WorldWideScience

Sample records for state dependent current

  1. When can time-dependent currents be reproduced by the Landauer steady-state approximation?

    Science.gov (United States)

    Carey, Rachel; Chen, Liping; Gu, Bing; Franco, Ignacio

    2017-05-07

    We establish well-defined limits in which the time-dependent electronic currents across a molecular junction subject to a fluctuating environment can be quantitatively captured via the Landauer steady-state approximation. For this, we calculate the exact time-dependent non-equilibrium Green's function (TD-NEGF) current along a model two-site molecular junction, in which the site energies are subject to correlated noise, and contrast it with that obtained from the Landauer approach. The ability of the steady-state approximation to capture the TD-NEGF behavior at each instant of time is quantified via the same-time correlation function of the currents obtained from the two methods, while their global agreement is quantified by examining differences in the average currents. The Landauer steady-state approach is found to be a useful approximation when (i) the fluctuations do not disrupt the degree of delocalization of the molecular eigenstates responsible for transport and (ii) the characteristic time for charge exchange between the molecule and leads is fast with respect to the molecular correlation time. For resonant transport, when these conditions are satisfied, the Landauer approach is found to accurately describe the current, both on average and at each instant of time. For non-resonant transport, we find that while the steady-state approach fails to capture the time-dependent transport at each instant of time, it still provides a good approximation to the average currents. These criteria can be employed to adopt effective modeling strategies for transport through molecular junctions in interaction with a fluctuating environment, as is necessary to describe experiments.

  2. State Dependence in Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    2014-01-01

    This study examines the extent state dependence among unemployed immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between...... the unobserved individual heterogeneity and the initial condition and that the degree of state dependence is overstated if we do not address this problem. The results show that an individual who was unemployed at period “t-1” has 6.5 percentage points higher probability of being unemployed again at period t...

  3. State Dependence in Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    2014-01-01

    This study examines the extent state dependence among unemployed immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between the un...

  4. A teoria da dependência à luz da realidade atual (The dependency theory in the light of the current state of affairs

    Directory of Open Access Journals (Sweden)

    Valdenesio Aduci Mendes

    2010-01-01

    Full Text Available Resumo: Este trabalho visa apresentar os alcances e limites da teoria da dependência, delineada a partir de 1970, como proposta de leitura da realidade econômica do continente latino-americano. Procuraremos mostrar que a teoria da dependência está vinculada às ideias mestras da teoria do desenvolvimento da CEPAL. Nesse sentido, os alcances da teoria da dependência, se comparada com a teoria do desenvolvimento, estão vinculados à ideia de que a situação de subdesenvolvimento no continente latino-americano se relaciona com o mundo da economia e da política. Por outro lado, os limites da teoria da dependência radicam no fato de que ela não cumpriu com sua proposta inicial, pois sua leitura da realidade latinoamericana ficou restrita a aspectos econômicos. A análise parte do pressuposto de que a crise da modernidade se dá em todos os aspectos da vida ocidental, fruto da racionalidade econômica e do desenvolvimento unidimensional, o que atinge a região latino-americana diretamente. Assim, tanto a compreensão da realidade que nos circunda, assim como a sua transformação, exigem que se repense o modelo de homogeneização do padrão de produção e de consumo, vigentes na sociedade latino-americana, cuja matriz é o modelo ocidental dos países do centro.Abstract: This work aims at presenting the range and the limits of the dependence theory, fi rst outlined in 1970, as a means of analyzing the economic reality of the Latin American continent. The objective of the following article is to demonstrate that the dependence theory is closely related to the ideas behind the CEPAL’s development theory. In this sense, the range of the dependence theory, when compared to the development theory, is bound to the idea that the underdevelopment state of the Latin American continent is linked to the economic and political worlds. On the other hand, the limits of the dependence theory are based on the fact that it hasn’t accomplished its

  5. Radiopharmaceuticals - current state and trends

    International Nuclear Information System (INIS)

    Muenze, R.

    1981-07-01

    The current state as well as the tendencies of modern radiopharmaceutical development and application is reviewed. After an evaluation of the fundamental preconditions of decay characteristics and pharmaceutical properties the problems concerning sup(99m)Tc-radiopharmaceuticals, metabolizable compounds and the use of specific biological interactions are discussed. (author)

  6. State-Dependent Molecular Dynamics

    Directory of Open Access Journals (Sweden)

    Ciann-Dong Yang

    2014-10-01

    Full Text Available This paper proposes a new mixed quantum mechanics (QM—molecular mechanics (MM approach, where MM is replaced by quantum Hamilton mechanics (QHM, which inherits the modeling capability of MM, while preserving the state-dependent nature of QM. QHM, a single mechanics playing the roles of QM and MM simultaneously, will be employed here to derive the three-dimensional quantum dynamics of diatomic molecules. The resulting state-dependent molecular dynamics including vibration, rotation and spin are shown to completely agree with the QM description and well match the experimental vibration-rotation spectrum. QHM can be incorporated into the framework of a mixed quantum-classical Bohmian method to enable a trajectory interpretation of orbital-spin interaction and spin entanglement in molecular dynamics.

  7. State-dependent molecular dynamics.

    Science.gov (United States)

    Yang, Ciann-Dong; Weng, Hung-Jen

    2014-10-09

    This paper proposes a new mixed quantum mechanics (QM)-molecular mechanics (MM) approach, where MM is replaced by quantum Hamilton mechanics (QHM), which inherits the modeling capability of MM, while preserving the state-dependent nature of QM. QHM, a single mechanics playing the roles of QM and MM simultaneously, will be employed here to derive the three-dimensional quantum dynamics of diatomic molecules. The resulting state-dependent molecular dynamics including vibration, rotation and spin are shown to completely agree with the QM description and well match the experimental vibration-rotation spectrum. QHM can be incorporated into the framework of a mixed quantum-classical Bohmian method to enable a trajectory interpretation of orbital-spin interaction and spin entanglement in molecular dynamics.

  8. State-dependent visual processing

    Directory of Open Access Journals (Sweden)

    Juliane eBritz

    2011-12-01

    Full Text Available The temporal dynamics and anatomical correlates underlying human visual cognition are traditionally assessed as a function of stimulus properties and task demands. Any non-stimulus related activity is commonly dismissed as noise and eliminated to extract an evoked signal that is only a small fraction of the magnitude of the measured signal. We review studies that challenge this view by showing that non-stimulus related activity is not mere noise but that it has a well structured organization which can largely determine the processing of upcoming stimuli. We review evidence from human electrophysiology that shows how different aspects of pre-stimulus activity such as pre-stimulus EEG frequency power and phase and pre-stimulus EEG microstates can determine qualitative and quantitative properties of both lower and higher level visual processing. These studies show that low-level sensory processes depend on the momentary excitability of sensory cortices whereas perceptual processes leading to stimulus awareness depend on momentary pre-stimulus activity in higher-level non-visual brain areas. Speed and accuracy of stimulus identification have likewise been shown to be modulated by pre-stimulus brain states.

  9. State-dependent visual processing.

    Science.gov (United States)

    Britz, Juliane; Michel, Christoph M

    2011-01-01

    The temporal dynamics and anatomical correlates underlying human visual cognition are traditionally assessed as a function of stimulus properties and task demands. Any non-stimulus related activity is commonly dismissed as noise and eliminated to extract an evoked signal that is only a small fraction of the magnitude of the measured signal. We review studies that challenge this view by showing that non-stimulus related activity is not mere noise but that it has a well-structured organization which can largely determine the processing of upcoming stimuli. We review recent evidence from human electrophysiology that shows how different aspects of pre-stimulus activity such as pre-stimulus EEG frequency power and phase and pre-stimulus EEG microstates can determine qualitative and quantitative properties of both lower and higher-level visual processing. These studies show that low-level sensory processes depend on the momentary excitability of sensory cortices whereas perceptual processes leading to stimulus awareness depend on momentary pre-stimulus activity in higher-level non-visual brain areas. Also speed and accuracy of stimulus identification have likewise been shown to be modulated by pre-stimulus brain states.

  10. UROGENITAL CHLAMYDIOSIS: CURRENT STATE (REVIEW

    Directory of Open Access Journals (Sweden)

    T. A. Volodina

    2014-01-01

    Full Text Available Today, infectious diseases of urogenital tract are the reason of the whole range of pathological states. Despite the successes of scientific society in the development of contemporary methods for diagnosis and treatment of sexually transmissive infections their prevalence rate is still high. The review covers the most frequent bacterial sexually transmissive infection chlamydiosis, its prevalence rate and treatment methods

  11. [Drugs, a current problem. Alcohol dependency].

    Science.gov (United States)

    Amigó Tadín, Montserrat

    2006-01-01

    Alcohol is a socially accepted drug which is commercialized in multiple products including wine, cognac, gin, beer, anisette, vermouth, rum, etc. and which can be consumed in small quantities without producing harmful effects on one's health; nonetheless, women are more susceptible to alcohol's damages and an abusive consumption of alcohol creates dependence and chronic diseases. Ten percent of those people who consume alcohol develop dependency and comprise the leading group of drug addicts in many countries.

  12. Elections, Information, and State-Dependent Candidate Quality

    DEFF Research Database (Denmark)

    Jensen, Thomas

    The quality of political candidates often depends on the current state of the world, for example because their personal characteristics are more valuable in some situations than in others. We explore the implications of state-dependent candidate quality in a model of electoral competition where...

  13. Delay Discounting in Current and Former Marijuana-Dependent Individuals

    OpenAIRE

    Johnson, Matthew W.; Bickel, Warren K.; Baker, Forest; Moore, Brent A.; Badger, Gary J.; Budney, Alan J.

    2010-01-01

    Studies have found that a variety of drug dependent groups discount delayed rewards more than matched-controls. This study compared delay discounting for a hypothetical $1000 reward among dependent marijuana users, former dependent marijuana users, and matched-controls. Discounting of marijuana was also assessed in the currently marijuana-dependent group. No significant difference in discounting was detected among the groups, however currently dependent users showed a trend to discount money ...

  14. Current State of Dental Education: Executive Summary.

    Science.gov (United States)

    Formicola, Allan J

    2017-08-01

    This executive summary for Section 1 of the "Advancing Dental Education in the 21 st Century" project provides a composite picture of information from 12 background articles on the current state of dental education in the United States. The summary includes the following topics: the current status of the dental curriculum, the implications of student debt and dental school finances, the expansion of enrollment, student diversity, pre- and postdoctoral education, safety net status of dental school clinics, and trends in faculty.

  15. Strategies for state-dependent quantum deleting

    International Nuclear Information System (INIS)

    Song Wei; Yang Ming; Cao Zhuoliang

    2004-01-01

    A quantum state-dependent quantum deleting machine is constructed. We obtain a upper bound of the global fidelity on N-to-M quantum deleting from a set of K non-orthogonal states. Quantum networks are constructed for the above state-dependent quantum deleting machine when K=2. Our deleting protocol only involves a unitary interaction among the initial copies, with no ancilla. We also present some analogies between quantum cloning and deleting

  16. Experimental study of the dependence of beam current on injection ...

    Indian Academy of Sciences (India)

    The ion current from an electron cyclotron resonance (ECR) heavy ion source depends on the confining axial and radial magnetic fields. Some efforts were made by earlier workers to investigate magnetic field scaling on the performance of the ECR source. In order to study the dependence of the ion current on the injection ...

  17. Experimental study of the dependence of beam current on injection ...

    Indian Academy of Sciences (India)

    Abstract. The ion current from an electron cyclotron resonance (ECR) heavy ion source depends on the confining axial and radial magnetic fields. Some efforts were made by earlier workers to investigate magnetic field scaling on the performance of the ECR source. In order to study the dependence of the ion current on the ...

  18. State Emergency Department Opioid Guidelines: Current Status.

    Science.gov (United States)

    Broida, Robert I; Gronowski, Tanner; Kalnow, Andrew F; Little, Andrew G; Lloyd, Christopher M

    2017-04-01

    The purpose of this study was to evaluate and categorize current state-sponsored opioid guidelines for the practice of emergency medicine (EM). We conducted a comprehensive search of EM-specific opioid prescribing guidelines and/or policies in each state to determine current state involvement in EM opioid prescribing, as well as to evaluate some of the specifics of each guideline or policy. The search was conducted using an online query and a follow-up email request to each state chapter of ACEP. We found that 17 states had emergency department-specific guidelines. We further organized the guidelines into four categories: limiting prescriptions for opioids with 67 total recommendations; preventing/diverting abuse with 56 total recommendations; addiction-related guidelines with 29 total recommendations; and a community resources section with 24 total recommendations. Our results showed that current state guidelines focus on providers limiting opioid pain prescriptions and vetting patients for possible abuse/diversion. This study highlights the 17 states that have addressed opioid prescribing guidelines and categorizes their efforts to date. It is hoped that this study will provide the basis for similar efforts in other states.

  19. Current State of Craniofacial Prosthetic Rehabilitation

    NARCIS (Netherlands)

    Ariani, Nina; Visser, Anita; van Oort, Robert P.; Kusdhany, Lindawati; Rahardjo, Tri Budi W.; Krom, Bastiaan P.; van der Mei, Henny C.; Vissink, Arjan

    2013-01-01

    Purpose: This study aimed to review the current state of the techniques and materials used to rehabilitate maxillofacial defects. Materials and Methods: The MEDLINE and EMBASE databases were searched for articles pertinent to maxillofacial prostheses published from January 1990 to July 2011. The

  20. Voltage Dependence of a Neuromodulator-Activated Ionic Current123

    Science.gov (United States)

    2016-01-01

    Abstract The neuromodulatory inward current (IMI) generated by crab Cancer borealis stomatogastric ganglion neurons is an inward current whose voltage dependence has been shown to be crucial in the activation of oscillatory activity of the pyloric network of this system. It has been previously shown that IMI loses its voltage dependence in conditions of low extracellular calcium, but that this effect appears to be regulated by intracellular calmodulin. Voltage dependence is only rarely regulated by intracellular signaling mechanisms. Here we address the hypothesis that the voltage dependence of IMI is mediated by intracellular signaling pathways activated by extracellular calcium. We demonstrate that calmodulin inhibitors and a ryanodine antagonist can reduce IMI voltage dependence in normal Ca2+, but that, in conditions of low Ca2+, calmodulin activators do not restore IMI voltage dependence. Further, we show evidence that CaMKII alters IMI voltage dependence. These results suggest that calmodulin is necessary but not sufficient for IMI voltage dependence. We therefore hypothesize that the Ca2+/calmodulin requirement for IMI voltage dependence is due to an active sensing of extracellular calcium by a GPCR family calcium-sensing receptor (CaSR) and that the reduction in IMI voltage dependence by a calmodulin inhibitor is due to CaSR endocytosis. Supporting this, preincubation with an endocytosis inhibitor prevented W7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride)-induced loss of IMI voltage dependence, and a CaSR antagonist reduced IMI voltage dependence. Additionally, myosin light chain kinase, which is known to act downstream of the CaSR, seems to play a role in regulating IMI voltage dependence. Finally, a Gβγ-subunit inhibitor also affects IMI voltage dependence, in support of the hypothesis that this process is regulated by a G-protein-coupled CaSR. PMID:27257619

  1. State Dependence in Unemployment among Danish Immigrants

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    2009-01-01

    This study examines the extent state dependence among unemployed Danish immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between...

  2. Seasonal dependence of large-scale Birkeland currents

    International Nuclear Information System (INIS)

    Fujii, R.; Iijima, T.; Potemra, T.A.; Sugiura, M.

    1981-01-01

    The seasonal dependence of large-scale Birkeland currents has been determined from the analysis of vector magnetic field data acquired by the TRIAD satellite in the northern hemisphere. Statistical characteristics of single sheet (i.e., net currents) and double sheet Birkeland currents were determined from 555 TRIAD passes during the summer, and 408 passes during the winter (more complicated multiple-sheet current systems were not included in this study). The average K/sub p/ value for the summer events is 1.9 and for the winter events is 2.0. The principal results include the following: (1) The single sheet Birkeland currents are statistically observed more often than the double sheet currents in the dayside of the auroral zone during any season. The single sheet currents are also observed more often in the summer than in the winter (as much as 2 to 3 times as often depending upon the MLT sector). (2) The intensities of the single and double sheet Birkeland currents on the dayside, from approximately 1000 MLT to 1800 MLT, are larger during the summer (in comparison to winter) by a factor of about 2. (3) The intensities of the double sheet Birkeland currents in the nightside (the dominant system in this local time) do not show a significant difference from summer to winter. (4) The single and double sheet currents in the dayside (between 0600 and 1800 MLT) appear at higher latitudes (by about 1 0 to 3 0 ) during the summer in comparison to the winter. These characterisctis suggest that the Birkeland current intensities are controlled by the ionosphere conductivity in the polar region. The greater occurrence of single sheet Birkeland currents during the summertime supports the suggestion that these currents close via the polar cap when the conductivity there is sufficiently high to permit it

  3. Low noise constant current source for bias dependent noise measurements

    Energy Technology Data Exchange (ETDEWEB)

    Talukdar, D.; Bose, Suvendu; Bardhan, K. K. [Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064 (India); Chakraborty, R. K. [Bidhannagar College, EB - 2, Bidhannagar, Kolkata 700064 (India)

    2011-01-15

    A low noise constant current source used for measuring the 1/f noise in disordered systems in ohmic as well as nonohmic regime is described. The source can supply low noise constant current starting from as low as 1 {mu}A to a few tens of milliampere with a high voltage compliance limit of around 20 V. The constant current source has several stages, which can work in a standalone manner or together to supply the desired value of load current. The noise contributed by the current source is very low in the entire current range. The fabrication of a low noise voltage preamplifier modified for bias dependent noise measurements and based on the existing design available in the MAT04 data sheet is also described.

  4. Beam position dependence of a wall-current monitor

    International Nuclear Information System (INIS)

    Tamiya, K.; Asami, A.; Suwada, T.; Urano, T.; Kobayashi, H.

    1995-01-01

    It was pointed out recently that there exists an appreciable beam position dependence in the wall-current monitor widely used in electron accelerators. Detailed study of this dependence is performed on a test bench varying the pulse width and the frequency of the input signal simulating the beam. The results of experiments show that when the pulse width becomes shorter more appreciable becomes the dependence, and it approaches to that of calculated from the method of images. A unified analysis is under way. (author)

  5. The Current State of Teleophthalmology in the United States.

    Science.gov (United States)

    Rathi, Siddarth; Tsui, Edmund; Mehta, Nitish; Zahid, Sarwar; Schuman, Joel S

    2017-12-01

    Telemedicine services facilitate the evaluation, diagnosis, and management of the remote patient. Telemedicine has rapidly flourished in the United States and has improved access to care, outcomes, and patient satisfaction. However, the use of telemedicine in ophthalmology is currently in its infancy and has yet to gain wide acceptance. Current models of telemedicine in ophthalmology are largely performed via "store and forward" methods, but remote monitoring and interactive modalities exist. Although studies have examined the effects of telemedicine, few reports have characterized its current status. We perform a descriptive analysis of the current state of teleophthalmology in the United States. We describe the use of teleophthalmology in the hospital and outpatient settings. We also review the applications to retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and glaucoma, as well as anticipated barriers and hurdles for the future adoption of teleophthalmology. With ongoing advances in teleophthalmology, these models may provide earlier detection and more reliable monitoring of vision-threatening diseases. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  6. The United States facing their petroleum dependence

    International Nuclear Information System (INIS)

    Noel, P.

    2002-06-01

    In the framework of ''the energy crisis of 2000-2001'', the Cheney report and the petroleum dependence, this study presents a critical examination of the United States petroleum situation, its perception in the american political milieu and the public policies implementing during the last ten years. The first section is devoted to the petroleum supply. In the second section, the american petroleum policy and the energy safety are studied. (A.L.B.)

  7. State Dependence in Unemployment among Danish Immigrants

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    This study examines the extent state dependence among unemployed Danish immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between...... compared to an individual who was employed at period "t-1". This average partial effect is the same for western compared to non-western immigrants and women compared to men....

  8. [Male contraception - the current state of knowledge].

    Science.gov (United States)

    Zdrojewicz, Zygmynt; Kasperska, Karolina; Lewandowska, Marta

    2016-08-01

    Contraception is important from a health, psychological and socioeconomic point of view. Due to the fact that male-based contraceptive methods are mostly represented by condoms and vasectomy, researchers are working on the new solutions, which could let the men be more involved in a conscious family planning. In this review we will present the current state of knowledge on this subject. There is a lot going on in the field of hormonal contraception. Studies including testosterone, progestins, synthetic androgens and other derivatives are on a different stages of clinical trials and mostly demonstrate high efficacy rates. Recent discovers of Izumo and Juno proteins, essential for the fertilization process, give hope for an easily reversible, non-hormonal method. Researchers are also trying to interfere with the process of spermatogenesis using BRDT inhibitor - JQ1, or neutralize the sperm by injecting styrene maleic anhydride (SMA) into the lumen of the vas deferens. The other studies explore processes involved in proper sperm motility. A vaccine which induces an immune response to the reproductive system is also an interesting method. The latest research use ultrasound waves and mechanical device which blocks the patency of vas deferens. The aim of the study current state of knowledge male contraception. © 2016 MEDPRESS.

  9. RETAIL BANKING BUSINESS: CURRENT STATE ANDSPECIFIC FEATURES

    Directory of Open Access Journals (Sweden)

    Гузель Рефкадовна Фаизова

    2013-04-01

    Full Text Available The role and importance of the retail banking business in the banking sector continueto grow. The current state of the retail banking business is considered and specific features of this area in the face of growing demand for banking products and services by the public and interest from lending institutions are identified by the article.Purpose: Research of current state of retail banking business and detection specific features of this area.Methodology: In the process of analysis and researchof the question the methods of economical and statistical analysis, methods of comparison and generalizationwereused.Results: The conclusion is that interest in the retail banking business continues to grow.There were revealed the role and the importance of standardized service processes and standardized products and services delivering as one of the main line of development in the segment of retail business.DOI: http://dx.doi.org/10.12731/2218-7405-2013-3-2

  10. Calcium dependent current recordings in Xenopus laevis oocytes in microgravity

    Science.gov (United States)

    Wuest, Simon L.; Roesch, Christian; Ille, Fabian; Egli, Marcel

    2017-12-01

    Mechanical unloading by microgravity (or weightlessness) conditions triggers profound adaptation processes at the cellular and organ levels. Among other mechanisms, mechanosensitive ion channels are thought to play a key role in allowing cells to transduce mechanical forces. Previous experiments performed under microgravity have shown that gravity affects the gating properties of ion channels. Here, a method is described to record a calcium-dependent current in native Xenopus laevis oocytes under microgravity conditions during a parabolic flight. A 3-voltage-step protocol was applied to provoke a calcium-dependent current. This current increased with extracellular calcium concentration and could be reduced by applying extracellular gadolinium. The custom-made ;OoClamp; hardware was validated by comparing the results of the 3-voltage-step protocol to results obtained with a well-established two-electrode voltage clamp (TEVC). In the context of the 2nd Swiss Parabolic Flight Campaign, we tested the OoClamp and the method. The setup and experiment protocol worked well in parabolic flight. A tendency that the calcium-dependent current was smaller under microgravity than under 1 g condition could be observed. However, a conclusive statement was not possible due to the small size of the data base that could be gathered.

  11. Current state of craniofacial prosthetic rehabilitation.

    Science.gov (United States)

    Ariani, Nina; Visser, Anita; van Oort, Robert P; Kusdhany, Lindawati; Rahardjo, Tri Budi W; Krom, Bastiaan P; van der Mei, Henry C; Vissink, Arjan

    2013-01-01

    This study aimed to review the current state of the techniques and materials used to rehabilitate maxillofacial defects. The MEDLINE and EMBASE databases were searched for articles pertinent to maxillofacial prostheses published from January 1990 to July 2011. The main clinical stages were the subject of analysis. A multidisciplinary approach is preferred when rehabilitating maxillofacial defects. Surgical reconstruction can be used for smaller defects, but larger defects require a prosthesis to achieve an esthetic rehabilitation. Implant retained prostheses are preferred over adhesive prostheses. Silicone elastomer is currently the best material available for maxillofacial prostheses; however, longevity and discoloration, which are greatly influenced by ultraviolet radiation, microorganisms, and environmental factors, remain significant problems. In the near future, the widespread availability and cost effectiveness of digital systems may improve the workflow and outcomes of facial prostheses. Patients report high satisfaction with their prostheses despite some areas that still need improvement. Maxillofacial prostheses are a reliable treatment option to restore maxillofacial defects and improve quality of life. Significant progress has been made in the application of implants for retention and digital technology for designing surgical guides, suprastructures, and craniofacial prostheses. Further improvements are necessary to enhance longevity of prostheses.

  12. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents

    DEFF Research Database (Denmark)

    Patel, Bijal; Bright, Damian P; Mortensen, Martin

    2016-01-01

    of neurological disorders. Consequently, developing compounds to selectively modulate the activity of extrasynaptic GABAA receptors underlying tonic inhibition is likely to prove therapeutically useful. Here, we examine the GABAA receptor subtype selectivity of the weak partial agonist, 5-(4-piperidyl)isoxazol-3......-ol (4-PIOL), as a potential mechanism for modulating extrasynaptic GABAA receptor-mediated tonic currents. By using recombinant GABAA receptors expressed in HEK293 cells, and native GABAA receptors of cerebellar granule cells, hippocampal neurons, and thalamic relay neurons, 4-PIOL evidently...... displayed differential agonist and antagonist-type profiles, depending on the extrasynaptic GABAA receptor isoforms targeted. For neurons, this resulted in differential modulation of GABA tonic currents, depending on the cell type studied, their respective GABAA receptor subunit compositions, and critically...

  13. The Current State of Music Therapy Theory?

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2015-01-01

    An essay on themes from Ken Aigen (2014): "The Study of Music Therapy. Current Issues and Concepts"......An essay on themes from Ken Aigen (2014): "The Study of Music Therapy. Current Issues and Concepts"...

  14. Current state of sewage treatment in China.

    Science.gov (United States)

    Jin, Lingyun; Zhang, Guangming; Tian, Huifang

    2014-12-01

    The study reported and analyzed the current state of wastewater treatment plants (WWTPs) in urban China from the aspects of scale, treatment processes, sludge handling, geographical distribution, and discharge standards. By 2012, there were 3340 WWTPs in operation in China with a capacity of 1.42 × 10(8) m(3)/d. The number of medium-scale WWTPs (1-10 × 10(4) m(3)/d) counted for 75% of total WWTPs. On average, the chemical oxygen demand (COD) removal efficiencies of small-scale, medium-scale, large-scale and super-large-scale WWTPs were 81, 85.5, 87.5 and 86.5%, respectively. Generally speaking, the nutrients removal instead of COD removal was of concern. As to the different processes, oxidation ditch, anaerobic-anoxic-oxic (A(2)/O) and sequencing batch reactor (SBR) were the mainstream technologies in China. These technologies had minor difference in terms of overall COD removal efficiency. The sludge treatment in WWTPs was basically "thickening-coagulation-mechanical dehydration" and the major disposal method was sanitary landfill in China. The distributions of WWTPs and their utilization showed significant regional characteristics. The sewage treatment capacity of China concentrated on the coastal areas and middle reaches of Yangtze River, which were the economically developed zones. Besides, most WWTPs enforced the Class 1 or Class 2 discharge standards, but few realized wastewater reuse. Finally, existing problems were discussed, including low removal efficiency of nitrogen and phosphorus, emerging contaminants, low reuse of reclaimed water, poor sludge treatment and disposal, low execution standard of effluent, and emissions of greenhouse gas from WWTPs. Suggestions regarding potential technical and administrative measures were given. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Six types Monte Carlo for estimating the current unavailability of Markov system with dependent repair

    International Nuclear Information System (INIS)

    Xiao Gang; Li Zhizhong

    2004-01-01

    Based on integral equaiton describing the life-history of Markov system, six types of estimators of the current unavailability of Markov system with dependent repair are propounded. Combining with the biased sampling of state transition time of system, six types of Monte Carlo for estimating the current unavailability are given. Two numerical examples are given to deal with the variances and efficiencies of the six types of Monte Carlo methods. (authors)

  16. Time-dependent current into and through multilevel parallel quantum dots in a photon cavity

    Science.gov (United States)

    Gudmundsson, Vidar; Abdullah, Nzar Rauf; Sitek, Anna; Goan, Hsi-Sheng; Tang, Chi-Shung; Manolescu, Andrei

    2017-05-01

    We analyze theoretically the charging current into, and the transport current through, a nanoscale two-dimensional electron system with two parallel quantum dots embedded in a short wire placed in a photon cavity. A plunger gate is used to place specific many-body states of the interacting system in the bias window defined by the external leads. We show how the transport phenomena active in the many-level complex central system strongly depend on the gate voltage. We identify a resonant transport through the central system as the two spin components of the one-electron ground state are in the bias window. This resonant transport through the lowest energy electron states seems to a large extent independent of the detuned photon field when judged from the transport current. This could be expected in the small bias regime, but an observation of the occupancy of the states of the system reveals that this picture is not entirely true. The current does not reflect slower photon-active internal transitions bringing the system into the steady state. The number of initially present photons determines when the system reaches the real steady state. With two-electron states in the bias window we observe a more complex situation with intermediate radiative and nonradiative relaxation channels leading to a steady state with a weak nonresonant current caused by inelastic tunneling through the two-electron ground state of the system. The presence of the radiative channels makes this phenomena dependent on the number of photons initially in the cavity.

  17. Coherent current states in mesoscopic four-terminal Josephson junction

    International Nuclear Information System (INIS)

    Zareyan, M.; Omelyanchouk, A.N.

    1999-01-01

    A theory is offered for the ballistic 4-terminal Josephson junction. The studied system consist of a mesoscopic two-dimensional normal rectangular layer which is attached on each side to the bulk superconducting banks (terminals). A relation is obtained between the currents through the different terminals, that is valid for arbitrary temperatures and junction sizes. The nonlocal coupling of the supercurrent leads to a new effect, specific for the mesoscopic weak link between two superconducting rings; an applied magnetic flux through one of the rings produces a magnetic flux in the other ring even in the absence of an external flux through the other one. The phase dependent distributions of the local density of Andreev states, of the supercurrents and of the induced order parameter are obtained. The 'interference pattern' for the anomalous average inside the two-dimensional region cam be regulated by the applied magnetic fluxes or the transport currents. For some values of the phase differences between the terminals, the current vortex state and two-dimensional phase slip center appear

  18. Engineering photorespiration: current state and future possibilities.

    Science.gov (United States)

    Peterhansel, C; Krause, K; Braun, H-P; Espie, G S; Fernie, A R; Hanson, D T; Keech, O; Maurino, V G; Mielewczik, M; Sage, R F

    2013-07-01

    Reduction of flux through photorespiration has been viewed as a major way to improve crop carbon fixation and yield since the energy-consuming reactions associated with this pathway were discovered. This view has been supported by the biomasses increases observed in model species that expressed artificial bypass reactions to photorespiration. Here, we present an overview about the major current attempts to reduce photorespiratory losses in crop species and provide suggestions for future research priorities. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

  19. Solar photovoltaics: current state and trends

    Science.gov (United States)

    Milichko, V. A.; Shalin, A. S.; Mukhin, I. S.; Kovrov, A. E.; Krasilin, A. A.; Vinogradov, A. V.; Belov, P. A.; Simovski, C. R.

    2016-08-01

    Basic aspects of current solar photovoltaics (PVs) are reviewed, starting from the recently developed already-on-the-market first-generation solar cells and ending with promising but not yet commercialized third-generation cells and materials possibly leading to new cell designs. The emphasis is on the physical principles of operation of various solar cells, which are divided into several groups according to our classification scheme. To make the picture complete, some technological and economic aspects of the field are discussed. A separate chapter considers antireflection coatings and light-trapping textures — structures which, while not having appeared yet in the PV review literature, are an integral part of the solar cells.

  20. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J.; Rasmussen, Helge H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no known physical barriers that account for such restricted Na+ diffusion, and we examined if changes of activity of the Na+-K+ pump itself cause the transient peak current. Reexposure to K+ reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na+ concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K+-free pipette solution could not be reconciled with restricted subsarcolemmal Na+ diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na+- and K+ concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na+-K+ pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na+-K+ pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K+-induced peak Na+-K+ pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K+-induced peak Na+-K+ pump current reflects the effect of conformation-dependent β1 pump subunit

  1. Dependency in State Transitions of Wind Turbines

    DEFF Research Database (Denmark)

    Herp, Jürgen; Ramezani, Mohammad Hossein; S. Nadimi, Esmaeil

    2017-01-01

    © 2017 IEEE. Turbine states and predicting the transition into failure states ahead of time is important in operation and maintenance of wind turbines. This study presents a method to monitor state transitions of a wind turbine based on the online inference on residuals. In a Bayesian framework...... the impact machine learning concepts have on the predictive performance of the presented models. In conclusion, a study on model residuals is performed to highlight the contribution to wind turbine monitoring. The presented algorithm can consistently detect the state transition under various configurations...

  2. [The current state of obesity in Mexico].

    Science.gov (United States)

    Barrera-Cruz, Antonio; Rodríguez-González, Arturo; Molina-Ayala, Mario Antonio

    2013-01-01

    Excess weight (overweight and obesity) is currently recognized as one of the most important challenges of public health in the world, given its size, speed of growth, and the negative effect on the population who suffers it. Overweight and obesity increases significantly the risk of chronic non-communicable diseases, and premature mortality, as well as the social cost of health. Today, Mexico has the second global prevalence of obesity in the adult population (30 %), which is ten times higher than Korea's or Japan's (4 %). Until 2012, 26 million Mexican adults were overweight, and 22 million, obese. This implies a major challenge for the health sector. Mexico needs to plan and implement strategies and cost-effective actions for the prevention and control of obesity in children, adolescents, and adults. Global experience shows that proper care of obesity and overweight demands to formulate and coordinate efficient multi-sectoral strategies for enhancing protective factors to health, particularly to modify individual behavior, family and community.

  3. ECLAIRs detection plane: current state of development

    Science.gov (United States)

    Lacombe, K.; Pons, R.; Amoros, C.; Atteia, J.-L.; Barret, D.; Billot, M.; Bordon, S.; Cordier, B.; Gevin, O.; Godet, O.; Gonzalez, F.; Houret, B.; Mercier, K.; Mandrou, P.; Marty, W.; Nasser, G.; Rambaud, D.; Ramon, P.; Rouaix, G.; Waegebaert, V.

    2014-07-01

    ECLAIRs, a 2-D coded-mask imaging camera on-board the Sino-French SVOM space mission, will detect and locate Gamma-ray bursts (GRBs) in near real time in the 4-150 keV energy band. The design of ECLAIRs has been mainly driven by the objective of achieving a low-energy threshold of 4 keV, unprecedented for this type of instrument. The detection plane is an assembly of 6400 Schottky CdTe semiconductor detectors of size 4x4x1 mm3 organized on elementary hybrid matrices of 4x8 detectors. The detectors will be polarized from -300V to -500V and operated at -20°C to reduce both the leakage current and the polarization effect induced by the Schottky contact. The remarkable low-energy threshold homogeneity required for the detection plane has been achieved thanks to: i) an extensive characterization and selection of the detectors, ii) the development of a specific low-noise 32-channel ASIC, iii) the realization of an innovative hybrid module composed of a thick film ceramic (holding 32 CdTe detectors with their high voltage grid), associated to an HTCC ceramic (housing the ASIC chip within an hermetic enclosure). In this paper, we start describing a complete hybrid matrix, and then the manufacturing of a first set of 50 matrices (representing 1600 detectors, i.e. a quarter of ECLAIRs detector's array). We show how this manufacturing allowed to validate the different technologies used for this hybridization, as well as the industrialization processes. During this phase, we systematically measured the leakage current on Detector Ceramics after an outgassing, and the Equivalent Noise Charge (ENC) for each of the 32 channels on ASIC Ceramics, in order to optimize the coupling of the two ceramics. Finally, we performed on each hybrid module, spectral measurements at -20°C in our vacuum chamber, using several calibrated radioactive sources (241Am and 55Fe), to check the performance homogeneity of the 50 modules. The results demonstrated that the 32-detector hybrid matrices

  4. Current state of molecular imaging research

    International Nuclear Information System (INIS)

    Grimm, J.; Wunder, A.

    2005-01-01

    The recent years have seen significant advances in both molecular biology, allowing the identification of genes and pathways related to disease, and imaging technologies that allow for improved spatial and temporal resolution, enhanced sensitivity, better depth penetration, improved image processing, and beneficial combinations of different imaging modalities. These advances have led to a paradigm shift in the scope of diagnostic imaging. The traditional role of radiological diagnostic imaging is to define gross anatomy and structure in order to detect pathological abnormalities. Available contrast agents are mostly non-specific and can be used to image physiological processes such as changes in blood volume, flow, and perfusion but not to demonstrate pathological alterations at molecular levels. However, alterations at the anatomical-morphological level are relatively late manifestations of underlying molecular changes. Using molecular probes or markers that bind specifically to molecular targets allows for the non-invasive visualization and quantitation of biological processes such as gene expression, apoptosis, or angiogenesis at the molecular level within intact living organisms. This rapidly evolving, multidisciplinary approach, referred to as molecular imaging, promises to enable early diagnosis, can provide improved classification of stage and severity of disease, an objective assessment of treatment efficacy, and a reliable prognosis. Furthermore, molecular imaging is an important tool for the evaluation of physiological and pathophysiological processes, and for the development of new therapies. This article comprises a review of current technologies of molecular imaging, describes the development of contrast agents and various imaging modalities, new applications in specific disease models, and potential future developments. (orig.)

  5. The US Opioid Crisis: Current Federal and State Legal Issues.

    Science.gov (United States)

    Soelberg, Cobin D; Brown, Raeford E; Du Vivier, Derick; Meyer, John E; Ramachandran, Banu K

    2017-11-01

    The United States is in the midst of a devastating opioid misuse epidemic leading to over 33,000 deaths per year from both prescription and illegal opioids. Roughly half of these deaths are attributable to prescription opioids. Federal and state governments have only recently begun to grasp the magnitude of this public health crisis. In 2016, the Centers for Disease Control and Prevention released their Guidelines for Prescribing Opioids for Chronic Pain. While not comprehensive in scope, these guidelines attempt to control and regulate opioid prescribing. Other federal agencies involved with the federal regulatory effort include the Food and Drug Administration (FDA), the Drug Enforcement Agency (DEA), and the Department of Justice. Each federal agency has a unique role in helping to stem the burgeoning opioid misuse epidemic. The DEA, working with the Department of Justice, has enforcement power to prosecute pill mills and physicians for illegal prescribing. The DEA could also implement use of prescription drug monitoring programs (PDMPs), currently administered at the state level, and use of electronic prescribing for schedule II and III medications. The FDA has authority to approve new and safer formulations of immediate- and long-acting opioid medications. More importantly, the FDA can also ask pharmaceutical companies to cease manufacturing a drug. Additionally, state agencies play a critical role in reducing overdose deaths, protecting the public safety, and promoting the medically appropriate treatment of pain. One of the states' primary roles is the regulation of practice of medicine and the insurance industry within their borders. Utilizing this authority, states can both educate physicians about the dangers of opioids and make physician licensure dependent on registering and using PDMPs when prescribing controlled substances. Almost every state has implemented a PDMP to some degree; however, in addition to mandating their use, increased interstate

  6. An economical state-dependent telecloning for a multiparticle GHZ state

    Science.gov (United States)

    Meng, Fan-Xu; Yu, Xu-Tao; Zhang, Zai-Chen

    2018-03-01

    The scheme for a 1-3 economical state-dependent telecloning of a multiparticle GHZ state is proposed. It shows that every one of spatially separated three receivers obtains one copy which is dependent on original state. Fidelity can hit to the optimal fidelity 5/6. Meantime, we also propose a 1-3 asymmetric economical telecloning of a particular multiparticle GHZ state by parameterizing coefficients of state in the channel. The three fidelities can reach the best match that is the same as the symmetric case. Furthermore, the above two schemes can be generalized into the case of 1-M(M=2k+1,k>0) telecloning of a multiparticle GHZ state. Satisfying some certain conditions, optimal fidelities with 1/2+(M+1)/4M can be obtained. As without ancilla in the channel, the number of entangled particles is less than one in current schemes and fidelities can be optimal if the original state is an equatorial state.

  7. Simultaneous specimen current and time-dependent cathodoluminescence measurements on gallium nitride

    Energy Technology Data Exchange (ETDEWEB)

    Campo, E. M., E-mail: e.campo@bangor.ac.uk; Hopkins, L. [School of Electronic Engineering, Bangor University, Gwynedd LL57 1UT (United Kingdom); Pophristic, M. [Department of Chemistry and Biochemistry, University of the Science, Philadelphia, Pennsylvania 19104 (United States); Ferguson, I. T. [Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409 (United States)

    2016-06-28

    Time-dependent cathodoluminescence (CL) and specimen current (SC) are monitored to evaluate trapping behavior and evolution of charge storage. Examination of CL and SC suggests that the near band edge emission in GaN is reduced primarily by the activation of traps upon irradiation, and Gallium vacancies are prime candidates. At the steady state, measurement of the stored charge by empiric-analytical methods suggests that all available traps within the interaction volume have been filled, and that additional charge is being stored interstitially, necessarily beyond the interaction volume. Once established, the space charge region is responsible for the steady state CL emission and, prior to build up, it is responsible for the generation of diffusion currents. Since the non-recombination effects resulting from diffusion currents that develop early on are analogous to those leading to device failure upon aging, this study is fundamental toward a holistic insight into optical properties in GaN.

  8. Current State of Public Cemeteries in River State, nigeria | Douglas ...

    African Journals Online (AJOL)

    Cemeteries or 'sleeping places' are where bodies or cremated remains are buried. Dead bodies are essentially 'wastes' and their improper disposal in the form of burial may come with health implications. This is particularly apt in Nigeria and indeed Rivers State where unsupervised burials are carried out in homes ...

  9. State dependent optimization of measurement policy

    International Nuclear Information System (INIS)

    Konkarikoski, K

    2010-01-01

    Measurements are the key to rational decision making. Measurement information generates value, when it is applied in the decision making. An investment cost and maintenance costs are associated with each component of the measurement system. Clearly, there is - under a given set of scenarios - a measurement setup that is optimal in expected (discounted) utility. This paper deals how the measurement policy optimization is affected by different system states and how this problem can be tackled.

  10. Maximum time-dependent space-charge limited diode currents

    Energy Technology Data Exchange (ETDEWEB)

    Griswold, M. E. [Tri Alpha Energy, Inc., Rancho Santa Margarita, California 92688 (United States); Fisch, N. J. [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States)

    2016-01-15

    Recent papers claim that a one dimensional (1D) diode with a time-varying voltage drop can transmit current densities that exceed the Child-Langmuir (CL) limit on average, apparently contradicting a previous conjecture that there is a hard limit on the average current density across any 1D diode, as t → ∞, that is equal to the CL limit. However, these claims rest on a different definition of the CL limit, namely, a comparison between the time-averaged diode current and the adiabatic average of the expression for the stationary CL limit. If the current were considered as a function of the maximum applied voltage, rather than the average applied voltage, then the original conjecture would not have been refuted.

  11. Frequency dependence of alternating current electrospray ionization mass spectrometry.

    Science.gov (United States)

    Chetwani, Nishant; Cassou, Catherine A; Go, David B; Chang, Hsueh-Chia

    2011-04-15

    The novel effects resulting from the entrainment of low mobility ions during alternating current (ac) electrospray ionization are examined through mass spectrometry and voltage/current measurements. Curious phenomena such as pH modulation at high frequencies (>150 kHz) of an applied ac electric field are revealed and explained using simple mechanistic arguments. Current measurements are utilized to supplement these observations, and a simplified one-dimensional transient diffusion model for charge transport is used to arrive at a scaling law that provides better insight into the ac electrospray ionization process. Moreover, because of the different pathway for ion formation in comparison to direct current (dc) electrospray, ac electrospray (at frequencies >250 kHz) is shown to reduce the effects of ionization suppression in a mixture of two molecules with different surface activities. © 2011 American Chemical Society

  12. Measurement of Nuclear Dependence in Inclusive Charged Current Neutrino Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Tice, Brian George [Rutgers Univ., New Brunswick, NJ (United States)

    2014-01-01

    Neutrino experiments use heavy nuclei (C, Fe, Pb) to achieve necessary statistics. However, the use of heavy nuclei exposes these experiments to the nuclear dependence of neutrino-nucleus cross sections, which are poorly known and difficult to model. This dissertation presents an analysis of the nuclear dependence of inclusive chargedcurrent neutrino scattering using events in carbon, iron, lead, and scintillator targets of the MINERvA detector. MINERvA (Main INjector ExpeRiment for -A) is a few-GeV neutrinonucleus scattering experiment at Fermilab.

  13. State-dependent impulses boundary value problems on compact interval

    CERN Document Server

    Rachůnková, Irena

    2015-01-01

    This book offers the reader a new approach to the solvability of boundary value problems with state-dependent impulses and provides recently obtained existence results for state dependent impulsive problems with general linear boundary conditions. It covers fixed-time impulsive boundary value problems both regular and singular and deals with higher order differential equations or with systems that are subject to general linear boundary conditions. We treat state-dependent impulsive boundary value problems, including a new approach giving effective conditions for the solvability of the Dirichlet problem with one state-dependent impulse condition and we show that the depicted approach can be extended to problems with a finite number of state-dependent impulses. We investigate the Sturm–Liouville boundary value problem for a more general right-hand side of a differential equation. Finally, we offer generalizations to higher order differential equations or differential systems subject to general linear boundary...

  14. Historical Trust Levels Predict Current Welfare State Design

    DEFF Research Database (Denmark)

    Bergh, Andreas; Bjørnskov, Christian

    Using cross-sectional data for 76 countries, we apply instrumental variable techniques based on pronoun drop, temperature and monarchies to demonstrate that historical trust levels predict several indicators of current welfare state design, including universalism and high levels of regulatory...... freedom. We argue that high levels of trust and trustworthiness are necessary, but not sufficient, conditions for societies to develop successful universal welfare states that would otherwise be highly vulnerable to free riding and fraudulent behavior. Our results do not exclude positive feedback from...... welfare state universalism to individual trust, although we claim that the important causal link runs from historically trust levels to current welfare state design....

  15. The Current State of the United States Army: The Numbers, the Needs, and the Consequences

    Science.gov (United States)

    2009-02-20

    The Current State of the United States Army: The Numbers, the Needs , and the Consequences...DATES COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE The Current State of the United States Army: The Numbers, the Needs , and the

  16. Current state about the cuaternary knowledge of Uruguay

    International Nuclear Information System (INIS)

    Anton, D; Goso, H.

    1974-01-01

    This work is about current state of cuaternary knowledge Uruguayan. It is considered that the cuaternary presented a change from the hot and dry weather of the Pliocene to more humid and colder weather in Uruguay.

  17. Direct Measurement of Nuclear Dependence of Charged Current Quasielasticlike Neutrino Interactions Using MINERvA

    Energy Technology Data Exchange (ETDEWEB)

    Betancourt, M.; Ghosh, A.; Walton, T.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Bodek, A.; Bravar, A.; Cai, T.; Martinez Caicedo, D. A.; Carneiro, M. F.; Dytman, S. A.; Díaz, G. A.; Felix, J.; Fields, L.; Fine, R.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kiveni, M.; Kleykamp, J.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman,; Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Sobczyk, J. T.; Solano Salinas, C. J.; Sánchez Falero, S.; Valencia, E.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.

    2017-08-01

    Charged-current νμ interactions on carbon, iron, and lead with a final state hadronic system of one or more protons with zero mesons are used to investigate the influence of the nuclear environment on quasielasticlike interactions. The transferred four-momentum squared to the target nucleus, Q2, is reconstructed based on the kinematics of the leading proton, and differential cross sections versus Q2 and the cross-section ratios of iron, lead, and carbon to scintillator are measured for the first time in a single experiment. The measurements show a dependence on the atomic number. While the quasielasticlike scattering on carbon is compatible with predictions, the trends exhibited by scattering on iron and lead favor a prediction with intranuclear rescattering of hadrons accounted for by a conventional particle cascade treatment. These measurements help discriminate between different models of both initial state nucleons and final state interactions used in the neutrino oscillation experiments.

  18. Dependence of the current renormalisation constants on the quark mass

    International Nuclear Information System (INIS)

    Crisafulli, M.; Vladikas, A.

    1995-01-01

    We study the behaviour of the vector and axial current renormalisation constants Z V and Z A as a function of the quark mass, m q . We show that sizeable O(am q ) and O(g 2 0 am q ) systematic effects are present in the Wilson and Clover cases respectively. We find that the prescription of Kronfeld, Lepage and Mackenzie for correcting these artefacts is not always successful. ((orig.))

  19. Neurobiological Correlates of State-Dependent Context Fear

    Science.gov (United States)

    Meyer, Mariah A. A.; Corcoran, Kevin A.; Chen, Helen J.; Gallego, Sonia; Li, Guanguan; Tiruveedhula, Veda V.; Cook, James M.; Radulovic, Jelena

    2017-01-01

    Retrieval of fear memories can be state-dependent, meaning that they are best retrieved if the brain states at encoding and retrieval are similar. Such states can be induced by activating extrasynaptic ?-aminobutyric acid type A receptors (GABAAR) with the broad a-subunit activator gaboxadol. However, the circuit mechanisms and specific subunits…

  20. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

    2016-03-08

    The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect

  1. Current status on narrow N anti N states

    International Nuclear Information System (INIS)

    Chung, S.U.

    1979-09-01

    An attempt is made to summarize the experimental status of narrow B anti B states as of mid-1979. In particular, concentration is placed on the current experimental situations and prospects regarding three serious contenders for the so-called baryonium states. Theoretical concepts of baryoniums, narrow N anti N states known as S(1935), anti pp(2020), and anti pp(2204), and some forthcoming results, and problems of the above three resonances are discussed. 31 references

  2. Effect of operating current dependent series resistance on the fill factor of a solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Dadu, Meena; Kapoor, A.; Tripathi, K.N. [Department of Electronic Science, University of Delhi, South Campus, Benito Juarez road, -110 021 New Delhi (India)

    2002-02-01

    The fill factor of a solar cell depends upon the series resistance, reverse saturation current, diode quality factor, operating current and voltage. Since the series resistance itself depends upon the operating current (or voltage), it makes the evaluation of fill factor very complicated. In this paper, we have evaluated the fill factor of a solar cell, taking into account operating current dependence of the series resistance.

  3. Transient and steady-state currents in epoxy resin

    International Nuclear Information System (INIS)

    Guillermin, Christophe; Rain, Pascal; Rowe, Stephen W

    2006-01-01

    Charging and discharging currents have been measured in a diglycidyl ether of bisphenol-A epoxy resin with and without silica fillers, below and above its glass transition temperature T g = 65 deg. C. Both transient and steady-state current densities have been analysed. The average applied fields ranged from 3 to 35 kV mm -1 with a sample thickness of 0.5 mm. Above T g , transient currents suggested a phenomenon of charge injection forming trapped space charges even at low fields. Steady-state currents confirmed that the behaviour was not Ohmic and suggested Schottky-type injection. Below T g , the current is not controlled by the metal-dielectric interface but by the conduction in the volume: the current is Ohmic at low fields and both transient and steady-state currents suggest a phenomenon of space-charge limited currents at high fields. The field threshold is similar in the filler-free and the filled resin. Values in the range 12-17 kV mm -1 have been measured

  4. Tri-State Current Source Inverter With Improved Dynamic Performance

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Loh, Poh Chiang; Wong, Chow Pang

    2008-01-01

    Traditional dc-ac current source inverter (CSI) has a right-half-plane (RHP) zero in its control-to-output transfer function. This RHP zero causes the inverter output to fall before rising when a step increase in command reference is required (commonly known as non-minimum-phase effect). To achieve...... sequence, the inductive boosting and discharging intervals can be decoupled, allowing the RHP zero to be eliminated with only minor circuit modifications (high level control schemes like predictive and multiloop voltage/current control remain unchanged). The designed inverter can be controlled using...... a better dynamic response, this paper proposes the design of a tri-state CSI using only an additional semiconductor switch for introducing unique freewheeling states to the traditional six active and three null states of a CSI. With the freewheeling states inserted appropriately within the inverter state...

  5. 5-HT modulation of hyperpolarization-activated inward current and calcium- dependent outward current in a crustacean motor neuron

    DEFF Research Database (Denmark)

    Kiehn, O.; Harris-Warrick, R. M.

    1992-01-01

    1. Serotonergic modulation of a hyperpolarization-activated inward current, I(h), and a calcium-dependent outward current, I(o(Ca)), was examined in the dorsal gastric (DG) motor neuron, with the use of intracellular recording techniques in an isolated preparation of the crab stomatogastric...... ganglion (STG). 2. Hyperpolarization of the membrane from rest with maintained current pulses resulted in a slow time-dependent relaxation back toward rest and a depolarizing overshoot after termination of the current pulse. In voltage clamp, hyperpolarizing commands negative to approximately -70 mV caused...... a slowly developing inward current, I(h), which showed no inactivation. Repolarization back to the holding potential of -50 mV revealed a slow inward tail current. 3. The reversal potential for I(h) was approximately -35 mV. Raising extracellular K+ concentration ([K+](o)) from 11 to 22 mM enhanced...

  6. Subjective Probabilities for State-Dependent Continuous Utility

    NARCIS (Netherlands)

    P.P. Wakker (Peter)

    1987-01-01

    textabstractFor the expected utility model with state dependent utilities, Karni, Schmeidler and Vind (1983) have shown how to recover uniquely the involved subjective probabilities if the preferences, contingent on a hypothetical probability distribution over the state space, are known. This they

  7. Coherent states of general time-dependent harmonic oscillator

    Indian Academy of Sciences (India)

    Abstract. By introducing an invariant operator, we obtain exact wave functions for a general time-dependent quadratic harmonic oscillator. The coherent states, both in x- and p-spaces, are calculated. We confirm that the uncertainty product in coherent state is always larger than Η/2 and is equal to the minimum of the ...

  8. Observer for heat equation with state-dependent switched parameters

    DEFF Research Database (Denmark)

    Bendtsen, Jan Dimon; Leth, John-Josef

    2016-01-01

    This paper considers estimation of an unknown state function in the heat equation with state-dependent parameter values. The work is motivated by phase transitions in physical media, e.g., thawing of water or foodstuff, welding and casting processes. We point out that known solution to standard...

  9. Remarks on time-dependent [current]-density functional theory for open quantum systems.

    Science.gov (United States)

    Yuen-Zhou, Joel; Aspuru-Guzik, Alán

    2013-08-14

    Time-dependent [current]-density functional theory for open quantum systems (OQS) has emerged as a formalism that can incorporate dissipative effects in the dynamics of many-body quantum systems. Here, we review and clarify some formal aspects of these theories that have been recently questioned in the literature. In particular, we provide theoretical support for the following conclusions: (1) contrary to what we and others had stated before, within the master equation framework, there is in fact a one-to-one mapping between vector potentials and current densities for fixed initial state, particle-particle interaction, and memory kernel; (2) regardless of the first conclusion, all of our recently suggested Kohn-Sham (KS) schemes to reproduce the current and particle densities of the original OQS, and in particular, the use of a KS closed driven system, remains formally valid; (3) the Lindblad master equation maintains the positivity of the density matrix regardless of the time-dependence of the Hamiltonian or the dissipation operators; (4) within the stochastic Schrödinger equation picture, a one-to-one mapping from stochastic vector potential to stochastic current density for individual trajectories has not been proven so far, except in the case where the vector potential is the same for every member of the ensemble, in which case, it reduces to the Lindblad master equation picture; (5) master equations may violate certain desired properties of the density matrix, such as positivity, but they remain as one of the most useful constructs to study OQS when the environment is not easily incorporated explicitly in the calculation. The conclusions support our previous work as formally rigorous, offer new insights into it, and provide a common ground to discuss related theories.

  10. Stress dependence of the critical currents in neutron irradiated (RE)BCO coated conductors

    Science.gov (United States)

    Emhofer, J.; Eisterer, M.; Weber, H. W.

    2013-03-01

    The application of HTS coated conductors in future fusion or accelerator magnets is currently of increasing interest. High Lorentz forces and therefore high hoop stresses act on the conductors in large coils. The conductor is furthermore exposed to neutron radiation in fusion or accelerator magnets. The expected neutron fluence over the desired lifetime of such magnets can be simulated by irradiation experiments in a fission reactor. The coated conductors were characterized in the pristine state and after irradiation to a fast neutron fluence of 1 × 1022 m-2 (ITER design fluence). The sensitivity of the critical currents to applied stress was measured in liquid nitrogen. The cold part of the setup was positioned within a rotatable split coil electro-magnet to assess the Ic-anisotropy up to 1.4 T under maximum Lorentz force configuration. The Ic-sensitivity to applied stress changed significantly in the GdBCO/IBAD conductor after irradiation, whereas nearly no change was observed in the YBCO/RABiTS conductor. Furthermore, Ic and Tc were strongly reduced in the GdBCO/IBAD sample after irradiation. The angular dependence of Ic changed for both samples in different ways after the irradiation, but no change in the angular dependence was observed upon applying stress. The high neutron capture cross-section of Gd and the resulting strong reduction of Tc seem to be responsible for the different stress dependences of Ic in irradiated Gd-123 coated conductors.

  11. Probabilistic quantum cloning of a subset of linearly dependent states

    Science.gov (United States)

    Rui, Pinshu; Zhang, Wen; Liao, Yanlin; Zhang, Ziyun

    2018-02-01

    It is well known that a quantum state, secretly chosen from a certain set, can be probabilistically cloned with positive cloning efficiencies if and only if all the states in the set are linearly independent. In this paper, we focus on probabilistic quantum cloning of a subset of linearly dependent states. We show that a linearly-independent subset of linearly-dependent quantum states {| Ψ 1⟩,| Ψ 2⟩,…,| Ψ n ⟩} can be probabilistically cloned if and only if any state in the subset cannot be expressed as a linear superposition of the other states in the set {| Ψ 1⟩,| Ψ 2⟩,…,| Ψ n ⟩}. The optimal cloning efficiencies are also investigated.

  12. Pancreatic Cancer Diagnostics and Treatment – Current State

    Directory of Open Access Journals (Sweden)

    Zdeněk Krška

    2015-01-01

    Full Text Available Pancreatic ductal adenocarcinoma (PDAC represents permanent and ever rising issue worldwide. Five-year survival does not exceed 3 to 6%, i.e. the worst result among solid tumours. The article evaluates the current state of PDAC diagnostics and treatment specifying also development and trends. Percentage of non-resectable tumours due to locally advanced or metastatic condition varies 60–80%, mostly over 80%. Survival with non-resectable PDAC is 4 to 8 months (median 3.5. In contrast R0 resection shows the survival 18–27 months. Laboratory and imaging screening methods are not indicated on large scale. Risk factors are smoking, alcohol abuse, chronic pancreatitis, diabetes mellitus. Genetic background in most PDAC has not been detected yet. Some genes connected with high risk of PDAC (e.g. BRCA2, PALB2 have been identified as significant and highly penetrative, but link between PDAC and these genes can be seen only in 10–20%. This article surveys perspective oncogenes, tumour suppressor genes, microRNA. Albeit CT is still favoured over other imaging methods, involvement of NMR rises. Surgery prefers the “vessel first” approach, which proves to be justified especially in R0 resection. According to EBM immunotherapy same as radiotherapy are not significant in PDAC treatment. Chemotherapy shows limited importance in conversion treatment of locally advanced or borderline tumours or in case of metastatic spread. Unified procedures cannot be defined due to inhomogenous arrays. Surgical resection is the only chance for curative treatment of PDAC and depends mainly on timely indication for surgery and quality of multidisciplinary team in a high-volume centre.

