railroad ties need to be replaced, sometimes in sensitive environments such as wetlands. To help determine if this is detrimental to the surrounding environment, more information is needed on the extent and pattern of creosote, or more specifically polycyclic aromatic hydrocarbon (PAH), migration from railroad ties and what effects this...

Fine structures of the ejaculatory sac and sperm pump of the scorpionfly Panorpa liui Hua (Mecoptera: Panorpidae).

Science.gov (United States)

Shen, Jian; Hua, Baozhen

2013-08-01

Male adults of Panorpidae possess a special sperm pump, through which the males transfer liquid sperm to the females. However, the structures of the sperm pump and the transfer mechanism have not been satisfactorily elucidated hitherto. In this paper the structures of the ejaculatory sac and sperm pump of the scorpionfly Panorpa liui Hua were investigated using light microscopy and scanning electron microscopy. The ejaculatory sac is located between the basal end of the paired vasa deferentia and the aedeagus, comprising a small anterior part and a large posterior part. The anterior part is simple and functions only as a channel for sperm transfer. The epithelial cells of the large posterior part likely have secretory functions. The sperm pump is formed by the posterior region of the ejaculatory sac and derivates of the genital field, which enclose the pumping chamber, a piston and the associated muscles. The orifice of the ejaculatory duct lies ventrad of the piston. The piston of the sperm pump is heavily sclerotized and controlled by two antagonistic muscle pairs. A pair of simple tubular accessory glands opens to the pumping chamber. Two well-developed sex pheromone glands are located on the ventral side of the ejaculatory sac, and are composed of two fan-shaped lamellae. The epithelium of the sex pheromone glands is single-layered, and forms densely filamentous processes. The ejaculation mechanism is briefly discussed based on the morphology of ejaculatory sac and sperm pump. Copyright © 2013 Elsevier Ltd. All rights reserved.

A Divergence Statistics Extension to VTK for Performance Analysis

Energy Technology Data Exchange (ETDEWEB)

Pebay, Philippe Pierre [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bennett, Janine Camille [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-02-01

This report follows the series of previous documents ([PT08, BPRT09b, PT09, BPT09, PT10, PB13], where we presented the parallel descriptive, correlative, multi-correlative, principal component analysis, contingency, k -means, order and auto-correlative statistics engines which we developed within the Visualization Tool Kit ( VTK ) as a scalable, parallel and versatile statistics package. We now report on a new engine which we developed for the calculation of divergence statistics, a concept which we hereafter explain and whose main goal is to quantify the discrepancy, in a stasticial manner akin to measuring a distance, between an observed empirical distribution and a theoretical, "ideal" one. The ease of use of the new diverence statistics engine is illustrated by the means of C++ code snippets. Although this new engine does not yet have a parallel implementation, it has already been applied to HPC performance analysis, of which we provide an example.

Urban violence and displacement, gender, and community ties ...

International Development Research Centre (IDRC) Digital Library (Canada)

2017-10-20

Oct 20, 2017 ... SAIC experts explored poverty, violence, and inequality in 40 cities across Latin America, South Asia, and sub-Saharan Africa. The 15 research ... Urban violence and displacement, gender, and community ties. October 20 ... in urban spaces. Return to main page: Solutions to make cities safe and inclusive.

Developments in statistical analysis in quantitative genetics

DEFF Research Database (Denmark)

Sorensen, Daniel

2009-01-01

of genetic means and variances, models for the analysis of categorical and count data, the statistical genetics of a model postulating that environmental variance is partly under genetic control, and a short discussion of models that incorporate massive genetic marker information. We provide an overview......A remarkable research impetus has taken place in statistical genetics since the last World Conference. This has been stimulated by breakthroughs in molecular genetics, automated data-recording devices and computer-intensive statistical methods. The latter were revolutionized by the bootstrap...... and by Markov chain Monte Carlo (McMC). In this overview a number of specific areas are chosen to illustrate the enormous flexibility that McMC has provided for fitting models and exploring features of data that were previously inaccessible. The selected areas are inferences of the trajectories over time...

On the Statistical Validation of Technical Analysis

Directory of Open Access Journals (Sweden)

Rosane Riera Freire

2007-06-01

Full Text Available Technical analysis, or charting, aims on visually identifying geometrical patterns in price charts in order to antecipate price "trends". In this paper we revisit the issue of thecnical analysis validation which has been tackled in the literature without taking care for (i the presence of heterogeneity and (ii statistical dependence in the analyzed data - various agglutinated return time series from distinct financial securities. The main purpose here is to address the first cited problem by suggesting a validation methodology that also "homogenizes" the securities according to the finite dimensional probability distribution of their return series. The general steps go through the identification of the stochastic processes for the securities returns, the clustering of similar securities and, finally, the identification of presence, or absence, of informatinal content obtained from those price patterns. We illustrate the proposed methodology with a real data exercise including several securities of the global market. Our investigation shows that there is a statistically significant informational content in two out of three common patterns usually found through technical analysis, namely: triangle, rectangle and head and shoulders.

Supporting Third Year Medical Students' Skill Acquisition and Self-Efficacy with Coping Models and Process Feedback during Laparoscopic Knot Tying Simulation.

Science.gov (United States)

Dempsey, Michael S; Kauffman, Douglas F

2017-01-01

Background: During the third year general surgery clerkship, medical students are required to develop laparoscopic knot-tying skills. Knot-tying skills studies often rely on objective variables (e.g., time, materials used, number of iterations) that lend themselves to correlational analysis of pre- and post-intervention skill level. This study differs by examining how instructional interventions-role modeling and feedback-affect medical students' skill acquisition and self-efficacy during a laparoscopic surgical simulation training session. Methods: Seventy-eight surgical clerkship students were assigned randomly to one cell of a 2X2 factorial design. Participants observed one of two types of role modeling (expert vs. coping) and received either process-oriented or outcome-oriented feedback during a 30-min laparoscopic training session. Participants also completed several surveys that assessed their interest in surgery and their self-efficacy for laparoscopic knot tying. Results: Coping model groups tended to perform better on the knot tying task, though this was less the case in the presence of outcome feedback. Expert model groups slightly outperformed the coping model group on the peg transfer task, but in the presence of outcome feedback they reported the lowest satisfaction with their performance and the lowest self-efficacy for the knot tying task. The coping model combined with process feedback had a positive influence on students' efficiency in learning the task, on their satisfaction with their performance, and on their self-efficacy for laparoscopic knot typing. Conclusions: Results are discussed relative to self-regulated learning theory.

Intermediate Monocytes but Not TIE2-Expressing Monocytes Are a Sensitive Diagnostic Indicator for Colorectal Cancer

Science.gov (United States)

Schauer, Dominic; Starlinger, Patrick; Reiter, Christian; Jahn, Nikolaus; Zajc, Philipp; Buchberger, Elisabeth; Bachleitner-Hofmann, Thomas; Bergmann, Michael; Stift, Anton; Gruenberger, Thomas; Brostjan, Christine

2012-01-01

We have conducted the first study to determine the diagnostic potential of the CD14++CD16+ intermediate monocytes as compared to the pro-angiogenic subset of CD14++CD16+TIE2+ TIE2-expressing monocytes (TEMs) in cancer. These monocyte populations were investigated by flow cytometry in healthy volunteers (N = 32) and in colorectal carcinoma patients with localized (N = 24) or metastatic (N = 37) disease. We further determined blood levels of cytokines associated with monocyte regulation. The results revealed the intermediate monocyte subset to be significantly elevated in colorectal cancer patients and to show the highest frequencies in localized disease. Multivariate regression analysis identified intermediate monocytes as a significant independent variable in cancer prediction. With a cut-off value at 0.37% (intermediate monocytes of total leukocytes) the diagnostic sensitivity and specificity ranged at 69% and 81%, respectively. In contrast, TEM levels were elevated in localized cancer but did not differ significantly between groups and none of the cytokines correlated with monocyte subpopulations. Of interest, in vitro analyses supported the observation that intermediate monocytes were more potently induced by primary as opposed to metastatic cancer cells which may relate to the immunosuppressive milieu established in the advanced stage of metastatic disease. In conclusion, intermediate monocytes as compared to TIE2-expressing monocytes are a more sensitive diagnostic indicator of colorectal cancer. PMID:22973451

Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.

Directory of Open Access Journals (Sweden)

Dominic Schauer

Full Text Available We have conducted the first study to determine the diagnostic potential of the CD14++CD16+ intermediate monocytes as compared to the pro-angiogenic subset of CD14++CD16+TIE2+ TIE2-expressing monocytes (TEMs in cancer. These monocyte populations were investigated by flow cytometry in healthy volunteers (N = 32 and in colorectal carcinoma patients with localized (N = 24 or metastatic (N = 37 disease. We further determined blood levels of cytokines associated with monocyte regulation. The results revealed the intermediate monocyte subset to be significantly elevated in colorectal cancer patients and to show the highest frequencies in localized disease. Multivariate regression analysis identified intermediate monocytes as a significant independent variable in cancer prediction. With a cut-off value at 0.37% (intermediate monocytes of total leukocytes the diagnostic sensitivity and specificity ranged at 69% and 81%, respectively. In contrast, TEM levels were elevated in localized cancer but did not differ significantly between groups and none of the cytokines correlated with monocyte subpopulations. Of interest, in vitro analyses supported the observation that intermediate monocytes were more potently induced by primary as opposed to metastatic cancer cells which may relate to the immunosuppressive milieu established in the advanced stage of metastatic disease. In conclusion, intermediate monocytes as compared to TIE2-expressing monocytes are a more sensitive diagnostic indicator of colorectal cancer.

DO TIE LABORATORY BASED METHODS REALLY REFLECT FIELD CONDITIONS

Science.gov (United States)

Sediment Toxicity Identification and Evaluation (TIE) methods have been developed for both interstitial waters and whole sediments. These relatively simple laboratory methods are designed to identify specific toxicants or classes of toxicants in sediments; however, the question ...

Appplication of statistical mechanical methods to the modeling of social networks

Science.gov (United States)

Strathman, Anthony Robert

With the recent availability of large-scale social data sets, social networks have become open to quantitative analysis via the methods of statistical physics. We examine the statistical properties of a real large-scale social network, generated from cellular phone call-trace logs. We find this network, like many other social networks to be assortative (r = 0.31) and clustered (i.e., strongly transitive, C = 0.21). We measure fluctuation scaling to identify the presence of internal structure in the network and find that structural inhomogeneity effectively disappears at the scale of a few hundred nodes, though there is no sharp cutoff. We introduce an agent-based model of social behavior, designed to model the formation and dissolution of social ties. The model is a modified Metropolis algorithm containing agents operating under the basic sociological constraints of reciprocity, communication need and transitivity. The model introduces the concept of a social temperature. We go on to show that this simple model reproduces the global statistical network features (incl. assortativity, connected fraction, mean degree, clustering, and mean shortest path length) of the real network data and undergoes two phase transitions, one being from a "gas" to a "liquid" state and the second from a liquid to a glassy state as function of this social temperature.

Data management and statistical analysis for environmental assessment

International Nuclear Information System (INIS)

Wendelberger, J.R.; McVittie, T.I.

1995-01-01

Data management and statistical analysis for environmental assessment are important issues on the interface of computer science and statistics. Data collection for environmental decision making can generate large quantities of various types of data. A database/GIS system developed is described which provides efficient data storage as well as visualization tools which may be integrated into the data analysis process. FIMAD is a living database and GIS system. The system has changed and developed over time to meet the needs of the Los Alamos National Laboratory Restoration Program. The system provides a repository for data which may be accessed by different individuals for different purposes. The database structure is driven by the large amount and varied types of data required for environmental assessment. The integration of the database with the GIS system provides the foundation for powerful visualization and analysis capabilities

Single-port laparoscopic ovariectomy using a pre-tied loop ligature in Santa Ines ewes

Directory of Open Access Journals (Sweden)

Felipe Farias Pereira da Câmara Barros

2015-11-01

Full Text Available ABSTRACT: The aim of the study was to develop and assess the feasibility, postoperative pain and inflammatory response of the single-port laparoscopic ovariectomy in ewes, using a simple pre-tied loop ligature technique. Pre-tied Meltzer's knot was employed for prophylactic hemostasis of the ovarian pedicle. Slipknot was inserted within the abdominal cavity through a 14-gauge needle and tied surrounding the ovarian pedicle. Mean surgical time, manipulation, ligature and resection of each ovary and anesthesia time were 63±20, 20±10 and 91±26 minutes, respectively. No bleeding occurred during the surgeries. Ewes showed low scores pain (0.5±0.5 at all time-points. Postsurgical plasma fibrinogen was within the normal range for sheep specie at all time-points. The ewes showed a significant weight gain in comparison to the basal scaling (one day before the surgery. Single-port laparoscopic ovariectomy using a pre-tied loop ligature is feasible in the ovine specie and provided minimal postoperative distress and quick weight gain.

The blind faith deep water horizontal pipeline tie-in project

Energy Technology Data Exchange (ETDEWEB)

Charalambides, John Nicos [Oceaneering International, Inc., Houston, TX (United States)

2009-12-19

This presentation will concentrate on the design challenges, experience and learning from the SIT and offshore installation of two deepwater pipeline tie-ins using first-of-its-kind subsea technology and installation methodologies on the 'Blind Faith' project. The Blind Faith Subsea Tie-Ins join the Blind Faith oil and gas pipelines with the Canyon Chief gas pipeline and the Mountaineer oil pipeline in 5100 feet of water. Both of the Blind Faith oil and gas pipelines are terminated with conventional PLEMs providing a horizontal connector for the tie-in and a vertical connector for a future tie-in connection point. The connectors are ROV operable/installable clamp style connectors. The method of joining to the Canyon Chief oil and gas pipelines and the type of jumper employed are unique to the tie-in. An ROV operable / installable mechanical pipe end connector connects the bare ends of the Canyon Chief and Mountaineer pipelines. The mechanical pipe end connector is fitted with an integral clamp connector hub and rests on an ROV installed mud mat. After installation of the mechanical connector, metrology was performed to create a neutral state horizontal jumper for joining the mechanical connector hub and the Blind Faith PLEM. The neutral state horizontal jumper is a compliant 'Z-Bend' design. During installation the jumper was elastically pre-deformed using a bowstring system. Pre-deformation of the jumper provided installation clearances and facilitated the neutral stress state after installation. Once landed the jumper bowstring was relaxed, allowing the jumper to expand to fit between the hubs. After expansion and make-up, the clamp connectors were tightened via an ROV operated hydraulic torque wrench. A seal test verified the integrity of the connections. After installation the jumper remains in a minimal residual stress state atypical of most horizontal jumpers. The horizontal jumper was chosen over the vertical jumper because it provides a

Matrilineal Family Ties and Marital Dissolution in Ghana

Science.gov (United States)

Takyi, Baffour K.; Gyimah, Stephen Obeng

2007-01-01

Although previous work has attributed the instability of African marriages to the diffusion of Western norms and values in the region, fewer attempts have been made to empirically assess how Africa's internal institutional structures, such as extended kinship ties, impact marital outcomes. Guided by rational choice and exchange theories, we argue…

Compliance strategy for statistically based neutron overpower protection safety analysis methodology

International Nuclear Information System (INIS)

Holliday, E.; Phan, B.; Nainer, O.

