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Sample records for states regional association

  1. Regional homogeneity and resting state functional connectivity: associations with exposure to early life stress.

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    Philip, Noah S; Kuras, Yuliya I; Valentine, Thomas R; Sweet, Lawrence H; Tyrka, Audrey R; Price, Lawrence H; Carpenter, Linda L

    2013-12-30

    Early life stress (ELS) confers risk for psychiatric illness. Previous literature suggests ELS is associated with decreased resting-state functional connectivity (rs-FC) in adulthood, but there are no studies of resting-state neuronal activity in this population. This study investigated whether ELS-exposed individuals demonstrate resting-state activity patterns similar to those found in PTSD. Twenty-seven adults (14 with at least moderate ELS), who were medication-free and without psychiatric or medical illness, underwent MRI scans during two 4-minute rest periods. Resting-state activity was examined using regional homogeneity (ReHo), which estimates regional activation patterns through indices of localized concordance. ReHo values were compared between groups, followed by rs-FC analyses utilizing ReHo-localized areas as seeds to identify other involved regions. Relative to controls, ELS subjects demonstrated diminished ReHo in the inferior parietal lobule (IPL) and superior temporal gyrus (STG). ReHo values were inversely correlated with ELS severity. Secondary analyses revealed decreased rs-FC between the IPL and right precuneus/posterior cingulate, left fusiform gyrus, cerebellum and caudate in ELS subjects. These findings indicate that ELS is associated with altered resting-state activity and connectivity in brain regions involved in trauma-related psychiatric disorders. Future studies are needed to evaluate whether these associations represent potential imaging biomarkers of stress exposure. Published by Elsevier Ireland Ltd.

  2. Depression and Associated Factors among Adult Inpatients at Public Hospitals of Harari Regional State, Eastern Ethiopia

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    Haile Tilahun

    2018-01-01

    Full Text Available Introduction. Globally, depression is one of the three leading causes of disease and it will be the second leading cause of world disability by 2030. The prevalence of depression in Sub-Saharan Africa ranges from 15 to 30%. In Ethiopia, depression was found to be the seventh leading cause of disease burden and its prevalence has been increased in hospital compared to community setting because hospital environment itself is stressful. Yet, no study was done in Eastern Ethiopia, where substance use like Khat is very rampant. Objective. To assess depression and associated factors among adult inpatients at public hospitals of Harari Regional State, Eastern Ethiopia, from February 01 to 28, 2017. Methodology. Hospital based cross-sectional study design was employed on 492 admitted adult patients in Harari region hospitals. Consecutive sampling method was used to include study population. The data were collected by interviewee and analyzed by SPSS version 20.0. Bivariate and multivariate logistic regression analyses were employed. p value of 0.05 or less was considered to be statistically significant. Result. A total of 489 patients were interviewed with response rate of 99.4%. Having duration of 1-2 weeks in the hospital [AOR = 2.02, 95% CI: (1.28, 3.19], being diagnosed with chronic morbidity [AOR = 4.06, 95% CI: (2.23, 7.40], being users of psychoactive drugs [AOR = 2.24, 95% CI: (1.18, 4.24], and having been admitted to surgical ward [AOR = 0.50, 95% CI: (0.31, 0.81] were significantly associated with depression. Conclusion and Recommendation. Prevalence of depression among admitted inpatients was high. Therefore, increasing the awareness of benefits of early diagnosis of patients to prevent major form of depression and strengthening the clinical set-up and establishing good referral linkage with mental health institutions was considered to be cost-effective method to reduce its prevalence.

  3. Altered regional and circuit resting-state activity associated with unilateral hearing loss.

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    Xingchao Wang

    Full Text Available The deprivation of sensory input after hearing damage results in functional reorganization of the brain including cross-modal plasticity in the sensory cortex and changes in cognitive processing. However, it remains unclear whether partial deprivation from unilateral auditory loss (UHL would similarly affect the neural circuitry of cognitive processes in addition to the functional organization of sensory cortex. Here, we used resting-state functional magnetic resonance imaging to investigate intrinsic activity in 34 participants with UHL from acoustic neuroma in comparison with 22 matched normal controls. In sensory regions, we found decreased regional homogeneity (ReHo in the bilateral calcarine cortices in UHL. However, there was an increase of ReHo in the right anterior insular cortex (rAI, the key node of cognitive control network (CCN and multimodal sensory integration, as well as in the left parahippocampal cortex (lPHC, a key node in the default mode network (DMN. Moreover, seed-based resting-state functional connectivity analysis showed an enhanced relationship between rAI and several key regions of the DMN. Meanwhile, lPHC showed more negative relationship with components in the CCN and greater positive relationship in the DMN. Such reorganizations of functional connectivity within the DMN and between the DMN and CCN were confirmed by a graph theory analysis. These results suggest that unilateral sensory input damage not only alters the activity of the sensory areas but also reshapes the regional and circuit functional organization of the cognitive control network.

  4. Resting-state functional connectivity of ventral parietal regions associated with attention reorienting and episodic recollection

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    Sander M Daselaar

    2013-02-01

    Full Text Available In functional neuroimaging studies, ventral parietal cortex (VPC is recruited by very different cognitive tasks. Explaining the contributions VPC to these tasks has become a topic of intense study and lively debate. Perception studies frequently find VPC activations during tasks involving attention-reorienting, and memory studies frequently find them during tasks involving episodic recollection. According to the Attention to Memory (AtoM model, both phenomena can be explained by the same VPC function: bottom-up attention. Yet, a recent functional MRI (fMRI meta-analysis suggested that attention-reorienting activations are more frequent in anterior VPC, whereas recollection activations are more frequent in posterior VPC. Also, there is evidence that anterior and posterior VPC regions have different functional connectivity patterns. To investigate these issues, we conducted a resting-state functional connectivity analysis using as seeds the center-of-mass of attention-reorienting and recollection activations in the meta-analysis, which were located in the supramarginal gyrus (SMG, around the temporo-parietal junction—TPJ and in the angular gyrus (AG, respectively. The SMG seed showed stronger connectivity with ventrolateral prefrontal cortex (VLPFC and occipito-temporal cortex, whereas the AG seed showed stronger connectivity with the hippocampus and default network regions. To investigate whether these connectivity differences were graded or sharp, VLPFC and hippocampal connectivity was measured in VPC regions traversing through the SMG and AG seeds. The results showed a graded pattern: VLPFC connectivity gradually decreases from SMG to AG, whereas hippocampal connectivity gradually increases from SMG to AG. Importantly, both gradients showed an abrupt break when extended beyond VPC borders. This finding suggests that functional differences between SMG and AG are more subtle than previously thought. These connectivity differences can be

  5. Associations of resting-state fMRI functional connectivity with flow-BOLD coupling and regional vasculature.

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    Tak, Sungho; Polimeni, Jonathan R; Wang, Danny J J; Yan, Lirong; Chen, J Jean

    2015-04-01

    There has been tremendous interest in applying functional magnetic resonance imaging-based resting-state functional connectivity (rs-fcMRI) measurements to the study of brain function. However, a lack of understanding of the physiological mechanisms of rs-fcMRI limits their ability to interpret rs-fcMRI findings. In this work, the authors examine the regional associations between rs-fcMRI estimates and dynamic coupling between the blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF), as well as resting macrovascular volume. Resting-state BOLD and CBF data were simultaneously acquired using a dual-echo pseudocontinuous arterial spin labeling (pCASL) technique, whereas macrovascular volume fraction was estimated using time-of-flight MR angiography. Functional connectivity within well-known functional networks—including the default mode, frontoparietal, and primary sensory-motor networks—was calculated using a conventional seed-based correlation approach. They found the functional connectivity strength to be significantly correlated with the regional increase in CBF-BOLD coupling strength and inversely proportional to macrovascular volume fraction. These relationships were consistently observed within all functional networks considered. Their findings suggest that highly connected networks observed using rs-fcMRI are not likely to be mediated by common vascular drainage linking distal cortical areas. Instead, high BOLD functional connectivity is more likely to reflect tighter neurovascular connections, attributable to neuronal pathways.

  6. Substance use and associated factors among preparatory school students in Bale Zone, Oromia Regional State, Southeast Ethiopia.

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    Dida, Nagasa; Kassa, Yibeltal; Sirak, Teshome; Zerga, Ephrem; Dessalegn, Tariku

    2014-08-09

    The use of cigarettes, alcohol, khat, and other substances is a worldwide threat which especially affects young people and which is also common among the youth of Ethiopia. However, its prevalence and associated factors have not been addressed well yet. Thus, this study aimed to assess the prevalence and associated factors of substance use among preparatory school students in Bale Zone, Oromia Regional State, Southeast Ethiopia. An institutional-based cross-sectional study was conducted among 603 randomly selected students from five of eight preparatory schools of Bale Zone, Oromia Regional State, Southeast Ethiopia, in March 2013. The sample size was calculated by a single population proportion formula and allocated proportionally for the schools based on the number of students. A pretested structured questionnaire was used to collect the data. The data were analyzed using SPSS version 16.0. Descriptive, bivariate, and multivariate logistic regressions were employed to identify the predictors of substance use. The overall current prevalence of substance use among the respondents was 34.8% (210). Specifically, 23.6% (102) and 4.6% (28) of the respondents chewed khat and smoked cigarette, respectively. Sex, age, and substance use status of the respondents' father, mother, siblings, and best friend had an association with substance use. Male respondents were about ten times more at risk of practicing substance use compared to female respondents [adjusted odds ratio (AOR) 11.37, 95% confidence interval (CI) 4.42-29.23]. Respondents whose sibling(s) smokes cigarette were four times more likely to use substance (AOR 4.44, 95% CI 1.11-17.79). Respondents whose best friend chews khat were 11 times more likely to use substance when compared with those whose best friend does not practice the given factor (AOR 11.15, 95% CI 4.43-28.07). Respondents whose family uses one or more substances were more likely use substance(s). Respondents whose best friend uses substance(s) were

  7. Management of environmental risks associated with landfills in seismically active regions in the New Independent States of Central Asia

    International Nuclear Information System (INIS)

    Webb, S.M.

    2009-01-01

    Sustainable waste management and disposal is a societal challenge in terms of economics, public health and environmental impact. The situation in developing countries, and in particular those subject to extreme natural hazards, results in increased overall risk as governments prioritize investments to issues of perceived higher economic importance. This dissertation investigates environmental risks associated with landfills in seismically active regions in the New Independent States of Central Asia. Environmental risk from municipal solid waste landfill sites encompasses a wide range of topics within socio-economics, physical sciences and engineering and therefore necessitates a multi-disciplinary approach. The underlying study is an accumulative result of a three-year collaborative research project (Contract No. INCO-CT-2005-516732) funded within the Eu Sixth Framework Programme (FP6). The international cooperation involved European, Russian and Central Asian research partners forming a multi-disciplinary consortium covering: GIS technologies, geology / hydrogeology geophysics and geotechnical engineering; landfill design and operation and waste management. understanding the relevant socio-economic aspects and legislative frameworks was necessary to prepare results and recommendations to address stakeholders in the Central Asian countries: Kazakhstan, Kyrgyzstan,Tajikistan,Turkmenistan and uzbekistan. (author) [de

  8. Factors associated with unintentional injury among the paediatric age population in the hospitals of Amhara National Regional State, Ethiopia

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    Bewket Tadesse Tiruneh

    Full Text Available Background: Childhood unintentional injuries cause nearly 875,000 deaths each year. The aim of this study was to assess the prevalence and factors associated with unintentional injury of children presenting to the hospitals of Amhara Regional State, Ethiopia. Methods: In a hospital-based, cross-sectional study undertaken in one month, from April 1 to 30th 2016, 893 children less than 18 years of age were included. Data were collected using an interviewer-administered questionnaire. Training was given to all data collectors and supervisors. Data was entered into EPI info version 7 and then exported to SPSS version 20, for further analysis. Results: Unintentional injury caused 62% (554 of all injuries in attending children. Several factors affected the likelihood of injuries, namely the age of the child, age of the parents or guardians, sex of the child, and whether the child lived with the parents. Modifiable factors were the child’s behaviour, awareness of danger, the child’s level of educational, if the child’s parent had received adequate injury counselling, and whether a child was left in the care of another child. The source of light in the house, and house floor material were also significant factors at p < 0.05. Conclusion: The prevalence of unintentional injury was high. Many of the factors associated with injuries are modifiable and safety issues for children need urgent attention. Keywords: Unintentional injury, Paediatric, Ethiopia, Low resource

  9. Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner.

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    Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Makoto Miyauchi, Carlos; Shinada, Takamitsu; Sakaki, Kohei; Nozawa, Takayuki; Ikeda, Shigeyuki; Yokota, Susumu; Daniele, Magistro; Sassa, Yuko; Kawashima, Ryuta

    2017-05-15

    Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Healthcare Associated Infections - State

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    U.S. Department of Health & Human Services — The Healthcare-Associated Infections (HAI) measures - state data. These measures are developed by Centers for Disease Control and Prevention (CDC) and collected...

  11. [Fruit flies (Diptera: Tephritidae) and their parasitoids (Hymenoptera: Braconidae) associated to host plants in the southern region of Bahia State].

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    Bittencourt, M A L; da Silva, A C M; Silva, V E S; Bomfim, Z V; Guimarães, J A; de Souza Filho, M F; Araujo, E L

    2011-01-01

    The association among Anastrepha species, braconid parasitoids and host fruits in southern Bahia is recorded. Doryctobracon areolatus (Szépligeti) was associated with A. serpentina (Wied.) in Pouteria caimito, A. bahiensis Lima in Helicostylis tomentosa, A. sororcula Zucchi in Eugenia uniflora, and A. obliqua (Macquart) in Spondias purpurea. Anatrepha obliqua was unique in fruits of Averrhoa carambola, but associated with D. areolatus, Asobara anastrephae (Muesebeck) and Utetes anastrephae (Viereck). In Achras sapota, A. serpentina was associated with A. anastrephae and D. areolatus, while in Psidium guajava, A. fraterculus (Wied.) and A. sororcula were associated with D. areolatus and U. anastrephae.

  12. Vaccination Coverage and Associated Factors among Children Aged 12–23 Months in Debre Markos Town, Amhara Regional State, Ethiopia

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    Tenaw Gualu

    2017-01-01

    Full Text Available Introduction. Vaccination is the administration of a vaccine or a biological substance intended to stimulate a recipient’s immune system to produce antibodies or undergo other changes that provide future protection against specific infectious diseases. Objective. To determine vaccination coverage and associated factors among children aged 12–23 months in Debre Markos town 2016. Methods. Community-based cross-sectional study was employed among 288 mothers/caretakers to child (12–23 months pair. Study populations were selected using systematic random sampling technique. Structured interviewer administered questionnaires were used to collect data. Variables with P value of less than 0.05 in multivariate analysis were considered as statistically significant at 95% CI. Result. About 264 (91.7% of children were completely vaccinated. Male birth 3.24 (1.16–9.04, wanted pregnancy 2.89 (1.17–7.17, having at least two ANC follow-ups 4.04 (1.35–12.06, and short distance from vaccination site 3.38 (1.29–8.86 were found positively associated with complete immunization. Conclusion and Recommendation. There was relatively high immunization coverage in the study. Child’s sex, ANC follow-up, type of pregnancy, and distance from health institution were factors associated with complete vaccination. Preventing unwanted pregnancy and promoting ANC and postnatal follow-up should be strengthened. Vaccination sites should also be further expanded.

  13. Prevalence and risk factors associated with goat gastrointestinal helminthiasis in the Sertão region of Paraíba State, Brazil.

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    Vieira, Vanessa Diniz; Feitosa, Thais Ferreira; Vilela, Vinícius Longo Ribeiro; Azevedo, Sérgio Santos; de Almeida Neto, João Leite; de Morais, Dayana Firmino; Ribeiro, Ana Raquel Carneiro; Athayde, Ana Célia Rodrigues

    2014-02-01

    Gastrointestinal helminthiasis represents an obstacle to goat raising, causing severe damage to herds such as growth retardation, weight loss, and even death. In this study, we aimed to determine the prevalence and risk factors associated to goat gastrointestinal helminthiasis in the Sertão region of Paraíba State, Brazil. A total of 256 goats from 54 farms were systematically sampled. Blood and fecal samples were collected from each animal for egg per gram (EPG), larval culture, and packed cell volume (PCV) analyses. We found that 79.3% of the goats investigated were parasitized with gastrointestinal helminths. Significant correlation (p = 0.004) was observed between the EPG and PCV of the animals studied, and it was observed that the EPG increases as the PCV decreases. In the larval culture, the most prevalent helminth was Haemonchus sp. (83.2%). Age and sex were significant variables (p ≤ 0.20) for the development of gastrointestinal helminths: 86.8% of animals over 36 months of age and 81.7% of females were infected. The variable type of animal exploitation was also significant, with 90.3% (p ≤ 0.20) of the animals presenting double suitability (milk and meat). The Sertão region of Paraíba State presents high prevalence of gastrointestinal helminthiasis in goats, and age and type of animal exploitation are the most relevant risk factors to the development of these parasites.

  14. Environmental Finance Center Serving EPA's Region 8 States

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    The National Rural Water Association, headquartered in Duncan Oklahoma, has been selected through a competitive grants process to establish a regional Environmental Finance Center (EFC) serving EPA Region 8 states.

  15. Increasing state market share through regional positioning

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    Muzaffer Uysal; Joseph S. Chen; Daniel R. Williams

    2000-01-01

    State tourism officials need to know more about the nature of in-state and out-of-state visitor characteristics and how actual and potential visitors perceive local destinations. The main objective of this study was to understand Virginia's image as a travel destination versus competitive states in the Mid-Atlantic region of the USA. The regional competitiveness...

  16. Abnormal regional spontaneous neuronal activity associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder revealed by resting-state functional MRI.

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    Qiu, Linlin; Fu, Xiangshuai; Wang, Shuai; Tang, Qunfeng; Chen, Xingui; Cheng, Lin; Zhang, Fuquan; Zhou, Zhenhe; Tian, Lin

    2017-02-15

    A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD. Thirty-one patients with OCD and 32 age-and sex-matched normal controls received the fMRI scans and fractional amplitude of low-frequency fluctuation (fALFF) approach was applied to identify the abnormal brain activity. We found that patients with OCD showed decreased fALFF not only in the cortical-striato-thalamo-cortical (CSTC) circuits like the thalamus, but also in other cerebral systems like the cerebellum, the parietal cortex and the temporal cortex. Additionally, OCD patients demonstrated significant associations between decreased fALFF and obsessive-compulsive symptom severity in the thalamus, the paracentral lobule and the cerebellum. Our results provide evidence for abnormal spontaneous neuronal activity in distributed cerebral areas and support the notion that brain areas outside the CSTC circuits may also play an important role in the pathophysiology of OCD. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Job Satisfaction and Associated Factors among Anesthetists Working in Amhara National Regional State, Northwest Ethiopia, May 2017: A Multicenter Cross-Sectional Study

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    Demeke Yilkal Fentie

    2018-01-01

    Full Text Available Background. Job satisfaction is an important determinant of health staff’s motivation, retention, and performance. Difficulties in critical decision-making and problems with lack of respect and recognition lead to lower job satisfaction level among anesthetists. It leads to high turnover intention, dropout from the profession, burnout, impaired health status of anesthetists, and lower work performance. Objective. The aim of this multicenter cross-sectional study was to assess the level of job satisfaction and associated factors among anesthetists working in Amhara National Regional State. Methods. A multicenter cross-sectional study was conducted from April 1 to June 30, 2017. Ninety-eight anesthetists that were working in Amhara National Regional State Hospitals were involved in this study. The structured questionnaire was scored on five-point Likert scales. Data were analyzed using Statistical Package for Social Sciences version 20. Binary logistic regression was used to measure statistical significance between dependent and each independent variable. Variables with P value of ≤0.2 on crude analysis were taken into multivariate analysis, and P value 0.05 and 95% CI was used as cut off point. Result. 98 out of 104 participants were involved in this study with a response rate of 94.3%. The overall level of job satisfaction was 46.9%. Anesthetists in academic working position were satisfied with the odds of about 2.3 (AOR = 2.269; CI = 1.137–6.740 compared to those in clinical working position. Anesthetists were least satisfied with coworker relationships (37.8%, work schedule (43.9%, professional opportunity (46.9%, and recognition (49% while they were most satisfied from their control of responsibility (59.2%, social interaction (55%, and salary and benefits (51%. Conclusion and Recommendation. Job satisfaction of anesthetists was low, and we suggest that facilitation of professional development, creation of smooth relationship in

  18. Risk Factors Associated with Triatomines and Its Infection with Trypanosoma cruzi in Rural Communities from the Southern Region of the State of Mexico, Mexico

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    Medina-Torres, Imelda; Vázquez-Chagoyán, Juan C.; Rodríguez-Vivas, Roger I.; de Oca-Jiménez, Roberto Montes

    2010-01-01

    Trypanosoma cruzi prevalence in triatomines and risk factors associated to the presence of the insect were studied in 990 rural houses in the southern region of the State of Mexico, Mexico. In each house, triatomines were collected, and information related to house construction material was obtained. T. cruzi infection was diagnosed in all triatomines. A primary screening was performed using 2 × 2 contingency tables of exposure variables. All variables with P ≤ 0.20 were analyzed by logistic regression. Triatomines (N = 125) were collected from 822 houses and analyzed for T. cruzi infection. Triatoma pallidipennis (97.4%) and Triatoma dimidiata (2.6%) were identified in 52.1% of the localities and in 6.1% of the houses. Infection was found in 28.0% of triatomines, from which 28.9% were nymphs. Factors associated with triatomine infestation were flooring construction material (dirt floor: odds ratio [OR], 10.05; 95% confidence interval [CI], 5.31–18.04; P = 0.0001), house rooms (at least three rooms: OR, 2.04; 95% CI, 1.07–3.86; P = 0.028), and ceiling construction material (cardboard lamina tile: OR, 6.84; 95% CI, 1.49–31.31; P = 0.013). This study shows T. cruzi circulation in triatomines in the area of study, and because triatomines are adapted for living and reproducing in the domestic environment, there is a potential risk of Chagas disease transmission to humans. Also, we can conclude that the construction materials and house inhabitants are risk factors of triatomines infestation. PMID:20064995

  19. Timely initiation of breastfeeding and associated factors among mothers in Motta town, East Gojjam zone, Amhara regional state, Ethiopia, 2015: a cross-sectional study.

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    Tewabe, Tilahun

    2016-10-19

    Timely initiation of breastfeeding within one hour after birth and exclusive breastfeeding is recommended for the first six months of infant life along with continuation of breastfeeding up to two years. Timely initiation of breastfeeding has the potential to prevent 22 % of neonatal deaths. The objective of this study was to assess timely initiation of breastfeeding and associated factors among mothers who have infants less than six months of age in Motta town, East Gojjam, Amhara Regional State, Ethiopia. Community based quantitative cross-sectional study was conducted from April 7, 2015 to May 7, 2015. Simple random sampling technique was applied after taking all registered mothers who have infants less than 6 months old from local health extension workers of each kebele. A total of 423 mothers with infant less than six month old were included in this study. The data was collected from all four Kebeles using interviewer administered questionnaire. Descriptive and inferential statistics were used to present the data. Both bivariate and multivariate logistic regression analyses were used to identify factors associated with timely initiation breastfeeding. Prevalence of timely initiation of breastfeeding was78.8 % [95 % CL: 74.88 %, 82.72 %]. Mothers who gave birth to their infant in a health institution [AOR = 3.486(1.253, 9.700)], birthed vaginally [AOR = 5.722(3.134, 11.246)] and didn't give prelacteal food [AOR = 4.627(2.095, 10.220)] were more likely to initiate breastfeeding early than their counterparts. Prevalence of timely initiation of breastfeeding in the study area was 78.8 %. Place of delivery, mode of delivery and prelactal feeding were the independent predictors of timely initiation of breastfeeding. Recommendations to increase timely initiation of breastfeeding were: encouraging mothers to deliver their child in a health institution, minimizing caesarean delivery as much as possible and educating mothers and community as a whole

  20. Regionalisms, Nationalisms, and the Canadian State.

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    Knight, David B.

    1984-01-01

    Concentrating on events in Canada during the last ten years, this article discusses the Quebec separatist movement and other strong regionalisms in Canada. Important processes involved with conflict and compromise within the Canadian state are examined. (RM)

  1. Household Food Insecurity, Underweight Status, and Associated Characteristics among Women of Reproductive Age Group in Assayita District, Afar Regional State, Ethiopia.

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    Abdu, Jemal; Kahssay, Molla; Gebremedhin, Merhawi

    2018-01-01

    Poor nutritional status of women has been a serious problem in Ethiopia. Rural women are more likely to be undernourished than urban women. Afar region is the most likely to be undernourished (43.5%). Despite the humanitarian and food aid, food insecurity and maternal underweight are very high in the region. Household food insecurity is not adequately studied in Afar region. The aim of this study was to assess the prevalence of household food insecurity and underweight status and its association among reproductive age women. The study was conducted in Assayita district in June 2015. Community-based cross-sectional study design was used among nonpregnant women. Household data was collected using structured questionnaire. Multistage cluster sampling procedure was applied. Two pastoral and two agropastoral Kebeles have been selected by simple random sampling. Systematic random sampling was used to select respondents. The total sample size was 549 households. Household Food Insecurity Access Scale (HFIAS) and anthropometric data were used to determine food insecurity and underweight, respectively. Multivariate regression models were used to measure associations. Prevalence of HFIAS was 70.4 with a mean of 7.0 (3.6 ± SD); 26.1%, 30.20%, and 14.1% were mild, moderate, and severe food insecurity, respectively. Underweight prevalence (BMI 2 children below five years of age were statistically associated with household food insecurity and maternal underweight. Household food insecurity and maternal underweight were very high. Age, parity, and having ≥2 children below five years of age were associated with household food insecurity. Maternal underweight was associated with maternal age, marital status, parity, number of children below 5 years, household food insecurity, and vocation of the respondents.

  2. American Association Of State Climatologists

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records documenting the business, membership, and meetings of the American Association of State Climatologists, from 1976-92. Material donated in 2008 by the estate...

  3. Geology of the Curimatau medium region (Paraiba State, Brazil) and the emplacement of the Dona Ines granite associated to the Brasiliano transcurrent shear zones

    International Nuclear Information System (INIS)

    Borges, Sergio Vieira Freire

    1996-01-01

    In an area of about 700 Km 2 located in the northeast of Paraiba State and having as main point the town of Dona Ines, a geologic/structural mapping, a gravimetric survey and radiometric dating using the Rb/Sr method in whole rock and Sm.Nd model ages were undertaken in order to study and to understand the geology of this portion of terrain, the emplacement of the Dona Ines granitoids and its relationship with the enclosing rocks and the deformation acting at the time of the intrusion. The age of the pluton of Dona Ines was determined by the Rb/Sr whole rock method as 560 ± 20 Ma (end of Brasiliano Cycle in the region). Sm.Nd model ages in granitoids of Araras, Belem and Dona Ines have revealed paleoproterozoic ages for their crustal sources, as indicated by the negative ε nd of this rock

  4. Economic disparities between EU states and regions

    Directory of Open Access Journals (Sweden)

    Ion CIUREA

    2010-05-01

    Full Text Available EU has 27 Member States representing a community and a market of 493million citizens, which creates further economic and social disparities between thestates and their 271 regions. In a region in four, the GDP (gross domestic product percapita is 75% below the average for the EU-27. Based on the concepts of solidarity andcohesion, regional policy of the European Union favors reducing structural disparitiesbetween EU regions, the balanced development of the community and promoting aneffective equality of opportunity between people. Over the past 50 years, Europeancooperation has helped build highways, sewage plants, bridges, laboratories forbiotechnology. She helped to revive urban areas and neglected activities, throughcountless projects in the poorest regions of the Union.. Two key values: solidarity andcohesion, underlying these projects and the regional policy of the European Union. Theeconomic, social and territorial cohesion will always be at the heart of Europe Strategy2020, a key mechanism for achieving the priorities for a smart growth, sustainable andinclusive in the Member States and regions.

  5. Regional homogeneity associated with overgeneral autobiographical memory of first-episode treatment-naive patients with major depressive disorder in the orbitofrontal cortex: A resting-state fMRI study.

    Science.gov (United States)

    Liu, Yansong; Zhao, Xudong; Cheng, Zaohuo; Zhang, Fuquan; Chang, Jun; Wang, Haosen; Xie, Rukui; Wang, Zhiqiang; Cao, Leiming; Wang, Guoqiang

    2017-02-01

    Overgeneral autobiographical memory (OGM) is involved in the onset and maintenance of depression. Recent studies have shown correlations between OGM and alterations of some brain regions by using task-state functional magnetic resonance imaging (fMRI). However, the correlation between OGM and spontaneous brain activity in depression remains unclear. The purpose of this study was to determine whether patients with major depressive disorder (MDD) show abnormal regional homogeneity (ReHo) and, if so, whether the brain areas with abnormal ReHo are associated with OGM. Twenty five patients with MDD and 25 age-matched, sex-matched, and education-matched healthy controls underwent resting-state fMRI. All participants were also assessed by 17-item Hamilton Depression Rating Scale and autobiographical memory test. The ReHo method was used to analyze regional synchronization of spontaneous neuronal activity. Patients with MDD, compared to healthy controls, exhibited extensive ReHo abnormalities in some brain regions, including the frontal, temporal, and occipital cortex. Moreover, ReHo value of the orbitofrontal cortex was negatively correlated with OGM scores in patients with MDD. The sample size of this study was relatively small, and the influence of physiological noise was not completely excluded. These results suggest that abnormal ReHo of spontaneous brain activity in the orbitofrontal cortex may be involved in the pathophysiology of OGM in patients with MDD. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. New Insights on US Aggregate and State Level Trade with the China Region%New Insights on US Aggregate and State Level Trade with the China Region

    Institute of Scientific and Technical Information of China (English)

    Catherine Y. Co

    2011-01-01

    Aggregate trade data with breakdown into related and non-related party components show that US multinational enterprises use different trading strategies in the China region relative to other countries. US trade with the China region in 2002-007 is characterized by arm 's- length transactions. State-level trade data show great variability in state engagement with the region through trade: exports to the region range from 1 to 28 percent of state exports. In addition, compared to exports to other countries, exports to the region are highly concentrated. At the extreme, for some states, 96-98 percent of exports to the region are computer and electronic products. Finally, gravity regressions show that state exports to Hong Kong are posflively associated with the relative size of the ltong Kong-born population in the states. There is no evidence that stricter labor regimes lead to lower state exports.

  7. Dipterofauna Associated with Sus scrofa Linné, 1758, Carcasses in Urban and Coastal Regions of São Paulo State, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Luiza Cavallari

    2015-01-01

    Full Text Available Cadaverous entomofauna successions vary according to the region, environment, and climate, and such differences may occur within the same country due to seasonal variations. The present study aimed to analyze and compare the dipterofauna that visit or colonize carcasses in the urban and coastal areas of São Paulo, Brazil, during summer and winter seasons. Four swine (Sus scrofa Linné, 1758 carcasses of approximately 12 kg were used. The animals were previously euthanized and then placed in metal cages covered with a flight intercept trap (Shannon, modified. In total, 10,495 flies from 39 families were collected, with 15 species belonging to the Calliphoridae family, 14 species belonging to the Fanniidae family, 43 species belonging to the Muscidae family, and 22 species belonging to the Sarcophagidae family. Flies from these four families visited all carcasses; however, they did not show the highest visitation frequencies in all of the trials. Species variations occurred between the experiments that were performed at different locations and in different seasons. Furthermore, difference in the number of insects attracted to each stage of decomposition was observed. In addition to the four families highlighted above, the families Phoridae, Sepsidae, Otitidae, and Piophilidae were observed in all carcasses.

  8. Menstrual problems and associated factors among students of Bahir Dar University, Amhara National Regional State, Ethiopia: A cross-sectional survey.

    Science.gov (United States)

    Shiferaw, Muluken Teshome; Wubshet, Mamo; Tegabu, Desalegn

    2014-01-01

    Menstrual problems are the most common gynecologic complaints. The prevalence is highest in the 20 to 24-year-old age group and decreases progressively thereafter. They affect not only the woman, but also family, social and national economics as well. However, Population studies on Menstrual problems and associated factors were very little for university students in Ethiopia. Institutional based quantitative cross-sectional study was employed at Bahir Dar University from October 14 to 20, 2010, Ethiopia. Stratified sampling technique was used and 491 study subjects were randomly selected from faculties. Only 470 respondents had given complete response for the self-administered questionnaire and were included in the final analysis. Data was entered and analyzed with SPSS version 16.0 windows. The main statistical method applied was logistic regression (unconditional) and both the classical bivariate and the multivariate analyses were considered. The prevalence of dysmenorrhea and premenstrual syndrome were 85.1% and 72.8%, respectively. The most contributing factors remained to be statistically significant and independently associated with dysmenorrhea were having menstrual cycle length of 21-35 days (AOR=0.16, 95%CI: 0.04, 0.71), family history of dysmenorrhea (AOR=3.80, 95%CI: 2.13, 6.78) and circumcision (AOR=1.84, 95%CI: 1.001, 3.386) while with premenstrual syndrome were educational status of mothers being certified in certificate and beyond (AOR=0.45, 95%CI: 0.25, 0.83), living in Peda campus (AOR=2.11, 95%: 1.30, 3.45), having irregular menstruation (AOR=1.87, 95%CI: 1.17, 2.99) and family history of premenstrual syndrome (AOR=4.19, 95%CI: 2.60, 6.74). The prevalence of menstrual problems among students of Bahir Dar University was very high. Menstrual cycle length, family history of dysmenorrhea and circumcision were the most contributing factors associated with dysmenorrhea while educational status of mothers, regularity of menstruation, and family history

  9. The prevalence of malnutrition and its associated risk factors among women of reproductive age in Ziway Dugda district, Arsi Zone, Oromia Regional State, Ethiopia.

    Science.gov (United States)

    Ferede, Abebe; Lemessa, Firaol; Tafa, Mesfin; Sisay, Solomon

    2017-11-01

    Adequate nutrition is an important factor to determine the health and well-being of women, children and society as a whole. Although various nutritional policies were formulated and aimed at reducing malnutrition at the global level, the magnitude of malnutrition (body mass index [BMI] malnutrition and to identify the associated risk factors among women of reproductive age. A cross-sectional study was conducted in Ziway Dugda district in Ethiopia among 430 women of reproductive age between September 20 and November 21, 2015. A systematic sampling method was used to select the study participants. Descriptive statistics and logistic regression were used to determine the prevalence of malnutrition and to identify associated independent risk factors such as women's age, housing conditions, drinking water sources, habits of hand washing, dietary intake and food insecurity. The mean values of weight, height and BMI of the study participants were 51 kg, 157 cm and 18.1 kg/m 2 , respectively. Prevalence of malnutrition (BMI malnutrition among women of the same age group compared to women from food secured households. A high prevalence of malnutrition (48.6%) was observed among women of reproductive age. Although nutrient-rich foods were available, their consumption appears insufficient. Hence, it is strongly recommended to have behavioural change communication for enhancing adequate intake of a diversified diet and to promote environmental and hygienic conditions of women through improving their socio-economic status. Copyright © 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  10. Regional vulnerability of longitudinal cortical association connectivity

    Directory of Open Access Journals (Sweden)

    Rafael Ceschin

    2015-01-01

    Full Text Available Preterm born children with spastic diplegia type of cerebral palsy and white matter injury or periventricular leukomalacia (PVL, are known to have motor, visual and cognitive impairments. Most diffusion tensor imaging (DTI studies performed in this group have demonstrated widespread abnormalities using averaged deterministic tractography and voxel-based DTI measurements. Little is known about structural network correlates of white matter topography and reorganization in preterm cerebral palsy, despite the availability of new therapies and the need for brain imaging biomarkers. Here, we combined novel post-processing methodology of probabilistic tractography data in this preterm cohort to improve spatial and regional delineation of longitudinal cortical association tract abnormalities using an along-tract approach, and compared these data to structural DTI cortical network topology analysis. DTI images were acquired on 16 preterm children with cerebral palsy (mean age 5.6 ± 4 and 75 healthy controls (mean age 5.7 ± 3.4. Despite mean tract analysis, Tract-Based Spatial Statistics (TBSS and voxel-based morphometry (VBM demonstrating diffusely reduced fractional anisotropy (FA reduction in all white matter tracts, the along-tract analysis improved the detection of regional tract vulnerability. The along-tract map-structural network topology correlates revealed two associations: (1 reduced regional posterior–anterior gradient in FA of the longitudinal visual cortical association tracts (inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, optic radiation, posterior thalamic radiation correlated with reduced posterior–anterior gradient of intra-regional (nodal efficiency metrics with relative sparing of frontal and temporal regions; and (2 reduced regional FA within frontal–thalamic–striatal white matter pathways (anterior limb/anterior thalamic radiation, superior longitudinal fasciculus and cortical spinal tract

  11. Magnitude of institutional delivery service utilization and associated factors among women in pastoral community of Awash Fentale district Afar Regional State, Ethiopia.

    Science.gov (United States)

    Assefa, Luelseged; Alemayehu, Mussie; Debie, Ayal

    2018-03-02

    Reduction of maternal mortality is a global priority particularly in developing countries like Ethiopia where maternal mortality ratio is one of the highest in the world. Most deliveries in developing countries occur at home without skilled birth attendants. Therefore, the objective of this study was to assess institutional delivery service utilization and associated factors among women in pastoral community of Awash Fentale district, Ethiopia. Overall, 35.2% of women delivered at health facilities. Women who had good knowledge AOR = 2.1, 95% CI 1.32, 4.87), Ante Natal Care (ANC) follow up (AOR = 3.2, 95% CI 1.55, 6.63), resided in a place where distance to reach at the nearby health facilities takes delivery place (AOR = 1.9; 95% CI 1.49, 5.07) were more likely to deliver at health facility. Therefore, strengthening ANC services, improving maternal knowledge, involving husbands in decision of delivery place and expanding health facilities in the community would enhance institutional delivery.

  12. 78 FR 48326 - Partial Disapproval of State Implementation Plan; Arizona; Regional Haze Requirements

    Science.gov (United States)

    2013-08-08

    ... Disapproval of State Implementation Plan; Arizona; Regional Haze Requirements AGENCY: Environmental Protection... behalf of National Parks Conservation Association, Sierra Club, Physicians for Social Responsibility... Haze State Implementation Plan Revision submitted by the Arizona Department of Environmental Quality on...

  13. Regional geologic framework off northeastern United States

    International Nuclear Information System (INIS)

    Schlee, J.; Behrendt, J.C.; Grow, J.A.; Robb, J.M.; Mattick, R.E.; Taylor, P.T.; Lawson, B.J.

    1976-01-01

    Six multichannel seismic-reflection profiles taken across the Atlantic continental margin off the northeastern United States show an excess of 14 km of presumed Mesozoic and younger sedimentary rocks in the Baltimore Canyon trough and 8 km in the Georges Bank basin. Beneath the continental rise, the sedimentary prism thickness exceeds 7 km south of New Jersey and Maryland, and it is 4.5 km thick south of Georges Bank Stratigraphically, the continental slope--outer edge of the continental shelf is a transition zone of high-velocity sedimentary rock, probably carbonate, that covers deeply subsidized basement. The spatial separation of magnetic and gravity anomalies on line 2 (New Jersey) suggests that in the Baltimore Canyon region the magnetic-slope anomaly is due to edge effects and that the previously reported free-air and isostatic gravity anomalies over the outer shelf may be due in part to a lateral increase in sediment density (velocity) near the shelf edge. The East Coast magnetic anomaly and the free-air gravity high both coincide over the outer shelf edge on line 1 (Georges Bank) but are offset by 20 km from the ridge on the reflection profile

  14. Cumulative Environmental Management Association : Wood Buffalo Region

    International Nuclear Information System (INIS)

    Friesen, B.

    2001-01-01

    The recently announced oil sands development of the Wood Buffalo Region in Alberta was the focus of this power point presentation. Both mining and in situ development is expected to total $26 billion and 2.6 million barrels per day of bitumen production. This paper described the economic, social and environmental challenges facing the resource development of this region. In addition to the proposed oil sands projects, this region will accommodate the needs of conventional oil and gas production, forestry, building of pipelines and power lines, municipal development, recreation, tourism, mining exploration and open cast mining. The Cumulative Environmental Management Association (CEMA) was inaugurated as a non-profit association in April 2000, and includes 41 members from all sectors. Its major role is to ensure a sustainable ecosystem and to avoid any cumulative impacts on wildlife. Other work underway includes the study of soil and plant species diversity, and the effects of air emissions on human health, wildlife and vegetation. The bioaccumulation of heavy metals and their impacts on surface water and fish is also under consideration to ensure the quality and quantity of surface water and ground water. 3 figs

  15. Functional groups of entomofauna associated to aquatic macrophytes in Correntoso river, Rio Negro sub-region, Pantanal, Mato Grosso do Sul State, Brazil - doi: 10.4025/actascibiolsci.v34i1.7822

    Directory of Open Access Journals (Sweden)

    José Sabino

    2011-11-01

    Full Text Available This work aimed to study the structure of functional groups of entomofauna associated to aquatic macrophytes in Correntoso river, Rio Negro sub-region, Pantanal, Mato Grosso do Sul State, Brazil. Six samples were taken in different seasonal periods; ebb, dry and wet. The organisms were collected using D net (300 m mesh, sweeping five times through the roots of macrophyte banks at each sample session. Three environments were compared (open, intermediary, close using data from six collection sites, through which were analyzed absolute abundance, observed richness of families and the sampled specimens were also separated in functional groups. A total of 60 families from 12 orders of Insecta were registered, totaling 19,773 sampled insects. The largest number of families was categorized into predators functional group, with 34 families collected, followed by the collectors with 17, shredders-herbivores ten and scrapers eight.

  16. The association between state attachment security and state Mindfulness.

    Directory of Open Access Journals (Sweden)

    Christopher A Pepping

    Full Text Available Recent research suggests that attachment and mindfulness are related, though the nature of this association is unclear. Here we present two studies examining whether there is a causal relationship between state attachment and state mindfulness. Study 1 investigated the effects of experimentally increasing state mindfulness on state attachment security. State mindfulness was successfully enhanced, but this led to no change in state attachment security. Study 2 investigated the effects of experimentally enhancing state attachment security on state mindfulness. State attachment security was successfully enhanced, but this did not lead to any change in state mindfulness. These findings suggest that there is not a direct, immediate causal relationship between state attachment and state mindfulness as a result of brief experimental manipulations. Future research should examine these associations in longer term interventions.

  17. Regional geologic framework off northeastern United States

    Science.gov (United States)

    Schlee, J.; Behrendt, John C.; Grow, J.A.; Robb, James M.; Mattick, R.; Taylor, P.T.; Lawson, B.J.

    1976-01-01

    Six multichannel seismic-reflection profiles taken across the Atlantic continental margin Previous HitoffTop the northeastern United States show an excess of 14 km of presumed Mesozoic and younger sedimentary rocks in the Baltimore Canyon trough and 8 km in the Georges Bank basin. Beneath the continental rise, the sedimentary prism thickness exceeds 7 km south of New Jersey and Maryland, and it is 4.5 km thick south of Georges Bank. Stratigraphically, the continental slope--outer edge of the continental shelf is a transition zone of high-velocity sedimentary rock, probably carbonate, that covers deeply subsided basement. Acoustically, the sedimentary sequence beneath the shelf is divided into three units which are correlated speculatively with the Cenozoic, the Cretaceous, and the Jurassic-Triassic sections. These units thicken offshore, and some have increased seismic velocities farther offshore. The uppermost unit thickens from a fraction of a kilometer to slightly more than a kilometer in a seaward direction, and velocity values range from 1.7 to 2.2 km/sec. The middle unit thickens from a fraction of a kilometer to as much as 5 km (northern Baltimore Canyon trough), and seismic velocity ranges from 2.2 to 5.4 km/sec. The lowest unit thickens to a maximum of 9 km (northern Baltimore Canyon), and velocities span the 3.9 to 5.9-km/sec interval. The spatial separation of magnetic and gravity anomalies on line 2 (New Jersey) suggests that in the Baltimore Canyon region the magnetic-slope anomaly is due to edge effects and that the previously reported free-air and isostatic gravity anomalies over the outer shelf may be due in part to a lateral increase in sediment density (velocity) near the shelf edge. The East Coast magnetic anomaly and the free-air gravity high both coincide over the outer shelf edge on line 1 (Georges Bank) but are offset by 20 km from the ridge on the reflection profile. Because the magnetic-slope-anomaly wavelength is nearly 50 km across, a

  18. Constructing a State Policy To Promote Regionalism in School Government.

    Science.gov (United States)

    Zukowsky, Jerome; And Others.

    This paper defines regionalism, sets some tentative directions for the concept, and raises difficult questions related to its application in New York State. Regionalism, which offers an alternative to a State-local school governing system, is used to decentralize the planning and management of public services. A regional unit permits district…

  19. Decreased resting-state BOLD regional homogeneity and the intrinsic functional connectivity within dorsal striatum is associated with greater impulsivity in food-related decision-making and BMI change at 6-month follow up.

    Science.gov (United States)

    Gao, Xiao; Liang, Qianlin; Wu, Guorong; She, Ying; Sui, Nan; Chen, Hong

    2018-04-30

    Increasing animal models as well as brain imaging studies among human suggest an association between substance-related impulsivity in decision-making and decreased function of dorsal striatum. However, the resting-state intrinsic functional organization of dorsal striatum underlying food-choice impulsivity remains unknown. To address this issue, we used resting-state functional MRI (rs-fMRI) to measure brain activity among adult females. Subjects underwent the food rating task, during which they rated each food item according to their subjective perception of its taste (from Dislike it very much to Like it very much), its long term effect on health (from very unhealthy to very healthy) and decision strength to eat it (from Strong no to Strong yes). Behaviorally, impulsivity in food-choice was indexed by the decision strength of the palatable high-calorie food rather than of the low-caloric food. Results on rs-fMRI showed that greater impulsivity in food-related decision-making was inversely correlated with spontaneous regional homogeneity in the dorsal striatum (dorsal caudate), as well as the resting-state functional connectivity (rs-FC) between the dorsal caudate seed and the rostral putamen. Furthermore, the caudate-putamen rs-FC inversely predicted BMI change at six-month follow-up. These findings may suggest the insensitivity to reward signals in dorsal caudate in decision-making coupled with an imbalance between goal-directed behaviors (modulated by dorsal caudate) and habitual actions (modulated by putamen) underlying impulsivity and future weight gain. In sum, these findings extend our understanding on the neural basis of food-related impulsivity, and provide evidence for the dorsal striatum as one of the landmarks in over eating and weight change. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. State fragility and its regional implications for peace and stability

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    of the Cold war left a security void, and the fragility, and in some instances collapse, of the state structures resulted in new state formations and new conflicts, both intra- and inter-state in nature. However, conflicts and security challenges in East Africa are due to amongst other things porous borders......, fragile states and bad governance regional in nature, and cannot be solved by the individual states alone. Regional institutions have been in a weak position dealing with these challenges, and attempts have been to strengthen the capacity of these regional institutions. This paper investigates...

  1. High Regional Variation in Urethroplasty in the United States

    Science.gov (United States)

    Figler, Bradley D.; Gore, John L.; Holt, Sarah K.; Voelzke, Bryan B.; Wessells, Hunter

    2015-01-01

    Purpose We identified clinical and regional factors associated with the use of urethroplasty vs repeat endoscopic management for urethral stricture disease. Materials and Methods We analyzed claims for patients 18 to 65 years old in the 2007 to 2011 MarketScan ® Commercial Claims and Encounters Database with a diagnosis of urethral stricture. The primary outcome was treatment with urethroplasty vs repeat endoscopic management, defined as more than 2 dilations or direct vision internal urethrotomies. The likelihood of urethroplasty vs repeat endoscopic management was determined for each major metropolitan area in the United States. Multivariate logistic regression was done to identify factors associated with urethroplasty. Results We identified 41,056 patients with urethral stricture, yielding a diagnosis rate of 296/100,000 men in MarketScan. Repeat endoscopic management and urethroplasty were performed in 2,700 and 1,444 patients, respectively. Compared to patients treated with repeat endoscopic management those with urethroplasty were younger (median age 44 vs 54 years) and more likely to have a Charlson comorbidity score of 0 (84% vs 77%), have traveled out of a metropolitan area for care (34% vs 17%) and have a reconstructive urologist in the treatment metropolitan area (76% and 62%, each p urethroplasty vs repeat endoscopic management. Conclusions Despite the well established benefits of urethroplasty compared to repeat endoscopic management a strong bias for repeat endoscopic management exists in many regions in the United States. PMID:25072180

  2. The association of TB with HIV infection in Oromia Regional ...

    African Journals Online (AJOL)

    ACIPH_Admin

    Regional National State Health Bureau, Shashemene, P.O.Box 138, Ethiopia, Email address, Abera_bekele@ yahoo.com ... service coverage across the region, using all available ..... burden by chest radiography,M.tuberculosis load and.

  3. Methodology to evaluate the energy associated to the industrial solid wastes: application in a metropolitan region of Campinas, Sao Paulo state, Brazil; Metodologia para avaliacao da energia associada ao residuo solido industrial: aplicacao a regiao metropolitada de Campinas

    Energy Technology Data Exchange (ETDEWEB)

    Batista, Tereza Rosana Orrico [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Curso de Pos-graduacao em Planejamento de Sistemas Energeticos; Teixeira, Egle Novaes [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Fac. de Engenharia Civil, Arquitetura e Urbanismo; Silva, Ennio Peres da [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Nucleo Interdisciplinar de Planejamento Energetico. Lab. de Hidrogenio

    2004-07-01

    The aim of this work is to the application of a methodology to evaluate the energy associated to the industrial solid wastes in the metropolitan region of Campinas. The methodological route proposed is: the characterization of the research area and the production/management of the industrial solid wastes; the energetic classification and the qualitative/quantitative research of the energy associated to the industrial solid wastes; and, the valuation of the applicability of the energetic utilization mechanisms proposed to the region. This methodology when applied at the Campinas metropolitan region proved to be valid and it resulted in a synthetically presentation of the social and environmental reality of the industrial sector and the destination of the wastes, as well as it indicated the potentialities related to the energetic utilization of the industrial solid waste in the region. With the obtained results it was shown the importance of the the production and the destination of the industrial solid wastes in the Campinas metropolitan region , and the meaning, in terms of electric potency, of the values of the energy associated to the wastes with a known factor of energetic conversion shown in the researched sample. (author)

  4. Administrative Area Boundaries 2 (State Boundaries), Region 9, 2010, NAVTEQ

    Data.gov (United States)

    U.S. Environmental Protection Agency — NAVTEQ Administrative Area Boundaries 2 (State Boundaries) for Region 9. There are five Administrative Area Boundaries layers (1, 2, 3, 4, 5). These layers contain...

  5. Major Differences between RFCl and SNNP Regional State Family ...

    African Journals Online (AJOL)

    Nigussie Afesha

    SNNP regional state family law contains detail rules that govern it. ..... Since pension benefits are received upon retirement, divorce that predates .... work.” There is discrepancy between the Amharic and English version of Article 216 of.

  6. Final Scientific and Technical Report State and Regional Biomass Partnerships

    Energy Technology Data Exchange (ETDEWEB)

    Handley, Rick; Stubbs, Anne D.

    2008-12-29

    The Northeast Regional Biomass Program successfully employed a three pronged approach to build the regional capacity, networks, and reliable information needed to advance biomass and bioenergy technologies and markets. The approach included support for state-based, multi-agency biomass working groups; direct technical assistance to states and private developers; and extensive networking and partnership-building activities to share objective information and best practices.

  7. Regionalism and State University of New York, 1972-76.

    Science.gov (United States)

    1977

    The State University of New York comprises four formal coordinating areas for the development of regional contacts and interinstitutional and regional cooperation. The four coordinating areas have been operating since 1972 and the differing patterns of cooperation that have emerged are outlined as are the formal activities of each area. Only one…

  8. Power systems simulations of the western United States region

    International Nuclear Information System (INIS)

    Conzelmann, G.; Koritarov, V.; Poch, L.; Thimmapuram, P.; Veselka, T.

    2010-01-01

    This report documents a part of a broad assessment of energy-water-related issues in the western United States. The full analysis involved three Department of Energy national laboratories: Argonne National Laboratory, Los Alamos National Laboratory, and Sandia National Laboratories. Argonne's objective in the overall project was to develop a regional power sector expansion forecast and a detailed unit-level operational (dispatch) analysis. With these two major analysis components, Argonne estimated current and future freshwater withdrawals and consumption related to the operation of U.S. thermal-electric power plants in the Western Electricity Coordinating Council (WECC) region for the period 2005-2025. Water is withdrawn and used primarily for cooling but also for environmental control, such as sulfur scrubbers. The current scope of the analysis included three scenarios: (1) Baseline scenario as a benchmark for assessing the adequacy and cost-effectiveness of water conservation options and strategies, (2) High nuclear scenario, and (3) High renewables scenario. Baseline projections are consistent with forecasts made by the WECC and the Energy Information Administration (EIA) in its Annual Energy Outlook (AEO) (EIA 2006a). Water conservation scenarios are currently limited to two development alternatives that focus heavily on constructing new generating facilities with zero water consumption. These technologies include wind farms and nuclear power plants with dry cooling. Additional water conservation scenarios and estimates of water use associated with fuel or resource extraction and processing will be developed in follow-on analyses.

  9. Substance abuse associated with elder abuse in the United States.

    Science.gov (United States)

    Jogerst, Gerald J; Daly, Jeanette M; Galloway, Lara J; Zheng, Shimin; Xu, Yinghui

    2012-01-01

    Substance abuse by either victim or perpetrator has long been associated with violence and abuse. Sparse research is available regarding elder abuse and its association with substance abuse. The objective of this study was to evaluate the association of state-reported domestic elder abuse with regional levels of substance abuse. Census demographic and elder abuse data were sorted into substate regions to align with the substance use treatment-planning regions for 2269 US counties. From the 2269 US counties there were 229 substate regions in which there were 213,444 investigations of abuse. For the other Ns (reports and substantiations) there were fewer counties and regions. See first sentence of data analyses and first sentence of results. Elder abuse report rates ranged from .03 to .41% (80 regions), investigation rates .001 to .34% (229 regions), and substantiation rates 0 to .22% (184 regions). Elder abuse investigations and substantiations were associated with various forms of substance abuse. Higher investigation rates were significantly associated with a higher rate of any illicit drug use in the past month, a lower median household income, lower proportion of the population graduated high school, and higher population of Hispanics. Higher substantiation rates were significantly associated with higher rate of illicit drug use in the past month and higher population of Hispanics. It may be worthwhile for administrators of violence programs to pay particular attention to substance abuse among their clients and in their community's environment, especially if older persons are involved. Measures of documented elder abuse at the county level are minimal. To be able to associate substance abuse with elder abuse is a significant finding, realizing that the substance abuse can be by the victim or the perpetrator of elder abuse.

  10. Contribution of Large Region Joint Associations to Complex Traits Genetics

    Science.gov (United States)

    Paré, Guillaume; Asma, Senay; Deng, Wei Q.

    2015-01-01

    A polygenic model of inheritance, whereby hundreds or thousands of weakly associated variants contribute to a trait’s heritability, has been proposed to underlie the genetic architecture of complex traits. However, relatively few genetic variants have been positively identified so far and they collectively explain only a small fraction of the predicted heritability. We hypothesized that joint association of multiple weakly associated variants over large chromosomal regions contributes to complex traits variance. Confirmation of such regional associations can help identify new loci and lead to a better understanding of known ones. To test this hypothesis, we first characterized the ability of commonly used genetic association models to identify large region joint associations. Through theoretical derivation and simulation, we showed that multivariate linear models where multiple SNPs are included as independent predictors have the most favorable association profile. Based on these results, we tested for large region association with height in 3,740 European participants from the Health and Retirement Study (HRS) study. Adjusting for SNPs with known association with height, we demonstrated clustering of weak associations (p = 2x10-4) in regions extending up to 433.0 Kb from known height loci. The contribution of regional associations to phenotypic variance was estimated at 0.172 (95% CI 0.063-0.279; p < 0.001), which compared favorably to 0.129 explained by known height variants. Conversely, we showed that suggestively associated regions are enriched for known height loci. To extend our findings to other traits, we also tested BMI, HDLc and CRP for large region associations, with consistent results for CRP. Our results demonstrate the presence of large region joint associations and suggest these can be used to pinpoint weakly associated SNPs. PMID:25856144

  11. 2017 State of Wind Development in the United States by Region

    Energy Technology Data Exchange (ETDEWEB)

    Oteri, Frank A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Baranowski, Ruth E [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Baring-Gould, Edward I [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Tegen, Suzanne I [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-04-13

    This document summarizes the status and drivers for U.S. wind energy development during 2017. Regional Resource Center (RRC) leaders provided a report of wind energy development in their regions, which was combined with findings from National Renewable Energy Laboratory (NREL) researchers to provide an account of the state of the regions, as well as updates on developments in individual states. NREL researchers and state partners added updates for all states that are not directly supported by an RRC. Accounts for each region include updates on renewable portfolio standards, workforce development, manufacturing and economic development, and individual state updates for installed wind capacity, ongoing policy developments, planned projects and their status, transmission progress reports, etc. This report also highlights the efforts of the RRCs to engage stakeholders in their individual regions.

  12. The IPA and the American Psychoanalytic Association: a perspective on the regional association agreement.

    Science.gov (United States)

    Wallerstein, R S

    1998-06-01

    Ever since 1938 the American Psychoanalytic Association has had a special autonomous relationship within the IPA accorded to no other component organisation. This Regional Association status has had two main features: (1) total internal control over training standards and membership criteria, with no accountability to the IPA; and (2) an 'exclusive franchise', so that the IPA was barred from recognising any other component within the United States. This unique Regional Association status reflected the resolution at the time (1938) of the long-standing controversy between the IPA and the American over the issue of 'lay analysis', and remained unaltered for half a century until, with the resolution of the 3 1/2-year long law-suit against the American (and secondarily against the IPA) in 1988, the Regional Association agreement was modified (but not totally abrogated) by the American's giving up the 'exclusive franchise' aspect (thus permitting IPA recognition of psychoanalytic groups in the US organised outside the American), but still retaining its internal full control over training and membership. The meanings and consequences for psychoanalysis of this special status of the American are explored.

  13. State and Regional Control of Geological Carbon Sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Reitze, Arnold [Univ. of Utah, Salt Lake City, UT (United States); Durrant, Marie [Univ. of Utah, Salt Lake City, UT (United States)

    2011-03-01

    The United States has economically recoverable coal reserves of about 261 billion tons, which is in excess of a 250-­year supply based on 2009 consumption rates. However, in the near future the use of coal may be legally restricted because of concerns over the effects of its combustion on atmospheric carbon dioxide concentrations. Carbon capture and geologic sequestration offer one method to reduce carbon emissions from coal and other hydrocarbon energy production. While the federal government is providing increased funding for carbon capture and sequestration, recent congressional legislative efforts to create a framework for regulating carbon emissions have failed. However, regional and state bodies have taken significant actions both to regulate carbon and facilitate its capture and sequestration. This article explores how regional bodies and state government are addressing the technical and legal problems that must be resolved in order to have a viable carbon sequestration program. Several regional bodies have formed regulations and model laws that affect carbon capture and storage, and three bodies comprising twenty-three states—the Regional Greenhouse Gas Initiative, the Midwest Regional Greenhouse Gas Reduction Accord, and the Western Climate initiative—have cap-­and-trade programs in various stages of development. State property, land use and environmental laws affect the development and implementation of carbon capture and sequestration projects, and unless federal standards are imposed, state laws on torts and renewable portfolio requirements will directly affect the liability and viability of these projects. This paper examines current state laws and legislative efforts addressing carbon capture and sequestration.

  14. United States - Japanese nuclear relations: implications for the pacific region

    International Nuclear Information System (INIS)

    Suttmeier, R.P.

    1980-01-01

    The initiation of a new approach to non-proliferation policy by the United States in 1977 was the most upsetting development in the history of US-Japanese nuclear relations. The policy has seemingly altered Japanese views of its own nuclear future very little, yet it has altered the tone of the nuclear relationship with the United States. Recent Japanese nuclear power developments, both technical and administrative, are outlined and the prospects for the future of the United States-Japanese nuclear relationship and for Pacific regional cooperation assessed. Issues of importance in the relationship include reprocessing - enrichment, plutonium management, spent fuel and waste management and uranium supplies

  15. Gambiense Sleeping Sickness In The Abraka Region Of Delta State ...

    African Journals Online (AJOL)

    Gambiense Sleeping Sickness In The Abraka Region Of Delta State, Nigeria: Passive Case Detection (Pcd) At The Baptist Medical Centre (BMC) Eku 1999 – 2004. ... The highest prevalence of infection was among patients aged between 26-35 years with 35.6% infection rate, 23.3 percent was recorded among those aged ...

  16. Energy and minerals industries in national, regional, and state economies

    Science.gov (United States)

    D. J. Shields; S. A. Winter; G. S. Alward; K. L. Hartung

    1996-01-01

    This report presents information on the contribution of the extractive industries to the domestic economy at different geopolitical scales. Areas where resource production is important to gross state or regional product, employment, or income are highlighted. Output, employment, value added, and personal and total income multipliers are reported for the energy and...

  17. ( Mangifera indica L.) in Harari Regional State, Eastern Ethiopia

    African Journals Online (AJOL)

    Mango production covers 35% of the total acreage allotted for fruit production in Harari Regional State, eastern Ethiopia. However, there is a declining trend in yield and quality of fruits from the trees. Therefore, this study was conducted to assess the status, practices and challenges of mango production in the study area.

  18. Improving of State Regional Policy Mechanism at Risks` Conditions

    Directory of Open Access Journals (Sweden)

    Roman Tarasovich Lukysha

    2015-10-01

    Full Text Available Modernization and innovatization were defined as the ways of improvement of the state policy of regional development from the safety perspective. They stipulate the following: 1 avoidance of the possible risks of the development of regions providing for the refusal of the unreliable programs and projects, unreasonable taking on credit and other kinds of loans; 2 risk sharing and convergence, as well as the reduction of their influence on the results of administrative activity; 3 determination and prevention of negative effect of risks. It was offered to carry out the improvement of the state policy of the development of regions with the help of the forming of stable organizational and informational network and system. It was specified that the difference between the latter is in the fact that the organizational and informational system concerns the financial side of administrative activity in regions. This means that it ensures the observance of the principle of transparency. While the organizational and informational network reflects its procedural side with the concept of openness being the basis of such activity. The improvement of the procedure of the organization of state administration of risks of the regional development was proved. It was established that organization of the state administration of the risks of regions development has a form of a chain: “provision of power and powers to the public authority → establishment of the new structural unit or addition of the existing administrative formations, approval of the functional regulations, official duties, etc. → competitive selection of the officials, their training, retraining, consulting → performance by them of the direct tasks on the detection and the prevention of the negative influence of dangers and threats.”

  19. Small State Strategies in emerging Regional Governance Structures

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Lynggaard, Kennet

    2017-01-01

    This article departs from the puzzling observation that of the five littoral arctic states the Danish realm has been the most consistent backer in China’s quest to gain observer status in the Arctic Council. Small states are generally assumed to adapt to changes in the international system...... such as spatial reconfigurations and alterations in the distribution of capabilities. Yet Denmark’s enabling role in relation to China seems to contravene that assumption. Why would a small state invite one of the world’s leading powers to enter its regional domain while its principle allies and regional partners...... explanation suggesting that unease with growing Canadian securitisation of Arctic issues has prompted courting China as a balancing act. 3) a foreign policy identity explanation focussing on the normative desire to enmeshment China into a liberal Arctic order....

  20. 77 FR 11022 - Approval and Promulgation of Implementation Plans; State of Alaska; Regional Haze State...

    Science.gov (United States)

    2012-02-24

    ... protocol was developed. See Figure III.K.5-2 of the SIP submittal. Included Sources--Emission sources... Implementation Plan (SIP) revision, submitted by the State of Alaska on April 4, 2011, as meeting the.... Requirements for Regional Haze SIPs A. The CAA and the Regional Haze Rule B. Baseline, Natural Conditions, and...

  1. Mexico: a regional power or a failed State?

    Directory of Open Access Journals (Sweden)

    Karol Derwich

    2015-10-01

    Caribbean region for many years. This opinion has strong foundations. Territory, geographical location, economy, and political influence are the key factors that predestine this country to the role of a regional power. The democratic transition that has taken place in Mexico in last decades and economic cooperation with the United States also allow it to play a role of regional leader. However, Mexico has significant problems that make it difficult for the country to play the role of a real leader. The most important one is the development of narcobusiness. This phenomenon brings not only the growing activity of drug cartels but also the eruption of narcoviolence in Mexico. This gives rise to grave problems for the Mexican authorities. The development of narcobusiness is partially the result of weakness of some of its institutions. For example, police forces do not carry out their tasks and are closely related to the drug cartels. As a result, the Mexican state is incapable of assuring security to its citizens – one of the most important functions of every state. Is it able to control its territory? It definitely does not have a monopoly for the use of violence on its territory. Huge corruption enables different non-state actors to influence decision making processes. All these problems make substantiated theses that the Mexican state is dysfunctional in some areas. Some analysts go much further in their opinions and describe Mexico as a failed state. The aim of the paper is to analyze the present position of Mexico in Latin America and the Caribbean region. Are the contemporary problems so big that they can lead to the collapse of the Mexican state or does Mexico have a real potential to play the role of a local leader and regional power? The author would like to analyze the impact of the present day internal problems in Mexico’s geopolitical position.

  2. Coherent states associated to the Jacobi group

    International Nuclear Information System (INIS)

    Berceanu, S.

    2007-01-01

    .The coherent states (CS) offer a useful connection between classical and quantum mechanics. In several previous works we have constructed CS attached to the Jacobi group. It is well known that the Jacobi group appears in Quantum Mechanics, Geometric Quantization, Optics. The mathematicians have given the name 'Jacobi group' to the semidirect product of the Heisenberg-Weyl group and the symplectic group. The same group is known to physicists under other names, as the Schroedinger group. Also the name 'Weyl-symplectic' group is used for the same semi-direct product of the Heisenberg-Weyl group and the symplectic group. In this paper we review and discuss some properties of the coherent states associated to the Jacobi group. (author)

  3. Crop Yield Simulations Using Multiple Regional Climate Models in the Southwestern United States

    Science.gov (United States)

    Stack, D.; Kafatos, M.; Kim, S.; Kim, J.; Walko, R. L.

