36 CFR 1281.4 - What are the architectural and design standards for Presidential libraries?

Science.gov (United States)

2010-07-01

... and design standards for Presidential libraries? 1281.4 Section 1281.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES PRESIDENTIAL LIBRARY FACILITIES § 1281.4 What are the architectural and design standards for Presidential libraries? The Archivist is...

International Standardization of Library and Documentation Techniques.

Science.gov (United States)

International Federation for Documentation, The Hague (Netherlands).

This comparative study of the national and international standards, rules and regulations on library and documentation techniques adopted in various countries was conducted as a preliminary step in determining the minimal bases for facilitating national and international cooperation between documentalists and librarians. The study compares and…

Role of ''standard'' fine-group cross section libraries in shielding analysis

International Nuclear Information System (INIS)

Weisbin, C.R.; Roussin, R.W.; Oblow, E.M.; Cullen, D.E.; White, J.E.; Wright, R.Q.

1977-01-01

The Divisions of Magnetic Fusion Energy (DMFE) and Reactor Development and Demonstration (DRDD) of the United States Energy Research and Development Administration (ERDA) have jointly sponsored the development of a 171 neutron, 36 gamma ray group pseudo composition independent cross section library based upon ENDF/B-IV. This library (named VITAMIN-C and packaged by RSIC as DLC-41) is intended to be generally applicable to fusion blanket and LMFBR core and shield analysis. The purpose of this paper is to evaluate this library as a possible candidate for specific designation as a ''standard'' in light of American Nuclear Society standards for fine-group cross section data sets. The rationale and qualification procedure for such a standard are discussed. Finally, current limitations and anticipated extensions to this processed data file are described

Evaluation of Standard Concepts Design of Library Interior Physical Environment

Directory of Open Access Journals (Sweden)

Debri Harindya Putri

2018-01-01

Full Text Available Currently the function of a room is not only used as a shelter, the function of the room itself to be increased as a refreshing or relaxation area for users to follow the development of creativity and technology in the field of design. The comfortable factor becomes the main factor that indicates a successful process of creating a space. No exception library. The nature of library seemed stiff because of its function as a place to read, now can be developed and made into more dynamic with the special design concepts or color patterns used. Libraries can be created a special concept that suits the characteristics of the users themselves. Most users of the library, especially in college libraries are teenagers. Naturally, teenagers like to gather with their friends and we have to facilitate this activity in our library design concept. In addition we can also determine the needs of users through research by questionnaire method. The answers of users can be mapped and drawn conclusions. To explore the research, the author reviewed some literature about library interior design and observed the library of Ma Chung University as a case study. The combined results of the method can be concluded and the discovery of ideal standards of physical environment. So, the library can be made as a comfortable reading environment so as to increased interest in reading behavior and the frequent visits of students in the library

ENDF/B-V 7 Standards Data File (EN5-ST Library)

International Nuclear Information System (INIS)

DayDay, N.; Lemmel, H.D.

1980-10-01

This document summarizes the contents and documentation of the ENDF/B-V 7 Standards Data File (EN5-ST Library) released in September 1979. The library contains complete evaluations for all significant neutron reactions in the energy range 10 -5 eV to 20 MeV for H-1, He-3, Li-6, B-10, C-12, Au-197 and U-235 isotopes. The entire library or selective retrievals from it can be obtained free of charge from the IAEA Nuclear Data Section. (author)

End-user satisfaction analysis on library management system unnes using technology acceptance model towards national standard of integrated library

Science.gov (United States)

Hardyanto, W.; Purwinarko, A.; Adhi, M. A.

2018-03-01

The library which is the gate of the University should be supported by the existence of an adequate information system, to provide excellent service and optimal to every user. Library management system that has been in existence since 2009 needs to be re-evaluated so that the system can meet the needs of both operator and Unnes user in particular, and users from outside Unnes in general. This study aims to evaluate and improve the existing library management system to produce a system that is accountable and able to meet the needs of end users, as well as produce a library management system that is integrated Unnes. Research is directed to produce evaluation report with Technology Acceptance Model (TAM) approach and library management system integrated with the national standard.

A standard stellar library for evolutionary synthesis. III. Metallicity calibration

Science.gov (United States)

Westera, P.; Lejeune, T.; Buser, R.; Cuisinier, F.; Bruzual, G.