2009-01-01

The methodology employed in the safety analysis of the slow Loss of Regulation (LOR) event in the OPG and Bruce Power CANDU reactors, referred to as Neutron Overpower Protection (NOP) analysis, is a statistically based methodology. Further enhancement to this methodology includes the use of Extreme Value Statistics (EVS) for the explicit treatment of aleatory and epistemic uncertainties, and probabilistic weighting of the initial core states. A key aspect of this enhanced NOP methodology is to demonstrate adherence, or compliance, with the analysis basis. This paper outlines a compliance strategy capable of accounting for the statistical nature of the enhanced NOP methodology. (author)

TH-CD-207B-05: Measurement of CT Bow-Tie Profiles Using a Linear Array Detector

Energy Technology Data Exchange (ETDEWEB)

Yang, K; Li, X; Liu, B [Massachusetts General Hospital, Boston, MA (United States)

2016-06-15

Purpose: To accurately measure CT bow-tie profiles from various manufacturers and to provide non-proprietary information for CT system modeling. Methods: A GOS-based linear detector (0.8 mm per pixel and 51.2 cm in length) with a fast data sampling speed (0.24 ms/sample) was used to measure the relative profiles of bow-tie filters from a collection of eight CT scanners by three different vendors, GE (LS Xtra, LS VCT, Discovery HD750), Siemens (Sensation 64, Edge, Flash, Force), and Philips (iBrilliance 256). The linear detector was first calibrated for its energy response within typical CT beam quality ranges and compared with an ion chamber and analytical modeling (SPECTRA and TASMIP). A geometrical calibration process was developed to determine key parameters including the distance from the focal spot to the linear detector, the angular increment of the gantry at each data sampling, the location of the central x-ray on the linear detector, and the angular response of the detector pixel. Measurements were performed under axial-scan modes for most representative bow-tie filters and kV selections from each scanner. Bow-tie profiles were determined by re-binning the measured rotational data with an angular accuracy of 0.1 degree using the calibrated geometrical parameters. Results: The linear detector demonstrated an energy response as a solid state detector, which is close to the CT imaging detector. The geometrical calibration was proven to be sufficiently accurate (< 1mm in error for distances >550 mm) and the bow-tie profiles measured from rotational mode matched closely to those from the gantry-stationary mode. Accurate profiles were determined for a total of 21 bow-tie filters and 83 filter/kV combinations from the abovementioned scanner models. Conclusion: A new improved approach of CT bow-tie measurement was proposed and accurate bow-tie profiles were provided for a broad list of CT scanner models.

Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.

Directory of Open Access Journals (Sweden)

Jessica L Reinardy

Full Text Available The endothelial receptor tyrosine kinase (RTK Tie1 was discovered over 20 years ago, yet its precise function and mode of action remain enigmatic. To shed light on Tie1's role in endothelial cell biology, we investigated a potential threonine phosphorylation site within the juxtamembrane domain of Tie1. Expression of a non-phosphorylatable mutant of this site (T794A in zebrafish (Danio rerio significantly disrupted vascular development, resulting in fish with stunted and poorly branched intersomitic vessels. Similarly, T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures. However, mutation of T794 did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling in any detectable way, suggesting that T794 phosphorylation may regulate a Tie1 function independent of its RTK properties. Although T794 is within a consensus Akt phosphorylation site, we were unable to identify a physiological activator of Akt that could induce T794 phosphorylation, suggesting that Akt is not the physiological Tie1-T794 kinase. However, the small GTPase Ras-related C3 botulinum toxin substrate 1 (Rac1, which is required for angiogenesis and capillary morphogenesis, was found to associate with phospho-T794 but not the non-phosphorylatable T794A mutant. Pharmacological activation of Rac1 induced downstream activation of p21-activated kinase (PAK1 and T794 phosphorylation in vitro, and inhibition of PAK1 abrogated T794 phosphorylation. Our results provide the first demonstration of a signaling pathway mediated by Tie1 in endothelial cells, and they suggest that a novel feedback loop involving Rac1/PAK1 mediated phosphorylation of Tie1 on T794 is required for proper angiogenesis.

Creative benefits from well-connected leaders: leader social network ties as facilitators of employee radical creativity.

Science.gov (United States)

Venkataramani, Vijaya; Richter, Andreas W; Clarke, Ronald

2014-09-01

Employee radical creativity critically depends on substantive informational resources from others across the wider organization. We propose that the social network ties of employees' immediate leaders assume a central role in garnering these resources, thereby fostering their employees' radical creativity both independent of and interactively with employees' own network ties. Drawing on data from 214 employees working in 30 teams of a public technology and environmental services organization, we find that team leaders' betweenness centrality in the idea network within their teams as well as among their peer leaders provides creative benefits beyond employees' own internal and external ties. Further, employees' and leaders' ties within and external to the team interactively predict employee radical creativity. Implications for theory and practice are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Diagnosis checking of statistical analysis in RCTs indexed in PubMed.

Science.gov (United States)

Lee, Paul H; Tse, Andy C Y

2017-11-01

Statistical analysis is essential for reporting of the results of randomized controlled trials (RCTs), as well as evaluating their effectiveness. However, the validity of a statistical analysis also depends on whether the assumptions of that analysis are valid. To review all RCTs published in journals indexed in PubMed during December 2014 to provide a complete picture of how RCTs handle assumptions of statistical analysis. We reviewed all RCTs published in December 2014 that appeared in journals indexed in PubMed using the Cochrane highly sensitive search strategy. The 2014 impact factors of the journals were used as proxies for their quality. The type of statistical analysis used and whether the assumptions of the analysis were tested were reviewed. In total, 451 papers were included. Of the 278 papers that reported a crude analysis for the primary outcomes, 31 (27·2%) reported whether the outcome was normally distributed. Of the 172 papers that reported an adjusted analysis for the primary outcomes, diagnosis checking was rarely conducted, with only 20%, 8·6% and 7% checked for generalized linear model, Cox proportional hazard model and multilevel model, respectively. Study characteristics (study type, drug trial, funding sources, journal type and endorsement of CONSORT guidelines) were not associated with the reporting of diagnosis checking. The diagnosis of statistical analyses in RCTs published in PubMed-indexed journals was usually absent. Journals should provide guidelines about the reporting of a diagnosis of assumptions. © 2017 Stichting European Society for Clinical Investigation Journal Foundation.

A κ-generalized statistical mechanics approach to income analysis

Science.gov (United States)

Clementi, F.; Gallegati, M.; Kaniadakis, G.

2009-02-01

This paper proposes a statistical mechanics approach to the analysis of income distribution and inequality. A new distribution function, having its roots in the framework of κ-generalized statistics, is derived that is particularly suitable for describing the whole spectrum of incomes, from the low-middle income region up to the high income Pareto power-law regime. Analytical expressions for the shape, moments and some other basic statistical properties are given. Furthermore, several well-known econometric tools for measuring inequality, which all exist in a closed form, are considered. A method for parameter estimation is also discussed. The model is shown to fit remarkably well the data on personal income for the United States, and the analysis of inequality performed in terms of its parameters is revealed as very powerful.

A κ-generalized statistical mechanics approach to income analysis

International Nuclear Information System (INIS)

Clementi, F; Gallegati, M; Kaniadakis, G

2009-01-01

This paper proposes a statistical mechanics approach to the analysis of income distribution and inequality. A new distribution function, having its roots in the framework of κ-generalized statistics, is derived that is particularly suitable for describing the whole spectrum of incomes, from the low–middle income region up to the high income Pareto power-law regime. Analytical expressions for the shape, moments and some other basic statistical properties are given. Furthermore, several well-known econometric tools for measuring inequality, which all exist in a closed form, are considered. A method for parameter estimation is also discussed. The model is shown to fit remarkably well the data on personal income for the United States, and the analysis of inequality performed in terms of its parameters is revealed as very powerful

Normality Tests for Statistical Analysis: A Guide for Non-Statisticians

Science.gov (United States)

Ghasemi, Asghar; Zahediasl, Saleh

2012-01-01

Statistical errors are common in scientific literature and about 50% of the published articles have at least one error. The assumption of normality needs to be checked for many statistical procedures, namely parametric tests, because their validity depends on it. The aim of this commentary is to overview checking for normality in statistical analysis using SPSS. PMID:23843808

The Missing Link: the Role of Floodplain Tie Channels in Connecting Off River Water Bodies to Lowland Rivers

Science.gov (United States)

Rowland, J. C.; Dietrich, W. E.; Day, G.

2005-05-01

Along lowland river systems across the globe the exchange of water, sediment, carbon, nutrients and biota between main stem rivers and off-river water bodies (ORWB) is facilitated by the presence of stable secondary channels referred to here as tie channels. Sixty five percent of the ORWB along the middle Fly River in Papua New Guinea connect to the river through such channels. A similar percentage of the 37 ORWB located between Baton Rouge and Memphis on the lower Mississippi River at one time were linked to the river by tie or batture (as they are locally known) channels. Levee construction and other alterations aimed at flood control or navigation on the Mississippi have left only a handful of lakes connected to the river, of these, most are heavily altered by dredging or other modifications. Tie channels were also once common along major tributaries to the Mississippi, such as the Red River. In the much less disturbed Alaskan environment, tie channels are still common, especially along Birch Creek and the Koyukuk and Black rivers. Our studies on the Mississippi River, in Alaska and in Papua New Guinea indicate that tie channels possess a common channel form that is stable and self-maintaining for hundreds to possibly a thousand years. Tie channels exhibit narrow width to depth ratios (~ 5.5) and consistently scale in cross-sectional dimensions to the size of the lake into which they flow. Variations in river and lake stage drive flow bi-directionally through tie channels. A local high or sill in the bed of tie channels controls the degree and duration of connection between the river and ORWB, with many lakes becoming isolated during periods of low stage. The life-span of a tie channel depends on the rate of sediment loading to the ORWB. Our research indicates that this rate directly corresponds to the sediment loading in the main stem river. Along the Fly River, for example, a 5 to 7 fold increase in the river sediment load has resulted increases of 6 to 17

The bright-side and dark-side effects of embedded ties in business-to-business innovation

NARCIS (Netherlands)

Noordhoff, C.S.; Kyriakopoulos, K.; Moorman, C.; Pauwels, P.; Dellaert, B.

2011-01-01

Although the number and importance of joint innovation projects between suppliers and their customers continue to rise, the literature has yet to resolve a key question: Do embedded ties with customers help or hurt supplier innovation? Drawing on both the tie strength and knowledge literatures, the

TIE - DYE (ADIRE) AMONG THE JUKUN PEOPLE Gausa Solomon ...

African Journals Online (AJOL)

SO

clothing scraps or fibrous materials from municipal waste stream (Wikipedia, 2014). ... example fabric that has been tie-dyed can be recycled and used as lamp shades, .... Dye colour is used in the manufacture of plastic products, but their most ...

Children's Books in Review: Books on Strengthening Family Ties.

Science.gov (United States)

Winfield, Evelyn T.

1991-01-01

Reviews children's books that emphasize the strengthening of family ties. Characters in the books realize the importance and influence of family relationships as they struggle with sibling rivalry, self-discovery, peer relationships, a search for heritage, adoption, and death. (SM)

Development of computer-assisted instruction application for statistical data analysis android platform as learning resource

Science.gov (United States)

Hendikawati, P.; Arifudin, R.; Zahid, M. Z.

2018-03-01

This study aims to design an android Statistics Data Analysis application that can be accessed through mobile devices to making it easier for users to access. The Statistics Data Analysis application includes various topics of basic statistical along with a parametric statistics data analysis application. The output of this application system is parametric statistics data analysis that can be used for students, lecturers, and users who need the results of statistical calculations quickly and easily understood. Android application development is created using Java programming language. The server programming language uses PHP with the Code Igniter framework, and the database used MySQL. The system development methodology used is the Waterfall methodology with the stages of analysis, design, coding, testing, and implementation and system maintenance. This statistical data analysis application is expected to support statistical lecturing activities and make students easier to understand the statistical analysis of mobile devices.

Measurement of the location of tie-bar shoulders

CERN Multimedia

Hubert Gerwig

2001-01-01

The inner vactank is machined on a length of 13m at the location of the rails for HCAL. in addition at one side the inner vactank has shoulders to lodge the M48 tie-bars that will guarantee the fixation to the swivelling platform actually produced at HANJUNG Company in South Korea

Bi-directional evolutionary structural optimization for strut-and-tie modelling of three-dimensional structural concrete

Science.gov (United States)

Shobeiri, Vahid; Ahmadi-Nedushan, Behrouz

2017-12-01

This article presents a method for the automatic generation of optimal strut-and-tie models in reinforced concrete structures using a bi-directional evolutionary structural optimization method. The methodology presented is developed for compliance minimization relying on the Abaqus finite element software package. The proposed approach deals with the generation of truss-like designs in a three-dimensional environment, addressing the design of corbels and joints as well as bridge piers and pile caps. Several three-dimensional examples are provided to show the capabilities of the proposed framework in finding optimal strut-and-tie models in reinforced concrete structures and verifying its efficiency to cope with torsional actions. Several issues relating to the use of the topology optimization for strut-and-tie modelling of structural concrete, such as chequerboard patterns, mesh-dependency and multiple load cases, are studied. In the last example, a design procedure for detailing and dimensioning of the strut-and-tie models is given according to the American Concrete Institute (ACI) 318-08 provisions.