    2013-12-01

    Agricultural productivity (described by crop yield) is strongly dependent on climate conditions determined by meteorological parameters (e.g., temperature, rainfall, and solar radiation). California is the largest producer of agricultural products in the United States, but crops in associated arid and semi-arid regions live near their physiological limits (e.g., in hot summer conditions with little precipitation). Thus, accurate climate data are essential in assessing the impact of climate variability on agricultural productivity in the Southwestern United States and other arid regions. To address this issue, we produced simulated climate datasets and used them as input for the crop production model. For climate data, we employed two different regional climate models (WRF and OLAM) using a fine-resolution (8km) grid. Performances of the two different models are evaluated in a fine-resolution regional climate hindcast experiment for 10 years from 2001 to 2010 by comparing them to the North American Regional Reanalysis (NARR) dataset. Based on this comparison, multi-model ensembles with variable weighting are used to alleviate model bias and improve the accuracy of crop model productivity over large geographic regions (county and state). Finally, by using a specific crop-yield simulation model (APSIM) in conjunction with meteorological forcings from the multi-regional climate model ensemble, we demonstrate the degree to which maize yields are sensitive to the regional climate in the Southwestern United States.

  4. Influence of globalization on the state management by regional development

    Directory of Open Access Journals (Sweden)

    V. H. Kovalchuk

    2015-03-01

    Full Text Available It is detected that substantial influence on the state management by regional development have done the processes of globalization, particularly the transference from programs to strategies of regions development was held. Wherein there are a lot of social and economic benefits connected with usage of regional development strategies in the globalized world compared with traditional programs of development, the main of which are the following: strategies give more authority to local communities and contribute to dialogue establishing; strategies help to make the work of regional authorities more clear and responsible, and also they contribute the development of citizens community on the local level; strategies contribute the stable growing and creating of employment in local enterprises, which are able to adapt to conditions of socially economic situation in the World that changes permanently because of its orientation to the socially economic activity of particular territory depended on competitive benefits and features of its territory; strategies thanks to attraction to their realization of local entities interested in region development, and also because of economic activity improvement on particular territory contribute the quality increase of working places. Keywords: governance, regional development strategy, the processes of globalization.

  5. 77 FR 38191 - Approval and Promulgation of Implementation Plans; State of Mississippi; Regional Haze State...

    Science.gov (United States)

    2012-06-27

    ... SIP submittal followed the VISTAS modeling protocol and considered the contribution of total PM 10 and... revisions to the Mississippi State Implementation Plan (SIP) submitted by the State of Mississippi through.... Mississippi's SIP revisions address regional haze for the first implementation period. Specifically, these SIP...

  6. Development of Euler's ideas at the Moscow State Regional University

    Science.gov (United States)

    Vysikaylo, P. I.; Belyaev, V. V.

    2018-03-01

    In honor of the 250th anniversary of Euler's discovery of three libration points in Russia in 1767 in the area of two rotating gravitational attractors in 2017 an International Interdisciplinary Conference “Euler Readings MRSU 2017” was held in Moscow Region State University (MRSU). The Conference demonstrated that the Euler's ideas continue to remain relevant at the present time. This paper summarizes the main achievements on the basis of Leonard Euler's ideas presented at the Conference.

  7. Searching for Compact Radio Sources Associated with UCH ii Regions

    Energy Technology Data Exchange (ETDEWEB)

    Masqué, Josep M.; Trinidad, Miguel A.; Rodríguez-Rico, Carlos A. [Departamento de Astronomía, Universidad de Guanajuato, Apdo. Postal 144, 36000 Guanajuato, México (Mexico); Rodríguez, Luis F.; Kurtz, Stan; Loinard, Laurent [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Morelia 58089, México (Mexico); Dzib, Sergio A. [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany)

    2017-02-10

    Ultra-compact (UC)H ii regions represent a very early stage of massive star formation. The structure and evolution of these regions are not yet fully understood. Interferometric observations showed in recent years that compact sources of uncertain nature are associated with some UCH ii regions. To examine this, we carried out VLA 1.3 cm observations in the A configuration of selected UCH ii regions in order to report additional cases of compact sources embedded in UCH ii regions. With these observations, we find 13 compact sources that are associated with 9 UCH ii regions. Although we cannot establish an unambiguous nature for the newly detected sources, we assess some of their observational properties. According to the results, we can distinguish between two types of compact sources. One type corresponds to sources that are probably deeply embedded in the dense ionized gas of the UCH ii region. These sources are photoevaporated by the exciting star of the region and will last for 10{sup 4}–10{sup 5} years. They may play a crucial role in the evolution of the UCH ii region as the photoevaporated material could replenish the expanding plasma and might provide a solution to the so-called lifetime problem of these regions. The second type of compact sources is not associated with the densest ionized gas of the region. A few of these sources appear resolved and may be photoevaporating objects such as those of the first type, but with significantly lower mass depletion rates. The remaining sources of this second type appear unresolved, and their properties are varied. We speculate on the similarity between the sources of the second type and those of the Orion population of radio sources.

  8. Regional cerebral blood flow in the persistent vegetative state

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Masaharu; Kuroda, Ryotaro; Ioku, Masahiko [Kinki Univ., Osakasayama, Osaka (Japan). Faculty of Medicine; and others

    1989-05-01

    Regional cerebral blood flow (CBF) in eight patients in a persistent vegetative state was measured and compared with that in five healthy volunteers. The patients were classified into three groups: Group 1 (locked-in syndrome) consisted of a single patient, Group 2 (typical vegetative state) of five patients, and Group 3 (prolonged coma) of two patients. CBF was measured early after onset by single photon emission computed tomography with {sup 123}I-N-isopropyl-p-iodo-amphetamine and/or {sup 99m}Tc-hexamethyl-propyleneamine oxime. The regions of interest (ROIs) were the bilateral frontal, temporal, parietal, occipital, and cerebellar areas and basal ganglia. The values obtained in these areas were averaged, and the ratio for each ROI ((the value in the ROI/the mean value) x 100) was calculated. 'Hyper-frontal distribution' of CBF was found to be rare in both the normal condition and the vegetative state. Higher CBF values were noted in the left than in the right frontal area in four of the five volunteers but in only four of the eight patients. CBF distribution in the frontal lobe was characteristic for each group: Group 1 showed high CBF bilaterally, although the elevation was statistically significant only on the right side, and Group 3 exhibited significantly low values. In Group 2, CBF was variable but, for the most part, within normal limits. Awareness was closely correlated with frontal lobe function and alteration of CBF in the frontal region. (author).

  9. Trends in Tuberculosis Reported from the Appalachian Region: United States, 1993-2005

    Science.gov (United States)

    Wallace, Ryan M.; Armstrong, Lori R.; Pratt, Robert H.; Kammerer, J. Steve; Iademarco, Michael F.

    2008-01-01

    Context: Appalachia has been characterized by its poverty, a factor associated with tuberculosis, yet little is known about the disease in this region. Purpose: To determine whether Appalachian tuberculosis risk factors, trends, and rates differ from the rest of the United States. Methods: Analysis of tuberculosis cases reported to the Centers for…

  10. Associations for Citizen Science: Regional Knowledge, Global Collaboration

    Directory of Open Access Journals (Sweden)

    Martin Storksdieck

    2016-11-01

    Full Text Available Since 2012, three organizations advancing the work of citizen science practitioners have arisen in different regions: The primarily US-based but globally open Citizen Science Association (CSA, the European Citizen Science Association (ECSA, and the Australian Citizen Science Association (ACSA. These associations are moving rapidly to establish themselves and to develop inter-association collaborations. We consider the factors driving this emergence and the significance of this trend for citizen science as a field of practice, as an area of scholarship, and for the culture of scientific research itself.

  11. Approximate Dynamic Programming: Combining Regional and Local State Following Approximations.

    Science.gov (United States)

    Deptula, Patryk; Rosenfeld, Joel A; Kamalapurkar, Rushikesh; Dixon, Warren E

    2018-06-01

    An infinite-horizon optimal regulation problem for a control-affine deterministic system is solved online using a local state following (StaF) kernel and a regional model-based reinforcement learning (R-MBRL) method to approximate the value function. Unlike traditional methods such as R-MBRL that aim to approximate the value function over a large compact set, the StaF kernel approach aims to approximate the value function in a local neighborhood of the state that travels within a compact set. In this paper, the value function is approximated using a state-dependent convex combination of the StaF-based and the R-MBRL-based approximations. As the state enters a neighborhood containing the origin, the value function transitions from being approximated by the StaF approach to the R-MBRL approach. Semiglobal uniformly ultimately bounded (SGUUB) convergence of the system states to the origin is established using a Lyapunov-based analysis. Simulation results are provided for two, three, six, and ten-state dynamical systems to demonstrate the scalability and performance of the developed method.

  12. United States Army Regionally Aligned Forces: Opportunities for the Future

    Science.gov (United States)

    2014-05-22

    dispersed force, curriculum adaptability, and cost efficiency are paramount. In response to increased requirements a commercial-off-the-shelf online virtual ...actors’ perceptions and perceived realities . So the question for the regionally aligned force is how to educate and train its leadership to understand...the costs associated in doing so. Granted, there is a point of self- diminishing returns when too much specificity lurches towards myopia , but soldier

  13. Regional risk associated with the transport of hazardous materials

    OpenAIRE

    Nardini, L.; Aparicio, L.; Bandoni, A.; Tonelli, S. M.

    2003-01-01

    An increasing concern over the level of risk associated with hazardous materials transportation has led international efforts to focus on risk assessment at regional level. Following this trend, the aim of this work is to review the latest procedures for analysing the regional risks resulting from hazardous materials transportation by means of road and rail. In particular, two methodologies are reviewed and discussed, a method recently developed at Swiss Federal Institute of Technology [1] an...

  14. Regional socioeconomic disparities in outcomes for workers with low back pain in the United States.

    Science.gov (United States)

    Shraim, Mujahed; Cifuentes, Manuel; Willetts, Joanna L; Marucci-Wellman, Helen R; Pransky, Glenn

    2017-05-01

    Although regional socioeconomic (SE) factors have been associated with worse health outcomes, prior studies have not addressed important confounders or work disability. A national sample of 59 360 workers' compensation (WC) cases to evaluate impact of regional SE factors on medical costs and length of disability (LOD) in occupational low back pain (LBP). Lower neighborhood median household incomes (MHI) and higher state unemployment rates were associated with longer LOD. Medical costs were lower in states with more workers receiving Social Security Disability, and in areas with lower MHI, but this varied in magnitude and direction among neighborhoods. Medical costs were higher in more urban, more racially diverse, and lower education neighborhoods. Regional SE disparities in medical costs and LOD occur even when health insurance, health care availability, and indemnity benefits are similar. Results suggest opportunities to improve care and disability outcomes through targeted health care and disability interventions. © 2017 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.

  15. Intergenic disease-associated regions are abundant in novel transcripts.

    Science.gov (United States)

    Bartonicek, N; Clark, M B; Quek, X C; Torpy, J R; Pritchard, A L; Maag, J L V; Gloss, B S; Crawford, J; Taft, R J; Hayward, N K; Montgomery, G W; Mattick, J S; Mercer, T R; Dinger, M E

    2017-12-28

    Genotyping of large populations through genome-wide association studies (GWAS) has successfully identified many genomic variants associated with traits or disease risk. Unexpectedly, a large proportion of GWAS single nucleotide polymorphisms (SNPs) and associated haplotype blocks are in intronic and intergenic regions, hindering their functional evaluation. While some of these risk-susceptibility regions encompass cis-regulatory sites, their transcriptional potential has never been systematically explored. To detect rare tissue-specific expression, we employed the transcript-enrichment method CaptureSeq on 21 human tissues to identify 1775 multi-exonic transcripts from 561 intronic and intergenic haploblocks associated with 392 traits and diseases, covering 73.9 Mb (2.2%) of the human genome. We show that a large proportion (85%) of disease-associated haploblocks express novel multi-exonic non-coding transcripts that are tissue-specific and enriched for GWAS SNPs as well as epigenetic markers of active transcription and enhancer activity. Similarly, we captured transcriptomes from 13 melanomas, targeting nine melanoma-associated haploblocks, and characterized 31 novel melanoma-specific transcripts that include fusion proteins, novel exons and non-coding RNAs, one-third of which showed allelically imbalanced expression. This resource of previously unreported transcripts in disease-associated regions ( http://gwas-captureseq.dingerlab.org ) should provide an important starting point for the translational community in search of novel biomarkers, disease mechanisms, and drug targets.

  16. Regional State Committees Can Help Provide a Regional Perspective to Planning and Siting Decisions, Reducing the Need for Federal Preemption

    Energy Technology Data Exchange (ETDEWEB)

    Basheda, Gregory

    2006-03-01

    The Energy Policy Act of 2005 gave FERC the authority to preempt state and local transmission siting authorities under certain conditions, creating the potential for federal/state disputes. Such disputes are less likely to occur where there are open, regional planning processes. Multi-state advisory bodies known as regional state committees, working with RTOs, can provide a forum to evaluate transmission needs from a regional perspective, reducing the need for FERC involvement. (author)

  17. Prospects for regional safeguards systems - State-level Approach

    International Nuclear Information System (INIS)

    Peixoto, O.J.M.

    2013-01-01

    The increased co-operation with Regional Safeguard's System (RSAC) is a relevant tool for strengthening effectiveness and improving the efficiency of the international safeguard. The new safeguards system that emerges from the application of the Additional Protocol (INFCIRC/540) and the full use of State-level Concept is a challenge and an opportunity for effectively incorporate RSAC into the international safeguards scheme. The challenge is to determine how the co-operation and coordination will be implemented on this new safeguards scheme. This paper presents some discussions and prospects on the issues to be faced by RSAC and IAEA during the implementation of State-level Approach (SLA) using all information available. It is also discussed how different levels of co-operation could be achieved when SLA is applied by IAEA safeguards. The paper is followed by the slides of the presentation. (authors)

  18. Seismic and Tectonic Regionalization of the State of Michoacan.

    Science.gov (United States)

    Vazquez Rosas, R.; Aguirre, J.; Garduño-Monroy, V. H.; Ramirez-Guzman, L.

    2017-12-01

    In Mexico it is a country with seismically active regions, mainly the zones that are next to the pacific where the zone of subduction is located, in this work we focus on the state of Michoacán, since this has not been completely studied in the last 30 years after the earthquake in Michoacán in 1985. The first most important step is to know the region which are the most seismic zones within the state and one way is to carry out the regionalization of Michoacán identifying the sources of earthquakes as well as where occur more frequently.If we could know each of the factors that influence seismicity and describe every point of the terrain, every rupture, every rock, etc., then we could describe in an analytical way the seismic process and predict the occurrence of earthquakes such as eclipses. Unfortunately the number of parameters is so enormous that we cannot arrive at an exact description; however, we can take advantage of statistical properties to evaluate probabilities, even in the case of small systems such as a particular seismic zone.In this paper, epicenter data were collected from 1970 to 2014, and with them a statistical study was carried out and the epicenter data plotted using data reported by the National Seismological Service and the IRIS catalog as well as some data from the Institute of engineering UNAM. Where earthquakes of equal and greater than M = 4 were used. Graphing these in function with the depth and with that it was graficaron and was made an overlapping the faults of the state and with that it was divided in 4 seismic zones in function of the faults and the localized seismicity.Zone A. is located within the Michoacán Block set of faults, as well as part of the subduction zone on the coast of the state. Seismicity in this area is high. Zone B-1. This is located between the limits of Jalisco and Michoacán in the set of faults called Tepalcatepec depression and limits with the Jorullo-Tacámbaro fracture. At this site seismicity is

  19. Seismic hazard assessment of the Hanford region, Eastern Washington State

    International Nuclear Information System (INIS)

    Youngs, R.R.; Coppersmith, K.J.; Power, M.S.; Swan, F.H. III

    1985-01-01

    A probabilistic seismic hazard assessment was made for a site within the Hanford region of eastern Washington state, which is characterized as an intraplate region having a relatively low rate of seismic activity. Probabilistic procedures, such as logic trees, were utilized to account for the uncertainties in identifying and characterizing the potential seismic sources in the region. Logic trees provide a convenient, flexible means of assessing the values and relative likelihoods of input parameters to the hazard model that may be dependent upon each other. Uncertainties accounted for in this way include the tectonic model, segmentation, capability, fault geometry, maximum earthquake magnitude, and earthquake recurrence rate. The computed hazard results are expressed as a distribution from which confidence levels are assessed. Analysis of the results show the contributions to the total hazard from various seismic sources and due to various earthquake magnitudes. In addition, the contributions of uncertainties in the various source parameters to the uncertainty in the computed hazard are assessed. For this study, the major contribution to uncertainty in the computed hazard are due to uncertainties in the applicable tectonic model and the earthquake recurrence rate. This analysis serves to illustrate some of the probabilistic tools that are available for conducting seismic hazard assessments and for analyzing the results of these studies. 5 references, 7 figures

  20. Breastfeeding practices and policies in WHO European Region Member States.

    Science.gov (United States)

    Bagci Bosi, Ayse Tulay; Eriksen, Kamilla Gehrt; Sobko, Tanja; Wijnhoven, Trudy M A; Breda, João

    2016-03-01

    To provide an update on current practices and policy development status concerning breastfeeding in the WHO European Region. National surveys and studies conducted by national health institutions were prioritized. Sub-national data were included where no national data or studies existed. Information on national breastfeeding policies was collected mainly from the WHO Seventh Meeting of Baby-Friendly Hospital Initiative Coordinators and European Union projects. Owing to the different data sources and methods, any comparisons between countries must be made with caution. WHO European Member States. Data from fifty-three WHO European Member States were investigated; however, a large proportion had not reported any data. Rates of early initiation of breastfeeding, exclusive breastfeeding and continued breastfeeding to 1 year all varied considerably within the WHO European Region. Exclusive breastfeeding rates declined considerably after 4 months, and were low in infants under 6 months and at 6 months of age. The majority of the countries with existing data reported having a national infant and young child feeding policy and the establishment of a national committee on breastfeeding or infant and young child feeding. The majority of the countries with existing data reported having baby-friendly hospitals, although the proportion of baby-friendly hospitals to the total number of national hospitals with maternity units was low in most countries. Breastfeeding practices within the WHO European Region, especially exclusive breastfeeding rates, are far from complying with the WHO recommendations. There are marked differences between countries in breastfeeding practices, infant and young child feeding policy adoption and proportion of baby-friendly hospitals.

  1. 77 FR 38185 - Approval and Promulgation of Implementation Plans; State of North Carolina; Regional Haze State...

    Science.gov (United States)

    2012-06-27

    ... the differences in averaging time under BART, the Transport Rule, and in measuring visibility impacts..., Group Leader, Geographic Strategies Group, OAQPS, to Kay Prince, Branch Chief, EPA Region 4, July 19... in response to the Federal Land Managers' (FLMs') request that the State describe a plan to consult...

  2. Regionalization of ground motion attenuation in the conterminous United States

    International Nuclear Information System (INIS)

    Chung, D.H.; Bernreuter, D.L.

    1979-01-01

    Attenuation results from geometric spreading and from absorption. The former is almost independent of crustal geology or physiographic region. The latter depends strongly on crustal geology and the state of the earth's upper mantle. Except for very high-frequency waves, absorption does not affect ground motion at distances less than 25 to 50 km. Thus, in the near-field zone, the attenuation in the eastern United States will be similar to that in the western United States. Most of the differences in ground motion can be accounted for by differences in attenuation caused by differences in absorption. The other important factor is that for some Western earthquakes the fault breaks the earth's surface, resulting in larger ground motion. No Eastern earthquakes are known to have broken the earth's surface by faulting. The stress drop of Eastern earthquakes may be higher than for Western earthquakes of the same seismic moment, which would affect the high-frequency spectral content. This factor is believed to be of much less significance than differences in absorption in explaining the differences in ground motion between the East and the West. 6 figures

  3. Effect of Geography on the Analysis of Coccidioidomycosis-Associated Deaths, United States.

    Science.gov (United States)

    Noble, Jason A; Nelson, Robert G; Fufaa, Gudeta D; Kang, Paul; Shafir, Shira Chani; Galgiani, John N

    2016-10-01

    Because coccidioidomycosis death rates vary by region, we reanalyzed coccidioidomycosis-associated mortality in the United States by race/ethnicity, then limited analysis to Arizona and California. Coccidioidomycosis-associated deaths were shown to increase among African-Americans but decrease among Native Americans and Hispanics. Separately, in a Native American cohort, diabetes co-varied with coccidioidomycosis-associated death.

  4. 2016 State of Wind Development in the United States by Region

    Energy Technology Data Exchange (ETDEWEB)

    Baranowski, Ruth [National Renewable Energy Lab. (NREL), Golden, CO (United States); Oteri, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tegen, Suzanne [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-04-19

    Significant expansion of wind energy development will be required to achieve the scenarios outlined in the U.S. Department of Energy's (DOE)'s Wind Vision: 20% wind energy by 2030 and 35% wind energy by 2050. Wind energy currently provides nearly 5% of the nation's electricity but has the potential to provide much more. The wind industry and the DOE's Wind Energy Technologies Office are addressing technical wind energy challenges, such as reducing turbine costs and increasing energy production and reliability. The Office recognizes that public acceptance of wind energy can be challenging, depending on the proximity of proposed wind farms to local populations. Informed decision makers and communities equipped with unbiased information about the benefits and impacts of wind energy development are better prepared to navigate the sometimes contentious development process. In 2014, DOE established six Regional Resource Centers (RRCs) across the United States to communicate unbiased, credible information about wind energy to stakeholders through regional networks. The RRCs provide ready access to this information to familiarize the public with wind energy; raise awareness about potential benefits and issues; and disseminate data on siting considerations such as turbine sound and wildlife habitat protection. This document summarizes the status and drivers for U.S. wind energy development during 2016. RRC leaders provided a report of wind energy development in their regions, which was combined with findings from National Renewable Energy Laboratory (NREL) researchers to provide an account of the state of the regions, as well as updates on developments in individual states. NREL researchers and state partners added updates for all states that are not directly supported by an RRC. Accounts for each region include updates on renewable portfolio standards, the Clean Power Plan, workforce development, manufacturing and economic development, and individual

  5. Capacity region of the 3 receiver state dependent multilevel BC with noncausal state information

    Directory of Open Access Journals (Sweden)

    Viswanathan Ramachandran

    2017-09-01

    Full Text Available We consider a three receiver state dependent multilevel broadcast channel (BC, where the state information is known non-causally at the encoder as well as all the decoders. This is an extension of Nair and El Gamal’s three receiver multilevel BC (Nair and El Gamal, 2009, wherein two of the receivers decode only a common message while a third receiver decodes a private message as well. The objective is to characterize the rate tuples that are simultaneously achievable while ensuring negligible probability of error at each of the receivers. We characterize the capacity region of this setup in the paper.

  6. High-spin states and coexisting states in the Pt-Au transition region

    International Nuclear Information System (INIS)

    Riedinger, L.L.; Carpenter, M.P.; Courtney, L.H.; Janzen, V.P.; Schmitz, W.

    1986-01-01

    High-spin states in the N = 104 to 108 region have been studied by in-beam spectroscopy techniques in a number of Ir, Pt, and Au nuclei. These measurements have been performed at tandem Van de Graaff facilities at the Oak Ridge National Laboratory and at McMaster University. Through comparison of band crossings in a variety of odd-A and even-A nuclei, we are able to assign the first neutron and first proton alignment processes, which are nearly degenerate for 184 Pt. These measurements yield the trend of these crossing frequencies with N and Z in this region. Knowledge of this trend is important, since these crossing frequencies can give an estimate of how the shape parameters vary across this transitional region. 22 refs., 7 figs., 1 tab

  7. Stability of whole brain and regional network topology within and between resting and cognitive states.

    Science.gov (United States)

    Rzucidlo, Justyna K; Roseman, Paige L; Laurienti, Paul J; Dagenbach, Dale

    2013-01-01

    Graph-theory based analyses of resting state functional Magnetic Resonance Imaging (fMRI) data have been used to map the network organization of the brain. While numerous analyses of resting state brain organization exist, many questions remain unexplored. The present study examines the stability of findings based on this approach over repeated resting state and working memory state sessions within the same individuals. This allows assessment of stability of network topology within the same state for both rest and working memory, and between rest and working memory as well. fMRI scans were performed on five participants while at rest and while performing the 2-back working memory task five times each, with task state alternating while they were in the scanner. Voxel-based whole brain network analyses were performed on the resulting data along with analyses of functional connectivity in regions associated with resting state and working memory. Network topology was fairly stable across repeated sessions of the same task, but varied significantly between rest and working memory. In the whole brain analysis, local efficiency, Eloc, differed significantly between rest and working memory. Analyses of network statistics for the precuneus and dorsolateral prefrontal cortex revealed significant differences in degree as a function of task state for both regions and in local efficiency for the precuneus. Conversely, no significant differences were observed across repeated sessions of the same state. These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

  8. Stability of whole brain and regional network topology within and between resting and cognitive states.

    Directory of Open Access Journals (Sweden)

    Justyna K Rzucidlo

    Full Text Available BACKGROUND: Graph-theory based analyses of resting state functional Magnetic Resonance Imaging (fMRI data have been used to map the network organization of the brain. While numerous analyses of resting state brain organization exist, many questions remain unexplored. The present study examines the stability of findings based on this approach over repeated resting state and working memory state sessions within the same individuals. This allows assessment of stability of network topology within the same state for both rest and working memory, and between rest and working memory as well. METHODOLOGY/PRINCIPAL FINDINGS: fMRI scans were performed on five participants while at rest and while performing the 2-back working memory task five times each, with task state alternating while they were in the scanner. Voxel-based whole brain network analyses were performed on the resulting data along with analyses of functional connectivity in regions associated with resting state and working memory. Network topology was fairly stable across repeated sessions of the same task, but varied significantly between rest and working memory. In the whole brain analysis, local efficiency, Eloc, differed significantly between rest and working memory. Analyses of network statistics for the precuneus and dorsolateral prefrontal cortex revealed significant differences in degree as a function of task state for both regions and in local efficiency for the precuneus. Conversely, no significant differences were observed across repeated sessions of the same state. CONCLUSIONS/SIGNIFICANCE: These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

  9. Productivity Effects of United States Multinational Enterprises : The Roles of Market Orientation and Regional Integration

    NARCIS (Netherlands)

    Smeets, Roger; Wei, Yingqi

    2010-01-01

    Smeets R. and Wei Y. Productivity effects of United States multinational enterprises: the roles of market orientation and regional integration, Regional Studies. This paper considers the role of market orientation and regional integration in foreign direct investment (FDI) productivity effects.

  10. Prediction of lake depth across a 17-state region in the United States

    Science.gov (United States)

    Oliver, Samantha K.; Soranno, Patricia A.; Fergus, C. Emi; Wagner, Tyler; Winslow, Luke A.; Scott, Caren E.; Webster, Katherine E.; Downing, John A.; Stanley, Emily H.

    2016-01-01

    Lake depth is an important characteristic for understanding many lake processes, yet it is unknown for the vast majority of lakes globally. Our objective was to develop a model that predicts lake depth using map-derived metrics of lake and terrestrial geomorphic features. Building on previous models that use local topography to predict lake depth, we hypothesized that regional differences in topography, lake shape, or sedimentation processes could lead to region-specific relationships between lake depth and the mapped features. We therefore used a mixed modeling approach that included region-specific model parameters. We built models using lake and map data from LAGOS, which includes 8164 lakes with maximum depth (Zmax) observations. The model was used to predict depth for all lakes ≥4 ha (n = 42 443) in the study extent. Lake surface area and maximum slope in a 100 m buffer were the best predictors of Zmax. Interactions between surface area and topography occurred at both the local and regional scale; surface area had a larger effect in steep terrain, so large lakes embedded in steep terrain were much deeper than those in flat terrain. Despite a large sample size and inclusion of regional variability, model performance (R2 = 0.29, RMSE = 7.1 m) was similar to other published models. The relative error varied by region, however, highlighting the importance of taking a regional approach to lake depth modeling. Additionally, we provide the largest known collection of observed and predicted lake depth values in the United States.

  11. Sensitivity analysis of the impacts of operational and geologic conditions on Area of Review (AOR, Post Injection Site Care (PISC and Risk associated with CO2 Sequestration in South-region of United States

    Directory of Open Access Journals (Sweden)

    Danilo Andrés Arcentales Bastidas

    2017-12-01

    Full Text Available For anthropogenic carbon dioxide (CO2 capture is important to consider: gas storage’s formation capacity, saturation and pressure plume size after injection; including the risks associated with CO2 leakage and faults reactivation. A formation with a reasonable pore volume would be a good candidate for CO2 storage, however, not all high porosity formations have the ability to store large amounts of gas over a long period of time. That's the biggest concern when it refers to CO2 capture. Saturation and pressure plume size during CO2 injection as well as site monitoring after injection were simulated in this research, using CRD field reservoir models. The application of Pareto diagrams and surface responses allowed us to determine the most important parameters that affected the saturation and pressure plume, quantifying the correlation between different parameters of adjusted and dimensioned historical models.

  12. The United States National Climate Assessment - Alaska Technical Regional Report

    Science.gov (United States)

    Markon, Carl J.; Trainor, Sarah F.; Chapin, F. Stuart; Markon, Carl J.; Trainor, Sarah F.; Chapin, F. Stuart

    2012-01-01

    The Alaskan landscape is changing, both in terms of effects of human activities as a consequence of increased population, social and economic development and their effects on the local and broad landscape; and those effects that accompany naturally occurring hazards such as volcanic eruptions, earthquakes, and tsunamis. Some of the most prevalent changes, however, are those resulting from a changing climate, with both near term and potential upcoming effects expected to continue into the future. Alaska's average annual statewide temperatures have increased by nearly 4°F from 1949 to 2005, with significant spatial variability due to the large latitudinal and longitudinal expanse of the State. Increases in mean annual temperature have been greatest in the interior region, and smallest in the State's southwest coastal regions. In general, however, trends point toward increases in both minimum temperatures, and in fewer extreme cold days. Trends in precipitation are somewhat similar to those in temperature, but with more variability. On the whole, Alaska saw a 10-percent increase in precipitation from 1949 to 2005, with the greatest increases recorded in winter. The National Climate Assessment has designated two well-established scenarios developed by the Intergovernmental Panel on Climate Change (Nakicenovic and others, 2001) as a minimum set that technical and author teams considered as context in preparing portions of this assessment. These two scenarios are referred to as the Special Report on Emissions Scenarios A2 and B1 scenarios, which assume either a continuation of recent trends in fossil fuel use (A2) or a vigorous global effort to reduce fossil fuel use (B1). Temperature increases from 4 to 22°F are predicted (to 2070-2099) depending on which emissions scenario (A2 or B1) is used with the least warming in southeast Alaska and the greatest in the northwest. Concomitant with temperature changes, by the end of the 21st century the growing season is expected

  13. Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders

    Directory of Open Access Journals (Sweden)

    David Vállez García

    2016-08-01

    Full Text Available There is increasing evidence of central hyperexcitability in chronic whiplash-associated disorders (cWAD. However, little is known about how an apparently simple cervical spine injury can induce changes in cerebral processes. The present study was designed (1 to validate previous results showing alterations of regional cerebral blood flow (rCBF in cWAD, (2 to test if central hyperexcitability reflects changes in rCBF upon non-painful stimulation of the neck, and (3 to verify our hypothesis that the missing link in understanding the underlying pathophysiology could be the close interaction between the neck and midbrain structures. For this purpose, alterations of rCBF were explored in a case-control study using H215O positron emission tomography, where each group was exposed to four different conditions, including rest and different levels of non-painful electrical stimulation of the neck. rCBF was found to be elevated in patients with cWAD in the posterior cingulate and precuneus, and decreased in the superior temporal, parahippocampal, and inferior frontal gyri, the thalamus and the insular cortex when compared with rCBF in healthy controls. No differences in rCBF were observed between different levels of electrical stimulation. The alterations in regions directly involved with pain perception and interoceptive processing indicate that cWAD symptoms might be the consequence of a mismatch during the integration of information in brain regions involved in pain processing.

  14. Financing geothermal resource development in the Pacific Region states

    Energy Technology Data Exchange (ETDEWEB)

    1978-08-15

    State and federal tax treatment as an incentive to development and non-tax financial incentives such as: the federal geothermal loan guarantee program, the federal geothermal reservoir insurance, and state financial incentives are discussed. (MHR)

  15. Extended HLA-D region haplotype associated with celiac disease

    International Nuclear Information System (INIS)

    Howell, M.D.; Smith, J.R.; Austin, R.K.; Kelleher, D.; Nepom, G.T.; Volk, B.; Kagnoff, M.F.

    1988-01-01

    Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class II markers of the known HLA-linked diseases. This association is primarily with the class II serologic specificities HLA-DR3 and -DQw2. The authors previously described a restriction fragment length polymorphism (RFLP) characterized by the presence of a 4.0-kilobase Rsa I fragment derived from an HLA class II β-chain gene, which distinguishes the class II HLA haplotype of celiac disease patients from those of many serologically matched controls. They now report the isolation of this β-chain gene from a bacteriophage genomic library constructed from the DNA of a celiac disease patient. Based on restriction mapping and differential hybridization with class II cDNA and oligonucleotide probes, this gene was identified as one encoding an HLA-DP β-chain. This celiac disease-associated HLA-DP β-chain gene was flanked by HLA-DP α-chain genes and, therefore, was probably in its normal chromosomal location. The HLA-DPα-chain genes of celiac disease patients also were studied by RFLP analysis. Celiac disease is associated with a subset of HLA-DR3, -DQw2 haplotypes characterized by HLA-DP α- and β-chain gene RFLPs. Within the celiac-disease patient population, the joint segregation of these HLA-DP genes with those encoding the serologic specificities HLA-DR3 and -DQw2 indicates: (i) that the class II HLA haplotype associated with celiac disease is extended throughout the entire HLA-D region, and (ii) that celiac-disease susceptibility genes may reside as far centromeric on this haplotype as the HLA-DP subregion

  16. Extended HLA-D region haplotype associated with celiac disease

    Energy Technology Data Exchange (ETDEWEB)

    Howell, M.D.; Smith, J.R.; Austin, R.K.; Kelleher, D.; Nepom, G.T.; Volk, B.; Kagnoff, M.F.

    1988-01-01

    Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class II markers of the known HLA-linked diseases. This association is primarily with the class II serologic specificities HLA-DR3 and -DQw2. The authors previously described a restriction fragment length polymorphism (RFLP) characterized by the presence of a 4.0-kilobase Rsa I fragment derived from an HLA class II ..beta..-chain gene, which distinguishes the class II HLA haplotype of celiac disease patients from those of many serologically matched controls. They now report the isolation of this ..beta..-chain gene from a bacteriophage genomic library constructed from the DNA of a celiac disease patient. Based on restriction mapping and differential hybridization with class II cDNA and oligonucleotide probes, this gene was identified as one encoding an HLA-DP ..beta..-chain. This celiac disease-associated HLA-DP ..beta..-chain gene was flanked by HLA-DP ..cap alpha..-chain genes and, therefore, was probably in its normal chromosomal location. The HLA-DP..cap alpha..-chain genes of celiac disease patients also were studied by RFLP analysis. Celiac disease is associated with a subset of HLA-DR3, -DQw2 haplotypes characterized by HLA-DP ..cap alpha..- and ..beta..-chain gene RFLPs. Within the celiac-disease patient population, the joint segregation of these HLA-DP genes with those encoding the serologic specificities HLA-DR3 and -DQw2 indicates: (i) that the class II HLA haplotype associated with celiac disease is extended throughout the entire HLA-D region, and (ii) that celiac-disease susceptibility genes may reside as far centromeric on this haplotype as the HLA-DP subregion.

  17. Palo Verde Nuclear Generating Station: an example of the state role in regional nuclear projects

    International Nuclear Information System (INIS)

    Pasternak, A.

    1980-10-01

    A nuclear power plant siting policy which confines new construction to existing sites will lead to the formation of large regional power centers, each involving many utilities from several states. The Palo Verde Nuclear Project in Arizona has been examined in terms of the role state regulation plays in large regional nuclear projects. State regulatory processes do not reflect the regional nature of large power centers. Decisions and actions by individual state regulatory commissions create risk and uncertainty for all the utility participants in regional projects. A climate and mechanism to encourage and facilitate interstate cooperation are needed to enhance the viability of the confined siting policy and the regional power center concept

  18. The Role of the State of the Autonomous Regions

    DEFF Research Database (Denmark)

    Humlebæk, Carsten

    This study focuses on the Statute-related parliamentary debates of the Catalan and Valencian autonomous regions and analyses the conceptions of the political communities defended by the political parties, both of Spain and of the autonomous region in question and the relationship between them. Th...

  19. Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders.

    Science.gov (United States)

    Vállez García, David; Doorduin, Janine; Willemsen, Antoon T M; Dierckx, Rudi A J O; Otte, Andreas

    2016-08-01

    There is increasing evidence of central hyperexcitability in chronic whiplash-associated disorders (cWAD). However, little is known about how an apparently simple cervical spine injury can induce changes in cerebral processes. The present study was designed (1) to validate previous results showing alterations of regional cerebral blood flow (rCBF) in cWAD, (2) to test if central hyperexcitability reflects changes in rCBF upon non-painful stimulation of the neck, and (3) to verify our hypothesis that the missing link in understanding the underlying pathophysiology could be the close interaction between the neck and midbrain structures. For this purpose, alterations of rCBF were explored in a case-control study using H2(15)O positron emission tomography, where each group was exposed to four different conditions, including rest and different levels of non-painful electrical stimulation of the neck. rCBF was found to be elevated in patients with cWAD in the posterior cingulate and precuneus, and decreased in the superior temporal, parahippocampal, and inferior frontal gyri, the thalamus and the insular cortex when compared with rCBF in healthy controls. No differences in rCBF were observed between different levels of electrical stimulation. The alterations in regions directly involved with pain perception and interoceptive processing indicate that cWAD symptoms might be the consequence of a mismatch during the integration of information in brain regions involved in pain processing. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  20. Conditional expectations associated with quantum states

    International Nuclear Information System (INIS)

    Niestegge, Gerd

    2005-01-01

    An extension of the conditional expectations (those under a given subalgebra of events and not the simple ones under a single event) from the classical to the quantum case is presented. In the classical case, the conditional expectations always exist; in the quantum case, however, they exist only if a certain weak compatibility criterion is satisfied. This compatibility criterion was introduced among others in a recent paper by the author. Then, state-independent conditional expectations and quantum Markov processes are studied. A classical Markov process is a probability measure, together with a system of random variables, satisfying the Markov property and can equivalently be described by a system of Markovian kernels (often forming a semigroup). This equivalence is partly extended to quantum probabilities. It is shown that a dynamical (semi)group can be derived from a given system of quantum observables satisfying the Markov property, and the group generators are studied. The results are presented in the framework of Jordan operator algebras, and a very general type of observables (including the usual real-valued observables or self-adjoint operators) is considered

  1. "Mature Regionalism" and the Genesis of "Functional Projects": "Educational Regionalism" in Small (and Micro-States)

    Science.gov (United States)

    Jules, Tavis D.

    2017-01-01

    This article advances that the movement towards "deeper" Caribbean integration has generated a shift from "immature" regionalism to a "mature" form of regionalism. Thus, mature regionalism, a new governance mechanism, in regulating the institutional and legal framework of Caribbean Single Market and Economy is…

  2. 40 CFR 81.76 - State of Hawaii Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false State of Hawaii Air Quality Control... PROGRAMS (CONTINUED) DESIGNATION OF AREAS FOR AIR QUALITY PLANNING PURPOSES Designation of Air Quality Control Regions § 81.76 State of Hawaii Air Quality Control Region. The State of Hawaii Air Quality...

  3. Bipolar disorder and the pseudoautosomal region: An association study

    Energy Technology Data Exchange (ETDEWEB)

    Parsian, A.; Todd, R.D. [Washington Univ. School of Medicine, St. Louis, MO (United States)

    1994-03-15

    From family, adoption, and twin studies it is clear that genetic factors play an important role in the etiology of bipolar disorder (McGuffin and Katz: The Biology of Depression, Gaskell, London, 1986). Recently Yoneda et al. reported an association between an allele (A4) of a VNTR marker (DXYS20) for the pseudoautosomal region and bipolar disorder in a Japanese population. In order to test for this association in a Caucasian population, we have typed a sample of 52 subjects with bipolar disorder and 61 normal controls. The bipolar subjects are probands of multiple incidence families. The normal controls are an epidemiologically ascertained sample of middle-aged, unrelated individuals. The two groups were matched for sex and ethnic background. There were no significant differences in the allele or genotype frequencies of DXYS20 between the two groups. In particular, there was no significant difference in the frequency of the A4 allele in normal controls and bipolar patients (0.377 vs. 0.317, respectively). The prevalence of the A4 allele in bipolar patients and normal controls was 0.567 and 0.622, respectively. We were not able to replicate the results of the 1992 Yoneda et al. study. 15 refs., 2 tabs.

  4. Host state screening process: Regional management plan: [Final report

    International Nuclear Information System (INIS)

    Drobny, N.L.

    1986-01-01

    This report discusses the procedure and cirteria that the Commission selected for designating a host state, should a state not volunteer for this role. Section 2 describes the wide range of approaches considered. Advantages and disadvantages of each are reviewed briefly, and the overall timetable established by the Commission for host state selection is presented. Section 3 describes the selected process for host state designation which involves emphasis on waste quantities generated and transportation factors. Section 4 presents relevant data on characteristics of wastes presently generated and presents estimates for future waste generation to Year 2015. Section 5 presents the results of transportation analyses considering the distance over which waste would be transported and safety (accident) statistics for waste transport routes. Section 6 integrates the conclusions from the analysis of waste volumes generated and transportation factors and suggests how these results might be used to designate a host state. 11 refs., 6 figs., 9 tabs

  5. Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states.

    Science.gov (United States)

    Takeuchi, Hikaru; Taki, Yasuyuki; Sekiguchi, Atsushi; Nouchi, Rui; Kotozaki, Yuka; Nakagawa, Seishu; Miyauchi, Carlos Makoto; Iizuka, Kunio; Yokoyama, Ryoichi; Shinada, Takamitsu; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Kunitoki, Keiko; Sassa, Yuko; Kawashima, Ryuta

    2017-03-01

    Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.

  6. Report on state of the environment of the Banska Bystrica region to 2002

    International Nuclear Information System (INIS)

    Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Bysicka, L.; Gajdos, L.; Goryczkova, A.; Gustafikova, T.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Marcinatova, L.; Proksa, P.; Rolkova, M.; Vagasky, V.; Rolkova, M.

    2003-01-01

    The report on state of environment of the Banska Bystrica region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment and endangered regions; Reasons and consequences of the environment; Risk factors in the environment; Environment conservation

  7. Shared Reproductive State Enhances Female Associations in Dolphins

    International Nuclear Information System (INIS)

    Moller, L.M.; Harcourt, R.G.

    2007-01-01

    Female bottle nose dolphins (genus Tursiops) usually associate at moderate level with other females within social clusters called bands or cliques. It has been suggested that reproductive state may play the predominant role in determining associations within female T. truncatus bands. Here, we test the hypothesis that reproductive state correlates with associations of female Indo-Pacific bottle nose dolphins (T. aduncus). We found that females in similar reproductive state, which included females from late pregnancy to the first year of their calves' life or females from early pregnancy to their calves' newborn period, had higher-association coefficients with each other than they did with females in different reproductive states (females with older calves or without calves). This was observed both within and across social clusters suggesting that reproductive state, at least for pregnant females and those with young calves, plays an important role in determining who to associate with. However, a female's most frequent associate was not always with another in similar reproductive state. We suggest that several factors, including reproductive state, may be of importance in determining associations of female bottle nose dolphins

  8. Shared Reproductive State Enhances Female Associations in Dolphins

    Directory of Open Access Journals (Sweden)

    Luciana M. Möller

    2008-01-01

    Full Text Available Female bottlenose dolphins (genus Tursiops usually associate at moderate level with other females within social clusters called bands or cliques. It has been suggested that reproductive state may play the predominant role in determining associations within female T. truncatus bands. Here, we test the hypothesis that reproductive state correlates with associations of female Indo-Pacific bottlenose dolphins (T. aduncus. We found that females in similar reproductive state, which included females from late pregnancy to the first year of their calves' life or females from early pregnancy to their calves' newborn period, had higher-association coefficients with each other than they did with females in different reproductive states (females with older calves or without calves. This was observed both within and across social clusters suggesting that reproductive state, at least for pregnant females and those with young calves, plays an important role in determining who to associate with. However, a female's most frequent associate was not always with another in similar reproductive state. We suggest that several factors, including reproductive state, may be of importance in determining associations of female bottlenose dolphins.

  9. Activization of the state policy on euro-regional cooperation in the sphere of the interstate regional governance

    Directory of Open Access Journals (Sweden)

    V. I. Pak

    2016-09-01

    Research objective is the justification of the need of activization of the state policy on Euro-regional cooperation in the sphere of the interstate regional governance. During the research it is recognized that the realization of the state policy on the basis of the considered principles, tools, functions, factors and methods has to execute a main objective of the interstate regional control which is exercised in the sphere of Euro-regional cooperation and to promote adjustment of close mutually beneficial relations of Ukraine and neighboring states, to increase competitiveness of the Ukrainian territories and the most effective use of capacity of the Ukrainian regions in the course of activity of Euro-regions. Finally, such state policy has to be focused on the maintenance of the sufficient standard of living of the population, on ensuring integrity and unity of the social and economic space of the country, on formation of the conditions of sustainable and industrial and innovative development of regions, which will provide its harmonious integration into the European environment.

  10. Inventory of power plants in the United States. [By state within standard Federal Regions, using county codes

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    The purpose of this inventory of power plants is to provide a ready reference for planners whose focus is on the state, standard Federal region, and/or national level. Thus the inventory is compiled alphabetically by state within standard Federal regions. The units are listed alphabetically within electric utility systems which in turn are listed alphabetically within states. The locations are identified to county level according to the Federal Information Processing Standards Publication Counties and County Equivalents of the States of the United States. Data compiled include existing and projected electrical generation units, jointly owned units, and projected construction units.

  11. Economic impact of industrial wood energy use in the Southeast region of the United States

    International Nuclear Information System (INIS)

    Stephenson, C.D.

    1991-01-01

    More than 1,000 commercial and industrial installations in the Southeast burn wood fuels. Collectively, these facilities consume 44.3 million green tons of fuelwood and 41.7 million tons per year of 'black liquor' residues. Considering the entire direct and indirect impacts of industrial wood energy expenditures as they ripple through the economy, activities associated with the use of industrial wood energy resulted in the production of over 71,000 jobs and $1 billion in personal income for the Southeast region in 1987. In addition, a total of $237 million in State and Federal tax revenues were generated through wood energy related economic activities. Growth projections indicate that by the year 2000, industrial wood energy utilization will generate approximately 97,000 jobs and $1.4 billion in income in the Southeast region

  12. Correctional Facilities, United States, 2015, EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains point features that represent correctional facilities associated with a single NAICS code. Establishment-specific information, except...

  13. A regional modeling framework of phosphorus sources and transport in streams of the southeastern United States

    Science.gov (United States)

    Garcia, Ana Maria.; Hoos, Anne B.; Terziotti, Silvia

    2011-01-01

    We applied the SPARROW model to estimate phosphorus transport from catchments to stream reaches and subsequent delivery to major receiving water bodies in the Southeastern United States (U.S.). We show that six source variables and five land-to-water transport variables are significant (p < 0.05) in explaining 67% of the variability in long-term log-transformed mean annual phosphorus yields. Three land-to-water variables are a subset of landscape characteristics that have been used as transport factors in phosphorus indices developed by state agencies and are identified through experimental research as influencing land-to-water phosphorus transport at field and plot scales. Two land-to-water variables – soil organic matter and soil pH – are associated with phosphorus sorption, a significant finding given that most state-developed phosphorus indices do not explicitly contain variables for sorption processes. Our findings for Southeastern U.S. streams emphasize the importance of accounting for phosphorus present in the soil profile to predict attainable instream water quality. Regional estimates of phosphorus associated with soil-parent rock were highly significant in explaining instream phosphorus yield variability. Model predictions associate 31% of phosphorus delivered to receiving water bodies to geology and the highest total phosphorus yields in the Southeast were catchments with already high background levels that have been impacted by human activity.

  14. Environmental assessment of the Guaratiba region - Rio de Janeiro state

    International Nuclear Information System (INIS)

    Sousa, F.N.C. de; Coelho, M.J.; Amorim, A.S. de; Oliveira, E.P. de

    1994-01-01

    The Brazilian Army Technological Center (CTEx) is located in the region of Guaratiba, adjacent to the Restinga de Marambaia, Baia de Sepetiba and Serra do Mar. As the mangrove vegetation is the most important in this area, it was decided to investigate this rich ecosystem. For such purpose a task force was created including the Instituto de Projetos Especiais (IPE/CTEx) and the Universidade Federal Rural do Rio de Janeiro (UFRRJ) in order to access the bio ecological aspects of the most abundant species of the region. The results will be incorporated to the Environmental Monitoring Program of the Institute. (author). 3 refs, 1 fig, 2 tabs

  15. Differential structural and resting state connectivity between insular subdivisions and other pain-related brain regions.

    Science.gov (United States)

    Wiech, K; Jbabdi, S; Lin, C S; Andersson, J; Tracey, I

    2014-10-01

    Functional neuroimaging studies suggest that the anterior, mid, and posterior division of the insula subserve different functions in the perception of pain. The anterior insula (AI) has predominantly been associated with cognitive-affective aspects of pain, while the mid and posterior divisions have been implicated in sensory-discriminative processing. We examined whether this functional segregation is paralleled by differences in (1) structural and (2) resting state connectivity and (3) in correlations with pain-relevant psychological traits. Analyses were restricted to the 3 insular subdivisions and other pain-related brain regions. Both type of analyses revealed largely overlapping results. The AI division was predominantly connected to the ventrolateral prefrontal cortex (structural and resting state connectivity) and orbitofrontal cortex (structural connectivity). In contrast, the posterior insula showed strong connections to the primary somatosensory cortex (SI; structural connectivity) and secondary somatosensory cortex (SII; structural and resting state connectivity). The mid insula displayed a hybrid connectivity pattern with strong connections with the ventrolateral prefrontal cortex, SII (structural and resting state connectivity) and SI (structural connectivity). Moreover, resting state connectivity revealed strong connectivity of all 3 subdivisions with the thalamus. On the behavioural level, AI structural connectivity was related to the individual degree of pain vigilance and awareness that showed a positive correlation with AI-amygdala connectivity and a negative correlation with AI-rostral anterior cingulate cortex connectivity. In sum, our findings show a differential structural and resting state connectivity for the anterior, mid, and posterior insula with other pain-relevant brain regions, which might at least partly explain their different functional profiles in pain processing. Copyright © 2014 The Authors. Published by Elsevier B.V. All

  16. 77 FR 38509 - Approval and Promulgation of Implementation Plans; South Carolina; Regional Haze State...

    Science.gov (United States)

    2012-06-28

    ... any discrepancies, prior to approval of the State's regional haze SIP. Response 5: The technical... Federal government provides the funds necessary to pay the direct compliance costs incurred by state and...

  17. The Influence of Globalization, Integration and Regionalization Processes on the European States and Regions

    Directory of Open Access Journals (Sweden)

    T V Bazarenko

    2013-12-01

    Full Text Available The article deals with the impact of globalization, regionalization and integration in European countries and regions. It discusses the distinctive features and factors of influence of each of these processes on the European countries and sub national entities.

  18. Law Libraries in the Western Region/State of Nigeria.

    Science.gov (United States)

    Okewusi, Peter Agboola

    1988-01-01

    Reviews the establishment of the Western Regional Ministry of Justice in Nigeria and the subsequent development of law libraries to aid that agency. The functions of the ministry, staffing, and services of the law libraries, and the establishment of a printing office for government publications are described. (5 references) (CLB)

  19. Regional and municipal energetic statistics - Sao Paulo State - 1987

    International Nuclear Information System (INIS)

    1989-01-01

    The main Brazilian energetic information for subsidizing planning studies in regional and municipal level are presented, including data for the year 1987 that represent the sale of the main petroleum by-product and hydrated alcohol and the electricity consumption. (C.G.C.)

  20. State of mid-atlantic region forests in 2000

    Science.gov (United States)

    Kenneth W. Stolte; Barbara L. Conkling; Stephanie Fulton; M. Patricia Bradley

    2012-01-01

    Wet and warm climate, mountainous topography, and deep rich soils produced one of the most magnificent and diverse temperate forests in the world. In 1650 the Mid-Atlantic forests covered 95 percent of the region, but were greatly reduced in 1900 by extensive tree harvesting, and conversion to farms and pastures. Settlement of forests also led to severe wildfires, soil...

  1. Regional Comparative Unit Cost Studies for Maintenance and Operation of Physical Plants in Universities and Colleges in Central States Region and Rocky Mountain Region.

    Science.gov (United States)

    Association of Physical Plant Administrators, Corvallis, OR.

    Presented in this document are data pertaining to maintenance and operations costs at colleges and universities in the central states region and the Rocky Mountain region. The major accounts included in the cost analysis are: (1) physical plant administration, (2) building maintenance, (3) custodial services, (4) utilities, (5) landscape and…

  2. Higher USA State Resident Neuroticism Is Associated With Lower State Volunteering Rates.

    Science.gov (United States)

    McCann, Stewart J H

    2017-12-01

    Highly neurotic persons have dispositional characteristics that tend to precipitate social anxiety that discourages formal volunteering. With the 50 American states as analytical units, Study 1 found that state resident neuroticism correlated highly ( r = -.55) with state volunteering rates and accounted for another 26.8% of the volunteering rate variance with selected state demographics controlled. Study 2 replicated Study 1 during another period and extended the association to college student, senior, secular, and religious volunteering rates. Study 3 showed state resident percentages engaged in other social behaviors involving more familiarity and fewer demands than formal volunteering related to state volunteering rates but not to neuroticism. In Study 4, state resident neuroticism largely accounted statistically for relations between state volunteering rates and state population density, collectivism, social capital, Republican preference, and well-being. This research is the first to show that state resident neuroticism is a potent predictor of state volunteering rates.

  3. Factors associated with exclusive breastfeeding in the Legal Amazon and Northeast regions, Brazil, 2010

    Directory of Open Access Journals (Sweden)

    Alice Cristina Medeiros das Neves

    2014-01-01

    Full Text Available OBJECTIVE: The objective of this study was to identify the factors associated with exclusive breastfeeding in children aged less than six months from the Brazilian Legal Amazon and Northeast regions. METHODS: The study used data from a survey that assessed prenatal and infant (<1 year care in 2010. Sociodemographic, prenatal, delivery, and puerperium care factors with p<0.05 in multivariate analysis were associated with exclusive breastfeeding. RESULTS: For both regions, the prevalence of exclusive breastfeeding decreased with age, which was the main variable associated with early weaning. In the Legal Amazon, exclusive breastfeeding prevailed among: mothers aged 35 years or more; mothers living in state capitals; and mothers who breastfed on the first hour of life. In the Northeast, the probability of exclusive breastfeeding was greater for mothers aged 35 years or more. CONCLUSION: The factors associated with exclusive breastfeeding were child's and mother's age in both regions; and residence location and breastfeeding in the first hour of life in the Legal Amazon, suggesting the need of differentiated strategies for the promotion of exclusive breastfeeding.

  4. Identifying factors associated with the discharge of male State ...

    African Journals Online (AJOL)

    Background: Designated psychiatric facilities are responsible for the care, treatment and reintegration of State patients. ... State patients were associated with being a primary caregiver (p = 0.031) having good insight into illness (p = 0.025) or offence (p = 0.005) and having had multiple successful leaves of absences.

  5. Regional State of the Coast Report - Western Indian Ocean

    CSIR Research Space (South Africa)

    Bosire, J

    2015-12-01

    Full Text Available protected area in Africa, covering more than 4020 square miles. The region continues to explore new and innovative options for managing oceans and coasts. We also recognise the transboundary nature of shared ocean resources, and our governments have... to list, we would like to express sincere appreciations to the: All Contracting Parties to the Nairobi Convention for supporting the focal points and the Governments of Kenya and Mozambique for graciously hosting and supporting capacity building...

  6. STATE-PRIVATE PARTNERSHIP IN REGIONAL DEVELOPMENT: ADVANTAGES AND RISKS

    OpenAIRE

    S.A. Neganov; L.I. Polizhyk

    2008-01-01

    In paper the problem of state and business interaction in main national projects realization is described. Advantages and risks are shown. To raise efficiency of partnership it is offered to optimize a perfection of a legal regime, society’s participation in discussion of the projects and the controlling over their performance.

  7. Regional homogeneity of the resting-state brain activity correlates with individual intelligence.

    Science.gov (United States)

    Wang, Leiqiong; Song, Ming; Jiang, Tianzi; Zhang, Yunting; Yu, Chunshui

    2011-01-25

    Resting-state functional magnetic resonance imaging has confirmed that the strengths of the long distance functional connectivity between different brain areas are correlated with individual differences in intelligence. However, the association between the local connectivity within a specific brain region and intelligence during rest remains largely unknown. The aim of this study is to investigate the relationship between local connectivity and intelligence. Fifty-nine right-handed healthy adults participated in the study. The regional homogeneity (ReHo) was used to assess the strength of local connectivity. The associations between ReHo and full-scale intelligence quotient (FSIQ) scores were studied in a voxel-wise manner using partial correlation analysis controlling for age and sex. We found that the FSIQ scores were positively correlated with the ReHo values of the bilateral inferior parietal lobules, middle frontal, parahippocampal and inferior temporal gyri, the right thalamus, superior frontal and fusiform gyri, and the left superior parietal lobule. The main findings are consistent with the parieto-frontal integration theory (P-FIT) of intelligence, supporting the view that general intelligence involves multiple brain regions throughout the brain. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  8. Challenges Faced by the Lithuanian State from Regional Identities

    Directory of Open Access Journals (Sweden)

    Petras Kalnius

    2007-12-01

    Full Text Available The article examines how a search for identity attempted by Žemaitians (Samogitians, a Lithuanian local cultural group, eventually evolves into the demand that Žemaitian community should be recognised as an autochthonous nation, and Žemaitian dialect – as a separate language, with all implicit rights. Attempts to implement the idea of a self-governed region as a guarantee of reconstruction and protection of Žemaitian identity is the most recent and vivid representation of such proceedings. Since Lithuania’s accession to EU is increasingly perceived as a threat to cultural identity, other local cultural groups also tend to support the idea of self-governed regions. A suggestion that four (4 self-governed regions covering respective local culture distribution areas should be created in Lithuania is promoted. The authors of such demands, due to a multitude of historical, political, and social reasons, still do not have many supporters in central government bodies, and even in local communities, although in Žemaitija their number is greater.

  9. Changes in Area of Timberland in the United States, 1952-2040, By Ownership, Forest Type, Region, and State

    Science.gov (United States)

    Ralph J. Allg; William G. Hohenstein; Brian C. Murray; Robert G. Haight

    1990-01-01

    Area change projections for timberland in the United Steats are provided by region, State, ownership, and forest type.Total timberland area is projected to drop by 21 million acres or 4 percent by the year 2040.

  10. Impaired insula functional connectivity associated with persistent pain perception in patients with complex regional pain syndrome

    Science.gov (United States)

    Jang, Joon Hwan; Lee, Do-Hyeong; Lee, Kyung-Jun; Lee, Won Joon; Moon, Jee Youn; Kim, Yong Chul

    2017-01-01

    Given that the insula plays a contributory role in the perception of chronic pain, we examined the resting-state functional connectivity between the insular cortex and other brain regions to investigate neural underpinnings of persisting perception of background pain in patients with complex regional pain syndrome (CRPS). A total of 25 patients with CRPS and 25 matched healthy controls underwent functional magnetic resonance imaging at rest. With the anterior and posterior insular cortices as seed regions, we compared the strength of the resting-state functional connectivity between the two groups. Functional connectivity between the anterior and posterior insular cortices and the postcentral and inferior frontal gyri, cingulate cortices was reduced in patients with CRPS compared with controls. Additionally, greater reductions in functional connectivity between the anterior insula and right postcentral gyrus were associated with more severe sensory pain in patients with CRPS (short-form McGill Pain Questionnaire sensory subscores, r = -.517, P = .023). The present results imply a possible role of the insula in aberrant processing of pain information in patients with CRPS. The findings suggest that a functional derangement of the connection between one of the somatosensory cortical functions of perception and one of the insular functions of awareness can play a significant role in the persistent experience of regional pain that is not confined to a specific nerve territory. PMID:28692702

  11. Ultrapotassic rocks geology from Salgueiro region, Pernambuco state, Brazil

    International Nuclear Information System (INIS)

    Silva Filho, A.F. da; Guimaraes, I.P.

    1990-01-01

    The Cachoeirinha-Salgueiro belt has Proterozoic age and is located in the Borborema Province, NE Brazil. The ultrapotassic rocks from Salgueiro region intrudes the Cachoeirinha-Salgueiro belt rocks. The ultrapotassics from Salgueiro region constitutes of three units; Serra do Livramento pluton, and two dyke swarms called respectively beige alkali feldspar granites and green alkali feldspar syenite/quartz-syenite. The Serra do Livramento pluton shows E-W direction, boudin shape, width between 0,15 and 2,10 km, and it is intruded into metamorphic rocks and into the Terra Nova complex. Detailed geological mapping at the Serra das Duas Irmas allowed us to establish the dyke swarm chronology. The mapping reveals seven intrusion episodes, into the Terra Nova pluton, of green alkali feldspar syenite/quartz-syenite and five episodes of bege alkali feldspar granite. They alternate between them in space and time, and there are evidence that they were intruded under the tectonic control of the Pernambuco lineament. A systematic whole-rock Rb-Sr geochronology was done in the green alkali feldspar syenite/quartz-syenite, and an age of 514,8 ± 20,3 Ma was obtained. The initial ratio is 0,710615 + 0,000441. The age obtained shows small error and an initial ratio compatible with a strong crustal contamination. (author)

  12. Association between state school nutrition laws and subsequent child obesity.

    Science.gov (United States)

    Palakshappa, Deepak; Fiks, Alexander G; Faerber, Jennifer A; Feudtner, Chris

    2016-09-01

    Many states have enacted laws to improve school nutrition. We tested whether stronger state nutrition laws are associated with subsequently decreased obesity. We conducted a retrospective national multi-year panel data study (analyzed 2014-2016 at the Children's Hospital of Philadelphia). The predictors were 2010 laws regarding 9 nutrition categories from the Classification of Laws Associated with School Students, which grades the strength of state laws (none, weak, or strong). The outcome was weight status (healthy weight, overweight, or obese) in elementary, middle, and high school from the 2011/2012 National Survey of Children's Health. We tested the association between the strength of laws and weight using multinomial logistic regression. To further evaluate our main results, we conducted state-level longitudinal analyses testing the association between competitive food and beverage laws on the change in obesity from 2003-2011. In main analyses of 40,177 children ages 10-17years, we found strong state laws restricting the sale of competitive food and beverages in elementary school (OR: 0.68; 95% CI: 0.48, 0.96) and strong advertising laws across all grades (OR: 0.63; 95% CI: 0.46, 0.86) were associated with reduced odds of obesity. In longitudinal analyses, states with strong competitive food and beverage laws from 2003-2010 had small but significant decreases in obesity, compared to states with no laws. Although further research is needed to determine the causal effect of these laws, this study suggests that strong state laws limiting the sale and advertising of unhealthy foods and beverages in schools are associated with decreased obesity rates. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Report on state of the environment of the Trencin region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Novacky, K.; Slamkova, M.; Vaculcikova, B.; Merka, M.

    2003-01-01

    The report on state of environment of the Trencin region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  14. Report on state of the environment of the Bratislava region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Tvrdon, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Rostannska, Z.; Merka, M.

    2003-01-01

    he report on state of environment of the Bratislava region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  15. Report on state of the environment of the Nitra region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.

    2003-01-01

    The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  16. Report on state of the environment of the Zilina region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Adamkovicova, A.; Barciakova, E.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kosecky, J.; Kralik, A.; Lacuska, M.; Matecek, L.; Rihalova, A.; Merka, M.; Prievoznik, J.

    2003-01-01

    The report on state of environment of the Zilina region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  17. Report on state of the environment of the Trnava region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.

    2003-01-01

    The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  18. Report on state of the environment of the Kosice region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Gehinova, B.; Dzurdzenik, J.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bodova, E.; Bohus, P.; Bracinikova, J.; Bysicka, L.; Dugasova, J.; Gajdos, L.; Gazarek, G.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Kliment, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Matecek, L.; Palgutova, N.; Vagasky, V.; Bysicka, L.; Hajduova, J.; Mierka, M.; Prievoznik, J.

    2003-01-01

    The report on state of environment of the Kosice region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  19. Report on state of the environment of the Presov region to 2002

    International Nuclear Information System (INIS)

    Proksa, P.; Rolkova, M.; Gajdos, L.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Durbakova, Z.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Mudronova, M.; Vagasky, V.; Merka, M.

    2003-01-01

    The report on state of environment of the Presov region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

  20. When Traits Match States: Examining the Associations between Self-Report Trait and State Mindfulness following a State Mindfulness Induction.

    Science.gov (United States)

    Bravo, Adrian J; Pearson, Matthew R; Wilson, Adam D; Witkiewitz, Katie

    2018-02-01

    Previous research has found inconsistent relationships between trait mindfulness and state mindfulness. To extend previous research, we sought to examine the unique associations between self-report trait mindfulness and state mindfulness by levels of meditation experience (meditation-naïve vs. meditation-experienced) and by mindfulness induction (experimentally induced mindful state vs. control group). We recruited 299 college students (93 with previous mindfulness meditation experience) to participate in an experiment that involved the assessment of five facets of trait mindfulness (among other constructs), followed by a mindfulness induction (vs. control), followed by the assessment of state mindfulness of body and mind. Correlational analyses revealed limited associations between trait mindfulness facets and facets of state mindfulness, and demonstrated that a brief mindfulness exercise focused on bodily sensations and the breath elicited higher state mindfulness of body but not state mindfulness of mind. We found significant interactions such that individuals with previous meditation experience and higher scores on the observing facet of trait mindfulness had the highest levels of state mindfulness of body and mind. Among individuals with meditation experience, the strengths of the associations between observing trait mindfulness and the state mindfulness facets increased with frequency of meditation practice. Some other interactions ran counter to expectations. Overall, the relatively weak associations between trait and state mindfulness demonstrates the need to improve our operationalizations of mindfulness, advance our understanding of how to best cultivate mindfulness, and reappraise the ways in which mindfulness can manifest as a state and as a trait.

  1. Analysis of environment state in technogenic region and its threat to public health

    OpenAIRE

    Grishenko S.V.; Grishenko I.I.; Ohotnikova M.V.; Mustafina A.O.; Kudimov P.V.; Mustafin T.A.