2002-01-01

We extend the colour calibration of the widely used BaSeL standard stellar library (Lejeune et al. 1997, 1998) to non-solar metallicities, down to [Fe/H] ~ -2.0 dex. Surprisingly, we find that at the present epoch it is virtually impossible to establish a unique calibration of UBVRIJHKL colours in terms of stellar metallicity [Fe/H] which is consistent simultaneously with both colour-temperature relations and colour-absolute magnitude diagrams (CMDs) based on observed globular cluster photometry data and on published, currently popular standard stellar evolutionary tracks and isochrones. The problem appears to be related to the long-standing incompleteness in our understanding of convection in late-type stellar evolution, but is also due to a serious lack of relevant observational calibration data that would help resolve, or at least further significant progress towards resolving this issue. In view of the most important applications of the BaSeL library, we here propose two different metallicity calibration versions: (1) the ``WLBC 99'' library, which consistently matches empirical colour-temperature relations and which, therefore, should make an ideal tool for the study of individual stars; and (2), the ``PADOVA 2000'' library, which provides isochrones from the Padova 2000 grid (Girardi et al. \\cite{padova}) that successfully reproduce Galactic globular-cluster colour-absolute magnitude diagrams and which thus should prove particularly useful for studies of collective phenomena in stellar populations in clusters and galaxies.

Status of standard cross section library and future plan

International Nuclear Information System (INIS)

Zukeran, Atsushi

2001-01-01

JSSTDL-300 multi-group cross section library with 300 neutron energy groups coupled with 104 group γ-ray cross sections was developed for general users in nuclear reactor physics and/or design, whose source data is the evaluated nuclear data library JENDL-3.2. For the purpose of a standard or common use, several famous cross section libraries worldwide used, i.e., ABBN-25, GAM-123, VITAMIN-C/J(E+C), MGCL-137, BERMUDA-12 and FNS-125 for neutron, and LANL-12, -24-, -48, and CSEWG-94 for γ-ray, are consulted about setting the common energy group structure. Furthermore, in order to expand the applicability, the top energy is set on 20 MeV and the lowest energy is 10 -5 eV. In the thermal neutron energy region, the JSSTDL-300 has about 20 energy groups. Besides, many utility codes for group collapsing and for data format transformation are provided for general users. (author)

Prison Library Services in Croatia Need Improvement to Meet International Standards of Universal Rights to Access

Directory of Open Access Journals (Sweden)

Carol Perryman

2016-09-01

. While use of the libraries was high, most responses reflected severely limited educational, rehabilitative or cultural programming and access to the internet, and lack of space for collections and reading purposes. Conclusion – Libraries in Croatia fail to meet international standards for staffing, collections, and services. Recommendations for immediate improvement are made, including legislative advocacy and funding, improved public library involvement, and the creation of national standards aligned with international standards.

Embracing Change: Adapting and Evolving Your Distance Learning Library Services to Meet the New ACRL Distance Learning Library Services Standards

Science.gov (United States)

Marcum, Brad

2016-01-01

This article examines the update and revision of the current Association of College and Research Libraries (ACRL) Distance Learning Standards that has been proposed and submitted to the ACRL Standards Committee. An in-depth analysis of the update is included, along with some comparisons between the old and new. Practical advice detailing…

Development of a standardized, citywide process for managing smart-pump drug libraries.

Science.gov (United States)

Walroth, Todd A; Smallwood, Shannon; Arthur, Karen; Vance, Betsy; Washington, Alana; Staublin, Therese; Haslar, Tammy; Reddan, Jennifer G; Fuller, James

2018-06-15

Development and implementation of an interprofessional consensus-driven process for review and optimization of smart-pump drug libraries and dosing limits are described. The Indianapolis Coalition for Patient Safety (ICPS), which represents 6 Indianapolis-area health systems, identified an opportunity to reduce clinically insignificant alerts that smart infusion pumps present to end users. Through a consensus-driven process, ICPS aimed to identify best practices to implement at individual hospitals in order to establish specific action items for smart-pump drug library optimization. A work group of pharmacists, nurses, and industrial engineers met to evaluate variability within and lack of scrutiny of smart-pump drug libraries. The work group used Lean Six Sigma methodologies to generate a list of key needs and barriers to be addressed in process standardization. The group reviewed targets for smart-pump drug library optimization, including dosing limits, types of alerts reviewed, policies, and safety best practices. The work group also analyzed existing processes at each site to develop a final consensus statement outlining a model process for reviewing alerts and managing smart-pump data. Analysis of the total number of alerts per device across ICPS-affiliated health systems over a 4-year period indicated a 50% decrease (from 7.2 to 3.6 alerts per device per month) after implementation of the model by ICPS member organizations. Through implementation of a standardized, consensus-driven process for smart-pump drug library optimization, ICPS member health systems reduced clinically insignificant smart-pump alerts. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Standardization of computer programs - basis of the Czechoslovak library of nuclear codes

International Nuclear Information System (INIS)

Gregor, M.