Statistical analysis of metallicity in spiral galaxies

Energy Technology Data Exchange (ETDEWEB)

Galeotti, P [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Turin Univ. (Italy). Ist. di Fisica Generale)

1981-04-01

A principal component analysis of metallicity and other integral properties of 33 spiral galaxies is presented; the involved parameters are: morphological type, diameter, luminosity and metallicity. From the statistical analysis it is concluded that the sample has only two significant dimensions and additonal tests, involving different parameters, show similar results. Thus it seems that only type and luminosity are independent variables, being the other integral properties of spiral galaxies correlated with them.

Division of tongue tie: review of practice through a tertiary paediatric otorhinolaryngology service.

LENUS (Irish Health Repository)

Glynn, R W

2012-10-01

Recent NICE guidance declared that evidence regarding surgical division of tongue tie was adequate to support the use of the procedure, provided that normal arrangements are in place for consent, audit and clinical governance. This work aimed to carry out a retrospective review of those patients who have previously undergone tongue tie division through a tertiary paediatric otorhinolaryngology service. We further aimed to identify the referral patterns, indications for, and outcomes following, division.

Statistical Analysis of Protein Ensembles

Science.gov (United States)

Máté, Gabriell; Heermann, Dieter

2014-04-01

As 3D protein-configuration data is piling up, there is an ever-increasing need for well-defined, mathematically rigorous analysis approaches, especially that the vast majority of the currently available methods rely heavily on heuristics. We propose an analysis framework which stems from topology, the field of mathematics which studies properties preserved under continuous deformations. First, we calculate a barcode representation of the molecules employing computational topology algorithms. Bars in this barcode represent different topological features. Molecules are compared through their barcodes by statistically determining the difference in the set of their topological features. As a proof-of-principle application, we analyze a dataset compiled of ensembles of different proteins, obtained from the Ensemble Protein Database. We demonstrate that our approach correctly detects the different protein groupings.

State analysis of BOP using statistical and heuristic methods

International Nuclear Information System (INIS)

Heo, Gyun Young; Chang, Soon Heung

2003-01-01

Under the deregulation environment, the performance enhancement of BOP in nuclear power plants is being highlighted. To analyze performance level of BOP, we use the performance test procedures provided from an authorized institution such as ASME. However, through plant investigation, it was proved that the requirements of the performance test procedures about the reliability and quantity of sensors was difficult to be satisfied. As a solution of this, state analysis method that are the expanded concept of signal validation, was proposed on the basis of the statistical and heuristic approaches. Authors recommended the statistical linear regression model by analyzing correlation among BOP parameters as a reference state analysis method. Its advantage is that its derivation is not heuristic, it is possible to calculate model uncertainty, and it is easy to apply to an actual plant. The error of the statistical linear regression model is below 3% under normal as well as abnormal system states. Additionally a neural network model was recommended since the statistical model is impossible to apply to the validation of all of the sensors and is sensitive to the outlier that is the signal located out of a statistical distribution. Because there are a lot of sensors need to be validated in BOP, wavelet analysis (WA) were applied as a pre-processor for the reduction of input dimension and for the enhancement of training accuracy. The outlier localization capability of WA enhanced the robustness of the neural network. The trained neural network restored the degraded signals to the values within ±3% of the true signals

Precision Statistical Analysis of Images Based on Brightness Distribution

Directory of Open Access Journals (Sweden)

Muzhir Shaban Al-Ani

2017-07-01

Full Text Available Study the content of images is considered an important topic in which reasonable and accurate analysis of images are generated. Recently image analysis becomes a vital field because of huge number of images transferred via transmission media in our daily life. These crowded media with images lead to highlight in research area of image analysis. In this paper, the implemented system is passed into many steps to perform the statistical measures of standard deviation and mean values of both color and grey images. Whereas the last step of the proposed method concerns to compare the obtained results in different cases of the test phase. In this paper, the statistical parameters are implemented to characterize the content of an image and its texture. Standard deviation, mean and correlation values are used to study the intensity distribution of the tested images. Reasonable results are obtained for both standard deviation and mean value via the implementation of the system. The major issue addressed in the work is concentrated on brightness distribution via statistical measures applying different types of lighting.

Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter.

Science.gov (United States)

Yang, Ming-Li; Lu, Bo

2018-04-01

The present work aimed to further explore the therapeutic potential of Xing Qi Hua Ying Tang (XQHYT) by conducting a systemic clinical study in patients with goiter. Seventy-two patients with either multinodular or diffuse goiter were enrolled and randomly assigned into treatment group receiving XQHYT (n = 36) and control group receiving Hai Zao Yu Hu Tang (n = 36). Traditional Chinese Medicine Hospital of Shanxi. Patients were diagnosed multinodular goiter or diffuse goiter resulting from Qi stagnation. All patients took the extract twice a day (100 mL each time) for two courses of treatment, of which a single course lasted for 3 months. Before the treatment was commenced and after the completion of the treatment, general body checks, thyroid function test, and goiter size examination were performed. Scoring of the clinical symptoms using Chinese medicine symptomatology was also done. The symptom score of the treatment group was significantly lower than that of the control group (treatment group, 8.26 ± 2.62; control group, 10.02 ± 2.62; p < 0.05). Substantial reduction in goiter size was seen in 82.3% of XQHYT-treated patients, whereas in the control group only 67.7% of patients exhibited constricted goiter. When assessed by both the Chinese medicine criteria and goiter size, the overall effective rate of the treatment group was 91.2%, whereas that of the control group was only 67.7%. The difference was statistically significant (p < 0.05). XQHYT did not affect the normal functions of liver, kidney, and heart. For both groups of patients, their levels of thyroid-stimulating hormone, free T4 and free T3 were normal before the treatment, and were not affected by the treatment. XQHYT was shown to be a promising therapeutic regimen for the treatment of goiter. The herbal regimen ameliorated clinical symptoms of patients that were accompanied with reduction in the size of goiter.

Fisher statistics for analysis of diffusion tensor directional information.

Science.gov (United States)

Hutchinson, Elizabeth B; Rutecki, Paul A; Alexander, Andrew L; Sutula, Thomas P

2012-04-30

A statistical approach is presented for the quantitative analysis of diffusion tensor imaging (DTI) directional information using Fisher statistics, which were originally developed for the analysis of vectors in the field of paleomagnetism. In this framework, descriptive and inferential statistics have been formulated based on the Fisher probability density function, a spherical analogue of the normal distribution. The Fisher approach was evaluated for investigation of rat brain DTI maps to characterize tissue orientation in the corpus callosum, fornix, and hilus of the dorsal hippocampal dentate gyrus, and to compare directional properties in these regions following status epilepticus (SE) or traumatic brain injury (TBI) with values in healthy brains. Direction vectors were determined for each region of interest (ROI) for each brain sample and Fisher statistics were applied to calculate the mean direction vector and variance parameters in the corpus callosum, fornix, and dentate gyrus of normal rats and rats that experienced TBI or SE. Hypothesis testing was performed by calculation of Watson's F-statistic and associated p-value giving the likelihood that grouped observations were from the same directional distribution. In the fornix and midline corpus callosum, no directional differences were detected between groups, however in the hilus, significant (pstatistical comparison of tissue structural orientation. Copyright © 2012 Elsevier B.V. All rights reserved.

Statistical analysis of RHIC beam position monitors performance

Science.gov (United States)

Calaga, R.; Tomás, R.

2004-04-01

A detailed statistical analysis of beam position monitors (BPM) performance at RHIC is a critical factor in improving regular operations and future runs. Robust identification of malfunctioning BPMs plays an important role in any orbit or turn-by-turn analysis. Singular value decomposition and Fourier transform methods, which have evolved as powerful numerical techniques in signal processing, will aid in such identification from BPM data. This is the first attempt at RHIC to use a large set of data to statistically enhance the capability of these two techniques and determine BPM performance. A comparison from run 2003 data shows striking agreement between the two methods and hence can be used to improve BPM functioning at RHIC and possibly other accelerators.

Statistical analysis of RHIC beam position monitors performance

Directory of Open Access Journals (Sweden)

R. Calaga

2004-04-01

Full Text Available A detailed statistical analysis of beam position monitors (BPM performance at RHIC is a critical factor in improving regular operations and future runs. Robust identification of malfunctioning BPMs plays an important role in any orbit or turn-by-turn analysis. Singular value decomposition and Fourier transform methods, which have evolved as powerful numerical techniques in signal processing, will aid in such identification from BPM data. This is the first attempt at RHIC to use a large set of data to statistically enhance the capability of these two techniques and determine BPM performance. A comparison from run 2003 data shows striking agreement between the two methods and hence can be used to improve BPM functioning at RHIC and possibly other accelerators.

Personal Ties in the Writing of a Doctoral Dissertation

Directory of Open Access Journals (Sweden)

Laura Colombo

2014-07-01

Full Text Available The problem of low graduation rates at the graduate level has been linked to the challenges of dissertation work. Given that this is a process of “disciplinary enculturation”, where graduate students acquire the ways of being and doing of each discipline, the social relations of doctoral candidates should be analyzed. Several studies have explored the support provided by social ties within academia but have, nevertheless, ignored other spheres. This qualitative study, based on in-depth interviews, explores the personal-sphere social relations in the dissertation writing process from the point of view of doctoral candidates and recent graduates in the fields of Education and Linguistics. Results indicate that the emotional, financial, economic, and academic support offered by these social ties is a necessary, although not in itself, sufficient condition. Some strategies for increasing institutional support to facilitate the process of writing a dissertation are offered.

Statistics Education Research in Malaysia and the Philippines: A Comparative Analysis

Science.gov (United States)

Reston, Enriqueta; Krishnan, Saras; Idris, Noraini

2014-01-01

This paper presents a comparative analysis of statistics education research in Malaysia and the Philippines by modes of dissemination, research areas, and trends. An electronic search for published research papers in the area of statistics education from 2000-2012 yielded 20 for Malaysia and 19 for the Philippines. Analysis of these papers showed…

Statistical analysis of next generation sequencing data

CERN Document Server

Nettleton, Dan

2014-01-01

Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

Selected papers on analysis, probability, and statistics

CERN Document Server

Nomizu, Katsumi

1994-01-01

This book presents papers that originally appeared in the Japanese journal Sugaku. The papers fall into the general area of mathematical analysis as it pertains to probability and statistics, dynamical systems, differential equations and analytic function theory. Among the topics discussed are: stochastic differential equations, spectra of the Laplacian and Schrödinger operators, nonlinear partial differential equations which generate dissipative dynamical systems, fractal analysis on self-similar sets and the global structure of analytic functions.

Analysis of statistical misconception in terms of statistical reasoning

Science.gov (United States)

Maryati, I.; Priatna, N.

2018-05-01

Reasoning skill is needed for everyone to face globalization era, because every person have to be able to manage and use information from all over the world which can be obtained easily. Statistical reasoning skill is the ability to collect, group, process, interpret, and draw conclusion of information. Developing this skill can be done through various levels of education. However, the skill is low because many people assume that statistics is just the ability to count and using formulas and so do students. Students still have negative attitude toward course which is related to research. The purpose of this research is analyzing students’ misconception in descriptive statistic course toward the statistical reasoning skill. The observation was done by analyzing the misconception test result and statistical reasoning skill test; observing the students’ misconception effect toward statistical reasoning skill. The sample of this research was 32 students of math education department who had taken descriptive statistic course. The mean value of misconception test was 49,7 and standard deviation was 10,6 whereas the mean value of statistical reasoning skill test was 51,8 and standard deviation was 8,5. If the minimal value is 65 to state the standard achievement of a course competence, students’ mean value is lower than the standard competence. The result of students’ misconception study emphasized on which sub discussion that should be considered. Based on the assessment result, it was found that students’ misconception happen on this: 1) writing mathematical sentence and symbol well, 2) understanding basic definitions, 3) determining concept that will be used in solving problem. In statistical reasoning skill, the assessment was done to measure reasoning from: 1) data, 2) representation, 3) statistic format, 4) probability, 5) sample, and 6) association.

Comparative analysis of positive and negative attitudes toward statistics

Science.gov (United States)

Ghulami, Hassan Rahnaward; Ab Hamid, Mohd Rashid; Zakaria, Roslinazairimah

2015-02-01

Many statistics lecturers and statistics education researchers are interested to know the perception of their students' attitudes toward statistics during the statistics course. In statistics course, positive attitude toward statistics is a vital because it will be encourage students to get interested in the statistics course and in order to master the core content of the subject matters under study. Although, students who have negative attitudes toward statistics they will feel depressed especially in the given group assignment, at risk for failure, are often highly emotional, and could not move forward. Therefore, this study investigates the students' attitude towards learning statistics. Six latent constructs have been the measurement of students' attitudes toward learning statistic such as affect, cognitive competence, value, difficulty, interest, and effort. The questionnaire was adopted and adapted from the reliable and validate instrument of Survey of Attitudes towards Statistics (SATS). This study is conducted among engineering undergraduate engineering students in the university Malaysia Pahang (UMP). The respondents consist of students who were taking the applied statistics course from different faculties. From the analysis, it is found that the questionnaire is acceptable and the relationships among the constructs has been proposed and investigated. In this case, students show full effort to master the statistics course, feel statistics course enjoyable, have confidence that they have intellectual capacity, and they have more positive attitudes then negative attitudes towards statistics learning. In conclusion in terms of affect, cognitive competence, value, interest and effort construct the positive attitude towards statistics was mostly exhibited. While negative attitudes mostly exhibited by difficulty construct.

