WorldWideScience

Sample records for state specific generation

  1. Wind power scenario generation through state-space specifications for uncertainty analysis of wind power plants

    International Nuclear Information System (INIS)

    Díaz, Guzmán; Gómez-Aleixandre, Javier; Coto, José

    2016-01-01

    Highlights: • State space representations for simulating wind power plant output are proposed. • The representation of wind speed in state space allows structural analysis. • The joint model incorporates the temporal and spatial dependence structure. • The models are easily integrable into a backward/forward sweep algorithm. • Results evidence the remarkable differences between joint and marginal models. - Abstract: This paper proposes the use of state space models to generate scenarios for the analysis of wind power plant (WPP) generation capabilities. The proposal is rooted on the advantages that state space models present for dealing with stochastic processes; mainly their structural definition and the use of Kalman filter to naturally tackle some involved operations. The specification proposed in this paper comprises a structured representation of individual Box–Jenkins models, with indications about further improvements that can be easily performed. These marginal models are combined to form a joint model in which the dependence structure is easily handled. Indications about the procedure to calibrate and check the model, as well as a validation of its statistical appropriateness, are provided. Application of the proposed state space models provides insight on the need to properly specify the structural dependence between wind speeds. In this paper the joint and marginal models are smoothly integrated into a backward–forward sweep algorithm to determine the performance indicators (voltages and powers) of a WPP through simulation. As a result, visibly heavy tails emerge in the generated power probability distribution through the use of the joint model—incorporating a detailed description of the dependence structure—in contrast with the normally distributed power yielded by the margin-based model.

  2. Estimating State-Specific Contributions to PM2.5- and O3-Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States.

    Science.gov (United States)

    Penn, Stefani L; Arunachalam, Saravanan; Woody, Matthew; Heiger-Bernays, Wendy; Tripodis, Yorghos; Levy, Jonathan I

    2017-03-01

    Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM 2.5 ) and ozone (O 3 ). Studies to date have not isolated contributing emissions by state of origin (source-state), which is necessary for policy makers to determine efficient strategies to decrease health impacts. In this study, we aimed to estimate health impacts (premature mortalities) attributable to PM 2.5 and O 3 from RC and EGU emissions by precursor species, source sector, and source-state in the continental United States for 2005. We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration-response functions to calculate associated health impacts. We estimated 21,000 premature mortalities per year from EGU emissions, driven by sulfur dioxide emissions forming PM 2.5 . More than half of EGU health impacts are attributable to emissions from eight states with significant coal combustion and large downwind populations. We estimate 10,000 premature mortalities per year from RC emissions, driven by primary PM 2.5 emissions. States with large populations and significant residential wood combustion dominate RC health impacts. Annual mortality risk per thousand tons of precursor emissions (health damage functions) varied significantly across source-states for both source sectors and all precursor pollutants. Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. Citation: Penn SL, Arunachalam S, Woody M, Heiger-Bernays W, Tripodis Y, Levy JI. 2017. Estimating state-specific contributions to PM 2.5 - and O 3 -related health burden from residential combustion and electricity generating unit emissions in the United States. Environ

  3. On-chip generation of heralded photon-number states

    Science.gov (United States)

    Vergyris, Panagiotis; Meany, Thomas; Lunghi, Tommaso; Sauder, Gregory; Downes, James; Steel, M. J.; Withford, Michael J.; Alibart, Olivier; Tanzilli, Sébastien

    2016-10-01

    Beyond the use of genuine monolithic integrated optical platforms, we report here a hybrid strategy enabling on-chip generation of configurable heralded two-photon states. More specifically, we combine two different fabrication techniques, i.e., non-linear waveguides on lithium niobate for efficient photon-pair generation and femtosecond-laser-direct-written waveguides on glass for photon manipulation. Through real-time device manipulation capabilities, a variety of path-coded heralded two-photon states can be produced, ranging from product to entangled states. Those states are engineered with high levels of purity, assessed by fidelities of 99.5 ± 8% and 95.0 ± 8%, respectively, obtained via quantum interferometric measurements. Our strategy therefore stands as a milestone for further exploiting entanglement-based protocols, relying on engineered quantum states, and enabled by scalable and compatible photonic circuits.

  4. Development of synchronous generator saturation model from steady-state operating data

    Energy Technology Data Exchange (ETDEWEB)

    Jadric, Martin; Despalatovic, Marin; Terzic, Bozo [FESB University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, Split (Croatia)

    2010-11-15

    A new method to estimate and model the saturated synchronous reactances of hydroturbine generators from operating data is presented. For the estimation process, measurements of only the generator steady-state variables are required. First, using a specific procedure, the field to armature turns ratio is estimated from measured steady-state variables at constant power generation and various excitation conditions. Subsequently, for each set of steady-state operating data, saturated synchronous reactances are identified. Fitting surfaces, defined as polynomial functions in two variables, are later used to model these saturated reactances. It is shown that the simpler polynomial functions may be used to model saturation at the steady-state than at the dynamic conditions. The developed steady-state model is validated with measurements performed on the 34 MVA hydroturbine generator. (author)

  5. Generation of photon number states

    International Nuclear Information System (INIS)

    Waks, Edo; Diamanti, Eleni; Yamamoto, Yoshihisa

    2006-01-01

    The visible light photon counter (VLPC) has the capability to discriminate photon number states, in contrast to conventional photon counters which can only detect the presence or absence of photons. We use this capability, along with the process of parametric down-conversion, to generate photon number states. We experimentally demonstrate generation of states containing 1, 2, 3 and 4 photons with high fidelity. We then explore the effect the detection efficiency of the VLPC has on the generation rate and fidelity of the created states

  6. Generating and using truly random quantum states in Mathematica

    Science.gov (United States)

    Miszczak, Jarosław Adam

    2012-01-01

    The problem of generating random quantum states is of a great interest from the quantum information theory point of view. In this paper we present a package for Mathematica computing system harnessing a specific piece of hardware, namely Quantis quantum random number generator (QRNG), for investigating statistical properties of quantum states. The described package implements a number of functions for generating random states, which use Quantis QRNG as a source of randomness. It also provides procedures which can be used in simulations not related directly to quantum information processing. Program summaryProgram title: TRQS Catalogue identifier: AEKA_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKA_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 7924 No. of bytes in distributed program, including test data, etc.: 88 651 Distribution format: tar.gz Programming language: Mathematica, C Computer: Requires a Quantis quantum random number generator (QRNG, http://www.idquantique.com/true-random-number-generator/products-overview.html) and supporting a recent version of Mathematica Operating system: Any platform supporting Mathematica; tested with GNU/Linux (32 and 64 bit) RAM: Case dependent Classification: 4.15 Nature of problem: Generation of random density matrices. Solution method: Use of a physical quantum random number generator. Running time: Generating 100 random numbers takes about 1 second, generating 1000 random density matrices takes more than a minute.

  7. Interface state generation after hole injection

    International Nuclear Information System (INIS)

    Zhao, C. Z.; Zhang, J. F.; Groeseneken, G.; Degraeve, R.; Ellis, J. N.; Beech, C. D.

    2001-01-01

    After terminating electrical stresses, the generation of interface states can continue. Our previous work in this area indicates that the interface state generation following hole injection originates from a defect. These defects are inactive in a fresh device, but can be excited by hole injection and then converted into interface states under a positive gate bias after hole injection. There is little information available on these defects. This article investigates how they are formed and attempts to explain why they are sensitive to processing conditions. Roles played by hydrogen and trapped holes will be clarified. A detailed comparison between the interface state generation after hole injection in air and that in forming gas is carried out. Our results show that there are two independent processes for the generation: one is caused by H 2 cracking and the other is not. The rate limiting process for the interface state generation after hole injection is discussed and the relation between the defects responsible for this generation and hole traps is explored. [copyright] 2001 American Institute of Physics

  8. Nonlinear coherent loss for generating non-classical states

    International Nuclear Information System (INIS)

    Mikhalychev, A; Mogilevtsev, D; Kilin, S

    2011-01-01

    Here, we discuss a generation of non-classical states of bosonic mode with the help of artificially designed loss, namely the nonlinear coherent loss. We show how to generate superpositions of Fock states, and how it is possible to 'comb' the initial states leaving only states with certain properties in the resulting superposition (for example, a generation of a superposition of Fock states with odd number of particles). We discuss purity of generated states and estimate maximal achievable generation fidelity.

  9. Generation of Patient-Specific induced Pluripotent Stem Cell from Peripheral Blood Mononuclear Cells by Sendai Reprogramming Vectors.

    Science.gov (United States)

    Quintana-Bustamante, Oscar; Segovia, Jose C

    2016-01-01

    Induced pluripotent stem cells (iPSC) technology has changed preclinical research since their generation was described by Shinya Yamanaka in 2006. iPSCs are derived from somatic cells after being reprogrammed back to an embryonic state by specific combination of reprogramming factors. These reprogrammed cells resemble all the characteristic of embryonic stem cells (ESC). The reprogramming technology is even more valuable to research diseases biology and treatment by opening gene and cell therapies in own patient's iPSC. Patient-specific iPSC can be generated from a large variety of patient cells by any of the myriad of reprogramming platforms described. Here, we describe the generation of patient-specific iPSC from patient peripheral blood mononuclear cells by Sendai Reprogramming vectors.

  10. General linear-optical quantum state generation scheme: Applications to maximally path-entangled states

    International Nuclear Information System (INIS)

    VanMeter, N. M.; Lougovski, P.; Dowling, Jonathan P.; Uskov, D. B.; Kieling, K.; Eisert, J.

    2007-01-01

    We introduce schemes for linear-optical quantum state generation. A quantum state generator is a device that prepares a desired quantum state using product inputs from photon sources, linear-optical networks, and postselection using photon counters. We show that this device can be concisely described in terms of polynomial equations and unitary constraints. We illustrate the power of this language by applying the Groebner-basis technique along with the notion of vacuum extensions to solve the problem of how to construct a quantum state generator analytically for any desired state, and use methods of convex optimization to identify bounds to success probabilities. In particular, we disprove a conjecture concerning the preparation of the maximally path-entangled |n,0>+|0,n> (NOON) state by providing a counterexample using these methods, and we derive a new upper bound on the resources required for NOON-state generation

  11. Parallel Polarization State Generation.

    Science.gov (United States)

    She, Alan; Capasso, Federico

    2016-05-17

    The control of polarization, an essential property of light, is of wide scientific and technological interest. The general problem of generating arbitrary time-varying states of polarization (SOP) has always been mathematically formulated by a series of linear transformations, i.e. a product of matrices, imposing a serial architecture. Here we show a parallel architecture described by a sum of matrices. The theory is experimentally demonstrated by modulating spatially-separated polarization components of a laser using a digital micromirror device that are subsequently beam combined. This method greatly expands the parameter space for engineering devices that control polarization. Consequently, performance characteristics, such as speed, stability, and spectral range, are entirely dictated by the technologies of optical intensity modulation, including absorption, reflection, emission, and scattering. This opens up important prospects for polarization state generation (PSG) with unique performance characteristics with applications in spectroscopic ellipsometry, spectropolarimetry, communications, imaging, and security.

  12. Generating Graphical User Interfaces from Precise Domain Specifications

    OpenAIRE

    Kamil Rybiński; Norbert Jarzębowski; Michał Śmiałek; Wiktor Nowakowski; Lucyna Skrzypek; Piotr Łabęcki

    2014-01-01

    Turning requirements into working systems is the essence of software engineering. This paper proposes automation of one of the aspects of this vast problem: generating user interfaces directly from requirements models. It presents syntax and semantics of a comprehensible yet precise domain specification language. For this language, the paper presents the process of generating code for the user interface elements. This includes model transformation procedures to generate window initiation code...

  13. Quasibound states in graphene quantum-dot nanostructures generated by concentric potential barrier rings

    International Nuclear Information System (INIS)

    Jiang Zhao-Tan; Yu Cheng-Long; Dong Quan-Li

    2012-01-01

    We study the quasibound states in a graphene quantum-dot structure generated by the single-, double-, and triple-barrier electrostatic potentials. It is shown that the strongest quasibound states are mainly determined by the innermost barrier. Specifically, the positions of the quasibound states are determined by the barrier height, the number of the quasibound states is determined by the quantum-dot radius and the angular momentum, and the localization degree of the quasibound states is influenced by the width of the innermost barrier, as well as the outside barriers. Furthermore, according to the study on the double- and triple-barrier quantum dots, we find that an effective way to generate more quasibound states with even larger energy level spacings is to design a quantum dot defined by many concentric barriers with larger barrier-height differences. Last, we extend our results into the quantum dot of many barriers, which gives a complete picture about the formation of the quasibound states in the kind of graphene quantum dot created by many concentric potential barrier rings. (rapid communication)

  14. Generation of Path-Encoded Greenberger-Horne-Zeilinger States

    Science.gov (United States)

    Bergamasco, N.; Menotti, M.; Sipe, J. E.; Liscidini, M.

    2017-11-01

    We study the generation of Greenberger-Horne-Zeilinger (GHZ) states of three path-encoded photons. Inspired by the seminal work of Bouwmeester et al. [Phys. Rev. Lett. 82, 1345 (1999), 10.1103/PhysRevLett.82.1345] on polarization-entangled GHZ states, we find a corresponding path representation for the photon states of an optical circuit, identify the elements required for the state generation, and propose a possible implementation of our strategy. Besides the practical advantage of employing an integrated system that can be fabricated with proven lithographic techniques, our example suggests that it is possible to enhance the generation efficiency by using microring resonators.

  15. Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.

    Directory of Open Access Journals (Sweden)

    Guoshi Li

    2017-10-01

    Full Text Available The thalamus plays a critical role in the genesis of thalamocortical oscillations, yet the underlying mechanisms remain elusive. To understand whether the isolated thalamus can generate multiple distinct oscillations, we developed a biophysical thalamic model to test the hypothesis that generation of and transition between distinct thalamic oscillations can be explained as a function of neuromodulation by acetylcholine (ACh and norepinephrine (NE and afferent synaptic excitation. Indeed, the model exhibited four distinct thalamic rhythms (delta, sleep spindle, alpha and gamma oscillations that span the physiological states corresponding to different arousal levels from deep sleep to focused attention. Our simulation results indicate that generation of these distinct thalamic oscillations is a result of both intrinsic oscillatory cellular properties and specific network connectivity patterns. We then systematically varied the ACh/NE and input levels to generate a complete map of the different oscillatory states and their transitions. Lastly, we applied periodic stimulation to the thalamic network and found that entrainment of thalamic oscillations is highly state-dependent. Our results support the hypothesis that ACh/NE modulation and afferent excitation define thalamic oscillatory states and their response to brain stimulation. Our model proposes a broader and more central role of the thalamus in the genesis of multiple distinct thalamo-cortical rhythms than previously assumed.

  16. Specification, construction, and exact reduction of state transition system models of biochemical processes.

    Science.gov (United States)

    Bugenhagen, Scott M; Beard, Daniel A

    2012-10-21

    Biochemical reaction systems may be viewed as discrete event processes characterized by a number of states and state transitions. These systems may be modeled as state transition systems with transitions representing individual reaction events. Since they often involve a large number of interactions, it can be difficult to construct such a model for a system, and since the resulting state-level model can involve a huge number of states, model analysis can be difficult or impossible. Here, we describe methods for the high-level specification of a system using hypergraphs, for the automated generation of a state-level model from a high-level model, and for the exact reduction of a state-level model using information from the high-level model. Exact reduction is achieved through the automated application to the high-level model of the symmetry reduction technique and reduction by decomposition by independent subsystems, allowing potentially significant reductions without the need to generate a full model. The application of the method to biochemical reaction systems is illustrated by models describing a hypothetical ion-channel at several levels of complexity. The method allows for the reduction of the otherwise intractable example models to a manageable size.

  17. Dynamical generation of maximally entangled states in two identical cavities

    International Nuclear Information System (INIS)

    Alexanian, Moorad

    2011-01-01

    The generation of entanglement between two identical coupled cavities, each containing a single three-level atom, is studied when the cavities exchange two coherent photons and are in the N=2,4 manifolds, where N represents the maximum number of photons possible in either cavity. The atom-photon state of each cavity is described by a qutrit for N=2 and a five-dimensional qudit for N=4. However, the conservation of the total value of N for the interacting two-cavity system limits the total number of states to only 4 states for N=2 and 8 states for N=4, rather than the usual 9 for two qutrits and 25 for two five-dimensional qudits. In the N=2 manifold, two-qutrit states dynamically generate four maximally entangled Bell states from initially unentangled states. In the N=4 manifold, two-qudit states dynamically generate maximally entangled states involving three or four states. The generation of these maximally entangled states occurs rather rapidly for large hopping strengths. The cavities function as a storage of periodically generated maximally entangled states.

  18. State Generation Method for Humanoid Motion Planning Based on Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Xuyang Wang

    2012-05-01

    Full Text Available A new approach to generate the original motion data for humanoid motion planning is presented in this paper. And a state generator is developed based on the genetic algorithm, which enables users to generate various motion states without using any reference motion data. By specifying various types of constraints such as configuration constraints and contact constraints, the state generator can generate stable states that satisfy the constraint conditions for humanoid robots. To deal with the multiple constraints and inverse kinematics, the state generation is finally simplified as a problem of optimizing and searching. In our method, we introduce a convenient mathematic representation for the constraints involved in the state generator, and solve the optimization problem with the genetic algorithm to acquire a desired state. To demonstrate the effectiveness and advantage of the method, a number of motion states are generated according to the requirements of the motion.

  19. State Generation Method for Humanoid Motion Planning Based on Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Xuyang Wang

    2008-11-01

    Full Text Available A new approach to generate the original motion data for humanoid motion planning is presented in this paper. And a state generator is developed based on the genetic algorithm, which enables users to generate various motion states without using any reference motion data. By specifying various types of constraints such as configuration constraints and contact constraints, the state generator can generate stable states that satisfy the constraint conditions for humanoid robots.To deal with the multiple constraints and inverse kinematics, the state generation is finally simplified as a problem of optimizing and searching. In our method, we introduce a convenient mathematic representation for the constraints involved in the state generator, and solve the optimization problem with the genetic algorithm to acquire a desired state. To demonstrate the effectiveness and advantage of the method, a number of motion states are generated according to the requirements of the motion.

  20. Formal specification of a query expression generator using RSL ...

    African Journals Online (AJOL)

    From the specification, an implementation of our generator is generated in C++ using a command within the RSL project support environment that translates RSL to C++. The preliminary results with our generator show that it holds promise as a stand-alone tool as well. (Botswana Journal of Technology: 2002 11(2): 9-17) ...

  1. On-chip generation of high-dimensional entangled quantum states and their coherent control.

    Science.gov (United States)

    Kues, Michael; Reimer, Christian; Roztocki, Piotr; Cortés, Luis Romero; Sciara, Stefania; Wetzel, Benjamin; Zhang, Yanbing; Cino, Alfonso; Chu, Sai T; Little, Brent E; Moss, David J; Caspani, Lucia; Azaña, José; Morandotti, Roberto

    2017-06-28

    Optical quantum states based on entangled photons are essential for solving questions in fundamental physics and are at the heart of quantum information science. Specifically, the realization of high-dimensional states (D-level quantum systems, that is, qudits, with D > 2) and their control are necessary for fundamental investigations of quantum mechanics, for increasing the sensitivity of quantum imaging schemes, for improving the robustness and key rate of quantum communication protocols, for enabling a richer variety of quantum simulations, and for achieving more efficient and error-tolerant quantum computation. Integrated photonics has recently become a leading platform for the compact, cost-efficient, and stable generation and processing of non-classical optical states. However, so far, integrated entangled quantum sources have been limited to qubits (D = 2). Here we demonstrate on-chip generation of entangled qudit states, where the photons are created in a coherent superposition of multiple high-purity frequency modes. In particular, we confirm the realization of a quantum system with at least one hundred dimensions, formed by two entangled qudits with D = 10. Furthermore, using state-of-the-art, yet off-the-shelf telecommunications components, we introduce a coherent manipulation platform with which to control frequency-entangled states, capable of performing deterministic high-dimensional gate operations. We validate this platform by measuring Bell inequality violations and performing quantum state tomography. Our work enables the generation and processing of high-dimensional quantum states in a single spatial mode.

  2. Extinction Generates Outcome-Specific Conditioned Inhibition.

    Science.gov (United States)

    Laurent, Vincent; Chieng, Billy; Balleine, Bernard W

    2016-12-05

    Extinction involves altering a previously established predictive relationship between a cue and its outcome by repeatedly presenting that cue alone. Although it is widely accepted that extinction generates some form of inhibitory learning [1-4], direct evidence for this claim has been lacking, and the nature of the associative changes induced by extinction have, therefore, remained a matter of debate [5-8]. In the current experiments, we used a novel behavioral approach that we recently developed and that provides a direct measure of conditioned inhibition [9] to compare the influence of extinguished and non-extinguished cues on choice between goal-directed actions. Using this approach, we provide direct evidence that extinction generates outcome-specific conditioned inhibition. Furthermore, we demonstrate that this inhibitory learning is controlled by the infralimbic cortex (IL); inactivation of the IL using M4 DREADDs abolished outcome-specific inhibition and rendered the cue excitatory. Importantly, we found that context modulated this inhibition. Outside its extinction context, the cue was excitatory and functioned as a specific predictor of its previously associated outcome, biasing choice toward actions earning the same outcome. In its extinction context, however, the cue acted as a specific inhibitor and biased choice toward actions earning different outcomes. Context modulation of these excitatory and inhibitory memories was mediated by the dorsal hippocampus (HPC), suggesting that the HPC and IL act in concert to control the influence of conditioned inhibitors on choice. These findings demonstrate for the first time that extinction turns a cue into a net inhibitor that can influence choice via counterfactual action-outcome associations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Relational and item-specific influences on generate-recognize processes in recall.

    Science.gov (United States)

    Guynn, Melissa J; McDaniel, Mark A; Strosser, Garrett L; Ramirez, Juan M; Castleberry, Erica H; Arnett, Kristen H

    2014-02-01

    The generate-recognize model and the relational-item-specific distinction are two approaches to explaining recall. In this study, we consider the two approaches in concert. Following Jacoby and Hollingshead (Journal of Memory and Language 29:433-454, 1990), we implemented a production task and a recognition task following production (1) to evaluate whether generation and recognition components were evident in cued recall and (2) to gauge the effects of relational and item-specific processing on these components. An encoding task designed to augment item-specific processing (anagram-transposition) produced a benefit on the recognition component (Experiments 1-3) but no significant benefit on the generation component (Experiments 1-3), in the context of a significant benefit to cued recall. By contrast, an encoding task designed to augment relational processing (category-sorting) did produce a benefit on the generation component (Experiment 3). These results converge on the idea that in recall, item-specific processing impacts a recognition component, whereas relational processing impacts a generation component.

  4. Correlation/Communication complexity of generating bipartite states

    OpenAIRE

    Jain, Rahul; Shi, Yaoyun; Wei, Zhaohui; Zhang, Shengyu

    2012-01-01

    We study the correlation complexity (or equivalently, the communication complexity) of generating a bipartite quantum state $\\rho$. When $\\rho$ is a pure state, we completely characterize the complexity for approximately generating $\\rho$ by a corresponding approximate rank, closing a gap left in Ambainis, Schulman, Ta-Shma, Vazirani and Wigderson (SIAM Journal on Computing, 32(6):1570-1585, 2003). When $\\rho$ is a classical distribution $P(x,y)$, we tightly characterize the complexity of gen...

  5. Generation of picosecond pulsed coherent state superpositions

    DEFF Research Database (Denmark)

    Dong, Ruifang; Tipsmark, Anders; Laghaout, Amine

    2014-01-01

    We present the generation of approximated coherent state superpositions-referred to as Schrodinger cat states-by the process of subtracting single photons from picosecond pulsed squeezed states of light. The squeezed vacuum states are produced by spontaneous parametric down-conversion (SPDC...... which exhibit non-Gaussian behavior. (C) 2014 Optical Society of America...

  6. Distributed Graph-Based State Space Generation

    NARCIS (Netherlands)

    Blom, Stefan; Kant, Gijs; Rensink, Arend; De Lara, J.; Varro, D.

    LTSMIN provides a framework in which state space generation can be distributed easily over many cores on a single compute node, as well as over multiple compute nodes. The tool works on the basis of a vector representation of the states; the individual cores are assigned the task of computing all

  7. Atlas-Based Automatic Generation of Subject-Specific Finite Element Tongue Meshes.

    Science.gov (United States)

    Bijar, Ahmad; Rohan, Pierre-Yves; Perrier, Pascal; Payan, Yohan

    2016-01-01

    Generation of subject-specific 3D finite element (FE) models requires the processing of numerous medical images in order to precisely extract geometrical information about subject-specific anatomy. This processing remains extremely challenging. To overcome this difficulty, we present an automatic atlas-based method that generates subject-specific FE meshes via a 3D registration guided by Magnetic Resonance images. The method extracts a 3D transformation by registering the atlas' volume image to the subject's one, and establishes a one-to-one correspondence between the two volumes. The 3D transformation field deforms the atlas' mesh to generate the subject-specific FE mesh. To preserve the quality of the subject-specific mesh, a diffeomorphic non-rigid registration based on B-spline free-form deformations is used, which guarantees a non-folding and one-to-one transformation. Two evaluations of the method are provided. First, a publicly available CT-database is used to assess the capability to accurately capture the complexity of each subject-specific Lung's geometry. Second, FE tongue meshes are generated for two healthy volunteers and two patients suffering from tongue cancer using MR images. It is shown that the method generates an appropriate representation of the subject-specific geometry while preserving the quality of the FE meshes for subsequent FE analysis. To demonstrate the importance of our method in a clinical context, a subject-specific mesh is used to simulate tongue's biomechanical response to the activation of an important tongue muscle, before and after cancer surgery.

  8. Optical generation of matter qubit graph states

    International Nuclear Information System (INIS)

    Benjamin, S C; Eisert, J; Stace, T M

    2005-01-01

    We present a scheme for rapidly entangling matter qubits in order to create graph states for one-way quantum computing. The qubits can be simple three-level systems in separate cavities. Coupling involves only local fields and a static (unswitched) linear optics network. Fusion of graph-state sections occurs with, in principle, zero probability of damaging the nascent graph state. We avoid the finite thresholds of other schemes by operating on two entangled pairs, so that each generates exactly one photon. We do not require the relatively slow single qubit local flips to be applied during the growth phase: growth of the graph state can then become a purely optical process. The scheme naturally generates graph states with vertices of high degree and so is easily able to construct minimal graph states, with consequent resource savings. The most efficient approach will be to create new graph-state edges even as qubits elsewhere are measured, in a 'just in time' approach. An error analysis indicates that the scheme is relatively robust against imperfections in the apparatus

  9. Generation of distributed W-states over long distances

    Science.gov (United States)

    Li, Yi

    2017-08-01

    Ultra-secure quantum communication between distant locations requires distributed entangled states between nodes. Various methodologies have been proposed to tackle this technological challenge, of which the so-called DLCZ protocol is the most promising and widely adopted scheme. This paper aims to extend this well-known protocol to a multi-node setting where the entangled W-state is generated between nodes over long distances. The generation of multipartite W-states is the foundation of quantum networks, paving the way for quantum communication and distributed quantum computation.

  10. Transire, a Program for Generating Solid-State Interface Structures

    Science.gov (United States)

    2017-09-14

    ARL-TR-8134 ● SEP 2017 US Army Research Laboratory Transire, a Program for Generating Solid-State Interface Structures by...Program for Generating Solid-State Interface Structures by Caleb M Carlin and Berend C Rinderspacher Weapons and Materials Research Directorate, ARL...

  11. How safe is defect specific maintenance of steam generator tubes?

    International Nuclear Information System (INIS)

    Dvorsek, T.; Cizelj, L.

    1995-01-01

    Outside diameter stress corrosion cracking at the tube to tube support plate intersections is assessed in the paper. The impact of defect specific maintenance on steam generator operation safety and reliability was investigated. This was performed by comparing efficiencies of defect specific and traditional maintenance strategy. The efficiency was studied through expected primary-to-secondary leak rate and tube rupture probability in a case of postulated accidental operating conditions, and number of tubes which shall be plugged using both maintenance strategies. In general, the efficiency of specific maintenance is function of particular steam generator and operating cycle. (author)

  12. A multi-state model for the reliability assessment of a distributed generation system via universal generating function

    International Nuclear Information System (INIS)

    Li, Yan-Fu; Zio, Enrico

    2012-01-01

    The current and future developments of electric power systems are pushing the boundaries of reliability assessment to consider distribution networks with renewable generators. Given the stochastic features of these elements, most modeling approaches rely on Monte Carlo simulation. The computational costs associated to the simulation approach force to treating mostly small-sized systems, i.e. with a limited number of lumped components of a given renewable technology (e.g. wind or solar, etc.) whose behavior is described by a binary state, working or failed. In this paper, we propose an analytical multi-state modeling approach for the reliability assessment of distributed generation (DG). The approach allows looking to a number of diverse energy generation technologies distributed on the system. Multiple states are used to describe the randomness in the generation units, due to the stochastic nature of the generation sources and of the mechanical degradation/failure behavior of the generation systems. The universal generating function (UGF) technique is used for the individual component multi-state modeling. A multiplication-type composition operator is introduced to combine the UGFs for the mechanical degradation and renewable generation source states into the UGF of the renewable generator power output. The overall multi-state DG system UGF is then constructed and classical reliability indices (e.g. loss of load expectation (LOLE), expected energy not supplied (EENS)) are computed from the DG system generation and load UGFs. An application of the model is shown on a DG system adapted from the IEEE 34 nodes distribution test feeder.

  13. The development of model generators for specific reactors

    Energy Technology Data Exchange (ETDEWEB)

    Chow, J.C. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2012-07-01

    Authoring reactor models is a routine task for practitioners in nuclear engineering for reactor design, safety analysis, and code validation. The conventional approach is to use a text-editor to either manually manipulate an existing model or to assemble a new model by copying and pasting or direct typing. This approach is error-prone and substantial effort is required for verification. Alternatively, models can be generated programmatically for a specific system via a centralized data source and with rigid algorithms to generate models consistently and efficiently. This approach is demonstrated here for model generators for MCNP and KENO for the ZED-2 reactor. (author)

  14. Generation and storage of quantum states using cold atoms

    DEFF Research Database (Denmark)

    Dantan, Aurelien Romain; Josse, Vincent; Cviklinski, Jean

    2006-01-01

    Cold cesium or rubidium atomic samples have a good potential both for generation and storage of nonclassical states of light. Generation of nonclassical states of light is possible through the high non-linearity of cold atomic samples excited close to a resonance line. Quadrature squeezing, polar...

  15. Generating single-photon catalyzed coherent states with quantum-optical catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xue-xiang, E-mail: xuxuexiang@jxnu.edu.cn [Center for Quantum Science and Technology, Jiangxi Normal University, Nanchang 330022 (China); Yuan, Hong-chun [College of Electrical and Optoelectronic Engineering, Changzhou Institute of Technology, Changzhou 213002 (China)

    2016-07-15

    We theoretically generate single-photon catalyzed coherent states (SPCCSs) by means of quantum-optical catalysis based on the beam splitter (BS) or the parametric amplifier (PA). These states are obtained in one of the BS (or PA) output channels if a coherent state and a single-photon Fock state are present in two input ports and a single photon is registered in the other output port. The success probabilities of the detection (also the normalization factors) are discussed, which is different for BS and PA catalysis. In addition, we prove that the generated states catalyzed by BS and PA devices are actually the same quantum states after analyzing photon number distribution of the SPCCSs. The quantum properties of the SPCCSs, such as sub-Poissonian distribution, anti-bunching effect, quadrature squeezing effect, and the negativity of the Wigner function are investigated in detail. The results show that the SPCCSs are non-Gaussian states with an abundance of nonclassicality. - Highlights: • We generate single-photon catalyzed coherent states with quantum-optical catalysis. • We prove the equivalent effects of the lossless beam splitter and the non-degenerate parametric amplifier. • Some nonclassical properties of the generated states are investigated in detail.

  16. Generation of specific antitumor cytotoxic T-lymphocytes in the monoculture

    International Nuclear Information System (INIS)

    Lupatov, A.Yu.; Brondz, B.D.

    1992-01-01

    A new model for the generation of specific antitumor cytotoxic T-lymphocytes (CTL) was proposed. In contrast to other models, it allows to generate effector CTL without immunization in vitro. For estimation of cytotoxic activity, chromium-51 release assay was used. It has been shown that effector CTL were absent in the lymph nodes in 1-fold as well as 2-fold immunization. Specific CTL were detected only after secondary immunization and subsequent cultivation in vitro. Effector cells had Thy1.2 + , Lyt2 + , L3T4 - phenotypes. Presence in vitro of exogenous IL-2 was needed for the generation of CTL against MX-11 sarcoma but not against EL4 lymphoma. The release of IL-2 from lymphomas cells could stimulate generation of the effector cells through activation of the endogenous production of IL-2, or due to some other factors

  17. Vulnerability-specific stress generation: An examination of negative cognitive and interpersonal styles

    Science.gov (United States)

    Liu, Richard T.; Alloy, Lauren B.; Mastin, Becky M.; Choi, Jimmy Y.; Boland, Elaine M.; Jenkins, Abby L.

    2014-01-01

    Although there is substantial evidence documenting the stress generation effect in depression (i.e., the tendency for depression-prone individuals to experience higher rates of life stress to which they contribute), additional research is required to advance current understanding of the specific types of dependent stress (i.e., events influenced by characteristics and attendant behaviors of the individual) relevant to this effect. The present study tested an extension of the stress generation hypothesis, in which the content of dependent stress that is produced by depression-prone individuals is contingent upon, and matches, the nature of their particular vulnerabilities. This extension was tested within the context of two cognitive models (i.e., hopelessness theory [Abramson, Metalsky, & Alloy, 1989] and Cole’s [1990, 1991] competency-based model) and two interpersonal models (i.e., Swann’s [1987] self-verification theory and Coyne’s [1976] interpersonal theory) of depression. Overall, support was obtained for vulnerability-specific stress generation. Specifically, in analyses across vulnerability domains, evidence of stress-generation specificity was found for all domain-specific cognitive vulnerabilities except self-perceived social competence. The within-domain analyses for cognitive vulnerabilities produced more mixed results, but were largely supportive. Additionally, excessive reassurance-seeking was specifically predictive of dependent stress in the social domain, and moderated, but did not mediate, the relation between negative inferential styles overall and in the interpersonal domain and their corresponding generated stress. Finally, no evidence was found for a stress generation effect with negative feedback-seeking. PMID:24679143

  18. The advantage of hydroelectric generation in Roraima State

    International Nuclear Information System (INIS)

    Martinez, M.L.B.; Violin, A.; Martinez, C.B.; Lima, C.M.B.

    1990-01-01

    In this work a study of the viability of implementation of PCH's in north region of the state of Roraima. Comparisons between hydro and diesel electric generation, are made based in the real generating costs and a conclusion that the hydraulic presents a smaller cost than the diesel generation. (author)

  19. Interoperable domain-specific languages families for code generation

    Czech Academy of Sciences Publication Activity Database

    Malohlava, M.; Plášil, F.; Bureš, Tomáš; Hnětynka, P.

    2013-01-01

    Roč. 43, č. 5 (2013), s. 479-499 ISSN 0038-0644 R&D Projects: GA ČR GD201/09/H057 EU Projects: European Commission(XE) ASCENS 257414 Grant - others:GA AV ČR(CZ) GAP103/11/1489 Program:FP7 Institutional research plan: CEZ:AV0Z10300504 Keywords : code generation * domain specific languages * models reuse * extensible languages * specification * program synthesis Subject RIV: JC - Computer Hardware ; Software Impact factor: 1.148, year: 2013

  20. A Database Approach to Distributed State Space Generation

    NARCIS (Netherlands)

    Blom, Stefan; Lisser, Bert; van de Pol, Jan Cornelis; Weber, M.

    2007-01-01

    We study distributed state space generation on a cluster of workstations. It is explained why state space partitioning by a global hash function is problematic when states contain variables from unbounded domains, such as lists or other recursive datatypes. Our solution is to introduce a database

  1. A Database Approach to Distributed State Space Generation

    NARCIS (Netherlands)

    Blom, Stefan; Lisser, Bert; van de Pol, Jan Cornelis; Weber, M.; Cerna, I.; Haverkort, Boudewijn R.H.M.

    2008-01-01

    We study distributed state space generation on a cluster of workstations. It is explained why state space partitioning by a global hash function is problematic when states contain variables from unbounded domains, such as lists or other recursive datatypes. Our solution is to introduce a database

  2. Generating entangled state of Bose-Einstein condensate using electromagnetically induced transparency

    Science.gov (United States)

    Li, Song-Song

    2018-01-01

    We put forward a scheme on how to generate entangled state of Bose-Einstein condensate (BEC) using electromagnetically induced transparency (EIT). It is shown that we can rapidly generate the entangled state in the dynamical process and the entangled state maintained a long time interval. It is also shown that the better entangled state can be generated by decreasing coupling strengths of two classical laser fields, increasing two-photon detuning and total number of atoms.

  3. Entangled Coherent States Generation in two Superconducting LC Circuits

    International Nuclear Information System (INIS)

    Chen Meiyu; Zhang Weimin

    2008-01-01

    We proposed a novel pure electronic (solid state) device consisting of two superconducting LC circuits coupled to a superconducting flux qubit. The entangled coherent states of the two LC modes is generated through the measurement of the flux qubit states. The interaction of the flux qubit and two LC circuits is controlled by the external microwave control lines. The geometrical structure of the LC circuits is adjustable and makes a strong coupling between them achievable. This entangled coherent state generator can be realized by using the conventional microelectronic fabrication techniques which increases the feasibility of the experiment.

  4. The Elusiveness of Welfare-State Specificity

    Directory of Open Access Journals (Sweden)

    Tahl Kaminer

    2015-12-01

    Full Text Available Review of Architecture and the Welfare State, edited by Mark Swenarton, Tom Avermaete and Dirk van den Heuvel (Oxon and New York: Routledge, 2015.Incomprehensibly, the relation of architecture to society is, on the one hand, a trivial fact, and, on the other, a perplexing assumption. Trivial, because the evidence of the tight relationship is ubiquitous, screaming its existence from the tops of skyscrapers, from the basements of gloomy panopticon prisons, and from the doorsteps of Levittown houses. Perplexing, because, despite of such an abundance of evidence, the actual form of such a relationship remains contested and, mostly, obscure. This review article will interrogate the relation of architecture to society via the recently published anthology Architecture and the Welfare State, edited by Mark Swenarton, Tom Avermaete and Dirk van den Heuvel. The anthology postulates that a rigorous correlation can be established between architectural design and the welfare state. The review article, in turn, posits two questions to the anthology: what is specific about the welfare state which differentiates it from other societies of the era, and how is a rigorous correlation of a specific form of architecture to the welfare state established, beyond limited notions such as zeitgeist? 

  5. Heralded generation of a micro-macro entangled state

    DEFF Research Database (Denmark)

    Andersen, Ulrik Lund; Neergaard-Nielsen, Jonas Schou

    2013-01-01

    Using different optical setups based on squeezed state and photon subtraction we show how optical entanglement between a macroscopic and a microscopic state-the so-called Schro¨dinger cat state or micro-macro state-can be generated. The entangled state is heralded and is thus produced a priori....... Furthermore, we show that the state can be used to map a microscopic qubit onto a macroscopic one thereby linking a qubit processor with a qumode processor....

  6. Oxidation state specific generation of arsines from methylated arsenicals based on L-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer

    Energy Technology Data Exchange (ETDEWEB)

    Matousek, Tomas [Institute of Analytical Chemistry of the ASCR, v.v.i., Videnska 1083, 14220 Prague (Czech Republic)], E-mail: matousek@biomed.cas.cz; Hernandez-Zavala, Araceli [Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7310 (United States); Svoboda, Milan; Langrova, Lenka [Institute of Analytical Chemistry of the ASCR, v.v.i., Videnska 1083, 14220 Prague (Czech Republic); Charles University, Faculty of Science, Albertov 8, 12840 Prague 2 (Czech Republic); Adair, Blakely M. [Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Drobna, Zuzana [Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461 (United States); Thomas, David J. [Pharmacokinetics Branch, Experimental Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Styblo, Miroslav [Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7310 (United States); Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461 (United States); Dedina, Jiri [Institute of Analytical Chemistry of the ASCR, v.v.i., Videnska 1083, 14220 Prague (Czech Republic)

    2008-03-15

    An automated system for hydride generation-cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer is described. Arsines are preconcentrated and separated in a Chromosorb filled U-tube. An automated cryotrapping unit, employing nitrogen gas formed upon heating in the detection phase for the displacement of the cooling liquid nitrogen, has been developed. The conditions for separation of arsines in a Chromosorb filled U-tube have been optimized. A complete separation of signals from arsine, methylarsine, dimethylarsine, and trimethylarsine has been achieved within a 60 s reading window. The limits of detection for methylated arsenicals tested were 4 ng l{sup -1}. Selective hydride generation is applied for the oxidation state specific speciation analysis of inorganic and methylated arsenicals. The arsines are generated either exclusively from trivalent or from both tri- and pentavalent inorganic and methylated arsenicals depending on the presence of L-cysteine as a prereductant and/or reaction modifier. A TRIS buffer reaction medium is proposed to overcome narrow optimum concentration range observed for the L-cysteine modified reaction in HCl medium. The system provides uniform peak area sensitivity for all As species. Consequently, the calibration with a single form of As is possible. This method permits a high-throughput speciation analysis of metabolites of inorganic arsenic in relatively complex biological matrices such as cell culture systems without sample pretreatment, thus preserving the distribution of tri- and pentavalent species.

  7. Generating entangled states of continuous variables via cross-Kerr nonlinearity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Zhiming [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan); Khosa, Ashfaq H [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan); Ikram, Manzoor [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan); Zubairy, M Suhail [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan)

    2007-05-28

    We propose a scheme for generating entanglement of quantum states with continuous variables (coherent states and squeezed vacuum states) of electromagnetical fields. The scheme involves cross-Kerr nonlinearity. It was shown that the cross-Kerr nonlinearity required for generating the superposition and entanglement of squeezed vacuum states is smaller than that required for coherent states. It was also found that the fidelity monotonously decreases with both the increase of the amplitude of the input coherent field and the increase of the deviation of the nonlinear phase shift from {pi}.

  8. Genetic algorithms in teaching artificial intelligence (automated generation of specific algebras)

    Science.gov (United States)

    Habiballa, Hashim; Jendryscik, Radek

    2017-11-01

    The problem of teaching essential Artificial Intelligence (AI) methods is an important task for an educator in the branch of soft-computing. The key focus is often given to proper understanding of the principle of AI methods in two essential points - why we use soft-computing methods at all and how we apply these methods to generate reasonable results in sensible time. We present one interesting problem solved in the non-educational research concerning automated generation of specific algebras in the huge search space. We emphasize above mentioned points as an educational case study of an interesting problem in automated generation of specific algebras.

  9. Generation of cluster states with Josephson charge qubits

    International Nuclear Information System (INIS)

    Zheng, Xiao-Hu; Dong, Ping; Xue, Zheng-Yuan; Cao, Zhuo-Liang

    2007-01-01

    A scheme for the generation of the cluster states based on the Josephson charge qubits is proposed. The two-qubit generation case is introduced first, and then generalized to multi-qubit case. The successful probability and fidelity of current multi-qubit cluster state are both 1.0. The scheme is simple and can be easily manipulated, because any two charge qubits can be selectively and effectively coupled by a common inductance. More manipulations can be realized before decoherence sets in. All the devices in the scheme are well within the current technology

  10. Physical-depth architectural requirements for generating universal photonic cluster states

    Science.gov (United States)

    Morley-Short, Sam; Bartolucci, Sara; Gimeno-Segovia, Mercedes; Shadbolt, Pete; Cable, Hugo; Rudolph, Terry

    2018-01-01

    Most leading proposals for linear-optical quantum computing (LOQC) use cluster states, which act as a universal resource for measurement-based (one-way) quantum computation. In ballistic approaches to LOQC, cluster states are generated passively from small entangled resource states using so-called fusion operations. Results from percolation theory have previously been used to argue that universal cluster states can be generated in the ballistic approach using schemes which exceed the critical threshold for percolation, but these results consider cluster states with unbounded size. Here we consider how successful percolation can be maintained using a physical architecture with fixed physical depth, assuming that the cluster state is continuously generated and measured, and therefore that only a finite portion of it is visible at any one point in time. We show that universal LOQC can be implemented using a constant-size device with modest physical depth, and that percolation can be exploited using simple pathfinding strategies without the need for high-complexity algorithms.

  11. Efficient scheme for three-photon Greenberger–Horne–Zeilinger state generation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Dong [College of Physics Science and Information Engineering, Hebei Normal University, Shijiazhuang, 050024 (China); Department of Basic Curriculum, North China Institute of Science and Technology, Beijing, 101601 (China); Yan, Feng-Li, E-mail: flyan@hebtu.edu.cn [College of Physics Science and Information Engineering, Hebei Normal University, Shijiazhuang, 050024 (China)

    2013-06-17

    We propose an efficient scheme for the generation of three-photon Greenberger–Horne–Zeilinger (GHZ) state with linear optics, nonlinear optics and postselection. Several devices are designed and a two-mode quantum nondemolition detection is introduced to obtain the desired state. It is worth noting that the states which have entanglement in both polarization and spatial degrees of freedom are created in one of the designed setups. The method described in the present scheme can create a large number of three-photon GHZ states in principle. We also discuss an approach to generate the desired GHZ state in the presence of channel noise.

  12. Efficient scheme for three-photon Greenberger–Horne–Zeilinger state generation

    International Nuclear Information System (INIS)

    Ding, Dong; Yan, Feng-Li

    2013-01-01

    We propose an efficient scheme for the generation of three-photon Greenberger–Horne–Zeilinger (GHZ) state with linear optics, nonlinear optics and postselection. Several devices are designed and a two-mode quantum nondemolition detection is introduced to obtain the desired state. It is worth noting that the states which have entanglement in both polarization and spatial degrees of freedom are created in one of the designed setups. The method described in the present scheme can create a large number of three-photon GHZ states in principle. We also discuss an approach to generate the desired GHZ state in the presence of channel noise.

  13. Reduce, reuse, recycle for robust cluster-state generation

    International Nuclear Information System (INIS)

    Horsman, Clare; Brown, Katherine L.; Kendon, Vivien M.; Munro, William J.

    2011-01-01

    Efficient generation of cluster states is crucial for engineering large-scale measurement-based quantum computers. Hybrid matter-optical systems offer a robust, scalable path to this goal. Such systems have an ancilla which acts as a bus connecting the qubits. We show that by generating the cluster in smaller sections of interlocking bricks, reusing one ancilla per brick, the cluster can be produced with maximal efficiency, requiring fewer than half the operations compared with no bus reuse. By reducing the time required to prepare sections of the cluster, bus reuse more than doubles the size of the computational workspace that can be used before decoherence effects dominate. A row of buses in parallel provides fully scalable cluster-state generation requiring only 20 controlled-phase gates per bus use.

  14. Millennials at Work: Investigating the Specificity of Generation Y versus Other Generations

    Directory of Open Access Journals (Sweden)

    Florina PÎNZARU

    2016-06-01

    Full Text Available The present study intends to discuss the psychological profile of Generation Y versus other generations.The differences between Millennials and other generations are addressed in terms of values, personality characteristics, and reactions under stress. The topicality and relevance of the research theme are supported by the fact that most of the people who are currently employed in companies all over the world are members of the Generation Y. This situation requires a proper investigation of the characteristics and specificity of the so-called Millennials with a view to provide organizations with pertinent inputs for designing well-informed policies and for smoothly integrating Millennials in the workplace. To this end, Hogan Assessments personality inventories were applied online to more than 1000 persons from Generation Y (up to 29 years old and more than 3000 persons from other generations (above 29 years old. Among others, the findings show that Millennials are motivated by recognition, public acknowledgment, instant and frequent positive feedback and gratification. As they need balance between personal and professional life, as well as a comfortable environment, they require a flexible work schedule, resent staying after hours. Being motivated to become part of various social networks, work in various teams, Millennials are able to easily find satisfaction in missions that involve interactions with new persons coming from different cultures and geographical areas. They are motivated by work in a nonconformist environment without strict rules and traditional work approaches, they tend to challenge the status quo and they will not be patient to keep the same job many years.

  15. Error free physically unclonable function with programmed resistive random access memory using reliable resistance states by specific identification-generation method

    Science.gov (United States)

    Tseng, Po-Hao; Hsu, Kai-Chieh; Lin, Yu-Yu; Lee, Feng-Min; Lee, Ming-Hsiu; Lung, Hsiang-Lan; Hsieh, Kuang-Yeu; Chung Wang, Keh; Lu, Chih-Yuan

    2018-04-01

    A high performance physically unclonable function (PUF) implemented with WO3 resistive random access memory (ReRAM) is presented in this paper. This robust ReRAM-PUF can eliminated bit flipping problem at very high temperature (up to 250 °C) due to plentiful read margin by using initial resistance state and set resistance state. It is also promised 10 years retention at the temperature range of 210 °C. These two stable resistance states enable stable operation at automotive environments from -40 to 125 °C without need of temperature compensation circuit. The high uniqueness of PUF can be achieved by implementing a proposed identification (ID)-generation method. Optimized forming condition can move 50% of the cells to low resistance state and the remaining 50% remain at initial high resistance state. The inter- and intra-PUF evaluations with unlimited separation of hamming distance (HD) are successfully demonstrated even under the corner condition. The number of reproduction was measured to exceed 107 times with 0% bit error rate (BER) at read voltage from 0.4 to 0.7 V.

  16. Dynamic generation of light states with discrete symmetries

    Science.gov (United States)

    Cordero, S.; Nahmad-Achar, E.; Castaños, O.; López-Peña, R.

    2018-01-01

    A dynamic procedure is established within the generalized Tavis-Cummings model to generate light states with discrete point symmetries, given by the cyclic group Cn. We consider arbitrary dipolar coupling strengths of the atoms with a one-mode electromagnetic field in a cavity. The method uses mainly the matter-field entanglement properties of the system, which can be extended to any number of three-level atoms. An initial state constituted by the superposition of two states with definite total excitation numbers, |ψ〉 M1,and |ψ〉 M 2, is considered. It can be generated by the proper selection of the time of flight of an atom passing through the cavity. We demonstrate that the resulting Husimi function of the light is invariant under cyclic point transformations of order n =| M1-M2| .

  17. Specification of steam generator, condenser and regenerative heat exchanger materials for nuclear applications

    International Nuclear Information System (INIS)

    Jovasevic, J.V.; Stefanovic, V.M.; Spasic, Z.LJ.

    1977-01-01

    The basic standards specifications of materials for nuclear applications are selected. Seamless Ni-Cr-Fe alloy Tubes (Inconel-600) for steam generators, condensers and other heat exchangers can be employed instead of austenitic stainless steal or copper alloys tubes; supplementary requirements for these materials are given. Specifications of Ni-Cr-Fe alloy plate, sheet and strip for steam generator lower sub-assembly, U-bend seamless copper-alloy tubes for heat exchanger and condensers are also presented. At the end, steam generator channel head material is proposed in the specification for carbon-steel castings suitable for welding

  18. Generation of three-qubit Greenberger-Horne-Zeilinger states of superconducting qubits by using dressed states

    Science.gov (United States)

    Zhang, Xu; Chen, Ye-Hong; Shi, Zhi-Cheng; Shan, Wu-Jiang; Song, Jie; Xia, Yan

    2017-12-01

    Combining the advantages of the dressed states and superconducting quantum interference device (SQUID) qubits, we propose an efficient scheme to generate Greenberger-Horne-Zeilinger (GHZ) states for three SQUID qubits. Firstly, we elaborate how to generate GHZ states of three SQUID qubits by choosing a set of dressed states suitably. Then, we compare the scheme by using dressed states with that via the adiabatic passage. Lastly, the influence of various decoherence factors, such as cavity decay, spontaneous emission and dephasing, is analyzed numerically. All of the results show that the GHZ state can be obtained fast and with high fidelity and that the present scheme is robust against the cavity decay and spontaneous emission. In addition, our scheme is more stable against the dephasing than the adiabatic scheme.

  19. Formal Specification Based Automatic Test Generation for Embedded Network Systems

    Directory of Open Access Journals (Sweden)

    Eun Hye Choi

    2014-01-01

    Full Text Available Embedded systems have become increasingly connected and communicate with each other, forming large-scaled and complicated network systems. To make their design and testing more reliable and robust, this paper proposes a formal specification language called SENS and a SENS-based automatic test generation tool called TGSENS. Our approach is summarized as follows: (1 A user describes requirements of target embedded network systems by logical property-based constraints using SENS. (2 Given SENS specifications, test cases are automatically generated using a SAT-based solver. Filtering mechanisms to select efficient test cases are also available in our tool. (3 In addition, given a testing goal by the user, test sequences are automatically extracted from exhaustive test cases. We’ve implemented our approach and conducted several experiments on practical case studies. Through the experiments, we confirmed the efficiency of our approach in design and test generation of real embedded air-conditioning network systems.

  20. Generation, concentration and purification for ionic entangled states

    International Nuclear Information System (INIS)

    Yang Ming; Cao Zhuoliang

    2007-01-01

    In cavity QED, the atoms would be sent through the sequential arrays of cavities for the generation of multi-cavity entanglement, or several atoms would be sent into the same cavity mode one bye one for the generation of multi-atom entanglement. The complexity of these processes will impose limitations on the experimental feasibility of it. So, following our previous publication [International Journal Of Quantum Information 2, 231 (2004)] we will propose an alternative scheme for the preparation of multi-cavity W state via cavity QED, which uses the geometrical method to do what other authors have proposed previously using sequential arrays of cavities. Due to the impossibility that one quantum system can be isolated from the environment absolutely, the entanglement of the entangled objects will decrease exponentially with the propagating distance of the objects, and the practically available quantum entangled states are all non-maximally entangled states or the more general case--mixed states. Following our previous publications [Phys. Rev. A 72, 042307 (2005), ibid. 71, 012308 (2005)], we will propose an entanglement generation, concentration and purification scheme for atomic or ionic system, which is mainly based on Cavity QED and linear optical elements. This purification process avoids the controlled-NOT (C-NOT) operations needed in the original purification protocol, which simplifies the whole purification process

  1. An eFTD-VP framework for efficiently generating patient-specific anatomically detailed facial soft tissue FE mesh for craniomaxillofacial surgery simulation.

    Science.gov (United States)

    Zhang, Xiaoyan; Kim, Daeseung; Shen, Shunyao; Yuan, Peng; Liu, Siting; Tang, Zhen; Zhang, Guangming; Zhou, Xiaobo; Gateno, Jaime; Liebschner, Michael A K; Xia, James J

    2018-04-01

    Accurate surgical planning and prediction of craniomaxillofacial surgery outcome requires simulation of soft tissue changes following osteotomy. This can only be achieved by using an anatomically detailed facial soft tissue model. The current state-of-the-art of model generation is not appropriate to clinical applications due to the time-intensive nature of manual segmentation and volumetric mesh generation. The conventional patient-specific finite element (FE) mesh generation methods are to deform a template FE mesh to match the shape of a patient based on registration. However, these methods commonly produce element distortion. Additionally, the mesh density for patients depends on that of the template model. It could not be adjusted to conduct mesh density sensitivity analysis. In this study, we propose a new framework of patient-specific facial soft tissue FE mesh generation. The goal of the developed method is to efficiently generate a high-quality patient-specific hexahedral FE mesh with adjustable mesh density while preserving the accuracy in anatomical structure correspondence. Our FE mesh is generated by eFace template deformation followed by volumetric parametrization. First, the patient-specific anatomically detailed facial soft tissue model (including skin, mucosa, and muscles) is generated by deforming an eFace template model. The adaptation of the eFace template model is achieved by using a hybrid landmark-based morphing and dense surface fitting approach followed by a thin-plate spline interpolation. Then, high-quality hexahedral mesh is constructed by using volumetric parameterization. The user can control the resolution of hexahedron mesh to best reflect clinicians' need. Our approach was validated using 30 patient models and 4 visible human datasets. The generated patient-specific FE mesh showed high surface matching accuracy, element quality, and internal structure matching accuracy. They can be directly and effectively used for clinical

  2. State-to-State Mode Specificity: Energy Sequestration and Flow Gated by Transition State.

    Science.gov (United States)

    Zhao, Bin; Sun, Zhigang; Guo, Hua

    2015-12-23

    Energy flow and sequestration at the state-to-state level are investigated for a prototypical four-atom reaction, H2 + OH → H + H2O, using a transition-state wave packet (TSWP) method. The product state distribution is found to depend strongly on the reactant vibrational excitation, indicating mode specificity at the state-to-state level. From a local-mode perspective, it is shown that the vibrational excitation of the H2O product derives from two different sources, one attributable to the energy flow along the reaction coordinate into the newly formed OH bond and the other due to the sequestration of the vibrational energy in the OH spectator moiety during the reaction. The analysis provided a unified interpretation of some seemingly contradicting experimental observations. It is further shown that the transfer of vibrational energy from the OH reactant to H2O product is gated by the transition state, accomplished coherently by multiple TSWPs with the corresponding OH vibrational excitation.

  3. Optically isolated, 2 kHz repetition rate, 4 kV solid-state pulse trigger generator.

    Science.gov (United States)

    Barnett, D H; Parson, J M; Lynn, C F; Kelly, P M; Taylor, M; Calico, S; Scott, M C; Dickens, J C; Neuber, A A; Mankowski, J J

    2015-03-01

    This paper presents the design and operation characteristics of a solid-state high voltage pulse generator. Its primary utilization is aimed at triggering a gaseous spark gap with high repeatability. Specifically, the trigger generator is designed to achieve a risetime on the order of 0.1 kV/ns to trigger the first stage, trigatron spark gap of a 10-stage, 500 kV Marx generator. The major design components are comprised of a 60 W constant current DC-DC converter for high voltage charging, a single 4 kV thyristor, a step-up pulse transformer, and magnetic switch for pulse steepening. A risetime of <30 ns and pulse magnitude of 4 kV is achieved matching the simulated performance of the design.

  4. Application of a path sensitizing method on automated generation of test specifications for control software

    International Nuclear Information System (INIS)

    Morimoto, Yuuichi; Fukuda, Mitsuko

    1995-01-01

    An automated generation method for test specifications has been developed for sequential control software in plant control equipment. Sequential control software can be represented as sequential circuits. The control software implemented in a control equipment is designed from these circuit diagrams. In logic tests of VLSI's, path sensitizing methods are widely used to generate test specifications. But the method generates test specifications at a single time only, and can not be directly applied to sequential control software. The basic idea of the proposed method is as follows. Specifications of each logic operator in the diagrams are defined in the software design process. Therefore, test specifications of each operator in the control software can be determined from these specifications, and validity of software can be judged by inspecting all of the operators in the logic circuit diagrams. Candidates for sensitized paths, on which test data for each operator propagates, can be generated by the path sensitizing method. To confirm feasibility of the method, it was experimentally applied to control software in digital control equipment. The program could generate test specifications exactly, and feasibility of the method was confirmed. (orig.) (3 refs., 7 figs.)

  5. Generating grid states from Schrödinger-cat states without postselection

    Science.gov (United States)

    Weigand, Daniel J.; Terhal, Barbara M.

    2018-02-01

    Grid (or comb) states are an interesting class of bosonic states introduced by Gottesman, Kitaev, and Preskill [D. Gottesman, A. Kitaev, and J. Preskill, Phys. Rev. A 64, 012310 (2001), 10.1103/PhysRevA.64.012310] to encode a qubit into an oscillator. A method to generate or "breed" a grid state from Schrödinger cat states using beam splitters and homodyne measurements is known [H. M. Vasconcelos, L. Sanz, and S. Glancy, Opt. Lett. 35, 3261 (2010), 10.1364/OL.35.003261], but this method requires postselection. In this paper we show how postprocessing of the measurement data can be used to entirely remove the need for postselection, making the scheme much more viable. We bound the asymptotic behavior of the breeding procedure and demonstrate the efficacy of the method numerically.

  6. Bound states in the continuum generated by supersymmetric quantum mechanics and phase rigidity of the corresponding wavefunctions

    International Nuclear Information System (INIS)

    Demić, Aleksandar; Milanović, Vitomir; Radovanović, Jelena

    2015-01-01

    Supersymmetric quantum mechanics (SUSYQM) is a method that can be used for generating complex potentials with entirely real spectrum with bound states in the continuum (BIC). These complex potentials are isospectral with the initial one, but SUSYQM method adds discrete BIC's at selected energies. Corresponding wavefunctions created by SUSYQM are biorthogonal and complex, hence we can discuss their phase rigidity and illustrate the application of SUSYQM on the examples of three specific potential profiles (free electron, negative Dirac potential and quantum well with infinite walls). - Highlights: • We present SUSYQM method for generating complex potentials with entirely real spectrum. • Phase rigidity and normalizability of wavefunctions in complex potential is discussed. • Numerical application is performed on three specific potential profiles.