    2014-01-01

    The purpose of the research is to give a complex hygienic evaluation of environment state in Donetsk region and to determine the degree of their potential danger to population health. It includes air pollution, water contamination, state of soil. Nearly 43000 samples of air, 32000 drinking water samples and 4500 soil samples were analyzed. Regions with the highest rate of environmental pollution were defined. It was found that the main sources of environment pollution in Donetsk region are fe...

  2. Prediction of the association state of insulin using spectral parameters.

    Science.gov (United States)

    Uversky, Vladimir N; Garriques, Liza Nielsen; Millett, Ian S; Frokjaer, Sven; Brange, Jens; Doniach, Sebastian; Fink, Anthony L

    2003-04-01

    Human insulin exists in different association states, from monomer to hexamer, depending on the conditions. In the presence of zinc the "normal" state is a hexamer. The structural properties of 20 variants of human insulin were studied by near-UV circular dichroism, fluorescence spectroscopy, and small-angle X-ray scattering (SAXS). The mutants showed different degrees of association (monomer, dimers, tetramers, and hexamers) at neutral pH. A correlation was shown between the accessibility of tyrosines to acrylamide quenching and the degree of association of the insulin mutants. The near-UV CD spectra of the insulins were affected by protein association and by mutation-induced structural perturbations. However, the shape and intensity of difference CD spectra, obtained by subtraction of the spectra measured in 20% acetic acid (where all insulin species were monomeric) from the corresponding spectra measured at neutral pH, correlate well with the degree of insulin association. In fact, the near-UV CD difference spectra for monomeric, dimeric, tetrameric, and hexameric insulin are very distinctive, both in terms of intensity and shape. The results show that the spectral properties of the insulins reflect their state of association, and can be used to predict their oligomeric state. Copyright 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 92:847-858, 2003

  3. Strong states in a troubled region: anatomies of a Middle Eastern regional conflict formation

    NARCIS (Netherlands)

    Leenders, R.; Harpviken, K.B.

    2010-01-01

    This article calls for closer attention to the Middle East in the wider debate on the purported rise of new modes of armed conflict following the end of the Cold War, particularly in relation to the notion of ‘regional conflict formations’ (RCFs). In so doing, it presents and analyses three main

  4. Regional mapping for evaluation of energetic alternatives for isolated systems in the Amazon region: the Brazilian state of Amapa

    International Nuclear Information System (INIS)

    Nascimento, Marcos V.G.; Pires, Silvia Helena M.; Lacorte, Ana Castro; Menezes, Paulo Cesar P.; Guimaraes, Ana Paula C.; Santos, Marco Aurelio dos; Nascimento, Jose A.S.; Borges, Jorge Luiz; La Rovere, Emilio

    1999-01-01

    This paper presents the methodology developed for the characterization of regional energy potentials, and evaluation of the utilization viability of the various alternative electric power generation, by using the analysis technology based on Geographic Information Systems (GIS). The paper also presents the first results obtained for the energy mapping of the State of Amapa, Brazil

  5. Mitochondrial control region and GSTP1 polymorphism associated ...

    African Journals Online (AJOL)

    Souvik Ghatak

    2016-02-20

    Feb 20, 2016 ... were identified in urinary bladder cancer samples in GSTP1 gene. These two heteroplasmic ... also develop into a genetic marker of hereditary urinary blad- der cancer. ..... loop region in human colorectal cancer. Dis Colon ...

  6. High-spin states in 136La and possible structure change in the N =79 region

    Science.gov (United States)

    Nishibata, H.; Leguillon, R.; Odahara, A.; Shimoda, T.; Petrache, C. M.; Ito, Y.; Takatsu, J.; Tajiri, K.; Hamatani, N.; Yokoyama, R.; Ideguchi, E.; Watanabe, H.; Wakabayashi, Y.; Yoshinaga, K.; Suzuki, T.; Nishimura, S.; Beaumel, D.; Lehaut, G.; Guinet, D.; Desesquelles, P.; Curien, D.; Higashiyama, K.; Yoshinaga, N.

    2015-05-01

    High-spin states in the odd-odd nucleus 136La, which is located close to the β -stability line, have been investigated in the radioactive-beam-induced fusion-evaporation reaction 124Sn(17N,5 n ). The use of the radioactive beam enabled a highly sensitive and successful search for a new isomer [14+,T1 /2=187 (27 ) ns] in 136La. In the A =130 -140 mass region, no such long-lived isomer has been observed at high spin in odd-odd nuclei. The 136La level scheme was revised, incorporating the 14+ isomer and six new levels. The results were compared with pair-truncated shell model (PTSM) calculations which successfully explain the level structure of the π h11 /2⊗ν h11/2 -1 bands in 132La and 134La. The isomerism of the 14+ state was investigated also by a collective model, the cranked Nilsson-Strutinsky (CNS) model, which explains various high-spin structures in the medium-heavy mass region. It is suggested that a new type of collective structure is induced in the PTSM model by the increase of the number of π g7 /2 pairs, and/or in the CNS model by the configuration change associated with the shape change in 136La.

  7. Scaled equation of state parameters for gases in the critical region

    Science.gov (United States)

    Sengers, J. M. H. L.; Greer, W. L.; Sengers, J. V.

    1976-01-01

    In the light of recent theoretical developments, the paper presents an accurate characterization of anomalous thermodynamic behavior of xenon, helium 4, helium 3, carbon dioxide, steam and oxygen in the critical region. This behavior is associated with long range fluctuations in the system and the physical properties depend primarily on a single variable, namely, the correlation length. A description of the thermodynamic behavior of fluids in terms of scaling laws is formulated, and the two successfully used scaled equations of state (NBS equation and Linear Model parametric equation) are compared. Methods for fitting both equations to experimental equation of state data are developed and formulated, and the optimum fit for each of the two scaled equations of the above gases are presented and the results are compared. By extending the experimental data for the above one-component fluids to partially miscible binary liquids, superfluid liquid helium, ferromagnets and solids exhibiting order-disorder transitions, the principle of universality is concluded. Finally by using this principle, the critical regions for nine additional fluids are described.

  8. Referral Regions for Time-Sensitive Acute Care Conditions in the United States.

    Science.gov (United States)

    Wallace, David J; Mohan, Deepika; Angus, Derek C; Driessen, Julia R; Seymour, Christopher M; Yealy, Donald M; Roberts, Mark M; Kurland, Kristen S; Kahn, Jeremy M

    2018-03-24

    Regional, coordinated care for time-sensitive and high-risk medical conditions is a priority in the United States. A necessary precursor to coordinated regional care is regions that are actionable from clinical and policy standpoints. The Dartmouth Atlas of Health Care, the major health care referral construct in the United States, uses regions that cross state and county boundaries, limiting fiscal or political ownership by key governmental stakeholders in positions to create incentive and regulate regional care coordination. Our objective is to develop and evaluate referral regions that define care patterns for patients with acute myocardial infraction, acute stroke, or trauma, yet also preserve essential political boundaries. We developed a novel set of acute care referral regions using Medicare data in the United States from 2011. For acute myocardial infraction, acute stroke, or trauma, we iteratively aggregated counties according to patient home location and treating hospital address, using a spatial algorithm. We evaluated referral political boundary preservation and spatial accuracy for each set of referral regions. The new set of referral regions, the Pittsburgh Atlas, had 326 distinct regions. These referral regions did not cross any county or state borders, whereas 43.1% and 98.1% of all Dartmouth Atlas hospital referral regions crossed county and state borders. The Pittsburgh Atlas was comparable to the Dartmouth Atlas in measures of spatial accuracy and identified larger at-risk populations for all 3 conditions. A novel and straightforward spatial algorithm generated referral regions that were politically actionable and accountable for time-sensitive medical emergencies. Copyright © 2018 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  9. Investigating the association between social interactions and personality states dynamics.

    Science.gov (United States)

    Gundogdu, Didem; Finnerty, Ailbhe N; Staiano, Jacopo; Teso, Stefano; Passerini, Andrea; Pianesi, Fabio; Lepri, Bruno

    2017-09-01

    The recent personality psychology literature has coined the name of personality states to refer to states having the same behavioural, affective and cognitive content (described by adjectives) as the corresponding trait, but for a shorter duration. The variability in personality states may be the reaction to specific characteristics of situations. The aim of our study is to investigate whether specific situational factors, that is, different configurations of face-to-face interactions, are predictors of variability of personality states in a work environment. The obtained results provide evidence that within-person variability in personality is associated with variation in face-to-face interactions. Interestingly, the effects differ by type and level of the personality states: adaptation effects for Agreeableness and Emotional Stability, whereby the personality states of an individual trigger similar states in other people interacting with them and complementarity effects for Openness to Experience, whereby the personality states of an individual trigger opposite states in other people interacting with them. Overall, these findings encourage further research to characterize face-to-face and social interactions in terms of their relevance to personality states.

  10. Mortality trends and risk of dying from breast cancer in the 32 states and 7 socioeconomic regions of Mexico, 2002-2011

    Directory of Open Access Journals (Sweden)

    Juan Jesús Sánchez-Barriga

    2014-11-01

    Full Text Available Objective. To determine mortality trends from breast cancer in Mexico nationwide, by state, by socioeconomic region, and to establish an association between education, state of residence, and socioeconomic region with mortality from breast cancer in 2002–2011.Methods. Records of mortality associated with breast cancer were obtained. Rates of mortality nationwide, by state, and by socioeconomic region were calculated. The strength of association between states where women resided, socioeconomic regions, and education with mortality from breast cancer was determined.Results. Women who completed elementary school had a higher risk of dying from breast cancer than people with more education [relative risk (RR 2.58, 95% confidence interval (CI 2.49–2.67]. Mexico City had the strongest association with dying from breast cancer as state and as socioeconomic region 7 [Mexico City: RR 3.47, CI95% 2.7-4.46 (2002 and RR 3.33, CI95% 2.66-4.15 (2011 and region 7: RR 3.72, CI 95%: 3.15-4.38 (2002 and RR 2.87, CI 95%: 2.51-3.28 (2011].Conclusions. In Mexico, the raw mortality rates per 100 000 women who died from breast cancer increased. Mortality was higher in women who had elementary school than in those with more education. The strongest association was in Mexico City as state and as region 7. 

  11. FOREST SPECIES EVALUATION IN THE FOREST REGION IN RORAIMA STATE

    Directory of Open Access Journals (Sweden)

    Helio Tonini

    2006-03-01

    Full Text Available This study was carried out to evaluate 19 native and exotic species and to identify potential species for plantation inhomogeneous stands and in agroforestry systems in forest ecosystem in Roraima State. The species were planted from 1997 to 2000.When the objective was sawn wood production the spacing was 4 x 3 m and when the objective was energy and pulp production thespacing was 3 x 2 m. The samples consisted of 9 lines of 9 plants, totaling 81 plants, coming down to 49 useful trees. In each useful treewere measured the DBH (diameter at 1.30 m and total height. The merchantable volume per hectare was obtained with themerchantable form factor determination, through the scaling of two medium trees using the Smalian method. Each species, was alsoevaluated in relation to survival, bole quality, phytossanitary aspects and wind damages.The data analysis indicated as promisingspecies for use in energy, Eucalyptus urograndis; Schizolobium amazonicum as low or medium wood density species for use inveneer production and Bertholettia excelsa as medium to high density for use in sawn timber.

  12. Using Information Systems as Directions of the State Support for the Conditionally Depressive Regions

    Directory of Open Access Journals (Sweden)

    Morhachov Ilya V.

    2017-12-01

    Full Text Available The article is aimed at substantiating the perspectivity of information systems and technologies as a direction of the State support for the conditionally depressive regions. The article clarifies the assumption that an increase in the number of freelancers in region (even evaders from taxation, causes the growth of both the regional enterprises’ revenues and the tax revenues to budgets. Such freelancers become customers of works, services and goods, and, accordingly, employers for other persons who work officially. The State support for the concentration of such persons in the region contributes to reducing the «brain drain» abroad. The article substantiates prospective directions of the State support for the conditionally depressive regions by means of information systems, the basic elements of which are IT-specialists; as well as economic expediency of priority of the State support for the regions with presence of high level of unemployment of working population. The ways of solution of contradictions between the State and the freelancer in the part of payment of taxes and accrual of the insurance period for the future pension have been suggested. The ultimate goal of the State support for the conditionally depressive regions with use of information systems has been defined, which is to achieve the stage of the multiplied effect of growth of income of economic entities and tax revenues to the budget due to the implementation of innovation projects as result of the concentration of IT specialists in region.

  13. Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression.

    Science.gov (United States)

    Liu, Chun-Hong; Ma, Xin; Wu, Xia; Zhang, Yu; Zhou, Fu-Chun; Li, Feng; Tie, Chang-Le; Dong, Jie; Wang, Yong-Jun; Yang, Zhi; Wang, Chuan-Yue

    2013-03-05

    Bipolar disorder patients experiencing a depressive episode (BD-dep) without an observed history of mania are often misdiagnosed and are consequently treated as having unipolar depression (UD), leading to inadequate treatment and poor outcomes. An essential solution to this problem is to identify objective biological markers that distinguish BD-dep and UD patients at an early stage. However, studies directly comparing the brain dysfunctions associated with BD-dep and UD are rare. More importantly, the specificity of the differences in brain activity between these mental disorders has not been examined. With whole-brain regional homogeneity analysis and region-of-interest (ROI) based receiver operating characteristic (ROC) analysis, we aimed to compare the resting-state brain activity of BD-dep and UD patients. Furthermore, we examined the specific differences and whether these differences were attributed to the brain abnormality caused by BD-dep, UD, or both. Twenty-one bipolar and 21 unipolar depressed patients, as well as 26 healthy subjects matched for gender, age, and educational levels, participated in the study. We compared the differences in the regional homogeneity (ReHo) of the BD-dep and UD groups and further identified their pathophysiological abnormality. In the brain regions showing a difference between the BD-dep and UD groups, we further conducted receptive operation characteristic (ROC) analyses to confirm the effectiveness of the identified difference in classifying the patients. We observed ReHo differences between the BD-dep and UD groups in the right ventrolateral middle frontal gyrus, right dorsal anterior insular, right ventral anterior insular, right cerebellum posterior gyrus, right posterior cingulate cortex, right parahippocampal gyrus, and left cerebellum anterior gyrus. Further ROI comparisons and ROC analysis on these ROIs showed that the right parahippocampal gyrus reflected abnormality specific to the BD-dep group, while the right

  14. Indigenous perspectives on depression in rural regions of India and the United States.

    Science.gov (United States)

    Nieuwsma, Jason A; Pepper, Carolyn M; Maack, Danielle J; Birgenheir, Denis G

    2011-11-01

    Depression is a major health concern in India, yet indigenous Indian perspectives on depression have often been disregarded in favor of Western conceptualizations. The present study used quantitative and qualitative measures modeled on the Explanatory Model Interview Catalogue (EMIC) to elicit beliefs about the symptoms, causes, treatments, and stigma associated with depression. Data were collected from 92 students at a university in the Himalayan region of Northern India and from 97 students at a university in the Rocky Mountain region of the United States. U.S. participants in this study were included primarily to approximate a "Western baseline" (in which professional conceptions of depression are predominantly rooted) from which to elucidate Indian perspectives. Compared to U.S. participants, Indian participants were more likely to view restive symptoms (e.g., irritation, anxiety, difficulty thinking) as common features of depression, to view depression as the result of personally controllable causes (e.g., failure), to endorse social support and spiritual reflection or relaxation (e.g., yoga, meditation) as useful means for dealing with depression, and to associate stigma with depression. Efforts aimed at reducing depression among Indians should focus more on implementing effective and culturally acceptable interventions, such as yoga, meditation, and increasing social support.

  15. Classification of economic and legal remedies for the realization of the state regional policy

    Directory of Open Access Journals (Sweden)

    Лілія Сергіївна Тертишна

    2017-09-01

    Full Text Available The article is devoted to the study of the economic and legal mechanism for ensuring the functioning of the state regional policy in Ukraine. The existing legal and regulatory framework on the availability in it necessary and sufficient conceptual apparatus, a list of economic and legal items or the effective implementation of the state regional policy is analyzed. The main defects of the legislation regulating the state regional policy are defined. State regional policy is a fragment of social and economic policies in the scale of its specific administrative units – regions, and in content – by the means of a synthesis of economic and legal methods aimed at solving problems of state investment, innovation, foreign trade, sectoral policies, where the economic and legal means are regarding the economic part of this policy. It was substantiated that the efficiency of national regional policy depends on how successfully the state can combine and integrate all the directions and types of policies and especially their economic and legal means. It is established, that the general means of state regulation are defined in the Commercial Code of Ukraine as a key. However, there is a need to identify and consolidate the entire system of economic and legal means of state regulation that can be applied in the implementation of the state regional policy and to determine the specific implementation mechanisms. It was found that for all state regional policy objects the universal are such economic law enforcement actions as a public-private partnership and special modes of management.

  16. BOVINE NEOSPOROSIS IN CATTLE FARMS FROM THE NORTHERN REGION OF THE STATE OF VERACRUZ, MEXICO

    Directory of Open Access Journals (Sweden)

    Tomás Montiel-Peña

    2011-11-01

    Full Text Available The aim of the study was to determine the presence of antibodies against Neospora caninum and its DNA in blood samples from bovine females from the northern region of the state of Veracruz, Mexico. A cross-sectional epidemiological study was carried out in 13 municipalities, with a sample size of 821 animals. Blood and serum samples were analyzed through ELISA and PCR, respectively. Overall prevalence was 20.8 %; the highest specific prevalences were obtained in breeding cows (27.4 %, crossbred cows (20.9 %, second-calving cows (23.2 %, three year-old cows (20.6 % and cows with abortion history (20 %. The risk factors associated with seropositivity were dairy cattle (OR = 1.9; IC95 %: 1.1-3.4 and dog presence in the farms (OR = 5.3; IC95 %: 1.3-22.3. The presence of N. caninum DNA was demonstrated in 4 out of 12 blood samples tested, which evidenced the existence of active infection. In conclusion, there were risk factors associated with bovine neosporosis, which proved the existence of active infection by N. caninum in cows from the state of Veracruz, Mexico.

  17. Diversity of United States medical students by region compared to US census data

    Directory of Open Access Journals (Sweden)

    Smith MM

    2015-05-01

    Full Text Available Mark M Smith,1 Steven H Rose,1 Darrell R Schroeder,2 Timothy R Long1 1Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN, USA; 2Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA Purpose: Increasing the diversity of the United States (US physician workforce to better represent the general population has received considerable attention. The purpose of this study was to compare medical student race data to that of the US general population. We hypothesized that race demographics of medical school matriculants would reflect that of the general population. Patients and methods: Published race data from the United States Census Bureau (USCB 2010 census and the 2011 Association of American Medical Colleges (AAMC allopathic medical school application and enrollment by race and ethnicity survey were analyzed and compared. Race data of enrolled medical students was compared to race data of the general population within geographic regions and subregions. Additionally, race data of medical school applicants and matriculants were compared to race data of the overall general population. Results: Race distribution within US medical schools was significantly different than race distribution for the overall, regional, and subregional populations of the US (P<0.001. Additionally, the overall race distribution of medical school applicants differed significantly to the race distribution of the general population (P<0.001. Conclusion: This study demonstrated that race demographics of US medical school applicants and matriculants are significantly different from that of the general population, and may be resultant of societal quandaries present early in formal education. Initiatives targeting underrepresented minorities at an early stage to enhance health care career interest and provide academic support and mentorship will be required to address the racial disparity that exists in US

  18. Examining the interlinkages between regional infrastructure disparities, economic growth, and poverty: A case of Indian states

    Directory of Open Access Journals (Sweden)

    Chotia Varun

    2015-01-01

    Full Text Available This paper investigates the interlinkages between regional infrastructure disparities, economic growth, and poverty in the 21 major Indian States. An overall comprehensive index of infrastructure, the Composite Infrastructure Index (CII, is calculated for each Indian state using the Principal Component Analysis technique. In order to analyse the regional disparities between states in terms of infrastructure, they are ranked based on the calculated CII. We extend our analysis by evaluating the inter-relationship between the Composite Infrastructure Index, Per Capita Net State Domestic Product (PCNSDP, and poverty. The empirical analysis also proves that composite infrastructural growth and economic growth go hand in hand.

  19. Automatic Regionalization Algorithm for Distributed State Estimation in Power Systems: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Dexin; Yang, Liuqing; Florita, Anthony; Alam, S.M. Shafiul; Elgindy, Tarek; Hodge, Bri-Mathias

    2016-08-01

    The deregulation of the power system and the incorporation of generation from renewable energy sources recessitates faster state estimation in the smart grid. Distributed state estimation (DSE) has become a promising and scalable solution to this urgent demand. In this paper, we investigate the regionalization algorithms for the power system, a necessary step before distributed state estimation can be performed. To the best of the authors' knowledge, this is the first investigation on automatic regionalization (AR). We propose three spectral clustering based AR algorithms. Simulations show that our proposed algorithms outperform the two investigated manual regionalization cases. With the help of AR algorithms, we also show how the number of regions impacts the accuracy and convergence speed of the DSE and conclude that the number of regions needs to be chosen carefully to improve the convergence speed of DSEs.

  20. Climate change/variability science and adaptive strategies for state and regional transportation decision making.

    Science.gov (United States)

    2010-04-01

    The objective of this study was to generate a baseline understanding of current policy responses to climate : change/variability at the state and regional transportation-planning and -decision levels. Specifically, : researchers were interested in th...

  1. Idle reduction assessment for the New York State Department of Transportation region 4 fleet.

    Science.gov (United States)

    2015-03-01

    Energetics Incorporated conducted a study to evaluate the operational, economic, and environmental impacts of advanced technologies to reduce idling in : the New York State Department of Transportation (NYSDOT) Region 4 fleet without compromising fun...

  2. U.S. Department of Energy Regional Resource Centers Report: State of the Wind Industry in the Regions

    Energy Technology Data Exchange (ETDEWEB)

    Baranowski, Ruth [National Renewable Energy Lab. (NREL), Golden, CO (United St; Oteri, Frank [National Renewable Energy Lab. (NREL), Golden, CO (United St; Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United St; Tegen, Suzanne [National Renewable Energy Lab. (NREL), Golden, CO (United St

    2016-03-01

    The wind industry and the U.S. Department of Energy (DOE) are addressing technical challenges to increasing wind energy's contribution to the national grid (such as reducing turbine costs and increasing energy production and reliability), and they recognize that public acceptance issues can be challenges for wind energy deployment. Wind project development decisions are best made using unbiased information about the benefits and impacts of wind energy. In 2014, DOE established six wind Regional Resource Centers (RRCs) to provide information about wind energy, focusing on regional qualities. This document summarizes the status and drivers for U.S. wind energy development on regional and state levels. It is intended to be a companion to DOE's 2014 Distributed Wind Market Report, 2014 Wind Technologies Market Report, and 2014 Offshore Wind Market and Economic Analysis that provide assessments of the national wind markets for each of these technologies.

  3. The management of the state reserving system in the aspect of the regional economic security supporting

    Directory of Open Access Journals (Sweden)

    Aleksandr Yefimovich Zemskov

    2011-06-01

    Full Text Available This paper reviews the role of the state material reserve system to ensure economic security of the region. A classification of reserves ensuring economic security of the region was elaborated. A scheme of systematic and structural representation of the state material reserve in order to improve the economic security of the region was suggested. Optimization of operational control of the territorial offices, factories, and settlements of custody within the framework of the state material reserve is one of the most effective instruments to enhance the functioning of the whole system. To solve the problem of technological processes optimization of products acquisition and storage in manufacturings, plants and points of consignment storage of the state material reserve, a static economic-mathematical model was developed. The results can be used to develop appropriate computer systems for support of effective management decisions in the system of state of material reserve.

  4. Integrated Scenarios of Regional Development in Two Semi-Arid States of North-Eastern Brazil

    NARCIS (Netherlands)

    Döll, Petra; Krol, Martinus S.

    2002-01-01

    Scenario analysis of the future is an important tool for supporting sustainability-oriented regional planning. To assist regional planning in two federal states in semi-arid North-eastern Brazil, Ceará and Piauí, we developed integrated qualitative¿quantitative scenarios that show potential

  5. Using Information Systems as Directions of the State Support for the Conditionally Depressive Regions

    OpenAIRE

    Morhachov Ilya V.

    2017-01-01

    The article is aimed at substantiating the perspectivity of information systems and technologies as a direction of the State support for the conditionally depressive regions. The article clarifies the assumption that an increase in the number of freelancers in region (even evaders from taxation), causes the growth of both the regional enterprises’ revenues and the tax revenues to budgets. Such freelancers become customers of works, services and goods, and, accordingly, employers for other per...

  6. Groundwater availability in the United States: the value of quantitative regional assessments

    Science.gov (United States)

    Dennehy, Kevin F.; Reilly, Thomas E.; Cunningham, William L.

    2015-01-01

    The sustainability of water resources is under continued threat from the challenges associated with a growing population, competing demands, and a changing climate. Freshwater scarcity has become a fact in many areas. Much of the United States surface-water supplies are fully apportioned for use; thus, in some areas the only potential alternative freshwater source that can provide needed quantities is groundwater. Although frequently overlooked, groundwater serves as the principal reserve of freshwater in the US and represents much of the potential supply during periods of drought. Some nations have requirements to monitor and characterize the availability of groundwater such as the European Union’s Water Framework Directive (EPCEU 2000). In the US there is no such national requirement. Quantitative regional groundwater availability assessments, however, are essential to document the status and trends of groundwater availability for the US and make informed water-resource decisions possible now and in the future. Barthel (2014) highlighted that the value of regional groundwater assessments goes well beyond just quantifying the resource so that it can be better managed. The tools and techniques required to evaluate these unique regional systems advance the science of hydrogeology and provide enhanced methods that can benefit local-scale groundwater investigations. In addition, a significant, yet under-utilized benefit is the digital spatial and temporal data sets routinely generated as part of these studies. Even though there is no legal or regulatory requirement for regional groundwater assessments in the US, there is a logical basis for their implementation. The purpose of this essay is to articulate the rationale for and reaffirm the value of regional groundwater assessments primarily in the US; however, the arguments hold for all nations. The importance of the data sets and the methods and model development that occur as part of these assessments is stressed

  7. Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders

    NARCIS (Netherlands)

    Vállez García, David; Doorduin, Janine; Willemsen, Antoon T.M.; Dierckx, Rudi A.j.o.; Otte, Andreas

    There is increasing evidence of central hyperexcitability in chronic whiplash-associated disorders (cWAD). However, little is known about how an apparently simple cervical spine injury can induce changes in cerebral processes. The present study was designed (1) to validate previous results showing

  8. An ethnobotanical survey of medicinal and edible plants of Yalo Woreda in Afar regional state, Ethiopia.

    Science.gov (United States)

    Teklehaymanot, Tilahun

    2017-07-05

    The Afar people inhabit the sub-arid and arid part of Ethiopia. Recurrent drought and invasive encroaching plants are taking out plants that have cultural importance, and threaten the biodiversity and the associated traditional knowledge. Thus, the aim of the current study is to conduct an ethnobotanical survey and document medicinal and edible plants in Yalo Woreda in Afar regional state. A cross-sectional ethnobotanical study was carried out in eight kebeles of Yalo Woreda from October 2015 to December 2016. One hundred sixty informants were selected using purposive sampling. The data on diseases, medicinal and edible plants were collected using semi-structure interview and group discussion. The statistical methods, informant consensus factor, fidelity level, and preference ranking were conducted to analyze the data. One hundred and six plants were reported; gender and age differences had implication on the number of plants reported by informants. The knowledge of medicinal plants among informants of each kebele was not different (p medicinal and edible plants affects the traditional use of plants in the Yalo Woreda. The conservation of the plants in the home garden and natural habitat and integration of edible plants into agroforestry development programs in sub-arid and arid regions has to be encouraged to conserve plants of medical and economic importance.

  9. Electroproduction of associated two-body final states

    International Nuclear Information System (INIS)

    Harding, D.J.

    1983-01-01

    The Large Aperture Magnet Experiment at the Cornell Electron Synchrotron measured electron scattering in the region 2.98 2 and 0.5 2 2 . The 11.5 GeV extracted electron beam struck a liquid hydrogen target in an eight kilogauss magnetic field. The charged particles in the final state were tracked through the field by a multiwire proportional chamber system of 34 planes. A lead-scintillator shower counter triggered the experiment on detection of a scattered electron. Time-of-flight and water Cherenkov counters identified some of the final state hadrons. The data recorded on tape was then passed through computer programs which linked proportional chamber strikes into tracks, fit momenta to the tracks, applied particle identification algorithms, selected interesting events, and plotted histograms of invariant masses. All of this is described here in detail, with special attention to the front-end electronics and the track-finding program. Many specific final states were observed. The analysis presented here concentrates on the reaction γ/sub v/p→pπ + ππ 0 , with the final hadrons resulting from the decay of a two-body state. The states pω 0 and p eta 0 are measured. Limits are set for the production of Δ + + rho - , Δ + rho 0 , and Δp + . The conclusion the author draws is that hadron-like two-body processes are almost completely absent in virtual photon scattering in this kinematic region. Vector meson production, excitation of the nucleons, and the scattering of the photons directly from individual partons are the important processes

  10. 77 FR 76871 - Approval and Promulgation of Implementation Plans; State of Colorado; Regional Haze State...

    Science.gov (United States)

    2012-12-31

    ... or rational explanation for how it considered the five factors within the context of this threshold... not better than BART. According to commenters, given that 40 CFR 51.308(e)(2)(C) requires states to...

  11. Cubic Plus Association Equation of State for Flow Assurance Projects

    DEFF Research Database (Denmark)

    dos Santos, Leticia Cotia; Abunahman, Samir Silva; Tavares, Frederico Wanderley

    2015-01-01

    Thermodynamic hydrate inhibitors such as methanol, ethanol, (mono) ethylene glycol (MEG), and triethylene glycol (TEG) are widely used in the oil and gas industry. On modeling these compounds, we show here how the CPA equation of state was implemented in an in-house process simulator as an in......-built model: To validate the implementation, we show calulations for binary systems containing hydrate inhibitors and water or hydrocarbons using the Cubic Plus Association (CPA) and Soave-Redlich-Kwong (SRK) equation of states, also comparing against experimental data. For streams containing natural gas...

  12. 77 FR 27671 - State of Hawaii; Regional Haze Federal Implementation Plan

    Science.gov (United States)

    2012-05-11

    ... High School in the Cafeteria, 155 W. Kawili St., Hilo, Hawaii 96720. To provide opportunities for... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R09-OAR-2012-0345; FRL-9671-2] State of Hawaii... and June 1, 2012 for the proposed rule, ``State of Hawaii; Regional Haze Federal Implementation Plan...

  13. Regional pest suppression associated with widespread Bt maize adoption benefits vegetable growers.

    Science.gov (United States)

    Dively, Galen P; Venugopal, P Dilip; Bean, Dick; Whalen, Joanne; Holmstrom, Kristian; Kuhar, Thomas P; Doughty, Hélène B; Patton, Terry; Cissel, William; Hutchison, William D

    2018-03-27

    Transgenic crops containing the bacterium Bacillus thuringiensis (Bt) genes reduce pests and insecticide usage, promote biocontrol services, and economically benefit growers. Area-wide Bt adoption suppresses pests regionally, with declines expanding beyond the planted Bt crops into other non-Bt crop fields. However, the offsite benefits to growers of other crops from such regional suppression remain uncertain. With data spanning 1976-2016, we demonstrate that vegetable growers benefit via decreased crop damage and insecticide applications in relation to pest suppression in the Mid-Atlantic United States. We provide evidence for the regional suppression of Ostrinia nubilalis (Hübner), European corn borer, and Helicoverpa zea (Boddie), corn earworm, populations in association with widespread Bt maize adoption (1996-2016) and decreased economic levels for injury in vegetable crops [peppers ( Capsicum annuum L.), green beans ( Phaseolus vulgaris L.), and sweet corn ( Zea mays L., convar. saccharata )] compared with the pre-Bt period (1976-1995). Moth populations of both species significantly declined in association with widespread Bt maize (field corn) adoption, even as increased temperatures buffered the population reduction. We show marked decreases in the number of recommended insecticidal applications, insecticides applied, and O. nubilalis damage in vegetable crops in association with widespread Bt maize adoption. These offsite benefits to vegetable growers in the agricultural landscape have not been previously documented, and the positive impacts identified here expand on the reported ecological effects of Bt adoption. Our results also underscore the need to account for offsite economic benefits of pest suppression, in addition to the direct economic benefits of Bt crops.

  14. Water quality issues associated with agricultural drainage in semiarid regions

    Science.gov (United States)

    Sylvester, Marc A.

    High incidences of mortality, birth defects, and reproductive failure in waterfowl using Kesterson Reservoir in the San Joaquin Valley, Calif., have occurred because of the bioaccumulation of selenium from irrigation drainage. These circumstances have prompted concern about the quality of agriculture drainage and its potential effects on human health, fish and wildlife, and beneficial uses of water. The U.S. Geological Survey (USGS) and Lawrence Berkeley Laboratory, University of California (Berkeley, Calif.) organized a 1-day session at the 1986 AGU Fall Meeting in San Francisco, Calif., to provide an interdisciplinary forum for hydrologists, geochemists, and aquatic chemists to discuss the processes controlling the distribution, mobilization, transport, and fate of trace elements in source rocks, soils, water, and biota in semiarid regions in which irrigated agriculture occurs. The focus of t h e session was the presentation of research results on the source, distribution, movement, and fate of selenium in agricultural drainage.

  15. Changing patterns in water toxicity associated with current use pesticides in three California agriculture regions.

    Science.gov (United States)

    Anderson, Brian S; Phillips, Bryn M; Voorhees, Jennifer P; Deng, Xin; Geraci, Jeff; Worcester, Karen; Tjeerdema, Ron S

    2018-03-01

    Regulation of agriculture irrigation water discharges in California, USA, is assessed and controlled by its 9 Regional Water Quality Control Boards under the jurisdiction of the California State Water Resources Control Board. Each Regional Water Board has developed programs to control pesticides in runoff as part of the waste discharge requirements implemented through each region's Irrigated Lands Regulatory Program. The present study assessed how pesticide use patterns differ in the Imperial (Imperial County) and the Salinas and Santa Maria (Monterey County) valleys, which host 3 of California's prime agriculture areas. Surface-water toxicity associated with current use pesticides was monitored at several sites in these areas in 2014 and 2015, and results were linked to changes in pesticide use patterns in these areas. Pesticide use patterns appeared to coincide with differences in the way agriculture programs were implemented by the 2 respective Regional Water Quality Control Boards, and these programs differed in the 2 Water Board Regions. Different pesticide use patterns affected the occurrence of pesticides in agriculture runoff, and this influenced toxicity test results. Greater detection frequency and higher concentrations of the organophosphate pesticide chlorpyrifos were detected in agriculture runoff in Imperial County compared to Monterey County, likely due to more rigorous monitoring requirements for growers using this pesticide in Monterey County. Monterey County agriculture runoff contained toxic concentrations of pyrethroid and neonicotinoid pesticides, which impacted amphipods (Hyalella azteca) and midge larvae (Chironomus dilutus) in toxicity tests. Study results illustrate how monitoring strategies need to evolve as regulatory actions affect change in pesticide use and demonstrate the importance of using toxicity test indicator species appropriate for the suite of contaminants in runoff in order to accurately assess environmental risk. Integr

  16. Abnormal regional homogeneity in Parkinson's disease: a resting state fMRI study

    International Nuclear Information System (INIS)

    Li, Y.; Liang, P.; Jia, X.; Li, K.

    2016-01-01

    Aim: To examine the functional brain alterations in Parkinson's disease (PD) by measuring blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals at rest while controlling for the structural atrophy. Materials and methods: Twenty-three PD patients and 20 age, gender, and education level matched normal controls (NC) were included in this study. Resting state fMRI and structural MRI data were acquired. The resting state brain activity was measured by the regional homogeneity (ReHo) method and the grey matter (GM) volume was attained by the voxel-based morphology (VBM) analysis. Two-sample t-test was then performed to detect the group differences with structural atrophy as a covariate. Results: VBM analysis showed GM volume reductions in the left superior frontal gyrus, left paracentral lobule, and left middle frontal gyrus in PD patients as compared to NC. There were widespread ReHo differences between NC and PD patients. Compared to NC, PD patients showed significant alterations in the motor network, including decreased ReHo in the right primary sensory cortex (S1), while increased ReHo in the left premotor area (PMA) and left dorsolateral prefrontal cortex (DLPFC). In addition, a cluster in the left superior occipital gyrus (SOG) also showed increased ReHo in PD patients. Conclusion: The current findings indicate that significant changes of ReHo in the motor and non-motor cortices have been detected in PD patients, independent of age, gender, education level, and structural atrophy. The present study thus suggests ReHo abnormalities as a potential biomarker for the diagnosis of PD and further provides insights into the biological mechanism of the disease. - Highlights: • Functional changes were found in PD patients independent of structural atrophy. • Both increased and decreased ReHo were observed in motor network regions in PD. • Increased ReHo was detected in visual association cortex for PD patients.

  17. Episodic response project: Wet deposition at watersheds in three regions of the eastern United States

    International Nuclear Information System (INIS)

    Barchet, W.R.

    1991-11-01

    During the period from August 1988 to June 1990, wet-only sampling of precipitation was carried out at three Episodic Response Project sites and at one supplemental site. The three watershed sites are Moss Lake, Biscuit Brook, and Linn Run. The supplemental site was the MAP3S site at Pennsylvania State University that characterizes the central group of northern Appalachian streams. The site operators adhered by varying degrees to the sample collection protocol based on the daily sampling protocol of the MAP3S Precipitation Chemistry Network. Sulfate and nitrate ion together accounted for more than 80% of total anions (in μEq/L) in the precipitation at all sites. Wet deposition of sulfate at Moss Lake, Biscuit Brook, Penn State, and Linn Run averaged 223, 230, 253, and 402 mg/m 2 /month, respectively, whereas nitrate wet deposition averaged 197, 195, 160, and 233 mg/m 2 /month, respectively. Sulfate deposition was a factor of 2 to 4 higher in summer than in winter. The seasonal pattern for nitrate deposition was weak; the seasonal contrast was less than a factor of 2.5 at all sites. The association between the wet deposition and precipitation chemistry at the MAP3S monitoring site and the average for the study watersheds was dependent on the distance between the site and watershed and the intervening terrain. Precipitation chemistry at the monitoring site is representative of that at the ERP study watersheds in the Adirondack and Catskill regions and in the south-western group of watersheds in the Appalachian region. High spatial variability in precipitation amounts makes this assumption weaker for wet deposition. Chemical input to watersheds from dry deposition has not been determined at any site but could range from a factor of 0.3 to 1.0 of the wet deposition. 7 refs., 38 figs., 12 tabs

  18. Integration of national and regional energy development programs in Baltic States

    International Nuclear Information System (INIS)

    Klevas, V.; Antinucci, M.

    2004-01-01

    The report is dedicated to the presentation of the general framework of regional energy planning activities in Baltic States. The objective is to provide information on the context, in which regional energy policy instruments have to operate, and which has to be taken into consideration when compiling energy development measures for regional development and structural funds. The major issue of the publication is to discuss perspective of the formation methodology for energy management integration into development of regional planning documents. The main objective of this publication is to make a brief overview of what are the prospects of regional energy development. The place of municipal and regional energy development programs in general energy investment strategy is defined. The guidelines for regional energy programs are presented

  19. Development of State Interindustry Models for Rocky Mountain Region and California

    Energy Technology Data Exchange (ETDEWEB)

    Sathaye, Jayant A.; Kunin, Leonard

    1976-02-01

    Interindustry tables have been developed for the eight Rocky Mountain States and California. These tables are based on the 367-order 1967 national interindustry table. The national matrix was expanded to 404 sectors by disaggregating the seven minerals industries to 44 industries. The state tables can be used for energy and other resource analysis. Regional impacts of alternate development strategies can be evaluated with their use. A general computer program has been developed to facilitate construction of state interindustry tables.

  20. Convergence problems and energetic regions in π excited states of certain conjugated molecules

    International Nuclear Information System (INIS)

    Giambiagi, M.S. de; Giambiagi, M.; Barros, H.G. de P.L. de.

    1980-01-01

    When calculating π bond orders of excited and superexcited states of conjugated molecules, difficulties arise in applying the variation method; besides, the convergence problems involved are well known. For pyridazine, chosen for discussion, 27 states are considered; the convergence problem is envisaged through two criteria in the choice of a parameter introduced in the compromise Hamiltonian. This convergence parameter is related to the variation method. There exist three particular solutions for bond orders, which divide the 27 states into energetical regions. (Author) [pt

  1. 76 FR 36329 - Approval and Promulgation of Implementation Plans; State of Idaho; Regional Haze State...

    Science.gov (United States)

    2011-06-22

    ... Tier II Operating Permit No. T2-2009-0105, that was included in the Idaho Regional Haze SIP submittal... correctly used dispersion modeling. See 76 FR 1585 and EPA's evaluation of WRAP modeling in EPA's WRAP TSD... which BART eligible sources are subject to BART. EPA's evaluation of BART modeling can be found in the...

  2. Water Footprint of pigs slaughtered in the northeast region of Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Vania Elisabete Schneider

    2016-03-01

    Full Text Available This study estimated the water footprint of pigs slaughtered in the municipalities that participate in the Regional Council for the Development of Serra (Corede Serra, in Portuguese, located in the northeast region of Rio Grande do Sul State, in 2014. In order to determine the water footprint, we estimated the water consumed in the production of grains (corn and soybeans used for animal feed, the water used for livestock watering, the water used for cleaning creation areas and the water consumed by animals during the growing and finishing phases. The total water footprint of slaughtered pigs was 0.19825 km3, the largest component of which was water used for the cultivation of grains (99.6%. The municipality of Nova Prata had the largest water footprint of Corede Serra (0.02343 km3 year1, followed by the municipalities of Paraí (0.02187 km3 year-1 and Serafina Corrêa (0.01658 km3 year-1. The municipalities of São Marcos (0.000006 km3 year-1, Bento Gonçalves (0,00002 km3 year-1 and Boa Vista do Sul (0.0004 km3 year-1 had the lowest water footprints, due to low corn productivity associated with the low number of hogs slaughtered. From this assessment, it was found that the management of water resources associated with pig chain production should include water used in the production of feed grain as well as the water used directly in animal husbandry.

  3. Regional implications of heat flow of the Snake River Plain, Northwestern United States

    Science.gov (United States)

    Blackwell, D. D.

    1989-08-01

    The Snake River Plain is a major topographic feature of the Northwestern United States. It marks the track of an upper mantle and crustal melting event that propagated across the area from southwest to northeast at a velocity of about 3.5 cm/yr. The melting event has the same energetics as a large oceanic hotspot or plume and so the area is the continental analog of an oceanic hotspot track such as the Hawaiian Island-Emperor Seamount chain. Thus, the unique features of the area reflect the response of a continental lithosphere to a very energetic hotspot. The crust is extensively modified by basalt magma emplacement into the crust and by the resulting massive rhyolite volcanism from melted crustal material, presently occurring at Yellowstone National Park. The volcanism is associated with little crustal extension. Heat flow values are high along the margins of the Eastern and Western Snake River Plains and there is abundant evidence for low-grade geothermal resources associated with regional groundwater systems. The regional heat flow pattern in the Western Snake River Plains reflects the influence of crustal-scale thermal refraction associated with the large sedimentary basin that has formed there. Heat flow values in shallow holes in the Eastern Snake River Plains are low due to the Snake River Plains aquifer, an extensive basalt aquifer where water flow rates approach 1 km/yr. Below the aquifer, conductive heat flow values are about 100 mW m -2. Deep holes in the region suggest a systematic eastward increase in heat flow in the Snake River Plains from about 75-90 mW m -2 to 90-110 mW m -2. Temperatures in the upper crust do not behave similarly because the thermal conductivity of the Plio-Pleistocene sedimentary rocks in the west is lower than that in the volcanic rocks characteristic of the Eastern Snake River Plains. Extremely high heat loss values (averaging 2500 mW m -2) and upper crustal temperatures are characteristic of the Yellowstone caldera.

  4. Interactive Development of Regional Climate Web Pages for the Western United States

    Science.gov (United States)

    Oakley, N.; Redmond, K. T.

    2013-12-01

    Weather and climate have a pervasive and significant influence on the western United States, driving a demand for information that is ongoing and constantly increasing. In communications with stakeholders, policy makers, researchers, educators, and the public through formal and informal encounters, three standout challenges face users of weather and climate information in the West. First, the needed information is scattered about the web making it difficult or tedious to access. Second, information is too complex or requires too much background knowledge to be immediately applicable. Third, due to complex terrain, there is high spatial variability in weather, climate, and their associated impacts in the West, warranting information outlets with a region-specific focus. Two web sites, TahoeClim and the Great Basin Weather and Climate Dashboard were developed to overcome these challenges to meeting regional weather and climate information needs. TahoeClim focuses on the Lake Tahoe Basin, a region of critical environmental concern spanning the border of Nevada and California. TahoeClim arose out of the need for researchers, policy makers, and environmental organizations to have access to all available weather and climate information in one place. Additionally, TahoeClim developed tools to both interpret and visualize data for the Tahoe Basin with supporting instructional material. The Great Basin Weather and Climate Dashboard arose from discussions at an informal meeting about Nevada drought organized by the USDA Farm Service Agency. Stakeholders at this meeting expressed a need to take a 'quick glance' at various climate indicators to support their decision making process. Both sites were designed to provide 'one-stop shopping' for weather and climate information in their respective regions and to be intuitive and usable by a diverse audience. An interactive, 'co-development' approach was taken with sites to ensure needs of potential users were met. The sites were

  5. 77 FR 30953 - Approval and Promulgation of State Implementation Plans; State of Wyoming; Regional Haze Rule...

    Science.gov (United States)

    2012-05-24

    ... the 2018 Milestone 7. Special Penalty Provision for 2018 D. ``Better-than-BART'' Demonstration 1. List... Action VII. Statutory and Executive Order Reviews I. General Information A. What should I consider as I... information to better understand how their states and tribes impact Class I areas across the country, and then...

  6. 77 FR 28825 - Approval, Disapproval and Promulgation of State Implementation Plans; State of Utah; Regional...

    Science.gov (United States)

    2012-05-16

    ... Program 6. Provisions for the 2018 Milestone 7. Special Penalty Provision for 2018 D. ``Better-Than-BART... Action VII. Statutory and Executive Order Reviews I. General Information A. What should I consider as I... their states and tribes impact Class I areas across the country, and then pursued the development of...

  7. 77 FR 30248 - Approval and Promulgation of Implementation Plans; State of Idaho; Regional Haze State...

    Science.gov (United States)

    2012-05-22

    ... processing plants; (4) pulp and paper processing; (5) cement manufacturing; (6) sugar beet processing; and (7... additional detail regarding the State's analysis of this source category. Cement manufacturing emits NO X... generate steam or hot water in manufacturing, material processing, mining, refining, and/or electricity...

  8. [Factors associated with early weaning in a Spanish region].

    Science.gov (United States)

    Rius, J M; Ortuño, J; Rivas, C; Maravall, M; Calzado, M A; López, A; Aguar, M; Vento, M

    2014-01-01

    Breastfeeding has undoubtedly great benefits. Previous studies have foundan early dropout. Only a few studies have investigated related factors. Our aim was to find out on-going breastfeeding rates along the first 12 months after birth and analyse factors associated with early weaning. This is a prospective study including consecutive pairs (mother and newborn) till completion of the required sample. Variables were collected performing a structured program of surveys to the mothers. Bivariate and multivariate analysis of the data was performed. A total of 452 pairs were recruited. It was found that 81% of them started breastfeeding, with a prevalence of breastfeeding of 39% and 21% at 3 and 6 months after birth, respectively. Factors associated with early discontinuation of breastfeeding were: pregnancy induced by assisted reproduction methods (OR=5.58; 95% CI: 2.62-11.91), maternal smoking (OR=1.56; 95% CI: 1.10-2.22), poor maternal expectations about the duration of breastfeeding (OR=2.19; 95% CI: 1.49-3.23), use of nipple shields for breastfeeding (OR=2.57; 95% CI: 1.69-3.90), pacifier use on a regular basis during the first month after delivery (OR=1.39; 95% CI: 1.02-1.91), maternal university educational level (OR=0,59; 95% CI: 0,40-0,88), attending birth preparation programs during pregnancy (OR=0,68; 95% CI: 0,49-0,94), and believing having enough milk output at the time of discharge (OR=0,66; 95% CI: 0,47-0,92). International recommendations about duration of breastfeeding are not achieved in our country because of high rates of early weaning. We describe the known factors involved and other novel factors. The implementation of interventions to increase breastfeeding rates and to prevent early weaning are strongly recommended. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  9. Associations Between Antibullying Policies and Bullying in 25 States.

    Science.gov (United States)

    Hatzenbuehler, Mark L; Schwab-Reese, Laura; Ranapurwala, Shabbar I; Hertz, Marci F; Ramirez, Marizen R

    2015-10-01

    Bullying is the most widespread form of peer aggression in schools. In an effort to address school bullying, 49 states have passed antibullying statutes. Despite the ubiquity of these policies, there has been limited empirical examination of their effectiveness in reducing students' risk of being bullied. To evaluate the effectiveness of antibullying legislation in reducing students' risk of being bullied and cyberbullied, using data from 25 states in the United States. A cross-sectional observational study was conducted using a population-based survey of 63 635 adolescents in grades 9 to 12 from 25 states participating in the 2011 Youth Risk Behavior Surveillance System study (September 2010-December 2011). Data on antibullying legislation were obtained from the US Department of Education (DOE), which commissioned a systematic review of state laws in 2011. The report identified 16 key components that were divided into the following 4 broad categories: purpose and definition of the law, district policy development and review, school district policy components (eg, responsibilities for reporting bullying incidents), and additional components (eg, how policies are communicated). Policy variables from 25 states were linked to individual-level data from the Youth Risk Behavior Surveillance System on experiencing bullying and cyberbullying. Analyses were conducted between March 1, 2014, and December 1, 2014. State antibullying legislation. Exposure to bullying and cyberbullying in the past 12 months. There was substantial variation in the rates of bullying and cyberbullying across states. After controlling for relevant state-level confounders, students in states with at least 1 DOE legislative component in the antibullying law had a 24% (95% CI, 15%-32%) reduced odds of reporting bullying and 20% (95% CI, 9%-29%) reduced odds of reporting cyberbullying compared with students in states whose laws had no DOE legislative components. Three individual components of

  10. Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.

    Directory of Open Access Journals (Sweden)

    Qian Xiao

    Full Text Available UNLABELLED: Pediatric bipolar disorder (PBD is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. METHODS: Regional homogeneity (ReHo was examined with resting-state fMRI (RS-fMRI on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. RESULTS: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. CONCLUSIONS: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.

  11. The development and state regional policy in the V4 countries

    Directory of Open Access Journals (Sweden)

    Dominik Pristach

    2016-11-01

    Full Text Available -\tArticle provides an overview of the current state of development of regional policy in the European Union, which compares with developments in the countries of the Rose Group (Slovakia, Czech Republic, Hungary and Poland -\tit informs about the possibilities of regional, structural and cohesion European Union policy -\tobjectives and instruments of regional policy in the programming period 2007 – 2013 -\tWhat is NUTS regions and cohesion. in all countries analyzed evaluates and compares economic regions according to objective level verifiable indicators. They include gross domestic product (GDP in purchasing power parity (PPP 1 per capita and unemployment levels -\twork describes the strategies, objectives, instruments, program and institutional framework of regional policy in individual countries.

  12. Nonresearch Industry Payments to Radiologists: Characteristics and Associations With Regional Medical Imaging Utilization.

    Science.gov (United States)

    Kokabi, Nima; Junn, Jacqueline C; Xing, Minzhi; Hemingway, Jennifer; Hughes, Danny R; Duszak, Richard

    2017-03-01

    To evaluate characteristics of nonresearch industry payments to radiologists and associations with regional diagnostic imaging utilization. Using 2014 CMS Open Payment data, all disclosed nonresearch-related industry payments to radiologists were identified. Health Resources and Services Administration Area Health Resources Files were used to identify actual and population-weighted numbers of radiologists by state. Utilizing the 5% random beneficiary sample CMS Research Identifiable Files from 2014, average Medicare imaging spending per beneficiary in each state was calculated. Average frequency and dollar amounts of nonresearch nonroyalty payments to radiologists were calculated at the state level. Using the Pearson correlation coefficient, the relationship between frequency and amounts of nonresearch payments to radiologists versus per-beneficiary Medicare imaging spending was evaluated at the state level. Overall, 2,008 radiologists (1,670 diagnostic, 338 interventional) received nonresearch nonroyalty payments from industry, representing 5.2% of all 38,857 radiologists nationwide. A total of 4,975 individual transfers translated to 2.5 ± 1.3 discrete payments per receiving radiologist with a mean of $432 ± $1,976 (median $26; range $1-$34,050). Food and beverage expenses constituted the vast majority of disclosed transfers (4,111; 83%), followed by travel and lodging (444; 9%), consulting fees (279; 6%), and educational expenses (51; 1%). Considerable geographic variation in payments was observed, ranging from 0% of radiologists in Vermont to 12.9% in the District of Columbia. No correlation was identified between average per-beneficiary Medicare imaging spending and the proportion of nonresearch-funded radiologists in each state (r = 0.06). Similarly, no correlation was identified between average per-beneficiary Medicare imaging spending and the average nonresearch transfer amount to radiologists in each state (r = -0.08). In 2014, only a small minority of

  13. Frequency-dependent brain regional homogeneity alterations in patients with mild cognitive impairment during working memory state relative to resting state

    Directory of Open Access Journals (Sweden)

    Pengyun eWang

    2016-03-01

    Full Text Available Several studies have reported working memory deficits in patients with mild cognitive impairment (MCI. However, previous studies investigating the neural mechanisms of MCI have primarily focused on brain activity alterations during working memory tasks. No study to date has compared brain network alterations in the working memory state between MCI patients and normal control subjects. Therefore, using the index of regional homogeneity (ReHo, we explored brain network impairments in MCI patients during a working memory task relative to the resting state, and identified frequency-dependent effects in separate frequency bands.Our results indicate that, in MCI patients, ReHo is altered in the posterior cingulate cortex in the slow-3 band (0.073–0.198 Hz, and in the bottom of the right occipital lobe and part of the right cerebellum, the right thalamus, a diffusing region in the bilateral prefrontal cortex, the left and right parietal-occipital regions, and the right angular gyrus in the slow-5 band (0.01–0.027 Hz. Furthermore, in normal controls, the value of ReHo in clusters belonging to the default mode network decreased, while the value of ReHo in clusters belonging to the attentional network increased during the task state. However, this pattern was reversed in MCI patients, and was associated with decreased working memory performance. In addition, we identified altered functional connectivity of the abovementioned regions with other parts of the brain in MCI patients.This is the first study to compare frequency-dependent alterations of ReHo in MCI patients between resting and working memory states. The results provide a new perspective regarding the neural mechanisms of working memory deficits in MCI patients, and extend our knowledge of altered brain patterns in resting and task-evoked states.

  14. Spatial and seasonal patterns in urban influence on regional concentrations of speciated aerosols across the United States

    Science.gov (United States)

    Hand, J. L.; Schichtel, B. A.; Malm, W. C.; Pitchford, M.; Frank, N. H.

    2014-11-01

    Monthly, seasonal, and annual mean estimates of urban influence on regional concentrations of major aerosol species were computed using speciated aerosol data from the rural IMPROVE network (Interagency Monitoring of Protected Visual Environments) and the United States Environmental Protection Agency's urban Chemical Speciation Network for the 2008 through 2011 period. Aggregated for sites across the continental United States, the annual mean and one standard error in urban excess (defined as the ratio of urban to nearby rural concentrations) was highest for elemental carbon (3.3 ± 0.2), followed by ammonium nitrate (2.5 ± 0.2), particulate organic matter (1.78 ± 0.08), and ammonium sulfate (1.23 ± 0.03). The seasonal variability in urban excess was significant for carbonaceous aerosols and ammonium nitrate in the West, in contrast to the low seasonal variability in the urban influence of ammonium sulfate. Generally for all species, higher excess values in the West were associated with localized urban sources while in the East excess was more regional in extent. In addition, higher excess values in the western United States in winter were likely influenced not only by differences in sources but also by combined meteorological and topographic effects. This work has implications for understanding the spatial heterogeneity of major aerosol species near the interface of urban and rural regions and therefore for designing appropriate air quality management strategies. In addition, the spatial patterns in speciated mass concentrations provide constraints for regional and global models.

  15. Response to state comments on the draft regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1984-11-01

    In May, 1983, the US Department of Energy (DOE) Crystalline Repository Project Office (CPO) issued six draft Regional Characterization Reports (RCRs) for review and comment to the 17 Crystalline States comprising the Northeastern, Southeastern, and North Central crystalline regions. Comment letters were received from 13 of the 17 states. The more than 2000 comments generally focused on the quality and content of the characterization reports and on their intended use in region-to-area screening. These comments were paraphrased and grouped into 23 subjects within the following four topical areas: (1) General and Programmatic; (2) Geologic; (3) Environmental and Socioeconomic; and (4) Editorial. This document provides responses to the comments submitted by the states

  16. Association Between State Medical Malpractice Environment and Postoperative Outcomes in the United States.

    Science.gov (United States)

    Minami, Christina A; Sheils, Catherine R; Pavey, Emily; Chung, Jeanette W; Stulberg, Jonah J; Odell, David D; Yang, Anthony D; Bentrem, David J; Bilimoria, Karl Y

    2017-03-01

    The US medical malpractice system assumes that the threat of liability should deter negligence, but it is unclear whether malpractice environment affects health care quality. We sought to explore the association between state malpractice environment and postoperative complication rates. This observational study included Medicare fee-for-service beneficiaries undergoing one of the following operations in 2010: colorectal, lung, esophageal, or pancreatic resection, total knee arthroplasty, craniotomy, gastric bypass, abdominal aortic aneurysm repair, coronary artery bypass grafting, or cystectomy. The state-specific malpractice environment was measured by 2010 medical malpractice insurance premiums, state average award size, paid malpractice claims/100 physicians, and a composite malpractice measure. Outcomes of interest included 30-day readmission, mortality, and postoperative complications (eg sepsis, myocardial infarction [MI], pneumonia). Using Medicare administrative claims data, associations between malpractice environment and postoperative outcomes were estimated using hierarchical logistic regression models with hospital random-intercepts. Measures of malpractice environment did not have significant, consistent associations with postoperative outcomes. No individual tort reform law was consistently associated with improved postoperative outcomes. Higher-risk state malpractice environment, based on the composite measure, was associated with higher likelihood of sepsis (odds ratio [OR] 1.22; 95% CI 1.07 to 1.39), MI (OR 1.14; 95% CI 1.06 to 1.23), pneumonia (OR 1.09; 95% CI 1.03 to 1.16), acute renal failure (OR 1.15; 95% CI 1.08 to 1.22), deep vein thrombosis/pulmonary embolism (OR 1.22; 95% CI 1.13 to 1.32), and gastrointestinal bleed (OR 1.18; 95% CI 1.08 to 1.30). Higher risk malpractice environments were not consistently associated with a lower likelihood of surgical postoperative complications, bringing into question the ability of malpractice lawsuits to

  17. Mathematical models and methods of assisting state subsidy distribution at the regional level

    Science.gov (United States)

    Bondarenko, Yu V.; Azarnova, T. V.; Kashirina, I. L.; Goroshko, I. V.

    2018-03-01

    One of the most common forms of state support in the world is subsidization. By providing direct financial support to businesses, local authorities get an opportunity to set certain performance targets. Successful achievement of such targets depends not only on the amount of the budgetary allocations, but also on the distribution mechanisms adopted by the regional authorities. Analysis of the existing mechanisms of subsidies distribution in Russian regions shows that in most cases the choice of subsidy calculation formula and its parameters depends on the experts’ subjective opinion. The authors offer a new approach to assisting subsidy distribution at the regional level, which is based on mathematical models and methods, allowing to evaluate the influence of subsidy distribution on the region’s social and economic development. The results of calculations were discussed with the regional administration representatives who confirmed their significance for decision-making in the sphere of state control.

  18. Genotype by region and season interactions on weaning weight in United States Angus cattle.

    Science.gov (United States)

    Williams, J L; Lukaszewicz, M; Bertrand, J K; Misztal, I

    2012-10-01

    The objective of this study was to determine if weaning weight performance is genetically consistent across different environments in the United States. The American Angus Association provided weight and pedigree data. Weaning weights observed in the Southeast (SoE) and Northwest (NW) were the focus of this study, as these regions are perceived as opposite extremes in climate. The 2 most represented calving seasons in each region were fall and winter in the SoE and winter and spring in the NW. The original data were edited to remove weaning weight records outside of 3 SD from the respective region-season mean, contemporary groups smaller than 20, and single-sire contemporary groups. The final dataset included 884,465 weaning weight records with 64,907 from fall-born calves in the SoE, 74,820 from winter-born calves in the SoE, 346,724 from winter-born calves in the NW and 398,014 from spring-born calves in the NW. Weaning weights of calves born in different region-season classes adjusted to 205 d of age were considered different but genetically correlated traits in a multivariate analysis. The sole fixed effect was weaning contemporary group and random effects included direct, maternal, maternal permanent environment, and a residual. Direct heritability estimates differed little across environments: 0.31 and 0.35 for weight in fall- and winter-born calves in the SoE, and 0.29 and 0.32 for winter- and spring-born calves in NW. Maternal heritability estimates ranged from 0.12 in the NW to 0.16 the SoE. Genetic correlations spanned from 0.69 to 0.93 among direct effects and from 0.65 to 0.95 among maternal effects. All heritability estimates had small (0.01 to 0.04) SE. The most distinct environments appeared to be winter in SoE and spring in NW (correlations of 0.69 and 0.65 for the direct and maternal effects). Different choices of sires for different environments might be justified to achieve the growth performance expected.

  19. Participation and Neutrality of State Civil Apparatus in Direct Regional Election: Surabaya City Case

    Directory of Open Access Journals (Sweden)

    Catur Wibowo Budi Santoso

    2016-05-01

    Full Text Available In relation to the existence of State Civil Apparatus, at least there are two issues that must be observed in the implementation of Regional elections, namely the issues of participation and neutrality of State Civil Apparatus. The phenomenon that occurs during this time is the involvement of the State Civil Apparatus in attendance is still minimum (low. Moreover, it is believed that there are many Civil Apparatus State who is not neutral in the organization of Regional Elections. In this regard, this study aims to analyze the participation and neutrality of State Civil Apparatus. The method utilized in this study is qualitative. The result of the study shows that in general the participation of State Civil Apparatus in Surabaya is adequately good, but the neutrality of State Civil Apparatus has not implemented well enough. There are at least three (3 main factors influencing the participation of Civil State Apparatus, namely the factors of leadership exemplary, commitment to employees, and employee development. As for the neutrality of the State Civil Apparatus, among others, is influenced by the factors of the ambition of employee, primordialism, and working environment of employees.

  20. State and regional systems of accounting for and control of nuclear materials cooperation between international, regional and states safeguards organizations: An evolving issue

    International Nuclear Information System (INIS)

    Fernández Moreno, Sonia

    2011-01-01

    Cooperation between the IAEA, States and regional organizations is increasingly important to ensure effective accountancy and control of nuclear material in peaceful uses. The IAEA, SAGSI2 and institutions such INMM3 and ESARDA4 have recognized the relevance and the evolving role that SSAC5 and regional organizations play to this aim. In this context, it is important to take steps to ensure the effectiveness of the system and the optimal level of relationship between these organizations so as to maximize the benefits for each party, particularly in those cases where well developed systems exist. Moreover, expansion of nuclear energy requires concerted efforts towards building competence in safeguards in all relevant States. This is also important with respect to other aspects of nonproliferation. In this scenario there is agreement on the need to have effective state organizations that fulfill international safeguards and other security obligations. However, the roles and duties of SSAC and the possible scope of cooperation between the IAEA and SSAC are still under evolution. This paper discusses possible ways and means to build competence in safeguards and how the international community could be more proactive in establishing a framework including the various dimensions of the cooperation in safeguards and other security matters between all parties concerned. The establishment of a forum and a network of interested parties under the auspice of interested organizations could be one mechanism to exchange best practices and experiences. (authors)

  1. Behavioral Determinants of Russian Nuclear State-Owned Enterprises in Central and Eastern European Region

    OpenAIRE

    Vlcek, Tomas; Jirusek, Martin

    2015-01-01

    Rosatom State Nuclear Corporation play a substantial role in the energy sector of the Central and Eastern European region and the behavioral characteristics of the company forms the basis of this article. Rosatom is positioned as the dominant provider of nuclear technology and fuel supplies to the region, in large part stemming from the Soviet legacy in CEE countries. Compounding this challenge, nuclear energy is one of the major sources of power generation in CEE. Given the long-time, near m...

  2. The United States Department of Homeland Security Concept of Regionalization - Will It Survive the Test

    Science.gov (United States)

    2006-09-01

    used to explain in general an individual state’s focus including restrictions on the application of regionalization and the impact of home rule...terrorist attack. Didn’t New York City Mayor Michael Bloomberg exhibit big city egoism over a reduction in homeland security funding? Some...been missed in the turmoil at DHS. Several states have eased legislative restrictions that interfere with regionalization. Indiana for example, has an

  3. Ground-water resources in the tri-state region adjacent to the Lower Delaware River

    Science.gov (United States)

    Barksdale, Henry C.; Greenman, David W.; Lang, Solomon Max; Hilton, George Stockbridge; Outlaw, Donald E.

    1958-01-01

    The purpose of this report is to appraise and evaluate the groundwater resources of a tri-state region adjacent to the lower Delaware River that is centered around Philadelphia, Pa., and Camden, N. J., and includes Wilmington, Del., and Trenton, N.J. Specifically, the region includes New Castle County, Del.; Burlington, Camden, Gloucester, Mercer, and Salem Counties in New Jersey; and Bucks, Chester, Delaware, Montgomery, and Philadelphia Counties in Pennsylvania.

  4. Democratic Republic of Congo A Fertile Ground for Instability in the Great Lakes Region States

    Science.gov (United States)

    2017-06-09

    ravaged by a brutal armed conflict. In comparison to the three past presidents, Joseph Kabila has managed to restore political stability and calm to much...DEMOCRATIC REPUBLIC OF CONGO-A FERTILE GROUND FOR INSTABILITY IN THE GREAT LAKES REGION STATES A thesis presented to the Faculty of...From - To) AUG 2016 – JUNE 2017 4. TITLE AND SUBTITLE Democratic Republic of Congo-A Fertile Ground for Instability in the Great Lakes Region

  5. Factors affecting stream nutrient loads: A synthesis of regional SPARROW model results for the continental United States

    Science.gov (United States)

    Preston, Stephen D.; Alexander, Richard B.; Schwarz, Gregory E.; Crawford, Charles G.