  13. A Perspective on the Current State of Death Education

    Science.gov (United States)

    Wass, Hannelore

    2004-01-01

    The author offers some views on the current state of death education with focus on the sparing attention given the death education of health professionals and of grief counselors. There is need for improved integration of the knowledge accumulated in the study of death, dying, and bereavement into the basic curricula of the parent disciplines and…

  14. Ground State Energy of Current Carriers in Graphene

    OpenAIRE

    Ratnikov, P. V.; Silin, A. P.

    2008-01-01

    The ground state energy of current carriers in graphene considered as a zero-gap semiconductor was calculated in the two-band approximation. The condition of the electronic (hole) system stability in graphene was obtained. The possibility of the zero-gap semiconductor-semimetal transition was discussed.

  15. [Physiotherapeutic care marketing research: current state-of-the art].

    Science.gov (United States)

    Babaskin, D V

    2011-01-01

    Successful introduction of modern technologies into the national health care systems strongly depends on the current pharmaceutical market situation. The present article is focused on the peculiarities of marketing research with special reference to physiotherapeutic services and commodities. Analysis of the structure and sequence of marketing research processes is described along with the methods applied for the purpose including their support by the use of Internet resources and technologies.

  16. Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current

    Directory of Open Access Journals (Sweden)

    Shunbing Zhao

    2010-05-01

    Full Text Available Linear leak currents have been implicated in the regulation of neuronal excitability, generation of neuronal and network oscillations, and network state transitions. Yet, few studies have directly tested the dependence of network oscillations on leak currents or explored the role of leak currents on network activity. In the oscillatory pyloric network of decapod crustaceans neuromodulatory inputs are necessary for pacemaker activity. A large subset of neuromodulators is known to activate a single voltage-gated inward current IMI, which has been shown to regulate the rhythmic activity of the network and its pacemaker neurons. Using the dynamic clamp technique, we show that the crucial component of IMI for the generation of oscillatory activity is only a close-to-linear portion of the current-voltage relationship. The nature of this conductance is such that the presence or the absence of neuromodulators effectively regulates the amount of leak current and the input resistance in the pacemaker neurons. When deprived of neuromodulatory inputs, pyloric oscillations are disrupted; yet, a linear reduction of the total conductance in a single neuron within the pacemaker group recovers not only the pacemaker activity in that neuron, but also leads to a recovery of oscillations in the entire pyloric network. The recovered activity produces proper frequency and phasing that is similar to that induced by neuromodulators. These results show that the passive properties of pacemaker neurons can significantly affect their capacity to generate and regulate the oscillatory activity of an entire network, and that this feature is exploited by neuromodulatory inputs.

  17. Investigation of unstable periodic space-time states in distributed active system with supercritical current

    International Nuclear Information System (INIS)

    Koronovskij, A.A.; Rempen, I.S.; Khramov, A.E.

    2003-01-01

    The set of the unstable periodic space-time states, characterizing the chaotic space-time dynamics of the electron beam with the supercritical current in the Pierce diode is discussed. The Lyapunov indicators of the revealed instable space-time states of the chaotic dynamics of the distributed self-excited system are calculated. It is shown that change in the set of the unstable periodic states in dependence on the Pierce parameter is determined by change in the various orbits stability, which is demonstrated by the values of senior Lyapunov unstable state index [ru

  18. Steady-state current drive by lower hybrid waves

    International Nuclear Information System (INIS)

    Belyanskaya, N.V.; Dnestrovskii, Y.N.; Kostomarov, D.P.; Smirnov, A.P.

    1986-01-01

    Steady-state current drive in a plasma by lower-hybrid waves with a square-wave spectrum is analyzed in the linear approximation. A linearized two-dimensional kinetic equation in velocity space for the electron distribution function is reduced to a one-dimensional expansion in Legendre polynomials. A numerical solution is found for the complete equation, and an analytic solution is found for the asymptotic equation. The results can be used to determine the effect of the spectral width of the excited waves on the efficiency of the current drive. The analytic solution agrees well with the numerical solution

  19. Time dependent critical state in disks and rings

    NARCIS (Netherlands)

    Hemmes, Herman K.; Kuper, A.R.; Kuper, A.R.; van de Klundert, L.J.M.; van de Klundert, L.J.M.

    1991-01-01

    The authors have developed a model to calculate the response of the current distribution in disks and rings to a time-dependent applied magnetic field. In the model, the ring (or disk) is divided into concentric segments. The segments are assumed to be inductively coupled to each other and to the

  20. Elections, Private Information, and State-Dependent Candidate Quality

    DEFF Research Database (Denmark)

    Jensen, Thomas

    is that candidate quality is state-dependent. Our main insight is that if the electorate is sufficiently well informed then there exists an equilibrium where the candidates' policy positions reveal their information and the policy outcome is the same as it would be if voters were fully informed (the median policy...

  1. Selective maintenance of multi-state systems with structural dependence

    NARCIS (Netherlands)

    Dao Duc Cuong, Cuong; Zuo, Ming J.

    2017-01-01

    This paper studies the selective maintenance problem for multi-state systems with structural dependence. Each component can be in one of multiple working levels and several maintenance actions are possible to a component in a maintenance break. The components structurally form multiple hierarchical

  2. Integrated vehicle dynamics control using State Dependent Riccati Equations

    NARCIS (Netherlands)

    Bonsen, B.; Mansvelders, R.; Vermeer, E.

    2010-01-01

    In this paper we discuss a State Dependent Riccati Equations (SDRE) solution for Integrated Vehicle Dynamics Control (IVDC). The SDRE approach is a nonlinear variant of the well known Linear Quadratic Regulator (LQR) and implements a quadratic cost function optimization. A modified version of this

  3. Filled and empty states of carbon nanotubes in water: Dependence ...

    Indian Academy of Sciences (India)

    Filled and empty states of carbon nanotubes in water: Dependence on nanotube diameter, wall thickness and dispersion interactions. Malay Rana ... The thickness of the nanotube wall, however, is found to have only minor effects on the density profiles, hydrogen bond network and the wetting characteristics. This indicates ...

  4. [The current state and development prospectives of military nephrology].

    Science.gov (United States)

    Nagibovich, O A; Golota, A S; Krassiĭ, A B

    2014-05-01

    This article is dedicated to the current state and prospectives of military nephrology. Using as examples the nephrology services of the armed forces of Serbia, France, Great Britain and USA it is shown that this branch of military healthcare plays an important role abroad. The brief review of military nephrology formation and development history demonstrates the growing significance of military nephrology in the general system of medical care at the battlefield.

  5. State-dependent neutral delay equations from population dynamics.

    Science.gov (United States)

    Barbarossa, M V; Hadeler, K P; Kuttler, C

    2014-10-01

    A novel class of state-dependent delay equations is derived from the balance laws of age-structured population dynamics, assuming that birth rates and death rates, as functions of age, are piece-wise constant and that the length of the juvenile phase depends on the total adult population size. The resulting class of equations includes also neutral delay equations. All these equations are very different from the standard delay equations with state-dependent delay since the balance laws require non-linear correction factors. These equations can be written as systems for two variables consisting of an ordinary differential equation (ODE) and a generalized shift, a form suitable for numerical calculations. It is shown that the neutral equation (and the corresponding ODE--shift system) is a limiting case of a system of two standard delay equations.

  6. Evaluation of the Current State of Integrated Water Quality Modelling

    Science.gov (United States)

    Arhonditsis, G. B.; Wellen, C. C.; Ecological Modelling Laboratory

    2010-12-01

    Environmental policy and management implementation require robust methods for assessing the contribution of various point and non-point pollution sources to water quality problems as well as methods for estimating the expected and achieved compliance with the water quality goals. Water quality models have been widely used for creating the scientific basis for management decisions by providing a predictive link between restoration actions and ecosystem response. Modelling water quality and nutrient transport is challenging due a number of constraints associated with the input data and existing knowledge gaps related to the mathematical description of landscape and in-stream biogeochemical processes. While enormous effort has been invested to make watershed models process-based and spatially-distributed, there has not been a comprehensive meta-analysis of model credibility in watershed modelling literature. In this study, we evaluate the current state of integrated water quality modeling across the range of temporal and spatial scales typically utilized. We address several common modeling questions by providing a quantitative assessment of model performance and by assessing how model performance depends on model development. The data compiled represent a heterogeneous group of modeling studies, especially with respect to complexity, spatial and temporal scales and model development objectives. Beginning from 1992, the year when Beven and Binley published their seminal paper on uncertainty analysis in hydrological modelling, and ending in 2009, we selected over 150 papers fitting a number of criteria. These criteria involved publications that: (i) employed distributed or semi-distributed modelling approaches; (ii) provided predictions on flow and nutrient concentration state variables; and (iii) reported fit to measured data. Model performance was quantified with the Nash-Sutcliffe Efficiency, the relative error, and the coefficient of determination. Further, our

  7. State-dependent intrinsic predictability of cortical network dynamics.

    Directory of Open Access Journals (Sweden)

    Leila Fakhraei

    Full Text Available The information encoded in cortical circuit dynamics is fleeting, changing from moment to moment as new input arrives and ongoing intracortical interactions progress. A combination of deterministic and stochastic biophysical mechanisms governs how cortical dynamics at one moment evolve from cortical dynamics in recently preceding moments. Such temporal continuity of cortical dynamics is fundamental to many aspects of cortex function but is not well understood. Here we study temporal continuity by attempting to predict cortical population dynamics (multisite local field potential based on its own recent history in somatosensory cortex of anesthetized rats and in a computational network-level model. We found that the intrinsic predictability of cortical dynamics was dependent on multiple factors including cortical state, synaptic inhibition, and how far into the future the prediction extends. By pharmacologically tuning synaptic inhibition, we obtained a continuum of cortical states with asynchronous population activity at one extreme and stronger, spatially extended synchrony at the other extreme. Intermediate between these extremes we observed evidence for a special regime of population dynamics called criticality. Predictability of the near future (10-100 ms increased as the cortical state was tuned from asynchronous to synchronous. Predictability of the more distant future (>1 s was generally poor, but, surprisingly, was higher for asynchronous states compared to synchronous states. These experimental results were confirmed in a computational network model of spiking excitatory and inhibitory neurons. Our findings demonstrate that determinism and predictability of network dynamics depend on cortical state and the time-scale of the dynamics.

  8. State-Dependent Implication and Equivalence in Quantum Logic

    Directory of Open Access Journals (Sweden)

    Fedor Herbut

    2012-01-01

    Full Text Available Ideal occurrence of an event (projector leads to the known change of a state (density operator into (the Lüders state. It is shown that two events and give the same Lüders state if and only if the equivalence relation is valid. This relation determines equivalence classes. The set of them and each class, are studied in detail. It is proved that the range projector of the Lüders state can be evaluated as , where denotes the greatest lower bound, and is the null projector of . State-dependent implication extends absolute implication (which, in turn, determines the entire structure of quantum logic. and are investigated in a closely related way to mutual benefit. Inherent in the preorder is the state-dependent equivalence , defining equivalence classes in a given Boolean subalgebra. The quotient set, in which the classes are the elements, has itself a partially ordered structure, and so has each class. In a complete Boolean subalgebra, both structures are complete lattices. Physical meanings are discussed.

  9. Time-Dependent-Asymmetric-Linear-Parsimonious Ancestral State Reconstruction.

    Science.gov (United States)

    Didier, Gilles

    2017-10-01

    The time-dependent-asymmetric-linear parsimony is an ancestral state reconstruction method which extends the standard linear parsimony (a.k.a. Wagner parsimony) approach by taking into account both branch lengths and asymmetric evolutionary costs for reconstructing quantitative characters (asymmetric costs amount to assuming an evolutionary trend toward the direction with the lowest cost). A formal study of the influence of the asymmetry parameter shows that the time-dependent-asymmetric-linear parsimony infers states which are all taken among the known states, except for some degenerate cases corresponding to special values of the asymmetry parameter. This remarkable property holds in particular for the Wagner parsimony. This study leads to a polynomial algorithm which determines, and provides a compact representation of, the parametric reconstruction of a phylogenetic tree, that is for all the unknown nodes, the set of all the possible reconstructed states associated with the asymmetry parameters leading to them. The time-dependent-asymmetric-linear parsimony is finally illustrated with the parametric reconstruction of the body size of cetaceans.

  10. The Current State of Pediatric Sports Medicine: A Workforce Analysis.

    Science.gov (United States)

    Engelman, Glenn; Koutures, Chris; Provance, Aaron

    2016-01-01

    Pediatric sports medicine is an evolving pediatric subspecialty. No workforce data currently exists describing the current state of pediatric sports medicine. The goal of this survey is to contribute information to the practicing pediatric sports medicine specialist, employers and other stakeholders regarding the current state of pediatric sports medicine. The Workforce Survey was conducted by the American Academy of Pediatrics (AAP) Division of Workforce and Medical Education Policy (WMEP) and included a 44-item standard questionnaire online addressing training, clinical practice and demographic characteristics as well as the 24-item AAP Council on Sports Medicine and Fitness (COSMF) questionnaire. Descriptive statistics were used to summarize all survey responses. Bivariate relationships were tested for statistical significance using Chi square. 145 surveys were returned, which represented a 52.7% response rate for eligible COSMF members and board certified non-council responders. The most common site of employment among respondents was university-based clinics. The respondents board certified in sports medicine were significantly more likely to perform fracture management, casting and splinting, neuropsychological testing and injections compared to those not board certified in sports medicine. A large proportion of respondents held an academic/medical school appointment. Increases were noted in both patient volume and the complexity of the injuries the specialists were treating. This pediatric sports medicine workforce study provides previously unappreciated insight into practice arrangements, weekly duties, procedures, number of patients seen, referral patterns, and potential future trends of the pediatric sports medicine specialist.

  11. [Current state and prospects of military personnel health monitoring].

    Science.gov (United States)

    Rezvantsev, M V; Kuznetsov, S M; Ivanov, V V; Zakurdaev, V V

    2014-01-01

    The current article is dedicated to some features of the Russian Federation Armed Forces military personnel health monitoring such as legal and informational provision, methodological basis of functioning, historical aspect of formation and development of the social and hygienic monitoring in the Russian Federation Armed Forces. The term "military personnel health monitoring" is defined as an analytical system of constant and long-term observation, analysis, assessment, studying of factors determined the military personnel health, these factors correlations, health risk factors management in order to minimize them. The current state of the military personnel health monitoring allows coming to the conclusion that the military health system does have forces and resources for state policy of establishing the population health monitoring system implementation. The following directions of the militarily personnel health monitoring improvement are proposed: the Russian Federation Armed Forces medical service record and report system reorganization bringing it closer to the civilian one, implementation of the integrated approach to the medical service informatisation, namely, military personnel health status and medical service resources monitoring. The leading means in this direction are development and introduction of a military serviceman individual health status monitoring system on the basis of a serviceman electronic medical record card. Also it is proposed the current Russian Federation Armed Forces social and hygienic monitoring improvement at the expense of informational interaction between the two subsystems on the basis of unified military medical service space.

  12. Single-electron states near a current-carrying core

    International Nuclear Information System (INIS)

    Masale, M.

    2004-01-01

    The energy spectrum of an electron confined near a current-carrying core is obtained as a function of the azimuthal applied magnetic field within the effective-mass approximation. The double degeneracy of the non-zero electron's axial wave number (k z ) states is lifted by the current-induced magnetic field while that of the non-zero azimuthal quantum number (m) states is preserved. A further analysis is the evaluations of the oscillator strengths for optical transitions involving the lowest-order pair of the electron's energy subbands within the dipole approximation. The radiation field is taken as that of elliptically polarized light incident along the core axis. In this polarization and within the dipole approximation, the allowed transitions are only those governed by the following specific selection rules. The azimuthal quantum numbers of the initial and final states must differ by unity while the electron's axial wave number is conserved. The azimuthal magnetic field is also found to lift the multiple degeneracies of the k z ≠0 interaction integrals as well as those of the oscillator strengths for optical transitions

  13. True Versus Spurious State Dependence in Firm Performance

    DEFF Research Database (Denmark)

    Kaiser, Ulrich; Kongsted, Hans Christian

    This paper analyzes the persistence of firms' exporting behavior in a panel of German manufacturing firms using dynamic binary choice models. We distinguish between true and spurious state dependence in exports and apply fixed effects methods that allow us to verify the robustness of our results ...... determinants. Our results, which are consistent with the findings of previous studies on firms in developing countries and in the United States, show the presence of important sunk costs in export market entry and a depreciation of knowledge and experience in export markets...

  14. True versus spurious state dependence in firm performance

    DEFF Research Database (Denmark)

    Kaiser, Ulrich; Kongsted, Hans Christian

    2008-01-01

    This paper analyzes the persistence of firms' exporting behavior in a panel of German manufacturing firms using dynamic binary choice models. We distinguish between true and spurious state dependence in exports and apply fixed effects methods that allow us to verify the robustness of our results ...... determinants. Our results, which are consistent with the findings of previous studies on firms in developing countries and in the United States, show the presence of important sunk costs in export market entry and a depreciation of knowledge and experience in export markets....

  15. Dependence of the Spin Transfer Torque Switching Current Density on the Exchange Stiffness Constant

    OpenAIRE

    You, Chun-Yeol

    2012-01-01

    We investigate the dependence of the switching current density on the exchange stiffness constant in the spin transfer torque magnetic tunneling junction structure with micromagnetic simulations. Since the widely accepted analytic expression of the switching current density is based on the macro-spin model, there is no dependence of the exchange stiffness constant. When the switching is occurred, however, the spin configuration forms C-, S-type, or complicated domain structures. Since the spi...

  16. Magnetic field dependence of the critical superconducting current induced by the proximity effect in silicon

    International Nuclear Information System (INIS)

    Nishino, T.; Kawabe, U.; Yamada, E.

    1986-01-01

    The magnetic field dependence of the critical superconducting current induced by the proximity effect in heavily-boron-doped Si is studied experimentally. It is found that the critical current flowing through the p-type-Si-coupled junction decreases with increasing applied magnetic field. The critical current can be expressed as the product of three factors: the current induced by de Gennes's proximity effect, the exponential decrease due to pair breaking by the magnetic field, and the usual diffraction-pattern-like dependence on the magnetic field due to the Josephson effect. The second factor depends on the carrier concentration in the semiconductor. The local critical current shows a rapid decrease at the edge of the electrodes

  17. Microbial production of hyaluronic acid: current state, challenges, and perspectives

    Directory of Open Access Journals (Sweden)

    Liu Long

    2011-11-01

    Full Text Available Abstract Hyaluronic acid (HA is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.

  18. Radical Islam in Xinjiang – Evolution and Current State

    Directory of Open Access Journals (Sweden)

    Jiri Suchanek

    2012-06-01

    Full Text Available The article analyses the evolution and the current state of radical Islam in China’s Xinjiang Uyghur Autonomous Region. Chinese government considers Islamic radicalism as a serious threat, in particular in the Xinjiang region, which borders on some states in Central Asia as well as Pakistan and Afghanistan. The purpose of this article is to describe and evaluate roots and historical development of significant groups, in particular the East Turkestan Islamic Movement – ETIM. In its next part, the article deals with the contemporary situation as well as the cooperation between Uyghur radicals and other radical Islamic movements, in particular al-Qaeda and Taliban, and their activities. The article concludes that contemporary Uyghur Islamic radicalism cannot be considered as a major security threat, since the activities of these groups have largely shifted to Pakistan and rather have the nature of a propaganda war.

  19. Pharmacovigilance in Russia: current state of affairs, challenges, and prospects.

    Science.gov (United States)

    Gildeeva, Geliya; Belostotsky, Andrey

    2017-12-01

    This review outlines current issues of the pharmacovigilance (PV) system in the Russian Federation, namely the present state of regulatory aspects, regulatory requirements in both Russia and the Eurasian Economic Union, and review of causes of under-reporting of adverse drug reactions. Specific attention will be focused on how the system is designed to monitor drug safety functions, reporting and accountability of pharmaceutical products, their manufacturers and medical staff, the role played by regional centers for drug-safety monitoring, and insufficient understanding of the part taken by patients in the system of PV. The prospects of the Russian PV system and its harmonization with global practice will also be discussed.

  20. The evolution and current state of emergency care in Ghana

    Directory of Open Access Journals (Sweden)

    Maxwell Osei-Ampofo

    2013-06-01

    Full Text Available Emergency Medicine as a specialty has only recently been introduced to Ghana. This article reviews the overall health and medical care systems as well as the evolution and the current state of emergency care in Ghana and the progress made in establishing Emergency Medicine (EM as a specialty along the Anglo-American model of emergency care. The article also describes the improvements implemented in emergency patient care, and emergency medicine management systems. Although there are challenges to overcome, much optimism remains about the future of this new specialty in Ghana and its ability to transform the face of emergency care.

  1. [Infection for papillomavirus in the man. Current state].

    Science.gov (United States)

    Gómez García, I; Gómez Mampaso, E; Conde Someso, S; Maganto Pavón, E; Navío Niño, S; Allona Almagro, A

    2005-04-01

    The Virus of the Human Papiloma (HPV), classically he/she has been related with infections of sexual transmission and processes wicked oncologists of the feminine genital apparatus and with less frequency of the masculine one. The new technical diagnostics, based on molecular biology (by means of polymerase chain reaction), they help to a better epidemic approach, an improvement in the I diagnose viral, and a correct therapeutic focus. The object of this work is to revise the current state of the HPV from the points of view etiopathogenics, epidemic, clinical, diagnosis, therapeutic and preservative.

  2. Cognitive Distortions in Depressed Women: Trait, or State Dependent?

    Directory of Open Access Journals (Sweden)

    Sedat BATMAZ

    2015-12-01

    Conclusion: The results have revealed that self-criticism, helplessness, hopelessness and preoccupation with danger related distortions had trait-like features, whereas self-blame related distortions were state dependent. This has clinical implications for the psychotherapeutic treatment of cognitive distortions in depression. Specifically, self-criticism related distortions should be managed during cognitive therapy for depression since the other subscales seem rather problematic. [JCBPR 2015; 4(3.000: 147-152

  3. Parameter dependence and outcome dependence in dynamical models for state vector reduction

    International Nuclear Information System (INIS)

    Ghirardi, G.C.; Grassi, R.; Butterfield, J.; Fleming, G.N.

    1993-01-01

    The authors apply the distinction between parameter independence and outcome independence to the linear and nonlinear models of a recent nonrelativistic theory of continuous state vector reduction. It is shown that in the nonlinear model there is a set of realizations of the stochastic process that drives the state vector reduction for which parameter independence is violated for parallel spin components in the EPR-Bohm setup. Such a set has an appreciable probability of occurrence (∼ 1/2). On the other hand, the linear model exhibits only extremely small parameter dependence effects. Some specific features of the models are investigated and it is recalled that, as has been pointed out recently, to be able to speak of definite outcomes (or equivalently of possessed objective elements of reality) at finite times, the criteria for their attribution to physical systems must be slightly changed. The concluding section is devoted to a detailed discussion of the difficulties met when attempting to take, as a starting point for the formulation of a relativistic theory, a nonrelativistic scheme which exhibits parameter dependence. Here the authors derive a theorem which identifies the precise sense in which the occurrence of parameter dependence forbids a genuinely relativistic generalization. Finally, the authors show how the appreciable parameter dependence of the nonlinear model gives rise to problems with relativity, while the extremely weak parameter dependence of the linear model does not give rise to any difficulty, provided the appropriate criteria for the attribution of definite outcomes are taken into account. 19 refs

  4. Gene-environment interactions and alcohol use and dependence: current status and future challenges

    NARCIS (Netherlands)

    Zwaluw, C.S. van der; Engels, R.C.M.E.

    2009-01-01

    To discuss the current status of gene-environment interaction research with regard to alcohol use and dependence. Further, we highlight the difficulties concerning gene-environment studies. Overview of the current evidence for gene-environment interactions in alcohol outcomes, and of the associated

  5. Cocaine induces state-dependent learning of sexual conditioning in male Japanese quail.

    Science.gov (United States)

    Gill, Karin E; Rice, Beth Ann; Akins, Chana K

    2015-01-01

    State dependent learning effects have been widely studied in a variety of drugs of abuse. However, they have yet to be studied in relation to sexual motivation. The current study investigated state-dependent learning effects of cocaine in male Japanese quail (Coturnix japonica) using a sexual conditioning paradigm. Cocaine-induced state-dependent learning effects were investigated using a 2×2 factorial design with training state as one factor and test state as the other factor. During a 14-day training phase, male quail were injected once daily with 10mg/kg cocaine or saline and then placed in a test chamber after 15min. In the test chamber, sexual conditioning trials consisted of presentation of a light conditioned stimulus (CS) followed by sexual reinforcement. During the state dependent test, half of the birds received a shift in drug state from training to testing (Coc→Sal or Sal→Coc) while the other half remained in the same drug state (Coc→Coc or Sal→Sal). Results showed that male quail that were trained and tested in the same state (Coc→Coc or Sal→Sal) showed greater sexual conditioning than male quail that were trained and tested in different states (Sal→Coc) except when cocaine was administered chronically prior to the test (Coc→Sal). For the latter condition, sexual conditioning persisted from cocaine training to the saline test. The findings suggest that state dependent effects may alter sexual motivation and that repeated exposure to cocaine during sexual activity may increase sexual motivation which, in turn, may lead to high risk sexual activities. An alternative explanation for the findings is also discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Frequency-dependent Lg Q within the continental United States

    Science.gov (United States)

    Erickson, D.; McNamara, D.E.; Benz, H.M.

    2004-01-01

    Frequency-dependent crustal attenuation (1/Q) is determined for seven distinct physiographic/tectonic regions of the continental United States using high-quality Lg waveforms recorded on broadband stations in the frequency band 0.5 to 16 Hz. Lg attenuation is determined from time-domain amplitude measurements in one-octave frequency bands centered on the frequencies 0.75, 1.0, 3.0, 6.0, and 12.0 Hz. Modeling errors are determined using a delete-j jackknife resampling technique. The frequency-dependent quality factor is modeled in the form of Q = Q0 fη. Regions were initially selected based on tectonic provinces but were eventually limited and adjusted to maximize ray path coverage in each area. Earthquake data was recorded on several different networks and constrained to events occurring within the crust (decomposition inversion technique was applied to the data to simultaneously solve for source and receiver terms along with Q for each region at specific frequencies. The lowest crustal Q was observed in northern and southern California where Q is described by the functions Q = 152(±37)f0.72(±0.16) and Q = 105(±26)f0.67(±0.16), respectively. The Basin and Range Province, Pacific Northwest, and Rocky Mountain states also display lower Q and a strong frequency dependence characterized by the functions Q = 200(±40)f0.68(±0.12), Q = 152(±49)f0.76(±0.18), and Q = 166(±37)f0.61(±0.14), respectively. In contrast, in the central and northeast United States Q functions are Q = 640(±225)f0.344(±0.22) and Q = 650(±143)f0.36(±0.14), respectively, show a high crustal Q and a weaker frequency dependence. These results improve upon previous Lg modeling by subdividing the United States into smaller, distinct tectonic regions and using significantly more data that provide improved constraints on frequency-dependent attenuation and errors. A detailed attenuation map of the continental United States can provide significant input into hazard map mitigation. Both

  7. Complexity and state-transitions in social dependence networks

    Directory of Open Access Journals (Sweden)

    Giuliano Pistolesi

    2001-01-01

    Full Text Available Computation of complexity in Social Dependence Networks is an interesting research domain to understand evolution processes and group exchange dynamics in natural and artificial intelligent Multi-Agent Systems. We perform an agent-based simulation by NET-PLEX (Conte and Pistolesi, 2000, a new software system able both to build interdependence networks tipically emerging in Multi-Agent System scenarios and to investigate complexity phenomena, i.e., unstability and state-transitions like Hopf bifurcation (Nowak and Lewenstein, 1994, and to describe social self organization phenomena emerging in these artificial social systems by means of complexity measures similar to those introduced by Hubermann and Hogg (1986. By performing analysis of complexity in these kind of artificial societies we observed interesting phenomena in emerging organizations that suggest state-transitions induced by critical configurations of parameters describing the social system similar to those observed in many studies on state-transitions in bifurcation chaos (Schuster, 1988; Ruelle, 1989.

  8. The United States facing their petroleum dependence; Les Etats-Unis face a leur dependance petroliere

    Energy Technology Data Exchange (ETDEWEB)

    Noel, P. [Institut francais des Relations Internationals, 75 - Paris (France); Universite Pierre Mendes-France-IEPE-CNRS, 38 - Grenoble (France)

    2002-06-01

    In the framework of ''the energy crisis of 2000-2001'', the Cheney report and the petroleum dependence, this study presents a critical examination of the United States petroleum situation, its perception in the american political milieu and the public policies implementing during the last ten years. The first section is devoted to the petroleum supply. In the second section, the american petroleum policy and the energy safety are studied. (A.L.B.)

  9. The tunneling magnetoresistance current dependence on cross sectional area, angle and temperature

    Directory of Open Access Journals (Sweden)

    Z. H. Zhang

    2015-03-01

    Full Text Available The magnetoresistance of a MgO-based magnetic tunnel junction (MTJ was studied experimentally. The magnetoresistance as a function of current was measured systematically on MTJs for various MgO cross sectional areas and at various temperatures from 7.5 to 290.1 K. The resistance current dependence of the MTJ was also measured for different angles between the two ferromagnetic layers. By considering particle and angular momentum conservation of transport electrons, the current dependence of magnetoresistance can be explained by the changing of spin polarization in the free magnetic layer of the MTJ. The changing of spin polarization is related to the magnetoresistance, its angular dependence and the threshold current where TMR ratio equals zero. A phenomenological model is used which avoid the complicated barrier details and also describes the data.

  10. THE CURRENT STATE OF CLOTHING TRADE IN THE BALKAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    TRIPA Simona

    2017-05-01

    Full Text Available The study presented here is aimed at analysing the current state of clothing trade in the Balkan states. The dynamics of change over a 15‐year period following economic reforms are revealed. The clothing industries play a significant role and continue to contribute to the economic prosperity of countries with an inexpensive labour force. For most Balkan States clothing’s export plays an important role in promoting economic growth and development – for example, exports of garments Albania was in 2015, 16.81% of its exports, Republic of Macedonia 11.75% of its exports, in Turkey10.51% etc. The main factors which influence the level of competitiveness of clothing products from the Balkans are the gross value added per employee and wages. When the producers of the Balkan countries will create products with higher added value in garment industry the competitiveness of these countries will decrease. Also rising wages in this industry, as a result of trade union pressure or government policy, will lead to decreasing competitiveness of these products on the EU market and implicitly to the decrease of exports of garments from these countries. The main challenges that must face the Balkan States are related to restructuring of economic system, changing trade markets and patterns, declining of domestic demand of most merchandise, reduction of competitive ability, narrow export base, and lower economies of scale. The main opportunities that most of these countries can exploit are related to their geographical position, membership of the EU market, infrastructure in garment sector, and highly skilled workforce.

  11. State-dependent architecture of thalamic reticular subnetworks.

    Science.gov (United States)

    Halassa, Michael M; Chen, Zhe; Wimmer, Ralf D; Brunetti, Philip M; Zhao, Shengli; Zikopoulos, Basilis; Wang, Fan; Brown, Emery N; Wilson, Matthew A

    2014-08-14

    Behavioral state is known to influence interactions between thalamus and cortex, which are important for sensation, action, and cognition. The thalamic reticular nucleus (TRN) is hypothesized to regulate thalamo-cortical interactions, but the underlying functional architecture of this process and its state dependence are unknown. By combining the first TRN ensemble recording with psychophysics and connectivity-based optogenetic tagging, we found reticular circuits to be composed of distinct subnetworks. While activity of limbic-projecting TRN neurons positively correlates with arousal, sensory-projecting neurons participate in spindles and show elevated synchrony by slow waves during sleep. Sensory-projecting neurons are suppressed by attentional states, demonstrating that their gating of thalamo-cortical interactions is matched to behavioral state. Bidirectional manipulation of attentional performance was achieved through subnetwork-specific optogenetic stimulation. Together, our findings provide evidence for differential inhibition of thalamic nuclei across brain states, where the TRN separately controls external sensory and internal limbic processing facilitating normal cognitive function. PAPERFLICK: Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Volume dependence of N-body bound states

    Science.gov (United States)

    König, Sebastian; Lee, Dean

    2018-04-01

    We derive the finite-volume correction to the binding energy of an N-particle quantum bound state in a cubic periodic volume. Our results are applicable to bound states with arbitrary composition and total angular momentum, and in any number of spatial dimensions. The only assumptions are that the interactions have finite range. The finite-volume correction is a sum of contributions from all possible breakup channels. In the case where the separation is into two bound clusters, our result gives the leading volume dependence up to exponentially small corrections. If the separation is into three or more clusters, there is a power-law factor that is beyond the scope of this work, however our result again determines the leading exponential dependence. We also present two independent methods that use finite-volume data to determine asymptotic normalization coefficients. The coefficients are useful to determine low-energy capture reactions into weakly bound states relevant for nuclear astrophysics. Using the techniques introduced here, one can even extract the infinite-volume energy limit using data from a single-volume calculation. The derived relations are tested using several exactly solvable systems and numerical examples. We anticipate immediate applications to lattice calculations of hadronic, nuclear, and cold atomic systems.

  13. Hysteresis loops of spin-dependent electronic current in a paramagnetic resonant tunnelling diode

    International Nuclear Information System (INIS)

    Wójcik, P; Spisak, B J; Wołoszyn, M; Adamowski, J

    2012-01-01

    Nonlinear properties of the spin-dependent electronic transport through a semiconductor resonant tunnelling diode with a paramagnetic quantum well are considered. The spin-dependent Wigner–Poisson model of the electronic transport and the two-current Mott’s formula for the independent spin channels are applied to determine the current–voltage curves of the nanodevice. Two types of the electronic current hysteresis loops are found in the current–voltage characteristics for both the spin components of the electronic current. The physical interpretation of these two types of the electronic current hysteresis loops is given based on the analysis of the spin-dependent electron densities and the potential energy profiles. The differences between the current–voltage characteristics for both the spin components of the electronic current allow us to explore the changes of the spin polarization of the current for different electric fields and determine the influence of the electronic current hysteresis on the spin polarization of the current flowing through the paramagnetic resonant tunnelling diode. (paper)

  14. Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle.

    Science.gov (United States)

    Masukawa, L M; Albuquerque, E X

    1978-09-01

    Histrionicotoxin, a toxin isolated from skin secretions of a Colombian arrow poison frog, Dendrobates histrionicus, decreased the amplitude and time-course of the endplate current, and altered the voltage dependence of the half-decay time. In addition, the toxin produced a characteristic nonlinearity in the current-voltage relationship of the endplate current when 3-s voltage conditioning steps were used. Reduction in time of the conditioning steps to 10 ms made the current-voltage relationship linear. The decrease in peak amplitude of the endplate current (epc) produced by histrionicotoxin measured during long hyperpolarizing conditioning steps was fitted by a single exponential function. The calculated rate constants ranged from 0.03 to 0.14 s-1 and varied with membrane potential at hyperpolarizing levels. The voltage- and time-dependent action of histrionicotoxin does not require an initial activation of receptors by acetylcholine (ACh). The characteristic of the current-voltage relationship can be accounted for by the observed voltage and time dependency of the attenuation of the endplate current amplitude in the presence of histrionicotoxin during long conditioning steps. These effects of histrionicotoxin on the peak amplitude, and on the voltage and time dependence of the epc were concentration-dependent and slowly reversible upon washing out the toxin. Thus, the voltage- and time-dependent action of histrionicotoxin at the endplate is related to an increase in the affinity between the toxin and the ACh receptor-ionic channel complex. This increase in affinity is postulated to be due to a conformational change of the macromolecule in the presence of histrionicotoxin which is demonstrated to be relatively slow, i.e., on the order of tens of seconds.

  15. Imaging of lumbar degenerative disk disease: history and current state

    International Nuclear Information System (INIS)

    Emch, Todd M.; Modic, Michael T.

    2011-01-01

    One of the most common indications for performing magnetic resonance (MR) imaging of the lumbar spine is the symptom complex thought to originate as a result of degenerative disk disease. MR imaging, which has emerged as perhaps the modality of choice for imaging degenerative disk disease, can readily demonstrate disk pathology, degenerative endplate changes, facet and ligamentous hypertrophic changes, and the sequelae of instability. Its role in terms of predicting natural history of low back pain, identifying causality, or offering prognostic information is unclear. As available modalities for imaging the spine have progressed from radiography, myelography, and computed tomography to MR imaging, there have also been advances in spine surgery for degenerative disk disease. These advances are described in a temporal context for historical purposes with a focus on MR imaging's history and current state. (orig.)

  16. Development and current state of dosimetry in Cuba

    International Nuclear Information System (INIS)

    Prieto Miranda, E.F.; Cuesta Fuente, G.; Chavez Ardanza, A.

    1999-01-01

    In Cuba, the application of the radiation technologies has been growing in the last years, and at present there are several dosimetry systems with different ranges of absorbed dose. Diverse researches were carried out on high dose dosimetry with the following dosimetry systems: Fricke, ceric-cerous sulfate, ethanol-chlorobenzene, cupric sulfate and Perspex (Red 4034 AE and Clear HX). In this paper the development achieved during the last 15 years in the high dose dosimetry for radiation processing in Cuba is presented, as well as, the current state of different dosimetry systems employed for standardization and for process control. The paper also reports the results of dosimetry intercomparison studies that were performed with the Ezeiza Atomic Center of Argentine and the International Dose Assurance Service (IDAS) of IAEA. (author)

  17. The current state of industry development in Ukraine: advance perspective

    Directory of Open Access Journals (Sweden)

    Skyba Maryna Valeriyivna

    2015-02-01

    Full Text Available The current state of the industry of Ukraine are considered at the article. The author determined that the stabilization of the situation and further development of the industry need first of all cessation of hostilities. It is necessary to implement effective measures to combat corruption, the development of consistent, constructive and concerted action on the formation of institutions guaranteeing stability, predictability and transparency of the market rules and procedures that minimize the impact of shadow factors, and implementation of professional privatization and limitation of monopoly at the markets, forming a transparent, competitive business environment, the introduction of new energy saving technologies. These measures will help attract investment, increase production and improve enterprise profitability.

  18. Current state of genome-scale modeling in filamentous fungi

    DEFF Research Database (Denmark)

    Brandl, Julian; Andersen, Mikael Rørdam

    2015-01-01

    capacity. One of the major bottlenecks in the development of new strains into viable industrial hosts is the alteration of the metabolism towards optimal production. Genome-scale models promise a reduction in the time needed for metabolic engineering by predicting the most potent targets in silico before...... testing them in vivo. The increasing availability of high quality models and molecular biological tools for manipulating filamentous fungi renders the model-guided engineering of these fungal factories possible with comprehensive metabolic networks. A typical fungal model contains on average 1138 unique...... metabolic reactions and 1050 ORFs, making them a vast knowledge-base of fungal metabolism. In the present review we focus on the current state as well as potential future applications of genome-scale models in filamentous fungi....

  19. Transresistance calibrations and temperature dependence evaluation of a magnetic bridge current sensor with shunt standards

    International Nuclear Information System (INIS)

    Yamada, T; Kon, S; Tadatsu, T

    2011-01-01

    This paper deals with a magnetic bridge current sensor for dc current measurements and a calibration system developed for the current sensor. The current sensor forms a magnetic bridge structure with a magnetic fluid core. The calibration system has been developed by using standard shunts for a test current range of 1 mA to 100 A and establishing a comparison method with a switching/sampling system. In the calibration system, the transresistances of the current sensor are measured and the uncertainties of the system are estimated for the input test current range. Also, the temperature dependence on the transresistances is investigated for temperatures ranging from −40 to 100 °C

  20. Quantum phases in tunable state-dependent hexagonal optical lattices

    Science.gov (United States)

    Lühmann, Dirk-Sören; Jürgensen, Ole; Weinberg, Malte; Simonet, Juliette; Soltan-Panahi, Parvis; Sengstock, Klaus

    2014-07-01

    We study the ground-state properties of ultracold bosonic atoms in a state-dependent graphenelike honeycomb optical lattice, where the degeneracy between the two triangular sublattices A and B can be lifted. We discuss the various geometries accessible with this lattice setup and present a scheme to control the energy offset with external magnetic fields. The competition of the on-site interaction with the offset energy leads to Mott phases characterized by population imbalances between the sublattices. For the definition of an optimal Hubbard model, we demonstrate a scheme that allows for the efficient computation of Wannier functions. Using a cluster mean-field method, we compute the phase diagrams and provide a universal representation for arbitrary energy offsets. We find good agreement with the experimental data for the superfluid to Mott insulator transition.

  1. The problem of dependency: immigration, gender, and the welfare state.

    Science.gov (United States)

    Eggebø, Helga

    2010-01-01

    This article discusses the regulation of marriage migration to Norway through an analysis of the subsistence requirement rule which entails that a person who wants to bring a spouse to Norway must achieve a certain level of income. Policy-makers present two main arguments for this regulation. First, the subsistence requirement is a means to prevent forced marriage. Second, its aim is to prevent family immigrants from becoming a burden on welfare budgets. The major concern of both these arguments is that of dependency, either on the family or on the welfare state. The article investigates the representations of the “problems” underpinning this specific policy proposal and argues that the rule in question, and immigration policy more generally, needs to be analyzed with reference to the broader concerns and aims of welfare state policy and gender equality policy.

  2. Enceladus: three-act play and current state

    Science.gov (United States)

    Luan, J.; Goldreich, P.

    2017-12-01

    Eccentricity (e) growth as Enceladus migrates deeper into mean motion resonance with Dione results in increased tidal heating. As the bottom of the ice shell melts, the rate of tidal heating jumps and runaway melting ensues. At the end of run-away melting, the shell's thickness has fallen below the value at which the frequency of free libration equals the orbital mean motion and e has damped to well below its current value. Subsequently, both the shell thickness and e partake in a limit cycle. As e damps toward its minimum value, the shell's thickness asymptotically approaches its resonant value from below. After minimum e, the shell thickens quickly and e grows even faster. This cycle is likely to have been repeated multiple times in the past. Currently, e is much smaller than its equilibrium value corresponding to the shell thickness. Physical libration resonance resolves this mystery, it ensures that the low-e and medium-thickness state is present for most of the time between consecutive limit cycles. It is a robust scenario that avoids fine tuning or extreme parameter choice, and naturally produces episodic stages of high heating, consistent with softening of topographical features on Enceladus.

  3. ["Good dying"--definition and current state of research].

    Science.gov (United States)

    Hutter, Nico; Stößel, Ulrich; Meffert, Cornelia; Körner, Mirjam; Bozzaro, Claudia; Becker, Gerhild; Baumeister, Harald

    2015-08-01

    The advances of modern medicine did not only result in prolongation of life expectancy, but also led to a shift from dying at home to dying in public institutions. In western countries most people die at advanced age in medical facilities. Hence, the question regarding the conditions, which should be provided by society and especially medicine, to allow terminally ill people to experience "good dying" is substantial. For this purpose, an examination of patients', family members' and health care providers' understanding of the term " good dying" is required. The present paper aims at shedding light on the term "good dying" and to summarize the current state of research. Therefore, the attributes of "good dying" will be described from the perspectives of patients, family members and health care providers, which are discussed and examined in current medical-sociological research. These attributes can be illustrated on three dimensions: Quality of life at the end of life (e. g. pain relief, mental well-being), quality of dying (e. g. avoiding prolonged dying, autonomy, presence of relatives) and quality of health care at the end of life (e. g. patient-oriented health care, positive communication between health care providers and patients, availability of guidelines). Although the attributes of "good dying" are described in detail in the existing literature, further studies have to clarify the relevance and impact of these attributes as predictors of "good dying". © Georg Thieme Verlag KG Stuttgart · New York.

  4. Resting-state abnormalities in heroin-dependent individuals.

    Science.gov (United States)

    Pandria, Niki; Kovatsi, Leda; Vivas, Ana B; Bamidis, Panagiotis D

    2016-11-21

    Drug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific prefrontal, parietal, occipital, and temporal regions, as well as, some subcortical regions. The brain regions involved are usually linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control and seem to form circuits that interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively review and discuss existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapy a multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  5. Critical current characteristics and history dependence in superconducting SmFeAsOF bulk

    International Nuclear Information System (INIS)

    Ni, B; Ge, J; Kiuchi, M; Otabe, E S; Gao, Z; Wang, L; Qi, Y; Zhang, X; Ma, Y

    2010-01-01

    The superconducting SmFeAsO 1-x F x (x=0.2) polycrystalline bulks were prepared by the powder-in-tube (PIT) method. The magnetic field and temperature dependences of critical current densities in the samples were investigated by resistive and ac inductive (Campbell's) methods. It was found that a fairly large shielding current density over 10 9 A/m 2 , which is considered to correspond to the local critical current density, flows locally with the perimeter size similar to the average grain size of the bulk samples, while an extremely low transport current density of about 10 5 A/m 2 corresponding to the global critical current density flows through the whole sample. Furthermore, a unique history dependence of global critical current density was observed, i.e., it shows a smaller value in the increasing-field process than that in the decreasing-field process. The history dependence of global critical current characteristic in our case can be ascribed to the existence of the weak-link property between the grains in SmFeAsO 1-x F x bulk.

  6. Public Administration: Modernizing The Current Model Of State Management

    Directory of Open Access Journals (Sweden)

    Evgenii V. Ohotskii

    2014-01-01

    Full Text Available Applying the method of retrospective analysis the article deals with the process of forming the scientific fundamentals and the search by the international community of effective and adequate to the current stage of social development public administration system. The author attempts to analyze, in a number of cases in terms of models, features of public administration systems at different stages of historical development, drawing attention to reasons why the Soviet model of public administration did not manage to meet competition, did not provide the required social effect and as a natural result suffered a defeat in the global confrontation between the two social systems. Current models and theoretical concepts of public administration, especially the "new public administration", which became scientific basis for administrative reforms implemented in many countries, are the particular subject of scientific analysis. The author draws attention to major comprehensive characteristics of modern state public administration: making it impossible to absolutize principles of traditional hierarchy system of forced administration; globalization - gradual destruction of boundaries between national and international levels of administration, the growing role of supranational subjects of administration relations; informatization - increasing importance of information and communication technologies and of political networks: development of civil society, especially political parties and non-governmental organizations, growing public involvement in discussion and adoption of the most important administrative decisions; making the state policy more pluralistic and which will result in the formation of nonlinear - humanistic social consciousness as the intellectual basis of modern social governance. The author's position is that Russia is yet to solve the issue of choosing a public administration model that would be effective for further administrative

  7. PUBLIC ADMINISTRATION: MODERNIZING THE CURRENT MODEL OF STATE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Evgenii V. Ohotskii

    2014-01-01

    Full Text Available Applying the method of retrospective analysis the article deals with the process of forming the scientific fundamentals and the search by the international community of effective and adequate to the current stage of social development public administration system. The author attempts to analyze, in a number of cases in terms of models, features of public administration systems at different stages of historical development, drawing attention to reasons why the Soviet model of public administration did not manage to meet competition, did not provide the required social effect and as a natural result suffered a defeat in the global confrontation between the two social systems. Current models and theoretical concepts of public administration, especially the "new public administration", which became scientific basis for administrative reforms implemented in many countries, are the particular subject of scientific analysis. The author draws attention to major comprehensive characteristics of modern state public administration: making it impossible to absolutize principles of traditional hierarchy system of forced administration; globalization - gradual destruction of boundaries between national and international levels of administration, the growing role of supranational subjects of administration relations; informatization - increasing importance of information and communication technologies and of political networks: development of civil society, especially political parties and non-governmental organizations, growing public involvement in discussion and adoption of the most important administrative decisions; making the state policy more pluralistic and which will result in the formation of nonlinear - humanistic social consciousness as the intellectual basis of modern social governance. The author's position is that Russia is yet to solve the issue of choosing a public administration model that would be effective for further administrative

  8. Dependence of critical current density on crystalline direction in thin YBCO films

    DEFF Research Database (Denmark)

    Paturi, P.; Peurla, M.; Raittila, J.

    2005-01-01

    The dependence of critical current density (J(c)) on the angle between the current direction and the (100) direction in the ab-plane of thin YBCO films deposited on (001)-SrTiO3 from natiocrystalline and microcrystalline targets is studied using magneto-optical microscopy. In the films made from...... the nanocrystalline target it is found that J(c) does not depend on the angle whereas J(c) decreases with increasing angle in the films made from the microcrystalline target. The films were characterized by detailed X-ray diffraction measurements. The findings are explained in terms of a network of planar defects...

  9. The current state of serum biomarkers of hepatotoxicity.

    Science.gov (United States)

    Ozer, Josef; Ratner, Marcia; Shaw, Martin; Bailey, Wendy; Schomaker, Shelli

    2008-03-20

    The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, indicating that the enzyme has specificity beyond liver in the absence of correlative histomorphologic alteration in liver. Thus, unidentified non-hepatic sources of serum ALT activity may inadvertently influence the decision of whether to continue development of a novel pharmaceutical compound. To assess the risk of false positives due to extraneous sources of serum ALT activity, additional biomarkers are sought with improved specificity for liver function compared to serum ALT activity alone. Current published biomarker candidates are reviewed herein and compared with ALT performance in preclinical and on occasion, clinical studies. An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GSTalpha) levels, all measured by ELISA, may show utility, however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies. In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values. Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in

  10. The current state of serum biomarkers of hepatotoxicity

    International Nuclear Information System (INIS)

    Ozer, Josef; Ratner, Marcia; Shaw, Martin; Bailey, Wendy; Schomaker, Shelli

    2008-01-01

    The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, indicating that the enzyme has specificity beyond liver in the absence of correlative histomorphologic alteration in liver. Thus, unidentified non-hepatic sources of serum ALT activity may inadvertently influence the decision of whether to continue development of a novel pharmaceutical compound. To assess the risk of false positives due to extraneous sources of serum ALT activity, additional biomarkers are sought with improved specificity for liver function compared to serum ALT activity alone. Current published biomarker candidates are reviewed herein and compared with ALT performance in preclinical and on occasion, clinical studies. An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GSTα) levels, all measured by ELISA, may show utility, however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies. In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values. Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging markers to monitor acute drug-induced liver injury in early

  11. Transcatheter Pulmonary Valve Replacement: Current State of Art.

    Science.gov (United States)

    Alkashkari, Wail; Alsubei, Amani; Hijazi, Ziyad M

    2018-03-15

    The past couple of decades have brought tremendous advances to the field of pediatric and adult congenital heart disease (CHD). Percutaneous valve interventions are now a cornerstone of not just the congenital cardiologist treating patients with congenital heart disease, but also-and numerically more importantly-for adult interventional cardiologists treating patients with acquired heart valve disease. Transcatheter pulmonary valve replacement (tPVR) is one of the most exciting recent developments in the treatment of CHD and has evolved to become an attractive alternative to surgery in patients with right ventricular outflow tract (RVOT) dysfunction. This review aims to summarize (1) the current state of the art for tPVR, (2) the expanding indications, and (3) the technological obstacles to optimizing tPVR. Since its introduction in 2000, more than ten thousands tPVR procedures have been performed worldwide. Although the indications for tPVR have been adapted earlier from those accepted for surgical intervention, they remain incompletely defined. The new imaging modalities give better assessment of cardiac anatomy and function and determine candidacy for the procedure. The procedure has been shown to be feasible and safe when performed in patients who received pulmonary conduit and or bioprosthetic valves between the right ventricle and the pulmonary artery. Fewer selected patients post trans-annular patch repair for tetralogy of Fallot may also be candidates for this technology. Size restrictions of the currently available valves limit deployment in the majority of patients post trans-annular patch repair. Newer valves and techniques are being developed that may help such patients. Refinements and further developments of this procedure hold promise for the extension of this technology to other patient populations.

  12. The Current State of Critical Limb Ischemia: A Systematic Review.

    Science.gov (United States)

    Farber, Alik; Eberhardt, Robert T

    2016-11-01

    Chronic critical limb ischemia, marked by intractable lower extremity ischemic rest pain and tissue loss, is a highly morbid condition that leads to the loss of ambulation and decreased quality of life. It is associated with a high risk of limb loss and mortality and presents a significant economic burden to society. To review the current state of epidemiology, pathophysiology, diagnosis, and treatment of critical limb ischemia. An extensive literature search of the subject matter was conducted on material published in English between 1980 and 2016; both landmark and recently published articles were evaluated. Articles were reviewed if they included the terms critical limb ischemia, ischemic rest pain, gangrene, or extremity ulcers. Critical limb ischemia represents the end stage of peripheral arterial disease. Because peripheral arterial disease is most commonly caused by atherosclerosis, critical limb ischemia is heavily associated with smoking and diabetes. Revascularization is the cornerstone of therapy to prevent limb amputation, and both open vascular surgery and endovascular therapy play a key role in the treatment of patients with critical limb ischemia. However, few scientific data are available to identify the optimal revascularization strategy, which has led to a significant amount of variability and equipoise in the treatment of this condition. Medical therapy plays a significant role in optimizing coexistent cardiovascular risk factors and a limited role in improving limb outcomes in nonrevascularizable disease. Understanding critical limb ischemia and its treatment strategies is important for providing the best care for affected patients. Currently, ongoing randomized clinical trials in North America and the United Kingdom aim to provide data to support the best management of these patients.

  13. CRIMEAN TATAR FACTOR IN CRIMEA: THE CURRENT STATE AND PROSPECTS

    Directory of Open Access Journals (Sweden)

    D. A. Merenkov

    2017-01-01

    Full Text Available The article deals with the current situation of the Crimean Tatars in Crimea after joining Russia. It is considered a number of decisions taken by Russia, which changed the life of this national minority. For example, according an official status to the Crimean-Tatar language or improving living conditions in Crimean Tatars-populated areas. The article highlights the creation of the Spiritual Administration of Muslims of Crimea. The author describes the renewal of the mass media in Crimea and the creation of the TV and Radio company Millet instead of the Ukrainian TV channel ATR. The author stresses the difference in the approaches of the Ukrainian and Russian authorities to the question of the deportation of the Crimean Tatars in 1944. The article touches upon the UN General Assembly resolution A / RES / 71/205, 19 December 2016. It is devoted to “Situation of human rights in the Autonomous Republic of Crimea and the city of Sevastopol (Ukraine”. The author offers to get acquainted with the opinion of the Crimean Tatars, who live in Crimea at present, about their current situation after the reunification of Crimea and Sevastopol with Russia. It is analyzed the Ukrainian authorities’ policy on the Crimean Tatars. The author notes the negative effect of the Ukrainian authorities on radical feelings in Crimea. The process of forming these sentiments is considered in the article. The author notes the increased military activities by the illegal armed groups of the Crimean Tatars in the Ukrainian part of the Russian-Ukrainian state boundary. The article emphasizes the evaluation of the Crimean Tatars’ influence on security and stability on the peninsula, as well as the prospects of it. The author gives recommendations on the establishment of inter-ethnic relations, and notes that there is a potential for further development of inter-ethnic dialogue. The author concludes that the Crimean Tatars can act as a stabilizing and destabilizing

  14. CALCULATED TEMPERATURE RISE AND THERMAL ELONGATION OF STRUCTURAL COMPONENTS, DEPENDING ON ACTION INTEGRAL OF INJECTED LIGHTNING CURRENTS

    DEFF Research Database (Denmark)

    Madsen, Søren Find

    2005-01-01

    In the initial phase of an aircraft design, it is valuable to be capable of predicting temperature rise and thermal elongation depending on the actual threat from lightning currents. In this paper equations are stated to calculate the temperature rise of different structures. The analytical...... expressions established, accounts for the geometry of the structure (round conductor, rectangular cross section, pipe, plane sheet, etc), the material properties (Aluminum, Copper, Carbon Fiber Composites, etc.), the frequency of the current (skin depth) and the Specific Energy (Action Integral). For linear...... structures (wires, bars etc.), the result is the resistance of the structure, the final temperature, and the thermal elongation depending on geometry and material properties. Regarding arc injection in the centre of plane specimens the equations enables calculation of the temperature as a function...

  15. Current state of hereditary angioedema management: A patient survey

    Science.gov (United States)

    Busse, Paula; Christiansen, Sandra C.; Li, Henry; Lumry, William; Davis-Lorton, Mark; Bernstein, Jonathan A.; Frank, Michael; Castaldo, Anthony; Long, Janet F.; Zuraw, Bruce L.; Riedl, Marc

    2015-01-01

    Hereditary angioedema (HAE) is a chronic disease with a high burden of disease that is poorly understood and often misdiagnosed. Availability of treatments, including C1 esterase inhibitor (C1INH) replacement, ecallantide, and icatibant, marks a significant advance for HAE patients. We aimed to better understand the current state of HAE care, from a patient perspective, after the introduction of several novel therapies. One session of the United States Hereditary Angioedema Association 2013 patient summit was devoted to data collection for this study. Patients attending the summit were self-selected, and HAE diagnosis was self-reported. Survey questions assessed patient characteristics, burden of disease, and treatment. Participant responses were captured using an audience response system. We surveyed 149 (80%) type I and II HAE (HAE-C1INH) and 37 (20%) HAE with normal C1INH (HAE-nlC1INH) patients. HAE-C1INH (72%) and HAE-nlCINH patients (76%) equally reported that HAE had a significant impact on quality of life (QOL). A third of HAE-C1INH patients were diagnosed within one year of their first HAE attack, but another third reported a delay of more than 10 years. Most HAE-C1INH (88%) and HAE-nlC1INH (76%) patients had on-demand treatment available. HAE-C1INH patients frequently had an individual treatment plan (76%) compared with 50% of HAE-nlC1INH patients. Most HAE-C1INH patients went to the emergency department (ED) or were hospitalized less than once every six months (80%). Our findings show that HAE management is improving with good access to on-demand and prophylactic treatment options. However, HAE patients still have a significant burden of disease and continued research and educational efforts are needed. PMID:25976438

  16. The current state of water resources of Transcarpathia

    Directory of Open Access Journals (Sweden)

    V. І. Nikolaichuk

    2015-07-01

    sanitary rules and regulations by the most of indicators of general health and specific indices. 19.0% of total water supply systems fail to meet the sanitary norms and regulations, in particular: 14.2% for the lack of sanitary protection zones; 1.9% because of unavailability of the necessary integrated treatment facilities, and 7.6% by the reason of absence of disinfecting plants. Possible ways of avoiding the depletion of water bodies are preventive water protection measures aimed at preventing or limiting pollution, water contamination and depletion; besides, it is necessary to educate people explaning them the current state and possible consequences of thoughtless water consumption.

  17. The Keldysh formalism applied to time-dependent current-density-functional theory

    NARCIS (Netherlands)

    Gidopoulos, NI; Wilson, S

    2003-01-01

    In this work we demonstrate how to derive the Kohn-Sham equations of time-dependent current-density functional theory from a generating action functional defined on a Keldysh time contour. These Kohn-Sham equations contain an exchange-correlation contribution to the vector potential. For this

  18. Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+current, Ca2+cycling, and excitability: a mathematical modeling study.