  7. Resource-efficient generation of linear cluster states by linear optics with postselection

    International Nuclear Information System (INIS)

    Uskov, D B; Alsing, P M; Fanto, M L; Szep, A; Smith, A M; Kaplan, L; Kim, R

    2015-01-01

    We report on theoretical research in photonic cluster-state computing. Finding optimal schemes of generating non-classical photonic states is of critical importance for this field as physically implementable photon–photon entangling operations are currently limited to measurement-assisted stochastic transformations. A critical parameter for assessing the efficiency of such transformations is the success probability of a desired measurement outcome. At present there are several experimental groups that are capable of generating multi-photon cluster states carrying more than eight qubits. Separate photonic qubits or small clusters can be fused into a single cluster state by a probabilistic optical CZ gate conditioned on simultaneous detection of all photons with 1/9 success probability for each gate. This design mechanically follows the original theoretical scheme of cluster state generation proposed more than a decade ago by Raussendorf, Browne and Briegel. The optimality of the destructive CZ gate in application to linear optical cluster state generation has not been analyzed previously. Our results reveal that this method is far from the optimal one. Employing numerical optimization we have identified that the maximal success probability of fusing n unentangled dual-rail optical qubits into a linear cluster state is equal to (1/2) n−1 ; an m-tuple of photonic Bell pair states, commonly generated via spontaneous parametric down-conversion, can be fused into a single cluster with the maximal success probability of (1/4) m−1 . (paper)

  8. Multiple electron generation in a sea of electronic states

    Science.gov (United States)

    Witzel, Wayne; Shabaev, Andrew; Efros, Alexander; Hellberg, Carl; Verne, Jacobs

    2009-03-01

    In traditional bulk semiconductor photovoltaics (PVs), each photon may excite a single electron-hole, wasting excess energy beyond the band-gap as heat. In nanocrystals, multiple excitons can be generated from a single photon, enhancing the PV current. Multiple electron generation (MEG) may result from Coulombic interactions of the confined electrons. Previous investigations have been based on incomplete or over-simplified electronic-state representations. We present results of quantum simulations that include hundreds of thousands of configuration states and show how the complex dynamics, even in a closed electronic system, yields a saturated MEG effect on a femtosecond timescale. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  9. Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states.

    Science.gov (United States)

    Takeuchi, Hikaru; Taki, Yasuyuki; Sekiguchi, Atsushi; Nouchi, Rui; Kotozaki, Yuka; Nakagawa, Seishu; Miyauchi, Carlos Makoto; Iizuka, Kunio; Yokoyama, Ryoichi; Shinada, Takamitsu; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Kunitoki, Keiko; Sassa, Yuko; Kawashima, Ryuta

    2017-03-01

    Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.

  10. Pseudo-random number generation using a 3-state cellular automaton

    Science.gov (United States)

    Bhattacharjee, Kamalika; Paul, Dipanjyoti; Das, Sukanta

    This paper investigates the potentiality of pseudo-random number generation of a 3-neighborhood 3-state cellular automaton (CA) under periodic boundary condition. Theoretical and empirical tests are performed on the numbers, generated by the CA, to observe the quality of it as pseudo-random number generator (PRNG). We analyze the strength and weakness of the proposed PRNG and conclude that the selected CA is a good random number generator.

  11. State-space modeling of the radio frequency inductively-coupled plasma generator

    International Nuclear Information System (INIS)

    Dewangan, Rakesh Kumar; Punjabi, Sangeeta B; Mangalvedekar, H A; Lande, B K; Joshi, N K; Barve, D N

    2010-01-01

    Computational fluid dynamics models of RF-ICP are useful in understanding the basic transport phenomenon in an ICP torch under a wide variety of operating conditions. However, these models lack the ability to evaluate the effects of the plasma condition on the RF generator. In this paper, simulation of an induction plasma generator has been done using state space modelling by considering inductively coupled plasma as a part of RF network .The time dependent response of the RF-ICP generator circuit to given input excitation has been computed by extracting the circuit's state-space variables and their constraint matrices. MATLAB 7.1 software has been used to solve the state equations. The values of RF coil current, frequency and plasma power has been measured experimentally also at different plate bias voltage. The simulated model is able to predict RF coil current, frequency, plasma power, overall efficiency of the generator. The simulated and measured values are in agreement with each other. This model can prove useful as a design tool for the Induction plasma generator.

  12. A Monte Carlo program for generating hadronic final states

    International Nuclear Information System (INIS)

    Angelini, L.; Pellicoro, M.; Nitti, L.; Preparata, G.; Valenti, G.

    1991-01-01

    FIRST is a computer program to generate final states from high energy hadronic interactions using the Monte Carlo technique. It is based on a theoretical model in which the high degree of universality in such interactions is related with the existence of highly excited quark-antiquark bound states, called fire-strings. The program handles the decay of both fire-strings and unstable particles produced in the intermediate states. (orig.)

  13. Graph state generation with noisy mirror-inverting spin chains

    International Nuclear Information System (INIS)

    Clark, Stephen R; Klein, Alexander; Bruderer, Martin; Jaksch, Dieter

    2007-01-01

    We investigate the influence of noise on a graph state generation scheme which exploits a mirror inverting spin chain. Within this scheme the spin chain is used repeatedly as an entanglement bus (EB) to create multi-partite entanglement. The noise model we consider comprises of each spin of this EB being exposed to independent local noise which degrades the capabilities of the EB. Here we concentrate on quantifying its performance as a single-qubit channel and as a mediator of a two-qubit entangling gate, since these are basic operations necessary for graph state generation using the EB. In particular, for the single-qubit case we numerically calculate the average channel fidelity and whether the channel becomes entanglement breaking, i.e. expunges any entanglement the transferred qubit may have with other external qubits. We find that neither local decay nor dephasing noise cause entanglement breaking. This is in contrast to local thermal and depolarizing noise where we determine a critical length and critical noise coupling, respectively, at which entanglement breaking occurs. The critical noise coupling for local depolarizing noise is found to exhibit a power-law dependence on the chain length. For two-qubits we similarly compute the average gate fidelity and whether the ability for this gate to create entanglement is maintained. The concatenation of these noisy gates for the construction of a five-qubit linear cluster state and a Greenberger-Horne-Zeilinger state indicates that the level of noise that can be tolerated for graph state generation is tightly constrained

  14. Generation and utilization of knowledge concerning state change propagation using plant design information

    International Nuclear Information System (INIS)

    Nishizawa, Yasuo; Nagaoka, Yukio; Sato, Takao; Matsuki, Tsutomu.

    1992-01-01

    A method of knowledge generation and utilization using design information is described. This method is used to generate rules concerned with propagation of state change in a plant due to equipment manipulation or anomaly. The rules describe macroscopic behavior of plant subsystems consisting of many devices, and are used for high speed information processing in expert systems for plant diagnosis, maintenance, etc. Knowledge generation is comprised of two steps. In the first step, the changes of state values are propagated according to connectivity between devices and the input-output relationships of the devices. In the second step, the input change, output change of plant subsystems, and other information are edited according to the results of state change propagation, and rules for state change propagation are generated. By using these rules, the simulation of state change propagation can be accelerated about 10 times compared with the case of device level propagation. The method of knowledge generation has been applied to the inference system in a maintenance work scheduling system and a new-type expert system was realized. It grows by generating rules for problem solving and by expanding its knowledge base by itself. (author)

  15. Generation of Symmetric Dicke States of Remote Qubits with Linear Optics

    International Nuclear Information System (INIS)

    Thiel, C.; Zanthier, J. von; Bastin, T.; Solano, E.; Agarwal, G. S.

    2007-01-01

    We propose a method for generating all symmetric Dicke states, either in the long-lived internal levels of N massive particles or in the polarization degrees of freedom of photonic qubits, using linear optical tools only. By means of a suitable multiphoton detection technique, erasing Welcher-Weg information, our proposed scheme allows the generation and measurement of an important class of entangled multiqubit states

  16. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.

    Science.gov (United States)

    Sabharwal, Priyanka; Lee, Changhee; Park, Sungjin; Rao, Meenakshi; Sockanathan, Shanthini

    2011-09-22

    The specification of spinal interneuron and motor neuron identities initiates within progenitor cells, while motor neuron subtype diversification is regulated by hierarchical transcriptional programs implemented postmitotically. Here we find that mice lacking GDE2, a six-transmembrane protein that triggers motor neuron generation, exhibit selective losses of distinct motor neuron subtypes, specifically in defined subsets of limb-innervating motor pools that correlate with the loss of force-generating alpha motor neurons. Mechanistically, GDE2 is expressed by postmitotic motor neurons but utilizes extracellular glycerophosphodiester phosphodiesterase activity to induce motor neuron generation by inhibiting Notch signaling in neighboring motor neuron progenitors. Thus, neuronal GDE2 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation, implying that subtype specification initiates within motor neuron progenitor populations prior to their differentiation into postmitotic motor neurons. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. Generation of the reciprocal-binomial state for optical fields

    International Nuclear Information System (INIS)

    Valverde, C.; Avelar, A.T.; Baseia, B.; Malbouisson, J.M.C.

    2003-01-01

    We compare the efficiencies of two interesting schemes to generate truncated states of the light field in running modes, namely the 'quantum scissors' and the 'beam-splitter array' schemes. The latter is applied to create the reciprocal-binomial state as a travelling wave, required to implement recent experimental proposals of phase-distribution determination and of quantum lithography

  18. High-Power, Solid-State, Deep Ultraviolet Laser Generation

    Directory of Open Access Journals (Sweden)

    Hongwen Xuan

    2018-02-01

    Full Text Available At present, deep ultraviolet (DUV lasers at the wavelength of fourth harmonics of 1 μm (266 nm/258 nm and at the wavelength of 193 nm are widely utilized in science and industry. We review the generation of these DUV lasers by nonlinear frequency conversion processes using solid-state/fiber lasers as the fundamental frequency. A DUV laser at 258 nm by fourth harmonics generation (FHG could achieve an average power of 10 W with a beam quality of M2 < 1.5. Moreover, 1 W of average power at 193 nm was obtained by sum-frequency generation (SFG. A new concept of 193-nm DUV laser generation by use of the diamond Raman laser is also introduced. A proof-of-principle experiment of the diamond Raman laser is reported with the conversion efficiency of 23% from the pump to the second Stokes wavelength, which implies the potential to generate a higher power 193 nm DUV laser in the future.

  19. Effect of State-Specific Factors on Acquisition Path Ranking

    International Nuclear Information System (INIS)

    Vincze, A.; Nemeth, A.

    2015-01-01

    The ''directed graph analysis'' has been shown to be a promising methodology to implement acquisition path analysis by the IAEA to support the State evaluation process. Based on this methodology a material flow network model has been developed under the Hungarian Support Programme to the IAEA, in which materials in different chemical and physical form can flow through pipes representing declared processes, material transports, diversions or undeclared processes. The ranking of the resulting acquisition paths of the analysis is a key step to facilitate the determination of technical objectives and the planning of safeguards implementation on State-level. These are determined by the attributes of the processes included into the graph and different state-specific factors. In this paper different set of attributes, State-specific factors and their functional combination will be tested for hypothetical case studies. (author)

  20. Facial Expression Generation from Speaker's Emotional States in Daily Conversation

    Science.gov (United States)

    Mori, Hiroki; Ohshima, Koh

    A framework for generating facial expressions from emotional states in daily conversation is described. It provides a mapping between emotional states and facial expressions, where the former is represented by vectors with psychologically-defined abstract dimensions, and the latter is coded by the Facial Action Coding System. In order to obtain the mapping, parallel data with rated emotional states and facial expressions were collected for utterances of a female speaker, and a neural network was trained with the data. The effectiveness of proposed method is verified by a subjective evaluation test. As the result, the Mean Opinion Score with respect to the suitability of generated facial expression was 3.86 for the speaker, which was close to that of hand-made facial expressions.

  1. Generation of entangled coherent states for distant Bose-Einstein condensates via electromagnetically induced transparency

    International Nuclear Information System (INIS)

    Kuang, L.-M.; Chen Zengbing; Pan Jianwei

    2007-01-01

    We propose a method to generate entangled coherent states between two spatially separated atomic Bose-Einstein condensates (BECs) via the technique of electromagnetically induced transparency (EIT). Two strong coupling laser beams and two entangled probe laser beams are used to cause two distant BECs to be in EIT states and to generate an atom-photon entangled state between probe lasers and distant BECs. The two BECs are initially in unentangled product coherent states while the probe lasers are initially in an entangled state. Entangled states of two distant BECs can be created through the performance of projective measurements upon the two outgoing probe lasers under certain conditions. Concretely, we propose two protocols to show how to generate entangled coherent states of the two distant BECs. One is a single-photon scheme in which an entangled single-photon state is used as the quantum channel to generate entangled distant BECs. The other is a multiphoton scheme where an entangled coherent state of the probe lasers is used as the quantum channel. Additionally, we also obtain some atom-photon entangled states of particular interest such as entangled states between a pair of optical Bell states (or quasi-Bell-states) and a pair of atomic entangled coherent states (or quasi-Bell-states)

  2. Compliance uncertainty of diameter characteristic in the next-generation geometrical product specifications and verification

    International Nuclear Information System (INIS)

    Lu, W L; Jiang, X; Liu, X J; Xu, Z G

    2008-01-01

    Compliance uncertainty is one of the most important elements in the next-generation geometrical product specifications and verification (GPS). It consists of specification uncertainty, method uncertainty and implementation uncertainty, which are three of the four fundamental uncertainties in the next-generation GPS. This paper analyzes the key factors that influence compliance uncertainty and then proposes a procedure to manage the compliance uncertainty. A general model on evaluation of compliance uncertainty has been devised and a specific formula for diameter characteristic has been derived based on this general model. The case study was conducted and it revealed that the completeness of currently dominant diameter characteristic specification needs to be improved

  3. Quantum coherence generated by interference-induced state selectiveness

    OpenAIRE

    Garreau, Jean Claude

    2001-01-01

    The relations between quantum coherence and quantum interference are discussed. A general method for generation of quantum coherence through interference-induced state selection is introduced and then applied to `simple' atomic systems under two-photon transitions, with applications in quantum optics and laser cooling.

  4. Generation of Attosecond Light Pulses from Gas and Solid State Media

    Directory of Open Access Journals (Sweden)

    Stefanos Chatziathanasiou

    2017-03-01

    Full Text Available Real-time observation of ultrafast dynamics in the microcosm is a fundamental approach for understanding the internal evolution of physical, chemical and biological systems. Tools for tracing such dynamics are flashes of light with duration comparable to or shorter than the characteristic evolution times of the system under investigation. While femtosecond (fs pulses are successfully used to investigate vibrational dynamics in molecular systems, real time observation of electron motion in all states of matter requires temporal resolution in the attosecond (1 attosecond (asec = 10−18 s time scale. During the last decades, continuous efforts in ultra-short pulse engineering led to the development of table-top sources which can produce asec pulses. These pulses have been synthesized by using broadband coherent radiation in the extreme ultraviolet (XUV spectral region generated by the interaction of matter with intense fs pulses. Here, we will review asec pulses generated by the interaction of gas phase media and solid surfaces with intense fs IR laser fields. After a brief overview of the fundamental process underlying the XUV emission form these media, we will review the current technology, specifications and the ongoing developments of such asec sources.

  5. Origin of interface states and oxide charges generated by ionizing radiation

    International Nuclear Information System (INIS)

    Sah, C.T.

    1976-01-01

    The randomly located trivalent silicon atoms are shown to account for the thermally generated interface states at the SiO 2 -Si interface. The interface state density is greatly reduced in water containing ambients at low temperatures (450 0 C) by forming trivalent silicon hydroxide bonds. Interface states are regenerated when the /triple bond/Si-OH bonds are broken by ionizing radiation and the OH ions are drifted away. In the bulk of the oxide film, the trivalent silicon and the interstitial oxygen donor centers are shown to be responsible for the heat and radiation generated positive space charge build-up (oxide charge) in thermally grown silicon oxide

  6. The fifth generation computer project state of the art report 111

    CERN Document Server

    Scarrott

    1983-01-01

    The Fifth Generation Computer Project is a two-part book consisting of the invited papers and the analysis. The invited papers examine various aspects of The Fifth Generation Computer Project. The analysis part assesses the major advances of the Fifth Generation Computer Project and provides a balanced analysis of the state of the art in The Fifth Generation. This part provides a balanced and comprehensive view of the development in Fifth Generation Computer technology. The Bibliography compiles the most important published material on the subject of The Fifth Generation.

  7. An Embeddable Virtual Machine for State Space Generation

    NARCIS (Netherlands)

    Weber, M.; Bosnacki, D.; Edelkamp, S.

    2007-01-01

    The semantics of modelling languages are not always specified in a precise and formal way, and their rather complex underlying models make it a non-trivial exercise to reuse them in newly developed tools. We report on experiments with a virtual machine-based approach for state space generation. The

  8. Steady-state heat transfer in an inverted U-tube steam generator

    International Nuclear Information System (INIS)

    Boucher, T.J.

    1987-01-01

    Experimental results are presented involving U-tube steam generator tube bundle local heat transfer and fluid conditions during stead-state, full-power operations performed at high temperatures and pressures with conditions typical of a pressurized water reactor (15.0 MPa primary pressure, 600 K steam generator inlet plenum fluid temperatures, 6.2 MPa secondary pressure). The Semiscale (MOD-2C facility represents the state-of-the-art in measurement of tube local heat transfer data and average tube bundle secondary fluid density at several elevations, which allows an estimate of the axial heat transfer and void distributions during steady-state and transient operations. The method of heat transfer data reduction is presented and the heat flux, secondary convective heat transfer coefficient, and void fraction distributions are quantified for steady-state, full-power operations

  9. A compact, all solid-state LC high voltage generator.

    Science.gov (United States)

    Fan, Xuliang; Liu, Jinliang

    2013-06-01

    LC generator is widely applied in the field of high voltage generation technology. A compact and all solid-state LC high voltage generator based on saturable pulse transformer is proposed in this paper. First, working principle of the generator is presented. Theoretical analysis and circuit simulation are used to verify the design of the generator. Experimental studies of the proposed LC generator with two-stage main energy storage capacitors are carried out. And the results show that the proposed LC generator operates as expected. When the isolation inductance is 27 μH, the output voltage is 1.9 times larger than the charging voltage on single capacitor. The multiplication of voltages is achieved. On the condition that the primary energy storage capacitor is charged to 857 V, the output voltage of the generator can reach to 59.5 kV. The step-up ratio is nearly 69. When self breakdown gas gap switch is used as main switch, the rise time of the voltage pulse on load resistor is 8.7 ns. It means that the series-wound inductance in the discharging circuit is very small in this system. This generator can be employed in two different applications.

  10. Efficient charge generation by relaxed charge-transfer states at organic interfaces

    KAUST Repository

    Vandewal, Koen

    2013-11-17

    Interfaces between organic electron-donating (D) and electron-accepting (A) materials have the ability to generate charge carriers on illumination. Efficient organic solar cells require a high yield for this process, combined with a minimum of energy losses. Here, we investigate the role of the lowest energy emissive interfacial charge-transfer state (CT1) in the charge generation process. We measure the quantum yield and the electric field dependence of charge generation on excitation of the charge-transfer (CT) state manifold via weakly allowed, low-energy optical transitions. For a wide range of photovoltaic devices based on polymer:fullerene, small-molecule:C60 and polymer:polymer blends, our study reveals that the internal quantum efficiency (IQE) is essentially independent of whether or not D, A or CT states with an energy higher than that of CT1 are excited. The best materials systems show an IQE higher than 90% without the need for excess electronic or vibrational energy. © 2014 Macmillan Publishers Limited.

  11. Efficient charge generation by relaxed charge-transfer states at organic interfaces

    KAUST Repository

    Vandewal, Koen; Albrecht, Steve N.; Hoke, Eric T.; Graham, Kenneth; Widmer, Johannes; Douglas, Jessica D.; Schubert, Marcel; Mateker, William R.; Bloking, Jason T.; Burkhard, George F.; Sellinger, Alan; Frechet, Jean; Amassian, Aram; Riede, Moritz Kilian; McGehee, Michael D.; Neher, Dieter; Salleo, Alberto

    2013-01-01

    Interfaces between organic electron-donating (D) and electron-accepting (A) materials have the ability to generate charge carriers on illumination. Efficient organic solar cells require a high yield for this process, combined with a minimum of energy losses. Here, we investigate the role of the lowest energy emissive interfacial charge-transfer state (CT1) in the charge generation process. We measure the quantum yield and the electric field dependence of charge generation on excitation of the charge-transfer (CT) state manifold via weakly allowed, low-energy optical transitions. For a wide range of photovoltaic devices based on polymer:fullerene, small-molecule:C60 and polymer:polymer blends, our study reveals that the internal quantum efficiency (IQE) is essentially independent of whether or not D, A or CT states with an energy higher than that of CT1 are excited. The best materials systems show an IQE higher than 90% without the need for excess electronic or vibrational energy. © 2014 Macmillan Publishers Limited.

  12. Text Generation: The State of the Art and the Literature.

    Science.gov (United States)

    Mann, William C.; And Others

    This report comprises two documents which describe the state of the art of computer generation of natural language text. Both were prepared by a panel of individuals who are active in research on text generation. The first document assesses the techniques now available for use in systems design, covering all of the technical methods by which…

  13. Steam generator tube integrity requirements and operating experience in the United States

    International Nuclear Information System (INIS)

    Karwoski, K.J.

    2009-01-01

    Steam generator tube integrity is important to the safe operation of pressurized-water reactors. For ensuring tube integrity, the U.S. Nuclear Regulatory Commission uses a regulatory framework that is largely performance based. This performance-based framework is supplemented with some prescriptive requirements. The framework recognizes that there are three combinations of tube materials and heat treatments currently used in the United States and that the operating experience depends, in part, on the type of material used. This paper summarizes the regulatory framework for ensuring steam generator tube integrity, it highlights the current status of steam generators, and it highlights some of the steam generator issues and challenges that exist in the United States. (author)

  14. Four Generations of Transition State Analogues for Human Purine Nucleoside Phosphorylase

    Energy Technology Data Exchange (ETDEWEB)

    Ho, M.; Shi, W; Rinaldo-Mathis, A; Tyler, P; Evans, G; Almo, S; Schramm, V

    2010-01-01

    Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it a target for leukemia, autoimmune disorders, and gout. Four generations of ribocation transition-state mimics bound to PNP are structurally characterized. Immucillin-H (K*{sub i} = 58 pM, first-generation) contains an iminoribitol cation with four asymmetric carbons. DADMe-Immucillin-H (K*{sub i} = 9 pM, second-generation), uses a methylene-bridged dihydroxypyrrolidine cation with two asymmetric centers. DATMe-Immucillin-H (K*{sub i} = 9 pM, third-generation) contains an open-chain amino alcohol cation with two asymmetric carbons. SerMe-ImmH (K*{sub i} = 5 pM, fourth-generation) uses achiral dihydroxyaminoalcohol seramide as the ribocation mimic. Crystal structures of PNPs establish features of tight binding to be; (1) ion-pair formation between bound phosphate (or its mimic) and inhibitor cation, (2) leaving-group interactions to N1, O6, and N7 of 9-deazahypoxanthine, (3) interaction between phosphate and inhibitor hydroxyl groups, and (4) His257 interacting with the 5{prime}-hydroxyl group. The first generation analogue is an imperfect fit to the catalytic site with a long ion pair distance between the iminoribitol and bound phosphate and weaker interactions to the leaving group. Increasing the ribocation to leaving-group distance in the second- to fourth-generation analogues provides powerful binding interactions and a facile synthetic route to powerful inhibitors. Despite chemical diversity in the four generations of transition-state analogues, the catalytic site geometry is almost the same for all analogues. Multiple solutions in transition-state analogue design are available to convert the energy of catalytic rate enhancement to binding energy in human PNP.

  15. Generation of an arbitrary concatenated Greenberger-Horne-Zeilinger state with single photons

    Science.gov (United States)

    Chen, Shan-Shan; Zhou, Lan; Sheng, Yu-Bo

    2017-02-01

    The concatenated Greenberger-Horne-Zeilinger (C-GHZ) state is a new kind of logic-qubit entangled state, which may have extensive applications in future quantum communication. In this letter, we propose a protocol for constructing an arbitrary C-GHZ state with single photons. We exploit the cross-Kerr nonlinearity for this purpose. This protocol has some advantages over previous protocols. First, it only requires two kinds of cross-Kerr nonlinearities to generate single phase shifts  ±θ. Second, it is not necessary to use sophisticated m-photon Toffoli gates. Third, this protocol is deterministic and can be used to generate an arbitrary C-GHZ state. This protocol may be useful in future quantum information processing based on the C-GHZ state.

  16. Molecular basis of coiled-coil oligomerization-state specificity.

    Science.gov (United States)

    Ciani, Barbara; Bjelic, Saša; Honnappa, Srinivas; Jawhari, Hatim; Jaussi, Rolf; Payapilly, Aishwarya; Jowitt, Thomas; Steinmetz, Michel O; Kammerer, Richard A

    2010-11-16

    Coiled coils are extensively and successfully used nowadays to rationally design multistranded structures for applications, including basic research, biotechnology, nanotechnology, materials science, and medicine. The wide range of applications as well as the important functions these structures play in almost all biological processes highlight the need for a detailed understanding of the factors that control coiled-coil folding and oligomerization. Here, we address the important and unresolved question why the presence of particular oligomerization-state determinants within a coiled coil does frequently not correlate with its topology. We found an unexpected, general link between coiled-coil oligomerization-state specificity and trigger sequences, elements that are indispensable for coiled-coil formation. By using the archetype coiled-coil domain of the yeast transcriptional activator GCN4 as a model system, we show that well-established trimer-specific oligomerization-state determinants switch the peptide's topology from a dimer to a trimer only when inserted into the trigger sequence. We successfully confirmed our results in two other, unrelated coiled-coil dimers, ATF1 and cortexillin-1. We furthermore show that multiple topology determinants can coexist in the same trigger sequence, revealing a delicate balance of the resulting oligomerization state by position-dependent forces. Our experimental results should significantly improve the prediction of the oligomerization state of coiled coils. They therefore should have major implications for the rational design of coiled coils and consequently many applications using these popular oligomerization domains.

  17. Generation of macroscopic singlet states in atomic ensembles

    Science.gov (United States)

    Tóth, Géza; Mitchell, Morgan W.

    2010-05-01

    We study squeezing of the spin uncertainties by quantum non-demolition (QND) measurement in non-polarized spin ensembles. Unlike the case of polarized ensembles, the QND measurements can be performed with negligible back-action, which allows, in principle, perfect spin squeezing as quantified by Tóth et al (2007 Phys. Rev. Lett. 99 250405). The generated spin states approach many-body singlet states and contain a macroscopic number of entangled particles even when individual spin is large. We introduce the Gaussian treatment of unpolarized spin states and use it to estimate the achievable spin squeezing for realistic experimental parameters. Our proposal might have applications for magnetometry with a high spatial resolution or quantum memories storing information in decoherence free subspaces.

  18. Entanglement Generation with Deformed Barut-Girardello Coherent States as Input States in a Unitary Beam Splitter

    International Nuclear Information System (INIS)

    Berrada, K.; Benmoussa, A.; Hassouni, Y.

    2010-07-01

    Using linear entropy as a measure of entanglement, we investigate the entanglement generated via a beam splitter using deformed Barut-Girardello coherent states. We show that the degree of entanglement depends strongly on the q-deformation parameter and amplitude Z of the states. We compute the Mandel Q parameter to examine the quantum statistical properties of these coherent states and make a comparison with the Glauber coherent states. It is shown that these states are useful to describe the states of real and ideal lasers by a proper choice of their characterizing parameters, using an alteration of the Holstein-Primakoff realization. (author)

  19. Sequentially generated states for the study of two dimensional systems

    Energy Technology Data Exchange (ETDEWEB)

    Banuls, Mari-Carmen; Cirac, J. Ignacio [Max-Planck-Institut fuer Quantenoptik, Garching (Germany); Perez-Garcia, David [Depto. Analisis Matematico, Universidad Complutense de Madrid (Spain); Wolf, Michael M. [Niels Bohr Institut, Copenhagen (Denmark); Verstraete, Frank [Fakultaet fuer Physik, Universitaet Wien (Austria)

    2009-07-01

    The family of Matrix Product States represents a powerful tool for the study of physical one-dimensional quantum many-body systems, such as spin chains. Besides, Matrix Product States can be defined as the family of quantum states that can be sequentially generated in a one-dimensional system. We have introduced a new family of states which extends this sequential definition to two dimensions. Like in Matrix Product States, expectation values of few body observables can be efficiently evaluated and, for the case of translationally invariant systems, the correlation functions decay exponentially with the distance. We show that such states are a subclass of Projected Entangled Pair States and investigate their suitability for approximating the ground states of local Hamiltonians.

  20. Vulnerability-specific stress generation: An examination of negative cognitive and interpersonal styles

    OpenAIRE

    Liu, Richard T.; Alloy, Lauren B.; Mastin, Becky M.; Choi, Jimmy Y.; Boland, Elaine M.; Jenkins, Abby L.

    2014-01-01

    Although there is substantial evidence documenting the stress generation effect in depression (i.e., the tendency for depression-prone individuals to experience higher rates of life stress to which they contribute), additional research is required to advance current understanding of the specific types of dependent stress (i.e., events influenced by characteristics and attendant behaviors of the individual) relevant to this effect. The present study tested an extension of the stress generation...

  1. Generation and measurement of nonclassical states by quantum Fock filter

    International Nuclear Information System (INIS)

    D'Ariano, G.M.; Maccone, L.; Paris, M.G.A.; Sacchi, M.F.

    1999-01-01

    We study a novel optical setup which selects a specific Fock component from a generic input state. The device allows to synthesize number states and superpositions of few number states, and to measure the photon distribution and the density matrix of a generic signal. (Authors)

  2. Analysis of the State of Steam Generator Tubes

    International Nuclear Information System (INIS)

    Bergunker, Olga

    2008-01-01

    The problem of safe operation of SG heat exchanging tubes, of both economical and effective control of their state is still important these days. Issues connected with peculiarities of methods of SG tubes inspection, automated analysis of the inspection results, tubes state analysis and development of algorithms of forecasting their state are considered in this report. The need for effective use of extensive data arrays on SG operation has led to the necessity of creating software tools for collection, storage and analysis of these data. The data-analytical system 'NPP Steam Generators' meant for data systematization and visualization as well as various types of analyses of data on eddy current inspection of WWER-440 and WWER-1000 SG tubes is presented in this report. The main possibilities of the data-analytical system (DAS), the code current state and prospects of its development are shown. The main fields of DAS application are considered and some results of its practical use are mentioned, namely, in the field of forecasting SG tubes state. (authors)

  3. Controversies and Generational Differences: Young People’s Identities in Some European States

    Directory of Open Access Journals (Sweden)

    Alistair Ross

    2012-05-01

    Full Text Available This article explores how young people (aged 12–18 in the four Visegrad states of Poland, Slovakia, Hungary and the Czech Republic are constructing their identities, particularly their sense of attachment to their country and to Europe. This generation is of particular significance, in that they are the first generation for many years to have been born and socialised in wholly independent states that are in a relatively peaceful and stable state. Data was collected through 41 focus groups, conducted in 11 different locations in the different states, and were analysed in terms of the degree of enthusiasm expressed for civic institutions and cultural practices related to the country and to Europe. Two particular areas were identified: the sense of generational difference and the ways in which different groups created “other” communities, within and without their country’s borders. These parameters allow us to distinguish the significant communities that these young people are creating in order to make sense of their social and political worlds.

  4. Quantum cryptography using coherent states: Randomized encryption and key generation

    Science.gov (United States)

    Corndorf, Eric

    With the advent of the global optical-telecommunications infrastructure, an increasing number of individuals, companies, and agencies communicate information with one another over public networks or physically-insecure private networks. While the majority of the traffic flowing through these networks requires little or no assurance of secrecy, the same cannot be said for certain communications between banks, between government agencies, within the military, and between corporations. In these arenas, the need to specify some level of secrecy in communications is a high priority. While the current approaches to securing sensitive information (namely the public-key-cryptography infrastructure and deterministic private-key ciphers like AES and 3DES) seem to be cryptographically strong based on empirical evidence, there exist no mathematical proofs of secrecy for any widely deployed cryptosystem. As an example, the ubiquitous public-key cryptosystems infer all of their secrecy from the assumption that factoring of the product of two large primes is necessarily time consuming---something which has not, and perhaps cannot, be proven. Since the 1980s, the possibility of using quantum-mechanical features of light as a physical mechanism for satisfying particular cryptographic objectives has been explored. This research has been fueled by the hopes that cryptosystems based on quantum systems may provide provable levels of secrecy which are at least as valid as quantum mechanics itself. Unfortunately, the most widely considered quantum-cryptographic protocols (BB84 and the Ekert protocol) have serious implementation problems. Specifically, they require quantum-mechanical states which are not readily available, and they rely on unproven relations between intrusion-level detection and the information available to an attacker. As a result, the secrecy level provided by these experimental implementations is entirely unspecified. In an effort to provably satisfy the cryptographic

  5. Vapor generation – atomic spectrometric techniques. Expanding frontiers through specific-species preconcentration. A review

    International Nuclear Information System (INIS)

    Gil, Raúl A.; Pacheco, Pablo H.; Cerutti, Soledad; Martinez, Luis D.

    2015-01-01

    This article reviews 120 articles found in SCOPUS and specific Journal cites corresponding to the terms ‘preconcentration’; ‘speciation’; ‘vapor generation techniques’ and ‘atomic spectrometry techniques’ in the last 5 years. - Highlights: • Recent advances in vapor generation and atomic spectrometry were reviewed. • Species-specific preconcentration strategies after and before VG were discussed. • New preconcentration and speciation analysis were evaluated within this framework. - Abstract: We review recent progress in preconcentration strategies associated to vapor generation techniques coupled to atomic spectrometric (VGT-AS) for specific chemical species detection. This discussion focuses on the central role of different preconcentration approaches, both before and after VG process. The former was based on the classical solid phase and liquid–liquid extraction procedures which, aided by automation and miniaturization strategies, have strengthened the role of VGT-AS in several research fields including environmental, clinical, and others. We then examine some of the new vapor trapping strategies (atom-trapping, hydride trapping, cryotrapping) that entail improvements in selectivity through interference elimination, but also they allow reaching ultra-low detection limits for a large number of chemical species generated in conventional VG systems, including complete separation of several species of the same element. This review covers more than 100 bibliographic references from 2009 up to date, found in SCOPUS database and in individual searches in specific journals. We finally conclude by giving some outlook on future directions of this field

  6. Vapor generation – atomic spectrometric techniques. Expanding frontiers through specific-species preconcentration. A review

    Energy Technology Data Exchange (ETDEWEB)

    Gil, Raúl A.; Pacheco, Pablo H.; Cerutti, Soledad [Área de Química Analítica, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis, Ciudad de San Luis 5700 (Argentina); Instituto de Química de San Luis, INQUISAL, Centro Científico-Tecnológico de San Luis (CCT-San Luis), Consejo Nacional de Investigaciones Científicas y Universidad Nacional de San Luis, Ciudad de San Luis 5700 (Argentina); Martinez, Luis D., E-mail: ldm@unsl.edu.ar [Área de Química Analítica, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis, Ciudad de San Luis 5700 (Argentina); Instituto de Química de San Luis, INQUISAL, Centro Científico-Tecnológico de San Luis (CCT-San Luis), Consejo Nacional de Investigaciones Científicas y Universidad Nacional de San Luis, Ciudad de San Luis 5700 (Argentina)

    2015-05-22

    This article reviews 120 articles found in SCOPUS and specific Journal cites corresponding to the terms ‘preconcentration’; ‘speciation’; ‘vapor generation techniques’ and ‘atomic spectrometry techniques’ in the last 5 years. - Highlights: • Recent advances in vapor generation and atomic spectrometry were reviewed. • Species-specific preconcentration strategies after and before VG were discussed. • New preconcentration and speciation analysis were evaluated within this framework. - Abstract: We review recent progress in preconcentration strategies associated to vapor generation techniques coupled to atomic spectrometric (VGT-AS) for specific chemical species detection. This discussion focuses on the central role of different preconcentration approaches, both before and after VG process. The former was based on the classical solid phase and liquid–liquid extraction procedures which, aided by automation and miniaturization strategies, have strengthened the role of VGT-AS in several research fields including environmental, clinical, and others. We then examine some of the new vapor trapping strategies (atom-trapping, hydride trapping, cryotrapping) that entail improvements in selectivity through interference elimination, but also they allow reaching ultra-low detection limits for a large number of chemical species generated in conventional VG systems, including complete separation of several species of the same element. This review covers more than 100 bibliographic references from 2009 up to date, found in SCOPUS database and in individual searches in specific journals. We finally conclude by giving some outlook on future directions of this field.

  7. The secondary water chemistry and its quality specification of PWR steam generators

    International Nuclear Information System (INIS)

    Zhang Guiqin.

    1984-01-01

    Reasonably organizing the secondary water chemistry of a steam generator is of great importance for improving thermal-hydraulic characteristics and avoiding or alleviating probability of its internals failures by corrosion. In this paper emphasis is put on importance and task of the secondary water chemistry, the meaning and the control demand for feedwater and boiler water specification. At the same time, the current situation on the secondary water chemistry of PWR steam generators is reviewed generally. (Author)

  8. Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Xiaodi Qiu

    Full Text Available The development of a technique to induce the transformation of somatic cells to a pluripotent state via the ectopic expression of defined transcription factors was a transformational event in the field of regenerative medicine. The development of this technique also impacted ophthalmology, as patient-specific induced pluripotent stemcells (iPSCs may be useful resources for some ophthalmological diseases. The lens is a key refractive element in the eye that focuses images of the visual world onto the retina. To establish a new model for drug screening to treat lens diseases and investigating lens aging and development, we examined whether human lens epithelial cells (HLECs could be induced into iPSCs and if lens-specific differentiation of these cells could be achieved under defined chemical conditions. We first efficiently reprogrammed HLECs from age-related cataract patients to iPSCs with OCT-4, SOX-2, and KLF-4. The resulting HLEC-derived iPS (HLE-iPS colonies were indistinguishable from human ES cells with respect to morphology, gene expression, pluripotent marker expression and their ability to generate all embryonic germ-cell layers. Next, we performed a 3-step induction procedure: HLE-iPS cells were differentiated into large numbers of lens progenitor-like cells with defined factors (Noggin, BMP and FGF2, and we determined that these cells expressed lens-specific markers (PAX6, SOX2, SIX3, CRYAB, CRYAA, BFSP1, and MIP. In addition, HLE-iPS-derived lens cells exhibited reduced expression of epithelial mesenchymal transition (EMT markers compared with human embryonic stem cells (hESCs and fibroblast-derived iPSCs. Our study describes a highly efficient procedure for generating lens progenitor cells from cataract patient HLEC-derived iPSCs. These patient-derived pluripotent cells provide a valuable model for studying the developmental and molecular biological mechanisms that underlie cell determination in lens development and cataract

  9. Flow-induced vibration and fretting-wear specifications to ensure steam-generator and heat exchanger lifetime performance

    International Nuclear Information System (INIS)

    Janzen, V.P.; Han, Y.; Pettigrew, M.J.

    2008-01-01

    The current interest in refurbishment, life extension and new-build activity has meant a renewed emphasis on technical specifications that will ensure improved reliability and longer life. Preventing vibration and fretting-wear problems in steam generators and heat exchangers requires design specifications that bring together specific guidelines, analysis methods, requirements and appropriate performance criteria. The specifications must be firmly based on experimental data and field inspections. In addition, the specifications must be supported by theoretical analyses and fundamental scaling correlations, to cover conditions and geometries over the wide range applicable to existing components and probable future designs. The specifications are expected to evolve to meet changing industry requirements. This paper outlines the steps required to generate and support design specifications, and relates them to typical steam-generator design features and computer modeling capabilities. It also describes current issues that are driving changes to flow-induced vibration and fretting-wear specifications that can be applied to the design process for component refurbishment, replacement or new designs. These issues include recent experimental or field evidence for new excitation mechanisms, e.g., the possibility of in-plane fluidelastic instability of U-tubes, the demand for longer reactor and component lifetimes, the need for better predictions of dynamic properties and vibration response, e.g., two-phase random-turbulence excitation, and requirements to consider system 'excursions' or abnormal scenarios, e.g., a main steam line break in the case of steam generators. The paper describes steps being taken to resolve these issues. (author)

  10. Preparing for what might happen: An episodic specificity induction impacts the generation of alternative future events.

    Science.gov (United States)

    Jing, Helen G; Madore, Kevin P; Schacter, Daniel L

    2017-12-01

    A critical adaptive feature of future thinking involves the ability to generate alternative versions of possible future events. However, little is known about the nature of the processes that support this ability. Here we examined whether an episodic specificity induction - brief training in recollecting details of a recent experience that selectively impacts tasks that draw on episodic retrieval - (1) boosts alternative event generation and (2) changes one's initial perceptions of negative future events. In Experiment 1, an episodic specificity induction significantly increased the number of alternative positive outcomes that participants generated to a series of standardized negative events, compared with a control induction not focused on episodic specificity. We also observed larger decreases in the perceived plausibility and negativity of the original events in the specificity condition, where participants generated more alternative outcomes, relative to the control condition. In Experiment 2, we replicated and extended these findings using a series of personalized negative events. Our findings support the idea that episodic memory processes are involved in generating alternative outcomes to anticipated future events, and that boosting the number of alternative outcomes is related to subsequent changes in the perceived plausibility and valence of the original events, which may have implications for psychological well-being. Published by Elsevier B.V.

  11. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    K.M. Hettne (Kristina); J. Boorsma (Jeffrey); D.A.M. van Dartel (Dorien A M); J.J. Goeman (Jelle); E.C. de Jong (Esther); A.H. Piersma (Aldert); R.H. Stierum (Rob); J. Kleinjans (Jos); J.A. Kors (Jan)

    2013-01-01

    textabstractBackground: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with

  12. Generation of Werner states and preservation of entanglement in a noisy environment

    Energy Technology Data Exchange (ETDEWEB)

    Jakobczyk, Lech [Institute of Theoretical Physics, University of Wroclaw, Pl. M. Borna 9, 50-204 Wroclaw (Poland)]. E-mail: ljak@ift.uni.wroc.pl; Jamroz, Anna [Institute of Theoretical Physics, University of Wroclaw, Pl. M. Borna 9, 50-204 Wroclaw (Poland)

    2005-12-05

    We study the influence of noisy environment on the evolution of two-atomic system in the presence of collective damping. Generation of Werner states as asymptotic stationary states of evolution is described. We also show that for some initial states the amount of entanglement is preserved during the evolution.

  13. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    Hettne, K.M.; Boorsma, A.; Dartel, D.A. van; Goeman, J.J.; Jong, E. de; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

    2013-01-01

    BACKGROUND: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

  14. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    NARCIS (Netherlands)

    Hettne, K.M.; Boorsma, A.; Dartel, van D.A.M.; Goeman, J.J.; Jong, de E.; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

    2013-01-01

    Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

  15. Domain-specific modeling enabling full code generation

    CERN Document Server

    Kelly, Steven

    2007-01-01

    Domain-Specific Modeling (DSM) is the latest approach tosoftware development, promising to greatly increase the speed andease of software creation. Early adopters of DSM have been enjoyingproductivity increases of 500–1000% in production for over adecade. This book introduces DSM and offers examples from variousfields to illustrate to experienced developers how DSM can improvesoftware development in their teams. Two authorities in the field explain what DSM is, why it works,and how to successfully create and use a DSM solution to improveproductivity and quality. Divided into four parts, the book covers:background and motivation; fundamentals; in-depth examples; andcreating DSM solutions. There is an emphasis throughout the book onpractical guidelines for implementing DSM, including how toidentify the nece sary language constructs, how to generate fullcode from models, and how to provide tool support for a new DSMlanguage. The example cases described in the book are available thebook's Website, www.dsmbook....

  16. Generating Safety-Critical PLC Code From a High-Level Application Software Specification

    Science.gov (United States)

    2008-01-01

    The benefits of automatic-application code generation are widely accepted within the software engineering community. These benefits include raised abstraction level of application programming, shorter product development time, lower maintenance costs, and increased code quality and consistency. Surprisingly, code generation concepts have not yet found wide acceptance and use in the field of programmable logic controller (PLC) software development. Software engineers at Kennedy Space Center recognized the need for PLC code generation while developing the new ground checkout and launch processing system, called the Launch Control System (LCS). Engineers developed a process and a prototype software tool that automatically translates a high-level representation or specification of application software into ladder logic that executes on a PLC. All the computer hardware in the LCS is planned to be commercial off the shelf (COTS), including industrial controllers or PLCs that are connected to the sensors and end items out in the field. Most of the software in LCS is also planned to be COTS, with only small adapter software modules that must be developed in order to interface between the various COTS software products. A domain-specific language (DSL) is a programming language designed to perform tasks and to solve problems in a particular domain, such as ground processing of launch vehicles. The LCS engineers created a DSL for developing test sequences of ground checkout and launch operations of future launch vehicle and spacecraft elements, and they are developing a tabular specification format that uses the DSL keywords and functions familiar to the ground and flight system users. The tabular specification format, or tabular spec, allows most ground and flight system users to document how the application software is intended to function and requires little or no software programming knowledge or experience. A small sample from a prototype tabular spec application is

  17. A generator for unique quantum random numbers based on vacuum states

    DEFF Research Database (Denmark)

    Gabriel, C.; Wittmann, C.; Sych, D.

    2010-01-01

    the purity of a continuous-variable quantum vacuum state to generate unique random numbers. We use the intrinsic randomness in measuring the quadratures of a mode in the lowest energy vacuum state, which cannot be correlated to any other state. The simplicity of our source, combined with its verifiably......Random numbers are a valuable component in diverse applications that range from simulations(1) over gambling to cryptography(2,3). The quest for true randomness in these applications has engendered a large variety of different proposals for producing random numbers based on the foundational...... unpredictability of quantum mechanics(4-11). However, most approaches do not consider that a potential adversary could have knowledge about the generated numbers, so the numbers are not verifiably random and unique(12-15). Here we present a simple experimental setup based on homodyne measurements that uses...

  18. State-of-the-Art: DTM Generation Using Airborne LIDAR Data

    Directory of Open Access Journals (Sweden)

    Ziyue Chen

    2017-01-01

    Full Text Available Digital terrain model (DTM generation is the fundamental application of airborne Lidar data. In past decades, a large body of studies has been conducted to present and experiment a variety of DTM generation methods. Although great progress has been made, DTM generation, especially DTM generation in specific terrain situations, remains challenging. This research introduces the general principles of DTM generation and reviews diverse mainstream DTM generation methods. In accordance with the filtering strategy, these methods are classified into six categories: surface-based adjustment; morphology-based filtering, triangulated irregular network (TIN-based refinement, segmentation and classification, statistical analysis and multi-scale comparison. Typical methods for each category are briefly introduced and the merits and limitations of each category are discussed accordingly. Despite different categories of filtering strategies, these DTM generation methods present similar difficulties when implemented in sharply changing terrain, areas with dense non-ground features and complicated landscapes. This paper suggests that the fusion of multi-sources and integration of different methods can be effective ways for improving the performance of DTM generation.

  19. State-of-the-Art: DTM Generation Using Airborne LIDAR Data

    Science.gov (United States)

    Chen, Ziyue; Gao, Bingbo; Devereux, Bernard

    2017-01-01

    Digital terrain model (DTM) generation is the fundamental application of airborne Lidar data. In past decades, a large body of studies has been conducted to present and experiment a variety of DTM generation methods. Although great progress has been made, DTM generation, especially DTM generation in specific terrain situations, remains challenging. This research introduces the general principles of DTM generation and reviews diverse mainstream DTM generation methods. In accordance with the filtering strategy, these methods are classified into six categories: surface-based adjustment; morphology-based filtering, triangulated irregular network (TIN)-based refinement, segmentation and classification, statistical analysis and multi-scale comparison. Typical methods for each category are briefly introduced and the merits and limitations of each category are discussed accordingly. Despite different categories of filtering strategies, these DTM generation methods present similar difficulties when implemented in sharply changing terrain, areas with dense non-ground features and complicated landscapes. This paper suggests that the fusion of multi-sources and integration of different methods can be effective ways for improving the performance of DTM generation. PMID:28098810

  20. Transparency and other State-specific factors: exploration of Ideas for evolving the system of State-evaluations and safeguards implementation of IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Everton, C.; Leslie, R.; Bayer, S.; East, M. [Craig Everton, Russell Leslie, Stephan Bayer, Michael East, Australia (Australia)

    2011-12-15

    In November 2010 the IAEA Department of Safeguards launched its Long Term Strategic Plan at the IAEA Symposium on International Safeguards: 'Preparing for Future Verification Challenges'. A key element of the Long Term Strategic Plan is the further evolution of the State-level approach for safeguards implementation away from criteria driven safeguards approaches focussed at the facility level, to a safeguards system that is objectives-based and fully information-driven. The State-level approach is a holistic approach to safeguards implementation, applicable to all States, incorporating comprehensive State evaluations and safeguards implementation approaches that make use of all information available to the IAEA. In further evolving the State-level concept State-specific factors and acquisition path analysis will become increasingly important in State evaluations and in the determination of safeguards approaches for each State. It will be important to determine objective modalities for incorporating these factors. Consideration of State-specific factors in determining safeguards approaches is not new - in fact, paragraph 81 of INFCIRC/153 (concluded June 1972) enumerates several such factors that can be considered. This paper will explore some ideas for State-specific factors that could be used in State-evaluations, and how these factors could be used for determining State-by-State safeguards approaches. Ideas for State-specific factors will include effectiveness of State Systems of Accountancy and Control (SSAC), transparency of States in their dealings with the IAEA, and characteristics of a nuclear fuel cycle of a State.

  1. Transparency and other State-specific factors: exploration of Ideas for evolving the system of State-evaluations and safeguards implementation of IAEA

    International Nuclear Information System (INIS)

    Everton, C.; Leslie, R.; Bayer, S.; East, M.

    2011-01-01

    In November 2010 the IAEA Department of Safeguards launched its Long Term Strategic Plan at the IAEA Symposium on International Safeguards: 'Preparing for Future Verification Challenges'. A key element of the Long Term Strategic Plan is the further evolution of the State-level approach for safeguards implementation away from criteria driven safeguards approaches focussed at the facility level, to a safeguards system that is objectives-based and fully information-driven. The State-level approach is a holistic approach to safeguards implementation, applicable to all States, incorporating comprehensive State evaluations and safeguards implementation approaches that make use of all information available to the IAEA. In further evolving the State-level concept State-specific factors and acquisition path analysis will become increasingly important in State evaluations and in the determination of safeguards approaches for each State. It will be important to determine objective modalities for incorporating these factors. Consideration of State-specific factors in determining safeguards approaches is not new - in fact, paragraph 81 of INFCIRC/153 (concluded June 1972) enumerates several such factors that can be considered. This paper will explore some ideas for State-specific factors that could be used in State-evaluations, and how these factors could be used for determining State-by-State safeguards approaches. Ideas for State-specific factors will include effectiveness of State Systems of Accountancy and Control (SSAC), transparency of States in their dealings with the IAEA, and characteristics of a nuclear fuel cycle of a State.

  2. Low-noise, transformer-coupled resonant photodetector for squeezed state generation.

    Science.gov (United States)

    Chen, Chaoyong; Shi, Shaoping; Zheng, Yaohui

    2017-10-01

    In an actual setup of squeezed state generation, the stability of a squeezing factor is mainly limited by the performance of the servo-control system, which is mainly influenced by the shot noise and gain of a photodetector. We present a unique transformer-coupled LC resonant amplifier as a photodetector circuit to reduce the electronic noise and increase the gain of the photodetector. As a result, we obtain a low-noise, high gain photodetector with the gain of more than 1.8×10 5 V/A, and the input current noise of less than 4.7 pA/Hz. By adjusting the parameters of the transformer, the quality factor Q of the resonant circuit is close to 100 in the frequency range of more than 100 MHz, which meets the requirement for weak power detection in the application of squeezed state generation.

  3. Generating Models of Infinite-State Communication Protocols Using Regular Inference with Abstraction

    Science.gov (United States)

    Aarts, Fides; Jonsson, Bengt; Uijen, Johan

    In order to facilitate model-based verification and validation, effort is underway to develop techniques for generating models of communication system components from observations of their external behavior. Most previous such work has employed regular inference techniques which generate modest-size finite-state models. They typically suppress parameters of messages, although these have a significant impact on control flow in many communication protocols. We present a framework, which adapts regular inference to include data parameters in messages and states for generating components with large or infinite message alphabets. A main idea is to adapt the framework of predicate abstraction, successfully used in formal verification. Since we are in a black-box setting, the abstraction must be supplied externally, using information about how the component manages data parameters. We have implemented our techniques by connecting the LearnLib tool for regular inference with the protocol simulator ns-2, and generated a model of the SIP component as implemented in ns-2.

  4. Generation of Exotic Quantum States of a Cold Atomic Ensemble

    DEFF Research Database (Denmark)

    Christensen, Stefan Lund

    Over the last decades quantum effects have become more and more controllable, leading to the implementations of various quantum information protocols. These protocols are all based on utilizing quantum correlation. In this thesis we consider how states of an atomic ensemble with such correlations...... can be created and characterized. First we consider a spin-squeezed state. This state is generated by performing quantum non-demolition measurements of the atomic population difference. We show a spectroscopically relevant noise reduction of -1.7dB, the ensemble is in a many-body entangled state...... — a nanofiber based light-atom interface. Using a dual-frequency probing method we measure and prepare an ensemble with a sub-Poissonian atom number distribution. This is a first step towards the implementation of more exotic quantum states....

  5. Cross-Cutting Studies and State-of-the-Practice Reviews: Archive and Use of ITS-Generated Data

    Energy Technology Data Exchange (ETDEWEB)

    Hu, PS

    2002-07-31

    Intelligent Transportation Systems (ITS) provide and use information about transportation conditions to improve system performance in such areas as safety, mobility, efficiency and environmental impacts. Typically, ITS generates massive amounts of data about the state of travel that are used primarily by transportation authorities to effectively operate and manage their transportation systems, and by private individuals and industry to manage trips. These primary uses provide short-term, real-time information regarding the transportation systems current conditions and driver and passenger choices. A broad spectrum of stakeholders could benefit from ITS-generated data to meet their data needs in planning, operations and maintenance, administration, training, modeling, simulations, and development of control strategies. In the context of ADUS, the term ''ITS-generated data'' refers to those data generated by ITS that are primarily used ''in managing system operations and providing information on system conditions and choices to the public.'' Specifically, ADUS refers to data generated from any one of the nine components that make up the ITS infrastructure: (1) freeway management, (2) incident management, (3) arterial management, (4) electronic fare payment, (5) electronic toll collection, (6) transit management, (7) highway-rail intersections, (8) emergency management, and (9) regional multimodal traveler information. The overall objectives of this project are to provide information and reports that can: (1) Provide awareness and education for associated ITS and non-ITS related partners, users, and customers regarding real and potential improvements in transportation decisions through: the use of archived ITS-generated data, the integration of ITS-generated and non-ITS data and data systems, and the sharing of archived ITS-generated data with other potential users. (2) Be used to develop future Technical and Institutional

  6. Design specifications to ensure flow-induced vibration and fretting-wear performance in CANDU steam generators and heat exchangers

    International Nuclear Information System (INIS)

    Janzen, V.P.; Han, Y.; Pettigrew, M.J.

    2009-01-01

    Preventing flow-induced vibration and fretting-wear problems in steam generators and heat exchangers requires design specifications that bring together specific guidelines, analysis methods, requirements and appropriate performance criteria. This paper outlines the steps required to generate and support such design specifications for CANDU nuclear steam generators and heat exchangers, and relates them to typical steam-generator design features and computer modeling capabilities. It also describes current issues that are driving changes to flow-induced vibration and fretting-wear specifications that can be applied to the design process for component refurbishment, replacement or new designs. These issues include recent experimental or field evidence for new excitation mechanisms, e.g., the possibility of in-plane fluidelastic instability of U-tubes, the demand for longer reactor and component lifetimes, the need for better predictions of dynamic properties and vibration response, e.g., two-phase random-turbulence excitation, and requirements to consider system 'excursions' or abnormal scenarios, e.g., a main steam line break in the case of steam generators. The paper describes steps being taken to resolve these issues. (author)

  7. Generating multi-photon W-like states for perfect quantum teleportation and superdense coding

    Science.gov (United States)

    Li, Ke; Kong, Fan-Zhen; Yang, Ming; Ozaydin, Fatih; Yang, Qing; Cao, Zhuo-Liang

    2016-08-01

    An interesting aspect of multipartite entanglement is that for perfect teleportation and superdense coding, not the maximally entangled W states but a special class of non-maximally entangled W-like states are required. Therefore, efficient preparation of such W-like states is of great importance in quantum communications, which has not been studied as much as the preparation of W states. In this paper, we propose a simple optical scheme for efficient preparation of large-scale polarization-based entangled W-like states by fusing two W-like states or expanding a W-like state with an ancilla photon. Our scheme can also generate large-scale W states by fusing or expanding W or even W-like states. The cost analysis shows that in generating large-scale W states, the fusion mechanism achieves a higher efficiency with non-maximally entangled W-like states than maximally entangled W states. Our scheme can also start fusion or expansion with Bell states, and it is composed of a polarization-dependent beam splitter, two polarizing beam splitters and photon detectors. Requiring no ancilla photon or controlled gate to operate, our scheme can be realized with the current photonics technology and we believe it enable advances in quantum teleportation and superdense coding in multipartite settings.

  8. Ultraheavy Yukawa-bound states of fourth-generation at Large ...

    Indian Academy of Sciences (India)

    2012-10-05

    Oct 5, 2012 ... Abstract. A study of bound states of the fourth-generation quarks in the range of 500–700 GeV is presented, where the binding energies are expected to be mainly of Yukawa origin, with QCD subdominant. Near degeneracy of their masses exhibits a new 'isospin'. The production of a colour- octet, isosinglet ...

  9. Study of the technical specifications for the diesels generator of Juragua NPP

    International Nuclear Information System (INIS)

    Vilaragut Llanes, J.J.

    1996-01-01

    The Technical Specifications of a nuclear power plant specify the limits for plant operation from the safety point of view. These operational safety rules were originally defined on the basis of deterministic analysis and engineering judgement. The Probabilistic safety Assessment, constitutes a tool to analyze of the risk effect in the Technical Specifications Rules, and makes possible a relative comparison of the rules from the risk point of view. This paper studies the technical specifications for the diesels generators of Juragua Nuclear Power Plant and for that was used the probabilistic methodology . It is presented the evaluation of the some parameters as surveillance testing, test interval, repairs time, diesel degradation and AOT

  10. Material specification for ductile cast iron in the United States

    International Nuclear Information System (INIS)

    Sorenson, K.B.

    1987-01-01

    The United States currently does not have formal design criteria for qualifying ductile cast iron (DCI) transportation casks. There is also no dedicated material standard for DCI for this particular application. A draft ASTM material specification has been written and is currently in the ASTM approval process. This paper reviews the brief history of the development of the specification, the technical basis for the material properties, the ASTM approval process and the current status of the draft specification. The expected implications of having an adopted ASTM specification on the licensing process are also discussed. (orig./DG)

  11. Generation of Laguerre-Gaussian Beams Using a Diode Pumped Solid-State Digital Laser

    CSIR Research Space (South Africa)

    Bell, Teboho

    2015-10-01

    Full Text Available The solid state digital laser was used in generation of Laguerre-Gaussian modes, LGpl, of different orders. This work demonstrates that we can generate high-order Laguerre-Gaussian modes with high purity using a digital laser....

  12. Aggregation of Distributed Generation Assets in New York State: Appendix

    Energy Technology Data Exchange (ETDEWEB)

    2004-04-01

    This report appendix describes aspects of a project to demonstrate the technical and economic feasibility of aggregating distributed generating resources in New York State. This project demonstrates a system that allows distributed generation (DG) to participate in competitive markets in much the same way as large central-station power plants. This approach involves aggregating the distributed demand-side resources into a single transaction entity consistent with the requirements of the New York Independent System Operator (NYISO). This single entity then buys or sells capacity and energy (i.e., curtailment) in NYISO markets.