    2011-01-01

    We compared the results of 12 recently calibrated regional SPARROW (SPAtially Referenced Regressions On Watershed attributes) models covering most of the continental United States to evaluate the consistency and regional differences in factors affecting stream nutrient loads. The models - 6 for total nitrogen and 6 for total phosphorus - all provide similar levels of prediction accuracy, but those for major river basins in the eastern half of the country were somewhat more accurate. The models simulate long-term mean annual stream nutrient loads as a function of a wide range of known sources and climatic (precipitation, temperature), landscape (e.g., soils, geology), and aquatic factors affecting nutrient fate and transport. The results confirm the dominant effects of urban and agricultural sources on stream nutrient loads nationally and regionally, but reveal considerable spatial variability in the specific types of sources that control water quality. These include regional differences in the relative importance of different types of urban (municipal and industrial point vs. diffuse urban runoff) and agriculture (crop cultivation vs. animal waste) sources, as well as the effects of atmospheric deposition, mining, and background (e.g., soil phosphorus) sources on stream nutrients. Overall, we found that the SPARROW model results provide a consistent set of information for identifying the major sources and environmental factors affecting nutrient fate and transport in United States watersheds at regional and subregional scales. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

  6. Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women

    NARCIS (Netherlands)

    Georgiadis, Janniko R.; Kortekaas, Rudie; Kuipers, Rutger; Nieuwenburg, Arie; Pruim, Jan; Reinders, A. A. T. Simone; Holstege, Gert

    2006-01-01

    There is a severe lack of knowledge regarding the brain regions involved in human sexual performance in general, and female orgasm in particular. We used [(15)O]-H(2)O positron emission tomography to measure regional cerebral blood flow (rCBF) in 12 healthy women during a nonsexual resting state,

  7. Characterization of Sugarcane Mosaic Virus Scmv1 and Scmv2 Resistance Regions by Regional Association Analysis in Maize.

    Directory of Open Access Journals (Sweden)

    Pengfei Leng

    Full Text Available Sugarcane Mosaic Virus (SCMV causes one of the most severe virus diseases in maize worldwide, resulting in reduced grain and forage yield in susceptible cultivars. In this study, two association panels consisting of 94 inbred lines each, from China and the U.S., were characterized for resistance to two isolates: SCMV-Seehausen and SCMV-BJ. The population structure of both association panels was analyzed using 3072 single nucleotide polymorphism (SNP markers. The Chinese and the U.S. panel were both subdivided into two sub-populations, the latter comprised of Stiff Stalk Synthetic (SS lines and Non Stiff Stalk Synthetic (NSS. The relative kinships were calculated using informative 2947 SNPs with minor allele frequency ≥ 5% and missing data ≤ 20% for the Chinese panel and 2841 SNPs with the same characteristics were used for the U.S. panel. The Scmv1 region was genotyped using 7 single sequence repeat (SSR and sequence-tagged site (STS markers, and 12 SSR markers were used for the Scmv2 region in the U.S. panel, while 5 of them were used for the Chinese panel. For all traits, a MLM (Mix Linear Model controlling both population structure and relative kinship (Q + K was used for association analysis. Three markers Trx-1, STS-11, and STS-12 located in the Scmv1 region were strongly associated (P = 0.001 with SCMV resistance, and explained more than 16.0%, 10.6%, and 19.7% of phenotypic variation, respectively. 207FG003 located in the Scmv2 region was significantly associated (P = 0.001 with SCMV resistance, and explained around 18.5% of phenotypic variation.

  8. Associate Status at CERN for non-European States

    CERN Document Server

    2002-01-01

    On a number of occasions in the past, the Committee of Council has examined proposals to create an Associate Status for non-European States wishing to participate in, and make substantial contributions to, a CERN activity or activities. The immediate purpose of the proposed status was to permit those States to participate in the LHC Project. In 1995, the Committee of Council decided not to follow up the matter at that stage since the mechanism of Co-operation Agreements with individual countries (USA, Japan, Russian Federation etc.) was considered more appropriate. At its meeting of 20 June 2002, the Committee of Council reviewed the proposal prepared by the Working Group appointed by the Committee of Council to examine the question of CERN's enlargement. Taking into account the comments received from the Delegations, the Working Group has finalised its proposal, which is now submitted to the Committee of Council for recommendation to the Council and to the Council for a decision.

  9. Status of photovoltaics in the Newly Associated States

    International Nuclear Information System (INIS)

    Pietruszko, S.M.; Mikolajuk, A.; Fara, L.; Fara, S.; Vitanov, P.; Stratieva, N.; Rehak, J.; Barinka, R.; Mellikov, E.; Palfy, M.; Shipkovs, P.; Krotkus, A.; Saly, V.; Nemac, F.; Swens, J.; Nowak, S.; Zachariou, A.; Fechner, H.; Passiniemi, P.

    2004-01-01

    The Status of Photovoltaics in the Central and Eastern Europe presents the state of the art of photovoltaics (PV) in the Newly Associated States (NAS): Bulgaria, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, Slovenia. The attempt was made to cover all photovoltaics activities in NAS, from research to industry and markets as well as from technology development to dissemination and education. The document covers the following topics and issues: organization of PV research and demonstration activities, stakeholders involved in research and technology development (RTD), scientific potential of NAS PV community, PV activities carried out in NAS countries, PV policies and support mechanisms, achievements and barriers, challenges and needs to the development of PV in the NAS. (authors)

  10. Current state and development trends of the agroindustrial complex and rural territories of Perm Region

    Directory of Open Access Journals (Sweden)

    Gennadiy Vladimirovich Klimenkov

    2011-12-01

    Full Text Available Analysis of regional agricultural sector status and rural areas of Perm in 1990-2011 years indicates a systemic crisis of agriculture in Perm region, which is largely determined by the fact that Perm region has no strategy or strategic plan and program for sustainable agricultural sector and rural areas of Perm region development, there is no scheme of territorial development and master plans of territorial development with the development of agro-industrial complex of Perm region. In these circumstances, there is a steady downward trend in production, weakening and bankruptcy of enterprises, social impoverishment of rural areas, appearance of many of irreversible processes (sale and neglect of agricultural land, demographic problems associated with low living standards, population migration, policy optimization in the areas of education and health, union of territories, policy of depopulation of territories etc.. This paper presents main recommendations for improving the situation in agriculture of Perm region.

  11. Theoretical and methodological approaches to the diagnosis of the region's state material reservation system status

    Directory of Open Access Journals (Sweden)

    Aleksandr Anatol'evich Kuklin

    2011-09-01

    Full Text Available This paper reviews the structural components of the state reserve theory with elements of decomposition and tools for studies in separate directions. The system of state material reserve, which includes the following components: economy - people - natural environment - is a necessary and sufficient reserve for their operation and development which is having the ability to respond to short-, medium- and long-term fluctuations in the economy and consider the risks of adverse factors appliance. It was determined that a necessary and sufficient reserve for the operation and development of the region is a major factor in ensuring its economic security. A method of diagnostics for the state material reserve system within the economic security of the region is presented and described. The approbation of the methodological apparatus for the assessment of the state material reserve by the example on the Ural Federal District was done.

  12. Energy dependency and sustainable regional development in the Baltic states: A review

    Directory of Open Access Journals (Sweden)

    Štreimikienė Dalia

    2016-01-01

    Full Text Available Energy security is one of the most important indicators of sustainable regional development and 'green' growth in implementation of EU strategy Europe 2020. It can provide the harmonized development and cohesion of 'old' and 'new' EU member states. Our paper conducts a comparative study of energy dependency and energy security indicators in the Baltic States. The Baltic countries achieved enormous progress in the use of renewable energy sources and energy efficiency since their EU accession in 2004. The increase of renewable energy capacities in Baltic States also contributed to the reduction of energy intensity and carbon intensity of economy and energy import dependency. Our results show that amongst all three states, it was Estonia that had achieved the best results in increased use of renewables and energy efficiency improvements and had distinguished itself with the best indicators and economic and regional policy outcomes.

  13. Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI.

    Directory of Open Access Journals (Sweden)

    Weidong Fang

    Full Text Available Essential tremor (ET is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI, as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC. The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.

  14. Regional brain activation associated with addiction of computer games in adolescents

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Y. H.; Shin, O. J.; Ko, Y. W.; Kim, H. J.; Yun, M. J.; Lee, J. D. [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    2001-07-01

    Excessive computer game (CG) playing may cause not only behavioral addiction, but also potential negative effects on developing brain. It is necessary to reveal how brain is affected by excessive use of CG playing and behavioral addiction of it. By using PET, we address the issue seeking to identifying patterns of regional brain activation associated with behavioral addiction and excessive use of CG playing by adolescents. 6 normal control and 8 adolescents who were met by the criteria of behavioral addiction on the survey as addiction groups with an addiction of CG playing were participated. Initial screening survey which is the adapted version of DSM-IV for pathologic gambling was done. PET were performed twice in each participants both during resting state and after 20 min playing of CG. Psychological test including Youth Self Report (YSR), memory and attention test and vocabulary item from KWAIS were performed. Scores of the vocabulary item from KWAIS and social competence from YSR were significantly lower in the addiction group. On PET, addiction group showed higher resting metabolism on inferior frontal, premotor, prefrontal and superior temporal area. Adolescents with addiction of CG revealed different patterns of regional brain activation comparing to control groups. These suggest behavioral addiction and excessive use of CG may result in functional alteration of developing brain in adolescents.

  15. Regional brain activation associated with addiction of computer games in adolescents

    International Nuclear Information System (INIS)

    Yoo, Y. H.; Shin, O. J.; Ko, Y. W.; Kim, H. J.; Yun, M. J.; Lee, J. D.

    2001-01-01

    Excessive computer game (CG) playing may cause not only behavioral addiction, but also potential negative effects on developing brain. It is necessary to reveal how brain is affected by excessive use of CG playing and behavioral addiction of it. By using PET, we address the issue seeking to identifying patterns of regional brain activation associated with behavioral addiction and excessive use of CG playing by adolescents. 6 normal control and 8 adolescents who were met by the criteria of behavioral addiction on the survey as addiction groups with an addiction of CG playing were participated. Initial screening survey which is the adapted version of DSM-IV for pathologic gambling was done. PET were performed twice in each participants both during resting state and after 20 min playing of CG. Psychological test including Youth Self Report (YSR), memory and attention test and vocabulary item from KWAIS were performed. Scores of the vocabulary item from KWAIS and social competence from YSR were significantly lower in the addiction group. On PET, addiction group showed higher resting metabolism on inferior frontal, premotor, prefrontal and superior temporal area. Adolescents with addiction of CG revealed different patterns of regional brain activation comparing to control groups. These suggest behavioral addiction and excessive use of CG may result in functional alteration of developing brain in adolescents

  16. Saturated properties prediction in critical region by a quartic equation of state

    Directory of Open Access Journals (Sweden)

    Yong Wang

    2011-08-01

    Full Text Available A diverse substance library containing extensive PVT data for 77 pure components was used to critically evaluate the performance of a quartic equation of state and other four famous cubic equations of state in critical region. The quartic EOS studied in this work was found to significantly superior to the others in both vapor pressure prediction and saturated volume prediction in vicinity of critical point.

  17. Asian Regional Institutions and the Possibilities for Socializing the Behavior of States

    OpenAIRE

    Acharya, Amitav

    2011-01-01

    Departing from the traditional yardsticks for measuring the performance and effectiveness of regional institutions, this paper proposes a new framework to investigate their effect in the socialization (i.e. internalization of group norms by newcomers) of new members. Called Type III internalization, it represents a middle ground between Type I (i.e. member states simply acting according to group expectations, even if they may not agree with them), and Type II (i.e. states transforming themsel...

  18. Offshore Wind Jobs and Economic Development Impacts in the United States: Four Regional Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Tegen, S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Keyser, D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Flores-Espino, F. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Miles, J. [James Madison Univ., Harrisonburg, VA (United States); Zammit, D. [James Madison Univ., Harrisonburg, VA (United States); Loomis, D. [Great Lakes Wind Network, Cleveland, OH (United States)

    2015-02-01

    This report uses the offshore wind Jobs and Economic Development Impacts (JEDI) model and provides four case studies of potential offshore deployment scenarios in different regions of the United States: the Southeast, the Great Lakes, the Gulf Coast, and the Mid-Atlantic. Researchers worked with developers and industry representatives in each region to create potential offshore wind deployment and supply chain growth scenarios, specific to their locations. These scenarios were used as inputs into the offshore JEDI model to estimate jobs and other gross economic impacts in each region.

  19. State regulation as a tool for improving the economic security of the regions

    Directory of Open Access Journals (Sweden)

    Yu. M. Sokolinskaya

    2017-01-01

    Full Text Available Providing economic security for the development of regions, increasing their competitiveness, risk-free and sustainable activities are the main tasks of the regional program of social and economic development, which occupies a special place in the system of instruments for public management of these processes. The program of social and economic development is a unique strategy of the region aimed at security and optimization of the spatial structure and relations between the center and the regions in order to ensure economic security and growth by maximizing the effective use of existing internal and external factors. The institutional influence of the state in order to improve the economic security of regions and enterprises occurs palliatively when the business of the region is supported in direct – subsidies, and more often indirectly – compliance with the laws and regulations of the Russian Federation and the region, on the principles of institutional and market synergies. Adaptation of enterprises in the region to the market is difficult, when specific socio-organizational, economic, technical and technological, scientific, information activities in their interrelations function in the field of Russian laws. The search for ways to improve the economic security of the Russian Federation, regions and enterprises takes place in the context of global integration through the improvement of the mechanism of state regulation. An important task of the current stage of economic security of the country and regions is the construction of a system of its institutional organization that would be able to balance the levers of government with the opportunities of private enterprises, provide a quality level of providing the business with protection from terrorism, predation, financial risks, legal competition etc.

  20. Community preferences for health states associated with intimate partner violence.

    Science.gov (United States)

    Wittenberg, Eve; Lichter, Erika L; Ganz, Michael L; McCloskey, Laura A

    2006-08-01

    One in 4 women is affected by intimate partner violence in her lifetime. This article reports on a cross-sectional survey to estimate community preferences for health states resulting from intimate partner violence. A secondary analysis was conducted of data from a convenience sample of 93 abused and 138 nonabused women (231 total) recruited for in-person interviews from hospital outpatient department waiting rooms in metropolitan Boston, Massachusetts. SF-12 data were converted to utilities to describe community-perspective preferences for health states associated with intimate partner violence. Linear regression analysis was used to explore the association between violence and utility while controlling for other health and demographic factors. Median utility for intimate partner violence was between 0.58 and 0.63 on a scale of 0 (equivalent to death) to 1.0 (equivalent to optimal health), with a range from 0.64 to 0.66 for less severe violence to 0.53 to 0.62 for more severe violence. The data do not reveal whether violence itself is responsible for lower utility or whether a constellation of factors contributes to disutility experienced by women victims of abuse. The utility of health states experienced by women exposed to intimate partner violence is substantially diminished compared with optimal health and even other health conditions. These values quantify the substantial negative health impact of the experience of intimate partner violence in terms that allow comparison across diseases. They can be used in cost-effectiveness analyses to identify the benefits and potential returns from resources allocated to violence prevention and intervention efforts.

  1. 75 FR 47302 - Notice of FERC Attendance at the Entergy Regional State Committee Meeting, Entergy ICT...

    Science.gov (United States)

    2010-08-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of FERC Attendance at the Entergy Regional State Committee Meeting, Entergy ICT Tranmission Planning Summit and Entergy SPP RTO Planning... Orleans, 500 Canal Street, New Orleans, LA 70130, 504-525-2500. Entergy ICT Transmission Planning Summit...

  2. Economic separatism in the European Union member states as a factor of regional security

    Directory of Open Access Journals (Sweden)

    A A Shakhina

    2014-12-01

    Full Text Available The article is devoted to the examination of the economic separatism problem in the European Union member states. It considers specific of the regional separatist movements as exemplified by the conflicts in Scotland, Catalonia, Bavaria, Flanders. Various points of view on the relevance of the budgetary separatism for the European integration process are given in the article.

  3. Access to Supplemental Educational Services in the Central Region States. Issues & Answers. REL 2007-No. 007

    Science.gov (United States)

    Barley, Zoe; Wegner, Sandra K.

    2007-01-01

    The Central Region states (Colorado, Kansas, Missouri, Nebraska, North Dakota, South Dakota, and Wyoming) lag behind the nation in the rate of participation in supplemental educational services that schools failing to make adequate progress for three consecutive years must offer to eligible students under the No Child Left Behind Act. This study…

  4. 77 FR 12770 - Approval, Disapproval and Promulgation of Implementation Plans; Nebraska; Regional Haze State...

    Science.gov (United States)

    2012-03-02

    ... growth of plant life and death of animal life from lack of oxygen. Data from the existing visibility... sky. B. Requirements of the CAA and EPA's Regional Haze Rule (RHR) In section 169A of the 1977...; and (4) the remaining useful life of any potentially affected sources. States must demonstrate in...

  5. 77 FR 11937 - Approval and Promulgation of Air Quality Implementation Plans; State of Alabama; Regional Haze...

    Science.gov (United States)

    2012-02-28

    ..., at which a dark object can be viewed against the sky. B. Requirements of the CAA and EPA's Regional... compliance; and (4) the remaining useful life of any potentially affected sources. States must demonstrate in... existing pollution control technology in use at the source, (4) the remaining useful life of the source...

  6. 75 FR 55274 - Change of Address for Region 5 State and Local Agencies; Technical Correction

    Science.gov (United States)

    2010-09-10

    ... Lafayette Road North, St. Paul, Minnesota 55155, rather than to EPA's Region 5 office. Subpart KK--Ohio 0 6..., Division of Air Quality, 520 Lafayette Road North, St. Paul, Minnesota 55155. * * * * * (KK) State of Ohio..., Logan, OH 43138. (xi) Champaign, Clinton, Highland, Logan, and Shelby Counties; Ohio Environmental...

  7. New nuclear weapon states and their impact on Third World regional conflicts

    International Nuclear Information System (INIS)

    Mazrui, A.A.

    1986-01-01

    The paper examines the new nuclear weapon states and their impact on third world regional conflicts. Nuclear technology in South Africa, nuclear terrorism and the Arab/Israeli conflict, Islam and the nuclear age, Egypt and the Non-Proliferation Treaty, and the 'masculinity' of warfare, are all discussed. (UK)

  8. Regional cerebral blood flow changes related to affective speech presentation in persistent vegetative state

    NARCIS (Netherlands)

    deJong, BM; Willemsen, ATM; Paans, AMJ

    A story told by his mother was presented on tape to a trauma patient in persistent vegetative state (PVS). During auditory presentation, measurements of regional cerebral blood flow (rCBF) were performed by means of positron emission tomography (PET). Changes in rCBF related to this stimulus

  9. 77 FR 31240 - Approval and Promulgation of Air Quality Implementation Plans; State of Florida; Regional Haze...

    Science.gov (United States)

    2012-05-25

    ... CAIR to address BART requirements related to both nitrogen oxides (NOx) and sulfur dioxide (SO 2..., memorandum from William L. Wehrum, Acting Assistant Administrator for Air and Radiation, to EPA Regional... generating plant with a total generating capacity in excess of 750 megawatts (MW), a state must use the...

  10. Timber harvesting patterns for major states in the central, northern, and mid-Atlantic hardwood regions

    Science.gov (United States)

    William G. Luppold; Matthew S. Bumgardner

    2018-01-01

    Timber harvesting is a major disturbance agent influencing the composition and structure of eastern hardwood forests. To better understand timber harvesting practices, we examined roundwood harvesting patterns in 13 eastern states in the Central, Mid-Atlantic, and Northern regions that contained high proportional volumes of hardwood in their forest inventories. Nearly...

  11. Extension of the new proposed association equation of state (AEOS) to associating fluid mixtures

    International Nuclear Information System (INIS)

    Rezaei, H.; Modarress, H.; Mohsen-Nia, M.

    2010-01-01

    Recently, a new statistical mechanic-based equation of state has been proposed by Mohsen-Nia and Modarress [M. Mohsen-Nia, H. Modarress, Chem. Phys. 336 (2007) 22-26] for associating pure fluids. The new association equation of state (AEOS) was successfully applied to calculate the saturated properties of water, methanol, and ammonia. In this work, the new proposed AEOS is used to evaluate the (vapour + liquid) equilibrium (VLE) of 25 associating pure compounds and the adjusted parameters are reported. The new AEOS is also extended to mixtures containing associating and non-associating compounds. The calculated saturated properties of the pure compounds are compared with those calculated by other AEOSs. The results of VLE calculation for various binary mixtures such as: alcohol/hydrocarbon, alcohol/CO 2 , alcohol/aromatic-hydrocarbons, and the quaternary system (H 2 O/CH 4 /CO 2 /H 2 S) indicate the capability of the new proposed AEOS for associating pure and mixture calculations.

  12. Analysis of environment state in technogenic region and its threat to public health

    Directory of Open Access Journals (Sweden)

    Grishenko S.V.

    2014-03-01

    Full Text Available The purpose of the research is to give a complex hygienic evaluation of environment state in Donetsk region and to determine the degree of their potential danger to population health. It includes air pollution, water contamination, state of soil. Nearly 43000 samples of air, 32000 drinking water samples and 4500 soil samples were analyzed. Regions with the highest rate of environmental pollution were defined. It was found that the main sources of environment pollution in Donetsk region are ferrous and nonferrous metallurgy enterprises, power, coal, building industry and transport. All other sources ac¬count for only 5-10% of total emissions. Level of harmful technogenic pressing on population’s health was determined.

  13. Plant-parasitic nematodes associated with olive trees in Al-Jouf region, north Saudi Arabia

    Science.gov (United States)

    A preliminary survey of plant-parasitic nematodes associated with olive was performed in Al-Jouf region, north Saudi Arabia. Olive is a newly introduced crop in this region, and is cultivated in the agricultural enterprises of some of the biggest Saudi agricultural companies. Seedlings are mostly im...

  14. Can National Healthcare-Associated Infections (HAIs) Data Differentiate Hospitals in the United States?

    Science.gov (United States)

    Masnick, Max; Morgan, Daniel J; Sorkin, John D; Macek, Mark D; Brown, Jessica P; Rheingans, Penny; Harris, Anthony D

    2017-10-01

    OBJECTIVE To determine whether patients using the Centers for Medicare and Medicaid Services (CMS) Hospital Compare website (http://medicare.gov/hospitalcompare) can use nationally reported healthcare-associated infection (HAI) data to differentiate hospitals. DESIGN Secondary analysis of publicly available HAI data for calendar year 2013. METHODS We assessed the availability of HAI data for geographically proximate hospitals (ie, hospitals within the same referral region) and then analyzed these data to determine whether they are useful to differentiate hospitals. We assessed data for the 6 HAIs reported by hospitals to the Centers for Disease Control and Prevention (CDC). RESULTS Data were analyzed for 4,561 hospitals representing 88% of registered community and federal government hospitals in the United States. Healthcare-associated infection data are only useful for comparing hospitals if they are available for multiple hospitals within a geographic region. We found that data availability differed by HAI. Clostridium difficile infections (CDI) data were most available, with 82% of geographic regions (ie, hospital referral regions) having >50% of hospitals reporting them. In contrast, 4% of geographic regions had >50% of member hospitals reporting surgical site infections (SSI) for hysterectomies, which had the lowest availability. The ability of HAI data to differentiate hospitals differed by HAI: 72% of hospital referral regions had at least 1 pair of hospitals with statistically different risk-adjusted CDI rates (SIRs), compared to 9% for SSI (hysterectomy). CONCLUSIONS HAI data generally are reported by enough hospitals to meet minimal criteria for useful comparisons in many geographic locations, though this varies by type of HAI. CDI and catheter-associated urinary tract infection (CAUTI) are more likely to differentiate hospitals than the other publicly reported HAIs. Infect Control Hosp Epidemiol 2017;38:1167-1171.

  15. RESISTÊNCIA ANTI-HELMÍNTICA EM REBANHOS OVINOS DA REGIÃO DA ASSOCIAÇÃO DOS MUNICÍPIOS DO ALTO IRANI (AMAI, OESTE DE SANTA CATARINA ANTHELMINTIC RESISTANCE ON SHEEP FLOCKS FROM ASSOCIATION OF THE MUNICIPALITIES OF THE ALTO IRANI REGION (AMAI, WEST OF SANTA CATARINA STATE, BRAZIL

    Directory of Open Access Journals (Sweden)

    Ingrid Kelly Zanchet

    2007-09-01

    Full Text Available

    Para conhecer a situação da resistência anti-hel-míntica em ovinos de propriedades localizadas nos mu-nicípios da Associação dos Municípios do Alto Irani (AMAI, oeste de Santa Catarina, Brasil, foram avalia-dos nove rebanhos pelo teste de redução da OPG (ovos por grama de fezes. Este teste consiste na comparação da média da OPG de um grupo de animais quatorze dias após o tratamento com a média de um grupo controle não-medicado. Consideraram-se efetivas as drogas capazes de reduzir a OPG em 95%. Os princípios ativos utilizados foram: levamisol (7,5 mg/kg, closantel (7,5 mg/Kg, al-bendazol (10 e 5 mg/Kg, ivermectin e moxidectin (0,2 mg/Kg. Detectou-se resistência dos nematódeos gastrin-testinais a todos os grupos anti-helmínticos testados, sen-do que 100% das propriedades apresentam resistência ao ivermectin; 66,7% ao moxidectin, 44,4% ao levamisol e 75% aos benzimidazóis. Para as lactonas macrocíclicas e benzimidazóis, tanto o gênero Haemonchus sp. quanto Trichostrongylus sp. apresentaram resistência. Para o le-vamisol, a resistência está restrita a Trichostrongylus sp. Também foi detectada a presença de uma população de Haemonchus sp. resistente ao closantel e uma de Nema-todirus sp. resistente ao albendazol. Estes dados mostram a urgência de difundir medidas de controle integrado de parasitoses, visando prolongar a vida  útil dos princípios ativos ainda disponíveis para uso.

    PALAVRAS-CHAVES: Ovinos, resistência anti-helmíntica, Santa Catarina.

    In order to know the situation of the anthelmintic resistance in sheep farms in the municipalities of Asso-ciation of the municipalities of the High Irani Region - AMAI, West of Santa Catarina State, Brazil, nine flocks were submitted to the faecal egg counts reduction test (FECRT. This test consists in comparing the mean FEC of a group of sheep, 14 days after treatment with the mean FEC of a non-treated control group. Only drugs that could

  16. Regional Variability and Uncertainty of Electric Vehicle Life Cycle CO₂ Emissions across the United States.

    Science.gov (United States)

    Tamayao, Mili-Ann M; Michalek, Jeremy J; Hendrickson, Chris; Azevedo, Inês M L

    2015-07-21

    We characterize regionally specific life cycle CO2 emissions per mile traveled for plug-in hybrid electric vehicles (PHEVs) and battery electric vehicles (BEVs) across the United States under alternative assumptions for regional electricity emission factors, regional boundaries, and charging schemes. We find that estimates based on marginal vs average grid emission factors differ by as much as 50% (using National Electricity Reliability Commission (NERC) regional boundaries). Use of state boundaries versus NERC region boundaries results in estimates that differ by as much as 120% for the same location (using average emission factors). We argue that consumption-based marginal emission factors are conceptually appropriate for evaluating the emissions implications of policies that increase electric vehicle sales or use in a region. We also examine generation-based marginal emission factors to assess robustness. Using these two estimates of NERC region marginal emission factors, we find the following: (1) delayed charging (i.e., starting at midnight) leads to higher emissions in most cases due largely to increased coal in the marginal generation mix at night; (2) the Chevrolet Volt has higher expected life cycle emissions than the Toyota Prius hybrid electric vehicle (the most efficient U.S. gasoline vehicle) across the U.S. in nearly all scenarios; (3) the Nissan Leaf BEV has lower life cycle emissions than the Prius in the western U.S. and in Texas, but the Prius has lower emissions in the northern Midwest regardless of assumed charging scheme and marginal emissions estimation method; (4) in other regions the lowest emitting vehicle depends on charge timing and emission factor estimation assumptions.

  17. Association of processed food, synergistic effect of alcohol and HBV with Hepatocellular Carcinoma in a high incidence region of India.

    Science.gov (United States)

    Phukan, Rup Kumar; Borkakoty, Biswa Jyoti; Phukan, Sanjib Kumar; Bhandari, Kumar; Mahanta, Jagdish; Tawsik, Sopai; Bhandari, Sangita; Rai, Ashish; Narain, Kanwar

    2018-04-01

    Dietary factors, tobacco, and alcohol use have been identified as important factors of rising various cancer incidence in several northeastern states of India. However, little is known about the factors associated with hepatocellular carcinoma (HCC) in this region. The aim of the paper was to identify the factors associated with HCC in the northeast region. A case-control study was conducted in Arunachal Pradesh and Sikkim, two northeastern states of India, including 104 histologically-confirmed cases of HCC and same number (104) of age and sex matched control enrolled. Logistic regression analysis was performed to identify the factors associated with HCC. A statistically significant association was demonstrated between HCC and alcohol consumption, consumption of 'Sai-mod' (OR 2.77, CI 1.57-4.87) a homemade alcohol beverage, and with HBV (OR 7.97, CI 3.36-18.94). Positive synergism index (S = 3.04) was observed between HBV and alcohol consumption to risk of HCC. Higher intake of processed meat (OR 2.56, CI 1.09-6.03) and processed fish (OR 2.24, CI 1.02-4.95) were found associated with increased risk of HCC; and decreased risk of HCC with fresh fish, fruits, and milk. Strong relationship between different dietary factors, alcohol beverage with HCC suggests that control on dietary and drinking habit will be an important strategy to combat HCC in this region. Risk factors identified in this study will help to plan more effectively targeted risk reduction strategies and programs in this region. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. The United States Regional Association of the International Association for Landscape Ecology

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    Abstracts are presented from a meeting on landscape ecology. Topics include: conservation, climatic change, forest management, aquatic, wetland, rural and urban landscapes, land use, and biodiversity.

  19. The United States Regional Association of the International Association for Landscape Ecology

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    Abstracts are presented from a meeting on landscape ecology. Topics include: conservation, climatic change, forest management, aquatic, wetland, rural and urban landscapes, land use, and biodiversity.

  20. The special role of item-context associations in the direct-access region of working memory.

    Science.gov (United States)

    Campoy, Guillermo

    2017-09-01

    The three-embedded-component model of working memory (WM) distinguishes three representational states corresponding to three WM regions: activated long-term memory, direct-access region (DAR), and focus of attention. Recent neuroimaging research has revealed that access to the DAR is associated with enhanced hippocampal activity. Because the hippocampus mediates the encoding and retrieval of item-context associations, it has been suggested that this hippocampal activation is a consequence of the fact that item-context associations are particularly strong and accessible in the DAR. This study provides behavioral evidence for this view using an item-recognition task to assess the effect of non-intentional encoding and maintenance of item-location associations across WM regions. Five pictures of human faces were sequentially presented in different screen locations followed by a recognition probe. Visual cues immediately preceding the probe indicated the location thereof. When probe stimuli appeared in the same location that they had been presented within the memory set, the presentation of the cue was expected to elicit the activation of the corresponding WM representation through the just-established item-location association, resulting in faster recognition. Results showed this same-location effect, but only for items that, according to their serial position within the memory set, were held in the DAR.

  1. Sensitivity of simulated maize crop yields to regional climate in the Southwestern United States

    Science.gov (United States)

    Kim, S.; Myoung, B.; Stack, D.; Kim, J.; Hatzopoulos, N.; Kafatos, M.

    2013-12-01

    The sensitivity of maize yield to the regional climate in the Southwestern United States (SW US) has been investigated by using a crop-yield simulation model (APSIM) in conjunction with meteorological forcings (daily minimum and maximum temperature, precipitation, and radiation) from the North American Regional Reanalysis (NARR) dataset. The primary focus of this study is to look at the effects of interannual variations of atmospheric components on the crop productivity in the SW US over the 21-year period (1991 to 2011). First of all, characteristics and performance of APSIM was examined by comparing simulated maize yields with observed yields from United States Department of Agriculture (USDA) and the leaf-area index (LAI) from MODIS satellite data. Comparisons of the simulated maize yield with the available observations show that the crop model can reasonably reproduce observed maize yields. Sensitivity tests were performed to assess the relative contribution of each climate driver to regional crop yield. Sensitivity experiments show that potential crop production responds nonlinearly to climate drivers and the yield sensitivity varied among geographical locations depending on their mean climates. Lastly, a detailed analysis of both the spatial and temporal variations of each climate driver in the regions where maize is actually grown in three states (CA, AZ, and NV) in the SW US was performed.

  2. Wind Powering America's Regional Stakeholder Meetings and Priority State Reports: FY11 Summary

    Energy Technology Data Exchange (ETDEWEB)

    2013-06-01

    Beginning in 2010, DOE conducted an assessment of Wind Powering America (WPA) activities to determine whether the methods the department had used to help grow the wind industry to provide 2% of the nation's electrical energy should be the same methods used to achieve 20% of the nation's energy from wind (as described in the report 20% Wind Energy by 2030: Increasing Wind Energy's Contribution to U.S. Electricity Supply). After the assessment, it was determined that the initiative's state-based activities should be phased out as part of a shift to regional-based approaches. To assist with this transition, WPA hosted a series of 1-day regional meetings at six strategic locations around the country and a single teleconference for island states, U.S. territories, and remote communities. This report summarizes the results of the inaugural regional meetings and the state reports with a focus on ongoing wind deployment barriers in each region.

  3. Wind Powering America's Regional Stakeholder Meetings and Priority State Reports: FY11 Summary

    Energy Technology Data Exchange (ETDEWEB)

    Baring-Gould, Ian [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-06-01

    Beginning in 2010, DOE conducted an assessment of Wind Powering America (WPA) activities to determine whether the methods the department had used to help grow the wind industry to provide 2% of the nation's electrical energy should be the same methods used to achieve 20% of the nation's energy from wind (as described in the report 20% Wind Energy by 2030: Increasing Wind Energy's Contribution toU.S. Electricity Supply). After the assessment, it was determined that the initiative's state-based activities should be phased out as part of a shift to regional-based approaches. To assist with this transition, WPA hosted a series of 1-day regional meetings at six strategic locations around the country and a single teleconference for island states, U.S. territories, and remote communities.This report summarizes the results of the inaugural regional meetings and the state reports with a focus on ongoing wind deployment barriers in each region.

  4. Geology of the Curimatau medium region (Paraiba State, Brazil) and the emplacement of the Dona Ines granite associated to the Brasiliano transcurrent shear zones; Geologia da Regiao do Medio Curimatau (PB) e o alojamento do granito de Dona Ines associado a zonas de cisalhamento transcorrentes brasilianas

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Sergio Vieira Freire

    1996-12-31

    In an area of about 700 Km{sup 2} located in the northeast of Paraiba State and having as main point the town of Dona Ines, a geologic/structural mapping, a gravimetric survey and radiometric dating using the Rb/Sr method in whole rock and Sm.Nd model ages were undertaken in order to study and to understand the geology of this portion of terrain, the emplacement of the Dona Ines granitoids and its relationship with the enclosing rocks and the deformation acting at the time of the intrusion. The age of the pluton of Dona Ines was determined by the Rb/Sr whole rock method as 560 {+-} 20 Ma (end of Brasiliano Cycle in the region). Sm.Nd model ages in granitoids of Araras, Belem and Dona Ines have revealed paleoproterozoic ages for their crustal sources, as indicated by the negative {epsilon}{sub nd} of this rock 128 refs., 95 figs., 6 tabs., 7 maps

  5. Geology of the Curimatau medium region (Paraiba State, Brazil) and the emplacement of the Dona Ines granite associated to the Brasiliano transcurrent shear zones; Geologia da Regiao do Medio Curimatau (PB) e o alojamento do granito de Dona Ines associado a zonas de cisalhamento transcorrentes brasilianas

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Sergio Vieira Freire

    1997-12-31

    In an area of about 700 Km{sup 2} located in the northeast of Paraiba State and having as main point the town of Dona Ines, a geologic/structural mapping, a gravimetric survey and radiometric dating using the Rb/Sr method in whole rock and Sm.Nd model ages were undertaken in order to study and to understand the geology of this portion of terrain, the emplacement of the Dona Ines granitoids and its relationship with the enclosing rocks and the deformation acting at the time of the intrusion. The age of the pluton of Dona Ines was determined by the Rb/Sr whole rock method as 560 {+-} 20 Ma (end of Brasiliano Cycle in the region). Sm.Nd model ages in granitoids of Araras, Belem and Dona Ines have revealed paleoproterozoic ages for their crustal sources, as indicated by the negative {epsilon}{sub nd} of this rock 128 refs., 95 figs., 6 tabs., 7 maps

  6. Regional homogeneity changes in prelingually deafened patients: a resting-state fMRI study

    Science.gov (United States)

    Li, Wenjing; He, Huiguang; Xian, Junfang; Lv, Bin; Li, Meng; Li, Yong; Liu, Zhaohui; Wang, Zhenchang

    2010-03-01

    Resting-state functional magnetic resonance imaging (fMRI) is a technique that measures the intrinsic function of brain and has some advantages over task-induced fMRI. Regional homogeneity (ReHo) assesses the similarity of the time series of a given voxel with its nearest neighbors on a voxel-by-voxel basis, which reflects the temporal homogeneity of the regional BOLD signal. In the present study, we used the resting state fMRI data to investigate the ReHo changes of the whole brain in the prelingually deafened patients relative to normal controls. 18 deaf patients and 22 healthy subjects were scanned. Kendall's coefficient of concordance (KCC) was calculated to measure the degree of regional coherence of fMRI time courses. We found that regional coherence significantly decreased in the left frontal lobe, bilateral temporal lobes and right thalamus, and increased in the postcentral gyrus, cingulate gyrus, left temporal lobe, left thalamus and cerebellum in deaf patients compared with controls. These results show that the prelingually deafened patients have higher degree of regional coherence in the paleocortex, and lower degree in neocortex. Since neocortex plays an important role in the development of auditory, these evidences may suggest that the deaf persons reorganize the paleocortex to offset the loss of auditory.

  7. Red states, blue states, and divorce: understanding the impact of conservative Protestantism on regional variation in divorce rates.

    Science.gov (United States)

    Glass, Jennifer; Levchak, Philip

    2014-01-01

    Why do states with larger proportions of religious conservatives have higher divorce rates than states with lower proportions of religious conservatives? This project examines whether earlier transitions to marriage and parenthood among conservative Protestants (known risk factors for divorce) contribute to this paradox while attending to other plausible explanations. County-level demographic information from all 50 states is combined from a variety of public data sources and merged with individual records from the National Surveys of Family Growth to estimate both aggregated county and multilevel individual models of divorce. Results show that individual religious conservatism is positively related to individual divorce risk, solely through the earlier transitions to adulthood and lower incomes of conservative Protestants. However, the proportion of conservative Protestants in a county is also independently and positively associated with both the divorce rate in that county and an individual's likelihood of divorcing. The earlier family formation and lower levels of educational attainment and income in counties with a higher proportion of conservative Protestants can explain a substantial portion of this association. Little support is found for alternative explanations of the association between religious conservatism and divorce rates, including the relative popularity of marriage versus cohabitation across counties.

  8. Identification of genomic regions associated with resistance to clinical mastitis in US Holstein cattle

    Science.gov (United States)

    The objective of this research was to identify genomic regions associated with clinical mastitis (MAST) in US Holsteins using producer-reported data. Genome-wide association studies (GWAS) were performed on deregressed PTA using GEMMA v. 0.94. Genotypes included 60,671 SNP for all predictor bulls (n...

  9. Pediatric injuries associated with fireplaces, United States, 2002-2007.

    Science.gov (United States)

    Hammig, Bart J; Henry, Jean

    2011-02-01

    To examine injuries among pediatric patients treated in an emergency department (ED) related to contact with a fireplace. Data were obtained from the National Electronic Injury Surveillance System for the years 2002 through 2007. National estimates of ED visits for injuries associated with fireplaces were analyzed. Average annual rates were calculated, and logistic regression analyses were used to determine risk estimates for patient demographic characteristics related to ED visits for injuries associated with fireplaces. From 2002 through 2007, there were an estimated 8000 ED visits annually for injuries related to fireplaces in the United States, with an average annual rate of 18.8 ED visits per 100,000 children aged birth through 10 years. The most common injuries involved lacerations (66%), burns (10%), and contusions (10%). Most injuries occurred to the face (46%) or head (31%). Most patients (98%) were treated and released the same day. Results of logistic regression analyses revealed that children aged birth to 3 years (odds ratio, 12.2; 95% confidence interval, 9.1-16.5) and children aged 4 to 6 years (odds ratio, 4.8; 95% confidence interval, 3.5-6.5) were more likely present in an ED for a fireplace-related injury when compared with older children aged 7 to 10 years. Further research is warranted in the areas of etiology, injury prevention interventions, health communications, and surveillance to facilitate more effective injury prevention efforts.

  10. Regional growth management policies: Toward reducing global warming at state and local levels

    International Nuclear Information System (INIS)

    Purdie, J.

    1995-01-01

    State and local governments in the United States are accepting mandates to coordinate legislated land use and growth management planning with vigorous environmental protection and resource conservation. These mandates, implemented or planned in states with populations totaling over 100 million, will directly impact growth patterns and ultimately affect the level of atmospheric gases and particulates generated within their borders. This paper addresses the issues of growth management and land use planning at the local, state and regional levels and identifies areas impacting global warming. A review of existing systems will be presented, and recommendations will be made to improve monitoring of growth management mechanisms and organizational structures with the goal of global atmospheric improvement. The issues discussed include urban sprawl, transportation, and growth patterns as managed by policies also designed to protect environments and provide for sustainable growth. Areas for improved coordination between jurisdictions to ease global warming will also be examined

  11. Steady state models for filamentary plasma structures associated with force free magnetic fields

    International Nuclear Information System (INIS)

    Marklund, G.

    1978-05-01

    This paper presents a model for filamentary plasma structures associated with force-free magnetic fields. A homogenous electric field parallel to the symmetry axis of the magnetic field is assumed. Under the influence of these fields, the plasma will drift radially inwards resulting in an accumulation of plasma in the central region. We assume recombination losses to keep the central plasma density at a finite value, and the recombined plasma i.e. the neutrals to diffuse radially outwards. Plasma density and some neutral gas density distributions for a steady state situation are calculated for various cases

  12. Association of the 3′ Region of COMT with Schizophrenia in Taiwan

    Directory of Open Access Journals (Sweden)

    Yi-Ling Chien

    2009-04-01

    Conclusion: The SNP rs165599, which has been mapped to the 3′-UTR region of the COMT gene, was significantly associated with schizophrenia in our family study, and possibly associated with the age of onset, delusion/hallucination symptom dimension, and CPT performance. Therefore, COMT may contribute to the genetic risk for schizophrenia not through the Val108/158 Met polymorphism, but through other variants that are situated 3′ to this region, in the Taiwanese population. Nevertheless, the true associated functional variants in our subjects remain to be elucidated.

  13. Determinants of childhood diarrhea among underfive children in Benishangul Gumuz Regional State, North West Ethiopia

    Science.gov (United States)

    2014-01-01

    Background Diarrhea is second only to pneumonia as the cause of child mortality worldwide. Developing countries particularly in Sub Saharan Africa including Ethiopia have a high burden of this disease. Studies showed that different factors were associated with the occurrence of childhood diarrhea. Therefore, this study was aimed to identify determinant factors of diarrhea in underfive children in Benishangul Gumuz Regional State, western Ethiopia. Method Demographic and Health Survey (DHS) data of 2011 was used for this study. The data was extracted from the National DHS data using data extraction tools. A total of 925 under five children were selected. The logistic regression model was employed to examine the determinants of childhood diarrhoea. Both bivariate and multivariate data analysis was performed using SPSS version 16.0. Result The results of this study indicated that low level of maternal education [AOR = 1.81, 95% CI (1.12,2.76)], absence of toilet facility [AOR = 3.5, 95% CI (2.4, 5.2)], improper child stool disposal methods [AOR = 2.05, 95%CI (1.36, 3.10)], having more than two under five children [AOR = 1.73, 95% CI (1.03, 2.93)], higher birth order [AOR = 6.1, 95% CI (3.1,12.2)] and the age of children [AOR = 1.9, 95% CI (1.2, 3.6)] were found to be the risk factors for childhood diarrhea after adjusting for other variables. When toilet facility was stratified by maternal education, it showed that children of mothers who had no education were the most vulnerable in the absence of toilet facilities [OR = 9.16, 95% CI (5.79, 14.48)]. Conclusion Under poor environmental conditions, mothers with primary education and above protected their children against diarrhea better than mothers with no education. Thus, implementing effective educational programs that emphasize environmental health and sanitation practices and encouraging female school enrolment would reduce childhood diarrheal morbidity in the region. PMID:24731601

  14. Moral values are associated with individual differences in regional brain volume.

    Science.gov (United States)

    Lewis, Gary J; Kanai, Ryota; Bates, Timothy C; Rees, Geraint

    2012-08-01

    Moral sentiment has been hypothesized to reflect evolved adaptations to social living. If so, individual differences in moral values may relate to regional variation in brain structure. We tested this hypothesis in a sample of 70 young, healthy adults examining whether differences on two major dimensions of moral values were significantly associated with regional gray matter volume. The two clusters of moral values assessed were "individualizing" (values of harm/care and fairness) and "binding" (deference to authority, in-group loyalty, and purity/sanctity). Individualizing was positively associated with left dorsomedial pFC volume and negatively associated with bilateral precuneus volume. For binding, a significant positive association was found for bilateral subcallosal gyrus and a trend to significance for the left anterior insula volume. These findings demonstrate that variation in moral sentiment reflects individual differences in brain structure and suggest a biological basis for moral sentiment, distributed across multiple brain regions.

  15. Associations between indoor tanning and risky health-related behaviors among high school students in the United States

    OpenAIRE

    Chapman, Stephanie; Ashack, Kurt; Bell, Eric; Sendelweck, Myra Ann; Dellavalle, Robert

    2016-01-01

    Understanding of the associations between indoor tanning and risky health related behaviors such as sexual activity and substance abuse among adolescents across the United States is incomplete. The purpose of this study is to identify risky health related behaviors among high school students utilizing indoor tanning according to region. We analyzed the results from surveys of adolescents in 14 different states administered as part of the Youth Risk Behavior Surveillance System (YRBSS) 2013. D...

  16. Towards a regional coastal ocean observing system: An initial design for the Southeast Coastal Ocean Observing Regional Association

    Science.gov (United States)

    Seim, H. E.; Fletcher, M.; Mooers, C. N. K.; Nelson, J. R.; Weisberg, R. H.

    2009-05-01

    A conceptual design for a southeast United States regional coastal ocean observing system (RCOOS) is built upon a partnership between institutions of the region and among elements of the academic, government and private sectors. This design envisions support of a broad range of applications (e.g., marine operations, natural hazards, and ecosystem-based management) through the routine operation of predictive models that utilize the system observations to ensure their validity. A distributed information management system enables information flow, and a centralized information hub serves to aggregate information regionally and distribute it as needed. A variety of observing assets are needed to satisfy model requirements. An initial distribution of assets is proposed that recognizes the physical structure and forcing in the southeast U.S. coastal ocean. In-situ data collection includes moorings, profilers and gliders to provide 3D, time-dependent sampling, HF radar and surface drifters for synoptic sampling of surface currents, and satellite remote sensing of surface ocean properties. Nested model systems are required to properly represent ocean conditions from the outer edge of the EEZ to the watersheds. An effective RCOOS will depend upon a vital "National Backbone" (federally supported) system of in situ and satellite observations, model products, and data management. This dependence highlights the needs for a clear definition of the National Backbone components and a Concept of Operations (CONOPS) that defines the roles, functions and interactions of regional and federal components of the integrated system. A preliminary CONOPS is offered for the Southeast (SE) RCOOS. Thorough system testing is advocated using a combination of application-specific and process-oriented experiments. Estimates of costs and personnel required as initial components of the SE RCOOS are included. Initial thoughts on the Research and Development program required to support the RCOOS are

  17. Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women.

    Science.gov (United States)

    Georgiadis, Janniko R; Kortekaas, Rudie; Kuipers, Rutger; Nieuwenburg, Arie; Pruim, Jan; Reinders, A A T Simone; Holstege, Gert

    2006-12-01

    There is a severe lack of knowledge regarding the brain regions involved in human sexual performance in general, and female orgasm in particular. We used [15O]-H2O positron emission tomography to measure regional cerebral blood flow (rCBF) in 12 healthy women during a nonsexual resting state, clitorally induced orgasm, sexual clitoral stimulation (sexual arousal control) and imitation of orgasm (motor output control). Extracerebral markers of sexual performance and orgasm were rectal pressure variability (RPstd) and perceived level of sexual arousal (PSA). Sexual stimulation of the clitoris (compared to rest) significantly increased rCBF in the left secondary and right dorsal primary somatosensory cortex, providing the first account of neocortical processing of sexual clitoral information. In contrast, orgasm was mainly associated with profound rCBF decreases in the neocortex when compared with the control conditions (clitoral stimulation and imitation of orgasm), particularly in the left lateral orbitofrontal cortex, inferior temporal gyrus and anterior temporal pole. Significant positive correlations were found between RPstd and rCBF in the left deep cerebellar nuclei, and between PSA and rCBF in the ventral midbrain and right caudate nucleus. We propose that decreased blood flow in the left lateral orbitofrontal cortex signifies behavioural disinhibition during orgasm in women, and that deactivation of the temporal lobe is directly related to high sexual arousal. In addition, the deep cerebellar nuclei may be involved in orgasm-specific muscle contractions while the involvement of the ventral midbrain and right caudate nucleus suggests a role for dopamine in female sexual arousal and orgasm.

  18. 1P autoionization states of He in the elastic scattering region

    International Nuclear Information System (INIS)

    Chen, I.H.

    1975-01-01

    Following the method of Feshbach projection operator formalism, 1 P autoionization states of He in the n = 1 to n = 2 energy region was investigated. Variational functionals are constructed for solving the closed channel components and these results are compared with the absorption spectrum measured by Madden and Codling. In the open channel components the Coulomb wave function is used. Together with closed channel components, we calculate the line width of 1 P and 3 P resonance states. Comparison of these results with the previous calculation and with experimental data is also discussed

  19. THE ROLE OF UNASUR IN INTRA-STATE CONFLICTS IN THE REGION

    Directory of Open Access Journals (Sweden)

    ALEJANDRO AMIGO TOSSI

    2017-12-01

    Full Text Available The UNASUR treaty does not consider the prevention of conflicts, however, one of its objectives is to create an area of peace in South America, and for that purpose, has intervened in a series of conflicts that have threatened the stability of the region. The cases have gone from the stabilization of an inter-state crisis to an unsuccessful attempt to stop a president’s impeachment. This article describes the circumstances that shaped the internal conflicts of Bolivia in 2008, Ecuador in 2010 and Paraguay in 2012; and the subsequent role of UNASUR in those intra-state situations.

  20. The Current State and Historico-geographical Background of Mt. Chirisan Region Immigrants

    Directory of Open Access Journals (Sweden)

    Sungho Kang

    2016-08-01

    Full Text Available This paper examined the historico-geographical background and current state of immigrants in the area designated as the “Mt. Chirisan Region,” their characteristics, and related integration issues. This article defines the Mt. Chirisan Region as the 7 cities/kuns of Namwŏn-si, Changsu-kun, Koksŏng-kun, Kurye-kun, Hadong-kun, Sanchŏng-kun, and Hamyang-kun. As the Mt. Chirisan Region mainly consists of mountainous and agricultural areas, the immigrant induction effect socio-economically was low relative to urban and industrial areas. It was also noted that, as the percentage of marriage immigration in Mt. Chirisan was high relative to urban or industrial areas, the female foreigner ratio was higher than that of male foreigners. In regard to the home countries of immigrants, women from South-East Asia and North-East Asia accounted for the majority. Also, this article examines the current situation of support programs of 7 local Multicultural Family Support Centers in the Mt. Chirisan Region, their problems, and probably solutions. Based on the historical development of the region and recent social changes, our society and government need to actively develop a higher level of social integration and employment education support programs, and carry out policies that will protect the diverse cultural identities of immigrants. In addition, differentiated multicultural family support programs appropriate for Mt. Chirisan, an inland mountain region, need to be developed.

  1. Alterations in regional homogeneity of resting-state brain activity in internet gaming addicts

    Directory of Open Access Journals (Sweden)

    Dong Guangheng

    2012-08-01

    Full Text Available Abstract Backgrounds Internet gaming addiction (IGA, as a subtype of internet addiction disorder, is rapidly becoming a prevalent mental health concern around the world. The neurobiological underpinnings of IGA should be studied to unravel the potential heterogeneity of IGA. This study investigated the brain functions in IGA patients with resting-state fMRI. Methods Fifteen IGA subjects and fourteen healthy controls participated in this study. Regional homogeneity (ReHo measures were used to detect the abnormal functional integrations. Results Comparing to the healthy controls, IGA subjects show enhanced ReHo in brainstem, inferior parietal lobule, left posterior cerebellum, and left middle frontal gyrus. All of these regions are thought related with sensory-motor coordination. In addition, IGA subjects show decreased ReHo in temporal, occipital and parietal brain regions. These regions are thought responsible for visual and auditory functions. Conclusions Our results suggest that long-time online game playing enhanced the brain synchronization in sensory-motor coordination related brain regions and decreased the excitability in visual and auditory related brain regions.

  2. Neuropsychological state of the population living in the Aral Sea region (zone of ecological crisis).

    Science.gov (United States)

    Sakiev, Kanat; Battakova, Sharbanu; Namazbaeva, Zulkiya; Ibrayeva, Lyazat; Otarbayeva, Maral; Sabirov, Zhanbol

    2017-04-01

    Background The Aral Sea crisis has led to harmful effects on human habitat. In recent years, mild cognitive impairment is a growing problem. Objectives This article provides the results of studying the neuropsychological state of residents living in the crisis zone of the Aral Sea region in the case of Shalkar city. We have provided an assessment of the neuropsychological state of examined population and determined the leading pathology in this region. Methods The survey sample included 344 persons of reproductive age from 21 to 45 years. We have obtained results in biochemical studies, indicating perturbations of proteometabolism and lipid metabolism. Results A correlation analysis showed dependence between a decrease of albumin and high-density lipoproteins, an increase of low-density lipoproteins and parameters of cognitive function. Conclusions The research suggests a high prevalence of cerebrovascular pathology among the population, changes in cognitive function parameters, long-term and short-term memory problems and high levels of depression.

  3. Prevalence and determinants of common mental illness among adult residents of Harari Regional State, Eastern Ethiopia

    Science.gov (United States)

    Hunduma, Gari; Girma, Mulugeta; Digaffe, Tesfaye; Weldegebreal, Fitsum; Tola, Assefa

    2017-01-01

    Introduction Common mental disorders include depression, anxiety and somatoform disorders are a public health problem in developed as well as developing countries. It represents a psychiatric morbidity with significant prevalence, affecting all stages of life and cause suffering to the individuals, their family and communities. Despite this fact, little information about the prevalence of common mental illness is available from low and middle-income countries including Ethiopia. The aim of this study was to determine the magnitude of common mental disorders and its associated factors among adult residents of Harari Region. Methods Comparative cross-sectional, quantitative community-based survey was conducted From February 1, 2016 to March 30, 2016 in Harari Regional State using multi-stage sampling technique. A total of 968 residents was selected using two stage sampling technique. Of this 901 were participated in the study. Validated and Pretested Self reported questionnaire (SQR_20) was used to determine the maginitude of common mental disorders. Data was entered and analyzed using Epi-info version 3.5.1 and SPSS-17 for windows statistical packages. Univirate, Bi-variate and multivariate logistic regression analysis with 95% CI was employed in order to infer associations. Results The prevalence of common mental illnesses among adults in our study area was 14.9%. The most common neurotic symptoms in this study were often head ache (23.2%), sleep badly (16%) and poor appetite (13.8%). Substance use like Khat chewing (48.2%), tobacco use (38.2%) and alcohol use (10.5%) was highly prevalent health problem among study participant. In multivariate logistic regression analysis, respondents age between 25-34 years, 35-44 years, 45-54 years and above 55years were 6.4 times (AOR 6.377; 95% CI: 2.280-17.835), 5.9 times (AOR 5.900; 95% CI: 2.243-14.859), 5.6 times (AOR 5.648; 95% CI: 2.200-14.50) and 4.1 times (AOR 4.110; 95% CI: 1.363-12.393) more likely having common

  4. Brain regions associated with Anhedonia in healthy adults: a PET correlation study

    International Nuclear Information System (INIS)

    Jung, Young Chul; Chun, Ji Won; Kim, Jae Jin; Park, Hae Jeong; Lee, Jong Doo; Seok, Jeong Ho

    2005-01-01

    Anhedonia has been proposed to be the result of a basic neurophysiologic dysfunction and a vulnerability marker that precede and contribute to the liability of developing schizophrenia. We hypothesized that anhedonia, as a construct reflecting the decreased capacity to experience pleasure, should be associated with decreased positive hedonic affect trait. This study examined the relationship between anhedonia and positive hedonic affect trait and searched for the brain regions which correlate with anhedonia in normal subjects. Using 18 F-FDG PET scan, we investigated the brain activity of twenty one subjects during resting state. Questionnaires were administrated after the scan in order to assess the self-rated individual differences in physical/social anhedonia and positive/negative affect traits. Negative correlation between physical anhedonia score and positive affect trait score was significant (Pearson coefficient=-0.440, ρ <0.05). The subjects' physical and social anhedonia scores showed positive correlation with metabolic rates in the cerebellum and negative correlation with metabolic rates in the inferior temporal gyrus and middle frontal gyrus. In addition, the positive affect trait score positively correlated with various areas, most prominent with the inferior temporal gyrus. These results suggest that neural substrates, such as the inferior temporal gyrus and prefrontal-cerebellar circuit, which dysfunction has been proposed to be involved with the cognitive deficits of schizophrenia, may also play a significant role in the liability of affective deficits like anhedonia

  5. Brain regions associated with Anhedonia in healthy adults: a PET correlation study

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Young Chul; Chun, Ji Won; Kim, Jae Jin; Park, Hae Jeong; Lee, Jong Doo [Yonsei University College of Medicine, Gwangju (Korea, Republic of); Seok, Jeong Ho [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2005-10-15

    Anhedonia has been proposed to be the result of a basic neurophysiologic dysfunction and a vulnerability marker that precede and contribute to the liability of developing schizophrenia. We hypothesized that anhedonia, as a construct reflecting the decreased capacity to experience pleasure, should be associated with decreased positive hedonic affect trait. This study examined the relationship between anhedonia and positive hedonic affect trait and searched for the brain regions which correlate with anhedonia in normal subjects. Using {sup 18}F-FDG PET scan, we investigated the brain activity of twenty one subjects during resting state. Questionnaires were administrated after the scan in order to assess the self-rated individual differences in physical/social anhedonia and positive/negative affect traits. Negative correlation between physical anhedonia score and positive affect trait score was significant (Pearson coefficient=-0.440, {rho} <0.05). The subjects' physical and social anhedonia scores showed positive correlation with metabolic rates in the cerebellum and negative correlation with metabolic rates in the inferior temporal gyrus and middle frontal gyrus. In addition, the positive affect trait score positively correlated with various areas, most prominent with the inferior temporal gyrus. These results suggest that neural substrates, such as the inferior temporal gyrus and prefrontal-cerebellar circuit, which dysfunction has been proposed to be involved with the cognitive deficits of schizophrenia, may also play a significant role in the liability of affective deficits like anhedonia.

  6. Functional connectivity associated with social networks in older adults: A resting-state fMRI study.

    Science.gov (United States)

    Pillemer, Sarah; Holtzer, Roee; Blumen, Helena M

    2017-06-01

    Poor social networks and decreased levels of social support are associated with worse mood, health, and cognition in younger and older adults. Yet, we know very little about the brain substrates associated with social networks and social support, particularly in older adults. This study examined functional brain substrates associated with social networks using the Social Network Index (SNI) and resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data from 28 non-demented older adults were analyzed with independent components analyses. As expected, four established resting-state networks-previously linked to motor, vision, speech, and other language functions-correlated with the quality (SNI-1: total number of high-contact roles of a respondent) and quantity (SNI-2: total number of individuals in a respondent's social network) of social networks: a sensorimotor, a visual, a vestibular/insular, and a left frontoparietal network. Moreover, SNI-1 was associated with greater functional connectivity in the lateral prefrontal regions of the left frontoparietal network, while SNI-2 was associated with greater functional connectivity in the medial prefrontal regions of this network. Thus, lateral prefrontal regions may be particularly linked to the quality of social networks while medial prefrontal regions may be particularly linked to the quantity of social networks.

  7. A genome-wide association scan in pig identifies novel regions associated with feed efficiency trait

    DEFF Research Database (Denmark)

    Sahana, Goutam; Kadlecová, Veronika; Hornshøj, Henrik

    2013-01-01

    Feed conversion ratio (FCR) is an economically important trait in pigs and feed accounts for a significant proportion of the costs involved in pig production. In this study we used a high density SNP chip panel, Porcine SNP60 BeadChip, to identify association between FCR and SNP markers and to st...

  8. Projecting changes in regional temperature and precipitation extremes in the United States

    OpenAIRE

    Justin T. Schoof; Scott M. Robeson

    2016-01-01

    Regional and local climate extremes, and their impacts, result from the multifaceted interplay between large-scale climate forcing, local environmental factors (physiography), and societal vulnerability. In this paper, we review historical and projected changes in temperature and precipitation extremes in the United States, with a focus on strengths and weaknesses of (1) commonly used definitions for extremes such as thresholds and percentiles, (2) statistical approaches to quantifying change...

  9. Scaled parametric equation of state for steam in the critical region

    International Nuclear Information System (INIS)

    Murphy, T.A.; Sengers, J.V.

    1975-01-01

    The anomalous thermodynamic behavior of fluids near the critical point can be described in terms of scaling laws. In recent years a parametric equation of state, the so-called Linear Model, has been proposed that satisfies the scaling laws and contains only a small number of adjustable parameters. It is shown that the Linear Model yields a satisfactory representation of the experimental P-V-T data for steam in the critical region. (29 references)

  10. Characterization of seven United States coal regions. The development of optimal terrace pit coal mining systems

    Energy Technology Data Exchange (ETDEWEB)

    Wimer, R.L.; Adams, M.A.; Jurich, D.M.

    1981-02-01

    This report characterizes seven United State coal regions in the Northern Great Plains, Rocky Mountain, Interior, and Gulf Coast coal provinces. Descriptions include those of the Fort Union, Powder River, Green River, Four Corners, Lower Missouri, Illinois Basin, and Texas Gulf coal resource regions. The resource characterizations describe geologic, geographic, hydrologic, environmental and climatological conditions of each region, coal ranks and qualities, extent of reserves, reclamation requirements, and current mining activities. The report was compiled as a basis for the development of hypothetical coal mining situations for comparison of conventional and terrace pit surface mining methods, under contract to the Department of Energy, Contract No. DE-AC01-79ET10023, entitled The Development of Optimal Terrace Pit Coal Mining Systems.

  11. Regional study on investment for transmission infrastructure in China based on the State Grid data

    Science.gov (United States)

    Wei, Wendong; Wu, Xudong; Wu, Xiaofang; Xi, Qiangmin; Ji, Xi; Li, Guoping

    2017-03-01

    Transmission infrastructure is an integral component of safeguarding the stability of electricity delivery. However, existing studies of transmission infrastructure mostly rely on a simple review of the network, while the analysis of investments remains rudimentary. This study conducted the first regionally focused analysis of investments in transmission infrastructure in China to help optimize its structure and reduce investment costs. Using State Grid data, the investment costs, under various voltages, for transmission lines and transformer substations are calculated. By analyzing the regional profile of cumulative investment in transmission infrastructure, we assess correlations between investment, population, and economic development across the regions. The recent development of ultra-high-voltage transmission networks will provide policy-makers new options for policy development.

  12. Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus.

    Directory of Open Access Journals (Sweden)

    Stephen N White

    Full Text Available BACKGROUND: Like human immunodeficiency virus (HIV, ovine lentivirus (OvLV is macrophage-tropic and causes lifelong infection. OvLV infects one quarter of U.S. sheep and induces pneumonia and body condition wasting. There is no vaccine to prevent OvLV infection and no cost-effective treatment for infected animals. However, breed differences in prevalence and proviral concentration have indicated a genetic basis for susceptibility to OvLV. A recent study identified TMEM154 variants in OvLV susceptibility. The objective here was to identify additional loci associated with odds and/or control of OvLV infection. METHODOLOGY/PRINCIPAL FINDINGS: This genome-wide association study (GWAS included 964 sheep from Rambouillet, Polypay, and Columbia breeds with serological status and proviral concentration phenotypes. Analytic models accounted for breed and age, as well as genotype. This approach identified TMEM154 (nominal P=9.2×10(-7; empirical P=0.13, provided 12 additional genomic regions associated with odds of infection, and provided 13 regions associated with control of infection (all nominal P<1 × 10(-5. Rapid decline of linkage disequilibrium with distance suggested many regions included few genes each. Genes in regions associated with odds of infection included DPPA2/DPPA4 (empirical P=0.006, and SYTL3 (P=0.051. Genes in regions associated with control of infection included a zinc finger cluster (ZNF192, ZSCAN16, ZNF389, and ZNF165; P=0.001, C19orf42/TMEM38A (P=0.047, and DLGAP1 (P=0.092. CONCLUSIONS/SIGNIFICANCE: These associations provide targets for mutation discovery in sheep susceptibility to OvLV. Aside from TMEM154, these genes have not been associated previously with lentiviral infection in any species, to our knowledge. Further, data from other species suggest functional hypotheses for future testing of these genes in OvLV and other lentiviral infections. Specifically, SYTL3 binds and may regulate RAB27A, which is required for enveloped

  13. Survey of safety practices among hospital laboratories in Oromia Regional State, Ethiopia.

    Science.gov (United States)

    Sewunet, Tsegaye; Kebede, Wakjira; Wondafrash, Beyene; Workalemau, Bereket; Abebe, Gemeda

    2014-10-01

    Unsafe working practices, working environments, disposable waste products, and chemicals in clinical laboratories contribute to infectious and non-infectious hazards. Staffs, the community, and patients are less safe. Furthermore, such practices compromise the quality of laboratory services. We conducted a study to describe safety practices in public hospital laboratories of Oromia Regional State, Ethiopia. Randomly selected ten public hospital laboratories in Oromia Regional State were studied from Oct 2011- Feb 2012. Self-administered structured questionnaire and observation checklists were used for data collection. The respondents were heads of the laboratories, senior technicians, and safety officers. The questionnaire addressed biosafety label, microbial hazards, chemical hazards, physical/mechanical hazards, personal protective equipment, first aid kits and waste disposal system. The data was analyzed using descriptive analysis with SPSS version16 statistical software. All of the respondents reported none of the hospital laboratories were labeled with the appropriate safety label and safety symbols. These respondents also reported they may contain organisms grouped under risk group IV in the absence of microbiological safety cabinets. Overall, the respondents reported that there were poor safety regulations or standards in their laboratories. There were higher risks of microbial, chemical and physical/mechanical hazards. Laboratory safety in public hospitals of Oromia Regional State is below the standard. The laboratory workers are at high risk of combined physical, chemical and microbial hazards. Prompt recognition of the problem and immediate action is mandatory to ensure safe working environment in health laboratories.