    Science.gov (United States)

    Onal, Birce; Gratz, Daniel; Hund, Thomas J

    2017-12-01

    Atrial fibrillation (AF) affects more than three million people per year in the United States and is associated with high morbidity and mortality. Both electrical and structural remodeling contribute to AF, but the molecular pathways underlying AF pathogenesis are not well understood. Recently, a role for Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) in the regulation of persistent "late" Na + current ( I Na,L ) has been identified. Although I Na,L inhibition is emerging as a potential antiarrhythmic strategy in patients with AF, little is known about the mechanism linking I Na,L to atrial arrhythmogenesis. A computational approach was used to test the hypothesis that increased CaMKII-activated I Na,L in atrial myocytes disrupts Ca 2+ homeostasis, promoting arrhythmogenic afterdepolarizations. Dynamic CaMKII activity and regulation of multiple downstream targets [ I Na,L , L-type Ca 2+ current, phospholamban, and the ryanodine receptor sarcoplasmic reticulum Ca 2+ -release channel (RyR2)] were incorporated into an existing well-validated computational model of the human atrial action potential. Model simulations showed that constitutive CaMKII-dependent phosphorylation of Na v 1.5 and the subsequent increase in I Na,L effectively disrupt intracellular atrial myocyte ion homeostasis and CaMKII signaling. Specifically, increased I Na,L promotes intracellular Ca 2+ overload via forward-mode Na + /Ca 2+ exchange activity, which greatly increases RyR2 open probability beyond that observed for CaMKII-dependent phosphorylation of RyR2 alone. Increased I Na,L promotes atrial myocyte repolarization defects (afterdepolarizations and alternans) in the setting of acute β-adrenergic stimulation. We anticipate that our modeling efforts will help identify new mechanisms for atrial Na V 1.5 regulation with direct relevance for human AF. NEW & NOTEWORTHY Here, we present a novel computational model to study the effects of late Na + current ( I Na,L ) in human atrial

  19. Computed tomography: acquisition process, technology and current state

    Directory of Open Access Journals (Sweden)

    Óscar Javier Espitia Mendoza

    2016-02-01

    Full Text Available Computed tomography is a noninvasive scan technique widely applied in areas such as medicine, industry, and geology. This technique allows the three-dimensional reconstruction of the internal structure of an object which is lighted with an X-rays source. The reconstruction is formed with two-dimensional cross-sectional images of the object. Each cross-sectional is obtained from measurements of physical phenomena, such as attenuation, dispersion, and diffraction of X-rays, as result of their interaction with the object. In general, measurements acquisition is performed with methods based on any of these phenomena and according to various architectures classified in generations. Furthermore, in response to the need to simulate acquisition systems for CT, software dedicated to this task has been developed. The objective of this research is to determine the current state of CT techniques, for this, a review of methods, different architectures used for the acquisition and some of its applications is presented. Additionally, results of simulations are presented. The main contributions of this work are the detailed description of acquisition methods and the presentation of the possible trends of the technique.

  20. Ebola hemorrhagic Fever and the current state of vaccine development.

    Science.gov (United States)

    Hong, Joo Eun; Hong, Kee-Jong; Choi, Woo Young; Lee, Won-Ja; Choi, Yeon Hwa; Jeong, Chung-Hyeon; Cho, Kwang-Il

    2014-12-01

    Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with Ebola Hemorrhagic Fever (EHF) was continuously increasing even though the any effective therapeutics or vaccines has not been developed yet. The Ebola virus in Guinea showed 98% homology with Zaire Ebola Virus. Study of the pathogenesis of Ebola virus infection and assess of the various candidates of vaccine have been tried for a long time, especially in United States and some European countries. Even though the attenuated live vaccine and DNA vaccine containing Ebola viral genes were tested and showed efficacy in chimpanzees, those candidates still need clinical tests requiring much longer time than the preclinical development to be approved for the practical treatment. It can be expected to eradicate Ebola virus by a safe and efficient vaccine development similar to the case of smallpox virus which was extinguished from the world by the variola vaccine.

  1. Microbial lipolytic fusion enzymes: current state and future perspectives.

    Science.gov (United States)

    Gudiukaite, Renata; Gricajeva, Alisa

    2017-11-27

    Genetic fusion of coding ORFs or connection of proteins in a post translational process are rather novel techniques to build products called fusion proteins that possess combined characteristics of their parental biomolecules. This attractive strategy used to create new enzymes not only diversifies their functionality by improving thermostability, thermo- and catalytic activity, substrate specificity, regio- or enantio-selectivity but also facilitates their purification and increases their yield. Many examples of microbial synthetic fusion biocatalysts are associated with fused enzymes that are involved in biomass degradation. However, one of the leading production segments is occupied by microbial lipolytic enzymes (lipases and esterases). As powerful biocatalysts these enzymes found their application in detergent, food, oil and fat, pulp and paper, leather, textile, cosmetics, biodiesel production industries. Moreover, lipolytic enzymes market is predicted to maintain leadership up to the year of 2024 and exceed millions of dollars. Recently, creation of lipolytic fusion biocatalysts for industrial applications gained more attention since it is not only a way of achievement of enzymes with improved properties but also a way to reduce industrial energy costs and ensure other economic benefits. This paper provides a comprehensive review on current state of microbial lipolytic fusion enzymes and their future potential.

  2. Biodiesel production--current state of the art and challenges.

    Science.gov (United States)

    Vasudevan, Palligarnai T; Briggs, Michael

    2008-05-01

    Biodiesel is a clean-burning fuel produced from grease, vegetable oils, or animal fats. Biodiesel is produced by transesterification of oils with short-chain alcohols or by the esterification of fatty acids. The transesterification reaction consists of transforming triglycerides into fatty acid alkyl esters, in the presence of an alcohol, such as methanol or ethanol, and a catalyst, such as an alkali or acid, with glycerol as a byproduct. Because of diminishing petroleum reserves and the deleterious environmental consequences of exhaust gases from petroleum diesel, biodiesel has attracted attention during the past few years as a renewable and environmentally friendly fuel. Since biodiesel is made entirely from vegetable oil or animal fats, it is renewable and biodegradable. The majority of biodiesel today is produced by alkali-catalyzed transesterification with methanol, which results in a relatively short reaction time. However, the vegetable oil and alcohol must be substantially anhydrous and have a low free fatty acid content, because the presence of water or free fatty acid or both promotes soap formation. In this article, we examine different biodiesel sources (edible and nonedible), virgin oil versus waste oil, algae-based biodiesel that is gaining increasing importance, role of different catalysts including enzyme catalysts, and the current state-of-the-art in biodiesel production.

  3. State of multicultural neuropsychological assessment in children: current research issues.

    Science.gov (United States)

    Byrd, Desiree; Arentoft, Alyssa; Scheiner, Diane; Westerveld, Michael; Baron, Ida Sue

    2008-09-01

    Scientific attention to cultural considerations in child neuropsychological assessment has not developed parallel to the focus these issues have received in adult and elderly neuropsychological assessment. There are limited data on the presence, magnitude, etiology, and implications of culture-related differences in cognitive test performance among children. This preliminary report reviews the available empirical literature on the current state of multicultural neuropsychological assessment in children. The review identified articles by searching PubMed and PsycINFO databases, and the tables of contents of Developmental Neuropsychology and Child Neuropsychology from 2003-2008. Of the 1,834 abstracts reviewed, ten papers met inclusion criteria for the review. Five studies were completed in America; four of these compared performance between ethnic groups while the fifth examined neighborhood level poverty indicators exclusively within African-American children. Of the five international studies, all established local normative data and/or were exploratory investigations of neuropsychological functions in specific cultural groups, including Taiwanese infants, South African youth, and bilingual British children. Taken together, the results yield important clinical and research data that begin to inform many of the complex and fascinating mechanisms by which ethnic identity and culture impact cognitive development and the neuropsychological assessment of children. A critique of the existing literature and directions for future research are provided.

  4. Electronic money in russia: current state and problems of development

    Directory of Open Access Journals (Sweden)

    T. G. Bondarenko

    2016-01-01

    Full Text Available Article is devoted to urgent problems of non-cash methods of calculation development by using electronic money – as one of the modern economically developed state strategic tasks. On modern economic science strong influence appears informatization process. The control expansion tendency, influence and distribution of commerce due to informatization of society led to emergence of the new phenomenon – information economy. Information economy brought new economic events which owing to their novelty are insufficiently studied to life. It is possible to carry electronic money to such phenomena of modern network economy Relevance and, in our opinion, timeliness of this scientific work, consisting in novelty of this non-cash payment method, its prospects and innovation within non-cash methods of calculations. Authors set as the purpose – studying of problems and the prospects of development of electronic money in the Russian Federation. In article theoretical bases of electronic money functioning are described. Determinations and classifications dismissed non-cash a method, and also the principles of electronic money functioning are considered, the questions of their historical development are raised.Authors analyzed statistical data on development of electronic services and channels of their using. Features, benefits and shortcomings of the current state of the market of electronic money are studied. The emphasis on that fact that in modern conditions considerable number of economic actors perform the activities, both in the real environment of economy, and within the virtual environment that promotes expansion of methods of their customer interaction by means of technical devices of personal computers, mobile phones is placed. In article common problems and tendencies of payments with using an electronic money are designated, the research on assessment of the current state and the prospects of electronic money

  5. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    OpenAIRE

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald?J.; Rasmussen, Helge?H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no know...

  6. Angular dependence of the exchange bias for the bistable state

    Energy Technology Data Exchange (ETDEWEB)

    Bai, Yuhao [College of Physics and Electronic Information, Shanxi Normal University, Linfen 041004 (China); Research College of materials science, Shanxi Normal University, Linfen 041004 (China); Xu, Xiaohong, E-mail: xuxh@dns.sxnu.edu.cn [Research College of materials science, Shanxi Normal University, Linfen 041004 (China); Key Laboratory of Magnetic Molecules and Magnetic Information Materials, Ministry of Education, Shanxi Normal University, Linfen 041004 (China)

    2017-06-15

    The angular dependence of the exchange bias (ADEB) has been investigated in detail when the exchange-coupled ferromagnetic (FM)/antiferromagnetic (AFM) bilayer is in the bistable state. Complete and incomplete jump phenomena were found at the intrinsic easy and hard axes, when they pass through two special positions making the angular deviation of 58.2826° and 121.7174° from the easy axis of the uniaxial anisotropy, respectively. The combination of these different types of the jump phenomena at the intrinsic easy and hard axes yields five distinct types of the ADEB. The physical condition for each type of ADEB is established. Additionally, the extreme value problem of the exchange bias field and coercivity are also discussed, which is an important technological issue in the design of the magnetoresistive and spintronic devices. These results enable us to make a comprehensive understanding of the experimental ADEB curves.

  7. Local bifurcations in differential equations with state-dependent delay

    Science.gov (United States)

    Sieber, Jan

    2017-11-01

    A common task when analysing dynamical systems is the determination of normal forms near local bifurcations of equilibria. As most of these normal forms have been classified and analysed, finding which particular class of normal form one encounters in a numerical bifurcation study guides follow-up computations. This paper builds on normal form algorithms for equilibria of delay differential equations with constant delay that were developed and implemented in DDE-Biftool recently. We show how one can extend these methods to delay-differential equations with state-dependent delay (sd-DDEs). Since higher degrees of regularity of local center manifolds are still open for sd-DDEs, we give an independent (still only partial) argument which phenomena from the truncated normal must persist in the full sd-DDE. In particular, we show that all invariant manifolds with a sufficient degree of normal hyperbolicity predicted by the normal form exist also in the full sd-DDE.

  8. State-to-state three-atom time-dependent reactive scattering in hyperspherical coordinates.

    Science.gov (United States)

    Crawford, Jeff; Parker, Gregory A

    2013-02-07

    We present a time-dependent, hyperspherical wave packet method for calculating three-atom state-to-state S-matrix elements. The wave packet is propagated in time using adiabatically adjusting, principal axes hyperspherical coordinates that treat all arrangement channels equivalently, allowing the simultaneous analysis of the products in all three arrangement channels. We take advantage of the symmetry of the potential energy surface and decompose the initial wave packet into its component irreducible representations, propagating each component separately. Each irreducible representation component of the wave packet is analyzed by projecting it onto the hyperspherical basis at a fixed, asymptotic hyperradius, and irreducible representation dependent S-matrix elements are obtained by matching the hyperspherical projections to symmetry-adapted Jacobi coordinate boundary conditions. We obtain arrangement channel-dependent S-matrix elements as linear combinations of the irreducible representation dependent elements. State-to-state H + H(2) and F + H(2) results for zero total angular momentum are presented.

  9. Radio pulsar glitches as a state-dependent Poisson process

    Science.gov (United States)

    Fulgenzi, W.; Melatos, A.; Hughes, B. D.

    2017-10-01

    Gross-Pitaevskii simulations of vortex avalanches in a neutron star superfluid are limited computationally to ≲102 vortices and ≲102 avalanches, making it hard to study the long-term statistics of radio pulsar glitches in realistically sized systems. Here, an idealized, mean-field model of the observed Gross-Pitaevskii dynamics is presented, in which vortex unpinning is approximated as a state-dependent, compound Poisson process in a single random variable, the spatially averaged crust-superfluid lag. Both the lag-dependent Poisson rate and the conditional distribution of avalanche-driven lag decrements are inputs into the model, which is solved numerically (via Monte Carlo simulations) and analytically (via a master equation). The output statistics are controlled by two dimensionless free parameters: α, the glitch rate at a reference lag, multiplied by the critical lag for unpinning, divided by the spin-down rate; and β, the minimum fraction of the lag that can be restored by a glitch. The system evolves naturally to a self-regulated stationary state, whose properties are determined by α/αc(β), where αc(β) ≈ β-1/2 is a transition value. In the regime α ≳ αc(β), one recovers qualitatively the power-law size and exponential waiting-time distributions observed in many radio pulsars and Gross-Pitaevskii simulations. For α ≪ αc(β), the size and waiting-time distributions are both power-law-like, and a correlation emerges between size and waiting time until the next glitch, contrary to what is observed in most pulsars. Comparisons with astrophysical data are restricted by the small sample sizes available at present, with ≤35 events observed per pulsar.

  10. Temperature dependence of the current in Schottky-barrier source-gated transistors

    Science.gov (United States)

    Sporea, R. A.; Overy, M.; Shannon, J. M.; Silva, S. R. P.

    2015-05-01

    The temperature dependence of the drain current is an important parameter in thin-film transistors. In this paper, we propose that in source-gated transistors (SGTs), this temperature dependence can be controlled and tuned by varying the length of the source electrode. SGTs comprise a reverse biased potential barrier at the source which controls the current. As a result, a large activation energy for the drain current may be present which, although useful in specific temperature sensing applications, is in general deleterious in many circuit functions. With support from numerical simulations with Silvaco Atlas, we describe how increasing the length of the source electrode can be used to reduce the activation energy of SGT drain current, while maintaining the defining characteristics of SGTs: low saturation voltage, high output impedance in saturation, and tolerance to geometry variations. In this study, we apply the dual current injection modes to obtain drain currents with high and low activation energies and propose mechanisms for their exploitation in future large-area integrated circuit designs.

  11. Help-seeking by substance dependants presenting to healthcare professionals in the Free State Province

    Directory of Open Access Journals (Sweden)

    P M van Zyl

    2012-08-01

    Full Text Available Introduction. Current data regarding treatment needs in South Africa for substance dependence are based on admissions to specialised treatment centres. The data therefore do not include patients presenting to independent healthcare workers and state hospitals. Aim. The aim of this study was to investigate help-seeking behaviour for substance dependence disorders from the perspective of healthcare professionals at various levels of the referral chain in Free State Province. Design. A descriptive study was performed. Setting. Treatment environments in Free State Province accessible to substance-dependent persons. Participants. General practitioners, private psychiatrists, prescribing healthcare professionals at state hospitals and treatment centres, and non-prescribing therapists responsible for management of substance-dependent persons. Measurements. A questionnaire was used to determine the level of help-seeking experienced by the participants regarding various classes of psycho-active substances. Findings. The presentation of alcohol, cannabis, opioid, benzodiazepine, ecstasy, cocaine and inhalant dependency at general practitioners, private psychiatrists, treatment centres and non-prescribing therapists was compared. Different patterns of help-seeking for substance dependence from the various professional groups were detected. Regarding alcohol dependence, 40.3% of private general medical practitioners reported being confronted with alcohol dependence at least once per month, compared with 100% of treatment centre representatives and private psychiatrists, 70.6% of state hospitals and 53.8% of non-prescribers. State hospitals reported the highest frequency for contact with cases of cannabis dependence, compared with the other professional groups, while psychiatrists reported the highest contact with cases involving benzodiazepine, cocaine and ecstasy. Therapists reported a higher level of contact with inhalant dependence, while this group

  12. NOAA Historical Tidal Current Data for the Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Knowledge of the timing and strength of tidal currents is extremely important for safe navigation in coastal waters. Tidal currents are almost always the strongest...

  13. State dependence, personality, and plants: light-foraging decisions in Mimosa pudica (L.).

    Science.gov (United States)

    Simon, Franz W; Hodson, Christina N; Roitberg, Bernard D

    2016-09-01

    Plants make foraging decisions that are dependent on ecological conditions, such as resource availability and distribution. Despite the field of plant behavioral ecology gaining momentum, ecologists still know little about what factors impact plant behavior, especially light-foraging behavior. We made use of the behavioral reaction norm approach to investigate light foraging in a plant species that exhibits rapid movement: Mimosa pudica. We explored how herbivore avoidance behavior in M. pudica (which closes its leaflets temporarily when disturbed) is affected by an individual's energy state and the quality of the current environment and also repeatedly tested the behavior of individuals from two seed sources to determine whether individuals exhibit a "personality" (i.e., behavioral syndrome). We found that when individuals are in a low-energy state, they adopt a riskier light-foraging strategy, opening leaflets faster, and not closing leaflets as often in response to a disturbance. However, when plants are in a high-energy state, they exhibit a plastic light-foraging strategy dependent on environment quality. Although we found no evidence that individuals exhibit behavioral syndromes, we found that individuals from different seed sources consistently behave differently from each other. Our results suggest that plants are capable of making state-dependent decisions and that plant decision making is complex, depending on the interplay between internal and external factors.

  14. Mental health care in Germany: current state and trends.

    Science.gov (United States)

    Salize, Hans Joachim; Rössler, Wulf; Becker, Thomas

    2007-03-01

    Germany turned towards community-based mental health care in the mid seventies, during a general climate of social and political reform. The continuing deinstitutionalisation process and the implementation of community mental health services was considerably affected by the reunification of East and West Germany in 1990, which required dramatic changes in the structure and quality of the mental health care system of the former German Democratic Republic (GDR). Overall, German mental health care is organised as a subsidiary system, where planning and regulating mental health care is the responsibility of the 16 federal states. So German mental health care provision is spread among many sectors and characterised by considerable regional differences. A key characteristic is the particularly wide gap between inpatient and outpatient services, which are funded separately and staffed by different teams. In 2003 the total number of psychiatric beds was a mere two thirds of the overall bed capacity in 1991, the first year as a re-unified Germany, when psychiatric beds in East and West Germany totalled 80,275. From 1970 onwards the number of psychiatric beds was cut by roughly half. So the momentum of the reform has been strong enough to assimilate the completely different mental health care system of the former German Democratic Republic and, in the course of a decade, to re-structure mental health services for an additional 17-18 million new inhabitants. In an ongoing struggle to adapt to changing administrative set-ups, legal frameworks, and financial constraints, psychiatry in Germany in currently facing specific problems and is seriously challenged to defend to considerable achievements of the past. A major obstacle to achieving this aim lies in the fragmented system of mental health care provision and mental health care funding.

  15. The European Drought Observatory (EDO): Current State and Future Directions

    Science.gov (United States)

    Vogt, Jürgen; Sepulcre, Guadalupe; Magni, Diego; Valentini, Luana; Singleton, Andrew; Micale, Fabio; Barbosa, Paulo

    2013-04-01

    Europe has repeatedly been affected by droughts, resulting in considerable ecological and economic damage and climate change studies indicate a trend towards increasing climate variability most likely resulting in more frequent drought occurrences also in Europe. Against this background, the European Commission's Joint Research Centre (JRC) is developing methods and tools for assessing, monitoring and forecasting droughts in Europe and develops a European Drought Observatory (EDO) to complement and integrate national activities with a European view. At the core of the European Drought Observatory (EDO) is a portal, including a map server, a metadata catalogue, a media-monitor and analysis tools. The map server presents Europe-wide up-to-date information on the occurrence and severity of droughts, which is complemented by more detailed information provided by regional, national and local observatories through OGC compliant web mapping and web coverage services. In addition, time series of historical maps as well as graphs of the temporal evolution of drought indices for individual grid cells and administrative regions in Europe can be retrieved and analysed. Current work is focusing on validating the available products, developing combined indicators, improving the functionalities, extending the linkage to additional national and regional drought information systems and testing options for medium-range probabilistic drought forecasting across Europe. Longer-term goals include the development of long-range drought forecasting products, the analysis of drought hazard and risk, the monitoring of drought impact and the integration of EDO in a global drought information system. The talk will provide an overview on the development and state of EDO, the different products, and the ways to include a wide range of stakeholders (i.e. European, national river basin, and local authorities) in the development of the system as well as an outlook on the future developments.

  16. Current state of orthodontic patients under bisphosphonate therapy.

    Science.gov (United States)

    Krieger, Elena; Jacobs, Collin; Walter, Christian; Wehrbein, Heinrich

    2013-04-04

    Bisphosphonates are a common medication for the prevention and therapy of osteoporosis, but are also applied for tumor diseases. They affect bone metabolism, and therefore also orthodontic treatments, but how it does has yet not been definitively clarified. Therefore, the aim of this research was to evaluate and demonstrate the reported effects and the current state of scientific research regarding orthodontic treatment and bisphosphonate medication exclusively in humans. A systematic research of the literature for selected keywords in the Medline database (Pubmed) as well as a manual search was conducted. The following search terms were used: 'Bisphosphonate' in combination with: orthodontic, orthodontic treatment, tooth movement. To date, only nine reported patients (case reports/series) and one original article (retrospective cohort study) regarding orthodontic treatment under bisphosphonate medication in humans have been published. Decelerated tooth movement with increased side effects (especially in high-risk patients) and longer treatment duration was reported in some articles. Patients with initial spacing or extraction cases had a higher risk of incomplete space closure and poor root parallelism. Orthodontic tooth movement under bisphosphonate medication is possible, especially in low-risk patients (low dose and short period of intake). But the treatment is still not predictable, especially in high-risk patients. Therefore, the altered bone metabolism and higher extent of side effects should be considered in treatment planning, especially in extraction cases or high-risk patients. Regardless, longer treatment duration, decelerated tooth movement, and more side effects, e.g., incomplete space closure and poor root parallelism, should be expected, especially in extraction cases or space closure.

  17. Current state of orthodontic patients under Bisphosphonate therapy

    Science.gov (United States)

    2013-01-01

    Background Bisphosphonates are a common medication for the prevention and therapy of osteoporosis, but are also applied for tumor diseases. They affect bone metabolism, and therefore also orthodontic treatments, but how it does has yet not been definitively clarified. Therefore, the aim of this research was to evaluate and demonstrate the reported effects and the current state of scientific research regarding orthodontic treatment and bisphosphonate medication exclusively in humans. Material and methods A systematic research of the literature for selected keywords in the Medline database (Pubmed) as well as a manual search was conducted. The following search terms were used: ‘Bisphosphonate’ in combination with: orthodontic, orthodontic treatment, tooth movement. Findings To date, only nine reported patients (case reports/series) and one original article (retrospective cohort study) regarding orthodontic treatment under bisphosphonate medication in humans have been published. Decelerated tooth movement with increased side effects (especially in high-risk patients) and longer treatment duration was reported in some articles. Patients with initial spacing or extraction cases had a higher risk of incomplete space closure and poor root parallelism. Conclusions Orthodontic tooth movement under bisphosphonate medication is possible, especially in low-risk patients (low dose and short period of intake). But the treatment is still not predictable, especially in high-risk patients. Therefore, the altered bone metabolism and higher extent of side effects should be considered in treatment planning, especially in extraction cases or high-risk patients. Regardless, longer treatment duration, decelerated tooth movement, and more side effects, e.g., incomplete space closure and poor root parallelism, should be expected, especially in extraction cases or space closure. PMID:23556517

  18. Pediatric digital radiography education for radiologic technologists: current state

    International Nuclear Information System (INIS)

    Morrison, Gregory; Culbertson, John; Carbonneau, Kira; John, Susan D.; Goske, Marilyn J.; Smith, Susan N.; Charkot, Ellen; Herrmann, Tracy

    2011-01-01

    Digital radiography (DR) is one of several new products that have changed our work processes from hard copy to digital formats. The transition from analog screen-film radiography to DR requires thorough user education because of differences in image production, processing, storage and evaluation between the forms of radiography. Without adequate education, radiologic technologists could unknowingly expose children to higher radiation doses than necessary for adequate radiograph quality. To evaluate knowledge about image quality and dose management in pediatric DR among radiologic technologists in the U.S. This communication describes a survey of 493 radiologic technologists who are members of the American Society of Radiologic Technologists (ASRT) and who evaluated the current state of radiological technologist education in image quality and dose management in pediatric DR. The survey included 23 survey questions regarding image acquisition issues, quality assurance, radiation exposure and education in DR of infants and children. Radiologic technologists express many needs in areas of training and education in pediatric DR. Suggested improvements include better tools for immediate feedback about image quality and exposure, more information about appropriate technique settings for pediatric patients, more user-friendly vendor manuals and educational materials, more reliable measures of radiation exposure to patients, and more regular and frequent follow-up by equipment vendors. There is a clear and widespread need for comprehensive and practical education in digital image technology for radiologic technologists, especially those engaged in pediatric radiography. The creation of better educational materials and training programs, and the continuation of educational opportunities will require a broad commitment from equipment manufacturers and vendors, educational institutions, pediatric radiology specialty organizations, and individual imaging specialists. (orig.)

  19. Current Cigarette Smoking Among Adults - United States, 2016.

    Science.gov (United States)

    Jamal, Ahmed; Phillips, Elyse; Gentzke, Andrea S; Homa, David M; Babb, Stephen D; King, Brian A; Neff, Linda J

    2018-01-19

    The U.S. Surgeon General has concluded that the burden of death and disease from tobacco use in the United States is overwhelmingly caused by cigarettes and other combusted tobacco products (1). Cigarettes are the most commonly used tobacco product among U.S. adults, and about 480,000 U.S. deaths per year are caused by cigarette smoking and secondhand smoke exposure (1). To assess progress toward the Healthy People 2020 target of reducing the proportion of U.S. adults aged ≥18 years who smoke cigarettes to ≤12.0% (objective TU-1.1),* CDC analyzed data from the 2016 National Health Interview Survey (NHIS). In 2016, the prevalence of current cigarette smoking among adults was 15.5%, which was a significant decline from 2005 (20.9%); however, no significant change has occurred since 2015 (15.1%). In 2016, the prevalence of cigarette smoking was higher among adults who were male, aged 25-64 years, American Indian/Alaska Native or multiracial, had a General Education Development (GED) certificate, lived below the federal poverty level, lived in the Midwest or South, were uninsured or insured through Medicaid, had a disability/limitation, were lesbian, gay, or bisexual (LGB), or had serious psychological distress. During 2005-2016, the percentage of ever smokers who quit smoking increased from 50.8% to 59.0%. Proven population-based interventions are critical to reducing the health and economic burden of smoking-related diseases among U.S. adults, particularly among subpopulations with the highest smoking prevalences (1,2).

  20. The Origins and Current State of Plastic Surgery Residency in the United States.

    Science.gov (United States)

    Mackay, Donald Roy; Johnson, Shane

    2015-11-01

    The history of plastic surgery residency training in the United States dates back to the establishment of plastic surgery as a specialty. The pivotal role played by the American Board of Plastic Surgery is outlined. The history of the early regulatory bodies leading to the formation of the Accreditation Council for Graduate Medical Education and the Residency Review Committees and the establishment of the American Council of Academic Plastic Surgeons gives context to our current training models.

  1. Welfare state: Milestones of development and the current status

    Directory of Open Access Journals (Sweden)

    D A Zakharyan

    2016-12-01

    Full Text Available The article describes the evolution of ideas about the social state as a fair state based on the concept of the social contract. L. von Stein argues that the purpose of the welfare state was not changing the class structure of society and the elimination of the contradictions between the classes, but rather balancing and minimizing conflicts with the help of property transformations allowing a person to change one’s class affiliation. The main condition for the existence of the welfare state is its policies compliance with the interests of citizens, which provides political stability and social security. The central idea of the welfare constitutional state is that the rights of citizens are guaranteed by the state. The functions of the state and its social responsibilities were transforming over time mainly due to the erosion of state, private and corporate responsibility for providing social services. In most cases, the social programs are developed by the state, but they can also be provided by commercial organizations in the “consumer society”, in which all things and services have a material value and benefit. The welfare state is based on the principle of social justice in the distribution of wealth among the population, thus, every democratic state seeks to become a welfare state, which implies a high level of confidence in the government.

  2. Guiding of slow Ne7+ ions through nanocapillaries in insulating polyethylene terephthalate: Incident current dependence

    International Nuclear Information System (INIS)

    Stolterfoht, N.; Hellhammer, R.; Bundesmann, J.; Fink, D.; Kanai, Y.; Kambara, T.; Ikeda, T.; Hoshino, M.; Yamazaki, Y.

    2007-01-01

    The transmission of highly charged ions through nanocapillaries in insulating polyethylene terephthalate (PET) polymers was investigated. In experiments at laboratories in RIKEN (Japan) and HMI (Germany) different detection methods were applied to study the ion current dependence in a wide range covering two orders of magnitude. At HMI an electrostatic ion spectrometer was used and at RIKEN a two-dimensional position sensitive detector was implemented. New PET samples with parallel capillaries and low density were manufactured. For tilted capillaries, the ions are guided along the capillary axis, since the majority of ions are deflected in a charge patch created in the capillary entrance. The results provide insights into the mechanisms of capillary guiding. The fraction of transmitted ions was found to be nearly independent on the incident ion current indicating a sudden increase in the discharge current depleting the entrance charge patch. The experimental results were well-reproduced by model calculations based on a nonlinear (exponential) expression for the discharge current

  3. Exploration is dependent on reproductive state, not social state, in a cooperatively breeding bird

    Science.gov (United States)

    Dugdale, Hannah L.; Richardson, David S.; Komdeur, Jan; Burke, Terry

    2016-01-01

    Personality is an intriguing phenomenon in populations because it constrains behavioral flexibility. One theory suggests that personality could be generated and maintained if dependent on asset protection. It is predicted that trade-offs with fitness expectations and survival probability encourage consistent behavioral differences among individuals (personality). Although not mutually exclusive, the social niche specialization hypothesis suggests that a group of individuals that repeatedly interact will develop personality to avoid costly social conflict. The point at which behavioral consistency originates in the social niche hypothesis is still unclear, with predictions for development after a change in social status. In the facultative cooperatively breeding Seychelles warbler (Acrocephalus sechellensis), residing on Cousin Island, breeding vacancies are limited and this forces individuals into different social roles. We used this system to test whether reproductive and social state predicted among-individual differences in exploration. We had 2 predictions. First, that an individual’s start in life can predict personality, whereby young individuals with a good start to life (associated with early age reproduction and earlier onset survival senescence) are fast explorers, suggesting reproductive state-dependence. Second, that an individual’s social status can predict personality, whereby dominant individuals will be fast explorers, suggesting that the behavior is social state-dependent. Neither of the behaviors was associated with social state and social state did not affect behavioral consistency. However, novel object exploration was associated with a proxy of reproductive state. Our results provide further support for state being a mechanism for generating individual differences in behavior. PMID:28028379

  4. Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Georgios K. Papageorgiou

    2016-04-01

    Full Text Available Mesolimbic dopamine encodes the benefits of a course of action. However, the value of an appetitive reward depends strongly on an animal’s current state. To investigate the relationship between dopamine, value, and physiological state, we monitored sub-second dopamine release in the nucleus accumbens core while rats made choices between food and sucrose solution following selective satiation on one of these reinforcers. Dopamine signals reflected preference for the reinforcers in the new state, decreasing to the devalued reward and, after satiation on food, increasing for the valued sucrose solution. These changes were rapid and selective, with dopamine release returning to pre-satiation patterns when the animals were re-tested in a standard food-restricted state. Such rapid and selective adaptation of dopamine-associated value signals could provide an important signal to promote efficient foraging for a varied diet.

  5. KCNE5 Induces Time- and Voltage-Dependent Modulation of the KCNQ1 Current

    OpenAIRE

    Angelo, Kamilla; Jespersen, Thomas; Grunnet, Morten; Nielsen, Morten Schak; Klaerke, Dan A.; Olesen, Søren-Peter

    2002-01-01

    The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 current. Interaction of the KCNQ1 channel with KCNE5 shifted the voltage activation curve of KCNQ1 by more than 140 mV in the positive direction. The activation threshold of the KCNQ1+KCNE5 complex was +40 mV and the midpoint of activation was +116 mV. The KCNQ1+KCNE5 current activated slowly and deactivated rapidly as com...

  6. Paramagnetic effect in a current-carrying cylindrical superconductor and its application in the study of the intermediate state

    International Nuclear Information System (INIS)

    Frolov, V.A.; Kan, Y.S.

    1981-01-01

    The effect of a weak longitudinal magnetic field on the characteristics of the paramagnetic effect (PME) in a current-carrying cylinder has been experimentally investigated for those fields for which the magnitude of the PME oscillations as the current is varied. A model for the PME whose magnitude oscillates as the current varied is proposed on the basis of the London model for the intermediate state of a current-carrying cylinder. The dependence of the period of the London structure on the current strength is computed from the experimental data within the framework of this model

  7. Force-free state in a superconducting single crystal and angle-dependent vortex helical instability

    Science.gov (United States)

    del Valle, J.; Gomez, A.; Gonzalez, E. M.; Manas-Valero, S.; Coronado, E.; Vicent, J. L.

    2017-06-01

    Superconducting 2 H -NbS e2 single crystals show intrinsic low pinning values. Therefore, they are ideal materials with which to explore fundamental properties of vortices. (V , I ) characteristics are the experimental data we have used to investigate the dissipation mechanisms in a rectangular-shaped 2 H -NbS e2 single crystal. Particularly, we have studied dissipation behavior with magnetic fields applied in the plane of the crystal and parallel to the injected currents, i.e., in the force-free state where the vortex helical instability governs the vortex dynamics. In this regime, the data follow the elliptic critical state model and the voltage dissipation shows an exponential dependence, V ∝eα (I -IC ∥ ) , IC ∥ being the critical current in the force-free configuration and α a linear temperature-dependent parameter. Moreover, this exponential dependence can be observed for in-plane applied magnetic fields up to 40° off the current direction, which implies that the vortex helical instability plays a role in dissipation even out of the force-free configuration.

  8. Goal-dependent current compensation and drift in surf scoter flocks.

    Science.gov (United States)

    Lukeman, Ryan; Christie, Alexis; Ydenberg, Ronald C

    2016-01-01

    Animals moving through air or water toward a goal frequently must contend with fluid currents, which can drift the actual path of the animal away from the direction of heading. Whether, and to what degree, animals compensate for currents depends on the species and environmental context, but plays an important role in the movement ecology of the species. In this paper, flocks of surf scoters (Melanitta perspicillata), an aquatic diving duck, were individually tracked during collective foraging in the presence of sideward water currents to assess the individual compensatory response while moving from open water toward the foraging location versus return to open water. During short-range movement toward the foraging location, surf scoters moved more slowly, and compensated for currents by orienting diagonally into the current to maintain a perpendicular track to the goal. In contrast, during return to open water, surf scoters moved faster, and maintained a perpendicular orientation away from the foraging location, and allowed the sideward current to drift their track diagonally. Surf scoters show a behavioural flexibility in response to currents, alternately using compensation and drift as the movement goal and consequent cost of accuracy change.

  9. Operating tokamaks with steady-state toroidal current

    International Nuclear Information System (INIS)

    Fisch, N.J.

    1981-04-01

    Continuous operation of a tokamak requires, among other things, a means of continuously providing the toroidal current. Various methods have been proposed to provide this current including methods which utilize radio-frequency waves in any of several frequency regimes. Here we elaborate on the prospects of incorporating these current-drive techniques in tokamak reactors, concentrating on the theoretical minimization of the power requirements

  10. Large current modulation and spin-dependent tunneling of vertical graphene/MoS2 heterostructures.

    Science.gov (United States)

    Myoung, Nojoon; Seo, Kyungchul; Lee, Seung Joo; Ihm, G

    2013-08-27

    Vertical graphene heterostructures have been introduced as an alternative architecture for electronic devices by using quantum tunneling. Here, we present that the current on/off ratio of vertical graphene field-effect transistors is enhanced by using an armchair graphene nanoribbon as an electrode. Moreover, we report spin-dependent tunneling current of the graphene/MoS2 heterostructures. When an atomically thin MoS2 layer sandwiched between graphene electrodes becomes magnetic, Dirac fermions with different spins feel different heights of the tunnel barrier, leading to spin-dependent tunneling. Our finding will develop the present graphene heterostructures for electronic devices by improving the device performance and by adding the possibility of spintronics based on graphene.

  11. [Current state of blood transfusion in Yugoslavia and its perspectives].

    Science.gov (United States)

    Bosković, S

    1975-01-01

    The current situation of the transfusion service in this country has been characterised by small-scale operational level, the lack of regional system and basic components of a single service. There is a great variety in the medical and expert point of view starting from the lack of elementary hygienic and technical conditions, down to developed institutions of the European level. This activity has been characterised for the last ten years or so by an effort to win blood-givers at all cost, to enhance production of intravenous solutions which in some factories have obtained factory production volume, to determine basic blood groups and a very modest diagnostics for haemolitic diseases of newly born children. A large number of doctors--transfusiologists have obtained specialists' titles, but without any prospects to change the present status of their work: blood conservation, efforts to win blood-givers and determine blood groups. The differentiation between transfusiologists and clinic-engaged personnel has been increasing, thus making the transfusiologists to be far from the problems of modern haematology and clinical therapy. Observing the situation and status of transfusiology in the developed countries of Western Europe, it is possible to state that the transfusiology is developing in the direction of cooperation and team-work with doctors engaged in clinics. Therefore, cooperation with doctors engaged in clinics should be cultivated and organise team work. The intermediary role of doctors-transfusiologist in the cycle of health improvement should be avoided by all means. 90% of packed blood in this country is consumed in the form of full blood or dry plasma and only 10% in the form of desired derivatives, instead of the contrary case, since the precisely set therapy using new haemostatic medicaments is an economical imperative. The electronic data processing of blood-givers enables doctors-transfusiologists to deal with these problems since this is much cheaper

  12. Current state of continuous ambulatory peritoneal dialysis in Egypt

    Directory of Open Access Journals (Sweden)

    Khaled Mohamed Amin Elzorkany

    2017-01-01

    Full Text Available Patients with end-stage renal disease (ESRD continue to increase in number worldwide, especially in developing countries. Although continuous ambulatory peritoneal dialysis (CAPD has comparable survival advantages as hemodialysis (HD, it is greatly underutilized in many regions worldwide. The prevalence of use of CAPD in Egypt is 0.29/million population in 2017. The aim of this study is to describe the current state and practice of CAPD in Egypt and included 22 adult patients who were treated by CAPD. All the study patients were switched to CAPD after treatment with HD failed due to vascular access problems. Patients were mainly female (68.2 % with the mean age of 49.77 ± 11.41 years. The average duration on CAPD was 1.76 ± 1.30 years. Hypertension was the main cause of end-stage renal disease (ESRD constituting 36.4%, followed by diabetes (27.3 %, and toxic nephropathy (4.5%. Of importance is that about 31.8% of patients had ESRD of unknown etiology. The mean weekly Kt/V urea of patients on PD was 1.92 ± 0.18. The mean hemoglobin, serum calcium, phosphorus, parathormone, and albumin levels were 10.27 ± 1.98 g/dL, 8.36 ± 1.19 mg/dL, 5.70 ± 1.35 mg/dL, 541.18 ± 230.12 pg/mL, and 2.98 ± 0.73 g/dL, respectively. There was no significant difference between diabetic and nondiabetic CAPD patients regarding demographic and laboratory data. Our data indicate that there is continuing underutilization of CAPD in Egypt which may be related to nonavailability of CAPD fluid, patient factors (education and motivation, gradual decline of the efficiency of health-care professionals, and lack of a national program to start PD as the first modality for renal replacement therapy. It is advised to start an organized program to make CAPD widespread and encourage local production of PD fluids to reduce the cost of CAPD.

  13. Current state and future prospects for psychosomatic medicine in Japan.

    Science.gov (United States)

    Murakami, Masato; Nakai, Yoshihide

    2017-01-01

    In this article, we describe the history and current state of psychosomatic medicine (PSM) in Japan and propose measures that could be considered based on our view of the future prospects of PSM in Japan. The Japanese Society of PSM (JSPM) was established in 1959, and the first Department of Psychosomatic Internal Medicine in Japan was established at Kyushu University In 1963. PSM in Japan has shown a prominent, unique development, with 3,300 members (as of March 2016), comprised of 71.6% of medical doctors including psychosomatic internal medicine (PIM) specialists, general internists, psychiatrists, pediatricians, obstetricians and gynecologists, dentists, dermatologists, and others. Most of the non-physician members include psychology and nursing staff specialists. The Japanese Society of Psychosomatic Internal Medicine (JSPIM), founded in 1996, is another major society with more than 1,200 physicians that is mainly composed of internists. The first joint congress of the five major PSM societies from each field was held in 2009. They included the Japanese Society of Psychosomatic Medicine, Psychosomatic Obstetrics and Gynecology, Psychosomatic Pediatric Medicine, Psychosomatic Dental Medicine, and Psychosomatic Internal Medicine. Several subdivided societies in related medical fields have also been established for cardiovascular, digestive, dermatological, and oriental medicine and for eating disorders, pain, fibromyalgia, stress science, behavioral medicine, and psycho-oncology. JSPM and JSPIM participate in international activities including publishing BioPsychoSocial Medicine (BPSM) and the establishment of a sister society relationship with the Germany College of PSM. PSM in Japan has adopted a variety of professional psychotherapies, including transactional analysis, autogenic therapy, and cognitive behavioral therapy. Mutual interrelationship has been promoted by the Japanese Union of Associations for Psycho-medical Therapy (UPM). Although PSM in Japan is

  14. The California spotted owl: current state of knowledge

    Science.gov (United States)

    R.J. Gutiérrez; Patricia N. Manley; Peter A. Stine

    2017-01-01

    This conservation assessment represents a comprehensive review by scientists of the current scientific knowledge about the ecology, habitat use, population dynamics, and current threats to the viability of the California spotted owl (Strix occidentalis). It is based primarily on peer-reviewed published information with an emphasis on new scientific...

  15. Comparison of current density profiles based on particle orbit-driven current in steady-state plasma on QUEST

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Md Mahbub, E-mail: m.alam@triam.kyushu-u.ac.jp [IGSES, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580 (Japan); Nakamura, Kazuo [RIAM, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580 (Japan); Xia, Fan [CFS, SWIP, P.O. Box 432, 610041 Chengdu (China); Mitarai, Osamu [Tokai University, Kumamoto 862-8652 (Japan); Hasegawa, Makoto; Tokunaga, Kazutoshi; Araki, Kuniaki; Zushi, Hideki; Hanada, Kazuaki; Fujisawa, Akihide; Idei, Hiroshi; Nagashima, Yoshihiko; Kawasaki, Shoji; Nakashima, Hisatoshi; Higashijima, Aki; Nagata, Takahiro [RIAM, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580 (Japan)

    2016-11-01

    Highlights: • Electron cyclotron resonance heating (ECRH) of QUEST. • Particle guiding center orbit calculation. • Orbit-driven current density profile. • Hollow current density. • Equilibrium condition for steady-state operation of QUEST. - Abstract: In the present RF-driven divertor plasma of QUEST, it has been observed that orbit-driven current flows in the open magnetic surfaces outside of the closed magnetic surfaces. To observe this phenomenon and the characteristics of the orbit-driven current, current density profiles have been calculated on two different equilibrium conditions. We calculated current density profiles from particle guiding center orbits both for the fundamental and the second harmonic resonances for the 8.2 GHz electron cyclotron current drive. From this calculation, hollow current density profiles have been obtained with significant characteristics on both conditions. Only positive current distribution has been observed in the open magnetic surfaces outside of the closed magnetic surfaces.

  16. Spatially-Resolved Beam Current and Charge-State Distributions for the NEXT Ion Engine

    Science.gov (United States)

    Pollard, James E.; Diamant, Kevin D.; Crofton, Mark W.; Patterson, Michael J.; Soulas, George C.

    2010-01-01

    Plume characterization tests with the 36-cm NEXT ion engine are being performed at The Aerospace Corporation using engineering-model and prototype-model thrusters. We have examined the beam current density and xenon charge-state distribution as functions of position on the accel grid. To measure the current density ratio j++/j+, a collimated Eprobe was rotated through the plume with the probe oriented normal to the accel electrode surface at a distance of 82 cm. The beam current density jb versus radial position was measured with a miniature planar probe at 3 cm from the accel. Combining the j++/j+ and jb data yielded the ratio of total Xe+2 current to total Xe+1 current (J++/J+) at forty operating points in the standard throttle table. The production of Xe+2 and Xe+3 was measured as a function of propellant utilization to support performance and lifetime predictions for an extended throttle table. The angular dependence of jb was measured at intermediate and far-field distances to assist with plume modeling and to evaluate the thrust loss due to beam divergence. Thrust correction factors were derived from the total doubles-to-singles current ratio and from the far-field divergence data

  17. Effect of avermectins on Ca2+-dependent Cl- currents in plasmalemma of Chara corallina cells.

    Science.gov (United States)

    Drinyaev, V A; Mosin, V A; Kruglyak, E B; Sterlina, T S; Kataev, A A; Berestovsky, G N; Kokoz, Y M

    2001-07-01

    A natural complex of avermectins, aversectin C, and a component of this complex, avermectin A1, were shown to change the conductivity of Ca2+-dependent Cl- channels of plasmalemma of Chara corallina cells by acting from the outer side of the cellular membrane. Low concentrations of aversectin C and avermectin A1 increased the Cl- current: K1/2 = 35 ng/ml for the whole complex and K1/2 = 21 pg/ml for A1. Relatively high concentrations of the compounds suppressed the Cl- current: K1/2 = 2.2 microg/ml for aversectin C and K1/2 = 4.2 ng/ml for A1. The Hill coefficient for the interaction of avermectin A1 with the corresponding targets was identical for stimulation and suppression of the Cl- current: 2.8 and 2.5, respectively. Bicuculline, a nonspecific inhibitor of the GABAa receptors, did not influence stimulation of Cl- currents caused by low concentrations of avermectins, but at the same time blocked suppression of the Cl- currents by high concentrations of avermectins. Avermectins A2, B1, B2, abamectin and 22,23-dihydroavermectin B1 (ivermectin) did not affect the Cl- currents of Chara corallina cells.

  18. [Effect of avermectns on Ca(2+)-dependent chloride currents in plasmalemma of Chara corallina cells].

    Science.gov (United States)

    Driniaev, V A; Mosin, V A; Krugliak, E B; Sterlina, T S; Viktorov, A V; Kataev, A A; Berestovskiĭ, G N; Kataev, T S; Kokoz, Iu M

    2001-01-01

    A natural complex of avermectins, aversectin C, and a component of this complex, avermectin A1, were shown to change the conductivity of Ca(2+)-dependent chloride channels of plasmalemma of Chara corallina cells by acting only from the outer side of the cellular membrane. Low concentrations of aversectin C and avermectin A1 increased the chloride current: K1/2 = 3.5 x 10(-5) mg/ml for the whole complex and K1/2 = 2.1 x 10(-3) mg/ml for A1. Relatively high concentrations of the compounds suppressed the chloride current: K1/2 = 2.2 x 10(-3) mg/ml for aversectin C and K1/2 = 4.2 x 10(-6) mg/ml for A1. The Hill coefficients for the interaction of avermectin A1 with the corresponding targets for stimulation and suppression of the chloride current were 2.8 and 2.5 respectively. Bicuculine, a non-specific inhibitor of the GABA alpha-receptors, did not influence stimulation of chloride currents caused by action of low concentrations of avermectins, but at the same time blocked suppression of the chloride currents associated with the action of high doses of avermectins. Avermectins A2, B1 (abamectin), B2 and 22,23-dihydroavermectin B1 (vermectin) in the concentration range studied, did not affect the chloride currents of Chara corallina cells.

  19. Current-dependent inactivation induced by sodium depletion in normal and batrachotoxin-treated frog node of Ranvier

    Science.gov (United States)

    1984-01-01

    In batrachotoxin (BTX)-treated frog node of Ranvier, in spite of a marked reduction in Na inactivation, the Na current still presents a time- and voltage-dependent inactivation that could induce a 50-60% decrease in the current. The inactivation was found to be modified by changing the amplitude of a conditioning pulse, adding tetrodotoxin in the external solution, or replacing NaCl with KCl in the external solution. Conditioning pulses were able to alter the reversal potential of the BTX-modified Na current (Vrev). Vrev was shifted toward negative values for inward conditioning currents and was shifted toward positive values for outward conditioning currents. The change in Vrev was proportional to the conditioning current amplitude. Large inward currents induced 15-25 mV shifts of Vrev. During a 10-20-ms depolarizing pulse, the inactivation and change in Vrev were proportional to the time integral of the current. For longer depolarizations, Vrev reached a steady state level proportional to the current amplitude. The conductance, as calculated from the current and the actual Vrev, showed an inactivation proportional to exp(Vrev F/RT). These observations suggest that the BTX-modified Na current induces a decrease in local Na concentrations, which results in an alteration of the driving force and the conductance. During a pulse that induced a large inward current, the Na space concentration [( Na]s) changed from 114 to 50-60 mM. In normal fibers, the reversal potential of Na current was also shifted toward negative values by a prepulse that induced a large inward current. The change in Vrev reached 5-15 mV, which corresponded to a decrease in [Na]s of 20-50 mM. This change in Vrev slightly altered the time course of Na current. On the basis of a three- compartment model (axoplasm-perinodal space-bulk solution), a Na permeability of the barrier between the space and the bulk solution (PNa,s) and a mean thickness of the space (theta) were calculated. The mean value of

  20. Review of the current state of UAV regulations

    NARCIS (Netherlands)

    Stöcker, Elvira Claudia; Bennett, Rohan; Nex, Francesco; Gerke, Markus; Zevenbergen, Jaap

    2017-01-01

    UAVs-unmanned aerial vehicles-facilitate data acquisition at temporal and spatial scales that still remain unachievable for traditional remote sensing platforms. However, current legal frameworks that regulate UAVs present significant barriers to research and development. To highlight the

  1. Biotechnological uses of Azotobacter vinelandii : Current state, limits ...

    African Journals Online (AJOL)

    African Journal of Biotechnology. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 33 (2010) >. Log in or Register to get access to full text downloads.

  2. Chiropractic and public health: current state and future vision.

    Science.gov (United States)

    Johnson, Claire; Baird, Rand; Dougherty, Paul E; Globe, Gary; Green, Bart N; Haneline, Michael; Hawk, Cheryl; Injeyan, H Stephen; Killinger, Lisa; Kopansky-Giles, Deborah; Lisi, Anthony J; Mior, Silvano A; Smith, Monica

    2008-01-01

    This article provides an overview of primary chiropractic issues as they relate to public health. This collaborative summary documents the chiropractic profession's current involvement in public health, reflects on past barriers that may have prevented full participation within the public health movement, and summarizes the relationship of current chiropractic and public health topics. Topics discussed include how the chiropractic profession participates in preventive health services, health promotion, immunization, geriatrics, health care in a military environment, and interdisciplinary care.

  3. Nonequilibrium current-carrying steady states in the anisotropic X Y spin chain

    Science.gov (United States)

    Lancaster, Jarrett L.

    2016-05-01

    Out-of-equilibrium behavior is explored in the one-dimensional anisotropic X Y model. Initially preparing the system in the isotropic X X model with a linearly varying magnetic field to create a domain-wall magnetization profile, dynamics is generated by rapidly changing the exchange interaction anisotropy and external magnetic field. Relaxation to a nonequilibrium steady state is studied analytically at the critical transverse Ising point, where correlation functions may be computed in closed form. For arbitrary values of anisotropy and external field, an effective generalized Gibbs' ensemble is shown to accurately describe observables in the long-time limit. Additionally, we find spatial oscillations in the exponentially decaying, transverse spin-spin correlation functions with wavelength set by the magnetization jump across the initial domain wall. This wavelength depends only weakly on anisotropy and magnetic field in contrast to the current, which is highly dependent on these parameters.

  4. Fault current limiter with solid-state circuit breakers

    Science.gov (United States)

    Bălan, H.; Neamț, L.; Buzdugan, M. I.; Varodi, T.; Pop, E.

    2016-08-01

    Switching of power circuit breakers is an important technical issue, especially at short circuit, since the fault current cause thermal and dynamic stresses, and the power quality worsens. Recently, the development of distributed renewable electricity induces the short circuit protection problematic because the distributed production of electric energy cause the transport networks to lose their radial character and disturbs the protective relays coordination. The modern technologies for power switching uses static fault current limiters, which offers a viable solution to remove the problems caused by large fault currents in the system. An appropriate design of the current limiting device reduces the thermal and dynamic stress and limits the fault current to a low value. The static switches are based on high power semiconductor devices that offer advantages compared to mechanical switches. Using a fault current limiter that minimizes the effect of distributed generation of electricity in a radial network on the co-ordination of protective relays is a solution to this problem in terms of switching speed and lifespan of power switches.

  5. Current State of the U.S. Ethanol Industry

    Energy Technology Data Exchange (ETDEWEB)

    Urbanchuk, John [Cardno ENTRIX, New Castle, DE (United States)

    2010-11-30

    The objective of this study is to provide a comprehensive overview of the state of the U.S. ethanol industry and to outline the major forces that will affect the development of the industry over the next decade.

  6. Contactless estimation of critical current density and its temperature dependence using magnetic measurements

    Czech Academy of Sciences Publication Activity Database

    Youssef, A.; Baničová, L.; Švindrych, Zdeněk; Janů, Zdeněk

    2010-01-01

    Roč. 118, č. 5 (2010), s. 1036-1037 ISSN 0587-4246. [Czech and Slovak Conference on Magnetism /14./. Košice, 06.07.2010-09.07.2010] R&D Projects: GA MŠk(CZ) ME10069 Institutional research plan: CEZ:AV0Z10100520 Keywords : superconductivity * critical state * Bean model * critical current density Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.467, year: 2010

  7. Conserved Noether Currents, Utiyama's Theory of Invariant Variation, and Velocity Dependence in Local Gauge Invariance

    Science.gov (United States)

    Darvas, Gyrgy

    2009-01-01

    The paper discusses the mathematical consequences of the application of derived variables in gauge fields. Physics is aware of several phenomena, which depend first of all on velocities (like e.g., the force caused by charges moving in a magnetic field, or the Lorentz transformation). Applying the property of the second Noether theorem, that allowed generalised variables, this paper extends the article by Al-Kuwari and Taha (1991) with a new conclusion. They concluded that there are no extra conserved currents associated with local gauge invariance. We show, that in a more general case, there are further conserved Noether currents. In its method the paper reconstructs the clue introduced by Utiyama (1956, 1959) and followed by Al-Kuwari and Taha (1991) in the presence of a gauge field that depends on the co-ordinates of the velocity space. In this course we apply certain (but not full) analogies with Mills (1989). We show, that handling the space-time coordinates as implicit variables in the gauge field, reproduces the same results that have been derived in the configuration space (i.e., we do not lose information), while the proposed new treatment gives additional information extending those. The result is an extra conserved Noether current.

  8. Temperature and current dependent electroluminescence measurements on colour-coded multiple quantum well light emitting diodes

    International Nuclear Information System (INIS)

    Bergbauer, Werner; Laubsch, Ansgar; Peter, Matthias; Mayer, Tobias; Bader, Stefan; Oberschmid, Raimund; Hahn, Berthold; Benstetter, Guenther

    2008-01-01

    As the efficiency and the luminous flux have been increased enormously in the last few years, today Light Emitting Diodes (LEDs) are even pushed to applications like general lighting and Home Cinema Projection. Still, InGaN/GaN heterostructure based LEDs suffer from loss-mechanisms like non-radiative defect and Auger recombination, carrier leakage and piezo-field induced carrier separation. To optimize the high current efficiency we evaluated the benefit of Multiple Quantum Well (MQW) compared to Single Quantum Well (SQW) LEDs. Temperature dependent electroluminescence of colour-coded structures with different Indium content in certain Quantum Wells was measured. The experiments demonstrated a strong temperature and current dependence of the MQW operation. The comparison between different LED structures showed effectively the increased LED performance of those structures which operate with a well adjusted MQW active area. Due to the enhanced carrier distribution in the high current range, these LEDs show a higher light output and additionally a reduced wavelength shift

  9. Lucifer Yellow slows voltage-gated Na+ current inactivation in a light-dependent manner in mice

    Science.gov (United States)

    Higure, Yoko; Katayama, Yoshimi; Takeuchi, Keita; Ohtubo, Yoshitaka; Yoshii, Kiyonori

    2003-01-01

    Lucifer Yellow CH (LY), a membrane-impermeant fluorescent dye, has been used in electrophysiological studies to visualize cell morphology, with little concern about its pharmacological effects. We investigated its effects on TTX-sensitive voltage-gated Na+ channels in mouse taste bud cells and hippocampal neurons under voltage-clamp conditions. LY applied inside cells irreversibly slowed the inactivation of Na+ currents upon exposure to light of usual intensities. The inactivation time constant of Na+ currents elicited by a depolarization to −15 mV was increased by fourfold after a 5 min exposure to halogen light of 3200 lx at source (3200 lx light), and sevenfold after a 1-min exposure to 12 000 lx light. A fraction of the Na+ current became non-inactivating following the exposure. The non-inactivating current was ≈ 20 % of the peak total Na+ current after a 5 min exposure to 3200 lx light, and ≈ 30 % after a 1 min exposure to 12 000 lx light. Light-exposed LY shifted slightly the current-voltage relationship of the peak Na+ current and of the steady-state inactivation curve, in the depolarizing direction. A similar light-dependent decrease in kinetics occurred in whole-cell Na+ currents of cultured mouse hippocampal neurones. Single-channel recordings showed that exposure to 6500 lx light for 3 min increased the mean open time of Na+ channels from 1.4 ms to 2.4 ms without changing the elementary conductance. The pre-incubation of taste bud cells with 1 mM dithiothreitol, a scavenger of radical species, blocked these LY effects. These results suggest that light-exposed LY yields radical species that modify Na+ channels. PMID:12879866

  10. Association between current smoking and cognitive impairment depends on age: A cross-sectional study in Xi'an, China.