  13. Employing online quantum random number generators for generating truly random quantum states in Mathematica

    Science.gov (United States)

    Miszczak, Jarosław Adam

    2013-01-01

    The presented package for the Mathematica computing system allows the harnessing of quantum random number generators (QRNG) for investigating the statistical properties of quantum states. The described package implements a number of functions for generating random states. The new version of the package adds the ability to use the on-line quantum random number generator service and implements new functions for retrieving lists of random numbers. Thanks to the introduced improvements, the new version provides faster access to high-quality sources of random numbers and can be used in simulations requiring large amount of random data. New version program summaryProgram title: TRQS Catalogue identifier: AEKA_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKA_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 18 134 No. of bytes in distributed program, including test data, etc.: 2 520 49 Distribution format: tar.gz Programming language: Mathematica, C. Computer: Any supporting Mathematica in version 7 or higher. Operating system: Any platform supporting Mathematica; tested with GNU/Linux (32 and 64 bit). RAM: Case-dependent Supplementary material: Fig. 1 mentioned below can be downloaded. Classification: 4.15. External routines: Quantis software library (http://www.idquantique.com/support/quantis-trng.html) Catalogue identifier of previous version: AEKA_v1_0 Journal reference of previous version: Comput. Phys. Comm. 183(2012)118 Does the new version supersede the previous version?: Yes Nature of problem: Generation of random density matrices and utilization of high-quality random numbers for the purpose of computer simulation. Solution method: Use of a physical quantum random number generator and an on-line service providing access to the source of true random

  14. Generation of three-mode nonclassical vibrational states of ions

    International Nuclear Information System (INIS)

    Nguyen Ba An; Truong Minh Duc

    2002-01-01

    We propose using eight lasers with appropriate orientations and conditions to generate stable trio coherent states of an ion in a three-dimensional isotropic trap. Seven lasers whose orientations are important should be detuned to the third lower sideband of the ion vibrational motion. The eighth laser whose direction is not important should be in resonance with the ionic transition

  15. Efficient Sampling of the Structure of Crypto Generators' State Transition Graphs

    Science.gov (United States)

    Keller, Jörg

    Cryptographic generators, e.g. stream cipher generators like the A5/1 used in GSM networks or pseudo-random number generators, are widely used in cryptographic network protocols. Basically, they are finite state machines with deterministic transition functions. Their state transition graphs typically cannot be analyzed analytically, nor can they be explored completely because of their size which typically is at least n = 264. Yet, their structure, i.e. number and sizes of weakly connected components, is of interest because a structure deviating significantly from expected values for random graphs may form a distinguishing attack that indicates a weakness or backdoor. By sampling, one randomly chooses k nodes, derives their distribution onto connected components by graph exploration, and extrapolates these results to the complete graph. In known algorithms, the computational cost to determine the component for one randomly chosen node is up to O(√n), which severely restricts the sample size k. We present an algorithm where the computational cost to find the connected component for one randomly chosen node is O(1), so that a much larger sample size k can be analyzed in a given time. We report on the performance of a prototype implementation, and about preliminary analysis for several generators.

  16. Equations of state for self-excited MHD generator studies

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, F.J.; Ross, M.; Haggin, G.L.; Wong, L.K.

    1980-02-26

    We have constructed a state-of-the-art equation of state (EOS) for argon covering the temperature density range attainable by currently proposed self-excited MHD generators. The EOS for conditions in the flow channel was obtained primarily by a non-ideal plasma code (ACTEX) that is based on a many body activity expansion. For conditions in the driver chamber the EOS was primarily obtained from a fluid code (HDFP) that calculates the fluid properties from perturbation theory based on the insulator interatomic pair potential but including electronic excitations. The results are in agreement with several sets of experimental data in the 0.6 - 91 GPa pressure range.

  17. Conditional generation of the Greenberger-Horne-Zeilinger state of four distant atoms via cavity decay

    International Nuclear Information System (INIS)

    Zou, XuBo; Pahlke, K.; Mathis, W.

    2003-01-01

    We propose a scheme to generate a four-particle Greenberger-Horne-Zeilinger (GHZ) state of distant atoms that are trapped separately in leaky cavities. This scheme uses cavity decay to inject photons into a setup of optical devices that consist of a symmetric series of beam splitters and photon detectors. Photon detection on the output modes of the beam splitters projects the atom-cavity-system state onto the GHZ state. It is briefly pointed out that this scheme can be extended to generate GHZ states of 4m atoms

  18. Generation of optical coherent state superpositions for quantum information processing

    DEFF Research Database (Denmark)

    Tipsmark, Anders

    2012-01-01

    I dette projektarbejde med titlen “Generation of optical coherent state superpositions for quantum information processing” har målet været at generere optiske kat-tilstande. Dette er en kvantemekanisk superpositions tilstand af to koherente tilstande med stor amplitude. Sådan en tilstand er...

  19. 77 FR 10475 - Tri-State Generation and Transmission Association, Inc., Notice of Intent To Hold Public Scoping...

    Science.gov (United States)

    2012-02-22

    ... DEPARTMENT OF AGRICULTURE Rural Utilities Service Tri-State Generation and Transmission... proposed project in Colorado by Tri-State Generation and Transmission Association, Inc. (Tri-State). The... Association and Y-W Electric Association. In addition, the following repositories will have the AES and MCS...

  20. Incorporation of wind generation to the Mexican power grid: Steady state analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tovar, J.H.; Guardado, J.L.; Cisneros, F. [Inst. Tecnologico de Morelia (Mexico); Cadenas, R.; Lopez, S. [Comision Federal de Electricidad, Morelia (Mexico)

    1997-09-01

    This paper describes a steady state analysis related with the incorporation of large amounts of eolic generation into the Mexican power system. An equivalent node is used to represent individual eolic generators in the wind farm. Possible overloads, losses, voltage and reactive profiles and estimated severe contingencies are analyzed. Finally, the conclusions of this study are presented.

  1. Generation of multiparticle three-dimensional entanglement state via adiabatic passage

    International Nuclear Information System (INIS)

    Wu Xi; Chen Zhi-Hua; Ye Ming-Yong; Chen Yue-Hua; Lin Xiu-Min

    2013-01-01

    A scheme is proposed for generating a multiparticle three-dimensional entangled state by appropriately adiabatic evolutions, where atoms are respectively trapped in separated cavities so that individual addressing is needless. In the ideal case, losses due to the spontaneous transition of an atom and the excitation of photons are efficiently suppressed since atoms are all in ground states and the fields remain in a vacuum state. Compared with the previous proposals, the present scheme reduces its required operation time via simultaneously controlling four classical fields. This advantage would become even more obvious as the number of atoms increases. The experimental feasibility is also discussed. The successful preparation of a high-dimensional multiparticle entangled state among distant atoms provides better prospects for quantum communication and distributed quantum computation. (general)

  2. Generation-specific incentives and disincentives for nurse faculty to remain employed.

    Science.gov (United States)

    Tourangeau, Ann E; Wong, Matthew; Saari, Margaret; Patterson, Erin

    2015-05-01

    The aims of this paper are to: (1) describe work characteristics that nurse faculty report encourage them to remain in or leave their academic positions; and (2) determine if there are generational differences in work characteristics selected. Nurse faculty play key roles in preparing new nurses and graduate nurses. However, educational institutions are challenged to maintain full employment in faculty positions. A cross-sectional, descriptive survey design was employed. Ontario nurse faculty were asked to select, from a list, work characteristics that entice them to remain in or leave their faculty positions. Respondent data (n = 650) were collected using mailed surveys over four months in 2011. While preferred work characteristics differed across generations, the most frequently selected incentives enticing nurse faculty to stay were having: a supportive director/dean, reasonable workloads, supportive colleagues, adequate resources, manageable class sizes and work/life balance. The most frequently selected disincentives included: unmanageable workloads, unsupportive organizations, poor work environments, exposure to bullying, belittling and other types of incivility in the workplace and having an unsupportive director/dean. This research yields new and important knowledge about work characteristics that nurse faculty report shape their decisions to remain in or leave their current employment. Certain work characteristics were rated as important among all generations. Where similarities exist, broad strategies addressing work characteristics may effectively promote nurse faculty retention. However, where generational differences exist, retention-promoting strategies should target generation-specific preferences. © 2014 John Wiley & Sons Ltd.

  3. Financing the next generation of new reactors in the united states. Panel Discussion

    International Nuclear Information System (INIS)

    Turner, Kyle; Simard, Ron; Tran, K.C.; Kelly, Patrick; Green, Barrett E.; Quinn, Edward L.; Stamos, John

    2001-01-01

    Full text of publication follows: With the California energy shortage and new growth forecasts in the United States, significant new base-load generation will be needed in the near future to meet electricity demands. New figures for growth in electricity demand for the United States rose significantly because of Internet and related business expansion. Lack of sufficient natural gas supplies to support new generation in some regions is causing a renewed interest in building new nuclear plants. Speakers will address the current status of available and near-term design options including both the U.S. Department of Energy Generation III and IV design packages, infrastructure challenges, and financial models that show that nuclear is competitive with alternatives and a prudent and profitable investment. (authors)

  4. Analysis of hydrogen generation according to the specific concrete composition during severe accident

    International Nuclear Information System (INIS)

    Seo, M. R.; Kim, M. K.

    2001-01-01

    The chemical composition of reactor cavity floor concrete affects the kind and amout of gases generated by MCCI and ablation of concrete. And if affects the physical and chemical characteristics of molten pool formed in the cavity. So, the specific concrete compostion is inputted in the MAAP Code used in the Level 2 PSA. and since Ulchin Unit 3 and 4 PSA, the analysis of concrete composition has been performed by the concrete mold prepared for this usage at the installation of cavity floor concrete. But, the composition of domestic concrete for construction of NPP is nearly the same as that of the standard basaltic concrete, and the effect of minor variation in composition is expected to be negligible. This report analyze the effect of the concrete composition to the generation of hydrogen due to MCCI, and discuss the necessity of analysis about the specific concrete composition for Level 2 PSA

  5. Protocol for generating multiphoton entangled states from quantum dots in the presence of nuclear spin fluctuations

    DEFF Research Database (Denmark)

    Denning, Emil Vosmar; Iles-Smith, Jake; McCutcheon, Dara P. S.

    2017-01-01

    Multiphoton entangled states are a crucial resource for many applications inquantum information science. Semiconductor quantum dots offer a promising route to generate such states by mediating photon-photon correlations via a confinedelectron spin, but dephasing caused by the host nuclear spin...... environment typically limits coherence (and hence entanglement) between photons to the spin T2* time of a few nanoseconds. We propose a protocol for the deterministic generation of multiphoton entangled states that is inherently robust against the dominating slow nuclear spin environment fluctuations, meaning...... that coherence and entanglement is instead limited only by the much longer spin T2 time of microseconds. Unlike previous protocols, the present schemeallows for the generation of very low error probability polarisation encoded three-photon GHZ states and larger entangled states, without the need for spin echo...

  6. Invariants-based shortcuts for fast generating Greenberger–Horne–Zeilinger state among three superconducting qubits

    International Nuclear Information System (INIS)

    Xu Jing; Yu Lin; Wu Jin-Lei; Ji Xin

    2017-01-01

    As one of the most promising candidates for implementing quantum computers, superconducting qubits (SQs) are adopted for fast generating the Greenberger–Horne–Zeilinger (GHZ) state by using invariants-based shortcuts. Three SQs are separated and connected by two coplanar waveguide resonators (CPWRs) capacitively. The complicated system is skillfully simplified to a three-state system, and a GHZ state among three SQs is fast generated with a very high fidelity and simple driving pulses. Numerical simulations indicate the scheme is insensitive to parameter deviations. Besides, the robustness of the scheme against decoherence is discussed in detail. (paper)

  7. Generation of Light Scattering States in Cholesteric Liquid Crystals by Optically Controlled Boundary Conditions

    Directory of Open Access Journals (Sweden)

    Timothy J. Bunning

    2013-03-01

    Full Text Available Circularly polarized light was previously employed to stimulate the reversible and reconfigurable writing of scattering states in cholesteric liquid crystal (CLC cells constructed with a photosensitive layer. Such dynamic photodriven responses have utility in remotely triggering changes in optical constructs responsive to optical stimulus and applications where complex spatial patterning is required. Writing of scattering regions required the handedness of incoming radiation to match the handedness of the CLC and the reflection bandwidth of the CLC to envelop the wavelength of the incoming radiation. In this paper, the mechanism of transforming the CLC into a light scattering state via the influence of light on the photosensitive alignment layer is detailed. Specifically, the effects of: (i the polarization state of light on the photosensitive alignment layer; (ii the exposure time; and (iii the incidence angle of radiation on domain formation are reported. The photogenerated light-scattering domains are shown to be similar in appearance between crossed polarizers to a defect structure that occurs at a CLC/air interface (i.e., a free CLC surface. This observation provides strong indication that exposure of the photosensitive alignment layer to the circularly polarized light of appropriate wavelength and handedness generates an out-of-plane orientation leading to a periodic distortion of the original planar structure.

  8. Autocoding State Machine in Erlang

    DEFF Research Database (Denmark)

    Guo, Yu; Hoffman, Torben; Gunder, Nicholas

    2008-01-01

    This paper presents an autocoding tool suit, which supports development of state machine in a model-driven fashion, where models are central to all phases of the development process. The tool suit, which is built on the Eclipse platform, provides facilities for the graphical specification...... of a state machine model. Once the state machine is specified, it is used as input to a code generation engine that generates source code in Erlang....

  9. From UML Specification into FPGA Implementation

    Directory of Open Access Journals (Sweden)

    Grzegorz Bazydlo

    2014-01-01

    Full Text Available In the paper a method of using the Unified Modeling Language for specification of digital systems, especially logic controllers, is presented. The proposed method is based mainly on the UML state machine diagrams and uses Hierarchical Concurrent Finite State Machines (HCFSMs as a temporary model. The paper shows a way to transform the UML diagrams, expressed in XML language, to the form that is acceptable by reconfigurable FPGAs (Field Programmable Gate Arrays. The UML specification is used to generate an effective program in Hardware Description Languages (HDLs, especially Verilog.

  10. Affinity isolation of antigen-specific circulating B cells for generation of phage display-derived human monoclonal antibodies

    DEFF Research Database (Denmark)

    Ditzel, Henrik

    2009-01-01

    A method is described for affinity isolation of antigen-specific circulating B cells of interest for subsequent generation of immune antibody phage display libraries. This approach should overcome the problem of low yields of monoclonal antibodies of interest in the libraries generated from...... peripheral blood lymphocytes caused by the low abundance of antigen-specific B cells in the circulation. The preselection of B cells is based on the specificity of the surface Ig receptor and is accomplished using the antigen of interest conjugated to magnetic beads. This method should significantly increase...... the frequency of antibody phage particles of interest in the library and allow for efficient isolation monoclonal antibodies with the predefined specificity....

  11. Scheme for generating the singlet state of three atoms trapped in distant cavities coupled by optical fibers

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Dong-Yang [Department of Physics, College of Science, Yanbian University, Yanji, Jilin 133002 (China); Wen, Jing-Ji [College of Foundation Science, Harbin University of Commerce, Harbin, Heilongjiang 150028 (China); Bai, Cheng-Hua; Hu, Shi; Cui, Wen-Xue [Department of Physics, College of Science, Yanbian University, Yanji, Jilin 133002 (China); Wang, Hong-Fu, E-mail: hfwang@ybu.edu.cn [Department of Physics, College of Science, Yanbian University, Yanji, Jilin 133002 (China); Zhu, Ai-Dong [Department of Physics, College of Science, Yanbian University, Yanji, Jilin 133002 (China); Zhang, Shou, E-mail: szhang@ybu.edu.cn [Department of Physics, College of Science, Yanbian University, Yanji, Jilin 133002 (China)

    2015-09-15

    An effective scheme is proposed to generate the singlet state with three four-level atoms trapped in three distant cavities connected with each other by three optical fibers, respectively. After a series of appropriate atom–cavity interactions, which can be arbitrarily controlled via the selective pairing of Raman transitions and corresponding optical switches, a three-atom singlet state can be successfully generated. The influence of atomic spontaneous decay, photon leakage of cavities and optical fibers on the fidelity of the state is numerically simulated showing that the three-atom singlet state can be generated with high fidelity by choosing the experimental parameters appropriately.

  12. Generators for Miranda

    Energy Technology Data Exchange (ETDEWEB)

    Angiolini, G.; Borgna, H.; Garcia, A.; Fernandez, M.; Piriz, H.; Verdu, C. [IMPSA Hydrogenerators (Argentina)

    2000-10-01

    The three generators at the Miranda hydroelectric power plant on the Araguari river northwest of Belo Horizonte in the state of Minas Gerais began operation in 1998. All the electromechanical equipment for the project was supplied by IMPSA. The generators, which are driven by Francis turbines, are vertical shaft, three-phase, salient-pole synchronous machines with an output of 137 MVA. The generators successfully completed a series of studies and trials before commercial operation began and Companhia Energetica de Minas Gerais (CEMIG) is considering increasing the operation power to 150 MVA. The specification and design of the electrical aspects, stator winding, rotor, bearings, shaft line, generator cooling system, excitation system and monitoring systems are described. Electromagnetic requirements and acceptance testing results are given in two summary tables.

  13. One-step generation of continuous-variable quadripartite cluster states in a circuit QED system

    Science.gov (United States)

    Yang, Zhi-peng; Li, Zhen; Ma, Sheng-li; Li, Fu-li

    2017-07-01

    We propose a dissipative scheme for one-step generation of continuous-variable quadripartite cluster states in a circuit QED setup consisting of four superconducting coplanar waveguide resonators and a gap-tunable superconducting flux qubit. With external driving fields to adjust the desired qubit-resonator and resonator-resonator interactions, we show that continuous-variable quadripartite cluster states of the four resonators can be generated with the assistance of energy relaxation of the qubit. By comparison with the previous proposals, the distinct advantage of our scheme is that only one step of quantum operation is needed to realize the quantum state engineering. This makes our scheme simpler and more feasible in experiment. Our result may have useful application for implementing quantum computation in solid-state circuit QED systems.

  14. The State of Teacher-Coaches' Sport-Specific Training, Participation ...

    African Journals Online (AJOL)

    The aim of this study was to determine the current state of teacher coaches' sport specific training, playing- and coaching experience regarding sport coaching. Fifty five (55) schools from the Kenneth Kaunda district in the Northwest province of South Africa were selected. Vosloo and Trudel and Camiré's questionnaires ...

  15. A spin-adapted size-extensive state-specific multi-reference perturbation theory. I. Formal developments

    Science.gov (United States)

    Mao, Shuneng; Cheng, Lan; Liu, Wenjian; Mukherjee, Debashis

    2012-01-01

    We present in this paper a comprehensive formulation of a spin-adapted size-extensive state-specific multi-reference second-order perturbation theory (SA-SSMRPT2) as a tool for applications to molecular states of arbitrary complexity and generality. The perturbative theory emerges in the development as a result of a physically appealing quasi-linearization of a rigorously size-extensive state-specific multi-reference coupled cluster (SSMRCC) formalism [U. S. Mahapatra, B. Datta, and D. Mukherjee, J. Chem. Phys. 110, 6171 (1999), 10.1063/1.478523]. The formulation is intruder-free as long as the state-energy is energetically well-separated from the virtual functions. SA-SSMRPT2 works with a complete active space (CAS), and treats each of the model space functions on the same footing. This thus has the twin advantages of being capable of handling varying degrees of quasi-degeneracy and of ensuring size-extensivity. This strategy is attractive in terms of the applicability to bigger systems. A very desirable property of the parent SSMRCC theory is the explicit maintenance of size-extensivity under a variety of approximations of the working equations. We show how to generate both the Rayleigh-Schrödinger (RS) and the Brillouin-Wigner (BW) versions of SA-SSMRPT2. Unlike the traditional naive formulations, both the RS and the BW variants are manifestly size-extensive and both share the avoidance of intruders in the same manner as the parent SSMRCC. We discuss the various features of the RS as well as the BW version using several partitioning strategies of the hamiltonian. Unlike the other CAS based MRPTs, the SA-SSMRPT2 is intrinsically flexible in the sense that it is constructed in a manner that it can relax the coefficients of the reference function, or keep the coefficients frozen if we so desire. We delineate the issues pertaining to the spin-adaptation of the working equations of the SA-SSMRPT2, starting from SSMRCC, which would allow us to incorporate essentially

  16. Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy

    Directory of Open Access Journals (Sweden)

    Xiaojie Wang

    2012-01-01

    Full Text Available Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.

  17. New generation non-stationary portable neutron generators for biophysical applications of Neutron Activation Analysis.

    Science.gov (United States)

    Marchese, N; Cannuli, A; Caccamo, M T; Pace, C

    2017-01-01

    Neutron sources are increasingly employed in a wide range of research fields. For some specific purposes an alternative to existing large-scale neutron scattering facilities, can be offered by the new generation of portable neutron devices. This review reports an overview for such recently available neutron generators mainly addressed to biophysics applications with specific reference to portable non-stationary neutron generators applied in Neutron Activation Analysis (NAA). The review reports a description of a typical portable neutron generator set-up addressed to biophysics applications. New generation portable neutron devices, for some specific applications, can constitute an alternative to existing large-scale neutron scattering facilities. Deuterium-Deuterium pulsed neutron sources able to generate 2.5MeV neutrons, with a neutron yield of 1.0×10 6 n/s, a pulse rate of 250Hz to 20kHz and a duty factor varying from 5% to 100%, when combined with solid-state photon detectors, show that this kind of compact devices allow rapid and user-friendly elemental analysis. "This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo". Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Creating Best Practices for the Submission of Actionable Food and Feed Testing Data Generated in State and Local Laboratories.

    Science.gov (United States)

    Wangsness, Kathryn; Salfinger, Yvonne; Randolph, Robyn; Shea, Shari; Larson, Kirsten

    2017-07-01

    Laboratory accreditation provides a level of standardization in laboratories and confidence in generated food and feed testing results. For some laboratories, ISO/IEC 17025:2005 accreditation may not be fiscally viable, or a requested test method may be out of the scope of the laboratory's accreditation. To assist laboratories for whom accreditation is not feasible, the Association of Public Health Laboratories Data Acceptance Work Group developed a white paper entitled "Best Practices for Submission of Actionable Food and Feed Testing Data Generated in State and Local Laboratories." The basic elements of a quality management system, along with other best practices that state and local food and feed testing laboratories should follow, are included in the white paper. It also covers program-specific requirements that may need to be addressed. Communication with programs and end data users is regarded as essential for establishing the reliability and accuracy of laboratory data. Following these suggested best practices can facilitate the acceptance of laboratory data, which can result in swift regulatory action and the quick removal of contaminated product from the food supply, improving public health nationally.

  19. Radiological Effluent Technical Specifications (RETS) implementation: Zion Generating Station Units 1 and 2

    International Nuclear Information System (INIS)

    Serrano, W.; Akers, D.W.; Duce, S.W.; Mandler, J.W.; Simpson, F.B.; Young, T.E.

    1985-06-01

    A review of the Radiological Effluent Technical Specifications (RETS) of the Zion Generating Station Units 1 and 2 was performed. The principal review guidelines used were NUREG-0133, ''Preparation of Radiological Effluent Technical Specifications for Nuclear Power Plants,'' and Draft 7 of NUREG-0472, Revision 3, ''Radiological Effluent Technical Specifications for Pressurized Water Reactors.'' Draft submittals were discussed with the Licensee by both EG and G and the NRC staff until all items requiring changes to the Technical Specifications were resolved. The Licensee then submitted final proposed RETS to the NRC which were evaluated and found to be in compliance with the NRC review guidelines. The proposed Offsite Dose Calculation Manual was reviewed and generally found to be consistent with the NRC review guidelines. 35 refs., 2 figs., 1 tab

  20. Generation of Bell, NOON and W states via atom interferometry

    Energy Technology Data Exchange (ETDEWEB)

    Islam, Rameez-ul; Saif, Farhan [Department of Electronics, Quaid-i-Azam University, Islamabad (Pakistan); Khosa, Ashfaq H [Centre for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan)

    2008-02-14

    We propose atom interferometric techniques for the generation of Bell, NOON and W states of an electromagnetic field in high-Q cavities. The fundamental constituent of these techniques is off-resonant Bragg diffraction of atomic de Broglie waves. We show good success probabilities for these schemes under the currently available experimental environment of atom interferometry.

  1. Conformation Generation: The State of the Art.

    Science.gov (United States)

    Hawkins, Paul C D

    2017-08-28

    The generation of conformations for small molecules is a problem of continuing interest in cheminformatics and computational drug discovery. This review will present an overview of methods used to sample conformational space, focusing on those methods designed for organic molecules commonly of interest in drug discovery. Different approaches to both the sampling of conformational space and the scoring of conformational stability will be compared and contrasted, with an emphasis on those methods suitable for conformer sampling of large numbers of drug-like molecules. Particular attention will be devoted to the appropriate utilization of information from experimental solid-state structures in validating and evaluating the performance of these tools. The review will conclude with some areas worthy of further investigation.

  2. Nuclear power generation costs in the United States of America

    International Nuclear Information System (INIS)

    Willis, W.F.

    1983-01-01

    Increasing world energy prices and shortages of fuel resources make the utilization of nuclear power extremely important. The United States nuclear power industry represents the largest body of nuclear power experience in the world. Analysis of the recent United States experience of substantial increases in the cost of nuclear power generation provides good insight into the interdependence of technological, financial, and institutional influences and their combined impact on the economic viability of nuclear power generation. The various factors influencing ultimate generation costs, including construction cost, fuel cost, regulatory reviews, and siting considerations are discussed, and their relative impacts are explored, including discussion of design complexity and related regulatory response. A closer look into the recent relatively high escalation of nuclear plant construction costs shows how differing economic conditions can affect the relative cost effectiveness of various methods of power generation. The vulnerability of capital-intensive, long-lead-time projects to changes in economic conditions and uncertainty in future power demands is discussed. Likewise, the pitfalls of new designs and increased sophistication are contrasted to the advantages which result from proven designs, reliable engineering, and shorter lead times. The value of reliable architect-engineers experienced in the design and construction of the plant is discussed. A discussion is presented of additional regulatory requirements stemming from public safety aspects of nuclear power. These include recognition of requirements for the very large effort for quality assurance of materials and workmanship during plant construction and operation. Likewise, a discussion is included of the demanding nature of operations, maintenance, and modification of plants during the operational phase because of the need for highly qualified operations and maintenance personnel and strict quality assurance

  3. Flow-induced vibration in LMFBR steam generators: a state-of-the-art review

    International Nuclear Information System (INIS)

    Shin, Y.S.; Wambsganss, M.W.

    1975-05-01

    This state-of-the-art review identifies and discusses existing methods of flow-induced vibration analysis applicable to steam generators, their limitations, and base-technology needs. Also included are discussions of five different LMFBR steam-generator configurations and important design considerations, failure experiences, possible flow-induced excitation mechanisms, vibration testing, and available methods of vibration analysis. The objectives are to aid LMFBR steam-generator designers in making the best possible evaluation of potential vibration in steam-generator internals, and to provide the basis for development of design guidelines to avoid detrimental flow-induced vibration

  4. Initial-state parton shower kinematics for NLO event generators

    International Nuclear Information System (INIS)

    Odaka, Shigeru; Kurihara, Yoshimasa

    2007-01-01

    We are developing a consistent method to combine tree-level event generators for hadron collision interactions with those including one additional QCD radiation from the initial-state partons, based on the limited leading-log (LLL) subtraction method, aiming at an application to NLO event generators. In this method, a boundary between non-radiative and radiative processes necessarily appears at the factorization scale (μ F ). The radiation effects are simulated using a parton shower (PS) in non-radiative processes. It is therefore crucial in our method to apply a PS which well reproduces the radiation activities evaluated from the matrix-element (ME) calculations for radiative processes. The PS activity depends on the applied kinematics model. In this paper we introduce two models for our simple initial-state leading-log PS: a model similar to the 'old' PYTHIA-PS and a p T -prefixed model motivated by ME calculations. PS simulations employing these models are tested using W-boson production at LHC as an example. Both simulations show a smooth matching to the LLL subtracted W+1 jet simulation in the p T distribution of W bosons, and the summed p T spectra are stable against a variation of μ F , despite that the p T -prefixed PS results in an apparently harder p T spectrum. (orig.)

  5. A model for steady-state large-volume plasma generation

    International Nuclear Information System (INIS)

    Uhm, H.S.; Miller, J.D.; Schneider, R.F.

    1991-01-01

    In this paper, a simple, new scheme to generate a uniform, steady-state, large-volume plasma is presented. The weakly magnetized plasma is created by direct ionization of the background gas by low-energy electrons generated from thermionic filaments. An annular arrangement of the filaments ensures a uniform plasma density in the radial direction as predicted by theory. Experiments have been performed to characterize the plasma generated in such a configuration. In order to explain the experimental observation, we develop a bulk plasma theory based on plasma transport via cross-field diffusion. As assumed in the theoretical model, the experimental measurements indicate a uniform plasma density along the axis. Both the theory and experiment indicate that the plasma density is a function of the square of the external magnetic field. The theory also predicts the plasma density to be proportional to the neutral density to the two-thirds power in agreement with the experimental data. We also observe the experimental data to agree remarkably well with theoretical prediction for a broad range of system parameters

  6. Remembering the past and imagining the future: Selective effects of an episodic specificity induction on detail generation.

    Science.gov (United States)

    Madore, Kevin P; Schacter, Daniel L

    2016-01-01

    According to the constructive episodic simulation hypothesis, remembering past experiences and imagining future experiences both rely heavily on episodic memory. However, recent research indicates that nonepisodic processes such as descriptive ability also influence memory and imagination. We recently found that an episodic specificity induction--brief training in recollecting details of past experiences--enhanced detail generation on memory and imagination tasks but not a picture description task and thereby concluded that the induction can dissociate episodic processes involved in remembering the past and imagining the future from those nonepisodic processes involved in description. To evaluate the generality of our previous findings and to examine the role of generative search in producing those findings, we modified our paradigm so that word cues replaced picture cues, and a word comparison task that requires generation of sentences and word definitions replaced picture description. Young adult participants received either a specificity induction or one of two control inductions before completing the memory, imagination, and word comparison tasks. Replicating and extending our previous work, we found that the specificity induction increased detail generation in memory and imagination without having an effect on word comparison. The induction's selective effect on memory and imagination stemmed from an increase in internal (i.e., on-topic and episodic) details and had no effect on external (e.g., off-topic or semantic) details. The results point to the efficacy of the specificity induction for isolating episodic processes involved in remembering the past and imagining the future even when a nonepisodic task requires generative search.

  7. Generating a Multiphase Equation of State with Swarm Intelligence

    Science.gov (United States)

    Cox, Geoffrey

    2017-06-01

    Hydrocode calculations require knowledge of the variation of pressure of a material with density and temperature, which is given by the equation of state. An accurate model needs to account for discontinuities in energy, density and properties of a material across a phase boundary. When generating a multiphase equation of state the modeller attempts to balance the agreement between the available data for compression, expansion and phase boundary location. However, this can prove difficult because minor adjustments in the equation of state for a single phase can have a large impact on the overall phase diagram. Recently, Cox and Christie described a method for combining statistical-mechanics-based condensed matter physics models with a stochastic analysis technique called particle swarm optimisation. The models produced show good agreement with experiment over a wide range of pressure-temperature space. This talk details the general implementation of this technique, shows example results, and describes the types of analysis that can be performed with this method.

  8. On the Generation of Random Ensembles of Qubits and Qutrits Computing Separability Probabilities for Fixed Rank States

    Directory of Open Access Journals (Sweden)

    Khvedelidze Arsen

    2018-01-01

    Full Text Available The generation of random mixed states is discussed, aiming for the computation of probabilistic characteristics of composite finite dimensional quantum systems. In particular, we consider the generation of random Hilbert-Schmidt and Bures ensembles of qubit and qutrit pairs and compute the corresponding probabilities to find a separable state among the states of a fixed rank.

  9. Oxidatively generated DNA/RNA damage in psychological stress states

    DEFF Research Database (Denmark)

    Jørgensen, Anders

    2013-01-01

    age-related somatic disorders. The overall aim of the PhD project was to investigate the relation between psychopathology, psychological stress, stress hormone secretion and oxidatively generated DNA and RNA damage, as measured by the urinary excretion of markers of whole-body DNA/RNA oxidation (8...... between the 24 h urinary cortisol excretion and the excretion of 8-oxodG/8-oxoGuo, determined in the same samples. Collectively, the studies could not confirm an association between psychological stress and oxidative stress on nucleic acids. Systemic oxidatively generated DNA/RNA damage was increased......Both non-pathological psychological stress states and mental disorders are associated with molecular, cellular and epidemiological signs of accelerated aging. Oxidative stress on nucleic acids is a critical component of cellular and organismal aging, and a suggested pathogenic mechanism in several...

  10. Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards.

    Science.gov (United States)

    Jiang, Guoqian; Evans, Julie; Endle, Cory M; Solbrig, Harold R; Chute, Christopher G

    2016-01-01

    The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development. We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates. A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6). Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.

  11. Audit of Wolf Creek Generating Station, Unit 1 technical specifications. Final technical evaluation report

    International Nuclear Information System (INIS)

    Stromberg, H.M.

    1985-07-01

    This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the Wolf Creek Generating Station Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the assumptions of the Final Safety Analysis Report (FSAR) as amended, the requirements of the Safety Evaluation Report (SER) as supplemented, and the Comments and Responses to the Wolf Creek Technical Specification Draft Inspection Report. A comparative audit of the FSAR as amended, the SER as supplemented, and the Draft Inspection Report was performed with the Wolf Creek T/S. Several discrepancies were identified and subsequently resolved through discussions with the cognizant NRC reviewer, NRC staff reviewers and/or utility representatives. The Wolf Creek Generating Station Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR, SER, and Draft Inspection Report

  12. On the Generation of Intermediate Number Squeezed State of the Quantized Radiation Field

    Science.gov (United States)

    Baseia, B.; de Lima, A. F.; Bagnato, V. S.

    Recently, a new state of the quantized radiation field — the intermediate number squeezed state (INSS) — has been introduced in the literature: it interpolates between the number state |n> and the squeezed state |z, α>=Ŝ(z)|α>, and exhibits interesting nonclassical properties as antibunching, sub-Poissonian statistics and squeezing. Here we introduce a slight modification in the previous definition allowing us a proposal to generate the INSS. Nonclassical properties using a new set of parameters are also studied.

  13. Manual for the ELL (2) - parser generator and tree generator generator

    OpenAIRE

    Heckmann, Reinhold

    1986-01-01

    Regular right part grammars extended by tree generator specifications are interpreted by a combined parser generator and tree generator that produces an ELL(2) parser. This parser is able to translate programs of the specified language into abstract syntax trees according to the tree specifications in the generator input.

  14. Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

    Energy Technology Data Exchange (ETDEWEB)

    Gonta, Denis

    2010-07-07

    Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

  15. Generation of multipartite entangled states for chains of atoms in the framework of cavity-QED

    International Nuclear Information System (INIS)

    Gonta, Denis

    2010-01-01

    Cavity quantum electrodynamics is a research field that studies electromagnetic fields in confined spaces and the radiative properties of atoms in such fields. Experimentally, the simplest example of such system is a single atom interacting with modes of a high-finesse resonator. Theoretically, such system bears an excellent framework for quantum information processing in which atoms and light are interpreted as bits of quantum information and their mutual interaction provides a controllable entanglement mechanism. In this thesis, we present several practical schemes for generation of multipartite entangled states for chains of atoms which pass through one or more high-finesse resonators. In the first step, we propose two schemes for generation of one- and two-dimensional cluster states of arbitrary size. These schemes are based on the resonant interaction of a chain of Rydberg atoms with one or more microwave cavities. In the second step, we propose a scheme for generation of multipartite W states. This scheme is based on the off-resonant interaction of a chain of three-level atoms with an optical cavity and a laser beam. We describe in details all the individual steps which are required to realize the proposed schemes and, moreover, we discuss several techniques to reveal the non-classical correlations associated with generated small-sized entangled states. (orig.)

  16. Automatic Test Pattern Generator for Fuzzing Based on Finite State Machine

    Directory of Open Access Journals (Sweden)

    Ming-Hung Wang

    2017-01-01

    Full Text Available With the rapid development of the Internet, several emerging technologies are adopted to construct fancy, interactive, and user-friendly websites. Among these technologies, HTML5 is a popular one and is widely used in establishing modern sites. However, the security issues in the new web technologies are also raised and are worthy of investigation. For vulnerability investigation, many previous studies used fuzzing and focused on generation-based approaches to produce test cases for fuzzing; however, these methods require a significant amount of knowledge and mental efforts to develop test patterns for generating test cases. To decrease the entry barrier of conducting fuzzing, in this study, we propose a test pattern generation algorithm based on the concept of finite state machines. We apply graph analysis techniques to extract paths from finite state machines and use these paths to construct test patterns automatically. According to the proposal, fuzzing can be completed through inputting a regular expression corresponding to the test target. To evaluate the performance of our proposal, we conduct an experiment in identifying vulnerabilities of the input attributes in HTML5. According to the results, our approach is not only efficient but also effective for identifying weak validators in HTML5.

  17. Final states with 3rd generation quarks @ 13 TeV (resonant or not)

    CERN Document Server

    Everaerts, Pieter Bruno Bart

    2016-01-01

    A wide variety of new physics models gives rise to final states with third-generation quarks. This note presents new results for some of these models using 13 TeV proton-proton collisions at the CERN LHC. Direct production of third-generation supersymmetric superpartners and vector-like quarks are discussed. Also the searches looking for resonances with third-generation quarks are covered. None of the searches discussed here shows an indication of new physics and the new exclusion limits are presented.

  18. Generation of atom-photon entangled states in atomic Bose-Einstein condensate via electromagnetically induced transparency

    International Nuclear Information System (INIS)

    Kuang Leman; Zhou Lan

    2003-01-01

    In this paper, we present a method to generate continuous-variable-type entangled states between photons and atoms in atomic Bose-Einstein condensate (BEC). The proposed method involves an atomic BEC with three internal states, a weak quantized probe laser, and a strong classical coupling laser, which form a three-level Λ-shaped BEC system. We consider a situation where the BEC is in electromagnetically induced transparency with the coupling laser being much stronger than the probe laser. In this case, the upper and intermediate levels are unpopulated, so that their adiabatic elimination enables an effective two-mode model involving only the atomic field at the lowest internal level and the quantized probe laser field. Atom-photon quantum entanglement is created through laser-atom and interatomic interactions, and two-photon detuning. We show how to generate atom-photon entangled coherent states and entangled states between photon (atom) coherent states and atom-(photon-) macroscopic quantum superposition (MQS) states, and between photon-MQS and atom-MQS states

  19. Generating multiphoton Greenberger-Horne-Zeilinger states with weak cross-Kerr nonlinearity

    International Nuclear Information System (INIS)

    Jin, Guang-Sheng; Lin, Yuan; Wu, Biao

    2007-01-01

    We propose a scheme to generate polarization-entangled multiphoton Greenberger-Horne-Zeilinger states with weak cross-Kerr nonlinearity based on controlled bus rotation and subsequent homodyne measurement. Our method is simple in operation and has high success probabilities with near perfect fidelities in an ideal case

  20. Robust random number generation using steady-state emission of gain-switched laser diodes

    International Nuclear Information System (INIS)

    Yuan, Z. L.; Lucamarini, M.; Dynes, J. F.; Fröhlich, B.; Plews, A.; Shields, A. J.

    2014-01-01

    We demonstrate robust, high-speed random number generation using interference of the steady-state emission of guaranteed random phases, obtained through gain-switching a semiconductor laser diode. Steady-state emission tolerates large temporal pulse misalignments and therefore significantly improves the interference quality. Using an 8-bit digitizer followed by a finite-impulse-response unbiasing algorithm, we achieve random number generation rates of 8 and 20 Gb/s, for laser repetition rates of 1 and 2.5 GHz, respectively, with a ±20% tolerance in the interferometer differential delay. We also report a generation rate of 80 Gb/s using partially phase-correlated short pulses. In relation to the field of quantum key distribution, our results confirm the gain-switched laser diode as a suitable light source, capable of providing phase-randomized coherent pulses at a clock rate of up to 2.5 GHz.

  1. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.

    Science.gov (United States)

    Theaker, Sarah M; Rius, Cristina; Greenshields-Watson, Alexander; Lloyd, Angharad; Trimby, Andrew; Fuller, Anna; Miles, John J; Cole, David K; Peakman, Mark; Sewell, Andrew K; Dolton, Garry

    2016-03-01

    Isolation of peptide-specific T-cell clones is highly desirable for determining the role of T-cells in human disease, as well as for the development of therapies and diagnostics. However, generation of monoclonal T-cells with the required specificity is challenging and time-consuming. Here we describe a library-based strategy for the simple parallel detection and isolation of multiple peptide-specific human T-cell clones from CD8(+) or CD4(+) polyclonal T-cell populations. T-cells were first amplified by CD3/CD28 microbeads in a 96U-well library format, prior to screening for desired peptide recognition. T-cells from peptide-reactive wells were then subjected to cytokine-mediated enrichment followed by single-cell cloning, with the entire process from sample to validated clone taking as little as 6 weeks. Overall, T-cell libraries represent an efficient and relatively rapid tool for the generation of peptide-specific T-cell clones, with applications shown here in infectious disease (Epstein-Barr virus, influenza A, and Ebola virus), autoimmunity (type 1 diabetes) and cancer. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  2. The generation of the Greenberger-Horne-Zeilinger state of four distant atoms conditioned on cavity decay

    International Nuclear Information System (INIS)

    Pahlke, Kai; Zou Xubo; Mathis, Wolfgang

    2004-01-01

    We show a way to use an optical device set-up to generate the four-particle Greenberger-Horne-Zeilinger (GHZ) state of atoms, which are trapped separately in leaky cavities. Based on cavity decay, photons are transferred from the atom-cavity systems to a symmetric series of beam splitters and photon detectors. The events of photon detection on the output modes of the beam splitters project the state of the atom-cavity systems onto the GHZ state. It is briefly pointed out how this scheme can be extended to generate GHZ states of 4m atoms

  3. Steady-state heat transfer in an inverted U-tube steam generator

    International Nuclear Information System (INIS)

    Boucher, T.J.

    1986-01-01

    Experimental results are presented involving U-tube steam generator tube bundle local heat transfer and fluid conditions during steady-state, full-power operations performed at high temperatures and pressures with conditions typical of a pressurized water reactor (15.0 MPa primary pressure, 600 K hot-leg fluid temperatures, 6.2 MPa secondary pressure). The MOD-2C facility represents the state-of-the-art in measurement of tube local heat transfer data and average tube bundle secondary fluid density at several elevations, which allows an estimate of the axial heat transfer and void distributions during steady-state and transient operations. The method of heat transfer data reduction is presented and the heat flux, secondary convective heat transfer coefficient, and void fraction distributions are quantified for steady-state, full-power operations

  4. Design specification for the European Spallation Source neutron generating target element

    International Nuclear Information System (INIS)

    Aguilar, A.; Sordo, F.; Mora, T.; Mena, L.; Mancisidor, M.; Aguilar, J.; Bakedano, G.; Herranz, I.; Luna, P.; Magan, M.; Vivanco, R.; Jimenez-Villacorta, F.; Sjogreen, K.; Oden, U.; Perlado, J.M.

    2017-01-01

    The paper addresses some of the most relevant issues concerning the thermal hydraulics and radiation damage of the neutron generation target to be built at the European Spallation Source as recently approved after a critical design review. The target unit consists of a set of Tungsten blocks placed inside a wheel of 2.5 m diameter which rotates at some 0.5 Hz in order to distribute the heat generated from incoming protons which reach the target in the radial direction. The spallation material elements are composed of an array of Tungsten pieces which rest on a rotating steel support (the cassette) and are distributed in a cross-flow configuration. The thermal, mechanical and radiation effects resulting from the impact of a 2 GeV proton pulse are analysed in detail as well as an evaluation of the inventory of spallation products. The current design is found to conform to specifications and found to be robust enough to deal with several accident scenarios.

  5. Design specification for the European Spallation Source neutron generating target element

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar, A. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Sordo, F., E-mail: fernando.sordo@essbilbao.org [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Mora, T. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Mena, L. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Mancisidor, M.; Aguilar, J.; Bakedano, G.; Herranz, I.; Luna, P. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Magan, M.; Vivanco, R. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); Jimenez-Villacorta, F. [Consorcio ESS-BILBAO. Parque Tecnológico Bizkaia. Poligono Ugaldeguren III, Pol. A, 7B, 48170 Zamudio (Spain); Sjogreen, K.; Oden, U. [European Spallation Source ERIC, P.O Box 176, SE-221 00 Lund (Sweden); Perlado, J.M. [Instituto de Fusión Nuclear, José Gutiérrez Abascal, 2, 28006 Madrid (Spain); and others

    2017-06-01

    The paper addresses some of the most relevant issues concerning the thermal hydraulics and radiation damage of the neutron generation target to be built at the European Spallation Source as recently approved after a critical design review. The target unit consists of a set of Tungsten blocks placed inside a wheel of 2.5 m diameter which rotates at some 0.5 Hz in order to distribute the heat generated from incoming protons which reach the target in the radial direction. The spallation material elements are composed of an array of Tungsten pieces which rest on a rotating steel support (the cassette) and are distributed in a cross-flow configuration. The thermal, mechanical and radiation effects resulting from the impact of a 2 GeV proton pulse are analysed in detail as well as an evaluation of the inventory of spallation products. The current design is found to conform to specifications and found to be robust enough to deal with several accident scenarios.

  6. Generation of coherent states of photon-added type via pathway of eigenfunctions

    International Nuclear Information System (INIS)

    Gorska, K; Penson, K A; Duchamp, G H E

    2010-01-01

    We obtain and investigate the regular eigenfunctions of simple differential operators x r d r+1 /dx r+1 , r = 1, 2, ..., with the eigenvalues equal to 1. With the help of these eigenfunctions, we construct a non-unitary analogue of a boson displacement operator which will be acting on the vacuum. In this way, we generate collective quantum states of the Fock space which are normalized and equipped with the resolution of unity with the positive weight functions that we obtain explicitly. These states are thus coherent states in the sense of Klauder. They span the truncated Fock space without first r lowest-lying basis states: |0), |1), ..., |r - 1). These states are squeezed, sub-Poissonian in nature and reminiscent of photon-added states in Agarwal and Tara (1991 Phys. Rev. A 43 492).

  7. Mod-5A Wind Turbine Generator Program Design Report. Volume 4: Drawings and Specifications, Book 1

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

  8. State-Specific Prevalence of Tobacco Product Use Among Adults - United States, 2014-2015.

    Science.gov (United States)

    Odani, Satomi; Armour, Brian S; Graffunder, Corinne M; Willis, Gordon; Hartman, Anne M; Agaku, Israel T

    2018-01-26

    Despite recent declines in cigarette smoking prevalence, the tobacco product landscape has shifted to include emerging tobacco products* (1,2). Previous research has documented adult use of smokeless tobacco and cigarettes by state (3); however, state-specific data on other tobacco products are limited. To assess tobacco product use in the 50 U.S. states and the District of Columbia (DC), CDC and the National Cancer Institute analyzed self-reported use of six tobacco product types: cigarettes, cigars, regular pipes, water pipes, electronic cigarettes (e-cigarettes), and smokeless tobacco products among adults aged ≥18 years using data from the 2014-2015 Tobacco Use Supplement to the Current Population Survey (TUS-CPS). Prevalence of ever-use of any tobacco product ranged from 27.0% (Utah) to 55.4% (Wyoming). Current (every day or some days) use of any tobacco product ranged from 10.2% (California) to 27.7% (Wyoming). Cigarettes were the most common currently used tobacco product in all states and DC. Among current cigarette smokers, the proportion who currently used one or more other tobacco products ranged from 11.5% (Delaware) to 32.3% (Oregon). Differences in tobacco product use across states underscore the importance of implementing proven population-level strategies to reduce tobacco use and expanding these strategies to cover all forms of tobacco marketed in the United States. Such strategies could include comprehensive smoke-free policies, tobacco product price increases, anti-tobacco mass media campaigns, and barrier-free access to clinical smoking cessation resources (1,4).

  9. A study of the public opinion concerning nuclear power generation in the United States

    International Nuclear Information System (INIS)

    Oiso, Shinichi

    2008-01-01

    In this study, I surveyed the outcome of opinion poll about people's attitude toward nuclear power and analysed their awareness of nuclear power generation in the United States. As a result, it was found that percentage of the people who have positive attitude toward nuclear power has been over 60% since 1998. This result corresponds to the fact that people's preference is tending more toward nuclear power generation which is called the nuclear power Renaissance in the United States. Furthermore, analysis of the outcome of the opinion poll in power stations site region was also conducted and it was found that attitude of the people in the site region was more positive than that of average level in the United States. (author)

  10. Study on specificity of leukemia among the second generation of A-bomb survivors

    International Nuclear Information System (INIS)

    Takagi, Nobuhiko

    2012-01-01

    The title specificity was studied and discussed for the leukemia (L) of 5 cases of the second generation who had lived in Osaka (Report 1977) in comparison with published statistic data of the second generation's 15 L cases in a life-span investigation (2003) and of 5,098 L cases in a nationwide report (2003). The A-bomb survivors were exposed in either Hiroshima or Nagasaki. The Osaka cases (4/5 boys) were morbid during 1958-1975, had acute L (myeloid L 3 cases, and unidentified type L 2) and died at ages of 10-19 y. Their parents were exposed to A-bomb directly (2 cases) or due to entrance in the city (3), and 1 father, 3 mothers and 1 couple of parents were exposed. Parent(s) in the life-span investigation were classified in high dose exposure (within 2 km distance from the city) and zero exposure (2.5 km afar from the city and other) groups. Their second generation (13/20 boys) were morbid during 1952-1969 at average age of 9.7 y (high dose group) and 8.3-7.2 y (zero group), and had acute myeloid L (8 cases), acute lymphocytic L (5) and other L. Exposure was to their 12 mothers, 4 fathers and 4 both parents. The nationwide statistics showed L of <18 years old pediatric patients (1986-2000) involving 56.7% boys, of morbid age peak of 3-4 y and of acute lymphocytic L in 68.8%. As above, it seemed that, in the second generation, their mothers were mostly exposed relative to fathers, the morbid sex ratio was higher in boys, morbid age was higher than general, and acute myeloid L was more frequent than general. L of the second generation thus seemed to be somehow specific, particularly in the higher age of morbidity and frequency of acute myeloid L. (T.T.)

  11. Generation of large scale GHZ states with the interactions of photons and quantum-dot spins

    Science.gov (United States)

    Miao, Chun; Fang, Shu-Dong; Dong, Ping; Yang, Ming; Cao, Zhuo-Liang

    2018-03-01

    We present a deterministic scheme for generating large scale GHZ states in a cavity-quantum dot system. A singly charged quantum dot is embedded in a double-sided optical microcavity with partially reflective top and bottom mirrors. The GHZ-type Bell spin state can be created and two n-spin GHZ states can be perfectly fused to a 2n-spin GHZ state with the help of n ancilla single-photon pulses. The implementation of the current scheme only depends on the photon detection and its need not to operate multi-qubit gates and multi-qubit measurements. Discussions about the effect of the cavity loss, side leakage and exciton cavity coupling strength for the fidelity of generated states show that the fidelity can remain high enough by controlling system parameters. So the current scheme is simple and feasible in experiment.

  12. High-Harmonic Generation in Solids with and without Topological Edge States

    DEFF Research Database (Denmark)

    Bauer, Dieter; Hansen, Kenneth Christian Klochmann

    2018-01-01

    High-harmonic generation in the two topological phases of a finite, one-dimensional, periodic structure is investigated using a self-consistent time-dependent density functional theory approach. For harmonic photon energies smaller than the band gap, the harmonic yield is found to differ by up...... to 14 orders of magnitude for the two topological phases. This giant topological effect is explained by the degree of destructive interference in the harmonic emission of all valence-band (and edge-state) electrons, which strongly depends on whether or not topological edge states are present...

  13. Fortran code for generating random probability vectors, unitaries, and quantum states

    Directory of Open Access Journals (Sweden)

    Jonas eMaziero

    2016-03-01

    Full Text Available The usefulness of generating random configurations is recognized in many areas of knowledge. Fortran was born for scientific computing and has been one of the main programming languages in this area since then. And several ongoing projects targeting towards its betterment indicate that it will keep this status in the decades to come. In this article, we describe Fortran codes produced, or organized, for the generation of the following random objects: numbers, probability vectors, unitary matrices, and quantum state vectors and density matrices. Some matrix functions are also included and may be of independent interest.

  14. Pairing vibrational and isospin rotational states in a particle number and isospin projected generator coordinate method

    International Nuclear Information System (INIS)

    Chen, H.T.; Muether, H.; Faessler, A.

    1978-01-01

    Pairing vibrational and isospin rotational states are described in different approximations based on particle number and isospin projected, proton-proton, neutron-neutron and proton-neutron pairing wave functions and on the generator coordinate method (GCM). The investigations are performed in models for which an exact group theoretical solution exists. It turns out that a particle number and isospin projection is essential to yield a good approximation to the ground state or isospin yrast state energies. For strong pairing correlations (pairing force constant equal to the single-particle level distance) isospin cranking (-ωTsub(x)) yields with particle number projected pairing wave function also good agreement with the exact energies. GCM wave functions generated by particle number and isospin projected BCS functions with different amounts of pairing correlations yield for the lowest T=0 and T=2 states energies which are practically indistinguishable from the exact solutions. But even the second and third lowest energies of charge-symmetric states are still very reliable. Thus it is concluded that also in realistic cases isospin rotational and pairing vibrational states may be described in the framework of the GCM method with isospin and particle number projected generating wave functions. (Auth.)

  15. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 5

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. Detail drawings of several assemblies and subassemblies are given. This is the fifth book of volume 4.

  16. National and state-specific health insurance disparities for adults in same-sex relationships.

    Science.gov (United States)

    Gonzales, Gilbert; Blewett, Lynn A

    2014-02-01

    We examined national and state-specific disparities in health insurance coverage, specifically employer-sponsored insurance (ESI) coverage, for adults in same-sex relationships. We used data from the American Community Survey to identify adults (aged 25-64 years) in same-sex relationships (n = 31,947), married opposite-sex relationships (n = 3,060,711), and unmarried opposite-sex relationships (n = 259,147). We estimated multinomial logistic regression models and state-specific relative differences in ESI coverage with predictive margins. Men and women in same-sex relationships were less likely to have ESI than were their married counterparts in opposite-sex relationships. We found ESI disparities among adults in same-sex relationships in every region, but we found the largest ESI gaps for men in the South and for women in the Midwest. ESI disparities were narrower in states that had extended legal same-sex marriage, civil unions, and broad domestic partnerships. Men and women in same-sex relationships experience disparities in health insurance coverage across the country, but residing in a state that recognizes legal same-sex marriage, civil unions, or broad domestic partnerships may improve access to ESI for same-sex spouses and domestic partners.

  17. Generating maximally-path-entangled number states in two spin ensembles coupled to a superconducting flux qubit

    Science.gov (United States)

    Maleki, Yusef; Zheltikov, Aleksei M.

    2018-01-01

    An ensemble of nitrogen-vacancy (NV) centers coupled to a circuit QED device is shown to enable an efficient, high-fidelity generation of high-N00N states. Instead of first creating entanglement and then increasing the number of entangled particles N , our source of high-N00N states first prepares a high-N Fock state in one of the NV ensembles and then entangles it to the rest of the system. With such a strategy, high-N N00N states can be generated in just a few operational steps with an extraordinary fidelity. Once prepared, such a state can be stored over a longer period of time due to the remarkably long coherence time of NV centers.

  18. Mammalian-specific genomic functions: Newly acquired traits generated by genomic imprinting and LTR retrotransposon-derived genes in mammals.

    Science.gov (United States)

    Kaneko-Ishino, Tomoko; Ishino, Fumitoshi

    2015-01-01

    Mammals, including human beings, have evolved a unique viviparous reproductive system and a highly developed central nervous system. How did these unique characteristics emerge in mammalian evolution, and what kinds of changes did occur in the mammalian genomes as evolution proceeded? A key conceptual term in approaching these issues is "mammalian-specific genomic functions", a concept covering both mammalian-specific epigenetics and genetics. Genomic imprinting and LTR retrotransposon-derived genes are reviewed as the representative, mammalian-specific genomic functions that are essential not only for the current mammalian developmental system, but also mammalian evolution itself. First, the essential roles of genomic imprinting in mammalian development, especially related to viviparous reproduction via placental function, as well as the emergence of genomic imprinting in mammalian evolution, are discussed. Second, we introduce the novel concept of "mammalian-specific traits generated by mammalian-specific genes from LTR retrotransposons", based on the finding that LTR retrotransposons served as a critical driving force in the mammalian evolution via generating mammalian-specific genes.

  19. Papers of a Canadian Institute conference on generation adequacy in Ontario : essential updates on the state of generation capacity and the latest efforts to solve the supply crunch

    International Nuclear Information System (INIS)

    2004-01-01

    The issue of power generation and supply in Ontario was addressed at this conference which provided critical information on power supply and the Ontario government's plans for easing the power supply crisis. The state of existing generation assets and the feasibility of potential supply additions were also discussed. Specific issues such as pricing regulations, as well as broader issues such as market conditions and current energy policies were assessed. Planning, investment and issues such as demand-side management were discussed. The role of government, directions for the future, and the phasing out of coal power plants were important focal points. Nuclear power, water power and the search for reliable sources of supply were examined, including the possibility of importing hydro electricity. In addition, key objectives such as clean air strategies and the development of a renewable energy strategy were discussed and various options were identified. The conference featured 24 presentations, of which 8 have been catalogued separately for inclusion in this database. refs., tabs., figs

  20. Shaping a Healthier Generation: Successful State Strategies to Prevent Childhood Obesity

    Science.gov (United States)

    Mulheron, Joyal; Vonasek, Kara

    2009-01-01

    Studies show that childhood obesity has reached epidemic proportions in the United States. Today, more than 23 million American children--or nearly one in every three--are overweight or obese. If childhood obesity is left unaddressed, a generation of individuals could face health, social, and economic challenges that promise to stress government…

  1. RETRANS - A tool to verify the functional equivalence of automatically generated source code with its specification

    International Nuclear Information System (INIS)

    Miedl, H.

    1998-01-01

    Following the competent technical standards (e.g. IEC 880) it is necessary to verify each step in the development process of safety critical software. This holds also for the verification of automatically generated source code. To avoid human errors during this verification step and to limit the cost effort a tool should be used which is developed independently from the development of the code generator. For this purpose ISTec has developed the tool RETRANS which demonstrates the functional equivalence of automatically generated source code with its underlying specification. (author)

  2. Exploiting Stabilizers and Parallelism in State Space Generation with the Symmetry Method

    DEFF Research Database (Denmark)

    Lorentsen, Louise; Kristensen, Lars Michael

    2001-01-01

    The symmetry method is a main reduction paradigm for alleviating the state explosion problem. For large symmetry groups deciding whether two states are symmetric becomes time expensive due to the apparent high time complexity of the orbit problem. The contribution of this paper is to alleviate th...... the negative impact of the orbit problem by the specification of canonical representatives for equivalence classes of states in Coloured Petri Nets, and by giving algorithms exploiting stabilizers and parallelism for computing the condensed state space....

  3. Stable Skin-specific Overexpression of Human CTLA4-Ig in Transgenic Mice through Seven Generations

    Institute of Scientific and Technical Information of China (English)

    Yong WANG; Yong NI; Hong WEI; Feng-Chao WANG; Liang-Peng GE; Xiang GAO

    2006-01-01

    Skin graft rejection is a typical cellular immune response, mainly mediated by T cells. Cytotoxic T lymphocyte associated antigen 4-immunoglobin (CTLA4-Ig) extends graft survival by blocking the T cell co-stimulation pathway and inhibiting T cell activation. To investigate the efficacy of CTLA4-Ig in prolonging skin graft survival, human CTLA4-Ig (hCTLA4-Ig) was engineered to overexpress in mouse skin by transgenesis using the K14 promoter. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot assay indicated that the expression of CTLA4-Ig remained skin-specific and relatively constant compared to the internal control protein, AKT, through seven generations. The presence and concentration of the hCTLA4-Ig protein in transgenic mouse sera was determined by enzyme-linked immunosorbent assay (ELISA), and the results indicated that the serum CTLA4-Ig concentration also remained constant through generations. Survival of transgenic mouse skins grafted onto rat wounds was remarkably prolonged compared to that of wild-type skins from the same mouse strain, and remained comparable among all seven generations. This suggested that the bioactive hCTLA4-Ig protein was stably expressed in transgenical mice through at least seven generations, which was consistent with the stable skin-specific CTLA4-Ig expression.The results demonstrated that the transgenic expression of hCTLA4-Ig in skin driven by the K14 promoter remained constant through generations, and a transgenic line can be established to provide transgenic skin with extended survival reproducibly.