  14. Resting-state, functional MRI on regional homogeneity changes of brain in the heavy smokers

    International Nuclear Information System (INIS)

    Yang Shiqi; Wu Guangyao; Lin Fuchun; Kong Xiangquan; Zhou Guofeng; Pang Haopeng; Zhu Ling; Liu Guobing; Lei Hao

    2012-01-01

    Objective: To explore the mechanism of self-awareness in the heavy smokers (HS) by using regional homogeneity (ReHo) combined with resting-state functional MRI (fMRI). Methods: Thirty HS and 31 healthy non-smokers (NS) matched for age and sex underwent a 3.0 T resting-state fMRI. The data were post-processed by SPM 5 and then the ReHo values were calculated by REST software. The ReHo values between the two groups were compared by two-sample t-test. The brain map with significant difference of ReHo value was obtained. Results: Compared with that in NS group, the regions with decreased ReHo value included the bilateral precuneus, superior frontal gyrus,medial prefrontal cortex, right angular gyrus, inferior frontal gyrus, inferior occipital gyrus, cerebellum, and left middle frontal gyrus in HS group. The regions of increased ReHo value included the bilateral insula, parahippocampal gyrus, white matter of parietal lobe, pons, left inferior parietal lobule, lingual gyrus, thalamus, inferior orbital gyrus, white matter of temporal-frontal lobe, and cerebellum. The difference was more obvious in the left hemisphere. Conclusions: In HS, abnormal ReHo on a resting state which reflects network of smoking addiction. This method may be helpful in understanding the mechanism of self-awareness in HS. (authors)

  15. How “European” is the Italian Regional State now? A study on the Europeanization of the Italian Regional System

    Directory of Open Access Journals (Sweden)

    Giuseppe Martinico

    2011-10-01

    Full Text Available To what extent do Italian courts adapt the national legal instruments (principles,rules, techniques, legal concepts regarding state structure to therequirements of EU law? This paper aims to give an answer to this questionby providing an overview of the most emblematic cases of “re-adaptations”operated by the Italian courts in order to ensure the respect of the structuralprinciples of EU law. This contribution is structured as follows: first, Iwill explain the reasons why research like this is “difficult”, while secondlyI will move to the analysis of the of some legal instruments (principle ofcompetence, substitutive power, “cedevolezza”. Some final remarks willbe presented at the end of the paper. Generally speaking, my main idea isthat EU law has had a certain impact on the relationship between Stateand Regions in Italy, especially looking at the seasons of the principle ofcompetence, that has been conceived more and more as referring to theidea of “legislative preference” rather than as to the existence of a “legislativereserved domain”.

  16. Regional impacts of oil and gas development on ozone formation in the western United States.

    Science.gov (United States)

    Rodriguez, Marco A; Barna, Michael G; Moore, Tom

    2009-09-01

    The Intermountain West is currently experiencing increased growth in oil and gas production, which has the potential to affect the visibility and air quality of various Class I areas in the region. The following work presents an analysis of these impacts using the Comprehensive Air Quality Model with extensions (CAMx). CAMx is a state-of-the-science, "one-atmosphere" Eulerian photochemical dispersion model that has been widely used in the assessment of gaseous and particulate air pollution (ozone, fine [PM2.5], and coarse [PM10] particulate matter). Meteorology and emissions inventories developed by the Western Regional Air Partnership Regional Modeling Center for regional haze analysis and planning are used to establish an ozone baseline simulation for the year 2002. The predicted range of values for ozone in the national parks and other Class I areas in the western United States is then evaluated with available observations from the Clean Air Status and Trends Network (CASTNET). This evaluation demonstrates the model's suitability for subsequent planning, sensitivity, and emissions control strategy modeling. Once the ozone baseline simulation has been established, an analysis of the model results is performed to investigate the regional impacts of oil and gas development on the ozone concentrations that affect the air quality of Class I areas. Results indicate that the maximum 8-hr ozone enhancement from oil and gas (9.6 parts per billion [ppb]) could affect southwestern Colorado and northwestern New Mexico. Class I areas in this region that are likely to be impacted by increased ozone include Mesa Verde National Park and Weminuche Wilderness Area in Colorado and San Pedro Parks Wilderness Area, Bandelier Wilderness Area, Pecos Wilderness Area, and Wheeler Peak Wilderness Area in New Mexico.

  17. Association of State Recreational Marijuana Laws With Adolescent Marijuana Use.

    Science.gov (United States)

    Cerdá, Magdalena; Wall, Melanie; Feng, Tianshu; Keyes, Katherine M; Sarvet, Aaron; Schulenberg, John; O'Malley, Patrick M; Pacula, Rosalie Liccardo; Galea, Sandro; Hasin, Deborah S

    2017-02-01

    Historical shifts are occurring in marijuana policy. The effect of legalizing marijuana for recreational use on rates of adolescent marijuana use is a topic of considerable debate. To examine the association between the legalization of recreational marijuana use in Washington and Colorado in 2012 and the subsequent perceived harmfulness and use of marijuana by adolescents. We used data of 253 902 students in eighth, 10th, and 12th grades from 2010 to 2015 from Monitoring the Future, a national, annual, cross-sectional survey of students in secondary schools in the contiguous United States. Difference-in-difference estimates compared changes in perceived harmfulness of marijuana use and in past-month marijuana use in Washington and Colorado prior to recreational marijuana legalization (2010-2012) with postlegalization (2013-2015) vs the contemporaneous trends in other states that did not legalize recreational marijuana use in this period. Perceived harmfulness of marijuana use (great or moderate risk to health from smoking marijuana occasionally) and marijuana use (past 30 days). Of the 253 902 participants, 120 590 of 245 065(49.2%) were male, and the mean (SD) age was 15.6 (1.7) years. In Washington, perceived harmfulness declined 14.2% and 16.1% among eighth and 10th graders, respectively, while marijuana use increased 2.0% and 4.1% from 2010-2012 to 2013-2015. In contrast, among states that did not legalize recreational marijuana use, perceived harmfulness decreased by 4.9% and 7.2% among eighth and 10th graders, respectively, and marijuana use decreased by 1.3% and 0.9% over the same period. Difference-in-difference estimates comparing Washington vs states that did not legalize recreational drug use indicated that these differences were significant for perceived harmfulness (eighth graders: % [SD], -9.3 [3.5]; P = .01; 10th graders: % [SD], -9.0 [3.8]; P = .02) and marijuana use (eighth graders: % [SD], 5.0 [1.9]; P = .03; 10th graders

  18. Review: Regional groundwater flow modeling in heavily irrigated basins of selected states in the western United States

    Science.gov (United States)

    Rossman, Nathan R.; Zlotnik, Vitaly A.

    2013-09-01

    Water resources in agriculture-dominated basins of the arid western United States are stressed due to long-term impacts from pumping. A review of 88 regional groundwater-flow modeling applications from seven intensively irrigated western states (Arizona, California, Colorado, Idaho, Kansas, Nebraska and Texas) was conducted to provide hydrogeologists, modelers, water managers, and decision makers insight about past modeling studies that will aid future model development. Groundwater models were classified into three types: resource evaluation models (39 %), which quantify water budgets and act as preliminary models intended to be updated later, or constitute re-calibrations of older models; management/planning models (55 %), used to explore and identify management plans based on the response of the groundwater system to water-development or climate scenarios, sometimes under water-use constraints; and water rights models (7 %), used to make water administration decisions based on model output and to quantify water shortages incurred by water users or climate changes. Results for 27 model characteristics are summarized by state and model type, and important comparisons and contrasts are highlighted. Consideration of modeling uncertainty and the management focus toward sustainability, adaptive management and resilience are discussed, and future modeling recommendations, in light of the reviewed models and other published works, are presented.

  19. Regional decline of an iconic amphibian associated with elevation, land-use change, and invasive species.

    Science.gov (United States)

    Johnson, Pieter T J; McKenzie, Valerie J; Peterson, Anna C; Kerby, Jacob L; Brown, Jennifer; Blaustein, Andrew R; Jackson, Tina

    2011-06-01

    Ecological theory predicts that species with restricted geographic ranges will have the highest probability of extinction, but species with extensive distributions and high population densities can also exhibit widespread population losses. In the western United States populations of northern leopard frogs (Lithobates pipiens)-historically one of the most widespread frogs in North America-have declined dramatically in abundance and geographic distribution. To assess the status of leopard frogs in Colorado and evaluate causes of decline, we coupled statewide surveys of 196 historically occupied sites with intensive sampling of 274 wetlands stratified by land use. We used an information-theoretic approach to evaluate the contributions of factors at multiple spatial extents in explaining the contemporary distribution of leopard frogs. Our results indicate leopard frogs have declined in Colorado, but this decline was regionally variable. The lowest proportion of occupied wetlands occurred in eastern Colorado (2-28%), coincident with urban development and colonization by non-native bullfrogs (Lithobates catesbeianus). Variables at several spatial extents explained observed leopard frog distributional patterns. In low-elevation wetlands introduced fishes, bullfrogs, and urbanization or suburbanization associated negatively with leopard frog occurrence, whereas wetland area was positively associated with occurrence. Leopard frogs were more abundant and widespread west of the Continental Divide, where urban development and bullfrog abundance were low. Although the pathogenic chytrid Batrachochytrium dendrobatidis (Bd) was not selected in our best-supported models, the nearly complete extirpation of leopard frogs from montane wetlands could reflect the individual or interactive effects of Bd and climate patterns. Our results highlight the importance of considering multiple, competing hypotheses to explain species declines, particularly when implicated factors operate at

  20. 77 FR 24392 - Approval and Promulgation of Implementation Plans; Tennessee; Regional Haze State Implementation...

    Science.gov (United States)

    2012-04-24

    ... ), and in some cases, ammonia and volatile organic compounds. Fine particle precursors react in the... compliance associated with wet scrubbers in evaluating possible BART controls. The State determined that the capital costs and control costs for the wet scrubbers were approximately $200,000,000 and $39,000,000...

  1. The regulatory role of the state strategic management in the development of the regional entrepreneurial sphere

    Directory of Open Access Journals (Sweden)

    Yukhneva Nina

    2017-01-01

    Full Text Available The system of state strategic management (SGSO today is an Outpost of the state, exercising the functions of strategic management, development and predicates, and conducting an evaluation of the effectiveness and quality of the planned trajectories of economic development of the regions, regions and the state as a whole. It SGSW today is designed to ensure that the nationally oriented domestic policies that contribute to progressive and bold actions of the Russian Federation on the world stage. SHSU today is to create conditions for the development of science, research training, new knowledge-based economy. SHSU should form a system of state orders, which is of fundamental importance for the development of strategic projects in the field of medicine and health, agriculture, defense industry, etc. And, most importantly, SHSU needs today and support the process of re-industrialization of the country, technical re-equipment of all areas of production and management. In the new knowledge economy SHSU performs the role of the intellectual and information center regulation and strategic planning of development of the entire socio-economic sphere of the society centre to ensure the development of a database of fundamental and applied research, development, centre, guaranteeing the protection of copyright and introduction of innovative products, including new technical and technological solutions.

  2. Search for molecular outflows associated with peculiar nebulosities and regions of star formation

    Energy Technology Data Exchange (ETDEWEB)

    Torrelles, J M; Rodriguez, L F; Canto, J; Marcaide, J; Gyulbudaghian, A L

    1983-01-01

    We surveyed an extensive list of peculiar nebulosities and regions of star formation searching for conspicuous cases of high-velocity carbon monoxide emission. We detected an apparently isotropic outflow associated with the star-forming region GL 2591. Among the other sources surveyed, the cometary nebula GM 24 is of interest since it is located in a very hot molecular spot where formation of massive stars took place recently.

  3. Association of the FAM167A-BLK region with systemic sclerosis.

    Science.gov (United States)

    Ito, Ikue; Kawaguchi, Yasushi; Kawasaki, Aya; Hasegawa, Minoru; Ohashi, Jun; Kawamoto, Manabu; Fujimoto, Manabu; Takehara, Kazuhiko; Sato, Shinichi; Hara, Masako; Tsuchiya, Naoyuki

    2010-03-01

    An association of single-nucleotide polymorphisms (SNPs) in the FAM167A (previously referred to as C8orf13)-BLK region with systemic lupus erythematosus (SLE) has been demonstrated in Caucasians and in Asians. Recent studies have shown that many genes, including IRF5, STAT4, and PTPN22, are shared susceptibility genes in multiple autoimmune diseases. We undertook the current study to examine whether the FAM167A-BLK region is also associated with susceptibility to systemic sclerosis (SSc). Japanese patients with SSc (n = 309) and healthy controls (n = 769) were enrolled in a 2-tiered case-control association study. In tier 1, 124 patients and 412 controls were tested to determine association of 16 tag SNPs encompassing the FAM167A-BLK region with SSc. In tier 2, an additional 185 patients and 357 controls were analyzed for SNP rs13277113. Two haplotype blocks that correspond approximately to FAM167A and BLK were observed. In tier 1 of the study, the rs13277113A allele in the BLK block exhibited the most significant association with SSc after correction for multiple testing (permutated P = 0.024). Two SNP haplotypes formed by rs13277113 and the most significant SNP in the FAM167A block did not exhibit stronger association. When samples from tier 1 and tier 2 were combined, the rs13277113A allele was significantly associated with SSc (odds ratio 1.45 [95% confidence interval 1.17-1.79], P = 6.1 x 10(-4)). Association or a tendency toward association of rs13277113A with SSc was observed regardless of a patient's autoantibody profile or whether a patient had diffuse cutaneous or limited cutaneous SSc. Our findings indicate that the rs13277113A allele is associated not only with SLE but also with SSc and that the FAM167A-BLK region is a common genetic risk factor for both SLE and SSc.

  4. Automatic detection of the hippocampal region associated with Alzheimer's disease from microscopic images of mice brain

    Science.gov (United States)

    Albaidhani, Tahseen; Hawkes, Cheryl; Jassim, Sabah; Al-Assam, Hisham

    2016-05-01

    The hippocampus is the region of the brain that is primarily associated with memory and spatial navigation. It is one of the first brain regions to be damaged when a person suffers from Alzheimer's disease. Recent research in this field has focussed on the assessment of damage to different blood vessels within the hippocampal region from a high throughput brain microscopic images. The ultimate aim of our research is the creation of an automatic system to count and classify different blood vessels such as capillaries, veins, and arteries in the hippocampus region. This work should provide biologists with efficient and accurate tools in their investigation of the causes of Alzheimer's disease. Locating the boundary of the Region of Interest in the hippocampus from microscopic images of mice brain is the first essential stage towards developing such a system. This task benefits from the variation in colour channels and texture between the two sides of the hippocampus and the boundary region. Accordingly, the developed initial step of our research to locating the hippocampus edge uses a colour-based segmentation of the brain image followed by Hough transforms on the colour channel that isolate the hippocampus region. The output is then used to split the brain image into two sides of the detected section of the boundary: the inside region and the outside region. Experimental results on a sufficiently number of microscopic images demonstrate the effectiveness of the developed solution.

  5. Prevalence and associated risk factors for bovine brucellosis in the State of Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Erivânia Camelo de Almeida

    2016-11-01

    Full Text Available This study was conducted to characterize the epidemiology of bovine brucellosis in the state of Pernambuco, Brazil. The state was divided into three regions, and in each region, approximately 300 properties were randomly sampled. From these selected properties, a pre-established number of animals were randomly selected and blood serum samples were obtained. A total of 3,901 animals were selected from 900 properties. For each selected property, an epidemiological questionnaire was administered to assess the type of farming, the animal husbandry practices and the sanitary practices that could be associated with the presence of brucellosis infection. The testing protocol consisted of screening the samples with a buffered acidified plate antigen test and retesting the positive samples with a complement fixation test (CF. One positive animal was enough to define an infected herd. The prevalence rates of infected herds and animals in the state were 4.5% [3.2; 6.4%] and 1.4% [0.7; 2.7%], respectively. By region, the prevalence rates of infected herds and animals, respectively, were as follows: Zona da Mata, 3.3% [1.8; 6.1%] and 1.7% [0.5; 3.0%]; Agreste, 7.4% [4.9; 10.9%] and 1.9% [0.8; 3.0%]; and Sertão, 1.3% [0.5; 3.5%] and 0.7% [0.0; 1.6%]. Flooded pastures (OR = 2.86 [1.37; 6.42] and the presence of 13 or more females in the herd (3rd quartile (OR = 2.65 [1.19; 5.89] were identified as risk factors. The existence of veterinary care emerged as a protective factor against bovine brucellosis in the state of Pernambuco (OR = 0.24 [0.10; 0.58].

  6. Pathways of fish invasions in the Mid-Atlantic region of the United States

    Science.gov (United States)

    Lapointe, Nicolas W. R.; Fuller, Pam; Neilson, Matthew; Murphy, Brian R.; Angermeier, Paul

    2016-01-01

    Non-native fish introductions are a major threat to biodiversity and fisheries, and occur through numerous pathways that vary regionally in importance. A key strategy for managing invasions is to focus prevention efforts on pathways posing the greatest risk of future introductions. We identified high-risk pathways for fish establishment in the Mid-Atlantic region of the United States based on estimates of probability of establishment and records of previous introductions, which were considered in the context of emerging socioeconomic trends. We used estimates of propagule pressure, species’ environmental tolerance, and size of species pool to assess the risk of establishment by pathway. Pathways varied considerably in historic importance and species composition, with the majority of species introduced intentionally via stocking (primarily for sport, forage, or biocontrol) or bait release. Bait release, private stocking, illegal introductions intended to establish reproducing populations (e.g., of sport fish), aquaculture, and the sale of live organisms all create risks for future invasions in the Mid-Atlantic region. Of these pathways, bait release probably poses the greatest risk of introductions for the Mid-Atlantic region because propagule pressure is moderate, most released species are tolerant of local environmental conditions, and the pool of species available for transplantation is large. Our findings differ considerably from studies in other regions (e.g., bait release is a dominant pathway in the Mid-Atlantic region, whereas illegal introduction of sport fish is dominant in the western US and aquarium releases are dominant in Florida), demonstrating the need for regional-scale assessments of, and management strategies for, introduction pathways.

  7. High-resolution, regional-scale crop yield simulations for the Southwestern United States

    Science.gov (United States)

    Stack, D. H.; Kafatos, M.; Medvigy, D.; El-Askary, H. M.; Hatzopoulos, N.; Kim, J.; Kim, S.; Prasad, A. K.; Tremback, C.; Walko, R. L.; Asrar, G. R.

    2012-12-01

    Over the past few decades, there have been many process-based crop models developed with the goal of better understanding the impacts of climate, soils, and management decisions on crop yields. These models simulate the growth and development of crops in response to environmental drivers. Traditionally, process-based crop models have been run at the individual farm level for yield optimization and management scenario testing. Few previous studies have used these models over broader geographic regions, largely due to the lack of gridded high-resolution meteorological and soil datasets required as inputs for these data intensive process-based models. In particular, assessment of regional-scale yield variability due to climate change requires high-resolution, regional-scale, climate projections, and such projections have been unavailable until recently. The goal of this study was to create a framework for extending the Agricultural Production Systems sIMulator (APSIM) crop model for use at regional scales and analyze spatial and temporal yield changes in the Southwestern United States (CA, AZ, and NV). Using the scripting language Python, an automated pipeline was developed to link Regional Climate Model (RCM) output with the APSIM crop model, thus creating a one-way nested modeling framework. This framework was used to combine climate, soil, land use, and agricultural management datasets in order to better understand the relationship between climate variability and crop yield at the regional-scale. Three different RCMs were used to drive APSIM: OLAM, RAMS, and WRF. Preliminary results suggest that, depending on the model inputs, there is some variability between simulated RCM driven maize yields and historical yields obtained from the United States Department of Agriculture (USDA). Furthermore, these simulations showed strong non-linear correlations between yield and meteorological drivers, with critical threshold values for some of the inputs (e.g. minimum and

  8. Distributional impacts of state-level energy efficiency policies in regional electricity markets

    International Nuclear Information System (INIS)

    Sahraei-Ardakani, Mostafa; Blumsack, Seth; Kleit, Andrew

    2012-01-01

    A number of U.S. states have passed legislation targeting energy efficiency and peak demand reduction. We study one such state, Pennsylvania, within the context of PJM, a regional electricity market covering numerous different states. Our focus is on the distributive impacts of this policy—specifically how the policy is likely to impact electricity prices in different areas of Pennsylvania and in the PJM market more generally. Such spatial differences in policy impacts are difficult to model and the transmission system is often ignored in policy studies. Our model estimates supply curves on a “zonal” basis within regional electricity markets and yields information on price and fuel utilization within each zone. We use the zonal supply curves estimated by our model to study regional impacts of energy-efficiency legislation on utilities both inside and outside of Pennsylvania. For most utilities in Pennsylvania, it would reduce the influence of natural gas on electricity price formation and increase the influence of coal. It would also save 2.1 to 2.8 percent of total energy cost in Pennsylvania in a year similar to 2009. The savings are lower than 0.5 percent in other PJM states and the prices may slightly increase in Washington, DC area. - Highlights: ► We model distributional impacts of energy efficiency and conservation policies. ► We use our model to study the impacts of Pennsylvania act 129. ► We estimate $235 million in annual savings for PA and $275 million for PJM. ► The prices decrease in most of the zones but the impacts are not uniform. ► The influence of coal on electricity prices increases relative to natural gas.

  9. Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study.

    Science.gov (United States)

    Yin, Zhaoxue; Chen, Jing; Zhang, Jian; Ren, Zeping; Dong, Kui; Kraus, Virginia B; Wang, Zhuoqun; Zhang, Mei; Zhai, Yi; Song, Pengkun; Zhao, Yanfang; Pang, Shaojie; Mi, Shengquan; Zhao, Wenhua

    2018-04-09

    Although dietary patterns are crucial to cognitive function, associations of dietary patterns with cognitive function have not yet been fully understood. This cross-sectional study explored dietary patterns associated with cognitive function among the older adults in underdeveloped regions, using 1504 community-dwelling older adults aged 60 and over. Diet was assessed using a food frequency questionnaire and 24-h dietary recall. Factor analysis was used to extract dietary patterns. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE). Two dietary patterns, a "mushroom, vegetable, and fruits" (MVF) pattern and a "meat and soybean products" (MS) pattern, were identified. The MVF pattern, characterized by high consumption of mushrooms, vegetables, and fruits was significantly positively associated with cognitive function ( p cognitive impairment and β (95% CIs) 0.15 (0.02, 0.29) for -log (31-MMSE score). The MS pattern, characterized by high consumption of soybean products and meat, was also associated with better cognitive function, with an odds ratio of 0.47 (95% CIs 0.30, 0.74) for cognitive impairment and β (95% CIs) 0.34 (0.21, 0.47) for -log (31-MMSE score). Our results suggested that both the MVF and MS patterns were positively associated with better cognitive function among older adults in underdeveloped regions.

  10. Methodologies Used by Midwest Region States for Studying Teacher Supply and Demand. Issues & Answers. REL 2009-080

    Science.gov (United States)

    Lindsay, James J.; Wan, Yinmei; Gossin-Wilson, Will

    2009-01-01

    This report describes how state education agencies in the Midwest Region monitor teacher supply, demand, and shortage; details why they monitor these data; and offers estimates of the monetary costs incurred in performing such studies. This study responds to a request from state education agencies in the Midwest Region (Illinois, Indiana, Iowa,…

  11. 40 CFR 109.5 - Development and implementation criteria for State, local and regional oil removal contingency plans.

    Science.gov (United States)

    2010-07-01

    ... regional oil removal contingency plans. Criteria for the development and implementation of State, local and... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Development and implementation criteria for State, local and regional oil removal contingency plans. 109.5 Section 109.5 Protection of...

  12. 20 CFR 661.290 - Under what circumstances may States require Local Boards to take part in regional planning...

    Science.gov (United States)

    2010-04-01

    ... what circumstances may States require Local Boards to take part in regional planning activities? (a... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances may States require Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits...

  13. 76 FR 32986 - Vendor Outreach Workshop for Small Businesses in the Texas Intermountain Region of the United States

    Science.gov (United States)

    2011-06-07

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Vendor Outreach Workshop for Small Businesses in the Texas Intermountain Region of the United States AGENCY: Office of the Secretary, Interior... region of the United States that are interested in doing business with the Department. This outreach...

  14. 76 FR 7839 - Notice of Commission and Commission Staff Attendance at ISO/RTO Council and Regional State...

    Science.gov (United States)

    2011-02-11

    ... Staff Attendance at ISO/RTO Council and Regional State Committees Meeting The Federal Energy Regulatory... ISO/RTO Council and Regional State Committees meeting: Saturday, February 12, 2011, 1 p.m.-4 p.m... following proceeding: Docket No. AD10-5-000, RTO/ISO Performance Metrics. For more information, contact...

  15. Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy.

    Science.gov (United States)

    Ceschin, Rafael; Lee, Vince K; Schmithorst, Vince; Panigrahy, Ashok

    2015-01-01

    Preterm born children with spastic diplegia type of cerebral palsy and white matter injury or periventricular leukomalacia (PVL), are known to have motor, visual and cognitive impairments. Most diffusion tensor imaging (DTI) studies performed in this group have demonstrated widespread abnormalities using averaged deterministic tractography and voxel-based DTI measurements. Little is known about structural network correlates of white matter topography and reorganization in preterm cerebral palsy, despite the availability of new therapies and the need for brain imaging biomarkers. Here, we combined novel post-processing methodology of probabilistic tractography data in this preterm cohort to improve spatial and regional delineation of longitudinal cortical association tract abnormalities using an along-tract approach, and compared these data to structural DTI cortical network topology analysis. DTI images were acquired on 16 preterm children with cerebral palsy (mean age 5.6 ± 4) and 75 healthy controls (mean age 5.7 ± 3.4). Despite mean tract analysis, Tract-Based Spatial Statistics (TBSS) and voxel-based morphometry (VBM) demonstrating diffusely reduced fractional anisotropy (FA) reduction in all white matter tracts, the along-tract analysis improved the detection of regional tract vulnerability. The along-tract map-structural network topology correlates revealed two associations: (1) reduced regional posterior-anterior gradient in FA of the longitudinal visual cortical association tracts (inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, optic radiation, posterior thalamic radiation) correlated with reduced posterior-anterior gradient of intra-regional (nodal efficiency) metrics with relative sparing of frontal and temporal regions; and (2) reduced regional FA within frontal-thalamic-striatal white matter pathways (anterior limb/anterior thalamic radiation, superior longitudinal fasciculus and cortical spinal tract) correlated with

  16. Mortality trends and risk of dying from pulmonary tuberculosis in the 7 socioeconomic regions and the 32 States of Mexico, 2000-2009.

    Science.gov (United States)

    Sánchez-Barriga, Juan Jesús

    2015-01-01

    Tuberculosis (TB) is a world public health problem that still has a high morbidity and mortality rate mainly in countries with significant wealth gaps. Poverty, malnutrition, HIV infection, drug resistance, diabetes and addictions (mainly alcoholism) have been seen to contribute to the persistence of TB as an important health problem in Mexico. Death certificates associated with pulmonary tuberculosis (PTB) for 2000-2009 were obtained from the National Information System of the Secretariat of Health. Rates of mortality nationwide, by state, and by socioeconomic region were calculated. The strength of association between states where individuals resided, socioeconomic regions, and education with mortality from PTB was determined. Age-adjusted mortality rates per 100,000 inhabitants who died from PTB decreased from 4.1 to 2 between 2000 and 2009. Men (67.7%) presented higher mortality than women (32.3%). Individuals failing to complete elementary education presented a higher risk of dying from PTB (RR 1.08 [95%CI: 1.05-1.12]). The socioeconomic region and the entities with the strongest association were region 1, 5, Chiapas and Baja California. Region 1 in 2007 presented RR 7.34 (95%CI: 5.32-10.13), and region 5 in 2009 had RR 10.08 (95%CI: 6.83-14.88). In Mexico, the annual mortality rate from PTB decreased. Men presented higher mortality than women. Individuals failing to complete elementary education showed a higher risk of dying from PTB. The states and regions of Mexico that presented a stronger association with mortality from PTB were Chiapas and Baja California, region 1 and 5. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

  17. [State of collective immunity against poliomyelitis in some regions of Russia].

    Science.gov (United States)

    Seĭbil', V B; Malyshkina, L P; Khishtova, S N; Lesnikova, M V; Baryshnikova, A S; Konopleva, T N; Mnozhina, E G; Agafonova, T V; Vladimirova, L A

    2013-01-01

    Study the state of collective immunity against poliomyelitis in 7 regions of Russia in the last 3 years. 2579 sera were studied for antibodies against poliomyelitis virus. Antibodies (AT) against 3 types of viruses were determined in neutralization reaction in RD cell culture, the state of collective immunity in the examined individuals was evaluated by the percent of individuals with AT against a type of poliovirus and geometric mean AT titer. The circulation of wild polioviruses was judged by the presence of strain specific AT against wild and vaccine viruses in the examined children (311 sera were studied). The indicators of collective immunity against poliomyelitis in both select examined regions and select age groups were generally high. The data obtained allow to make a conclusion that the quality of vaccine prophylaxis in the examined regions is good. Introduction of wild poliovirus type 1 from Tajikistan in 2010 caused disease in 7 residents of Russia whereas an epidemic that had affected more than 700 individuals emerged in Tajikistan. The studies carried out confirmed the necessity to continue qualitative poliomyelitis vaccine prophylaxis in the country despite the lack of circulation of wild polioviruses that can be introduced at any time.

  18. Regional differences in right versus left congenital heart disease diagnoses in neonates in the United States.

    Science.gov (United States)

    Nelson, Jennifer S; Strassle, Paula D

    2018-03-01

    Differences in the prevalence of left and right congenital heart defects (CHD) across the United States are unclear. This study evaluated the overall prevalence and the distribution of right versus left CHD across US regions and divisions in neonates. Newborns born from 2000 to 2014 diagnosed with CHD were identified using the National Inpatient Sample. Heart defects were stratified into right, left, and "neither" subtypes. The risk of right and left heart diagnoses between US Census regions and divisions was compared using multivariable binomial regression, adjusting for infant, and hospital characteristics. Two hundred forty thousand four hundred fifty-five newborns were included and 38,185 (15.9%) were classifiable as having either right or left subtypes. Between 2000 and 2014, the prevalence of right defects increased from 1.65 to 2.88 cases/1,000 live born infants (p right heart defect diagnosis compared to the West. When stratified by division, New England states had a significantly higher prevalence of right defects compared to the Pacific (RD adj .09, 95% CI .06, 0.11). No differences in the prevalence of left defects were seen. The prevalence of CHD diagnoses at birth in the US has increased, and regional differences in the prevalence of right defects appear to exist. © 2017 Wiley Periodicals, Inc.

  19. Communal spaces: aggregation and integration in the Mogollon Region of the United States Southwest

    Energy Technology Data Exchange (ETDEWEB)

    Nisengard, Jennifer E.

    2006-12-01

    Aggregation and integration are processes that occur in human societies throughout the globe. An informative example of population aggregation and social integration can be observed in the North American desert borderlands from A.D. 250 to 1450 in the area known as the Mogollon region. In fact, Mogollon communities oscillated from smaller social groups into larger ones and dispersed into smaller groups only to form larger ones again. For this reason, examining the groups of people living in the Mogollon region provides a magnified view of social change over a substantial period. Understanding patterns of aggregation and integration provides researchers with the promise for research into the nature of these phenomena. In general, the Mogollon region is characterized by limited water supplies and low average annual precipitation. However, pockets of the Mogollon area, including the Mimbres valley and the Gila River valley, represent oases, where permanent rivers and their associated tributaries allowed for the pursuit of agricultural endeavors and access to a wide variety of wild plant and animal resources. The areas with these kinds of potential became population centers for previously dispersed groups of people living in the region. These people exploited natural resources and practiced agriculture in areas surrounding their communities. Over time, more organized aggregated and socially integrated communities were established throughout the region. Using ancient Mogollon communal architecture, commonly called kivas, this study examines issues of, and evidence for, population aggregation and social integration.

  20. Mental health problems in a regional population of Australian adolescents: association with socio-demographic characteristics

    OpenAIRE

    Dray, Julia; Bowman, Jenny; Freund, Megan; Campbell, Elizabeth; Hodder, Rebecca K.; Lecathelinais, Christophe; Wiggers, John

    2016-01-01

    Background Population level data regarding the general mental health status, and the socio-demographic factors associated with the mental health status of adolescents in Australia aged 12?16?years is limited. This study assessed prevalence of mental health problems in a regional population of Australian students in Grades 7?10, and investigated associations between mental health problems and socio-demographic factors. Methods A web-based survey was conducted in 21 secondary schools located in...

  1. Influence of Professional Associations on Regional Policy in Education: International Experience

    Directory of Open Access Journals (Sweden)

    Svetlana Tezikova

    2013-08-01

    Full Text Available On the basis of the organizational development analisys, as well as literature review and author’s participation in the European and American professional associations the main ideas to establish the ratio between regional government bodies and non-profit organisations are proposed. The historical-pedagogical review of teachers’associations permitted to define organizational conditions for teacher professional developmen and they are represented in the article.

  2. The development of state/region owned goods management’s monitoring instrument design

    Directory of Open Access Journals (Sweden)

    Ikhwanto Yogy

    2017-01-01

    Full Text Available The problems in state/region owned goods in Indonesian state and local governments are suspected to occur because of weak monitoring programs, according to many studies. A tool or instrument in implementing this monitoring program is expected to address this problem. Such tool currently doesn’t exist yet. This research aims to fill that gap by developing a monitoring instrument design for state/region owned goods by using Daerah Istimewa Yogyakarta (DIY Local Government as a research context in order to take valuable inputs for the design. This research is using developmental research method. Government Regulation were used for normative reference and Friedman’s results-based accountability quadrat were used in developing good indicators for the instrument. This research is succeeded in formulating the indicators that made up the instrument. Indicators compiled are divided into compliance-based indicators and results-based indicators. Indicators are formulated based on the validation and inputs from employees of DIY’s Assets Management Agency and experts from academia. This instrument still has some limitations that need improvement through further research.

  3. Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution.

    Science.gov (United States)

    Kana, Rajesh K; Keller, Timothy A; Cherkassky, Vladimir L; Minshew, Nancy J; Just, Marcel Adam

    2009-01-01

    This study used fMRI to investigate the functioning of the Theory of Mind (ToM) cortical network in autism during the viewing of animations that in some conditions entailed the attribution of a mental state to animated geometric figures. At the cortical level, mentalizing (attribution of metal states) is underpinned by the coordination and integration of the components of the ToM network, which include the medial frontal gyrus, the anterior paracingulate, and the right temporoparietal junction. The pivotal new finding was a functional underconnectivity (a lower degree of synchronization) in autism, especially in the connections between frontal and posterior areas during the attribution of mental states. In addition, the frontal ToM regions activated less in participants with autism relative to control participants. In the autism group, an independent psychometric assessment of ToM ability and the activation in the right temporoparietal junction were reliably correlated. The results together provide new evidence for the biological basis of atypical processing of ToM in autism, implicating the underconnectivity between frontal regions and more posterior areas.

  4. National and Regional Representativeness of Hospital Emergency Department Visit Data in the National Syndromic Surveillance Program, United States, 2014

    Science.gov (United States)

    Coates, Ralph J.; Pérez, Alejandro; Baer, Atar; Zhou, Hong; English, Roseanne; Coletta, Michael; Dey, Achintya

    2016-01-01

    Objective We examined the representativeness of the nonfederal hospital emergency department (ED) visit data in the National Syndromic Surveillance Program (NSSP). Methods We used the 2012 American Hospital Association Annual Survey Database, other databases, and information from state and local health departments participating in the NSSP about which hospitals submitted data to the NSSP in October 2014. We compared ED visits for hospitals submitting 15 data with all ED visits in all 50 states and Washington, DC. Results Approximately 60.4 million of 134.6 million ED visits nationwide (~45%) were reported to have been submitted to the NSSP. ED visits in 5 of 10 regions and the majority of the states were substantially underrepresented in the NSSP. The NSSP ED visits were similar to national ED visits in terms of many of the characteristics of hospitals and their service areas. However, visits in hospitals with the fewest annual ED visits, in rural trauma centers, and in hospitals serving populations with high percentages of Hispanics and Asians were underrepresented. Conclusions NSSP nonfederal hospital ED visit data were representative for many hospital characteristics and in some geographic areas but were not very representative nationally and in many locations. Representativeness could be improved by increasing participation in more states and among specific types of hospitals. PMID:26883318

  5. Regional approaches to power plant siting in the United States of America

    International Nuclear Information System (INIS)

    DiNunno, J.J.

    1975-01-01

    The selection and evaluation of sites for power plants in the United States of America have become increasingly difficult in recent years as pressures from various societal segments have resulted in governmental restraints on selection and burning of fossil fuels, methods of heat dissipation, acquisition of transmission rights of way, and on environmental impact of industrialization in general. New legislation at both Federal and state levels has been enacted that influences power plant siting. In addition to environmental requirements that must be satisfied, implementing procedures require documented justification for sites chosen and public disclosure of the basis for selection. Some states have consolidated their regulatory activities in the power plant siting area to provide for a more unified approach to these problems. Although nuclear plants have by far the most rigorous requirements for documentation of site selection and plant design, the application of the same general philosophies to fossil plants has been made in several states and can be anticipated elsewhere. Individual site-related investigations have not so much changed in basics as they have been enlarged in scope. Whereas in the past the search for siting alternatives was frequently confined to a utility's service area, the additional siting constraints represented in environmental laws, the economies of size of nuclear power plants, and the sharing of plant capacities among utilities have contributed to a widening of the search area. Several states have assumed the responsibility for site search and investigation and their efforts extend state-wide. This paper discusses applications of regional approaches to power plant siting in the United States of America using case studies made by NUS Corporation, an engineering/environmental consulting firm. The universality of these approaches is indicated, leaving to national policies and goals the importance of values assigned to the basic siting factors

  6. Financial literacy is associated with medial brain region functional connectivity in old age.

    Science.gov (United States)

    Han, S Duke; Boyle, Patricia A; Yu, Lei; Fleischman, Debra A; Arfanakis, Konstantinos; Leurgans, Sue; Bennett, David A

    2014-01-01

    Financial literacy refers to the ability to access and utilize financial information in ways that promote better outcomes. In old age, financial literacy has been associated with a wide range of positive characteristics; however, the neural correlates remain unclear. Recent work has suggested greater co-activity between anterior-posterior medial brain regions is associated with better brain functioning. We hypothesized financial literacy would be associated with this pattern. We assessed whole-brain functional connectivity to a posterior cingulate cortex (PCC) seed region of interest (ROI) in 138 participants of the Rush Memory and Aging Project. Results revealed financial literacy was associated with greater functional connectivity between the PCC and three regions: the right ventromedial prefrontal cortex (vmPFC), the left postcentral gyrus, and the right precuneus. Results also revealed financial literacy was associated negatively with functional connectivity between the PCC and left caudate. Post hoc analyses showed the PCC-vmPFC relationship accounted for the most variance in a regression model adjusted for all four significant functional connectivity relationships, demographic factors, and global cognition. These findings provide information on the neural mechanisms associated with financial literacy in old age. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  7. Cytogenomic Integrative Network Analysis of the Critical Region Associated with Wolf-Hirschhorn Syndrome

    Directory of Open Access Journals (Sweden)

    Thiago Corrêa

    2018-01-01

    Full Text Available Deletions in the 4p16.3 region are associated with Wolf-Hirschhorn syndrome (WHS, a contiguous gene deletion syndrome involving variable size deletions. In this study, we perform a cytogenomic integrative analysis combining classical cytogenetic methods, fluorescence in situ hybridization (FISH, chromosomal microarray analysis (CMA, and systems biology strategies, to establish the cytogenomic profile involving the 4p16.3 critical region and suggest WHS-related intracellular cell signaling cascades. The cytogenetic and clinical patient profiles were evaluated. We characterized 12 terminal deletions, one interstitial deletion, two ring chromosomes, and one classical translocation 4;8. CMA allowed delineation of the deletions, which ranged from 3.7 to 25.6 Mb with breakpoints from 4p16.3 to 4p15.33. Furthermore, the smallest region of overlapping (SRO encompassed seven genes in a terminal region of 330 kb in the 4p16.3 region, suggesting a region of susceptibility to convulsions and microcephaly. Therefore, molecular interaction networks and topological analysis were performed to understand these WHS-related symptoms. Our results suggest that specific cell signaling pathways including dopamine receptor, NAD+ nucleosidase activity, and fibroblast growth factor-activated receptor activity are associated with the diverse pathological WHS phenotypes and their symptoms. Additionally, we identified 29 hub-bottlenecks (H-B nodes with a major role in WHS.

  8. Coordinating across scales: Building a regional marsh bird monitoring program from national and state Initiatives

    Science.gov (United States)

    Shriver, G.W.; Sauer, J.R.

    2008-01-01

    Salt marsh breeding bird populations (rails, bitterns, sparrows, etc.) in eastern North America are high conservation priorities in need of site specific and regional monitoring designed to detect population changes over time. The present status and trends of these species are unknown but anecdotal evidence of declines in many of the species has raised conservation concerns. Most of these species are listed as conservation priorities on comprehensive wildlife plans throughout the eastern U.S. National Wildlife Refuges, National Park Service units, and other wildlife conservation areas provide important salt marsh habitat. To meet management needs for these areas, and to assist regional conservation planning, survey designs are being developed to estimate abundance and population trends for these breeding bird species. The primary purpose of this project is to develop a hierarchical sampling frame for salt marsh birds in Bird Conservation Region (BCR) 30 that will provide the ability to estimate species population abundances on 1) specific sites (i.e. National Parks and National Wildlife Refuges), 2) within states or regions, and 3) within BCR 30. The entire breeding range of Saltmarsh Sharp-tailed and Coastal Plain Swamp sparrows are within BCR 30, providing an opportunity to detect population trends within the entire breeding ranges of two priority species.

  9. Social theory and the region: from the Regional Planning Association of America to the restructuring of sociospatial theory, with policy implications

    OpenAIRE

    R Banai

    1993-01-01

    In this paper an argument is developed in support of the relevance of social theory for the region. Characterized by bridging across conceptual and methodological divides, by the increasing prominence of the role of space, context, and human agency, social theory exhibits an affinity with the regional development theory of the Regional Planning Association of America (RPAA) in the 1920s. This paper provides a brief account of the RPAA's approach to regional synthesis. The author alms to build...

  10. Impacts of Anthropogenic Aerosols on Regional Climate: Extreme Events, Stagnation, and the United States Warming Hole

    Science.gov (United States)

    Mascioli, Nora R.

    Extreme temperatures, heat waves, heavy rainfall events, drought, and extreme air pollution events have adverse effects on human health, infrastructure, agriculture and economies. The frequency, magnitude and duration of these events are expected to change in the future in response to increasing greenhouse gases and decreasing aerosols, but future climate projections are uncertain. A significant portion of this uncertainty arises from uncertainty in the effects of aerosol forcing: to what extent were the effects from greenhouse gases masked by aerosol forcing over the historical observational period, and how much will decreases in aerosol forcing influence regional and global climate over the remainder of the 21st century? The observed frequency and intensity of extreme heat and precipitation events have increased in the U.S. over the latter half of the 20th century. Using aerosol only (AER) and greenhouse gas only (GHG) simulations from 1860 to 2005 in the GFDL CM3 chemistry-climate model, I parse apart the competing influences of aerosols and greenhouse gases on these extreme events. I find that small changes in extremes in the "all forcing" simulations reflect cancellations between the effects of increasing anthropogenic aerosols and greenhouse gases. In AER, extreme high temperatures and the number of days with temperatures above the 90th percentile decline over most of the U.S., while in GHG high temperature extremes increase over most of the U.S. The spatial response patterns in AER and GHG are significantly anti-correlated, suggesting a preferred regional mode of response that is largely independent of the type of forcing. Extreme precipitation over the eastern U.S. decreases in AER, particularly in winter, and increases over the eastern and central U.S. in GHG, particularly in spring. Over the 21 st century under the RCP8.5 emissions scenario, the patterns of extreme temperature and precipitation change associated with greenhouse gas forcing dominate. The

  11. Intercomparison of four regional climate models for the German State of Saxonia

    Science.gov (United States)

    Kreienkamp, F.; Spekat, A.; Enke, W.

    2009-09-01

    Results from four regional climate models which focus on Central Europe are presented: CCLM, the climate version of the German Weather Service's Local Model - REMO, the regional dynamic model from the Max Planck Institute for Meteorology in Hamburg - STAR, the statistical model developed at the PIK Potsdam Institute and WETTREG, the statistic-dynamic model developed by the company CEC Potsdam. For the area of the German State of Saxonia a host of properties and indicators were analyzed aiming to show the models' abilities to reconstruct the current climate and compare climate model scenarios. These include a group of thermal indicators, such as the number of ice, frost, summer and hot days, the number of tropical nights; then there are hydrometeorological indicators such as the exceedance of low and high precipitation thresholds; humidity, cloudiness and wind indicators complement the array. A selection of them showing similarities and differences of the models investigated will be presented.

  12. Arsenic content of soils from three regions of Santa Catarina State

    Directory of Open Access Journals (Sweden)

    Leticia Cristina de Souza

    2016-03-01

    Full Text Available The determination of trace elements is necessary in order to monitor their entry into the soil system and to remediate contaminated areas. The purpose of this study was to determine the natural content of arsenic (As in soils of three regions of Santa Catarina State (SC: the Southern Plateau, the Metropolitan area and the Southern Coast. Arsenic content was obtained after digestion in a microwave oven, following the USEPA 3051 A protocol and quantification was made by atomic absorption spectrometry with electrothermal atomization. The results were analyzed by the Scott-Knott test at a 5% significance level. Soil attributes that best correlated with arsenic content were clay, organic carbon, cation exchange capacity and Al and Fe oxides. The arsenic levels are related to the source material and the slope of regional soils.

  13. Anti pp annihilations into four- and five-pion final states in the T(2190) region

    International Nuclear Information System (INIS)

    Handler, T.; Jacques, P.; Jones, M.; Pandoulas, D.; Plano, R.J.; Preissner, H.; Sheng, A.P.; Watts, T.L.; Yamin, P.; Brucker, E.B.; Koller, E.L.; Taylor, S.; Stamer, P.; Sun, C.R.; Dhar, S.

    1975-01-01

    New data from a 600 000 picture exposure of the BNL 31 inch hydrogen bubble chamber to a separated antiproton beam have been analyzed to try to determine if the π + π - π + π - or π + π - π + π - π 0 final states contribute any broad or narrow structure in the T(2190) region. The resonance channel fractions determined by maximum likelihood fits are all consistent with smooth behavior through the T-region and therefore there is no significant evidence that any of these resonance channels contributes to the broad bump in the total cross section. The errors on some of the fractions, however, limit the sensitivity to approximately 0.5 mb for enhancements in these channels. (Auth.)

  14. Genetic HLA Associations in Complex Regional Pain Syndrome With and Without Dystonia

    NARCIS (Netherlands)

    van Rooijen, D.E.; Roelen, D.L.; Verduijn, W.; Haasnoot, G.W.; Huygen, F.J.P.M.; Perez, R.S.G.M.; Claas, F.H.J.; Marinus, J.; van Hilten, J.J.; van den Maagdenberg, A.M.J.M.

    2012-01-01

    We previously showed evidence for a genetic association of the human leukocyte antigen (HLA) system and complex regional pain syndrome (CRPS) with dystonia. Involvement of the HLA system suggests that CRPS has a genetic component with perturbed regulation of inflammation and neuroplasticity as

  15. Reduced Position Effect in Mature Transgenic Plants Conferred by the Chicken Lysozyme Matrix-Associated Region

    NARCIS (Netherlands)

    Mlynárová, Ľudmila; Loonen, Annelies; Heldens, Jos; Jansen, Ritsert C.; Keizer, Paul; Stiekema, Willem J.; Nap, Jan-Peter

    1994-01-01

    Matrix-associated regions may be useful for studying the role of chromatin architecture in transgene activity of transformed plants. The chicken lysozyme A element was shown to have specific affinity for tobacco nuclear matrices, and its influence on the variability of transgene expression in

  16. Association of the polymorphism in the 5' flanking region of the ovine ...

    African Journals Online (AJOL)

    The insulin-like growth factor 1 (IGF-I) gene has been described in several studies as a candidate gene for growth traits in farm animals. The present preliminary study attempts to establish associations between growth traits and genetic polymorphisms at the 5' flanking region s IGF-I in the Baluchi sheep. The DNA of 102 ...

  17. Transient behavior of a flare-associated solar wind. I - Gas dynamics in a radial open field region

    Science.gov (United States)

    Nagai, F.

    1984-01-01

    A numerical investigation is conducted into the way in which a solar wind model initially satisfying both steady state and energy balance conditions is disturbed and deformed, under the assumption of heating that correspoonds to the energy release of solar flares of an importance value of approximately 1 which occur in radial open field regions. Flare-associated solar wind transient behavior is modeled for 1-8 solar radii. The coronal temperature around the heat source region rises, and a large thermal conductive flux flows inward to the chromosphere and outward to interplanetary space along field lines. The speed of the front of expanding chromospheric material generated by the impingement of the conduction front on the upper chromosphere exceeds the local sound velocity in a few minutes and eventually exceeds 100 million cm/sec.

  18. Cereal Crops Are not Created Equal: Wheat Consumption Associated with Obesity Prevalence Globally and Regionally

    Directory of Open Access Journals (Sweden)

    Wenpeng You

    2016-05-01

    Full Text Available Background: Cereals have been extensively advocated as the beneficial food group in terms of body weight management, but each staple cereal crop may contribute in different ways. Studies of the association between wheat availability and risk of obesity are controversial. This study aimed to test the global and regional association between wheat availability as reported by FAO and obesity prevalence at a population level. FAO does not distinguish between whole grain wheat and refined wheat. Methods: Population-specific data from 170 countries on prevalence of obesity, availabilities of mixed cereals, wheat, rice, maize, meat, sugar, fat, soy and calories and GDP are obtained from the UN agencies. All variables were measured as per capita per day (or per year. Each country is treated as an individual subject. SPSS v. 22 is used to analyse these data for all the 170 countries and official country groupings (regions using non parametric and parametric correlations, including partial correlation analysis. Results: Pearson’s correlation coefficient analysis showed that obesity prevalence is positively associated with wheat availability (r = 0.500, p < 0.001, but is inversely associated with availabilities of total cereals (r = -0.132, p = 0.087, rice (r = -0.405, p < 0.001 and maize (r = -0.227, p = 0.004. These associations remain in partial correlation model when we keep availabilities of meat, fat, sugar, soy, caloric intake and GDP statistically constant. Overall, positive associations between wheat availability and obesity prevalence remain in different regions. Maize and mixed cereal availabilities do not show independent associations with the obesity prevalence. Conclusions: Our study suggests that wheat availability is an independent predictor of the obesity prevalence both worldwide and with special regard to the regions of Africa, Americas and Asia. Future studies should distinguish between possible influence of whole grain and ultra

  19. Endotoxin predictors and associated respiratory outcomes differ with climate regions in the U.S.

    Science.gov (United States)

    Mendy, Angelico; Wilkerson, Jesse; Salo, Pӓivi M; Cohn, Richard D; Zeldin, Darryl C; Thorne, Peter S

    2018-03-01

    Although endotoxin is a recognized cause of environmental lung disease, how its relationship with respiratory outcomes varies with climate is unknown. To examine the endotoxin predictors as well as endotoxin association with asthma, wheeze, and sensitization to inhalant allergens in various US climate regions. We analyzed data on 6963 participants in the National Health and Nutrition Examination Survey. Endotoxin measurements of house dust from bedroom floor and bedding were performed at the University of Iowa. Linear and logistic regression analyses were used to identify endotoxin predictors and assess endotoxin association with health outcomes. The overall median house dust endotoxin was 16.2 EU/mg; it was higher in mixed-dry/hot-dry regions (19.7 EU/mg) and lower in mixed-humid/marine areas (14.8 EU/mg). Endotoxin predictors and endotoxin association with health outcomes significantly differed across climate regions. In subarctic/very cold/cold regions, log 10 -endotoxin was significantly associated with higher prevalence of wheeze outcomes (OR:1.48, 95% CI:1.19-1.85 for any wheeze, OR:1.48, 95% CI:1.22-1.80 for exercise-induced wheeze, OR:1.50, 95% CI:1.13-1.98 for prescription medication for wheeze, and OR:1.95, 95% CI:1.50-2.54 for doctor/ER visit for wheeze). In hot-humid regions, log 10 -endotoxin was positively associated with any wheeze (OR:1.66, 95% CI:1.04-2.65) and current asthma (OR:1.56, 95% CI:1.11-2.18), but negatively with sensitization to any inhalant allergens (OR:0.83, 95% CI:0.74-0.92). Endotoxin predictors and endotoxin association with asthma and wheeze differ across U.S. climate regions. Endotoxin is associated positively with wheeze or asthma in cold and hot-humid regions, but negatively with sensitization to inhalant allergens in hot-humid climates. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Characterization and genesis of waterfalls of the Presidente Figueiredo region, Northeast State of Amazonas, Brazil

    Directory of Open Access Journals (Sweden)

    AFONSO C. R. NOGUEIRA

    2001-06-01

    Full Text Available The waterfalls of the Presidente Figueiredo municipality represent a fascinating natural scenery of northeast state of Amazonas, northern Brazil. The falls, generally less than 10m high, are developed on siliciclastic rocks of the Nhamundá (Lower Silurian, and Manacapuru (Upper Silurian - Lower Devonian formations. Morphological and structural analyses of these features indicate that most of them originated through Quaternary neotectonics and are installed in NE-trending normal fault escarpments. Waterfalls also developed within pseudokarstic features, but are less frequent. The origin of the Presidente Figueiredo waterfalls probably goes back to the Neogene, when the region was submitted to laterization processes associated with a humid climate and a dense rainforest. These conditions favored the development of caves in quartzarenites of the Nhamundá Formation. During the Quaternary, the region was subjected to NE-trending normal faulting which displaced laterite layers, rivers and streams giving rise to waterfalls. These climatic and tectonic phenomena promoted intense relief dissection, as indicated by fault escarpment retreat and cave dismantlement, responsible for the present-day morphologic configuration.As cachoeiras da região de Presidente Figueiredo constituem um dos mais fascinantes cenários naturais do nordeste do Estado do Amazonas, norte do Brasil. As quedas, geralmente com menos de 10m de altura, são desenvolvidas em rochas siliciclásticas das formações Nhamundá (Siluriano inferior e Manacapuru (Siluriano superior-Devoniano inferior. Os estudos morfológico e estrutural dessas feições indicam que a maioria dessas quedas de água originaram-se por neotectônica quaternária e encontram-se instaladas em escarpas de falhas normais NE-SW. Ocorrem, ainda, com menor freqüência, cachoeiras evoluídas a partir de feições pseudocársticas. A origem das cachoeiras de Presidente Figueiredo provavelmente remonta ao Ne

  1. Production of Stone Spades and Emergence of the First State in the Yiluo region, China

    Directory of Open Access Journals (Sweden)

    Li Liu

    2009-09-01

    Full Text Available social changes during the Bronze Age (c. 2000-200 BC. This is a heartland of Chinese civilisation, as the earliest state emerged at the Erlitou site (c. 1900-1500 BC in the centre of the Yiluo basin. Our Yiluo archaeology project, initiated in 1997, is a long-term internationally collaborative and interdisciplinary programme, which holds a key position in the quest for the origins of early states in China. We have employed a number of methods and approaches to investigate many aspects relating to social change in the region. The full-coverage regional survey has helped us to reveal settlement patterns, and identify important regional centres, some of which were craft production sites. Spades were utilitarian in function and may have been primarily used by commoners for agricultural or other purposes. However, the sources of raw material were not widely available to every village, and some communities/social groups may have taken advantage of their settlement locations to control access to the raw material. Based on our research, production of stone tools most likely operated on a household basis, and the products were not only meant to fulfil the subsistence needs of makers and their neighbours, but also helped some individuals to gain higher social status and wealth through trade. The fact that dolomite spades found their way up to 100km away from their place of manufacture indicates the existence of region-wide trade networks in the Erlitou hinterland. Through these networks, not only utilitarian items but also elite goods (e.g., white pottery drinking vessels, were circulated, suggesting that lesser elite and commoners in the Erlitou hinterland created their own opportunities in the competition for power, prestige and wealth. From this perspective, the social formation of early states in China was not only hierarchical (Liu and Chen 2003, but heterarchical at a regional level. Stonemasons at Huizui were most likely independent craftsmen, whom

  2. The sensitivity of a water distribution system to regional state parameter variations

    CSIR Research Space (South Africa)

    Page, Philip R

    2018-05-01

    Full Text Available ]. The following types of parameters fall in each category: Proportional Change Parameters 𝑋𝑖. (i) Pipe lengths 𝐿 (ii) Pipe diameters𝐷 (iii) Pipe roughness coefficients 𝐶 (Hazen-Williams), 𝑁 (Chezy-Manning) or for Darcy-Weisbach (iv) Minor loss coefficients... for the case where there is a single state parameter region. 5. Pipe Parameter Scaling Laws Assume that the major friction loss in a pipe is described by either the Hazen-Williams (H-W) or Chezy-Manning (C-M) formulae (defined in the Appendix), with 𝐶 and𝑁...

  3. An Overlook to Low-Lying 2+ States of Rare Earth Region Nuclei With QRPA Approach

    International Nuclear Information System (INIS)

    Ganioglu, E.

    2008-01-01

    As much as known about the nuclear wave function, as much as known about the nuclear structure. Beyond the mean field to get a better wave function it is a way to introduce correlations on top of the mean field solution by means of random phase approximation. Since QRPA is a useful tool for the collective excitations in this study we studied the first 2 + states by means of QRPA and we examine the limits of QRPA description of nuclear excitation in the rare earth region

  4. Anuran amphibians of the urban region of Altamira (Oriental Amazonia, state of Pará, Brazil.

    Directory of Open Access Journals (Sweden)

    Flávio Bezerra Barros

    2009-06-01

    Full Text Available The present study aimed to take stock of the species of anurans in three localities of the urban region of Altamira, a municipal district in the west of the state of Pará (Oriental Amazonia. Collections were made between January and June of 2004. Fifteen species were recorded during the study. The family Hylidae was the most represented, with eight species. The data was compatible with the degree of conservation of the collection areas. The necessity of making new fauna inventories in all Brazilian biomes is of extreme urgency, particularly in the Amazon, given its vast extension and lack of inventories.

  5. Present state of the perception gap of nuclear energy between Japanese nuclear energy supplying region and an energy consuming region

    International Nuclear Information System (INIS)

    Ohnishi, Teruaki

    2002-01-01

    Public opinion surveys have been carried out since 1998 on what phase and on what extent of the perception of nuclear energy differs between Japanese dwelling in energy supplying region and an energy-consuming region. Southern Fukui rural district where 15 nuclear reactors are now installed and Osaka urban region of about 100 km apart from Fukui were selected as the respective targets for the energy supplying and consuming regions. Analyses of the data of about 3000 samples have revealed the followings. (1) The public in the nuclear energy supplying region are very friendly to nuclear energy so that only about 20 and 39 of the public are resistive to the general promotion of nuclear energy in Japan and to the construction of another nuclear reactor in their dwelling region, respectively. (2) On the other hand, in the energy-consuming region those respective fractions are 41 and 70 implying strong resistance to nuclear energy in the urban region. (3) Both the degree of interest in and the degree of knowledge on nuclear energy are very low, whereas the extent of fear to nuclear is high for the urban public. (4) Not only the fraction of the public who are satisfied with their present life, but the public fraction who is eagerly support the thought of return-to-nature are very high in the urban region. (5) On the other hand, in the energy supplying region, many peoples eagerly want their life to become more convenient than it is now, and 6) all those trends (I)-(5) are revealed more pronouncedly in the woman than the man. The perception gap of nuclear energy thus became clear between Japanese dwelling in rural and urban regions. On the basis of this knowledge, discussions on the nature of the so-called NIMBY will be made from the socio-psychological viewpoint and propositions will also be made on the methods to dissolve the perception gap of that soft. (author)

  6. Probing the transition state region in catalytic CO oxidation on Ru

    Energy Technology Data Exchange (ETDEWEB)

    Ostrom, H. [Stockholm Univ. (Sweden); Oberg, H. [Stockholm Univ. (Sweden); Xin, H. [SLAC National Accelerator Lab., Menlo Park, CA (United States); LaRue, J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Stanford Univ., Stanford, CA (United States); Beye, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Helmholtz Zentrum Berlin fur Materialien und Energie GmbH, Berlin (Germany); Dell' Angela, M. [Univ. of Hamburg and Center for Free Electron Laser Science, Hamburg (Germany); Gladh, J. [Stockholm Univ. (Sweden); Ng, M. L. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Sellberg, J. A. [Stockholm Univ. (Sweden); SLAC National Accelerator Lab., Menlo Park, CA (United States); Kaya, S. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Mercurio, G. [Univ. of Hamburg and Center for Free Electron Laser Science, Hamburg (Germany); Nordlund, D. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hantschmann, M. [Helmholtz Zentrum Berlin fur Materialien und Energie GmbH, Berlin (Germany); Hieke, F. [Univ. of Hamburg and Center for Free Electron Laser Science, Hamburg (Germany); Kuhn, D. [Helmholtz Zentrum Berlin fur Materialien und Energie GmbH, Berlin (Germany); Schlotter, W. F. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Dakovski, G. L. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Turner, J. J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Minitti, M. P. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Mitra, A. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Moeller, S. P. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Fohlisch, A. [Helmholtz Zentrum Berlin fur Materialien und Energie GmbH, Berlin (Germany); Univ. Potsdam, Potsdam (Germany); Wolf, M. [Fritz-Haber Institute of the Max-Planck-Society, Berlin (Germany); Wurth, W. [Univ. of Hamburg and Center for Free Electron Laser Science, Hamburg (Germany); DESY Photon Science, Hamburg (Germany); Persson, M. [The Univ. of Liverpool, Liverpool (United Kingdom); Norskov, J. K. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Stanford Univ., Stanford, CA (United States); Abild-Pedersen, F. [Stanford Univ., Stanford, CA (United States); Ogasawara, H. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Pettersson, L. G. M. [Stockholm Univ. (Sweden); Nilsson, A. [Stockholm Univ. (Sweden); SLAC National Accelerator Lab., Menlo Park, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-02-12

    Femtosecond x-ray laser pulses are used to probe the CO oxidation reaction on ruthenium (Ru) initiated by an optical laser pulse. On a time scale of a few hundred femtoseconds, the optical laser pulse excites motions of CO and O on the surface, allowing the reactants to collide, and, with a transient close to a picosecond (ps), new electronic states appear in the O K-edge x-ray absorption spectrum. Density functional theory calculations indicate that these result from changes in the adsorption site and bond formation between CO and O with a distribution of OC–O bond lengths close to the transition state (TS). After 1 ps, 10% of the CO populate the TS region, which is consistent with predictions based on a quantum oscillator model.

  7. Imputation-based analysis of association studies: candidate regions and quantitative traits.

    Directory of Open Access Journals (Sweden)

    Bertrand Servin

    2007-07-01

    Full Text Available We introduce a new framework for the analysis of association studies, designed to allow untyped variants to be more effectively and directly tested for association with a phenotype. The idea is to combine knowledge on patterns of correlation among SNPs (e.g., from the International HapMap project or resequencing data in a candidate region of interest with genotype data at tag SNPs collected on a phenotyped study sample, to estimate ("impute" unmeasured genotypes, and then assess association between the phenotype and these estimated genotypes. Compared with standard single-SNP tests, this approach results in increased power to detect association, even in cases in which the causal variant is typed, with the greatest gain occurring when multiple causal variants are present. It also provides more interpretable explanations for observed associations, including assessing, for each SNP, the strength of the evidence that it (rather than another correlated SNP is causal. Although we focus on association studies with quantitative phenotype and a relatively restricted region (e.g., a candidate gene, the framework is applicable and computationally practical for whole genome association studies. Methods described here are implemented in a software package, Bim-Bam, available from the Stephens Lab website http://stephenslab.uchicago.edu/software.html.