    Science.gov (United States)

    Liu, Jie; Shang, Suhang; Li, Pei; Deng, Meiying; Chen, Chen; Jiang, Yu; Dang, Liangjun; Qu, Qiumin

    2017-09-08

    Cigarette smoking is a modifiable risk factor for cognitive impairment, while the relationship between current smoking and cognitive impairment is not fully understood. The objectives were to identify a possible association between current smoking and cognitive impairment depending on age in the Chinese rural population. Data for the study consisted of 1,782 participants (40 years and older) who lived in a rural village in the vicinity of Xi'an, China. Data about smoking history and cognitive function were collected. Cognitive function was scored by the Mini-Mental State Examination. The effect of age on the relationship between current smoking and cognitive impairment was analyzed with interaction and stratified analysis by logistic regression models. Interaction analysis showed that current smoking is positively related with cognitive impairment (odds ratio [OR]=9.067; 95% confidence interval [95% CI] 1.305-62.979; P=.026). However, the interaction term, age by current smoking, is negatively related with cognitive impairment (OR=0.969; 95%CI 0.939-0.999; P=.045). Stratified logistic regression showed that in the 40-65 years of age sublayer, OR of current smoking is 1.966 (P=.044), whereas in the>65 years of age sublayer, the OR is 0.470 (P=.130). This means that the association between current smoking and cognitive impairment with age might be positive (OR>1) in lower age sublayers, but no significant difference in higher age sublayers. In conclusion, current smoking might be positively associated with cognitive impairment in the middle-aged but the relationship declines with increasing age. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  11. Current state of the art of HNF based composite propellants

    NARCIS (Netherlands)

    Ciucci, A.; Frota, O.; Welland, W.H.M.; Heijden, A.E.D.M. van der; Leeming, B.; Bellerby, J.M.; Brotzu, A.

    2004-01-01

    The main activities currently performed for the development of HNF-based propellants are presented. The objectives and approach adopted are described. The results obtained on the HNF decomposition mechanism and on the re- and co-crystallisation of HNF with potential propellant ingredients are

  12. State of the Art of Current Practices for Transit Transfers.

    Science.gov (United States)

    1981-07-01

    The major objectives of the study are to: (1) describe and summarize the transfer policies currently in use on U.S. transit properties; (2) identify reasons why properties use or do not use particular transfer policies; (3) determine the consequences...

  13. Procoagulant State in Current and Former Anabolic Androgenic Steroid Abusers

    DEFF Research Database (Denmark)

    Chang, Simon; Rasmussen, Jon J; Frandsen, Mikkel N

    2018-01-01

    BACKGROUND:  Anabolic androgenic steroid (AAS) abusers are considered at increased risk of cardiovascular morbidity and mortality. We hypothesized that current and former AAS abuse would induce a procoagulant shift in the haemostatic balance. METHODS:  Men 18 to 50 years of age were included...

  14. The Lifetime Prevalence of Anabolic-Androgenic Steroid Use and Dependence in Americans: Current Best Estimates

    Science.gov (United States)

    Pope, Harrison G.; Kanayama, Gen; Athey, Alison; Ryan, Erin; Hudson, James I.; Baggish, Aaron

    2013-01-01

    Background and Objectives Although various surveys have tracked the prevalence of anabolic-androgenic steroid (AAS) use in American teenagers and young adults, no recent surveys have assessed the lifetime prevalence of AAS use in Americans overall. We therefore analyzed serial youth-survey data to derive estimates of the lifetime prevalence of AAS use in the current American general population. Methods We first determined the distribution of age of onset of AAS use, based on pooled data from nine studies. Using this distribution, we then developed equations to project the eventual lifetime prevalence of AAS use among young survey respondents, once they aged and completed the period of risk for initiating AAS. We similarly calculated the denominator of lifetimes of risk for AAS use in the total American population. We next applied these equations to four independent national youth datasets to derive current American general-population estimates for lifetime AAS use. Finally, using data from 10 pooled studies, we estimated the lifetime prevalence of AAS dependence among AAS users. Results Age-of-onset studies consistently showed that AAS use begins later than most drugs, with only 22% of users (95% confidence interval: 19%–25%) starting before age 20. Applying the age-of-onset findings to national youth datasets, we estimated that among Americans currently age 13 to 50 years, 2.9–4.0 million have used AAS. Within this group, roughly 1 million may have experienced AAS dependence. Conclusions and Scientific Significance Although subject to various limitations, our estimation techniques suggest a surprisinigly high prevalence of AAS use and dependence among Americans. PMID:24112239

  15. Parents as Partners in Schooling: The Current State of Affairs.

    Science.gov (United States)

    Kelley-Laine, Kathleen

    1998-01-01

    Presents an overview of policies and practices related to the parent-school relationship in nine countries including Canada, Denmark, France, Germany, Ireland, Japan, Spain, the United Kingdom, and the United States. Considers reasons for involving parents in schools, discusses two types of parental participation in education, and offers…

  16. English Learners with Learning Disabilities: What Is the Current State?

    Science.gov (United States)

    Rodríguez, Ashley; Rodríguez, Diane

    2017-01-01

    As the demographics across the United States continues to change, specifically with increases in school age English Learners who speak a home language other than English, it is imperative that schools meet the diverse needs of these children. This article summarizes studies about English Learners with learning disabilities. It reports on the…

  17. Aggression in wild house mice : Current state of affairs

    NARCIS (Netherlands)

    Sluyter, F; vanOortmerssen, GA; deRuiter, AJH; Koolhaas, JM

    This paper reviews our present state of knowledge of genetic variation in (offensive) aggression in wild house mice. The basic tools in this research were lines bidirectionally selected for attack latency (fast attacking SAL and slow attacking LAL males), descended from a feral population. Using

  18. Alternatives to current fumigation practices in western states raspberry

    Science.gov (United States)

    Red raspberry production systems in the western United States are heavily reliant on preplant soil fumigation to ensure the successful establishment and productivity of a planting. However, due to issues related to the regulation, availability, and economics of soil fumigation alternatives are need ...

  19. DEPENDENT STANDARD OF HIGH EDUCATION AND THE BRAZILIAN UNIVERSITY CURRENT EXPANSION

    Directory of Open Access Journals (Sweden)

    José Renato Bez de Gregório

    2014-06-01

    Full Text Available This article is based on the theoretical contributions of Florestan Fernandes seeking to analyze the structural and cyclical features of Brazilian higher education, in order to understand to what extent these features constitute the pattern-dependent learning, the historic brand dependent capitalist insertion of Brazil in the global economy and cultural heteronomy associated with it. We assume that such theoretical foundation helps us understand some aspects of the redesign of higher education underway in Brazil conducted by governments Lula da Silva and Dilma Rousseff, particularly the Program of Support to the Restructuring and Expansion of Federal Universities (REUNI. Thus, presenting some data expansion in the two largest public universities in the state of Rio de Janeiro in order to demonstrate the extent to which this process is indicating the precariousness / intensification of teaching and a deep reconfiguration of Brazilian public university.

  20. Coherent states of general time-dependent harmonic oscillator

    Indian Academy of Sciences (India)

    The wave function can then be found easily, by making use of these ladder operators. Glauber proposed standard coherent states for a harmonic oscillator which is the prototype for most of the coherent states [3,4]. The coherent states form a very convenient representation for problems of quantum mechanics and can be ...

  1. Time-dependent current-density functional theory for generalized open quantum systems.

    Science.gov (United States)

    Yuen-Zhou, Joel; Rodríguez-Rosario, César; Aspuru-Guzik, Alán

    2009-06-14

    In this article, we prove the one-to-one correspondence between vector potentials and particle and current densities in the context of master equations with arbitrary memory kernels, therefore extending time-dependent current-density functional theory (TD-CDFT) to the domain of generalized many-body open quantum systems (OQS). We also analyse the issue of A-representability for the Kohn-Sham (KS) scheme proposed by D'Agosta and Di Ventra for Markovian OQS [Phys. Rev. Lett. 2007, 98, 226403] and discuss its domain of validity. We suggest ways to expand their scheme, but also propose a novel KS scheme where the auxiliary system is both closed and non-interacting. This scheme is tested numerically with a model system, and several considerations for the future development of functionals are indicated. Our results formalize the possibility of practising TD-CDFT in OQS, hence expanding the applicability of the theory to non-Hamiltonian evolutions.

  2. Spectroscopy of Technological Defects in Si Solar Cells by Analysis of Temperature Dependent Generation Currents

    Directory of Open Access Journals (Sweden)

    Jevgenij PAVLOV

    2014-09-01

    Full Text Available The efficiency of solar cells considerably depends on the technological defects introduced by the formation of junctions, passivation layers and electrodes. Identification of these defects present in the high conductivity base layer of modern solar cells by usage of the standard techniques, such as capacitance deep level spectroscopy, is restricted by extremely small size of samples with inherent enhanced leakage current on sample boundaries. Therefore, it is important to develop the alternative methods for the defect spectroscopy in the high conductivity junction structures, to directly control a relative low concentration of the technological defects. In this work, the spectroscopy of deep traps has been performed by combining the temperature scans of the thermal generation currents extracted from barrier capacitance charging transients and capacitance deep level transient spectroscopy techniques. The dominant carrier traps ascribed to the Cu and Ni impurities were revealed. DOI: http://dx.doi.org/10.5755/j01.ms.20.3.5194

  3. Structural parameter dependence of directed current generation in GaAs nanowire-based electron Brownian ratchet devices

    OpenAIRE

    Abe, Yushi; Kuroda, Ryota; Ying, Xiang; Sato, Masaki; Tanaka, Takayuki; Kasai, Seiya

    2015-01-01

    We investigated the structural parameter dependence of the directed current in GaAs-nanowire-based Brownian ratchet devices. The directed current was generated by flashing a ratchet potential array repeatedly using multiple asymmetric gates with a periodic signal. The amount of current in the fabricated device increased as the nanowire width W decreased, which contradicted the theoretical model. The current also depended on the number of the gates N, when N was smaller than 6. We discussed th...

  4. Structural parameter dependence of directed current generation in GaAs nanowire-based electron Brownian ratchet devices

    Science.gov (United States)

    Abe, Yushi; Kuroda, Ryota; Ying, Xiang; Sato, Masaki; Tanaka, Takayuki; Kasai, Seiya

    2015-06-01

    We investigated the structural parameter dependence of the directed current in GaAs-nanowire-based Brownian ratchet devices. The directed current was generated by flashing a ratchet potential array repeatedly using multiple asymmetric gates with a periodic signal. The amount of current in the fabricated device increased as the nanowire width W decreased, which contradicted the theoretical model. The current also depended on the number of the gates N, when N was smaller than 6. We discussed the obtained results in terms of the structural parameter dependence of carrier transfer efficiency and the effect of electron reservoirs on current generation in flashing ratchet operation.

  5. The Current State of Physics in Cuba: A Personal Perspective

    Science.gov (United States)

    Alonso, Marcelo

    After 40 years of absence I returned twice to Cuba, in January and December of 2000, to participate as a guest lecturer in two international scientific meetings. The first dealt with physics education, and the second with current issues related to quantum mechanics. In addition to a few participants from Europe, the US and Latin America, the two meetings were well attended by Cuban physicists.

  6. Public Administration: Modernizing The Current Model Of State Management

    OpenAIRE

    Evgenii V. Ohotskii

    2014-01-01

    Applying the method of retrospective analysis the article deals with the process of forming the scientific fundamentals and the search by the international community of effective and adequate to the current stage of social development public administration system. The author attempts to analyze, in a number of cases in terms of models, features of public administration systems at different stages of historical development, drawing attention to reasons why the Soviet model of public administra...

  7. KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current

    DEFF Research Database (Denmark)

    Angelo, Kamilla; Jespersen, Thomas; Grunnet, Morten

    2002-01-01

    The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 current. Interaction of the KCNQ1 channel with KCNE5 shifted the voltage activation curve of KCNQ1 by more than 140 m......V in the positive direction. The activation threshold of the KCNQ1+KCNE5 complex was +40 mV and the midpoint of activation was +116 mV. The KCNQ1+KCNE5 current activated slowly and deactivated rapidly as compared to the KCNQ1+KCNE1 at 22 degrees C; however, at physiological temperature, the activation time constant...... of the KCNQ1+KCNE5 current decreased fivefold, thus exceeding the activation rate of the KCNQ1+KCNE1 current. The KCNE5 subunit is specific for the KCNQ1 channel, as none of other members of the KCNQ-family or the human ether a-go-go related channel (hERG1) was affected by KCNE5. Four residues...

  8. Optimised effective potential for ground states, excited states, and time-dependent phenomena

    International Nuclear Information System (INIS)

    Gross, E.K.U.

    1996-01-01

    (1) The optimized effective potential method is a variant of the traditional Kohn-Sham scheme. In this variant, the exchange-correlation energy E xc is an explicit functional of single-particle orbitals. The exchange-correlation potential, given as usual by the functional derivative v xc = δE xc /δρ, then satisfies as integral equation involving the single-particle orbitals. This integral equation in solved semi-analytically using a scheme recently proposed by Krieger, Li and Iafrate. If the exact (Fock) exchange-energy functional is employed together with the Colle-Salvetti orbital functional for the correlation energy, the mean absolute deviation of the resulting ground-state energies from the exact nonrelativistic values is CT mH for the first-row atoms, as compared to 4.5 mH in a state-of-the-art CI calculation. The proposed scheme is thus significantly more accurate than the conventional Kohn-Sham method while the numerical effort involved is about the same as for an ordinary Hanree-Fock calculation. (2) A time-dependent generalization of the optimized-potential method is presented and applied to the linear-response regime. Since time-dependent density functional theory leads to a formally exact representation of the frequency-dependent linear density response and since the latter, as a function of frequency, has poles at the excitation energies of the fully interacting system, the formalism is suitable for the calculation of excitation energies. A simple additive correction to the Kohn-Sham single-particle excitation energies will be deduced and first results for atomic and molecular singlet and triplet excitation energies will be presented. (3) Beyond the regime of linear response, the time-dependent optimized-potential method is employed to describe atoms in strong emtosecond laser pulses. Ionization yields and harmonic spectra will be presented and compared with experimental data

  9. The current state of FPGA technology in the nuclear domain

    Energy Technology Data Exchange (ETDEWEB)

    Ranta, J.

    2012-07-01

    Field programmable gate arrays are a form of programmable electronic device used in various applications including automation systems. In recent years, there has been a growing interest in the use of FPGA-based systems also for safety automation of nuclear power plants. The interest is driven by the need for reliable new alternatives to replace, on one hand, the aging technology currently in use and, on the other hand, microprocessor and software-based systems, which are seen as overly complex from the safety evaluation point of view. This report presents an overview of FPGA technology, including hardware aspects, the application development process, risks and advantages of the technology, and introduces some of the current systems. FPGAs contain an interesting combination of features from software-based and fully hardware-based systems. Application development has a great deal in common with software development, but the final product is a hardware component without the operating system and other platform functions on which software would execute. Currently the number of FPGA-based applications used for safety functions of nuclear power plants is rather limited, but it is growing. So far there is little experience or common solid understanding between different parties on how FPGAs should be evaluated and handled in the licensing process. (orig.)

  10. Current State of the Art Historic Building Information Modelling

    Science.gov (United States)

    Dore, C.; Murphy, M.

    2017-08-01

    In an extensive review of existing literature a number of observations were made in relation to the current approaches for recording and modelling existing buildings and environments: Data collection and pre-processing techniques are becoming increasingly automated to allow for near real-time data capture and fast processing of this data for later modelling applications. Current BIM software is almost completely focused on new buildings and has very limited tools and pre-defined libraries for modelling existing and historic buildings. The development of reusable parametric library objects for existing and historic buildings supports modelling with high levels of detail while decreasing the modelling time. Mapping these parametric objects to survey data, however, is still a time-consuming task that requires further research. Promising developments have been made towards automatic object recognition and feature extraction from point clouds for as-built BIM. However, results are currently limited to simple and planar features. Further work is required for automatic accurate and reliable reconstruction of complex geometries from point cloud data. Procedural modelling can provide an automated solution for generating 3D geometries but lacks the detail and accuracy required for most as-built applications in AEC and heritage fields.

  11. Thermal state of the general time-dependent harmonic oscillator

    Indian Academy of Sciences (India)

    Harmonic oscillator that has time-dependent mass or frequency may be a good example of time-dependent Hamiltonian systems. Although a large number of dynamical systems have been investigated using approximation and perturbation method in the literature [2,3], we confine our concern to the exact quantum solution ...

  12. Current environmental situation in the new Federal States. Pt. 1

    International Nuclear Information System (INIS)

    Haury, H.J.; Koller, U.; Assmann, G.

    1992-01-01

    'Information on Environment' organised the first part of a seminar for jounalists on the present environmental situation in the now federal states in Berlin on the 3rd and 4th of December. More than 50 participants from radios, TV, daily and special press attended this ninth event of 'Information on Environment' in Berlin. Leading scientists from research institutes of the former GDR, the Federal Environmental Agency and the GSF-research centre for environment and heath gave papers on the predominant environmental problems in the new federal states. This first part deals with water pollution, waste water treatment, drinking water supply, environmental problems of lignite mining, radiation pollution in the Erzgebirge; forest damage research and special armament wastes and waste problems in general. (orig.) [de

  13. Humble beginnings: Current trends, state perspectives, and hallmarks of humility

    OpenAIRE

    Chancellor, J; Lyubomirsky, S

    2013-01-01

    After decades of neglect, research in humility is finally turning a corner. Within the past few years, investigators have articulated two promising strategies to overcome methodological concerns - namely, using personality judgments and designing humility "stress tests" to elicit humility-relevant behavior. We also highlight an alternative perspective of humility that has not yet gained much attention: the investigation of humility as a state, which helps to understand what humility actually ...

  14. Multi-temperature state-dependent equivalent circuit discharge model for lithium-sulfur batteries

    Science.gov (United States)

    Propp, Karsten; Marinescu, Monica; Auger, Daniel J.; O'Neill, Laura; Fotouhi, Abbas; Somasundaram, Karthik; Offer, Gregory J.; Minton, Geraint; Longo, Stefano; Wild, Mark; Knap, Vaclav

    2016-10-01

    Lithium-sulfur (Li-S) batteries are described extensively in the literature, but existing computational models aimed at scientific understanding are too complex for use in applications such as battery management. Computationally simple models are vital for exploitation. This paper proposes a non-linear state-of-charge dependent Li-S equivalent circuit network (ECN) model for a Li-S cell under discharge. Li-S batteries are fundamentally different to Li-ion batteries, and require chemistry-specific models. A new Li-S model is obtained using a 'behavioural' interpretation of the ECN model; as Li-S exhibits a 'steep' open-circuit voltage (OCV) profile at high states-of-charge, identification methods are designed to take into account OCV changes during current pulses. The prediction-error minimization technique is used. The model is parameterized from laboratory experiments using a mixed-size current pulse profile at four temperatures from 10 °C to 50 °C, giving linearized ECN parameters for a range of states-of-charge, currents and temperatures. These are used to create a nonlinear polynomial-based battery model suitable for use in a battery management system. When the model is used to predict the behaviour of a validation data set representing an automotive NEDC driving cycle, the terminal voltage predictions are judged accurate with a root mean square error of 32 mV.

  15. Azelaic acid in dermatological treatment – current state of knowledge

    Directory of Open Access Journals (Sweden)

    Radomir Reszke

    2016-09-01

    Full Text Available Azelaic acid (AZA is a naturally occurring substance produced by Malassezia furfur which exerts various effects on the skin. Azelaic acid has antibacterial, anti-inflammatory, keratolytic, comedolytic, sebostatic and tyrosinase-inhibiting properties. Topical application of AZA as 20% cream or 15% gel is a well-established therapeutic method in various common dermatoses, mainly acne vulgaris, rosacea and disorders associated with hyperpigmentation. Azelaic acid is used as a component of chemical peels as well. The paper summarizes the most relevant issues concerning AZA application in dermatological treatment based on current knowledge.

  16. Current state of the art of blood cell labeling

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.; Gil, M.C.

    1985-01-01

    An update on some recent developments in the area of blood cell labeling is provided. Specific topics covered include red cell labeling with /sup 99m/Tc, platelet labeling using an antiplatelet monoclonal antibody, and the labeling of leukocytes with /sup 99m/Tc. Mechanistic information, where available, is discussed. A critical evaluation of current techniques, their pitfalls as well as advantages, and the problems that remain to be resolved, is presented. The promise shown by recent results using the antibody approach for cell labeling is emphasized. An assessment of the progress made in these areas is presented. 38 refs., 10 figs., 6 tabs

  17. The Current State of Medical Malpractice in Urology.

    Science.gov (United States)

    Sherer, Benjamin A; Coogan, Christopher L

    2015-07-01

    Medical malpractice can present an unwelcome professional, emotional, and economic burden to the practicing urologist. To date, there is a paucity of data specific to urologic malpractice in the literature. We performed a comprehensive literature search to identify and evaluate recent studies related to urologic malpractice. We also analyzed 6249 closed urologic claims from the largest available specialty-specific data set gathered by Physician Insurers Association of America from 1985 to 2012. The resulting comprehensive review seeks to raise awareness of current trends in the malpractice environment specific to urologic surgery while also helping urologists identify opportunities for risk management and improved patient care. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Current state and prospects of high energy physics

    International Nuclear Information System (INIS)

    Okun', L.B.

    1982-01-01

    Experimental and theoretical research into high energy physics is subordinated to the only goal, ie., discovering the fundamental physical laws of Nature. Currently, the quantum field theory has been formulated of electromagnetic, weak and strong interactions, ie., three of the four basic interactions. Efforts are exerted to develop a unified theory of all interactions including the quantum gravitation theory. The following problems are reviewed: fundamental principles, fundamental particles, electromagnetic interactions, weak interactions, strong interactions, scalars, technicolor and new TeV range physics, grand unification, superunification, astrophysics and cosmology, new stable particles, and new types of far-reaching interactions. (Ha)

  19. The current state of bearing surfaces in total hip replacement.

    Science.gov (United States)

    Rajpura, A; Kendoff, D; Board, T N

    2014-02-01

    We reviewed the literature on the currently available choices of bearing surface in total hip replacement (THR). We present a detailed description of the properties of articulating surfaces review the understanding of the advantages and disadvantages of existing bearing couples. Recent technological developments in the field of polyethylene and ceramics have altered the risk of fracture and the rate of wear, although the use of metal-on-metal bearings has largely fallen out of favour, owing to concerns about reactions to metal debris. As expected, all bearing surface combinations have advantages and disadvantages. A patient-based approach is recommended, balancing the risks of different options against an individual's functional demands.

  20. Observer dependence of quantum states in relativistic quantum field theories

    International Nuclear Information System (INIS)

    Malin, S.

    1982-01-01

    Quantum states can be understood as either (i) describing quantum systems or (ii) representing observers' knowledge about quantum systems. These different meanings are shown to imply different transformation properties in relativistic field theories. The rules for the reduction of quantum states and the transformation properties of quantum states under Lorentz transformations are derived for case (ii). The results obtained are applied to a quantum system recently presented and analyzed by Aharonov and Albert. It is shown that the present results, combined with Aharonov and Albert's, amount to a proof of Bohr's view that quantum states represent observers' knowledge about quantum systems

  1. Imaging of HCC—Current State of the Art

    Directory of Open Access Journals (Sweden)

    Christina Schraml

    2015-11-01

    Full Text Available Early diagnosis of hepatocellular carcinoma (HCC is crucial for optimizing treatment outcome. Ongoing advances are being made in imaging of HCC regarding detection, grading, staging, and also treatment monitoring. This review gives an overview of the current international guidelines for diagnosing HCC and their discrepancies as well as critically summarizes the role of magnetic resonance imaging (MRI and computed tomography (CT techniques for imaging in HCC. The diagnostic performance of MRI with nonspecific and hepatobililiary contrast agents and the role of functional imaging with diffusion-weighted imaging will be discussed. On the other hand, CT as a fast, cheap and easily accessible imaging modality plays a major role in the clinical routine work-up of HCC. Technical advances in CT, such as dual energy CT and volume perfusion CT, are currently being explored for improving detection, characterization and staging of HCC with promising results. Cone beam CT can provide a three-dimensional analysis of the liver with tumor and vessel characterization comparable to cross-sectional imaging so that this technique is gaining an increasing role in the peri-procedural imaging of HCC treated with interventional techniques.

  2. [Video game and internet addiction. The current state of research].

    Science.gov (United States)

    Rehbein, F; Mößle, T; Arnaud, N; Rumpf, H-J

    2013-05-01

    The use of interactive screen media is widespread and for some users leads to pathological symptoms that are phenomenologically similar to signs of addictive disorders. Addictive use of computer games and other Internet applications, such as social media can be distinguished. In the past standard criteria to classify this new disorder were lacking. In DSM-5, nine criteria are proposed for diagnosing Internet gaming disorder. The focus is currently on video games as most studies have been done in this field. Prevalence estimations are difficult to interpret due to the lack of standard diagnostic measures and result in a range of the frequency of Internet addiction between 1 % and 4.2 % in the general German population. Rates are higher in younger individuals. For computer game addiction prevalence rates between 0.9 % and 1.7  % can be found in adolescents. Despite substantial comorbidity among those affected current research points to addictive media use as a stand-alone disorder.

  3. Current state of knowledge about nutritional care of pregnant women

    Directory of Open Access Journals (Sweden)

    Luciana Barretto

    2014-12-01

    Full Text Available Pregnancy involves a significant anabolic activity that leads to increased nutritional needs relative to the preconception period. This paper aims to review the current understanding of the energy needs of macro and micronutrients during pregnancy as well as guidelines to address common gastrointestinal disorders during pregnancy, the issue of pica and anthropometric assessment to ensure an optimum weight gain. With the exception of iron, most of the nutrients needed by the pregnancy can be provided by a complete and balanced diet. Currently the scientific evidence shows that routine supplementation with iron and folic acid during pregnancy is a practice that prevents iron deficiency anemia, neural tube disorders and preterm births. Intermittent iron supplementation can also be an appropriated intervention. If the diet does not guarantee and adequate support, iodine, vitamin B12 and vitamin D supplements should also be necessaries. The anthropometric assessment by the pattern of weight gain should be present at each prenatal care visit to prevent maternal and fetal complications. In situations where the mother’s weight cannot be assessed, arm muscle circumference is possible to make an overall assessment as it correlates with maternal weight gain alternative. Measurements of biceps, triceps and subscapular skinfolds are another alternative that is useful to evaluate the fatty deposits and their location, in a complementary way to gain weight.

  4. Imaging of HCC—Current State of the Art

    Science.gov (United States)

    Schraml, Christina; Kaufmann, Sascha; Rempp, Hansjoerg; Syha, Roland; Ketelsen, Dominik; Notohamiprodjo, Mike; Nikolaou, Konstantin

    2015-01-01

    Early diagnosis of hepatocellular carcinoma (HCC) is crucial for optimizing treatment outcome. Ongoing advances are being made in imaging of HCC regarding detection, grading, staging, and also treatment monitoring. This review gives an overview of the current international guidelines for diagnosing HCC and their discrepancies as well as critically summarizes the role of magnetic resonance imaging (MRI) and computed tomography (CT) techniques for imaging in HCC. The diagnostic performance of MRI with nonspecific and hepatobililiary contrast agents and the role of functional imaging with diffusion-weighted imaging will be discussed. On the other hand, CT as a fast, cheap and easily accessible imaging modality plays a major role in the clinical routine work-up of HCC. Technical advances in CT, such as dual energy CT and volume perfusion CT, are currently being explored for improving detection, characterization and staging of HCC with promising results. Cone beam CT can provide a three-dimensional analysis of the liver with tumor and vessel characterization comparable to cross-sectional imaging so that this technique is gaining an increasing role in the peri-procedural imaging of HCC treated with interventional techniques. PMID:26854169

  5. The kinetics and temperature dependence of the pace-maker current if in sheep Purkinje fibres.

    Science.gov (United States)

    Hart, G

    1983-04-01

    The kinetic properties of the if channel in shortened sheep Purkinje fibres were investigated using a two-micro-electrode voltage-clamp technique in the presence of Ba2+, Mn2+ and tetrodotoxin (TTX). The time course of the hyperpolarization-activated if currents (DiFrancesco, 1981 b) at potentials within the activation range was found to depend on whether the channel was switching 'on' or 'off'. At potentials positive to the half-activation point if decay was faster than if onset; at potentials negative to the half-activation point if onset was faster than if decay. The time courses of if onset and decay become similar only at potentials close to the centre of the activation range. If a single exponential was fitted to the time course of if switching, the time constant (tau y) was found to vary as a function of potential from approximately 50 msec to several seconds. The tau y - voltage relation is an extremely steep bell-shaped distribution. Reducing external Na+ (range 140-17.5 mM) did not alter the voltage dependence of the if time course. Increasing external K+ (range 5-60 mM) shifted the if time constants and activation curve by similar amounts in a depolarizing direction. The temperature dependence of if was investigated over the range 27.5-41 degrees C. Cooling reversibly slowed the time course of if activation with a Q10 of 3.13 (S.D. +/- 0.85, n = 62). A reversible reduction in the slope of the fully-activated current-voltage relation was observed on cooling, the Q10 being 1.35 (S.D. +/- 0.07), and was usually accompanied by a small depolarizing shift of the half-activation point and the reversal potential Ef. It is concluded that the if time course shows a marked potential dependence and does not obey Hodgkin-Huxley kinetics. Its temperature dependence resembles that of if in the sino-atrial node (DiFrancesco & Ojeda, 1980).

  6. Towards time-dependent current-density-functional theory in the non-linear regime.

    Science.gov (United States)

    Escartín, J M; Vincendon, M; Romaniello, P; Dinh, P M; Reinhard, P-G; Suraud, E

    2015-02-28

    Time-Dependent Density-Functional Theory (TDDFT) is a well-established theoretical approach to describe and understand irradiation processes in clusters and molecules. However, within the so-called adiabatic local density approximation (ALDA) to the exchange-correlation (xc) potential, TDDFT can show insufficiencies, particularly in violently dynamical processes. This is because within ALDA the xc potential is instantaneous and is a local functional of the density, which means that this approximation neglects memory effects and long-range effects. A way to go beyond ALDA is to use Time-Dependent Current-Density-Functional Theory (TDCDFT), in which the basic quantity is the current density rather than the density as in TDDFT. This has been shown to offer an adequate account of dissipation in the linear domain when the Vignale-Kohn (VK) functional is used. Here, we go beyond the linear regime and we explore this formulation in the time domain. In this case, the equations become very involved making the computation out of reach; we hence propose an approximation to the VK functional which allows us to calculate the dynamics in real time and at the same time to keep most of the physics described by the VK functional. We apply this formulation to the calculation of the time-dependent dipole moment of Ca, Mg and Na2. Our results show trends similar to what was previously observed in model systems or within linear response. In the non-linear domain, our results show that relaxation times do not decrease with increasing deposited excitation energy, which sets some limitations to the practical use of TDCDFT in such a domain of excitations.

  7. Frequency dependence of CA3 spike phase response arising from h-current properties

    Directory of Open Access Journals (Sweden)

    Melodie eBorel

    2013-12-01

    Full Text Available The phase of firing of hippocampal neurons during theta oscillations encodes spatial information. Moreover, the spike phase response to synaptic inputs in individual cells depends on the expression of the hyperpolarisation-activated mixed cation current (Ih, which differs between CA3 and CA1 pyramidal neurons. Here, we compared the phase response of these two cell types, as well as their intrinsic membrane properties. We found that both CA3 and CA1 pyramidal neurons show a voltage sag in response to negative current steps but that this voltage sag is significantly smaller in CA3 cells. Moreover, CA3 pyramidal neurons have less prominent resonance properties compared to CA1 pyramidal neurons. This is consistent with differential expression of Ih by the two cell types. Despite their distinct intrinsic membrane properties, both CA3 and CA1 pyramidal neurons displayed bidirectional spike phase control by excitatory conductance inputs during theta oscillations. In particular, excitatory inputs delivered at the descending phase of a dynamic clamp-induced membrane potential oscillation delayed the subsequent spike by nearly 50 mrad. The effect was shown to be mediated by Ih and was counteracted by increasing inhibitory conductance driving the membrane potential oscillation. Using our experimental data to feed a computational model, we showed that differences in Ih between CA3 and CA1 pyramidal neurons could predict frequency-dependent differences in phase response properties between these cell types. We confirmed experimentally such frequency-dependent spike phase control in CA3 neurons. Therefore, a decrease in theta frequency, which is observed in intact animals during novelty, might switch the CA3 spike phase response from unidirectional to bidirectional and thereby promote encoding of the new context.

  8. Towards time-dependent current-density-functional theory in the non-linear regime

    Energy Technology Data Exchange (ETDEWEB)

    Escartín, J. M. [Université de Toulouse, UPS, Laboratoire de Physique Théorique, IRSAMC, F-31062 Toulouse Cedex (France); CNRS, UMR5152, F-31062 Toulouse Cedex (France); Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Vincendon, M.; Dinh, P. M.; Suraud, E. [Université de Toulouse, UPS, Laboratoire de Physique Théorique, IRSAMC, F-31062 Toulouse Cedex (France); CNRS, UMR5152, F-31062 Toulouse Cedex (France); Romaniello, P. [Laboratoire de Physique Théorique, CNRS, IRSAMC, Université Toulouse III - Paul Sabatier and European Theoretical Spectroscopy Facility, 118 Route de Narbonne, 31062 Toulouse Cedex (France); Reinhard, P.-G. [Institut für Theoretische Physik, Universität Erlangen, Staudtstraße 7, D-91058 Erlangen (Germany)

    2015-02-28

    Time-Dependent Density-Functional Theory (TDDFT) is a well-established theoretical approach to describe and understand irradiation processes in clusters and molecules. However, within the so-called adiabatic local density approximation (ALDA) to the exchange-correlation (xc) potential, TDDFT can show insufficiencies, particularly in violently dynamical processes. This is because within ALDA the xc potential is instantaneous and is a local functional of the density, which means that this approximation neglects memory effects and long-range effects. A way to go beyond ALDA is to use Time-Dependent Current-Density-Functional Theory (TDCDFT), in which the basic quantity is the current density rather than the density as in TDDFT. This has been shown to offer an adequate account of dissipation in the linear domain when the Vignale-Kohn (VK) functional is used. Here, we go beyond the linear regime and we explore this formulation in the time domain. In this case, the equations become very involved making the computation out of reach; we hence propose an approximation to the VK functional which allows us to calculate the dynamics in real time and at the same time to keep most of the physics described by the VK functional. We apply this formulation to the calculation of the time-dependent dipole moment of Ca, Mg and Na{sub 2}. Our results show trends similar to what was previously observed in model systems or within linear response. In the non-linear domain, our results show that relaxation times do not decrease with increasing deposited excitation energy, which sets some limitations to the practical use of TDCDFT in such a domain of excitations.

  9. Long-lasting alterations in membrane properties, K+ currents and glutamatergic synaptic currents of nucleus accumbens medium spiny neurons in a rat model of alcohol dependence

    Directory of Open Access Journals (Sweden)

    Igor eSpigelman

    2012-06-01

    Full Text Available Chronic alcohol exposure causes marked changes in reinforcement mechanisms and motivational state that are thought to contribute to the development of cravings and relapse during protracted withdrawal. The nucleus accumbens (NAcc is a key structure of the mesolimbic dopaminergic reward system. Although the NAcc plays an important role in mediating alcohol-seeking behaviors, little is known about the molecular mechanisms underlying alcohol-induced neuroadaptive changes in NAcc function. The aim of this study was to investigate the effects of chronic intermittent ethanol (CIE treatment, a rat model of alcohol withdrawal and dependence, on intrinsic electrical membrane properties and glutamatergic synaptic transmission of medium spiny neurons (MSNs in the NAcc core during protracted withdrawal. We show that CIE treatment followed by prolonged withdrawal increased the inward rectification of MSNs observed at hyperpolarized potentials. In addition, MSNs from CIE-treated animals displayed a lower input resistance, faster action potentials (APs and larger fast afterhyperpolarizations (fAHPs than MSNs from vehicle-treated animals, all suggestive of increases in K+-channel conductances. Significant increases in the Cs+-sensitive inwardly-rectifying K+-current accounted for the increased input resistance, while increases in the A-type K+-current accounted for the faster APs and increased fAHPs in MSNs from CIE rats. We also show that the amplitude and the conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR-mediated mEPSCs were enhanced in CIE-treated animals due to an increase in a small fraction of functional postsynaptic GluA2-lacking AMPARs. These long-lasting modifications of excitability and excitatory synaptic receptor function of MSNs in the NAcc core could play a critical role in the neuroadaptive changes underlying alcohol withdrawal and dependence.

  10. Current state of the art of vision based SLAM

    Science.gov (United States)

    Muhammad, Naveed; Fofi, David; Ainouz, Samia

    2009-02-01

    The ability of a robot to localise itself and simultaneously build a map of its environment (Simultaneous Localisation and Mapping or SLAM) is a fundamental characteristic required for autonomous operation of the robot. Vision Sensors are very attractive for application in SLAM because of their rich sensory output and cost effectiveness. Different issues are involved in the problem of vision based SLAM and many different approaches exist in order to solve these issues. This paper gives a classification of state-of-the-art vision based SLAM techniques in terms of (i) imaging systems used for performing SLAM which include single cameras, stereo pairs, multiple camera rigs and catadioptric sensors, (ii) features extracted from the environment in order to perform SLAM which include point features and line/edge features, (iii) initialisation of landmarks which can either be delayed or undelayed, (iv) SLAM techniques used which include Extended Kalman Filtering, Particle Filtering, biologically inspired techniques like RatSLAM, and other techniques like Local Bundle Adjustment, and (v) use of wheel odometry information. The paper also presents the implementation and analysis of stereo pair based EKF SLAM for synthetic data. Results prove the technique to work successfully in the presence of considerable amounts of sensor noise. We believe that state of the art presented in the paper can serve as a basis for future research in the area of vision based SLAM. It will permit further research in the area to be carried out in an efficient and application specific way.

  11. Medicines Regulation in Africa: Current State and Opportunities.

    Science.gov (United States)

    Ndomondo-Sigonda, Margareth; Miot, Jacqueline; Naidoo, Shan; Dodoo, Alexander; Kaale, Eliangiringa

    2017-01-01

    Sound regulatory systems are critical for protecting public health against use of medical products which do not meet international standards of quality, safety and efficacy. This review provides a summary of the current status of National Medicines Regulatory Authorities (NMRAs) in Africa, and various initiatives that have been established to improve their performance. All countries in Africa (except Sahrawi Republic), have NMRAs but their organizational set-up and functionality is variable. Some are located within Ministries of Health and others are semi-autonomous. There is progressive improvement in regulatory capacity, particularly in quality control and post-marketing surveillance, pharmacovigilance and clinical trials oversight. The African Vaccines Regulatory Forum, African Medicines Regulatory Harmonization Initiative, Network of Official Medicines Control Laboratories and WHO Prequalification Scheme have helped countries strengthen their regulatory capacities. The potential establishment of the African Medicines Agency (AMA) in 2018 is an opportunity to improve NMRAs' capacity in Africa.

  12. Current state of the art and future of myectomy.

    Science.gov (United States)

    Yacoub, Magdi H; Afifi, Ahmed; Saad, Hesham; Aguib, Heba; ElGuindy, Ahmed

    2017-07-01

    Surgical relief of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) requires more than septal myectomy. The procedure is currently the gold standard for all symptomatic HCM patients except those with comorbidities. The operation requires an individualized approach to restore the sophisticated functions of the left ventricular outflow tract (LVOT) without injury to the surrounding vital structures. The procedure should be tailored to deal with all the varied components of the obstruction including fibrous trigones, accessory tissues, and papillary muscle fusion. Preoperative multimodality imaging and numerical modeling combined with intraoperative transesophageal echocardiography (TEE) are essential to define existing anomalies as well as assess the adequacy of the repair. The mitral valve can be conserved in virtually all patients. The operation can be conducted with very low mortality and morbidity with predictable good outcomes both in the short and long term. Nevertheless, surgical relief of LVOTO is still grossly underused.

  13. [The current state of the brain-computer interface problem].

    Science.gov (United States)

    Shurkhay, V A; Aleksandrova, E V; Potapov, A A; Goryainov, S A

    2015-01-01

    It was only 40 years ago that the first PC appeared. Over this period, rather short in historical terms, we have witnessed the revolutionary changes in lives of individuals and the entire society. Computer technologies are tightly connected with any field, either directly or indirectly. We can currently claim that computers are manifold superior to a human mind in terms of a number of parameters; however, machines lack the key feature: they are incapable of independent thinking (like a human). However, the key to successful development of humankind is collaboration between the brain and the computer rather than competition. Such collaboration when a computer broadens, supplements, or replaces some brain functions is known as the brain-computer interface. Our review focuses on real-life implementation of this collaboration.

  14. The concept of electronegativity. The current state of the problem

    International Nuclear Information System (INIS)

    Cherkasov, Artem R; Galkin, Vladimir I; Zueva, Ekaterina M; Cherkasov, Rafael A

    1998-01-01

    A systematic account is given of the current ideas about atomic and group electronegativities and the trends in the development of the concept of electronegativity are analysed. Attention is concentrated on the latest approaches to the definition of electronegativity - the concept of 'orbital' electronegativities and the density functional theory. A procedure is proposed for the determination of 'inductive' electronegativities, which permits a correct theoretical calculation of the electronegativity of a substituent from the electronegativities of individual atoms and the steric structure. It is shown that the approach developed has a series of important advantages - for example, it makes it possible to calculate the group electronegativities of isomeric substituents avoiding the principle of the equalisation of electronegativities. A survey of literature data and generalisation of the method proposed by the authors have made it possible to formulate the concept of electronegativity as an unchanging fundamental immanent characteristic of a chemical element. The bibliography includes 222 references.

  15. Current state and trend of radiation regulation system in Japan

    International Nuclear Information System (INIS)

    Yonehara, Hidenori

    2004-01-01

    Japanese regulation system for safety against radiation essentially started from 'Atomic Energy Basic Law' enacted in 1955 and 'Law Concerning Prevention of Radiation Hazards due to Radioisotopes, etc' enacted in 1957, has been regarded as a central rule for radiation protection and safety. Related laws and regulations have been enacted together with their revision. Radiation Council, established in the Science and Technology Agency in 1962 and now belonging to the Ministry of Education, Culture, Sports, Science and Technology, has deliberated basically on International Commission of Radiological Protection (ICRP) statements for legal revision and has set up working groups for current problems. Activities of the groups have concerned ICRP Publication 60 (1990) and later related publications for incorporating the principle into laws as to concepts of dose limits, effective dose, and then of exemption and exclusion. International status of the Japanese regulation, problems and tasks in the regulation are also commented. (N.I.)

  16. Disentangling the roles of frequency- vs. state-dependence in generating individual differences in behavioural plasticity

    NARCIS (Netherlands)

    Mathot, Kimberley J.; van den Hout, Piet J.; Piersma, Theunis; Kempenaers, Bart; Reale, Denis; Dingemanse, Niels J.

    2011-01-01

    Theoretical work suggests that both negative frequency-dependent payoffs and state-dependent payoffs can lead to individual variation in behavioural plasticity. We investigated the roles of both frequency- and state-dependence on the occurrence of individual variation in behavioural plasticity in a

  17. The current and ideal state of anatomic pathology patient safety.

    Science.gov (United States)

    Raab, Stephen Spencer

    2014-01-01

    An anatomic pathology diagnostic error may be secondary to a number of active and latent technical and/or cognitive components, which may occur anywhere along the total testing process in clinical and/or laboratory domains. For the pathologist interpretive steps of diagnosis, we examine Kahneman's framework of slow and fast thinking to explain different causes of error in precision (agreement) and in accuracy (truth). The pathologist cognitive diagnostic process involves image pattern recognition and a slow thinking error may be caused by the application of different rationally-constructed mental maps of image criteria/patterns by different pathologists. This type of error is partly related to a system failure in standardizing the application of these maps. A fast thinking error involves the flawed leap from image pattern to incorrect diagnosis. In the ideal state, anatomic pathology systems would target these cognitive error causes as well as the technical latent factors that lead to error.

  18. Current state of epidemiological studies in Belarus about Chernobyl sufferers

    Energy Technology Data Exchange (ETDEWEB)

    Matsko, V.P. [Institute of Radiobiology, Academy Sciences of Belarus, Minsk (Belarus)

    1998-03-01

    The present paper is an analysis of the results of epidemiological studies in Belarus about the after-effects of the accident at the Chernobyl atomic power station (ChAPS), based on published data at scientific institutes, organs and institutions of Ministry of Health. In the last years the affected population showed thereby more significant - as compared with republican indices - growth of incidence in the majority of diseases (first of all: digestion, urogenital, nervous, endocrine systems, diseases of ear, throat, nose both among adults and among children). Aggravation of health state continues in the participants of liquidation of the ChAPS accident consequences and the evacuees from the alienation zone which have obtained considerable radiation load to organism (rise of incidence of diseases of endocrine, cardiovascular, nervous system etc.). Considerable growth of thyroid cancer incidence is registered in Belarus children and adolescents, especially in the Gomel and Brest regions. This is conditioned by dose commitments on thyroid gland due to iodine radionuclides in first period after the accident, incorrect iodine prophylaxy, and goitre endemic. The rise of hereditary pathology is registered too. An expressed increase of oncological diseases is observed therewith mainly in the Gomel region, especially in the districts with high level of radiocontamination and, consequently, significant radiation load. First of all, this relates to the growth of incidence of cancer of lungs, mammary gland, bladder. The analysis of epidemiological studies performed in Belarus after the ChAPS catastrophe and comparison of them with data obtained in the pre-Chernobyl period testify to the aggravation of health state of Belarus population. The specialists unambiguously recognize the direct influence of radioactive pollution in the environment on rise of thyroid pathologies, hereditary and congenial diseases, and cancers of different localizations. There is no unique opinion

  19. Precarious Employment in the Vologda Oblast: Current State and Trends

    Directory of Open Access Journals (Sweden)

    Aleksandr Mikhailovich Panov

    2016-09-01

    Full Text Available The paper is devoted to the study of the phenomenon of precarious employment in Russian regions. Today, the socio-economic sciences lack a single concept of precarious employment applicable to Russian conditions. Despite the considerable amount of scientific and practical works of domestic and foreign authors on the issue of precarious employment, the criteria of its statistical evaluation as applied to Russian conditions have not been determined. At the same time, the development of precarious employment threatens the country’s socio-economic welfare, because it creates the risk of unwanted effects such as poor employment, hidden and open unemployment, lower labor productivity, degradation of human capital, etc. The paper provides a brief review of research on the problem stated, and defines precarious employment. The author makes an attempt to determine and substantiate the list of indicators available in official statistics for assessing precarious employment in the region. The study allocates three blocks of indicators: indicators of institutional regulation, conditions of employment and functioning of the labor market. Based on these indicators, the author analyzes the status and trends of precarious work in the Vologda Oblast in the period from 2001 to 2015. In some cases, the author presents a comparative analysis of the data for the Russian Federation and Northwestern Federal District. The analysis has helped identify positive and negative changes in the field of precarious employment in the Vologda Oblast. In particular, the author identifies the following problems: an increase in the share of those employed in the informal sector, a relative increase in the number of the working poor, an almost three-fold growth of overdue debts on wages in comparable prices per worker. On the basis of this analysis, the author identifies the directions of the state policy that can help reduce precarious employment: development of information

  20. Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus

    Directory of Open Access Journals (Sweden)

    Morteza Maleki

    2017-05-01

    Conclusion: The current study findings indicated a cross state-dependent learning between SCO and morphine at CA1 level. Therefore, it seems that muscarinic and opioid receptors may act reciprocally on modulation of passive avoidance memory retrieval, at the level of dorsal hippocampus, in mice.

  1. Current State of Animal (Mouse Modeling in Melanoma Research

    Directory of Open Access Journals (Sweden)

    Omer F. Kuzu

    2015-01-01

    Full Text Available Despite the considerable progress in understanding the biology of human cancer and technological advancement in drug discovery, treatment failure remains an inevitable outcome for most cancer patients with advanced diseases, including melanoma. Despite FDA-approved BRAF-targeted therapies for advanced stage melanoma showed a great deal of promise, development of rapid resistance limits the success. Hence, the overall success rate of melanoma therapy still remains to be one of the worst compared to other malignancies. Advancement of next-generation sequencing technology allowed better identification of alterations that trigger melanoma development. As development of successful therapies strongly depends on clinically relevant preclinical models, together with the new findings, more advanced melanoma models have been generated. In this article, besides traditional mouse models of melanoma, we will discuss recent ones, such as patient-derived tumor xenografts, topically inducible BRAF mouse model and RCAS/TVA-based model, and their advantages as well as limitations. Although mouse models of melanoma are often criticized as poor predictors of whether an experimental drug would be an effective treatment, development of new and more relevant models could circumvent this problem in the near future.

  2. State-dependent cognition and its relevance to cultural evolution.

    Science.gov (United States)

    Nettle, Daniel

    2018-02-05

    Individuals cope with their worlds by using information. In humans in particular, an important potential source of information is cultural tradition. Evolutionary models have examined when it is advantageous to use cultural information, and psychological studies have examined the cognitive biases and priorities that may transform cultural traditions over time. However, these studies have not generally incorporated the idea that individuals vary in state. I argue that variation in state is likely to influence the relative payoffs of using cultural information versus gathering personal information; and also that people in different states will have different cognitive biases and priorities, leading them to transform cultural information in different ways. I explore hunger as one example of state variable likely to have consequences for cultural evolution. Variation in state has the potential to explain why cultural traditions and dynamics are so variable between individuals and populations. It offers evolutionarily-grounded links between the ecology in which individuals live, individual-level cognitive processes, and patterns of culture. However, incorporating heterogeneity of state also makes the modelling of cultural evolution more complex, particularly if the distribution of states is itself influenced by the distribution of cultural beliefs and practices. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Multi-temperature state-dependent equivalent circuit discharge model for lithium-sulfur batteries

    DEFF Research Database (Denmark)

    Propp, Karsten; Marinescu, Monica; Auger, Daniel J.

    2016-01-01

    pulse profile at four temperatures from 10 °C to 50 °C, giving linearized ECN parameters for a range of states-of-charge, currents and temperatures. These are used to create a nonlinear polynomial-based battery model suitable for use in a battery management system. When the model is used to predict......Lithium-sulfur (Li-S) batteries are described extensively in the literature, but existing computational models aimed at scientific understanding are too complex for use in applications such as battery management. Computationally simple models are vital for exploitation. This paper proposes a non......-linear state-of-charge dependent Li-S equivalent circuit network (ECN) model for a Li-S cell under discharge. Li-S batteries are fundamentally different to Li-ion batteries, and require chemistry-specific models. A new Li-S model is obtained using a ‘behavioural’ interpretation of the ECN model; as Li...

  4. Non-heart-beating donation: current state of the art.

    Science.gov (United States)

    Arias-Diaz, J; Alvarez, J; del Barrio, M R; Balibrea, J L

    2004-09-01

    The use of non-heart-beating donors (NHBD) helps us to deal with the problem of the organ shortage. In addition to difficulties with legal and ethical acceptability, there are concerns regarding medical safety, which prevent the widespread use of these donors. To make optimum use of this potential organ supply, the ischemic injury that occurs after a period of warm ischemia needs to be reversed. To minimize the warm ischemia time, once the subject is declared dead, most centers commence in situ cold perfusion via a femoral access or a rapid aortic cannulation. This usually occurs within minutes of arriving at the emergency department, before the next of kin have been notified of the patient's death. The European experience of kidney transplantation from NHBD shows promising results. The long-term outcomes are similar to HBD kidneys notwithstanding a higher rate of delayed graft function, which seems not to affect the long-term survival of these kidneys. In summary, NHBD may have an important impact on the large discrepancy that exists between the organ supply and the demand. Current data suggest that the results may be further improved by better patient selection and retrieval team organization.

  5. Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art

    Directory of Open Access Journals (Sweden)

    Amir H. Lebastchi

    2012-01-01

    Full Text Available Adrenocortical carcinoma (ACC is a rare, aggressive malignancy that generally conveys a poor prognosis. Currently, surgical resection is considered the lone curative treatment modality. In addition, the low prevalence of ACC has limited effective clinical trial design to develop evidence-based approaches to ACC therapy. The proper role of radio- and chemotherapy treatment for ACC is still being defined. Similarly, the molecular pathogenesis of ACC remains to be fully characterized. Despite these challenges, progress has been made in several areas. After years of refinement, an internationally accepted staging system has been defined. International collaborations have facilitated increasingly robust clinical trials, especially regarding agent choice and patient selection for chemotherapeutics. Genetic array data and molecular profiling have identified new potential targets for rational drug design as well as potential tumor markers and predictors of therapeutic response. However, these advances have not yet been translated into a large outcomes benefit for ACC patients. In this paper, we summarize established therapy for ACC and highlight recent findings in the field that are impacting clinical practice.

  6. PHYLLOID TUMORS OF MAMMARY GLANDS. CURRENT STATE OF THE PROBLEM

    Directory of Open Access Journals (Sweden)

    A. D. Zikiryakhodzhaev

    2017-01-01

    Full Text Available Phylloid (leaf-shaped breast tumors are a rare disease and constitute 0.3–0.5% of all breast tumors. Due to the rare frequency of occurrence, as well as the small number of randomized studies that have been conducted on this pathology, there is currently no standardized approach to the diagnosis and treatment of phylloid tumors. The reports about these rare cases appearing in the literature are, as a rule, descriptive, which only emphasizes the difficulty of differential diagnosis, the development of the correct tactics for treating such patients. In connection with the rarity, it is very difficult to diagnose correctly this pathology, which requires a highly qualified doctor as a diagnostician in the initial contact with such a patient, and a pathologist doctor who establishes the final morphological diagnosis. Often, leaf-shaped tumors are mistaken for mammary fibroadenomas. Such difficulties in correct diagnosis in the preoperative period can lead to errors in the planning of treatment. Also, the recommendations for the treatment of patients with this diagnosis are not fully understood, since up to now there are no accepted treatment standards in both Russian and foreign recommendations. Due to the fact that this pathology of mammary glands is rare, the principles of treatment are based on small retrospective studies and clinical observations. In this review, we will discuss the results of major retrospective studies, including data on epidemiology, etiology, diagnostic approach, strategies and results of treatment of this complex group of breast pathologies.

  7. The human proteome project: current state and future direction.

    Science.gov (United States)

    Legrain, Pierre; Aebersold, Ruedi; Archakov, Alexander; Bairoch, Amos; Bala, Kumar; Beretta, Laura; Bergeron, John; Borchers, Christoph H; Corthals, Garry L; Costello, Catherine E; Deutsch, Eric W; Domon, Bruno; Hancock, William; He, Fuchu; Hochstrasser, Denis; Marko-Varga, György; Salekdeh, Ghasem Hosseini; Sechi, Salvatore; Snyder, Michael; Srivastava, Sudhir; Uhlén, Mathias; Wu, Cathy H; Yamamoto, Tadashi; Paik, Young-Ki; Omenn, Gilbert S

    2011-07-01

    After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

  8. Review of the Current State of UAV Regulations

    Directory of Open Access Journals (Sweden)

    Claudia Stöcker

    2017-05-01

    Full Text Available UAVs—unmanned aerial vehicles—facilitate data acquisition at temporal and spatial scales that still remain unachievable for traditional remote sensing platforms. However, current legal frameworks that regulate UAVs present significant barriers to research and development. To highlight the importance, impact, and diversity of UAV regulations, this paper provides an exploratory investigation of UAV regulations on the global scale. For this, the methodological approach consists of a research synthesis of UAV regulations, including a thorough literature review and a comparative analysis of national regulatory frameworks. Similarities and contrasting elements in the various national UAV regulations are explored including their statuses from the perspectives of past, present, and future trends. Since the early 2000s, countries have gradually established national legal frameworks. Although all UAV regulations have one common goal—minimizing the risks to other airspace users and to both people and property on the ground—the results reveal distinct variations in all the compared variables. Furthermore, besides the clear presence of legal frameworks, market forces such as industry design standards and reliable information about UAVs as public goods are expected to shape future developments.

  9. Current state and recent developments of child psychiatry in China.

    Science.gov (United States)

    Zheng, Yi; Zheng, Xixi

    2015-01-01

    China has a population of 1.3 billion, of which 238 million are children under age 15. The rapid economic development and social reforms that have taken place in recent years all had a great influence on child and adolescent mental health. Though a nationwide prevalence study for child and adolescent mental disorders in China is lacking, several regional studies have shown the prevalence of mental disorders in children to be close to the worldwide prevalence of 20%. This article reviews the current status of Chinese child psychiatry, the prevalence of specific disorders in China and the influence of culture on the diagnosis and treatment of child and adolescent mental disorders. Several important social issues are also explored in detail, including the one child policy and left-behind children of migrating workers. Changes in family structures along with the growing competitions in life have weakened the traditional social support system. As a result childhood behavioral problems, mood disorders in young college students, substance abuse and youth suicide are all increasing in China. Many who suffer from mental disorders are not adequately cared for because the scarcity of qualified service providers and pathways to care. This article also lists some challenges and possible solutions, including the multidisciplinary and culture sensitive service model for child mental health. Relevant laws, policies and regulations are also introduced.

  10. Injection current dependences of electroluminescence transition energy in InGaN/GaN multiple quantum wells light emitting diodes under pulsed current conditions

    International Nuclear Information System (INIS)

    Zhang, Feng; Ikeda, Masao; Liu, Jianping; Zhang, Shuming; Zhou, Kun; Yang, Hui; Liu, Zongshun

    2015-01-01

    Injection current dependences of electroluminescence transition energy in blue InGaN/GaN multiple quantum wells light emitting diodes (LEDs) with different quantum barrier thicknesses under pulsed current conditions have been analyzed taking into account the related effects including deformation caused by lattice strain, quantum confined Stark effects due to polarization field partly screened by carriers, band gap renormalization, Stokes-like shift due to compositional fluctuations which are supposed to be random alloy fluctuations in the sub-nanometer scale, band filling effect (Burstein-Moss shift), and quantum levels in finite triangular wells. The bandgap renormalization and band filling effect occurring at high concentrations oppose one another, however, the renormalization effect dominates in the concentration range studied, since the band filling effect arising from the filling in the tail states in the valence band of quantum wells is much smaller than the case in the bulk materials. In order to correlate the carrier densities with current densities, the nonradiative recombination rates were deduced experimentally by curve-fitting to the external quantum efficiencies. The transition energies in LEDs both with 15 nm quantum barriers and 5 nm quantum barriers, calculated using full strengths of theoretical macroscopic polarization given by Barnardini and Fiorentini [Phys. Status Solidi B 216, 391 (1999)] are in excellent accordance with experimental results. The LED with 5 nm barriers has been shown to exhibit a higher transition energy and a smaller blue shift than those of LED with 15 nm barriers, which is mainly caused by the smaller internal polarization field in the quantum wells

  11. Injection current dependences of electroluminescence transition energy in InGaN/GaN multiple quantum wells light emitting diodes under pulsed current conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Feng; Ikeda, Masao, E-mail: mikeda2013@sinano.ac.cn; Liu, Jianping; Zhang, Shuming [Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123 (China); Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123 (China); Zhou, Kun; Yang, Hui [Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123 (China); Key Lab of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (CAS), Suzhou 215123 (China); Institute of Semiconductors (CAS), Beijing 100083 (China); Liu, Zongshun [Institute of Semiconductors (CAS), Beijing 100083 (China)

    2015-07-21

    Injection current dependences of electroluminescence transition energy in blue InGaN/GaN multiple quantum wells light emitting diodes (LEDs) with different quantum barrier thicknesses under pulsed current conditions have been analyzed taking into account the related effects including deformation caused by lattice strain, quantum confined Stark effects due to polarization field partly screened by carriers, band gap renormalization, Stokes-like shift due to compositional fluctuations which are supposed to be random alloy fluctuations in the sub-nanometer scale, band filling effect (Burstein-Moss shift), and quantum levels in finite triangular wells. The bandgap renormalization and band filling effect occurring at high concentrations oppose one another, however, the renormalization effect dominates in the concentration range studied, since the band filling effect arising from the filling in the tail states in the valence band of quantum wells is much smaller than the case in the bulk materials. In order to correlate the carrier densities with current densities, the nonradiative recombination rates were deduced experimentally by curve-fitting to the external quantum efficiencies. The transition energies in LEDs both with 15 nm quantum barriers and 5 nm quantum barriers, calculated using full strengths of theoretical macroscopic polarization given by Barnardini and Fiorentini [Phys. Status Solidi B 216, 391 (1999)] are in excellent accordance with experimental results. The LED with 5 nm barriers has been shown to exhibit a higher transition energy and a smaller blue shift than those of LED with 15 nm barriers, which is mainly caused by the smaller internal polarization field in the quantum wells.