  4. Proton-coupled electron transfer versus hydrogen atom transfer: generation of charge-localized diabatic states.

    Science.gov (United States)

    Sirjoosingh, Andrew; Hammes-Schiffer, Sharon

    2011-03-24

    The distinction between proton-coupled electron transfer (PCET) and hydrogen atom transfer (HAT) mechanisms is important for the characterization of many chemical and biological processes. PCET and HAT mechanisms can be differentiated in terms of electronically nonadiabatic and adiabatic proton transfer, respectively. In this paper, quantitative diagnostics to evaluate the degree of electron-proton nonadiabaticity are presented. Moreover, the connection between the degree of electron-proton nonadiabaticity and the physical characteristics distinguishing PCET from HAT, namely, the extent of electronic charge redistribution, is clarified. In addition, a rigorous diabatization scheme for transforming the adiabatic electronic states into charge-localized diabatic states for PCET reactions is presented. These diabatic states are constructed to ensure that the first-order nonadiabatic couplings with respect to the one-dimensional transferring hydrogen coordinate vanish exactly. Application of these approaches to the phenoxyl-phenol and benzyl-toluene systems characterizes the former as PCET and the latter as HAT. The diabatic states generated for the phenoxyl-phenol system possess physically meaningful, localized electronic charge distributions that are relatively invariant along the hydrogen coordinate. These diabatic electronic states can be combined with the associated proton vibrational states to generate the reactant and product electron-proton vibronic states that form the basis of nonadiabatic PCET theories. Furthermore, these vibronic states and the corresponding vibronic couplings may be used to calculate rate constants and kinetic isotope effects of PCET reactions.

  5. Automatic generation of a subject-specific model for accurate markerless motion capture and biomechanical applications.

    Science.gov (United States)

    Corazza, Stefano; Gambaretto, Emiliano; Mündermann, Lars; Andriacchi, Thomas P

    2010-04-01

    A novel approach for the automatic generation of a subject-specific model consisting of morphological and joint location information is described. The aim is to address the need for efficient and accurate model generation for markerless motion capture (MMC) and biomechanical studies. The algorithm applied and expanded on previous work on human shapes space by embedding location information for ten joint centers in a subject-specific free-form surface. The optimal locations of joint centers in the 3-D mesh were learned through linear regression over a set of nine subjects whose joint centers were known. The model was shown to be sufficiently accurate for both kinematic (joint centers) and morphological (shape of the body) information to allow accurate tracking with MMC systems. The automatic model generation algorithm was applied to 3-D meshes of different quality and resolution such as laser scans and visual hulls. The complete method was tested using nine subjects of different gender, body mass index (BMI), age, and ethnicity. Experimental training error and cross-validation errors were 19 and 25 mm, respectively, on average over the joints of the ten subjects analyzed in the study.

  6. Computer Software Configuration Item-Specific Flight Software Image Transfer Script Generator

    Science.gov (United States)

    Bolen, Kenny; Greenlaw, Ronald

    2010-01-01

    A K-shell UNIX script enables the International Space Station (ISS) Flight Control Team (FCT) operators in NASA s Mission Control Center (MCC) in Houston to transfer an entire or partial computer software configuration item (CSCI) from a flight software compact disk (CD) to the onboard Portable Computer System (PCS). The tool is designed to read the content stored on a flight software CD and generate individual CSCI transfer scripts that are capable of transferring the flight software content in a given subdirectory on the CD to the scratch directory on the PCS. The flight control team can then transfer the flight software from the PCS scratch directory to the Electronically Erasable Programmable Read Only Memory (EEPROM) of an ISS Multiplexer/ Demultiplexer (MDM) via the Indirect File Transfer capability. The individual CSCI scripts and the CSCI Specific Flight Software Image Transfer Script Generator (CFITSG), when executed a second time, will remove all components from their original execution. The tool will identify errors in the transfer process and create logs of the transferred software for the purposes of configuration management.

  7. Randomly Generating Four Mixed Bell-Diagonal States with a Concurrences Sum to Unity

    International Nuclear Information System (INIS)

    Toh, S. P.; Zainuddin Hishamuddin; Foo Kim Eng

    2012-01-01

    A two-qubit system in quantum information theory is the simplest bipartite quantum system and its concurrence for pure and mixed states is well known. As a subset of two-qubit systems, Bell-diagonal states can be depicted by a very simple geometrical representation of a tetrahedron with sides of length 2√2. Based on this geometric representation, we propose a simple approach to randomly generate four mixed Bell decomposable states in which the sum of their concurrence is equal to one. (general)

  8. Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)--application of steady-state PBPK model solutions.

    Science.gov (United States)

    Aylward, Lesa L; Kirman, Chris R; Blount, Ben C; Hays, Sean M

    2010-10-01

    The National Health and Nutrition Examination Survey (NHANES) generates population-representative biomonitoring data for many chemicals including volatile organic compounds (VOCs) in blood. However, no health or risk-based screening values are available to evaluate these data from a health safety perspective or to use in prioritizing among chemicals for possible risk management actions. We gathered existing risk assessment-based chronic exposure reference values such as reference doses (RfDs), reference concentrations (RfCs), tolerable daily intakes (TDIs), cancer slope factors, etc. and key pharmacokinetic model parameters for 47 VOCs. Using steady-state solutions to a generic physiologically-based pharmacokinetic (PBPK) model structure, we estimated chemical-specific steady-state venous blood concentrations across chemicals associated with unit oral and inhalation exposure rates and with chronic exposure at the identified exposure reference values. The geometric means of the slopes relating modeled steady-state blood concentrations to steady-state exposure to a unit oral dose or unit inhalation concentration among 38 compounds with available pharmacokinetic parameters were 12.0 microg/L per mg/kg-d (geometric standard deviation [GSD] of 3.2) and 3.2 microg/L per mg/m(3) (GSD=1.7), respectively. Chemical-specific blood concentration screening values based on non-cancer reference values for both oral and inhalation exposure range from 0.0005 to 100 microg/L; blood concentrations associated with cancer risk-specific doses at the 1E-05 risk level ranged from 5E-06 to 6E-02 microg/L. The distribution of modeled steady-state blood concentrations associated with unit exposure levels across VOCs may provide a basis for estimating blood concentration screening values for VOCs that lack chemical-specific pharmacokinetic data. The screening blood concentrations presented here provide a tool for risk assessment-based evaluation of population biomonitoring data for VOCs and

  9. 1995 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, R.L.

    1996-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This report provides both national and state-specific disposal data on low-level radioactive waste commercially disposed in US. Data in this report are categorized according to disposal site, generator category, waste class, volumes, and radionuclide activity. Included are tables showing the distribution of waste by state for 1995 and a comparison of waste volumes and radioactivity by state for 1991 through 1995; also included is a list of all commercial nuclear power reactors in US as of Dec. 31, 1994. This report distinguishes low-level radioactive waste shipped directly for disposal by generators and waste handled by an intermediary.

  10. Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System

    Directory of Open Access Journals (Sweden)

    Raul Vizcardo

    2018-03-01

    Full Text Available Summary: Induced pluripotent stem cell (iPSC-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical translation. Our data indicate that these iPSC-derived CD8 single-positive T cells are more like CD4+CD8+ double-positive T cells than mature naive T cells because they display phenotypic markers of developmental arrest and an innate-like phenotype after stimulation. We developed a 3D thymic culture system to avoid these aberrant developmental fates, generating a homogeneous subset of CD8αβ+ antigen-specific T cells, designated iPSC-derived thymic emigrants (iTEs. iTEs exhibit phenotypic and functional similarities to naive T cells both in vitro and in vivo, including the capacity for expansion, memory formation, and tumor suppression. These data illustrate the limitations of current methods and provide a tool to develop the next generation of iPSC-based antigen-specific immunotherapies. : A barrier for clinical application of iPSC-derived CD8 T cells using OP9/DLL1 is their abnormal biology. Vizcardo et al. show that a 3D thymic culture system enables the generation of a homogeneous antigen-specific T cell subset, named iTEs, which closely mimics naive T cells and exhibits potent anti-tumor activity. Keywords: thymopoiesis, T cell differentiation, iPSC differentiation, adoptive cell transfer, naïve T cell, recent rhymic emigrants, fetal thymus organ culture, immunotherapy, 3D culture, tumor antigen specific T cell

  11. Reduced brain resting-state network specificity in infants compared with adults.

    Science.gov (United States)

    Wylie, Korey P; Rojas, Donald C; Ross, Randal G; Hunter, Sharon K; Maharajh, Keeran; Cornier, Marc-Andre; Tregellas, Jason R

    2014-01-01

    Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults. Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups. Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults. We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience.

  12. Cooperation, confrontation, and communication: Key elements to a multi state LLRW generators' association

    International Nuclear Information System (INIS)

    Vincenti, J.R.; Slack, S.T.; McIntire, J.W.; Stigers, R.A.; Nagle, J.C.

    1992-01-01

    The Appalachian Compact Users of Radioactive Isotopes (ACURI) is a foul-state trade association of licensees and permit holders of radioactive materials within the Appalachian States Compact, including Delaware, Maryland, Pennsylvania, and West Virginia. ACURI's primary focus is on low-level radioactive waste (LLRW) management and disposal issues. This paper will review 1) development of an association; 2) interaction with state and federal regulators and the Compact's LLRW siting contractor; 3) special work on licensing and other user/generator issues; 4) role of ACURI at the national level; and, 5) impact of ACURI on the siting process and involvement with local and state officials, special interest groups, and the public. (author)

  13. Generating method-specific Reference Ranges - A harmonious outcome?

    Science.gov (United States)

    Lee, Graham R; Griffin, Alison; Halton, Kieran; Fitzgibbon, Maria C

    2017-12-01

    When laboratory Reference Ranges (RR) do not reflect analytical methodology, result interpretation can cause misclassification of patients and inappropriate management. This can be mitigated by determining and implementing method-specific RRs, which was the main objective of this study. Serum was obtained from healthy volunteers (Male + Female, n > 120) attending hospital health-check sessions during June and July 2011. Pseudo-anonymised aliquots were stored (at - 70 °C) prior t° analysis on Abbott ARCHITECT c16000 chemistry and i 2000SR immunoassay analysers. Data were stratified by gender where appropriate. Outliers were excluded statistically (Tukey method) to generate non-parametric RRs (2.5th + 97.5th percentiles). RRs were compared to those quoted by Abbott and UK Pathology Harmony (PH) where possible. For 7 selected tests, RRs were verified using a data mining approach. For chemistry tests (n = 23), Upper or Lower Reference Limits (LRL or URL) were > 20% different from Abbott ranges in 25% of tests (11% from PH ranges) but in 38% for immunoassay tests (n = 13). RRs (mmol/L) for sodium (138-144), potassium (3.8-4.9) and chloride (102-110) were considerably narrower than PH ranges (133-146, 3.5-5.0 and 95-108, respectively). The gender difference for ferritin (M: 29-441, F: 8-193 ng/mL) was more pronounced than reported by Abbott (M: 22-275, F: 5-204 ng/mL). Verification studies showed good agreement for chemistry tests (mean [SD] difference = 0.4% [1.2%]) but less so for immunoassay tests (27% [29%]), particularly for TSH (LRL). Where resource permits, we advocate using method-specific RRs in preference to other sources, particularly where method bias and lack of standardisation limits RR transferability and harmonisation.

  14. Cassie state robustness of plasma generated randomly nano-rough surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Di Mundo, Rosa, E-mail: rosa.dimundo@poliba.it; Bottiglione, Francesco; Carbone, Giuseppe

    2014-10-15

    Graphical abstract: - Highlights: • Superhydrophobic randomly rough surfaces are generated by plasma etching. • Statistical analysis of roughness allows calculation of theWenzel roughness factor, r{sub W.} • A r{sub W} threshold is theoretically determined, above which superhydrophobicity is “robust”. • Dynamic wetting, e.g. with high speed impacting drops, confirms this prediction. - Abstract: Superhydrophobic surfaces are effective in practical applications provided they are “robust superhydrophobic”, i.e. able to retain the Cassie state, i.e. with water suspended onto the surface protrusions, even under severe conditions (high pressure, vibrations, high speed impact, etc.). We show that for randomly rough surfaces, given the Young angle, Cassie states are robust when a threshold value of the Wenzel roughness factor, r{sub W}, is exceeded. In particular, superhydrophobic nano-textured surfaces have been generated by self-masked plasma etching. In view of their random roughness, topography features, acquired by Atomic Force Microscopy, have been statistically analyzed in order to gain information on statistical parameters such as power spectral density, fractal dimension and Wenzel roughness factor (r{sub W}), which has been used to assess Cassie state robustness. Results indicate that randomly rough surfaces produced by plasma at high power or long treatment duration, which are also fractal self-affine, have a r{sub W} higher than the theoretical threshold, thus for them a robust superhydrophobicity is predicted. In agreement with this, under dynamic wetting conditionson these surfaces the most pronounced superhydrophobic character has been appreciated: they show the lowest contact angle hysteresis and result in the sharpest bouncing when hit by drops at high impact velocity.

  15. Geothermal power generation in the United States 1985 through 1989

    International Nuclear Information System (INIS)

    Rannels, J.E.; McLarty, L.

    1990-01-01

    The United States has used geothermal energy for the production of electricity since 1960 and has the largest installed capacity of any country in the world. During the 1980s, expansion at The Geysers and emergence of the hot water segment of the industry fueled explosive growth in generating capacity. In this paper geothermal development in the U.S. during the second half of the decade is reviewed, and development over the next five years is forecast

  16. 1996 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, R.L.

    1997-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This report provides both national and state-specific disposal data on low-level radioactive waste commercially disposed in the US. Data in this report are categorized according to disposal site, generator category, waste class, volumes, and radionuclide activity. Included in this report are tables showing the distribution of waste by state for 1996 and a comparison of waste volumes and radioactivity by state for 1992 through 1996; also included is a list of all commercial nuclear power reactors in the US as of December 31, 1996. This report distinguishes between low-level radioactive waste shipped directly for disposal by generators and waste that was handled by an intermediary, a reporting change introduced in the 1988 state-by-state report.

  17. 1992 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites

    International Nuclear Information System (INIS)

    Fuchs, R.L.; McDonald, S.D.

    1993-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This report provides both national and state-specific disposal data on low-level radioactive waste commercially disposed in the United States. Data in this report are categorized according to disposal site, generator category, waste class, volumes, and radionuclide activity. Included in this report are tables showing the distribution of waste by state for 1992 and a comparison of waste volumes and radioactivity by state for 1988 through 1992; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1992. This report distinguishes between low-level radioactive waste shipped directly for disposal by generators and waste that was handled by an intermediary, a reporting change introduced in the 1988 state-by-state report

  18. 1994 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This report provides both national and state-specific disposal data on low-level radioactive waste commercially disposed in the United States. Data in this report are categorized according to disposal site, generator category, waste class, volumes, and radionuclide activity. Included in this report are tables showing the distribution of waste by state for 1994 and a comparison of waste volumes and radioactivity by state for 1990 through 1994; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1994. This report distinguishes between low-level radioactive waste shipped directly for disposal by generators and waste that was handled by an intermediary, a reporting change introduced in the 1988 state-by-state report.

  19. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Bers, A.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma

  20. Age specific interactions between smoking and radon among United States uranium miners

    International Nuclear Information System (INIS)

    Steenland, K.

    1994-01-01

    United States uranium miners who smoked have death rates from lung cancer that are intermediate between the rates predicted by the additive and multiplicative models (on a ratio scale) across all age groups. Age specific patterns of interaction have not been thoroughly examined, and most analyses have been internal ones in which there was no truly non-exposed group. Here age specific death rates of lung cancer among ever smoking uranium miners have been examined for conformity with the additive and multiplicative models. The multiplicative model fits well for the youngest and oldest categories, but poorly for the middle age ranges. In the middle age range, predicted rates under the multiplicative model were quite high, surpassing the corresponding United States death rates for all causes combined. (Author)

  1. Generation of Recombinant Porcine Parvovirus Virus-Like Particles in Saccharomyces cerevisiae and Development of Virus-Specific Monoclonal Antibodies

    Directory of Open Access Journals (Sweden)

    Paulius Lukas Tamošiūnas

    2014-01-01

    Full Text Available Porcine parvovirus (PPV is a widespread infectious virus that causes serious reproductive diseases of swine and death of piglets. The gene coding for the major capsid protein VP2 of PPV was amplified using viral nucleic acid extract from swine serum and inserted into yeast Saccharomyces cerevisiae expression plasmid. Recombinant PPV VP2 protein was efficiently expressed in yeast and purified using density gradient centrifugation. Electron microscopy analysis of purified PPV VP2 protein revealed the self-assembly of virus-like particles (VLPs. Nine monoclonal antibodies (MAbs against the recombinant PPV VP2 protein were generated. The specificity of the newly generated MAbs was proven by immunofluorescence analysis of PPV-infected cells. Indirect IgG ELISA based on the recombinant VLPs for detection of PPV-specific antibodies in swine sera was developed and evaluated. The sensitivity and specificity of the new assay were found to be 93.4% and 97.4%, respectively. In conclusion, yeast S. cerevisiae represents a promising expression system for generating recombinant PPV VP2 protein VLPs of diagnostic relevance.

  2. The 1988 state-by-state assessment of Low-Level Radioactive Wastes received at commercial disposal sites

    International Nuclear Information System (INIS)

    Fuchs, R.L.; Culbertson-Arendts, K.

    1989-12-01

    This report provides both national and state-specific disposal data on low-level radioactive wastes. Data in this report are divided into generator categories, waste classes, volumes, and activities. Included in this report are tables showing a distribution of wastes by state for 1988 and a comparison of waste volumes by state for 1984 through 1988; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1988. In this year's report, a distinction has been made between low-level radioactive waste shipped directly for disposal by generators and that which was handled by an intermediary. 8 refs., 3 tabs

  3. A 70 kV solid-state high voltage pulse generator based on saturable pulse transformer.

    Science.gov (United States)

    Fan, Xuliang; Liu, Jinliang

    2014-02-01

    High voltage pulse generators are widely applied in many fields. In recent years, solid-state and operating at repetitive mode are the most important developing trends of high voltage pulse generators. A solid-state high voltage pulse generator based on saturable pulse transformer is proposed in this paper. The proposed generator is consisted of three parts. They are charging system, triggering system, and the major loop. Saturable pulse transformer is the key component of the whole generator, which acts as a step-up transformer and main switch during working process of this generator. The circuit and working principles of the proposed pulse generator are introduced first in this paper, and the saturable pulse transformer used in this generator is introduced in detail. Circuit of the major loop is simulated to verify the design of the system. Demonstration experiments are carried out, and the results show that when the primary energy storage capacitor is charged to a high voltage, such as 2.5 kV, a voltage with amplitude of 86 kV can be achieved on the secondary winding. The magnetic core of saturable pulse transformer is saturated deeply and the saturable inductance of the secondary windings is very small. The switch function of the saturable pulse transformer can be realized ideally. Therefore, a 71 kV output voltage pulse is formed on the load. Moreover, the magnetic core of the saturable pulse transformer can be reset automatically.

  4. Screening for SNPs with Allele-Specific Methylation based on Next-Generation Sequencing Data

    OpenAIRE

    Hu, Bo; Ji, Yuan; Xu, Yaomin; Ting, Angela H

    2013-01-01

    Allele-specific methylation (ASM) has long been studied but mainly documented in the context of genomic imprinting and X chromosome inactivation. Taking advantage of the next-generation sequencing technology, we conduct a high-throughput sequencing experiment with four prostate cell lines to survey the whole genome and identify single nucleotide polymorphisms (SNPs) with ASM. A Bayesian approach is proposed to model the counts of short reads for each SNP conditional on its genotypes of multip...

  5. Greenberger-Horne-Zeilinger-type and W-type entangled coherent states: Generation and Bell-type inequality tests without photon counting

    International Nuclear Information System (INIS)

    Jeong, Hyunseok; Nguyen Ba An

    2006-01-01

    We study Greenberger-Horne-Zeilinger-type (GHZ-type) and W-type three-mode entangled coherent states. Both types of entangled coherent states violate Mermin's version of the Bell inequality with threshold photon detection (i.e., without photon counting). Such an experiment can be performed using linear optics elements and threshold detectors with significant Bell violations for GHZ-type entangled coherent states. However, to demonstrate Bell-type inequality violations for W-type entangled coherent states, additional nonlinear interactions are needed. We also propose an optical scheme to generate W-type entangled coherent states in free-traveling optical fields. The required resources for the generation are a single-photon source, a coherent state source, beam splitters, phase shifters, photodetectors, and Kerr nonlinearities. Our scheme does not necessarily require strong Kerr nonlinear interactions; i.e., weak nonlinearities can be used for the generation of the W-type entangled coherent states. Furthermore, it is also robust against inefficiencies of the single-photon source and the photon detectors

  6. Self-Tuning Linear Quadratic Supervisory Regulation of a Diesel Generator using Large-Signal State Estimation

    DEFF Research Database (Denmark)

    Knudsen, Jesper Viese; Bendtsen, Jan Dimon; Andersen, Palle

    2016-01-01

    In this paper, a self-tuning linear quadratic supervisory regulator using a large-signal state estimator for a diesel driven generator set is proposed. The regulator improves operational efficiency, in comparison to current implementations, by (i) automating the initial tuning process and (ii...... throughout the operating range of the diesel generator....

  7. Generation of two-temporal-mode photon states by vector four-wave mixing

    DEFF Research Database (Denmark)

    Mckinstrie, C. J.; Christensen, J. B.; Rottwitt, Karsten

    2017-01-01

    Photon pair states and multiple-photon squeezed states have many applications in quantum information science. In this paper, Green functions are derived for spontaneous four-wave mixing in the low-and high-gain regimes. Nondegenerate four-wave mixing in a strongly-birefringent medium generates...... signal and idler photons that are associated with only one pair of temporal (Schmidt) modes, for a wide range of pump powers and arbitrary pump shapes. The Schmidt coefficients (expected photon numbers) depend sensitively on the pump powers, and the Schmidt functions (shapes of the photon wavepackets...

  8. National and State-Specific Sales and Prices for Electronic Cigarettes-U.S., 2012-2013.

    Science.gov (United States)

    Loomis, Brett R; Rogers, Todd; King, Brian A; Dench, Daniel L; Gammon, Doris G; Fulmer, Erika B; Agaku, Israel T

    2016-01-01

    The growing market for electronic cigarettes (e-cigarettes) has been widely reported in the media, but very little objective data exist in the scientific literature, and no data have been published on state-specific trends in prices or sales. Our objective is to assess state-specific annual sales and average prices for e-cigarettes in the U.S. Commercial retail scanner data were used to assess total dollar sales and average price per unit for disposable e-cigarettes, starter kits, and cartridge refills for selected states and the total U.S. during 2012-2013. Data were analyzed in 2014. Data were available for convenience stores (29 states) and food, drug, and mass merchandisers (44 states). In convenience stores, dollar sales increased markedly during 2012-2013: 320.8% for disposable e-cigarettes, 72.4% for starter kits, and 82% for cartridges. In food, drug, and mass merchandisers, dollar sales increased 49.5% for disposable e-cigarettes, 89.4% for starter kits, and 126.2% for cartridges. Average prices across all product categories increased in convenience stores and decreased in food, drug, and mass merchandisers. Sales and prices varied substantially across states included in the analyses. Sales of all e-cigarette device types grew considerably in convenience stores and food, drug, and mass merchandisers during 2012-2013. The market for e-cigarettes is growing rapidly, resulting in dynamic sales and price changes that vary across the U.S. Continued state-specific surveillance of the e-cigarette market is warranted. Copyright © 2016 American Journal of Preventive Medicine. All rights reserved.

  9. Material specification for ductile cast iron in the United States

    International Nuclear Information System (INIS)

    Sorenson, K.B.

    1987-01-01

    The United States currently does not have formal design criteria for qualifying ductile cast iron (DCI) transportation casks. There is also no dedicated material standard for DCI for this particular application. Recognizing the importance of a material standard for this application, Lawrence Livermore Laboratories, in a report to the NRC, recommended that steps be taken to develop an ASTM material specification suitable for spent fuel shipping containers. A draft ASTM material specification has been written and is currently in the ASTM approval process. This paper reviews the brief history of the development of the specification, the technical basis for the material properties, the ASTM approval process and the current status of the draft specification. The expected implications of having an adopted ASTM specification on the licensing process are also discussed. The relationship of fracture toughness to composition, microstructure and tensile properties has been evaluated at Sandia National Laboratories. The first main conclusion reached is that static fracture toughness is essentially decoupled from tensile properties such as yield strength, tensile strength and ductility. The significance of this finding is that tensile properties provided for in existing DCI specifications should not be used as an indicator of a material's ability to resist crack initiation. A material specification which includes fracture toughness requirements is needed to address the brittle fracture concerns. Second, static fracture toughness was found to correlate well with material microstructure; specifically, graphite nodule count or nodule spacing

  10. Theory and Applications of Discontinuous State Feedback Generating Chaos for Linear Systems

    International Nuclear Information System (INIS)

    Xiao-Dan, Zhang; Zhen, Wang; Pin-Dong, Zhao

    2008-01-01

    We investigate a kind of chaos generating technique on a type of n-dimensional linear differential systems by adding feedback control items under a discontinuous state. This method is checked with some examples of numeric simulation. A constructive theorem is proposed for generalized synchronization related to the above chaotic system

  11. Survey cost of electric power generation from renewable resources in the state of Goias, Brazil

    International Nuclear Information System (INIS)

    Almeida, Ronaldo Pereira de; Bortoni, Edson da Costa; Haddad, Jamil

    2010-01-01

    The work presents a developed study to obtain the investment index costs for renewable based distributed generation in Goias state. A set of renewable resources was selected, along with their availability in each city of the state. Therefore, a rank of investments could be developed. (author)

  12. Shortcuts to adiabatic passage for the generation of a maximal Bell state and W state in an atom–cavity system

    Science.gov (United States)

    Lu, Mei; Chen, Qing-Qin

    2018-05-01

    We propose an efficient scheme to generate the maximal entangle states in an atom–cavity system between two three-level atoms in cavity quantum electronic dynamics system based on shortcuts to adiabatic passage. In the accelerate scheme, there is no need to design a time-varying coupling coefficient for the cavity. We only need to tactfully design time-dependent lasers to drive the system into the desired entangled states. Controlling the detuning between the cavity mode and lasers, we deduce a determinate analysis formula for this quantum information processing. The lasers do not need to distinguish which atom is to be affected, therefore the implementation of the experiment is simpler. The method is also generalized to generate a W state. Moreover, the accelerated program can be extended to a multi-body system and an analytical solution in a higher-dimensional system can be achieved. The influence of decoherence and variations of the parameters are discussed by numerical simulation. The results show that the maximally entangled states can be quickly prepared in a short time with high fidelity, and which are robust against both parameter fluctuations and dissipation. Our study enriches the physics and applications of multi-particle quantum entanglement preparation via shortcuts to adiabatic passage in quantum electronic dynamics.

  13. Reduced waste generation technical work plan

    International Nuclear Information System (INIS)

    1987-05-01

    The United States Department of Energy has established policies for avoiding plutonium losses to the waste streams and minimizing the generation of wastes produced at its nuclear facilities. This policy is evidenced in DOE Order 5820.2, which states ''Technical and administrative controls shall be directed towards reducing the gross volume of TRU waste generated and the amount of radioactivity in such waste.'' To comply with the DOE directive, the Defense Transuranic Waste Program (DTWP) supports and provides funding for specific research and development tasks at the various DOE sites to reduce the generation of waste. This document has been prepared to give an overview of current and past Reduced Waste Generation task activities which are to be based on technical and cost/benefit factors. The document is updated annually, or as needed, to reflect the status of program direction. Reduced Waste Generation (RWG) tasks encompass a wide range of goals which are basically oriented toward (1) avoiding the generation of waste, (2) changing processes or operations to reduce waste, (3) converting TRU waste into LLW by sorting or decontamination, and (4) reducing volumes through operations such as incineration or compaction

  14. Generation of bound states of pulses in a SESAM mode-locked Cr:ZnSe laser

    Science.gov (United States)

    Bu, Xiangbao; Shi, Yuhang; Xu, Jia; Li, Huijuan; Wang, Pu

    2018-06-01

    We report on the generation of bound states of pulses in a SESAM mode-locked Cr:ZnSe laser around 2415 nm. A thulium-doped double-clad fiber laser at 1908 nm was used as the pump source. Bound states with various pulse separations at different dispersion regimes were obtained. Especially, in the anomalous dispersion regime, vibrating bound state of solitons exhibiting an evolving phase was obtained.

  15. 1990 State-by-State assessment of low-level radioactive wastes received at commercial disposal sites

    International Nuclear Information System (INIS)

    Fuchs, R.L.; Culbertson-Arendts, K.

    1991-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This annual report provides both national and state-specific disposal data on low-level radioactive wastes. Data in this report are categorized according to disposal site, generator category, waste class, volume, and activity. Included in this report are tables showing a distribution of wastes by state for 1990 and a comparison of waste volumes by state for 1986 through 1990; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1990. In this year's report, a distinction has been made between low-level radioactive waste shipped directly by generators for disposal and that which was handled by an intermediary. 5 refs., 4 tabs

  16. 1990 State-by-State assessment of low-level radioactive wastes received at commercial disposal sites

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, R.L.; Culbertson-Arendts, K.

    1991-09-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This annual report provides both national and state-specific disposal data on low-level radioactive wastes. Data in this report are categorized according to disposal site, generator category, waste class, volume, and activity. Included in this report are tables showing a distribution of wastes by state for 1990 and a comparison of waste volumes by state for 1986 through 1990; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1990. In this year's report, a distinction has been made between low-level radioactive waste shipped directly by generators for disposal and that which was handled by an intermediary. 5 refs., 4 tabs.

  17. Geothermal energy in the western United States and Hawaii: Resources and projected electricity generation supplies

    International Nuclear Information System (INIS)

    1991-09-01

    Geothermal energy comes from the internal heat of the Earth, and has been continuously exploited for the production of electricity in the United States since 1960. Currently, geothermal power is one of the ready-to-use baseload electricity generating technologies that is competing in the western United States with fossil fuel, nuclear and hydroelectric generation technologies to provide utilities and their customers with a reliable and economic source of electric power. Furthermore, the development of domestic geothermal resources, as an alternative to fossil fuel combustion technologies, has a number of associated environmental benefits. This report serves two functions. First, it provides a description of geothermal technology and a progress report on the commercial status of geothermal electric power generation. Second, it addresses the question of how much electricity might be competitively produced from the geothermal resource base. 19 figs., 15 tabs

  18. Dissipative effects on a generation scheme of a W state in an array of coupled Josephson junctions

    Energy Technology Data Exchange (ETDEWEB)

    Migliore, R [Institute of Biophysics, National Research Council, via Ugo La Malfa 153, 90146 Palermo (Italy); Scala, M; Napoli, A; Messina, A [Dipartimento di Fisica dell' Universita di Palermo, Via Archirafi 36, 90123 Palermo (Italy); Yuasa, K [Waseda Institute for Advanced Study, Waseda University, Tokyo 169-8050 (Japan); Nakazato, H, E-mail: rosanna@fisica.unipa.it, E-mail: matteo.scala@fisica.unipa.it [Department of Physics, Waseda University, Okubo 3-4-1, Shinjuku, Tokyo 169-8555 (Japan)

    2011-04-14

    The dynamics of an open quantum system, consisting of three superconducting qubits interacting with independent reservoirs, is investigated to elucidate the effects of the environment on a unitary generation scheme of W states (Migliore R et al 2006 Phys. Rev. B 74 104503). To this end a microscopic master equation is constructed and its exact resolution predicts the generation of a Werner-like state instead of the W state. A comparison between our model and a more intuitive phenomenological model is also considered, in order to find the limits of the latter approach in the case of structured reservoirs.

  19. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Fisch, N.J.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma

  20. Analog Amplitude Modulation of a High Voltage, Solid State Inductive Adder, Pulse Generator Using MOSFETS

    International Nuclear Information System (INIS)

    Gower, E J; Sullivan, J S

    2002-01-01

    High voltage, solid state, inductive adder, pulse generators have found increasing application as fast kicker pulse modulators for charged particle beams. The solid state, inductive adder, pulse generator is similar in operation to the linear induction accelerator. The main difference is that the solid state, adder couples energy by transformer action from multiple primaries to a voltage summing stalk, instead of an electron beam. Ideally, the inductive adder produces a rectangular voltage pulse at the load. In reality, there is usually some voltage variation at the load due to droop on primary circuit storage capacitors, or, temporal variations in the load impedance. Power MOSFET circuits have been developed to provide analog modulation of the output voltage amplitude of a solid state, inductive adder, pulse generator. The modulation is achieved by including MOSFET based, variable subtraction circuits in the multiple primary stack. The subtraction circuits can be used to compensate for voltage droop, or, to tailor the output pulse amplitude to provide a desired effect in the load. Power MOSFET subtraction circuits have been developed to modulate short, temporal (60-400 ns), voltage and current pulses. MOSFET devices have been tested up to 20 amps and 800 Volts with a band pass of 50 MHz. An analog modulation cell has been tested in a five cell high, voltage adder stack

  1. Functional performance of the helical coil steam generator, Consolidated Nuclear Steam Generator (CNSG) IV system. Executive summary report

    International Nuclear Information System (INIS)

    Watson, G.B.

    1975-10-01

    The objective of this project was to study the functional performance of the CNSG - IV helical steam generator to demonstrate that the generator meets steady-state and transient thermal-hydraulic performance specifications and that secondary flow instability will not be a problem. Economic success of the CNSG concepts depends to a great extent on minimizing the size of the steam generator and the reactor vessel for ship installation. Also, for marine application the system must meet stringent specifications for operating stability, transient response, and control. The full-size two-tube experimental unit differed from the CNSG only in the number of tubes and the mode of primary flow. In general, the functional performance test demonstrated that the helical steam generator concept will exceed the specified superheat of 35F at 100% load. The experimental measured superheat at comparable operating conditions was 95F. Testing also revealed that available computer codes accurately predict trends and overall performance characteristics

  2. Exploiting Stabilizers and Parallelism in State Space Generation with the Symmetry Method

    DEFF Research Database (Denmark)

    Lorentsen, Louise; Kristensen, Lars Michael

    2001-01-01

    The symmetry method is a main reduction paradigm for alleviating the state explosion problem. For large symmetry groups deciding whether two states are symmetric becomes time expensive due to the apparent high time complexity of the orbit problem. The contribution of this paper is to alleviate th...... the negative impact of the orbit problem by the specification of canonical representatives for equivalence classes of states in Coloured Petri Nets, and by giving algorithms exploiting stabilizers and parallelism for computing the condensed state space.......The symmetry method is a main reduction paradigm for alleviating the state explosion problem. For large symmetry groups deciding whether two states are symmetric becomes time expensive due to the apparent high time complexity of the orbit problem. The contribution of this paper is to alleviate...

  3. Smart Home Technologies: Insights into Generation-Specific Acceptance Motives

    Science.gov (United States)

    Gaul, Sylvia; Ziefle, Martina

    In this research we examine the generation specific acceptance motives of eHealth technologies in order to assess the likelihood of success for these new technologies. 280 participants (14 - 92 years of age) volunteered to participate in a survey, in which using motives and barriers toward smart home technologies were explored. The scenario envisaged was the use of a medical stent implemented into the body, which monitors automatically the health status and which is able to remotely communicate with the doctor. Participants were asked to evaluate the pros and cons of the usage of this technology, their acceptance motives and potential utilization barriers. In order to understand the complex nature of acceptance, personal variables (age, technical expertise, health status), individual's cognitive concepts toward ageing as well as perceived usefulness were related. Outcomes show that trust, believe in the reliability of technology, privacy and security as well as intimacy facets are essential for acceptance and should be considered in order to proactively design a successful rollout of smart home technologies.

  4. 'Parity effect' based generation of Schrodinger cat like states in high-Q microcavity

    International Nuclear Information System (INIS)

    Napoli, A.; Messina, A.

    1999-01-01

    It has been very recently shown that the dynamics of a two-level atom coupled to a bimodal degenerate cavity field by two-photon processes, is characterized by an interesting nonclassical dynamical behavior christened ''parity effect''. This effect consists in the fact that if the cavity field is prepared leaving one mode in its vacuum state and exciting the other one in a generic linear combination of even number states only, or odd number states only, then there exists an appropriate intensity-dependent interval of time after which the bimodal cavity exhibits macroscopically different parity-dependent quantum features. We show that this nonclassical effect is at the origin of the possibility of generating Schrodinger cat like states of the bimodal field appropriately selecting its initial conditions

  5. State nuclear initiatives in the United States

    International Nuclear Information System (INIS)

    Strauss, P.L.; Stoiber, C.R.

    1977-01-01

    The paper deals with State nuclear initiatives regarding the role of nuclear power in the energy future of the United States. The question of whether and under what circumstances nuclear facilities should be used to generate electricity was put to the popular vote in several States in 1976. Some general principles of Federal-State relations are discussed with specific reference to nuclear regulations. The initiative mechanism itself is described as well as its legal form and background. The parallel developments in the State and Federal legislative consideration of nuclear issues is reviewed and the suggested reasons for the defeat of the proposals in the seven States concerned are discussed. Finally, the author draws some conclusions on the effects of the 1976 initiatives on future decision-making in the US on energy policy in general and nuclear power in particular. (NEA) [fr

  6. Measuring motivation in schizophrenia: Is a general state of motivation necessary for task-specific motivation?

    Science.gov (United States)

    Choi, Jimmy; Choi, Kee-Hong; Reddy, Felice; Fiszdon, Joanna M.

    2014-01-01

    Despite the important role of motivation in rehabilitation and functional outcomes in schizophrenia, to date, there has been little emphasis on how motivation is assessed. This is important, since different measures may tap potentially discrete motivational constructs, which in turn may have very different associations to important outcomes. In the current study, we used baseline data from 71 schizophrenia spectrum outpatients enrolled in a rehabilitation program to examine the relationship between task-specific motivation, as measured by the Intrinsic Motivation Inventory (IMI), and a more general state of volition/initiation, as measured by the three item Quality of Life (QLS) motivation index. We also examined the relationship of these motivation measures to demographic, clinical and functional variables relevant to rehabilitation outcomes. The two motivation measures were not correlated, and participants with low general state motivation exhibited a full range of task-specific motivation. Only the QLS motivation index correlated with variables relevant to rehabilitation outcomes. The lack of associations between QLS motivation index and IMI subscales suggests that constructs tapped by these measures may be divergent in schizophrenia, and specifically that task-specific intrinsic motivation is not contingent on a general state of motivation. That is, even in individuals with a general low motivational state (i.e. amotivation), interventions aimed at increasing task-specific motivation may still be effective. Moreover, the pattern of interrelationships between the QLS motivation index and variables relevant to psychosocial rehabilitation supports its use in treatment outcome studies. PMID:24529609

  7. Preparation of clinical-scale 99Mo/99mTc column generator using neutron activated low specific activity 99Mo and nanocrystalline γ-Al2O3 as column matrix.

    Science.gov (United States)

    Chakravarty, Rubel; Ram, Ramu; Dash, Ashutosh; Pillai, M R A

    2012-10-01

    Preparation of clinical-scale (99)Mo/(99m)Tc generator using (n,γ) activated low specific activity (99)Mo and nanocrystalline γ-Al(2)O(3) as a high capacity sorbent matrix is attempted. Nanocrystalline γ-Al(2)O(3) was synthesized by 'solid state mechanochemical' reaction of aluminum nitrate with ammonium bicarbonate. Experimental parameters were optimized to effectively separate (99m)Tc from (99)Mo using this sorbent as the column matrix. The performance features of a 13 GBq (350 mCi) (99)Mo/(99m)Tc generator using this sorbent and (99)Mo produced by (n,γ) route having specific activity 12.9-18.5 GBq/g were evaluated for 10 days. The sorbent possessed the requisite selectivity for (99)Mo and demonstrated a maximum sorption capacity of 200 ± 5mg Mo/g, which is ~10 times higher than that of ordinary acidic alumina. The overall yield of (99m)Tc was >80%, with radionuclidic purity >99.99% and radiochemical purity >99%. The yield of (99m)Tc varied from 7.8 to 2.1 GBq in the eluate for the six days of operation of the generator. The radioactive concentration of (99m)Tc eluted was adequate for the formulation of radiopharmaceuticals. The performance of the generator remained consistent over an extended period of 10 days. The eluted (99m)Tc was suitable for the formulation of (99m)Tc-DMSA and (99m)Tc-EC resulting in high radiolabeling yields (>98%). The effectiveness of γ-Al(2)O(3) as a new generation sorbent in the development of clinically useful (99)Mo/(99m)Tc generator using low specific activity (99)Mo and yielding (99m)Tc with adequate radioactive concentration and high purity suitable for formulation of radiopharmaceuticals is demonstrated. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Generation of Elf5-Cre knockin mouse strain for trophoblast-specific gene manipulation.

    Science.gov (United States)

    Kong, Shuangbo; Liang, Guixian; Tu, Zhaowei; Chen, Dunjin; Wang, Haibin; Lu, Jinhua

    2018-04-01

    Placental development is a complex and highly controlled process during which trophoblast stem cells differentiate to various trophoblast subtypes. The early embryonic death of systemic gene knockout models hampers the investigation of these genes that might play important roles during placentation. A trophoblast specific Cre mouse model would be of great help for dissecting out the potential roles of these genes during placental development. For this purpose, we generate a transgenic mouse with the Cre recombinase inserted into the endogenous locus of Elf5 gene that is expressed specifically in placental trophoblast cells. To analyze the specificity and efficiency of Cre recombinase activity in Elf5-Cre mice, we mated Elf5-Cre mice with Rosa26 mT/mG reporter mice, and found that Elf5-Cre transgene is expressed specifically in the trophoectoderm as early as embryonic day 4.5 (E4.5). By E12.5, the activity of Elf5-Cre transgene was detected exclusively in all derivatives of trophoblast lineages, including spongiotrophoblast, giant cells, and labyrinth trophoblasts. In addition, Elf5-Cre transgene was also active during spermatogenesis, from spermatids to mature sperms, which is consistent with the endogenous Elf5 expression in testis. Collectively, our results provide a unique tool to delete specific genes selectively and efficiently in trophoblast lineage during placentation. © 2018 Wiley Periodicals, Inc.

  9. Bell-state generation on remote superconducting qubits with dark photons

    Science.gov (United States)

    Hua, Ming; Tao, Ming-Jie; Alsaedi, Ahmed; Hayat, Tasawar; Wei, Hai-Rui; Deng, Fu-Guo

    2018-06-01

    We present a scheme to generate the Bell state deterministically on remote transmon qubits coupled to different 1D superconducting resonators connected by a long superconducting transmission line. Using the coherent evolution of the entire system in the all-resonance regime, the transmission line need not to be populated with microwave photons which can robust against the long transmission line loss. This lets the scheme more applicable to the distributed quantum computing on superconducting quantum circuit. Besides, the influence from the small anharmonicity of the energy levels of the transmon qubits can be ignored safely.

  10. Climate change impacts on thermoelectric-power generation in the United States

    Science.gov (United States)

    Liu, L.

    2015-12-01

    Thermoelectric-power generation accounts for more than 70% of the total electricity generation in the United States, which requires large amounts of water for cooling purposes. Water withdrawals for thermoelectric-power generation accounted for 45% of total water use in the United States in 2010. Across the country, water demand from power plants is increasing due to pressures from growing populations and other needs, and is straining existing water resources. Moreover, temperature exceedance in receiving waters has increasingly caused power plants shut downs across parts of the country. Thermoelectric power is vulnerable to climate change owing to the combined effects of lower summer river flows and higher receiving water temperatures. In addition, the efficiency of production is reduced as air temperature rises, which propagates to more unfulfilled power demand during peak seasons. Therefore, a holistic modeling framework of water-energy-climate for the contiguous U.S. is presented here to quantify thermal output from power plants and estimate water use and energy production fluctuations due to ambient climate as well as environmental regulations. The model is calibrated on a plant-by-plant basis for year 2010 and 2011 using the available power plant inventory from the Energy Information Administration (EIA). Simulations were carried out for years 2012 and 2013, and results show moderate improvements in capturing thermal output variabilities after calibration. Future power plant operations under scenarios featuring different climate and regulatory settings were investigated. Results demonstrate the interplay among water, energy and climate, and that future changes in climate and socioeconomics significantly affect power plant operations, which may provide insights to climate change mitigation considerations and energy decisions.

  11. Development of all-solid-state flash x-ray generator with photoconductive semiconductor switches

    Energy Technology Data Exchange (ETDEWEB)

    Xun, Ma; Jianjun, Deng; Hongwei, Liu; Jianqiang, Yuan; Jinfeng, Liu; Bing, Wei; Yanling, Qing; Wenhui, Han; Lingyun, Wang; Pin, Jiang; Hongtao, Li [Key Laboratory of Pulsed Power, Institute of Fluid Physics, CAEP, P.O. Box 919-108, Mianyang 621900 (China)

    2014-09-15

    A compact, low-jitter, and high repetitive rate all-solid-state flash x-ray generator making use of photo conductive semiconductor switches was developed recently for the diagnostic purpose of some hydrokinetical experiments. The generator consisted of twelve stages of Blumlein pulse forming networks, and an industrial cold cathode diode was used to generate intense x-ray radiations with photon energy up to 220 keV. Test experiments showed that the generator could produce >1 kA electron beam currents and x-ray pulses with ∼40 ns duration under 100 Hz repetitive rates at least (limited by the triggering laser on hand), also found was that the delay time of the cathode explosive emission is crucial to the energy transfer efficiency of the whole system. In addition, factors affecting the diode impedance, how the switching synchronization and diode impedance determining the allowable operation voltage were discussed.

  12. Development of all-solid-state flash x-ray generator with photoconductive semiconductor switches.

    Science.gov (United States)

    Xun, Ma; Jianjun, Deng; Hongwei, Liu; Jianqiang, Yuan; Jinfeng, Liu; Bing, Wei; Yanling, Qing; Wenhui, Han; Lingyun, Wang; Pin, Jiang; Hongtao, Li

    2014-09-01

    A compact, low-jitter, and high repetitive rate all-solid-state flash x-ray generator making use of photo conductive semiconductor switches was developed recently for the diagnostic purpose of some hydrokinetical experiments. The generator consisted of twelve stages of Blumlein pulse forming networks, and an industrial cold cathode diode was used to generate intense x-ray radiations with photon energy up to 220 keV. Test experiments showed that the generator could produce >1 kA electron beam currents and x-ray pulses with ~40 ns duration under 100 Hz repetitive rates at least (limited by the triggering laser on hand), also found was that the delay time of the cathode explosive emission is crucial to the energy transfer efficiency of the whole system. In addition, factors affecting the diode impedance, how the switching synchronization and diode impedance determining the allowable operation voltage were discussed.

  13. High-Harmonic Generation in Solids with and without Topological Edge States

    Science.gov (United States)

    Bauer, Dieter; Hansen, Kenneth K.

    2018-04-01

    High-harmonic generation in the two topological phases of a finite, one-dimensional, periodic structure is investigated using a self-consistent time-dependent density functional theory approach. For harmonic photon energies smaller than the band gap, the harmonic yield is found to differ by up to 14 orders of magnitude for the two topological phases. This giant topological effect is explained by the degree of destructive interference in the harmonic emission of all valence-band (and edge-state) electrons, which strongly depends on whether or not topological edge states are present. The combination of strong-field laser physics with topological condensed matter opens up new possibilities to electronically control strong-field-based light or particle sources or—conversely—to steer by all optical means topological electronics.

  14. An examination of electricity generation by utility organizations in the Southeast United States

    International Nuclear Information System (INIS)

    Craig, Christopher A.; Feng, Song

    2016-01-01

    This study examined the impact of climatic variability on electricity generation in the Southeast United States. The relationship cooling degree days (CDD) and heating degree days (HDD) shared with electricity generation by fuel source was explored. Using seasonal autoregressive integrated weighted average (ARIMA) and seasonal simple exponentially smoothed models, retrospective time series analysis was run. The hypothesized relationship between climatic variability and total electricity generation was supported, where an ARIMA model including CDDs as a predictor explained 57.6% of the variability. The hypothesis that climatic variability would be more predictive of fossil fuel electricity generation than electricity produced by clean energy sources was partially supported. The ARIMA model for natural gas indicated that CDDS were the only predictor for the fossil fuel source, and that 79.4% of the variability was explained. Climatic variability was not predictive of electricity generation from coal or petroleum, where simple seasonal exponentially smoothed models emerged. However, HDDs were a positive predictor of hydroelectric electricity production, where 48.9% of the variability in the clean energy source was explained by an ARIMA model. Implications related to base load electricity from fossil fuels, and future electricity generation projections relative to extremes and climate change are discussed. - Highlights: • Models run to examine impact of climatic variability on electricity generation. • Cooling degree days explained 57.6% of variability in total electricity generation. • Climatic variability was not predictive of coal or petroleum generation. • Cooling degree days explained 79.4% of natural gas generation. • Heating degree days were predictive of nuclear and hydroelectric generation.

  15. Conditional generation of arbitrary multimode entangled states of light with linear optics

    International Nuclear Information System (INIS)

    Fiurasek, J.; Massar, S.; Cerf, N. J.

    2003-01-01

    We propose a universal scheme for the probabilistic generation of an arbitrary multimode entangled state of light with finite expansion in Fock basis. The suggested setup involves passive linear optics, single-photon sources, strong coherent laser beams, and photodetectors with single-photon resolution. The efficiency of this setup may be greatly enhanced if, in addition, a quantum memory is available

  16. iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

    Directory of Open Access Journals (Sweden)

    Songjie Cai

    2017-05-01

    Full Text Available Regulatory dendritic cell (DCregs-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs, which could remain in a “stable immature stage” even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs, and induced donor-specific allograft acceptance. We immunized naive CBA (H-2Kk mice with B6 (H-2Kb iPS-DCregs and found that Tregs (CD4+CD25+FOXP3+ significantly increased in CBA splenocytes. Moreover, immunized CBA recipients permanently accepted B6 cardiac grafts in a donor-specific pattern. We demonstrated mechanistically that donor-type iPS-DCregs triggered transforming growth factor β1 secretion, under which the donor-antigen peptides directed naive CD4+ T cells to differentiate into donor-specific FOXP3+ Tregs instead of into effector T cells in vivo. These findings highlight the potential of iPS-DCregs as a key cell therapy resource in clinical transplantation.

  17. National and State-Specific Sales and Prices for Electronic Cigarettes—U.S., 2012–2013

    Science.gov (United States)

    Loomis, Brett R.; Rogers, Todd; King, Brian A.; Dench, Daniel L.; Gammon, Doris G.; Fulmer, Erika B.; Agaku, Israel T.

    2015-01-01

    Introduction The growing market for electronic cigarettes (e-cigarettes) has been widely reported in the media, but very little objective data exist in the scientific literature, and no data have been published on state-specific trends in prices or sales. Our objective is to assess state-specific annual sales and average prices for e-cigarettes in the U.S. Methods Commercial retail scanner data were used to assess total dollar sales and average price per unit for disposable e-cigarettes, starter kits, and cartridge refills for selected states and the total U.S. during 2012–2013. Data were analyzed in 2014. Data were available for convenience stores (29 states) and food, drug, and mass merchandisers (44 states). Results In convenience stores, dollar sales increased markedly during 2012–2013: 320.8% for disposable e-cigarettes, 72.4% for starter kits, and 82% for cartridges. In food, drug, and mass merchandisers, dollar sales increased 49.5% for disposable e-cigarettes, 89.4% for starter kits, and 126.2% for cartridges. Average prices across all product categories increased in convenience stores and decreased in food, drug, and mass merchandisers. Sales and prices varied substantially across states included in the analyses. Conclusions Sales of all e-cigarette device types grew considerably in convenience stores and food, drug, and mass merchandisers during 2012–2013. The market for e-cigarettes is growing rapidly, resulting in dynamic sales and price changes that vary across the U.S. Continued state-specific surveillance of the e-cigarette market is warranted. PMID:26163173

  18. A multi state simulation model of the maintenance for a power generating station

    International Nuclear Information System (INIS)

    Karlsson, B.O.

    1980-09-01

    A multistate simulation model for a thermal power generating station is described. The performance is modelled as a function of the system structure, the component reliability, the number of repair crews, the repair times and the availability of spare parts. Each component can be in either of four states: failed, working, postponed, or standby. A component will be in the postponed state, if due to failures in other components it is turned off. Two different types of failures are assumed: minor and severe. Evaluation of the system state is performed by repeated use of four elementary system functions: series, parallel, k-out-of-n, and standby k/l/n. Numerical results for a case study are presented. (author)

  19. Solid-State Power Generating Microdevices for Distributed Space System Architectures

    Science.gov (United States)

    Fleurial, J.-P.; Patel, J.; Snyder, G. J.; Huang, C.-K.; Averback, R.; Hill, C.; Chen, G.

    2001-01-01

    Deep space missions have a strong need for compact, high power density, reliable and long life electrical power generation and storage under extreme temperature conditions. Conventional power generating devices become inefficient at very low temperatures (temperatures lower than 200 K encountered during Mars missions for example) and rechargeable energy storage devices cannot be operated thereby limiting mission duration. At elevated temperatures (for example for planned solar probe or Venus lander missions), thin film interdiffusion destroys electronic devices used for generating and storing power. Solar power generation strongly depends upon the light intensity, which falls rapidly in deep interplanetary missions (beyond 5 AU), and in planetary missions in the sun shadow or in dusty environments (Mars, for example). Radioisotope thermoelectric generators (RTGs) have been successfully used for a number of deep space missions RTGs. However, their energy conversion efficiency and specific power characteristics are quite low, and this technology has been limited to relatively large systems (more than 100 W). The National Aeronautics and Space Administration (NASA) and the Jet Propulsion Laboratory (JPL) have been planning the use of much smaller spacecrafts that will incorporate a variety of microdevices and miniature vehicles such as microdetectors, microsensors, and microrovers. Except for electrochemical batteries and solar cells, there are currently no available miniaturized power sources. Novel technologies that will function reliably over a long duration mission (ten years and over), in harsh environments (temperature, pressure, and atmosphere) must be developed to enable the success of future space missions. It is also expected that such micropower sources could have a wide range of terrestrial applications, in particular when the limited lifetime and environmental limitations of batteries are key factors. Additional information is contained in the original

  20. Generation of Atomic Greenberger-Horne-Zeilinger States Based on Faraday Rotation

    International Nuclear Information System (INIS)

    Liang Honghui; Li Xinghua

    2010-01-01

    Based on the input-output relation of the cavity and the Faraday Rotation mechanism, we propose a scheme for generating the n-atom Greenberger-Horne-Zeilinger state. In the scheme, the n-atom trapped respectively in n spatially separate cavities would be entangled with the photons going through the atom-cavity system. The successful probabilities of our protocol approach unity in the ideal case. What is more, no requirement for separately addressing further lowers experimental difficulties. (general)

  1. All-organic microelectromechanical systems integrating specific molecular recognition--a new generation of chemical sensors.

    Science.gov (United States)

    Ayela, Cédric; Dubourg, Georges; Pellet, Claude; Haupt, Karsten

    2014-09-03

    Cantilever-type all-organic microelectromechanical systems based on molecularly imprinted polymers for specific analyte recognition are used as chemical sensors. They are produced by a simple spray-coating-shadow-masking process. Analyte binding to the cantilever generates a measurable change in its resonance frequency. This allows label-free detection by direct mass sensing of low-molecular-weight analytes at nanomolar concentrations. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Finite element speaker-specific face model generation for the study of speech production.

    Science.gov (United States)

    Bucki, Marek; Nazari, Mohammad Ali; Payan, Yohan

    2010-08-01

    In situations where automatic mesh generation is unsuitable, the finite element (FE) mesh registration technique known as mesh-match-and-repair (MMRep) is an interesting option for quickly creating a subject-specific FE model by fitting a predefined template mesh onto the target organ. The irregular or poor quality elements produced by the elastic deformation are corrected by a 'mesh reparation' procedure ensuring that the desired regularity and quality standards are met. Here, we further extend the MMRep capabilities and demonstrate the possibility of taking into account additional relevant anatomical features. We illustrate this approach with an example of biomechanical model generation of a speaker's face comprising face muscle insertions. While taking advantage of the a priori knowledge about tissues conveyed by the template model, this novel, fast and automatic mesh registration technique makes it possible to achieve greater modelling realism by accurately representing the organ surface as well as inner anatomical or functional structures of interest.

  3. Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors

    Directory of Open Access Journals (Sweden)

    Linda H. Kim

    2017-10-01

    Full Text Available Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating work from both the locomotor and animal behavioral fields, we can now examine context-specific control of locomotion, with an emphasis on descending modulation arising from various regions of the brainstem. Here we examine approach and avoidance behaviors and the circuits that lead to the production and arrest of locomotion.

  4. Organism-specific rRNA capture system for application in next-generation sequencing.

    Directory of Open Access Journals (Sweden)

    Sai-Kam Li

    Full Text Available RNA-sequencing is a powerful tool in studying RNomics. However, the highly abundance of ribosomal RNAs (rRNA and transfer RNA (tRNA have predominated in the sequencing reads, thereby hindering the study of lowly expressed genes. Therefore, rRNA depletion prior to sequencing is often performed in order to preserve the subtle alteration in gene expression especially those at relatively low expression levels. One of the commercially available methods is to use DNA or RNA probes to hybridize to the target RNAs. However, there is always a concern with the non-specific binding and unintended removal of messenger RNA (mRNA when the same set of probes is applied to different organisms. The degree of such unintended mRNA removal varies among organisms due to organism-specific genomic variation. We developed a computer-based method to design probes to deplete rRNA in an organism-specific manner. Based on the computation results, biotinylated-RNA-probes were produced by in vitro transcription and were used to perform rRNA depletion with subtractive hybridization. We demonstrated that the designed probes of 16S rRNAs and 23S rRNAs can efficiently remove rRNAs from Mycobacterium smegmatis. In comparison with a commercial subtractive hybridization-based rRNA removal kit, using organism-specific probes is better in preserving the RNA integrity and abundance. We believe the computer-based design approach can be used as a generic method in preparing RNA of any organisms for next-generation sequencing, particularly for the transcriptome analysis of microbes.

  5. Establishment of database and network for research of stream generator and state of the art technology review

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jae Bong; Hur, Nam Su; Moon, Seong In; Seo, Hyeong Won; Park, Bo Kyu; Park, Sung Ho; Kim, Hyung Geun [Sungkyunkwan Univ., Seoul (Korea, Republic of)

    2004-02-15

    A significant number of steam generator tubes are defective and are removed from service or repaired world widely. This wide spread damage has been caused by diverse degradation mechanisms, some of which are difficult to detect and predict. Regarding domestic nuclear power plants, also, the increase of number of operating nuclear power plants and operating periods may result in the increase of steam generator tube failure. So, it is important to carry out the integrity evaluation process to prevent the steam generator tube damage. There are two objectives of this research. The one is to make database for the research of steam generator at domestic research institution. It will increase the efficiency and capability of limited domestic research resources by sharing data and information through network organization. Also, it will enhance the current standard of integrity evaluation procedure that is considerably conservative but can be more reasonable. The second objective is to establish the standard integrity evaluation procedure for steam generator tube by reviewing state of the art technology. The research resources related to steam generator tubes are managed by the established web-based database system. The following topics are covered in this project: development of web-based network for research on steam generator tubes review of state of the art technology.

  6. Establishment of database and network for research of stream generator and state of the art technology review

    International Nuclear Information System (INIS)

    Choi, Jae Bong; Hur, Nam Su; Moon, Seong In; Seo, Hyeong Won; Park, Bo Kyu; Park, Sung Ho; Kim, Hyung Geun

    2004-02-01

    A significant number of steam generator tubes are defective and are removed from service or repaired world widely. This wide spread damage has been caused by diverse degradation mechanisms, some of which are difficult to detect and predict. Regarding domestic nuclear power plants, also, the increase of number of operating nuclear power plants and operating periods may result in the increase of steam generator tube failure. So, it is important to carry out the integrity evaluation process to prevent the steam generator tube damage. There are two objectives of this research. The one is to make database for the research of steam generator at domestic research institution. It will increase the efficiency and capability of limited domestic research resources by sharing data and information through network organization. Also, it will enhance the current standard of integrity evaluation procedure that is considerably conservative but can be more reasonable. The second objective is to establish the standard integrity evaluation procedure for steam generator tube by reviewing state of the art technology. The research resources related to steam generator tubes are managed by the established web-based database system. The following topics are covered in this project: development of web-based network for research on steam generator tubes review of state of the art technology

  7. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 4

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator are documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This volume contains 5 books of which this is the fourth, providing drawings 47A380128 through 47A387125. In addition to the parts listing and where-used list, the logic design of the controller software and the code listing of the controller software are provided. Also given are the aerodynamic profile coordinates.