  8. Regional severe particle pollution and its association with synoptic weather patterns in the Yangtze River Delta region, China

    Science.gov (United States)

    Shu, Lei; Xie, Min; Gao, Da; Wang, Tijian; Fang, Dexian; Liu, Qian; Huang, Anning; Peng, Liwen

    2017-11-01

    Regional air pollution is significantly associated with dominant weather systems. In this study, the relationship between the particle pollution over the Yangtze River Delta (YRD) region and weather patterns is investigated. First, the pollution characteristics of particles in the YRD are studied using in situ monitoring data (PM2.5 and PM10) in 16 cities and Terra/MODIS AOD (aerosol optical depth) products collected from December 2013 to November 2014. The results show that the regional mean value of AOD is high in the YRD, with an annual mean value of 0.71±0.57. The annual mean particle concentrations in the cities of Jiangsu Province all exceed the national air quality standard. The pollution level is higher in inland areas, and the highest concentrations of PM2.5 and PM10 are 79 and 130 µg m-3, respectively, in Nanjing. The PM2.5 : PM10 ratios are typically high, thus indicating that PM2.5 is the overwhelmingly dominant particle pollutant in the YRD. The wintertime peak of particle concentrations is tightly linked to the increased emissions during the heating season as well as adverse meteorological conditions. Second, based on NCEP (National Center for Environmental Prediction) reanalysis data, synoptic weather classification is conducted and five typical synoptic patterns are objectively identified. Finally, the synthetic analysis of meteorological fields and backward trajectories are applied to further clarify how these patterns impact particle concentrations. It is demonstrated that air pollution is more or less influenced by high-pressure systems. The relative position of the YRD to the anti-cyclonic circulation exerts significant effects on the air quality of the YRD. The YRD is largely influenced by polluted air masses from the northern and the southern inland areas when it is located at the rear of the East Asian major trough. The significant downward motion of air masses results in stable weather conditions, thereby hindering the diffusion of air

  9. SECURITY RISKS, MYTHS IN A TRANSITIONING SUB-NATIONAL REGIONAL ECONOMY (CROSS RIVER STATE AND IMAGINATIVE GEOGRAPHIES OF NIGERIA

    Directory of Open Access Journals (Sweden)

    J. K. UKWAYI

    2015-03-01

    Full Text Available The emergence of an “international community” through accumulation of perceived risks that contrasts with those risks (of considerably lower levels of seriousness compared to those perceived constitutes one of the interesting (or intriguing subjects of risks and disaster studies surrounding the 9/11 era. The constructions of “imaginative geographies”, have frequently been biased in the practices that underlie the mapping of the foreign places tend to put-down the affected regions in their “paintings” for the global community. The latter are subsequently “demonized” in their ratings of competence for participating in world trade, tourism, travel, among other social/cultural, and economic and political activities. The objective of this article is to highlight how the exaggeration of risks (contrasted to actually existing/lived risks, practices that are frequently associated with such adverse “imaginative geographies” poses sub-national regional development dilemma in Nigeria’s Niger Delta. We trace the roots of adverse “imaginative geographies” of Nigeria to the Abacha dictatorship (1993-1997. Then we highlight the mixed characteristics of the Niger Delta conditions during the “return of positive image recapture” by Nigeria’s federal government (re-democratisation of the Fourth Republic, 1999-present, re-branding campaigns; as well as adverse conditions present. Most significantly, we show that despite these adversities, a combination of favorable geographical size, differentiation, sub-national regional security programme formulation and management taking aims at diversification have created “large oases” of peace and security in Cross River State, a part of the Niger Delta that has been completely unscathed by insurgencies of the nearby sub-national region and further away national origin. Apart from identifying sub-national regions qualifying for delisting from “adverse imaginative geographies” due to

  10. Cloud-radiation-precipitation associations over the Asian monsoon region: an observational analysis

    Science.gov (United States)

    Li, Jiandong; Wang, Wei-Chyung; Dong, Xiquan; Mao, Jiangyu

    2017-11-01

    This study uses 2001-2014 satellite observations and reanalyses to investigate the seasonal characteristics of Cloud Radiative Effects (CREs) and their associations with cloud fraction (CF) and precipitation over the Asian monsoon region (AMR) covering Eastern China (EC) and South Asia (SA). The CREs exhibit strong seasonal variations but show distinctly different relationships with CFs and precipitation over the two regions. For EC, the CREs is dominated by shortwave (SW) cooling, with an annual mean value of - 40 W m- 2 for net CRE, and peak in summer while the presence of extensive and opaque low-level clouds contributes to large Top-Of-Atmosphere (TOA) albedo (>0.5) in winter. For SA, a weak net CRE exists throughout the year due to in-phase compensation of SWCRE by longwave (LW) CRE associated with the frequent occurrence of high clouds. For the entire AMR, SWCRE strongly correlates with the dominant types of CFs, although the cloud vertical structure plays important role particularly in summer. The relationships between CREs and precipitation are stronger in SA than in EC, indicating the dominant effect of monsoon circulation in the former region. SWCRE over EC is only partly related to precipitation and shows distinctive regional variations. Further studies need to pay more attention to vertical distributions of cloud micro- and macro-physical properties, and associated precipitation systems over the AMR.

  11. Identification of genomic regions associated with female fertility in Danish Jersey using whole genome sequence data

    DEFF Research Database (Denmark)

    Höglund, Johanna; Guldbrandtsen, Bernt; Lund, Mogens Sandø

    2015-01-01

    6 QTL were detected for FTI: one QTL on each of BTA7, BTA20, BTA23, BTA25, and two QTL on BTA9 (QTL9–1 and QTL9–2). In the second step, ICF showed association with the QTL regions on BTA7, QTL9–2 QTL2 on BTA9, and BTA25, AIS for cows on BTA20 and BTA23, AIS for heifers on QTL9–2 on BTA9, IFL...... for cows on BTA20, BTA23 and BTA25, IFL for heifers on BTA7 and QTL9-2 on BTA9, NRR for heifers on BTA7 and BTA23, and NRR for cows on BTA23. Conclusion: The genome wide association study presented here revealed 6 genomic regions associated with FTI. Screening these 6 QTL regions for the underlying female...... quantitative trait locus regions were re-analyzed using a linear mixed model (animal model) for both FTI and its component traits AIS, NRR, IFL and ICF. The underlying traits were analyzed separately for heifers (first parity cows) and cows (later parity cows) for AIS, NRR, and IFL. Results: In the first step...

  12. HIV AND HCV COINFECTION: PREVALENCE, ASSOCIATED FACTORS AND GENOTYPE CHARACTERIZATION IN THE MIDWEST REGION OF BRAZIL

    Directory of Open Access Journals (Sweden)

    Solange Zacalusni Freitas

    2014-12-01

    Full Text Available A cross-sectional study on prevalence, associated factors and genotype distribution of HCV infection was conducted among 848 HIV-infected patients recruited at reference centers in the Midwest Region of Brazil. The prevalence rate of HIV-HCV coinfection was 6.9% (95% CI: 5.2 to 8.6. In multivariable analysis, increasing age, use of illicit drugs (injection and non-injection, a history of blood transfusion before 1994, and the absence of a steady partnership were significant independent associated factors for HIV-HCV coinfection. The phylogenetic analysis based on the NS5B region revealed the presence of two major circulating genotypes of HCV: genotypes 1 (58.3% and 3 (41.7%. The prevalence of HIV-HCV coinfection was lower than those reported in studies conducted with HIV-infected patients in different regions of Brazil, due to the fact that illicit drug use is not a frequent mode of HIV transmission in this region of Brazil. Serologic screening of HIV-patients for HCV before initiating antiretroviral treatment, a comprehensive identification of associated factors, and the implementation of effective harm reduction programs are highly recommended to provide useful information for treatment and to prevent HCV coinfection in these patients.

  13. HIV and HCV coinfection: prevalence, associated factors and genotype characterization in the Midwest Region of Brazil.

    Science.gov (United States)

    Freitas, Solange Zacalusni; Teles, Sheila Araújo; Lorenzo, Paulo Cesar; Puga, Marco Antonio Moreira; Tanaka, Tayana Serpa Ortiz; Thomaz, Danilo Yamamoto; Martins, Regina Maria Bringel; Druzian, Angelita Fernandes; Lindenberg, Andréa Siqueira Campos; Torres, Marina Sawada; Pereira, Sérgio A; Villar, Livia Melo; Lampe, Elisabete; Motta-Castro, Ana Rita Coimbra

    2014-01-01

    A cross-sectional study on prevalence, associated factors and genotype distribution of HCV infection was conducted among 848 HIV-infected patients recruited at reference centers in the Midwest Region of Brazil. The prevalence rate of HIV-HCV coinfection was 6.9% (95% CI: 5.2 to 8.6). In multivariable analysis, increasing age, use of illicit drugs (injection and non-injection), a history of blood transfusion before 1994, and the absence of a steady partnership were significant independent associated factors for HIV-HCV coinfection. The phylogenetic analysis based on the NS5B region revealed the presence of two major circulating genotypes of HCV: genotypes 1 (58.3%) and 3 (41.7%). The prevalence of HIV-HCV coinfection was lower than those reported in studies conducted with HIV-infected patients in different regions of Brazil, due to the fact that illicit drug use is not a frequent mode of HIV transmission in this region of Brazil. Serologic screening of HIV-patients for HCV before initiating antiretroviral treatment, a comprehensive identification of associated factors, and the implementation of effective harm reduction programs are highly recommended to provide useful information for treatment and to prevent HCV coinfection in these patients.

  14. Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.

    Directory of Open Access Journals (Sweden)

    Richard eMiles

    2014-01-01

    Full Text Available In the CA3 region of the hippocampus, pyramidal cells excite other pyramidal cells and interneurons. The axons of CA3 pyramidal cells spread throughout most of the region to form an associative network. These connections were first drawn by Cajal and Lorente de No. Their physiological properties were explored to understand epileptiform discharges generated in the region. Synapses between pairs of pyramidal cells involve one or few release sites and are weaker than connections made by mossy fibres on CA3 pyramidal cells. Synapses with interneurons are rather effective, as needed to control unchecked excitation. We examine contributions of recurrent synapses to epileptiform synchrony, to the genesis of sharp waves in the CA3 region and to population oscillations at theta and gamma frequencies. Recurrent connections in CA3, as other associative cortices, have a lower connectivity spread over a larger area than in primary sensory cortices. This sparse, but wide-ranging connectivity serves the functions of an associative network, including acquisition of neuronal representations as activity in groups of CA3 cells and completion involving the recall from partial cues of these ensemble firing patterns.

  15. Multiphase region of helimagnetic superlattices at low temperature in an extended six-state clock model

    Science.gov (United States)

    Lovelady, D. C.; Harper, H. M.; Brodsky, I. E.; Rabson, D. A.

    2006-05-01

    The variety of magnetic phases observed in rare-earth heterostructures at low temperatures (Jehan et al 1993 Phys. Rev. B 48 5594-606), such as Ho/Y, may be elucidated by an ANNNI-like model Hamiltonian. In previous work modelling bulk Ho (Seno, Rabson and Yeomans 1993 J. Phys. A: Math. Gen. 26 4887-905), such a Hamiltonian with a one-dimensional parameter space produced a single multiphase point. In contrast, the parameter space of the heterostructure model is three dimensional, and instead of an isolated multiphase point, we find two-dimensional multiphase regions. In an example of Villain's 'order from disorder' (Villain, Bidaux, Carton and Conte 1980 J. Physique 41 1263-72 Pimpinelli, Uimin and Villain 1991 J. Phys.: Condens. Matter 3 4693-719), an infinitesimal temperature breaks the ground-state degeneracy. In first order of a low-temperature expansion, we find that the degeneracy is broken everywhere in a multiphase region except on a line. A segment of the line appears to remain multiphase to all orders in a low-temperature expansion when the number L of magnetic layers between non-magnetic spacers is 4 but not for other values of L. For L = 4, the hierarchy of phases more closely resembles that in the ANNNI model than in the bulk six-state clock model on which the present model is based.

  16. Multiphase region of helimagnetic superlattices at low temperature in an extended six-state clock model

    International Nuclear Information System (INIS)

    Lovelady, D C; Harper, H M; Brodsky, I E; Rabson, D A

    2006-01-01

    The variety of magnetic phases observed in rare-earth heterostructures at low temperatures (Jehan et al 1993 Phys. Rev. B 48 5594-606), such as Ho/Y, may be elucidated by an ANNNI-like model Hamiltonian. In previous work modelling bulk Ho (Seno, Rabson and Yeomans 1993 J. Phys. A: Math. Gen. 26 4887-905), such a Hamiltonian with a one-dimensional parameter space produced a single multiphase point. In contrast, the parameter space of the heterostructure model is three dimensional, and instead of an isolated multiphase point, we find two-dimensional multiphase regions. In an example of Villain's 'order from disorder' (Villain, Bidaux, Carton and Conte 1980 J. Physique 41 1263-72; Pimpinelli, Uimin and Villain 1991 J. Phys.: Condens. Matter 3 4693-719), an infinitesimal temperature breaks the ground-state degeneracy. In first order of a low-temperature expansion, we find that the degeneracy is broken everywhere in a multiphase region except on a line. A segment of the line appears to remain multiphase to all orders in a low-temperature expansion when the number L of magnetic layers between non-magnetic spacers is 4 but not for other values of L. For L = 4, the hierarchy of phases more closely resembles that in the ANNNI model than in the bulk six-state clock model on which the present model is based

  17. Advantage of using allele-specific copy numbers when testing for association in regions with common copy number variants.

    Directory of Open Access Journals (Sweden)

    Gaëlle Marenne

    Full Text Available Copy number variants (CNV can be called from SNP-arrays; however, few studies have attempted to combine both CNV and SNP calls to test for association with complex diseases. Even when SNPs are located within CNVs, two separate association analyses are necessary, to compare the distribution of bi-allelic genotypes in cases and controls (referred to as SNP-only strategy and the number of copies of a region (referred to as CNV-only strategy. However, when disease susceptibility is actually associated with allele specific copy-number states, the two strategies may not yield comparable results, raising a series of questions about the optimal analytical approach. We performed simulations of the performance of association testing under different scenarios that varied genotype frequencies and inheritance models. We show that the SNP-only strategy lacks power under most scenarios when the SNP is located within a CNV; frequently it is excluded from analysis as it does not pass quality control metrics either because of an increased rate of missing calls or a departure from fitness for Hardy-Weinberg proportion. The CNV-only strategy also lacks power because the association testing depends on the allele which copy number varies. The combined strategy performs well in most of the scenarios. Hence, we advocate the use of this combined strategy when testing for association with SNPs located within CNVs.

  18. Atmospheric conditions associated with extreme fire activity in the Western Mediterranean region.

    Science.gov (United States)

    Amraoui, Malik; Pereira, Mário G; DaCamara, Carlos C; Calado, Teresa J

    2015-08-15

    Active fire information provided by TERRA and AQUA instruments on-board sun-synchronous polar MODIS platform is used to describe fire activity in the Western Mediterranean and to identify and characterize the synoptic patterns of several meteorological fields associated with the occurrence of extreme fire activity episodes (EEs). The spatial distribution of the fire pixels during the period of 2003-2012 leads to the identification of two most affected sub-regions, namely the Northern and Western parts of the Iberian Peninsula (NWIP) and Northern Africa (NAFR). The temporal distribution of the fire pixels in these two sub-regions is characterized by: (i) high and non-concurrent inter- and intra-annual variability with maximum values during the summer of 2003 and 2005 in NWIP and 2007 and 2012 in NAFR; and, (ii) high intra-annual variability dominated by a prominent annual cycle with a main peak centred in August in both sub-regions and a less pronounced secondary peak in March only evident in NWIP region. The 34 EEs identified were grouped according to the location, period of occurrence and spatial configuration of the associated synoptic patterns into 3 clusters (NWIP-summer, NWIP-winter and NAFR-summer). Results from the composite analysis reveal similar fire weather conditions (statistically significant positive anomalies of air temperature and negative anomalies of air relative humidity) but associated with different circulation patterns at lower and mid-levels of the atmosphere associated with the occurrence of EEs in each cluster of the Western Mediterranean region. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Associations among Wine Grape Microbiome, Metabolome, and Fermentation Behavior Suggest Microbial Contribution to Regional Wine Characteristics.

    Science.gov (United States)

    Bokulich, Nicholas A; Collins, Thomas S; Masarweh, Chad; Allen, Greg; Heymann, Hildegarde; Ebeler, Susan E; Mills, David A

    2016-06-14

    Regionally distinct wine characteristics (terroir) are an important aspect of wine production and consumer appreciation. Microbial activity is an integral part of wine production, and grape and wine microbiota present regionally defined patterns associated with vineyard and climatic conditions, but the degree to which these microbial patterns associate with the chemical composition of wine is unclear. Through a longitudinal survey of over 200 commercial wine fermentations, we demonstrate that both grape microbiota and wine metabolite profiles distinguish viticultural area designations and individual vineyards within Napa and Sonoma Counties, California. Associations among wine microbiota and fermentation characteristics suggest new links between microbiota, fermentation performance, and wine properties. The bacterial and fungal consortia of wine fermentations, composed from vineyard and winery sources, correlate with the chemical composition of the finished wines and predict metabolite abundances in finished wines using machine learning models. The use of postharvest microbiota as an early predictor of wine chemical composition is unprecedented and potentially poses a new paradigm for quality control of agricultural products. These findings add further evidence that microbial activity is associated with wine terroir Wine production is a multi-billion-dollar global industry for which microbial control and wine chemical composition are crucial aspects of quality. Terroir is an important feature of consumer appreciation and wine culture, but the many factors that contribute to terroir are nebulous. We show that grape and wine microbiota exhibit regional patterns that correlate with wine chemical composition, suggesting that the grape microbiome may influence terroir In addition to enriching our understanding of how growing region and wine properties interact, this may provide further economic incentive for agricultural and enological practices that maintain regional

  20. Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk

    Directory of Open Access Journals (Sweden)

    Spraker Terry R

    2010-11-01

    Full Text Available Abstract Background Chronic wasting disease (CWD is a transmissible spongiform encephalopathy (TSE of cervids including white-tailed (Odocoileus virginianus and mule deer (Odocoileus hemionus, Rocky Mountain elk (Cervus elaphus nelsoni, and moose (Alces alces. A leucine variant at position 132 (132L in prion protein of Rocky Mountain elk confers a long incubation time with CWD, but not complete resistance. However, variants in regulatory regions outside the open reading frame of PRNP have been associated with varying degrees of susceptibility to prion disease in other species, and some variants have been observed in similar regions of Rocky Mountain elk PRNP. Thus, additional genetic variants might provide increased protection, either alone or in combination with 132L. Findings This study provided genomic sequence of all exons for PRNP of Rocky Mountain elk. Many functional sites in and around the PRNP gene region were sequenced, and this report approximately doubled (to 75 the number of known variants in this region. A haplotype-tagging approach was used to reduce the number of genetic variants required to survey this variation in the PRNP gene region of 559 Rocky Mountain elk. Eight haplotypes were observed with frequencies over 1.0%, and one haplotype was present at 71.2% frequency, reflecting limited genetic diversity in the PRNP gene region. Conclusions The presence of 132L cut odds of CWD by more than half (Odds Ratio = 0.43; P = 0.0031, which was similar to a previous report. However after accounting for 132L, no association with CWD was found for any additional variants in the PRNP region (P > 0.05.

  1. Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.

    Directory of Open Access Journals (Sweden)

    Amaury Vaysse

    2011-10-01

    Full Text Available The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly spaced SNPs. We first identify 44 genomic regions exhibiting extreme differentiation across multiple breeds. Genetic variation in these regions correlates with variation in several phenotypic traits that vary between breeds, and we identify novel associations with both morphological and behavioral traits. We next scan the genome for signatures of selective sweeps in single breeds, characterized by long regions of reduced heterozygosity and fixation of extended haplotypes. These scans identify hundreds of regions, including 22 blocks of homozygosity longer than one megabase in certain breeds. Candidate selection loci are strongly enriched for developmental genes. We chose one highly differentiated region, associated with body size and ear morphology, and characterized it using high-throughput sequencing to provide a list of variants that may directly affect these traits. This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation. The many blocks of reduced haplotype diversity observed across the genome in dog breeds are the result of both selection and genetic drift, but extended blocks of homozygosity on a megabase scale appear to be best explained by selection. Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease.

  2. Specific Midgut Region Controlling the Symbiont Population in an Insect-Microbe Gut Symbiotic Association

    Science.gov (United States)

    Kim, Jiyeun Kate; Kim, Na Hyang; Jang, Ho Am; Kikuchi, Yoshitomo; Kim, Chan-Hee

    2013-01-01

    Many insects possess symbiotic bacteria that affect the biology of the host. The level of the symbiont population in the host is a pivotal factor that modulates the biological outcome of the symbiotic association. Hence, the symbiont population should be maintained at a proper level by the host's control mechanisms. Several mechanisms for controlling intracellular symbionts of insects have been reported, while mechanisms for controlling extracellular gut symbionts of insects are poorly understood. The bean bug Riptortus pedestris harbors a betaproteobacterial extracellular symbiont of the genus Burkholderia in the midgut symbiotic organ designated the M4 region. We found that the M4B region, which is directly connected to the M4 region, also harbors Burkholderia symbiont cells, but the symbionts therein are mostly dead. A series of experiments demonstrated that the M4B region exhibits antimicrobial activity, and the antimicrobial activity is specifically potent against the Burkholderia symbiont but not the cultured Burkholderia and other bacteria. The antimicrobial activity of the M4B region was detected in symbiotic host insects, reaching its highest point at the fifth instar, but not in aposymbiotic host insects, which suggests the possibility of symbiont-mediated induction of the antimicrobial activity. This antimicrobial activity was not associated with upregulation of antimicrobial peptides of the host. Based on these results, we propose that the M4B region is a specialized gut region of R. pedestris that plays a critical role in controlling the population of the Burkholderia gut symbiont. The molecular basis of the antimicrobial activity is of great interest and deserves future study. PMID:24038695

  3. Marshak Lectureship Talk: Women in Physics in the Baltic States Region: Problems and Solutions

    Science.gov (United States)

    Satkovskiene, Dalia

    2008-03-01

    In this contribution the gender equality problem in physics will be discussed on the basis of the results obtained implementing the project ``Baltic States Network: Women in Sciences and High Technology'' (BASNET) initiated by Lithuanian women physicists and financed by European Commission. The main goal of BASNET project was creation of the regional Strategy how to deal with women in sciences problem in the Baltic States. It has some stages and the contribution follows them. The first one was in depth sociological study aiming to find out disincentives and barriers women scientists face in their career and work at science and higher education institutions. Analysis of results revealed wide range of problems concerned with science organization, management and financing common for both counterparts. However it also proved the existence of women discrimination in sciences. As main factors influencing women under-representation in Physics was found: the stereotypes existing in the society where physics is assigned to the masculine area of activity; failings of the science management system, where highest positions are distributed not using the institutionalized objective criteria but by voting, where the correctness of majority solutions is anticipated implicitly. In physics where male scientists are the majority (they also usually compose executive boards, committees etc.) results of such a procedures often are unfavorable for women. The same reasons also influence women ``visibility'' in physicist's community and as the consequence possibility to receive needed recourses for their research as well as appropriate presentation of results obtained. The study revealed also the conservatism of scientific community- reluctance to face existing in the scientific society problems and to start solving them. On the basis of the results obtained as well practice of other countries the common strategy of solving women in physics (sciences) in the Baltic States region was

  4. Suicide in the Kurdistan Region of Iraq, state of the art.

    Science.gov (United States)

    Hanna, Vian Nissan; Ahmad, Abdulbaghi

    2009-01-01

    In recent years the, incidence of suicide in Kurdistan has been increasing, especially among females, to a degree it cannot be neglected. Consequently, attention was given to this phenomena and the aggressive method of suicide used by young peoples, especially females, in Kurdistan. In attempt to obtain an objective picture of the frequently media-reported suicide among youths and women in the Kurdistan Region of Iraq. The responsible authorities and medical service units in the region were visited to collect information, and the available data were explored to produce a state-of-the-art overview on the subject. Because of insufficient documentation and lack of systematic registration, the data on suicide were scattered and difficult to evaluate. However, the findings did confirm that suicide exists as a serious problem in the society in Kurdistan, particularly among females. Urgent attention is demanded from the responsible authorities and organizations concerned in the region. Further research is needed to investigate the exact extent of suicide and its correlates in the society in Kurdistan, in order to plan for effective preventive measures.

  5. Corrected and republished: Suicide in the Kurdistan Region of Iraq, state of the art.

    Science.gov (United States)

    Hanna, Vian Nissan; Ahmad, Abdulbaghi

    2013-04-01

    In recent years the, incidence of suicide in Kurdistan has been increasing, especially among females, to a degree it cannot be neglected. Consequently, attention was given to this phenomena and the aggressive method of suicide used by young peoples, especially females, in Kurdistan. In attempt to obtain an objective picture of the frequently media-reported suicide among youths and women in the Kurdistan Region of Iraq. The responsible authorities and medical service units in the region were visited to collect information, and the available data were explored to produce a state-of-the-art overview on the subject. Because of insufficient documentation and lack of systematic registration, the data on suicide were scattered and difficult to evaluate. However, the findings did confirm that suicide exists as a serious problem in the society in Kurdistan, particularly among females. Urgent attention is demanded from the responsible authorities and organizations concerned in the region. Further research is needed to investigate the exact extent of suicide and its correlates in the society in Kurdistan, in order to plan for effective preventive measures. Burn, Iraq, Kurdistan, Suicide, Young.

  6. Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state.

    Science.gov (United States)

    Ge, Hao; Wu, Pingping; Qian, Hong; Xie, Xiaoliang Sunney

    2018-03-01

    Within an isogenic population, even in the same extracellular environment, individual cells can exhibit various phenotypic states. The exact role of stochastic gene-state switching regulating the transition among these phenotypic states in a single cell is not fully understood, especially in the presence of positive feedback. Recent high-precision single-cell measurements showed that, at least in bacteria, switching in gene states is slow relative to the typical rates of active transcription and translation. Hence using the lac operon as an archetype, in such a region of operon-state switching, we present a fluctuating-rate model for this classical gene regulation module, incorporating the more realistic operon-state switching mechanism that was recently elucidated. We found that the positive feedback mechanism induces bistability (referred to as deterministic bistability), and that the parameter range for its occurrence is significantly broadened by stochastic operon-state switching. We further show that in the absence of positive feedback, operon-state switching must be extremely slow to trigger bistability by itself. However, in the presence of positive feedback, which stabilizes the induced state, the relatively slow operon-state switching kinetics within the physiological region are sufficient to stabilize the uninduced state, together generating a broadened parameter region of bistability (referred to as stochastic bistability). We illustrate the opposite phenotype-transition rate dependence upon the operon-state switching rates in the two types of bistability, with the aid of a recently proposed rate formula for fluctuating-rate models. The rate formula also predicts a maximal transition rate in the intermediate region of operon-state switching, which is validated by numerical simulations in our model. Overall, our findings suggest a biological function of transcriptional "variations" among genetically identical cells, for the emergence of bistability and

  7. Ten years with the CPA (Cubic-Plus-Association) equation of state. Part 2. Cross-associating and multicomponent systems

    DEFF Research Database (Denmark)

    Kontogeorgis, Georgios; Michelsen, Michael Locht; Folas, Georgios

    2006-01-01

    In this second article of the review on the applications of the CPA (Cubic-Plus-Association) equation of state, the focus is placed on cross-associating systems. Various such mixtures are investigated, including (i) systems with two self-associating compounds ( e. g., water-alcohol systems...

  8. Regional siting survey for thermal power plants in the state of Ohio

    International Nuclear Information System (INIS)

    Elkins, M.L.; DiNunno, J.J.

    1975-01-01

    The selection and evaluation of sites for power plants have become increasingly difficult in recent years as pressures from various societal segments have resulted in government restraints on selection and burning of fossil fuels, on methods of heat dissipation, on acquisition of transmission line rights-of-way, and on environmental impact in general. The key elements in successful application of power plant siting technology are the development of the proper balance among the basic siting considerations and the understanding that level of detail in a study varies in an inverse relationship with the siting area under examination. As the first step in the process of selection and eventual licensing of new thermal power plant sites for a utility in the State of Ohio, the entire state was screened to determine promising candidate regions large enough to offer several possible candidate sites for thermal power plants. Because of the size of the area under consideration and the advantages of developing sites with an ultimate capacity for more than one power plant, sites with an installed capacity of 1100 to 4400 MW(e) were considered for this study. As a result of the preliminary screening conducted in four distinct steps, three candidate regions showed the best overall promise for either nuclear or fossil-fueled power plant development. Tentative identification was made of candidate sites within these candidate regions, and follow-on studies conducted in an increasing level of detail are presently in progress to determine the candidate site(s) most promising for power plant siting. (U.S.)

  9. Genetic association of FTO/IRX region with obesity and overweight in the Polish population.

    Directory of Open Access Journals (Sweden)

    Marta Sobalska-Kwapis

    Full Text Available Genome-wide association studies (GWAS have identified many loci associated with body mass index (BMI in many different populations. Variants in the FTO locus are reported to be one of the strongest genetic predictors of obesity. Recent publications pointed also to a topologically associated domain (TAD which is identified as a novel region affecting BMI. The TAD area encompasses the IRXB cluster (IRX3, IRX5, IRX6, FTO and RPGRIP1L genes.In this study, we investigated the relationship between variation of the FTO and IRX genes and obesity in Poles. We presented a case-control association analysis (normal versus overweight and/or obesity group of Polish adult individuals (N = 5418. We determined whether or not the chromosomal region 16:53 500 000-55 500 000 contains polymorphic variants which are correlated with BMI in Polish population, including sex and age stratified analysis.The obtained results showed that the problem of weight-height abnormalities differently affects populations of Polish women and men (χ2 = 187.1; p0.98, r2>0.80. We confirmed presence of the genetic susceptibility loci located in intron 1 of the FTO gene, which were correlated with BMI in our study group. For the first time, our analyses revealed strong association of FTO intronic variants (block 8 with overweight in group of men only. We have also identified association of the IRX region with overweight and/or obesity in Polish individuals.Our study demonstrated how tested SNPs make differential contributions to obesity and overweight risk. We revealed sex dependent differences in the distribution of tested loci which are associated with BMI in the population of Poles.

  10. Regional gray matter density associated with emotional conflict resolution: evidence from voxel-based morphometry.

    Science.gov (United States)

    Deng, Z; Wei, D; Xue, S; Du, X; Hitchman, G; Qiu, J

    2014-09-05

    Successful emotion regulation is a fundamental prerequisite for well-being and dysregulation may lead to psychopathology. The ability to inhibit spontaneous emotions while behaving in accordance with desired goals is an important dimension of emotion regulation and can be measured using emotional conflict resolution tasks. Few studies have investigated the gray matter correlates underlying successful emotional conflict resolution at the whole-brain level. We had 190 adults complete an emotional conflict resolution task (face-word task) and examined the brain regions significantly correlated with successful emotional conflict resolution using voxel-based morphometry. We found successful emotional conflict resolution was associated with increased regional gray matter density in widely distributed brain regions. These regions included the dorsal anterior cingulate/dorsal medial prefrontal cortex, ventral medial prefrontal cortex, supplementary motor area, amygdala, ventral striatum, precuneus, posterior cingulate cortex, inferior parietal lobule, superior temporal gyrus and fusiform face area. Together, our results indicate that individual differences in emotional conflict resolution ability may be attributed to regional structural differences across widely distributed brain regions. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

  11. Response to state comments on the revised draft North Central Regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the North Central Region on the revised draft North Central Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft North Central RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to North Central State comments on both the revised draft North Central Regional Geologic Characterization Report (RGCR) and the revised draft North Central Regional Environmental Characterization Report (RECR)

  12. Response to state comments on the revised draft Southeastern Regional Characterization Reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the states of the Southeastern Region on the revised draft Southeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Southeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Southeastern State comments on both the revised draft Southeastern Regional Geologic Characterization Report (RGCR) and the revised draft Southeastern Regional Environmental Characterization Report (RECR)

  13. Response to state comments on the revised draft northeastern regional characterization reports for the Crystalline Repository Project

    International Nuclear Information System (INIS)

    1985-08-01

    The purpose of this document is to respond to the comments received from the States of the Northeastern Region on the revised draft Northeastern Regional Characterization Reports (RCRs). The responses in this document indicate the manner in which the suggestions or comments received have been considered in modifying the revised draft Northeastern RCRs. Both general comments related to the overall Crystalline Repository Project (CRP) and comments on specific sections of the RCRs are addressed. This document responds to Northeastern State comments on both the revised draft Northeastern Regional Geologic Characterization Report (RGCR) and the revised draft Northeastern Regional Environmental Characterization Report (RECR)

  14. Yellow fever in Pará State, Amazon region of Brazil, 1998-1999: entomologic and epidemiologic findings.

    Science.gov (United States)

    Vasconcelos, P F; Rosa, A P; Rodrigues, S G; Rosa, E S; Monteiro, H A; Cruz, A C; Barros, V L; Souza, M R; Rosa, J F

    2001-01-01

    Yellow fever (YF) is frequently associated with high severity and death rates in the Amazon region of Brazil. During the rainy seasons of 1998 and 1999, 23 (eight deaths) and 34 (eight deaths) human cases of YF were reported, respectively, in different geographic areas of Pará State; most cases were on Marajó Island. Patients were 1 to 46 years of age. Epidemiologic and ecological studies were conducted in Afuá and Breves on Marajó Island; captured insects yielded isolates of 4 and 11 YF strains, respectively, from Haemagogus janthinomys pooled mosquitoes. The cases on Marajó Island in 1999 resulted from lack of vaccination near the focus of the disease and intense migration, which brought many nonimmune people to areas where infected vectors were present. We hypothesize that YF virus remains in an area after an outbreak by vertical transmission among Haemagogus mosquitoes.

  15. Modelling Groundwater Depletion at Regional and Global Scales: Present State and Future Prospects.

    Science.gov (United States)

    Wada, Yoshihide

    2015-01-01

    Except for frozen water in ice and glaciers, groundwater is the world's largest distributed store of freshwater and has strategic importance to global food and water security. In this paper, the most recent advances quantifying groundwater depletion (GWD) are comprehensively reviewed. This paper critically evaluates the recently advanced modeling approaches estimating GWD at regional and global scales, and the evidence of feedbacks to the Earth system including sea-level rise associated with GWD. Finally, critical challenges and opportunities in the use of groundwater are identified for the adaption to growing food demand and uncertain climate.

  16. Clinical features and pathophysiology of Complex Regional Pain Syndrome – current state of the art

    Science.gov (United States)

    Marinus, Johan; Moseley, G. Lorimer; Birklein, Frank; Baron, Ralf; Maihöfner, Christian; Kingery, Wade S.; van Hilten, Jacobus J.

    2017-01-01

    That a minor injury can trigger a complex regional pain syndrome (CRPS) - multiple system dysfunction, severe and often chronic pain and disability - has fascinated scientists and perplexed clinicians for decades. However, substantial advances across several medical disciplines have recently increased our understanding of CRPS. Compelling evidence implicates biological pathways that underlie aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity in the clinical features of CRPS. Collectively, the evidence points to CRPS being a multifactorial disorder that is associated with an aberrant host response to tissue injury. Varying susceptibility to perturbed regulation of any of the underlying biological pathways probably accounts for the clinical heterogeneity of CRPS. PMID:21683929

  17. Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease.

    Science.gov (United States)

    Mullins, Roger J; Mustapic, Maja; Goetzl, Edward J; Kapogiannis, Dimitrios

    2017-04-01

    Brain insulin resistance (IR), which depends on insulin-receptor-substrate-1 (IRS-1) phosphorylation, is characteristic of Alzheimer's disease (AD). Previously, we demonstrated higher pSer312-IRS-1 (ineffective insulin signaling) and lower p-panTyr-IRS-1 (effective insulin signaling) in neural origin-enriched plasma exosomes of AD patients vs. Here, we hypothesized that these exosomal biomarkers associate with brain atrophy in AD. We studied 24 subjects with biomarker-supported probable AD (low CSF Aβ 42 ). Exosomes were isolated from plasma, enriched for neural origin using immunoprecipitation for L1CAM, and measured for pSer 312 - and p-panTyr-IRS-1 phosphotypes. MPRAGE images were segmented by brain tissue type and voxel-based morphometry (VBM) analysis for gray matter against pSer 312 - and p-panTyr-IRS-1 was conducted. Given the regionally variable brain expression of IRS-1, we used the Allen Brain Atlas to make spatial comparisons between VBM results and IRS-1 expression. Brain volume was positively associated with P-panTyr-IRS-1 and negatively associated with pSer 312 -IRS-1 in a strikingly similar regional pattern (bilateral parietal-occipital junction, R middle temporal gyrus). This volumetric association pattern was spatially correlated with Allen Human Brain atlas normal brain IRS-1 expression. Exosomal biomarkers of brain IR are thus associated with atrophy in AD as could be expected by their pathophysiological roles and do so in a pattern that reflects regional IRS-1 expression. Furthermore, neural-origin plasma exosomes may recover molecular signals from specific brain regions. Hum Brain Mapp 38:1933-1940, 2017. © 2017 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Experience with WASP and MAED among IAEA Member States participating in the Regional Co-operative Agreement (RCA) in Asia and the Pacific Region

    International Nuclear Information System (INIS)

    1989-10-01

    The report includes the proceedings and papers presented during the workshop on the experience with WASP/MAED computer programs among IAEA Member States participating in the regional co-operative agreement (RCA) in Asia and the Pacific Region, organized by the IAEA and held in Kuala Lumpur (Malaysia) between 5-9 December 1988. A separate abstract was prepared for each of the 14 papers presented. Refs, figs and tabs

  19. Models of regional habitat quality and connectivity for pumas (Puma concolor) in the southwestern United States.

    Science.gov (United States)

    Dickson, Brett G; Roemer, Gary W; McRae, Brad H; Rundall, Jill M

    2013-01-01

    The impact of landscape changes on the quality and connectivity of habitats for multiple wildlife species is of global conservation concern. In the southwestern United States, pumas (Puma concolor) are a well distributed and wide-ranging large carnivore that are sensitive to loss of habitat and to the disruption of pathways that connect their populations. We used an expert-based approach to define and derive variables hypothesized to influence the quality, location, and permeability of habitat for pumas within an area encompassing the entire states of Arizona and New Mexico. Survey results indicated that the presence of woodland and forest cover types, rugged terrain, and canyon bottom and ridgeline topography were expected to be important predictors of both high quality habitat and heightened permeability. As road density, distance to water, or human population density increased, the quality and permeability of habitats were predicted to decline. Using these results, we identified 67 high quality patches across the study area, and applied concepts from electronic circuit theory to estimate regional patterns of connectivity among these patches. Maps of current flow among individual pairs of patches highlighted possible pinch points along two major interstate highways. Current flow summed across all pairs of patches highlighted areas important for keeping the entire network connected, regardless of patch size. Cumulative current flow was highest in Arizona north of the Colorado River and around Grand Canyon National Park, and in the Sky Islands region owing to the many small habitat patches present. Our outputs present a first approximation of habitat quality and connectivity for dispersing pumas in the southwestern United States. Map results can be used to help target finer-scaled analyses in support of planning efforts concerned with the maintenance of puma metapopulation structure, as well as the protection of landscape features that facilitate the dispersal

  20. Models of regional habitat quality and connectivity for pumas (Puma concolor in the southwestern United States.

    Directory of Open Access Journals (Sweden)

    Brett G Dickson

    Full Text Available The impact of landscape changes on the quality and connectivity of habitats for multiple wildlife species is of global conservation concern. In the southwestern United States, pumas (Puma concolor are a well distributed and wide-ranging large carnivore that are sensitive to loss of habitat and to the disruption of pathways that connect their populations. We used an expert-based approach to define and derive variables hypothesized to influence the quality, location, and permeability of habitat for pumas within an area encompassing the entire states of Arizona and New Mexico. Survey results indicated that the presence of woodland and forest cover types, rugged terrain, and canyon bottom and ridgeline topography were expected to be important predictors of both high quality habitat and heightened permeability. As road density, distance to water, or human population density increased, the quality and permeability of habitats were predicted to decline. Using these results, we identified 67 high quality patches across the study area, and applied concepts from electronic circuit theory to estimate regional patterns of connectivity among these patches. Maps of current flow among individual pairs of patches highlighted possible pinch points along two major interstate highways. Current flow summed across all pairs of patches highlighted areas important for keeping the entire network connected, regardless of patch size. Cumulative current flow was highest in Arizona north of the Colorado River and around Grand Canyon National Park, and in the Sky Islands region owing to the many small habitat patches present. Our outputs present a first approximation of habitat quality and connectivity for dispersing pumas in the southwestern United States. Map results can be used to help target finer-scaled analyses in support of planning efforts concerned with the maintenance of puma metapopulation structure, as well as the protection of landscape features that facilitate

  1. STATE FARMS AND MTS OF MOSCOW REGION BEFORE AND AT THE BEGINNING OF THE GREAT PATRIOTIC WAR

    Directory of Open Access Journals (Sweden)

    Andrey Anatolyevich Androsov

    2015-02-01

    Full Text Available In the article on the basis of previously unknown archival materials for the first time in the national historiography a public way in Soviet agriculture of Moscow region in the period 1940-1942 yy. is considered. Particular attention is paid to the historiography of this problem, new methods of modern historians in the study of the rural economy of this period are marked. Different approaches in the analysis of the results of collectivization and the appearance in the USSR (Union of Soviet Socialist Republics new sectors of agricultural production - the state and the collective are compared. Features of the state agricultural production plants and the legal status of their workers in the state farms and machine and tractor stations (MTS are pointed. Specific difficulties encountered in the process and as a result of the evacuation of the property of state farms and MTS, preparing for spring sowing in the implementation of the directive of All-Union Communist Party of Bolsheviks of self-reliance are examined in details. The dedication of staff rear structures in the rescue of the property entrusted to them, the preparation of the spring sowing campaign, raising funds and manpower in extreme conditions is marked. Relationship of the status on the front and readiness of rear workers to work in the changed circumstances is traced. The difference between subjective difficulties associated with defects of command-administrative system, which prevailed in government and objective hardship arising from the outbreak of hostilities is taken into account. Much attention is paid to the description of the technical condition of the machine and tractor fleet of state farms and MTS as the main means of agricultural production. The conclusion about the causes and consequences of unavailability governance structures to conduct evacuation and preparation of the spring sowing are made.

  2. Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults

    Directory of Open Access Journals (Sweden)

    Elmira Ismaylova

    2018-05-01

    Full Text Available Numerous studies have shown differences in the functioning in the areas of the frontal-limbic circuitry between depressed patients and controls. However, current knowledge on frontal-limbic neural substrates of individual differences in mood states in everyday life in healthy individuals is scarce. The present study investigates anatomical, resting-state, and functional neural correlates of daily mood states in healthy individuals. We expected to observe associations between mood and the frontal-limbic circuitry and the default-mode network (DMN. A total of 42 healthy adults (19 men, 23 women; 34 ± 1.2 years regularly followed for behavior and psychosocial functioning since age of 6, underwent a functional magnetic resonance imaging scan, and completed a daily diary of mood states and related cognitions for 5 consecutive days. Results showed that individuals with smaller left hippocampal gray matter volumes experienced more negative mood and rumination in their daily life. Greater resting-state functional connectivity (rsFC within the DMN, namely between posterior cingulate cortex (PCC and medial prefrontal cortex regions as well as between PCC and precuneus, was associated with both greater negative and positive mood states in daily life. These rsFC results could be indicative of the role of the DMN regional functioning in emotional arousal, irrespective of valence. Lastly, greater daily positive mood was associated with greater activation in response to negative emotional stimuli in the precentral gyri, previously linked to emotional interference on cognitive control. Altogether, present findings might reflect neural mechanisms underlying daily affect and cognition among healthy individuals.

  3. Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults.

    Science.gov (United States)

    Ismaylova, Elmira; Di Sante, Jessica; Gouin, Jean-Philippe; Pomares, Florence B; Vitaro, Frank; Tremblay, Richard E; Booij, Linda

    2018-01-01

    Numerous studies have shown differences in the functioning in the areas of the frontal-limbic circuitry between depressed patients and controls. However, current knowledge on frontal-limbic neural substrates of individual differences in mood states in everyday life in healthy individuals is scarce. The present study investigates anatomical, resting-state, and functional neural correlates of daily mood states in healthy individuals. We expected to observe associations between mood and the frontal-limbic circuitry and the default-mode network (DMN). A total of 42 healthy adults (19 men, 23 women; 34 ± 1.2 years) regularly followed for behavior and psychosocial functioning since age of 6, underwent a functional magnetic resonance imaging scan, and completed a daily diary of mood states and related cognitions for 5 consecutive days. Results showed that individuals with smaller left hippocampal gray matter volumes experienced more negative mood and rumination in their daily life. Greater resting-state functional connectivity (rsFC) within the DMN, namely between posterior cingulate cortex (PCC) and medial prefrontal cortex regions as well as between PCC and precuneus, was associated with both greater negative and positive mood states in daily life. These rsFC results could be indicative of the role of the DMN regional functioning in emotional arousal, irrespective of valence. Lastly, greater daily positive mood was associated with greater activation in response to negative emotional stimuli in the precentral gyri, previously linked to emotional interference on cognitive control. Altogether, present findings might reflect neural mechanisms underlying daily affect and cognition among healthy individuals.

  4. Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

    Directory of Open Access Journals (Sweden)

    Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

    2014-09-01

    Full Text Available A unique characteristic of the Silkie chicken is its fibromelanosis phenotype. The dermal layer of its skin, its connective tissue and shank dermis are hyperpigmented. This dermal hyperpigmentation phenotype is controlled by the sex-linked inhibitor of dermal melanin gene (ID and the dominant fibromelanosis allele. This study attempted to confirm the genomic region associated with ID. By genotyping, ID was found to be closely linked to the region between GGA_rs16127903 and GGA_rs14685542 (8406919 bp on chromosome Z, which contains ten functional genes. The expression of these genes was characterized in the embryo and 4 days after hatching and it was concluded that MTAP, encoding methylthioadenosinephosphorylase, would be the most likely candidate gene. Finally, target DNA capture and sequence analysis was performed, but no specific SNP(s was found in the targeted region of the Silkie genome. Further work is necessary to identify the causal ID mutation located on chromosome Z.

  5. Regional gray matter volume is associated with trait modesty: Evidence from voxel-based morphometry.

    Science.gov (United States)

    Zheng, Chuhua; Wu, Qiong; Jin, Yan; Wu, Yanhong

    2017-11-02

    Modesty when defined as a personality trait, is highly beneficial to interpersonal relationship, group performance, and mental health. However, the potential neural underpinnings of trait modesty remain poorly understood. In the current study, we used voxel-based morphometry (VBM) to investigate the structural neural basis of trait modesty in Chinese college students. VBM results showed that higher trait modesty score was associated with lager regional gray matter volume in the dorsomedial prefrontal cortex, right dorsolateral prefrontal cortex, left superior temporal gyrus/left temporal pole, and right posterior insular cortex. These results suggest that individual differences in trait modesty are linked to brain regions associated with self-evaluation, self-regulation, and social cognition. The results remained robust after controlling the confounding factor of global self-esteem, suggesting unique structural correlates of trait modesty. These findings provide evidence for the structural neural basis of individual differences in trait modesty.

  6. Sporotrichosis-Associated Hospitalizations, United States, 2000–2013

    Science.gov (United States)

    Gold, Jeremy A.W.; Derado, Gordana; Mody, Rajal K.

    2016-01-01

    To determine frequency and risk for sporotrichosis-associated hospitalizations, we analyzed the US 2000–2013 National (Nationwide) Inpatient Sample. An estimated 1,471 hospitalizations occurred (average annual rate 0.35/1 million persons). Hospitalizations were associated with HIV/AIDS, immune-mediated inflammatory diseases, and chronic obstructive pulmonary disease. Although rare, severe sporotrichosis should be considered for at-risk patients. PMID:27648881

  7. Sporotrichosis-Associated Hospitalizations, United States, 2000-2013.

    Science.gov (United States)

    Gold, Jeremy A W; Derado, Gordana; Mody, Rajal K; Benedict, Kaitlin

    2016-10-01

    To determine frequency and risk for sporotrichosis-associated hospitalizations, we analyzed the US 2000-2013 National (Nationwide) Inpatient Sample. An estimated 1,471 hospitalizations occurred (average annual rate 0.35/1 million persons). Hospitalizations were associated with HIV/AIDS, immune-mediated inflammatory diseases, and chronic obstructive pulmonary disease. Although rare, severe sporotrichosis should be considered for at-risk patients.

  8. Sporotrichosis-Associated Hospitalizations, United States, 2000?2013

    OpenAIRE

    Gold, Jeremy A.W.; Derado, Gordana; Mody, Rajal K.; Benedict, Kaitlin

    2016-01-01

    To determine frequency and risk for sporotrichosis-associated hospitalizations, we analyzed the US 2000?2013 National (Nationwide) Inpatient Sample. An estimated 1,471 hospitalizations occurred (average annual rate 0.35/1 million persons). Hospitalizations were associated with HIV/AIDS, immune-mediated inflammatory diseases, and chronic obstructive pulmonary disease. Although rare, severe sporotrichosis should be considered for at-risk patients.

  9. Quadrupole moments of high spin states in the trans lead region

    International Nuclear Information System (INIS)

    Neyens, G.; Hardeman, F.; Nouwen, R.; S'heeren, G.; Van Den Bergh, M.; Cousement, R.

    1990-01-01

    The last few years, a lot of attention has been paid to the trans lead region. A reason for this has to be found in the fact that 208 Pb is a double magic core: both its proton and neutron shell are closed. This means that all nuclei in the lead region can be described well by the shell model, using a spherical 208 Pb core (spherical symmetric potential) and some valence particles or holes around it. The question is whether this model is also correct for high spin states. In this region, isomers with high angular momenta can only be created by alignment of all the spins of the valence particles and holes. And in some cases, alignment is not enough: core excitations are necessary to build up the large spin value of the isomeric state (e.g. the 63/2-isomer in 211 Rn. This means that a neutron pair from the closed N = 126 shell is broken up and one or both neutrons are excited to a level with higher energy and spin. The alignment of the valence-particle-spins causes an increase of the interactions between the valence particles (holes) on one hand, and between the valence particles (holes) and the hard core on the other hand. The latter interaction can cause a deformation of the core. The two interactions are taken into account in two different models: The SERI model (Spherical shell model with Empirical Residual Interactions) and the DIPM (Deformed Independent Particle Model). This paper reports that the effect of alignment of the spins of the valence particles in an isomeric state has been taken into account in the shell model by using residual interactions between the valence particles. These interactions are introduced in the theory in an empirical way or are calculated. Another model, the DIPM, takes into account the effect of alignment in a natural way: it starts from a deformed core (e.g. an axial symmetric potential) in which the valence particles are moving independently from each other)

  10. 76 FR 13209 - United States and State of Texas v. United Regional Health Care System; Proposed Final Judgment...

    Science.gov (United States)

    2011-03-10

    ... of Texas v. United Regional Health Care System, Civil Action No. 7:11-cv- 00030-O. On February 25..., ambulatory surgery center or radiology center in [a] 15 mile radius of United Regional Health Care System... 95% of billed charges for all inpatient and outpatient services at United Regional Health Care System...

  11. The United States Department of Energy's Regional Carbon Sequestration Partnerships Program Validation Phase.

    Science.gov (United States)

    Litynski, John T; Plasynski, Sean; McIlvried, Howard G; Mahoney, Christopher; Srivastava, Rameshwar D

    2008-01-01

    This paper reviews the Validation Phase (Phase II) of the Department of Energy's Regional Carbon Sequestration Partnerships initiative. In 2003, the U.S. Department of Energy created a nationwide network of seven Regional Carbon Sequestration Partnerships (RCSP) to help determine and implement the technology, infrastructure, and regulations most appropriate to promote carbon sequestration in different regions of the nation. The objectives of the Characterization Phase (Phase I) were to characterize the geologic and terrestrial opportunities for carbon sequestration; to identify CO(2) point sources within the territories of the individual partnerships; to assess the transportation infrastructure needed for future deployment; to evaluate CO(2) capture technologies for existing and future power plants; and to identify the most promising sequestration opportunities that would need to be validated through a series of field projects. The Characterization Phase was highly successful, with the following achievements: established a national network of companies and professionals working to support sequestration deployment; created regional and national carbon sequestration atlases for the United States and portions of Canada; evaluated available and developing technologies for the capture of CO(2) from point sources; developed an improved understanding of the permitting requirements that future sequestration activities will need to address as well as defined the gap in permitting requirements for large scale deployment of these technologies; created a raised awareness of, and support for, carbon sequestration as a greenhouse gas (GHG) mitigation option, both within industry and among the general public; identified the most promising carbon sequestration opportunities for future field tests; and established protocols for project implementation, accounting, and management. Economic evaluation was started and is continuing and will be a factor in project selection. During the

  12. Pregnancy-Associated Severe Sepsis: Contemporary State and Future Challenges.

    Science.gov (United States)

    Oud, Lavi

    2014-12-01

    Pregnancy is associated with an increased risk of infection related to its associated mechanical and physiological changes. Sepsis remains among the top causes of maternal death worldwide and is associated with substantial maternal morbidity. However, there are sparse data on pregnancy-associated severe sepsis (PASS), related in part to infrequent reports, varying case definitions and methodological approach, small cohort size, and often limited focus on severe sepsis in selected phases of pregnancy outcomes. Available reports vary, but indicate that PASS is a rare but likely increasing complication, and it is more likely to develop with increased maternal age, among minority women, the poor, those lacking health insurance, those with chronic illness or pregnancy-associated complications, and following invasive procedures. Obstetric sites of infection are the most prevalent, but non-obstetric infections often underlie pregnancy-associated severe sepsis, though the source of infection is often not readily apparent during initial care. Women with PASS can have a rapidly fatal course and require heightened clinician vigilance for early diagnosis and timely effective intervention. Nevertheless, available reports raise concerns about prevalent substandard care of these patients, contributing to adverse outcomes. The case fatality of PASS appears lower than that in the general population with severe sepsis, while the long-term outcomes of survivors remain unknown.

  13. State-dependent factors and attention in Whiplash Associated Disorder

    NARCIS (Netherlands)

    Blokhorst, Mariëtte G.B.G.

    2005-01-01

    The main aim of this thesis is to investigate the relationship between state- dependent factors (headache, neck pain, fatigue, distress) and attention in WAD patients. Furthermore, the focus is on ‘noise-distractibility’ and ‘noise- intolerance’, which are symptoms related to attention and often

  14. Analysis of aerosol optical depth evaluation in polar regions and associated uncertainties

    Directory of Open Access Journals (Sweden)

    P. Ortiz de Galisteo

    2008-04-01

    Full Text Available Some available processing algorithms used to calculate the aerosol optical depth from radiometric measurements were tested. The aim was to evaluate the associated uncertainties in polar regions due to the data processing, in order to adjust the methodology of the calculation and illustrate the importance of these error sources. The measurements were obtained during a sun photometer campaign in Ny-Ålesund within the framework of the POLAR-AOD project.

  15. LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies.

    Science.gov (United States)

    Iacobas, Ionela; Burrows, Patricia E; Frieden, Ilona J; Liang, Marilyn G; Mulliken, John B; Mancini, Anthony J; Kramer, Daniela; Paller, Amy S; Silverman, Robert; Wagner, Annette M; Metry, Denise W

    2010-11-01

    To define the clinical spectrum of regional congenital anomalies associated with large cutaneous hemangiomas of the lower half of the body, clarify risk for underlying anomalies on the basis of hemangioma location, and provide imaging guidelines for evaluation. We conducted a multi-institutional, retrospective case analysis of 24 new patients and review of 29 published cases. Hemangiomas in our series tended to be "segmental" and often "minimal growth" in morphology. Such lesions were often extensive, covering the entire leg. Extensive limb hemangiomas also showed potential for extracutaneous anomalies, including underlying arterial anomalies, limb underdevelopment, and ulceration. The cutaneous hemangioma and underlying anomalies demonstrated regional correlation. Myelopathies were the most common category of associated anomalies. We propose the acronym "LUMBAR" to describe the association of Lower body hemangioma and other cutaneous defects, Urogenital anomalies, Ulceration, Myelopathy, Bony deformities, Anorectal malformations, Arterial anomalies, and Renal anomalies. There are many similarities between LUMBAR and PHACE syndrome, which might be considered regional variations of the same. Although guidelines for imaging are suggested, prospective studies will lead to precise imaging recommendations and help determine true incidence, risk and long-term outcomes. Copyright © 2010 Mosby, Inc. All rights reserved.

  16. Association of genetic variations in the mitochondrial DNA control region with presbycusis.

    Science.gov (United States)

    Falah, Masoumeh; Farhadi, Mohammad; Kamrava, Seyed Kamran; Mahmoudian, Saeid; Daneshi, Ahmad; Balali, Maryam; Asghari, Alimohamad; Houshmand, Massoud

    2017-01-01

    The prominent role of mitochondria in the generation of reactive oxygen species, cell death, and energy production contributes to the importance of this organelle in the intracellular mechanism underlying the progression of the common sensory disorder of the elderly, presbycusis. Reduced mitochondrial DNA (mtDNA) gene expression and coding region variation have frequently been reported as being associated with the development of presbycusis. The mtDNA control region regulates gene expression and replication of the genome of this organelle. To comprehensively understand of the role of mitochondria in the progression of presbycusis, we compared variations in the mtDNA control region between subjects with presbycusis and controls. A total of 58 presbycusis patients and 220 control subjects were enrolled in the study after examination by the otolaryngologist and audiology tests. Variations in the mtDNA control region were investigated by polymerase chain reaction and Sanger sequencing. A total of 113 sequence variants were observed in mtDNA, and variants were detected in 100% of patients, with 84% located in hypervariable regions. The frequencies of the variants, 16,223 C>T, 16,311 T>C, 16,249 T>C, and 15,954 A>C, were significantly different between presbycusis and control subjects. The statistically significant difference in the frequencies of four nucleotide variants in the mtDNA control region of presbycusis patients and controls is in agreement with previous experimental evidence and supports the role of mitochondria in the intracellular mechanism underlying presbycusis development. Moreover, these variants have potential as diagnostic markers for individuals at a high risk of developing presbycusis. The data also suggest the possible presence of changes in the mtDNA control region in presbycusis, which could alter regulatory factor binding sites and influence mtDNA gene expression and copy number.

  17. Monitoring the expansion of built-up areas in Seberang Perai region, Penang State, Malaysia

    International Nuclear Information System (INIS)

    Samat, N

    2014-01-01

    Rapid urbanization has caused land use transformation and encroachment of built environment into arable agriculture land. Uncontrolled expansion could bring negative impacts to society, space and the environment. Therefore, information on expansion and future spatial pattern of built-up areas would be useful for planners and decision makers in formulating policies towards managing and planning for sustainable urban development. This study demonstrates the usage of Geographic Information System in monitoring the expansion of built-up area in Seberang Perai region, Penang State, Malaysia. Built-up area has increased by approximately 20% between 1990 and 2001 and further increased by 12% between 2001 and 2007. New development is expected to continue encroach into existing open space and agriculture area since those are the only available land in this study area. The information on statistics of the expansion of built-up area and future spatial pattern of urban expansion were useful in planning and managing urban spatial growth

  18. Photoionization cross section measurements of the excited states of cobalt in the near-threshold region

    Directory of Open Access Journals (Sweden)

    Xianfeng Zheng

    2014-10-01

    Full Text Available We present measurements of photoionization cross-sections of the excited states of cobalt using a two-color, two-step resonance ionization technique in conjunction with a molecular beam time of flight (TOF mass spectrometer. The atoms were produced by the laser vaporization of a cobalt rod, coupled with a supersonic gas jet. The absolute photoionization cross-sections at threshold and near-threshold regions (0-1.2 eV were measured, and the measured values ranged from 4.2±0.7 Mb to 10.5±1.8 Mb. The lifetimes of four odd parity energy levels are reported for the first time.

  19. Herpetofauna, municipality of Porto Murtinho, Chaco region, state of Mato Grosso do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Souza, F. L.

    2010-01-01

    Full Text Available Among the physiographic regions included in the central South American diagonal of open formations,the Chaco, with some endemic species, represents the southernmost dry area. In Brazil, the Chaco is foundin southwestern corner of Mato Grosso do Sul state, mostly in the municipality of Porto Murtinho along theParaguay and Apa rivers. From February 2008 to December 2009, we carried out an inventory of amphibiansand reptiles in Porto Murtinho, using pitfall traps, time-limited searches, and occasional encounters. A total of34 amphibian and 39 reptile species were registered. Although some typical Chacoan species were found, mostof the species are open area dwellers that also occur in other open biomes, such as the Cerrado and Caatinga.

  20. Important historical efforts at emergency department categorization in the United States and implications for regionalization.

    Science.gov (United States)

    Mehrotra, Abhishek; Sklar, David P; Tayal, Vivek S; Kocher, Keith E; Handel, Daniel A; Myles Riner, R

    2010-12-01

    This article is drawn from a report created for the American College of Emergency Physicians (ACEP) Emergency Department (ED) Categorization Task Force and also reflects the proceedings of a breakout session, "Beyond ED Categorization-Matching Networks to Patient Needs," at the 2010 Academic Emergency Medicine consensus conference, "Beyond Regionalization: Integrated Networks of Emergency Care." The authors describe a brief history of the significant national and state efforts at categorization and suggest reasons why many of these efforts failed to persevere or gain wider implementation. The history of efforts to categorize hospital (and ED) emergency services demonstrates recognition of the potential benefits of categorization, but reflects repeated failures to implement full categorization systems or limited excursions into categorization through licensing of EDs or designation of receiving and referral facilities. An understanding of the history of hospital and ED categorization could better inform current efforts to develop categorization schemes and processes. 2010 by the Society for Academic Emergency Medicine.

  1. Lichens as indicators of the atmosphere state in the oil exploration district of Tomsk Region

    Science.gov (United States)

    Bolshunova, Tatiana; Ivan, Podkozlin

    2013-04-01

    Lichens are widespread in the vegetative cover of West Siberia, particularly in the north. They play an important role in the migration and transformation of chemical pollutants. Lichens lack waxy cuticles and are largely dependent on the atmosphere for their water and nutrient uptake. Lichens are not only studied and used as indicators, but also as accumulators, e.g. for trace and heavy metals. In fact, lichens are known for their ability to accumulate airborne substances to concentrations far greater those in the atmosphere, and the element contents of lichen thalli proved to be directly correlated with environmental levels. Monitoring of the atmosphere pollution using lichens is more efficient than that using snow cover. Because of the long lichen life it is possible to obtain persistent mean characteristics of the ecosystems state. Epiphytic lichens, growing on tree stems are more appropriate to use than that which grow on soil. Epiphytic lichens are more sensitive to changes of the chemical composition of the atmosphere. Pollutants penetrate in the lichen thalli from the atmosphere together with precipitations and dust. Moreover the precipitations are saturated with pollutants when going through crowns of trees and trickling down the steams and branches. Lichen studies are especially important in territories subjected to excessive human activity. Because a great part of Tomsk region (West Siberia, Russia) is the territory of the oil-field exploration, there the atmosphere monitoring is a necessary part of the whole environmental monitoring. The aim of this investigation is the estimation of the influence of oil exploration industry in Tomsk region on the atmosphere by means of the study of epiphytic lichens. Lichen samples were collected in August and September 2010-2011. Sampling net included seven areas distributed inside the oil-exploration districts of Tomsk region. In total 27 samples were collected. In these samples 53 chemical elements were detected by

  2. Patterns of active and passive smoking, and associated factors, in the South-east Anatolian Project (SEAP region in Turkey

    Directory of Open Access Journals (Sweden)

    Ceylan Ali

    2006-01-01

    Full Text Available Abstract Background Smoking is an important health threat in Turkey. This study aimed to determine the frequency of and main factors associated with smoking in persons of 15 years and over, and the frequency of passive smoking in homes in the South-east Anatolian Project (SEAP Region in Turkey. Methods A cross sectional design was employed. The sample waschosen by the State Institute of Statistics using a stratified cluster probability sampling method. 1126 houses representing the SEAP Region were visited. Questionnaires about tobacco smoking and related factors were applied to 2166 women and 1906 men (of 15 years old and above in their homes. Face-to-face interview methods were employed. Participants were classified as current, ex, and non-smokers. The presence of a regular daily smoker in a house was used as an indication of passive smoking. The chi-square andlogistic regressionanalysis methods were used for the statistical analysis. Results The prevalence of smoking, in those of 15 years and over, was 11.8% in women and 49.7% in men. The prevalence of current smokers was higher in urban (34.5 % than in rural (22.8 % regions. The mean of total cigarette consumption was 6.5 packs/year in women and 17.9 packs/year in men. There was at least one current smoker in 70.1% of the houses. Conclusion Smoking is a serious problem in the South-eastern Anatolian Region. Male gender, middle age, a high level of education and urban residency were most strongly associated with smoking.

  3. Impact of Regional Differences within State on the Factors Influencing Youth Entrepreneurship--A Case of Garhwal and Kumaun Regions of Uttarakhand

    Science.gov (United States)

    Sharma, Lalit

    2015-01-01

    Lee, Chang & Lim (2005) state that the impact of entrepreneurship education in each country is different because of each country's unique culture with regard to entrepreneurship. Going by the above argument, this research paper intends to make a formal enquiry on whether the above effect holds true for different regions within a particular…

  4. Climate and climate variability of the wind power resources in the Great Lakes region of the United States

    Science.gov (United States)

    X. Li; S. Zhong; X. Bian; W.E. Heilman

    2010-01-01

    The climate and climate variability of low-level winds over the Great Lakes region of the United States is examined using 30 year (1979-2008) wind records from the recently released North American Regional Reanalysis (NARR), a three-dimensional, high-spatial and temporal resolution, and dynamically consistent climate data set. The analyses focus on spatial distribution...

  5. 78 FR 68060 - Availability of FY 12 Grantee Performance Evaluation Reports for the Eight States of EPA Region 4...

    Science.gov (United States)

    2013-11-13

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9902-81--Region 4] Availability of FY 12 Grantee Performance Evaluation Reports for the Eight States of EPA Region 4 and 17 Local Agencies AGENCY: Environmental... evaluation reports. SUMMARY: EPA's grant regulations require the Agency to evaluate the performance of...

  6. 75 FR 48986 - Vendor Outreach Workshop for Small Businesses in the National Capitol Region of the United States

    Science.gov (United States)

    2010-08-12

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Vendor Outreach Workshop for Small Businesses in the National Capitol Region of the United States AGENCY: Office of the Secretary, Interior. ACTION... Interior are hosting a Vendor Outreach Workshop for small businesses in the National Capitol region of the...

  7. Indicators of wetland condition for the prairie pothole region of the United States.

    Science.gov (United States)

    Guntenspergen, G R; Peterson, S A; Leibowitz, S G; Cowardin, L M

    2002-09-01

    We describe a study designed to evaluate the performance of wetland condition indicators of the Prairie Pothole Region (PPR) of the north central United States. Basin and landscape scale indicators were tested in 1992 and 1993 to determine their ability to discriminate between the influences of grassland dominated and cropland dominated landscapes in the PPR. Paired plots were selected from each of the major regions of the PPR. Among the landscape scale indicators tested, those most capable of distinguishing between the two landscapes were: 1) frequency of drained wetland basins. 2) total length of drainage ditch per plot, 3) amount of exposed soil in the upland subject to erosion, 4) indices of change in area of wetland covered by water, and 5) number of breeding duck pairs. Basin scale indicators including soil phosphorus concentrations and invertebrate taxa richness showed some promise: however, plant species richness was the only statistically significant basin scale indicator distinguishing grassland dominated from cropland dominated landscapes. Although our study found a number of promising candidate indicators, one of our conclusions is that basin scale indicators present a number of implementation problems. including: skill level requirements, site access denials, and recession of site access by landowners. Alternatively, we suggest that the use of landscape indicators based on remote sensing can be an effective means of assessing wetland integrity.