  12. The French Accelerometer Network (RAP): Current state in 2007

    International Nuclear Information System (INIS)

    Gueguen, P.; Bard, P.-Y.; Pequegnat, C.; Souriau, A.; Dominique, P.; Regnier, M.

    2007-01-01

    France is a country of moderate seismicity but, due to dense urbanized and industrial areas, the seismic risk is significant. Furthermore, recent developments in numerical and semi-empirical methods requires a good knowledge of several parameters. The mission of the French accelerometer network programme (RAP-Reseau Accelerometrique Permanent) is to expand and modernize significantly the acquisition and application of French accelerometer data (both strong and weak motion) in order to improve earthquake related research and public safety from earthquakes. This network is the result of co-operative efforts including academic institutions (INSU-CNRS, Universities of Grenoble, Nice, Strasbourg, Toulouse, IPG Paris) and several state agencies (BRGM, CEA, IRSN, LCPC). Since 1995, around 120 stations have been installed in some seismic areas of France. This network also includes specific research actions (site effects, building monitoring, deep borehole). Other French accelerometer stations devoted to strong motion recording are also associated to the network. All data are archived and freely distributed in a database center, data being available in SAC, ASCII and SEED format. (authors)

  13. Current state of seagrass ecosystem services: Research and policy integration

    KAUST Repository

    Ruiz-Frau, A.

    2017-10-12

    Seagrasses contribute to the maintenance of human wellbeing. However certain aspects of their role as ecosystem service (ES) providers remain understudied. Here, we synthesise the state of seagrass ES (SGES) research and policy implications. Additionally, we recommend ways in which SGES research can be integrated in to policy design, by drawing lessons from the case of Blue Carbon (BC). SGES research suffers from three main biases: a geographical bias, SGES has been restricted to chartered seagrass areas; a type of service research bias, provisioning and regulating services have received extensive attention while cultural services remain understudied; a type of discipline bias, the ecological aspects of SGES have been well documented while economic and social aspects remain in comparison understudied. These are particularly important, as an understanding of the social and economic considerations of the provision of ES is fundamental to facilitate its integration into policy frameworks. Lessons drawn from the operationalization process of BC show the reoccurrence of certain aspects that have enabled the integration of BC into policy. These aspects are grouped under 4 different categories. From the analysis of these elements we draw lessons that could facilitate the operationalization of other ecosystem services and their incorporation into management policy frameworks.

  14. Current state of web accessibility of Malaysian ministries websites

    Science.gov (United States)

    Ahmi, Aidi; Mohamad, Rosli

    2016-08-01

    Despite the fact that Malaysian public institutions have progressed considerably on website and portal usage, web accessibility has been reported as one of the issues deserves special attention. Consistent with the government moves to promote an effective use of web and portal, it is essential for the government institutions to ensure compliance with established standards and guidelines on web accessibility. This paper evaluates accessibility of 25 Malaysian ministries websites using automated tools i.e. WAVE and Achecker. Both tools are designed to objectively evaluate web accessibility in conformance with Web Content Accessibility Guidelines 2.0 (WCAG 2.0) and United States Rehabilitation Act 1973 (Section 508). The findings reported somewhat low compliance to web accessibility standard amongst the ministries. Further enhancement is needed in the aspect of input elements such as label and checkbox to be associated with text as well as image-related elements. This findings could be used as a mechanism for webmasters to locate and rectify errors pertaining to the web accessibility and to ensure equal access of the web information and services to all citizen.

  15. Current state of utilization of nuclear sources for district heating

    International Nuclear Information System (INIS)

    Zlatnansky, J.

    1987-01-01

    The use of heat from nuclear power sources is considered as the basic trend of development in district heating within the framework of the long-term prospective plan of the development of the fuel and power complex in the CSSR. Of the total consumption of heat in the year 2005 (648,000 TJ), nuclear power units are to deliver 54,000 TJ. At present, heat is being generated by the Jaslovske Bohunice nuclear power plant and supplied to Trnava, and a heat duct is being built from this plant to Leopoldov and Hlohovce, and prospectively to Bratislava. The Dukovany nuclear power plant is expected to supply heat to Brno, the Mochovce nuclear power plant to Levice and Nitra, and the Temelin nuclear power plant to Ceske Budejovice. Other nuclear power plants will in the future also supply heat (Kecerovce, Blahutovice and Opatovice). The technical and economic evaluation is tabulated of heat deliveries from all said nuclear power plants. It is stated that after the year 2000, AST 500 nuclear heating plants should be deployed for supplying heat to areas out of reach of nuclear power plants and reconstructed fossil-fuel power plants. (Z.M.). 2 tabs

  16. The Current State of Additive Manufacturing in Wind Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Mann, Margaret [National Renewable Energy Lab. (NREL), Golden, CO (United States); Palmer, Sierra [Worcester Polytechnic Institute (WPI), , Worcester, MA (United States); Lee, Dominic [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kurup, Parthiv [National Renewable Energy Lab. (NREL), Golden, CO (United States); Remo, Timothy [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenne, Dale Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Richardson, Bradley S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Love, Lonnie J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Post, Brian K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-12-01

    Wind power is an inexhaustible form of energy that is being captured throughout the U.S. to power the engine of our economy. A robust, domestic wind industry promises to increase U.S. industry growth and competitiveness, strengthen U.S. energy security independence, and promote domestic manufacturing nationwide. As of 2016, ~82GW of wind capacity had been installed, and wind power now provides more than 5.5% of the nation’s electricity and supports more than 100,000 domestic jobs, including 500 manufacturing facilities in 43 States. To reach the U.S. Department of Energy’s (DOE’s) 2015 Wind Vision study scenario of wind power serving 35% of the nation's end-use demand by 2050, significant advances are necessary in all areas of wind technologies and market. An area that can greatly impact the cost and rate of innovation in wind technologies is the use of advanced manufacturing, with one of the most promising areas being additive manufacturing (AM). Considering the tremendous promise offered by advanced manufacturing, it is the purpose of this report to identify the use of AM in the production and operation of wind energy systems. The report has been produced as a collaborative effort for the DOE Wind Energy Technology Office (WETO), between Oak Ridge National Laboratory (ORNL) and the National Renewable Energy Laboratory (NREL).

  17. Poliomyelitis in the United States: A Historical Perspective and Current Vaccination Policy.

    Science.gov (United States)

    Farizo, Karen M.; And Others

    1990-01-01

    Examines poliomyelitis in the United States by reviewing clinical manifestations and outcomes, history, recent epidemiologic characteristics, characteristics of currently available vaccines, controversies surrounding vaccination policy, current poliovirus vaccination recommendations, and prospects for worldwide eradication. Poliomyelitis remains…

  18. Past residence outside of the United States is associated with diet quality in adults currently residing in the United States.

    Science.gov (United States)

    Frankenfeld, Cara L; Poudrier, Jill; Waters, Nigel; Gillevet, Patrick M

    2014-01-01

    To evaluate healthy dietary factors in relation to prior residence outside the United States (US) among university-affiliated individuals currently residing in the US. Current diet information was collected via a 4-day food record and residential history data were collected by in-person interview for 114 individuals. Residence outside of the US at any point during the interviewee's life was associated with higher diet quality (Healthy Eating Index-2005: 50.0 vs. 46.8) and lower added sugar intake (25.8 vs. 34.9 g/d). Concordance of residence as a child (≤12 years of age) and within the prior 5 years was more strongly associated with higher HEI-2005 score (52.7) than if childhood was outside of the US and recent within the US (47.1), compared with individuals who have only resided within the US (46.9). Results were similar when also accounting for self-reported current residence as permanent residence. Current diet quality, food groups, and nutrient intakes differed depending on where in the world region individuals resided as a child. Restricting the analyzes to a subgroup of individuals of younger age and similar education attenuated associations. Lower added sugar intake and higher overall diet quality were most consistently associated with residence outside of the US, and recent residence outside of the US may be more strongly associated than childhood residence. Some of these differences may be explained by demographic or socioeconomic factors. Future studies could evaluate explanatory factors for these observations, including detailed socioeconomic factors, exposure to diverse foods, and accessibility of processed foods. Copyright © 2013 Wiley Periodicals, Inc.

  19. Current state of development of the European Drought Observatory

    Science.gov (United States)

    Niemeyer, S.; de Jager, A.; Kurnik, B.; Laguardia, G.; Magni, D.; Nitcheva, O.; Rossi, S.; Weissteiner, C.

    2009-04-01

    The Joint Research Centre of the European Commission (JRC) is developing the prototype of the European Drought Observatory (EDO) for drought forecasting, detection, and monitoring in Europe. EDO is conceived as a web-based information system (http://edo.jrc.ec.europa.eu), integrating information from various sources and disciplines relevant to monitor and detect droughts throughout Europe. The prototype is currently performing the pre-operational production of drought indices using meteorological information, modelled hydrological parameters, and remote sensing data. In particular, the Standardized Precipitation Index (SPI) shows the general precipitation status according to the historical average in the predefined period. SPI in monthly step is calculated for the 1, 3, 6, 9 and 12 months averaging periods. Soil moisture estimations are produced daily by the LISFLOOD hydrological model, along with their anomalies and seven days forecasts. Two satellite remote sensing drought indicators are produced: Normalized Difference Water Index (NDWI) and Fraction of Absorbed Photosynthetic Active Radiation (fAPAR) anomalies. NDWI 10-day composites are obtained daily from Moderate Resolution Imaging Spectroradiometer (MODIS) data, while fAPAR anomalies are calculated from 10-day composites delivered by the European Space Agency (ESA) and estimated from Medium Resolution Imaging Spectrometer Instrument (MERIS) data. All these drought indicators are made available online for visualization and querying by means of a map viewer based on University of Minnesota MapServer and Oracle. The tool generates maps of the different indicators and provides functionalities to browse the maps, query the data, produce graphs, and output the maps in various formats.

  20. Nabarlek Traditional Owners' perspective on the current state of revegetation

    International Nuclear Information System (INIS)

    Lewis, B.

    2001-01-01

    Aboriginal people derive their identity from an ancestral relationship to land mediated through a traditional form of land title. This relationship to country determines a group or individual's place in the complex of law, ceremony, culture, responsibility, status, marriage, income etc (often collectively termed 'culture'), that is the essential corollary of traditional land tenure. In effect, country bestows upon Traditional Owners a place in the scheme of things as do social and occupational status, racial origin, financial position etc upon the Westerner. It is a critical link in the preservation of Aboriginal society, and pressure on or erosion of this relationship imposes further strain on the significant burden to Traditional Owners of cultural maintenance. In order that disenfranchisement does not occur because of the mining process, Traditional Owners must have a guarantee that the country will be returned to a pre-mining state as far as possible. This is certainly a significant part of the initial discussion of any consent (under the Aboriginal Land Rights (Northern Territory) Act, 1976). Among the worst outcomes for Aboriginal people involved in the mining process is the return to them of degraded lands, an indication to them that the Westerners who initially placed such great value on it no longer do so. These people are left with the mess or the scraps and perhaps for them the least traumatic course is to walk away, to pretend that the mined-out country is of no importance to them and that there is no pain. The rehabilitation of Nabarlek is in some ways a special case. There was a fairly long period from 1988 to 1994 in which nothing happened. At the final decision to close the operation much of the infrastructure was no longer useable. Initially there was ascribed certain value to plant and equipment items that did not really eventuate for Traditional Owners. Significant portions of the remnant infrastructure was handed back to Traditional Owners

  1. Current state and future prospects of remedial soil protection. Background

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, Joerg

    2009-08-15

    The legal basis for soil protection in the Federal Republic of Germany is: -The Act on Protection against Harmful Changes to Soil and on Rehabilitation of Contaminated Sites (Federal Soil Protection Act) (Bundes-Bodenschutzgesetz - BBodSchG) of 1998 [1] -The Federal Soil Protection and Contaminated Sites Ordinance (BBodSchV) of 1999 [2]. In Germany, the Federal Government has legislative competence in the field of soil protection. The Lander (German federal states), in turn, are responsible for enforcement of the BBodSchG and the BBodSchV; they may also issue supplementary procedural regulations. According to Article 1 BBodschG, the purpose of the Act is inter alia to protect and restore the functions of the soil on a permanent sustainable basis. These actions shall include prevention of harmful soil changes as well as rehabilitating soil, contaminated sites and waters contaminated by such sites in such a way that any contamination remains permanently below the hazard threshold. Whilst prevention aims to protect and preserve soil functions on a long-term basis, the object of remediation is mainly to avert concrete hazards in a spatial, temporal and manageable causative context. ''Remedial soil protection'' encompasses a tiered procedure in which a suspicion is verified successively and with least-possible effort and in which the circumstances of the individual case at hand are taken into account in deciding whether or not a need for remediation exists. It comprises the systematic stages of identifying, investigating and assessing suspect sites and sites suspected of being contaminated with a view to their hazard potential, determining whether remediation is necessary, remediating identified harmful soil changes and contaminated sites, and carrying out, where necessary, aftercare measures following final inspection of the remedial measure. (orig.)

  2. Density dependence of 2p-2h meson-exchange currents

    Science.gov (United States)

    Amaro, J. E.; Barbaro, M. B.; Caballero, J. A.; De Pace, A.; Donnelly, T. W.; Megias, G. D.; Ruiz Simo, I.

    2017-06-01

    We analyze the density dependence of the contribution of meson-exchange currents to the lepton-nucleus inclusive cross section in the two-particle two-hole channel. The model is based on the relativistic Fermi gas, where each nucleus is characterized by its Fermi momentum kF. We find that the 2p-2h nuclear response functions at their peaks scale as A kF2 for Fermi momentum going from 200 to 300 MeV/c and momentum transfer q from 2 kF to 2 GeV /c . This behavior is different from what is found for the quasielastic response, which scales as A /kF . Additionally, the deep scaling region is also discussed and there the usual scaling behavior is found to be preferable.

  3. Thermal state of the general time-dependent harmonic oscillator

    Indian Academy of Sciences (India)

    Taking advantage of dynamical invariant operator, we derived quantum mechanical solution of general time-dependent harmonic oscillator. ... The domain part of the email address of all email addresses used by the office of Indian Academy of Sciences, including those of the staff, the journals, various programmes, and ...

  4. Inhalant Abuse and Dependence among Adolescents in the United States

    Science.gov (United States)

    Wu, Li-Tzy; Pilowsky, Daniel J.; Schlenger, William E.

    2004-01-01

    Objective: To examine the patterns of inhalant use and correlates of the progression from inhalant use to abuse and dependence among adolescents aged 12 to 17. Method: Study data were drawn from the 2000 and 2001 National Household Surveys on Drug Abuse. Multinominal logistic regression was used to identify the characteristics associated with…

  5. Current oscillations in a metallic ring threaded by a time-dependent magnetic flux

    Science.gov (United States)

    Arrachea, Liliana

    2002-07-01

    We study a mesoscopic metallic ring threaded by a magnetic flux which varies linearly in time ΦM(t)=Φt with a formalism based in Baym-Kadanoff-Keldysh nonequilibrium Green functions. We propose a method to calculate the Green functions in real space and we consider an experimental setup to investigate the dynamics of the ring by recourse to a transport experiment. This consists of a single lead connecting the ring to a particle reservoir. We show that different dynamical regimes are attained depending on the ratio ħΦ/Φ0W, with Φ0=hc/e and W the bandwidth of the ring. For moderate lengths of the ring, a stationary regime is achieved for ħΦ/Φ0>W. In the opposite case with ħΦ/Φ0<=W, the effect of Bloch oscillations driven by the induced electric field manifests itself in the transport properties of the system. In particular, we show that in this time-dependent regime a tunneling current oscillating in time with a period τ=2πΦ0/Φ can be measured in the lead. We also analyze the resistive effect introduced by inelastic scattering due to the coupling to the external reservoir.

  6. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

    International Nuclear Information System (INIS)

    Luo, Jialie; Li, Wenming; Liu, Yuwei; Zhang, Wei; Fu, Hongjun; Lee, Nelson T.K.; Yu, Hua; Pang, Yuanping; Huang, Pingbo; Xia, Jun; Li, Zhi-Wang; Li, Chaoying; Han, Yifan

    2007-01-01

    Bis(7)-tacrine has been shown to prevent glutamate-induced neuronal apoptosis by blocking NMDA receptors. However, the characteristics of the inhibition have not been fully elucidated. In this study, we further characterize the features of bis(7)-tacrine inhibition of NMDA-activated current in cultured rat hippocampal neurons. The results show that with the increase of extracellular pH, the inhibitory effect decreases dramatically. At pH 8.0, the concentration-response curve of bis(7)-tacrine is shifted rightwards with the IC 50 value increased from 0.19 ± 0.03 μM to 0.41 ± 0.04 μM. In addition, bis(7)-tacrine shifts the proton inhibition curve rightwards. Furthermore, the inhibitory effect of bis(7)-tacrine is not altered by the presence of the NMDA receptor proton sensor shield spermidine. These results indicate that bis(7)-tacrine inhibits NMDA-activated current in a pH-dependent manner by sensitizing NMDA receptors to proton inhibition, rendering it potentially beneficial therapeutic effects under acidic conditions associated with stroke and ischemia

  7. Combination Treatment for Nicotine Dependence: State of the Science

    OpenAIRE

    INGERSOLL, KAREN S.; COHEN, JESSYE

    2005-01-01

    Both nicotine replacement and sustained-release buproprion double the odds of achieving short- and moderate-term abstinence from nicotine. However, questions remain about the efficacy of combining pharmacotherapies. Our purposes were to review the evidence for (1) combined pharmacotherapy and (2) multimodal treatment combining pharmacotherapy and behavioral treatment and to recommend combinations of treatments to reduce nicotine dependence. Combining first-line pharmacotherapies with each oth...

  8. The impact of self-reported life stress on current impulsivity in cocaine dependent adults

    Science.gov (United States)

    Ross, Elizabeth L.; Yoon, Jin H.; Mahoney, James J.; Omar, Yasmine; Newton, Thomas F.; De La Garza, Richard

    2014-01-01

    Current cocaine treatments may be enhanced with a better understanding of the underlying mechanisms that contribute to the onset and maintenance of the disease, such as life stress and impulsivity. Life stress and impulsivity have previously been studied independently as contributors to drug use, and the current study expands upon past research by examining how these factors interact with one another. The aim of the current study was to evaluate the role of life stress in predicting impulsivity in a non-treatment seeking cocaine-dependent sample (N = 112). Analyses revealed that trait impulsivity (as measured by the Barratt Impulsiveness Scale) was associated with education (r = −3.09, p the age of 30 demonstrated lower impulsivity in decision-making (as measured by delay discounting) than those under 30 (t = 2.21, p = 0.03). Overall exposure to life stress was not significantly correlated to either aspect of impulsivity. However several specific life stressors were significantly related to greater impulsivity including having been put up for adoption or in foster care (t = −2.96, p < 0.01), and having a child taken away against their will (t = −2.68, p = 0.01). These findings suggest that age and education relate to impulsivity; and that while an overall compilation of life stress scores was not related to impulsivity, specific types of stress related to either being taken away from a parent or having a child taken away were. Future studies should assess these constructs longitudinally to restrict response bias. PMID:23796525

  9. A new temperature-dependent equation of state of solids

    Indian Academy of Sciences (India)

    The equation of state (EOS) of condensed matter is important in many fields of basic and applied sciences including physics and geophysics. To explain an EOS and other thermodynamical properties of a substance, it is essential to study the forces between atoms and molecules. The exact evaluation of these forces from ...

  10. Stress-strain state of pipeline depending on complicated environment

    Science.gov (United States)

    Burkov, P. V.; Filimonenko, M. A.; Burkova, S. P.

    2016-09-01

    The paper presents the 3D model and FEM analysis of the stress-strain state of the soil- pipe interaction system. The analysis shows that the geological environment has shown a strong effect on the pipelines. This stress-strain analysis is carried out using the ANSYS finite element program.

  11. Size dependent deactivation of the excited state of DHICA

    DEFF Research Database (Denmark)

    Gauden, Magdalena; Pezzella, Alessandro; Panzella, Lucia

    2008-01-01

    Melanin is a natural pigment mainly responsible for the protection of skin and eyes from UV damage. 5,6- dihydroxyindole- 2 carboxylic acid (DHICA) is a key melanin building block. We have investigated the excited state dynamics of DHICA as well as its derivatives and oligomeric units using...

  12. Viewing International Students as State Stimulus Potential: Current Perceptions and Future Possibilities

    Science.gov (United States)

    Owens, Deborah L.; Srivastava, Prashant; Feerasta, Aniqa

    2011-01-01

    In this difficult economic climate state policy makers are increasingly focused on higher education as an economic development tool. Many rust belt states are looking to transform themselves from a state dependent on manufacturing and agriculture to a more diverse knowledge based economy. Many nations use higher education as a catalyst for…

  13. State-dependent Jastrow correlation functions for {sup 4}He nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Guardiola, R. [Departamento de Fisica Atomica, Molecular i Nuclear, Universitat de Valencia, Avda. Dr Moliner 50, E-46100 Burjassot, Valencia (Spain); Portesi, M. [IFIC, Centre Mixt: CSIC - Universitat de Valencia, Avda. Dr Moliner 50, E-46100 Burjassot, Valencia (Spain)

    1998-04-01

    We calculate the ground-state energy for the nucleus {sup 4}He with V4 nucleon interactions, making use of a Jastrow description of the corresponding wavefunction with state-dependent correlation factors. The effect related to the state dependence of the correlation is quite important, lowering the upper bound for the ground-state energy by some 2 MeV. (author). Letter-to-the-editor.

  14. The reaction current distribution in battery electrode materials revealed by XPS-based state-of-charge mapping.

    Science.gov (United States)

    Pearse, Alexander J; Gillette, Eleanor; Lee, Sang Bok; Rubloff, Gary W

    2016-07-28

    Morphologically complex electrochemical systems such as composite or nanostructured lithium ion battery electrodes exhibit spatially inhomogeneous internal current distributions, particularly when driven at high total currents, due to resistances in the electrodes and electrolyte, distributions of diffusion path lengths, and nonlinear current-voltage characteristics. Measuring and controlling these distributions is interesting from both an engineering standpoint, as nonhomogenous currents lead to lower utilization of electrode material, as well as from a fundamental standpoint, as comparisons between theory and experiment are relatively scarce. Here we describe a new approach using a deliberately simple model battery electrode to examine the current distribution in a electrode material limited by poor electronic conductivity. We utilize quantitative spatially resolved X-ray photoelectron spectroscopy to measure the spatial distribution of the state-of-charge of a V2O5 model electrode as a proxy measure for the current distribution on electrodes discharged at varying current densities. We show that the current at the electrode-electrolyte interface falls off with distance from the current collector, and that the current distribution is a strong function of total current. We compare the observed distributions with a simple analytical model which reproduces the dependence of the distribution on total current, but fails to predict the correct length scale. A more complete numerical simulation suggests that dynamic changes in the electronic conductivity of the V2O5 concurrent with lithium insertion may contribute to the differences between theory and experiment. Our observations should help inform design criteria for future electrode architectures.

  15. Temperature impact on the tunnel fet off-state current components

    Science.gov (United States)

    Agopian, Paula Ghedini Der; Martino, Márcio Dalla Valle; Filho, Sebastião Gomes dos Santos; Martino, João Antonio; Rooyackers, Rita; Leonelli, Daniele; Claeys, Cor

    2012-12-01

    In this work, the temperature impact on the off-state current components is analyzed through numerical simulation and experimentally. First of all, the band-to-band tunneling is studied by varying the underlap in the channel/drain junction, leading to an analysis of the different off-state current components. For pTFET devices, the best behavior for off-state current was obtained for higher values of underlap (reduced BTBT) and at low temperatures (reduced SRH and TAT). At high temperature, an unexpected off-state current occurred due to the thermal leakage current through the drain/channel junction. Besides, these devices presented a good performance when considering the drain current as a function of the drain voltage, making them suitable for analog applications.

  16. Party Finances: Between Dependence on the State and Its Embezzlement

    Directory of Open Access Journals (Sweden)

    Cristina Matiuța

    2018-03-01

    Full Text Available The article aims to analyze the financial behavior of political parties in Romania and the revenues collected in recent years, on the basis of available official data, as well as the practices of embezzling public money and using state resources for electoral purposes, by referring to several corruption scandals related to their funding. It suggests that, as laws became clearer and more restrictive, the methods of those engaged in corrupt practices seem to be refined as well and that a coherent legal framework along with the firm punishment of those guilty of violating laws could lessen the scourge of corruption.

  17. Combination treatment for nicotine dependence: state of the science.

    Science.gov (United States)

    Ingersoll, Karen S; Cohen, Jessye

    2005-01-01

    Both nicotine replacement and sustained-release buproprion double the odds of achieving short- and moderate-term abstinence from nicotine. However, questions remain about the efficacy of combining pharmacotherapies. Our purposes were to review the evidence for (1) combined pharmacotherapy and (2) multimodal treatment combining pharmacotherapy and behavioral treatment and to recommend combinations of treatments to reduce nicotine dependence. Combining first-line pharmacotherapies with each other or with investigational drugs shows little benefit. In contrast, trials combining specific behavioral treatments with first-line pharmacotherapies show enhanced smoking cessation rates, but benefits are not seen in all populations. We recommend future directions for research, including better specification of behavioral components and further examination of the length and timing of treatment.

  18. The role of relativity in the optical response of gold within the time-dependent current-density-functional theory.

    Science.gov (United States)

    Romaniello, P; de Boeij, P L

    2005-04-22

    We included relativistic effects in the formulation of the time-dependent current-density-functional theory for the calculation of linear response properties of metals [P. Romaniello and P. L. de Boeij, Phys. Rev. B (to be published)]. We treat the dominant scalar-relativistic effects using the zeroth-order regular approximation in the ground-state density-functional theory calculations, as well as in the time-dependent response calculations. The results for the dielectric function of gold calculated in the spectral range of 0-10 eV are compared with experimental data reported in literature and recent ellipsometric measurements. As well known, relativistic effects strongly influence the color of gold. We find that the onset of interband transitions is shifted from around 3.5 eV, obtained in a nonrelativistic calculation, to around 1.9 eV when relativity is included. With the inclusion of the scalar-relativistic effects there is an overall improvement of both real and imaginary parts of the dielectric function over the nonrelativistic ones. Nevertheless some important features in the absorption spectrum are not well reproduced, but can be explained in terms of spin-orbit coupling effects. The remaining deviations are attributed to the underestimation of the interband gap (5d-6sp band gap) in the local-density approximation and to the use of the adiabatic local-density approximation in the response calculation.

  19. Two Dimensional Steady State Eddy Current Analysis of a Spinning Conducting Cylinder

    Science.gov (United States)

    2017-03-09

    UNCLASSIFIED UNCLASSIFIED AD-E403 855 Technical Report ARMET-TR-16045 TWO- DIMENSIONAL STEADY-STATE EDDY CURRENT ANALYSIS OF A...August 2014 4. TITLE AND SUBTITLE TWO- DIMENSIONAL STEADY-STATE EDDY CURRENT ANALYSIS OF A SPINNING CONDUCTING CYLINDER 5a. CONTRACT NUMBER 5b...analytical closed-form analysis performed by Michael P. Perry and Thomas B. Jones (ref. 4). Two- dimensional (2D) finite element steady state analyses

  20. Mentoring and New Teacher Induction in the United States: A Review and Analysis of Current Practices

    Science.gov (United States)

    Bullough, Robert V., Jr.

    2012-01-01

    In this article, current practices were reviewed in mentoring and induction across three large states--New York, Texas, and California--and one small state, Utah. Patterns and trends are described in the United States, program results and evolving views of mentoring are discussed, gaps in the research literature are identified, and the future of…

  1. Dependence of the colored frequency noise in spin torque oscillators on current and magnetic field

    International Nuclear Information System (INIS)

    Eklund, Anders; Sani, Sohrab R.; Chung, Sunjae; Amir Hossein Banuazizi, S.; Östling, Mikael; Gunnar Malm, B.; Bonetti, Stefano; Majid Mohseni, S.; Persson, Johan; Iacocca, Ezio; Åkerman, Johan

    2014-01-01

    The nano-scale spin torque oscillator (STO) is a compelling device for on-chip, highly tunable microwave frequency signal generation. Currently, one of the most important challenges for the STO is to increase its longer-time frequency stability by decreasing the 1/f frequency noise, but its high level makes even its measurement impossible using the phase noise mode of spectrum analyzers. Here, we present a custom made time-domain measurement system with 150 MHz measurement bandwidth making possible the investigation of the variation of the 1/f as well as the white frequency noise in a STO over a large set of operating points covering 18–25 GHz. The 1/f level is found to be highly dependent on the oscillation amplitude-frequency non-linearity and the vicinity of unexcited oscillation modes. These findings elucidate the need for a quantitative theoretical treatment of the low-frequency, colored frequency noise in STOs. Based on the results, we suggest that the 1/f frequency noise possibly can be decreased by improving the microstructural quality of the metallic thin films

  2. Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states.

    Science.gov (United States)

    Friedman, Allyson K; Zhurov, Yuriy; Ludwar, Bjoern Ch; Weiss, Klaudiusz R

    2009-12-01

    Network outputs elicited by a specific stimulus may differ radically depending on the momentary network state. One class of networks states-experience-dependent states-is known to operate in numerous networks, yet the fundamental question concerning the relative role that inputs and states play in determining the network outputs remains to be investigated in a behaviorally relevant manner. Because previous work indicated that in the isolated nervous system the motor outputs of the Aplysia feeding network are affected by experience-dependent states, we sought to establish the behavioral relevance of these outputs. We analyzed the phasing of firing of radula opening motoneurons (B44 and B48) relative to other previously characterized motoneurons. We found that the overall pattern of motoneuronal firing corresponds to the phasing of movements during feeding behavior, thus indicating a behavioral relevance of network outputs. Previous studies suggested that network inputs act to trigger a response rather than to shape its characteristics, with the latter function being fulfilled by network states. We show this is an oversimplification. In a rested state, different inputs elicited distinct responses, indicating that inputs not only trigger but also shape the responses. However, depending on the combination of inputs and states, responses were either dramatically altered by the network state or were indistinguishable from those observed in the rested state. We suggest that the relative contributions of inputs and states are dynamically regulated and, rather than being fixed, depend on the specifics of states and inputs.

  3. Singular Hopf bifurcation in a differential equation with large state-dependent delay.

    Science.gov (United States)

    Kozyreff, G; Erneux, T

    2014-02-08

    We study the onset of sustained oscillations in a classical state-dependent delay (SDD) differential equation inspired by control theory. Owing to the large delays considered, the Hopf bifurcation is singular and the oscillations rapidly acquire a sawtooth profile past the instability threshold. Using asymptotic techniques, we explicitly capture the gradual change from nearly sinusoidal to sawtooth oscillations. The dependence of the delay on the solution can be either linear or nonlinear, with at least quadratic dependence. In the former case, an asymptotic connection is made with the Rayleigh oscillator. In the latter, van der Pol's equation is derived for the small-amplitude oscillations. SDD differential equations are currently the subject of intense research in order to establish or amend general theorems valid for constant-delay differential equation, but explicit analytical construction of solutions are rare. This paper illustrates the use of singular perturbation techniques and the unusual way in which solvability conditions can arise for SDD problems with large delays.

  4. The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors.

    Science.gov (United States)

    Rezayof, A; Khajehpour, L; Zarrindast, M R

    2009-05-05

    The current study was conducted to examine the involvement of muscarinic acetylcholine receptors of the amygdala in morphine-induced state-dependent memory retrieval. Male Wistar rats implanted bilaterally with cannulas in the amygdala were submitted to a step-through type passive avoidance task, and tested 24 h after training to measure step-through latency. Post-training s.c. administration of morphine at the doses of 5 and 7.5 mg/kg impaired the memory on the test day, which was restored when the same doses of morphine were used as a pre-test drug. This phenomenon is well known as morphine-induced state-dependent memory retrieval. Bilateral microinjection of the non-selective muscarinic acetylcholine receptor agonist, pilocarpine (0.25 and 0.5 microg/side), into the amygdala with an ineffective dose of morphine (0.5 mg/kg s.c.) significantly improved the memory retrieval and mimicked the effects of pre-test administration of a higher dose of morphine. It should be noted that in the animals that received saline after training and tested following intra-amygdala administration of pilocarpine (0.125, 0.25 and 0.5 microg/side) and those which received post-training morphine (7.5 mg/kg s.c.) and pre-test intra-amygdala microinjection of the same doses of pilocarpine, no significant change was observed in the step-through latencies. On the other hand, pre-test intra-amygdala microinjection of a selective muscarinic acetylcholine receptor antagonist scopolamine (0.125 and 0.25 microg/side) inhibited morphine-induced state-dependent memory retrieval. In addition, no significant changes were seen in memory retrieval of the animals trained before saline treatment and tested following intra-amygdala microinjection of the same doses of scopolamine (0.0625, 0.125 and 0.25 microg/side). Bilateral microinjection of scopolamine into the amygdala reversed the pilocarpine-induced potentiation of the morphine response. In view of the known actions of the drugs used, the present

  5. The influence of state dependent short range correlations on the depletion of the nuclear Fermi sea

    International Nuclear Information System (INIS)

    Lalazissis, G.A.; Massen, S.E.; Panos, C.P.

    1994-01-01

    The influence of state dependent short range correlations on the occupation numbers of the single particle shell model orbits of the doubly closed shell nuclei 16 O and 40 Ca is examined. The study shows that the effect of the state dependence of the short range correlations is rather small. The total depletion of the nuclear Fermi sea changes slightly compared with the one calculated by considering state independent short range correlations. (orig.)

  6. A Brief Review of Current Lithium Ion Battery Technology and Potential Solid State Battery Technologies

    OpenAIRE

    Ulvestad, Andrew

    2018-01-01

    Solid state battery technology has recently garnered considerable interest from companies including Toyota, BMW, Dyson, and others. The primary driver behind the commercialization of solid state batteries (SSBs) is to enable the use of lithium metal as the anode, as opposed to the currently used carbon anode, which would result in ~20% energy density improvement. However, no reported solid state battery to date meets all of the performance metrics of state of the art liquid electrolyte lithiu...

  7. Particle currents in a space-time dependent and CP-violating Higgs background: a field theory approach

    International Nuclear Information System (INIS)

    Comelli, D.; Riotto, A.

    1995-06-01

    Motivated by cosmological applications like electroweak baryogenesis, we develop a field theoretic approach to the computation of particle currents on a space-time dependent and CP-violating Higgs background. We consider the Standard Model model with two Higgs doublets and CP violation in the scalar sector, and compute both fermionic and Higgs currents by means of an expansion in the background fields. We discuss the gauge dependence of the results and the renormalization of the current operators, showing that in the limit of local equilibrium, no extra renormalization conditions are needed in order to specify the system completely. (orig.)

  8. Current state of information technology use in a US primary care practice-based research network.

    Science.gov (United States)

    Andrews, James E; Pearce, Kevin A; Sydney, Carey; Ireson, Carol; Love, Margaret

    2004-01-01

    To examine the current levels of information technology (IT) use in a primary care practice-based research network (PBRN) in order to inform future development of its infrastructure. Every primary care practitioner who is a member of the Kentucky Ambulatory Network (KAN),as well as the office managers of each practice. Practitioners included family practitioners, general practitioners, nurse practitioners and physician assistants. A cross-sectional study using two survey instruments: one for office managers and one for practitioners. The office manager survey included questions related to the current state of IT within the practice, plans for enhancement and general IT issues from the perspective of managing a practice. The practitioner survey was designed to measure current IT use and attitudes of primary care practitioners. Response rates for the surveys were 46% (n = 68) for the office managers and 51% (n = 116) for practitioners. All but one practice had internet access; however, 43% had only dial-up service. Only 21% of practitioners use an electronic medical record (EMR), with dollar cost being the barrier reported most frequently (58%). More than half of the office managers were either 'somewhat interested' (45%) or 'very interested' (17%) in a low-cost, standardised EMR that was, at the time, to be sponsored by the American Academy of Family Physicians. For practitioners, 71% were either 'somewhat' or 'very' interested in such a system. Responses to other IT issues are reported. While interest in enabling information technologies was high in KAN, adoption was variable, with use of several key technologies reported as low.The results suggest that research in this network that would be dependent on or enhanced by IT might be impeded and, generally, greater attention should be given to enhancing the IT infrastructure in primary care.

  9. Voltage and Current Regulators Design of Power Converters in Islanded Microgrids based on State Feedback Decoupling

    DEFF Research Database (Denmark)

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel

    2016-01-01

    In stand-alone microgrids based on voltage source inverters state feedback coupling between the capacitor voltage and inductor current degrades significantly the dynamics performance of voltage and current regulators. The decoupling of the controlled states is proposed, considering the limitation...... introduced by system delays. Moreover, a proportional resonant voltage controller is designed according to Nyquist criterion taking into account application requirements. Experimental tests performed in compliance with the UPS standards verify the theoretical analysis.......In stand-alone microgrids based on voltage source inverters state feedback coupling between the capacitor voltage and inductor current degrades significantly the dynamics performance of voltage and current regulators. The decoupling of the controlled states is proposed, considering the limitations...

  10. Pacemaker Dependency after Cardiac Surgery: A Systematic Review of Current Evidence.

    Science.gov (United States)

    Steyers, Curtis M; Khera, Rohan; Bhave, Prashant

    2015-01-01

    Severe postoperative conduction disturbances requiring permanent pacemaker implantation frequently occur following cardiac surgery. Little is known about the long-term pacing requirements and risk factors for pacemaker dependency in this population. We performed a systematic review of the literature addressing rates and predictors of pacemaker dependency in patients requiring permanent pacemaker implantation after cardiac surgery. Using a comprehensive search of the Medline, Web of Science and EMBASE databases, studies were selected for review based on predetermined inclusion and exclusion criteria. A total of 8 studies addressing the endpoint of pacemaker-dependency were identified, while 3 studies were found that addressed the recovery of atrioventricular (AV) conduction endpoint. There were 10 unique studies with a total of 780 patients. Mean follow-up ranged from 6-72 months. Pacemaker dependency rates ranged from 32%-91% and recovery of AV conduction ranged from 16%-42%. There was significant heterogeneity with respect to the definition of pacemaker dependency. Several patient and procedure-specific variables were found to be independently associated with pacemaker dependency, but these were not consistent between studies. Pacemaker dependency following cardiac surgery occurs with variable frequency. While individual studies have identified various perioperative risk factors for pacemaker dependency and non-resolution of AV conduction disease, results have been inconsistent. Well-conducted studies using a uniform definition of pacemaker dependency might identify patients who will benefit most from early permanent pacemaker implantation after cardiac surgery.

  11. Performance Assessment of Discontinuous Fibers in Fiber Reinforced Concrete: Current State-of-the-Art

    Science.gov (United States)

    2017-07-01

    ER D C/ G SL T R- 17 -1 9 Performance Assessment of Discontinuous Fibers in Fiber-Reinforced Concrete : Current State-of-the-Art G eo te...Discontinuous Fibers in Ultra-High Performance Fiber-Reinforced Concrete : Current State-of-the-Art Charles A. Burchfield Geotechnical and...Modeling for Force Protection” ERDC/GSL TR-17-19 ii Abstract Fiber-reinforced concretes have been developed and tested for years. During this

  12. The interplanetary magnetic field By-dependent field-aligned current in the dayside polar cap under quiet conditions

    International Nuclear Information System (INIS)

    Yamauchi, M.; Araki, T.

    1989-01-01

    Spatial distribution and temporal variation of the interplanetary magnetic field (IMF) B y -dependent cusp region field-aligned currents (FACs) during quiet periods were studied by use of magnetic data observed by Magsat. The analysis was made for 11 events (each event lasts more than one and a half days) when the IMF B y component was steadily large and B x was relatively small (|B z | y |). Results of the analysis of total 62 half-day periods for the IMF B y -dependent cusp region FAC are summarized as follows: (1) the IMF B y -dependent cusp region FAC is located at around 86 degree-87 degree invariant latitude local noon, which is more poleward than the location of the IMF B z -dependent cusp region FAC; (2) the current density of this FAC is greater than previous studies (≥ 4 μA/m 2 for IMF B y = 6 nT); (3) there are two time scales for the IMF B y -dependent cusp region FAC to appear: the initial rise of the current is on a short time scale, ∼ 10 min, and it is followed by a gradual increase on a time scale of several hours to a half day; (4) the seasonal change of this FAC is greater than that of the nightside region 1 or region 2 FACs; (5) the IMF B z -dependent cusp region FAC is not well observed around the cusp when the IMF B y -dependent cusp region FAC is intense

  13. A cyclic GMP-dependent calcium-activated chloride current in smooth-muscle cells from rat mesenteric resistance arteries

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Aalkjær, Christian; Nilsson, Holger

    2004-01-01

    M) in the pipette solution. The current was found to be a calcium-activated chloride current with an absolute requirement for cyclic GMP (EC50 6.4 microM). The current could be activated by the constitutively active subunit of PKG. Current activation was blocked by the protein kinase G antagonist Rp-8-Br......We have previously demonstrated the presence of a cyclic GMP (cGMP)-dependent calcium-activated inward current in vascular smooth-muscle cells, and suggested this to be of importance in synchronizing smooth-muscle contraction. Here we demonstrate the characteristics of this current. Using...... conventional patch-clamp technique, whole-cell currents were evoked in freshly isolated smooth-muscle cells from rat mesenteric resistance arteries by elevation of intracellular calcium with either 10 mM caffeine, 1 microM BAY K8644, 0.4 microM ionomycin, or by high calcium concentration (900 n...

  14. High-voltage, high-current, solid-state closing switch

    Energy Technology Data Exchange (ETDEWEB)

    Focia, Ronald Jeffrey

    2017-08-22

    A high-voltage, high-current, solid-state closing switch uses a field-effect transistor (e.g., a MOSFET) to trigger a high-voltage stack of thyristors. The switch can have a high hold-off voltage, high current carrying capacity, and high time-rate-of-change of current, di/dt. The fast closing switch can be used in pulsed power applications.

  15. A multiconfigurational time-dependent Hartree-Fock method for excited electronic states. I. General formalism and application to open-shell states.

    Science.gov (United States)

    Miranda, R P; Fisher, A J; Stella, L; Horsfield, A P

    2011-06-28

    The solution of the time-dependent Schrödinger equation for systems of interacting electrons is generally a prohibitive task, for which approximate methods are necessary. Popular approaches, such as the time-dependent Hartree-Fock (TDHF) approximation and time-dependent density functional theory (TDDFT), are essentially single-configurational schemes. TDHF is by construction incapable of fully accounting for the excited character of the electronic states involved in many physical processes of interest; TDDFT, although exact in principle, is limited by the currently available exchange-correlation functionals. On the other hand, multiconfigurational methods, such as the multiconfigurational time-dependent Hartree-Fock (MCTDHF) approach, provide an accurate description of the excited states and can be systematically improved. However, the computational cost becomes prohibitive as the number of degrees of freedom increases, and thus, at present, the MCTDHF method is only practical for few-electron systems. In this work, we propose an alternative approach which effectively establishes a compromise between efficiency and accuracy, by retaining the smallest possible number of configurations that catches the essential features of the electronic wavefunction. Based on a time-dependent variational principle, we derive the MCTDHF working equation for a multiconfigurational expansion with fixed coefficients and specialise to the case of general open-shell states, which are relevant for many physical processes of interest.

  16. Current distribution across type II superconducting films: a new vortex-free critical state.

    Science.gov (United States)

    Talantsev, E F; Pantoja, A E; Crump, W P; Tallon, J L

    2018-01-29

    The current distribution across the thickness of a current-carrying rectangular film in the Meissner state was established long ago by the London brothers. The distribution across the width is more complicated but was later shown to be highly non-uniform, diverging at the edges. Accordingly, the standard view for type II superconductors is that vortices enter at the edges and, with increasing current, are driven inwards until they self-annihilate at the centre, causing dissipation. This condition is presumed to define the critical current. However we have shown that, under self-field (no external field), the transport critical current is a London surface current where the surface current density equals the critical field divided by λ, across the entire width. The critical current distribution must therefore be uniform. Here we report studies of the current and field distribution across commercial YBa 2 Cu 3 O 7 conductors and confirm the accepted non-uniform distribution at low current but demonstrate a radical crossover to a uniform distribution at critical current. This crossover ends discontinuously at a singularity and calculations quantitatively confirm these results in detail. The onset of self-field dissipation is, unexpectedly, thermodynamic in character and the implied vortex-free critical state seems to require new physics.

  17. Light Effects on Behavioural Performance Depend on the Individual State of Vigilance

    Science.gov (United States)

    Barba, Antonio; Padilla, Francisca

    2016-01-01

    Research has shown that exposure to bright white light or blue-enriched light enhances alertness, but this effect is not consistently observed in tasks demanding high-level cognition (e.g., Sustained Attention to Response Task—SART, which measures inhibitory control). Individual differences in sensitivity to light effects might be mediated by variations in the basal level of arousal. We tested this hypothesis by measuring the participants’ behavioural state of vigilance before light exposure, through the Psychomotor Vigilance Task. Then we compared the effects of a blue-enriched vs. dim light at nighttime on the performance of the auditory SART, by controlling for individual differences in basal arousal. The results replicated the alerting effects of blue-enriched light, as indexed by lower values of both proximal temperature and distal-proximal gradient. The main finding was that lighting effects on SART performance were highly variable across individuals and depended on their prior state of vigilance. Specifically, participants with higher levels of basal vigilance before light exposure benefited most from blue-enriched lighting, responding faster in the SART. These results highlight the importance of considering basal vigilance to define the boundary conditions of light effects on cognitive performance. Our study adds to current research delineating the complex and reciprocal interactions between lighting effects, arousal, cognitive task demands and behavioural performance. PMID:27820822

  18. The effect of a musical mood induction procedure on mood state-dependent word retrieval.

    Science.gov (United States)

    De L'Etoile, Shannon K

    2002-01-01

    The purpose of this experiment was to replicate and expand upon an earlier study by Thaut and de l'Etoile (1993) by examining the effect of a musical mood induction procedure on mood state-dependent word retrieval. Participants (N = 45) completed a 2-day testing procedure. On day one, participants read a list of adjectives and wrote down an antonym for each one. On day two, participants recalled as many of the antonyms as possible. During the testing procedure, participants were placed in 1 of 4 conditions: (a) mood induction at encoding, (b) mood induction at recall, (c) no mood induction, and (d) mood induction at both encoding and recall. The mood induction procedure included 3 steps. Participants first assessed their current mood state using a visual analog scale. They then listened to music for 5 minutes, determined the mood of the piece while listening, and tried to match their mood to the music. Finally, participants again used the visual analog scale to indicate their mood. Results indicated that participants who received mood induction prior to both encoding and recall were able to retrieve significantly more words than participants who did not undergo any mood induction. The results are discussed in light of the associative network theory of memory and emotions and the treatment of mood disorders.

  19. Assessment of Energy Production Potential from Ocean Currents along the United States Coastline

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Kevin A. [Georgia Inst. of Technology, Atlanta, GA (United States)

    2013-10-03

    Increasing energy consumption and depleting reserves of fossil fuels have resulted in growing interest in alternative renewable energy from the ocean. Ocean currents are an alternative source of clean energy due to their inherent reliability, persistence and sustainability. General ocean circulations exist in the form of large rotating ocean gyres, and feature extremely rapid current flow in the western boundaries due to the Coriolis Effect. The Gulf Stream system is formed by the western boundary current of the North Atlantic Ocean that flows along the east coastline of the United States, and therefore is of particular interest as a potential energy resource for the United States.

  20. Binding of benzocaine in batrachotoxin-modified Na+ channels. State-dependent interactions.

    Science.gov (United States)

    Wang, G K; Wang, S Y

    1994-03-01

    Hille (1977. Journal of General Physiology. 69:497-515) first proposed a modulated receptor hypothesis (MRH) to explain the action of benzocaine in voltage-gated Na+ channels. Using the MRH as a framework, we examined benzocaine binding in batrachotoxin (BTX)-modified Na+ channels under voltage-clamp conditions using either step or ramp command signals. We found that benzocaine binding is strongly voltage dependent. At -70 mV, the concentration of benzocaine that inhibits 50% of BTX-modified Na+ currents in GH3 cells (IC50) is 0.2 mM, whereas at +50 mV, the IC50 is 1.3 mM. Dose-response curves indicate that only one molecule of benzocaine is required to bind with one BTX-modified Na+ channel at -70 mV, whereas approximately two molecules are needed at +50 mV. Upon treatment with the inactivation modifier chloramine-T, the binding affinity of benzocaine is reduced significantly at -70 mV, probably as a result of the removal of the inactivated state of BTX-modified Na+ channels. The same treatment, however, enhances the binding affinity of cocaine near this voltage. External Na+ ions appear to have little effect on benzocaine binding, although they do affect cocaine binding. We conclude that two mechanisms underlie the action of local anesthetics in BTX-modified Na+ channels. Unlike open-channel blockers such as cocaine and bupivacaine, neutral benzocaine binds preferentially with BTX-modified Na+ channels in a closed state. Furthermore, benzocaine can be modified chemically so that it behaves like an open-channel blocker. This compound also elicits a use-dependent block in unmodified Na+ channels after repetitive depolarizations, whereas benzocaine does not. The implications of these findings for the MRH theory will be discussed.

  1. Local Properties of Solutions to Non-Autonomous Parabolic PDEs with State-Dependent Delays

    Czech Academy of Sciences Publication Activity Database

    Rezunenko, Oleksandr

    2012-01-01

    Roč. 2, č. 2 (2012), s. 56-71 ISSN 2158-611X R&D Projects: GA ČR(CZ) GAP103/12/2431 Institutional support: RVO:67985556 Keywords : partial differential equations * state-dependent delay * invariance principle Subject RIV: BC - Control Systems Theory http://library.utia.cas.cz/separaty/2012/AS/rezunenko- local properties of solutions to non-autonomous parabolic PDEs with state-dependent delay s.pdf

  2. State-dependent resource harvesting with lagged information about system states

    Science.gov (United States)

    Johnson, Fred A.; Fackler, Paul L.; Boomer, G Scott; Zimmerman, Guthrie S.; Williams, Byron K.; Nichols, James D.; Dorazio, Robert

    2016-01-01

    Markov decision processes (MDPs), which involve a temporal sequence of actions conditioned on the state of the managed system, are increasingly being applied in natural resource management. This study focuses on the modification of a traditional MDP to account for those cases in which an action must be chosen after a significant time lag in observing system state, but just prior to a new observation. In order to calculate an optimal decision policy under these conditions, possible actions must be conditioned on the previous observed system state and action taken. We show how to solve these problems when the state transition structure is known and when it is uncertain. Our focus is on the latter case, and we show how actions must be conditioned not only on the previous system state and action, but on the probabilities associated with alternative models of system dynamics. To demonstrate this framework, we calculated and simulated optimal, adaptive policies for MDPs with lagged states for the problem of deciding annual harvest regulations for mallards (Anas platyrhynchos) in the United States. In this particular example, changes in harvest policy induced by the use of lagged information about system state were sufficient to maintain expected management performance (e.g. population size, harvest) even in the face of an uncertain system state at the time of a decision.

  3. State-Dependent Resource Harvesting with Lagged Information about System States.

    Directory of Open Access Journals (Sweden)

    Fred A Johnson

    Full Text Available Markov decision processes (MDPs, which involve a temporal sequence of actions conditioned on the state of the managed system, are increasingly being applied in natural resource management. This study focuses on the modification of a traditional MDP to account for those cases in which an action must be chosen after a significant time lag in observing system state, but just prior to a new observation. In order to calculate an optimal decision policy under these conditions, possible actions must be conditioned on the previous observed system state and action taken. We show how to solve these problems when the state transition structure is known and when it is uncertain. Our focus is on the latter case, and we show how actions must be conditioned not only on the previous system state and action, but on the probabilities associated with alternative models of system dynamics. To demonstrate this framework, we calculated and simulated optimal, adaptive policies for MDPs with lagged states for the problem of deciding annual harvest regulations for mallards (Anas platyrhynchos in the United States. In this particular example, changes in harvest policy induced by the use of lagged information about system state were sufficient to maintain expected management performance (e.g. population size, harvest even in the face of an uncertain system state at the time of a decision.

  4. State-Dependence of the Climate Sensitivity in Earth System Models of Intermediate Complexity

    Science.gov (United States)

    Pfister, Patrik L.; Stocker, Thomas F.

    2017-10-01

    Growing evidence from general circulation models (GCMs) indicates that the equilibrium climate sensitivity (ECS) depends on the magnitude of forcing, which is commonly referred to as state-dependence. We present a comprehensive assessment of ECS state-dependence in Earth system models of intermediate complexity (EMICs) by analyzing millennial simulations with sustained 2×CO2 and 4×CO2 forcings. We compare different extrapolation methods and show that ECS is smaller in the higher-forcing scenario in 12 out of 15 EMICs, in contrast to the opposite behavior reported from GCMs. In one such EMIC, the Bern3D-LPX model, this state-dependence is mainly due to the weakening sea ice-albedo feedback in the Southern Ocean, which depends on model configuration. Due to ocean-mixing adjustments, state-dependence is only detected hundreds of years after the abrupt forcing, highlighting the need for long model integrations. Adjustments to feedback parametrizations of EMICs may be necessary if GCM intercomparisons confirm an opposite state-dependence.

  5. Temperature dependence of the kinetic coefficients of superconductors in the intermediate state

    International Nuclear Information System (INIS)

    Gorelik, L.Y.; Kadigrobov, A.M.

    1981-01-01

    It is demonstrated that in the case of a superconductor in the intermediate state at temperature T such that e0/T 0 denoting the characteristic superconductor energy gap) the sound absorption coefficient can be strongly temperature dependent and thermal conductivity along the layers of normal metal can be nonlinearly dependent on the temperature

  6. Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent.

    Science.gov (United States)

    McCool, Brian A; Chappell, Ann

    2007-03-12

    Strychnine-sensitive glycine receptors are expressed in many adult forebrain regions, yet the biological function of these receptors outside the spinal cord/brainstem is poorly understood. We have recently shown that rat lateral/basolateral amygdala neurons express strychnine-sensitive glycine-gated currents whose pharmacological and molecular characteristics are consistent with those established for classic ligand-gated chloride channels. The current studies were undertaken to establish the behavioral role, if any, of these strychnine-sensitive glycine receptors. Adult Long-Evans male rats were implanted with guide cannulae targeted at the lateral amygdala and were microinjected with standard artificial cerebrospinal fluid with or without various doses of strychnine or taurine. Anxiety-like behaviors were assessed with the elevated plus maze or the light/dark box. In the elevated plus maze, strychnine decreased closed-arm time and increased open-arm time, suggestive of an anxiolytic effect. Similarly, strychnine produced a modest anxiolytic effect in the light/dark box. Post hoc analysis of 'open-arm' time and 'light-side' time indicated that aCSF-treated animals were distributed into two apparent groups that displayed either high or low amounts of anxiety-like behavior in a given apparatus. Surprisingly, the pharmacological effects of both strychnine and taurine in these assays were dependent upon a given animal's behavioral phenotype. Together, these findings are significant because they suggest that the basal 'emotional state' of the animal could influence the behavioral outcome associated with drug application directly into the lateral/basolateral amygdala. Furthermore, our findings also suggest that compounds acting at amygdala strychnine-sensitive glycine receptors may actively modulate this basal anxiety-like state.

  7. State of the art of cattle dehorning in the EU Member States. A quantitative survey of the current practices

    NARCIS (Netherlands)

    Cozzi, G.; Gottardo, F.; Brscic, M.; Contiero, B.; Irrgang, N.; Knierim, U.; Pentelescu, O.; Windig, J.J.; Mirabito, L.; Kling Eveillard, F.; Dockes, A.C.; Veissier, I.; Velarde, A.; Fuentes, C.; Dalmau, A.; Winckler, C.

    2015-01-01

    A survey was carried out to describe the extent and current practice of cattle disbudding/dehorning in the EU Member States. Disbudding was defined as removal of horns in calves of up to 2 months of age, whereas dehorning was defined as removal of horns in older animals. Specific questionnaires were

  8. Dynamic current susceptibility as a probe of Majorana bound states in nanowire-based Josephson junctions

    Science.gov (United States)

    Trif, Mircea; Dmytruk, Olesia; Bouchiat, Hélène; Aguado, Ramón; Simon, Pascal

    2018-02-01

    We theoretically study a Josephson junction based on a semiconducting nanowire subject to a time-dependent flux bias. We establish a general density-matrix approach for the dynamical response of the Majorana junction and calculate the resulting flux-dependent susceptibility using both microscopic and effective low-energy descriptions for the nanowire. We find that the diagonal component of the susceptibility, associated with the dynamics of the Majorana state populations, dominates over the standard Kubo contribution for a wide range of experimentally relevant parameters. The diagonal term, explored, in this Rapid Communication, in the context of Majorana physics, allows probing accurately the presence of Majorana bound states in the junction.

  9. Magnetic Field Dependence of the Critical Current in S-N Bilayer Thin Films

    Science.gov (United States)

    Sadleir, John E.; Lee, Sang-Jun; Smith, Stephen James; Bandler, Simon; Chervenak, James; Kilbourne, Caroline A.; Finkbeiner, Fred M.; Porter, Frederick S.; Kelley, Richard L.; Adams, Joseph S.; hide

    2013-01-01

    Here we investigate the effects a non-uniform applied magnetic field has on superconducting transition-edge sensors (TESs) critical current. This has implications on TES optimization. It has been shown that TESs resistive transition can be altered by magnetic fields. We have observed critical current rectification effects and explained these effects in terms of a magnetic self-field arising from asymmetric current injection into the sensor. Our TES physical model shows that this magnetic self-field can result in significantly degraded or improved TES performance. In order for this magnetically tuned TES strategy to reach its full potential we are investigating the effect a non-uniform applied magnetic field has on the critical current.

  10. Research on State-of-Charge (SOC) estimation using current integration based on temperature compensation

    Science.gov (United States)

    Yin, J.; Shen, Y.; Liu, X. T.; Zeng, G. J.; Liu, D. C.

    2017-11-01

    The traditional current integral method for the state-of-charge (SOC) estimation has an unusable estimation accuracy because of the current measuring error. This paper proposed a closed-loop temperature compensation method to improve the SOC estimation accuracy of current integral method by eliminating temperature drift. Through circuit simulation result in Multisim, the stability of current measuring accuracy is improved by more than 10 times. In a designed 70 charge-discharge experimental circle, the SOC estimation error with temperature compensation had 30 times less than error in normal situation without compensation.