  8. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 2

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the second book of volume four. Some of the items it contains are specs for the emergency shutdown panel, specs for the simulator software, simulator hardware specs, site operator terminal requirements, control data system requirements, software project management plan, elastomeric teeter bearing requirement specs, specs for the controls electronic cabinet, and specs for bolt pretensioning.

  9. Power utility generation portfolio optimization as function of specific RES and decarbonisation targets – EPBiH case study

    International Nuclear Information System (INIS)

    Kazagic, Anes; Merzic, Ajla; Redzic, Elma; Music, Mustafa

    2014-01-01

    Highlights: • Guidelines for power utilities to reach specific decarbonisation targets offered. • Optimization model of RES share to be introduced into power system is proposed. • Single criteria analysis and multicriteria sustainability assessment are applied. • The optimization method has been demonstrated on a real power system. • In the considered case, HIGH RES scenario showed to be the preferable one. - Abstract: This paper provides guidelines and principles for power utilities to reach specific energy and decarbonisation targets. Method of power generation portfolio optimization, as function of sustainability and decarbonisation, along with appropriate criteria, has been proposed. Application of this optimization method has been demonstrated on a real power system – power utility JP Elektroprivreda BiH d.d. – Sarajevo (EPBiH), a typical example of South East European power system. The software tool WASP IV has been employed in the analysis, in order to define the dynamics and an optimized expansion of generation portfolio of the power system under consideration for the next period. The mid-term generation portfolio development plan for the EPBiH power system until year 2030 has been made during this research, taking into account the shutdown dynamics of existing power units and commissioning new ones, in order to provide safe supply of electric and heat energy for local consumers. Three basic scenario of renewable energy sources (RES) expansion have been analysed to reach specific RES and decarbonisation targets set for 2030, including RES share increase from the current level of 18% up to 35% (LOW RES), 45% (MID RES) and 55% (HIGH RES). Effects to the sustainability are considered through environmental, economic and social indicators. Multicriteria sustainability assessment gave an advantage to the HIGH RES, under assumption of equal weighting factors of economic and environment groups of indicators. Also, single criteria analysis has been

  10. Propensity score estimation to address calendar time-specific channeling in comparative effectiveness research of second generation antipsychotics.

    Directory of Open Access Journals (Sweden)

    Stacie B Dusetzina

    Full Text Available Channeling occurs when a medication and its potential comparators are selectively prescribed based on differences in underlying patient characteristics. Drug safety advisories can provide new information regarding the relative safety or effectiveness of a drug product which might increase selective prescribing. In particular, when reported adverse effects vary among drugs within a therapeutic class, clinicians may channel patients toward or away from a drug based on the patient's underlying risk for an adverse outcome. If channeling is not identified and appropriately managed it might lead to confounding in observational comparative effectiveness studies.To demonstrate channeling among new users of second generation antipsychotics following a Food and Drug Administration safety advisory and to evaluate the impact of channeling on cardiovascular risk estimates over time.Florida Medicaid data from 2001-2006.Retrospective cohort of adults initiating second generation antipsychotics. We used propensity scores to match olanzapine initiators with other second generation antipsychotic initiators. To evaluate channeling away from olanzapine following an FDA safety advisory, we estimated calendar time-specific propensity scores. We compare the performance of these calendar time-specific propensity scores with conventionally-estimated propensity scores on estimates of cardiovascular risk.Increased channeling away from olanzapine was evident for some, but not all, cardiovascular risk factors and corresponded with the timing of the FDA advisory. Covariate balance was optimized within period and across all periods when using the calendar time-specific propensity score. Hazard ratio estimates for cardiovascular outcomes did not differ across models (Conventional PS: 0.97, 95%CI: 0.81-3.18 versus calendar time-specific PS: 0.93, 95%CI: 0.77-3.04.Changes in channeling over time was evident for several covariates but had limited impact on cardiovascular risk

  11. Radiation-induced interface state generation in MOS devices with reoxidised nitrided SiO2 gate dielectrics

    International Nuclear Information System (INIS)

    Lo, G.Q.; Shih, D.K.; Ting, W.; Kwong, D.L.

    1989-01-01

    In this letter, the radiation-induced interface state generation ΔD it in MOS devices with reoxidised nitrided gate oxides has been studied. The reoxidised nitrided oxides were fabricated by rapid thermal reoxidation (RTO) of rapidly thermal nitrided (RTN) SiO 2 . The devices were irradiated by exposure to X-rays at doses of 0.5-5.0 Mrad (Si). It is found that the RTO process improves the radiation hardness of RTN oxides in terms of interface state generation. The enhanced interface ''hardness'' of reoxidised nitrided oxides is attributed to the strainless interfacial oxide regrowth or reduction of hydrogen concentration during RTO of RTN oxides. (author)

  12. Reduced brain resting-state network specificity in infants compared with adults

    Directory of Open Access Journals (Sweden)

    Wylie KP

    2014-07-01

    Full Text Available Korey P Wylie,1,* Donald C Rojas,1,* Randal G Ross,1 Sharon K Hunter,1 Keeran Maharajh,1 Marc-Andre Cornier,2 Jason R Tregellas1,3 1Department of Psychiatry, 2Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 3Denver Veterans Affairs Medical Center, Denver, CO, USA *These authors contributed equally to this work Purpose: Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults.Patients and methods: Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups.Results: Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults.Conclusion: We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience. Keywords: functional connectivity magnetic resonance imaging

  13. Diversity of fuel sources for electricity generation in an evolving U.S. power sector

    Science.gov (United States)

    DiLuccia, Janelle G.

    Policymakers increasingly have shown interest in options to boost the relative share of renewable or clean electricity generating sources in order to reduce negative environmental externalities from fossil fuels, guard against possible resource constraints, and capture economic advantages from developing new technologies and industries. Electric utilities and non-utility generators make decisions regarding their generation mix based on a number of different factors that may or may not align with societal goals. This paper examines the makeup of the electric power sector to determine how the type of generator and the presence (or lack) of competition in electricity markets at the state level may relate to the types of fuel sources used for generation. Using state-level electricity generation data from the U.S. Energy Information Administration from 1990 through 2010, this paper employs state and time fixed-effects regression modeling to attempt to isolate the impacts of state-level restructuring policies and the emergence of non-utility generators on states' generation from coal, from fossil fuel and from renewable sources. While the analysis has significant limitations, I do find that state-level electricity restructuring has a small but significant association with lowering electricity generation from coal specifically and fossil fuels more generally. Further research into the relationship between competition and fuel sources would aid policymakers considering legislative options to influence the generation mix.

  14. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

    Science.gov (United States)

    Kim, Jong Wook; Abudayyeh, Omar O; Yeerna, Huwate; Yeang, Chen-Hsiang; Stewart, Michelle; Jenkins, Russell W; Kitajima, Shunsuke; Konieczkowski, David J; Medetgul-Ernar, Kate; Cavazos, Taylor; Mah, Clarence; Ting, Stephanie; Van Allen, Eliezer M; Cohen, Ofir; Mcdermott, John; Damato, Emily; Aguirre, Andrew J; Liang, Jonathan; Liberzon, Arthur; Alexe, Gabriella; Doench, John; Ghandi, Mahmoud; Vazquez, Francisca; Weir, Barbara A; Tsherniak, Aviad; Subramanian, Aravind; Meneses-Cime, Karina; Park, Jason; Clemons, Paul; Garraway, Levi A; Thomas, David; Boehm, Jesse S; Barbie, David A; Hahn, William C; Mesirov, Jill P; Tamayo, Pablo

    2017-08-23

    The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. We applied the methodology to the RAS pathway and identified nine distinct components that reflect transcriptional activities downstream of RAS and defined several functional states associated with patterns of transcriptional component activation that associates with genomic hallmarks and response to genetic and pharmacological perturbations. These results show that the Onco-GPS is an effective approach to explore the complex landscape of oncogenic cellular states across cancers, and an analytic framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. 78 FR 17652 - Tri-State Generation and Transmission Association, Inc. v. Public Service Company of New Mexico...

    Science.gov (United States)

    2013-03-22

    ... Generation and Transmission Association, Inc. v. Public Service Company of New Mexico; Notice of Complaint... CFR 385.206 and 18 CFR 385.212, Tri-State Generation and Transmission Association, Inc. (Complainant), filed a complaint against the Public Service Company of New Mexico (Respondent or PNM) alleging that...

  16. Deterministic Generation of Quantum State Transfer Between Spatially Separated Single Molecule Magnets

    International Nuclear Information System (INIS)

    Song Peijun; Lue Xinyou; Huang Pei; Hao Xiangying; Yang Xiaoxue

    2010-01-01

    We propose a new scheme for realizing deterministic quantum state transfer (QST) between two spatially separated single molecule magnets (SMMs) with the framework of cavity quantum electrodynamics (QED). In the present scheme, two SMMs are trapped in two spatially separated optical cavities coupled by an optical fiber. Through strictly numerically simulating, we demonstrate that our scheme is robust with respect to the SMMs' spontaneous decay and fiber loss under the conditions of dispersive SMMs-field interaction and strong coupling of cavity fiber. In addition, we also discuss the influence of photon leakage out of cavities and show that our proposal is good enough to demonstrate the generation of QST with high fidelity utilizing the current experimental technology. The present investigation provides research opportunities for realizing QST between solid-state qubits and may result in a substantial impact on the progress of solid-state-based quantum communications network. (general)

  17. Normative Trimester-Specific Thyroid Function Data from India: The State of the Nation

    OpenAIRE

    Subramanian Kannan; Sanjay Kalra

    2018-01-01

    Background: International guidelines recommend using local trimester-specific normative data for TSH (thyroid stimulating hormone). However, there are no unified Indian data for the same. Material and Methods: This review collates recently published data from various Indian centres and discusses the state of trimester-specific TSH ranges in the country. Results: The authors describe the strengths and limitations of available data, and support the need for pan-India data. Conclusion: To ensure...

  18. Withdrawal of voluntary inhibition unravels the off state of the spontaneous blink generator.

    Science.gov (United States)

    Moraitis, Timoleon; Ghosh, Arko

    2014-12-01

    Involuntary movements such as spontaneous eye blinks can be successfully inhibited at will. Little do we know how the voluntary motor circuits countermand spontaneous blinks. Do the voluntary inhibitory commands act to pause or to turn off the endogenous blink generator, or does inhibition intersect and counter the generator׳s excitatory outputs? In theory, the time taken for the system to generate an after-inhibition blink will reflect onto the form of inhibition. For instance, if voluntary commands were to turn the blink generator off then the after-blink latency would be fixed to the inhibition offset and reflect the time it takes for the generator to rebound and turn on. In this study we measured the after-blink latency from the offset of voluntary inhibition. Volunteers inhibited their blinks in response to sound tones of randomly varying durations. At the offset volunteers withdrew the inhibition and relaxed. Interestingly, the spontaneous after-blinks were fixed to the offset of the inhibition as if the generator rebounded from an off state. The after-blink latency was not related to the duration of the inhibition, and inhibiting even for a small fraction of the mean inter-blink interval generated an after-blink time-locked to the inhibition offset. Interestingly, the insertion of voluntary blinks after inhibition further altered the blink generator by delaying the spontaneous after-blinks. We propose that the inhibition of spontaneous blinks at the level of the generator allows for highly effective voluntary countermanding. Nevertheless, the withdrawal of such inhibition was strongly associated with motor excitation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Evolving Distributed Generation Support Mechanisms: Case Studies from United States, Germany, United Kingdom, and Australia

    Energy Technology Data Exchange (ETDEWEB)

    Lowder, Travis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tian, Tian [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-03-14

    This report expands on a previous National Renewable Energy Laboratory (NREL) technical report (Lowder et al. 2015) that focused on the United States' unique approach to distributed generation photovoltaics (DGPV) support policies and business models. While the focus of that report was largely historical (i.e., detailing the policies and market developments that led to the growth of DGPV in the United States), this report looks forward, narrating recent changes to laws and regulations as well as the ongoing dialogues over how to incorporate distributed generation (DG) resources onto the electric grid. This report also broadens the scope of Lowder et al. (2015) to include additional countries and technologies. DGPV and storage are the principal technologies under consideration (owing to market readiness and deployment volumes), but the report also contemplates any generation resource that is (1) on the customer side of the meter, (2) used to, at least partly, offset a host's energy consumption, and/or (3) potentially available to provide grid support (e.g., through peak shaving and load shifting, ancillary services, and other means).

  20. Automatic generation of gene finders for eukaryotic species

    DEFF Research Database (Denmark)

    Terkelsen, Kasper Munch; Krogh, A.

    2006-01-01

    and quality of reliable gene annotation grows. Results We present a procedure, Agene, that automatically generates a species-specific gene predictor from a set of reliable mRNA sequences and a genome. We apply a Hidden Markov model (HMM) that implements explicit length distribution modelling for all gene......Background The number of sequenced eukaryotic genomes is rapidly increasing. This means that over time it will be hard to keep supplying customised gene finders for each genome. This calls for procedures to automatically generate species-specific gene finders and to re-train them as the quantity...... structure blocks using acyclic discrete phase type distributions. The state structure of the each HMM is generated dynamically from an array of sub-models to include only gene features represented in the training set. Conclusion Acyclic discrete phase type distributions are well suited to model sequence...

  1. Generation of a Kind of Displaced Thermal States in the Diffusion Process and its Statistical Properties

    Science.gov (United States)

    Xiang-Guo, Meng; Hong-Yi, Fan; Ji-Suo, Wang

    2018-04-01

    This paper proposes a kind of displaced thermal states (DTS) and explores how this kind of optical field emerges using the entangled state representation. The results show that the DTS can be generated by a coherent state passing through a diffusion channel with the diffusion coefficient ϰ only when there exists κ t = (e^{\\hbar ν /kBT} - 1 )^{-1}. Also, its statistical properties, such as mean photon number, Wigner function and entropy, are investigated.

  2. The German Birth Order Register - order-specific data generated from perinatal statistics and statistics on out-of-hospital births 2001-2008

    OpenAIRE

    Michaela Kreyenfeld; Rembrandt D. Scholz; Frederik Peters; Ines Wlosnewski

    2010-01-01

    Until 2008, Germany’s vital statistics did not include information on the biological order of each birth. This resulted in a dearth of important demographic indicators, such as the mean age at first birth and the level of childlessness. Researchers have tried to fill this gap by generating order-specific birth rates from survey data, and by combining survey data with vital statistics. This paper takes a different approach by using hospital statistics on births to generate birth order-specific...

  3. Short-pulse generation in a diode-end-pumped solid-state laser

    CSIR Research Space (South Africa)

    Ngcobo, S

    2010-09-01

    Full Text Available , Development of High Average Power Picosecond Laser Systems, Opto- Electronic Devices, (2002). INTRODUCTION A Nd:YVO4 modelocked laser has been constructed using a resonator designed according to the theoretical parameters. The laser produced pulses... theoretical PQSML,th of 2.08W. Short-Pulse Generation in a Diode-End-Pumped Solid-State Laser S. Ngcobo1,2, C. Bollig1 and H. Von Bergmann2 1CSIR National Laser Centre, PO Box 395, Pretoria, 0001, South Africa 2Laser Research Center, University...

  4. The role of stimulus-specific adaptation in songbird syntax generation

    Science.gov (United States)

    Wittenbach, Jason D.

    Sequential behaviors are an important part of the behavioral repertoire of many animals and understanding how neural circuits encode and generate such sequences is a long-standing question in neuroscience. The Bengalese finch is a useful model system for studying variable action sequences. The songs of these birds consist of well-defined vocal elements (syllables) that are strung together to form sequences. The ordering of the syllables within the sequence is variable but not random - it shows complex statistical patterns (syntax). While often thought to be first-order, the syntax of the Bengalese finch song shows a distinct form of history dependence where the probability of repeating a syllable decreases as a function of the number of repetitions that have already occurred. Current models of the Bengalese finch song control circuitry offer no explanation for this repetition adaptation. The Bengalese finch also uses real-time auditory feedback to control the song syntax. Considering these facts, we hypothesize that repetition adaptation in the Bengalese finch syntax may be caused by stimulus-specific adaptation - a wide-spread phenomenon where neural responses to a specific stimulus become weaker with repeated presentations of the same stimulus. We begin by proposing a computational model for the song-control circuit where an auditory feedback signal that undergoes stimulus-specific adaptation helps drive repeated syllables. We show that this model does indeed capture the repetition adaptation observed in Bengalese finch syntax; along the way, we derive a new probabilistic model for repetition adaptation. Key predictions of our model are analyzed in light of experiments performed by collaborators. Next we extend the model in order to predict how the syntax will change as a function of brain temperature. These predictions are compared to experimental results from collaborators where portions of the Bengalese finch song circuit are cooled in awake and behaving birds

  5. Generation of Arbitrary Pure States for Three-dimensional Motion of a Trapped Ion

    International Nuclear Information System (INIS)

    Li Dachuang; Dong Ping; Cao Zhuoliang; Wang Xianping; Yang Ming

    2010-01-01

    In this paper, we propose a scheme for generating an arbitrary three-dimensional pure state of vibrational motion of a trapped ion. Our scheme is based on a sequence of laser pulses, which are tuned to the appropriate vibrational sidebands with respect to the appropriate electronic transition. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  6. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    Directory of Open Access Journals (Sweden)

    Hettne Kristina M

    2013-01-01

    Full Text Available Abstract Background Availability of chemical response-specific lists of genes (gene sets for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM, and that these can be used with gene set analysis (GSA methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. Methods We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human and 588 (mouse gene sets from the Comparative Toxicogenomics Database (CTD. We tested for significant differential expression (SDE (false discovery rate -corrected p-values Results Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Conclusions Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect.

  7. New York State's low-level radioactive waste storage study

    International Nuclear Information System (INIS)

    Spath, John P.

    1992-01-01

    Like their counterparts in other states, low-level radioactive waste (LLRW) generators in New York State face the prospect of being unable to transfer their LLRW off site beginning January 1, 1993. How long will those generators be able to accumulate and store LLRW on site before activities producing the waste are seriously interrupted? Would a centralized storage facility be a more economically viable solution for medical and academic institutions? The New York State Energy Research and Development Authority is conducting a study that seeks to answer these and a variety of related questions over the coming year. This paper describes the origin and design of the study. It reviews the plans for generator-specific data collection, the method for assessing generator storage capability, and the approach to evaluating economic viability. In pursuing this study, the Energy Authority has attempted to incorporate the views of the broad spectrum of LLRW interests. The formation and role of the Study Review Panel, established specifically for that purpose, is discussed. Finally, the paper reviews some of the more interesting questions and issues raised in the development of the study and relates the study to the State's other LLRW management activities, particularly its Interim LLRW Management Plan. (author)

  8. Hypothetical Scenario Generator for Fault-Tolerant Diagnosis

    Science.gov (United States)

    James, Mark

    2007-01-01

    The Hypothetical Scenario Generator for Fault-tolerant Diagnostics (HSG) is an algorithm being developed in conjunction with other components of artificial- intelligence systems for automated diagnosis and prognosis of faults in spacecraft, aircraft, and other complex engineering systems. By incorporating prognostic capabilities along with advanced diagnostic capabilities, these developments hold promise to increase the safety and affordability of the affected engineering systems by making it possible to obtain timely and accurate information on the statuses of the systems and predicting impending failures well in advance. The HSG is a specific instance of a hypothetical- scenario generator that implements an innovative approach for performing diagnostic reasoning when data are missing. The special purpose served by the HSG is to (1) look for all possible ways in which the present state of the engineering system can be mapped with respect to a given model and (2) generate a prioritized set of future possible states and the scenarios of which they are parts.

  9. Evaluation of highly loaded low specific activity 99Mo on alumina column as 99mTc generator

    International Nuclear Information System (INIS)

    Asif, M.; Mushtaq, A.

    2010-01-01

    Adsorption behavior of molybdate on acidic alumina was studied at boiling water bath temperature (∼100 deg C). Various parameters affecting the adsorption of molybdenum, such as pH, amount of molybdenum, incubation period, etc., were determined. A 99m Tc generator was prepared by adsorbing low specific activity 99 Mo (150 mg) on 1 g alumina. Elutions were carried out with saline. Performance of the generator such as 99 Mo breakthrough, aluminum contents, pH, elution profile, radiochemical purity, and labeling efficiency of kits were checked. (author)

  10. Next Generation Science Standards and edTPA: Evidence of Science and Engineering Practices

    Science.gov (United States)

    Brownstein, Erica M.; Horvath, Larry

    2016-01-01

    Science teacher educators in the United States are currently preparing future science teachers to effectively implement the "Next Generation Science Standards" (NGSS) and, in thirteen states, to successfully pass a content-specific high stakes teacher performance assessment, the edTPA. Science education and teacher performance assessment…

  11. 1997 State-by-State Assessment of Low-Level Radioactive Wastes Received at Commercial Disposal Sites

    International Nuclear Information System (INIS)

    Fuchs, R. L.

    1998-01-01

    Each year the National Low-Level Waste Management Program publishes a state-by-state assessment report. This report provides both national and state-specific disposal data on low-level radioactive waste commercially disposed in the United States. Data in this report are categorized according to disposal site, generator category, waste class, volumes, and radionuclide activity. Included in this report are tables showing the distribution of waste by state for 1997 and a comparison of waste volumes and radioactivity by state for 1993 through 1997; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1997

  12. 1989 state-by-state assessment of low-level radioactive wastes received at commercial disposal sites: National Low-Level Waste Management Program

    International Nuclear Information System (INIS)

    Fuchs, R.L.; Culbertson-Arendts, K.

    1990-12-01

    The National Low-Level Waste Management Program has published eleven annual state-by-state assessment reports. These reports provide both national and state-specific disposal data on low-level radioactive wastes. Data in this report are divided into generator category, waste class, volume, and activity. Included in this report are tables showing a distribution of wastes by state for 1989 and a comparison of waste volumes by state for 1985 through 1989; also included is a list of all commercial nuclear power reactors in the United States as of December 31, 1989. In this year's report, a distinction has been made between low-level radioactive waste shipped directly for disposal by generators and that handled by an intermediary. 7 refs., 4 tabs

  13. Magnetohydrodynamic power generation

    International Nuclear Information System (INIS)

    Sheindlin, A.E.; Jackson, W.D.; Brzozowski, W.S.; Rietjens, L.H.Th.

    1979-01-01

    The paper describes research and development in the field of magnetohydrodynamic power generation technology, based on discussions held in the Joint IAEA/UNESCO International Liaison Group on MHD electrical power generation. Research and development programmes on open cycle, closed cycle plasma and liquid-metal MHD are described. Open cycle MHD has now entered the engineering development stage. The paper reviews the results of cycle analyses and economic and environmental evaluations: substantial agreement has been reached on the expected overall performance and necessary component specifications. The achievement in the Soviet Union on the U-25 MHD pilot plant in obtaining full rated electrical power of 20.4 MW is described, as well as long duration testing of the integrated operation of MHD components. Work in the United States on coal-fired MHD generators has shown that, with slagging of the walls, a run time of about one hundred hours at the current density and electric field of a commercial MHD generator has been achieved. Progress obtained in closed cycle plasma and liquid metal MHD is reviewed. Electrical power densities of up to 140 MWe/m 3 and an enthalpy extraction as high as 24 per cent have been achieved in noble gas MHD generator experiments. (Auth.)

  14. Generation of four-atom Greenberger—Horn—Zeilinger state via adiabatic passage

    International Nuclear Information System (INIS)

    Zhang Chun-Ling; Chen Mei-Feng

    2013-01-01

    We propose a scheme to generate a Greenberger—Horn—Zeilinger (GHZ) state of four atoms trapped in a two-mode optical cavity via an adiabatic passage. The scheme is robust against moderate fluctuations of the experimental parameters. Numerical calculations show that the excited probabilities of both the cavity modes and the atoms are tiny and depend on the pulse peaks of the classical laser fields. For certain decoherence due to the atomic spontaneous emission and the cavity decay, there exits a range of pulse peaks to get a high fidelity. (general)

  15. Secondary immunization generates clonally related antigen-specific plasma cells and memory B cells.

    Science.gov (United States)

    Frölich, Daniela; Giesecke, Claudia; Mei, Henrik E; Reiter, Karin; Daridon, Capucine; Lipsky, Peter E; Dörner, Thomas

    2010-09-01

    Rechallenge with T cell-dependent Ags induces memory B cells to re-enter germinal centers (GCs) and undergo further expansion and differentiation into plasma cells (PCs) and secondary memory B cells. It is currently not known whether the expanded population of memory B cells and PCs generated in secondary GCs are clonally related, nor has the extent of proliferation and somatic hypermutation of their precursors been delineated. In this study, after secondary tetanus toxoid (TT) immunization, TT-specific PCs increased 17- to 80-fold on days 6-7, whereas TT-specific memory B cells peaked (delayed) on day 14 with a 2- to 22-fold increase. Molecular analyses of V(H)DJ(H) rearrangements of individual cells revealed no major differences of gene usage and CDR3 length between TT-specific PCs and memory B cells, and both contained extensive evidence of somatic hypermutation with a pattern consistent with GC reactions. This analysis identified clonally related TT-specific memory B cells and PCs. Within clusters of clonally related cells, sequences shared a number of mutations but also could contain additional base pair changes. The data indicate that although following secondary immunization PCs can derive from memory B cells without further somatic hypermutation, in some circumstances, likely within GC reactions, asymmetric mutation can occur. These results suggest that after the fate decision to differentiate into secondary memory B cells or PCs, some committed precursors continue to proliferate and mutate their V(H) genes.

  16. Mexican Ancestry, Immigrant Generation, and Educational Attainment in the United States

    Directory of Open Access Journals (Sweden)

    Stephen L. Morgan

    2014-09-01

    Full Text Available After introducing alternative perspectives on assimilation and acculturation, we use the 2002-2012 waves of the Education Longitudinal Study to model differences in educational attainment for students sampled as high school sophomores in 2002. We focus on patterns observed for the growing Mexican immigrant population, analyzing separately the trajectories of 1st, 1.5th, 2nd, and 3rd+ generation Mexican immigrant students, in comparison to 3rd+ generation students who self-identify as non-Hispanic whites and students who self-identify as non-Hispanic blacks or African Americans. The results suggest that the dissonant acculturation mechanism associated with the segmented assimilation perspective is mostly unhelpful for explaining patterns of educational attainment, especially for the crucial groups of 1.5th and 2nd generation Mexican immigrant students. Instead, standard measures of family background can account for large portions of group differences in bachelor’s degree attainment, with or without additional adjustments for behavioral commitment to schooling, occupational plans, and educational expectations. The broad structure of inequality in the United States, as well as the rising costs of bachelor’s degrees, should be the primary source of concern when considering the prospects for the incorporation of the children of recent Mexican immigrants into the mainstream.

  17. Controls/CFD Interdisciplinary Research Software Generates Low-Order Linear Models for Control Design From Steady-State CFD Results

    Science.gov (United States)

    Melcher, Kevin J.

    1997-01-01

    The NASA Lewis Research Center is developing analytical methods and software tools to create a bridge between the controls and computational fluid dynamics (CFD) disciplines. Traditionally, control design engineers have used coarse nonlinear simulations to generate information for the design of new propulsion system controls. However, such traditional methods are not adequate for modeling the propulsion systems of complex, high-speed vehicles like the High Speed Civil Transport. To properly model the relevant flow physics of high-speed propulsion systems, one must use simulations based on CFD methods. Such CFD simulations have become useful tools for engineers that are designing propulsion system components. The analysis techniques and software being developed as part of this effort are an attempt to evolve CFD into a useful tool for control design as well. One major aspect of this research is the generation of linear models from steady-state CFD results. CFD simulations, often used during the design of high-speed inlets, yield high resolution operating point data. Under a NASA grant, the University of Akron has developed analytical techniques and software tools that use these data to generate linear models for control design. The resulting linear models have the same number of states as the original CFD simulation, so they are still very large and computationally cumbersome. Model reduction techniques have been successfully applied to reduce these large linear models by several orders of magnitude without significantly changing the dynamic response. The result is an accurate, easy to use, low-order linear model that takes less time to generate than those generated by traditional means. The development of methods for generating low-order linear models from steady-state CFD is most complete at the one-dimensional level, where software is available to generate models with different kinds of input and output variables. One-dimensional methods have been extended

  18. Modelling and analysis of transient state during improved coupling procedure with the grid for DFIG based wind turbine generator

    Science.gov (United States)

    Kammoun, Soulaymen; Sallem, Souhir; Ben Ali Kammoun, Mohamed

    2017-11-01

    The aim of this study is to enhance DFIG based Wind Energy Conversion Systems (WECS) dynamics during grid coupling. In this paper, a system modelling and a starting/coupling procedure for this generator to the grid are proposed. The proposed non-linear system is a variable structure system (VSS) and has two different states, before and after coupling. So, two different state models are given to the system to analyse transient stability during the coupling. The given model represents well the transient state of the machine, through which, a behaviour assessment of the generator before, during and after connection is given based on simulation results. For this, a 300 kW DFIG based wind generation system model was simulated on the Matlab/SIMULINK environment. We judge the proposed procedure to be practical, smooth and stability improved.

  19. Entanglement, Einstein Podolsky Rosen correlations and Schrodinger cat state generation by quantum-injected optical parametric amplification

    International Nuclear Information System (INIS)

    De Martini, Francesco; Sciarrino, Fabio

    2007-01-01

    We investigate the multi-photon quantum superposition state generated by the quantum-injected high-gain optical parametric amplification of a single photon. The physical configurations based on the optimal universal and on the phase-covariant quantum cloning have been adopted. The theoretical results are supported by a set of experiments leading to the generation of an average number of clones in excess of 10 3

  20. Review of Variable Generation Integration Charges

    Energy Technology Data Exchange (ETDEWEB)

    Porter, K.; Fink, S.; Buckley, M.; Rogers, J.; Hodge, B. M.

    2013-03-01

    The growth of wind and solar generation in the United States, and the expectation of continued growth of these technologies, dictates that the future power system will be operated in a somewhat different manner because of increased variability and uncertainty. A small number of balancing authorities have attempted to determine an 'integration cost' to account for these changes to their current operating practices. Some balancing authorities directly charge wind and solar generators for integration charges, whereas others add integration charges to projected costs of wind and solar in integrated resource plans or in competitive solicitations for generation. This report reviews the balancing authorities that have calculated variable generation integration charges and broadly compares and contrasts the methodologies they used to determine their specific integration charges. The report also profiles each balancing authority and how they derived wind and solar integration charges.

  1. Generation of Regionally Specific Neural Progenitor Cells (NPCs) and Neurons from Human Pluripotent Stem Cells (hPSCs).

    Science.gov (United States)

    Cutts, Josh; Brookhouser, Nicholas; Brafman, David A

    2016-01-01

    Neural progenitor cells (NPCs) derived from human pluripotent stem cells (hPSCs) are a multipotent cell population capable of long-term expansion and differentiation into a variety of neuronal subtypes. As such, NPCs have tremendous potential for disease modeling, drug screening, and regenerative medicine. Current methods for the generation of NPCs results in cell populations homogenous for pan-neural markers such as SOX1 and SOX2 but heterogeneous with respect to regional identity. In order to use NPCs and their neuronal derivatives to investigate mechanisms of neurological disorders and develop more physiologically relevant disease models, methods for generation of regionally specific NPCs and neurons are needed. Here, we describe a protocol in which exogenous manipulation of WNT signaling, through either activation or inhibition, during neural differentiation of hPSCs, promotes the formation of regionally homogenous NPCs and neuronal cultures. In addition, we provide methods to monitor and characterize the efficiency of hPSC differentiation to these regionally specific cell identities.

  2. Implementing China's national energy conservation policies at state-owned electric power generation plants

    International Nuclear Information System (INIS)

    Zhao Xiaofan; Ortolano, Leonard

    2010-01-01

    China's 11th Five-Year Guideline identified energy conservation as one of the country's fundamental policies and established a mandatory target: 20% reduction in national average energy intensity by 2010. Despite the various policies, laws, and administrative reforms to support energy conservation, China fell behind schedule for meeting its conservation targets in 2006 and 2007. Using a combination of available literature and an interview-based case study, this paper examines the implementation of energy conservation and investigates impediments to achieving China's conservation goal in the electric power generation sector. Three key impediments are detailed: (1) municipal governments' incentives to overlook conservation-related central directives primarily because of budget pressures linked to financial decentralization, (2) procedural obstacles in the form of time required to obtain project approvals for high-efficiency power generation units, and (3) financial obstacles making it difficult for power generation enterprises to raise capital for energy conservation projects. An interview-based case study of a state-owned coal-fired electric power generation company demonstrates the influence of the aforementioned obstacles. While procedural obstacles are notable, they can be managed. However, electricity pricing reforms and/or stronger subsidy programs will be needed to address the financial obstacles facing Chinese power generation companies.

  3. Solid-state pulse modulator using Marx generator for a medical linac electron-gun

    Science.gov (United States)

    Lim, Heuijin; Hyeok Jeong, Dong; Lee, Manwoo; Lee, Mujin; Yi, Jungyu; Yang, Kwangmo; Ro, Sung Chae

    2016-04-01

    A medical linac is used for the cancer treatment and consists of an accelerating column, waveguide components, a magnetron, an electron-gun, a pulse modulator, and an irradiation system. The pulse modulator based on hydrogen thyratron-switched pulse-forming network is commonly used in linac. As the improvement of the high power semiconductors in switching speed, voltage rating, and current rating, an insulated gate bipolar transistor has become the more popular device used for pulsed power systems. We propose a solid-state pulse modulator to generator high voltage by multi-stacked storage-switch stages based on the Marx generator. The advantage of our modulator comes from the use of two semiconductors to control charging and discharging of the storage capacitor at each stage and it allows to generate the pulse with various amplitudes, widths, and shapes. In addition, a gate driver for two semiconductors is designed to reduce the control channels and to protect the circuits. It is developed for providing the pulsed power to a medical linac electron-gun that requires 25 kV and 1 A as the first application. In order to improve the power efficiency and achieve the compactness modulator, a capacitor charging power supply, a Marx pulse generator, and an electron-gun heater isolated transformer are constructed and integrated. This technology is also being developed to extend the high power pulsed system with > 1 MW and also other applications such as a plasma immersed ion implantation and a micro pulse electrostatic precipitator which especially require variable pulse shape and high repetition rate > 1 kHz. The paper describes the design features and the construction of this solid-state pulse modulator. Also shown are the performance results into the linac electron-gun.

  4. Solid-state pulse modulator using Marx generator for a medical linac electron-gun

    International Nuclear Information System (INIS)

    Lim, Heuijin; Jeong, Dong Hyeok; Lee, Manwoo; Lee, Mujin; Yi, Jungyu; Yang, Kwangmo; Ro, Sung Chae

    2016-01-01

    A medical linac is used for the cancer treatment and consists of an accelerating column, waveguide components, a magnetron, an electron-gun, a pulse modulator, and an irradiation system. The pulse modulator based on hydrogen thyratron-switched pulse-forming network is commonly used in linac. As the improvement of the high power semiconductors in switching speed, voltage rating, and current rating, an insulated gate bipolar transistor has become the more popular device used for pulsed power systems. We propose a solid-state pulse modulator to generator high voltage by multi-stacked storage-switch stages based on the Marx generator. The advantage of our modulator comes from the use of two semiconductors to control charging and discharging of the storage capacitor at each stage and it allows to generate the pulse with various amplitudes, widths, and shapes. In addition, a gate driver for two semiconductors is designed to reduce the control channels and to protect the circuits. It is developed for providing the pulsed power to a medical linac electron-gun that requires 25 kV and 1 A as the first application. In order to improve the power efficiency and achieve the compactness modulator, a capacitor charging power supply, a Marx pulse generator, and an electron-gun heater isolated transformer are constructed and integrated. This technology is also being developed to extend the high power pulsed system with > 1 MW and also other applications such as a plasma immersed ion implantation and a micro pulse electrostatic precipitator which especially require variable pulse shape and high repetition rate > 1 kHz. The paper describes the design features and the construction of this solid-state pulse modulator. Also shown are the performance results into the linac electron-gun

  5. Automatic Generation of Validated Specific Epitope Sets

    Directory of Open Access Journals (Sweden)

    Sebastian Carrasco Pro

    2015-01-01

    Full Text Available Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection of T and B cells. However, the ever-growing information contained in the Immune Epitope Database (IEDB and the differences in quality and subjects studied between epitope assays make this task complicated. In this study, we develop a novel method to automatically select reference epitope sets according to a categorization system employed by the IEDB. From the sets generated, three epitope sets (EBV, mycobacteria and dengue were experimentally validated by detection of T cell reactivity ex vivo from human donors. Furthermore, a web application that will potentially be implemented in the IEDB was created to allow users the capacity to generate customized epitope sets.

  6. Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state.

    Science.gov (United States)

    Parsons, Martin Em; O'Connell, Karen; Allen, Seamus; Egan, Karl; Szklanna, Paulina B; McGuigan, Christopher; Ní Áinle, Fionnuala; Maguire, Patricia B

    2017-01-01

    Thrombin is well recognised for its role in the coagulation cascade but it also plays a role in inflammation, with enhanced thrombin generation observed in several inflammatory disorders. Although patients with multiple sclerosis (MS) have a higher incidence of thrombotic disease, thrombin generation has not been studied to date. The aim of this study was to characterise calibrated automated thrombography parameters in patients with relapsing-remitting MS (RRMS) and primary progressive MS (PPMS) in comparison to healthy controls (HCs). Calibrated automated thrombography was performed on platelet poor plasma from 15 patients with RRMS, 15 with PPMS and 19 HCs. We found that patients with RRMS generate thrombin at a significantly faster rate than the less inflammatory subtype, PPMS or HCs. In addition, the speed of thrombin generation was significantly correlated with time from clinical diagnosis in both subtypes. However, in RRMS the rate of thrombin generation was increased with increased time from clinical diagnosis, while in PPMS the rate of thrombin generation decreased with increased time from clinical diagnosis. These data likely reflect the differential active proinflammatory states in each MS subtype and provide novel mechanistic insights into the clinically relevant prothrombotic state observed in these patients.

  7. Calculation of a steam generating tube stressed state under temperature oscillations in burnout zone

    International Nuclear Information System (INIS)

    Vorob'ev, V.A.; Loshchinin, V.M.; Remizov, O.V.

    1982-01-01

    The technique for evaluating the steam generating tube stressed state under the wall temperature oscillations in the burnout zone is described. The technique is based on analytical solutions for transfer functions connecting the amplitude of surface temperature oscillation with the amplitude and frequency of heat transfer coefficient oscillation and amplitude of thermoelastic stress oscillation with that of temperature oscillation. The results of calculations according to considered technique are compared with that of the problem numerical solution. The conclusion is made that the technique under consideration may be applied for evaluation of steam generator evaporating tube lifetime [ru

  8. Creating markets for combined heat and power and clean distributed generation in New York State

    International Nuclear Information System (INIS)

    Bourgeois, Thomas G.; Hedman, Bruce; Zalcman, Fred

    2003-01-01

    Combined heat and power has been indentified as a central component in state and national energy strategy to lower power prices and reduce environmental impacts. - Combined heat and power (CHP) is the simultaneous production of electrical or mechanical power and thermal energy from in a single process. Because thermal output from the generation of electricity is captured and utilized onsite, CHP systems can achieve efficiencies from 60% to as high as 90%. In contrast generation of electric power at sites remote from the loads served often results in efficiencies of 33% or less due to losses in generation and transmission and distribution of the power to ultimate end users. A well designed CHP system is the essence of energy efficiency. It may also provide significant environmental benefits. However, the full promise of CHP for improving the efficiency and productivity of businesses and the quality of the environment is unlikely to be realized given the current market structure and regulatory environment in which CHP projects are forced to compete. This paper examines the market structure and regulatory obstacles that hinder the development of more robust markets for CHP in New York State

  9. Ultrafast optical generation of squeezed magnon states and long lifetime coherent LO phonons

    Science.gov (United States)

    Zhao, Jimin

    2005-12-01

    Ultrafast optical pulses have been used to generate, probe, and control low-energy elementary excitations in crystals. In particular, we report the first experimental demonstration of the generation of quantum squeezed states of magnons (collective spin-wave excitations) in a magnetic material, and new progress in experimental investigation of anharmonic interactions in a semiconductor. The mechanism for the magnon squeezing is two-magnon impulsive stimulated Raman scattering (ISRS). Femtosecond laser pulses have been used to coherently correlate degenerate counter-propagating magnons in the antiferromagnetic insulator MnF2. In the squeezed state, fluctuations of the magnetization of a crystallographic unit cell vary periodically in time and are reduced below that of the ground-state quantum noise. Similar experiments were also performed in another antiferromagnetic insulator, FeF2, for which the squeezing effect is one order of magnitude larger. We have also investigated the anharmonic interaction of the low-frequency E2 phonon in ZnO through ISRS. Temperature dependence of the linewidth and frequency indicates that the two-phonon up-conversion process is the dominant decay channel and isotopic disorder may be the main limit on the lifetime at low temperature. We have observed the longest lifetime of an optical phonon mode in a solid (211 ps at 5 K). And we have found that pump-probe experiments, compared with spontaneous Raman spectroscopy, have extremely high accuracy in determining the frequency of a low-lying excitation.

  10. State-specific Multi-reference Perturbation Theories with Relaxed Coefficients: Molecular Applications

    Directory of Open Access Journals (Sweden)

    Debashis Mukherjee

    2002-06-01

    Full Text Available Abstract: We present in this paper two new versions of Rayleigh-Schr¨odinger (RS and the Brillouin-Wigner (BW state-specific multi-reference perturbative theories (SSMRPT which stem from our state-specific multi-reference coupled-cluster formalism (SS-MRCC, developed with a complete active space (CAS. They are manifestly sizeextensive and are designed to avoid intruders. The combining coefficients cμ for the model functions φμ are completely relaxed and are obtained by diagonalizing an effective operator in the model space, one root of which is the target eigenvalue of interest. By invoking suitable partitioning of the hamiltonian, very convenient perturbative versions of the formalism in both the RS and the BW forms are developed for the second order energy. The unperturbed hamiltonians for these theories can be chosen to be of both Mφller-Plesset (MP and Epstein-Nesbet (EN type. However, we choose the corresponding Fock operator fμ for each model function φμ, whose diagonal elements are used to define the unperturbed hamiltonian in the MP partition. In the EN partition, we additionally include all the diagonal direct and exchange ladders. Our SS-MRPT thus utilizes a multi-partitioning strategy. Illustrative numerical applications are presented for potential energy surfaces (PES of the ground (1Σ+ and the first delta (1Δ states of CH+ which possess pronounced multi-reference character. Comparison of the results with the corresponding full CI values indicates the efficacy of our formalisms.

  11. Comparing sensitivity and specificity of screening mammography in the United States and Denmark

    DEFF Research Database (Denmark)

    Kemp Jacobsen, Katja; O'Meara, Ellen S; Key, Dustin

    2015-01-01

    Delivery of screening mammography differs substantially between the United States (US) and Denmark. We evaluated whether there are differences in screening sensitivity and specificity. We included screens from women screened at age 50-69 years during 1996-2008/2009 in the US Breast Cancer...

  12. Efficiency of defect specific maintenance od steam generator tubes: the case of ODSCC

    International Nuclear Information System (INIS)

    Cizelj, L.; Dvorsek, T.

    1996-01-01

    The outside diameter stress corrosion cracking at tube support plates became the dominating ageing mechanism in steam generators tubes made of Inconel 600. A variety of maintenance approaches were developed and implemented worldwide to deal with this mechanism. Despite different philosophical and physical backgrounds implemented, all of the applied approaches satisfy the relevant regulatory requirements. For our purpose, the maintenance approach consist of: (1) inspection of tubes, (2) accepting or rejecting the defective tube and (3) plugging of rejected tubes. The problem of selecting an optimal maintenance approach is raised in the paper. Consequently, a method comparing the efficiency of applicable maintenance approaches is proposed. The efficiency is defined by three parameters: (a) number of plugged tubes, (b) probability of steam generator tube rupture and (c) predicted accidental leak rates through the defects. An original probabilistic model is proposed to quantify the probability of tube rupture, while procedures available in literature were used to define the accidental leak rates. The numerical example considers the data from Krsko NPP (Westinghouse 632 MWe). The maintenance approaches analyzed include: (i) no repair at all, (ii) traditional defect depth (40%) based maintenance, (iii) alternate plugging criterion (bobbin coil voltage as defined by EPRI and U.S. NRC) and (iv) combined traditional and alternate approach. Advantages of the defect specific approaches (iii) and (iv) over the traditional one (defect depth) are clearly shown. A brief discussion on the optimization of safe life of steam generator is given. (author)

  13. Generation of patient-specific induced pluripotent stem cells from Leber's hereditary optic neuropathy

    Directory of Open Access Journals (Sweden)

    Huai-En Lu

    2018-04-01

    Full Text Available Leber's hereditary optic neuropathy (LHON is a maternally inherited mitochondrial disease caused by homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. In this report, we generated an induced pluripotent stem cell (iPSCs line, TVGH-iPSC-010-09, from the peripheral blood mononuclear cells of a female patient with Leber's hereditary optic neuropathy (LHON by using the Sendai-virus delivery system. The resulting iPSCs retained the disease-causing mitochondrial DNA mutation, expressed pluripotent markers and could differentiate into the three germ layers. We believe LHON patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease.

  14. On the Drive Specificity of Freudian Drives for the Generation of SEEKING Activities: The Importance of the Underestimated Imperative Motor Factor

    Directory of Open Access Journals (Sweden)

    Michael Kirsch

    2018-05-01

    Full Text Available Doubters of Freud’s theory of drives frequently mentioned that his approach is outdated and therefore cannot be useful for solving current problems in patients with mental disorders. At present, many scientists believe that affects rather than drives are of utmost importance for the emotional life and the theoretical framework of affective neuroscience, developed by Panksepp, strongly underpinned this view. Panksepp evaluated seven so-called command systems and the SEEKING system is therein of central importance. Panksepp used Pankseppian drives as inputs for the SEEKING system but noted the missing explanation of drive-specific generation of SEEKING activities in his description. Drive specificity requires dual action of the drive: the activation of a drive-specific brain area and the release of the neurotransmitter dopamine. Noticeably, as Freud claimed drive specificity too, it was here analyzed whether a Freudian drive can evoke the generation of drive-specific SEEKING activities. Special importance was addressed to the imperative motor factor in Freud’s drive theory because Panksepp’s formulations focused on neural pathways without specifying underlying neurotransmitter/endocrine factors impelling motor activity. As Panksepp claimed sleep as a Pankseppian drive, we firstly had to classified sleep as a Freudian drive by using three evaluated criteria for a Freudian drive. After that it was possible to identify the imperative motor factors of hunger, thirst, sex, and sleep. Most importantly, all of these imperative motor factors can both activate a drive-specific brain area and release dopamine from dopaminergic neurons, i.e., they can achieve the so-called drive specificity. Surprisingly, an impaired Freudian drive can alter via endocrinological pathways the concentration of the imperative motor factor of a second Freudian drive, obviously in some independence to the level of the metabolic deficit, thereby offering the possibility to

  15. Fast generating Greenberger-Horne-Zeilinger state via iterative interaction pictures

    Science.gov (United States)

    Huang, Bi-Hua; Chen, Ye-Hong; Wu, Qi-Cheng; Song, Jie; Xia, Yan

    2016-10-01

    We delve a little deeper into the construction of shortcuts to adiabatic passage for three-level systems by iterative interaction picture (multiple Schrödinger dynamics). As an application example, we use the deduced iterative based shortcuts to rapidly generate the Greenberger-Horne-Zeilinger (GHZ) state in a three-atom system with the help of quantum Zeno dynamics. Numerical simulation shows the dynamics designed by the iterative picture method is physically feasible and the shortcut scheme performs much better than that using the conventional adiabatic passage techniques. Also, the influences of various decoherence processes are discussed by numerical simulation and the results prove that the scheme is fast and robust against decoherence and operational imperfection.

  16. Hydrogen generation, distribution and combustion under severe LWR accident conditions: a state-of-technology report

    International Nuclear Information System (INIS)

    Postma, A.K.; Hilliard, R.K.

    1983-03-01

    This report reviews the current state of technology regarding hydrogen safety issues in light water reactor plants. Topics considered in this report include hydrogen generation, distribution in containment, and combustion characteristics. A companion report addresses hydrogen control. The objectives of the study were to identify the key safety issues related to hydrogen produced under severe accident conditions, to describe the state of technology for each issue, and to point out ongoing programs aimed at resolving the open issues

  17. A priori data-driven multi-clustered reservoir generation algorithm for echo state network.

    Directory of Open Access Journals (Sweden)

    Xiumin Li

    Full Text Available Echo state networks (ESNs with multi-clustered reservoir topology perform better in reservoir computing and robustness than those with random reservoir topology. However, these ESNs have a complex reservoir topology, which leads to difficulties in reservoir generation. This study focuses on the reservoir generation problem when ESN is used in environments with sufficient priori data available. Accordingly, a priori data-driven multi-cluster reservoir generation algorithm is proposed. The priori data in the proposed algorithm are used to evaluate reservoirs by calculating the precision and standard deviation of ESNs. The reservoirs are produced using the clustering method; only the reservoir with a better evaluation performance takes the place of a previous one. The final reservoir is obtained when its evaluation score reaches the preset requirement. The prediction experiment results obtained using the Mackey-Glass chaotic time series show that the proposed reservoir generation algorithm provides ESNs with extra prediction precision and increases the structure complexity of the network. Further experiments also reveal the appropriate values of the number of clusters and time window size to obtain optimal performance. The information entropy of the reservoir reaches the maximum when ESN gains the greatest precision.

  18. The impact of liberalization on the scope of efficiency improvement in electricity-generating portfolios for the United States and Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Krey, B.; Zweifel, P. [Socioeconomic Institute, Zurich (Switzerland)

    2008-09-15

    In this study, Markowitz mean-variance portfolio theory is applied to electricity-generating technologies of the United States and Switzerland. Both an investor (focused on changes in return) and a current user (focused on return in levels) view are adopted to determine efficient frontiers of electricity generation technologies in terms of expected return and risk as of 2003. Since shocks in generation costs per kWh (the inverse of returns) are correlated, Seemingly Unrelated Regression Estimation (SURE) is used to filter out the systematic components of the covariance matrix. Results suggest that risk-averse investors and risk-neutral current users in the United States are considerably closer to their efficiency frontier than their Swiss counterparts. This may be due to earlier and more thorough deregulation of electricity markets in the United States. (orig.)

  19. Generation 4 International Forum. 2009 GIF R and D outlook for generation 4 nuclear energy systems

    International Nuclear Information System (INIS)

    2009-01-01

    This document presents the state, at mid 2009, of research and development of the 6 reactor types that were selected in the framework of the GIF (Generation 4 International Forum): VHTR (Very High Temperature Reactor), SFR (Sodium-cooled Fast Reactor), SCWR (Super-Critical Water Reactor), GFR (Gas-cooled Fast Reactor), LFR (Lead-cooled reactor), and MSR (Molten Salt Reactor). Regarding each type of reactors, the state of advancement is reported for the reactor itself, its specific components and materials, its nuclear fuel, and its fuel cycle. The outlook of development and research work is also given for the next 5 years for the 6 types of reactors. (A.C.)

  20. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 3

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. This volume contains the drawings and specifications developed for the final design. This volume is divided into 5 books of which this is the third, containing drawings 47A380074 through 47A380126. A full breakdown parts listing is provided as well as a where used list.

  1. Dynamics of injection locking in a solid-state laser with intracavity second-harmonic generation

    International Nuclear Information System (INIS)

    Zolotoverkh, I I; Lariontsev, E G

    2000-01-01

    The dynamics of oscillation in a solid-state laser with intracavity second-harmonic generation under the influence of an external signal at the second-harmonic frequency injected into its cavity in the presence of feedback at the double frequency is theoretically studied. Boundaries of the regions of injection locking for three stationary laser states differing in the nonlinear phase incursion caused by radiation conversion into the second harmonic are found. Relaxation oscillations in the stationary state of injection locking are studied. It is shown that the second relaxation frequency, which is related to phase perturbations of the second harmonic and perturbations of the phase difference of waves in a nonlinear crystal, is excited in a single-mode solid-state laser in addition to the fundamental frequency of relaxation oscillations. Conditions are found under which relaxation oscillations at the second relaxation frequency are excited. (lasers)

  2. Two Schemes for Generation of Entanglement for Vibronic Collective States of Multiple Trapped Ions

    International Nuclear Information System (INIS)

    Yang Wenxing; Li Jiahua; Zheng Anshou

    2007-01-01

    We propose two schemes to prepare entanglement for the vibronic collective states of multiple trapped ions. The first scheme aims to generating multipartite entanglement for vibrational modes of trapped ions, which only requires a single laser beam tuned to the ionic carrier frequency. Our scheme works in the mediated excitation regime, in which the corresponding Rabi frequency is equal to the trap frequency. Beyond their fundamental importance, these states may be of interest for experimental studies on decoherence since the present scheme operates in a fast way. The second scheme aims to preparing the continuous variable multimode maximally Greenberger-Horne-Zeilinger state. The distinct advantage is that the operation time is only limited by the available laser intensity, not by the inherent mechanisms such as off-resonant excitations. This makes it promising to obtain entanglement of multiple coherent and squeezing states with desired amplitudes in a reasonable time.

  3. Self-assembling software generator

    Science.gov (United States)

    Bouchard, Ann M [Albuquerque, NM; Osbourn, Gordon C [Albuquerque, NM

    2011-11-25

    A technique to generate an executable task includes inspecting a task specification data structure to determine what software entities are to be generated to create the executable task, inspecting the task specification data structure to determine how the software entities will be linked after generating the software entities, inspecting the task specification data structure to determine logic to be executed by the software entities, and generating the software entities to create the executable task.

  4. Projected costs of nuclear and conventional base load electricity generation in some IAEA Member States

    International Nuclear Information System (INIS)

    1990-09-01

    The cost of nuclear and conventional electricity is one of the most important parameters for power system planning, and in particular for decisions on base load power projects. This study reviews the projected levelized electricity generation costs of the base load power generation options expected to be available in the medium term, using an agreed common economic methodology. Cost projections were obtained and evaluated for nuclear and fossil fuelled (mainly coal-fired) plants that could be commissioned in the mid- to late 1990s in 10 IAEA Member States. 27 refs, figs and tabs

  5. Use of new tandem cation/anion exchange system with clinical-scale generators provides high specific volume solutions of technetium-99m and rhenium-188

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Beets, A.L.; Mirzadeh, S.; Guhlke, S.

    1998-01-01

    In this paper we describe the first application of our simple and inexpensive post-elution tandem cation/anion exchange column system which is based on generator elution with salts of weak acids such as ammonium acetate instead of saline solution to provide very high specific volume solutions of technetium-99m and rhenium-188 from clinical-scale molybdenum-99/technetium-99m generator prepared from low specific activity (n,y) molybdenum-99, and tungsten-188/rhenium-188 generators, respectively. Initial passage of the bolus through a strong cation exchange cartridge converts the ammonium acetate to acetic acid which is essentially not ionized at the acidic pH, allowing specific subsequent amine-type (QMA SepPak TM ) anion exchange cartridge column trapping of the microscopic levels of the pertechnetate or perrhenate. Subsequent elution of the anion cartridge with a small volume ( 500 mCi/mL) from the alumina-based tungsten-188/rhenium-188 generator. (author)

  6. Environmental impacts assessment of future electricity generating plants for the State of Minas Gerais, Brazil

    International Nuclear Information System (INIS)

    Pinheiro, Ricardo Brandt; Ribeiro, Leonardo Marcio Vilela; Loures, Marcelo de Melo Gomide

    1999-01-01

    The Energy and Power Evaluation Program was used for energy planning analysis of the entire energy system of the state of Minas Gerais, Brazil. The environmental impact and resource requirements were estimated with the IMPACTS module, using results obtained from the electricity generating system expansion plan generated by WASP, together with results of marketplace energy supply and demand balances over the study period (1995-2015) computed with the BALANCE module for five different scenarios. The results for the electricity generating system show that: the air emission levels increase in all scenarios: the growth rate of the economy and energy conservation are the most important factors affecting the emissions; the land use increase significantly, the new hydroelectric power plants contributing to almost the total of this increase. (author)

  7. Specific and non-specific match effects in negative priming.

    Science.gov (United States)

    Labossière, Danielle I; Leboe-McGowan, Jason P

    2018-01-01

    The negative priming effect occurs when withholding a response to a stimulus impairs generation of subsequent responding to a same or a related stimulus. Our goal was to use the negative priming procedure to obtain insights about the memory representations generated by ignoring vs. attending/responding to a prime stimulus. Across three experiments we observed that ignoring a prime stimulus tends to generate higher identity-independent, non-specific repetition effects, owing to an overlap in the coarse perceptual form of a prime distractor and a probe target. By contrast, attended repetition effects generate predominantly identity-specific sources of facilitation. We use these findings to advocate for using laboratory phenomena to illustrate general principles that can be of practical use to non-specialists. In the case of the negative priming procedure, we propose that the procedure provides a useful means for investigating attention/memory interactions, even if the specific cause (or causes) of negative priming effects remain unresolved. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Creating Next Generation Teacher Preparation Programs to Support Implementation of the Next Generation Science Standards and Common Core State Standards in K-12 Schools: An Opportunity for the Earth and Space Sciences

    Science.gov (United States)

    Geary, E. E.; Egger, A. E.; Julin, S.; Ronca, R.; Vokos, S.; Ebert, E.; Clark-Blickenstaff, J.; Nollmeyer, G.

    2015-12-01

    A consortium of two and four year Washington State Colleges and Universities in partnership with Washington's Office of the Superintendent of Public Instruction (OSPI), the Teachers of Teachers of Science, and Teachers of Teachers of Mathematics, and other key stakeholders, is currently working to improve science and mathematics learning for all Washington State students by creating a new vision for STEM teacher preparation in Washington State aligned with the Next Generation Science Standards (NGSS) and the Common Core State Standards (CCSS) in Mathematics and Language Arts. Specific objectives include: (1) strengthening elementary and secondary STEM Teacher Preparation courses and curricula, (2) alignment of STEM teacher preparation programs across Washington State with the NGSS and CCSS, (3) development of action plans to support implementation of STEM Teacher Preparation program improvement at Higher Education Institutions (HEIs) across the state, (4) stronger collaborations between HEIs, K-12 schools, government agencies, Non-Governmental Organizations, and STEM businesses, involved in the preparation of preservice STEM teachers, (5) new teacher endorsements in Computer Science and Engineering, and (6) development of a proto-type model for rapid, adaptable, and continuous improvement of STEM teacher preparation programs. A 2015 NGSS gap analysis of teacher preparation programs across Washington State indicates relatively good alignment of courses and curricula with NGSS Disciplinary Core Ideas and Scientific practices, but minimal alignment with NGSS Engineering practices and Cross Cutting Concepts. Likewise, Computer Science and Sustainability ideas and practices are not well represented in current courses and curricula. During the coming year teams of STEM faculty, education faculty and administrators will work collaboratively to develop unique action plans for aligning and improving STEM teacher preparation courses and curricula at their institutions.

  9. Highly macroscopically degenerated single-point ground states as source of specific heat capacity anomalies in magnetic frustrated systems

    Science.gov (United States)

    Jurčišinová, E.; Jurčišin, M.

    2018-04-01

    Anomalies of the specific heat capacity are investigated in the framework of the exactly solvable antiferromagnetic spin- 1 / 2 Ising model in the external magnetic field on the geometrically frustrated tetrahedron recursive lattice. It is shown that the Schottky-type anomaly in the behavior of the specific heat capacity is related to the existence of unique highly macroscopically degenerated single-point ground states which are formed on the borders between neighboring plateau-like ground states. It is also shown that the very existence of these single-point ground states with large residual entropies predicts the appearance of another anomaly in the behavior of the specific heat capacity for low temperatures, namely, the field-induced double-peak structure, which exists, and should be observed experimentally, along with the Schottky-type anomaly in various frustrated magnetic system.