The value of the absent bow tie sign in MRI of bucket-handle tears

International Nuclear Information System (INIS)

Watt, Andrew J.B.; Halliday, Tonya; Raby, Nigel

2000-01-01

AIM: To assess the accuracy of the absent bow tie sign in diagnosing bucket handle meniscal tears (BHT) of the knee menisci. MATERIALS AND METHODS: During a 3-year period, we correlated the MRI and arthroscopic findings and the presence of the various signs. One hundred and seven knees were reviewed: 74 where either MRI or arthroscopy had identified a BHT and 33 which were either normal (31), or a simple tear was identified (2). All cases were reviewed by a single radiologist with a musculoskeletal interest blinded to the original results. Each was assessed for the presence of (1) a central meniscal fragment, (2) the double posterior cruciate ligament (PCL) sign, (3) the bow tie sign and (4) the contribution of a 3D-volume sequence. RESULTS: Optimal results were obtained using standard sequences and a 3D-volume sequence, giving a sensitivity of 74% and positive predictive value of 89%. The bow tie sign gave a sensitivity of 71% and positive predictive value of 76%, significantly less than previous reports. The 18 BHTs diagnosed by arthroscopy but missed by MRI showed other abnormal findings at MRI and were not reported as normal. CONCLUSION: We were not able to reproduce the previously reported high sensitivity and specificity of the absent bow tie sign. Despite optimization of all factors, the accurate diagnosis of a bucket handle tear remains difficult, and is most reliably made by identifying a central meniscal fragment, rather than relying on secondary signs such as the absent bow tie sign. Watt, A.J.B. (2000)

Vapor Pressure Data Analysis and Statistics

Science.gov (United States)

2016-12-01

near 8, 2000, and 200, respectively. The A (or a) value is directly related to vapor pressure and will be greater for high vapor pressure materials...1, (10) where n is the number of data points, Yi is the natural logarithm of the i th experimental vapor pressure value, and Xi is the...VAPOR PRESSURE DATA ANALYSIS AND STATISTICS ECBC-TR-1422 Ann Brozena RESEARCH AND TECHNOLOGY DIRECTORATE

Statistical analysis of planktic foraminifera of the surface Continental ...

African Journals Online (AJOL)

Planktic foraminiferal assemblage recorded from selected samples obtained from shallow continental shelf sediments off southwestern Nigeria were subjected to statistical analysis. The Principal Component Analysis (PCA) was used to determine variants of planktic parameters. Values obtained for these parameters were ...

Atherogenic Index of Plasma Predicts Hyperuricemia in Rural Population: A Cross-Sectional Study from Northeast China

Directory of Open Access Journals (Sweden)

Ye Chang

2016-09-01

Full Text Available We aimed to determine the association of atherogenic index of plasma (AIP with hyperuricemia (HUA in the rural population of northeast China. This cross-sectional study was conducted in the rural areas of northeast China from January 2012 to August 2013, and the final analysis included data obtained form 5253 men and 6092 women. 1104 participants (9.7% suffered from HUA. Spearman rank test showed that AIP was positively correlated with uric acid in both sexes (r = 0.310 for men and r = 0.347 for women, both p < 0.001. AIP was classified into three groups: the low (<0.11, the intermediate (0.11–0.21 and the increased (>0.21 risk. The prevalence of HUA increased with AIP. Multivariate logistic regression analysis showed that, compared to the low AIP group, participants in increased AIP group had a 2.536-fold risk for HUA (2.164-fold in male and 2.960-fold in female after adjustment for covariates. Results of receiver operating characteristic curves showed that the area under the curve (95% confidence intervals was 0.686 (0.665–0.707 for male and 0.730 (0.706–0.755 for female. We indicated that increased AIP was associated with higher serum uric acid levels and could be identified as an independent risk factor of HUA in the rural population of northeast China.

Imaging mass spectrometry statistical analysis.

Science.gov (United States)

Jones, Emrys A; Deininger, Sören-Oliver; Hogendoorn, Pancras C W; Deelder, André M; McDonnell, Liam A

2012-08-30

Imaging mass spectrometry is increasingly used to identify new candidate biomarkers. This clinical application of imaging mass spectrometry is highly multidisciplinary: expertise in mass spectrometry is necessary to acquire high quality data, histology is required to accurately label the origin of each pixel's mass spectrum, disease biology is necessary to understand the potential meaning of the imaging mass spectrometry results, and statistics to assess the confidence of any findings. Imaging mass spectrometry data analysis is further complicated because of the unique nature of the data (within the mass spectrometry field); several of the assumptions implicit in the analysis of LC-MS/profiling datasets are not applicable to imaging. The very large size of imaging datasets and the reporting of many data analysis routines, combined with inadequate training and accessible reviews, have exacerbated this problem. In this paper we provide an accessible review of the nature of imaging data and the different strategies by which the data may be analyzed. Particular attention is paid to the assumptions of the data analysis routines to ensure that the reader is apprised of their correct usage in imaging mass spectrometry research. Copyright © 2012 Elsevier B.V. All rights reserved.

Tissue reactions induced by nylon cable tie used to clamp ovarian pedicles

Directory of Open Access Journals (Sweden)

Luiz Fernando Moraes Moreira

2018-03-01

Full Text Available The aim of this study was to evaluate the tissue reactions induced by nylon cable tie by using macroscopic and histological evaluations. Forty-five clinically healthy crossbreed female dogs, 31.11 ± 14.26 months old and with a body weight of 11.26 ± 4.7 kg, underwent ovariohysterectomy using a minimally invasive procedure. The dogs were randomly divided into three groups of 15 animals each and were evaluated preoperatively, and at 30 (G1, 60 (G2 and 90 days (G3 after surgery. The histological examination of the pedicles containing the nylon cable ties, collected from five animals in each group, showed a chronic inflammatory reaction with the presence of macrophages, giant cells and fibroplasia on the 30th postoperative day. Well-organized connective tissue and presence of lymphocytes and polymorphonuclear leukocytes were seen on the 60th postoperative day, and mature connective tissue and presence of macrophages and lymphocytes were seen at 90 days. Nylon cable ties induce an inflammatory reaction, which should be considered due to the risk of interference with surrounding structures.

Mobile phones, social ties, and collective action mobilization in China

DEFF Research Database (Denmark)

Liu, Jun

2017-01-01

To provide a better understanding of mobile phones as a recruitment tool in collective actions, this study explores the use of mobile phones for mobilizing protest in China. Using in-depth interviews and investigating four cases in which Chinese people employed mobile devices to recruit...... participants for protests, this study observes that mobile communication in China embodies guanxi, the indigenous social tie in Chinese society that introduces reciprocity as an influential facilitator of collective actions. The embedment of reciprocity facilitates the proliferation of mobilizing calls......, legitimizes mobilizing appeals, generates obligations and consolidates solidarity for collective actions. The study concludes with a consideration of the relevance of mobile phones for the embedment of reciprocity in social ties in the mobilization of collective action in authoritarian regimes such as China....

China, Argentina agree to further strategic ties

Institute of Scientific and Technical Information of China (English)

2011-01-01

According to Xinhua,China and Argentina have agreed to further enhance mutual trust and their strategic partnership as the two emerging economies are playing an increasingly important role in the world arena.“China will work with Argentina to strengthen strategic mutual trust,expand cooperation and coordination within multilateral frameworks in order to promote bilateral ties and benefit the two peoples,” Vice President Xi Jinping told Argentine Foreign Minister Hector Timerman on September 9.

Applied Behavior Analysis and Statistical Process Control?

Science.gov (United States)

Hopkins, B. L.

1995-01-01

Incorporating statistical process control (SPC) methods into applied behavior analysis is discussed. It is claimed that SPC methods would likely reduce applied behavior analysts' intimate contacts with problems and would likely yield poor treatment and research decisions. Cases and data presented by Pfadt and Wheeler (1995) are cited as examples.…

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

Science.gov (United States)

García, Samuel; Krausz, Sarah; Ambarus, Carmen A; Fernández, Beatriz Malvar; Hartkamp, Linda M; van Es, Inge E; Hamann, Jörg; Baeten, Dominique L; Tak, Paul P; Reedquist, Kris A

2014-01-01

Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair. Tie2 signaling is best characterized in endothelial cells, but a subset of human and murine circulating monocytes/macrophages essential to solid tumor formation express Tie2 and display immunosuppressive properties consistent with M2 macrophage polarization. However, we have recently shown that Tie2 is strongly activated in pro-inflammatory macrophages present in rheumatoid arthritis patient synovial tissue. Here we examined the relationship between Tie2 expression and function during human macrophage polarization. Tie2 expression was observed under all polarization conditions, but was highest in IFN-γ and IL-10 -differentiated macrophages. While TNF enhanced expression of a common restricted set of genes involved in angiogenesis and inflammation in GM-CSF, IFN-γ and IL-10 -differentiated macrophages, expression of multiple chemokines and cytokines, including CXCL3, CXCL5, CXCL8, IL6, and IL12B was further augmented in the presence of Ang-1 and Ang-2, via Tie2 activation of JAK/STAT signaling. Conditioned medium from macrophages stimulated with Ang-1 or Ang-2 in combination with TNF, sustained monocyte recruitment. Our findings suggest a general role for Tie2 in cooperatively promoting the inflammatory activation of macrophages, independently of polarization conditions.

Preventing Cauliflower Ear with a Modified Tie-Through Technique.

Science.gov (United States)

Dimeff, Robert J.; Hough, David O.

1989-01-01

Describes a quick, simple tie-through suture technique (in which a collodion packing is secured to the auricle with two buttons) for preventing cauliflower ear following external ear trauma in wrestlers and boxers. The technique ensures constant compression; multiple treatments for fluid reaccumulation are rarely necessary. (SM)

Older women play predominant role in building social ties and ...

International Development Research Centre (IDRC) Digital Library (Canada)

2016-08-03

Aug 3, 2016 ... Older women play predominant role in building social ties and preventing ... brief demonstrates their contribution to building social cohesion and driving ... From learning to policy-oriented research: Lessons from South Africa's ...

Weak Ties and Self-Regulation in Job Search: The Effects of Goal Orientation on Networking

Science.gov (United States)

Hatala, John-Paul; Yamkovenko, Bogdan

2016-01-01

The purpose of this study is to empirically investigate the relationship between the self-regulatory variable of goal orientation and the extent to which job seekers reach out to and use weak ties in their job search. Weak ties, as defined by Granovettor, are connections to densely knit networks outside the individual's direct contacts who could…

Research on the network structure of the urban economic ties in Shanghai

Directory of Open Access Journals (Sweden)

CHEN Wenyan

2015-04-01

Full Text Available Assessing the network structure of the urban economic ties (NSUET of a city can help us understand its development level.Using the gravity model,the social network analysis method and the Arcgis tool,this paper has done some researches about the NSUET in Shanghai.The research results show that the NSUET in Shanghai was improved gradually from 2000 to 2010 and is in a stable status now.In the future,the NSUET in Shanghai should be adjusted to meet the need of urban development;the more focuses should be placed on the districts with better infrastructure,while the other areas are also considered to develop the NSUET.

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer

OpenAIRE

Venneri, Mary Anna; De Palma, Michele; Ponzoni, Maurilio; Pucci, Ferdinando; Scielzo, Cristina; Zonari, Erika; Mazzieri, Roberta; Doglioni, Claudio; Naldini, Luigi

2007-01-01

Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have been implicated in tumor progression. We recently described a lineage of mouse monocytes characterized by expression of the Tie2 angiopoietin receptor and required for the vascularization and growth of several tumor models. Here, we report that TIE2 expression in human blood identifies a subset of monocytes distinct from classical inflammatory monocytes and comprised within the less abundant "resident" popul...

Statistical analysis of JET disruptions

International Nuclear Information System (INIS)

Tanga, A.; Johnson, M.F.

1991-07-01

In the operation of JET and of any tokamak many discharges are terminated by a major disruption. The disruptive termination of a discharge is usually an unwanted event which may cause damage to the structure of the vessel. In a reactor disruptions are potentially a very serious problem, hence the importance of studying them and devising methods to avoid disruptions. Statistical information has been collected about the disruptions which have occurred at JET over a long span of operations. The analysis is focused on the operational aspects of the disruptions rather than on the underlining physics. (Author)

Global TIE Observatories: Real Time Observational Astronomy Through a Robotic Telescope Network

Science.gov (United States)

Clark, G.; Mayo, L. A.

2001-12-01

activities. Hundreds of schools in the US, Australia, Canada, England, and Japan have participated in the TIE program, remotely controlling the 24-inch telescope at the Mount Wilson Observatory from their classrooms. In recent years, several (approximately 20 to date) other telescopes have been, or are in the process of being, outfitted for remote use as TIE affiliates. Global TIE integrates these telescopes seamlessly into one virtual observatory and provides the services required to operate this facility, including a scheduling service, tools for data manipulation, an online proposal review environment, an online "Virtual TIE Student Ap J" for publication of results, and access to related educational materials provided by the TIE community. This presentation describes the Global TIE Observatory data and organizational systems and details the technology, partnerships, operational capabilities, science applications, and learning opportunities that this powerful virtual observatory network will provide.

Simulation Experiments in Practice : Statistical Design and Regression Analysis

NARCIS (Netherlands)

Kleijnen, J.P.C.

2007-01-01

In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. Statistical theory proves that more information is obtained when applying Design Of Experiments (DOE) and linear regression analysis. Unfortunately, classic

Knotcraft the practical and entertaining art of tying knots

CERN Document Server

Macfarlan, Allan and Paulette

1983-01-01

Comprehensive reference work explains how to tie hundreds of practical (and decorative) knots in clear illustrations and precisely worded written instructions. Ideal for boaters and campers. Also covers knots in history, knot mystery and magic, and games, stunts and tricks with rope. Introduction. Index. 166 black-and-white illustrations.

Statistical analysis of the Ft. Calhoun reactor coolant pump system

International Nuclear Information System (INIS)

Patel, Bimal; Heising, C.D.

1997-01-01

In engineering science, statistical quality control techniques have traditionally been applied to control manufacturing processes. An application to commercial nuclear power plant maintenance and control is presented that can greatly improve plant safety. As a demonstration of such an approach, a specific system is analyzed: the reactor coolant pumps (RCPs) of the Ft. Calhoun nuclear power plant. This research uses capability analysis, Shewhart X-bar, R charts, canonical correlation methods, and design of experiments to analyze the process for the state of statistical control. The results obtained show that six out of ten parameters are under control specification limits and four parameters are not in the state of statistical control. The analysis shows that statistical process control methods can be applied as an early warning system capable of identifying significant equipment problems well in advance of traditional control room alarm indicators. Such a system would provide operators with ample time to respond to possible emergency situations and thus improve plant safety and reliability. (Author)

Research and Development of Statistical Analysis Software System of Maize Seedling Experiment

OpenAIRE

Hui Cao

2014-01-01

In this study, software engineer measures were used to develop a set of software system for maize seedling experiments statistics and analysis works. During development works, B/S structure software design method was used and a set of statistics indicators for maize seedling evaluation were established. The experiments results indicated that this set of software system could finish quality statistics and analysis for maize seedling very well. The development of this software system explored a...