  11. Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions

    Directory of Open Access Journals (Sweden)

    Saliba AN

    2015-06-01

    Full Text Available Antoine N Saliba, Afif R Harb, Ali T Taher Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut, Beirut, Lebanon Abstract: Transfusional iron overload is a major target in the care of patients with transfusion-dependent thalassemia (TDT and other refractory anemias. Iron accumulates in the liver, heart, and endocrine organs leading to a wide array of complications. In this review, we summarize the characteristics of the approved iron chelators, deferoxamine, deferiprone, and deferasirox, and the evidence behind the use of each, as monotherapy or as part of combination therapy. We also review the different guidelines on iron chelation in TDT. This review also discusses future prospects and directions in the treatment of transfusional iron overload in TDT whether through innovation in chelation or other therapies, such as novel agents that improve transfusion dependence. Keywords: thalassemia, transfusion-dependent thalassemia, iron overload, iron chelation therapy, transfusion

  12. Temperature dependent capacity contribution of thermally treated anode current collectors in lithium ion batteries

    International Nuclear Information System (INIS)

    Kim, Tae Kwon; Li Xifei; Wang Chunlei

    2013-01-01

    Highlights: ► We studied the influence of the thermal treatment of current collectors on the energy capacity. ► Different current collectors show different thermal treatment effect on performance. ► The non-negligible capacity contribution is closely related to the treatment temperatures. ► Our results could be beneficial to designing battery architectures. - Abstract: Metal current collectors, offering a good connection between the active materials and the external circuit, is an important component in a rechargeable lithium ion battery. Some necessary thermal treatment in the battery fabrication and assembly procedure results in current collectors with some non-negligible reversible energy capacities; however, these energy capacities were negligible in the previous references. In this research, for the first time, we investigated the influence of the thermal treatment of current collectors (such as copper foil and stainless steel disk) on energy capacities. Our results indicate that different current collector materials have different thermal treatment effects on their electrochemical performance. The non-negligible capacity contribution is closely related to the treatment temperature.

  13. Little rip cosmological models with quadratic equation of state with time dependent parameters

    Science.gov (United States)

    Shelote, R. D.; Khadekar, G. S.

    2018-02-01

    We have studied flat FRW cosmological model of the universe filled with an ideal fluid with quadratic equation of state (EOS) with time dependent parameters ω(t) and Λ(t). We found the equation of the state parameter ω(t) is less than -1 and also found Little Rip (LR) and Pseudo Rip (PR) behavior for dark energy.

  14. State-dependent self-representations: a culture-bound aspect of identity.

    Science.gov (United States)

    Ghorpade, Amar

    2009-03-01

    The concepts of identity, self and self-representation have been discussed extensively in psychoanalytic metapsychology. These concepts are at times confusing and are used interchangeably by various authors. Regardless of what one calls it, what one experiences in a given moment is one's representation as an analyst or a father or a son or daughter, depending on the situation one is in. This paper describes such state-dependent self-representations as an aspect of the self and argues that state-dependent self-representations are probably more clinically relevant and useful in day-to-day practice.

  15. Current and Future Potential Risk of Establishment of Grapholita molesta (Lepidoptera: Tortricidae) in Washington State.

    Science.gov (United States)

    Neven, Lisa G; Kumar, Sunil; Yee, Wee L; Wakie, Tewodros

    2018-02-17

    The oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae), is a primary pest of stone fruits that cause significant economic damage. Larvae, which enter the host plant through shoot tips, damage shoots, and ripe fruits. Native to Asia, this pest now occurs in many fruit-growing countries, including the United States and Canada. Though the pest was previously reported from many states within the United States, its current distribution and the environmental variables that influence its distribution are not properly identified. The objectives of this study were to 1) identify the environmental factors associated with G. molesta current distribution, 2) predict the current distribution of G. molesta in Washington State (WA) using Maxent and Climex models, 3) identify those areas within WA best suited for establishment of pest free zones, areas of low pest prevalence, and pest free production areas, and 4) identify regions most at risk for further expansion of G. molesta populations as a function of climate change. The current models predicted a small portion of central WA is suitable to support G. molesta, which is consistent with observed distributions. However, climate change models predict that more areas will become suitable for the pest. These results indicate that action should be taken to monitor and reduce current populations of G. molesta to stem its potential expansion into the major commercial tree fruit production areas in the state.

  16. Multiple states and hysteresis in a two-layer loop current type system

    Science.gov (United States)

    Kuehl, J.; Sheremet, V.

    2017-12-01

    Rotating table experiments are considered of a two-layer loop current type or gap-leaping system. Such experiments are representative of oceanic regions including the Kuroshio current crossing the Luzon Strait, the Gulf of Mexico Loop Current, the Northeast Chanel of the Gulf of Maine where Scotian shelf water leaps directly from Browns bank to Georges Bank and more. Systems such as these are known to admit two dominant states: leaping across the gap or penetrating into the gap forming a loop current. Which state the system will assume and when transitions between states will occur are open problems. We show that such systems admit multiple steady states with hysteresis when the strength of the current is varied. When the state of the system is viewed in a parameter space representing inertia and vorticity constraint, the system is found to be characterized by a cusp topology of solutions. The existence of such dynamics in two-layer quasi-geostrophic systems has significant implications for oceanographic predictability.

  17. Stress state dependence of transient irradiation creep in 20% cold worked 316 stainless steel

    International Nuclear Information System (INIS)

    Foster, J.P.; Gilbert, E.R.

    1998-01-01

    Irradiation creep tests were performed in fast reactors using the stress states of uniaxial tension, biaxial tension, bending and torsion. In order to compare the saturated transient strain irradiation creep component, the test data were converted to equivalent strain and equivalent stress. The saturated transient irradiation creep component was observed to depend on the stress state. The highest value was exhibited by the uniaxial tension stress state, and the lowest by the torsion stress state. The biaxial tension and bending stress state transient component values were intermediate. This behavior appears to be related to the dislocation or microscopic substructure resulting from fabrication processing and the applied stress direction. (orig.)

  18. Integrated and Inclusive Higher Education in Vladimir State University: Current State and Development Perspectives

    Directory of Open Access Journals (Sweden)

    Yegorov I.N.,

    2017-08-01

    Full Text Available The paper summarizes the many years of experience in methodological support and training at the Center of Professional Education for the Disabled and at the “Inclusive Education” Research and Educational Center of the Vladimir State University. At these centers the work is aimed at establishing a system of continuous higher inclusive education for persons with hearing and visual impairments. The paper focuses on the issues concerning the organization of educational process and the adaptation of learning materials for students with hearing and visual impairments; it addresses the problem of creating a system of academic support for students with disabilities and providing psychological and educational assistance to individuals with hearing and visual impairments in the system of higher education.

  19. The role of relativity in the optical response of gold within the time-dependent current-density-functional theory

    NARCIS (Netherlands)

    Romaniello, P; de Boeij, PL

    2005-01-01

    We included relativistic effects in the formulation of the time-dependent current-density-functional theory for the calculation of linear response properties of metals [P. Romaniello and P. L. de Boeij, Phys. Rev. B (to be published)]. We treat the dominant scalar-relativistic effects using the

  20. On the construction of coherent states of position dependent mass Schroedinger equation endowed with effective potential

    International Nuclear Information System (INIS)

    Chithiika Ruby, V.; Senthilvelan, M.

    2010-01-01

    In this paper, we propose an algorithm to construct coherent states for an exactly solvable position dependent mass Schroedinger equation. We use point canonical transformation method and obtain ground state eigenfunction of the position dependent mass Schroedinger equation. We fix the ladder operators in the deformed form and obtain explicit expression of the deformed superpotential in terms of mass distribution and its derivative. We also prove that these deformed operators lead to minimum uncertainty relations. Further, we illustrate our algorithm with two examples, in which the coherent states given for the second example are new.

  1. From State Dependent Diffusion to Constant Diffusion in Stochastic Differential Equations by the Lamperti Transform

    DEFF Research Database (Denmark)

    Møller, Jan Kloppenborg; Madsen, Henrik

    This report describes methods to eliminate state dependent diffusion terms in Stochastic Differential Equations (SDEs). Transformations that leave the diffusion term of SDEs constant is important for simulation, and estimation. It is important for simulation because the Euler approximation...... convergence rate is faster, and for estimation because the Extended Kalman Filter equations are easier to implement than higher order filters needed in the case of state dependent diffusion terms. The general class of transformations which leaves the diffusion term independent of the state is called...

  2. Numerical Studies of Friction Between Metallic Surfaces and of its Dependence on Electric Currents

    Science.gov (United States)

    Meintanis, Evangelos; Marder, Michael

    2009-03-01

    We will present molecular dynamics simulations that explore the frictional mechanisms between clean metallic surfaces. We employ the HOLA molecular dynamics code to run slider-on-block experiments. Both objects are allowed to evolve freely. We recover realistic coefficients of friction and verify the importance of cold-welding and plastic deformations in dry sliding friction. We also find that plastic deformations can significantly affect both objects, despite a difference in hardness. Metallic contacts have significant technological applications in the transmission of electric currents. To explore the effects of the latter to sliding, we had to integrate an electrodynamics solver into the molecular dynamics code. The disparate time scales involved posed a challenge, but we have developed an efficient scheme for such an integration. A limited electrodynamic solver has been implemented and we are currently exploring the effects of currents in the friction and wear of metallic contacts.

  3. Brain state-dependence of electrically evoked potentials monitored with head-mounted electronics.

    Science.gov (United States)

    Richardson, Andrew G; Fetz, Eberhard E

    2012-11-01

    Inferring changes in brain connectivity is critical to studies of learning-related plasticity and stimulus-induced conditioning of neural circuits. In addition, monitoring spontaneous fluctuations in connectivity can provide insight into information processing during different brain states. Here, we quantified state-dependent connectivity changes throughout the 24-h sleep-wake cycle in freely behaving monkeys. A novel, head-mounted electronic device was used to electrically stimulate at one site and record evoked potentials at other sites. Electrically evoked potentials (EEPs) revealed the connectivity pattern between several cortical sites and the basal forebrain. We quantified state-dependent changes in the EEPs. Cortico-cortical EEP amplitude increased during slow-wave sleep, compared to wakefulness, while basal-cortical EEP amplitude decreased. The results demonstrate the utility of using portable electronics to document state-dependent connectivity changes in freely behaving primates.

  4. Effect of state-dependent delay on a weakly damped nonlinear oscillator.

    Science.gov (United States)

    Mitchell, Jonathan L; Carr, Thomas W

    2011-04-01

    We consider a weakly damped nonlinear oscillator with state-dependent delay, which has applications in models for lasers, epidemics, and microparasites. More generally, the delay-differential equations considered are a predator-prey system where the delayed term is linear and represents the proliferation of the predator. We determine the critical value of the delay that causes the steady state to become unstable to periodic oscillations via a Hopf bifurcation. Using asymptotic averaging, we determine how the system's behavior is influenced by the functional form of the state-dependent delay. Specifically, we determine whether the branch of periodic solutions will be either sub- or supercritical as well as an accurate estimation of the amplitude. Finally, we choose a few examples of state-dependent delay to test our analytical results by comparing them to numerical continuation.

  5. Exploration is dependent on reproductive state, not social state, in a cooperatively breeding bird

    NARCIS (Netherlands)

    Edwards, Hannah A.; Dugdale, Hannah L.; Richardson, David S.; Komdeur, Jan; Burke, Terry

    2016-01-01

    Personality is an intriguing phenomenon in populations because it constrains behavioral flexibility. One theory suggests that personality could be generated and maintained if dependent on asset protection. It is predicted that trade-offs with fitness expectations and survival probability encourage

  6. Dependence of CIT [Compact Ignition Tokamak] PF [poloidal field] coil currents on profile and shape parameters using the Control Matrix

    International Nuclear Information System (INIS)

    Strickler, D.J.; Peng, Y-K.M.; Jardin, S.C.; Pomphrey, N.

    1990-01-01

    The plasma shaping flexibility of the Compact Ignition Tokamak (CIT) poloidal field (PF) coil set is demonstrated through MHD equilibrium calculations of optimal PF coil current distributions and their variation with poloidal beta, internal inductance, plasma 95% elongation, and 95% triangularity. Calculations of the magnetic stored energy are used to compare solutions associated with various plasma parameters. The Control Matrix (CM) equilibrium code, together with the nonlinear equation and numerical optimization software packages HYBRD, and VMCON, respectively, are used to find equilibrium coil current distributions for fixed divertor geometry, volt-seconds, and plasma profiles in order to isolate the dependence on individual parameters. A reference equilibrium and coil current distribution are chosen, and correction currents dI are determined using the CM equilibrium method to obtain other specified plasma shapes. The reference equilibrium is the κ = 2 divertor at beginning of flattop (BOFT) with a minimum stored energy solution for the coil current distribution. The pressure profile function is fixed

  7. Model of canonical profiles for time-dependent problems with variation of the total current

    International Nuclear Information System (INIS)

    Dnestrovskii, Yu.D.; Lysenko, S.E.

    1992-01-01

    The regimes in which the current varies in TFTR, JET, and ASDEX are analyzed. It is shown that the principle of profile consistency holds at the periphery of the plasma column, and the shape of the canonical profile is determined by the value of the safety factor q in the gradient region. A modified transport model is developed for the canonical profiles, which allows the time lag of the energy content of the plasma with relative to the current variation to be explained reasonably. 9 refs., 8 figs

  8. NO involvement in the inhibition of ghrelin on voltage-dependent potassium currents in rat hippocampal cells.

    Science.gov (United States)

    Lu, Yong; Dang, Shaokang; Wang, Xu; Zhang, Junli; Zhang, Lin; Su, Qian; Zhang, Huiping; Lin, Tianwei; Zhang, Xiaoxiao; Zhang, Yurong; Sun, Hongli; Zhu, Zhongliang; Li, Hui

    2018-01-01

    Ghrelin is a peptide hormone that plays an important role in promoting appetite, regulating distribution and rate of use of energy, cognition, and mood disorders, but the relevant neural mechanisms of these function are still not clear. In this study, we examined the effect of ghrelin on voltage-dependent potassium (K + ) currents in hippocampal cells of 1-3 days SD rats by whole-cell patch-clamp technique, and discussed whether NO was involved in this process. The results showed that ghrelin significantly inhibited the voltage-dependent K + currents in hippocampal cells, and the inhibitory effect was more significant when l-arginine was co-administered. In contrast, N-nitro- l-arginine methyl ester increased the ghrelin inhibited K + currents and attenuated the inhibitory effect of ghrelin. While d-arginine (D-AA) showed no significant impact on the ghrelin-induced decrease in K + current. These results show that ghrelin may play a physiological role by inhibiting hippocampal voltage dependent K + currents, and the NO pathway may be involved in this process. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.

    Directory of Open Access Journals (Sweden)

    Teemu Aitta-aho

    Full Text Available In state-dependency, information retrieval is most efficient when the animal is in the same state as it was during the information acquisition. State-dependency has been implicated in a variety of learning and memory processes, but its mechanisms remain to be resolved. Here, mice deficient in AMPA-type glutamate receptor GluA1 subunits were first conditioned to morphine (10 or 20 mg/kg s.c. during eight sessions over four days using an unbiased procedure, followed by testing for conditioned place preference at morphine states that were the same as or different from the one the mice were conditioned to. In GluA1 wildtype littermate mice the same-state morphine dose produced the greatest expression of place preference, while in the knockout mice no place preference was then detected. Both wildtype and knockout mice expressed moderate morphine-induced place preference when not at the morphine state (saline treatment at the test; in this case, place preference was weaker than that in the same-state test in wildtype mice. No correlation between place preference scores and locomotor activity during testing was found. Additionally, as compared to the controls, the knockout mice showed unchanged sensitization to morphine, morphine drug discrimination and brain regional μ-opioid receptor signal transduction at the G-protein level. However, the knockout mice failed to show increased AMPA/NMDA receptor current ratios in the ventral tegmental area dopamine neurons of midbrain slices after a single injection of morphine (10 mg/kg, s.c., sliced prepared 24 h afterwards, in contrast to the wildtype mice. The results indicate impaired drug-induced state-dependency in GluA1 knockout mice, correlating with impaired opioid-induced glutamate receptor neuroplasticity.

  10. Including Alternative Resources in State Renewable Portfolio Standards: Current Design and Implementation Experience

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Bird, L.

    2012-11-01

    Currently, 29 states, the District of Columbia, and Puerto Rico have instituted a renewable portfolio standard (RPS). An RPS sets a minimum threshold for how much renewable energy must be generated in a given year. Each state policy is unique, varying in percentage targets, timetables, and eligible resources. This paper examines state experience with implementing renewable portfolio standards that include energy efficiency, thermal resources, and non-renewable energy and explores compliance experience, costs, and how states evaluate, measure, and verify energy efficiency and convert thermal energy. It aims to gain insights from the experience of states for possible federal clean energy policy as well as to share experience and lessons for state RPS implementation.

  11. Death and dependence: current controversies over the selective serotonin reuptake inhibitors.

    Science.gov (United States)

    Nutt, David J

    2003-12-01

    Recent years have seen a considerable media interest in the adverse effects of the selective serotonin reuptake inhibitors (SSRIs). This has led to claims that these antidepressants may lead to suicide and homicide and that they cause dependence or even addiction. Such claims have caused great concerns to many patients and have confused doctors in both primary care and psychiatric practice. In this article I review the basis of these claims and show that many seem to emerge from the misinterpretation of evidence and the use of imprecise definitions. Although the SSRIs are not free of problems they compare very favourably with other antidepressants and other classes of psychotropic drugs. There is no evidence they are addictive in the formal sense of leading to a drug dependence syndrome. Some suggestions on the way these issues can be more precisely defined and studied in future are given.

  12. Depending on the Kindness of Strangers: Current National Data Initiatives and Developmental Research.

    Science.gov (United States)

    Brooks-Gunn, Jeanne; Berlin, Lisa J.; Leventhal, Tama; Fuligni, Allison Sidle

    2000-01-01

    Reviews current large-scale, longitudinal studies focusing on children. Describes the data collected, including child outcomes, process-oriented information on child-parent interactions, child care quality, parental mental health, family violence, fathering, employment patterns, and community characteristics. Notes that several studies incorporate…

  13. Responsivity Dependent Anodization Current Density of Nanoporous Silicon Based MSM Photodetector

    Directory of Open Access Journals (Sweden)

    Batool Eneaze B. Al-Jumaili

    2016-01-01

    Full Text Available Achieving a cheap and ultrafast metal-semiconductor-metal (MSM photodetector (PD for very high-speed communications is ever-demanding. We report the influence of anodization current density variation on the response of nanoporous silicon (NPSi based MSM PD with platinum (Pt contact electrodes. Such NPSi samples are grown from n-type Si (100 wafer using photoelectrochemical etching with three different anodization current densities. FESEM images of as-prepared samples revealed the existence of discrete pores with spherical and square-like shapes. XRD pattern displayed the growth of nanocrystals with (311 lattice orientation. The nanocrystallite sizes obtained using Scherrer formula are found to be between 20.8 nm and 28.6 nm. The observed rectifying behavior in the I-V characteristics is ascribed to the Pt/PSi/n-Si Schottky barrier formation, where the barrier height at the Pt/PSi interface is estimated to be 0.69 eV. Furthermore, this Pt/PSi/Pt MSM PD achieved maximum responsivity of 0.17 A/W and quantum efficiency as much as 39.3%. The photoresponse of this NPSi based MSM PD demonstrated excellent repeatability, fast response, and enhanced saturation current with increasing anodization current density.

  14. Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin

    DEFF Research Database (Denmark)

    Fuchs, W; Larsen, Erik Hviid; Lindemann, B

    1977-01-01

    1. The inward facing membranes of in vitro frog skin epithelium were depolarized with solutions of high K concentration. The electrical properties of the epithelium are then expected to be governed by the outward facing, Na-selective membrane.2. In this state, the transepithelial voltage (V) was ...

  15. High magnetic field science and its application in the United States current status and future directions

    CERN Document Server

    National Research Council of the National Academies

    2013-01-01

    The Committee to Assess the Current Status and Future Direction of High Magnetic Field Science in the United States was convened by the National Research Council in response to a request by the National Science Foundation. This report answers three questions: (1) What is the current state of high-field magnet science, engineering, and technology in the United States, and are there any conspicuous needs to be addressed? (2) What are the current science drivers and which scientific opportunities and challenges can be anticipated over the next ten years? (3) What are the principal existing and planned high magnetic field facilities outside of the United States, what roles have U.S. high field magnet development efforts played in developing those facilities, and what potentials exist for further international collaboration in this area? A magnetic field is produced by an electrical current in a metal coil. This current exerts an expansive force on the coil, and a magnetic field is "high" if it challenges the str...

  16. What is the current state of scientific knowledge with regard to seasonal and decadal forecasting?

    International Nuclear Information System (INIS)

    Smith, Doug M; Scaife, Adam A; Kirtman, Ben P

    2012-01-01

    Environmental factors, such as the frequency, intensity and duration of extreme weather events, are important drivers of migration and displacement of people. There is therefore a growing need for regional climate predictions for the coming seasons to decades. This paper reviews the current state of the art of seasonal to decadal climate prediction, focusing on the potential sources of skill, forecasting techniques, current capability and future prospects. (letter)

  17. A New Authorization for Use of Military Force Against the Islamic State: Issues and Current Proposals

    Science.gov (United States)

    2016-01-15

    A New Authorization for Use of Military Force Against the Islamic State: Issues and Current Proposals Matthew C. Weed Specialist in Foreign...Policy Legislation January 15, 2016 Congressional Research Service 7-5700 www.crs.gov R43760 A New Authorization for Use of Military Force...about the President’s authority to use military force against the Islamic State. Some efforts began near the end of the 113 th Congress to consider

  18. Multiple dual mode counter-current chromatography with periodic sample injection: Steady-state and non-steady-state operation.

    Science.gov (United States)

    Kostanyan, Artak E

    2014-12-19

    The multiple dual mode (MDM) counter-current chromatography (CCC) separation consists of a succession of two isocratic counter-current steps and is carried out in series alternating between normal phase and reversed phase operation. The performance of the MDM technique can be improved by the sample re-injection between each of the dual-mode steps. The objective of this work was to develop analytical expressions to describe the MDM CCC with periodic sample injection, which can be used to simulate these processes and select optimal operating conditions for the separation of a given feed mixture. Two possible methods of the MDM separation with periodic sample injection are considered: 1 - steady-state separation: the duration of the flow periods of the phases is kept constant for all the cycles and the steady-state regime is achieved after a certain number of cycles. 2 - non-steady-state separation with variable duration of phase elution steps. It is shown that proper selection of the duration of phase flow times allows to reach complete separation of solutes in continuous steady-state operation mode even in a low efficiency column. This mode of operation provides both high productivity and high resolution. The non-steady-state method with variable duration of phase elution steps offers several options to split a mixture into groups of compounds and/or concentrate target compounds. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Vortex domain structures and dc current dependence of magneto-resistances in magnetic tunnel junctions

    Science.gov (United States)

    Wei, Hong-Xiang; Lu, Qing-Feng; Zhao, Su-Fen; Zhang, Xie-Qun; Feng, Jia-Feng; Han, Xiu-Feng

    2004-09-01

    Microfabrication and the magneto-transport characteristics of the magnetic tunnel junctions (MTJs) with a spin-valve-type structure of Ta (5nm)/Ni79Fe21 (25nm)/Ir22Mn78 (12nm)/Co75Fe25 (4nm)/Al(0.8nm) oxide/Co75Fe25 (4nm)/Ni79Fe21 (20nm)/Ta(5nm) were investigated in this paper. A series of experimental data measured with a MTJ was used to verify a magnon-assisted tunnelling model and theory. Furthermore, a micromagnetics simulation shows that the butterfly-like vortex domain structures can be formed under a current-induced Oersted field, which decreases the net magnetization values of the ferromagnetic electrodes under a large dc current (i.e., in high voltage regimes). It is one of the main reasons for the tunnel magnetoresistance ratios to decrease significantly at high voltage biasing.

  20. Results of Current Density Distribution Mapping in PEM Fuel Cells Dependent on Operation Parameters

    Directory of Open Access Journals (Sweden)

    Zbigniew A. Styczynski

    2013-07-01

    Full Text Available This paper presents in situ measurements of a newly developed current density measurement system for proton exchange membrane fuel cells (PEMFC. While the functional principle and technical evaluation of the measurement system were presented in a previous paper, this paper analyzes the influence of various operation parameters, including multiple start-stop operation, at the anode, cathode and cooling locations on the distribution and long-term development of the current density. The system was operated for 500 h over two years with long periods of inactivity between measurements. The measurement results are evaluated and provide additional information on how to optimize the operation modes of fuel cells, including the start and stop of such systems as well as the water balance.

  1. Strain dependence of the critical current and critical field in multifilamentary Nb3Sn composites

    International Nuclear Information System (INIS)

    Ekin, J.W.

    1979-01-01

    High-J/sub c/ multifilamentary Nb 3 Sn superconductors with widely varying amounts of prestrain and critical field values can be characterized fairly accurately by a single normalized critical field-strain relationship. Such a relationship permits first order prediction of critical-current degradation at arbitrary magnetic field magnitudes with knowledge of only two parameters for any conductor, the prestrain and the maximum critical field. Some of the conductor-fabrication factors affecting the parameters are considered

  2. Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use.

    Science.gov (United States)

    Brown-Rice, Kathleen A; Scholl, Jamie L; Fercho, Kelene A; Pearson, Kami; Kallsen, Noah A; Davies, Gareth E; Ehli, Erik A; Olson, Seth; Schweinle, Amy; Baugh, Lee A; Forster, Gina L

    2018-02-02

    A significant proportion of college students are adult children of an alcoholic parent (ACoA), which can confer greater risk of depression, poor self-esteem, alcohol and drug problems, and greater levels of college attrition. However, some ACoA are resilient to these negative outcomes. The goal of this study was to better understand the psychobiological factors that distinguish resilient and vulnerable college-aged ACoAs. To do so, scholastic performance and psychological health were measured in ACoA college students not engaged in hazardous alcohol use (resilient) and those currently engaged in hazardous alcohol use (vulnerable). Neural activity (as measured by functional magnetic resonance imaging) in response to performing working memory and emotion-based tasks were assessed. Furthermore, the frequency of polymorphisms in candidate genes associated with substance use, risk taking and stress reactivity were compared between the two ACoA groups. College ACoAs currently engaged in hazardous alcohol use reported more anxiety, depression and posttraumatic stress symptoms, and increased risky nicotine and marijuana use as compared to ACoAs resistant to problem alcohol use. ACoA college students with current problem alcohol showed greater activity of the middle frontal gyrus and reduced activation of the posterior cingulate in response to visual working memory and emotional processing tasks, which may relate to increased anxiety and problem alcohol and drug behaviors. Furthermore, polymorphisms of cholinergic receptor and the serotonin transporter genes also appear to contribute a role in problem alcohol use in ACoAs. Overall, findings point to several important psychobiological variables that distinguish ACoAs based on their current alcohol use that may be used in the future for early intervention. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Transcutaneous Spinal Direct Current Stimulation Alters Resting-State Functional Connectivity.

    Science.gov (United States)

    Schweizer, Lauren; Meyer-Frießem, Christine H; Zahn, Peter K; Tegenthoff, Martin; Schmidt-Wilcke, Tobias

    2017-08-01

    Transcutaneous spinal direct current stimulation (tsDCS) is a noninvasive method that can modulate spinal reflexes, sensory afferent conduction, and even pain perception. Although neurophysiological evidence suggests that tsDCS alters somatosensory and nociceptive afferent conduction to the cortex, its supraspinal effects have not yet been investigated by using functional imaging to investigate tsDCS-induced alterations in intrinsic functional connectivity (FC). Therefore, we hypothesize that tsDCS-induced changes in neurophysiological measures might also be reflected in spontaneous brain activity. We investigated tsDCS-induced changes in somatosensory cortical connectivity by using seed-to-voxel-based analyses from the bilateral primary somatosensory cortex (S1) and the thalamus in a double-blind, crossover study design. Resting state FC was measured by using blood oxygenation level-dependent, functional magnetic resonance imaging (3T Philips) before and after anodal, cathodal, and sham tsDCS (20 min, 2.5 mA, active electrode centered over T11 spinous process, reference electrode over left shoulder blade) in a double-blind, crossover study of 20 healthy men (24 ± 0.7 years). As compared with sham, anodal tsDCS resulted in a decreased connectivity between the S1 and the ipsilateral posterior insula for both left and right hemispheres. Anodal tsDCS also resulted in decreased thalamic connectivity with the anterior cingulate cortex, and increased connectivity between S1 and the thalamus. Cathodal tsDCS showed increased FC between the right thalamus and both left and right posterior insulae, and decreased connectivity between the S1 seeds and the occipital cortex. Our results provide evidence of supraspinal effects of tsDCS and suggest that tsDCS may provide a noninvasive intervention that is able to target cortical sensory networks.

  4. Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.

    Science.gov (United States)

    Liu, Pin W; Blair, Nathaniel T; Bean, Bruce P

    2017-10-04

    Action potential (AP) shape is a key determinant of cellular electrophysiological behavior. We found that in small-diameter, capsaicin-sensitive dorsal root ganglia neurons corresponding to nociceptors (from rats of either sex), stimulation at frequencies as low as 1 Hz produced progressive broadening of the APs. Stimulation at 10 Hz for 3 s resulted in an increase in AP width by an average of 76 ± 7% at 22°C and by 38 ± 3% at 35°C. AP clamp experiments showed that spike broadening results from frequency-dependent reduction of potassium current during spike repolarization. The major current responsible for frequency-dependent reduction of overall spike-repolarizing potassium current was identified as Kv3 current by its sensitivity to low concentrations of 4-aminopyridine (IC 50 action potentials of small-diameter rat DRG neurons showed spike broadening at frequencies as low as 1 Hz and that spike broadening resulted predominantly from frequency-dependent inactivation of Kv3 channels. Spike width helps to control transmitter release, conduction velocity, and firing patterns and understanding the role of particular potassium channels can help to guide new pharmacological strategies for targeting pain-sensing neurons selectively. Copyright © 2017 the authors 0270-6474/17/379705-10$15.00/0.

  5. Complex state variable- and disturbance observer-based current controllers for AC drives

    DEFF Research Database (Denmark)

    Dal, Mehmet; Teodorescu, Remus; Blaabjerg, Frede

    2013-01-01

    , extracted by a disturbance observer and then injected into the current controller. In this study, a revised version of a disturbance observer-based controller and a well known complex variable model-based design with a single set of complex pole are compared in terms of design aspects and performance......In vector-controlled AC drives, the design of current controller is usually based on a machine model defined in synchronous frame coordinate, where the drive performance may be degraded by both the variation of the machine parameters and the cross-coupling between the d- and q-axes components...... of the stator current. In order to improve the current control performance an alternative current control strategy was proposed previously aiming to avoid the undesired cross-coupling and non-linearities between the state variables. These effects are assumed as disturbances arisen in the closed-loop path...

  6. State-Dependent Impulsive Control Strategies for a Tumor-Immune Model

    Directory of Open Access Journals (Sweden)

    Kwang Su Kim

    2016-01-01

    Full Text Available Controlling the number of tumor cells leads us to expect more efficient strategies for treatment of tumor. Towards this goal, a tumor-immune model with state-dependent impulsive treatments is established. This model may give an efficient treatment schedule to control tumor’s abnormal growth. By using the Poincaré map and analogue of Poincaré criterion, some conditions for the existence and stability of a positive order-1 periodic solution of this model are obtained. Moreover, we carry out numerical simulations to illustrate the feasibility of our main results and compare fixed-time impulsive treatment effects with state-dependent impulsive treatment effects. The results of our simulations say that, in determining optimal treatment timing, the model with state-dependent impulsive control is more efficient than that with fixed-time impulsive control.

  7. Current State of Environmental Education in Mexico: A Study on Practices, Audiences, Settings, and Topics

    Science.gov (United States)

    Marcos-Iga, Jose; Shaw, William

    2011-01-01

    Environmental education in Mexico takes many forms and plays a wide variety of roles. Through an online survey, we addressed the need to present a wider picture on the current state of environmental education practices in Mexico: Who is engaging in environmental education practices, how important is it for their organization, who are they…

  8. Cryptography in the Cloud Computing: the Current State and Logical Tasks

    OpenAIRE

    Sergey Nikolaevich Kyazhin; Andrey Vladimirovich Moiseev

    2013-01-01

    The current state of the cloud computing (CC) information security is analysed and logical problems of storage and data transmission security at CC are allocated. Cryptographic methods of data security in CC, in particular, lightweight cryptography and the cryptography based on bilinear pairings are described.

  9. Cryptography in the Cloud Computing: the Current State and Logical Tasks

    Directory of Open Access Journals (Sweden)

    Sergey Nikolaevich Kyazhin

    2013-09-01

    Full Text Available The current state of the cloud computing (CC information security is analysed and logical problems of storage and data transmission security at CC are allocated. Cryptographic methods of data security in CC, in particular, lightweight cryptography and the cryptography based on bilinear pairings are described.

  10. A partition-free approach to transient and steady-state charge currents

    DEFF Research Database (Denmark)

    Cornean, Horia; Gianesello, Céline; Zagrebnov, Valentin

    2010-01-01

    We construct a non-equilibrium steady state and calculate the corresponding current for a mesoscopic Fermi system in the partition-free setting. To this end we study a small sample coupled to a finite number of semi-infinite leads. Initially, the whole system of quasi-free fermions is in a grand-...

  11. Atlas of current and potential future distributions of common trees of the eastern United States

    Science.gov (United States)

    Louis R. Iverson; Anantha M. Prasad; Betsy J. Hale; Elaine Kennedy Sutherland

    1999-01-01

    This atlas documents the current and possible future distribution of 80 common tree species in the Eastern United States and gives detailed information on environmental characteristics defining these distributions. Also included are outlines of life history characteristics and summary statistics for these species. Much of the data are derived from Forest Inventory and...

  12. Current State and Development of Tourism in the Republic of Abkhazia

    Directory of Open Access Journals (Sweden)

    Sabina G. Kvekveskiri

    2012-05-01

    Full Text Available The article is concerned with the current state of tourism business in the republic of Abkhazia, which has strong links to politics in the region. The settlement of politic issues will lead the to a perspective development of tourism industry in the short run.

  13. Early Childhood Inclusion in the United States: Goals, Current Status, and Future Directions

    Science.gov (United States)

    Guralnick, Michael J.; Bruder, Mary Beth

    2016-01-01

    The current status and future directions of early childhood inclusion in the United States are discussed from the perspective of 4 key goals: access, accommodations and feasibility, developmental progress, and social integration. Recommendations are put forward to promote inclusion goals emphasizing administrative structures, personnel…

  14. Globalization of Gerontology Education: Current Practices and Perceptions for Graduate Gerontology Education in the United States

    Science.gov (United States)

    Mwangi, Samuel M.; Yamashita, Takashi; Ewen, Heidi H.; Manning, Lydia K.; Kunkel, Suzanne R.

    2012-01-01

    The purpose of this study is to document current practices and understandings about globalization of gerontology education in the United States. Better understanding of aging requires international perspectives in global communities. However, little is known about how globalization of gerontology education is practiced in U.S. graduate-level…

  15. A Sociological Demographic Analysis of the Current State and Evolution of the Family

    Science.gov (United States)

    Golod, S. I.

    2008-01-01

    Starting in the 1960s, researchers in many countries have expressed concern over the state of crisis of monogamy, addressing the phenomenon as a direct function of global social transformations. The author finds it is difficult to agree with the negative assessment of the current status of the family, noting that centuries of evidence confirm the…

  16. Current State of History of Psychology Teaching and Education in Argentina: An Empirical Bibliometric Investigation

    Science.gov (United States)

    Fierro, Catriel; Ostrovsky, Ana Elisa; Di Doménico, María Cristina

    2018-01-01

    This study is an empirical analysis of the field's current state in Argentinian universities. Bibliometric parameters were used to retrieve the total listed texts (N = 797) of eight undergraduate history courses' syllabi from Argentina's most populated public university psychology programs. Then, professors in charge of the selected courses (N =…

  17. Planning for Development in the Arab Gulf States: A content Analysis of Current Development Plans

    DEFF Research Database (Denmark)

    Hvidt, Martin

    2012-01-01

    Abstract: This paper analyses current development plans published by the GCC states (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in order to explore the region’s future growth trajectory: what barriers to growth are foreseen and how can they be anticipated; what...

  18. The Current State of Empirical Support for the Pharmacological Treatment of Selective Mutism

    Science.gov (United States)

    Carlson, John S.; Mitchell, Angela D.; Segool, Natasha

    2008-01-01

    This article reviews the current state of evidence for the psychopharmacological treatment of children diagnosed with selective mutism within the context of its link to social anxiety disorder. An increased focus on potential medication treatment for this disorder has resulted from significant monetary and resource limitations in typical practice,…

  19. Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Philip Ng

    2010-09-01

    Full Text Available Recombinant Adenoviral vectors represent one of the best gene transfer platforms due to their ability to efficiently transduce a wide range of quiescent and proliferating cell types from various tissues and species. The activation of an adaptive immune response against the transduced cells is one of the major drawbacks of first generation Adenovirus vectors and has been overcome by the latest generation of recombinant Adenovirus, the Helper-Dependent Adenoviral (HDAd vectors. HDAds have innovative features including the complete absence of viral coding sequences and the ability to mediate high level transgene expression with negligible chronic toxicity. This review summarizes the many aspects of HDAd biology and structure with a major focus on in vivo gene therapy application and with an emphasis on the unsolved issues that these vectors still presents toward clinical application.

  20. Estimates of Pertussis Vaccine Effectiveness in United States Air Force Pediatric Dependents

    Science.gov (United States)

    2015-06-22

    pediatric dependents 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Greg Wolff, Michael Bell, James Escobar...dependents Greg Wolffa,b,∗, Michael Bell a, James Escobara, Stefani Ruiza,b a United States Air Force School of Aerospace Medicine, 2510 5th...Infect Dis 2010;51(3):315–21. [14] Witt MA, Katz PH, Witt DJ. Unexpectedly limited durability of immunity fol- lowing acellular pertussis vaccination in

  1. Thickness dependence study of current-driven ferromagnetic resonance in Y3Fe5O12/heavy metal bilayers

    Science.gov (United States)

    Fang, Z.; Mitra, A.; Westerman, A. L.; Ali, M.; Ciccarelli, C.; Cespedes, O.; Hickey, B. J.; Ferguson, A. J.

    2017-02-01

    We use ferromagnetic resonance to study the current-induced torques in YIG/heavy metal bilayers. YIG samples with thickness varying from 14.8 nm to 80 nm, with the Pt or Ta thin film on top, are measured by applying a microwave current into the heavy metals and measuring the longitudinal DC voltage generated by both spin rectification and spin pumping. From a symmetry analysis of the FMR lineshape and its dependence on YIG thickness, we deduce that the Oersted field dominates over spin-transfer torque in driving magnetization dynamics.

  2. Decay of autoionizing states in time-dependent density functional and reduced density matrix functional theory

    Energy Technology Data Exchange (ETDEWEB)

    Kapoor, Varun; Brics, Martins; Bauer, Dieter [Institut fuer Physik, Universitaet Rostock, 18051 Rostock (Germany)

    2013-07-01

    Autoionizing states are inaccessible to time-dependent density functional theory (TDDFT) using known, adiabatic Kohn-Sham (KS) potentials. We determine the exact KS potential for a numerically exactly solvable model Helium atom interacting with a laser field that is populating an autoionizing state. The exact single-particle density of the population in the autoionizing state corresponds to that of the energetically lowest quasi-stationary state in the exact KS potential. We describe how this exact potential controls the decay by a barrier whose height and width allows for the density to tunnel out and decay with the same rate as in the ab initio time-dependent Schroedinger calculation. However, devising a useful exchange-correlation potential that is capable of governing such a scenario in general and in more complex systems is hopeless. As an improvement over TDDFT, time-dependent reduced density matrix functional theory has been proposed. We are able to obtain for the above described autoionization process the exact time-dependent natural orbitals (i.e., the eigenfunctions of the exact, time-dependent one-body reduced density matrix) and study the potentials that appear in the equations of motion for the natural orbitals and the structure of the two-body density matrix expanded in them.

  3. State-Dependence and Stepping Stone Effects of Low Pay Employment in Australia

    OpenAIRE

    Cai, Lixin

    2013-01-01

    Using the HILDA Survey, this study examines state-dependence and stepping stone effects of low pay in Australia. The results show that both state-dependence and stepping stone effects of low pay are present after observed and unobserved individual heterogeneity is accounted for. The results also show that, other things being equal, people who are on low pay are more likely to be in employment in the future than those who are either unemployed or not in the labour force. On the other hand, peo...

  4. Temperature dependence of the critical current of the superconducting microladder in zero magnetic field: Theory and experiment

    Energy Technology Data Exchange (ETDEWEB)

    Fink, H.J. (Department of Electrical Engineering and Computer Science, University of California, Davis, Davis, California 95616 (USA)); Buisson, O.; Pannetier, B. (Centre de Recherches sur les Tres Basses Temperature, Centre National de la Recherche Scientifique, Boite Postale 166X, 38042 Grenoble CEDEX, France (FR))

    1991-05-01

    The largest supercurrent which can be injected into a superconducting microladder was calculated as a function of nodal spacing {ital scrL} and temperature for zero magnetic flux using (i) exact solutions of the Ginzburg-Landau equation in terms of Jacobian elliptic functions and (ii) approximate solutions in terms of hyperbolic functions. The agreement is good for {ital scrL}/{xi}({ital T}){lt}3, where {xi}({ital T}) is the temperature-dependent coherence length. Since solution (ii) is much simpler than solution (i), it is of considerable value when calculating critical currents of micronets with nodal spacings comparable to {xi}({ital T}). We find that the temperature-dependent critical current deviates significantly from the classical 3/2 power law of the Ginzburg-Landau theory. Preliminary experiments on a submicrometer ladder confirm such deviations.

  5. Current state and prospects of carbon management in high latitudes of Northern Eurasia

    Science.gov (United States)

    Schepaschenko, Dmitry; Shvidenko, Anatoly

    2010-05-01

    The current state and trajectories of future development of natural landscapes in high latitudes of Northern Eurasia are defined inter alia by (1) current unsatisfactory social and economic situation in boreal Northern Eurasia; (2) the dramatic magnitude of on-going and expected climatic change (warming up to 10-12oC under global warming at 4oC); (3) increasing anthropogenic pressure, particularly in regions of intensive oil and gas exploration and extraction; (4) large areas of sparsely populated and practically unmanaged land; (5) vulnerability of northern ecosystems which historically developed under cold climates and buffering capacity of which is not well known; (6) risk of catastrophic natural disturbances (fire, insect outbreaks) whose frequency and severity have accelerated during recent decades; and (7) high probability of irreversible changes of vegetation cover. These specifics are overlapped with insufficient governance of natural renewable resources (e.g., forests) and destructed practice of industrial development of new territories (oil and gas extraction and exploration, metallurgy etc.). Based on a full carbon account for terrestrial vegetation ecosystems of Northern Eurasia, we analyze the relative impacts of major drivers on magnitude and uncertainty of the Net Ecosystem Carbon Balance (NECB) under current and expected climate and environment. Dynamic trends and interannual variability of NECB are mostly dependent on weather conditions during growth seasons of individual years, regimes of natural disturbances, and anthropogenic impacts on ecosystems. In a short term, disturbances and human impacts cause a theoretically 'manageable' part of the full carbon account, which on average is estimated to be of about 20% of annual net primary production. In a long term, thawing of permafrost and change of hydrological regimes of vast territories may result in a catastrophic decline of the forested area and wide distribution of 'green desertification'. The

  6. Dependence of extinction cross-section on incident polarization state and particle orientation

    International Nuclear Information System (INIS)

    Yang Ping; Wendisch, Manfred; Bi Lei; Kattawar, George; Mishchenko, Michael; Hu, Yongxiang

    2011-01-01

    This note reports on the effects of the polarization state of an incident quasi-monochromatic parallel beam of radiation and the orientation of a hexagonal ice particle with respect to the incident direction on the extinction process. When the incident beam is aligned with the six-fold rotational symmetry axis, the extinction is independent of the polarization state of the incident light. For other orientations, the extinction cross-section for linearly polarized light can be either larger or smaller than its counterpart for an unpolarized incident beam. Therefore, the attenuation of a quasi-monochromatic radiation beam by an ice cloud depends on the polarization state of the beam if ice crystals within the cloud are not randomly oriented. Furthermore, a case study of the extinction of light by a quartz particle is also presented to illustrate the dependence of the extinction cross-section on the polarization state of the incident light.

  7. Energy dependency and sustainable regional development in the Baltic states: A review

    Directory of Open Access Journals (Sweden)

    Štreimikienė Dalia

    2016-01-01

    Full Text Available Energy security is one of the most important indicators of sustainable regional development and 'green' growth in implementation of EU strategy Europe 2020. It can provide the harmonized development and cohesion of 'old' and 'new' EU member states. Our paper conducts a comparative study of energy dependency and energy security indicators in the Baltic States. The Baltic countries achieved enormous progress in the use of renewable energy sources and energy efficiency since their EU accession in 2004. The increase of renewable energy capacities in Baltic States also contributed to the reduction of energy intensity and carbon intensity of economy and energy import dependency. Our results show that amongst all three states, it was Estonia that had achieved the best results in increased use of renewables and energy efficiency improvements and had distinguished itself with the best indicators and economic and regional policy outcomes.

  8. Resistive states created in superconducting NbTiN filaments by an electrical current pulse

    Directory of Open Access Journals (Sweden)

    K. Harrabi

    2015-03-01

    Full Text Available We have observed as a function of the time the appearance of the voltage caused by a larger-than-critical (I > Ic step-pulse of current in narrow NbTiN strips at 4.2 K. Different current intensities produced either phase-slip centres characterized by a voltage saturating with the time, or ever expanding hot spots. These dissipative structures occur after a measurable delay time, whose dependence upon the ratio I/Ic can be analysed through a Ginzburg-Landau theory to yield a unique adjustable time constant.

  9. Visualizing the mechanism that determines the critical current density in polycrystalline superconductors using time-dependent Ginzburg-Landau theory.

    OpenAIRE

    Carty, G. J.; Hampshire, D. P.

    2008-01-01

    In polycrystalline superconducting materials optimized for high critical current density (JC) in high magnetic fields, the mechanism that determines JC has long remained uncertain because of the complicated manner in which the fluxon-fluxon and fluxon-microstructure forces combine. In this work, the time-dependent Ginzburg-Landau equations are used to produce visualizations of fluxons at JC that show the disorder in the pinned part of the flux-line lattice and the motion of those fluxons alon...

  10. The Current Status of the State Financial Audit in Ukraine and Prospects of its Development

    Directory of Open Access Journals (Sweden)

    Dolbneva Deniza V.

    2017-11-01

    Full Text Available The article is aimed at studying the current status and determining the main results of conducting the State financial audit by the State audit service in Ukraine, as well as developing proposals as to ways of its improvement in view of the experience of the world’s leading countries and the requirements of international standards in this sphere of relations. The main indicators and results, which characterize the status of conducting by bodies of the State Audit Service of the State financial audit on key directions, were considered. The obtained data indicate that the State financial audit is taking place in the direction corresponding to international practice. Today, however, because of a number of problems and declarative provisions related to the organization and conduct of the State financial audit, it cannot fully implement all its functional capabilities and tasks. Directions of improvement and transformation of the State financial audit have been proposed. The prospect for further research is development of a holistic mechanism for the functioning of the State financial audit, which will unite all its directions at different levels and its participants.

  11. Current Pressure Transducer Application of Model-based Prognostics Using Steady State Conditions

    Science.gov (United States)

    Teubert, Christopher; Daigle, Matthew J.

    2014-01-01

    Prognostics is the process of predicting a system's future states, health degradation/wear, and remaining useful life (RUL). This information plays an important role in preventing failure, reducing downtime, scheduling maintenance, and improving system utility. Prognostics relies heavily on wear estimation. In some components, the sensors used to estimate wear may not be fast enough to capture brief transient states that are indicative of wear. For this reason it is beneficial to be capable of detecting and estimating the extent of component wear using steady-state measurements. This paper details a method for estimating component wear using steady-state measurements, describes how this is used to predict future states, and presents a case study of a current/pressure (I/P) Transducer. I/P Transducer nominal and off-nominal behaviors are characterized using a physics-based model, and validated against expected and observed component behavior. This model is used to map observed steady-state responses to corresponding fault parameter values in the form of a lookup table. This method was chosen because of its fast, efficient nature, and its ability to be applied to both linear and non-linear systems. Using measurements of the steady state output, and the lookup table, wear is estimated. A regression is used to estimate the wear propagation parameter and characterize the damage progression function, which are used to predict future states and the remaining useful life of the system.

  12. Reducing the iron burden and improving survival in transfusion-dependent thalassemia patients: current perspectives

    Directory of Open Access Journals (Sweden)

    Bayanzay K

    2016-08-01

    Full Text Available Karim Bayanzay, Lama Alzoebie Department of Hematology, Gulf Medical University, Ajman, United Arab Emirates Abstract: Hypertransfusion regimens for thalassemic patients revolutionized the management of severe thalassemia; transforming a disease which previously led to early infant death into a chronic condition. The devastating effect of the accrued iron from chronic blood transfusions necessitates a more finely tuned approach to limit the complications of the disease, as well as its treatment. A comprehensive approach including carefully tailored transfusion protocol, continuous monitoring and assessment of total body iron levels, and iron chelation are currently the mainstay in treating iron overload. There are also indications for ancillary treatments, such as splenectomy and fetal hemoglobin induction. The main cause of death in iron overload continues to be related to cardiac complications. However, since the widespread use of iron chelation started in the 1970s, there has been a general improvement in survival in these patients. Keywords: hematology, chelators, deferoxamine, deferiserox, deferiprone, liver iron concentration, iron overload, serum ferritin concentration, hepatic iron storage, iron chelation therapy

  13. Is effect of transcranial direct current stimulation on visuomotor coordination dependent on task difficulty?

    Directory of Open Access Journals (Sweden)

    Yong Hyun Kwon

    2015-01-01

    Full Text Available Transcranial direct current stimulation (tDCS, an emerging technique for non-invasive brain stimulation, is increasingly used to induce changes in cortical excitability and modulate motor behavior, especially for upper limbs. The purpose of this study was to investigate the effects of tDCS of the primary motor cortex on visuomotor coordination based on three levels of task difficulty in healthy subjects. Thirty-eight healthy participants underwent real tDCS or sham tDCS. Using a single-blind, sham-controlled crossover design, tDCS was applied to the primary motor cortex. For real tDCS conditions, tDCS intensity was 1 mA while stimulation was applied for 15 minutes. For the sham tDCS, electrodes were placed in the same position, but the stimulator was turned off after 5 seconds. Visuomotor tracking task, consisting of three levels (levels 1, 2, 3 of difficulty with higher level indicating greater difficulty, was performed before and after tDCS application. At level 2, real tDCS of the primary motor cortex improved the accurate index compared to the sham tDCS. However, at levels 1 and 3, the accurate index was not significantly increased after real tDCS compared to the sham tDCS. These findings suggest that tasks of moderate difficulty may improve visuomotor coordination in healthy subjects when tDCS is applied compared with easier or more difficult tasks.

  14. Current trends for improving the design of membrane devices for photoautotrophic biosynthesis is light dependent microorganisms

    Directory of Open Access Journals (Sweden)

    A. A. Shevtsov

    2016-01-01

    Full Text Available Modern trends in improving the design of membrane devices for photoautotrophic biosynthesis dependent lighting microorganisms aimed at a significant increase in the productivity of valuable products from biomass of microalgae and obtaining on the basis of their individual useful substances (drugs used in various industries and medicine. In film devices effectively the processes of heat - and mass-exchange with the gas comes into contact with the culture fluid flowing as a film on a transparent film-forming surface is STI in its light intensity and autotrophic biosynthesis occurs only in the presence of a mixture of air with carbon dioxide. Thus, completely eliminated the accumulation of metabolic products due to their continuous removal from film culture liquid with the process gas, which is not typical for devices of other types. Small size membrane bioreactors may increase the degree of saturation of the liquid carbon dioxide with the possibility of changing the concentration of gas in the culture fluid and to ensure the cultivation of microorganisms with a specified biomass yield. At present up to date-developed a significant number of ways to ensure contact of the gas with the liquid (bubbling, gas-lift, mechanical stirring, jet, membrane, etc. on the basis of which an industrial bioreactor, with various "stress" effect. It is believed that for the cultivation of the most optimal are bioreactors with mechanical stirring of the liquid, which allow the greatest productivity of biomass. However, the applied model of a mechanical mixing device to create a work whose cavity of the bioreactor chaotic, disorganized mixing, which contributes to the emergence, insufficient for the sustenance of the cell cultures and microorganisms. Analysis of the interactions of the gas with the liquid film devices showed the need to create a new generation of bioreactor with intensive mass transfer without the possibility of limiting the productivity of

  15. Race/Ethnic Disparities in the Utilization of Treatment for Drug Dependent Inmates in U.S. State Correctional Facilities

    Science.gov (United States)

    Nowotny, Kathryn M.

    2014-01-01

    This study examines race/ethnic disparities in treatment for drug dependent inmates in state correctional facilities. The data come from the 2004 Survey of Inmates in State Correctional Facilities. Fixed effects logistic regression is used to analyze treatment outcomes for 5,180 inmates housed within 286 prisons. The analysis accounts for differences in background characteristics (i.e., age, gender, marital status, foreign born status, veteran status), socioeconomic characteristics (i.e., education, employment prior to incarceration), mental health (i.e., diagnosis with a serious mental illness), and incarceration experiences (i.e., current conviction, previous incarceration episodes, time served, additional sentencing requirements, external social support, disciplinary violations). The findings identify a remarkable unmet need among drug dependent inmates in that less than one-half of drug dependent inmates had received any type of treatment in prison at the time of the interview with the most common treatment type being self-help groups. Compared to whites, drug dependent Latino inmates have significantly lower odds of utilizing treatment, yet there are no significant black-white disparities found. Implications for drug treatment within prisons are discussed. PMID:25270722

  16. Acute Poisoning Surveillance in Thailand: The Current State of Affairs and a Vision for the Future

    OpenAIRE

    Saoraya, Jutamas; Inboriboon, Pholaphat Charles

    2013-01-01

    Acute poisoning is a major public health threat worldwide, including Thailand, a country in Southeast Asia with over 67 million inhabitants. The incidence and characteristics of poisoning in Thailand vary greatly depending on the reporting body. This systematic review aims to provide a comprehensive description of the state of poisoning in Thailand. It identifies common trends and differences in poisoning by reporting centers and regional studies. Almost half of the cases and three-fourths of...

  17. Implications of rf current drive theory for next step steady-state tokamak design

    International Nuclear Information System (INIS)

    Schultz, J.H.

    1985-06-01

    Two missions have been identified for a next-step tokamak experiment in the United States. The more ambitious Mission II device would be a superconducting tokamak, capable of doing long-pulse ignition demonstrations, and hopefully capable of also being able to achieve steady-state burn. A few interesting lines of approach have been identified, using a combination of logical design criteria and parametric system scans [SC85]. These include: (1) TIBER: A point-design suggested by Lawrence Livermore, that proposes a machine with the capability of demonstrating ignition, high beta (10%) and high Q (=10), using high frequency, fast-wave current drive. The TIBER topology uses moderate aspect ratio and high triangularity to achieve high beta. (2) JET Scale-up. (3) Magic5: It is argued here that an aspect ratio of 5 is a magic number for a good steady-state current drive experiment. A moderately-sized machine that achieves ignition and is capable of high Q, using either fast wave or slow wave current drive is described. (4) ET-II: The concept of a highly elongated tokamak (ET) was first proposed as a low-cost approach to Mission I, because of the possibility of achieving ohmic ignition with low-stress copper magnets. We propose that its best application is really for commercial tokamaks, using fast-wave current drive, and suggest a Mission II experiment that would be prototypical of such a reactor

  18. Lower bounds for ballistic current and noise in non-equilibrium quantum steady states

    Directory of Open Access Journals (Sweden)

    Benjamin Doyon

    2015-03-01

    Full Text Available Let an infinite, homogeneous, many-body quantum system be unitarily evolved for a long time from a state where two halves are independently thermalized. One says that a non-equilibrium steady state emerges if there are nonzero steady currents in the central region. In particular, their presence is a signature of ballistic transport. We analyze the consequences of the current observable being a conserved density; near equilibrium this is known to give rise to linear wave propagation and a nonzero Drude peak. Using the Lieb–Robinson bound, we derive, under a certain regularity condition, a lower bound for the non-equilibrium steady-state current determined by equilibrium averages. This shows and quantifies the presence of ballistic transport far from equilibrium. The inequality suggests the definition of “nonlinear sound velocities”, which specialize to the sound velocity near equilibrium in non-integrable models, and “generalized sound velocities”, which encode generalized Gibbs thermalization in integrable models. These are bounded by the Lieb–Robinson velocity. The inequality also gives rise to a bound on the energy current noise in the case of pure energy transport. We show that the inequality is satisfied in many models where exact results are available, and that it is saturated at one-dimensional criticality.

  19. The Current Mental State of School Students in Online Learning Conditions

    Directory of Open Access Journals (Sweden)

    Kovalevskaya E.V.,

    2015-08-01

    Full Text Available This article discusses the results of a study of actual mental state of high school students who are active subjects of career self-determination in terms of interactive learning. There are four groups of methods of interactive training: psychological training, art therapy, cognitive, and game training. The main task, which is solved by a researcher in a formative experiment with the use of each of these methods, is to establish significant differences in health, activity and mood as the indicators of current mental state of students in the classroom. As a result, we found that the most significant improvements in the current mental state takes place when using art and game therapy, so these techniques should be used in groups of students with low motivation to work, as well as in the adverse psychological climate. Less significant was the improvement of the current mental state after psychological training due to the fact that this method allow to update and seek solutions to the most important intrapersonal issues and require the implementation of a deeper reflection

  20. Comparison of three different concepts of high dynamic range and dependability optimised current measurement digitisers for beam loss systems

    CERN Document Server

    Viganò, W; Effinger, E; Venturini, G G; Zamantzas, C

    2012-01-01

    Three Different Concepts of High Dynamic Range and Dependability Optimised Current Measurement Digitisers for Beam Loss Systems will be compared on this paper. The first concept is based on Current to Frequency Conversion, enhanced with an ADC for extending the dynamic range and decreasing the response time. A summary of 3 years’ worth of operational experience with such a system for LHC beam loss monitoring will be given. The second principle is based on an Adaptive Current to Frequency Converter implemented in an ASIC. The basic parameters of the circuit are discussed and compared with measurements. Several measures are taken to harden both circuits against single event effects and to make them tolerant for operation in radioactive environments. The third circuit is based on a Fully Differential Integrator for enhanced dynamic range, where laboratory and test installation measurements will be presented. All circuits are designed to avoid any dead time in the acquisition and have reliability and fail safe...

  1. Transport characteristics of n-ZnO/p-Si heterojunction as determined from temperature dependent current-voltage measurements

    Science.gov (United States)

    Djiokap, S. R. Tankio; Urgessa, Z. N.; Mbulanga, C. M.; Venter, A.; Botha, J. R.

    2016-01-01

    Zinc oxide (ZnO) nanorods have been synthesized by a two-step chemical bath deposition process on silicon substrates having different dopant densities and orientations. Scanning electron microscopy and X-ray diffraction analysis reveal that the orientation of the Si substrate does not affect the orientation, distribution or crystallinity of the nanostructures. The electrical properties of the ZnO/Si heterojunction are also investigated by current-voltage (I-V) measurements. The ideality factor is found to be 2.6 at 295 K, indicating that complex current transport mechanisms are at play. Temperature dependent I-V characteristics have been used to determine the dominant transport mechanism. The experimental results suggest that in the low bias region the current is dominated by a trap assisted multi-step tunneling process.