  10. Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method

    Directory of Open Access Journals (Sweden)

    Sette Alessandro

    2005-05-01

    Full Text Available Abstract Background Many processes in molecular biology involve the recognition of short sequences of nucleic-or amino acids, such as the binding of immunogenic peptides to major histocompatibility complex (MHC molecules. From experimental data, a model of the sequence specificity of these processes can be constructed, such as a sequence motif, a scoring matrix or an artificial neural network. The purpose of these models is two-fold. First, they can provide a summary of experimental results, allowing for a deeper understanding of the mechanisms involved in sequence recognition. Second, such models can be used to predict the experimental outcome for yet untested sequences. In the past we reported the development of a method to generate such models called the Stabilized Matrix Method (SMM. This method has been successfully applied to predicting peptide binding to MHC molecules, peptide transport by the transporter associated with antigen presentation (TAP and proteasomal cleavage of protein sequences. Results Herein we report the implementation of the SMM algorithm as a publicly available software package. Specific features determining the type of problems the method is most appropriate for are discussed. Advantageous features of the package are: (1 the output generated is easy to interpret, (2 input and output are both quantitative, (3 specific computational strategies to handle experimental noise are built in, (4 the algorithm is designed to effectively handle bounded experimental data, (5 experimental data from randomized peptide libraries and conventional peptides can easily be combined, and (6 it is possible to incorporate pair interactions between positions of a sequence. Conclusion Making the SMM method publicly available enables bioinformaticians and experimental biologists to easily access it, to compare its performance to other prediction methods, and to extend it to other applications.

  11. Pulse Generator

    Science.gov (United States)

    Greer, Lawrence (Inventor)

    2017-01-01

    An apparatus and a computer-implemented method for generating pulses synchronized to a rising edge of a tachometer signal from rotating machinery are disclosed. For example, in one embodiment, a pulse state machine may be configured to generate a plurality of pulses, and a period state machine may be configured to determine a period for each of the plurality of pulses.

  12. Higher-order nonclassical effects generated by multiple-photon annihilation-then-creation and creation-then-annihilation coherent states

    International Nuclear Information System (INIS)

    Yuan Hong-Chun; Xiao Jin; Xiong Chao; Zhu Xi-Fang; Xu Xue-Xiang

    2016-01-01

    We explore two observable nonclassical properties of quantum states generated by repeatedly operating annihilation-then-creation (AC) and creation-then-annihilation (CA) on the coherent state, respectively, such as higher-order sub-Poissonian statistics and higher-order squeezing-enhanced effect. The corresponding analytical expressions are derived in detail depending on m . By numerically comparing those quantum properties, it is found that these states above have very different nonclassical properties and nonclassicality is exhibited more strongly after AC operation than after CA operation. (paper)

  13. Generation and characterization of peptide-specific, MHC-restricted cytotoxic T lymphocyte (CTL) and helper T cell lines from unprimed T cells under microculture conditions.

    Science.gov (United States)

    Sambhara, S R; Upadhya, A G; Miller, R G

    1990-06-12

    We describe a microculture system for the generation of CTL and T helper cells against peptides. Tryptic digest and cyanogen bromide fragments of chicken ovalbumin and synthetic peptides of ovalbumin (323-339) and influenza virus (NP 365-380) were used to generate CTL and T helper lines from unprimed T cells. These lines were both peptide-specific and MHC-restricted. The relative ease of generating peptide-specific, MHC-restricted CTL and helper T cell lines with as few as 10(6) unprimed lymphocytes can be an efficient method of detecting potential immunogenic determinants of an antigen.

  14. Low frequency steady-state brain responses modulate large scale functional networks in a frequency-specific means.

    Science.gov (United States)

    Wang, Yi-Feng; Long, Zhiliang; Cui, Qian; Liu, Feng; Jing, Xiu-Juan; Chen, Heng; Guo, Xiao-Nan; Yan, Jin H; Chen, Hua-Fu

    2016-01-01

    Neural oscillations are essential for brain functions. Research has suggested that the frequency of neural oscillations is lower for more integrative and remote communications. In this vein, some resting-state studies have suggested that large scale networks function in the very low frequency range (frequency characteristics of brain networks because both resting-state studies and conventional frequency tagging approaches cannot simultaneously capture multiple large scale networks in controllable cognitive activities. In this preliminary study, we aimed to examine whether large scale networks can be modulated by task-induced low frequency steady-state brain responses (lfSSBRs) in a frequency-specific pattern. In a revised attention network test, the lfSSBRs were evoked in the triple network system and sensory-motor system, indicating that large scale networks can be modulated in a frequency tagging way. Furthermore, the inter- and intranetwork synchronizations as well as coherence were increased at the fundamental frequency and the first harmonic rather than at other frequency bands, indicating a frequency-specific modulation of information communication. However, there was no difference among attention conditions, indicating that lfSSBRs modulate the general attention state much stronger than distinguishing attention conditions. This study provides insights into the advantage and mechanism of lfSSBRs. More importantly, it paves a new way to investigate frequency-specific large scale brain activities. © 2015 Wiley Periodicals, Inc.

  15. Generation of Recombinant Schmallenberg Virus Nucleocapsid Protein in Yeast and Development of Virus-Specific Monoclonal Antibodies

    Directory of Open Access Journals (Sweden)

    Justas Lazutka

    2014-01-01

    Full Text Available Schmallenberg virus (SBV, discovered in continental Europe in late 2011, causes mild clinical signs in adult ruminants, including diarrhoea and reduced milk yield. However, fetal infection can lead to severe malformation in newborn offspring. To develop improved reagents for SBV serology, a high-level yeast expression system was employed to produce recombinant SBV nucleocapsid (N protein. Recombinant SBV N protein was investigated as an antigen in SBV-specific IgG enzyme immunoassay and used for generation of monoclonal antibodies (MAbs. Yeast-expressed SBV N protein was reactive with anti-SBV IgG-positive cow serum specimens collected from different farms of Lithuania. After immunization of mice with recombinant SBV N protein, four MAbs were generated. The MAbs raised against recombinant SBV N protein reacted with native viral nucleocapsids in SBV-infected BHK cells by immunofluorescence assay. The reactivity of recombinant N protein with SBV-positive cow serum specimens and the ability of the MAbs to recognize virus-infected cells confirm the antigenic similarity between yeast-expressed SBV N protein and native viral nucleocapsids. Our study demonstrates that yeast expression system is suitable for high-level production of recombinant SBV N protein and provides the first evidence on the presence of SBV-specific antibodies in cow serum specimens collected in Lithuania.

  16. Rf system specifications for a linear accelerator

    International Nuclear Information System (INIS)

    Young, A.; Eaton, L.E.

    1992-01-01

    A linear accelerator contains many systems; however, the most complex and costly is the RF system. The goal of an RF system is usually simply stated as maintaining the phase and amplitude of the RF signal within a given tolerance to accelerate the charged particle beam. An RF system that drives a linear accelerator needs a complete system specification, which should contain specifications for all the subsystems (i.e., high-power RF, low-level RF, RF generation/distribution, and automation control). This paper defines a format for the specifications of these subsystems and discusses each RF subsystem independently to provide a comprehensive understanding of the function of each subsystem. This paper concludes with an example of a specification spreadsheet allowing one to input the specifications of a subsystem. Thus, some fundamental parameters (i.e., the cost and size) of the RF system can be determined

  17. Exact analytic solutions generated from stipulated Morse and trigonometric Scarf potentials

    International Nuclear Information System (INIS)

    Saikia, N; Ahmed, S A S

    2011-01-01

    The extended transformation method has been applied to the exactly solvable stipulated Morse potential and trigonometric Scarf potential, to generate a set of exactly solvable quantum systems (QSs) in any chosen dimension. Bound state solutions of the exactly solvable potentials are given. The generated QSs are generally of Sturmian form. We also report a system case-specific regrouping technique to convert a Sturmian QS to a normal QS. A second-order application of the transformation method is given. The normalizability of the generated QSs is generally given in Sturmian form.

  18. One-Step Generation of Multiqubit Greenberger-Horne-Zeilinger States in a Driven Circuit QED System

    International Nuclear Information System (INIS)

    Huang Jinsong; Nie Wei; Wei Lianfu

    2011-01-01

    We propose an efficient scheme to generate multiqubit Greenberger-Horne-Zeilinger (GHZ) states by one-step quantum operation in a driven circuit quantum electrodynamics (QED) system. Our proposal is based on a unitary evolution exp[-iλS 2 x ], with S x being the collective spin operator in x direction and λ a controllable parameter, induced by driving the resonator. The quantum operation avoids resonator-field decay and may achieve the GHZ states with ideal success probability. The feasibility with the experimentally-demonstrated circuit QED system is also discussed. (general)

  19. Coherence-generating power of quantum dephasing processes

    Science.gov (United States)

    Styliaris, Georgios; Campos Venuti, Lorenzo; Zanardi, Paolo

    2018-03-01

    We provide a quantification of the capability of various quantum dephasing processes to generate coherence out of incoherent states. The measures defined, admitting computable expressions for any finite Hilbert-space dimension, are based on probabilistic averages and arise naturally from the viewpoint of coherence as a resource. We investigate how the capability of a dephasing process (e.g., a nonselective orthogonal measurement) to generate coherence depends on the relevant bases of the Hilbert space over which coherence is quantified and the dephasing process occurs, respectively. We extend our analysis to include those Lindblad time evolutions which, in the infinite-time limit, dephase the system under consideration and calculate their coherence-generating power as a function of time. We further identify specific families of such time evolutions that, although dephasing, have optimal (over all quantum processes) coherence-generating power for some intermediate time. Finally, we investigate the coherence-generating capability of random dephasing channels.

  20. State of the art of the virtual utility: the smart distributed generation network

    International Nuclear Information System (INIS)

    Coll-Mayor, D.; Picos, R.; Garcia-Moreno, E.

    2004-01-01

    The world of energy has lately experienced a revolution, and new rules are being defined. The climate change produced by the greenhouse gases, the inefficiency of the energy system or the lack of power supply infrastructure in most of the poor countries, the liberalization of the energy market and the development of new technologies in the field of distributed generation (DG) are the key factors of this revolution. It seems clear that the solution at the moment is the DG. The advantage of DG is the energy generation close to the demand point. It means that DG can lower costs, reduce emissions, or expand the energy options of the consumers. DG may add redundancy that increases grid security even while powering emergency lighting or other critical systems and reduces power losses in the electricity distribution. After the development of the different DG and high efficiency technologies such as co-generation and tri-generation, the next step in the DG world is the interconnection of different small distributed generation facilities which act together in a DG network as a large power plant controlled by a centralized energy management system (EMS). The main aim of the EMS is to reach the targets of low emissions and high efficiency. The EMS gives priority to renewable energy sources instead of the use of fossil fuels. This new concept of energy infrastructure is referred to as virtual utility (VU). The VU can be defined as a new model of energy infrastructure which consists of integrating different kind of distributed generation utilities in an energy (electricity and heat) generation network controlled by a central energy management system (EMS). The electricity production in the network is subordinated to the heat necessity of every user. The thermal energy is consumed on site; the electricity is generated and distributed in the entire network. The network is composed of one centralized control with the EMS and different clusters of distributed generation utilities

  1. Imaging the Where and When of Tic Generation and Resting State Networks in Adult Tourette Patients

    Directory of Open Access Journals (Sweden)

    Irene eNeuner

    2014-05-01

    Full Text Available Introduction: Tourette syndrome (TS is a neuropsychiatric disorder with the core phenomenon of tics, whose origin and temporal pattern are unclear. We investigated the When and Where of tic generation and resting state networks (RSNs via functional magnetic resonance imaging (fMRI.Methods: Tic-related activity and the underlying resting state networks in adult TS were studied within one fMRI session. Participants were instructed to lie in the scanner and to let tics occur freely. Tic onset times, as determined by video-observance were used as regressors and added to preceding time-bins of one second duration each to detect prior activation. RSN were identified by independent component analysis (ICA and correlated to disease severity by the means of dual regression.Results: Two seconds before a tic, the supplementary motor area (SMA, ventral primary motor cortex, primary sensorimotor cortex and parietal operculum exhibited activation; one second before a tic, the anterior cingulate, putamen, insula, amygdala, cerebellum and the extrastriatal-visual cortex exhibited activation; with tic-onset, the thalamus, central operculum, primary motor and somatosensory cortices exhibited activation. Analysis of resting state data resulted in 21 components including the so-called default-mode network. Network strength in those regions in SMA of two premotor ICA maps that were also active prior to tic occurrence, correlated significantly with disease severity according to the Yale Global Tic Severity Scale (YGTTS scores.Discussion: We demonstrate that the temporal pattern of tic generation follows the cortico-striato-thalamo-cortical circuit, and that cortical structures precede subcortical activation. The analysis of spontaneous fluctuations highlights the role of cortical premotor structures. Our study corroborates the notion of TS as a network disorder in which abnormal resting state network activity might contribute to the generation of tics in SMA.

  2. An Approach for Patient-Specific Multi-domain Vascular Mesh Generation Featuring Spatially Varying Wall Thickness Modeling

    OpenAIRE

    Raut, Samarth S.; Liu, Peng; Finol, Ender A.

    2015-01-01

    In this work, we present a computationally efficient image-derived volume mesh generation approach for vasculatures that implements spatially varying patient-specific wall thickness with a novel inward extrusion of the wall surface mesh. Multi-domain vascular meshes with arbitrary numbers, locations, and patterns of both iliac bifurcations and thrombi can be obtained without the need to specify features or landmark points as input. In addition, the mesh output is coordinate-frame independent ...

  3. Objective specific beam generation for image guided robotic radiosurgery

    International Nuclear Information System (INIS)

    Schlaefer, A.; Jungmann, O.; Schweikard, A.; Kilby, W.

    2007-01-01

    Robotic radiosurgery enables precise dose delivery throughout the body. Planning for robotic radiosurgery comprises of finding a suitable set of beams and beam weights. The problem can be addressed by generating a large set of candidate beams, and selection of beams with nonzero weight by mathematical programming. We propose to use different randomized beam generation methods depending on the type of lesion and the clinical objective. Results for three patient cases indicate that this can improve the plan quality. (orig.)

  4. Objective specific beam generation for image guided robotic radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Schlaefer, A.; Jungmann, O.; Schweikard, A. [Inst. for Robotics and Cognitive Systems, Univ. of Luebeck (Germany); Kilby, W. [Accuray Inc., Sunnyvale, CA (United States)

    2007-06-15

    Robotic radiosurgery enables precise dose delivery throughout the body. Planning for robotic radiosurgery comprises of finding a suitable set of beams and beam weights. The problem can be addressed by generating a large set of candidate beams, and selection of beams with nonzero weight by mathematical programming. We propose to use different randomized beam generation methods depending on the type of lesion and the clinical objective. Results for three patient cases indicate that this can improve the plan quality. (orig.)

  5. Use of a new tandem cation/anion exchange system with clinical-scale generators provides high specific volume solutions of technetium-99m and rhenium-188

    International Nuclear Information System (INIS)

    Knapp, F.R. Jr.; Beets, A.L.; Mirzadeh, S.; Guhlke, S.; Univ. of Bonn

    1998-03-01

    In this paper the authors describe the first application of a simple and inexpensive post elution tandem cation-anion exchange column system which is based on generator elution with salts of weak acids such as ammonium acetate instead of saline solution to provide very high specific volume solutions of technetium-99m and rhenium-188 from clinical scale molybdenum-99/technetium-99m generator prepared from low specific activity (n,y) molybdenum-99, and tungsten-188/rhenium-188 generators, respectively. Initial passage of the bolus through a strong cation exchange cartridge converts the ammonium acetate to acetic acid which is essentially not ionized at the acidic pH, allowing specific subsequent amine type (QMA SepPak trademark) anion exchange cartridge column trapping of the microscopic levels of the pertechnetate or perrhenate. Subsequent elution of the anion cartridge with a small volume ( 500 mCi/mL) from the alumina-based tungsten-188/rhenium-188 generator

  6. Generation of a multi-photon Greenberger-Horne-Zeilinger state with linear optical elements and photon detectors

    International Nuclear Information System (INIS)

    Zou, X B; Pahlke, K; Mathis, W

    2005-01-01

    We present a scheme to generate a multi-photon Greenberger-Horne-Zeilinger (GHZ) state by using single-photon sources, linear optical elements and photon detectors. Such a maximum entanglement has wide applications in the demonstration of quantum nonlocality and quantum information processing

  7. An Improved Abstract State Machine Based Choreography Specification and Execution Algorithm for Semantic Web Services

    Directory of Open Access Journals (Sweden)

    Shahin Mehdipour Ataee

    2018-01-01

    Full Text Available We identify significant weaknesses in the original Abstract State Machine (ASM based choreography algorithm of Web Service Modeling Ontology (WSMO, which make it impractical for use in semantic web service choreography engines. We present an improved algorithm which rectifies the weaknesses of the original algorithm, as well as a practical, fully functional choreography engine implementation in Flora-2 based on the improved algorithm. Our improvements to the choreography algorithm include (i the linking of the initial state of the ASM to the precondition of the goal, (ii the introduction of the concept of a final state in the execution of the ASM and its linking to the postcondition of the goal, and (iii modification to the execution of the ASM so that it stops when the final state condition is satisfied by the current configuration of the machine. Our choreography engine takes as input semantic web service specifications written in the Flora-2 dialect of F-logic. Furthermore, we prove the equivalence of ASMs (evolving algebras and evolving ontologies in the sense that one can simulate the other, a first in literature. Finally, we present a visual editor which facilitates the design and deployment of our F-logic based web service and goal specifications.

  8. Global and system-specific resting-state fMRI fluctuations are uncorrelated: principal component analysis reveals anti-correlated networks.

    Science.gov (United States)

    Carbonell, Felix; Bellec, Pierre; Shmuel, Amir

    2011-01-01

    The influence of the global average signal (GAS) on functional-magnetic resonance imaging (fMRI)-based resting-state functional connectivity is a matter of ongoing debate. The global average fluctuations increase the correlation between functional systems beyond the correlation that reflects their specific functional connectivity. Hence, removal of the GAS is a common practice for facilitating the observation of network-specific functional connectivity. This strategy relies on the implicit assumption of a linear-additive model according to which global fluctuations, irrespective of their origin, and network-specific fluctuations are super-positioned. However, removal of the GAS introduces spurious negative correlations between functional systems, bringing into question the validity of previous findings of negative correlations between fluctuations in the default-mode and the task-positive networks. Here we present an alternative method for estimating global fluctuations, immune to the complications associated with the GAS. Principal components analysis was applied to resting-state fMRI time-series. A global-signal effect estimator was defined as the principal component (PC) that correlated best with the GAS. The mean correlation coefficient between our proposed PC-based global effect estimator and the GAS was 0.97±0.05, demonstrating that our estimator successfully approximated the GAS. In 66 out of 68 runs, the PC that showed the highest correlation with the GAS was the first PC. Since PCs are orthogonal, our method provides an estimator of the global fluctuations, which is uncorrelated to the remaining, network-specific fluctuations. Moreover, unlike the regression of the GAS, the regression of the PC-based global effect estimator does not introduce spurious anti-correlations beyond the decrease in seed-based correlation values allowed by the assumed additive model. After regressing this PC-based estimator out of the original time-series, we observed robust anti

  9. Dynamical generation of a composite quark-lepton symmetry

    International Nuclear Information System (INIS)

    Yasue, Masaki.

    1981-05-01

    We demonstrate the possibility that a basic [SU(2)]sup(N) symmetry of N subconstituents, which describes particle and antiparticle transitions, generates at most an ''effective'' SO(2N) symmetry and at least an ''effective'' SU(N) x U(1) symmetry of composite quarks and leptons whose states are specified by the N different kinds of subconstituents. The generators of the ''effective'' symmetry, are identified by the correct algebraic properties specific to SO(2N) of composite operators constructed from the [SU(2)]sup(N)-operators acting on the composite quark-lepton states. The composite quarks and leptons are found to respect SO(4) x SO(6) or SU(2)sub(L) x U(1)sub(R) x SU(3)sub(c) x U(1)sub(B-L) according to a new selection rule, which are generated by the bilinear products of the raising and lowering operators of [SU(2)] 5 . This construction of the SO(4) x SO(6) generators allows us to uniquely define the five quantum numbers of that symmetry even at the subconstituent level. The full SO(10) generators can be also constructed; however, one needs a newly arranged [SU(2)] 5 symmetry only defined at the composite level, the generators of which turn out to be at most N body operators of the original [SU(2)] 5 . (author)

  10. Steam generator tube fitness-for-service guidelines

    International Nuclear Information System (INIS)

    Gorman, J.A.; Harris, J.E.; Lowenstein, D.B.

    1995-07-01

    The objectives of this project were to characterize defect mechanisms which could affect the integrity of steam generator tubes, to review and critique state-of-the-art Canadian and international steam generator tube fitness-for-service criteria and guidelines, and to obtain recommendations for criteria that could be used to assess fitness-for service guidelines for steam generator tubes containing defects in Canadian power plant service. Degradation mechanisms, that could affect CANDU steam generator tubes in Canada, have been characterized. The design standards and safety criteria that apply to steam generator tubing in nuclear power plant service in Canada and in Belgium, France, Japan, Spain, Sweden, and the USA have been reviewed and described. The fitness-for-service guidelines used for a variety of specific defect types in Canada and internationally have been evaluated and described in detail in order to highlight the considerations involved in developing such defect specific guidelines. Existing procedures for defect assessment and disposition have been identified, including inspection and examination practices. The approaches used in Canada and in Belgium, France, Japan, Spain, Sweden, and the USA for fitness-for-service guidelines were compared and contrasted for a variety of defect mechanisms. The strengths and weaknesses of the various approaches have been assessed. The report presents recommendations on approaches that may be adopted in the development of fitness-for-service guidelines for use in the dispositioning of steam generator tubing defects in Canada. (author). 175 refs., 2 tabs., 28 figs

  11. Medical Image Processing for Fully Integrated Subject Specific Whole Brain Mesh Generation

    Directory of Open Access Journals (Sweden)

    Chih-Yang Hsu

    2015-05-01

    Full Text Available Currently, anatomically consistent segmentation of vascular trees acquired with magnetic resonance imaging requires the use of multiple image processing steps, which, in turn, depend on manual intervention. In effect, segmentation of vascular trees from medical images is time consuming and error prone due to the tortuous geometry and weak signal in small blood vessels. To overcome errors and accelerate the image processing time, we introduce an automatic image processing pipeline for constructing subject specific computational meshes for entire cerebral vasculature, including segmentation of ancillary structures; the grey and white matter, cerebrospinal fluid space, skull, and scalp. To demonstrate the validity of the new pipeline, we segmented the entire intracranial compartment with special attention of the angioarchitecture from magnetic resonance imaging acquired for two healthy volunteers. The raw images were processed through our pipeline for automatic segmentation and mesh generation. Due to partial volume effect and finite resolution, the computational meshes intersect with each other at respective interfaces. To eliminate anatomically inconsistent overlap, we utilized morphological operations to separate the structures with a physiologically sound gap spaces. The resulting meshes exhibit anatomically correct spatial extent and relative positions without intersections. For validation, we computed critical biometrics of the angioarchitecture, the cortical surfaces, ventricular system, and cerebrospinal fluid (CSF spaces and compared against literature values. Volumina and surface areas of the computational mesh were found to be in physiological ranges. In conclusion, we present an automatic image processing pipeline to automate the segmentation of the main intracranial compartments including a subject-specific vascular trees. These computational meshes can be used in 3D immersive visualization for diagnosis, surgery planning with haptics

  12. Communication: An efficient approach to compute state-specific nuclear gradients for a generic state-averaged multi-configuration self consistent field wavefunction

    Energy Technology Data Exchange (ETDEWEB)

    Granovsky, Alexander A., E-mail: alex.granovsky@gmail.com [Firefly project, Moscow, 117593 Moscow (Russian Federation)

    2015-12-21

    We present a new, very efficient semi-numerical approach for the computation of state-specific nuclear gradients of a generic state-averaged multi-configuration self consistent field wavefunction. Our approach eliminates the costly coupled-perturbed multi-configuration Hartree-Fock step as well as the associated integral transformation stage. The details of the implementation within the Firefly quantum chemistry package are discussed and several sample applications are given. The new approach is routinely applicable to geometry optimization of molecular systems with 1000+ basis functions using a standalone multi-core workstation.

  13. Communication: An efficient approach to compute state-specific nuclear gradients for a generic state-averaged multi-configuration self consistent field wavefunction

    International Nuclear Information System (INIS)

    Granovsky, Alexander A.

    2015-01-01

    We present a new, very efficient semi-numerical approach for the computation of state-specific nuclear gradients of a generic state-averaged multi-configuration self consistent field wavefunction. Our approach eliminates the costly coupled-perturbed multi-configuration Hartree-Fock step as well as the associated integral transformation stage. The details of the implementation within the Firefly quantum chemistry package are discussed and several sample applications are given. The new approach is routinely applicable to geometry optimization of molecular systems with 1000+ basis functions using a standalone multi-core workstation

  14. Communication: An efficient approach to compute state-specific nuclear gradients for a generic state-averaged multi-configuration self consistent field wavefunction.

    Science.gov (United States)

    Granovsky, Alexander A

    2015-12-21

    We present a new, very efficient semi-numerical approach for the computation of state-specific nuclear gradients of a generic state-averaged multi-configuration self consistent field wavefunction. Our approach eliminates the costly coupled-perturbed multi-configuration Hartree-Fock step as well as the associated integral transformation stage. The details of the implementation within the Firefly quantum chemistry package are discussed and several sample applications are given. The new approach is routinely applicable to geometry optimization of molecular systems with 1000+ basis functions using a standalone multi-core workstation.

  15. A passion for gambling: a generation-specific conceptual analysis and review of gambling among older adults in Canada.

    Science.gov (United States)

    Alberghetti, Alessandra; Collins, Patricia A

    2015-06-01

    The proliferation of gambling opportunities in Canada, coupled with an aging population, has led to an increased prevalence of gambling among older adults. Encouraged by this trend, gambling industries have modified their activities to attract and market to this group. Yet, older adults are not a homogeneous group. The life experiences, values, and attitudes shared by generations make a cohort-specific analysis of gambling among older adults a worthwhile pursuit. Drawing from the Dualistic Model of Passion (Vallerand et al. in J Pers Soc Psychol 85(4):756-767, 2003), we discuss the role of passion in shaping gambling behaviours, and the implications of a harmonious or obsessive passion on the benefits and risks to two distinct generations of older adults. Based on their generational attributes, we posit that members of the Silent Generation (those born between 1925 and 1942) stand to gain more from the benefits of recreational gambling, but also stand lose more from problem gambling, than their children's generation, the Baby Boomers (those born between 1942 and 1964). Preventative strategies to assist problem gambling seniors, along with recommendations for further research, are discussed.

  16. Evidence of the 2s2p(1P) doubly excited state in the harmonic generation spectrum of helium

    International Nuclear Information System (INIS)

    Ngoko Djiokap, J. M.; Starace, Anthony F.

    2011-01-01

    By solving the two-active-electron time-dependent Schroedinger equation in an intense, ultrashort laser field, we investigate evidence of electron correlations in the high-order harmonic generation spectrum of helium. As the frequency of the driving laser pulse varies from 4.6 to 6.6 eV, the 13th, 11th, and 9th harmonics sequentially become resonant with the transition between the ground state and the isolated 2s2p( 1 P) autoionizing state of helium, which dramatically enhances these harmonics and changes their profiles. When each of the 9th and 13th harmonics are in resonance with this autoionizing state, there is also a low-order multiphoton resonance with a Rydberg state, resulting in a particularly large enhancement of these harmonics relative to neighboring harmonics. When the 11th harmonic is in resonance with the 2s2p( 1 P) autoionizing state, the 13th harmonic is simultaneously in resonance with numerous higher-energy autoionizing states, resulting in a competition between these two harmonics for intensity. These results demonstrate that even electron correlations occurring over a narrow energy interval can have a significant effect on strong-field processes such as harmonic generation.

  17. Distributed Dynamic State Estimator, Generator Parameter Estimation and Stability Monitoring Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Meliopoulos, Sakis [Georgia Inst. of Technology, Atlanta, GA (United States); Cokkinides, George [Georgia Inst. of Technology, Atlanta, GA (United States); Fardanesh, Bruce [New York Power Authority, NY (United States); Hedrington, Clinton [U.S. Virgin Islands Water and Power Authority (WAPA), St. Croix (U.S. Virgin Islands)

    2013-12-31

    This is the final report for this project that was performed in the period: October1, 2009 to June 30, 2013. In this project, a fully distributed high-fidelity dynamic state estimator (DSE) that continuously tracks the real time dynamic model of a wide area system with update rates better than 60 times per second is achieved. The proposed technology is based on GPS-synchronized measurements but also utilizes data from all available Intelligent Electronic Devices in the system (numerical relays, digital fault recorders, digital meters, etc.). The distributed state estimator provides the real time model of the system not only the voltage phasors. The proposed system provides the infrastructure for a variety of applications and two very important applications (a) a high fidelity generating unit parameters estimation and (b) an energy function based transient stability monitoring of a wide area electric power system with predictive capability. Also the dynamic distributed state estimation results are stored (the storage scheme includes data and coincidental model) enabling an automatic reconstruction and “play back” of a system wide disturbance. This approach enables complete play back capability with fidelity equal to that of real time with the advantage of “playing back” at a user selected speed. The proposed technologies were developed and tested in the lab during the first 18 months of the project and then demonstrated on two actual systems, the USVI Water and Power Administration system and the New York Power Authority’s Blenheim-Gilboa pumped hydro plant in the last 18 months of the project. The four main thrusts of this project, mentioned above, are extremely important to the industry. The DSE with the achieved update rates (more than 60 times per second) provides a superior solution to the “grid visibility” question. The generator parameter identification method fills an important and practical need of the industry. The “energy function” based

  18. Generating Culture-Specific Gestures for Virtual Agent Dialogs

    DEFF Research Database (Denmark)

    Endrass, Birgit; Damian, Ionut; Huber, Peter

    2010-01-01

    Integrating culture into the behavioral model of virtual agents has come into focus lately. When investigating verbal aspects of behavior, nonverbal behaviors are desirably added automatically, driven by the speech-act. In this paper, we present a corpus driven approach of generating gestures...

  19. Technical specifications, Vogtle Electric Generating Plant, Unit No. 1 (Docket No. 50-424): Appendix ''A'' to license No. NPF-61

    International Nuclear Information System (INIS)

    1987-01-01

    This technical specifications report presents information concerning the Vogtle Electric Generating Plant in the following areas: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  20. Thermodynamic state, specific heat, and enthalpy function of saturated UO2 vapor between 3,000 K and 5,000 K

    International Nuclear Information System (INIS)

    Karow, H.U.

    1977-02-01

    The properties have been determined by means of statistical mechanics. The discussion of the thermodynamic state includes the evaluation of the plasma state and its contribution to the caloric variables-of-state of saturated oxide fuel vapor. Because of the extremely high ion and electron density due to thermal ionization, the ionized component of the fuel vapor does no more represent a perfect kinetic plasma. At temperatures around 5,000 K, UO 2 vapor reaches the collective plasma state and becomes increasingly 'metallic'. - Moreover, the nonuniform molecular equilibrium composition of UO 2 vapor has been taken into account in calculating its caloric functions-of-state. The contribution to specific heat and enthalpy of thermally excited electronic states of the vapor molecules has been derived by means of a Rydberg orbital model of the UO 2 molecule. The resulting enthalpy functions and specific heats for saturated UO 2 vapor of equilibrium composition and that for pure UO 2 gas are compared with the enthalpy and specific heat data of gaseous UO 2 at lower temperatures known from literature. (orig./HP) [de

  1. An artificial generation of a few specific wave conditions: New simulator design and experimental performance

    International Nuclear Information System (INIS)

    Ramadan, A.; Mohamed, M.H.; Marzok, S.Y.; Montasser, O.A.; El Feky, A.; El Baz, A.R.

    2014-01-01

    In recent years, an amplified global awareness has led to a reawakening of interest in renewable energy technology. In an effort to reduce the worldwide dependence on fossil fuels, cleaner power generation methods are being sought in the field of solar, biomass, wind and wave energy. The importance of wave energy is increased in particular in some countries like UK, Portugal, Spain and Japan. A considerable progress has already been achieved in this field but the available technical designs are not adequate to develop reliable wave energy converters. Wave energy is the most available energy associated in water seas and oceans. Simultaneously, the wave energy has consisted of two types of energies: potential and kinetic energy. Therefore, many attempts have been applied to capture these energies. In the present work, a wave generator device has been designed and manufactured to simulate and generate the heaving motion of sea waves with different specification. A PC based electro-pneumatic control system was designed and implemented to individually control wave height, these heights are 3, 8, 16, 18 and 20 cm and different frequencies to generate these regular and irregular waves. - Highlights: • Wave energy is one of the most promising sources of renewable energy. • Most researchers built huge flume to simulate waves with large size and high budget. • A new simulator design for the direct and indirect wave energy is introduced. • The regular and irregular wave can be obtained for the new wave simulator. • This design is compact, flexible in terms amplitude, frequencies and high accuracy

  2. Simple and efficient generation of virus-specific T cells for adoptive therapy using anti-4-1BB antibody.

    Science.gov (United States)

    Imahashi, Nobuhiko; Nishida, Tetsuya; Goto, Tatsunori; Terakura, Seitaro; Watanabe, Keisuke; Hanajiri, Ryo; Sakemura, Reona; Imai, Misa; Kiyoi, Hitoshi; Naoe, Tomoki; Murata, Makoto

    2015-01-01

    Although recent studies of virus-specific T-cell (VST) therapy for viral infections after allogeneic hematopoietic stem cell transplantation have shown promising results, simple and less time-intensive and labor-intensive methods are required to generate VSTs for the wider application of VST therapy. We investigated the efficacy of anti-CD28 and anti-4-1BB antibodies, which can provide T cells with costimulatory signals similar in strength to those of antigen-presenting cells, in generating VSTs. When peripheral blood mononuclear cells were stimulated with viral peptides together with isotype control, anti-CD28, or anti-4-1BB antibodies, anti-4-1BB antibodies yielded the highest numbers of VSTs, which were on an average 7.9 times higher than those generated with isotype control antibody. The combination of anti-CD28 and anti-4-1BB antibodies did not result in increased numbers of VSTs compared with anti-4-1BB antibody alone. Importantly, the positive effect of anti-4-1BB antibody was observed regardless of the epitopes of the VSTs. In contrast, the capacity of dendritic cells (DCs) to generate VSTs differed considerably depending on the epitopes of the VSTs. Furthermore, the numbers of VSTs generated with DCs were at most similar to those generated with the anti-4-1BB antibody. Generation of VSTs with anti-4-1BB antibody did not result in excessive differentiation or deteriorated function of the generated VSTs compared with those generated with control antibody or DCs. In conclusion, VSTs can be generated rapidly and efficiently by simply stimulating peripheral blood mononuclear cells with viral peptide and anti-4-1BB antibody without using antigen-presenting cells. We propose using anti-4-1BB antibody as a novel strategy to generate VSTs for adoptive therapy.

  3. Inequality from Generation to Generation: The United States in Comparison

    OpenAIRE

    Corak, Miles

    2016-01-01

    To understand the degree of intergenerational mobility in the United States, and the differences between Americans and others, it is important to appreciate the workings and interaction of three fundamental institutions: the family, the market, and the state. But comparisons can also be misleading. The way in which families, labor markets, and government policy determine the life chances of children is complicated; the result of a particular history, societal values, and the nature of the pol...

  4. National profile on commercially generated low-level radioactive mixed waste

    Energy Technology Data Exchange (ETDEWEB)

    Klein, J.A.; Mrochek, J.E.; Jolley, R.L.; Osborne-Lee, I.W.; Francis, A.A.; Wright, T. [Oak Ridge National Lab., TN (United States)

    1992-12-01

    This report details the findings and conclusions drawn from a survey undertaken as part of a joint US Nuclear Regulatory Commission and US Environmental Protection Agency-sponsored project entitled ``National Profile on Commercially Generated Low-Level Radioactive Mixed Waste.`` The overall objective of the work was to compile a national profile on the volumes, characteristics, and treatability of commercially generated low-level mixed waste for 1990 by five major facility categories-academic, industrial, medical, and NRC-/Agreement State-licensed goverment facilities and nuclear utilities. Included in this report are descriptions of the methodology used to collect and collate the data, the procedures used to estimate the mixed waste generation rate for commercial facilities in the United States in 1990, and the identification of available treatment technologies to meet applicable EPA treatment standards (40 CFR Part 268) and, if possible, to render the hazardous component of specific mixed waste streams nonhazardous. The report also contains information on existing and potential commercial waste treatment facilities that may provide treatment for specific waste streams identified in the national survey. The report does not include any aspect of the Department of Energy`s (DOES) management of mixed waste and generally does not address wastes from remedial action activities.

  5. National profile on commercially generated low-level radioactive mixed waste

    International Nuclear Information System (INIS)

    Klein, J.A.; Mrochek, J.E.; Jolley, R.L.; Osborne-Lee, I.W.; Francis, A.A.; Wright, T.

    1992-12-01

    This report details the findings and conclusions drawn from a survey undertaken as part of a joint US Nuclear Regulatory Commission and US Environmental Protection Agency-sponsored project entitled ''National Profile on Commercially Generated Low-Level Radioactive Mixed Waste.'' The overall objective of the work was to compile a national profile on the volumes, characteristics, and treatability of commercially generated low-level mixed waste for 1990 by five major facility categories-academic, industrial, medical, and NRC-/Agreement State-licensed goverment facilities and nuclear utilities. Included in this report are descriptions of the methodology used to collect and collate the data, the procedures used to estimate the mixed waste generation rate for commercial facilities in the United States in 1990, and the identification of available treatment technologies to meet applicable EPA treatment standards (40 CFR Part 268) and, if possible, to render the hazardous component of specific mixed waste streams nonhazardous. The report also contains information on existing and potential commercial waste treatment facilities that may provide treatment for specific waste streams identified in the national survey. The report does not include any aspect of the Department of Energy's (DOES) management of mixed waste and generally does not address wastes from remedial action activities

  6. Public acceptance of nuclear power generation in the United States

    International Nuclear Information System (INIS)

    Liverman, J.L.; Thorne, R.D.

    1977-01-01

    Within the United States environmental awareness has spread and matured since the early 1960's. Evidence of this is found in cautious attitudes toward the installation of nuclear power reactors and other components of the nuclear fuel cycle. Hazards associated with nuclear energy technologies appear to attract a greater share of public attention than the hazards of nonnuclear counterparts. The association of nuclear power with nuclear weapons may be at the root of this concern. The explicit identification of increased incidences of cancer and genetic effects in humans as potential consequences of exposure to ionizing radiation and knowledge that radiation exposures and health consequences arising from nuclear power operations might occur many generations after operations cease also underlie this concern. Based in large part on these concerns, a number of actions have been taken in the United States to prevent and to delay installation and development of nuclear technology. These actions are reviewed and analyzed with emphasis on the 1976 California nuclear moratorium referendum and other more recent actions at state and national levels. They are compared with the status and outcome of similar actions in other nations as is possible. Additionally, ERDA's current approaches to public involvement in the decision making process is discussed, including the value of comprehensive analyses of health, environmental, and socioeconomic aspects of alternative energy sources in responding to public needs. U.S. plans for providing such analyses for all installed and developing energy technologies are presented with special reference to areas which require international cooperation for implementation. The value of international analysis and internationally accepted environmental control strategies for all energy technologies is also addressed

  7. Computed tomography landmark-based semi-automated mesh morphing and mapping techniques: generation of patient specific models of the human pelvis without segmentation.

    Science.gov (United States)

    Salo, Zoryana; Beek, Maarten; Wright, David; Whyne, Cari Marisa

    2015-04-13

    Current methods for the development of pelvic finite element (FE) models generally are based upon specimen specific computed tomography (CT) data. This approach has traditionally required segmentation of CT data sets, which is time consuming and necessitates high levels of user intervention due to the complex pelvic anatomy. The purpose of this research was to develop and assess CT landmark-based semi-automated mesh morphing and mapping techniques to aid the generation and mechanical analysis of specimen-specific FE models of the pelvis without the need for segmentation. A specimen-specific pelvic FE model (source) was created using traditional segmentation methods and morphed onto a CT scan of a different (target) pelvis using a landmark-based method. The morphed model was then refined through mesh mapping by moving the nodes to the bone boundary. A second target model was created using traditional segmentation techniques. CT intensity based material properties were assigned to the morphed/mapped model and to the traditionally segmented target models. Models were analyzed to evaluate their geometric concurrency and strain patterns. Strains generated in a double-leg stance configuration were compared to experimental strain gauge data generated from the same target cadaver pelvis. CT landmark-based morphing and mapping techniques were efficiently applied to create a geometrically multifaceted specimen-specific pelvic FE model, which was similar to the traditionally segmented target model and better replicated the experimental strain results (R(2)=0.873). This study has shown that mesh morphing and mapping represents an efficient validated approach for pelvic FE model generation without the need for segmentation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Solar thermoelectric generator

    Science.gov (United States)

    Toberer, Eric S.; Baranowski, Lauryn L.; Warren, Emily L.

    2016-05-03

    Solar thermoelectric generators (STEGs) are solid state heat engines that generate electricity from concentrated sunlight. A novel detailed balance model for STEGs is provided and applied to both state-of-the-art and idealized materials. STEGs can produce electricity by using sunlight to heat one side of a thermoelectric generator. While concentrated sunlight can be used to achieve extremely high temperatures (and thus improved generator efficiency), the solar absorber also emits a significant amount of black body radiation. This emitted light is the dominant loss mechanism in these generators. In this invention, we propose a solution to this problem that eliminates virtually all of the emitted black body radiation. This enables solar thermoelectric generators to operate at higher efficiency and achieve said efficient with lower levels of optical concentration. The solution is suitable for both single and dual axis solar thermoelectric generators.

  9. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

    Science.gov (United States)

    Tetteh, Paul W; Kretzschmar, Kai; Begthel, Harry; van den Born, Maaike; Korving, Jeroen; Morsink, Folkert; Farin, Henner; van Es, Johan H; Offerhaus, G Johan A; Clevers, Hans

    2016-10-18

    Current mouse models for colorectal cancer often differ significantly from human colon cancer, being largely restricted to the small intestine. Here, we aim to develop a colon-specific inducible mouse model that can faithfully recapitulate human colon cancer initiation and progression. Carbonic anhydrase I (Car1) is a gene expressed uniquely in colonic epithelial cells. We generated a colon-specific inducible Car1 CreER knock-in (KI) mouse with broad Cre activity in epithelial cells of the proximal colon and cecum. Deletion of the tumor suppressor gene Apc using the Car1 CreER KI caused tumor formation in the cecum but did not yield adenomas in the proximal colon. Mutation of both Apc and Kras yielded microadenomas in both the cecum and the proximal colon, which progressed to macroadenomas with significant morbidity. Aggressive carcinomas with some invasion into lymph nodes developed upon combined induction of oncogenic mutations of Apc, Kras, p53, and Smad4 Importantly, no adenomas were observed in the small intestine. Additionally, we observed tumors from differentiated Car1-expressing cells with Apc/Kras mutations, suggesting that a top-down model of intestinal tumorigenesis can occur with multiple mutations. Our results establish the Car1 CreER KI as a valuable mouse model to study colon-specific tumorigenesis and metastasis as well as cancer-cell-of-origin questions.

  10. Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(posCD25(high T cells for immunotherapy.

    Directory of Open Access Journals (Sweden)

    Jorieke H Peters

    Full Text Available BACKGROUND: Regulatory T cell (Treg based immunotherapy is a potential treatment for several immune disorders. By now, this approach proved successful in preclinical animal transplantation and auto-immunity models. In these models the success of Treg based immunotherapy crucially depends on the antigen-specificity of the infused Treg population. For the human setting, information is lacking on how to generate Treg with direct antigen-specificity ex vivo to be used for immunotherapy. METHODOLOGY/PRINCIPAL FINDINGS: Here, we demonstrate that in as little as two stimulation cycles with HLA mismatched allogeneic stimulator cells and T cell growth factors a very high degree of alloantigen-specificity was reached in magnetic bead isolated human CD4(posCD25(high Treg. Efficient increases in cell numbers were obtained. Primary allogeneic stimulation appeared a prerequisite in the generation of alloantigen-specific Treg, while secondary allogeneic or polyclonal stimulation with anti-CD3 plus anti-CD28 monoclonal antibodies enriched alloantigen-specificity and cell yield to a similar extent. CONCLUSIONS/SIGNIFICANCE: The ex vivo expansion protocol that we describe will very likely increase the success of clinical Treg-based immunotherapy, and will help to induce tolerance to selected antigens, while minimizing general immune suppression. This approach is of particular interest for recipients of HLA mismatched transplants.

  11. Quasideterministic generation of maximally entangled states of two mesoscopic atomic ensembles by adiabatic quantum feedback

    International Nuclear Information System (INIS)

    Di Lisi, Antonio; De Siena, Silvio; Illuminati, Fabrizio; Vitali, David

    2005-01-01

    We introduce an efficient, quasideterministic scheme to generate maximally entangled states of two atomic ensembles. The scheme is based on quantum nondemolition measurements of total atomic populations and on adiabatic quantum feedback conditioned by the measurements outputs. The high efficiency of the scheme is tested and confirmed numerically for ideal photodetection as well as in the presence of losses

  12. Specific strain work as a failure criterion in plane stress state

    International Nuclear Information System (INIS)

    Zuchowski, R.; Zietkowski, L.

    1985-01-01

    An experimental verification of failure criterion based on specific strain work was performed. Thin-walled cylindrical specimens were examined by loading with constant force and constant torque moment, assuming different values for particular tests, at the same time keeping stress intensity constant, and by subjecting to thermal cycling. It was found that the critical value of failure did not depend on axial-to-shearing stresses ratio, i.e., on the type of state of stress. Thereby, the validity of the analysed failure criterion in plane stress was confirmed. Besides, a simple description of damage development in plane stress was suggested. (orig./RF)

  13. Self-oscillations in cw solid-state ultrashort-pulse-generating lasers with mode locking by self-focusing

    International Nuclear Information System (INIS)

    Kalashnikov, V L; Krimer, D O; Mejid, F; Poloiko, I G; Mikhailov, V P

    1999-01-01

    Steady-state and transient regimes of ultrashort pulse generation are studied for cw solid-state lasers with mode locking by self-focusing. It is shown that the control parameter, which governs the nature of lasing, is the relationship between self-phase-modulation and the saturation intensity of an efficient shutter, induced by the Kerr self-focusing. Numerical modelling based on mapping the parameters of a quasi-soliton ultrashort pulse, considered in the aberration-free approximation, yields results in good agreement with experiments. (control of laser radiation parameters)

  14. Voice analysis as an objective state marker in bipolar disorder

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, M.; Busk, Jonas; Frost, M.

    2016-01-01

    features with automatically generated objective smartphone data on behavioral activities (for example, number of text messages and phone calls per day) and electronic self-monitored data (mood) on illness activity would increase the accuracy as a marker of affective states. Using smartphones, voice...... features, automatically generated objective smartphone data on behavioral activities and electronic self-monitored data were collected from 28 outpatients with bipolar disorder in naturalistic settings on a daily basis during a period of 12 weeks. Depressive and manic symptoms were assessed using...... to be more accurate, sensitive and specific in the classification of manic or mixed states with an area under the curve (AUC)=0.89 compared with an AUC=0.78 for the classification of depressive states. Combining voice features with automatically generated objective smartphone data on behavioral activities...

  15. A revision of the subtract-with-borrow random number generators

    Science.gov (United States)

    Sibidanov, Alexei

    2017-12-01

    The most popular and widely used subtract-with-borrow generator, also known as RANLUX, is reimplemented as a linear congruential generator using large integer arithmetic with the modulus size of 576 bits. Modern computers, as well as the specific structure of the modulus inferred from RANLUX, allow for the development of a fast modular multiplication - the core of the procedure. This was previously believed to be slow and have too high cost in terms of computing resources. Our tests show a significant gain in generation speed which is comparable with other fast, high quality random number generators. An additional feature is the fast skipping of generator states leading to a seeding scheme which guarantees the uniqueness of random number sequences. Licensing provisions: GPLv3 Programming language: C++, C, Assembler

  16. The role of high Rydberg states in the generation of negative ions in negative-ion discharges

    International Nuclear Information System (INIS)

    Hiskes, J.R.

    1995-01-01

    The generation of substantial yields of H - ions in a laser excited H 2 gas has been reported by Pinnaduwage and Christoforu. These H - yields have been attributed to (2 + 1) REMP photoexcitation processes leading to dissociative attachment of doubly-excited or superexcited states (SES), or dissociative attachment of high Rydberg product states. The new feature of these experiments is the implied large dissociative attachment rates, of order 10 -6 cm 3 sec -1 , values that are orders-of-magnitude larger than the dissociative attachment of the vibrationally excited levels of the ground electronic state. While these laser excitations are not directly applicable to a hydrogen negative-ion discharge, the implication of large dissociative attachment rates to the high Rydberg states may affect both the total negative-ion density and the interpretation of discharge performance. Within the discharge energetic electrons will collisionally excite the higher Rydberg states, and the relative contribution of the dissociative attachment of these states when compared with the dissociative attachment to the ground state vibrational levels, is the topic of this paper

  17. Generation of maximally entangled mixed states of two atoms via on-resonance asymmetric atom-cavity couplings

    International Nuclear Information System (INIS)

    Li, Shang-Bin

    2007-01-01

    A scheme for generating the maximally entangled mixed state of two atoms on-resonance asymmetrically coupled to a single mode optical cavity field is presented. The part frontier of both maximally entangled mixed states and maximal Bell violating mixed states can be approximately reached by the evolving reduced density matrix of two atoms if the ratio of coupling strengths of two atoms is appropriately controlled. It is also shown that exchange symmetry of global maximal concurrence is broken if and only if coupling strength ratio lies between (√(3)/3) and √(3) for the case of one-particle excitation and asymmetric coupling, while this partial symmetry breaking cannot be verified by detecting maximal Bell violation

  18. Evolving Distributed Generation Support Mechanisms: Case Studies from United States, Germany, United Kingdom, and Australia (Chinese translation)

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shengru [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Lowder, Travis R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Tian, Tian [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-07

    This is the Chinese translation of NREL/TP-6A20-67613. This report expands on a previous National Renewable Energy Laboratory (NREL) technical report (Lowder et al. 2015) that focused on the United States' unique approach to distributed generation photovoltaics (DGPV) support policies and business models. While the focus of that report was largely historical (i.e., detailing the policies and market developments that led to the growth of DGPV in the United States), this report looks forward, narrating recent changes to laws and regulations as well as the ongoing dialogues over how to incorporate distributed generation (DG) resources onto the electric grid. This report also broadens the scope of Lowder et al. (2015) to include additional countries and technologies. DGPV and storage are the principal technologies under consideration (owing to market readiness and deployment volumes), but the report also contemplates any generation resource that is (1) on the customer side of the meter, (2) used to, at least partly, offset a host's energy consumption, and/or (3) potentially available to provide grid support (e.g., through peak shaving and load shifting, ancillary services, and other means).

  19. Low-level radioactive waste management: federal-state cooperation or confusion

    International Nuclear Information System (INIS)

    Choi, Y.H.

    1984-01-01

    This paper describes and analyzes the legislative history of the Low-Level Radioactive Waste Policy Act of 1980 and discusses major issues and problems resulting from the implementation of the Act. Five specific issues addressed in this paper are: what radioactive waste constitutes ''low-level radioactive waste'' within the meaning of the Act; what responsibilities, if any, do the states have to dispose of federal radioactive waste; what liabilities and protections govern the disposal of waste not generated in a disposal-site state (hereafter, the ''host state''); to what standards of care should generators of low-level radioactive waste be held, and by what authority should such generators be licensed and inspected; which disposal-site activities should be considered ''disposal,'' and which activities should be considered ''management,'' within the meaning of the Act, and what authority do the states have, under the Act, to engage in each activity, respectively. The federal government and state governments must solve these problems in order to implement the Act, and thus, to establish equity among the 50 states, and the interstate regional compacts

  20. Waste minimization for commercial radioactive materials users generating low-level radioactive waste

    International Nuclear Information System (INIS)

    Fischer, D.K.; Gitt, M.; Williams, G.A.; Branch, S.; Otis, M.D.; McKenzie-Carter, M.A.; Schurman, D.L.

    1991-07-01

    The objective of this document is to provide a resource for all states and compact regions interested in promoting the minimization of low-level radioactive waste (LLW). This project was initiated by the Commonwealth of Massachusetts, and Massachusetts waste streams have been used as examples; however, the methods of analysis presented here are applicable to similar waste streams generated elsewhere. This document is a guide for states/compact regions to use in developing a system to evaluate and prioritize various waste minimization techniques in order to encourage individual radioactive materials users (LLW generators) to consider these techniques in their own independent evaluations. This review discusses the application of specific waste minimization techniques to waste streams characteristic of three categories of radioactive materials users: (1) industrial operations using radioactive materials in the manufacture of commercial products, (2) health care institutions, including hospitals and clinics, and (3) educational and research institutions. Massachusetts waste stream characterization data from key radioactive materials users in each category are used to illustrate the applicability of various minimization techniques. The utility group is not included because extensive information specific to this category of LLW generators is available in the literature

  1. Deterministic generation of Greenberger-Horne-Zeilinger and W states for three distant atoms via adiabatic passage

    International Nuclear Information System (INIS)

    Song Pei-Jun; Si Liu-Gang; Yang Xiao-Xue; Lü Xin-You

    2011-01-01

    We propose two schemes for generating Greenberger-Horne-Zeilinger and W states of three distant atoms. In the present schemes, the atoms are individually trapped in three spatially separated optical cavities coupled by two optical fibres. Performing an adiabatic passage along dark states, the population of cavities and fibres excited is negligible under certain conditions. In addition, the spontaneous decay of atoms is also efficiently suppressed based on our proposals. Furthermore, the discussion about the entanglement fidelity is given and we point out that our schemes work robustly with small fluctuations of experimental parameters. (general)

  2. Influence of steam generator surface state on corrosion and oxide formation

    International Nuclear Information System (INIS)

    Mazenc, Arnaud; Leclercq, Stephanie; Seyeux, Antoine; Galtayries, Anouk; Marcus, Philippe

    2012-09-01

    The corrosion and release of nickel-based alloy Steam Generator tubes are partly due to their surface state. Among the most important parameters influencing the corrosion, the effect of grain size and the effect of grain crystallographic orientation have been chosen to be studied. The aim of this study is to determine how these parameters have an impact on the corrosion of Steam Generator tubes. Thermal treatments (700 deg. C and 1050 deg. C) have been performed on several samples in Alloy 690 to obtain homogeneous grain sizes, varying from 25 μm to 110 μm. Two samples have been oxidised for four days in a recirculating autoclave, reproducing primary conditions. The changes of oxide composition and thickness were examined by ToF-SIMS on samples exposed to primary water conditions. The intensity profiles versus thicknesses of characteristic oxide anions, such as CrO - , NiO - or FeO - enable us to evaluate the effect of grain size and crystallographic orientation on the formation of an enriched inner chromium layer. As regards to the grain size, there was no effect on the growth, but smaller grains led to a chromium-rich oxide layer. The effect of crystallographic orientation was observed on the oxidation kinetics and the composition of oxide scales. (authors)

  3. Dynamic modification of the fragmentation of COq+ excited states generated with high-order harmonics

    International Nuclear Information System (INIS)

    Cao, W.; De, S.; Singh, K. P.; Chen, S.; Laurent, G.; Ray, D.; Ben-Itzhak, I.; Cocke, C. L.; Schoeffler, M. S.; Belkacem, A.; Osipov, T.; Rescigno, T.; Alnaser, A. S.; Bocharova, I. A.; Zherebtsov, S.; Kling, M. F.; Litvinyuk, I. V.

    2010-01-01

    The dynamic process of fragmentation of CO q+ excited states is investigated using a pump-probe approach. EUV radiation (32-48 eV) generated by high-order harmonics was used to ionize and excite CO molecules and a time-delayed infrared (IR) pulse (800 nm) was used to influence the evolution of the dissociating multichannel wave packet. Two groups of states, separable experimentally by their kinetic-energy release (KER), are populated by the EUV and lead to C + -O + fragmentation: direct double ionization of the neutral molecule and fragmentation of the cation leading to C + -O*, followed by autoionization of O*. The IR pulse was found to modify the KER of the latter group in a delay-dependent way which is explained with a model calculation.

  4. Present state of research and development of MHD power generation

    International Nuclear Information System (INIS)

    Ikeda, Shigeru

    1978-01-01

    MHD power generation can obtain electric energy directly from the heat energy of high speed plasma flow, and the power generating plant of 1 million kW can be realized by this method. When the MHD power generation method is combined before conventional thermal power generation method, the thermal efficiency can be raised to about 60% as compared with 38% in thermal power generation plants. The research and development of MHD power generation are in progress in USA and USSR. The research and development in Japan are in the second stage now after the first stage project for 10 years, and the Mark 7 generator with 100 kW electric output for 200 hr continuous operation is under construction. The MHD power generation is divided into three types according to the conductive fluids used, namely combustion type for thermal power generation, unequilibrated type and liquid metal type for nuclear power generation. The principle of MHD power generation and the constitution of the plant are explained. In Japan, the Mark 2 generator generated 1,180 kW for 1 min in 1971, and the Mark 3 generator generated 1.9 kW continuously for 110 hr in 1967. The MHD generator with superconducting magnet succeeded in 1969 to generate 25 kW for 6 min. The second stage project aimes at collecting design data and obtaining operational experience for the construction of 10 MW class pilot plant, and the Mark 7 and 8 generators are planned. (Kako, I.)

  5. On grey levels in random CAPTCHA generation

    Science.gov (United States)

    Newton, Fraser; Kouritzin, Michael A.

    2011-06-01

    A CAPTCHA is an automatically generated test designed to distinguish between humans and computer programs; specifically, they are designed to be easy for humans but difficult for computer programs to pass in order to prevent the abuse of resources by automated bots. They are commonly seen guarding webmail registration forms, online auction sites, and preventing brute force attacks on passwords. In the following, we address the question: How does adding a grey level to random CAPTCHA generation affect the utility of the CAPTCHA? We treat the problem of generating the random CAPTCHA as one of random field simulation: An initial state of background noise is evolved over time using Gibbs sampling and an efficient algorithm for generating correlated random variables. This approach has already been found to yield highly-readable yet difficult-to-crack CAPTCHAs. We detail how the requisite parameters for introducing grey levels are estimated and how we generate the random CAPTCHA. The resulting CAPTCHA will be evaluated in terms of human readability as well as its resistance to automated attacks in the forms of character segmentation and optical character recognition.

  6. Screening for SNPs with Allele-Specific Methylation based on Next-Generation Sequencing Data.

    Science.gov (United States)

    Hu, Bo; Ji, Yuan; Xu, Yaomin; Ting, Angela H

    2013-05-01

    Allele-specific methylation (ASM) has long been studied but mainly documented in the context of genomic imprinting and X chromosome inactivation. Taking advantage of the next-generation sequencing technology, we conduct a high-throughput sequencing experiment with four prostate cell lines to survey the whole genome and identify single nucleotide polymorphisms (SNPs) with ASM. A Bayesian approach is proposed to model the counts of short reads for each SNP conditional on its genotypes of multiple subjects, leading to a posterior probability of ASM. We flag SNPs with high posterior probabilities of ASM by accounting for multiple comparisons based on posterior false discovery rates. Applying the Bayesian approach to the in-house prostate cell line data, we identify 269 SNPs as candidates of ASM. A simulation study is carried out to demonstrate the quantitative performance of the proposed approach.

  7. Generation and Characterization of Inhibitory Antibodies Specific to Guinea Pig CXCR1 and CXCR2.

    Science.gov (United States)

    Tanaka, Kento; Yoshimura, Chigusa; Shiina, Tetsuo; Terauchi, Tomoko; Yoshitomi, Tomomi; Hirahara, Kazuki

    2017-04-01

    CXCR1 and CXCR2 are chemokine receptors that have different selectivity of chemokine ligands, but the distinct role of each receptor is not clearly understood. This is due to the absence of specific inhibitors in guinea pigs, which are the appropriate species for investigation of CXCR1 and CXCR2 because of their functional similarity to humans. In this study, we generated and evaluated monoclonal antibodies that specifically bound to guinea pig CXCR1 (gpCXCR1) and guinea pig CXCR2 (gpCXCR2) for acquisition of specific inhibitors. To assess the activity of antibodies, we established CHO-K1 cells stably expressing either gpCXCR1 or gpCXCR2 (CHO/gpCXCR1 or CHO/gpCXCR2). CHO/gpCXCR1 showed migration in response to guinea pig interleukin (IL)-8, and CHO/gpCXCR2 showed migration in response to both guinea pig IL-8 and guinea pig growth-regulated oncogene α. The receptor selectivities of the chemokines of guinea pigs were the same as the human orthologs. The inhibitory activities of the anti-gpCXCR1 and anti-gpCXCR2 monoclonal antibodies on cell migration were observed in a concentration-dependent manner. In conclusion, we successfully obtained inhibitory antibodies specific to gpCXCR1 and gpCXCR2. These inhibitory antibodies will be useful to clarify the physiological roles of CXCR1 and CXCR2 in guinea pigs.