  8. Cost of paricá wood production in Paragominas region, Para State, Brazil

    Directory of Open Access Journals (Sweden)

    Rafaela da Silveira

    2017-12-01

    Full Text Available The silvicultural and economic potential of paricá (Schizolobium amazonicum has encouraged the expansion of this crop, mainly in the northern region of the country, provoking the need for studies on the species. The objective of this study was to estimate paricá production in Paragominas region, Para State, Brazil, at 5, 6 and 7 years, in three classes of productivity considering five plant arrangements, being identified the main costs of production, in addition to those most affected by plant arrangements. The volumetric estimation was obtained by modeling in population level and the analysis of the costs, through the methodology of the operational cost. It was possible to infer that the arrangement of plants 3 m x 2 m was superior in volume, compared to the other analyzed plant arrangements. The effective operating cost represented on average 65% of the total production costs. Transport was the most significant individual cost, in all analyzed plant arrangements. The maintenance, among the set of activities, was the most significant in planting, fact that may be related to the number and the long period for the activities execution. Smaller plant arrangements presented the higher total costs of production, depending or not on the remuneration for the use of the permanent and current capital.

  9. [Regional cerebral oxygen saturation as a marker of hemodynamic state following cardiac surgery].

    Science.gov (United States)

    García-Hernández, J A; Aldemira-Liz, A; Martínez-López, A I; Cayuela, A; Charlo-Molina, M T; Cano-Franco, J; Loscertales-Abril, M

    2013-10-01

    Regional cerebral oxygen saturation (rSO₂) is a measure of the general state of perfusion and oxygenation. We aim to analyze the relationship between this and various hemodynamic and respiratory parameters. Forty-three patients, operated on between October 2011 and July 2012, were included in this prospective observational descriptive study. The following parameters were measured: mean arterial pressure, both arterial and central venous oxygen saturation and partial pressures of oxygen and carbon dioxide, and lactate levels. From these parameters, the oxygenation index and the oxygen extraction ratio were calculated. These measurements were studied to evaluate whether rSO₂ correlated significantly with the other parameters. The average age and weight of the patients were 27.3 months and 9.2 kg, respectively. The rSO₂ correlated positively with both central venous oxygen saturation (r=0.73, P 0.4) between the rSO₂ and central venous oxygen saturation, and between the rSO₂ and oxygen extraction ratio. Regional cerebral oxygen saturation correlates well with hemodynamic parameters - mean arterial pressure, venous saturation, and the tissue oxygen extraction. However, it does not correlate with respiratory parameters. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  10. Characterization of heavy metals in a uranium ore region of the state of Pernambuco, Brazil.

    Science.gov (United States)

    Bezerra, Jairo Dias; dos Santos Amaral, Romilton; dos Santos Júnior, José Araújo; Genezini, Frederico Antonio; Menezes, Rômulo Simões Cezar; de Oliveira, Iane Andrade

    2014-03-01

    The concentrations of As, Zn, Co, Cr, and Ba were determined in soil samples from an anomalous uranium ore region in the countryside of the state of Pernambuco, Brazil. The main land use system in this region is dairy farming, and there is a need to evaluate the potential risk of milk contamination. Twenty-three soil samples were activated with neutrons and analyzed using a high-resolution gamma-ray spectrometer system. The results, recorded in mg kg(-1), varied from 0.4 to 6.7 for As, from 17.0 to 110.0 for Zn, from 2.8 to 38.4 for Co, from 12.1 to 65.5 for Cr, and from 443.0 to 1,497.0 for Ba. All of the Ba concentrations were higher than the intervention value adopted by the Brazilian National Environmental Board. This finding justifies research in other environmental areas to predict the toxicological risks to the local population.

  11. Altered resting-state connectivity within default mode network associated with late chronotype.

    Science.gov (United States)

    Horne, Charlotte Mary; Norbury, Ray

    2018-04-20

    Current evidence suggests late chronotype individuals have an increased risk of developing depression. However, the underlying neural mechanisms of this association are not fully understood. Forty-six healthy, right-handed individuals free of current or previous diagnosis of depression, family history of depression or sleep disorder underwent resting-state functional Magnetic Resonance Imaging (rsFMRI). Using an Independent Component Analysis (ICA) approach, the Default Mode Network (DMN) was identified based on a well validated template. Linear effects of chronotype on DMN connectivity were tested for significance using non-parametric permutation tests (applying 5000 permutations). Sleep quality, age, gender, measures of mood and anxiety, time of scan and cortical grey matter volume were included as covariates in the regression model. A significant positive correlation between chronotype and functional connectivity within nodes of the DMN was observed, including; bilateral PCC and precuneus, such that later chronotype (participants with lower rMEQ scores) was associated with decreased connectivity within these regions. The current results appear consistent with altered DMN connectivity in depressed patients and weighted evidence towards reduced DMN connectivity in other at-risk populations which may, in part, explain the increased vulnerability for depression in late chronotype individuals. The effect may be driven by self-critical thoughts associated with late chronotype although future studies are needed to directly investigate this. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. Resting-state functional connectivity of the default mode network associated with happiness.

    Science.gov (United States)

    Luo, Yangmei; Kong, Feng; Qi, Senqing; You, Xuqun; Huang, Xiting

    2016-03-01

    Happiness refers to people's cognitive and affective evaluation of their life. Why are some people happier than others? One reason might be that unhappy people are prone to ruminate more than happy people. The default mode network (DMN) is normally active during rest and is implicated in rumination. We hypothesized that unhappiness may be associated with increased default-mode functional connectivity during rest, including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC) and inferior parietal lobule (IPL). The hyperconnectivity of these areas may be associated with higher levels of rumination. One hundred forty-eight healthy participants underwent a resting-state fMRI scan. A group-independent component analysis identified the DMNs. Results indicated increased functional connectivity in the DMN was associated with lower levels of happiness. Specifically, relative to happy people, unhappy people exhibited greater functional connectivity in the anterior medial cortex (bilateral MPFC), posterior medial cortex regions (bilateral PCC) and posterior parietal cortex (left IPL). Moreover, the increased functional connectivity of the MPFC, PCC and IPL, correlated positively with the inclination to ruminate. These results highlight the important role of the DMN in the neural correlates of happiness, and suggest that rumination may play an important role in people's perceived happiness. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  13. Associations between initial change in physical activity level and subsequent change in regional body fat distributions.

    Science.gov (United States)

    Ezekwe, Kelechi A; Adegboye, Amanda R A; Gamborg, Michael; Heitmann, Berit L

    2013-01-01

    Few studies have examined which lifestyle factors relate to the development of fat distribution. Therefore, the identification of the determinants of changes in fat deposition is highly relevant. The association between the change in physical activity (PA) and the subsequent changes in regional body fat distributions was examined. In total, 1,236 men and 1,201 women were included at baseline and participated in the Danish MONICA (MONItoring Trends and Determinants in CArdiovascular Disease) study. A questionnaire was used to assess PA at 5 and 11 years after baseline examination, while waist circumference (WC) and hip circumference (HC) were measured at both follow-ups. Among men, WC increased in the constant active group to a lesser extent than in the non-constant active group (3.4 vs. 4.1 cm; p = 0.03) concerning leisure time physical activities (LTPA). A similar pattern was observed for both WC and HC in relation to occupational physical activities (OPA) (p = 0.02). Among women, the results went in the same direction for LTPA, whereas the associations with OPA were in the opposite direction (p = 0.001). LTPA and OPA were associated with reduced subsequent 6-year changes in regional fat distribution for men. For women, no associations were observed in relation to WC; however, OPA seemed to increase HC among women. © 2013 S. Karger GmbH, Freiburg.

  14. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

    International Nuclear Information System (INIS)

    Dyke, A. L. V.

    2009-01-01

    In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores. Smoking-SNP interactions were explored, and haplotype in TERT and GHR associated with NSCLC risk were identified. The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration

  15. Associations among Wine Grape Microbiome, Metabolome, and Fermentation Behavior Suggest Microbial Contribution to Regional Wine Characteristics

    Science.gov (United States)

    Bokulich, Nicholas A.; Collins, Thomas S.; Masarweh, Chad; Allen, Greg; Heymann, Hildegarde; Ebeler, Susan E.

    2016-01-01

    ABSTRACT Regionally distinct wine characteristics (terroir) are an important aspect of wine production and consumer appreciation. Microbial activity is an integral part of wine production, and grape and wine microbiota present regionally defined patterns associated with vineyard and climatic conditions, but the degree to which these microbial patterns associate with the chemical composition of wine is unclear. Through a longitudinal survey of over 200 commercial wine fermentations, we demonstrate that both grape microbiota and wine metabolite profiles distinguish viticultural area designations and individual vineyards within Napa and Sonoma Counties, California. Associations among wine microbiota and fermentation characteristics suggest new links between microbiota, fermentation performance, and wine properties. The bacterial and fungal consortia of wine fermentations, composed from vineyard and winery sources, correlate with the chemical composition of the finished wines and predict metabolite abundances in finished wines using machine learning models. The use of postharvest microbiota as an early predictor of wine chemical composition is unprecedented and potentially poses a new paradigm for quality control of agricultural products. These findings add further evidence that microbial activity is associated with wine terroir. PMID:27302757

  16. Emergence of Viral hemorrhagic septicemia virus in the North American Great Lakes region is associated with low viral genetic diversity.

    Science.gov (United States)

    Thompson, Tarin M; Batts, William N; Faisal, Mohamed; Bowser, Paul; Casey, James W; Phillips, Kenneth; Garver, Kyle A; Winton, James; Kurath, Gael

    2011-08-29

    Viral hemorrhagic septicemia virus (VHSV) is a fish rhabdovirus that causes disease in a broad range of marine and freshwater hosts. The known geographic range includes the Northern Atlantic and Pacific Oceans, and recently it has invaded the Great Lakes region of North America. The goal of this work was to characterize genetic diversity of Great Lakes VHSV isolates at the early stage of this viral emergence by comparing a partial glycoprotein (G) gene sequence (669 nt) of 108 isolates collected from 2003 to 2009 from 31 species and at 37 sites. Phylogenetic analysis showed that all isolates fell into sub-lineage IVb within the major VHSV genetic group IV. Among these 108 isolates, genetic diversity was low, with a maximum of 1.05% within the 669 nt region. There were 11 unique sequences, designated vcG001 to vcG011. Two dominant sequence types, vcG001 and vcG002, accounted for 90% (97 of 108) of the isolates. The vcG001 isolates were most widespread. We saw no apparent association of sequence type with host or year of isolation, but we did note a spatial pattern, in which vcG002 isolates were more prevalent in the easternmost sub-regions, including inland New York state and the St. Lawrence Seaway. Different sequence types were found among isolates from single disease outbreaks, and mixtures of types were evident within 2 isolates from individual fish. Overall, the genetic diversity of VHSV in the Great Lakes region was found to be extremely low, consistent with an introduction of a new virus into a geographic region with previously naive host populations.

  17. Emergence of viral hemorrhagic septicemia virus in the North American Great Lakes region is associated with low viral genetic diversity

    Science.gov (United States)

    Thompson, T.M.; Batts, W.N.; Faisal, M.; Bowser, P.; Casey, J.W.; Phillips, K.; Garver, K.A.; Winton, J.; Kurath, G.

    2011-01-01

    Viral hemorrhagic septicemia virus (VHSV) is a fish rhabdovirus that causes disease in a broad range of marine and freshwater hosts. The known geographic range includes the Northern Atlantic and Pacific Oceans, and recently it has invaded the Great Lakes region of North Ame­rica. The goal of this work was to characterize genetic diversity of Great Lakes VHSV isolates at the early stage of this viral emergence by comparing a partial glycoprotein (G) gene sequence (669 nt) of 108 isolates collected from 2003 to 2009 from 31 species and at 37 sites. Phylogenetic analysis showed that all isolates fell into sub-lineage IVb within the major VHSV genetic group IV. Among these 108 isolates, genetic diversity was low, with a maximum of 1.05% within the 669 nt region. There were 11 unique sequences, designated vcG001 to vcG011. Two dominant sequence types, vcG001 and vcG002, accounted for 90% (97 of 108) of the isolates. The vcG001 isolates were most widespread. We saw no apparent association of sequence type with host or year of isolation, but we did note a spatial pattern, in which vcG002 isolates were more prevalent in the easternmost sub-regions, including inland New York state and the St. Lawrence Seaway. Different sequence types were found among isolates from single disease outbreaks, and mixtures of types were evident within 2 isolates from ­individual fish. Overall, the genetic diversity of VHSV in the Great Lakes region was found to be extremely low, consistent with an introduction of a new virus into a geographic region with ­previously naïve host populations.

  18. Individual differences in the spontaneous recruitment of brain regions supporting mental state understanding when viewing natural social scenes.

    Science.gov (United States)

    Wagner, Dylan D; Kelley, William M; Heatherton, Todd F

    2011-12-01

    People are able to rapidly infer complex personality traits and mental states even from the most minimal person information. Research has shown that when observers view a natural scene containing people, they spend a disproportionate amount of their time looking at the social features (e.g., faces, bodies). Does this preference for social features merely reflect the biological salience of these features or are observers spontaneously attempting to make sense of complex social dynamics? Using functional neuroimaging, we investigated neural responses to social and nonsocial visual scenes in a large sample of participants (n = 48) who varied on an individual difference measure assessing empathy and mentalizing (i.e., empathizing). Compared with other scene categories, viewing natural social scenes activated regions associated with social cognition (e.g., dorsomedial prefrontal cortex and temporal poles). Moreover, activity in these regions during social scene viewing was strongly correlated with individual differences in empathizing. These findings offer neural evidence that observers spontaneously engage in social cognition when viewing complex social material but that the degree to which people do so is mediated by individual differences in trait empathizing.

  19. Management and control of parasites on dairy farms in northwestern region of São Paulo state

    Directory of Open Access Journals (Sweden)

    Cecília José Veríssimo

    Full Text Available Abstract Dairy cattle farming is of great economic and social importance in all Brazilian’s regions. Parasites can reduce milk productivity, especially the tick Rhipicephalus (Boophilus microplus. This study consisted of a questionnaire answered by 40 milk producers in the northwestern region of the State of São Paulo. The aim was to ascertain how these producers controlled ticks and other parasites. Very many of them knew nothing about the biological cycle of the cattle tick or about strategic control or acaricide efficacy tests. The majority (87.5% controlled ticks at a high frequency, without technical criteria and care to apply the acaricide. Spraying was the most used mode of acaricide application (95% and endectocides were used by 45%. Cattle tick fever was the harm most associated with ticks (87.5% followed closely by screwworm (77.5%. However, 65% were satisfied with their tick control. About the control of others parasites, all dewormed at least twice a year their animals; 65% were controlling horn fly; 40% had problems with screwworm. The interviewers had in general good level of education and the farms generally exhibited a high degree of technology for milk production on pasture because half of them received technical assistance frequently.

  20. The comparative burden of salmonellosis in the European Union member states, associated and candidate countries

    Directory of Open Access Journals (Sweden)

    de Jong Birgitta

    2006-01-01

    Full Text Available Abstract Background Salmonella is an infectious agents causing numerous cases of illness each year, and thereby having significant economic impact. Using returning Swedish travellers we estimated the burden of salmonellosis in different European countries. Methods From the Swedish database on notifiable communicable diseases 15,864 cases with travel-associated salmonellosis acquired in Europe from 1997–2003 were retrieved. These cases were compared to a dataset from the same years on 14,171 randomly selected Swedish residents, with a history of recent overnight travel in Europe. Distribution of salmonellosis in returning travellers and the distribution of Salmonella Enteritidis was analysed for different member states in the European Union, associated and candidate countries. The risk of being notified with a salmonella infection after return from each European country/region was calculated, and compared with official reporting data rom these countries. Using Norway as reference country, we could 1 construct comparable incidence estimates and 2 calculate the "under-reporting" in each country compared to Norway. Results The highest burden of salmonellosis was estimated for Bulgaria (2741/100,000, followed by Turkey with 2344/100 000 and Malta with 2141/100 000. S. Enteritidis is the dominating serotype, 66.9 % of all cases and phage type 4 accounts for 37.5 % of the S. Enteritidis cases Conclusion Using returning tourists as a sentinel population can provide a useful base for comparison of disease burdens in different countries/regions. Focusing prevention of salmonellosis to prevention of egg and poultry associated S. Enteritidis infection will have a major impact from a public health perspective and will significantly lower the burden of disease in most European countries.

  1. The Association between State Policy Environments and Self-Rated Health Disparities for Sexual Minorities in the United States

    Directory of Open Access Journals (Sweden)

    Gilbert Gonzales

    2018-06-01

    Full Text Available A large body of research has documented disparities in health and access to care for lesbian, gay, and bisexual (LGB people in the United States. Less research has examined how the level of legal protection afforded to LGB people (the state policy environment affects health disparities for sexual minorities. This study used data on 14,687 sexual minority adults and 490,071 heterosexual adults from the 2014–2016 Behavioral Risk Factor Surveillance System to document differences in health. Unadjusted state-specific prevalence estimates and multivariable logistic regression models were used to compare poor/fair self-rated health by gender, sexual minority status, and state policy environments (comprehensive versus limited protections for LGB people. We found disparities in self-rated health between sexual minority adults and heterosexual adults in most states. On average, sexual minority men in states with limited protections and sexual minority women in states with either comprehensive or limited protections were more likely to report poor/fair self-rated health compared to their heterosexual counterparts. This study adds new findings on the association between state policy environments and self-rated health for sexual minorities and suggests differences in this relationship by gender. The associations and impacts of state-specific policies affecting LGB populations may vary by gender, as well as other intersectional identities.

  2. Culture-proven early-onset neonatal sepsis in Arab states in the Gulf region: two-year prospective study

    Directory of Open Access Journals (Sweden)

    Majeda S. Hammoud

    2017-02-01

    Conclusions: The incidence of EOS and the patterns of the causative organisms in the Arab states in the Gulf region are similar to those in developed countries before the era of intrapartum antibiotic prophylaxis. Efforts should be made to improve intrapartum antibiotic prophylaxis in the Arab state setting, which could avert large numbers of GBS infections.

  3. Scaling net ecosystem production and net biome production over a heterogeneous region in the Western United States

    Science.gov (United States)

    D.P. Turner; W.D. Ritts; B.E. Law; W.B. Cohen; Z. Yan; T. Hudiburg; J.L. Campbell; M. Duane

    2007-01-01

    Bottom-up scaling of net ecosystem production (NEP) and net biome production (NBP) was used to generate a carbon budget for a large heterogeneous region (the state of Oregon, 2.5x105 km2 ) in the Western United States. Landsat resolution (30 m) remote sensing provided the basis for mapping land cover and disturbance history...

  4. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.

    Directory of Open Access Journals (Sweden)

    Lauren A Vanderlinden

    Full Text Available To identify brain transcriptional networks that may predispose an animal to consume alcohol, we used weighted gene coexpression network analysis (WGCNA. Candidate coexpression modules are those with an eigengene expression level that correlates significantly with the level of alcohol consumption across a panel of BXD recombinant inbred mouse strains, and that share a genomic region that regulates the module transcript expression levels (mQTL with a genomic region that regulates alcohol consumption (bQTL. To address a controversy regarding utility of gene expression profiles from whole brain, vs specific brain regions, as indicators of the relationship of gene expression to phenotype, we compared candidate coexpression modules from whole brain gene expression data (gathered with Affymetrix 430 v2 arrays in the Colorado laboratories and from gene expression data from 6 brain regions (nucleus accumbens (NA; prefrontal cortex (PFC; ventral tegmental area (VTA; striatum (ST; hippocampus (HP; cerebellum (CB available from GeneNetwork. The candidate modules were used to construct candidate eigengene networks across brain regions, resulting in three "meta-modules", composed of candidate modules from two or more brain regions (NA, PFC, ST, VTA and whole brain. To mitigate the potential influence of chromosomal location of transcripts and cis-eQTLs in linkage disequilibrium, we calculated a semi-partial correlation of the transcripts in the meta-modules with alcohol consumption conditional on the transcripts' cis-eQTLs. The function of transcripts that retained the correlation with the phenotype after correction for the strong genetic influence, implicates processes of protein metabolism in the ER and Golgi as influencing susceptibility to variation in alcohol consumption. Integration of these data with human GWAS provides further information on the function of polymorphisms associated with alcohol-related traits.

  5. LARGE SOLAR ENERGETIC PARTICLE EVENTS ASSOCIATED WITH FILAMENT ERUPTIONS OUTSIDE ACTIVE REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    Gopalswamy, N.; Mäkelä, P.; Akiyama, S.; Yashiro, S.; Xie, H.; Thakur, N. [Solar Physics Laboratory, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Kahler, S. W., E-mail: nat.gopalswamy@nasa.gov [Air Force Research Laboratory, Albuquerque, NM 87117 (United States)

    2015-06-10

    We report on four large filament eruptions (FEs) from solar cycles 23 and 24 that were associated with large solar energetic particle (SEP) events and interplanetary type II radio bursts. The post-eruption arcades corresponded mostly to C-class soft X-ray enhancements, but an M1.0 flare was associated with one event. However, the associated coronal mass ejections (CMEs) were fast (speeds ∼ 1000 km s{sup −1}) and appeared as halo CMEs in the coronagraph field of view. The interplanetary type II radio bursts occurred over a wide wavelength range, indicating the existence of strong shocks throughout the inner heliosphere. No metric type II bursts were present in three events, indicating that the shocks formed beyond 2–3 Rs. In one case, there was a metric type II burst with low starting frequency, indicating a shock formation height of ∼2 Rs. The FE-associated SEP events did have softer spectra (spectral index >4) in the 10–100 MeV range, but there were other low-intensity SEP events with spectral indices ≥4. Some of these events are likely FE-SEP events, but were not classified as such in the literature because they occurred close to active regions. Some were definitely associated with large active region flares, but the shock formation height was large. We definitely find a diminished role for flares and complex type III burst durations in these large SEP events. Fast CMEs and shock formation at larger distances from the Sun seem to be the primary characteristics of the FE-associated SEP events.

  6. Associations between accelerometer-derived physical activity and regional adiposity in young men and women.

    Science.gov (United States)

    Smith, H A; Storti, K L; Arena, V C; Kriska, A M; Gabriel, K K Pettee; Sutton-Tyrrell, K; Hames, K C; Conroy, M B

    2013-06-01

    Empirical evidence supports an inverse relationship between physical activity (PA) and adiposity, but studies using detailed measures of both are scarce. The relationship between regional adiposity and accelerometer-derived PA in men and women are described. Cross-sectional analysis included 253 participants from a weight loss study limited to ages 20-45 years and BMI 25-39.9 kg m(-2) . PA data were collected with accelerometers and expressed as total accelerometer counts and average amount of time per day accumulated in different intensity levels [sedentary, light-, and moderate-to-vigorous intensity PA (MVPA)]. Accumulation of time spent above 100 counts was expressed as total active time. Computed tomography (CT) was used to measure abdominal and adipose tissue (AT). Multivariate linear regression analyses were used to assess the relationship between regional adiposity (dependent variable) and the various PA levels (independent variable), and were executed separately for men and women, adjusting for wear time, age, race, education, and BMI. Among males, light activity was inversely associated with total AT (β = -0.19; P = 0.02) as well as visceral AT (VAT) (β = -0.30; P = 0.03). Among females sedentary time was positively associated with VAT (β = 0.11; P = 0.04) and total active time was inversely associated with VAT (β = -0.12; P = 0.04). Findings from this study suggest that PA intensity level may influence regional adiposity differently in men and women. Additional research is needed in larger samples to clarify the difference in these associations by sex, create recommendations for the frequency, duration and intensity of PA needed to target fat deposits, and determine if these recommendations should differ by sex. Copyright © 2013 The Obesity Society.

  7. Integration of association statistics over genomic regions using Bayesian adaptive regression splines

    Directory of Open Access Journals (Sweden)

    Zhang Xiaohua

    2003-11-01

    Full Text Available Abstract In the search for genetic determinants of complex disease, two approaches to association analysis are most often employed, testing single loci or testing a small group of loci jointly via haplotypes for their relationship to disease status. It is still debatable which of these approaches is more favourable, and under what conditions. The former has the advantage of simplicity but suffers severely when alleles at the tested loci are not in linkage disequilibrium (LD with liability alleles; the latter should capture more of the signal encoded in LD, but is far from simple. The complexity of haplotype analysis could be especially troublesome for association scans over large genomic regions, which, in fact, is becoming the standard design. For these reasons, the authors have been evaluating statistical methods that bridge the gap between single-locus and haplotype-based tests. In this article, they present one such method, which uses non-parametric regression techniques embodied by Bayesian adaptive regression splines (BARS. For a set of markers falling within a common genomic region and a corresponding set of single-locus association statistics, the BARS procedure integrates these results into a single test by examining the class of smooth curves consistent with the data. The non-parametric BARS procedure generally finds no signal when no liability allele exists in the tested region (ie it achieves the specified size of the test and it is sensitive enough to pick up signals when a liability allele is present. The BARS procedure provides a robust and potentially powerful alternative to classical tests of association, diminishes the multiple testing problem inherent in those tests and can be applied to a wide range of data types, including genotype frequencies estimated from pooled samples.

  8. Immunochip analysis identifies association of the RAD50/IL13 region with human longevity.

    Science.gov (United States)

    Flachsbart, Friederike; Ellinghaus, David; Gentschew, Liljana; Heinsen, Femke-Anouska; Caliebe, Amke; Christiansen, Lene; Nygaard, Marianne; Christensen, Kaare; Blanché, Hélène; Deleuze, Jean-François; Derbois, Céline; Galan, Pilar; Büning, Carsten; Brand, Stephan; Peters, Anette; Strauch, Konstantin; Müller-Nurasyid, Martina; Hoffmann, Per; Nöthen, Markus M; Lieb, Wolfgang; Franke, Andre; Schreiber, Stefan; Nebel, Almut

    2016-06-01

    Human longevity is characterized by a remarkable lack of confirmed genetic associations. Here, we report on the identification of a novel locus for longevity in the RAD50/IL13 region on chromosome 5q31.1 using a combined European sample of 3208 long-lived individuals (LLI) and 8919 younger controls. First, we performed a large-scale association study on 1458 German LLI (mean age 99.0 years) and 6368 controls (mean age 57.2 years) by targeting known immune-associated loci covered by the Immunochip. The analysis of 142 136 autosomal single nucleotide polymorphisms (SNPs) revealed an Immunochip-wide significant signal (PI mmunochip  = 7.01 × 10(-9) ) for the SNP rs2075650 in the TOMM40/APOE region, which has been previously described in the context of human longevity. To identify novel susceptibility loci, we selected 15 markers with PI mmunochip  association at SNP rs2706372 replicated in the French study collection and showed a similar trend in the Danish participants and was also significant in a meta-analysis of the combined French and Danish data after adjusting for multiple testing. In a meta-analysis of all three samples, rs2706372 reached a P-value of PI mmunochip+Repl  = 5.42 × 10(-7) (OR = 1.20; 95% CI = 1.12-1.28). SNP rs2706372 is located in the extended RAD50/IL13 region. RAD50 seems a plausible longevity candidate due to its involvement in DNA repair and inflammation. Further studies are needed to identify the functional variant(s) that predispose(s) to a long and healthy life. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  9. Altered regional homogeneity in the development of minimal hepatic encephalopathy: a resting-state functional MRI study.

    Directory of Open Access Journals (Sweden)

    Ling Ni

    Full Text Available BACKGROUND: Little is known about how spontaneous brain activity progresses from non-hepatic encephalopathy (non-HE to minimal HE (MHE. The purpose of this study was to evaluate the evolution pattern of spontaneous brain activities in cirrhotic patients using resting-state fMRI with a regional homogeneity (ReHo method. METHODOLOGY/PRINCIPAL FINDINGS: Resting-state fMRI data were acquired in 47 cirrhotic patients (minimal HE [MHE], n = 20, and non-HE, n = 27 and 25 age-and sex-matched healthy controls. The Kendall's coefficient of concordance (KCC was used to measure the regional homogeneity. The regional homogeneity maps were compared with ANOVA tests among MHE, non-HE, and healthy control groups and t-tests between each pair in a voxel-wise way. Correlation analyses were performed to explore the relationships between regional ReHo values and Child-Pugh scores, number connection test type A (NCT-A, digit symbol test (DST scores, venous blood ammonia levels. Compared with healthy controls, both MHE and non-HE patients showed decreased ReHo in the bilateral frontal, parietal and temporal lobes and increased ReHo in the bilateral caudate. Compared with the non-HE, MHE patients showed decreased ReHo in the bilateral precuneus, cuneus and supplementary motor area (SMA. The NCT-A of cirrhotic patients negatively correlated with ReHo values in the precuneus, cuneus and lingual gyrus. DST scores positively correlated with ReHo values in the cuneus, precuneus and lingual gyrus, and negatively correlated with ReHo values in the bilateral caudate (P<0.05, AlphaSim corrected. CONCLUSIONS/SIGNIFICANCE: Diffused abnormal homogeneity of baseline brain activity was nonspecific for MHE, and only the progressively decreased ReHo in the SMA and the cuneus, especially for the latter, might be associated with the development of MHE. The ReHo analysis may be potentially valuable for detecting the development from non-HE to MHE.

  10. Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS).

    Science.gov (United States)

    Huehne, Kathrin; Schaal, Ute; Leis, Stefan; Uebe, Steffen; Gosso, M Florencia; van den Maagdenberg, Arn M J M; Maihöfner, Christian; Birklein, Frank; Rautenstrauss, Bernd; Winterpacht, Andreas

    2010-03-12

    Complex regional pain syndrome (CRPS) is a condition that is characterized by severe pain and exaggerated neurogenic inflammation, which may develop after injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) that are released from nociceptors. Genetic factors may play a role in CRPS as was suggested by the occurrence of familial cases and several genetic association studies investigating mainly the human leukocyte antigen (HLA) system. Here we investigated the role of neutral endopeptidase (NEP), a key enzyme in neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of neuropeptides may be a possible pathomechanism in CRPS. To this end, we tested a GT-repeat polymorphism in the NEP promoter region as well as 18 tag-SNPs in six linkage disequilibrium (LD) blocks in the NEP gene region in 320 CRPS patients and 376 controls. No significant genetic association was observed. Thus, we conclude that the NEP gene does not seem to be a major risk factor for CRPS. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  11. [Maternal hemoglobin in Peru: regional differences and its association with adverse perinatal outcomes].

    Science.gov (United States)

    Gonzales, Gustavo F; Tapia, Vilma; Gasco, Manuel; Carrillo, Carlos

    2011-01-01

    To evaluate hemoglobin (Hb) levels in pregnant women from different geographical regions from Peru; to establish anemia and erythrocytocis rates and to establish the role of Hb on adverse perinatal outcomes using the Perinatal Information System (PIS) database of Peruvian Ministry of Health. Data were obtained from 379,816 births of 43 maternity care units between 2000 and 2010. Anemia and erythrocytocis rates were determined in each geographical region as well as rates of adverse perinatal outcomes. To analyze data the STATA program (versión 10.0,Texas, USA) was used. The results were considered significant at panemia rate was higher in the coast (25.8%) and low forest (26.2%). Moderate/severe anemia rate in low forest was 2.6% and at the coast was 1.0%. In the highland, the highest rate of moderate/severe anemia was in the southern highlands (0.6%). The highest rate of erythrocytocis was found in the central highland (23.7%), 11.9% in the southern highland and 9.5% in the north highland. Severe anemia and erythrocytocis were associated with adverse perinatal outcomes. There are differences by Peruvian geographical region in anemia rates. In the central highlands were found the highest rates of erythrocytocis due to hypoxia effect in the high altitudes; however in the southern highlands, erythrocytocis was lower. Severe anemia and erythrocytosis were associated with increased adverse perinatal outcomes.

  12. Prevalence, Clinical Presentation, and Factors Associated With Diabetic Foot Ulcer in Two Regional Hospitals in Cameroon.

    Science.gov (United States)

    Tindong, Maxime; Palle, John N; Nebongo, Daniel; Aminde, Leopold Ndemnge; Mboue-Djieka, Yannick; Mbarga, Nicole T Fouda; Dehayem, Mesmin Y; Choukem, Siméon-Pierre

    2018-03-01

    This study aimed to determine the prevalence of diabetic foot ulcer and high risk for ulceration, describe the clinical presentation, and identify factors associated with diabetic foot ulcer in the Southwest regional hospitals of Cameroon. In this cross-sectional study, data were collected using a structured questionnaire administered to consecutive patients with diabetes. Findings from detailed foot examination were recorded. Diabetic foot ulcer was diagnosed according to the International Working Group on Diabetic Foot (IWGDF) definition. Data were analyzed with Stata IC version 12. Of the 203 participants included, 63.1% were females. Age ranged from 26 to 96 years. The median duration of diabetes was 4.0 years (interquartile range 1.0-8.0 years). The prevalence of diabetic foot ulcer was 11.8% (24), of whom 29.2% (7) had high grade (grades 2 to 4), and most of the ulcers 58.3% (14) were located at the plantar region. The prevalence of high risk for ulceration was 21.8% (39). Loss of protective sensation (OR = 3.73, 95% CI = 1.43-9.71; P = .007), and peripheral arterial disease (OR = 3.48, 95% CI = 1.14-10.56; P = .028) were independently associated with diabetic foot. Diabetic foot ulcer is a common complication among patients with diabetes attending these regional hospitals. Loss of protective sensation, and peripheral arterial disease increase the odds of having diabetic foot ulcer, and we suggest them as the main target of interest for prevention.

  13. Abundância e sazonalidade de histerídeos (Coleoptera associados ao esterco de granja aviária da Região Nordeste do Estado de São Paulo, Brasil Abundance and seasonality of Histeridae (Coleoptera associated to brooding hen excrement in the northeast region of the state of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Welber Daniel Zanetti Lopes

    2006-12-01

    Full Text Available Programas que visam o controle biológico precisam ser embasados principalmente em liberações de predadores e parasitóides para tentar minimizar efeitos adversos para o ambiente. Os coleópteros da família Histeridae como predam larvas de dípteros sinantrópicos podem auxiliar no controle das moscas que se desenvolvem em fezes acumuladas. Este trabalho teve como objetivo realizar um levantamento das espécies de histerídeos em granja avícola no município de São João da Boa Vista, estado de São Paulo, verificar seu padrão sazonal de ocorrência e investigar possíveis associações entre as mesmas. As coletas foram realizadas de janeiro de 2001 a dezembro de 2002, utilizando-se dois métodos de coleta (armadilhas de solo e o funil de Berlese - Tullgren. As espécies de histerídeos encontradas foram: Euspilostus modestus, Euspilostus (Hesperosaprinus spp., Carcinops troglodytes e Hololepta quadridentata. O número de cada espécie diferiu entre os métodos utilizados. Na armadilha de solo, E. modestus correspondeu a 87,01% do número total de indivíduos capturados, enquanto que no funil, C. troglodytes obteve maior destaque (84,38%. E. modestus e H. quadridentata apresentaram padrões de variação mensal positivamente correlacionada com a precipitação pluviométrica (PPrograms for biological control are usually based on the release of predators and parasites so that no hazard is posed to the natural environment. Coleoptera of the Histeridae family feed on the larvae of synantropic diptera, enabling their use in the control of such flies. The objective of this work was to carry out a survey of the Histeridae species present at a poultry house situated in the city of São João da Boa Vista, state of São Paulo, Brazil, aiming to describe their seasonality and the possible associations between the adult specimens. Samples were collected from the poultry houses from January 2001 to December 2002, using two collection methods: soil

  14. Ethnobotany of medicinal plants in Ada'a District, East Shewa Zone of Oromia Regional State, Ethiopia.

    Science.gov (United States)

    Kefalew, Alemayehu; Asfaw, Zemede; Kelbessa, Ensermu

    2015-04-02

    An ethnobotanical study of medicinal plants was conducted in Ada'a District, Eastern Shewa Zone of Oromia Regional State of Ethiopia. The objective of the study was to identify and document medicinal plants and the associated ethnobotanical/ethnomedicinal knowledge of the local people. Relevant ethnobotanical data focused on medicinal plants and traditional herbal medicines were collected using guided field walk, semi-structured interview and direct field observation. Informant consensus method and group discussion were conducted for crosschecking and verification of the information. Both descriptive statistics and quantitative ethnobotanical methods were used for data analysis. We documented 131 species distributed in 109 genera and 54 families based on local claims of medicinal values. Patients who are using traditional drugs and herbalists collect most of these plants from the wild. The leading plant families that encompass large medicinal species were the Lamiaceae (14 species) followed by Asteraceae (13) and Solanaceae (7). The study reported the existence of a number of medicinal plants, an indication for the presence of plant-based traditional medicinal knowledge transfer that survived through generations. Informants asserted that wild growing medicinal plants are under threat due to increased use pressure coupled with unsuitable harvesting that frequently targets roots and barks for remedy preparations. This calls for urgent and collaborative actions to keep the balance between medicinal plants availability in the wild state and their utilization by the community. Furthermore, the study attempted to prioritize the most efficacious medicinal plants as perceived by the local people for possible pharmacological testing.

  15. In search of Archean basement from Rio Maria region, southeastern of Para State

    International Nuclear Information System (INIS)

    Macambira, M.B.; Lancelot, J.

    1991-01-01

    The Rio Maria Region, southeastern part of the Amazonian craton (Brazil), displays a typical Archaean granite-greenstone association intruded by Proterozoic granites. The greenstone is crosscut by Archaean granitoids, such as the Rio Maria granodiorite. Clear field contacts between the Xingu gneisses and the granodiorite are lacking, making it difficult to determine the stratigraphic sequence. U-Pb data for zircons from the Xingu gneiss and the Rio Maria granodiorite provide upper intercept ages of 2971 +30/ -28 Ma and 2874 +9/ -10 Ma respectively on the Concordia diagram. 2.97 Ga is the most ancient age ever obtained on zircons from gneisses of the Amazonian craton. It provides an upper limit for the beginning of the continental crust formation in this part of the craton. (author)

  16. Investigation of QTL regions on Chromosome 17 for genes associated with meat color in the pig.

    Science.gov (United States)

    Fan, B; Glenn, K L; Geiger, B; Mileham, A; Rothschild, M F

    2008-08-01

    Previous studies have uncovered several significant quantitative trait loci (QTL) relevant to meat colour traits mapped at the end of SSC17 in the pig. Furthermore, results released from the porcine genome sequencing project have identified genes underlying the entire QTL regions and can further contribute to mining the region for likely causative genes. Ten protein coding genes or novel transcripts located within the QTL regions were screened for single nucleotide polymorphisms (SNPs). Linkage mapping and association studies were carried out in the ISU Berkshire x Yorkshire (B x Y) pig resource family. The total length of the new SSC17 linkage map was 126.6 cM and additional markers including endothelin 3 (EDN3) and phosphatase and actin regulator 3 (PHACTR3) genes were assigned at positions 119.4 cM and 122.9 cM, respectively. A new QTL peak was noted at approximately 120 cM, close to the EDN3 gene, and for some colour traits QTL exceeded the 5% chromosome-wise significance threshold. The association analyses in the B x Y family showed that the EDN3 BslI and PHACTR3 PstI polymorphisms were strongly associated with the subjective colour score and objective colour reflectance measures in the loin, as well as average drip loss percentage and pH value. The RNPC1 DpnII and CTCFL HpyCH4III polymorphisms were associated with some meat colour traits. No significant association between CBLN4, TFAP2C, and four novel transcripts and meat colour traits were detected. The association analyses conducted in one commercial pig line found that both EDN3 BslI and PHACTR3 PstI polymorphisms were associated with meat colour reflectance traits such as centre loin hue angle and Minolta Lightness score. The present findings suggested that the EDN3 and PHACTR3 genes might have potential effects on meat colour in pigs, and molecular mechanisms of their functions are worth exploring.

  17. Associations between accelerated glacier mass wastage and increased summer temperature in coastal regions

    Science.gov (United States)

    Dyurgerov, M.; McCabe, G.J.

    2006-01-01

    Low-elevation glaciers in coastal regions of Alaska, the Canadian Arctic, individual ice caps around the Greenland ice sheet, and the Patagonia Ice Fields have an aggregate glacier area of about 332 ?? 103 km 2 and account for approximately 42% of all the glacier area outside the Greenland and Antarctic ice sheets. They have shown volume loss, especially since the end of the 1980s, increasing from about 45% in the 1960s to nearly 67% in 2003 of the total wastage from all glaciers on Earth outside those two largest ice sheets. Thus, a disproportionally large contribution of coastal glacier ablation to sea level rise is evident. We examine cumulative standardized departures (1961-2000 reference period) of glacier mass balances and air temperature data in these four coastal regions. Analyses indicate a strong association between increases in glacier volume losses and summer air temperature at regional and global scales. Increases in glacier volume losses in the coastal regions also coincide with an accelerated rate of ice discharge from outlet glaciers draining the Greenland and West Antarctic ice sheets. These processes imply further increases in sea level rise. ?? 2006 Regents of the University of Colorado.

  18. Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia

    Directory of Open Access Journals (Sweden)

    R. Walter Heinrichs

    2017-01-01

    Full Text Available This study assessed whether cortical thickness across the brain and regionally in terms of the default mode, salience, and central executive networks differentiates schizophrenia patients and healthy controls with normal range or below-normal range cognitive performance. Cognitive normality was defined using the MATRICS Consensus Cognitive Battery (MCCB composite score (T=50 ± 10 and structural magnetic resonance imaging was used to generate cortical thickness data. Whole brain analysis revealed that cognitively normal range controls (n=39 had greater cortical thickness than both cognitively normal (n=17 and below-normal range (n=49 patients. Cognitively normal controls also demonstrated greater thickness than patients in regions associated with the default mode and salience, but not central executive networks. No differences on any thickness measure were found between cognitively normal range and below-normal range controls (n=24 or between cognitively normal and below-normal range patients. In addition, structural covariance between network regions was high and similar across subgroups. Positive and negative symptom severity did not correlate with thickness values. Cortical thinning across the brain and regionally in relation to the default and salience networks may index shared aspects of the psychotic psychopathology that defines schizophrenia with no relation to cognitive impairment.

  19. Wave like signatures in aerosol optical depth and associated radiative impacts over the central Himalayan region

    Energy Technology Data Exchange (ETDEWEB)

    Shukla, K. K.; Phanikumar, D. V.; Kumar, K.  Niranjan; Reddy, Kishore; Kotamarthi, V. R.; Newsom, Rob K.; Ouarda, Taha B. M. J.

    2015-10-01

    In this study, we present a case study on 16 October 2011 to show the first observational evidence of the influence of short period gravity waves in aerosol transport during daytime over the central Himalayan region. The Doppler lidar data has been utilized to address the daytime boundary layer evolution and related aerosol dynamics over the site. Mixing layer height is estimated by wavelet covariance transform method and found to be ~ 0.7 km, AGL. Aerosol optical depth observations during daytime revealed an asymmetry showing clear enhancement during afternoon hours as compared to forenoon. Interestingly, Fourier and wavelet analysis of vertical velocity and attenuated backscatter showed similar 50-90 min short period gravity wave signatures during afternoon hours. Moreover, our observations showed that gravity waves are dominant within the boundary layer implying that the daytime boundary layer dynamics is playing a vital role in transporting the aerosols from surface to the top of the boundary layer. Similar modulations are also evident in surface parameters like temperature, relative humidity and wind speed indicating these waves are associated with the dynamical aspects over Himalayan region. Finally, time evolution of range-23 height indicator snapshots during daytime showed strong upward velocities especially during afternoon hours implying that convective processes through short period gravity waves plays a significant role in transporting aerosols from the nearby valley region to boundary layer top over the site. These observations also establish the importance of wave induced daytime convective boundary layer dynamics in the lower Himalayan region.

  20. Regional Information Group (RIG). Energy, environmental, and socioeconomic data bases and associated software at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Loebl, A.S.; Malthouse, N.S.; Shonka, D.B.; Ogle, M.C.; Johnson, M.L.

    1976-10-01

    A machine readable data base has been created by the Regional Information Group, Regional and Urban Studies Section, Energy Division, Oak Ridge National Laboratory, to provide documentation for the energy, environmental, and socioeconomic data bases and associated software maintained at Oak Ridge National Laboratory. This document is produced yearly by the Regional Information Group to describe the contents and organization of this data base.

  1. Regional Information Group (RIG). Energy, environmental, and socioeconomic data bases and associated software at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Loebl, A.S.; Malthouse, N.S.; Shonka, D.B.; Ogle, M.C.; Johnson, M.L.

    1976-10-01

    A machine readable data base has been created by the Regional Information Group, Regional and Urban Studies Section, Energy Division, Oak Ridge National Laboratory, to provide documentation for the energy, environmental, and socioeconomic data bases and associated software maintained at Oak Ridge National Laboratory. This document is produced yearly by the Regional Information Group to describe the contents and organization of this data base

  2. 36 CFR 271.8 - Consultation with Association of State Foresters and the Advertising Council.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Consultation with Association of State Foresters and the Advertising Council. 271.8 Section 271.8 Parks, Forests, and Public... Association of State Foresters and the Advertising Council. These regulations in this part have been issued...

  3. Life-history strategies associated with local population variability confer regional stability.

    Science.gov (United States)

    Pribil, Stanislav; Houlahan, Jeff E

    2003-07-07

    A widely held ecological tenet is that, at the local scale, populations of K-selected species (i.e. low fecundity, long lifespan and large body size) will be less variable than populations of r-selected species (i.e. high fecundity, short lifespan and small body size). We examined the relationship between long-term population trends and life-history attributes for 185 bird species in the Czech Republic and found that, at regional spatial scales and over moderate temporal scales (100-120 years), K-selected bird species were more likely to show both large increases and decreases in population size than r-selected species. We conclude that life-history attributes commonly associated with variable populations at the local scale, confer stability at the regional scale.

  4. Association of genetic variations in the mitochondrial DNA control region with presbycusis

    Directory of Open Access Journals (Sweden)

    Falah M

    2017-03-01

    Full Text Available Masoumeh Falah,1 Mohammad Farhadi,1 Seyed Kamran Kamrava,1 Saeid Mahmoudian,1 Ahmad Daneshi,1 Maryam Balali,1 Alimohamad Asghari,2 Massoud Houshmand1,3 1ENT and Head & Neck Research Center and Department, Iran University of Medical Sciences, Tehran, Iran; 2Skull Base Research Center, Iran University of Medical Sciences, Tehran, Iran; 3Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Background: The prominent role of mitochondria in the generation of reactive oxygen species, cell death, and energy production contributes to the importance of this organelle in the intracellular mechanism underlying the progression of the common sensory disorder of the elderly, presbycusis. Reduced mitochondrial DNA (mtDNA gene expression and coding region variation have frequently been reported as being associated with the development of presbycusis. The mtDNA control region regulates gene expression and replication of the genome of this organelle. To comprehensively understand of the role of mitochondria in the progression of presbycusis, we compared variations in the mtDNA control region between subjects with presbycusis and controls.Methods: A total of 58 presbycusis patients and 220 control subjects were enrolled in the study after examination by the otolaryngologist and audiology tests. Variations in the mtDNA control region were investigated by polymerase chain reaction and Sanger sequencing.Results: A total of 113 sequence variants were observed in mtDNA, and variants were detected in 100% of patients, with 84% located in hypervariable regions. The frequencies of the variants, 16,223 C>T, 16,311 T>C, 16,249 T>C, and 15,954 A>C, were significantly different between presbycusis and control subjects.Conclusion: The statistically significant difference in the frequencies of four nucleotide variants in the mtDNA control region of presbycusis patients and controls is in agreement with previous experimental

  5. Altered frontal inter-hemispheric resting state functional connectivity is associated with bulimic symptoms among restrained eaters.

    Science.gov (United States)

    Chen, Shuaiyu; Dong, Debo; Jackson, Todd; Su, Yanhua; Chen, Hong

    2016-01-29

    Theory and research have indicated that restrained eating (RE) increases risk for binge-eating and eating disorder symptoms. According to the goal conflict model, such risk may result from disrupted hedonic-feeding control and its interaction with reward-driven eating. However, RE-related alterations in functional interactions among associated underlying brain regions, especially between the cerebral hemispheres, have rarely been examined directly. Therefore, we investigated inter-hemispheric resting-state functional connectivity (RSFC) among female restrained eaters (REs) (n=23) and unrestrained eaters (UREs) (n=24) following food deprivation as well as its relation to overall bulimia nervosa (BN) symptoms using voxel-mirrored homotopic connectivity (VMHC). Seed-based RSFC associated with areas exhibiting significant VMHC differences was also assessed. Compared to UREs, REs showed reduced VMHC in the dorsal-lateral prefrontal cortex (DLPFC), an area involved in inhibiting hedonic overeating. REs also displayed decreased RSFC between the right DLPFC and regions associated with reward estimation--the ventromedial prefrontal cortex (VMPFC) and posterior cingulate cortex (PCC). Finally, bulimic tendencies had a negative correlation with VMHC in the DLPFC and a positive correlation with functional connectivity (DLPFC and VMPFC) among REs but not UREs. Findings suggested that reduced inter-hemispheric functional connectivity in appetite inhibition regions and altered functional connectivity in reward related regions may help to explain why some REs fail to control hedonically-motivated feeding and experience higher associated levels of BN symptomatology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. DNA methylation in the APOE genomic region is associated with cognitive function in African Americans.

    Science.gov (United States)

    Liu, Jiaxuan; Zhao, Wei; Ware, Erin B; Turner, Stephen T; Mosley, Thomas H; Smith, Jennifer A

    2018-05-08

    Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expression. Recent studies have found evidence that DNA methylation may contribute to the pathogenesis of dementia, but its association with cognitive function in populations without dementia remains unclear. We assessed DNA methylation levels of 48 CpG sites in the APOE genomic region in peripheral blood leukocytes collected from 289 African Americans (mean age = 67 years) from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Using linear regression, we examined the relationship between methylation in the APOE genomic region and multiple cognitive measures including learning, memory, processing speed, concentration, language and global cognitive function. We identified eight CpG sites in three genes (PVRL2, TOMM40, and APOE) that showed an inverse association between methylation level and delayed recall, a measure of memory, after adjusting for age and sex (False Discovery Rate q-value accounting for known genetic predictors for cognition. Our findings highlight the important role of epigenetic mechanisms in influencing cognitive performance, and suggest that changes in blood methylation may be an early indicator of individuals at risk for dementia as well as potential targets for intervention in asymptomatic populations.

  7. Harsh corporal punishment is associated with increased T2 relaxation time in dopamine-rich regions.

    Science.gov (United States)

    Sheu, Yi-Shin; Polcari, Ann; Anderson, Carl M; Teicher, Martin H

    2010-11-01

    Harsh corporal punishment (HCP) was defined as frequent parental administration of corporal punishment (CP) for discipline, with occasional use of objects such as straps, or paddles. CP is linked to increased risk for depression and substance abuse. We examine whether long-term exposure to HCP acts as sub-traumatic stressor that contributes to brain alterations, particularly in dopaminergic pathways, which may mediate their increased vulnerability to drug and alcohol abuse. Nineteen young adults who experienced early HCP but no other forms of maltreatment and twenty-three comparable controls were studied. T2 relaxation time (T2-RT) measurements were performed with an echo planar imaging TE stepping technique and T2 maps were calculated and analyzed voxel-by-voxel to locate regional T2-RT differences between groups. Previous studies indicated that T2-RT provides an indirect index of resting cerebral blood volume. Region of interest (ROI) analyses were also conducted in caudate, putamen, nucleus accumbens, anterior cingulate cortex, dorsolateral prefrontal cortex, thalamus, globus pallidus and cerebellar hemispheres. Voxel-based relaxometry showed that HCP was associated with increased T2-RT in right caudate and putamen. ROI analyses also revealed increased T2-RT in dorsolateral prefrontal cortex, substantia nigra, thalamus and accumbens but not globus pallidus or cerebellum. There were significant associations between T2-RT measures in dopamine target regions and use of drugs and alcohol, and memory performance. Alteration in the paramagnetic or hemodynamic properties of dopaminergic cell body and projection regions were observed in subjects with HCP, and these findings may relate to their increased risk for drug and alcohol abuse. Copyright 2010 Elsevier Inc. All rights reserved.

  8. Productivity losses associated with tuberculosis deaths in the World Health Organization African region.

    Science.gov (United States)

    Kirigia, Joses Muthuri; Muthuri, Rosenabi Deborah Karimi

    2016-06-01

    In 2014, almost half of the global tuberculosis deaths occurred in the World Health Organization (WHO) African Region. Approximately 21.5 % of the 6 060 742 TB cases (new and relapse) reported to the WHO in 2014 were in the African Region. The specific objective of this study was to estimate future gross domestic product (GDP) losses associated with TB deaths in the African Region for use in advocating for better strategies to prevent and control tuberculosis. The cost-of-illness method was used to estimate non-health GDP losses associated with TB deaths. Future non-health GDP losses were discounted at 3 %. The analysis was conducted for three income groups of countries. One-way sensitivity analysis at 5 and 10 % discount rates was undertaken to assess the impact on the expected non-health GDP loss. The 0.753 million tuberculosis deaths that occurred in the African Region in 2014 would be expected to decrease the future non-health GDP by International Dollars (Int$) 50.4 billion. Nearly 40.8, 46.7 and 12.5 % of that loss would come from high and upper-middle- countries or lower-middle- and low-income countries, respectively. The average total non-health GDP loss would be Int$66 872 per tuberculosis death. The average non-health GDP loss per TB death was Int$167 592 for Group 1, Int$69 808 for Group 2 and Int$21 513 for Group 3. Tuberculosis exerts a sizeable economic burden on the economies of the WHO AFR countries. This implies the need to strongly advocate for better strategies to prevent and control tuberculosis and to help countries end the epidemic of tuberculosis by 2030, as envisioned in the United Nations General Assembly resolution on Sustainable Development Goals (SDGs).

  9. Meteorological aspects associated with dust storms in the Sistan region, southeastern Iran

    Science.gov (United States)

    Kaskaoutis, D. G.; Rashki, A.; Houssos, E. E.; Mofidi, A.; Goto, D.; Bartzokas, A.; Francois, P.; Legrand, M.

    2015-07-01

    Dust storms are considered natural hazards that seriously affect atmospheric conditions, ecosystems and human health. A key requirement for investigating the dust life cycle is the analysis of the meteorological (synoptic and dynamic) processes that control dust emission, uplift and transport. The present work focuses on examining the synoptic and dynamic meteorological conditions associated with dust-storms in the Sistan region, southeastern Iran during the summer season (June-September) of the years 2001-2012. The dust-storm days (total number of 356) are related to visibility records below 1 km at Zabol meteorological station, located near to the dust source. RegCM4 model simulations indicate that the intense northern Levar wind, the high surface heating and the valley-like characteristics of the region strongly affect the meteorological dynamics and the formation of a low-level jet that are strongly linked with dust exposures. The intra-annual evolution of the dust storms does not seem to be significantly associated with El-Nino Southern Oscillation, despite the fact that most of the dust-storms are related to positive values of Oceanic Nino Index. National Center for Environmental Prediction/National Center for Atmospheric Research reanalysis suggests that the dust storms are associated with low sea-level pressure conditions over the whole south Asia, while at 700 hPa level a trough of low geopotential heights over India along with a ridge over Arabia and central Iran is the common scenario. A significant finding is that the dust storms over Sistan are found to be associated with a pronounced increase of the anticyclone over the Caspian Sea, enhancing the west-to-east pressure gradient and, therefore, the blowing of Levar. Infrared Difference Dust Index values highlight the intensity of the Sistan dust storms, while the SPRINTARS model simulates the dust loading and concentration reasonably well, since the dust storms are usually associated with peaks in model

  10. Analytic continuation of scattering data to the region of negative energies for systems that have one and two bound states

    International Nuclear Information System (INIS)

    Blokhintsev, L. D.; Savin, D. A.

    2016-01-01

    An exactly solvable potential model is used to study the possibility of deducing information about the features of bound states for the system under consideration (binding energies and asymptotic normalization coefficients) on the basis of data on continuum states. The present analysis is based on an analytic approximation and on the subsequent continuation of a partial-wave scattering function from the region of positive energies to the region of negative energies. Cases where the system has one or two bound states are studied. The α+d and α+"1"2C systems are taken as physical examples. In the case of one bound state, the scattering function is a smooth function of energy, and the procedure of its analytic continuation for different polynomial approximations leads to close results, which are nearly coincident with exact values. In the case of two bound states, the scattering function has two poles—one in the region of positive energies and the other in the region of negative energies between the energies corresponding to the two bound states in question. Padéapproximants are used to reproduce these poles. The inclusion of these poles proves to be necessary for correctly describing the properties of the bound states.

  11. Structural covariance of brain region volumes is associated with both structural connectivity and transcriptomic similarity.

    Science.gov (United States)

    Yee, Yohan; Fernandes, Darren J; French, Leon; Ellegood, Jacob; Cahill, Lindsay S; Vousden, Dulcie A; Spencer Noakes, Leigh; Scholz, Jan; van Eede, Matthijs C; Nieman, Brian J; Sled, John G; Lerch, Jason P

    2018-05-18

    An organizational pattern seen in the brain, termed structural covariance, is the statistical association of pairs of brain regions in their anatomical properties. These associations, measured across a population as covariances or correlations usually in cortical thickness or volume, are thought to reflect genetic and environmental underpinnings. Here, we examine the biological basis of structural volume covariance in the mouse brain. We first examined large scale associations between brain region volumes using an atlas-based approach that parcellated the entire mouse brain into 318 regions over which correlations in volume were assessed, for volumes obtained from 153 mouse brain images via high-resolution MRI. We then used a seed-based approach and determined, for 108 different seed regions across the brain and using mouse gene expression and connectivity data from the Allen Institute for Brain Science, the variation in structural covariance data that could be explained by distance to seed, transcriptomic similarity to seed, and connectivity to seed. We found that overall, correlations in structure volumes hierarchically clustered into distinct anatomical systems, similar to findings from other studies and similar to other types of networks in the brain, including structural connectivity and transcriptomic similarity networks. Across seeds, this structural covariance was significantly explained by distance (17% of the variation, up to a maximum of 49% for structural covariance to the visceral area of the cortex), transcriptomic similarity (13% of the variation, up to maximum of 28% for structural covariance to the primary visual area) and connectivity (15% of the variation, up to a maximum of 36% for structural covariance to the intermediate reticular nucleus in the medulla) of covarying structures. Together, distance, connectivity, and transcriptomic similarity explained 37% of structural covariance, up to a maximum of 63% for structural covariance to the

  12. Natural selection among Eurasians at genomic regions associated with HIV-1 control

    Directory of Open Access Journals (Sweden)

    Allison David B

    2011-06-01

    Full Text Available Abstract Background HIV susceptibility and pathogenicity exhibit both interindividual and intergroup variability. The etiology of intergroup variability is still poorly understood, and could be partly linked to genetic differences among racial/ethnic groups. These genetic differences may be traceable to different regimes of natural selection in the 60,000 years since the human radiation out of Africa. Here, we examine population differentiation and haplotype patterns at several loci identified through genome-wide association studies on HIV-1 control, as determined by viral-load setpoint, in European and African-American populations. We use genome-wide data from the Human Genome Diversity Project, consisting of 53 world-wide populations, to compare measures of FST and relative extended haplotype homozygosity (REHH at these candidate loci to the rest of the respective chromosome. Results We find that the Europe-Middle East and Europe-South Asia pairwise FST in the most strongly associated region are elevated compared to most pairwise comparisons with the sub-Saharan African group, which exhibit very low FST. We also find genetic signatures of recent positive selection (higher REHH at these associated regions among all groups except for sub-Saharan Africans and Native Americans. This pattern is consistent with one in which genetic differentiation, possibly due to diversifying/positive selection, occurred at these loci among Eurasians. Conclusions These findings are concordant with those from earlier studies suggesting recent evolutionary change at immunity-related genomic regions among Europeans, and shed light on the potential genetic and evolutionary origin of population differences in HIV-1 control.

  13. Is Living near Healthier Food Stores Associated with Better Food Intake in Regional Australia?

    Science.gov (United States)

    Moayyed, Hamid; Kelly, Bridget; Feng, Xiaoqi; Flood, Victoria

    2017-08-07

    High prevalence of obesity and non-communicable diseases is a global public health problem, in which the quality of food environments is thought to play an important role. Current scientific evidence is not consistent regarding the impact of food environments on diet. The relationship between local food environments and diet quality was assessed across 10 Australian suburbs, using Australian-based indices devised to measure the two parameters. Data of dietary habits from the participants was gathered using a short questionnaire. The suburbs' Food Environment Score (higher being healthier) was associated with higher consumption of fruit (χ² (40, 230) = 58.8, p = 0.04), and vegetables (χ² (40, 230) = 81.3, p = 0.03). The Food Environment Score identified a significant positive correlation with four of the diet scores: individual total diet score (r s = 0.30, p food score (r s = 0.15, p Food Environment Index, higher being unhealthier) showed a significant association with higher consumption of salty snacks (χ² (24, 230) = 43.9, p = 0.04). Food environments dominated by food outlets considered as 'healthier' were associated with healthier population food intakes, as indicated by a higher consumption of fruit, vegetables, and water, as well as a lower consumption of junk food, salty snacks, and sugary drinks. This association suggests that healthier diet quality is associated with healthier food environments in regional Australia.

  14. Soils Developed on Geomorphic Surfaces in the Mountain Region of the State of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Ademir Fontana

    2018-01-01

    Full Text Available ABSTRACT: The evaluation of soils in representative landscapes constitutes an opportunity to evaluate spatial distribution, discuss formation processes, and apply this knowledge to land use and management. In this sense, from the perspective of an environmentally diversified region, the aim of the present study is to evaluate the occurrence and understand the formation of soils in different geomorphic surfaces of a landscape from a mountain region in the state of Rio de Janeiro. The study was developed in the Pito Aceso microbasin in the municipality of Bom Jardim, composed of narrow valleys and a rugged mountain domain, with elevation between 640 and 1,270 m. In a representative landscape, the geomorphic surfaces were obtained from the slope segments and flow lines. On the geomorphic surfaces, soil profiles were described by their morphological properties, collected, and analyzed to describe the chemical and physical properties of each horizon. Geomorphological aspects and possible variations of the parent material directly affected pedogenesis and led to distinct soil classes in the landscape. Variation in the geomorphic surfaces directs the processes for soil formation under current conditions, as well as the preservation of polygenetic soils. Soils of lower development and with greater participation of the exchangeable cations were identified at the summit (talus deposit (Neossolo Litólico and Cambissolo Húmico and toeslope (colluvial-alluvial (Neossolo Flúvico, whereas more developed soils with lower nutrient content occur in the concave (Argissolos Vermelho and Amarelo and convex (Latossolo Amarelo backslope, except for the Argissolo Vermelho-Amarelo in the shoulder, which had high exchangeable cations contents.

  15. Quantifying the sources of ozone, fine particulate matter, and regional haze in the Southeastern United States.

    Science.gov (United States)

    Odman, M Talat; Hu, Yongtao; Russell, Armistead G; Hanedar, Asude; Boylan, James W; Brewer, Patricia F

    2009-07-01

    A detailed sensitivity analysis was conducted to quantify the contributions of various emission sources to ozone (O3), fine particulate matter (PM2.5), and regional haze in the Southeastern United States. O3 and particulate matter (PM) levels were estimated using the Community Multiscale Air Quality (CMAQ) modeling system and light extinction values were calculated from modeled PM concentrations. First, the base case was established using the emission projections for the year 2009. Then, in each model run, SO2, primary carbon (PC), NH3, NO(x) or VOC emissions from a particular source category in a certain geographic area were reduced by 30% and the responses were determined by calculating the difference between the results of the reduced emission case and the base case. The sensitivity of summertime O3 to VOC emissions is small in the Southeast and ground-level NO(x) controls are generally more beneficial than elevated NO(x) controls (per unit mass of emissions reduced). SO2 emission reduction is the most beneficial control strategy in reducing summertime PM2.5 levels and improving visibility in the Southeast and electric generating utilities are the single largest source of SO2. Controlling PC emissions can be very effective locally, especially in winter. Reducing NH3 emissions is an effective strategy to reduce wintertime ammonium nitrate (NO3NH4) levels and improve visibility; NO(x) emissions reductions are not as effective. The results presented here will help the development of specific emission control strategies for future attainment of the National Ambient Air Quality Standards in the region.

  16. Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity - United States, 2005-2014.

    Science.gov (United States)

    Steele, C Brooke; Thomas, Cheryll C; Henley, S Jane; Massetti, Greta M; Galuska, Deborah A; Agurs-Collins, Tanya; Puckett, Mary; Richardson, Lisa C

    2017-10-03

    Overweight and obesity are associated with increased risk of at least 13 different types of cancer. Data from the United States Cancer Statistics for 2014 were used to assess incidence rates, and data from 2005 to 2014 were used to assess trends for cancers associated with overweight and obesity (adenocarcinoma of the esophagus; cancers of the breast [in postmenopausal women], colon and rectum, endometrium, gallbladder, gastric cardia, kidney, liver, ovary, pancreas, and thyroid; meningioma; and multiple myeloma) by sex, age, race/ethnicity, state, geographic region, and cancer site. Because screening for colorectal cancer can reduce colorectal cancer incidence through detection of precancerous polyps before they become cancerous, trends with and without colorectal cancer were analyzed. In 2014, approximately 631,000 persons in the United States received a diagnosis of a cancer associated with overweight and obesity, representing 40% of all cancers diagnosed. Overweight- and obesity-related cancer incidence rates were higher among older persons (ages ≥50 years) than younger persons; higher among females than males; and higher among non-Hispanic black and non-Hispanic white adults compared with other groups. Incidence rates for overweight- and obesity-related cancers during 2005-2014 varied by age, cancer site, and state. Excluding colorectal cancer, incidence rates increased significantly among persons aged 20-74 years; decreased among those aged ≥75 years; increased in 32 states; and were stable in 16 states and the District of Columbia. The burden of overweight- and obesity-related cancer is high in the United States. Incidence rates of overweight- and obesity-related cancers except colorectal cancer have increased in some age groups and states. The burden of overweight- and obesity-related cancers might be reduced through efforts to prevent and control overweight and obesity. Comprehensive cancer control strategies, including use of evidence

  17. Factors associated with psychosocial services in ogun state, Nigeria

    Directory of Open Access Journals (Sweden)

    Olorunfemi Emmanuel Amoran

    2013-01-01

    Full Text Available Background: Belonging to a social network group may influence a person′s decisions to engage in desired behavior. Aim: The objective of our study was to determine factors associated with utilization of psychosocial group services among people living with human immunodeficiency virus acquired immunodeficiency syndrome (PLWHAs in a Teaching Hospital in Sagamu, Southwestern Nigeria. Settings and Design: This was an analytical cross-sectional study. All consenting PLHAs who attended the anti-retroviral clinic (ART clinic during the study period were recruited into the study. Materials and Methods: A structured self-administered questionnaire was used to collect relevant information and a total of 205 PLWHAs were interviewed. Statistical Analysis Used: The data analysis focused on univariate frequency table and bivariate cross tabulations that identify important relationships between the variables. Odds ratio (OR at 95% confidence level (CI and Chi-squared and t-tests were also computed. Results: The overall point utilization of psychosocial services among the PLWHAs was 23.4%. Utilization of psychosocial services was statistically significantly associated with religion (χ2 = 11.74, P = 0.003, disclosure of human immunodeficiency virus status (χ2 = 9.18, P = 0.01 and satisfactory self-reported health-related quality-of-life (HRQOL (χ2 = 5.67, P = 0.017 while sex (χ2 = 0.02, P = 0.96, education (χ2 = 4.67, P = 0.32 tribe (χ2 = 1.46, P = 0.48 adherence to ART drugs (χ2 = 0.44, P = 0.51, mental health status (χ2 = 0.64, P = 0.42 and occupation (χ2 = 3.61, P = 0.61 were not. The only predictor of utilization of psychosocial group services was religion (OR = 0.44, CI = 0.23-0.84. Conclusion: This study shows the effectiveness of the psychosocial networks group in improving the overall HRQOL of the PLWHAs.