  2. Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjaer; Bergdahl, Andreas; Christophersen, Palle

    2007-01-01

    Recent evidence implicates the volume-regulated anion current (VRAC) and other anion currents in control or modulation of cell cycle progression; however, the precise involvement of anion channels in this process is unclear. Here, Cl- currents in Ehrlich Lettre Ascites (ELA) cells were monitored......+ in the pipette), was unaltered from G0 to G1, but decreased in early S phase. A novel high-affinity anion channel inhibitor, the acidic di-aryl-urea NS3728, which inhibited both VRAC and CaCC, attenuated ELA cell growth, suggesting a possible mechanistic link between cell cycle progression and cell cycle......-dependent changes in the capacity for conductive Cl- transport. It is suggested that in ELA cells, entrance into the S phase requires an increase in VRAC activity and/or an increased potential for regulatory volume decrease (RVD), and at the same time a decrease in CaCC magnitude....

  3. Spin force and the generation of sustained spin current in time-dependent Rashba and Dresselhaus systems

    International Nuclear Information System (INIS)

    Ho, Cong Son; Tan, Seng Ghee; Jalil, Mansoor B. A.

    2014-01-01

    The generation of spin current and spin polarization in a two-dimensional electron gas structure is studied in the presence of Dresselhaus and Rashba spin-orbit couplings (SOC), the strength of the latter being modulated in time by an ac gate voltage. By means of the non-Abelian gauge field approach, we established the relation between the Lorentz spin force and the spin current in the SOC system, and showed that the longitudinal component of the spin force induces a transverse spin current. For a constant (time-invariant) Rashba system, we recover the universal spin Hall conductivity of e/(8π) , derived previously via the Berry phase and semi-classical methods. In the case of a time-dependent SOC system, the spin current is sustained even under strong impurity scattering. We evaluated the ac spin current generated by a time-modulated Rashba SOC in the absence of any dc electric field. The magnitude of the spin current reaches a maximum when the modulation frequency matches the Larmor frequency of the electrons

  4. Negative-ion current density dependence of the surface potential of insulated electrode during negative-ion implantation

    International Nuclear Information System (INIS)

    Tsuji, Hiroshi; Okayama, Yoshio; Toyota, Yoshitaka; Gotoh, Yasuhito; Ishikawa, Junzo; Sakai, Shigeki; Tanjyo, Masayasu; Matsuda, Kouji.

    1994-01-01

    Positive ion implantation has been utilized as the method of impurity injection in ultra-LSI production, but the problem of substrate charging cannot be resolved by conventional charge compensation method. It was forecast that by negative ion implantation, this charging problem can be resolved. Recently the experiment on the negative ion implantation into insulated electrodes was carried out, and the effect of negative ion implantation to this problem was proved. However, the dependence of charged potential on the increase of negative ion current at the time of negative ion implantation is a serious problem in large current negative ion implantation hereafter. The charged potential of insulated conductor substrates was measured by the negative ion implantation using the current up to several mA/cm 2 . The experimental method is explained. Medium current density and high current density negative ion implantation and charged potential are reported. Accordingly in negative ion implantation, if current density is optimized, the negative ion implantation without charging can be realized. (K.I.)

  5. Depth-dependent effects of culling—do mesophotic lionfish populations undermine current management?

    Science.gov (United States)

    Grey, Rachel; Hendrix, Alicia; Hitchner, Drew; Gress, Erika; Madej, Konrad; Parry, Rachel L.; Régnier-McKellar, Catriona; Jones, Owen P.; Arteaga, María; Izaguirre, Andrea P.; Rogers, Alex D.; Exton, Dan A.

    2017-01-01

    Invasive lionfish (Pterois volitans and P. miles) have spread widely across the western Atlantic and are recognized as a major threat to native marine biodiversity. Although lionfish inhabit both shallow reefs and mesophotic coral ecosystems (MCEs; reefs from 30 to 150 m depth), the primary management response implemented by many countries has been diver-led culling limited to reefs less than 30 m. However, many reef fish undergo ontogenetic migrations, with the largest and therefore most fecund individuals found at greatest depths. Here, we study lionfish density, body size, maturity and dietary patterns across the depth gradient from the surface down to 85 m on heavily culled reefs around Utila, Honduras. We found lionfish at increased densities, body size and weight on MCEs compared with shallow reefs, with MCEs also containing the greatest proportion of actively spawning females, while shallow reefs contained the greatest proportion of immature lionfish. We then compared lionfish behaviour in response to divers on shallow culled and mesophotic unculled Utilan reefs, and on shallow unculled reefs in Tela Bay, on the Honduran mainland. We found that mesophotic lionfish exhibited high alert distances, consistent with individuals previously exposed to culling despite being below the depth limits of removal. In addition, when examining stomach content, we found that fish were the major component of lionfish diets across the depth gradient. Importantly, our results suggest that despite adjacent shallow culling, MCEs retain substantial lionfish populations that may be disproportionately contributing towards continued lionfish recruitment onto the shallow reefs of Utila, potentially undermining current culling-based management. PMID:28573007

  6. Generalized Coherent States of a Particle in a Time-Dependent Linear Potential

    International Nuclear Information System (INIS)

    Krache, L.; Maamache, M.; Saadi, Y.; Beniaiche, A.

    2009-01-01

    We derive, with an invariant operator method and unitary transformation approach, that the Schrödinger equation with a time-dependent linear potential possesses an infinite string of shape-preseving wave-packet states |φα,λ(t)) having classical motion. The qualitative properties of the invariant eigenvalue spectrum (discrete or continuous) are described separately for the different values of the frequency ω of a harmonic oscillator. It is also shown that, for a discrete eigenvalue spectrum, the states |φα,n(t)) could be obtained from the coherent state |φα,0(t)). (general)

  7. Intensity-dependent change in polarization state of light in normal ...

    Indian Academy of Sciences (India)

    Intensity-dependent change in polarization state of light in normal incidence on an isotropic nonlinear Kerr medium. Hari Prakash Devendra K ... Devendra K Singh2. Department of Physics, University of Allahabad, Allahabad 211 002, India; Department of Physics, Udai Pratap Autonomous College, Varanasi 221 002, India ...

  8. State-Dependent Alterations in Inhibitory Control and Emotional Face Identification in Seasonal Affective Disorder

    DEFF Research Database (Denmark)

    Hjordt, Liv V.; Stenbæk, Dea S.; Madsen, Kathrine Skak

    2017-01-01

    in the symptomatic phase, but not in the remitted phase. The affective biases in cognitive processing constitute state-dependent features of SAD. Our data show that reinstatement of a normal affective cognition should be possible and would constitute a major goal in psychiatric treatment to improve the quality...

  9. Semilinear functional differential equations of fractional order with state-dependent delay

    OpenAIRE

    Mohamed Abdalla Darwish; Sotiris K. Ntouyas

    2009-01-01

    In this paper we study the existence of solutions for the initial value problem for semilinear functional differential equations of fractional order with state-dependent delay. The nonlinear alternative of Leray-Schauder type is the main tool in our analysis.

  10. Semilinear functional differential equations of fractional order with state-dependent delay

    Directory of Open Access Journals (Sweden)

    Mohamed Abdalla Darwish

    2009-03-01

    Full Text Available In this paper we study the existence of solutions for the initial value problem for semilinear functional differential equations of fractional order with state-dependent delay. The nonlinear alternative of Leray-Schauder type is the main tool in our analysis.

  11. ON THE ANISOTROPIC NORM OF DISCRETE TIME STOCHASTIC SYSTEMS WITH STATE DEPENDENT NOISE

    Directory of Open Access Journals (Sweden)

    Isaac Yaesh

    2013-01-01

    Full Text Available The purpose of this paper is to determine conditions for the bound-edness of the anisotropic norm of discrete-time linear stochastic sys-tems with state dependent noise. It is proved that these conditions canbe expressed in terms of the feasibility of a specific system of matrixinequalities.

  12. Impulsive evolution inclusions with state-dependent delay and multivalued jumps

    Directory of Open Access Journals (Sweden)

    Mouffak Benchohra

    2013-07-01

    Full Text Available In this paper we prove the existence of a mild solution for a class of impulsive semilinear evolution differential inclusions with state-dependent delay and multivalued jumps in a Banach space. We consider the cases when the multivalued nonlinear term takes convex values as well as nonconvex values.

  13. Stability properties of a heat equation with state-dependent parameters and asymmetric boundary conditions

    DEFF Research Database (Denmark)

    Backi, Christoph Josef; Bendtsen, Jan Dimon; Leth, John

    2015-01-01

    In this work the stability properties of a partial differential equation (PDE) with state-dependent parameters and asymmetric boundary conditions are investigated. The PDE describes the temperature distribution inside foodstuff, but can also hold for other applications and phenomena. We show...

  14. Existence of periodic solutions for Rayleigh equations with state-dependent delay

    Directory of Open Access Journals (Sweden)

    Jehad O. Alzabut

    2012-05-01

    Full Text Available We establish sufficient conditions for the existence of periodic solutions for a Rayleigh-type equation with state-dependent delay. Our approach is based on the continuation theorem in degree theory, and some analysis techniques. An example illustrates that our approach to this problem is new.

  15. State-dependent bulk-boundary maps and black hole complementarity

    NARCIS (Netherlands)

    Papadodimas, Kyriakos; Raju, Suvrat

    2014-01-01

    We provide a simple and explicit construction of local bulk operators that describe the interior of a black hole in the AdS/CFT correspondence. The existence of these operators is predicated on the assumption that the mapping of CFT operators to local bulk operators depends on the state of the CFT.

  16. Alternative proof with interpretations for a recent state-dependent importance sampling scheme

    NARCIS (Netherlands)

    de Boer, Pieter-Tjerk; Scheinhardt, Willem R.W.

    Recently, a state-dependent change of measure for simulating overflows in the two-node tandem queue was proposed by Dupuis et al. (2005), together with a proof of its asymptotic efficiency. In the present paper, we present an alternative, shorter and simpler proof. Furthermore, we give intuitive

  17. Noise-intolerance and state-dependent factors in patients with whiplash associated disorder

    NARCIS (Netherlands)

    Blokhorst, M.G.B.G.; Meeldijk, S.J.; Luijtelaar, E.L.J.M. van; Toor, T. van; Lousberg, R.; Ganzevles, P.

    2005-01-01

    An experiment was carried out in which the level of noise-intolerance in patients with a Whiplash Associated Disorder (WAD) was compared to healthy matched control subjects. In addition, the relationship between state-dependent factors (as headache, neck pain, fatigue and tension) and

  18. Degradation of Leakage Currents in Solid Tantalum Capacitors Under Steady-State Bias Conditions

    Science.gov (United States)

    Teverovsky, Alexander A.

    2010-01-01

    Degradation of leakage currents in various types of solid tantalum capacitors under steady-state bias conditions was investigated at temperatures from 105 oC to 170 oC and voltages up to two times the rated voltage. Variations of leakage currents with time under highly accelerated life testing (HALT) and annealing, thermally stimulated depolarization currents, and I-V characteristics were measured to understand the conduction mechanism and the reason for current degradation. During HALT the currents increase gradually up to three orders of magnitude in some cases, and then stabilize with time. This degradation is reversible and annealing can restore the initial levels of leakage currents. The results are attributed to migration of positively charged oxygen vacancies in tantalum pentoxide films that diminish the Schottky barrier at the MnO2/Ta2O5 interface and increase electron injection. A simple model allows for estimation of concentration and mobility of oxygen vacancies based on the level of current degradation.

  19. Steady-state configurations of Dzyaloshinskii domain walls driven by field and current

    International Nuclear Information System (INIS)

    Sánchez-Tejerina, L.; Alejos, O.; Martínez, E.

    2017-01-01

    The dynamics of Dzyaloshinskii domain walls (DDW) in ultrathin ferromagnetic strips with perpendicular magnetic anisotropy, for different values of both perpendicular field and longitudinal current excitation associated to the Spin-Hall effect, has been studied, taking into account different values of the interfacial Dzyaloshinskii-Moriya interaction (DMI). This study has been carried out with the help of the q-Φ one-dimensional model and micromagnetic simulations. We have found that Walker breakdown may be avoided by applying a certain threshold current, even though the inverse effect is also possible. We have also found that, for particular values of field and current, the magnetization within the DDW experiences an abrupt change of orientation, which provokes a change on the contribution of current to the terminal DDW velocity. This effect disappears for sufficiently strong DMI, as it is expected from the model. - Highlights: • Steady-state configurations of Dzyaloshinskii domain walls driven by field and current have been reported. • Field-like torques and Slonczewskii-like torques due to spin-orbit interactions have been considered. • The response is associated with the rotation of the domain wall inner magnetization. • An asymmetric behavior arising from the existence of degenerate states is shown. • The asymmetry results in different travelled distances and/or terminal speeds.

  20. Steady-state configurations of Dzyaloshinskii domain walls driven by field and current

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez-Tejerina, L., E-mail: luis.st@ee.uva.es [Departamento de Electricidad y Electrónica, Facultad de Ciencias, Universidad de Valladolid, 47011 Valladolid (Spain); Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Salamanca, 37011 Salamanca (Spain); Alejos, O. [Departamento de Electricidad y Electrónica, Facultad de Ciencias, Universidad de Valladolid, 47011 Valladolid (Spain); Martínez, E. [Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Salamanca, 37011 Salamanca (Spain)

    2017-02-01

    The dynamics of Dzyaloshinskii domain walls (DDW) in ultrathin ferromagnetic strips with perpendicular magnetic anisotropy, for different values of both perpendicular field and longitudinal current excitation associated to the Spin-Hall effect, has been studied, taking into account different values of the interfacial Dzyaloshinskii-Moriya interaction (DMI). This study has been carried out with the help of the q-Φ one-dimensional model and micromagnetic simulations. We have found that Walker breakdown may be avoided by applying a certain threshold current, even though the inverse effect is also possible. We have also found that, for particular values of field and current, the magnetization within the DDW experiences an abrupt change of orientation, which provokes a change on the contribution of current to the terminal DDW velocity. This effect disappears for sufficiently strong DMI, as it is expected from the model. - Highlights: • Steady-state configurations of Dzyaloshinskii domain walls driven by field and current have been reported. • Field-like torques and Slonczewskii-like torques due to spin-orbit interactions have been considered. • The response is associated with the rotation of the domain wall inner magnetization. • An asymmetric behavior arising from the existence of degenerate states is shown. • The asymmetry results in different travelled distances and/or terminal speeds.

  1. [POSTRESUSCITATION CICATRICIAL TRACHEAL STENOSIS. CURRENT STATE OF THE PROBLEM - THE SUCCESSES, THE HOPES AND DISAPPOINTMENTS.

    Science.gov (United States)

    Parshin, V D; Vyzhigina, M A; Rusakov, M A; Parshin, V V; Titov, V A; Starostin, A V

    2016-09-01

    Currently, the trend continues to increase the number ofpatients with cicatricial tracheal stenosis (CTS). Therefore, prevention and treatment ofthis disease remains topical. The main cause ofcicatricial tracheal stenosis is damaging the trachea during mechanical ventilation. The scheme ofprevention of this disease in Russia hasn't brought the desired results. to clarify the modern etiology of cicatricial tracheal stenosis, to identify the trend in incidence rates, to determine whether there is an optimal safe alternative to tracheostomy including the use of minimally invasive techniques, to improve diagnostic and therapeutic algorithm at various stages of assistance, and also to study the results of innovative operations and new ways of maintaining gas exchange. 1128 patients with cicatricial tracheal stenosis was treated from 1963 to 2015 in Petrovsky National Research Centre of Surgery and IMSechenov First Moscow State Medical University. Over time methods of di- agnosis, methods of anesthesia and operations have been varied. In this regard all patients were divided into two groups depending on the period of time from 1963 to 2000 (297 patients) andfrom 2001 to 2015 (831 patients). In recent decades there is a steady increase in the number of treated patients. So, if in the first group during the year operational treatment about the CTS 8,0 patients were underwent, in the second - to 55.4. Cicatricial tracheal stenosis appeared after lung mechanical ventilation at 1025 (for 90.9%) patients. They have undergone both radical one-stage treatment and multi-stage and sequential intraluminal procedures. In general there is a clear trend towards more aggressive surgical tactics. So, if in thefirst group, the tracheal resection with anastomosis was performedin 59 patients only, the second-330. Thefrequency ofpostoperative complications and mortality in the second group ofpatients was 12.9 and 0.7 %, respectively. Only a reasonable combination of all treatment methods

  2. Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia.

    Science.gov (United States)

    Wendt, Stefan; Wogram, Emile; Korvers, Laura; Kettenmann, Helmut

    2016-06-08

    Cortical spreading depression (CSD) is a propagating event of neuronal depolarization, which is considered as the cellular correlate of the migraine aura. It is characterized by a change in the intrinsic optical signal and by a negative DC potential shift. Microglia are the resident macrophages of the CNS and act as sensors for pathological changes. In the present study, we analyzed whether microglial cells might sense CSD by recording membrane currents from microglia in acutely isolated cortical mouse brain slices during an experimentally induced CSD. Coincident with the change in the intrinsic optical signal and the negative DC potential shift we recorded an increase in potassium conductance predominantly mediated by K(+) inward rectifier (Kir)2.1, which was blocked by the NMDA receptor antagonist D-AP5. Application of NMDA and an increase in extracellular K(+) mimics the CSD-induced Kir activation. Application of D-AP5, but not the purinergic receptor antagonist RB2, blocks the NMDA-induced Kir activation. The K(+) channel blocker Ba(2+) blocks both the CSD- and the NMDA-triggered increase in Kir channel activity. In addition, we could confirm previous findings that microglia in the adult brain do not express functional NMDA receptors by recording from microglia cultured from adult brain. From these observations we conclude that CSD activates neuronal NMDA receptors, which lead to an increase in extracellular [K(+)] resulting in the activation of Kir channel activity in microglia. Cortical spreading depression (CSD) is a wave of neuronal depolarization spreading through the cortex and is associated with the aura of migraine. Here we show that microglial cells, which are viewed as pathologic sensors of the brain, can sense this wave. The increase in the extracellular potassium concentration associated with that wave leads to the activation of an inward rectifying potassium conductance in microglia. The involvement of neuronal NMDA receptors is crucial because

  3. State-dependency effects on TMS: a look at motive phosphene behavior.

    Science.gov (United States)

    Najib, Umer; Horvath, Jared C; Silvanto, Juha; Pascual-Leone, Alvaro

    2010-12-28

    Transcranial magnetic stimulation (TMS) is a non-invasive neurostimulatory and neuromodulatory technique that can transiently or lastingly modulate cortical excitability (either increasing or decreasing it) via the application of localized magnetic field pulses. Within the field of TMS, the term state dependency refers to the initial, baseline condition of the particular neural region targeted for stimulation. As can be inferred, the effects of TMS can (and do) vary according to this primary susceptibility and responsiveness of the targeted cortical area. In this experiment, we will examine this concept of state dependency through the elicitation and subjective experience of motive phosphenes. Phosphenes are visually perceived flashes of small lights triggered by electromagnetic pulses to the visual cortex. These small lights can assume varied characteristics depending upon which type of visual cortex is being stimulated. In this particular study, we will be targeting motive phosphenes as elicited through the stimulation of V1/V2 and the V5/MT+ complex visual regions.

  4. Estimation of time- and state-dependent delays and other parameters in functional differential equations

    Science.gov (United States)

    Murphy, K. A.

    1990-01-01

    A parameter estimation algorithm is developed which can be used to estimate unknown time- or state-dependent delays and other parameters (e.g., initial condition) appearing within a nonlinear nonautonomous functional differential equation. The original infinite dimensional differential equation is approximated using linear splines, which are allowed to move with the variable delay. The variable delays are approximated using linear splines as well. The approximation scheme produces a system of ordinary differential equations with nice computational properties. The unknown parameters are estimated within the approximating systems by minimizing a least-squares fit-to-data criterion. Convergence theorems are proved for time-dependent delays and state-dependent delays within two classes, which say essentially that fitting the data by using approximations will, in the limit, provide a fit to the data using the original system. Numerical test examples are presented which illustrate the method for all types of delay.

  5. He 2++ molecular ion in a strong time-dependent magnetic field: a current-density functional study.

    Science.gov (United States)

    Vikas

    2011-08-01

    The He 2++ molecular ion exposed to a strong ultrashort time-dependent (TD) magnetic field of the order of 10(9) G is investigated through a quantum fluid dynamics (QFD) and current-density functional theory (CDFT) based approach using vector exchange-correlation (XC) potential and energy density functional that depend not only on the electronic charge-density but also on the current density. The TD-QFD-CDFT computations are performed in a parallel internuclear-axis and magnetic field-axis configuration at the field-free equilibrium internuclear separation R = 1.3 au with the field-strength varying between 0 and 10(11) G. The TD behavior of the exchange- and correlation energy of the He 2++ is analyzed and compared with that obtained using a [B-TD-QFD-density functional theory (DFT)] approach based on the conventional TD-DFT under similar computational constraints but using only scalar XC potential and energy density functional dependent on the electronic charge-density alone. The CDFT based approach yields TD exchange- and correlation energy and TD electronic charge-density significantly different from that obtained using the conventional TD-DFT based approach, particularly, at typical magnetic field strengths and during a typical time period of the TD field. This peculiar behavior of the CDFT-based approach is traced to the TD current-density dependent vector XC potential, which can induce nonadiabatic effects causing retardation of the oscillating electronic charge density. Such dissipative electron dynamics of the He 2++ molecular ion is elucidated by treating electronic charge density as an electron-"fluid" in the terminology of QFD. Copyright © 2011 Wiley Periodicals, Inc.

  6. Current state of methodological and decisions for radiation treatment of blood, its components and products

    Directory of Open Access Journals (Sweden)

    Gordeev A.V.

    2014-12-01

    Full Text Available This article presents currently used blood transfusion media — components and blood products, therapeutic effects, reactions and complications of blood transfusion, use of radiation treatment for blood transfusion fluids. There had been discussed in detail the practice of radiation processing of blood components and for the prevention of reaction "graft versus host" and studies of plasma radiation treatment for its infectious safety. There was presented the current state of techniques and technical solutions of radiation treatment of transfusion-transmissible environments. There were also considered an alternative to radiation treatment of blood.

  7. Mindfulness-Based Stress Reduction and Transcendental Meditation: Current State of Research

    Directory of Open Access Journals (Sweden)

    Adam Holt

    2015-04-01

    Full Text Available This article summarizes the current state of meditation research, specifically focusing on mindfulness-based stress reduction and transcendental meditation. Despite significant methodological problems with the studies reported to date on the subject, there is consistent evidence that meditation can produce changes in the nervous system and physiology of the meditator, and can help with various psychological markers of well-being. Regarding improvement in specific clinical diseases, research is generally mixed and preliminary. Strong recommendations cannot be made based on current evidence, and further studies are needed. In general, there is a stronger body of evidence supporting mindfulness-based stress reduction than for transcendental meditation.

  8. Current State-of-the-Art MRI for Comprehensive Evaluation of Potential Living Liver Donors.

    Science.gov (United States)

    Jhaveri, Kartik S; Guo, Lijun; Guimarães, Luís

    2017-07-01

    This review focuses on the role of state-of-the-art MRI-based techniques for comprehensive evaluation of living donors providing single-visit assessment of the liver vasculature via MR angiography, of the biliary tract via conventional T2-weighted MR cholangiography and T1-weighted gadoxetate disodium-enhanced MR cholangiography, and of hepatic steatosis via T2*-corrected multiecho chemical shift-based water-fat separation MRI and high-speed T2-corrected multiecho MR spectroscopy. By using current state-of-the-art techniques, MRI can provide a one-stop-shop method for evaluation of the potential living liver donors.

  9. CURRENT STATE AND DEVELOPMENT OF THE FISHERIES SECTOR OF UKRAINE IN THE CRISIS

    Directory of Open Access Journals (Sweden)

    І. Hrytsyniak

    2015-03-01

    Full Text Available Purpose. Fisheries has a strategic importance for supplying the population with food, while the sectors of the national economy with raw materials, for strengthening the country’s position in the international arena, for preserving spatial and national integrity of Ukraine, plays an important role in the restoration of natural resources and in the increase in employment. In recent years, fisheries sector of Ukraine is in a severe, protracted economic crisis. Considering its socio-economic and strategic importance for the state, there is a task for developing an effective policy for fisheries development in Ukraine that defines the relevance of the research and practical importance of its results. Thus, a compilation and analysis of the existing information on the current state and development of fisheries sector in the crisis period will allow a deeper understanding of problems in the fisheries sector in Ukraine and finding quick solutions. The main goal of the state policy in the field of fisheries in Ukraine has to be meeting the needs of the population in fish and fish products by creating conditions for effective operations and development of aquaculture and fishing enterprises. Findings. The article reviews the current state of the development of fisheries sector in Ukraine, consumption, catch, processing of fish and seafood, dynamics of fish product exports and imports, legislative and regulatory framework of fisheries sector, state of the implementation of WTO and EU requirements, as well as finding ways for the fisheries sector out from the crisis. Originality. This work is a compilation of the information on the current state of fisheries sector development in Ukraine. The information is provided in the form of a coherent presentation of information on the current state of fisheries sector in Ukraine, both in the domestic and foreign markets. Practical Value. The fact that the fisheries sector of Ukraine is still in a depressive state

  10. CURRENT STATE OF WATER BIORESOURCES OF THE VOLGA AND CASPIAN SEA BASIN

    Directory of Open Access Journals (Sweden)

    L. M. Vasileva

    2012-01-01

    Full Text Available The article considers the issues of current degraded state of aquatic biological resources of the Volga-Caspian Sea basin and provides specific data on commercial stocks of fish. The main reasons for decrease in natural stocks of ichthyofauna are regulation and pollution of the spawning rivers, adverse hydrological conditions, injudicious hunting, poaching pressure. To improve the state of natural stocks of fish it is necessary to increase their reproduction and implement measures to restore and rational exploitation of aquatic bioresources of the Volga- Caspian Sea basin.

  11. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity

    Science.gov (United States)

    Ellinwood, Nicholas; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

    2017-09-01

    The KV1.5 potassium channel, which underlies the ultra-rapid delayed-rectifier current (IKur) and is predominantly expressed in atria vs. ventricles, has emerged as a promising target to treat atrial fibrillation (AF). However, while numerous KV1.5-selective compounds have been screened, characterized, and tested in various animal models of AF, evidence of antiarrhythmic efficacy in humans is still lacking. Moreover, current guidelines for pre-clinical assessment of candidate drugs heavily rely on steady-state concentration-response curves or IC50 values, which can overlook adverse cardiotoxic effects. We sought to investigate the effects of kinetics and state-dependent binding of IKur-targeting drugs on atrial electrophysiology in silico and reveal the ideal properties of IKur blockers that maximize anti-AF efficacy and minimize pro-arrhythmic risk. To this aim, we developed a new Markov model of IKur that describes KV1.5 gating based on experimental voltage-clamp data in atrial myocytes from patient right-atrial samples in normal sinus rhythm. We extended the IKur formulation to account for state-specificity and kinetics of KV1.5-drug interactions and incorporated it into our human atrial cell model. We simulated 1- and 3-Hz pacing protocols in drug-free conditions and with a [drug] equal to the IC50 value. The effects of binding and unbinding kinetics were determined by examining permutations of the forward (kon) and reverse (koff) binding rates to the closed, open, and inactivated states of the KV1.5 channel. We identified a subset of ideal drugs exhibiting anti-AF electrophysiological parameter changes at fast pacing rates (effective refractory period prolongation), while having little effect on normal sinus rhythm (limited action potential prolongation). Our results highlight that accurately accounting for channel interactions with drugs, including kinetics and state-dependent binding, is critical for developing safer and more effective pharmacological anti

  12. Characterization of Final State Interaction Strength in Plastic Scintillator by Muon-Neutrino Charged Current Charged Pion Production

    Energy Technology Data Exchange (ETDEWEB)

    Eberly, Brandon M. [Univ. of Pittsburgh, PA (United States)

    2014-01-01

    Precise knowledge of neutrino-nucleus interactions is increasingly important as neutrino oscillation measurements transition into the systematics-limited era. In addition to modifying the initial interaction, the nuclear medium can scatter and absorb the interaction by-products through final state interactions, changing the types and kinematic distributions of particles seen by the detector. Recent neutrino pion production data from MiniBooNE is inconsistent with the final state interaction strength predicted by models and theoretical calculations, and some models fit best to the MiniBooNE data only after removing final state interactions entirely. This thesis presents a measurement of dσ/dTπ and dσ/dθπ for muon-neutrino charged current charged pion production in the MINER A scintillator tracker. MINER A is a neutrino-nucleus scattering experiment installed in the few-GeV NuMI beam line at Fermilab. The analysis is limited to neutrino energies between 1.5-10 GeV. Dependence on invariant hadronic mass W is studied through two versions of the analysis that impose the limits W < 1.4 GeV and W < 1.8 GeV. The lower limit on W increases compatibility with the MiniBooNE pion data. The shapes of the differential cross sections, which depend strongly on the nature of final state interactions, are compared to Monte Carlo and theoretical predictions. It is shown that the measurements presented in this thesis favor models that contain final state interactions. Additionally, a variety of neutrino-nucleus interaction models are shown to successfully reproduce the thesis measurements, while simultaneously failing to describe the shape of the MiniBooNE data.

  13. Temperature dependent current transport properties in Cu{sub 2}ZnSnS{sub 4} solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Danilson, Mati, E-mail: mati.danilson@ttu.ee [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Kask, Erkki, E-mail: erkki.kask@ttu.ee [Department of Physics, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Pokharel, Nikhil, E-mail: pokharel.nikhil@gmail.com [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Department of Natural Sciences (Physics), Kathmandu University, PO Box 6250 Dhulikhel (Nepal); Grossberg, Maarja, E-mail: Maarja.Grossberg@ttu.ee [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Kauk-Kuusik, Marit, E-mail: marit.kauk-kuusik@ttu.ee [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Varema, Tiit, E-mail: Tiit.Varema@ttu.ee [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Krustok, Jüri, E-mail: juri.krustok@ttu.ee [Department of Materials Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia); Department of Physics, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn (Estonia)

    2015-05-01

    Quaternary semiconductor compound Cu{sub 2}ZnSnS{sub 4} (CZTS) is a promising non-toxic absorber material for solar cells made from earth abundant elements. In this study temperature dependencies (T = 10-300 K) of current-voltage (J-V) characteristics and external quantum efficiency (EQE) spectra of CZTS monograin layer solar cells were measured in order to clarify current transport in CZTS that is still not fully understood. Three different temperature ranges can be distinguished from the temperature dependence of the series resistance (R{sub s}) obtained from J-V measurements and the effective bandgap energy (E{sub g}{sup ⁎}) determined from the EQE spectra. Thermally activated conductivity, Mott's variable-range hopping conductivity, and very low temperature (< 40 K) blocking of the interface recombination were observed. - Highlights: • Cu{sub 2}ZnSnS{sub 4} monograin layer solar cell temperature dependent parameters were studied. • Thermally activated conductivity at temperatures T > 90 K • Mott's variable-range hopping conductivity at temperatures T = 90-40 K • Very low temperature (< 40 K) blocking of interface recombination was observed.

  14. Transport spin dependent in nanostructures: Current and geometry effect of quantum dots in presence of spin-orbit interaction

    Science.gov (United States)

    Paredes-Gutiérrez, H.; Pérez-Merchancano, S. T.; Beltran-Rios, C. L.

    2017-12-01

    In this work, we study the quantum electron transport through a Quantum Dots Structure (QDs), with different geometries, embedded in a Quantum Well (QW). The behaviour of the current through the nanostructure (dot and well) is studied considering the orbital spin coupling of the electrons and the Rashba effect, by means of the second quantization theory and the standard model of Green’s functions. Our results show the behaviour of the current in the quantum system as a function of the electric field, presenting resonant states for specific values of both the external field and the spin polarization. Similarly, the behaviour of the current on the nanostructure changes when the geometry of the QD and the size of the same are modified as a function of the polarization of the electron spin and the potential of quantum confinement.

  15. THE CURRENT STATE OF LEGAL INSTITUTIONS PROTECTING THE RIGHTS OF JUVENILES IN RUSSIA

    OpenAIRE

    Yulia Hafizovna DAVYDOVA

    2015-01-01

    The article highlights the current state of the legislation on protection of the rights of under-aged. Much attention is paid to the formation of the juvenile justice system in the Russian Federation. We present problems related to law infringements by teenagers in various fields and their solutions, highlight the work and the development of juvenile courts in Russia, sum up the results of the implementation of juvenile technologies and their significance, gives the definition of the term «co...

  16. The Current State and TRL Assessment of Unattended and Left-Behind Object Detection Technology

    Science.gov (United States)

    2014-09-01

    Gagnon, Dr. Marc Lalonde , Computer Research Institute of Montreal (CRIM) The feedback from project partners: RCMP, TC, CATSA, DRDC, UK HomeOffice, FBI...The urrent tate and TRL ssessment of nattended and eft-ehind bject etection echnology Prepared by: M. Lalonde ,M...TR) July 2014 The Current State and TRL Assessment of Unattended and Left-Behind Object Detection Technology M. Lalonde , M. Derenne, L. Gagnon, D

  17. Localized excitations in nonlinear complex systems current state of the art and future perspectives

    CERN Document Server

    Cuevas-Maraver, Jesús; Frantzeskakis, Dimitri; Karachalios, Nikos; Kevrekidis, Panayotis; Palmero-Acebedo, Faustino

    2014-01-01

    The study of nonlinear localized excitations is a long-standing challenge for research in basic and applied science, as well as engineering, due to their importance in understanding and predicting phenomena arising in nonlinear and complex systems, but also due to their potential for the development and design of novel applications. This volume is a compilation of chapters representing the current state-of-the-art on the field of localized excitations and their role in the dynamics of complex physical systems.

  18. Current State and Issues of Logistics Cost Accounting and Management in Malaysia

    OpenAIRE

    Zakariah, Sahidah; Pyeman, Jaafar

    2013-01-01

    Background: Logistics cost is an important factor affecting the competitiveness on both macro (national) and micro level (firms). Logistics cost indicates the performance of logistics industry, efficiency level and its competitiveness. Research Problem: Despite of its significance, current state of logistics cost accounting and management in Malaysia has not properly addressed and the issues surround logistics cost measurement remains incoherent. Aim of research: The purpose o...

  19. Current state and near-term prospects for development of the transport logistics market in Ukraine

    Directory of Open Access Journals (Sweden)

    Olena Karpenko

    2017-05-01

    Full Text Available The article has studied the current state of the transport services market in Ukraine, characterized features of the favorable geopolitical position of the country, identified segments of the market of transport and logistics services in Ukraine, made an analysis of the dynamics of freight transportation by land transport, determined its capacity in money terms and calculated the component share of this type of activity in the country’s GDP.

  20. The Current State and Future Development of MOT Education for Semiconductor Engineers

    Science.gov (United States)

    Imamura, Yoichi; Hashizume, Tsuneo; Uno, Tadashi

    In this paper, the results of a preliminary survey on MOT conducted by a questionnaire are described so as to better deploy MOT education for SoC development engineers working for client companies of a consortium company established by eleven major Japanese semiconductor manufacturers. An overview of assessments of MOT is given, and the current state of MOT education supported by the consortium is documented, and a specific deployment plan is suggested.

  1. Glucoamylases production of Aspergillus niger in solid state fermentation using a continuous counter-current reactor

    OpenAIRE

    Varzakas, T. H.; Roussos, Sevastianos; Arvanitoyannis, I. S.

    2008-01-01

    This work presents the continuous production of fungal biomass and glucoamylase by solid state fermentation (SSF) in a counter-current reactor adapted for this purpose. Pre-germinated conidia of Aspergillus niger were used as an inoculum, and sugarcane bagasse, embedded with a nutritive solution, was the solid support. The solids residence time distribution (RTD) was carried out by feeding one impule of blue-coloured humidified bagasse and its RTD was fixed at 20 h. This study demonstrated th...

  2. Forskolin suppresses delayed-rectifier K+ currents and enhances spike frequency-dependent adaptation of sympathetic neurons.

    Directory of Open Access Journals (Sweden)

    Luis I Angel-Chavez

    Full Text Available In signal transduction research natural or synthetic molecules are commonly used to target a great variety of signaling proteins. For instance, forskolin, a diterpene activator of adenylate cyclase, has been widely used in cellular preparations to increase the intracellular cAMP level. However, it has been shown that forskolin directly inhibits some cloned K+ channels, which in excitable cells set up the resting membrane potential, the shape of action potential and regulate repetitive firing. Despite the growing evidence indicating that K+ channels are blocked by forskolin, there are no studies yet assessing the impact of this mechanism of action on neuron excitability and firing patterns. In sympathetic neurons, we find that forskolin and its derivative 1,9-Dideoxyforskolin, reversibly suppress the delayed rectifier K+ current (IKV. Besides, forskolin reduced the spike afterhyperpolarization and enhanced the spike frequency-dependent adaptation. Given that IKV is mostly generated by Kv2.1 channels, HEK-293 cells were transfected with cDNA encoding for the Kv2.1 α subunit, to characterize the mechanism of forskolin action. Both drugs reversible suppressed the Kv2.1-mediated K+ currents. Forskolin inhibited Kv2.1 currents and IKV with an IC50 of ~32 μM and ~24 µM, respectively. Besides, the drug induced an apparent current inactivation and slowed-down current deactivation. We suggest that forskolin reduces the excitability of sympathetic neurons by enhancing the spike frequency-dependent adaptation, partially through a direct block of their native Kv2.1 channels.

  3. Current and potential sustainable corn stover feedstock for biofuel production in the United States

    Science.gov (United States)

    Tan, Zhengxi; Liu, Shu-Guang; Tieszen, Larry L.; Bliss, Norman

    2012-01-01

    Increased demand for corn (Zea mays L.) stover as a feedstock for cellulosic ethanol raises concerns about agricultural sustainability. Excessive corn stover harvesting could have long-term impacts on soil quality. We estimated current and future stover production and evaluated the potential harvestable stover amount (HSA) that could be used for biofuel feedstock in the United States by defining the minimum stover requirement (MSR) associated with the current soil organic carbon (SOC) content, tillage practices, and crop rotation systems. Here we show that the magnitude of the current HSA is limited (31 Tg y−1, dry matter) due to the high MSR for maintaining the current SOC content levels of soils that have a high carbon content. An alternative definition of MSR for soils with a moderate level of SOC content could significantly elevate the annual HSA to 68.7 Tg, or even to 132.2 Tg if the amount of currently applied manure is counted to partially offset the MSR. In the future, a greater potential for stover feedstock could come from an increase in stover yield, areal harvest index, and/or the total planted area. These results suggest that further field experiments on MSR should be designed to identify differences in MSR magnitude between maintaining SOC content and preventing soil erosion, and to understand the role of current SOC content level in determining MSR from soils with a wide range of carbon contents and climatic conditions.

  4. Mixed states in bipolar disorder - changes in DSM-5 and current treatment recommendations.

    Science.gov (United States)

    Betzler, Felix; Stöver, Laura Apollonia; Sterzer, Philipp; Köhler, Stephan

    2017-11-01

    Mixed states in affective disorders represent a particular challenge in clinical routine, characterized by a complicated course of treatment and a worse treatment response. Clinical features of mixed states and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria are presented and critical discussed. We then performed a systematic review using the terms 'bipolar', 'mixed' and 'randomized' to evaluate current treatment options. For pharmacological treatment of mixed states in total, there is still insufficient data from RCTs. However, there is some evidence for efficacy in mixed states from RCTs for atypical antipsychotics, especially olanzapine, aripiprazole and asenapine as well as mood stabilizers as valproate and carbamazepine. Mixed states are of a high clinical relevance and the DSM-5 criteria substantially reduced the diagnostic threshold. Besides advantages of a better characterization of patients with former DSM-IV-defined mixed episodes, disadvantages arise for example differential diagnoses with a substantial overlap in symptoms such as borderline personality disorders. Atypical antipsychotics, valproate and carbamazepine demonstrated efficacy in a limited sample of RCTs. The number of RCTs in the treatment of mixed states is highly limited. Furthermore, nearly all studies were funded by pharmaceutical companies which may lead to an underestimation of classical mood stabilizers such as lithium.

  5. SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors.

    Science.gov (United States)

    Norton, Jeffrey A; Kim, Teresa; Kim, Joseph; McCarter, Martin D; Kelly, Kaitlyn J; Wong, Joyce; Sicklick, Jason K

    2018-01-01

    The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery. Martin D. McCarter, MD of the University of Colorado discussed the current management of gastric gastrointestinal stromal tumors (GIST). Kaitlyn J. Kelly, MD of the University of California, San Diego discussed the management of gastric carcinoid tumors. Jeffrey A. Norton of Stanford University discussed recent advances in the management of gastric adenocarcinoma including a focus on hereditary diffuse gastric cancer (HDGC). Joseph Kim, MD of Stony Brook University discussed a systematic approach to minimally invasive gastrectomy for cancer. Joyce Wong, MD of Pennsylvania State University discussed the role for cytoreductive surgery (CRS) and HIPEC for gastric adenocarcinoma. This review provides gastrointestinal surgeons with a concise update on the current surgical management of gastric tumors.

  6. Functional connectivity analysis of resting-state fMRI networks in nicotine dependent patients

    Science.gov (United States)

    Smith, Aria; Ehtemami, Anahid; Fratte, Daniel; Meyer-Baese, Anke; Zavala-Romero, Olmo; Goudriaan, Anna E.; Schmaal, Lianne; Schulte, Mieke H. J.

    2016-03-01

    Brain imaging studies identified brain networks that play a key role in nicotine dependence-related behavior. Functional connectivity of the brain is dynamic; it changes over time due to different causes such as learning, or quitting a habit. Functional connectivity analysis is useful in discovering and comparing patterns between functional magnetic resonance imaging (fMRI) scans of patients' brains. In the resting state, the patient is asked to remain calm and not do any task to minimize the contribution of external stimuli. The study of resting-state fMRI networks have shown functionally connected brain regions that have a high level of activity during this state. In this project, we are interested in the relationship between these functionally connected brain regions to identify nicotine dependent patients, who underwent a smoking cessation treatment. Our approach is on the comparison of the set of connections between the fMRI scans before and after treatment. We applied support vector machines, a machine learning technique, to classify patients based on receiving the treatment or the placebo. Using the functional connectivity (CONN) toolbox, we were able to form a correlation matrix based on the functional connectivity between different regions of the brain. The experimental results show that there is inadequate predictive information to classify nicotine dependent patients using the SVM classifier. We propose other classification methods be explored to better classify the nicotine dependent patients.

  7. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Bers, A.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma

  8. System and method for generating steady state confining current for a toroidal plasma fusion reactor

    International Nuclear Information System (INIS)

    Fisch, N.J.

    1981-01-01

    A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave rf energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected rf energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected rf energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range delta . The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width delta in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma

  9. Uncovering state-dependent relationships in shallow lakes using Bayesian latent variable regression.

    Science.gov (United States)

    Vitense, Kelsey; Hanson, Mark A; Herwig, Brian R; Zimmer, Kyle D; Fieberg, John

    2018-03-01

    Ecosystems sometimes undergo dramatic shifts between contrasting regimes. Shallow lakes, for instance, can transition between two alternative stable states: a clear state dominated by submerged aquatic vegetation and a turbid state dominated by phytoplankton. Theoretical models suggest that critical nutrient thresholds differentiate three lake types: highly resilient clear lakes, lakes that may switch between clear and turbid states following perturbations, and highly resilient turbid lakes. For effective and efficient management of shallow lakes and other systems, managers need tools to identify critical thresholds and state-dependent relationships between driving variables and key system features. Using shallow lakes as a model system for which alternative stable states have been demonstrated, we developed an integrated framework using Bayesian latent variable regression (BLR) to classify lake states, identify critical total phosphorus (TP) thresholds, and estimate steady state relationships between TP and chlorophyll a (chl a) using cross-sectional data. We evaluated the method using data simulated from a stochastic differential equation model and compared its performance to k-means clustering with regression (KMR). We also applied the framework to data comprising 130 shallow lakes. For simulated data sets, BLR had high state classification rates (median/mean accuracy >97%) and accurately estimated TP thresholds and state-dependent TP-chl a relationships. Classification and estimation improved with increasing sample size and decreasing noise levels. Compared to KMR, BLR had higher classification rates and better approximated the TP-chl a steady state relationships and TP thresholds. We fit the BLR model to three different years of empirical shallow lake data, and managers can use the estimated bifurcation diagrams to prioritize lakes for management according to their proximity to thresholds and chance of successful rehabilitation. Our model improves upon

  10. Remarks on the necessity and implications of state-dependence in the black hole interior

    CERN Document Server

    Papadodimas, Kyriakos

    2016-01-01

    We revisit the "state-dependence" of the map that we proposed recently between bulk operators in the interior of a large AdS black hole and operators in the boundary CFT. By refining recent versions of the information paradox, we show that this feature is necessary for the CFT to successfully describe local physics behind the horizon --- not only for single-sided black holes but even in the eternal black hole. We show that state-dependence is invisible to an infalling observer who cannot differentiate these operators from those of ordinary quantum effective field theory. Therefore the infalling observer does not observe any violations of quantum mechanics. We successfully resolve a large class of potential ambiguities in our construction. We analyze states where the CFT is entangled with another system and show that the ER=EPR conjecture emerges from our construction in a natural and precise form. We comment on the possible semi-classical origins of state-dependence.

  11. Effects of sleep deprivation on memory in mice: role of state-dependent learning.

    Science.gov (United States)

    Patti, Camilla L; Zanin, Karina A; Sanday, Leandro; Kameda, Sonia R; Fernandes-Santos, Luciano; Fernandes, Helaine A; Andersen, Monica L; Tufik, Sergio; Frussa-Filho, Roberto

    2010-12-01

    A considerable amount of experimental evidence suggests that sleep plays a critical role in learning/memory processes. In addition to paradoxical sleep, slow wave sleep is also reported to be involved in the consolidation process of memories. Additionally, sleep deprivation can induce other behavioral modifications, such as emotionality and alternations in locomotor activity in rodents. These sleep deprivation-induced alterations in the behavioral state of animals could produce state-dependent learning and contribute, at least in part, to the amnestic effects of sleep deprivation. The aim of the present study was to examine the participation of state-dependent learning during memory impairment induced by either paradoxical sleep deprivation (PSD) or total sleep deprivation (TSD) in mice submitted to the plus-maze discriminative avoidance or to the passive avoidance task. Paradoxical sleep deprivation (by the multiple platform method) and total sleep deprivation (by the gentle handling method) were applied to animals before training and/or testing. Whereas pre-training or pre-test PSD impaired retrieval in both memory models, pre-training plus pre-test PSD counteracted this impairment. For TSD, pre-training, pre-test, and pre-training plus pre-test TSD impaired retrieval in both models. Our data demonstrate that PSD- (but not TSD-) memory deficits are critically related to state-dependent learning.

  12. Affective state-dependent changes in the brain functional network in major depressive disorder.

    Science.gov (United States)

    Park, Chang-hyun; Wang, Sheng-Min; Lee, Hae-Kook; Kweon, Yong-Sil; Lee, Chung Tai; Kim, Ki-Tae; Kim, Young-Joo; Lee, Kyoung-Uk

    2014-09-01

    In major depressive disorder (MDD), as a network-level disease, the pathophysiology would be displayed to a wide extent over the brain. Moreover, the network-wide changes could be dependent on the context of affective processing. In this study, we sought affective state-dependent changes of the brain functional network by applying a graph-theoretical approach to functional magnetic resonance imaging data acquired in 13 patients with MDD and 12 healthy controls who were exposed to video clips inducing the negative, neutral or positive affective state. For each affective condition, a group-wise brain functional network was constructed based on partial correlation of mean activity across subjects between brain areas. Network parameters, global and local efficiencies, were measured from the brain functional network. Compared with controls', patients' brain functional network shifted to the regular network in the topological architecture, showing decreased global efficiency and increased local efficiency, during negative and neutral affective processing. Further, the shift to the regular network in patients was most evident during negative affective processing. MDD is proposed to provoke widespread changes across the whole brain in an affective state-dependent manner, specifically in the negative affective state. © The Author (2013). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  13. State-dependent differential Riccati equation to track control of time-varying systems with state and control nonlinearities.

    Science.gov (United States)

    Korayem, M H; Nekoo, S R

    2015-07-01

    This work studies an optimal control problem using the state-dependent Riccati equation (SDRE) in differential form to track for time-varying systems with state and control nonlinearities. The trajectory tracking structure provides two nonlinear differential equations: the state-dependent differential Riccati equation (SDDRE) and the feed-forward differential equation. The independence of the governing equations and stability of the controller are proven along the trajectory using the Lyapunov approach. Backward integration (BI) is capable of solving the equations as a numerical solution; however, the forward solution methods require the closed-form solution to fulfill the task. A closed-form solution is introduced for SDDRE, but the feed-forward differential equation has not yet been obtained. Different ways of solving the problem are expressed and analyzed. These include BI, closed-form solution with corrective assumption, approximate solution, and forward integration. Application of the tracking problem is investigated to control robotic manipulators possessing rigid or flexible joints. The intention is to release a general program for automatic implementation of an SDDRE controller for any manipulator that obeys the Denavit-Hartenberg (D-H) principle when only D-H parameters are received as input data. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Visualizing the mechanism that determines the critical current density in polycrystalline superconductors using time-dependent Ginzburg-Landau theory

    Science.gov (United States)

    Carty, George J.; Hampshire, Damian P.

    2008-05-01

    In polycrystalline superconducting materials optimized for high critical current density (JC) in high magnetic fields, the mechanism that determines JC has long remained uncertain because of the complicated manner in which the fluxon-fluxon and fluxon-microstructure forces combine. In this work, the time-dependent Ginzburg-Landau equations are used to produce visualizations of fluxons at JC that show the disorder in the pinned part of the flux-line lattice and the motion of those fluxons along grain boundaries that cause dissipation. Calculated values of JC are consistent with experimental data.

  15. Measurement of the Energy Dependent Numu Charged Current Inclusive Cross Section on Iron with the T2K INGRID Detector

    Science.gov (United States)

    Suzuki, Kento

    The Tokai-to-Kamioka (T2K) experiment is designed to measure neutrino oscillation parameters. INGRID is installed 280 m downstream from the T2K target to monitor the direction and intensity of the neutrino beam. It has 14 independent modules which are composed of iron plates and scintillator planes. The purpose of this analysis is to measure the energy dependent muon neutrino charged current inclusive cross section on iron. We estimate the sensitivity of the measurement using toy MC data and the expected error size is 11.5-13.8%.

  16. Multiobjective Output Feedback Control of a Class of Stochastic Hybrid Systems with State-Dependent Noise

    Directory of Open Access Journals (Sweden)

    S. Aberkane

    2007-01-01

    Full Text Available This paper deals with dynamic output feedback control of continuous-time active fault tolerant control systems with Markovian parameters (AFTCSMP and state-dependent noise. The main contribution is to formulate conditions for multiperformance design, related to this class of stochastic hybrid systems, that take into account the problematic resulting from the fact that the controller only depends on the fault detection and isolation (FDI process. The specifications and objectives under consideration include stochastic stability, ℋ2 and ℋ∞ (or more generally, stochastic integral quadratic constraints performances. Results are formulated as matrix inequalities. The theoretical results are illustrated using a classical example from literature.

  17. Equation of states and melting temperatures of diamond cubic and zincblende semiconductors: pressure dependence

    Energy Technology Data Exchange (ETDEWEB)

    Hung, V V; Hanh, P T M [Hanoi National Pedagogic University, Km8 Hanoi-Sontay Highway, Hanoi (Viet Nam); Masuda-Jindo, K [Department of Material Science and Engineering, Tokyo Institute of Technology, Nagasuta, Midori-ku, Yokohama 226-8503 (Japan); Hai, N T [Hanoi University of Technology, 01 Dai Co Viet Road, Hanoi (Viet Nam)], E-mail: kmjindo@issp.u-tokyo.ac.jp

    2008-02-15

    The pressure dependence of the melting temperatures of tetrahedrally coordinated semiconductors are studied using the equation of states derived from the statistical moment method, in comparison with those of the normal metals. Using the general expressions of the limiting temperatures T{sub m}, we calculate the 'melting' temperatures of the semiconductor crystals and normal metals as a function of the hydrostatic pressure. The physical origins for the inverse pressure dependence of T{sub m} observed for tetrahedrally coordinated semiconductors are also discussed.

  18. Polarization-state-dependent attenuation and amplification in a columnar thin film

    Science.gov (United States)

    Mackay, Tom G.; Lakhtakia, Akhlesh

    2017-12-01

    We numerically investigated the plane-wave reflection-transmission characteristics of a columnar thin film (CTF) whose columns are made from a dissipative material but whose void regions are filled with an active material. By computing the reflectances and transmittances, we found that the CTF can simultaneously amplify s-polarized incident light and attenuate p-polarized incident light, or vice versa. This polarization-state-dependent attenuation and amplification phenomenon depends upon the angle of incidence and the thickness of the CTF.

  19. The current state and trends of the development of universities in Ukraine

    Directory of Open Access Journals (Sweden)

    O.B. Morhulets

    2015-09-01

    Full Text Available Education is the basis of social, political, economic, spiritual, and cultural development. Therefore, the study of the current state and trends of the development of Ukrainian universities is a significant factor of social and economic progress of the country.The paper reflects the general state of universities in Ukraine, in particular, the trends in dynamics: the number of students in terms of entry/graduation, sources of financing, education fields; the number of universities in the context of accreditation, types and forms of ownership; the number of outbound Ukrainian and inbound foreign students; quantitative and qualitative characteristics of teaching staff; spending on higher education and the cost of funding per student compared with other countries. The purpose of the study is the assessment of economic activity of higher educational establishments in Ukraine, the identification of problems and tendencies of their development in the context of national transformational processes in education and formation of the society of knowledge. The methodical base used in the study is analysis and synthesis, methods of comparison and generalization, extrapolation, index and graphical methods. The practical value of the study is based on the results of a thorough analysis of university activities. Such results reveal the current state and trends of the development of universities under conditions of higher education transformation in Ukraine and its integration into the European educational area. The results of research improve understanding of the state and problems of the universities and provide the foundations for further research in the field of the national education system development and for improving of the quality of young professionals’ training. The trends of the university development indicate that the reorganization of higher education which is being currently taken place, already results in the emergence of new competencies of

  20. Stochastic macromodel of magnetic tunnel junction resistance variation and critical current dependence on resistance variation for SPICE simulation

    Science.gov (United States)

    Choi, Juntae; Song, Yunheub

    2017-04-01

    The resistance distribution of a magnetic tunnel junction (MTJ) shows nonuniformity according to various MTJ parameters. Moreover, this resistance variation leads to write-current density variation, which can cause serious problems when designing peripheral circuits for spin transfer torque magnetoresistance random access memory (STT-MRAM) and commercializing gigabit STT-MRAM. Therefore, a macromodel of MTJ including resistance, tunneling magnetoresistance ratio (TMR), and critical current variations is required for circuit designers to design MRAM peripheral circuits, that can overcome the various effects of the variations, such as write failure and read failure, and realize STT-MRAM. In this study, we investigated a stochastic behavior macromodel of the write current dependence on the MTJ resistance variation. The proposed model can possibly be used to analyze the write current density in relation to the resistance and TMR variations of MTJ with various parameter variations. It can be very helpful for designing STT-MRAM circuits and simulating the operation of STT-MRAM devices considering MTJ variations.

  1. Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives.

    Science.gov (United States)

    Lohr, Benedikt; Fingerle, Volker; Norris, Douglas E; Hunfeld, Klaus-Peter

    2018-04-02

    This review is directed at physicians and laboratory personnel in private practice and clinics who treat and diagnose Lyme borreliosis (LB) in patients as part of their daily work. A major objective of this paper is to bring together background information on Borrelia (B.) burgdorferi sensu lato (s.l.) and basic clinical knowledge of LB, which is one of the most frequently reported vector-borne diseases in the Northern Hemisphere. The goal is to provide practical guidance for clinicians and for laboratory physicians, and scientists for a better understanding of current achievements and ongoing obstacles in the laboratory diagnosis of LB, an infectious disease that still remains one of the diagnostic chameleons of modern clinical medicine. Moreover, in bringing together current scientific information from guidelines, reviews, and original papers, this review provides recommendations for selecting the appropriate tests in relation to the patient's stage of disease to achieve effective, stage-related application of current direct and indirect laboratory methods for the detection of B. burgdorferi s.l. Additionally, the review aims to discuss the current state of the art concerning the diagnostic potential and limitations of the assays and test methods currently in use to optimize LB patient management and provide insight into the possible future prospects of this rapidly changing area of laboratory medicine.

  2. Current drive studies for the ARIES steady-state tokamak reactors

    International Nuclear Information System (INIS)

    Mau, T.K.; Ehst, D.A.; Mandrekas, J.

    1994-01-01

    Steady-state plasma operating scenarios are designed for three versions of the ARIES reactor, using non-inductive current drive techniques that have an established database. R.f. waves, including fast and lower hybrid waves, are the reference drivers for the D-T burning ARIES-I and ARIES-II/IV, while neutral beam injection is employed for ARIES-III which burns D- 3 He. Plasma equilibria with a high bootstrap-current component have been used, in order to minimize the recirculating power fraction and cost of electricity. To maintain plasma stability, the driven current profile has been aligned with that of equilibrium by proper choices of the plasma profiles and power launch parameters. Except for ARIES-III, the current-drive power requirements and the relevant technology developments are found to be quite reasonable. The wave-power spectrum and launch requirements are also considered achievable with a modest development effort. Issues such as an improved database for fast-wave current drive, lower-hybrid power coupling to the plasma edge, profile control in the plasma core, and access to the design point of operation remain to be addressed. ((orig.))

  3. Exactly solvable quantum state reduction models with time-dependent coupling

    International Nuclear Information System (INIS)

    Brody, Dorje C; Constantinou, Irene C; Dear, James D C; Hughston, Lane P

    2006-01-01

    A closed-form solution to the energy-based stochastic Schroedinger equation with a time-dependent coupling is obtained. The solution is algebraic in character, and is expressed directly in terms of independent random data. The data consist of (i) a random variable H which has the distribution P(H=E i ) = π i , where π i is the transition probability vertical bar (ψ 0 vertical bar Φ i ) vertical bar 2 from the initial state vertical bar ψ 0 ) to the Lueders state vertical bar Φ i ) with energy E i , and (ii) an independent P-Brownian motion, where P is the physical probability measure associated with the dynamics of the reduction process. When the coupling is time independent, it is known that state reduction occurs asymptotically-that is to say, over an infinite time horizon. In the case of a time-dependent coupling, we show that if the magnitude of the coupling decreases sufficiently rapidly, then the energy variance will be reduced under the dynamics, but the state need not reach an energy eigenstate. This situation corresponds to the case of a 'partial' or 'incomplete' measurement of the energy. We also construct an example of a model where the opposite situation prevails, in which complete state reduction is achieved after the passage of a finite period of time

  4. Implications of the dependence of neuronal activity on neural network states for the design of brain-machine interfaces

    Directory of Open Access Journals (Sweden)

    Stefano ePanzeri

    2016-04-01

    Full Text Available Brain-machine interfaces (BMIs can improve the quality of life of patients with sensory and motor disabilities by both decoding motor intentions expressed by neural activity, and by encoding artificially sensed information into patterns of neural activity elicited by causal interventions on the neural tissue. Yet, current BMIs can exchange relatively small amounts of information with the brain. This problem has proved difficult to overcome by simply increasing the number of recording or stimulating electrodes, because trial-to-trial variability of neural activity partly arises from intrinsic factors (collectively known as the network state that include ongoing spontaneous activity and neuromodulation, and so is shared among neurons. Here we review recent progress in characterizing the state dependence of neural responses, and in particular of how neural responses depend on endogenous slow fluctuations of network excitability. We then elaborate on how this knowledge may be used to increase the amount of information that BMIs exchange with brains. Knowledge of network state can be used to fine-tune the stimulation pattern that should reliably elicit a target neural response used to encode information in the brain, and to discount part of the trial-by-trial variability of neural responses, so that they can be decoded more accurately.