  8. Generation of new spatial and temporal coherent states using VECSEL technology: VORTEX, high order Laguerre-Gauss mode, continuum source

    Science.gov (United States)

    Sellahi, Mohamed; Seghilani, Mohamed Seghir; Sagnes, Isabelle; Beaudoin, Gregoire; Lafosse, Xavier; Legratiet, Luc; Lalanne, Philippe; Myara, Mikhal; Garnache, Arnaud

    2017-11-01

    Since years, the VeCSEL concept is pointed out as a technology of choice for beyond-state-of-the-art laser light sources. The targeted coherent state in CW is typically the common gaussian TEM00, single frequency, linearly polarized lightstate. In this work, we take advantage of the VeCSEL technology for the generation of other kinds of coherent states, thanks to the insertion of intracavity functions, such as low-loss intensity and phase filters integrated on a semiconductor chip. This technological development permitted to demonstrate very pure high-order Laguerre-Gauss mode, both degenerate and non-degenerate(vortex)modes, preserving the coherence properties of usual TEM00 VeCSELs. This technology paves the way for the generation of other coherences (Bessel beams) or new functionnalities (wavelength filtering, etc.). We also explore new time domain coherence : owing to a high gain semiconductor chip design and the insertion of intracavity AOM, we demonstrated the first Frequecy-Shifted-Feedback VeCSEL, with a broadband coherence state as wide as 300 GHz.

  9. Do state renewable portfolio standards promote in-state renewable generation

    International Nuclear Information System (INIS)

    Yin, Haitao; Powers, Nicholas

    2010-01-01

    Several US states have passed renewable portfolio standard (RPS) policies in order to encourage investment in renewable energy technologies. Existing research on their effectiveness has either employed a cross-sectional approach or has ignored heterogeneity among RPS policies. In this paper, we introduce a new measure for the stringency of an RPS that explicitly accounts for some RPS design features that may have a significant impact on the strength of an RPS. We also investigate the impacts of renewable portfolio standards on in-state renewable electricity development using panel data and our new measure of RPS stringency, and compare the results with those when alternative measures are used. Using our new measure, the results suggest that RPS policies have had a significant and positive effect on in-state renewable energy development, a finding which is masked when design differences among RPS policies are ignored. We also find that another important design feature - allowing 'free trade' of REC's - can significantly weaken the impact of an RPS. These results should prove instructive to policy makers, whether considering the development of a federal-level RPS or the development or redesign of a state-level RPS. (author)

  10. Racial and ethnic disparities in human papillomavirus-associated cancer burden with first-generation and second-generation human papillomavirus vaccines.

    Science.gov (United States)

    Burger, Emily A; Lee, Kyueun; Saraiya, Mona; Thompson, Trevor D; Chesson, Harrell W; Markowitz, Lauri E; Kim, Jane J

    2016-07-01

    In the United States, the burden of human papillomavirus (HPV)-associated cancers varies by racial/ethnic group. HPV vaccination may provide opportunities for primary prevention of these cancers. Herein, the authors projected changes in HPV-associated cancer burden among racial/ethnic groups under various coverage assumptions with the available first-generation and second-generation HPV vaccines to evaluate changes in racial/ethnic disparities. Cancer-specific mathematical models simulated the burden of 6 HPV-associated cancers. Model parameters, informed using national registries and epidemiological studies, reflected sex-specific, age-specific, and racial/ethnic-specific heterogeneities in HPV type distribution, cancer incidence, stage of disease at detection, and mortality. Model outcomes included the cumulative lifetime risks of developing and dying of 6 HPV-associated cancers. The level of racial/ethnic disparities was evaluated under each alternative HPV vaccine scenario using several metrics of social group disparity. HPV vaccination is expected to reduce the risks of developing and dying of HPV-associated cancers in all racial/ethnic groups as well as reduce the absolute degree of disparities. However, alternative metrics suggested that relative disparities would persist and in some scenarios worsen. For example, when assuming high uptake with the second-generation HPV vaccine, the lifetime risk of dying of an HPV-associated cancer for males decreased by approximately 60%, yet the relative disparity increased from 3.0 to 3.9. HPV vaccines are expected to reduce the overall burden of HPV-associated cancers for all racial/ethnic groups and to reduce the absolute disparity gap. However, even with the second-generation vaccine, relative disparities will likely still exist and may widen if the underlying causes of these disparities remain unaddressed. Cancer 2016;122:2057-66. © 2016 American Cancer Society. © 2016 American Cancer Society.

  11. Evaluation of chloride-ion-specific electrodes as in situ chemical sensors for monitoring total chloride concentration in aqueous solutions generated during the recovery of plutonium from molten salts used in plutonium electrorefining operations

    International Nuclear Information System (INIS)

    Smith, W.H.

    1992-10-01

    Two commercially available chloride-ion-specific electrodes (CLISEs), a solid-state type and a membrane type, were evaluated as potential in situ chemical sensors for determining total chloride ion concentration in mixed sodium chloride/potassium chloride/hydrochloric acid solutions generated during the recovery of plutonium from molten salts used in plutonium electrorefining operations. Because the response of the solid-state CLISE was closer than was the response of the membrane-type CLISE to the theoretical response predicted by the Nernst equation, the solid-state CLISE was selected for further evaluation. A detailed investigation of the characteristics of the chloride system and the corresponding CLISE response to concentration changes suggested four methods by which the CLISE could be used either as a direct, in situ sensor or as an indirect sensor through which an analysis could be performed on-line with a sample extracted from the process solution

  12. Properties of Griffin-Hill-Wheeler spaces - 2. one-parameters and two-conjugate parameter families of generator states

    International Nuclear Information System (INIS)

    Passos, E.J.V. de; Toledo Piza, A.F.R. de.

    The properties of the subspaces of the many-body Hilbert space which are associated with the use of the Generator Coordinate Method (GCM) in connection with one parameter, and with two-conjugate parameter families of generator states are examined in detail. It is shown that natural orthonormal base vectors in each case are immediately related to Peierls-Voccoz and Peierls-Thouless projections respectively. Through the formal consideration of a canonical transformation to collective, P and Q, and intrinsic degrees of freedom, the properties of the GCM subspaces with respect to the kinematical separation of these degrees of freedom are discussed in detail. An application is made, using the ideas developed in this paper, a) to translation; b) to illustrate the qualitative understanting of the content of existing GCM calculations of giant ressonances in light nuclei and c) to the definition of appropriate asymptotic states in current GCM descriptions of scattering [pt

  13. Using domain specific languages to improve the development of a power control unit

    NARCIS (Netherlands)

    Schuts, M.; Hooman, J.

    2015-01-01

    To improve the design of a power control unit at Philips, two Domain Specific Languages (DSLs) have been used. The first DSL provides a concise and readable notation for the essential state transitions. It is used to generate both configuration files and analysis models. In addition, we also

  14. Sociocultural Constraints: The Relation between Generations in the United States, Parental Education, Income, Hispanic Origin and the Financial Aid Packages of Hispanic Undergraduate Students

    Science.gov (United States)

    Del Razo, Parvati Heliana

    2012-01-01

    The purpose of this study was to find out if the demographic variables of country of origin, generation in the United States (immigration status), income and parental education had an impact on the financial aid packages of Hispanic undergraduate students. This dissertation asked: What is the relation between generation in the United States,…

  15. Dendritic cells transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes against ovarian cancer in vitro

    International Nuclear Information System (INIS)

    Sun, Li; Kong, Beihua; Sheng, Xiugui; Sheu, Jim Jinn-Chyuan; Shih, Ie-Ming

    2010-01-01

    Recently, some studies have indicated that Rsf-1/HBXAP plays a role in chromatin remodeling and transcriptional regulation that may contribute to tumorigenesis in ovarian cancer. The present study demonstrates that using dendritic cells (DCs) from human cord blood CD34 + cells transduced with Rsf-1/HBXAP DNA plasmids by nucleofection generate specific cytotoxic T lymphocytes (CTL) against ovarian cancer in vitro. After transfection, DCs were analyzed for Rsf-1/HBXAP mRNA expression by RT-PCR and protein expression by Western blot. Then the DC phenotypes, T-cell stimulatory capacity, endocytic activity and migration capacity were explored by flow cytometry analysis, allogeneic mixed lymphocyte reaction, endocytosis and transwell chemotaxis assay, respectively. After transfection, Rsf-1/HBXAP expression was detected at mRNA and protein levels. Allogeneic T-cell proliferation induced by transfected DCs was obviously higher than non-transfected DCs, but the endocytosis capacity and migratory ability were not different. Rsf-1/HBXAP gene-transduced DCs could induce antigen-specific CTL and generate a very potent cytotoxicity to OVCAR3 cells. These data suggest that Rsf-1/HBXAP gene-transduced DCs may be a potential adjuvant immunotherapy for ovarian cancer in clinical applications.

  16. Charge Carrier Generation Followed by Triplet State Formation, Annihilation, and Carrier Recreation in PBDTTT-C:PC 60 BM Photovoltaic Blends

    KAUST Repository

    Gehrig, Dominik W.

    2015-05-22

    Triplet state formation after photoexcitation of low-bandgap polymer:fullerene blends has recently been demonstrated, however, the precise mechanism and its impact on solar cell performance is still under debate. Here, we study exciton dissociation, charge carrier generation and triplet state formation in low-bandgap polymer PBDTTT-C:PC60BM bulk heterojunction photovoltaic blends by a combination of fs-µs broadband Vis-NIR transient absorption (TA) pump-probe spectroscopy and multivariate curve resolution (MCR) data analysis. We found sub-ps exciton dissociation and charge generation followed by sub-ns triplet state creation. The carrier dynamics and triplet state dynamics exhibited a very pronounced intensity dependence indicating non-geminate recombination of free carriers is the origin of triplet formation in these blends. Triplets were found to be the dominant state present on the nanosecond timescale. Surprisingly, the carrier population increased again on the ns-µs timescale. We attribute this to triplet-triplet annihilation and the formation of higher energy excited states that subsequently underwent charge transfer. This unique dip and recovery of the charge population is a clear indication that triplets are formed by non-geminate recombination, as such a kinetic is incompatible with a monomolecular triplet state formation process.

  17. Charge Carrier Generation Followed by Triplet State Formation, Annihilation, and Carrier Recreation in PBDTTT-C:PC 60 BM Photovoltaic Blends

    KAUST Repository

    Gehrig, Dominik W.; Howard, Ian A.; Laquai, Fré dé ric

    2015-01-01

    Triplet state formation after photoexcitation of low-bandgap polymer:fullerene blends has recently been demonstrated, however, the precise mechanism and its impact on solar cell performance is still under debate. Here, we study exciton dissociation, charge carrier generation and triplet state formation in low-bandgap polymer PBDTTT-C:PC60BM bulk heterojunction photovoltaic blends by a combination of fs-µs broadband Vis-NIR transient absorption (TA) pump-probe spectroscopy and multivariate curve resolution (MCR) data analysis. We found sub-ps exciton dissociation and charge generation followed by sub-ns triplet state creation. The carrier dynamics and triplet state dynamics exhibited a very pronounced intensity dependence indicating non-geminate recombination of free carriers is the origin of triplet formation in these blends. Triplets were found to be the dominant state present on the nanosecond timescale. Surprisingly, the carrier population increased again on the ns-µs timescale. We attribute this to triplet-triplet annihilation and the formation of higher energy excited states that subsequently underwent charge transfer. This unique dip and recovery of the charge population is a clear indication that triplets are formed by non-geminate recombination, as such a kinetic is incompatible with a monomolecular triplet state formation process.

  18. Four Generations of Maintenance Resource Management Programs in the United States: An Analysis of the Past, Present, and Future

    Science.gov (United States)

    Taylor, James C.; Patankar, Manoj S.

    2001-01-01

    This paper analyzes four generations of Maintenance Resource Management (MRM) programs implemented by aviation maintenance organizations in the United States. Data collected from over ten years of survey research and field observations are used for this analysis; they are presented in a case-study format. The first three generations of MRM programs were episodic efforts to increase safety through teamwork, focus group discussions, and awareness courses, respectively. Now, the fourth generation programs, characterized by a commitment to long-term communication and behavioral changes in maintenance, are set to build on those earlier generations, toward a culture of mutual trust between mechanics, their managers, and regulators.

  19. Quantumness-generating capability of quantum dynamics

    Science.gov (United States)

    Li, Nan; Luo, Shunlong; Mao, Yuanyuan

    2018-04-01

    We study quantumness-generating capability of quantum dynamics, where quantumness refers to the noncommutativity between the initial state and the evolving state. In terms of the commutator of the square roots of the initial state and the evolving state, we define a measure to quantify the quantumness-generating capability of quantum dynamics with respect to initial states. Quantumness-generating capability is absent in classical dynamics and hence is a fundamental characteristic of quantum dynamics. For qubit systems, we present an analytical form for this measure, by virtue of which we analyze several prototypical dynamics such as unitary dynamics, phase damping dynamics, amplitude damping dynamics, and random unitary dynamics (Pauli channels). Necessary and sufficient conditions for the monotonicity of quantumness-generating capability are also identified. Finally, we compare these conditions for the monotonicity of quantumness-generating capability with those for various Markovianities and illustrate that quantumness-generating capability and quantum Markovianity are closely related, although they capture different aspects of quantum dynamics.

  20. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    Science.gov (United States)

    2013-01-01

    Background Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. Methods We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Results Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the

  1. The importance of lake-specific characteristics for water quality across the continental United States.

    Science.gov (United States)

    Read, Emily K; Patil, Vijay P; Oliver, Samantha K; Hetherington, Amy L; Brentrup, Jennifer A; Zwart, Jacob A; Winters, Kirsten M; Corman, Jessica R; Nodine, Emily R; Woolway, R Iestyn; Dugan, Hilary A; Jaimes, Aline; Santoso, Arianto B; Hong, Grace S; Winslow, Luke A; Hanson, Paul C; Weathers, Kathleen C

    2015-06-01

    Lake water quality is affected by local and regional drivers, including lake physical characteristics, hydrology, landscape position, land cover, land use, geology, and climate. Here, we demonstrate the utility of hypothesis testing within the landscape limnology framework using a random forest algorithm on a national-scale, spatially explicit data set, the United States Environmental Protection Agency's 2007 National Lakes Assessment. For 1026 lakes, we tested the relative importance of water quality drivers across spatial scales, the importance of hydrologic connectivity in mediating water quality drivers, and how the importance of both spatial scale and connectivity differ across response variables for five important in-lake water quality metrics (total phosphorus, total nitrogen, dissolved organic carbon, turbidity, and conductivity). By modeling the effect of water quality predictors at different spatial scales, we found that lake-specific characteristics (e.g., depth, sediment area-to-volume ratio) were important for explaining water quality (54-60% variance explained), and that regionalization schemes were much less effective than lake specific metrics (28-39% variance explained). Basin-scale land use and land cover explained between 45-62% of variance, and forest cover and agricultural land uses were among the most important basin-scale predictors. Water quality drivers did not operate independently; in some cases, hydrologic connectivity (the presence of upstream surface water features) mediated the effect of regional-scale drivers. For example, for water quality in lakes with upstream lakes, regional classification schemes were much less effective predictors than lake-specific variables, in contrast to lakes with no upstream lakes or with no surface inflows. At the scale of the continental United States, conductivity was explained by drivers operating at larger spatial scales than for other water quality responses. The current regulatory practice of using

  2. Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females.

    Science.gov (United States)

    Garner, Sarah Rose C; Castellanos, Monica C; Baillie, Katherine E; Lian, Tianshun; Allan, Douglas W

    2018-01-08

    Female-specific Ilp7 neuropeptide-expressing motoneurons (FS-Ilp7 motoneurons) are required in Drosophila for oviduct function in egg laying. Here, we uncover cellular and genetic mechanisms underlying their female-specific generation. We demonstrate that programmed cell death (PCD) eliminates FS-Ilp7 motoneurons in males, and that this requires male-specific splicing of the sex-determination gene fruitless ( fru ) into the Fru MC isoform. However, in females, fru alleles that only generate Fru M isoforms failed to kill FS-Ilp7 motoneurons. This blockade of Fru M -dependent PCD was not attributable to doublesex gene function but to a non-canonical role for transformer ( tra ), a gene encoding the RNA splicing activator that regulates female-specific splicing of fru and dsx transcripts. In both sexes, we show that Tra prevents PCD even when the Fru M isoform is expressed. In addition, we found that Fru MC eliminated FS-Ilp7 motoneurons in both sexes, but only when Tra was absent. Thus, Fru MC -dependent PCD eliminates female-specific neurons in males, and Tra plays a double-assurance function in females to establish and reinforce the decision to generate female-specific neurons. © 2018. Published by The Company of Biologists Ltd.

  3. Second-generation migrants: Europe and the United States

    NARCIS (Netherlands)

    Crul, M.R.J.; Schneider, J.; Ness, I.; Bellwood, P.

    2013-01-01

    The public debate about the second generation in Europe has taken a dramatic shift in the last five years. The riots in the banlieues in France, involving mostly Algerian and Moroccan second-generation youth, pitched the cherished republican model into deep crisis. In the Netherlands, arguments

  4. Advanced generation anti-prostate specific membrane antigen designer T cells for prostate cancer immunotherapy.

    Science.gov (United States)

    Ma, Qiangzhong; Gomes, Erica M; Lo, Agnes Shuk-Yee; Junghans, Richard P

    2014-02-01

    Adoptive immunotherapy by infusion of designer T cells (dTc) engineered with chimeric antigen receptors (CARs) for tumoricidal activity represents a potentially highly specific modality for the treatment of cancer. In this study, 2nd generation (gen) anti-prostate specific membrane antigen (PSMA) dTc were developed for improving the efficacy of previously developed 1st gen dTc for prostate cancer immunotherapy. The 1st gen dTc are modified with chimeric immunoglobulin-T cell receptor (IgTCR) while the 2nd gen dTc are engineered with an immunoglobulin-CD28-T cell receptor (IgCD28TCR), which incorporates a CD28 costimulatory signal for optimal T cell activation. A 2nd gen anti-PSMA IgCD28TCR CAR was constructed by inserting the CD28 signal domain into the 1st gen CAR. 1st and 2nd gen anti-PSMA dTc were created by transducing human T cells with anti-PSMA CARs and their antitumor efficacy was compared for specific activation on PSMA-expressing tumor contact, cytotoxicity against PSMA-expressing tumor cells in vitro, and suppression of tumor growth in an animal model. The 2nd gen dTc can be optimally activated to secrete larger amounts of cytokines such as IL2 and IFNγ than 1st gen and to proliferate more vigorously on PSMA-expressing tumor contact. More importantly, the 2nd gen dTc preserve the PSMA-specific cytotoxicity in vitro and suppress tumor growth in animal models with significant higher potency. Our results demonstrate that 2nd gen anti-PSMA designer T cells exhibit superior antitumor functions versus 1st gen, providing a rationale for advancing this improved agent toward clinical application in prostate cancer immunotherapy. © 2013 Wiley Periodicals, Inc.

  5. Design of the real time systems using temporal logic specifications: a case study

    Directory of Open Access Journals (Sweden)

    A. Ursu

    1996-07-01

    Full Text Available An implementation method for real time systems is proposed in this article. The implementation starts with the design of the functional specifications of the systems behaviour. The functional specifications are introduced as a set of rules describing the partial time ordering of the actions performed by the system. These rules are then written in terms of temporal logic formulae. The temporal logic formulae are checked using Z.Manna-P.Wolper satisfiability analysis procedure [1]. It is known that this procedure generates a state-graph which can be regarded as a state- based automaton of the system. The sate-based automaton is used then to generate the dual (inverted automaton of the system. The dual automaton is called action-based automaton and can be created using the procedure proposed by authors in [4,5]. Using the action-based automaton of the system the design method introduced in [5,6] is applied to implement the system driver in a systematic manner which can be computerised. The method proposed in this paper is an efficient complementation and generalisation of the results [4,5,6] mentioned above. The method is used for a case study. An elevator control system is designed using the proposed method. The design is carried out in a systematic manner which includes: a design of functional specifications, b design of temporal logic specifications, c satisfiability analysis of temporal logic specifications, d design of the state-based automaton of the specifications, e design of the action-based automaton of the system, f design of the transition activation conditions, g design of the action activation conditions, h design of the functional model of the elevator control system, i implementation of the elevator's actions, j design of the elevator control system driver.

  6. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State.

    Science.gov (United States)

    Li, Xiang; Liu, Defang; Ma, Yantao; Du, Xiaomin; Jing, Junzhan; Wang, Lipeng; Xie, Bingqing; Sun, Da; Sun, Shaoqiang; Jin, Xueqin; Zhang, Xu; Zhao, Ting; Guan, Jingyang; Yi, Zexuan; Lai, Weifeng; Zheng, Ping; Huang, Zhuo; Chang, Yanzhong; Chai, Zhen; Xu, Jun; Deng, Hongkui

    2017-08-03

    Direct lineage reprogramming, including with small molecules, has emerged as a promising approach for generating desired cell types. We recently found that during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts, cells pass through an extra-embryonic endoderm (XEN)-like state. Here, we show that these chemically induced XEN-like cells can also be induced to directly reprogram into functional neurons, bypassing the pluripotent state. The induced neurons possess neuron-specific expression profiles, form functional synapses in culture, and further mature after transplantation into the adult mouse brain. Using similar principles, we were also able to induce hepatocyte-like cells from the XEN-like cells. Cells in the induced XEN-like state were readily expandable over at least 20 passages and retained genome stability and lineage specification potential. Our study therefore establishes a multifunctional route for chemical lineage reprogramming and may provide a platform for generating a diverse range of cell types via application of this expandable XEN-like state. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters

    NARCIS (Netherlands)

    Wieczorek, Sebastian; Krause, Eberhard; Hackbarth, Steffen; Roeder, Beate; Hirsch, Anna K. H.; Boerner, Hans G.

    2013-01-01

    A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble

  8. Conventional, hybrid, plug-in hybrid or electric vehicles? State-based comparative carbon and energy footprint analysis in the United States

    International Nuclear Information System (INIS)

    Onat, Nuri Cihat; Kucukvar, Murat; Tatari, Omer

    2015-01-01

    Highlights: • Driving patterns and electricity generation mix influence vehicle preferences. • EVs are found to be least carbon-intensive vehicle option in 24 states. • HEVs are found to be the most energy-efficient option in 45 states. • EVs across the board are unfavorable in the marginal electricity mix scenario. • Use of renewable energy to power EVs/PHEVs is crucial. - Abstract: Electric vehicles (EVs), plug-in hybrid electric vehicles (PHEVs), and hybrid electric vehicles (HEVs) are often considered as better options in terms of greenhouse gas emissions and energy consumption compared to internal combustion vehicles. However, making any decision among these vehicle options is not a straightforward process due to temporal and spatial variations, such as the sources of the electricity used and regional driving patterns. In this study, we compared these vehicle options across 50 states, taking into account state-specific average and marginal electricity generation mixes, regional driving patterns, and vehicle and battery manufacturing impacts. Furthermore, a policy scenario proposing the widespread use of solar energy to charge EVs and PHEVs is evaluated. Based on the average electricity generation mix scenario, EVs are found to be least carbon-intensive vehicle option in 24 states, while HEVs are found to be the most energy-efficient option in 45 states. In the marginal electricity mix scenario, widespread adoption of EVs is found to be an unwise strategy given the existing and near-future marginal electricity generation mix. On the other hand, EVs can be superior to other alternatives in terms of energy-consumption, if the required energy to generate 1 kW h of electricity is below 1.25 kW h

  9. EOSCUBE: A Constraint Database System for High-Level Specification and Efficient Generation of EOSDIS Products. Phase 1; Proof-of-Concept

    Science.gov (United States)

    Brodsky, Alexander; Segal, Victor E.

    1999-01-01

    The EOSCUBE constraint database system is designed to be a software productivity tool for high-level specification and efficient generation of EOSDIS and other scientific products. These products are typically derived from large volumes of multidimensional data which are collected via a range of scientific instruments.

  10. Generation of species-specific DNA probes for Leishmania aethiopica

    NARCIS (Netherlands)

    Laskay, T.; Kiessling, R.; Rinke deWit, T. F.; Wirth, D. F.

    1991-01-01

    We report here the cloning of kinetoplast DNA (kDNA) sequences from Leishmania aethiopica in order to develop a specific and sensitive method for the identification of the parasite. Analysis of the cloned kDNA sequences showed different taxonomic specificities demonstrating sequence diversity within

  11. Generation of Individual Whole-Brain Atlases With Resting-State fMRI Data Using Simultaneous Graph Computation and Parcellation.

    Science.gov (United States)

    Wang, J; Hao, Z; Wang, H

    2018-01-01

    The human brain can be characterized as functional networks. Therefore, it is important to subdivide the brain appropriately in order to construct reliable networks. Resting-state functional connectivity-based parcellation is a commonly used technique to fulfill this goal. Here we propose a novel individual subject-level parcellation approach based on whole-brain resting-state functional magnetic resonance imaging (fMRI) data. We first used a supervoxel method known as simple linear iterative clustering directly on resting-state fMRI time series to generate supervoxels, and then combined similar supervoxels to generate clusters using a clustering method known as graph-without-cut (GWC). The GWC approach incorporates spatial information and multiple features of the supervoxels by energy minimization, simultaneously yielding an optimal graph and brain parcellation. Meanwhile, it theoretically guarantees that the actual cluster number is exactly equal to the initialized cluster number. By comparing the results of the GWC approach and those of the random GWC approach, we demonstrated that GWC does not rely heavily on spatial structures, thus avoiding the challenges encountered in some previous whole-brain parcellation approaches. In addition, by comparing the GWC approach to two competing approaches, we showed that GWC achieved better parcellation performances in terms of different evaluation metrics. The proposed approach can be used to generate individualized brain atlases for applications related to cognition, development, aging, disease, personalized medicine, etc. The major source codes of this study have been made publicly available at https://github.com/yuzhounh/GWC.

  12. Compact, diode-pumped, solid-state lasers for next generation defence and security sensors

    Science.gov (United States)

    Silver, M.; Lee, S. T.; Borthwick, A.; McRae, I.; Jackson, D.; Alexander, W.

    2015-06-01

    Low-cost semiconductor laser diode pump sources have made a dramatic impact in sectors such as advanced manufacturing. They are now disrupting other sectors, such as defence and security (D&S), where Thales UK is a manufacturer of sensor systems for application on land, sea, air and man portable. In this talk, we will first give an overview of the market trends and challenges in the D&S sector. Then we will illustrate how low cost pump diodes are enabling new directions in D&S sensors, by describing two diode pumped, solid- state laser products currently under development at Thales UK. The first is a new generation of Laser Target Designators (LTD) that are used to identify targets for the secure guiding of munitions. Current systems are bulky, expensive and require large battery packs to operate. The advent of low cost diode technology, merged with our novel solid-state laser design, has created a designator that will be the smallest, lowest cost, STANAG compatible laser designator on the market. The LTD delivers greater that 50mJ per pulse up to 20Hz, and has compact dimensions of 125×70×55mm. Secondly, we describe an ultra-compact, eye-safe, solid-state laser rangefinder (LRF) with reduced size, weight and power consumption compared to existing products. The LRF measures 100×55×34mm, weighs 200g, and can range to greater than 10km with a single laser shot and at a reprate of 1Hz. This also leverages off advances in laser pump diodes, but also utilises low cost, high reliability, packaging technology commonly found in the telecoms sector. As is common in the D&S sector, the products are designed to work in extreme environments, such as wide temperature range (-40 to +71°C) and high levels of shock and vibration. These disruptive products enable next- generation laser sensors such as rangefinders, target designators and active illuminated imagers.

  13. Solid-state photoelectrochemical H2 generation with gaseous reactants

    International Nuclear Information System (INIS)

    Iwu, Kingsley O.; Galeckas, Augustinas; Kuznetsov, Andrej Yu.; Norby, Truls

    2013-01-01

    Photocurrent and H 2 production were demonstrated in an all solid-state photoelectrochemical cell employing gaseous methanol and water vapour at the photoanode. Open circuit photovoltage of around −0.4 V and short circuit photocurrent of up to 250 μA/cm 2 were obtained. At positive bias, photocurrent generation was limited by the irradiance, i.e., the amount of photogenerated charge carriers at the anode. Time constants and impedance spectra showed an electrochemical capacitance of the cell of about 15 μF/cm 2 in the dark, which increased with increasing irradiance. With only water vapour at the anode, the short circuit photocurrent was about 6% of the value with gaseous methanol and water vapour. The photoanode and electrocatalyst on carbon paper support were affixed to the proton conducting membrane using Nafion ® as adhesive, an approach that yielded photocurrents up to 15 times better than that of a cell assembled by hot-pressing, in spite of the overall cell resistance of the latter being up to five times less than that of the former. This is attributed, at least partially, to reactants being more readily available at the photoanode of the better performing cell

  14. Simple and efficient generation of gap solitons in Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Matuszewski, Michal; Krolikowski, Wieslaw; Trippenbach, Marek; Kivshar, Yuri S.

    2006-01-01

    We suggest an efficient method for generating matter-wave gap solitons in a repulsive Bose-Einstein condensate, when the gap soliton is formed from a condensate cloud in a harmonic trap after turning on a one-dimensional optical lattice. We demonstrate numerically that this approach does not require preparing the initial atomic wave packet in a specific state corresponding to the edge of the Brillouin zone of the spectrum, and losses that occur during the soliton generation process can be suppressed by an appropriate adiabatic switching of the optical lattice

  15. Greenberger-Horne-Zeilinger state generation of three atoms trapped in two remote cavities

    International Nuclear Information System (INIS)

    Li Yanling; Fang Maofa; Xiao Xing; Zeng Ke; Wu Chao

    2010-01-01

    We consider a system composed of a single-atom-trapped cavity (A) and a remote two-atom-trapped cavity (B) which are connected by an optical fibre. It is shown that a shared Greenberger-Horne-Zeilinger (GHZ) state of the three atoms can be deterministically generated by controlling the time of interaction or via the adiabatic passage based on this system. The influence of various decoherence processes such as spontaneous emission and photon loss on the fidelity is also investigated. It is found that our schemes can be realized with high fidelity even when these decoherence processes are considered.

  16. Greenberger-Horne-Zeilinger state generation of three atoms trapped in two remote cavities

    Energy Technology Data Exchange (ETDEWEB)

    Li Yanling; Fang Maofa; Xiao Xing; Zeng Ke; Wu Chao, E-mail: mffang@hunnu.edu.c [Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control, Ministry of Education, and College of Physics and Information Science, Hunan Normal University, Changsha 410081 (China)

    2010-04-28

    We consider a system composed of a single-atom-trapped cavity (A) and a remote two-atom-trapped cavity (B) which are connected by an optical fibre. It is shown that a shared Greenberger-Horne-Zeilinger (GHZ) state of the three atoms can be deterministically generated by controlling the time of interaction or via the adiabatic passage based on this system. The influence of various decoherence processes such as spontaneous emission and photon loss on the fidelity is also investigated. It is found that our schemes can be realized with high fidelity even when these decoherence processes are considered.

  17. Inventory of power plants in the United States as of January 1, 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The Inventory of Power Plants in the United States provides annual statistics on generating units operated by electric utilities in the US (the 50 States and the District of Columbia). Statistics presented in this report reflect the status of generating units as of January 1, 1998. The publication also provides a 10-year outlook for generating unit additions and generating unit changes. This report is prepared annually by the Energy Information Administration (EIA). Data summarized in this report are useful to a wide audience. This is a report of electric utility data; in cases where summary data or nonconfidential data of nonutilities are presented, it is specifically noted as nonutility data. 19 figs., 36 tabs.

  18. Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

    International Nuclear Information System (INIS)

    1994-02-01

    This report is DOE's first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992

  19. Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This report is DOE`s first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992.

  20. Modeling and Maximum Power Point Tracking Control of Wind Generating Units Equipped with Permanent Magnet Synchronous Generators in Presence of Losses

    Directory of Open Access Journals (Sweden)

    Andrea Bonfiglio

    2017-01-01

    Full Text Available This paper focuses on the modeling of wind turbines equipped with direct drive permanent magnet synchronous generators for fundamental frequency power system simulations. Specifically, a procedure accounting for the system active power losses to initialize the simulation starting from the load flow results is proposed. Moreover, some analytical assessments are detailed on typical control schemes for fully rated wind turbine generators, thereby highlighting how active power losses play a fundamental role in the effectiveness of the wind generator control algorithm. Finally, the paper proposes analytical criteria to design the structure and the parameters of the regulators of the wind generator control scheme. Simulations performed with Digsilent Power Factory validated the proposed procedure, highlighting the impact of active power losses on the characterization of the initial steady state and that the simplifying assumptions done in order to synthesize the controllers are consistent with the complete modeling performed by the aforementioned power system simulator.

  1. Modernization perspectives of the Sao Paulo State sugarcane sector through the clean development mechanism and potential carbon credits generation

    Energy Technology Data Exchange (ETDEWEB)

    Coelho, Suani Teixeira; Lora, Beatriz Acquaro [Brazilian Reference Center on Biomass (CENBIO/USP), SP (Brazil)], Emails: suani@iee.usp.br, blora@iee.usp.br

    2009-07-01

    The world-wide necessity of greenhouse gases mitigation and the intergovernmental mobilization to reach the objectives established by the United Nations Framework on Climate Change (UNFCCC) has opened space for the renewable energy increase in the world's energy matrix. In Brazil, the solid sugarcane industry currently develops business in the scope of the clean development mechanism (CDM) under the Kyoto's Protocol, by means of 18 biomass-based projects, with renewable energy generation through bagasse cogeneration at 20 Sao Paulo State's sugarcane production units. The projects activity's consists of increasing the efficiency in the bagasse cogeneration facilities, qualifying the units to sell surplus electricity to the national grid, avoiding the dispatch of the same amount of energy produced by fossil-fuelled thermal plants to that grid. The reduced emissions are measured in carbon equivalent and can be converted into negotiable credits. The objective of this study was to build a 'state of art' scenario, calculating the potential emissions reduction through CDM projects for the sugarcane sector of Sao Paulo State, in which we consider the adherence of all the production units of the State to the CDM projects. The technological parameters used to elaborate the scenario were provided by the Sao Paulo State Government Bioenergy Special Commission and the baseline factor used of 0,268 tCO{sub 2}e/MWh was the adopted by the CDM projects in operation in the State. The sugarcane database for the calculations was the production ranking provided by UNICA for the 2006/2007 season. In the most conservative scenario (40 bar bagasse) 131 units could generate 607 MWm of surplus power avoiding the emission of 1.404.593 tCO{sub 2}e/year. For the 92 bar (bagasse and straw) scenario, the units could generate 3.055 MWm of surplus power avoiding 12.199.443 tCO{sub 2}e/year. (author)

  2. Potential air quality benefits from increased solar photovoltaic electricity generation in the Eastern United States

    Energy Technology Data Exchange (ETDEWEB)

    Abel, David; Holloway, Tracey; Harkey, Monica; Rrushaj, Arber; Brinkman, Greg; Duran, Phillip; Janssen, Mark; Denholm, Paul

    2018-02-01

    We evaluate how fine particulate matter (PM2.5) and precursor emissions could be reduced if 17% of electricity generation was replaced with solar photovoltaics (PV) in the Eastern United States. Electricity generation is simulated using GridView, then used to scale electricity-sector emissions of sulfur dioxide (SO2) and nitrogen oxides (NOX) from an existing gridded inventory of air emissions. This approach offers a novel method to leverage advanced electricity simulations with state-of-the-art emissions inventories, without necessitating recalculation of emissions for each facility. The baseline and perturbed emissions are input to the Community Multiscale Air Quality Model (CMAQ version 4.7.1) for a full accounting of time- and space-varying air quality changes associated with the 17% PV scenario. These results offer a high-value opportunity to evaluate the reduced-form AVoided Emissions and geneRation Tool (AVERT), while using AVERT to test the sensitivity of results to changing base-years and levels of solar integration. We find that average NOX and SO2 emissions across the region decrease 20% and 15%, respectively. PM2.5 concentrations decreased on average 4.7% across the Eastern U.S., with nitrate (NO3-) PM2.5 decreasing 3.7% and sulfate (SO42-) PM2.5 decreasing 9.1%. In the five largest cities in the region, we find that the most polluted days show the most significant PM2.5 decrease under the 17% PV generation scenario, and that the greatest benefits are accrued to cities in or near the Ohio River Valley. We find summer health benefits from reduced PM2.5 exposure estimated as 1424 avoided premature deaths (95% Confidence Interval (CI): 284 deaths, 2 732 deaths) or a health savings of $13.1 billion (95% CI: $0.6 billion, $43.9 billion) These results highlight the potential for renewable energy as a tool for air quality managers to support current and future health-based air quality regulations.

  3. Potential air quality benefits from increased solar photovoltaic electricity generation in the Eastern United States

    Science.gov (United States)

    Abel, David; Holloway, Tracey; Harkey, Monica; Rrushaj, Arber; Brinkman, Greg; Duran, Phillip; Janssen, Mark; Denholm, Paul

    2018-02-01

    We evaluate how fine particulate matter (PM2.5) and precursor emissions could be reduced if 17% of electricity generation was replaced with solar photovoltaics (PV) in the Eastern United States. Electricity generation is simulated using GridView, then used to scale electricity-sector emissions of sulfur dioxide (SO2) and nitrogen oxides (NOX) from an existing gridded inventory of air emissions. This approach offers a novel method to leverage advanced electricity simulations with state-of-the-art emissions inventories, without necessitating recalculation of emissions for each facility. The baseline and perturbed emissions are input to the Community Multiscale Air Quality Model (CMAQ version 4.7.1) for a full accounting of time- and space-varying air quality changes associated with the 17% PV scenario. These results offer a high-value opportunity to evaluate the reduced-form AVoided Emissions and geneRation Tool (AVERT), while using AVERT to test the sensitivity of results to changing base-years and levels of solar integration. We find that average NOX and SO2 emissions across the region decrease 20% and 15%, respectively. PM2.5 concentrations decreased on average 4.7% across the Eastern U.S., with nitrate (NO3-) PM2.5 decreasing 3.7% and sulfate (SO42-) PM2.5 decreasing 9.1%. In the five largest cities in the region, we find that the most polluted days show the most significant PM2.5 decrease under the 17% PV generation scenario, and that the greatest benefits are accrued to cities in or near the Ohio River Valley. We find summer health benefits from reduced PM2.5 exposure estimated as 1424 avoided premature deaths (95% Confidence Interval (CI): 284 deaths, 2 732 deaths) or a health savings of 13.1 billion (95% CI: 0.6 billion, 43.9 billion) These results highlight the potential for renewable energy as a tool for air quality managers to support current and future health-based air quality regulations.

  4. Logarithmic-function generator

    Science.gov (United States)

    Caron, P. R.

    1975-01-01

    Solid-state logarithmic-function generator is compact and provides improved accuracy. Generator includes a stable multivibrator feeding into RC circuit. Resulting exponentially decaying voltage is compared with input signal. Generator output is proportional to time required for exponential voltage to decay from preset reference level to level of input signal.

  5. Isotope identification as a part of the decommissioning of San Diego State University's Texas Nuclear neutron generator

    International Nuclear Information System (INIS)

    Taylor, D.

    1997-07-01

    The Department of Physics at San Diego State University has maintained a Neutron Generator facility in room P-32C since the mid 1960's. This facility has provided students and faculty with a resource for the study of neutron interactions with matter, such as activation analysis, flux determinations, cross section determinations and shielding studies. The model 9500 was built by Texas Nuclear Research in the early 1960's, and could be used for either photon or neutron generation, depending on the source ions introduced into the accelerator's plasma bottle and the target material. In February of 1988, the Texas Nuclear Research neutron generator was replaced by a unit manufactured by Kaman Sciences Corporation. The Texas Nuclear unit was then removed and stored for later disassembly and disposal. In the summer of 1993, the neutron generator was disassembled into three large sections consisting of the titanium-tritide target, the oil diffusion pump and the corona shield/accelerator tube assembly. The target was packaged and stored in room P-33A and the other 2 assemblies were wrapped in plastic for storage. In June of 1995 the neutron generator was further disassembled to enable storage in 55 gallon drums and thoroughly surveyed for loose surface contamination. Openings on the disassembled hardware components were closed off using either duct tape or bolted stainless steel flanges to prevent the possible spread of contamination. Significant levels of removable surface contamination could be found on system internal and some external surfaces, up to five hundred thousand disintegrations per minute. Initial analysis of the removable contamination using aluminum absorbers and a Geiger-Meuller tube indicated beta particle or possibly photon emitters with an energy of approximately 180 keV. This apparent radiation energy conflicted with what one would be expected to find, given knowledge of the source material and the possible neutron activated products that would be

  6. High-efficency stable 213-nm generation for LASIK application

    Science.gov (United States)

    Wang, Zhenglin; Alameh, Kamal; Zheng, Rong

    2005-01-01

    213nm Solid-state laser technology provides an alternative method to replace toxic excimer laser in LASIK system. In this paper, we report a compact fifth harmonic generation system to generate high pulse energy 213nm laser from Q-switched Nd:YAG laser for LASIK application based on three stages harmonic generation procedures. A novel crystal housing was specifically designed to hold the three crystals with each crystal has independent, precise angular adjustment structure and automatic tuning control. The crystal temperature is well maintained at ~130°C to improve harmonic generation stability and crystal operation lifetime. An output pulse energy 35mJ is obtained at 213nm, corresponding to total conversion efficiency ~10% from 1064nm pump laser. In system verification tests, the 213nm output power drops less than 5% after 5 millions pulse shots and no significant damage appears in the crystals.

  7. Generation of Recombinant Monoclonal Antibodies from Immunised Mice and Rabbits via Flow Cytometry and Sorting of Antigen-Specific IgG+ Memory B Cells.

    Directory of Open Access Journals (Sweden)

    Dale O Starkie

    Full Text Available Single B cell screening strategies, which avoid both hybridoma fusion and combinatorial display, have emerged as important technologies for efficiently sampling the natural antibody repertoire of immunized animals and humans. Having access to a range of methods to interrogate different B cell subsets provides an attractive option to ensure large and diverse panels of high quality antibody are produced. The generation of multiple antibodies and having the ability to find rare B cell clones producing IgG with unique and desirable characteristics facilitates the identification of fit-for-purpose molecules that can be developed into therapeutic agents or research reagents. Here, we describe a multi-parameter flow cytometry single-cell sorting technique for the generation of antigen-specific recombinant monoclonal antibodies from single IgG+ memory B cells. Both mouse splenocytes and rabbit PBMC from immunised animals were used as a source of B cells. Reagents staining both B cells and other unwanted cell types enabled efficient identification of class-switched IgG+ memory B cells. Concurrent staining with antigen labelled separately with two spectrally-distinct fluorophores enabled antigen-specific B cells to be identified, i.e. those which bind to both antigen conjugates (double-positive. These cells were then typically sorted at one cell per well using FACS directly into a 96-well plate containing reverse transcriptase reaction mix. Following production of cDNA, PCR was performed to amplify cognate heavy and light chain variable region genes and generate transcriptionally-active PCR (TAP fragments. These linear expression cassettes were then used directly in a mammalian cell transfection to generate recombinant antibody for further testing. We were able to successfully generate antigen-specific recombinant antibodies from both the rabbit and mouse IgG+ memory B cell subset within one week. This included the generation of an anti-TNFR2 blocking

  8. Extension of modified RAND to multiphase flash specifications based on state functions other than (T,P)

    DEFF Research Database (Denmark)

    Paterson, Duncan; Michelsen, Michael Locht; Yan, Wei

    2017-01-01

    The recently proposed modified RAND formulation is extended from isothermal multiphase flash to several other state function based flash specifications. The obtained general formulation is applicable to chemical equilibrium although this study is focused on flash with only phase equilibrium. It i...

  9. Displacement of microwave squeezed states with Josephson parametric amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Ling; Baust, Alexander; Xie, Edwar; Schwarz, Manuel; Gross, Rudolf [Walther-Meissner-Institut, Bayerische Akademie der Wissenschaften, Garching (Germany); Physik-Department, TU Muenchen, Garching (Germany); Nanosystems Initiative Munich (NIM), Muenchen (Germany); Fedorov, Kirill; Menzel, Edwin; Marx, Achim [Walther-Meissner-Institut, Bayerische Akademie der Wissenschaften, Garching (Germany); Betzenbichler, Martin; Pogorzalek, Stefan; Haeberlein, Max; Eder, Peter; Goetz, Jan; Wulschner, Karl Friedrich; Huebl, Hans; Deppe, Frank [Walther-Meissner-Institut, Bayerische Akademie der Wissenschaften, Garching (Germany); Physik-Department, TU Muenchen, Garching (Germany)

    2015-07-01

    Propagating quantum microwaves are promising building blocks for quantum communication. Interestingly, such itinerant quantum microwaves can be generated in the form of squeezed photon states by Josephson parametric amplifiers (JPA). We employ a specific ''dual-path'' setup for both state reconstruction and JPA characterization. Displacement operations are performed by using a directional coupler after the squeezing. We compare our results with theory predictions. In particular, we discuss our experiments in the context of remote state preparation and quantum teleportation with propagating microwaves.

  10. Experimental Testing of a Van De Graaff Generator as an Electromagnetic Pulse Generator

    Science.gov (United States)

    2016-07-01

    EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR THESIS...protection in the United States AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR...RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR

  11. Brand-Specific Consumption of Flavored Alcoholic Beverages among Underage Youth in the United States

    Science.gov (United States)

    Fortunato, Erin K.; Siegel, Michael; Ramirez, Rebecca L.; Ross, Craig; DeJong, William; Albers, Alison B.; Jernigan, David H.

    2013-01-01

    Background Although several studies have identified flavored alcoholic beverages (FABs) as being popular among underage drinkers, no previous study has ascertained the prevalence of brand-specific FAB consumption among a national sample of underage youth. Objectives To ascertain the brand-specific consumption prevalence and consumption share of FABs among a national sample of underage drinkers in the United States. Methods In 2012, we conducted an online, self-administered survey of a national sample of 1,031 underage drinkers, ages 13-20, to determine the prevalence of past 30-day consumption for each of 898 alcoholic beverage brands, including 62 FABs, and each brand’s youth consumption share, based on the estimated total number of standard drinks consumed. There were three brand-specific outcome measures: prevalence of consumption, prevalence of consumption during heavy episodic drinking, and consumption share, defined as the percentage of the total drinks consumed by all respondents combined that was attributable to a particular brand. Results The FAB brands with the highest prevalence of past 30-day consumption were Smirnoff Malt Beverages, 17.7%; Mike’s, 10.8%; Bacardi Malt Beverages, 8.0%; and Four Loko/Four MaXed, 6.1%. Just five brands accounted for almost half (49.1%) of the total consumption share by volume within the FAB category. Conclusion Flavored alcoholic beverages are highly popular among underage drinkers, and their FAB brand preferences are highly concentrated among a small number of brands. To decrease the consumption of FABs by underage youth, all states should re-classify these beverages as distilled spirits rather than beer. PMID:24266600

  12. Generation of Triplet Excited States via Photoinduced Electron Transfer in meso-anthra-BODIPY: Fluorogenic Response toward Singlet Oxygen in Solution and in Vitro

    KAUST Repository

    Filatov, Mikhail A.; Karuthedath, Safakath; Polestshuk, Pavel M.; Savoie, Huguette; Flanagan, Keith J.; Sy, Cindy; Sitte, Elisabeth; Telitchko, Maxime; Laquai, Fré dé ric; Boyle, Ross W.; Senge, Mathias O.

    2017-01-01

    Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced electron transfer (PeT), followed by recombination of the resulting charge-separated states (CSS). Subsequent quenching of the triplet states by molecular oxygen produces singlet oxygen (1O2), which reacts with the anthracene moiety yielding highly fluorescent species. The steric demand of the alkyl substituents in the BODIPY subunit defines the site of 1O2 addition. Novel bis- and tetraepoxides and bicyclic acetal products, arising from rearrangements of anthracene endoperoxides were isolated and characterized. 1O2 generation by BADs in living cells enables visualization of the dyads distribution, promising new imaging applications.

  13. Generation of Triplet Excited States via Photoinduced Electron Transfer in meso-anthra-BODIPY: Fluorogenic Response toward Singlet Oxygen in Solution and in Vitro

    KAUST Repository

    Filatov, Mikhail A.

    2017-04-14

    Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced electron transfer (PeT), followed by recombination of the resulting charge-separated states (CSS). Subsequent quenching of the triplet states by molecular oxygen produces singlet oxygen (1O2), which reacts with the anthracene moiety yielding highly fluorescent species. The steric demand of the alkyl substituents in the BODIPY subunit defines the site of 1O2 addition. Novel bis- and tetraepoxides and bicyclic acetal products, arising from rearrangements of anthracene endoperoxides were isolated and characterized. 1O2 generation by BADs in living cells enables visualization of the dyads distribution, promising new imaging applications.

  14. Auxiliary Deep Generative Models

    DEFF Research Database (Denmark)

    Maaløe, Lars; Sønderby, Casper Kaae; Sønderby, Søren Kaae

    2016-01-01

    Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning. We extend deep generative models with auxiliary variables which improves the variational approximation. The auxiliary variables leave...... the generative model unchanged but make the variational distribution more expressive. Inspired by the structure of the auxiliary variable we also propose a model with two stochastic layers and skip connections. Our findings suggest that more expressive and properly specified deep generative models converge...... faster with better results. We show state-of-the-art performance within semi-supervised learning on MNIST (0.96%), SVHN (16.61%) and NORB (9.40%) datasets....

  15. Status of thermal power generation in India-Perspectives on capacity, generation and carbon dioxide emissions

    International Nuclear Information System (INIS)

    Ghosh, Subhodip

    2010-01-01

    India's reliance on fossil-fuel based electricity generation has aggravated the problem of high carbon dioxide (CO 2 ) emissions from combustion of fossil fuels, primarily coal, in the country's energy sector. The objective of this paper is to analyze thermal power generation in India for a four-year period and determine the net generation from thermal power stations and the total and specific CO 2 emissions. The installed generating capacity, net generation and CO 2 emissions figures for the plants have been compared and large generators, large emitters, fuel types and also plant vintage have been identified. Specific emissions and dates of commissioning of plants have been taken into account for assessing whether specific plants need to be modernized. The focus is to find out areas and stations which are contributing more to the total emissions from all thermal power generating stations in the country and identify the overall trends that are emerging.

  16. Generation of Individual Whole-Brain Atlases With Resting-State fMRI Data Using Simultaneous Graph Computation and Parcellation

    Directory of Open Access Journals (Sweden)

    J. Wang

    2018-05-01

    Full Text Available The human brain can be characterized as functional networks. Therefore, it is important to subdivide the brain appropriately in order to construct reliable networks. Resting-state functional connectivity-based parcellation is a commonly used technique to fulfill this goal. Here we propose a novel individual subject-level parcellation approach based on whole-brain resting-state functional magnetic resonance imaging (fMRI data. We first used a supervoxel method known as simple linear iterative clustering directly on resting-state fMRI time series to generate supervoxels, and then combined similar supervoxels to generate clusters using a clustering method known as graph-without-cut (GWC. The GWC approach incorporates spatial information and multiple features of the supervoxels by energy minimization, simultaneously yielding an optimal graph and brain parcellation. Meanwhile, it theoretically guarantees that the actual cluster number is exactly equal to the initialized cluster number. By comparing the results of the GWC approach and those of the random GWC approach, we demonstrated that GWC does not rely heavily on spatial structures, thus avoiding the challenges encountered in some previous whole-brain parcellation approaches. In addition, by comparing the GWC approach to two competing approaches, we showed that GWC achieved better parcellation performances in terms of different evaluation metrics. The proposed approach can be used to generate individualized brain atlases for applications related to cognition, development, aging, disease, personalized medicine, etc. The major source codes of this study have been made publicly available at https://github.com/yuzhounh/GWC.

  17. Generating optimal states for a homodyne Bell test

    International Nuclear Information System (INIS)

    Daffer, S.; Knight, P.L.

    2005-01-01

    Full text: We present a protocol that produces a conditionally prepared state that can be used for a Bell test based on homodyne detection. Based on the results of Munro, the state is near-optimal for Bell inequality violations based on quadrature-phase homodyne measurements that use correlated photon-number states. The scheme utilizes the Gaussian entanglement distillation protocol of Eisert et. al. and uses only beam splitters and photodetection to conditionally prepare a non-Gaussian state from a source of two-mode squeezed states with low squeezing parameter, permitting a loophole-free test of Bell inequalities. (author)

  18. Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models

    Science.gov (United States)

    Cebrian-Serrano, Alberto; Zha, Shijun; Hanssen, Lars; Biggs, Daniel; Preece, Christopher

    2017-01-01

    Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced. Successful genome manipulation in the mouse has already been reported using Cas9 supplied by microinjection of a DNA construct, in vitro transcribed mRNA and recombinant protein. Recently the use of transgenic strains of mice overexpressing Cas9 has been shown to facilitate site-specific mutagenesis via maternal supply to zygotes and this route may provide an alternative to exogenous supply. We have investigated the feasibility of supplying Cas9 genetically in more detail and for this purpose we report the generation of a transgenic mice which overexpress Cas9 ubiquitously, via a CAG-Cas9 transgene targeted to the Gt(ROSA26)Sor locus. We show that zygotes prepared from female mice harbouring this transgene are sufficiently loaded with maternally contributed Cas9 for efficient production of embryos and mice harbouring indel, genomic deletion and knock-in alleles by microinjection of guide RNAs and templates alone. We compare the mutagenesis rates and efficacy of mutagenesis using this genetic supply with exogenous Cas9 supply by either mRNA or protein microinjection. In general, we report increased generation rates of knock-in alleles and show that the levels of mutagenesis at certain genome target sites are significantly higher and more consistent when Cas9 is supplied genetically relative to exogenous supply. PMID:28081254

  19. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process.

    Science.gov (United States)

    Hobson, J A; McCarley, R W

    1977-12-01

    Recent research in the neurobiology of dreaming sleep provides new evidence for possible structural and functional substrates of formal aspects of the dream process. The data suggest that dreaming sleep is physiologically determined and shaped by a brain stem neuronal mechanism that can be modeled physiologically and mathematically. Formal features of the generator processes with strong implications for dream theory include periodicity and automaticity of forebrain activation, suggesting a preprogrammed neural basis for dream mentation in sleep; intense and sporadic activation of brain stem sensorimotor circuits including reticular, oculomotor, and vestibular neurons, possibly determining spatiotemporal aspects of dream imagery; and shifts in transmitter ratios, possibly accounting for dream amnesia. The authors suggest that the automatically activated forebrain synthesizes the dream by comparing information generated in specific brain stem circuits with information stored in memory.

  20. Changing Welfare States and the “Sandwich Generation” : Increasing Burden for the Next Generation?

    Directory of Open Access Journals (Sweden)

    Harald Künemund

    2006-12-01

    Full Text Available The burden placed on individuals aged 40 to 59 – especially on women – by competing demands from work and both older and younger family members is often addressed using the metaphor of the „sandwich gen-eration“. Based on a systematization of the definitions used in the litera-ture, empirical evidence on the frequency of such generational constella-tions and on their impact on the well-being of sandwiched adults will be presented. Analysing the second wave of the German Aging Survey shows that being sandwiched – defined as a generational constellation – is very common, but simultaneous care activities for both older and younger family members are rare, especially in combination with labour force participation, and that life satisfaction is not systematically related to being sandwiched. Implications for further research and future devel-opments will be discussed, especially with respect to changes in family structure (e.g. the beanpole family and changes in the amount of welfare state spending for the aged.

  1. 75 FR 44292 - Northern States Power Company; Prairie Island Nuclear Generating Plant, Units 1 and 2; Notice of...

    Science.gov (United States)

    2010-07-28

    ... and DPR-60] Northern States Power Company; Prairie Island Nuclear Generating Plant, Units 1 and 2... assessment, and behavioral observation) of the unescorted access authorization program when making the... under consideration to determine whether it met the criteria established in NRC Management Directive (MD...

  2. Estimating Renewable Energy Economic Potential in the United States. Methodology and Initial Results

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Austin; Beiter, Philipp; Heimiller, Donna; Davidson, Carolyn; Denholm, Paul; Melius, Jennifer; Lopez, Anthony; Hettinger, Dylan; Mulcahy, David; Porro, Gian

    2016-08-01

    This report describes a geospatial analysis method to estimate the economic potential of several renewable resources available for electricity generation in the United States. Economic potential, one measure of renewable generation potential, may be defined in several ways. For example, one definition might be expected revenues (based on local market prices) minus generation costs, considered over the expected lifetime of the generation asset. Another definition might be generation costs relative to a benchmark (e.g., a natural gas combined cycle plant) using assumptions of fuel prices, capital cost, and plant efficiency. Economic potential in this report is defined as the subset of the available resource technical potential where the cost required to generate the electricity (which determines the minimum revenue requirements for development of the resource) is below the revenue available in terms of displaced energy and displaced capacity. The assessment is conducted at a high geospatial resolution (more than 150,000 technology-specific sites in the continental United States) to capture the significant variation in local resource, costs, and revenue potential. This metric can be a useful screening factor for understanding the economic viability of renewable generation technologies at a specific location. In contrast to many common estimates of renewable energy potential, economic potential does not consider market dynamics, customer demand, or most policy drivers that may incent renewable energy generation.

  3. Cognitive Language and Content Standards: Language Inventory of the Common Core State Standards in Mathematics and the Next Generation Science Standards

    Science.gov (United States)

    Winn, Kathleen M.; Mi Choi, Kyong; Hand, Brian

    2016-01-01

    STEM education is a current focus of many educators and policymakers and the Next Generation Science Standards (NGSS) with the Common Core State Standards in Mathematics (CCSSM) are foundational documents driving curricular and instructional decision making for teachers and students in K-8 classrooms across the United States. Thus, practitioners…

  4. Renewable energy and sustainable communities: Alaska's wind generator experience.

    Science.gov (United States)

    Konkel, R Steven

    2013-01-01

    In 1984, the Alaska Department of Commerce and Economic Development (DCED) issued the State's first inventory/economic assessment of wind generators, documenting installed wind generator capacity and the economics of replacing diesel-fuel-generated electricity. Alaska's wind generation capacity had grown from hundreds of installed kilowatts to over 15.3 megawatts (MW) by January 2012. This article reviews data and conclusions presented in "Alaska's Wind Energy Systems; Inventory and Economic Assessment" (1). (Alaska Department of Commerce and Economic Development, S. Konkel, 1984). It provides a foundation and baseline for understanding the development of this renewable energy source. Today's technologies have evolved at an astonishing pace; a typical generator in an Alaska wind farm now is likely rated at 1.5-MW capacity, compared to the single-kilowatt (kW) machines present in 1984. Installed capacity has mushroomed, illustrated by Unalakleet's 600-kW wind farm dwarfing the original three 10-kW machines included in the 1984 inventory. Kodiak Electric had three 1.5-MW turbines installed at Pillar Mountain in 2009, with three additional turbines of 4.5-MW capacity installed in 2012. Utilities now actively plan for wind generation and compete for state funding. State of Alaska energy policy provides the context for energy project decision-making. Substantial renewable energy fund (REF) awards--$202,000,000 to date for 227 REF projects in the first 5 cycles of funding--along with numerous energy conservation programs--are now in place. Increasing investment in wind is driven by multiple factors. Stakeholders have interests both in public policy and meeting private investment objectives. Wind generator investors should consider project economics and potential impacts of energy decisions on human health. Specifically this article considers: changing environmental conditions in remote Alaska villages, impacts associated with climate change on human health, progress in

  5. Sensor-Based Trajectory Generation for Advanced Driver Assistance System

    Directory of Open Access Journals (Sweden)

    Christopher James Shackleton

    2013-03-01

    Full Text Available This paper investigates the trajectory generation problem for an advanced driver assistance system that could sense the driving state of the vehicle, so that a collision free trajectory can be generated safely. Specifically, the problem of trajectory generation is solved for the safety assessment of the driving state and to manipulate the vehicle in order to avoid any possible collisions. The vehicle senses the environment so as to obtain information about other vehicles and static obstacles ahead. Vehicles may share the perception of the environment via an inter-vehicle communication system. The planning algorithm is based on a visibility graph. A lateral repulsive potential is applied to adaptively maintain a trade-off between the trajectory length and vehicle clearance, which is the greatest problem associated with visibility graphs. As opposed to adaptive roadmap approaches, the algorithm exploits the structured nature of the environment for construction of the roadmap. Furthermore, the mostly organized nature of traffic systems is exploited to obtain orientation invariance, which is another limitation of both visibility graphs and adaptive roadmaps. Simulation results show that the algorithm can successfully solve the problem for a variety of commonly found scenarios.