  18. Copy number variations of chromosome 16p13.1 region associated with schizophrenia

    DEFF Research Database (Denmark)

    Ingason, A; Rujescu, D; Cichon, S

    2011-01-01

    .007) and deletions in 0.12 % of cases and 0.04% of controls (P>0.05). The region can be divided into three intervals defined by flanking low copy repeats. Duplications spanning intervals I and II showed the most significant (P = 0.00010) association with schizophrenia. The age of onset in duplication and deletion...... carriers among cases ranged from 12 to 35 years, and the majority were males with a family history of psychiatric disorders. In a single Icelandic family, a duplication spanning intervals I and II was present in two cases of schizophrenia, and individual cases of alcoholism, attention deficit hyperactivity...

  19. [Regional features of food standards and health risks associated with chemical contamination of food].

    Science.gov (United States)

    Klepikov, O V; Khatuaev, R O; Istomin, A V; Rumyantseva, L A

    In the article there are presented results of a study of the balance of food consumption by the population of the Voronezh region, the assessment of the level of contamination of food products and both carcinogenic and non-carcinogenic and public health risk caused by this contamination. There was evaluated the level of nutrition-dependent diseases. A special feature of this study is a comparative analysis of data obtained during the two five-year periods of 1995-1999 and 2010-2014, that permitted to reveal changes in food consumption, the dynamics of morbidity rate associated with the nutritional factor.

  20. Scintillations associated with bottomside sinusoidal irregularities in the equatorial F region

    Science.gov (United States)

    Basu, S.; Basu, S.; Valladares, C. E.; Dasgupta, A.; Whitney, H. E.

    1986-01-01

    Multisatellite scintillation observations and spaced receiver drift measurements are presented for a category of equatorial F region plasma irregularities characterized by nearly sinusoidal waveforms in the ion number density. The observations were made at Huancayo, Peru, and the measurements at Ancon, Peru, associated with irregularities observed by the Atmospheric-Explorer-E satellite on a few nights in December 1979. Utilizing ray paths to various geostationary satellites, it was found that the irregularities grow and decay almost simultaneously in long-lived patches extending at least 1000 km in the east-west direction.

  1. Association between VNTR polymorphism in promoter region of prodynorphin (PDYN) gene and heroin dependence.

    Science.gov (United States)

    Saify, Khyber; Saadat, Iraj; Saadat, Mostafa

    2014-11-30

    Within the core promoter region of prodynorphin (PDYN), a 68-bp sequence was found to occur as a polymorphism element, either singular or as tandemly repeated two, three or four times. We report the sequence of a novel allele (5-repeats). Our study revealed the existence of an ancestral nucleotide (A) at 29th position of the VNTR in human. In total, 442 heroin addicts and 799 controls were included in this study. The present findings revealed a male-limited association between VNTR polymorphism and heroin dependence risk. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Targeted resequencing of regulatory regions at schizophrenia risk loci: Role of rare functional variants at chromatin repressive states.

    Science.gov (United States)

    González-Peñas, Javier; Amigo, Jorge; Santomé, Luis; Sobrino, Beatriz; Brenlla, Julio; Agra, Santiago; Paz, Eduardo; Páramo, Mario; Carracedo, Ángel; Arrojo, Manuel; Costas, Javier

    2016-07-01

    There is mounting evidence that regulatory variation plays an important role in genetic risk for schizophrenia. Here, we specifically search for regulatory variants at risk by sequencing promoter regions of twenty-three genes implied in schizophrenia by copy number variant or genome-wide association studies. After strict quality control, a total of 55,206bp per sample were analyzed in 526 schizophrenia cases and 516 controls from Galicia, NW Spain, using the Applied Biosystems SOLiD System. Variants were filtered based on frequency from public databases, chromatin states from the RoadMap Epigenomics Consortium at tissues relevant for schizophrenia, such as fetal brain, mid-frontal lobe, and angular gyrus, and prediction of functionality from RegulomeDB. The proportion of rare variants at polycomb repressive chromatin state at relevant tissues was higher in cases than in controls. The proportion of rare variants with predicted regulatory role was significantly higher in cases than in controls (P=0.0028, OR=1.93, 95% C.I.=1.23-3.04). Combination of information from both sources led to the identification of an excess of carriers of rare variants with predicted regulatory role located at polycomb repressive chromatin state at relevant tissues in cases versus controls (P=0.0016, OR=19.34, 95% C.I.=2.45-2495.26). The variants are located at two genes affected by the 17q12 copy number variant, LHX1 and HNF1B. These data strongly suggest that a specific epigenetic mechanism, chromatin remodeling by histone modification during early development, may be impaired in a subset of schizophrenia patients, in agreement with previous data. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. CHARCOAL PRICE ANALYSIS IN FOUR REGIONS OF MINAS GERAIS STATE-BRAZIL

    Directory of Open Access Journals (Sweden)

    José Luiz Pereira de Rezende

    2005-09-01

    Full Text Available The State of Minas Gerais is the largest producer and consumer of charcoal, that is used as term-reducer of iron ore,for producing pig iron. This study analyzed the time series of charcoal prices in four regions of Minas Gerais State. For the analysisof the price series, the SARIMA model was used, for finding a model that better forecasts prices for the four studied areas. The mostappropriate models were chosen using graphical analyses of the standardized residues, autocorrelation functions and partialautocorrelations, stochastic tests and criteria of evaluation of the order of the model. It concluded that: the differences of charcoalprices occur, basically, due to the geographical location; the analyses of domain of the time and domain of the frequency showed thatthere is difference in the price series of the four studied areas; the areas of Sete Lagoas and Belo Horizonte, giving that they are closelylocated, possess similar prices and they generated similar model; the studied areas presented differentiated models and supplied goodadjustments for the observed series. The best models were SARIMA (2,1,1x(1,0,012, for Belo Horizonte; SARIMA (2,0,0x(2,1,212,for Divinópolis; SARIMA (2,1,1x(1,0,012, for Sete Lagoas and SARIMA (1,1,1x(1,1,112, for Vertentes. Such models presented in aparsimonious way, containing a small number of parameters. All models SARIMA (p,d,q (P,D,Qs, for the four studied areas,presented white noise and supplied adequate price forecast.

  4. Association of the serotonin transporter-linked polymorphic region genotype with lower bone mineral density.

    Science.gov (United States)

    Lapid, M I; Kung, S; Frye, M A; Biernacka, J M; Geske, J R; Drake, M T; Jankowski, M D; Clarke, B L

    2017-08-22

    The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. We aimed to determine whether 5-HTTLPR was associated with bone loss. This cross-sectional study included psychiatric patients with both 5-HTTLPR analysis and bone mineral density (BMD) assessment (hip and spine Z-scores if age <50 years and T-scores if ⩾50 years). BMD association with 5-HTTLPR was evaluated under models with additive allele effects and dominant S allele effects using linear regression models. Patients were stratified by age (<50 and ⩾50 years) and sex. Of 3016 patients with 5-HTTLPR genotyping, 239 had BMD assessments. Among the younger patients, the S allele was associated with lower Z-scores at the hip (P=0.002, dominant S allele effects; P=0.004, additive allele effects) and spine (P=0.0006, dominant S allele effects; P=0.01, additive allele effects). In sex-stratified analyses, the association of the S allele with lower BMD in the younger patients was also significant in the subset of women (P⩽0.003 for both hip and spine BMD under the additive allele effect model). In the small group of men younger than 50 years, the S allele was marginally associated with higher spine BMD (P=0.05). BMD T-scores were not associated with 5-HTTLPR genotypes in patients 50 years or older. The 5-HTTLPR variants may modify serotonin effects on bone with sex-specific effects.

  5. Genome-wide association study identified CNP12587 region underlying height variation in Chinese females.

    Directory of Open Access Journals (Sweden)

    Yin-Ping Zhang

    Full Text Available Human height is a highly heritable trait considered as an important factor for health. There has been limited success in identifying the genetic factors underlying height variation. We aim to identify sequence variants associated with adult height by a genome-wide association study of copy number variants (CNVs in Chinese.Genome-wide CNV association analyses were conducted in 1,625 unrelated Chinese adults and sex specific subgroup for height variation, respectively. Height was measured with a stadiometer. Affymetrix SNP6.0 genotyping platform was used to identify copy number polymorphisms (CNPs. We constructed a genomic map containing 1,009 CNPs in Chinese individuals and performed a genome-wide association study of CNPs with height.We detected 10 significant association signals for height (p<0.05 in the whole population, 9 and 11 association signals for Chinese female and male population, respectively. A copy number polymorphism (CNP12587, chr18:54081842-54086942, p = 2.41 × 10(-4 was found to be significantly associated with height variation in Chinese females even after strict Bonferroni correction (p = 0.048. Confirmatory real time PCR experiments lent further support for CNV validation. Compared to female subjects with two copies of the CNP, carriers of three copies had an average of 8.1% decrease in height. An important candidate gene, ubiquitin-protein ligase NEDD4-like (NEDD4L, was detected at this region, which plays important roles in bone metabolism by binding to bone formation regulators.Our findings suggest the important genetic variants underlying height variation in Chinese.

  6. Factors associated with HIV among female sex workers in a high HIV prevalent state of India.

    Science.gov (United States)

    Medhi, Gajendra Kumar; Mahanta, Jagadish; Paranjape, Ramesh S; Adhikary, Rajatashuvra; Laskar, Nabjyoti; Ngully, P

    2012-01-01

    The study was carried out to assess the factors associated with HIV seropositivity among female sex workers (FSWs) in Dimapur, Nagaland, a high HIV prevalence state of India. A total of 426 FSWs were recruited into the study using respondent driven sampling (RDS). Data on demographic characteristics, sexual and injecting risk behaviours were collected from them and were tested for HIV, Syphilis, Neisseria gonorrhoeae and Chlamydia trachomatis. RDS-weighted univariate and multivariate logistic regression analysis was performed to assess the factors associated with HIV seropositivity. Consistent condom use with regular and occasional sexual clients was 9% and 16.4%, respectively. About 25% of the participants ever used and 5.7% ever injected illicit drugs. RDS adjusted HIV prevalence was 11.6%. In the univariate analysis, factors associated with HIV were initiating sexual intercourse before the age of 15 years, ≥2 years duration of sex work, serving clients at lodge/hotel, positive test result for one or more sexually transmitted infections (STIs), lifetime history of injecting drug use, lifetime history of consuming illicit drugs, ever having exchanged sex for drugs, having sexual partners who engaged in risky injecting practices and having been widowed or divorced. In multivariate analysis, factors found to be independently associated with HIV included lifetime injecting drug use, initiating sexual intercourse before the age of 15 years, positive test result for one or more STIs and having been widowed. Injecting drug use was found to be most potent independent risk factor for HIV (OR: 3.17, CI: 1.02-9.89). Because of lower consistent condom use among them, FSWs may act as bridge for HIV transmission to general population from injecting drug users (IDU) through their sexual clients. The informations from this study may be useful for enriching the HIV preventions effort for FSWs in this region.

  7. Observation of associated production of a $Z$ boson with a $D$ meson in the forward region

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Callot, Olivier; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coca, Cornelia; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bonis, Isabelle; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dorosz, Piotr; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; van Eijk, Daan; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Fitzpatrick, Conor; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garosi, Paola; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Hafkenscheid, Tom; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Huse, Torkjell; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Iakovenko, Viktor; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Wallaa; Karacson, Matthias; Karbach, Moritz; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Klaver, Suzanne; Kochebina, Olga; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Guoming; Lohn, Stefan; Longstaff, Ian; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luisier, Johan; Luo, Haofei; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Manca, Giulia; Mancinelli, Giampiero; Manzali, Matteo; Maratas, Jan; Marconi, Umberto; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Mountain, Raymond; Mous, Ivan; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Muryn, Bogdan; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neubert, Sebastian; Neufeld, Niko; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pavel-Nicorescu, Carmen; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Polok, Grzegorz; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Powell, Andrew; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redford, Sophie; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Alexander; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Roberts, Douglas; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruffini, Fabrizio; Ruiz, Hugo; Ruiz Valls, Pablo; Sabatino, Giovanni; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sapunov, Matvey; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Senderowska, Katarzyna; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Oksana; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Stagni, Federico; Stahl, Sascha; Steinkamp, Olaf; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teodorescu, Eliza; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Webber, Adam Dane; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiechczynski, Jaroslaw; Wiedner, Dirk; Wiggers, Leo; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    A search for associated production of a $Z$ boson with an open charm meson is presented using a data sample, corresponding to an integrated luminosity of $1.0\\mathrm{fb}^{-1}$ of proton--proton collisions at a centre-of-mass energy of 7 TeV, collected by the LHCb experiment. Seven candidate events for associated production of a $Z$ boson with a $D^0$ meson and four candidate events for a $Z$ boson with a $D^+$ meson are observed with a combined significance of 5.1 standard deviations. The production cross-sections in the forward region are measured to be $$\\sigma_{Z\\rightarrow\\mu^+\\mu^-\\!,D^0} = 2.50\\pm1.12\\pm0.22pb$$ $$\\sigma_{Z\\rightarrow\\mu^+\\mu^-\\!,D^+} = 0.44\\pm0.23\\pm0.03pb,$$ where the first uncertainty is statistical and the second systematic.

  8. Complex regional pain syndrome with associated chest wall dystonia: a case report

    Directory of Open Access Journals (Sweden)

    Schwartzman Robert J

    2011-09-01

    Full Text Available Abstract Patients with complex regional pain syndrome (CRPS often suffer from an array of associated movement disorders, including dystonia of an affected limb. We present a case of a patient with long standing CRPS after a brachial plexus injury, who after displaying several features of the movement disorder previously, developed painful dystonia of chest wall musculature. Detailed neurologic examination found palpable sustained contractions of the pectoral and intercostal muscles in addition to surface allodynia. Needle electromyography of the intercostal and paraspinal muscles supported the diagnosis of dystonia. In addition, pulmonary function testing showed both restrictive and obstructive features in the absence of a clear cardiopulmonary etiology. Treatment was initiated with intrathecal baclofen and the patient had symptomatic relief and improvement of dystonia. This case illustrates a novel form of the movement disorder associated with CRPS with response to intrathecal baclofen treatment.

  9. Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins.

    Science.gov (United States)

    Pradhan, Mohan R; Pal, Arumay; Hu, Zhongqiao; Kannan, Srinivasaraghavan; Chee Keong, Kwoh; Lane, David P; Verma, Chandra S

    2016-02-01

    Aggregation is an irreversible form of protein complexation and often toxic to cells. The process entails partial or major unfolding that is largely driven by hydration. We model the role of hydration in aggregation using "Dehydrons." "Dehydrons" are unsatisfied backbone hydrogen bonds in proteins that seek shielding from water molecules by associating with ligands or proteins. We find that the residues at aggregation interfaces have hydrated backbones, and in contrast to other forms of protein-protein interactions, are under less evolutionary pressure to be conserved. Combining evolutionary conservation of residues and extent of backbone hydration allows us to distinguish regions on proteins associated with aggregation (non-conserved dehydron-residues) from other interaction interfaces (conserved dehydron-residues). This novel feature can complement the existing strategies used to investigate protein aggregation/complexation. © 2015 Wiley Periodicals, Inc.

  10. Gender differences in association between serotonin transporter gene polymorphism and resting-state EEG activity.

    Science.gov (United States)

    Volf, N V; Belousova, L V; Knyazev, G G; Kulikov, A V

    2015-01-22

    Human brain oscillations represent important features of information processing and are highly heritable. Gender has been observed to affect association between the 5-HTTLPR (serotonin-transporter-linked polymorphic region) polymorphism and various endophenotypes. This study aimed to investigate the effects of 5-HTTLPR on the spontaneous electroencephalography (EEG) activity in healthy male and female subjects. DNA samples extracted from buccal swabs and resting EEG recorded at 60 standard leads were collected from 210 (101 men and 109 women) volunteers. Spectral EEG power estimates and cortical sources of EEG activity were investigated. It was shown that effects of 5-HTTLPR polymorphism on electrical activity of the brain vary as a function of gender. Women with the S/L genotype had greater global EEG power compared to men with the same genotype. In men, current source density was markedly different among genotype groups in only alpha 2 and alpha 3 frequency ranges: S/S allele carriers had higher current source density estimates in the left inferior parietal lobule in comparison with the L/L group. In women, genotype difference in global power asymmetry was found in the central-temporal region. Contrasting L/L and S/L genotype carriers also yielded significant effects in the right hemisphere inferior parietal lobule and the right postcentral gyrus with L/L genotype carriers showing lower current source density estimates than S/L genotype carriers in all but gamma bands. So, in women, the effects of 5-HTTLPR polymorphism were associated with modulation of the EEG activity in a wide range of EEG frequencies. The significance of the results lies in the demonstration of gene by sex interaction with resting EEG that has implications for understanding sex-related differences in affective states, emotion and cognition. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

  11. Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke

    International Nuclear Information System (INIS)

    Yassi, Nawaf; Campbell, Bruce C.V.; Davis, Stephen M.; Bivard, Andrew; Moffat, Bradford A.; Steward, Christopher; Desmond, Patricia M.; Churilov, Leonid; Donnan, Geoffrey A.; Parsons, Mark W.

    2016-01-01

    Cerebral atrophy after stroke is associated with poor functional outcome. The prediction and prevention of post-stroke brain atrophy could therefore represent a target for neurorestorative therapies. We investigated the associations between peri-infarct metabolite concentrations measured by quantitative MRS and brain volume change in the infarct hemisphere after stroke. Twenty patients with ischemic stroke were enrolled. Patients underwent 3T-MRI within 1 week of onset, and at 1 and 3 months. At the baseline scan, an MRS voxel was placed manually in the peri-infarct area and another in the corresponding contralateral region. Volumetric analysis of T1 images was performed using two automated processing packages. Changes in gray and white matter volume were assessed as percentage change between 1 and 3 months. Mean concentrations (institutional units) of N-acetylaspartic acid (NAA) (6.1 vs 7.0, p = 0.039), total creatine (Cr+PCr) (5.4 vs 5.8, p = 0.043), and inositol (4.5 vs 5.0, p = 0.014), were significantly lower in the peri-infarct region compared with the contralateral hemisphere. There was a significant correlation between baseline peri-infarct NAA and white matter volume change in the infarct hemisphere between 1 and 3 months, with lower NAA being associated with subsequent white matter atrophy (Spearman's rho = 0.66, p = 0.010). The baseline concentration of Cr+PCr was also significantly correlated with white matter atrophy in the infarct hemisphere (Spearman's rho = 0.59, p = 0.027). Both of these associations were significant after adjustment for the false discovery rate and were validated using the secondary volumetric method. MRS may be useful in the prediction of white matter atrophy post-stroke and in the testing of novel neurorestorative therapies. (orig.)

  12. Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke

    Energy Technology Data Exchange (ETDEWEB)

    Yassi, Nawaf; Campbell, Bruce C.V.; Davis, Stephen M.; Bivard, Andrew [Melbourne Brain Centre rate at The Royal Melbourne Hospital, Departments of Medicine and Neurology, Parkville, Victoria (Australia); Moffat, Bradford A.; Steward, Christopher; Desmond, Patricia M. [The University of Melbourne, Department of Radiology, The Royal Melbourne Hospital, Parkville (Australia); Churilov, Leonid; Donnan, Geoffrey A. [The University of Melbourne, Florey Institute of Neuroscience and Mental Health, Parkville (Australia); Parsons, Mark W. [University of Newcastle and Hunter Medical Research Institute, Priority Research Centre for Translational Neuroscience and Mental Health, Newcastle (Australia)

    2016-01-15

    Cerebral atrophy after stroke is associated with poor functional outcome. The prediction and prevention of post-stroke brain atrophy could therefore represent a target for neurorestorative therapies. We investigated the associations between peri-infarct metabolite concentrations measured by quantitative MRS and brain volume change in the infarct hemisphere after stroke. Twenty patients with ischemic stroke were enrolled. Patients underwent 3T-MRI within 1 week of onset, and at 1 and 3 months. At the baseline scan, an MRS voxel was placed manually in the peri-infarct area and another in the corresponding contralateral region. Volumetric analysis of T1 images was performed using two automated processing packages. Changes in gray and white matter volume were assessed as percentage change between 1 and 3 months. Mean concentrations (institutional units) of N-acetylaspartic acid (NAA) (6.1 vs 7.0, p = 0.039), total creatine (Cr+PCr) (5.4 vs 5.8, p = 0.043), and inositol (4.5 vs 5.0, p = 0.014), were significantly lower in the peri-infarct region compared with the contralateral hemisphere. There was a significant correlation between baseline peri-infarct NAA and white matter volume change in the infarct hemisphere between 1 and 3 months, with lower NAA being associated with subsequent white matter atrophy (Spearman's rho = 0.66, p = 0.010). The baseline concentration of Cr+PCr was also significantly correlated with white matter atrophy in the infarct hemisphere (Spearman's rho = 0.59, p = 0.027). Both of these associations were significant after adjustment for the false discovery rate and were validated using the secondary volumetric method. MRS may be useful in the prediction of white matter atrophy post-stroke and in the testing of novel neurorestorative therapies. (orig.)

  13. The past and present of female associations in the Region of Campania

    Directory of Open Access Journals (Sweden)

    Gabriella Botti

    2012-10-01

    Full Text Available During the post-war period there was a widespread people's mobilization, in which women devoted themselves to social work. This also involved a great commitment to politics.Female historian associations contributed to women's commitment to social work and the creation of a women's relevant role in the country reconstruction. In particu-lar, Unione Donne Italiane (Udi and Centro Italiano Femminile (Cif were the two mass female associations related to the two most relevant political parties in the post-war period (i.e. Partito Comunista Italiano and Democrazia Cristiana.Besides being involved in institutional matters, women were also engaged in ac-tivities on the spot throughout Italy.The issue is whether female associations have, at present, lost their presence on the spot in such a disruptive time.In the post-war period women were involved in the country reconstruction by pro-viding people with socially supportive activities. These activities received an official acknowledgement by the State through the creation of a welfare state and new profes-sionals such as social workers.Nowadays, however, commitment to social work is not any longer a successful link to the job market for women.

  14. Integrated Assessment of Climate Change, Land-Use Changes, and Regional Carbon Dynamics in United States

    Science.gov (United States)

    Mu, J. E.; Sleeter, B. M.; Abatzoglou, J. T.

    2015-12-01

    (e.g., counties in the United States) and aggregate to states or eco-logical regions. Alternative approach used in previous literature is the top-down approach, which depends on global economic model projections and downscaling methods. Compared to the top-down approach, our approach is more realistic by using observed data.

  15. Using Climate Regionalization to Understand Climate Forecast System Version 2 (CFSv2) Precipitation Performance for the Conterminous United States (CONUS)

    Science.gov (United States)

    Regonda, Satish K.; Zaitchik, Benjamin F.; Badr, Hamada S.; Rodell, Matthew

    2016-01-01

    Dynamically based seasonal forecasts are prone to systematic spatial biases due to imperfections in the underlying global climate model (GCM). This can result in low-forecast skill when the GCM misplaces teleconnections or fails to resolve geographic barriers, even if the prediction of large-scale dynamics is accurate. To characterize and address this issue, this study applies objective climate regionalization to identify discrepancies between the Climate Forecast SystemVersion 2 (CFSv2) and precipitation observations across the Contiguous United States (CONUS). Regionalization shows that CFSv2 1 month forecasts capture the general spatial character of warm season precipitation variability but that forecast regions systematically differ from observation in some transition zones. CFSv2 predictive skill for these misclassified areas is systematically reduced relative to correctly regionalized areas and CONUS as a whole. In these incorrectly regionalized areas, higher skill can be obtained by using a regional-scale forecast in place of the local grid cell prediction.

  16. Recent Regional Climate State and Change - Derived through Downscaling Homogeneous Large-scale Components of Re-analyses

    Science.gov (United States)

    Von Storch, H.; Klehmet, K.; Geyer, B.; Li, D.; Schubert-Frisius, M.; Tim, N.; Zorita, E.

    2015-12-01

    Global re-analyses suffer from inhomogeneities, as they process data from networks under development. However, the large-scale component of such re-analyses is mostly homogeneous; additional observational data add in most cases to a better description of regional details and less so on large-scale states. Therefore, the concept of downscaling may be applied to homogeneously complementing the large-scale state of the re-analyses with regional detail - wherever the condition of homogeneity of the large-scales is fulfilled. Technically this can be done by using a regional climate model, or a global climate model, which is constrained on the large scale by spectral nudging. This approach has been developed and tested for the region of Europe, and a skillful representation of regional risks - in particular marine risks - was identified. While the data density in Europe is considerably better than in most other regions of the world, even here insufficient spatial and temporal coverage is limiting risk assessments. Therefore, downscaled data-sets are frequently used by off-shore industries. We have run this system also in regions with reduced or absent data coverage, such as the Lena catchment in Siberia, in the Yellow Sea/Bo Hai region in East Asia, in Namibia and the adjacent Atlantic Ocean. Also a global (large scale constrained) simulation has been. It turns out that spatially detailed reconstruction of the state and change of climate in the three to six decades is doable for any region of the world.The different data sets are archived and may freely by used for scientific purposes. Of course, before application, a careful analysis of the quality for the intended application is needed, as sometimes unexpected changes in the quality of the description of large-scale driving states prevail.

  17. Nitrogen use efficiency and crop production: Patterns of regional variation in the United States, 1987-2012.

    Science.gov (United States)

    Swaney, Dennis P; Howarth, Robert W; Hong, Bongghi

    2018-04-17

    National-level summaries of crop production and nutrient use efficiency, important for international comparisons, only partially elucidate agricultural dynamics within a country. Agricultural production and associated environmental impacts in large countries vary significantly because of regional differences in crops, climate, resource use and production practices. Here, we review patterns of regional crop production, nitrogen use efficiency (NUE), and major inputs of nitrogen to US crops over 1987-2012, based on the Farm Resource Regions developed by the Economic Research Service (USDA-ERS). Across the US, NUE generally decreased over time over the period studied, mainly due to increased use in mineral N fertilizer above crop N requirements. The Heartland region dominates production of major crops and thus tends to drive national patterns, showing linear response of crop production to nitrogen inputs broadly consistent with an earlier analysis of global patterns of country-scale data by Lassaletta et al. (2014). Most other regions show similar responses, but the Eastern Uplands region shows a negative response to nitrogen inputs, and the Southern Seaboard shows no significant relationship. The regional differences appear as two branches in the response of aggregate production to N inputs on a cropland area basis, but not on a total area basis, suggesting that the type of scaling used is critical under changing cropland area. Nitrogen use efficiency (NUE) is positively associated with fertilizer as a percentage of N inputs in four regions, and all regions considered together. NUE is positively associated with crop N fixation in all regions except Northern Great Plains. It is negatively associated with manure (livestock excretion); in the US, manure is still treated largely as a waste to be managed rather than a nutrient resource. This significant regional variation in patterns of crop production and NUE vs N inputs, has implications for environmental quality and

  18. Mineralogical and geochemical aspects of nickeliferous laterite of Vermelho region, Serra dos Carajas (State of Para)

    International Nuclear Information System (INIS)

    Almeida Correa, S.L. de.

    1982-01-01

    Mineralogical and geochemical studies were carried out on the nickeliferous laterite of Vermelho region (Serra of Carajas, state of Para). A total of 64 samples were analysed by X-ray fluorescence analysis and atomic absorption, spectrophotometry, including bed-rock specimens. The laterite is derived from ultramafic rocks (serpentinites) and there horizons were recognized towards the top: saprolitic horizon with a thickness of more than 4 meters, clay horizon 6,1 meters thick and limonitic horizon with a thickness of 8,3 meters. The process of weathering affected both major and trace elements which were bleached, transported and reprecipitated. This caused variations in the concentration of the elements with depth, except for magnesium which was extensively bleached. Nickel concentrations in the clay horizon probably was a result of ion exchange between smectite and Ni-bearing solutions, the source of this Ni being goethite. Cobalt and zinc were also strongly enriched during the process of laterization, although maximum concentrations of these elements are found in different horizons. (author)

  19. Space geodiversity review: a case study in the southwestern region of Paraná State, Brazil.

    Science.gov (United States)

    Manosso, Fernando; Tauana Basso, Bruna; Alcindo Da Roza, Douglas; Souza dos Santos, Daniel

    2015-04-01

    Considering the strong global concern for nature protection, improvements emerge to support techniques to understand physical and biological means of selecting areas for environmental conservation. Most techniques take into consideration mainly the biological characteristics of nature, however as the nature is a complex of biotic and abiotic elements it becomes thus necessary the creation of parameters to understand the diversity of abiotic elements, their distribution, occurrence, threats and values as well. This paper aims to identify, quantify and perform a spatial analysis of the distribution of geodiversity in the southwestern region of Paraná State, Brazil, from the different concepts of geodiversity with the use of techniques on digital cartographic database in a Geographic Information System - GIS. Gray (2004) conceptualized geodiversity as the natural distribution of geology, including rocks, minerals, fossils, soil characteristics, land forms and processes (geomorphology), and their connections. Geodiversity is composed by the variability of abiotic nature, including lithological elements, tectonic, geomorphological, edaphic, hydrological, topographical and physical processes of the Earth surface, seas, oceans, together with natural endogenous, exogenous and anthropogenic processes that include a diversity of particles, elements and places (Serrano and Ruiz Flaño, 2007). Different methods of quantitative assessment of geodiversity in different territories were applied by Carcavilla et al (2007), Pellitero and González-Amuchastegui (2010), Navarro (2010), Katerina and Dušan (2008), Serrano et al (2007; 2009), Kozlowski (2010), Zwolinski and Stachowiak (2012), Thomas (2012), Hjort and Luoto (2010; 2012), Pellitero et al (2014), and Silva (2014). Considering geodiversity as the abiotic elements which constitute the landscape; it is important to mention that such set may vary spatially according to the occurrence of different geological formations, rock

  20. Job satisfaction and associated factors among health professionals working at Western Amhara Region, Ethiopia.

    Science.gov (United States)

    Temesgen, Kalkidan; Aycheh, Moges Wubie; Leshargie, Cheru Tesema

    2018-04-17

    In Ethiopia assuring the satisfaction of health care provider with their job is a major challenging problem. Job satisfaction is a worker's emotional response to different job related factors resulting in finding pleasure, comfort, confidence, rewards, personal growth and various positive opportunities, including upward mobility, recognition, and appraisal done on a merit pattern with monetary value as compensation. Professionals, whose needs and expectations are satisfied, tend to be more productive compared to their colleagues. Thus, study is aimed at assessing job satisfaction and associated factors among health professionals working at Western Amhara region, Ethiopia. An institution-based cross sectional study was conducted on March 2016 at Western Amhara region among 575 health professionals selected using simple random sampling. Logistic regression analysis was used to identify factors related to job satisfaction. Variables which have p-value less than or equal to 0.05 with corresponding AOR at 95 confidence interval was considered to declare the significance association. This study revealed that job satisfaction of health professional working at Western Amhara region was 31.7%. The mean age of respondent was 27.13 years. Majority of them, 79.3% and 95.3% were less than 30 years in age and orthodox Christian religion followers respectively. The presence of health professionals' reference manual/guide, alcohol drinking, workload, experience, educational status and profession types were identified as significant factors associated with health care professionals' job satisfaction level. Professional being laboratory technicians, pharmacists and Environmental health workers were 4.86 times more likely to satisfy themselves than nurses, midwives and Public health officers. Similarly, in their educational status, degree and above holders were 5.64 times more likely to satisfy themselves than below degree holders. Health professionals whose experience with > 3

  1. Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males.

    Science.gov (United States)

    Liao, Ding-Lieh; Hong, Chen-Jee; Shih, Hao-Ling; Tsai, Shih-Jen

    2004-01-01

    The neurotransmitter, serotonin, has been implicated in aggressive behavior. The serotonin transporter (5-HTT), which reuptakes serotonin into the nerve terminal, plays a critical role in the regulation of serotonergic function. Previous western reports have demonstrated that the low-activity short (S) allele of the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with aggressive behavior and associated personality traits. In the present study, we investigated this 5-HTTLPR genetic polymorphism in a group of Chinese males who had been convicted for extremely violent crime (n = 135) and a normal control group (n = 111). The proportion of S-allele carriers was significantly higher in the criminal group than in the controls (p = 0.006). A significant association was not demonstrated for the relationship between the 5-HTTLPR polymorphism and antisocial personality disorder, substance abuse or alcohol abuse in the criminal group. Our findings demonstrate that carriage of the low-activity S allele is associated with extremely violent criminal behavior in Chinese males, and suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors.

  2. Immunochip analysis identifies association of the RAD50/IL13 region with human longevity

    DEFF Research Database (Denmark)

    Flachsbart, Friederike; Ellinghaus, David; Gentschew, Liljana

    2016-01-01

    Human longevity is characterized by a remarkable lack of confirmed genetic associations. Here, we report on the identification of a novel locus for longevity in the RAD50/IL13 region on chromosome 5q31.1 using a combined European sample of 3208 long-lived individuals (LLI) and 8919 younger controls....... First, we performed a large-scale association study on 1458 German LLI (mean age 99.0 years) and 6368 controls (mean age 57.2 years) by targeting known immune-associated loci covered by the Immunochip. The analysis of 142 136 autosomal single nucleotide polymorphisms (SNPs) revealed an Immunochip...... (1257 LLI, mean age 102.4 years; 1811 controls, mean age 49.1 years) and Denmark (493 LLI, mean age 96.2 years; 740 controls, mean age 63.1 years). The association at SNP rs2706372 replicated in the French study collection and showed a similar trend in the Danish participants and was also significant...

  3. Innovative Approaches to Collaborative Groundwater Governance in the United States: Case Studies from Three High-Growth Regions in the Sun Belt

    Science.gov (United States)

    Megdal, Sharon B.; Gerlak, Andrea K.; Huang, Ling-Yee; Delano, Nathaniel; Varady, Robert G.; Petersen-Perlman, Jacob D.

    2017-05-01

    Groundwater is an increasingly important source of freshwater, especially where surface water resources are fully or over-allocated or becoming less reliable due to climate change. Groundwater reliance has created new challenges for sustainable management. This article examines how regional groundwater users coordinate and collaborate to manage shared groundwater resources, including attention to what drives collaboration. To identify and illustrate these facets, this article examines three geographically diverse cases of groundwater governance and management from the United States Sun Belt: Orange County Water District in southern California; Prescott Active Management Area in north-central Arizona; and the Central Florida Water Initiative in central Florida. These regions have different surface water laws, groundwater allocation and management laws and regulations, demographics, economics, topographies, and climate. These cases were selected because the Sun Belt faces similar pressures on groundwater due to historical and projected population growth and limited availability of usable surface water supplies. Collectively, they demonstrate groundwater governance trends in the United States, and illustrate distinctive features of regional groundwater management strategies. Our research shows how geophysical realities and state-level legislation have enabled and/or stimulated regions to develop groundwater management plans and strategies to address the specific issues associated with their groundwater resources. We find that litigation involvement and avoidance, along with the need to finance projects, are additional drivers of regional collaboration to manage groundwater. This case study underscores the importance of regionally coordinated and sustained efforts to address serious groundwater utilization challenges faced by the regions studied and around the world.

  4. Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization.

    Science.gov (United States)

    Ueshima, Shuhei; Nagata, Kyosuke; Okuwaki, Mitsuru

    2017-11-15

    Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA genes and mediates the formation of transcriptionally active chromatin in the nucleolus. However, it remains unknown how UBF is specifically localized to the nucleolus. Here, we examined the molecular mechanisms that localize UBF to the nucleolus. We found that the first HMG box (HMG box 1), the linker region (LR), and the AR cooperatively regulate the nucleolar localization of UBF1. We demonstrated that the AR intramolecularly associates with and attenuates the DNA binding activity of HMG boxes and confers the structured DNA preference to HMG box 1. In contrast, the LR was found to serve as a nuclear localization signal and compete with HMG boxes to bind the AR, permitting nucleolar localization of UBF1. The LR sequence binds DNA and assists the stable chromatin binding of UBF. We also showed that the phosphorylation status of the AR does not clearly affect the localization of UBF1. Our results strongly suggest that associations of the AR with HMG boxes and the LR regulate UBF nucleolar localization. Copyright © 2017 American Society for Microbiology.

  5. White grubs (Coleoptera, Melolonthidae in the "Planalto Region", Rio Grande do Sul state, Brazil: Key for identification, species richness and distribution

    Directory of Open Access Journals (Sweden)

    Mariana A. Cherman

    2013-09-01

    Full Text Available White grubs (Coleoptera, Melolonthidae in the "Planalto Region", Rio Grande do Sul state, Brazil: Key for identification, species richness and distribution. The objective of this study was to survey the occurrence and geographic distribution of white grub species (Coleoptera, Melolonthidae in cultivated and non-cultivated fields of the "Planalto Region", Rio Grande do Sul state, Brazil and develop a key at genus-level. Twenty-eight species from 15 genera and three subfamilies were recorded: Dynastinae, Melolonthinae and Rutelinae. The species or genera recorded for the first time in the state are: Cyclocephala metrica, C. tucumana, Isonychus albicinctus, Liogenys bidenticeps, L. fusca, L. obesa and L. sinuaticeps, Paranomala violacea, as well as unidentified species of Amononyx, Dicrania, Leucothyreus, Macrodactylus, Plectris and Rhizogeniates. Among the species recorded, 23 were associated with winter crops. Only Cyclocephala metrica, Dyscinetus rugifrons, two species of Leucothyreus and one species of the tribe Sericini were not present in cultivated crop fields. Cyclocephala flavipennis and Diloboderus abderus occurred in most of the municipalities sampled, often associated with Plectris sp., C. modesta and C. putrida. The highest richness of melolonthids was concentrated in the northeast of the Planalto region.

  6. Regional disparity of urban passenger transport associated GHG (greenhouse gas) emissions in China: A review

    International Nuclear Information System (INIS)

    Hao, Han; Geng, Yong; Wang, Hewu; Ouyang, Minggao

    2014-01-01

    With China’s urbanization and motorization, greenhouse gas (GHG) emissions from urban passenger transport increased rapidly over recent years. As we estimated, China’s urban passenger transport associated motorized travel, energy consumption and lifecycle GHG emissions reached 2815 billion passenger kilometers (pkm), 77 million tons of oil equivalent (toe) and 335 million ton CO 2 equivalent in 2010, over half of which were located in eastern provinces. Over national level, GHG emissions by private passenger vehicles, business passenger vehicles, taxis, motorcycles, E-bikes, transit buses and urban rails accounted for 57.7%, 13.0%, 7.7%, 8.6%, 1.8%, 10.5% and 0.7% of the total. Significant regional disparity was observed. The province-level per capita GHG emissions ranged from 285 kg/capita in Guizhou to 1273 kg/capita in Beijing, with national average of 486 kg/capita. Depending on province context and local policy orientation, the motorization pathways of China’s several highest motorized provinces are quite diverse. We concluded that motorization rate and transport structure were the substantial factors determining urban passenger transport associated GHG emissions. Considering the great potential of urban passenger transport growth in China, policies guiding the optimization of transport structure should be in place with priority in eastern provinces. - Highlights: • Province-leveled motorized travel, energy consumption and GHG emissions in China were studied. • Significant regional disparities on urban passenger transport were observed. • Region-specific sustainable transport energy policies were discussed

  7. Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Zheng; Luo, Qi-Zhi; Lin, Lin [Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, Hunan Province (China); Su, Yu-Ping; Peng, Hai-Bo [Central Blood Bank in Yueyang, Yueyang, Hunan Province (China); Du, Kun; Yu, Ping [Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, Hunan Province (China); Wang, Shi-Ping [Key Laboratory of Schistosomiasis in Hunan, Department of Parasitology, College of Basic Medical Sciences, Central South University, Changsha, Hunan Province (China)

    2012-03-02

    Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with susceptibility to some infectious diseases. We determined whether MICA polymorphisms were associated with the high rate of Schistosoma parasitic worm infection or severity of disease outcome in the Dongting Lake region of Hunan Province, China. Polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (SBT) were applied for high-resolution allele typing of schistosomiasis cases (N = 103, age range = 36.2-80.5 years, 64 males and 39 females) and healthy controls (N = 141, age range = 28.6-73.3 years, 73 males and 68 females). Fourteen MICA alleles and five short-tandem repeat (STR) alleles were identified among the two populations. Three (MICA*012:01/02, MICA*017 and MICA*027) showed a higher frequency in healthy controls than in schistosomiasis patients, but the difference was not significantly correlated with susceptibility to S. japonicum infection (Pc > 0.05). In contrast, higher MICA*A5 allele frequency was significantly correlated with advanced liver fibrosis (Pc < 0.05). Furthermore, the distribution profile of MICA alleles in this Hunan Han population was significantly different from those published for Korean, Thai, American-Caucasian, and Afro-American populations (P < 0.01), but similar to other Han populations within China (P > 0.05). This study provides the initial evidence that MICA genetic polymorphisms may underlie the severity of liver fibrosis occurring in schistosomiasis patients from the Dongting Lake region.

  8. Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region

    International Nuclear Information System (INIS)

    Gong, Zheng; Luo, Qi-Zhi; Lin, Lin; Su, Yu-Ping; Peng, Hai-Bo; Du, Kun; Yu, Ping; Wang, Shi-Ping

    2012-01-01

    Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with susceptibility to some infectious diseases. We determined whether MICA polymorphisms were associated with the high rate of Schistosoma parasitic worm infection or severity of disease outcome in the Dongting Lake region of Hunan Province, China. Polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (SBT) were applied for high-resolution allele typing of schistosomiasis cases (N = 103, age range = 36.2-80.5 years, 64 males and 39 females) and healthy controls (N = 141, age range = 28.6-73.3 years, 73 males and 68 females). Fourteen MICA alleles and five short-tandem repeat (STR) alleles were identified among the two populations. Three (MICA*012:01/02, MICA*017 and MICA*027) showed a higher frequency in healthy controls than in schistosomiasis patients, but the difference was not significantly correlated with susceptibility to S. japonicum infection (Pc > 0.05). In contrast, higher MICA*A5 allele frequency was significantly correlated with advanced liver fibrosis (Pc < 0.05). Furthermore, the distribution profile of MICA alleles in this Hunan Han population was significantly different from those published for Korean, Thai, American-Caucasian, and Afro-American populations (P < 0.01), but similar to other Han populations within China (P > 0.05). This study provides the initial evidence that MICA genetic polymorphisms may underlie the severity of liver fibrosis occurring in schistosomiasis patients from the Dongting Lake region

  9. DO COROTATING INTERACTION REGION ASSOCIATED SHOCKS SURVIVE WHEN THEY PROPAGATE INTO THE HELIOSHEATH?

    International Nuclear Information System (INIS)

    Provornikova, E.; Opher, M.; Izmodenov, V.; Toth, G.

    2012-01-01

    During the solar minimum at the distance of 42-52 AU from the Sun, Voyager 2 observed recurrent sharp, shock-like increases in the solar wind speed that look very much like forward shocks (Lazarus et al.). The shocks were produced by corotating interaction regions (CIRs) that originated near the Sun. After the termination shock (TS) crossing in 2007, Voyager 2 entered the heliosheath and has been observing the plasma emanated during the recent solar minima. Measurements show high variable flow, but there were no shocks detected in the heliosheath. When CIR-driven shocks propagate to the outer heliosphere, their structure changes due to collision and merging processes of CIRs. In this Letter, we explore an effect of the merging of CIRs on the structure of CIR-associated shocks. We use a three-dimensional MHD model to study the outward propagation of the shocks with characteristics similar to those observed by Voyager 2 at ∼45 AU (Lazarus et al. 1999). We show that due to merging of CIRs (1) reverse shocks disappear, (2) forward shocks become weaker due to interaction with rarefaction regions from preceding CIRs, and (3) forward shocks significantly weaken in the heliosheath. Merged CIRs produce compression regions in the heliosheath with small fluctuations of plasma parameters. Amplitudes of the fluctuations diminish as they propagate deeper in the sheath. We conclude that interaction of shocks and rarefaction regions could be one of the explanations, why shocks produced by CIRs are not observed in the heliosheath by Voyager 2 while they were frequently observed upstream the TS.

  10. Radiotherapy is associated with significant improvement in local and regional control in Merkel cell carcinoma

    International Nuclear Information System (INIS)

    Kang, Susan H; Haydu, Lauren E; Goh, Robin Yeong Hong; Fogarty, Gerald B

    2012-01-01

    Merkel cell carcinoma (MCC) is a rare tumour of skin. This study is a retrospective audit of patients with MCC from St Vincent’s and Mater Hospital, Sydney, Australia. The aim of this study was to investigate the influence of radiotherapy (RT) on the local and regional control of MCC lesions and survival of patients with MCC. The data bases in anatomical pathology, RT and surgery. We searched for patients having a diagnosis of MCC between 1996 and 2007. Patient, tumour and treatment characteristics were collected and analysed. Univariate survival analysis of categorical variables was conducted with the Kaplan-Meier method together with the Log-Rank test for statistical significance. Continuous variables were assessed using the Cox regression method. Multivariate analysis was performed for significant univariate results. Sixty seven patients were found. Sixty two who were stage I-III and were treated with radical intent were analysed. 68% were male. The median age was 74 years. Forty-two cases (68%) were stage I or II, and 20 cases (32%) were stage III. For the subset of 42 stage I and II patients, those that had RT to their primary site had a 2-year local recurrence free survival of 89% compared with 36% for patients not receiving RT (p<0.001). The cumulative 2-year regional recurrence free survival for patients having adjuvant regional RT was 84% compared with 43% for patients not receiving this treatment (p<0.001). Immune status at initial surgery was a significant predictor for OS and MCCSS. In a multivariate analysis combining macroscopic size (mm) and immune status at initial surgery, only immune status remained a significant predictor of overall survival (HR=2.096, 95% CI: 1.002-4.385, p=0.049). RT is associated with significant improvement in local and regional control in Merkel cell carcinoma. Immunosuppression is an important factor in overall survival

  11. Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin.

    Science.gov (United States)

    Chang, Kai-Wei; Huang, Nancy A; Liu, I-Hsuan; Wang, Yi-Hui; Wu, Ping; Tseng, Yen-Tzu; Hughes, Michael W; Jiang, Ting Xin; Tsai, Mong-Hsun; Chen, Chien-Yu; Oyang, Yen-Jen; Lin, En-Chung; Chuong, Cheng-Ming; Lin, Shau-Ping

    2015-01-23

    Regional specificity allows different skin regions to exhibit different characteristics, enabling complementary functions to make effective use of the integumentary surface. Chickens exhibit a high degree of regional specificity in the skin and can serve as a good model for when and how these regional differences begin to emerge. We used developing feather and scale regions in embryonic chickens as a model to gauge the differences in their molecular pathways. We employed cosine similarity analysis to identify the differentially regulated and co-regulated genes. We applied low cell techniques for expression validation and chromatin immunoprecipitation (ChIP)-based enhancer identification to overcome limited cell availabilities from embryonic chicken skin. We identified a specific set of genes demonstrating a high correlation as being differentially expressed during feather and scale development and maturation. Some members of the WNT, TGF-beta/BMP, and Notch family known to be involved in feathering skin differentiation were found to be differentially regulated. Interestingly, we also found genes along calcium channel pathways that are differentially regulated. From the analysis of differentially regulated pathways, we used calcium signaling pathways as an example for further verification. Some voltage-gated calcium channel subunits, particularly CACNA1D, are expressed spatio-temporally in the skin epithelium. These calcium signaling pathway members may be involved in developmental decisions, morphogenesis, or epithelial maturation. We further characterized enhancers associated with histone modifications, including H3K4me1, H3K27ac, and H3K27me3, near calcium channel-related genes and identified signature intensive hotspots that may be correlated with certain voltage-gated calcium channel genes. We demonstrated the applicability of cosine similarity analysis for identifying novel regulatory pathways that are differentially regulated during development. Our study

  12. Factors associated with induced abortion at selected hospitals in the Volta Region, Ghana.

    Science.gov (United States)

    Klutsey, Ellen Eyi; Ankomah, Augustine

    2014-01-01

    Induced abortion rates remained persistently high in the Volta Region of Ghana in the 5 years from 2006 to 2011. Some hospitals, both rural and urban, report induced abortion-related complications as one of the top ten conditions in hospital admissions. This study explored demographic and other factors associated with induced abortion, and also assessed awareness of abortion-related complications among women of reproductive age in the Volta Region. A quantitative, hospital-based, unmatched case-control study was performed. The Volta Region was stratified into two health administration zones, ie, north and south. For each zone, hospitals were stratified into government and private hospitals. Employing simple random sampling, one private and three government hospitals were selected from each zone. This study is therefore based on eight hospitals, ie, six government hospitals and two private hospitals. Marital status, employment status, number of total pregnancies, and knowledge about contraception were found to be associated with induced abortion. Multiple logistic regression showed a 4% reduction in the odds of induced abortion in married women compared with women who were single (odds ratio [OR] 0.11, 95% confidence interval [CI] 0.07-0.22). Unemployed women of reproductive age were found to be 0.35 times less likely to seek induced abortion compared with their employed counterparts (OR 0.35, CI 0.19-0.65). It was also observed that women with their second pregnancies were 3.8 times more likely to seek induced abortion and women with more than two pregnancies were 6.6 times more likely to do so (OR 3.81, CI 1.94-7.49 and OR 6.58, CI 2.58-16.79, respectively). Women with no knowledge of contraceptive methods were 4.6 times likely to seek induced abortion (OR 4.64, CI 1.39-15.4). Compared with women who had not had induced abortion, women with a high number of pregnancies and no contraceptive knowledge were more likely to have induced abortion. It was found that lack

  13. Information Communication Technology, State building, and Globalization in the 21st Century: Regional Frameworks for Emerging State Assistance

    National Research Council Canada - National Science Library

    Reese, Justin Y

    2008-01-01

    .... Globalization has modified the essential role of the nation-state towards managing global flows of resource, capital, and populations rather than, as in the past, presiding over distinct national economies...

  14. Simplified two and fifty-one region state-based EEIO model comparison

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supporting data for 2 region and 51 region models assessed in the manuscript "Exploring the relevance of spatial scale to life cycle inventory results using...

  15. Segmental Duplication, Microinversion, and Gene Loss Associated with a Complex Inversion Breakpoint Region in Drosophila

    Science.gov (United States)

    Calvete, Oriol; González, Josefa; Betrán, Esther; Ruiz, Alfredo

    2012-01-01

    Chromosomal inversions are usually portrayed as simple two-breakpoint rearrangements changing gene order but not gene number or structure. However, increasing evidence suggests that inversion breakpoints may often have a complex structure and entail gene duplications with potential functional consequences. Here, we used a combination of different techniques to investigate the breakpoint structure and the functional consequences of a complex rearrangement fixed in Drosophila buzzatii and comprising two tandemly arranged inversions sharing the middle breakpoint: 2m and 2n. By comparing the sequence in the breakpoint regions between D. buzzatii (inverted chromosome) and D. mojavensis (noninverted chromosome), we corroborate the breakpoint reuse at the molecular level and infer that inversion 2m was associated with a duplication of a ∼13 kb segment and likely generated by staggered breaks plus repair by nonhomologous end joining. The duplicated segment contained the gene CG4673, involved in nuclear transport, and its two nested genes CG5071 and CG5079. Interestingly, we found that other than the inversion and the associated duplication, both breakpoints suffered additional rearrangements, that is, the proximal breakpoint experienced a microinversion event associated at both ends with a 121-bp long duplication that contains a promoter. As a consequence of all these different rearrangements, CG5079 has been lost from the genome, CG5071 is now a single copy nonnested gene, and CG4673 has a transcript ∼9 kb shorter and seems to have acquired a more complex gene regulation. Our results illustrate the complex effects of chromosomal rearrangements and highlight the need of complementing genomic approaches with detailed sequence-level and functional analyses of breakpoint regions if we are to fully understand genome structure, function, and evolutionary dynamics. PMID:22328714

  16. A case–control study of epidemiological factors associated with leptospirosis in South Gujarat region

    Directory of Open Access Journals (Sweden)

    K T Desai

    2016-01-01

    Full Text Available Background: The current study was planned to identify the epidemiological factors associated with leptospirosis in South Gujarat region using neighborhood controls. Methods: A total of 100 cases of leptospirosis occurred in South Gujarat region during the year 2012 were selected using simple random sampling. Three neighbors of the selected cases formed the controls (n = 300. A pretested structured questionnaire was used for data collection and data were analyzed using Epi Info 2007. Results: There was significant association of illiteracy (odds ratio [OR] =1.82, 95% confidence interval [CI] =1.14–2.89, working in waterlogged fields during the reference season (OR = 4.6, 95% CI = 1.6–17.9, swimming/bathing in canals, open air defecation practices, storage of cow dung in or surrounding house, residence in the house made up of cow dung walls, households with access of food to rodents, injuries over hands/foot during the endemic season (OR = 3, 95% CI = 1.8–4.8, and history of skin disease during the endemic season (OR = 4.2, 95% CI = 2–8.5, with leptospirosis. Only 10% of individuals had gumboots for protection. A total of 83 (83% cases and 240 (80% controls had taken oral doxycycline chemoprophylaxis (P > 0.05. Cases had taken chemoprophylaxis for a median 4 weeks (range: 1–8 while controls had taken the same for median 8 weeks (range = 1–8 (P < 0.002. Conclusions: Although the commonly established factors appear to be associated with leptospirosis, the role of host factors seems to play a more important role in determining susceptibility to leptospirosis in exposed individuals.

  17. Functional connectivity mapping of regions associated with self- and other-processing.

    Science.gov (United States)

    Murray, Ryan J; Debbané, Martin; Fox, Peter T; Bzdok, Danilo; Eickhoff, Simon B

    2015-04-01

    Neuroscience literature increasingly suggests a conceptual self composed of interacting neural regions, rather than independent local activations, yet such claims have yet to be investigated. We, thus, combined task-dependent meta-analytic connectivity modeling (MACM) with task-independent resting-state (RS) connectivity analysis to delineate the neural network of the self, across both states. Given psychological evidence implicating the self's interdependence on social information, we also delineated the neural network underlying conceptual other-processing. To elucidate the relation between the self-/other-networks and their function, we mined the MACM metadata to generate a cognitive-behavioral profile for an empirically identified region specific to conceptual self, the pregenual anterior cingulate (pACC), and conceptual other, posterior cingulate/precuneus (PCC/PC). Mining of 7,200 published, task-dependent, neuroimaging studies, using healthy human subjects, yielded 193 studies activating the self-related seed and were conjoined with RS connectivity analysis to delineate a differentiated self-network composed of the pACC (seed) and anterior insula, relative to other functional connectivity. Additionally, 106 studies activating the other-related seed were conjoined with RS connectivity analysis to delineate a differentiated other-network of PCC/PC (seed) and angular gyrus/temporoparietal junction, relative to self-functional connectivity. The self-network seed related to emotional conflict resolution and motivational processing, whereas the other-network seed related to socially oriented processing and contextual information integration. Notably, our findings revealed shared RS connectivity between ensuing self-/other-networks within the ventromedial prefrontal cortex and medial orbitofrontal cortex, suggesting self-updating via integration of self-relevant social information. We, therefore, present initial neurobiological evidence corroborating the increasing

  18. Nitrous Oxide Emissions from Biofuel Crops and Atmospheric Aerosols: Associations with Air Quality and Regional Climate

    Science.gov (United States)

    Pillai, Priya Ramachandran

    atmosphere (TOA) shortwave aerosol direct radiative forcing (SWARF) by regionally nucleated particles over a forest site in the Southeastern United States was estimated. Particle size distributions (aerodynamic diameter, Dp 10.2 nm to 250 nm), total number concentrations of nucleation mode (Dp < 25 nm) and fine mode (25 < Dp < 250 nm) particles, and growth rates were analyzed to identify regional nucleation events during November 2005 to September 2007. Shortwave flux from Clouds and Earth's Radiant Energy System (CERES) and aerosol optical depth at 550 nm (AOD, tau550) from Moderate Resolution Imaging Spectroradiometer (MODIS) instruments onboard the Earth Observing System (EOS) Terra satellite were used to estimate SWARF. AOD was highest (0.38 +/- 0.20) in summer (period of highest particle growth rate) and lowest (0.06 +/- 0.05) in winter (period of lowest particle growth rate). The nucleation day SWARF forcing was -24 +/- 11 Wm-2 in summer and -15 +/- 19 Wm-2 in spring. The radiative forcing efficiency was lower (-54 Wm-2, tau550 -1) in summer (period of highest tau550 and organic PM2.5 concentrations) as compared to spring (-93 Wm-2, tau550 -1). The results show that, during spring and summer 2006 and 2007, the radiative forcing efficiency of regionally nucleated aerosols was -73 Wm-2, tau550 -1. Formations of particles during regional nucleation events introduced significant radiative forcing that need to examine for other regions of the globe where intense regional nucleation events occur frequently.

  19. Generalized coherent states related to the associated Bessel functions and Morse potential

    International Nuclear Information System (INIS)

    Mojaveri, B; Amiri Faseghandis, S

    2014-01-01

    Using the associated Bessel functions, a shape-invariant Lie algebra spanned by ladder operators plus the identity operator, is realized. The Hilbert space of the associated Bessel functions, representing the Lie algebra, are established and two kinds of generalized coherent states as an appropriate superposition of these functions are constructed. By implying appropriate similarity transformation on the constructed coherent states, the generalized coherent states for the Morse potential are obtained. By considering some statistical characteristics, it is revealed that the constructed coherent states indeed possess nonclassical features, such as squeezing and sub-Poissonian statistics. (paper)

  20. Estimates of carbon stored in harvested wood products from United States Forest Service's Sierra Nevada Bio-Regional Assessment Area of the Pacific Southwest Region, 1909-2012

    Science.gov (United States)

    Keith Stockmann; Nathaniel Anderson; Jesse Young; Ken Skog; Sean Healey; Dan Loeffler; Edward Butler; J. Greg Jones; James Morrison

    2014-01-01

    Global forests capture and store significant amounts of carbon through photosynthesis. When carbon is removed from forests through harvest, a portion of the harvested carbon is stored in wood products, often for many decades. The United States Forest Service (USFS) and other agencies are interested in accurately accounting for carbon flux associated with harvested wood...

  1. Regional and forest-level estimates of carbon stored in harvested wood products from the United States Forest Service Northern Region, 1906-2010

    Science.gov (United States)

    N. Anderson; J. Young; K. Stockmann; K. Skog; S. Healey; D. Loeffler; J.G. Jones; J. Morrison

    2013-01-01

    Global forests capture and store significant amounts of CO2 through photosynthesis. When carbon is removed from forests through harvest, a portion of the harvested carbon is stored in wood products, often for many decades. The United States Forest Service (USFS) and other agencies are interested in accurately accounting for carbon flux associated with harvested wood...

  2. Energy intensities in Mato Grosso state and in meso-regions; Intensidades energeticas nas mesorregioes de Mato Grosso

    Energy Technology Data Exchange (ETDEWEB)

    Canavarros, Otacilio Borges; Melo, Moises Candido de; Dorileo, Ivo Leandro [Universidade Federal de Mato Grosso (UFMT), Cuiaba, MT (Brazil). Nucleo Interdisciplinar de Estudos em Planejamento Energetico (NIEPE)

    2004-07-01

    This work presents some energetic intensities in Mato Grosso state and in each of its five meso-regions that are in the document produced in 2002 by the NIPE/UFMT (Nucleo Interdisciplinar de Estudos em Planejamento Energetico of the Universidade Federal do Mato Grosso) entitled: 'Energetic Balance of the Mato Grosso and meso-regions: period 1995-2001'. (author)

  3. Atypical energetic particle events observed prior energetic particle enhancements associated with corotating interaction regions

    Science.gov (United States)

    Khabarova, Olga; Malandraki, Olga; Zank, Gary; Jackson, Bernard; Bisi, Mario; Desai, Mihir; Li, Gang; le Roux, Jakobus; Yu, Hsiu-Shan

    2017-04-01

    Recent studies of mechanisms of particle acceleration in the heliosphere have revealed the importance of the comprehensive analysis of stream-stream interactions as well as the heliospheric current sheet (HCS) - stream interactions that often occur in the solar wind, producing huge magnetic cavities bounded by strong current sheets. Such cavities are usually filled with small-scale magnetic islands that trap and re-accelerate energetic particles (Zank et al. ApJ, 2014, 2015; le Roux et al. ApJ, 2015, 2016; Khabarova et al. ApJ, 2015, 2016). Crossings of these regions are associated with unusual variations in the energetic particle flux up to several MeV/nuc near the Earth's orbit. These energetic particle flux enhancements called "atypical energetic particle events" (AEPEs) are not associated with standard mechanisms of particle acceleration. The analysis of multi-spacecraft measurements of energetic particle flux, plasma and the interplanetary magnetic field shows that AEPEs have a local origin as they are observed by different spacecraft with a time delay corresponding to the solar wind propagation from one spacecraft to another, which is a signature of local particle acceleration in the region embedded in expanding and rotating background solar wind. AEPEs are often observed before the arrival of corotating interaction regions (CIRs) or stream interaction regions (SIRs) to the Earth's orbit. When fast solar wind streams catch up with slow solar wind, SIRs of compressed heated plasma or more regular CIRs are created at the leading edge of the high-speed stream. Since coronal holes are often long-lived structures, the same CIR re-appears often for several consecutive solar rotations. At low heliographic latitudes, such CIRs are typically bounded by forward and reverse waves on their leading and trailing edges, respectively, that steepen into shocks at heliocentric distances beyond 1 AU. Energetic ion increases have been frequently observed in association with CIR

  4. Advances in regional crop yield estimation over the United States using satellite remote sensing data

    Science.gov (United States)

    Johnson, D. M.; Dorn, M. F.; Crawford, C.

    2015-12-01

    Since the dawn of earth observation imagery, particularly from systems like Landsat and the Advanced Very High Resolution Radiometer, there has been an overarching desire to regionally estimate crop production remotely. Research efforts integrating space-based imagery into yield models to achieve this need have indeed paralleled these systems through the years, yet development of a truly useful crop production monitoring system has been arguably mediocre in coming. As a result, relatively few organizations have yet to operationalize the concept, and this is most acute in regions of the globe where there are not even alternative sources of crop production data being collected. However, the National Agricultural Statistics Service (NASS) has continued to push for this type of data source as a means to complement its long-standing, traditional crop production survey efforts which are financially costly to the government and create undue respondent burden on farmers. Corn and soybeans, the two largest field crops in the United States, have been the focus of satellite-based production monitoring by NASS for the past decade. Data from the Moderate Resolution Imaging Spectroradiometer (MODIS) has been seen as the most pragmatic input source for modeling yields primarily based on its daily revisit capabilities and reasonable ground sample resolution. The research methods presented here will be broad but provides a summary of what is useful and adoptable with satellite imagery in terms of crop yield estimation. Corn and soybeans will be of particular focus but other major staple crops like wheat and rice will also be presented. NASS will demonstrate that while MODIS provides a slew of vegetation related products, the traditional normalized difference vegetation index (NDVI) is still ideal. Results using land surface temperature products, also generated from MODIS, will also be shown. Beyond the MODIS data itself, NASS research has also focused efforts on understanding a

  5. Epidemiological characterization and risk factors associated with Mycobacterium avium subsp. paratuberculosis infection in dairy goats in the Brazilian semiarid region

    Directory of Open Access Journals (Sweden)

    Theonys Diógenes Freitas

    2015-02-01

    Full Text Available The aim of this investigation was to conduct an epidemiological study and identify risk factors associated with the occurrence of paratuberculosis (Johne’s disease in dairy goats within the semiarid region of Paraíba State. The study was done during the period of March 2009 to July 2011, during which 727 female goats from 86 flocks from the city of Monteiro, Paraíba were investigated. For the serological diagnosis of Mycobacterium avium subsp. paratuberculosis (Map infection indirect ELISA tests (screening and confirmatory were performed. Of the 727 animals used six (0.82% were seropositive at the confirmatory test after screening, and of the 86 flocks six (6.97% presented at least one seropositive animal. In positive flocks the frequency of reactive animals ranged from 5.26% to 16.60%. Risk factors identified were production system (weaning and reproduction (odds ratio = 36.0; 95% CI = 2.6 –486.1; p < 0,001 and absence of technical infrastructure (odds ratio = 54.0; 95% CI = 4.5 –642.9; p < 0,001. It was concluded that Mycobacterium avium subsp. paratuberculosis is present in dairy goat flocks in the region; however, its influence on decrease productivity as well as the risk of transmission to humans through animal products must totally evaluated. Based on the analysis of risk factors, improvements are recommended for the technical infrastructure and the management of breeding goats.

  6. Stream flow regime of springs in the Mantiqueira Mountain Range region, Minas Gerais State

    Directory of Open Access Journals (Sweden)

    Alisson Souza de Oliveira

    2014-09-01

    Full Text Available The stream flow regime of four springs located in the Mantiqueira Mountain Range region (MG was evaluated and correlated to the respective recharge area, relief characteristics, land cover and physical and hydrologic soil characteristics. The streamflow regime was characterized by monitoring of discharges, calculating the surface runoff and specific discharge and by modeling the discharge over the recession period using the Maillet method. As all recharge areas have similar relief the effect of it on the streamflow was not possible to identify. Analysis included determining the effect of drainage area size, soil characteristics and land cover on the indicators of the streamflow regime. Size of the recharge area had a positive influence on the indicators mean discharge and surface runoff volume and on the regulation of the streamflow regime (springs L4 and L1. The spring under the smallest area of influence provided the worst results for the above mentioned indicators (spring L3. The effect of forest cover (natural and planted, associated with soil characteristics, was evidenced by the indicators surface runoff (in depth and specific yield, both independent of the recharge a