Ties That Bind: Creating and sustaining community-academic partnerships

Directory of Open Access Journals (Sweden)

Kynna N. Wright

2011-11-01

Full Text Available Growing interest among academics and health professionals in finding new ways to study and address complex health and social problems has manifested in recent years with increasing community demands for research and program implementation that is community-based, rather than merely community placed. In the United States, community-based participatory research (CBPR, with its emphasis on the creation and use of community-university or community-academic partnerships, is the prevailing paradigm to address these complex problems, especially those concerning racial/ethnic disparities in health and health care. While the need to strengthen the relationship between researchers and the community has been recognised, often from the viewpoint of the university partner, discussions on sustainability of partnerships have been few. The aim of this paper is to share reflections, through the eyes of the community members, on the core elements that tie community and academic members together and the challenges in understanding and nurturing those ties so that the community-academic partnership is sustained over time, and to offer possible recommendations for sustainability. This article speaks from the community’s perspective and reflects on the vital elements/components that tie together community-university partnerships and the challenges that may occur when trying to sustain and grow the partnership. It is based on a research CBPR study that was conducted to (1 evaluate the functioning and future sustainability of the community-university partnership of the Community Child Health Network Study Los Angeles (CCHN-LA community-university partnership, and (2 evaluate the experience and beliefs of the current CCHN-LA community-university partnership members in their understanding of current functioning. Keywords Community-academic partnerships; sustainability; challenges; solutions

Predicting a dissociative disorder from type of childhood maltreatment and abuser-abused relational tie.

Science.gov (United States)

Krüger, Christa; Fletcher, Lizelle

2017-01-01

We investigate the types of childhood maltreatment and abuser-abused relational ties that best predict a dissociative disorder (DD). Psychiatric inpatients (n = 116; mean age = 35; F:M = 1.28:1) completed measures of dissociation and trauma. Abuse type and abuser-abused relational ties were recorded in the Traumatic Experiences Questionnaire. Multidisciplinary team clinical diagnosis or administration of the SCID-D-R to high dissociators confirmed DD diagnoses. Logit models described the relationships between abuser-abused relational tie and the diagnostic grouping of patients, DD present (n = 16) or DD absent (n = 100). Fisher's exact tests measured the relative contribution of specific abuse types. There was a positive relationship between abuse frequency and the presence of DD. DD patients experienced more abuse than patients without DDs. Two combinations of abuse type and relational tie predicted a DD: childhood emotional neglect by biological parents/siblings and later emotional abuse by intimate partners. These findings support the early childhood etiology of DDs and subsequent maladaptive cycles of adult abuse. Enquiries about childhood maltreatment should include a history of emotional neglect by biological parents/siblings. Adult emotional abuse by intimate partners should assist in screening for DDs.

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

Science.gov (United States)

Venneri, Mary Anna; De Palma, Michele; Ponzoni, Maurilio; Pucci, Ferdinando; Scielzo, Cristina; Zonari, Erika; Mazzieri, Roberta; Doglioni, Claudio; Naldini, Luigi

2007-06-15

Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have been implicated in tumor progression. We recently described a lineage of mouse monocytes characterized by expression of the Tie2 angiopoietin receptor and required for the vascularization and growth of several tumor models. Here, we report that TIE2 expression in human blood identifies a subset of monocytes distinct from classical inflammatory monocytes and comprised within the less abundant "resident" population. These TIE2-expressing monocytes (TEMs) accounted for 2% to 7% of blood mononuclear cells in healthy donors and were distinct from rare circulating endothelial cells and progenitors. In human cancer patients, TEMs were observed in the blood and, intriguingly, within the tumors, where they represented the main monocyte population distinct from TAMs. Conversely, TEMs were hardly detected in nonneoplastic tissues. In vitro, TEMs migrated toward angiopoietin-2, a TIE2 ligand released by activated endothelial cells and angiogenic vessels, suggesting a homing mechanism for TEMs to tumors. Purified human TEMs, but not TEM-depleted monocytes, markedly promoted angiogenesis in xenotransplanted human tumors, suggesting a potentially critical role of TEMs in human cancer progression. Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy.

Statistical trend analysis methods for temporal phenomena

Energy Technology Data Exchange (ETDEWEB)

Lehtinen, E.; Pulkkinen, U. [VTT Automation, (Finland); Poern, K. [Poern Consulting, Nykoeping (Sweden)

1997-04-01

We consider point events occurring in a random way in time. In many applications the pattern of occurrence is of intrinsic interest as indicating a trend or some other systematic feature in the rate of occurrence. The purpose of this report is to survey briefly different statistical trend analysis methods and illustrate their applicability to temporal phenomena in particular. The trend testing of point events is usually seen as the testing of the hypotheses concerning the intensity of the occurrence of events. When the intensity function is parametrized, the testing of trend is a typical parametric testing problem. In industrial applications the operational experience generally does not suggest any specified model and method in advance. Therefore, and particularly, if the Poisson process assumption is very questionable, it is desirable to apply tests that are valid for a wide variety of possible processes. The alternative approach for trend testing is to use some non-parametric procedure. In this report we have presented four non-parametric tests: The Cox-Stuart test, the Wilcoxon signed ranks test, the Mann test, and the exponential ordered scores test. In addition to the classical parametric and non-parametric approaches we have also considered the Bayesian trend analysis. First we discuss a Bayesian model, which is based on a power law intensity model. The Bayesian statistical inferences are based on the analysis of the posterior distribution of the trend parameters, and the probability of trend is immediately seen from these distributions. We applied some of the methods discussed in an example case. It should be noted, that this report is a feasibility study rather than a scientific evaluation of statistical methods, and the examples can only be seen as demonstrations of the methods. 14 refs, 10 figs.

Statistical trend analysis methods for temporal phenomena

International Nuclear Information System (INIS)

Lehtinen, E.; Pulkkinen, U.; Poern, K.

1997-04-01

We consider point events occurring in a random way in time. In many applications the pattern of occurrence is of intrinsic interest as indicating a trend or some other systematic feature in the rate of occurrence. The purpose of this report is to survey briefly different statistical trend analysis methods and illustrate their applicability to temporal phenomena in particular. The trend testing of point events is usually seen as the testing of the hypotheses concerning the intensity of the occurrence of events. When the intensity function is parametrized, the testing of trend is a typical parametric testing problem. In industrial applications the operational experience generally does not suggest any specified model and method in advance. Therefore, and particularly, if the Poisson process assumption is very questionable, it is desirable to apply tests that are valid for a wide variety of possible processes. The alternative approach for trend testing is to use some non-parametric procedure. In this report we have presented four non-parametric tests: The Cox-Stuart test, the Wilcoxon signed ranks test, the Mann test, and the exponential ordered scores test. In addition to the classical parametric and non-parametric approaches we have also considered the Bayesian trend analysis. First we discuss a Bayesian model, which is based on a power law intensity model. The Bayesian statistical inferences are based on the analysis of the posterior distribution of the trend parameters, and the probability of trend is immediately seen from these distributions. We applied some of the methods discussed in an example case. It should be noted, that this report is a feasibility study rather than a scientific evaluation of statistical methods, and the examples can only be seen as demonstrations of the methods

Assessment of the possible contribution of space ties on-board GNSS satellites to the terrestrial reference frame

Science.gov (United States)

Bruni, Sara; Rebischung, Paul; Zerbini, Susanna; Altamimi, Zuheir; Errico, Maddalena; Santi, Efisio

2018-04-01

The realization of the international terrestrial reference frame (ITRF) is currently based on the data provided by four space geodetic techniques. The accuracy of the different technique-dependent materializations of the frame physical parameters (origin and scale) varies according to the nature of the relevant observables and to the impact of technique-specific errors. A reliable computation of the ITRF requires combining the different inputs, so that the strengths of each technique can compensate for the weaknesses of the others. This combination, however, can only be performed providing some additional information which allows tying together the independent technique networks. At present, the links used for that purpose are topometric surveys (local/terrestrial ties) available at ITRF sites hosting instruments of different techniques. In principle, a possible alternative could be offered by spacecrafts accommodating the positioning payloads of multiple geodetic techniques realizing their co-location in orbit (space ties). In this paper, the GNSS-SLR space ties on-board GPS and GLONASS satellites are thoroughly examined in the framework of global reference frame computations. The investigation focuses on the quality of the realized physical frame parameters. According to the achieved results, the space ties on-board GNSS satellites cannot, at present, substitute terrestrial ties in the computation of the ITRF. The study is completed by a series of synthetic simulations investigating the impact that substantial improvements in the volume and quality of SLR observations to GNSS satellites would have on the precision of the GNSS frame parameters.

75 FR 34941 - Review of the Commission's Program Access Rules and Examination of Programming Tying Arrangements

Science.gov (United States)

2010-06-21

... Commission's Program Access Rules and Examination of Programming Tying Arrangements AGENCY: Federal... Program Access Rules and Examination of Programming Tying Arrangements, MB Docket No. 07-198, FCC 10-17... information collection is contained in Sections 4(i), 303(r), and 628 of the Communications Act of 1934, as...

DO TIE LABORATORY BASED ASSESSMENT METHODS REALLY PREDICT FIELD EFFECTS?

Science.gov (United States)

Sediment Toxicity Identification and Evaluation (TIE) methods have been developed for both porewaters and whole sediments. These relatively simple laboratory methods are designed to identify specific toxicants or classes of toxicants in sediments; however, the question of whethe...

Analytic models for beam propagation and far-field patterns in slab and bow-tie x-ray lasers

International Nuclear Information System (INIS)

Chandler, E.A.

1994-06-01

Simplified analytic models for beam propagation in slab and bow-tie x-ray lasers yield convenient expressions that provide both a framework for guidance in computer modeling and useful approximates for experimenters. In unrefracted bow-tie lasers, the laser shape in conjunction with the nearly-exponential weighting of rays according to their length produces a small effective aperture for the signal. We develop an analytic expression for the aperture and the properties of the far-field signal. Similarly, we develop the view that the far-field pattern of refractive slab lasers is the result of effective apertures that are created by the interplay of refraction and exponential amplification. We present expressions for the size of this aperture as a function of laser parameters as well as for the intensity and position of the far-field lineout. This analysis also yields conditions for the refraction limit in slab lasers and an estimate for the signal loss due to refraction

StOCNET : Software for the statistical analysis of social networks

NARCIS (Netherlands)

Huisman, M.; van Duijn, M.A.J.

2003-01-01

StOCNET3 is an open software system in a Windows environment for the advanced statistical analysis of social networks. It provides a platform to make a number of recently developed and therefore not (yet) standard statistical methods available to a wider audience. A flexible user interface utilizing

AutoBayes: A System for Generating Data Analysis Programs from Statistical Models

OpenAIRE

Fischer, Bernd; Schumann, Johann

2003-01-01

Data analysis is an important scientific task which is required whenever information needs to be extracted from raw data. Statistical approaches to data analysis, which use methods from probability theory and numerical analysis, are well-founded but dificult to implement: the development of a statistical data analysis program for any given application is time-consuming and requires substantial knowledge and experience in several areas. In this paper, we describe AutoBayes, a program synthesis...

Rural-urban migration in Zambia and migrant ties to home villages.

Science.gov (United States)

Ogura, M

1991-06-01

Rural to urban migration patterns in Zambia and migrant ties to home villages are discussed 1st in terms of a statistical overview of migration and urbanization, and followed by an examination of lengthening stays in towns and ties to the home village based on other studies and the author's field research and random sampling in 6 urban areas of Zambia. The primary population centers are the copperbelt which comprises 45% of the total urban population, and Lusaka which is 24% of the total urban population. 31% of the total population reside in Lusaka, 7 mining towns, Kabwe, and Livingstone. Migration and a high rate of natural population growth are responsible for the urban growth. Recent economic difficulties have reduced the flow of migration to urban areas and lead to the out migration in copper towns. independence also has had an effect on migration, such that female migration increased along with male migration. Female migration reflects female educational advances and the changing practice of housewives accompanying husbands. The informal sector absorbs a great number of the migrant labor force. Income gaps between urban and rural areas also contribute to migration flows. Other magnets in urban areas are better educational opportunities, a water supply, and the lure of city lights. Since independence, migrants have increased their length of stay in towns but continue to maintain links with their home villages. 87.5% of mine workers are estimated as intending to go back to their villages. Before the mid-1970s it is estimated in a Ngombe squatter camp that 65% of employed male household heads had sent money home the prior year, 58% had visited home within the past 5 years, but 25% had never visited in 10 years. 58% intended to return home and 36% intended to stay permanently. The author's research between 1987-89 found 3 types of squatter villages: those retired and not returning to home villages such as Kansusuwa, those workers living in compounds where farm

Network similarity and statistical analysis of earthquake seismic data

OpenAIRE

Deyasi, Krishanu; Chakraborty, Abhijit; Banerjee, Anirban

2016-01-01

We study the structural similarity of earthquake networks constructed from seismic catalogs of different geographical regions. A hierarchical clustering of underlying undirected earthquake networks is shown using Jensen-Shannon divergence in graph spectra. The directed nature of links indicates that each earthquake network is strongly connected, which motivates us to study the directed version statistically. Our statistical analysis of each earthquake region identifies the hub regions. We cal...

Statistical analysis and interpolation of compositional data in materials science.