  6. A Sweep-Line Method for State Space Exploration

    DEFF Research Database (Denmark)

    Christensen, Søren; Kristensen, Lars Michael; Mailund, Thomas

    2001-01-01

    generation, since these states can never be reached again. This in turn reduces the memory used for state space storage during the task of verification. Examples of progress measures are sequence numbers in communication protocols and time in certain models with time. We illustrate the application...... of the method on a number of Coloured Petri Net models, and give a first evaluation of its practicality by means of an implementation based on the Design/CPN state space tool. Our experiments show significant reductions in both space and time used during state space exploration. The method is not specific...... to Coloured Petri Nets but applicable to a wide range of modelling languages....

  7. Use of next generation sequencing data to develop a qPCR method for specific detection of EU-unauthorized genetically modified Bacillus subtilis overproducing riboflavin.

    Science.gov (United States)

    Barbau-Piednoir, Elodie; De Keersmaecker, Sigrid C J; Delvoye, Maud; Gau, Céline; Philipp, Patrick; Roosens, Nancy H

    2015-11-11

    Recently, the presence of an unauthorized genetically modified (GM) Bacillus subtilis bacterium overproducing vitamin B2 in a feed additive was notified by the Rapid Alert System for Food and Feed (RASFF). This has demonstrated that a contamination by a GM micro-organism (GMM) may occur in feed additives and has confronted for the first time,the enforcement laboratories with this type of RASFF. As no sequence information of this GMM nor any specific detection or identification method was available, Next GenerationSequencing (NGS) was used to generate sequence information. However, NGS data analysis often requires appropriate tools, involving bioinformatics expertise which is not alwayspresent in the average enforcement laboratory. This hampers the use of this technology to rapidly obtain critical sequence information in order to be able to develop a specific qPCRdetection method. Data generated by NGS were exploited using a simple BLAST approach. A TaqMan® qPCR method was developed and tested on isolated bacterial strains and on the feed additive directly. In this study, a very simple strategy based on the common BLAST tools that can be used by any enforcement lab without profound bioinformatics expertise, was successfully used toanalyse the B. subtilis data generated by NGS. The results were used to design and assess a new TaqMan® qPCR method, specifically detecting this GM vitamin B2 overproducing bacterium. The method complies with EU critical performance parameters for specificity, sensitivity, PCR efficiency and repeatability. The VitB2-UGM method also could detect the B. subtilis strain in genomic DNA extracted from the feed additive, without prior culturing step. The proposed method, provides a crucial tool for specifically and rapidly identifying this unauthorized GM bacterium in food and feed additives by enforcement laboratories. Moreover, this work can be seen as a case study to substantiate how the use of NGS data can offer an added value to easily

  8. Inventory of power plants in the United States 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-18

    The Inventory of Power Plants in the US provides year-end statistics on generating units operated by electric utilities in the US (the 50 States and the District of Columbia). Statistics presented in this report reflect the status of generating units as of December 31, 1994. The publication also provides a 10-year outlook for generating unit additions. This report is prepared annually by the Coal and Electric Data and Renewables Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); US Department of Energy (DOE). Data summarized in this report are useful to a wide audience including Congress, Federal, and State agencies; the electric utility industry; and the general public. This is a report of electric utility data; in cases where summary data of nonutility capacity are presented, it is specifically noted as such.

  9. Double transduction of a Cre/LoxP lentiviral vector: a simple method to generate kidney cell-specific knockdown mice.

    Science.gov (United States)

    Nam, Bo Young; Kim, Dong Ki; Park, Jung Tak; Kang, Hye-Young; Paeng, Jisun; Kim, Seonghun; Park, Jimin; Um, Jae Eun; Oh, Hyung Jung; Han, Seung Hyeok; Yoo, Tae-Hyun; Kang, Shin-Wook

    2015-12-15

    In a lentivirus-based gene delivery system, the incorporated gene is continuously expressed for a long time. In this study, we devised a simple way to knock down a specific gene in a kidney cell-specific pattern in adult mice by lentivirus-assisted transfer of short hairpin RNA (shRNA). Kidney collecting duct (CD)-specific aquaporin-3 (AQP3)-knockdown mice were generated by consecutive injection of Hoxb7-Cre-expressing lentivirus (LV-Hoxb7 Cre) and loxP-AQP3 shRNA-expressing lentivirus (LV-loxP shAQP3) in adult C57BL6/J mice. LV-Hoxb7 Cre was designed to express mCherry, while LV-loxP shAQP3 was designed with a floxed enhanced green fluorescent protein (EGFP)-tagged stop sequence, and thus EGFP would be expressed only in the absence of Cre recombination. In mice treated with LV-Hoxb7 Cre alone, mCherry protein expression, which indicates the presence of Cre recombinase, occurred only in CD cells. However, LV-loxP shAQP3 injection alone resulted in an increase in EGFP expression in all kidney cells, indicating the transcription of the floxed region. When LV-Hoxb7 Cre and LV-loxP shAQP3 were sequentially transduced, EGFP expression was attenuated while mCherry expression was sustained in CD cells, demonstrating a CD cell-specific recombination of the floxed region. AQP3 expression in mice injected with LV-Hoxb7 Cre or LV-loxP shAQP3 alone did not differ, but consecutive injection of LV-Hoxb7 Cre and LV-loxP shAQP3 significantly reduced AQP3 expression in CD cells. However, the expression levels of AQP3 were not altered in other cell types. Double transduction of Cre- and loxP-based lentivirus can easily generate kidney cell-specific knockdown mice, and this method might be applicable to other species. Copyright © 2015 the American Physiological Society.

  10. Emissions implications of downscaled electricity generation scenarios for the western United States

    Energy Technology Data Exchange (ETDEWEB)

    Nsanzineza, Rene; O’Connell, Matthew; Brinkman, Gregory; Milford, Jana B.

    2017-10-01

    This study explores how emissions from electricity generation in the Western Interconnection region of the U.S. might respond in circa 2030 to contrasting scenarios for fuel prices and greenhouse gas (GHG) emissions fees. We examine spatial and temporal variations in generation mix across the region and year using the PLEXOS unit commitment and dispatch model with a production cost model database adapted from the Western Electricity Coordinating Council. Emissions estimates are computed by combining the dispatch model results with unit-specific, emissions-load relationships. Wind energy displaces natural gas and coal in scenarios with relatively expensive natural gas or with GHG fees. Correspondingly, annual emissions of NOx, SO2, and CO2 are reduced by 20-40% in these cases. NOx emissions, which are a concern as a precursor of ground-level ozone, are relatively high and consistent across scenarios during summer, when peak electricity loads occur and wind resources in the region are comparatively weak. Accounting for the difference in start-up versus stabilized NOx emissions rates for natural gas plants had little impact on region-wide emissions estimates due to the dominant contribution from coal-fired plants, but would be more important in the vicinity of the natural gas units.

  11. Comprehension of Spacecraft Telemetry Using Hierarchical Specifications of Behavior

    Science.gov (United States)

    Havelund, Klaus; Joshi, Rajeev

    2014-01-01

    A key challenge in operating remote spacecraft is that ground operators must rely on the limited visibility available through spacecraft telemetry in order to assess spacecraft health and operational status. We describe a tool for processing spacecraft telemetry that allows ground operators to impose structure on received telemetry in order to achieve a better comprehension of system state. A key element of our approach is the design of a domain-specific language that allows operators to express models of expected system behavior using partial specifications. The language allows behavior specifications with data fields, similar to other recent runtime verification systems. What is notable about our approach is the ability to develop hierarchical specifications of behavior. The language is implemented as an internal DSL in the Scala programming language that synthesizes rules from patterns of specification behavior. The rules are automatically applied to received telemetry and the inferred behaviors are available to ground operators using a visualization interface that makes it easier to understand and track spacecraft state. We describe initial results from applying our tool to telemetry received from the Curiosity rover currently roving the surface of Mars, where the visualizations are being used to trend subsystem behaviors, in order to identify potential problems before they happen. However, the technology is completely general and can be applied to any system that generates telemetry such as event logs.

  12. Quantifying avoided fuel use and emissions from solar photovoltaic generation in the Western United States.

    Science.gov (United States)

    Denholm, Paul; Margolis, Robert M; Milford, James M

    2009-01-01

    The electric power system in the Western United States was simulated to evaluate the potential of solar photovoltaics (PV) in reducing fossil-fuel use and associated emissions. The simulations used a utility production cost model to evaluate a series of PV penetrations where up to 10% of the region's electricity is derived from PV. The analysis focused on California, which uses gas for a large fraction of its generation and Colorado, which derives most of its electricity from coal. PV displaces gas and electricity imports almost exclusively in California, with a displacement rate of about 6000-9000 kJ per kWh of PV energy generated. In Colorado, PV offsets mostly gas at low penetration, with increasing coal displacement during nonsummer months and at higher penetration. Associated reductions in CO2, NOx, and SO2 emissions are also calculated.

  13. Average subentropy, coherence and entanglement of random mixed quantum states

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Lin, E-mail: godyalin@163.com [Institute of Mathematics, Hangzhou Dianzi University, Hangzhou 310018 (China); Singh, Uttam, E-mail: uttamsingh@hri.res.in [Harish-Chandra Research Institute, Allahabad, 211019 (India); Pati, Arun K., E-mail: akpati@hri.res.in [Harish-Chandra Research Institute, Allahabad, 211019 (India)

    2017-02-15

    Compact expressions for the average subentropy and coherence are obtained for random mixed states that are generated via various probability measures. Surprisingly, our results show that the average subentropy of random mixed states approaches the maximum value of the subentropy which is attained for the maximally mixed state as we increase the dimension. In the special case of the random mixed states sampled from the induced measure via partial tracing of random bipartite pure states, we establish the typicality of the relative entropy of coherence for random mixed states invoking the concentration of measure phenomenon. Our results also indicate that mixed quantum states are less useful compared to pure quantum states in higher dimension when we extract quantum coherence as a resource. This is because of the fact that average coherence of random mixed states is bounded uniformly, however, the average coherence of random pure states increases with the increasing dimension. As an important application, we establish the typicality of relative entropy of entanglement and distillable entanglement for a specific class of random bipartite mixed states. In particular, most of the random states in this specific class have relative entropy of entanglement and distillable entanglement equal to some fixed number (to within an arbitrary small error), thereby hugely reducing the complexity of computation of these entanglement measures for this specific class of mixed states.

  14. Identifying States along the Hematopoietic Stem Cell Differentiation Hierarchy with Single Cell Specificity via Raman Spectroscopy.

    Science.gov (United States)

    Ilin, Yelena; Choi, Ji Sun; Harley, Brendan A C; Kraft, Mary L

    2015-11-17

    A major challenge for expanding specific types of hematopoietic cells ex vivo for the treatment of blood cell pathologies is identifying the combinations of cellular and matrix cues that direct hematopoietic stem cells (HSC) to self-renew or differentiate into cell populations ex vivo. Microscale screening platforms enable minimizing the number of rare HSCs required to screen the effects of numerous cues on HSC fate decisions. These platforms create a strong demand for label-free methods that accurately identify the fate decisions of individual hematopoietic cells at specific locations on the platform. We demonstrate the capacity to identify discrete cells along the HSC differentiation hierarchy via multivariate analysis of Raman spectra. Notably, cell state identification is accurate for individual cells and independent of the biophysical properties of the functionalized polyacrylamide gels upon which these cells are cultured. We report partial least-squares discriminant analysis (PLS-DA) models of single cell Raman spectra enable identifying four dissimilar hematopoietic cell populations across the HSC lineage specification. Successful discrimination was obtained for a population enriched for long-term repopulating HSCs (LT-HSCs) versus their more differentiated progeny, including closely related short-term repopulating HSCs (ST-HSCs) and fully differentiated lymphoid (B cells) and myeloid (granulocytes) cells. The lineage-specific differentiation states of cells from these four subpopulations were accurately identified independent of the stiffness of the underlying biomaterial substrate, indicating subtle spectral variations that discriminated these populations were not masked by features from the culture substrate. This approach enables identifying the lineage-specific differentiation stages of hematopoietic cells on biomaterial substrates of differing composition and may facilitate correlating hematopoietic cell fate decisions with the extrinsic cues that

  15. Sub-nanosecond jitter, repetitive impulse generators for high reliability applications

    International Nuclear Information System (INIS)

    Krausse, G.J.; Sarjeant, W.J.

    1981-01-01

    Low jitter, high reliability impulse generator development has recently become of ever increasing importance for developing nuclear physics and weapons applications. The research and development of very low jitter (< 30 ps), multikilovolt generators for high reliability, minimum maintenance trigger applications utilizing a new class of high-pressure tetrode thyratrons now commercially available are described. The overall system design philosophy is described followed by a detailed analysis of the subsystem component elements. A multi-variable experimental analysis of this new tetrode thyratron was undertaken, in a low-inductance configuration, as a function of externally available parameters. For specific thyratron trigger conditions, rise times of 18 ns into 6.0-Ω loads were achieved at jitters as low as 24 ps. Using this database, an integrated trigger generator system with solid-state front-end is described in some detail. The generator was developed to serve as the Master Trigger Generator for a large neutrino detector installation at the Los Alamos Meson Physics Facility

  16. Unitary group adapted state specific multireference perturbation theory: Formulation and pilot applications.

    Science.gov (United States)

    Sen, Avijit; Sen, Sangita; Samanta, Pradipta Kumar; Mukherjee, Debashis

    2015-04-05

    We present here a comprehensive account of the formulation and pilot applications of the second-order perturbative analogue of the recently proposed unitary group adapted state-specific multireference coupled cluster theory (UGA-SSMRCC), which we call as the UGA-SSMRPT2. We also discuss the essential similarities and differences between the UGA-SSMRPT2 and the allied SA-SSMRPT2. Our theory, like its parent UGA-SSMRCC formalism, is size-extensive. However, because of the noninvariance of the theory with respect to the transformation among the active orbitals, it requires the use of localized orbitals to ensure size-consistency. We have demonstrated the performance of the formalism with a set of pilot applications, exploring (a) the accuracy of the potential energy surface (PES) of a set of small prototypical difficult molecules in their various low-lying states, using natural, pseudocanonical and localized orbitals and compared the respective nonparallelity errors (NPE) and the mean average deviations (MAD) vis-a-vis the full CI results with the same basis; (b) the efficacy of localized active orbitals to ensure and demonstrate manifest size-consistency with respect to fragmentation. We found that natural orbitals lead to the best overall PES, as evidenced by the NPE and MAD values. The MRMP2 results for individual states and of the MCQDPT2 for multiple states displaying avoided curve crossings are uniformly poorer as compared with the UGA-SSMRPT2 results. The striking aspect of the size-consistency check is the complete insensitivity of the sum of fragment energies with given fragment spin-multiplicities, which are obtained as the asymptotic limit of super-molecules with different coupled spins. © 2015 Wiley Periodicals, Inc.

  17. Simple schemes for generation of W-type multipartite entangled states and realization of quantum-information concentration

    International Nuclear Information System (INIS)

    Deng-Yu, Zhang; Shi-Qing, Tang; Li-Jun, Xie; Xiao-Gui, Zhan; Yin-Hua, Chen; Feng, Gao

    2010-01-01

    We propose simple schemes for generating W-type multipartite entangled states in cavity quantum electrodynamics (CQED). Our schemes involve a largely detuned interaction of Λ-type three-level atoms with a single-mode cavity field and a classical laser, and both the symmetric and asymmetric W states can be created in a single step. Our schemes are insensitive to both the cavity decay and atomic spontaneous emission. With the above system, we also propose a scheme for realizing quantum-information concentration which is the reverse process of quantum cloning. In this scheme, quantum-information originally coming from a single qubit, but now distributed into many qubits, is concentrated back to a single qubit in only one step. (general)

  18. The state of radioactive waste management and of personnel radiation exposure in nuclear power generating facilities in fiscal 1983

    International Nuclear Information System (INIS)

    1985-01-01

    (1) The state of radioactive waste management in nuclear power generating facilities: In the nuclear power stations, the released quantities of radioactive gaseous and liquid wastes are all below the control objective levels. For the respective nuclear power stations, the released quantities of radioactive gaseous and liquid wastes in fiscal 1983 and the objective levels are given in table. And, the quantities of solid wastes taken into storage and the cumulative amounts are given. For reference, the results each year since fiscal 1974 are shown. (2) The state of personnel radiation exposure in nuclear power generating facilities: In the nuclear power stations, the personnel radiation exposures are all below the permissible levels. The dose distribution etc. in the respective nuclear power stations are given in table. For reference, the results each year since fiscal 1974 are shown. (Mori, K.)

  19. A Recombinant Antibody with the Antigen-Specific, Major Histocompatibility Complex-Restricted Specificity of T Cells

    Science.gov (United States)

    Andersen, Peter S.; Stryhn, Anette; Hansen, Bjarke E.; Fugger, Lars; Engberg, Jan; Buus, Soren

    1996-03-01

    Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.

  20. Steam-Generator Integrity Program/Steam-Generator Group Project

    International Nuclear Information System (INIS)

    1982-10-01

    The Steam Generator Integrity Program (SGIP) is a comprehensive effort addressing issues of nondestructive test (NDT) reliability, inservice inspection (ISI) requirements, and tube plugging criteria for PWR steam generators. In addition, the program has interactive research tasks relating primary side decontamination, secondary side cleaning, and proposed repair techniques to nondestructive inspectability and primary system integrity. The program has acquired a service degraded PWR steam generator for research purposes. This past year a research facility, the Steam Generator Examination Facility (SGEF), specifically designed for nondestructive and destructive examination tasks of the SGIP was completed. The Surry generator previously transported to the Hanford Reservation was then inserted into the SGEF. Nondestructive characterization of the generator from both primary and secondary sides has been initiated. Decontamination of the channelhead cold leg side was conducted. Radioactive field maps were established in the steam generator, at the generator surface and in the SGEF

  1. Motility, Force Generation, and Energy Consumption of Unicellular Parasites.

    Science.gov (United States)

    Hochstetter, Axel; Pfohl, Thomas

    2016-07-01

    Motility is a key factor for pathogenicity of unicellular parasites, enabling them to infiltrate and evade host cells, and perform several of their life-cycle events. State-of-the-art methods of motility analysis rely on a combination of optical tweezers with high-resolution microscopy and microfluidics. With this technology, propulsion forces, energies, and power generation can be determined so as to shed light on the motion mechanisms, chemotactic behavior, and specific survival strategies of unicellular parasites. With these new tools in hand, we can elucidate the mechanisms of motility and force generation of unicellular parasites, and identify ways to manipulate and eventually inhibit them. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Design of HIFU Transducers to Generate Specific Nonlinear Ultrasound Fields

    Science.gov (United States)

    Khokhlova, Vera A.; Yuldashev, Petr V.; Rosnitskiy, Pavel B.; Maxwell, Adam D.; Kreider, Wayne; Bailey, Michael R.; Sapozhnikov, Oleg A.

    Various clinical applications of high intensity focused ultrasound (HIFU) have different requirements on the pressure level and degree of nonlinear waveform distortion at the focus. Applications that utilize nonlinear waves with developed shocks are of growing interest, for example, for mechanical disintegration as well as for accelerated thermal ablation oftissue. In this work, an inverse problem of determining transducer parameters to enable formation of shockswith desired amplitude at the focus is solved. The solution was obtained by performing multipledirect simulations of the parabolic Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation for various parameters of the source. It is shown that results obtained within the parabolic approximation can be used to describe the focal region of single element spherical sourcesas well as complex transducer arrays. It is also demonstrated that the focal pressure level at which fully developed shocksare formed mainly depends on the focusing angle of the source and only slightly depends on its aperture and operating frequency. Using the simulation results, a 256-element HIFU array operating at 1.5 MHz frequency was designed for a specific application of boiling-histotripsy that relies on the presence of 90-100 MPa shocks at the focus. The size of the array elements and focusing angle of the array were chosen to satisfy technical limitations on the intensity at the array elements and desired shock amplitudes in the focal waveform. Focus steering capabilities of the array were analysed using an open-source T-Array software developed at Moscow State University.

  3. Magnetohydrodynamic (MHD) power generation

    International Nuclear Information System (INIS)

    Chandra, Avinash

    1980-01-01

    The concept of MHD power generation, principles of operation of the MHD generator, its design, types, MHD generator cycles, technological problems to be overcome, the current state of the art in USA and USSR are described. Progress of India's experimental 5 Mw water-gas fired open cycle MHD power generator project is reported in brief. (M.G.B.)

  4. Race to the Top. Tennessee Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

    Science.gov (United States)

    US Department of Education, 2014

    2014-01-01

    This State-specific summary report serves as an assessment of Tennessee's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. In Year 3,…

  5. Overview of the United States steam generator development programs

    Energy Technology Data Exchange (ETDEWEB)

    Kaspar, P W; Lowe, P A

    1975-07-01

    The LMFBR steam generator development program of the USA was initiated to support the development of reliable designs and meaningful performance data for these critical components. Since the steam generators include the structural boundary between heated sodium and water, the consequences of small flaws in the materials that form the boundary are significant. Successful development and demonstration of commercial LMFBR power plants requires the consideration of many factors in addition to the design, construction and operation of a particular plant. Additional factors which must be assessed include: economics, reliability, safety, environment, operability, maintainability and conservation of the resources. In terms of the steam generator these items led to the selection of a single wall tube design using a forced recirculating system for the present Clinch River Breeder Reactor. There are strong economic incentives to use a once-through steam generating system in future designs.

  6. Effects of resting state condition on reliability, trait specificity, and network connectivity of brain function measured with arterial spin labeled perfusion MRI.

    Science.gov (United States)

    Li, Zhengjun; Vidorreta, Marta; Katchmar, Natalie; Alsop, David C; Wolf, Daniel H; Detre, John A

    2018-06-01

    Resting state fMRI (rs-fMRI) provides imaging biomarkers of task-independent brain function that can be associated with clinical variables or modulated by interventions such as behavioral training or pharmacological manipulations. These biomarkers include time-averaged regional brain function as manifested by regional cerebral blood flow (CBF) measured using arterial spin labeled (ASL) perfusion MRI and correlated temporal fluctuations of function across brain networks with either ASL or blood oxygenation level dependent (BOLD) fMRI. Resting-state studies are typically carried out using just one of several prescribed state conditions such as eyes closed (EC), eyes open (EO), or visual fixation on a cross-hair (FIX), which may affect the reliability and specificity of rs-fMRI. In this study, we collected test-retest ASL MRI data during 4 resting-state task conditions: EC, EO, FIX and PVT (low-frequency psychomotor vigilance task), and examined the effects of these task conditions on reliability and reproducibility as well as trait specificity of regional brain function. We also acquired resting-state BOLD fMRI under FIX and compared the network connectivity reliabilities between the four ASL conditions and the BOLD FIX condition. For resting-state ASL data, EC provided the highest CBF reliability, reproducibility, trait specificity, and network connectivity reliability, followed by EO, while FIX was lowest on all of these measures. PVT demonstrated lower CBF reliability, reproducibility and trait specificity than EO and EC. Overall network connectivity reliability was comparable between ASL and BOLD. Our findings confirm ASL CBF as a reliable, stable, and consistent measure of resting-state regional brain function and support the use of EC or EO over FIX and PVT as the resting-state condition. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Smart IR780 Theranostic Nanocarrier for Tumor-Specific Therapy: Hyperthermia-Mediated Bubble-Generating and Folate-Targeted Liposomes.

    Science.gov (United States)

    Guo, Fang; Yu, Meng; Wang, Jinping; Tan, Fengping; Li, Nan

    2015-09-23

    The therapeutic effectiveness of chemotherapy was hampered by dose-limiting toxicity and was optimal only when tumor cells were subjected to a maximum drug exposure. The purpose of this work was to design a dual-functional thermosensitive bubble-generating liposome (BTSL) combined with conjugated targeted ligand (folate, FA) and photothermal agent (IR780), to realize enhanced therapeutic and diagnostic functions. This drug carrier was proposed to target tumor cells owing to FA-specific binding, followed by triggering drug release due to the decomposition of encapsulated ammonium bicarbonate (NH4HCO3) (generated CO2 bubbles) by being subjected to near-infrared (near-IR) laser irradiation, creating permeable defects in the lipid bilayer that rapidly release drug. In vitro temperature-triggered release study indicated the BTSL system was sensitive to heat triggering, resulting in rapid drug release under hyperthermia. For in vitro cellular uptake experiments, different results were observed on human epidermoid carcinoma cells (KB cells) and human lung cancer cells (A549 cells) due to their different (positive or negative) response to FA receptor. Furthermore, in vivo biodistribution analysis and antitumor study indicated IR780-BTSL-FA could specifically target KB tumor cells, exhibiting longer circulation time than free drug. In the pharmacodynamics experiments, IR780-BTSL-FA efficiently inhibited tumor growth in nude mice with no evident side effect to normal tissues and organs. Results of this study demonstrated that the constructed smart theranostic nanocarrier IR780-BTSL-FA might contribute to establishment of tumor-selective and effective chemotherapy.

  8. Present state and prospect of nuclear power generation

    International Nuclear Information System (INIS)

    Fukushima, Akira

    1980-01-01

    Energy resources are scarce in Japan, therefore Japan depends heavily on imported petroleum. However, the international situation of petroleum became more unstable recently, and the promotion of the development and utilization of nuclear power generation was agreed upon in the summit meeting and the IEA. In order to achieve the stable growth of economy and improve the national welfare in Japan, it is urgent subject to accelerate the development of nuclear power generation. Japan depends the nuclear fuel also on import, but the stable supply is assured by the contract of long term purchase. It is not necessary to replace nuclear fuel usually for three years, and the transport and storage of nuclear fuel are easy because the quantity is not very large. By establishing the independent nuclear fuel cycle in Japan, it is possible to give the character similar to domestically produced energy to nuclear fuel. Moreover, uranium resources can be effectively utilized by the development of nuclear reactors of new types, such as FBRs. The cost of generating 1 kWh of electricity was about 8 yen in case of nuclear power and 15 yen in petroleum thermal power as of January, 1980. 21 nuclear power plants of about 15 million kW capacity are in operation in Japan, and about 30 million kW will be installed by 1985. The measures to promote the development of nuclear power generation are discussed. (Kako, I.)

  9. Ionizing radiation affects generation of MART-1-specific cytotoxic T cell responses by dendritic cells

    International Nuclear Information System (INIS)

    Liao, Y.P.; Wang, C.-C.; McBride, W.H.

    2003-01-01

    Full text: The human MART-1/Melan-A (MART-1) melanoma tumor antigen is known to be recognized by cytotoxic T lymphocytes (CTLs) and several groups are using this target for clinical immunotherapy. Most approaches use dendritic cells (DCs) that are potent antigen presentation cells for initiating CTL responses. In order for CTL recognition to occur, DCs must display 9-residue antigenic peptides on MHC class I molecules. These peptides are generated by proteasome degradation and then transported through the endoplasmic reticulum to the cell surface where they stabilize MHC class I expression. Our previous data showed that irradiation inhibits proteasome function and, therefore, we hypothesized that irradiation may inhibit antigen processing and CTL activation, as has been shown for proteasome inhibitors. To study the importance of irradiation effects on DCs, we studied the generation MART-1-specific CTL responses. Preliminary data showed that irradiation of murine bone marrow derived DCs did not affect expression of MHC class I, II, CD80, or CD86, as assessed by flow cytometric analyses 24-hour after irradiation. The effect of irradiation on MART-1 antigen processing by DCs was evaluated using DC transduced with adenovirus MART-1 (AdVMART1). C57BL/6 mice were immunized with AdVMART1 transduced DCs, with and without prior irradiation. IFN-γ production was measured by ELISPOT assays after 10-14 days of immunization. Prior radiation treatment resulted in a significant decrease in MART-1-specific T cell responses. The ability of irradiated and non-irradiated AdVMART1/DC vaccines to protect mice against growth of murine B16 tumors, which endogenously express murine MART-1, was also examined. AdVMART1/DC vaccination protected C57BL/6 mice against challenge with viable B16 melanoma cells while DCs irradiated (10 Gy) prior to AdVMART1 transduction abrogated protection. These results suggest that proteasome inhibition in DCs by irradiation may be a possible pathway in

  10. Site Specific Waste Management Instruction for the 116-F-4 soil storage unit

    International Nuclear Information System (INIS)

    Hopkins, G.G.

    1996-08-01

    This Site Specific Waste Management Instruction provides guidance for management of waste generated during the excavation and remediation of soil and debris from the 116-4 soil storage unit located at the Hanford Site in Richland, Washington. This document outlines the waste management practices that will be performed in the field to implement federal, state, and US Department of Energy requirements

  11. Combining the GW formalism with the polarizable continuum model: A state-specific non-equilibrium approach

    Energy Technology Data Exchange (ETDEWEB)

    Duchemin, Ivan, E-mail: ivan.duchemin@cea.fr [INAC, SP2M/L-Sim, CEA/UJF Cedex 09, 38054 Grenoble (France); Jacquemin, Denis [Laboratoire CEISAM - UMR CNR 6230, Université de Nantes, 2 Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France); Institut Universitaire de France, 1 rue Descartes, 75005 Paris Cedex 5 (France); Blase, Xavier [CNRS, Inst. NÉEL, F-38000 Grenoble (France); Univ. Grenoble Alpes, Inst. NÉEL, F-38000 Grenoble (France)

    2016-04-28

    We have implemented the polarizable continuum model within the framework of the many-body Green’s function GW formalism for the calculation of electron addition and removal energies in solution. The present formalism includes both ground-state and non-equilibrium polarization effects. In addition, the polarization energies are state-specific, allowing to obtain the bath-induced renormalisation energy of all occupied and virtual energy levels. Our implementation is validated by comparisons with ΔSCF calculations performed at both the density functional theory and coupled-cluster single and double levels for solvated nucleobases. The present study opens the way to GW and Bethe-Salpeter calculations in disordered condensed phases of interest in organic optoelectronics, wet chemistry, and biology.

  12. The potential and limitations of third generation light sources

    International Nuclear Information System (INIS)

    Hormes, Josef

    2011-01-01

    To date, 3rd generation Light Sources, i.e. electron storage rings where mainly radiation from insertion devices (wigglers and undulators) is used for synchrotron radiation experiments are the 'workhorses' for basic and applied VUV/X-ray research. Several machine parameters. i.e. the energy of the electrons, the emittance and the circumference of the machine, together with the specification of the corresponding insertion devices determine the 'quality' of a facility and a specific beamline. In this talk, several of these aspects are discussed mainly from a users' point of view, i.e. what are the required specifications to carry out 'state-of-the-art' experiments in various areas, e.g. protein crystallography, Resonant Elastic and Inelastic X-ray Scattering (REIXS), Micro-/nanospectroscopy, and time resolved experiments in the femtosecond time domain. (author)

  13. Resting State Network Estimation in Individual Subjects

    Science.gov (United States)

    Hacker, Carl D.; Laumann, Timothy O.; Szrama, Nicholas P.; Baldassarre, Antonello; Snyder, Abraham Z.

    2014-01-01

    Resting-state functional magnetic resonance imaging (fMRI) has been used to study brain networks associated with both normal and pathological cognitive function. The objective of this work is to reliably compute resting state network (RSN) topography in single participants. We trained a supervised classifier (multi-layer perceptron; MLP) to associate blood oxygen level dependent (BOLD) correlation maps corresponding to pre-defined seeds with specific RSN identities. Hard classification of maps obtained from a priori seeds was highly reliable across new participants. Interestingly, continuous estimates of RSN membership retained substantial residual error. This result is consistent with the view that RSNs are hierarchically organized, and therefore not fully separable into spatially independent components. After training on a priori seed-based maps, we propagated voxel-wise correlation maps through the MLP to produce estimates of RSN membership throughout the brain. The MLP generated RSN topography estimates in individuals consistent with previous studies, even in brain regions not represented in the training data. This method could be used in future studies to relate RSN topography to other measures of functional brain organization (e.g., task-evoked responses, stimulation mapping, and deficits associated with lesions) in individuals. The multi-layer perceptron was directly compared to two alternative voxel classification procedures, specifically, dual regression and linear discriminant analysis; the perceptron generated more spatially specific RSN maps than either alternative. PMID:23735260

  14. Thinking Cap Plus Thinking Zap: tDCS of Frontopolar Cortex Improves Creative Analogical Reasoning and Facilitates Conscious Augmentation of State Creativity in Verb Generation.

    Science.gov (United States)

    Green, Adam E; Spiegel, Katherine A; Giangrande, Evan J; Weinberger, Adam B; Gallagher, Natalie M; Turkeltaub, Peter E

    2017-04-01

    Recent neuroimaging evidence indicates neural mechanisms that support transient improvements in creative performance (augmented state creativity) in response to cognitive interventions (creativity cueing). Separately, neural interventions via tDCS show encouraging potential for modulating neuronal function during creative performance. If cognitive and neural interventions are separately effective, can they be combined? Does state creativity augmentation represent "real" creativity, or do interventions simply yield divergence by diminishing meaningfulness/appropriateness? Can augmenting state creativity bolster creative reasoning that supports innovation, particularly analogical reasoning? To address these questions, we combined tDCS with creativity cueing. Testing a regionally specific hypothesis from neuroimaging, high-definition tDCS-targeted frontopolar cortex activity recently shown to predict state creativity augmentation. In a novel analogy finding task, participants under tDCS formulated substantially more creative analogical connections in a large matrix search space (creativity indexed via latent semantic analysis). Critically, increased analogical creativity was not due to diminished accuracy in discerning valid analogies, indicating "real" creativity rather than inappropriate divergence. A simpler relational creativity paradigm (modified verb generation) revealed a tDCS-by-cue interaction; tDCS further enhanced creativity cue-related increases in semantic distance. Findings point to the potential of noninvasive neuromodulation to enhance creative relational cognition, including augmentation of the deliberate effort to formulate connections between distant concepts. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. Race to the Top. Hawaii Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

    Science.gov (United States)

    US Department of Education, 2014

    2014-01-01

    This State-specific summary report serves as an assessment of Hawaii's Year 3 Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013; the Year 2 report for…

  16. State diagram of spin-torque oscillator with perpendicular reference layer and planar field generation layer

    Directory of Open Access Journals (Sweden)

    Mengwei Zhang

    2015-06-01

    Full Text Available The state diagram of spin-torque oscillator (STO with perpendicular reference layer (REF and planar field generation layer (FGL was studied by a macrospin model and a micro-magnetic model. The state diagrams are calculated versus the current density, external field and external field angle. It was found that the oscillation in FGL could be controlled by current density combined with external field so as to achieve a wide frequency range. An optimized current and applied field region was given for microwave assisted magnetic recording (MAMR, considering both frequency and output field oscillation amplitude. The results of the macro-spin model were compared with those of the micro-magnetic model. The macro-spin model was qualitatively different from micro-magnetics and experimental results when the current density was large and the FGL was non-uniform.

  17. Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States.

    Science.gov (United States)

    Coghill, Anna E; Shiels, Meredith S; Suneja, Gita; Engels, Eric A

    2015-07-20

    Despite advances in the treatment of HIV, HIV-infected people remain at increased risk for many cancers, and the number of non-AIDS-defining cancers is increasing with the aging of the HIV-infected population. No prior study has comprehensively evaluated the effect of HIV on cancer-specific mortality. We identified cases of 14 common cancers occurring from 1996 to 2010 in six US states participating in a linkage of cancer and HIV/AIDS registries. We used Cox regression to examine the association between patient HIV status and death resulting from the presenting cancer (ascertained from death certificates), adjusting for age, sex, race/ethnicity, year of cancer diagnosis, and cancer stage. We included 1,816,461 patients with cancer, 6,459 (0.36%) of whom were HIV infected. Cancer-specific mortality was significantly elevated in HIV-infected compared with HIV-uninfected patients for many cancers: colorectum (adjusted hazard ratio [HR], 1.49; 95% CI, 1.21 to 1.84), pancreas (HR, 1.71; 95% CI, 1.35 to 2.18), larynx (HR, 1.62; 95% CI, 1.06 to 2.47), lung (HR, 1.28; 95% CI, 1.17 to 1.39), melanoma (HR, 1.72; 95% CI, 1.09 to 2.70), breast (HR, 2.61; 95% CI, 2.06 to 3.31), and prostate (HR, 1.57; 95% CI, 1.02 to 2.41). HIV was not associated with increased cancer-specific mortality for anal cancer, Hodgkin lymphoma, or diffuse large B-cell lymphoma. After further adjustment for cancer treatment, HIV remained associated with elevated cancer-specific mortality for common non-AIDS-defining cancers: colorectum (HR, 1.40; 95% CI, 1.09 to 1.80), lung (HR, 1.28; 95% CI, 1.14 to 1.44), melanoma (HR, 1.93; 95% CI, 1.14 to 3.27), and breast (HR, 2.64; 95% CI, 1.86 to 3.73). HIV-infected patients with cancer experienced higher cancer-specific mortality than HIV-uninfected patients, independent of cancer stage or receipt of cancer treatment. The elevation in cancer-specific mortality among HIV-infected patients may be attributable to unmeasured stage or treatment differences as well

  18. GENESIS - The GENEric SImulation System for Modelling State Transitions.

    Science.gov (United States)

    Gillman, Matthew S

    2017-09-20

    This software implements a discrete time Markov chain model, used to model transitions between states when the transition probabilities are known a priori . It is highly configurable; the user supplies two text files, a "state transition table" and a "config file", to the Perl script genesis.pl. Given the content of these files, the script generates a set of C++ classes based on the State design pattern, and a main program, which can then be compiled and run. The C++ code generated is based on the specification in the text files. Both multiple branching and bi-directional transitions are allowed. The software has been used to model the natural histories of colorectal cancer in Mexico. Although written primarily to model such disease processes, it can be used in any process which depends on discrete states with known transition probabilities between those states. One suitable area may be in environmental modelling. A test suite is supplied with the distribution. Due to its high degree of configurability and flexibility, this software has good re-use potential. It is stored on the Figshare repository.

  19. A methodology to identify stranded generation facilities and estimate stranded costs for Louisiana's electric utility industry

    Science.gov (United States)

    Cope, Robert Frank, III

    1998-12-01

    The electric utility industry in the United States is currently experiencing a new and different type of growing pain. It is the pain of having to restructure itself into a competitive business. Many industry experts are trying to explain how the nation as a whole, as well as individual states, will implement restructuring and handle its numerous "transition problems." One significant transition problem for federal and state regulators rests with determining a utility's stranded costs. Stranded generation facilities are assets which would be uneconomic in a competitive environment or costs for assets whose regulated book value is greater than market value. At issue is the methodology which will be used to estimate stranded costs. The two primary methods are known as "Top-Down" and "Bottom-Up." The "Top-Down" approach simply determines the present value of the losses in revenue as the market price for electricity changes over a period of time into the future. The problem with this approach is that it does not take into account technical issues associated with the generation and wheeling of electricity. The "Bottom-Up" approach computes the present value of specific strandable generation facilities and compares the resulting valuations with their historical costs. It is regarded as a detailed and difficult, but more precise, approach to identifying stranded assets and their associated costs. This dissertation develops a "Bottom-Up" quantitative, optimization-based approach to electric power wheeling within the state of Louisiana. It optimally evaluates all production capabilities and coordinates the movement of bulk power through transmission interconnections of competing companies in and around the state. Sensitivity analysis to this approach is performed by varying seasonal consumer demand, electric power imports, and transmission inter-connection cost parameters. Generation facility economic dispatch and transmission interconnection bulk power transfers, specific

  20. Stimulus specificity of a steady-state visual-evoked potential-based brain-computer interface

    Science.gov (United States)

    Ng, Kian B.; Bradley, Andrew P.; Cunnington, Ross

    2012-06-01

    The mechanisms of neural excitation and inhibition when given a visual stimulus are well studied. It has been established that changing stimulus specificity such as luminance contrast or spatial frequency can alter the neuronal activity and thus modulate the visual-evoked response. In this paper, we study the effect that stimulus specificity has on the classification performance of a steady-state visual-evoked potential-based brain-computer interface (SSVEP-BCI). For example, we investigate how closely two visual stimuli can be placed before they compete for neural representation in the cortex and thus influence BCI classification accuracy. We characterize stimulus specificity using the four stimulus parameters commonly encountered in SSVEP-BCI design: temporal frequency, spatial size, number of simultaneously displayed stimuli and their spatial proximity. By varying these quantities and measuring the SSVEP-BCI classification accuracy, we are able to determine the parameters that provide optimal performance. Our results show that superior SSVEP-BCI accuracy is attained when stimuli are placed spatially more than 5° apart, with size that subtends at least 2° of visual angle, when using a tagging frequency of between high alpha and beta band. These findings may assist in deciding the stimulus parameters for optimal SSVEP-BCI design.

  1. Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Guangming Wu

    2011-07-01

    Full Text Available Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH⁻/⁻ mice as a paradigm for orphan disorders, such as hereditary metabolic liver diseases, we evaluated fibroblast-derived FAH⁻/⁻-induced pluripotent stem cells (iPS cells as targets for gene correction in combination with the tetraploid embryo complementation method. First, after characterizing the FAH⁻/⁻ iPS cell lines, we aggregated FAH⁻/⁻-iPS cells with tetraploid embryos and obtained entirely FAH⁻/⁻-iPS cell-derived mice that were viable and exhibited the phenotype of the founding FAH⁻/⁻ mice. Then, we transduced FAH cDNA into the FAH⁻/⁻-iPS cells using a third-generation lentiviral vector to generate gene-corrected iPS cells. We could not detect any chromosomal alterations in these cells by high-resolution array CGH analysis, and after their aggregation with tetraploid embryos, we obtained fully iPS cell-derived healthy mice with an astonishing high efficiency for full-term development of up to 63.3%. The gene correction was validated functionally by the long-term survival and expansion of FAH-positive cells of these mice after withdrawal of the rescuing drug NTBC (2-(2-nitro-4-fluoromethylbenzoyl-1,3-cyclohexanedione. Furthermore, our results demonstrate that both a liver-specific promoter (transthyretin, TTR-driven FAH transgene and a strong viral promoter (from spleen focus-forming virus, SFFV-driven FAH transgene rescued the FAH-deficiency phenotypes in the mice derived from the respective gene-corrected iPS cells. In conclusion, our data demonstrate that a lentiviral gene repair strategy does not abrogate the full pluripotent potential of fibroblast-derived iPS cells, and genetic manipulation of iPS cells in combination with tetraploid embryo aggregation provides a practical and rapid approach to evaluate the efficacy of gene correction of human diseases in mouse models.

  2. Generators for gearless wind energy converters

    Energy Technology Data Exchange (ETDEWEB)

    Grauers, A. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Electric Power Engineering

    1996-12-01

    This paper discusses some design alternatives for directly driven generators, and one specific generator type is investigated for a wide range of rated power. First, the specification for a directly driven generator is presented, then different design alternatives are discussed. A radial-flux permanent magnet generator for frequency converter connection has been chosen for a more detailed investigation. The design, optimization and performance of that generator type are presented. Generators from 30 kW to 3 MW are designed and compared with conventional four-pole generators with gear. It is found that a directly driven generator can be more efficient than a conventional generator and gear and have a rather small diameter and a low active weight. 8 refs, 7 figs, 2 tabs

  3. Modeling and analysis with induction generators

    CERN Document Server

    Simões, M Godoy

    2014-01-01

    ForewordPrefaceAcknowledgmentsAuthorsPrinciples of Alternative Sources of Energy and Electric GenerationScope of This ChapterLegal DefinitionsPrinciples of Electrical ConversionBasic Definitions of Electrical PowerCharacteristics of Primary SourcesCharacteristics of Remote Industrial, Commercial, and Residential Sites and Rural EnergySelection of the Electric GeneratorInterfacing Primary Source, Generator, and LoadExample of a Simple Integrated Generating and Energy-Storing SystemSolved ProblemsSuggested ProblemsReferencesSteady-State Model of Induction GeneratorsScope of This ChapterInterconnection and Disconnection of the Electric Distribution NetworkRobustness of Induction GeneratorsClassical Steady-State Representation of the Asynchronous MachineGenerated PowerInduced TorqueRepresentation of Induction Generator LossesMeasurement of Induction Generator ParametersBlocked Rotor Test (s = 1)No-Load Test (s = 0)Features of Induction Machines Working as Generators Interconnected to the Distribution NetworkHigh-...

  4. Oviduct-Specific Expression of Human Neutrophil Defensin 4 in Lentivirally Generated Transgenic Chickens

    Science.gov (United States)

    Liu, Tongxin; Wu, Hanyu; Cao, Dainan; Li, Qingyuan; Zhang, Yaqiong; Li, Ning; Hu, Xiaoxiang

    2015-01-01

    The expression of oviduct-specific recombinant proteins in transgenic chickens is a promising technology for the production of therapeutic biologics in eggs. In this study, we constructed a lentiviral vector encoding an expression cassette for human neutrophil defensin 4 (HNP4), a compound that displays high activity against Escherichia coli, and produced transgenic chickens that expressed the recombinant HNP4 protein in egg whites. After the antimicrobial activity of the recombinant HNP4 protein was tested at the cellular level, a 2.8-kb ovalbumin promoter was used to drive HNP4 expression specifically in oviduct tissues. From 669 injected eggs, 218 chickens were successfully hatched. Ten G0 roosters, with semens identified as positive for the transgene, were mated with wild-type hens to generate G1 chickens. From 1,274 total offspring, fifteen G1 transgenic chickens were positive for the transgene, which was confirmed by PCR and Southern blotting. The results of the Southern blotting and genome walking indicated that a single copy of the HNP4 gene was integrated into chromosomes 1, 2, 3, 4, 6 and 24 of the chickens. As expected, HNP4 expression was restricted to the oviduct tissues, and the levels of both transcriptional and translational HNP4 expression varied greatly in transgenic chickens with different transgene insertion sites. The amount of HNP4 protein expressed in the eggs of G1 and G2 heterozygous transgenic chickens ranged from 1.65 μg/ml to 10.18 μg/ml. These results indicated that the production of transgenic chickens that expressed HNP4 protein in egg whites was successful. PMID:26020529

  5. Potentialities of energy generation from waste and feedstock produced by the agricultural sector in Brazil: The case of the State of Paraná

    International Nuclear Information System (INIS)

    Ribeiro, Maria de Fátima dos Santos; Raiher, Augusta Pelinski

    2013-01-01

    The State of Paraná contributes significantly for the Brazilian production of sugar cane, ethanol, soybeans and pigs. In addition to the current production of ethanol, the State has a huge potential for electricity, biodiesel and biogas production. This paper presents an overview of the current situation regarding energy generation from the agricultural sector in the State, an assessment of the potentialities of energy generation from sugar cane residues and pig agricultural chains, as well as an analysis of the socioeconomic factors underlying the availability of feedstock for biodiesel production. This study has shown that it is possible to expand the energy supply in the State using residual biomass from the sugar cane and pig production. On the other side, the biodiesel production increase in the State will depend on the expansion in the consumption of products that use the cake as raw material; the increase in the feedstock availability other than canola, castor beans and sunflower; the increase of the number of family farmers as feedstock providers, so as to ensure access for biodiesel producers to the Social Fuel Stamp. - Highlights: • Potentialities of energy generation from agriculture at Paraná State were assessed. • Energy offer from the sugar cane sector will triple if residual biomass is used. • The use of pig production wastes can increase energy offer up to 103 GW h. • Paraná produces 25% of oil seeds and only 3% of the biodiesel in Brazil. • Economic factors explaining the low share of biodiesel production are pointed out

  6. A SiGe Quadrature Pulse Modulator for Superconducting Qubit State Manipulation

    Science.gov (United States)

    Kwende, Randy; Bardin, Joseph

    Manipulation of the quantum states of microwave superconducting qubits typically requires the generation of coherent modulated microwave pulses. While many off-the-shelf instruments are capable of generating such pulses, a more integrated approach is likely required if fault-tolerant quantum computing architectures are to be implemented. In this work, we present progress towards a pulse generator specifically designed to drive superconducing qubits. The device is implemented in a commercial silicon process and has been designed with energy-efficiency and scalability in mind. Pulse generation is carried out using a unique approach in which modulation is applied directly to the in-phase and quadrature components of a carrier signal in the 1-10 GHz frequency range through a unique digital-analog conversion process designed specifically for this application. The prototype pulse generator can be digitally programmed and supports sequencing of pulses with independent amplitude and phase waveforms. These amplitude and phase waveforms can be digitally programmed through a serial programming interface. Detailed performance of the pulse generator at room temperature and 4 K will be presented.

  7. Successful generation of primary virus-specific and anti-tumor T-cell responses from the naive donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells.

    NARCIS (Netherlands)

    Jedema, I.; Meent, M. van de; Pots, J.M.; Kester, M.G.; Beek, M.T. van der; Falkenburg, J.H.F.

    2011-01-01

    BACKGROUND: One of the major challenges in allogeneic stem cell transplantation is to find a balance between the harmful induction of graft-versus-host disease and the beneficial graft-versus-leukemia and pathogen-specific immune responses. Adoptive transfer of in-vitro generated donor T cells with

  8. Of paradise and clean power: The effect of California's renewable portfolio standard on in-state renewable energy generation

    Science.gov (United States)

    Yin, Clifton Lee

    Renewable portfolio standards (RPS), policies that encourage acquisition of electricity from renewable energy sources, have become popular instruments for discouraging the use of climate change inducing-fossil fuels. There has been limited research, however, that empirically evaluates their effectiveness. Using data gathered by three governmental entities -- the federal-level Energy Information Administration and two California agencies, the Employment Development Department and the Department of Finance -- this paper investigates the impact of California's RPS, one of the nation's most ambitious such policies, on in-state renewable energy generation. It finds that the California RPS did not bring about a one-time increase in generation with its inception, nor did it compel an increase in generation over time. These results raise questions as to the best way to structure RPS policies in light of growing interest in the establishment of a national RPS.

  9. BCVEGPY2.0: An upgraded version of the generator BCVEGPY with the addition of hadroproduction of the P-wave B states

    Science.gov (United States)

    Chang, Chao-Hsi; Wang, Jian-Xiong; Wu, Xing-Gang

    2006-02-01

    The generator BCVEGPY is upgraded by improving some of its features and by adding the hadroproduction of the P-wave excited B states (denoted by BcJ,L=1∗ or by hB_c and χB_c). In order to make the generator more efficient, we manipulate the amplitude as compact as possible with special effort. The correctness of the program is tested by various checks. We denote it as BCVEGPY2.0. As for the added part of the P-wave production, only the dominant gluon-gluon fusion mechanism ( gg→BcJ,L=1∗+c¯+b) is taken into account. Moreover, in the program, not only the ability to compute the contributions from the color-singlet components ( to the P-wave production but also the ability to compute the contributions from the color-octet components ( are available. With BCVEGPY2.0 the contributions from the two 'color components' to the production of each of the P-wave states may be computed separately by an option, furthermore, besides individually the event samples of the S-wave and P-wave ( cb¯)-heavy-quarkonium in various correct (realistic) mixtures can be generated by relevant options too. Program summaryTitle of program: BCVEGPY Version: 2.0 (December, 2004) Catalogue identifier: ADWQ Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWQ Program obtained from: CPC Program Library, Queen's University of Belfast, N. Ireland Reference to original program: ADTJ (BCVEGPY1.0) Reference in CPC: Comput. Phys. Comm. 159 (2004) 192 Does the new version supersede the old program: yes Computer: Any computer with FORTRAN 77 or 90 compiler. The program has been tested on HP-SC45 Sigma-X parallel computer, Linux PCs and Windows PCs with Visual Fortran Operating systems: UNIX, Linux and Windows Programming language used: FORTRAN 77/90 Memory required to execute with typical data: About 2.0 MB No. of lines in distributed program, including test data, etc.: 124 297 No. of bytes in distributed program, including test data, etc.: 1 137 177 Distribution format: tar.g2 Nature of

  10. Tidal Stream Generators, current state and potential opportunities for condition monitoring

    DEFF Research Database (Denmark)

    Kappatos, Vassilios; Georgoulas, George; Avdelidis, Nicolas

    2016-01-01

    Tidal power industry has made significant progress towards commercialization over the past decade. Significant investments from sector leaders, strong technical progress and positive media coverage have established the credibility of this specific renewable energy source. However, its progress...... is being retarded by operation and maintenance problems, which results in very low operational availability times, as low as 25 %. This paper presents a literature review of the current state of tidal device operators as well as some commercial tidal turbine condition monitoring solutions. Furthermore......, an overview is given of the global tidal activity status (tidal energy market size and geography), the key industry activity and the regulations-standards related with tidal energy industry. Therefore, the main goal of this paper is to provide a bird’s view of the current status of the tidal power industry...

  11. Renewable energy and sustainable communities: Alaska's wind generator experience†

    Directory of Open Access Journals (Sweden)

    R. Steven Konkel

    2013-08-01

    Full Text Available Background . In 1984, the Alaska Department of Commerce and Economic Development (DCED issued the State's first inventory/economic assessment of wind generators, documenting installed wind generator capacity and the economics of replacing diesel-fuel-generated electricity. Alaska's wind generation capacity had grown from hundreds of installed kilowatts to over 15.3 megawatts (MW by January 2012. Method . This article reviews data and conclusions presented in “Alaska's Wind Energy Systems; Inventory and Economic Assessment” (1. (Alaska Department of Commerce and Economic Development, S. Konkel, 1984. It provides a foundation and baseline for understanding the development of this renewable energy source. Results . Today's technologies have evolved at an astonishing pace; a typical generator in an Alaska wind farm now is likely rated at 1.5-MW capacity, compared to the single-kilowatt (kW machines present in 1984. Installed capacity has mushroomed, illustrated by Unalakleet's 600-kW wind farm dwarfing the original three 10-kW machines included in the 1984 inventory. Kodiak Electric had three 1.5-MW turbines installed at Pillar Mountain in 2009, with three additional turbines of 4.5-MW capacity installed in 2012. Utilities now actively plan for wind generation and compete for state funding. Discussion . State of Alaska energy policy provides the context for energy project decision-making. Substantial renewable energy fund (REF awards – $202,000,000 to date for 227 REF projects in the first 5 cycles of funding – along with numerous energy conservation programs – are now in place. Increasing investment in wind is driven by multiple factors. Stakeholders have interests both in public policy and meeting private investment objectives. Wind generator investors should consider project economics and potential impacts of energy decisions on human health. Specifically this article considers: a. changing environmental conditions in remote Alaska

  12. Mood, anxiety, and personality disorders among first and second-generation immigrants to the United States

    Science.gov (United States)

    Salas-Wright, Christopher P.; Kagotho, Njeri; Vaughn, Michael G.

    2014-01-01

    A careful examination of the multigenerational relationship between immigrant status and mental disorders can provide important information about the robustness and nature of the immigrant-mental health link. We examine immigrant status as a protective factor against mental illness, assess intergenerational effects, examine differences across race/ethnicity, and report the prevalence of mood, anxiety, and personality disorders of immigrants across major world regions. We employ data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and compare first (n = 5,363) and second-generation (n = 4826) immigrants from Asia, Africa, Europe, and Latin America to native-born Americans (n = 24,461) with respect to mental disorders. First-generation immigrants are significantly less likely than native-born Americans to be diagnosed with a mood, anxiety, or personality disorder, though the prevalence of mental health diagnoses increases among second generation immigrants. Similar results were observed for immigrants from major world regions as the prevalence of psychiatric morbidity was lower among immigrants from Africa, Latin America, Europe, and Asia compared to native-born Americans. Findings provide evidence in support of the notion that the immigrant paradox may be extended to include mood, anxiety, and personality disorders in the United States. PMID:25223256

  13. Climate change/variability science and adaptive strategies for state and regional transportation decision making.

    Science.gov (United States)

    2010-04-01

    The objective of this study was to generate a baseline understanding of current policy responses to climate : change/variability at the state and regional transportation-planning and -decision levels. Specifically, : researchers were interested in th...

  14. Laboratory generation of gravitational waves

    International Nuclear Information System (INIS)

    Pinto, I.M.; Rotoli, G.

    1988-01-01

    The authors have performed calculations on the basic type of gravitational wave electromagnetic laboratory generators. Their results show that laboratory generations of gravitational wave is at limit of state-of-the-art of present-day giant electromagnetic field generation

  15. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance.

    Science.gov (United States)

    Kamomae, Takeshi; Shimizu, Hidetoshi; Nakaya, Takayoshi; Okudaira, Kuniyasu; Aoyama, Takahiro; Oguchi, Hiroshi; Komori, Masataka; Kawamura, Mariko; Ohtakara, Kazuhiro; Monzen, Hajime; Itoh, Yoshiyuki; Naganawa, Shinji

    2017-12-01

    Pretreatment intensity-modulated radiotherapy quality assurance is performed using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we construct a system for generating patient-specific three-dimensional (3D)-printed phantoms for radiotherapy dosimetry. An anthropomorphic head phantom containing the bone and hollow of the paranasal sinus is scanned by computed tomography (CT). Based on surface rendering data, a patient-specific phantom is formed using a fused-deposition-modeling-based 3D printer, with a polylactic acid filament as the printing material. Radiophotoluminescence glass dosimeters can be inserted in the 3D-printed phantom. The phantom shape, CT value, and absorbed doses are compared between the actual and 3D-printed phantoms. The shape difference between the actual and printed phantoms is less than 1 mm except in the bottom surface region. The average CT value of the infill region in the 3D-printed phantom is -6 ± 18 Hounsfield units (HU) and that of the vertical shell region is 126 ± 18 HU. When the same plans were irradiated, the dose differences were generally less than 2%. These results demonstrate the feasibility of the 3D-printed phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  16. Development of Specifications for Radioactive Waste Packages

    International Nuclear Information System (INIS)

    2006-10-01

    The main objective of this publication is to provide guidelines for the development of waste package specifications that comply with waste acceptance requirements for storage and disposal of radioactive waste. It will assist waste generators and waste package producers in selecting the most significant parameters and in developing and implementing specifications for each individual type of waste and waste package. This publication also identifies and reviews the activities and technical provisions that are necessary to meet safety requirements; in particular, selection of the significant safety parameters and preparation of specifications for waste forms, waste containers and waste packages using proven approaches, methods and technologies. This report provides guidance using a systematic, stepwise approach, integrating the technical, organizational and administrative factors that need to be considered at each step of planning and implementing waste package design, fabrication, approval, quality assurance and control. The report reflects the considerable experience and knowledge that has been accumulated in the IAEA Member States and is consistent with the current international requirements, principles, standards and guidance for the safe management of radioactive waste

  17. Development of Specifications for Radioactive Waste Packages

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-10-15

    The main objective of this publication is to provide guidelines for the development of waste package specifications that comply with waste acceptance requirements for storage and disposal of radioactive waste. It will assist waste generators and waste package producers in selecting the most significant parameters and in developing and implementing specifications for each individual type of waste and waste package. This publication also identifies and reviews the activities and technical provisions that are necessary to meet safety requirements; in particular, selection of the significant safety parameters and preparation of specifications for waste forms, waste containers and waste packages using proven approaches, methods and technologies. This report provides guidance using a systematic, stepwise approach, integrating the technical, organizational and administrative factors that need to be considered at each step of planning and implementing waste package design, fabrication, approval, quality assurance and control. The report reflects the considerable experience and knowledge that has been accumulated in the IAEA Member States and is consistent with the current international requirements, principles, standards and guidance for the safe management of radioactive waste.

  18. Next generation toroidal devices

    International Nuclear Information System (INIS)

    Yoshikawa, Shoichi

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  19. Next generation toroidal devices

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  20. Increasing coal-fired power generation efficiency to reduce electric cost and environmental emissions

    International Nuclear Information System (INIS)

    Torrens, I.M.; Stenzel, W.C.

    1997-01-01

    New generating capacity required globally between 1993 and 2010 is estimated to be around 1500 GW, of which some two-thirds will be outside the OECD, and some 40 % in the Asian non-OECD countries. Coal is likely to account for a substantial fraction of this new generation. Today's state-of-the-art supercritical coal-fired power plant has a conversion efficiency of some 42-45 %. The capital cost increase associated with the supercritical or ultra-supercritical pulverized coal power plant compared to a conventional subcritical plant is small to negligible. The increased efficiency associated with the supercritical plant leads to an actual reduction in the total cost of electricity generated in cents/kWh, relative to a conventional plant. Despite this, the power sector continues to build subcritical plants and has no near term plans to increase the efficiency of power plants in the projects it is developing. Advanced clean coal technologies such as integrated gasification combined cycle and pressurized fluidized bed combustion will be selected for independent power projects only in very specific circumstances. Advanced clean coal plants can be operated reliably and with superior performance, and specifically that their present estimated capital costs can be reduced substantially to a point where they are competitive with state-of-the-art pulverized coal technologies. (R.P.)