  5. Dolphin changes in whistle structure with watercraft activity depends on their behavioral state.

    Science.gov (United States)

    May-Collado, Laura J; Quiñones-Lebrón, Shakira G

    2014-04-01

    Dolphins rely on whistles to identify each other and to receive and convey information about their environment. Although capable of adjusting these signals with changing environments, there is little information on how dolphins acoustically respond to different watercraft activities and if this response depends on dolphin behavioral state. Bottlenose dolphin whistles were recorded in the presence of research and dolphin-watching boats. Dolphins emitted lower frequency and longer whistles when interacting with dolphin-watching boats, particularly during foraging activities. This study suggests that dolphin-watching boat traffic significantly hinders dolphin communication during important behavioral states.

  6. Verification of Large State/Event Systems using Compositionality and Dependency Analysis

    DEFF Research Database (Denmark)

    Lind-Nielsen, Jørn; Andersen, Henrik Reif; Hulgaard, Henrik

    2001-01-01

    A state/event model is a concurrent version of Mealy machines used for describing embedded reactive systems. This paper introduces a technique that uses compositionality and dependency analysis to significantly improve the efficiency of symbolic model checking of state/event models. It makes...... possible automated verification of large industrial designs with the use of only modest resources (less than 5 minutes on a standard PC for a model with 1421 concurrent machines). The results of the paper are being implemented in the next version of the commercial tool visualSTATETM....

  7. Verification of Large State/Event Systems using Compositionality and Dependency Analysis

    DEFF Research Database (Denmark)

    Lind-Nielsen, Jørn; Andersen, Henrik Reif; Behrmann, Gerd

    1999-01-01

    A state/event model is a concurrent version of Mealy machines used for describing embedded reactive systems. This paper introduces a technique that uses \\emph{compositionality} and \\emph{dependency analysis} to significantly improve the efficiency of symbolic model checking of state/event models....... This technique makes possible automated verification of large industrial designs with the use of only modest resources (less than one hour on a standard PC for a model with 1421 concurrent machines). The results of the paper are being implemented in the next version of the commercial tool \\visualstate....

  8. Calculating Derivative Couplings between Time-Dependent Hartree-Fock Excited States with Pseudo-Wavefunctions.

    Science.gov (United States)

    Alguire, Ethan C; Ou, Qi; Subotnik, Joseph E

    2015-06-18

    A pseudo-wavefunction description of time-dependent Hartree-Fock (TDHF) states is proposed and used to develop an analytic expression for derivative couplings between TDHF excited states based on the Hellmann-Feynman theorem. The resulting expression includes Pulay terms associated with using an atom-centered basis as well as a correction to ensure translational invariance. We demonstrate that our formalism recovers the well-known Chernyak-Mukamel expression near a crossing and in the limit of a complete basis, and thus our approach is consistent with time-dependent response theory. In a companion paper (DOI 10.1021/jp5057682 ), we investigate these derivative couplings near conical intersections and show that they behave correctly.

  9. Periodic solution for state-dependent impulsive shunting inhibitory CNNs with time-varying delays.

    Science.gov (United States)

    Şaylı, Mustafa; Yılmaz, Enes

    2015-08-01

    In this paper, we consider existence and global exponential stability of periodic solution for state-dependent impulsive shunting inhibitory cellular neural networks with time-varying delays. By means of B-equivalence method, we reduce these state-dependent impulsive neural networks system to an equivalent fix time impulsive neural networks system. Further, by using Mawhin's continuation theorem of coincide degree theory and employing a suitable Lyapunov function some new sufficient conditions for existence and global exponential stability of periodic solution are obtained. Previous results are improved and extended. Finally, we give an illustrative example with numerical simulations to demonstrate the effectiveness of our theoretical results. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Local membrane deformations activate Ca2+-dependent K+ and anionic currents in intact human red blood cells.

    Directory of Open Access Journals (Sweden)

    Agnieszka Dyrda

    Full Text Available BACKGROUND: The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter. The shear stress induced by such flow, as well as the local membrane deformations generated in certain pathological conditions, such as sickle cell anemia, have been shown to increase membrane permeability, based largely on experimentation with red cell suspensions. We attempted here the first measurements of membrane currents activated by a local and controlled membrane deformation in single red blood cells under on-cell patch clamp to define the nature of the stretch-activated currents. METHODOLOGY/PRINCIPAL FINDINGS: The cell-attached configuration of the patch-clamp technique was used to allow recordings of single channel activity in intact red blood cells. Gigaohm seal formation was obtained with and without membrane deformation. Deformation was induced by the application of a negative pressure pulse of 10 mmHg for less than 5 s. Currents were only detected when the membrane was seen domed under negative pressure within the patch-pipette. K(+ and Cl(- currents were strictly dependent on the presence of Ca(2+. The Ca(2+-dependent currents were transient, with typical decay half-times of about 5-10 min, suggesting the spontaneous inactivation of a stretch-activated Ca(2+ permeability (PCa. These results indicate that local membrane deformations can transiently activate a Ca(2+ permeability pathway leading to increased [Ca(2+](i, secondary activation of Ca(2+-sensitive K(+ channels (Gardos channel, IK1, KCa3.1, and hyperpolarization-induced anion currents. CONCLUSIONS/SIGNIFICANCE: The stretch-activated transient PCa observed here under local membrane deformation is a likely contributor to the Ca(2+-mediated effects observed during the normal aging process of red blood cells, and

  11. Is current consumption excessive? A general framework and some indications for the United States.

    Science.gov (United States)

    Ehrlich, Paul R; Goulder, Lawrence H

    2007-10-01

    Many prior studies have explored the implications of human population growth and environmentally problematic technologies for biodiversity loss and other forms of environmental degradation. Relatively few, however, have examined the impacts of the level and composition of consumption. We offer a framework that shows how the level and composition of a society's total consumption relate to the uses of various forms of capital and to the sustainability of natural resources and human well-being. We relate the framework to two main approaches-top-down macro studies and bottom-up computer models-for measuring whether overall consumption in the United States satisfies a sustainability requirement. Existing top-down studies have shortcomings that bias their results toward optimism, and current computer simulation models, although strong on revealing biophysical outcomes, are limited in their ability to evaluate impacts on human well-being. Although some ambiguities arise in determining whether overall consumption in the United States is excessive, our conclusions regarding the composition of U.S. consumption are unambiguous. Distorted consumption patterns and associated production methods lead to excessively rapid natural resource depletion; greater conservation would yield gains to current and future generations that more than compensate for the sacrifices involved. Public policies that deal with the composition problem not only would help conserve natural resources and improve current welfare but also would reduce the costs of meeting the goal of sustainability.

  12. Status and current spent fuel storage practices in the United States

    International Nuclear Information System (INIS)

    Lake, W.H.

    1999-01-01

    Brief discussions are presented on the history and state of spent fuel generation by utilities that comprise the United States commercial nuclear power industry, the current situation regarding the Federal government's nuclear waste policy, and evolving spent fuel storage practices. These evolving spent fuel storage practices are the result of private sector initiatives, but appear to be influenced by various external factors. The paper is not intended to provide a comprehensive appraisal of the storage initiatives being conducted by the private sector. The focus, instead, is on the Federal government's role and activities related to spent fuel management. Although the Federal government has adopted a policy calling for deep geological disposal of spent fuel, the US Congress has recently begun to consider expanding that policy to include a centralized interim storage facility. In the absence of such an expanded policy, the Department of Energy has performed some preliminary activities that would expedite development of a centralized interim storage facility, if Congress were to enact such a policy. The Department's current activities with regard to developing a centralized interim storage facility, which are consistent with the current policy, are described in the paper. The paper also describes two important technical development activities that have been conducted by the Department of Energy to support improved efficiency in spent fuel management. The Department's activities regarding development of a burnup credit methodology, and a dry transfer system are summarized. (author)

  13. Current state and perspectives of producing biodiesel‐like compounds by biotechnology

    Science.gov (United States)

    Uthoff, Stefan; Bröker, Daniel; Steinbüchel, Alexander

    2009-01-01

    Summary The global demand for crude oil is expected to continue to rise in future while simultaneously oil production is currently reaching its peak. Subsequently, rising oil prices and their negative impacts on economy, together with an increased environmental awareness of our society, directed the focus also on the biotechnological production of fuels. Although a wide variety of such fuels has been suggested, only the production of ethanol and biodiesel has reached a certain economic feasibility and volume, yet. This review focuses on the current state and perspectives of biotechnological production of biodiesel‐like compounds. At present by far most of the produced biodiesel is obtained by chemical transesterification reactions, which cannot meet the demands of a totally ‘green’ fuel production. Therefore, also several biotechnological biodiesel production processes are currently being developed. Biotechnological production can be achieved by purified enzymes in the soluble state, which requires cost‐intensive protein preparation. Alternatively, enzymes could be immobilized on an appropriate matrix, enabling a reuse of the enzyme, although the formation of by‐products may provide difficulties to maintain the enzyme activity. Processes in presence of organic solvents like t‐butanol have been developed, which enhance by‐product solubility and therefore prevent loss of enzyme activity. As another approach the application of whole‐cell catalysis for the production of fatty acid ethyl esters, which is also referred to as ‘microdiesel’, by recombinant microorganisms has recently been suggested. PMID:21255288

  14. Current state and perspectives of producing biodiesel-like compounds by biotechnology.

    Science.gov (United States)

    Uthoff, Stefan; Bröker, Daniel; Steinbüchel, Alexander

    2009-09-01

    The global demand for crude oil is expected to continue to rise in future while simultaneously oil production is currently reaching its peak. Subsequently, rising oil prices and their negative impacts on economy, together with an increased environmental awareness of our society, directed the focus also on the biotechnological production of fuels. Although a wide variety of such fuels has been suggested, only the production of ethanol and biodiesel has reached a certain economic feasibility and volume, yet. This review focuses on the current state and perspectives of biotechnological production of biodiesel-like compounds. At present by far most of the produced biodiesel is obtained by chemical transesterification reactions, which cannot meet the demands of a totally 'green' fuel production. Therefore, also several biotechnological biodiesel production processes are currently being developed. Biotechnological production can be achieved by purified enzymes in the soluble state, which requires cost-intensive protein preparation. Alternatively, enzymes could be immobilized on an appropriate matrix, enabling a reuse of the enzyme, although the formation of by-products may provide difficulties to maintain the enzyme activity. Processes in presence of organic solvents like t-butanol have been developed, which enhance by-product solubility and therefore prevent loss of enzyme activity. As another approach the application of whole-cell catalysis for the production of fatty acid ethyl esters, which is also referred to as 'microdiesel', by recombinant microorganisms has recently been suggested. © 2009 The Authors. Journal compilation © 2009 Society for Applied Microbiology and Blackwell Publishing Ltd.

  15. Current reversals and metastable states in the infinite Bose-Hubbard chain with local particle loss

    Science.gov (United States)

    Kiefer-Emmanouilidis, M.; Sirker, J.

    2017-12-01

    We present an algorithm which combines the quantum trajectory approach to open quantum systems with a density-matrix renormalization-group scheme for infinite one-dimensional lattice systems. We apply this method to investigate the long-time dynamics in the Bose-Hubbard model with local particle loss starting from a Mott-insulating initial state with one boson per site. While the short-time dynamics can be described even quantitatively by an equation of motion (EOM) approach at the mean-field level, many-body interactions lead to unexpected effects at intermediate and long times: local particle currents far away from the dissipative site start to reverse direction ultimately leading to a metastable state with a total particle current pointing away from the lossy site. An alternative EOM approach based on an effective fermion model shows that the reversal of currents can be understood qualitatively by the creation of holon-doublon pairs at the edge of the region of reduced particle density. The doublons are then able to escape while the holes move towards the dissipative site, a process reminiscent—in a loose sense—of Hawking radiation.

  16. Fed-state gastric media and drug analysis techniques: Current status and points to consider.

    Science.gov (United States)

    Baxevanis, Fotios; Kuiper, Jesse; Fotaki, Nikoletta

    2016-10-01

    Gastric fed state conditions can have a significant effect on drug dissolution and absorption. In vitro dissolution tests with simple aqueous media cannot usually predict drugs' in vivo response, as several factors such as the meal content, the gastric emptying and possible interactions between food and drug formulations can affect drug's pharmacokinetics. Good understanding of the effect of the in vivo fed gastric conditions on the drug is essential for the development of biorelevant dissolution media simulating the gastric environment after the administration of the standard high fat meal proposed by the FDA and the EMA in bioavailability/bioequivalence (BA/BE) studies. The analysis of drugs in fed state media can be quite challenging as most analytical protocols currently employed are time consuming and labour intensive. In this review, an overview of the in vivo gastric conditions and the biorelevant media used for their in vitro simulation are described. Furthermore an analysis of the physicochemical properties of the drugs and the formulations related to food effect is given. In terms of drug analysis, the protocols currently used for the fed state media sample treatment and analysis and the analytical challenges and needs emerging for more efficient and time saving techniques for a broad spectrum of compounds are being discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Finite-dimensional global attractors for parabolic nonlinear equations with state-dependent delay

    Czech Academy of Sciences Publication Activity Database

    Chueshov, I.; Rezunenko, Oleksandr

    2015-01-01

    Roč. 14, č. 5 (2015), s. 1685-1704 ISSN 1534-0392 R&D Projects: GA ČR GAP103/12/2431 Institutional support: RVO:67985556 Keywords : Parabolic evolution equations * state-dependent delay * global attractor * finite-dimension * exponential attractor Subject RIV: BC - Control Systems Theory Impact factor: 0.926, year: 2015 http://library.utia.cas.cz/separaty/2015/AS/rezunenko-0444705.pdf

  18. Dynamics of second order in time evolution equations with state-dependent delay

    Czech Academy of Sciences Publication Activity Database

    Chueshov, I.; Rezunenko, Oleksandr

    123-124, č. 1 (2015), s. 126-149 ISSN 0362-546X R&D Projects: GA ČR GAP103/12/2431 Institutional support: RVO:67985556 Keywords : Second order evolution equations * State dependent delay * Nonlinear plate * Finite-dimensional attractor Subject RIV: BD - Theory of Information Impact factor: 1.125, year: 2015 http://library.utia.cas.cz/separaty/2015/AS/rezunenko-0444708.pdf

  19. On time transformations for differential equations with state-dependent delay

    Czech Academy of Sciences Publication Activity Database

    Rezunenko, Oleksandr

    2014-01-01

    Roč. 12, č. 2 (2014), s. 298-307 ISSN 1895-1074 R&D Projects: GA ČR GAP103/12/2431 Institutional support: RVO:67985556 Keywords : differential equations * state-dependent delay * time transformations Subject RIV: BD - Theory of Information Impact factor: 0.578, year: 2014 http://library.utia.cas.cz/separaty/2014/AS/rezunenko-0429130.pdf

  20. Parabolic partial differential equations with discrete state-dependent delay: Classical solutions and solution manifold

    Czech Academy of Sciences Publication Activity Database

    Krisztin, T.; Rezunenko, Oleksandr

    2016-01-01

    Roč. 260, č. 5 (2016), s. 4454-4472 ISSN 0022-0396 R&D Projects: GA ČR GAP103/12/2431 Institutional support: RVO:67985556 Keywords : Parabolic partial differential equations * State dependent delay * Solution manifold Subject RIV: BC - Control Systems Theory Impact factor: 1.988, year: 2016 http://library.utia.cas.cz/separaty/2016/AS/rezunenko-0457879.pdf

  1. Algorithms to Solve Stochastic H2/H∞ Control with State-Dependent Noise

    Directory of Open Access Journals (Sweden)

    Ming Gao

    2014-01-01

    Full Text Available This paper is concerned with the algorithms which solve H2/H∞ control problems of stochastic systems with state-dependent noise. Firstly, the algorithms for the finite and infinite horizon H2/H∞ control of discrete-time stochastic systems are reviewed and studied. Secondly, two algorithms are proposed for the finite and infinite horizon H2/H∞ control of continuous-time stochastic systems, respectively. Finally, several numerical examples are presented to show the effectiveness of the algorithms.

  2. In vivo optogenetic stimulation of neocortical excitatory neurons drives brain-state-dependent inhibition.

    Science.gov (United States)

    Mateo, Celine; Avermann, Michael; Gentet, Luc J; Zhang, Feng; Deisseroth, Karl; Petersen, Carl C H

    2011-10-11

    Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice preparations in vitro. Here, we investigate brain-state-dependent neocortical synaptic interactions in vivo by combining the specificity of optogenetic stimulation with the precision of whole-cell recordings from postsynaptic excitatory glutamatergic neurons and GFP-labeled inhibitory GABAergic neurons targeted through two-photon microscopy. Channelrhodopsin-2 (ChR2) stimulation of excitatory layer 2/3 barrel cortex neurons evoked larger and faster depolarizing postsynaptic potentials and more synaptically driven action potentials in fast-spiking (FS) GABAergic neurons compared to both non-fast-spiking (NFS) GABAergic neurons and postsynaptic excitatory pyramidal neurons located within the same neocortical microcircuit. The number of action potentials evoked in ChR2-expressing neurons showed low trial-to-trial variability, but postsynaptic responses varied strongly with near-linear dependence upon spontaneously driven changes in prestimulus membrane potential. Postsynaptic responses in excitatory neurons had reversal potentials, which were hyperpolarized relative to action potential threshold and were therefore inhibitory. Reversal potentials measured in postsynaptic GABAergic neurons were close to action potential threshold. Postsynaptic inhibitory neurons preferentially fired synaptically driven action potentials from spontaneously depolarized network states, with stronger state-dependent modulation in NFS GABAergic neurons compared to FS GABAergic neurons. Inhibitory neurons appear to dominate neocortical microcircuit function, receiving stronger local excitatory synaptic input and firing more action potentials compared to excitatory neurons. In mouse layer 2/3 barrel cortex, we propose that strong state-dependent

  3. Charge carrier transport in Cu(In,Ga)Se2 thin-film solar-cells studied by electron beam induced current and temperature and illumination dependent current voltage analysis

    International Nuclear Information System (INIS)

    Nichterwitz, Melanie

    2012-01-01

    This work contributes to the understanding of generation dependent charge-carrier transport properties in Cu(In,Ga)Se 2 (CIGSe)/ CdS/ ZnO solar cells and a consistent model for the electronic band diagram of the heterojunction region of the device is developed. Cross section electron-beam induced current (EBIC) and temperature and illumination dependent current voltage (IV) measurements are performed on CIGSe solar cells with varying absorber layer compositions and CdS thickness. For a better understanding of possibilities and limitations of EBIC measurements applied on CIGSe solar cells, detailed numerical simulations of cross section EBIC profiles for varying electron beam and solar cell parameters are performed and compared to profiles obtained from an analytical description. Especially the effects of high injection conditions are considered. Even though the collection function of the solar cell is not independent of the generation function of the electron beam, the local electron diffusion length in CIGSe can still be extracted. Grain specific values ranging from (480±70) nm to (2.3±0.2) μm are determined for a CuInSe 2 absorber layer and a value of (2.8±0.3) μm for CIGSe with a Ga-content of 0.3. There are several models discussed in literature to explain generation dependent charge carrier transport, all assuming a high acceptor density either located in the CIGSe layer close to the CIGSe/CdS interface (p + layer), within the CdS layer or at the CdS/ZnO interface. In all models, a change in charge carrier collection properties is caused by a generation dependent occupation probability of the acceptor type defect state and the resulting potential distribution throughout the device. Numerical simulations of EBIC and IV data are performed with parameters according to these models. The model that explains the experimental data best is that of a p + layer at the CIGSe/CdS interface and acceptor type defect states at the CdS/ZnO interface. The p + layer leads

  4. Spectra and quantum efficiency of light-emitting diodes based on GaN heterostructures with quantum wells and their dependence on current and voltage

    CERN Document Server

    Kudryashov, V E; Turkin, A N; Yunovich, A E; Kovalev, A N; Manyakhin, F I

    2001-01-01

    Spectra and quantum efficiency of light-emitted diodes based on heterostructures InGaN/AlGaN/GaN with multiple quantum wells have been studied at currents J = 10 sup - sup 6 -10 sup - sup 1 A. Minor differences in quantum efficiency (of +- 10% at J approx = 10 mA) are caused by sufficiently different distribution of effective charges in the space charge region as well as by different role of the tunnel component of current at low voltages. The main peak in spectra near of 2.35-2.36 eV at small current (0.05-0.5 mA) does not depend on the voltage and is explained by radiative transitions in localized states. At J > 1 mA the spectral band 2.36-2.52 eV shifts with gamma current. The band form is described in the 4-parameter model of tail population of two-dimensional energy-level density

  5. Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

    Directory of Open Access Journals (Sweden)

    Christopher J Hyatt

    Full Text Available Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI in current (CCD; n = 30 and former (FCD; n = 28 cocaine dependent subjects as well as healthy control (HC; n = 31 subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses.

  6. Current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients

    Directory of Open Access Journals (Sweden)

    Suhail Ahmed Almani

    2017-01-01

    Full Text Available Objective: The present study aimed to evaluate the current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients. Study Design: This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016. Subjects and Methods: Of 921 blood samples, A. baumannii strains were isolated from 100 blood samples. Blood samples were processed for the isolation, identification, and drugs sensitivity as per the Clinical and Laboratory Standards Institute. A. baumannii strains were identified by microbiological methods and Gram's staining. API 20 E kit (Biomeriuex, USA was also used for identification. Data were analyzed on Statisti × 8.1 (USA. Results: Mean ± standard deviation age was 11.5 ± 2.8 years. Nearly 70% were male and 30% were female (P = 0.0001. Of 921 blood transfusion-dependent thalassemia patients, 100 (10.8% patients showed growth of A. baumannii. Drug resistance was observed against the ceftazidime, cefixime, cefepime, imipenem, meropenem, amikacin, minocycline, tigecycline, and tazocin except for the colistin. Conclusion: The present study reports drug-resistant A. baumannii in blood transfusion-dependent thalassemia patients. National multicenter studies are recommended to estimate the size of the problem.

  7. Current Trends of Drug Resistance Patterns of Acinetobacter baumannii Infection in Blood Transfusion-dependent Thalassemia Patients.

    Science.gov (United States)

    Almani, Suhail Ahmed; Naseer, Ali; Maheshwari, Sanjay Kumar; Maroof, Pir; Naseer, Raza; Khoharo, Haji Khan

    2017-01-01

    The present study aimed to evaluate the current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients. This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016. Of 921 blood samples, A. baumannii strains were isolated from 100 blood samples. Blood samples were processed for the isolation, identification, and drugs sensitivity as per the Clinical and Laboratory Standards Institute. A. baumannii strains were identified by microbiological methods and Gram's staining. API 20 E kit (Biomeriuex, USA) was also used for identification. Data were analyzed on Statisti × 8.1 (USA). Mean ± standard deviation age was 11.5 ± 2.8 years. Nearly 70% were male and 30% were female ( P = 0.0001). Of 921 blood transfusion-dependent thalassemia patients, 100 (10.8%) patients showed growth of A. baumannii . Drug resistance was observed against the ceftazidime, cefixime, cefepime, imipenem, meropenem, amikacin, minocycline, tigecycline, and tazocin except for the colistin. The present study reports drug-resistant A. baumannii in blood transfusion-dependent thalassemia patients. National multicenter studies are recommended to estimate the size of the problem.

  8. Functional coupling between sodium-activated potassium channels and voltage-dependent persistent sodium currents in cricket Kenyon cells.

    Science.gov (United States)

    Takahashi, Izumi; Yoshino, Masami

    2015-10-01

    In this study, we examined the functional coupling between Na(+)-activated potassium (KNa) channels and Na(+) influx through voltage-dependent Na(+) channels in Kenyon cells isolated from the mushroom body of the cricket Gryllus bimaculatus. Single-channel activity of KNa channels was recorded with the cell-attached patch configuration. The open probability (Po) of KNa channels increased with increasing Na(+) concentration in a bath solution, whereas it decreased by the substitution of Na(+) with an equimolar concentration of Li(+). The Po of KNa channels was also found to be reduced by bath application of a high concentration of TTX (1 μM) and riluzole (100 μM), which inhibits both fast (INaf) and persistent (INaP) Na(+) currents, whereas it was unaffected by a low concentration of TTX (10 nM), which selectively blocks INaf. Bath application of Cd(2+) at a low concentration (50 μM), as an inhibitor of INaP, also decreased the Po of KNa channels. Conversely, bath application of the inorganic Ca(2+)-channel blockers Co(2+) and Ni(2+) at high concentrations (500 μM) had little effect on the Po of KNa channels, although Cd(2+) (500 μM) reduced the Po of KNa channels. Perforated whole cell clamp analysis further indicated the presence of sustained outward currents for which amplitude was dependent on the amount of Na(+) influx. Taken together, these results indicate that KNa channels could be activated by Na(+) influx passing through voltage-dependent persistent Na(+) channels. The functional significance of this coupling mechanism was discussed in relation to the membrane excitability of Kenyon cells and its possible role in the formation of long-term memory. Copyright © 2015 the American Physiological Society.

  9. Assessment of Energy Production Potential from Ocean Currents along the United States Coastline

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Kevin

    2013-09-15

    Increasing energy consumption and depleting reserves of fossil fuels have resulted in growing interest in alternative renewable energy from the ocean. Ocean currents are an alternative source of clean energy due to their inherent reliability, persistence and sustainability. General ocean circulations exist in the form of large rotating ocean gyres, and feature extremely rapid current flow in the western boundaries due to the Coriolis Effect. The Gulf Stream system is formed by the western boundary current of the North Atlantic Ocean that flows along the east coastline of the United States, and therefore is of particular interest as a potential energy resource for the United States. This project created a national database of ocean current energy resources to help advance awareness and market penetration in ocean current energy resource assessment. The database, consisting of joint velocity magnitude and direction probability histograms, was created from data created by seven years of numerical model simulations. The accuracy of the database was evaluated by ORNL?s independent validation effort documented in a separate report. Estimates of the total theoretical power resource contained in the ocean currents were calculated utilizing two separate approaches. Firstly, the theoretical energy balance in the Gulf Stream system was examined using the two-dimensional ocean circulation equations based on the assumptions of the Stommel model for subtropical gyres with the quasi-geostrophic balance between pressure gradient, Coriolis force, wind stress and friction driving the circulation. Parameters including water depth, natural dissipation rate and wind stress are calibrated in the model so that the model can reproduce reasonable flow properties including volume flux and energy flux. To represent flow dissipation due to turbines additional turbine drag coefficient is formulated and included in the model. Secondly, to determine the reasonableness of the total power

  10. Dependence of receptor potential and redox state of mitochondrial cytochromes on oxygen fraction measured in the blowfly eye in vivo

    NARCIS (Netherlands)

    Smits, R.P.; Jansonius, N.M.; Stavenga, D.G.

    1. The dependence of dark-adapted fly (Calliphora vicina) photoreceptors on oxygen was investigated by measuring the electroretinogram (ERG), the receptor potential, and the redox states of the mitochondrial cytochromes. The redox states were determined via reflection microspectrophotometry on

  11. Mid to late Holocene Leeuwin Current variability offshore southern Australia linked to ENSO state changes

    Science.gov (United States)

    Perner, Kerstin; Moros, Matthias; De Deckker, Patrick; Blanz, Thomas; Siegel, Herbert; Wacker, Lukas; Schneider, Ralph; Jansen, Eystein

    2015-04-01

    The El Niño-Southern Oscillation (ENSO), a key aspect of the Earth's climate, drives regional to global oceanic and climate changes on various time-scales. Differences in the temporal coverage of Holocene records for the more general state in El Niño frequency, however, restrict a comprehensive overview. Oceanic variability offshore southern Australia is linked to the Leeuwin Current (LC), an eastern boundary current, transporting tropical waters from the Indo Pacific Warm Pool region towards higher latitudes. Instrumental data, spanning the last few decades, document that ENSO modulates LC variability. Here we present new, well-dated time series from two marine sediment cores (MD03-2611 and SS0206-GC 15)of past LC variability, based on alkenone-derived sea-surface temperatures (SST) and planktonic foraminifera offshore southern Australia, an area affected by recent El Niño and La Niña events. Our reconstructions of ENSO-state changes cover the last 7,400 years. With transition into the mid Holocene [dates], we find clear evidence that oceanic conditions prevailed under the dominant influence of a persistent La Niña mode. A strong LC produces a stratified water column and establishes a permanent thermocline as seen in the high abundance of the 'tropical fauna' (Globoturborotalita rubescens, Globoturborotalita tenella and Globigerinella sacculifer (including G. trilobus)) and maximum SST offshore southern Australia. During this La Niña-state dominated period, we record at c. 5000 years BP the first short period of a strong El Niño-like-state, by a pronounced drop in abundance of the subtropical species Globigerinoides ruber and a reduced SST gradient between the two core sites. The Late Holocene (from 3,500 years BP onwards) period is characterized by centennial to millennial scale variability in the LC strength, which is accompanied by an overall decrease of SSTs offshore southern Australia. We link this LC variability to Late Holocene centennial

  12. The Current State of Surgical Ergonomics Education in U.S. Surgical Training: A Survey Study.

    Science.gov (United States)

    Epstein, Sherise; Tran, Bao N; Capone, Avery C; Ruan, Qing Z; Fukudome, Eugene Y; Ricci, Joseph A; Testa, Marcia A; Dennerlein, Jack T; Lee, Bernard T; Singhal, Dhruv

    2018-01-29

    The aim of this study was to characterize the current state of surgical ergonomics education in the United States. The burden of work-related musculoskeletal disorders (MSDs) in surgeons is high and no overarching strategy for redress exists. Twelve distinct specialties describe an unmet need for surgical ergonomics education (SEE). This study aimed to define the current state of SEE in U.S. surgical training programs. We performed a descriptive analysis of a 20-item questionnaire of ACGME-certified program directors from 14 surgical and interventional medical specialties. Formal SEE was defined as any organized education module that reviewed the occupation-specific burden of common work-related MSDs and described a framework for prevention via occupation-specific applied ergonomics. Program directors were queried regarding SEE provision, characteristics, and perceived trainee attitude toward the education. Questionnaires were received from 130 of 441 (29.5%) program directors. Two (1.5%) provided formal SEE and 33 (25.4%) provided informal SEE, which consisted of unstructured intraoperative directives and isolated lectures. Two programs previously provided SEE but discontinued the effort due to lack of an evidence-based framework and instructors. Trainees appeared to think that learning surgical ergonomics skills was a worthwhile time investment in 100% and 76.7% of current formal and informal SEE, respectively. SEE is rarely provided in any capacity (25.4%), let alone in a consistent or evaluable fashion (1.5%). Impediments to sustainable SEE include lack of an evidence-based framework for education and instructors. An evidence-based, reproducible, and accreditation council-compliant SEE module would be a valuable resource for the surgical and interventional medical communities.

  13. Shallow Lunar Seismic Activity and the Current Stress State of the Moon

    Science.gov (United States)

    Watters, Thomas R.; Weber, Renee C.; Collins, Geoffrey C.; Johnson, Catherine L.

    2017-01-01

    A vast, global network of more than 3200 lobate thrust fault scarps has been revealed in high resolution Lunar Reconnaissance Orbiter Camera (LROC) images. The fault scarps are very young, less than 50 Ma, based on their small scale and crisp appearance, crosscutting relations with small-diameter impact craters, and rates of infilling of associated small, shallow graben and may be actively forming today. The population of young thrust fault scarps provides a window into the recent stress state of the Moon and offers insight into the origin of global lunar stresses. The distribution of orientations of the fault scarps is non-random, inconsistent with isotropic stresses from late-stage global contraction as the sole source of stress. Modeling shows that tidal stresses contribute significantly to the current stress state of the lunar crust. Tidal stresses (orbital recession and diurnal tides) superimposed on stresses from global contraction result in non-isotropic compressional stress and may produce thrust faults consistent with lobate scarp orientations. At any particular point on the lunar surface, peak compressive stress will be reached at a certain time in the diurnal cycle. Coseismic slip events on currently active thrust faults are expected to be triggered when peak stresses are reached. Analysis of the timing of the 28 the shallow moonquakes recorded by the Apollo seismic network shows that 19 indeed occur when the Moon is closer to apogee, while only 9 shallow events occur when the Moon is closer to perigee. Here we report efforts to refine the model for the current stress state of the Moon by investigating the contribution of polar wander. Progress on relocating the epicentral locations of the shallow moonquakes using an algorithm designed for sparse networks is also reported.

  14. The History of Liquid Ear Acupuncture and the Current Scientific State of the Art

    Directory of Open Access Journals (Sweden)

    Daniela Litscher

    2016-06-01

    Full Text Available This short review article presents a current overview of existing publications and scientific results regarding liquid (ear acupuncture. The injection of liquids into defined acupuncture points of the ear is not a method commonly used in the Western world. The term liquid acupuncture has different definitions, which makes understanding each definition and differentiating one from the other difficult. General terms like pharmacopuncture, homeosiniatry, and liquid acupuncture, which all describe the method of injecting different kinds of drugs into a defined body acupuncture point, are used. This article presents the history of liquid acupuncture, as well as the current scientific state of the art, from the point of view of two European researchers. Some articles are discussed and a few practical examples are presented.

  15. Study of a Novel CT Used to Measure the Switch State Current of RSD

    Directory of Open Access Journals (Sweden)

    Li Web

    2006-06-01

    Full Text Available The measurement of the pulse switch state current of RSD (Reversely Switching Dynistor device is crucial to transmit the energy efficiently with high stability and reliability. The novel CT (current transformer centered on self-integrating Rogowski coil is proposed. The operation principle, methods for properly choosing electric parameters both of RSD-based pulse switch experimental loop and the self-integrating Rogowski coil are presented. The error characteristics of the CT instrumentation are analyzed. The prototype CT centered on the self-integrating Rogowski coil according to the proposed theory and methods are introduced. Experimental results acquired by the proposed CT system are given. Experimental results can verify the validity of the novel CT measurement system.

  16. Meson exchange current effects in the electroexcitation of magnetic states in closed shell nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Lallena, A.M.; Dehesa, J.S. (Granada Univ. (Spain). Dept. de Fisica Nuclear); Krewald, S. (Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.). Inst. fuer Kernphysik)

    1984-10-18

    A microscopic approach to evaluate the contributions of one-pion exchange currents to the inelastic (e, e') scattering form factor of closed shell nuclei is developed. Both segull and pionic parts of the two-body term are treated on the same footing and their final expressions are simple, clear and physically transparent. Application to the magnetic stretched states 4/sup -/(18.98 MeV) of /sup 16/O and 14/sup -/(6.74 MeV) of /sup 208/Pb is done. Agreement with the available experimental data is discussed. It is found that the effect of the meson exchange currents is a smooth but non-negligible enhancement (> or approx. 15% at the first scattering maximum) at small momentum transfers and an increase by a factor bigger than 1.5 in the region of the second maximum.

  17. Rapid Detection Strategies for the Global Threat of Zika Virus: Current State, New Hypotheses and Limitations

    Directory of Open Access Journals (Sweden)

    Shruti Shukla

    2016-10-01

    Full Text Available The current scenario regarding the widespread Zika virus (ZIKV has resulted in numerous diagnostic studies, specifically in South America and in locations where there is frequent entry of travelers returning from ZIKV-affected areas, including pregnant women with or without clinical symptoms of ZIKV infection. The World Health Organization, WHO, announced that millions of cases of ZIKV are likely to occur in the United States of America in the near future. This situation has created an alarming public health emergency of international concern requiring the detection of this life-threatening viral candidate due to increased cases of newborn microcephaly associated with ZIKV infection. Hence, this review reports possible methods and strategies for the fast and reliable detection of ZIKV with particular emphasis on current updates, knowledge and new hypotheses that might be helpful for medical professionals in poor and developing countries that urgently need to address this problem. In particular, we emphasize liposome-based biosensors. Although these biosensors are currently among the less popular tools for human disease detection, they have become useful tools for the screening and detection of pathogenic bacteria, fungi and viruses because of their versatile advantageous features compared to other sensing devices. This review summarizes the currently available methods employed for the rapid detection of ZIKV and suggests an innovative approach involving the application of a liposome-based hypothesis for the development of new strategies for ZIKV detection and their use as effective biomedicinal tools.

  18. State-dependent µ-opioid Modulation of Social Motivation – a model

    Directory of Open Access Journals (Sweden)

    Guro Engvig Loseth

    2014-12-01

    Full Text Available Social mammals engage in affiliative interactions both when seeking relief from negative affect and when searching for pleasure and joy. These two motivational states are both modulated by µ-opioid transmission. The µ-opioid receptor (MOR system in the brain mediates pain relief and reward behaviours, and is implicated in social reward processing and affiliative bonding across mammalian species. However, pharmacological manipulation of the µ-opioid system has yielded opposite effects on rodents and primates: in rodents, social motivation is generally increased by MOR agonists and reduced by antagonists, whereas the opposite pattern has been shown in primates. Here, we address this paradox by taking into account differences in motivational state. We first review evidence for µ-opioid mediation of reward processing, emotion regulation, and affiliation in humans, non-human primates, rodents and other species. Based on the consistent cross-species similarities in opioid functioning, we propose a unified, state-dependent model for µ-opioid modulation of affiliation across the mammalian species. Finally, we show that this state-dependent model is supported by evidence from both rodent and primate studies, when species and age differences in social separation response are taken into account.

  19. Life cycle impacts and costs of photovoltaic systems: Current state of the art and future outlooks

    International Nuclear Information System (INIS)

    Raugei, Marco; Frankl, Paolo

    2009-01-01

    The photovoltaic energy sector is rapidly expanding and technological specification for PV has improved dramatically in the last two decades. This paper sketches the current state of the art and drafts three alternative scenarios for the future, in terms of costs, market penetration and environmental performance. According to these scenarios, if economic incentives are supported long enough into the next ten to twenty years, PV looks set for a rosy future, and is likely to play a significant role in the future energy mix, while at the same time contributing to reduce the environmental impact of electricity supply. (author)

  20. Fractal-Based Methods and Inverse Problems for Differential Equations: Current State of the Art

    Directory of Open Access Journals (Sweden)

    Herb E. Kunze

    2014-01-01

    Full Text Available We illustrate, in this short survey, the current state of the art of fractal-based techniques and their application to the solution of inverse problems for ordinary and partial differential equations. We review several methods based on the Collage Theorem and its extensions. We also discuss two innovative applications: the first one is related to a vibrating string model while the second one considers a collage-based approach for solving inverse problems for partial differential equations on a perforated domain.

  1. Passive measurement of flux nucleation in the current-induced resistive state of type I superconductors

    International Nuclear Information System (INIS)

    Selig, K.P.; Chimenti, D.E.; Huebener, R.P.

    1978-01-01

    Flux-tube nucleation rates have been measured in the current-induced resistive state of type I superconducting In films between 1.5 and 2.0 K by a completely passive technique. Indication of periodic nucleation is observed only in narrow regions of sample voltage drop, whose position is a sensitive function of temperature. Frequency bandwidth measurements of the nucleation rate yield a spectral purity of one part in 10 4 within the narrow regions where an experimental signal can be detected. (orig.) [de

  2. Current state of the art in science and technology, as seen by atomic energy law

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    The decision of the Fed. Adm. Court (BVerwG) deals with the obligation of the licensing authority, to apply the current state of the art in science and technology in its appraisal of appropriate measures for prevention of damage possibly arising out of the operation of a nuclear reactor, and for assessment and evaluation of the risks involved. It also deals with aspects of legal protection of third parties by provisions relating to the licensing procedure under atomic energy law, and with the question whether Art. 6 of the European Human Rights Convention can be applied to institute additional proceedings in the second instance with a public hearing. (RST) [de

  3. Current State of Agile Methodologies Worldwide and in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Martin Tománek

    2015-06-01

    Full Text Available The objective of this research paper is to compare the current state of agile methodologies in the world and in the Czech Republic. The comparison is executed as the comparative analysis of two publicly available researches conducted in 2013 and published in 2014. The comparison is further enriched by the results of the unpublished survey in the global logistics company which was conducted also in 2013. The potential trend for agile methodologies in the Czech Republic is also discussed with regard to the worldwide trend.

  4. The current state of the art of quantitative phosphoproteomics and its applications to diabetes research

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Chi Yuet X’avia; Gritsenko, Marina A.; Smith, Richard D.; Qian, Wei-Jun

    2016-03-17

    Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been revealed in various human diseases. Kinases and their cognate inhibitors have been hotspot for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for the disease of interest. In this review, we will highlight recent advances in phosphoproteomics, the current state-of-the-art of the technologies, and the challenges and future perspectives of this research area. Finally, we will underscore some exemplary applications of phosphoproteomics in diabetes research.

  5. Globalization of Gerontology Education: Current Practices and Perceptions for Graduate Gerontology Education in the United States

    Science.gov (United States)

    MWANGI, SAMUEL M.; YAMASHITA, TAKASHI; EWEN, HEIDI H.; MANNING, LYDIA K.; KUNKEL, SUZANNE R.

    2013-01-01

    The purpose of this study is to document current practices and understandings about globalization of gerontology education in the United States. Better understanding of aging requires international perspectives in global communities. However, little is known about how globalization of gerontology education is practiced in U.S. graduate-level degree programs. The authors conducted qualitative interviews with representatives of the Association for Gerontology in Higher Education, the major national organization supporting higher education in gerontology, graduate program directors, and students. Although all respondents expressed their interest in globalizing gerontology education, actual practices are diverse. The authors discuss suggested conceptualization and strategies for globalizing gerontology education. PMID:22490075

  6. Current and future developments in managed care in the United States and implications for Europe

    Directory of Open Access Journals (Sweden)

    Aspling Deborah L

    2005-03-01

    Full Text Available Abstract The paper reviews and evaluates current and future approaches to cost containment in the United States. Managed care was once seen as an effective approach to supporting health care quality while containing costs in the USA. In recent years payors started to look in other directions, since prospects for limiting expenses faded. Nowadays consumer driven health plans seem to be on the rise. The reasons for the decline of managed care, the growing popularity of the consumer driven health plans and the implications for Europe are discussed.

  7. Globalization of gerontology education: current practices and perceptions for graduate gerontology education in the United States.

    Science.gov (United States)

    Mwangi, Samuel M; Yamashita, Takashi; Ewen, Heidi H; Manning, Lydia K; Kunkel, Suzanne R

    2012-01-01

    The purpose of this study is to document current practices and understandings about globalization of gerontology education in the United States. Better understanding of aging requires international perspectives in global communities. However, little is known about how globalization of gerontology education is practiced in U.S. graduate-level degree programs. The authors conducted qualitative interviews with representatives of the Association for Gerontology in Higher Education, the major national organization supporting higher education in gerontology, graduate program directors, and students. Although all respondents expressed their interest in globalizing gerontology education, actual practices are diverse. The authors discuss suggested conceptualization and strategies for globalizing gerontology education.

  8. International conference. Mental health consequences of the Chernobyl disaster: current state and future prospects

    International Nuclear Information System (INIS)

    Nyagu, A.I.

    1995-01-01

    Proceedings of the International Conference on the mental health consequences of the Chernobyl disaster: current state and future prospects was introduced.The questions connected with: 1. Mental health disorders biological basis after ionizing radiation influence; 2. Psychiatric aspects of the Chernobyl disaster; 3. Social stress following contradictory information: ways for its overcoming; 4. Rehabilitation and prophylactic measures for mental and nervous disorders. Psycho social rehabilitation of survivors; 5. Psychosomatic effects and somato-neurological consequences of the Chernobyl disaster; 6. Psychosomatic health of children and adolescents survivors of the Chernobyl disaster; 7. Brain damage as result of prenatal irradiation

  9. Microstates in resting-state EEG: current status and future directions.

    Science.gov (United States)

    Khanna, Arjun; Pascual-Leone, Alvaro; Michel, Christoph M; Farzan, Faranak

    2015-02-01

    Electroencephalography (EEG) is a powerful method of studying the electrophysiology of the brain with high temporal resolution. Several analytical approaches to extract information from the EEG signal have been proposed. One method, termed microstate analysis, considers the multichannel EEG recording as a series of quasi-stable "microstates" that are each characterized by a unique topography of electric potentials over the entire channel array. Because this technique simultaneously considers signals recorded from all areas of the cortex, it is capable of assessing the function of large-scale brain networks whose disruption is associated with several neuropsychiatric disorders. In this review, we first introduce the method of EEG microstate analysis. We then review studies that have discovered significant changes in the resting-state microstate series in a variety of neuropsychiatric disorders and behavioral states. We discuss the potential utility of this method in detecting neurophysiological impairments in disease and monitoring neurophysiological changes in response to an intervention. Finally, we discuss how the resting-state microstate series may reflect rapid switching among neural networks while the brain is at rest, which could represent activity of resting-state networks described by other neuroimaging modalities. We conclude by commenting on the current and future status of microstate analysis, and suggest that EEG microstates represent a promising neurophysiological tool for understanding and assessing brain network dynamics on a millisecond timescale in health and disease. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Examination of the Current Approaches to State-Level Nuclear Security Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chan; Yim, Mansung; Kim, So Young [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    An effective global nuclear materials security system will cover all materials, employ international standards and best practices, and reduce risks by reducing weapons-usable nuclear material stocks and the number of locations where they are found. Such a system must also encourage states to accept peer reviews by outside experts in order to demonstrate that effective security is in place. It is thus critically important to create an integrative framework of state-level evaluation of nuclear security as a basis for measuring the level and progress of international effort to secure and control all nuclear materials. There have been studies to represent state-level nuclear security with a quantitative metric. A prime example is the Nuclear Materials Security Index (NMSI) by the Nuclear Threat Initiative (NTI). Another comprehensive study is the State Level Risk Metric by Texas A and M University (TAMU). This paper examines the current methods with respect to their strengths and weaknesses and identifies the directions for future research to improve upon the existing approaches.

  11. Temperature-Dependent Light-Stabilized States in Thin-Film PV Modules: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Deceglie, Michael G.; Silverman, Timothy J.; Marion, Bill; Kurtz, Sarah R.

    2015-09-17

    Thin-film photovoltaic modules are known to exhibit light-induced transient behavior which interferes with accurate and repeatable measurements of power. Typically power measurements are made after a light exposure in order to target a 'light state' of the module that is representative of outdoor performance. Here we show that the concept of a unique light state is poorly defined for both CIGS and CdTe modules. Instead we find that their metastable state after a light exposure can depend on the temperature of the module during the exposure. We observe changes in power as large as 5.8% for a 20 degrees C difference in light exposure temperature. These results lead us to conclude that for applications in which reproducibility and repeatability are critical, module temperature should be tightly controlled during light exposure.

  12. Detection-dependent six-photon Holland-Burnett state interference

    Science.gov (United States)

    Jin, Rui-Bo; Fujiwara, Mikio; Shimizu, Ryosuke; Collins, Robert J.; Buller, Gerald S.; Yamashita, Taro; Miki, Shigehito; Terai, Hirotaka; Takeoka, Masahiro; Sasaki, Masahide

    2016-11-01

    The NOON state, and its experimental approximation the Holland-Burnett state, have important applications in phase sensing measurement with enhanced sensitivity. However, most of the previous Holland-Burnett state interference (HBSI) experiments only investigated the area of the interference pattern in the region immediately around zero optical path length difference, while the full HBSI pattern over a wide range of optical path length differences has not yet been well explored. In this work, we experimentally and theoretically demonstrate up to six-photon HBSI and study the properties of the interference patterns over a wide range of optical path length differences. It was found that the shape, the coherence time and the visibility of the interference patterns were strongly dependent on the detection schemes. This work paves the way for applications which are based on the envelope of the HBSI pattern, such as quantum spectroscopy and quantum metrology.

  13. State-dependent access to the batrachotoxin receptor on the sodium channel.

    Science.gov (United States)

    De Leon, Lyn; Ragsdale, David S

    2003-07-18

    Batrachotoxin causes sustained opening of voltage-gated sodium channels. Toxin binds irreversibly to wild type channels; however, it dissociates rapidly from channels with mutation F1710C in transmembrane segment IVS6. This dissociation requires channel activation, suggesting that the activation gate guards the toxin-binding site. Here we show that activity-dependent toxin dissociation was not affected by external sodium, arguing against a binding site within the pore, and demonstrate that dissociation occurred only during the first few milliseconds after membrane depolarization, as if the toxin leaves its binding site during closed states that precede the final open state in the activation pathway. Toxin interaction with preopen states may facilitate subsequent channel opening, thus accounting for the batrachotoxin-induced negative shift in channel activation.

  14. State income tax policy and family size: fertility and the dependency exemption.

    Science.gov (United States)

    Whittington, L A

    1993-10-01

    Data from the Panel Study on Income Dynamics, excluding the low income Survey of Economic Opportunity, were used to test an empirical model of the relationship between US state tax exemption values and tax rates for couples and fertility. Income is held constant so that the real tax exemption value is affected by changes in tax rates, the price level, or the statutory value of the exemption. Prior research by Whittington et al. found a positive relationship between births and the federal exemption between 1979-83 for 294 households. The tax value of the exemption varies widely across states. There are 41 states with substantial personal income taxes, while seven states have no state personal income taxes. A very limited tax on personal income is collected in Tennessee, New Hampshire, and Connecticut. Pennsylvania has no dependency exemption. The range in exemption varies from $1500 in Georgia to $300 in Alabama. Tax credits in lieu of exemptions vary from $6 in Arkansas to $85 in Oregon. Tax rates also vary across states. The value of the exemption lowers the cost of a child and is not constant over time. Six models are specified. Model 1 uses combined state and federal exemptions. Models 2 and 3 use a lagged combined exemption value of one and two years. Models 4 and 6 use state exemptions separated from federal exemptions. Model 5 uses a lag of one year, and model 6 uses a lag of two years. The estimation results of the conditional logit (Chamberlain) Model 1 show a negative and significant coefficient, which suggests that exemptions are not an incentive for births. In Models 2 and 3, the coefficient is positive and significant. In Model 4, the pattern of Model 1 holds except the sign is positive. In Models 5 and 6, the federal exemption is positive and significant, and the state exemption is negative and significant. When substitution is made with the means of the predicted values for the exemption, Models 1-4 all become positive and significant. In models with

  15. Power and uneven globalization: Coalitions and energy trade dependence in the newly independent states of Europe

    Science.gov (United States)

    Linden, Corina Herron

    2000-10-01

    The economies of the European former Soviet Union were dependent upon energy subsidies in the form of virtually free oil and natural gas imports from Russia, the loss of which implied dramatic shocks to domestic production structures, and the maintenance of which implied continued policy concessions to Russia. Yet some of these states actively pursued integration into the global economy while others sought to maintain the shelter of domestic markets and Russian energy subsidies. While the economic costs of openness and restructuring would be high in all cases in the short term, it is the political costs of openness and restructuring that determine the policy of the state. Where the high costs of restructuring are borne by a politically disenfranchised group, a consensus coalition can emerge in favor of rapid restructuring and energy reorientation. Where the benefits of the status quo accrue to a well-organized coalition closely allied with the state, a consensus coalition emerges in favor of maintenance of energy subsidies from and political relationship with Russia. Where the costs of restructuring are borne broadly or by a well-organized minority group, power oscillation and fragmentation will lead to inconsistent policy and slow progress toward energy reorientation and reform. Integrating a state-in-society approach to coalition formation within the field of international political economy, the author argues that states dominated by globalist-liberalizing-nationalist coalitions were able to implement energy trade reorientation by politically disenfranchising the ethnic minorities who populated the sector most vulnerable to energy contraction, heavy industry. These "globalizers," Estonia and Latvia, bore the high costs of restructuring industries and importing energy at world prices. Belarus, dominated by pro-Moscow-statist-leftist coalitions, sought to preserve energy subsidies through political and economic reintegration with Russia. States ruled by divided

  16. Excited-state annihilation reduces power dependence of single-molecule FRET experiments.

    Science.gov (United States)

    Nettels, Daniel; Haenni, Dominik; Maillot, Sacha; Gueye, Moussa; Barth, Anders; Hirschfeld, Verena; Hübner, Christian G; Léonard, Jérémie; Schuler, Benjamin

    2015-12-28

    Single-molecule Förster resonance energy transfer (FRET) experiments are an important method for probing biomolecular structure and dynamics. The results from such experiments appear to be surprisingly independent of the excitation power used, in contradiction to the simple photophysical mechanism usually invoked for FRET. Here we show that excited-state annihilation processes are an essential cause of this behavior. Singlet-singlet annihilation (SSA) is a mechanism of fluorescence quenching induced by Förster-type energy transfer between two fluorophores while they are both in their first excited singlet states (S1S1), which is usually neglected in the interpretation of FRET experiments. However, this approximation is only justified in the limit of low excitation rates. We demonstrate that SSA is evident in fluorescence correlation measurements for the commonly used FRET pair Alexa 488/Alexa 594, with a rate comparable to the rate of energy transfer between the donor excited state and the acceptor ground state (S1S0) that is exploited in FRET experiments. Transient absorption spectroscopy shows that SSA occurs exclusively via energy transfer from Alexa 488 to Alexa 594. Excitation-power dependent microsecond correlation experiments support the conclusion based on previously reported absorption spectra of triplet states that singlet-triplet annihilation (STA) analogously mediates energy transfer if the acceptor is in the triplet state. The results indicate that both SSA and STA have a pronounced effect on the overall FRET process and reduce the power dependence of the observed FRET efficiencies. The existence of annihilation processes thus seems to be essential for using FRET as a reliable spectroscopic ruler at the high excitation rates commonly employed in single-molecule spectroscopy.

  17. Excited state intramolecular charge transfer reaction in nonaqueous electrolyte solutions: temperature dependence.

    Science.gov (United States)

    Pradhan, Tuhin; Gazi, Harun Al Rasid; Biswas, Ranjit

    2009-08-07

    Temperature dependence of the excited state intramolecular charge transfer reaction of 4-(1-azetidinyl)benzonitrile (P4C) in ethyl acetate (EA), acetonitrile (ACN), and ethanol at several concentrations of lithium perchlorate (LiClO(4)) has been investigated by using the steady state and time resolved fluorescence spectroscopic techniques. The temperature range considered is 267-343 K. The temperature dependent spectral peak shifts and reaction driving force (-DeltaG(r)) in electrolyte solutions of these solvents can be explained qualitatively in terms of interaction between the reactant molecule and ion-atmosphere. Time resolved studies indicate that the decay kinetics of P4C is biexponential, regardless of solvents, LiClO(4) concentrations, and temperatures considered. Except at higher electrolyte concentrations in EA, reaction rates in solutions follow the Arrhenius-type temperature dependence where the estimated activation energy exhibits substantial electrolyte concentration dependence. The average of the experimentally measured activation energies in these three neat solvents is found to be in very good agreement with the predicted value based on data in room temperature solvents. While the rate constant in EA shows a electrolyte concentration induced parabolic dependence on reaction driving force (-DeltaG(r)), the former in ethanol and ACN increases only linearly with the increase in driving force (-DeltaG(r)). The data presented here also indicate that the step-wise increase in solvent reorganization energy via sequential addition of electrolyte induces the ICT reaction in weakly polar solvents to crossover from the Marcus inverted region to the normal region.

  18. Evaluating the current state of the art of Huntington disease research: a scientometric analysis.

    Science.gov (United States)

    Barboza, L A; Ghisi, N C

    2018-01-11

    Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed to examine the current state-of-the-art approaches that foster researchers' understandings of the current knowledge, research trends, and research gaps regarding this disorder. We performed literature searches of articles that were published up to September 2016 in the "ISI Web of Science™" (http://apps.webofknowledge.com/). The keyword used was "Huntington disease". Of the initial 14,036 articles that were obtained, 7732 were eligible for inclusion in the study according to their relevance. Data were classified according to language, country of publication, year, and area of concentration. The country leader regarding the number of studies published on HD is the United States, accounting for nearly 30% of all publications, followed by England and Germany, who have published 10 and 7% of all publications, respectively. Regarding the language in which the articles were written, 98% of publications were in English. The first publication to be found on HD was published in 1974. A surge of publications on HD can be seen from 1996 onward. In relation to the various knowledge areas that emerged, most publications were in the fields of neuroscience and neurology, likely because HD is a neurodegenerative disorder. Publications written in areas such as psychiatry, genetics, and molecular biology also predominated.

  19. Mass Casualty Decontamination in the United States: An Online Survey of Current Practice.

    Science.gov (United States)

    Power, Sarah; Symons, Charles; Carter, Holly; Jones, Emma; Amlôt, Richard; Larner, Joanne; Matar, Hazem; Chilcott, Robert P

    2016-01-01

    Mass casualty decontamination is a public health intervention that would be employed by emergency responders following a chemical, biological, or radiological incident. The decontamination of large numbers of casualties is currently most often performed with water to remove contaminants from the skin surface. An online survey was conducted to explore US fire departments' decontamination practices and their preparedness for responding to incidents involving mass casualty decontamination. Survey respondents were asked to provide details of various aspects of their decontamination procedures, including expected response times to reach casualties, disrobing procedures, approaches to decontamination, characteristics of the decontamination showering process, provision for special populations, and any actions taken following decontamination. The aim of the survey was to identify any differences in the way in which decontamination guidance is implemented across US states. Results revealed that, in line with current guidance, many US fire departments routinely use the "ladder-pipe system" for conducting rapid, gross decontamination of casualties. The survey revealed significant variability in ladder-pipe construction, such as the position and number of fire hoses used. There was also variability in decontamination characteristics, such as water temperature and water pressure, detergent use, and shower duration. The results presented here provide important insights into the ways in which implementation of decontamination guidance can vary between US states. These inconsistencies are thought to reflect established perceived best practices and local adaptation of response plans to address practical and logistical constraints. These outcomes highlight the need for evidence-based national guidelines for conducting mass casualty decontamination.

  20. Current State of Technology of Fuel Cell Power Systems for Autonomous Underwater Vehicles

    Directory of Open Access Journals (Sweden)

    Alejandro Mendez

    2014-07-01

    Full Text Available Autonomous Underwater Vehicles (AUVs are vehicles that are primarily used to accomplish oceanographic research data collection and auxiliary offshore tasks. At the present time, they are usually powered by lithium-ion secondary batteries, which have insufficient specific energies. In order for this technology to achieve a mature state, increased endurance is required. Fuel cell power systems have been identified as an effective means to achieve this endurance but no implementation in a commercial device has yet been realized. This paper summarizes the current state of development of the technology in this field of research. First, the most adequate type of fuel cell for this application is discussed. The prototypes and design concepts of AUVs powered by fuel cells which have been developed in the last few years are described. Possible commercial and experimental fuel cell stack options are analyzed, examining solutions adopted in the analogous aerial vehicle applications, as well as the underwater ones, to see if integration in an AUV is feasible. Current solutions in oxygen and hydrogen storage systems are overviewed and energy density is objectively compared between battery power systems and fuel cell power systems for AUVs. A couple of system configuration solutions are described including the necessary lithium-ion battery hybrid system. Finally, some closing remarks on the future of this technology are given.