Science.gov (United States)

Pesenson, Misha Z; Suram, Santosh K; Gregoire, John M

2015-02-09

Compositional data are ubiquitous in chemistry and materials science: analysis of elements in multicomponent systems, combinatorial problems, etc., lead to data that are non-negative and sum to a constant (for example, atomic concentrations). The constant sum constraint restricts the sampling space to a simplex instead of the usual Euclidean space. Since statistical measures such as mean and standard deviation are defined for the Euclidean space, traditional correlation studies, multivariate analysis, and hypothesis testing may lead to erroneous dependencies and incorrect inferences when applied to compositional data. Furthermore, composition measurements that are used for data analytics may not include all of the elements contained in the material; that is, the measurements may be subcompositions of a higher-dimensional parent composition. Physically meaningful statistical analysis must yield results that are invariant under the number of composition elements, requiring the application of specialized statistical tools. We present specifics and subtleties of compositional data processing through discussion of illustrative examples. We introduce basic concepts, terminology, and methods required for the analysis of compositional data and utilize them for the spatial interpolation of composition in a sputtered thin film. The results demonstrate the importance of this mathematical framework for compositional data analysis (CDA) in the fields of materials science and chemistry.

An Application of Multivariate Statistical Analysis for Query-Driven Visualization

Energy Technology Data Exchange (ETDEWEB)

Gosink, Luke J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Garth, Christoph [Univ. of California, Davis, CA (United States); Anderson, John C. [Univ. of California, Davis, CA (United States); Bethel, E. Wes [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Joy, Kenneth I. [Univ. of California, Davis, CA (United States)

2011-03-01

Driven by the ability to generate ever-larger, increasingly complex data, there is an urgent need in the scientific community for scalable analysis methods that can rapidly identify salient trends in scientific data. Query-Driven Visualization (QDV) strategies are among the small subset of techniques that can address both large and highly complex datasets. This paper extends the utility of QDV strategies with a statistics-based framework that integrates non-parametric distribution estimation techniques with a new segmentation strategy to visually identify statistically significant trends and features within the solution space of a query. In this framework, query distribution estimates help users to interactively explore their query's solution and visually identify the regions where the combined behavior of constrained variables is most important, statistically, to their inquiry. Our new segmentation strategy extends the distribution estimation analysis by visually conveying the individual importance of each variable to these regions of high statistical significance. We demonstrate the analysis benefits these two strategies provide and show how they may be used to facilitate the refinement of constraints over variables expressed in a user's query. We apply our method to datasets from two different scientific domains to demonstrate its broad applicability.

The Running Barbed Tie-over Dressing.

Science.gov (United States)

Joyce, Cormac W; Joyce, Kenneth M; Kennedy, Ann-Marie; Kelly, Jack L

2014-04-01

Barbed suture technology is becoming increasingly popular in plastic surgery and is now being used in body contouring surgery and facial rejuvenation. We describe the novel application of a barbed suture as a running tie-over dressing for skin grafts. The barbs act as anchors in the skin, so constant tensioning of the suture is not required. The bidirectional nature of the suture prevents any slippage, and the barbs even act as a grip on the underlying wool dressing. Furthermore, the method described is both quick and simple to learn and would be useful for the sole operator.

The Running Barbed Tie-over Dressing

Directory of Open Access Journals (Sweden)

Cormac W. Joyce, MB, BCh, MRCSI

2014-04-01

Full Text Available Summary: Barbed suture technology is becoming increasingly popular in plastic surgery and is now being used in body contouring surgery and facial rejuvenation. We describe the novel application of a barbed suture as a running tie-over dressing for skin grafts. The barbs act as anchors in the skin, so constant tensioning of the suture is not required. The bidirectional nature of the suture prevents any slippage, and the barbs even act as a grip on the underlying wool dressing. Furthermore, the method described is both quick and simple to learn and would be useful for the sole operator.

Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.

Science.gov (United States)

Forget, Mary A; Voorhees, Jeffrey L; Cole, Sara L; Dakhlallah, Duaa; Patterson, Ivory L; Gross, Amy C; Moldovan, Leni; Mo, Xiaokui; Evans, Randall; Marsh, Clay B; Eubank, Tim D

2014-01-01

Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be predominantly expressed on endothelial cells, has been characterized. We hypothesized that increased levels of CSF1 in breast tumors can regulate differentiation of Tie2- monocytes to a Tie2+ phenotype. We treated CD14+ human monocytes with CSF1 and found a significant increase in CD14+/Tie2+ positivity. To understand if CSF1-induced Tie2 expression on these cells improved their migratory ability, we pre-treated CD14+ monocytes with CSF1 and used Boyden chemotaxis chambers to observe enhanced response to angiopoietin-2 (ANG2), the chemotactic ligand for the Tie2 receptor. We found that CSF1 pre-treatment significantly augmented chemotaxis and that Tie2 receptor upregulation was responsible as siRNA targeting Tie2 receptor abrogated this effect. To understand any augmented angiogenic effect produced by treating these cells with CSF1, we cultured human umbilical vein endothelial cells (HUVECs) with conditioned supernatants from CSF1-pre-treated CD14+ monocytes for a tube formation assay. While supernatants from CSF1-pre-treated TEMs increased HUVEC branching, a neutralizing antibody against the CSF1R abrogated this activity, as did siRNA against the Tie2 receptor. To test our hypothesis in vivo, we treated PyMT tumor-bearing mice with CSF1 and observed an expansion in the TEM population relative to total F4/80+ cells, which resulted in increased angiogenesis. Investigation into the mechanism of Tie2 receptor upregulation on CD14+ monocytes by CSF1 revealed a synergistic contribution from the PI3 kinase and HIF pathways as the PI3 kinase inhibitor LY294002, as well as HIF-1α-deficient macrophages differentiated from the bone marrow of HIF-1αfl/fl/LysMcre mice, diminished CSF1-stimulated Tie2 receptor expression.

The effects of individual status and group performance on network ties among teammates in the National Basketball Association.

Directory of Open Access Journals (Sweden)

Jeremy Koster

Full Text Available For individuals, status is derived both from their personal attributes and the groups with whom they are affiliated. Depending on the performance of their groups, the status of individuals may benefit or suffer from identifying closely with the group. When the group excels, high-status members potentially receive much of the credit and increased status. Conversely, high-status members of underperforming groups potentially suffer disproportionate declines in their status relative to the low-status group members. We therefore predict an interaction between group performance and individual status on the willingness to associate with the group and its members. We test our prediction by examining social media ties among teammates in the National Basketball Association. Specifically, we investigate the "following" ties of teammates on Twitter at the end of the 2014-2015 season. Elections to All-Star games are used to measure the status of players, and team performance is measured by recent success in the postseason playoffs. The results show that compared to high-status players on successful teams, high-status players on underperforming teams are less likely to follow their teammates. This result aligns with research on status inconsistency, suggesting that individuals deemphasize their group affiliation when it jeopardizes their individual status. An additional contribution is the advancement of the probit Social Relations Model for the analysis of binary ties in social networks.

The effects of individual status and group performance on network ties among teammates in the National Basketball Association.

Science.gov (United States)

Koster, Jeremy; Aven, Brandy

2018-01-01

For individuals, status is derived both from their personal attributes and the groups with whom they are affiliated. Depending on the performance of their groups, the status of individuals may benefit or suffer from identifying closely with the group. When the group excels, high-status members potentially receive much of the credit and increased status. Conversely, high-status members of underperforming groups potentially suffer disproportionate declines in their status relative to the low-status group members. We therefore predict an interaction between group performance and individual status on the willingness to associate with the group and its members. We test our prediction by examining social media ties among teammates in the National Basketball Association. Specifically, we investigate the "following" ties of teammates on Twitter at the end of the 2014-2015 season. Elections to All-Star games are used to measure the status of players, and team performance is measured by recent success in the postseason playoffs. The results show that compared to high-status players on successful teams, high-status players on underperforming teams are less likely to follow their teammates. This result aligns with research on status inconsistency, suggesting that individuals deemphasize their group affiliation when it jeopardizes their individual status. An additional contribution is the advancement of the probit Social Relations Model for the analysis of binary ties in social networks.

Neural dynamics of social tie formation in economic decision-making

NARCIS (Netherlands)

Bault, N.; Pelloux, B.; Fahrenfort, J.J.; Ridderinkhof, K.R.; van Winden, F.

2015-01-01

The disposition for prosocial conduct, which contributes to cooperation as arising during social interaction, requires cortical network dynamics responsive to the development of social ties, or care about the interests of specific interaction partners. Here, we formulate a dynamic computational

A Simplified Control Method for Tie-Line Power of DC Micro-Grid

Directory of Open Access Journals (Sweden)

Yanbo Che

2018-04-01

Full Text Available Compared with the AC micro-grid, the DC micro-grid has low energy loss and no issues of frequency stability, which makes it more accessible for distributed energy. Thus, the DC micro-grid has good potential for development. A variety of renewable energy is included in the DC micro-grid, which is easily affected by the environment, causing fluctuation of the DC voltage. For grid-connected DC micro-grid with droop control strategy, the tie-line power is affected by fluctuations in the DC voltage, which sets higher requirements for coordinated control of the DC micro-grid. This paper presents a simplified control method to maintain a constant tie-line power that is suitable for the DC micro-grid with the droop control strategy. By coordinating the designs of the droop control characteristics of generators, energy storage units and grid-connected inverter, a dead band is introduced to the droop control to improve the system performance. The tie-line power in the steady state is constant. When a large disturbance occurs, the AC power grid can provide power support to the micro-grid in time. The simulation example verifies the effectiveness of the proposed control strategy.

Explorations in Statistics: The Analysis of Ratios and Normalized Data

Science.gov (United States)

Curran-Everett, Douglas

2013-01-01

Learning about statistics is a lot like learning about science: the learning is more meaningful if you can actively explore. This ninth installment of "Explorations in Statistics" explores the analysis of ratios and normalized--or standardized--data. As researchers, we compute a ratio--a numerator divided by a denominator--to compute a…

Competition increases in the face of strong regional ties

International Nuclear Information System (INIS)

Knoetgen, P.M.

1987-01-01

The current fuel market exhibits a large surplus production capacity and is strongly influenced by regional ties, with imports of fabricated fuel serving to supplement domestic production or to keep domestic vendors competitive. In the future, the market is set to become increasingly competitive, especially in Europe and the United States. (author)

Statistical Energy Analysis (SEA) and Energy Finite Element Analysis (EFEA) Predictions for a Floor-Equipped Composite Cylinder

Science.gov (United States)

Grosveld, Ferdinand W.; Schiller, Noah H.; Cabell, Randolph H.

2011-01-01

Comet Enflow is a commercially available, high frequency vibroacoustic analysis software founded on Energy Finite Element Analysis (EFEA) and Energy Boundary Element Analysis (EBEA). Energy Finite Element Analysis (EFEA) was validated on a floor-equipped composite cylinder by comparing EFEA vibroacoustic response predictions with Statistical Energy Analysis (SEA) and experimental results. Statistical Energy Analysis (SEA) predictions were made using the commercial software program VA One 2009 from ESI Group. The frequency region of interest for this study covers the one-third octave bands with center frequencies from 100 Hz to 4000 Hz.

Simulation Experiments in Practice : Statistical Design and Regression Analysis

NARCIS (Netherlands)

Kleijnen, J.P.C.

2007-01-01

In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because statistical theory proves that more information is

Statistical trend analysis methodology for rare failures in changing technical systems

International Nuclear Information System (INIS)

Ott, K.O.; Hoffmann, H.J.

1983-07-01

A methodology for a statistical trend analysis (STA) in failure rates is presented. It applies primarily to relatively rare events in changing technologies or components. The formulation is more general and the assumptions are less restrictive than in a previously published version. Relations of the statistical analysis and probabilistic assessment (PRA) are discussed in terms of categorization of decisions for action following particular failure events. The significance of tentatively identified trends is explored. In addition to statistical tests for trend significance, a combination of STA and PRA results quantifying the trend complement is proposed. The STA approach is compared with other concepts for trend characterization. (orig.)

REGISTRATION OF LASER SCANNING POINT CLOUDS AND AERIAL IMAGES USING EITHER ARTIFICIAL OR NATURAL TIE FEATURES

Directory of Open Access Journals (Sweden)

P. Rönnholm

2012-07-01

Full Text Available Integration of laser scanning data and photographs is an excellent combination regarding both redundancy and complementary. Applications of integration vary from sensor and data calibration to advanced classification and scene understanding. In this research, only airborne laser scanning and aerial images are considered. Currently, the initial registration is solved using direct orientation sensors GPS and inertial measurements. However, the accuracy is not usually sufficient for reliable integration of data sets, and thus the initial registration needs to be improved. A registration of data from different sources requires searching and measuring of accurate tie features. Usually, points, lines or planes are preferred as tie features. Therefore, the majority of resent methods rely highly on artificial objects, such as buildings, targets or road paintings. However, in many areas no such objects are available. For example in forestry areas, it would be advantageous to be able to improve registration between laser data and images without making additional ground measurements. Therefore, there is a need to solve registration using only natural features, such as vegetation and ground surfaces. Using vegetation as tie features is challenging, because the shape and even location of vegetation can change because of wind, for example. The aim of this article was to compare registration accuracies derived by using either artificial or natural tie features. The test area included urban objects as well as trees and other vegetation. In this area, two registrations were performed, firstly, using mainly built objects and, secondly, using only vegetation and ground surface. The registrations were solved applying the interactive orientation method. As a result, using artificial tie features leaded to a successful registration in all directions of the coordinate system axes. In the case of using natural tie features, however, the detection of correct heights was

Analysis of thrips distribution: application of spatial statistics and Kriging

Science.gov (United States)

John Aleong; Bruce L. Parker; Margaret Skinner; Diantha Howard

1991-01-01

Kriging is a statistical technique that provides predictions for spatially and temporally correlated data. Observations of thrips distribution and density in Vermont soils are made in both space and time. Traditional statistical analysis of such data assumes that the counts taken over space and time are independent, which is not necessarily true. Therefore, to analyze...

Statistical wind analysis for near-space applications

Science.gov (United States)

Roney, Jason A.

2007-09-01

Statistical wind models were developed based on the existing observational wind data for near-space altitudes between 60 000 and 100 000 ft (18 30 km) above ground level (AGL) at two locations, Akon, OH, USA, and White Sands, NM, USA. These two sites are envisioned as playing a crucial role in the first flights of high-altitude airships. The analysis shown in this paper has not been previously applied to this region of the stratosphere for such an application. Standard statistics were compiled for these data such as mean, median, maximum wind speed, and standard deviation, and the data were modeled with Weibull distributions. These statistics indicated, on a yearly average, there is a lull or a “knee” in the wind between 65 000 and 72 000 ft AGL (20 22 km). From the standard statistics, trends at both locations indicated substantial seasonal variation in the mean wind speed at these heights. The yearly and monthly statistical modeling indicated that Weibull distributions were a reasonable model for the data. Forecasts and hindcasts were done by using a Weibull model based on 2004 data and comparing the model with the 2003 and 2005 data. The 2004 distribution was also a reasonable model for these years. Lastly, the Weibull distribution and cumulative function were used to predict the 50%, 95%, and 99% winds, which are directly related to the expected power requirements of a near-space station-keeping airship. These values indicated that using only the standard deviation of the mean may underestimate the operational conditions.

78 FR 75547 - Prestressed Concrete Steel Rail Tie Wire From Thailand: Preliminary Determination of Sales at Not...

Science.gov (United States)

2013-12-12

... DEPARTMENT OF COMMERCE International Trade Administration [A-549-829] Prestressed Concrete Steel...'') preliminarily determines that prestressed concrete steel rail tire wire (``PC tie wire'') from Thailand is not... shape, size or alloy element levels; suitable for use as prestressed tendons in concrete railroad ties...

Analysis of photon statistics with Silicon Photomultiplier

International Nuclear Information System (INIS)

D'Ascenzo, N.; Saveliev, V.; Wang, L.; Xie, Q.

2015-01-01

The Silicon Photomultiplier (SiPM) is a novel silicon-based photodetector, which represents the modern perspective of low photon flux detection. The aim of this paper is to provide an introduction on the statistical analysis methods needed to understand and estimate in quantitative way the correct features and description of the response of the SiPM to a coherent source of light

Development of statistical analysis code for meteorological data (W-View)

International Nuclear Information System (INIS)

Tachibana, Haruo; Sekita, Tsutomu; Yamaguchi, Takenori

2003-03-01

A computer code (W-View: Weather View) was developed to analyze the meteorological data statistically based on 'the guideline of meteorological statistics for the safety analysis of nuclear power reactor' (Nuclear Safety Commission on January 28, 1982; revised on March 29, 2001). The code gives statistical meteorological data to assess the public dose in case of normal operation and severe accident to get the license of nuclear reactor operation. This code was revised from the original code used in a large office computer code to enable a personal computer user to analyze the meteorological data simply and conveniently and to make the statistical data tables and figures of meteorology. (author)

Statistical analysis of the Ft. Calhoun reactor coolant pump system

International Nuclear Information System (INIS)

Heising, Carolyn D.

1998-01-01

In engineering science, statistical quality control techniques have traditionally been applied to control manufacturing processes. An application to commercial nuclear power plant maintenance and control is presented that can greatly improve plant safety. As a demonstration of such an approach to plant maintenance and control, a specific system is analyzed: the reactor coolant pumps (RCPs) of the Ft. Calhoun nuclear power plant. This research uses capability analysis, Shewhart X-bar, R-charts, canonical correlation methods, and design of experiments to analyze the process for the state of statistical control. The results obtained show that six out of ten parameters are under control specifications limits and four parameters are not in the state of statistical control. The analysis shows that statistical process control methods can be applied as an early warning system capable of identifying significant equipment problems well in advance of traditional control room alarm indicators Such a system would provide operators with ample time to respond to possible emergency situations and thus improve plant safety and reliability. (author)

Damping Methods for Resonances Caused by LCL-Filter-Based Current-Controlled Grid-Tied Power Inverters

DEFF Research Database (Denmark)

Wu, Weimin; Liu, Yuan; He, Yuanbin

2017-01-01

Grid-tied voltage source inverters using LCL filter have been widely adopted in distributed power generation systems (DPGSs). As high-order LCL filters contain multiple resonant frequencies, switching harmonics generated by the inverter and current harmonics generated by the active/passive loads...... innovative damping methods have been proposed. A comprehensive overview on those contributions and their classification on the inverter- and grid-side damping measures are presented. Based on the concept of the impedance-based stability analysis, all damping methods can ensure the system stability...

Quiet eye training improves surgical knot tying more than traditional technical training: a randomized controlled study.

Science.gov (United States)

Causer, Joe; Harvey, Adrian; Snelgrove, Ryan; Arsenault, Gina; Vickers, Joan N

2014-08-01

We examined the effectiveness of technical training (TT) and quiet eye training (QE) on the performance of one-handed square knot tying in surgical residents. Twenty surgical residents were randomly assigned to the 2 groups and completed pretest, training, retention, and transfer tests. Participants wore a mobile eye tracker that simultaneously recorded their gaze and hand movements. Dependent variables were knot tying performance (%), QE duration (%), number of fixations, total movement time (s), and hand movement phase time (s). The QE training group had significantly higher performance scores, a longer QE duration, fewer fixations, faster total knot tying times, and faster movement phase times compared with the TT group. The QE group maintained performance in the transfer test, whereas the TT group significantly decreased performance from retention to transfer. QE training significantly improved learning, retention, and transfer of surgical knot tying compared with a traditional technical approach. Both performance effectiveness (performance outcome) and movement efficiency (hand movement times) were improved using QE modeling, instruction, and feedback. Copyright © 2014 Elsevier Inc. All rights reserved.

A matched Bow-tie antenna at 433MHz for use in underwater wireless sensor networks

International Nuclear Information System (INIS)

Abdou, A A; Shaw, A; Mason, A; Al-Shamma'a, A; Cullen, J; Wylie, S; Diallo, M

2013-01-01

Electromagnetic (EM) wave propagation underwater is been disregarded because of attenuation at high frequencies, however the theory predicts that propagation is possible at some useful distance in the lower Industrial, Scientific and Medical (ISM) band. Common transceivers rely on narrowband antennas and matching circuit. The aim of this paper is to design a broadband 433MHz bow-tie antenna and experiment it in air and water without a matching circuit. This antenna could be attached to wireless transceivers and form a Wireless Sensor Network for deployment in various underwater applications. The bow-tie antennas were designed, simulated and constructed in laboratory. Experiments were setup carefully by using a completely isolated transmitter from electronics to avoid airborne transmission. The 433MHz. bow-tie proved its suitability for use in Underwater.

Terahertz-wave near-field imaging with subwavelength resolution using surface-wave-assisted bow-tie aperture

Science.gov (United States)

Ishihara, Kunihiko; Ohashi, Keishi; Ikari, Tomofumi; Minamide, Hiroaki; Yokoyama, Hiroyuki; Shikata, Jun-ichi; Ito, Hiromasa

2006-11-01

We demonstrate the terahertz-wave near-field imaging with subwavelength resolution using a bow-tie shaped aperture surrounded by concentric periodic structures in a metal film. A subwavelength aperture with concentric periodic grooves, which are known as a bull's eye structure, shows extremely large enhanced transmission beyond the diffraction limit caused by the resonant excitation of surface waves. Additionally, a bow-tie aperture exhibits extraordinary field enhancement at the sharp tips of the metal, which enhances the transmission and the subwavelength spatial resolution. We introduced a bow-tie aperture to the bull's eye structure and achieved high spatial resolution (˜λ/17) in the near-field region. The terahertz-wave near-field image of the subwavelength metal pattern (pattern width=20μm) was obtained for the wavelength of 207μm.

One Step Solution to the Local Tie Vectors of GNSS/SLR in ITRF

Directory of Open Access Journals (Sweden)

MA Xiaping

2018-01-01

Full Text Available This paper proposes a one-step solution of local tie vectors,the solution takes RP (Reference Point and axes offsets of SLR telescope as unknown parameters,GNSS baselines network and conventional terrestrial observation (horizontal,vertical angle and distance are combined in ITRF (International Terrestrial Reference Frame,and multiply constraint conditions are established between RP and observation marks and two axes offsets.Local tie vectors and related covariance matrices of the 3 co-located sites in Beijing,Kunming,Xi'an of CMONOC (Crustal Movement Observation Network of China are solved with the proposed one step solution.The results show that the RMS (root mean square error of local tie vectors is less than 2.0 mm.Besides,the differences are less than 2.0 mm compared with the traditional step by step solution,and the offsets and corresponding RMS between the horizontal axis and vertical axis are 3.8 mm,0.7 mm,3.6 mm and 1.3 mm,1.2 mm,1.3 mm,respectively.

Propensity Score Analysis: An Alternative Statistical Approach for HRD Researchers

Science.gov (United States)

Keiffer, Greggory L.; Lane, Forrest C.

2016-01-01

Purpose: This paper aims to introduce matching in propensity score analysis (PSA) as an alternative statistical approach for researchers looking to make causal inferences using intact groups. Design/methodology/approach: An illustrative example demonstrated the varying results of analysis of variance, analysis of covariance and PSA on a heuristic…

Simulation Experiments in Practice: Statistical Design and Regression Analysis

OpenAIRE

Kleijnen, J.P.C.

2007-01-01

In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because statistical theory proves that more information is obtained when applying Design Of Experiments (DOE) and linear regression analysis. Unfortunately, classic DOE and regression analysis assume a single simulation response that is normally and independen...

In stressful company – Changes in stress and work ties over time

DEFF Research Database (Denmark)

Waldstrøm, Christian; Parker, Andrew; Shah, Neha P.

Recent research on stress and burnout has highlighted the collective aspects of stress symptoms, perceived stress, and coping mechanisms. Much of this work, however, is focused on group and team dynamics rather than how network factors shape individuals’ feelings of stress and burnout. We use...... a stress questionnaire and social network analysis at three time points in a Scandinavian biotechnology company to examine the interactions between stress and relationship development and maintenance over time. We show that individuals tend to form and maintain ties to people who are less stressed than...... they are, indicating that while misery might love company, stress does not. Given the longitudinal nature of the study, we’re able to disentangle the causal effects....

Statistical analysis of thermal conductivity of nanofluid containing ...

Indian Academy of Sciences (India)

Thermal conductivity measurements of nanofluids were analysed via two-factor completely randomized design and comparison of data means is carried out with Duncan's multiple-range test. Statistical analysis of experimental data show that temperature and weight fraction have a reasonable impact on the thermal ...

GNSS-SLR satellite co-location for the estimate of local ties

Science.gov (United States)

Bruni, Sara; Zerbini, Susanna; Errico, Maddalena; Santi, Efisio

2013-04-01

The current realization of the International Terrestrial Reference Frame (ITRF) is based on four different space-geodetic techniques, so that the benefits brought by each observing system to the definition of the frame can compensate for the drawbacks of the others and technique-specific systematic errors might be identified. The strategy used to combine the observations from the different techniques is then of prominent importance for the realization of a precise and stable reference frame. This study concentrates, in particular, on the combination of Satellite Laser Ranging (SLR) and Global Navigation Satellite System (GNSS) observations by exploiting satellite co-locations. This innovative approach is based on the fact that laser tracking of GNSS satellites, carrying on board laser reflector arrays, allows for the combination of optical and microwave signals in the determination of the spacecraft orbit. Besides, the use of satellite co-locations differs quite significantly from the traditional combination method in which each single technique solution is carried out autonomously and is interrelated in a second step. One of the benefits of the approach adopted in this study is that it allows for an independent validation of the local tie, i.e. of the vector connecting the SLR and GNSS reference points in a multi-techniques station. Typically, local ties are expressed by a single value, measured with ground-based geodetic techniques and taken as constant. In principle, however, local ties might show time variations likely caused by the different monumentation characteristics of the GNSS antennas with respect to those of a SLR system. This study evaluates the possibility of using the satellite co-location approach to generate local-ties time series by means of observations available for a selected network of ILRS stations. The data analyzed in this study were acquired as part of the NASA's Earth Science Data Systems and are archived and distributed by the Crustal

Longitudinal data analysis a handbook of modern statistical methods

CERN Document Server

Fitzmaurice, Garrett; Verbeke, Geert; Molenberghs, Geert

2008-01-01

Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory and applications. It also focuses on the assorted challenges that arise in analyzing longitudinal data. After discussing historical aspects, leading researchers explore four broad themes: parametric modeling, nonparametric and semiparametric methods, joint

Mathematical statistics

CERN Document Server

Pestman, Wiebe R

2009-01-01

This textbook provides a broad and solid introduction to mathematical statistics, including the classical subjects hypothesis testing, normal regression analysis, and normal analysis of variance. In addition, non-parametric statistics and vectorial statistics are considered, as well as applications of stochastic analysis in modern statistics, e.g., Kolmogorov-Smirnov testing, smoothing techniques, robustness and density estimation. For students with some elementary mathematical background. With many exercises. Prerequisites from measure theory and linear algebra are presented.

Which Peers Matter : How Social Ties Affect Peer-group Effects

NARCIS (Netherlands)

Poldin, O.; Valeeva, D.; Yudkevich, M.

We study how the achievements of university students are influenced by the characteristics and achievements of peers in individuals’ social networks. Defining peer group in terms of friendship and study partner ties enables us to apply a network regression model and thereby disentangle the influence

Bayesian Sensitivity Analysis of Statistical Models with Missing Data.

Science.gov (United States)

Zhu, Hongtu; Ibrahim, Joseph G; Tang, Niansheng

2014-04-01

Methods for handling missing data depend strongly on the mechanism that generated the missing values, such as missing completely at random (MCAR) or missing at random (MAR), as well as other distributional and modeling assumptions at various stages. It is well known that the resulting estimates and tests may be sensitive to these assumptions as well as to outlying observations. In this paper, we introduce various perturbations to modeling assumptions and individual observations, and then develop a formal sensitivity analysis to assess these perturbations in the Bayesian analysis of statistical models with missing data. We develop a geometric framework, called the Bayesian perturbation manifold, to characterize the intrinsic structure of these perturbations. We propose several intrinsic influence measures to perform sensitivity analysis and quantify the effect of various perturbations to statistical models. We use the proposed sensitivity analysis procedure to systematically investigate the tenability of the non-ignorable missing at random (NMAR) assumption. Simulation studies are conducted to evaluate our methods, and a dataset is analyzed to illustrate the use of our diagnostic measures.

Advanced data analysis in neuroscience integrating statistical and computational models

CERN Document Server

Durstewitz, Daniel

2017-01-01

This book is intended for use in advanced graduate courses in statistics / machine learning, as well as for all experimental neuroscientists seeking to understand statistical methods at a deeper level, and theoretical neuroscientists with a limited background in statistics. It reviews almost all areas of applied statistics, from basic statistical estimation and test theory, linear and nonlinear approaches for regression and classification, to model selection and methods for dimensionality reduction, density estimation and unsupervised clustering.  Its focus, however, is linear and nonlinear time series analysis from a dynamical systems perspective, based on which it aims to convey an understanding also of the dynamical mechanisms that could have generated observed time series. Further, it integrates computational modeling of behavioral and neural dynamics with statistical estimation and hypothesis testing. This way computational models in neuroscience are not only explanat ory frameworks, but become powerfu...

Quantitative analysis and IBM SPSS statistics a guide for business and finance

CERN Document Server

Aljandali, Abdulkader

2016-01-01

This guide is for practicing statisticians and data scientists who use IBM SPSS for statistical analysis of big data in business and finance. This is the first of a two-part guide to SPSS for Windows, introducing data entry into SPSS, along with elementary statistical and graphical methods for summarizing and presenting data. Part I also covers the rudiments of hypothesis testing and business forecasting while Part II will present multivariate statistical methods, more advanced forecasting methods, and multivariate methods. IBM SPSS Statistics offers a powerful set of statistical and information analysis systems that run on a wide variety of personal computers. The software is built around routines that have been developed, tested, and widely used for more than 20 years. As such, IBM SPSS Statistics is extensively used in industry, commerce, banking, local and national governments, and education. Just a small subset of users of the package include the major clearing banks, the BBC, British Gas, British Airway...

Toward an integrated ice core chronology using relative and orbital tie-points

Science.gov (United States)

Bazin, L.; Landais, A.; Lemieux-Dudon, B.; Toyé Mahamadou Kele, H.; Blunier, T.; Capron, E.; Chappellaz, J.; Fischer, H.; Leuenberger, M.; Lipenkov, V.; Loutre, M.-F.; Martinerie, P.; Parrenin, F.; Prié, F.; Raynaud, D.; Veres, D.; Wolff, E.

2012-04-01

Precise ice cores chronologies are essential to better understand the mechanisms linking climate change to orbital and greenhouse gases concentration forcing. A tool for ice core dating (DATICE [developed by Lemieux-Dudon et al., 2010] permits to generate a common time-scale integrating relative and absolute dating constraints on different ice cores, using an inverse method. Nevertheless, this method has only been applied for a 4-ice cores scenario and for the 0-50 kyr time period. Here, we present the bases for an extension of this work back to 800 ka using (1) a compilation of published and new relative and orbital tie-points obtained from measurements of air trapped in ice cores and (2) an adaptation of the DATICE inputs to 5 ice cores for the last 800 ka. We first present new measurements of δ18Oatm and δO2/N2 on the Talos Dome and EPICA Dome C (EDC) ice cores with a particular focus on Marine Isotopic Stages (MIS) 5, and 11. Then, we show two tie-points compilations. The first one is based on new and published CH4 and δ18Oatm measurements on 5 ice cores (NorthGRIP, EPICA Dronning Maud Land, EDC, Talos Dome and Vostok) in order to produce a table of relative gas tie-points over the last 400 ka. The second one is based on new and published records of δO2/N2, δ18Oatm and air content to provide a table of orbital tie-points over the last 800 ka. Finally, we integrate the different dating constraints presented above in the DATICE tool adapted to 5 ice cores to cover the last 800 ka and show how these constraints compare with the established gas chronologies of each ice core.

A comparison of tape-tying versus a tube-holding device for securing endotracheal tubes in adults.

Science.gov (United States)

Murdoch, E; Holdgate, A

2007-10-01

During the transfer of intubated patients, endotracheal tube security is paramount. This study aims to compare two methods of securing an endotracheal tube in adults: tying with a cloth tape versus the Thomas Endotracheal Tube Holder (Laerdal). A manikin-based study was performed using paramedics and critical care doctors (consultants and senior trainees) as participants. Each participant was asked to secure an endotracheal tube that had been placed within the trachea of a manikin a total of six times, the first three times using tied cloth tape and the last three times using a Thomas Endotracheal Tube Holder. Following each 'fixation' and after the participant had left the room, the security of the tube was tested by applying a fixed force laterally and to the right by dropping a 1.25 kg weight a distance of 50 cm. The amount of movement of the tube with respect to the teeth was measured and recorded in millimetres. Two-hundred-and-seventy tube fixations (135 tied vs. 135 tube holder) were performed by 45 participants. The degree of tube movement was significantly higher when the tube was secured with a tie compared with when the tube holder was used (median movement 22 mm vs. 4 mm, P tube holder device minimised tube movement in a manikin model when compared with conventional tape tying. The use of this device when transporting intubated patients may reduce the risk of tube displacement though further clinical studies are warranted.

Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.

Directory of Open Access Journals (Sweden)

Mary A Forget

Full Text Available Reports demonstrate the role of M-CSF (CSF1 in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients. Recently, a subset of CD14+ monocytes expressing the Tie2 receptor, once thought to be predominantly expressed on endothelial cells, has been characterized. We hypothesized that increased levels of CSF1 in breast tumors can regulate differentiation of Tie2- monocytes to a Tie2+ phenotype. We treated CD14+ human monocytes with CSF1 and found a significant increase in CD14+/Tie2+ positivity. To understand if CSF1-induced Tie2 expression on these cells improved their migratory ability, we pre-treated CD14+ monocytes with CSF1 and used Boyden chemotaxis chambers to observe enhanced response to angiopoietin-2 (ANG2, the chemotactic ligand for the Tie2 receptor. We found that CSF1 pre-treatment significantly augmented chemotaxis and that Tie2 receptor upregulation was responsible as siRNA targeting Tie2 receptor abrogated this effect. To understand any augmented angiogenic effect produced by treating these cells with CSF1, we cultured human umbilical vein endothelial cells (HUVECs with conditioned supernatants from CSF1-pre-treated CD14+ monocytes for a tube formation assay. While supernatants from CSF1-pre-treated TEMs increased HUVEC branching, a neutralizing antibody against the CSF1R abrogated this activity, as did siRNA against the Tie2 receptor. To test our hypothesis in vivo, we treated PyMT tumor-bearing mice with CSF1 and observed an expansion in the TEM population relative to total F4/80+ cells, which resulted in increased angiogenesis. Investigation into the mechanism of Tie2 receptor upregulation on CD14+ monocytes by CSF1 revealed a synergistic contribution from the PI3 kinase and HIF pathways as the PI3 kinase inhibitor LY294002, as well as HIF-1α-deficient macrophages differentiated from the bone marrow of HIF-1αfl/fl/LysMcre mice, diminished CSF1-stimulated Tie2 receptor

What type of statistical model to choose for the analysis of radioimmunoassays

International Nuclear Information System (INIS)

Huet, S.

1984-01-01

The current techniques used for statistical analysis of radioimmunoassays are not very satisfactory for either the statistician or the biologist. They are based on an attempt to make the response curve linear to avoid complicated computations. The present article shows that this practice has considerable effects (often neglected) on the statistical assumptions which must be formulated. A more strict analysis is proposed by applying the four-parameter logistic model. The advantages of this method are: the statistical assumptions formulated are based on observed data, and the model can be applied to almost all radioimmunoassays [fr

Tiešsaistes GPS izsekošanas sistēma „GPS OrientTracker”

OpenAIRE

Āboliņš, Valters

2008-01-01

Darba mērķis bija ieviest Latvijā GPS tiešsaistes izsekošanas sistēmu, kas orientēšanās sacensību laikā spētu uzrādīt, kur atrodas konkrēta persona uz doto brīdi. Tā kā Pasaulē šāda veida sistēmas jau tiek pielietotas, arī Latvijā, lai attīstītu un popularizētu orientēšanās sportu, ir nepieciešamas tiešsaistes izsekošanas sistēmas. Rezultātā tika salīdzinātas jau esošas sistēmas, to cenas, un izvēlēta piemērotākā uztvērējierīce, un beigās izstrādāta tiešsaistes izsekošanas sistēma....

Computerized statistical analysis with bootstrap method in nuclear medicine

International Nuclear Information System (INIS)

Zoccarato, O.; Sardina, M.; Zatta, G.; De Agostini, A.; Barbesti, S.; Mana, O.; Tarolo, G.L.

1988-01-01

Statistical analysis of data samples involves some hypothesis about the features of data themselves. The accuracy of these hypotheses can influence the results of statistical inference. Among the new methods of computer-aided statistical analysis, the bootstrap method appears to be one of the most powerful, thanks to its ability to reproduce many artificial samples starting from a single original sample and because it works without hypothesis about data distribution. The authors applied the bootstrap method to two typical situation of Nuclear Medicine Department. The determination of the normal range of serum ferritin, as assessed by radioimmunoassay and defined by the mean value ±2 standard deviations, starting from an experimental sample of small dimension, shows an unacceptable lower limit (ferritin plasmatic levels below zero). On the contrary, the results obtained by elaborating 5000 bootstrap samples gives ans interval of values (10.95 ng/ml - 72.87 ng/ml) corresponding to the normal ranges commonly reported. Moreover the authors applied the bootstrap method in evaluating the possible error associated with the correlation coefficient determined between left ventricular ejection fraction (LVEF) values obtained by first pass radionuclide angiocardiography with 99m Tc and 195m Au. The results obtained indicate a high degree of statistical correlation and give the range of r 2 values to be considered acceptable for this type of studies

Software for statistical data analysis used in Higgs searches

International Nuclear Information System (INIS)

Gumpert, Christian; Moneta, Lorenzo; Cranmer, Kyle; Kreiss, Sven; Verkerke, Wouter

2014-01-01

The analysis and interpretation of data collected by the Large Hadron Collider (LHC) requires advanced statistical tools in order to quantify the agreement between observation and theoretical models. RooStats is a project providing a statistical framework for data analysis with the focus on discoveries, confidence intervals and combination of different measurements in both Bayesian and frequentist approaches. It employs the RooFit data modelling language where mathematical concepts such as variables, (probability density) functions and integrals are represented as C++ objects. RooStats and RooFit rely on the persistency technology of the ROOT framework. The usage of a common data format enables the concept of digital publishing of complicated likelihood functions. The statistical tools have been developed in close collaboration with the LHC experiments to ensure their applicability to real-life use cases. Numerous physics results have been produced using the RooStats tools, with the discovery of the Higgs boson by the ATLAS and CMS experiments being certainly the most popular among them. We will discuss tools currently used by LHC experiments to set exclusion limits, to derive confidence intervals and to estimate discovery significances based on frequentist statistics and the asymptotic behaviour of likelihood functions. Furthermore, new developments in RooStats and performance optimisation necessary to cope with complex models depending on more than 1000 variables will be reviewed

PRECISE - pregabalin in addition to usual care: Statistical analysis plan

NARCIS (Netherlands)

S. Mathieson (Stephanie); L. Billot (Laurent); C. Maher (Chris); A.J. McLachlan (Andrew J.); J. Latimer (Jane); B.W. Koes (Bart); M.J. Hancock (Mark J.); I. Harris (Ian); R.O. Day (Richard O.); J. Pik (Justin); S. Jan (Stephen); C.-W.C. Lin (Chung-Wei Christine)

2016-01-01

textabstractBackground: Sciatica is a severe, disabling condition that lacks high quality evidence for effective treatment strategies. This a priori statistical analysis plan describes the methodology of analysis for the PRECISE study. Methods/design: PRECISE is a prospectively registered, double

Statistical margin to DNB safety analysis approach for LOFT

International Nuclear Information System (INIS)

Atkinson, S.A.

1982-01-01

A method was developed and used for LOFT thermal safety analysis to estimate the statistical margin to DNB for the hot rod, and to base safety analysis on desired DNB probability limits. This method is an advanced approach using response surface analysis methods, a very efficient experimental design, and a 2nd-order response surface equation with a 2nd-order error propagation analysis to define the MDNBR probability density function. Calculations for limiting transients were used in the response surface analysis thereby including transient interactions and trip uncertainties in the MDNBR probability density

Multivariate statistical analysis of atom probe tomography data

International Nuclear Information System (INIS)

Parish, Chad M.; Miller, Michael K.

2010-01-01

The application of spectrum imaging multivariate statistical analysis methods, specifically principal component analysis (PCA), to atom probe tomography (APT) data has been investigated. The mathematical method of analysis is described and the results for two example datasets are analyzed and presented. The first dataset is from the analysis of a PM 2000 Fe-Cr-Al-Ti steel containing two different ultrafine precipitate populations. PCA properly describes the matrix and precipitate phases in a simple and intuitive manner. A second APT example is from the analysis of an irradiated reactor pressure vessel steel. Fine, nm-scale Cu-enriched precipitates having a core-shell structure were identified and qualitatively described by PCA. Advantages, disadvantages, and future prospects for implementing these data analysis methodologies for APT datasets, particularly with regard to quantitative analysis, are also discussed.

Development of statistical analysis code for meteorological data (W-View)

Energy Technology Data Exchange (ETDEWEB)

Tachibana, Haruo; Sekita, Tsutomu; Yamaguchi, Takenori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2003-03-01

A computer code (W-View: Weather View) was developed to analyze the meteorological data statistically based on 'the guideline of meteorological statistics for the safety analysis of nuclear power reactor' (Nuclear Safety Commission on January 28, 1982; revised on March 29, 2001). The code gives statistical meteorological data to assess the public dose in case of normal operation and severe accident to get the license of nuclear reactor operation. This code was revised from the original code used in a large office computer code to enable a personal computer user to analyze the meteorological data simply and conveniently and to make the statistical data tables and figures of meteorology. (author)

Le Langage de Dieu: autour de la 'Révélation' et de la prophétie chez Avicenne

NARCIS (Netherlands)

Lizzini, O.L.

2018-01-01

Qu’est-ce que la prophétie? Quelle est la signification des symboles qu’elle utilise? C’est à ces questions que L’Épître sur l’établissement des prophéties répond. La prophétie y est présentée comme une nécessité. Le prophète reçoit la connaissance totale de façon immédiate et il communique au monde