1987-01-01

A standardized form of computer code documentation has been established in the CSSR in the field of reactor safety. Structure and content of the documentation are described and codes already subject to this process are mentioned. The formation of a Czechoslovak nuclear code library and facilitated discussion of safety reports containing results of standardized codes are aimed at

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.

Science.gov (United States)

Theaker, Sarah M; Rius, Cristina; Greenshields-Watson, Alexander; Lloyd, Angharad; Trimby, Andrew; Fuller, Anna; Miles, John J; Cole, David K; Peakman, Mark; Sewell, Andrew K; Dolton, Garry

2016-03-01

Isolation of peptide-specific T-cell clones is highly desirable for determining the role of T-cells in human disease, as well as for the development of therapies and diagnostics. However, generation of monoclonal T-cells with the required specificity is challenging and time-consuming. Here we describe a library-based strategy for the simple parallel detection and isolation of multiple peptide-specific human T-cell clones from CD8(+) or CD4(+) polyclonal T-cell populations. T-cells were first amplified by CD3/CD28 microbeads in a 96U-well library format, prior to screening for desired peptide recognition. T-cells from peptide-reactive wells were then subjected to cytokine-mediated enrichment followed by single-cell cloning, with the entire process from sample to validated clone taking as little as 6 weeks. Overall, T-cell libraries represent an efficient and relatively rapid tool for the generation of peptide-specific T-cell clones, with applications shown here in infectious disease (Epstein-Barr virus, influenza A, and Ebola virus), autoimmunity (type 1 diabetes) and cancer. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Making operations on standard-library containers strongly exception safe

DEFF Research Database (Denmark)

Katajainen, Jyrki

2007-01-01

-library containers to provide the strong guarantee of exception safety, instead of the default guarantee, without violating the stringent performance requirements specified in the C++ standard. In particular, we show that every strongly exception-safe operation on dynamic arrays and ordered dictionaries is only...... a constant factor slower than the corresponding default-guarantee operation. In terms of the amount of space, the overhead introduced is linear in the number of elements stored....

Libraries and Accessibility: Istanbul Public Libraries Case

Directory of Open Access Journals (Sweden)

Gül Yücel

2016-12-01

Full Text Available In the study; the assessment of accessibility has been conducted in Istanbul public libraries within the scope of public area. Public libraries commonly serve with its user of more than 20 million in total, spread to the general of Turkey, having more than one thousand branches in the centrums and having more than one million registered members. The building principles and standards covering the subjects such as the selection of place, historical and architectural specification of the region, distance to the centre of population and design in a way that the disabled people could benefit from the library services fully have been determined with regulations in the construction of new libraries. There are works for the existent libraries such as access for the disabled, fire safety precautions etc. within the scope of the related standards. Easy access by everyone is prioritized in the public libraries having a significant role in life-long learning. The purpose of the study is to develop solution suggestions for the accessibility problems in the public libraries. The study based on the eye inspection and assessments carried out within the scope of accessibility in the public libraries subsidiary to Istanbul Culture and Tourism Provincial Directorate Library and Publications Department within the provincial borders of Istanbul. The arrangements such as reading halls, study areas, book shelves etc. have been examined within the frame of accessible building standards. Building entrances, ramps and staircases, horizontal and vertical circulation of building etc. have been taken into consideration within the scope of accessible building standards. The subjects such as the reading and studying areas and book shelf arrangements for the library have been assessed within the scope of specific buildings. There are a total of 34 public libraries subsidiary to Istanbul Culture and Tourism Provincial Directorate on condition that 20 ea. of them are in the

A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells

Directory of Open Access Journals (Sweden)

Seonmi Park

2017-04-01

Full Text Available Summary: Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated a diverse, comprehensive, and fully characterized library of sickle-cell-disease-specific induced pluripotent stem cells (iPSCs from patients of different ethnicities, β-globin gene (HBB haplotypes, and fetal hemoglobin (HbF levels. iPSCs stand to revolutionize the way we study human development, model disease, and perhaps eventually, treat patients. Here, we describe this unique resource for the study of sickle cell disease, including novel haplotype-specific polymorphisms that affect disease severity, as well as for the development of patient-specific therapeutics for this phenotypically diverse disorder. As a complement to this library, and as proof of principle for future cell- and gene-based therapies, we also designed and employed CRISPR/Cas gene editing tools to correct the sickle hemoglobin (HbS mutation. : In this resource article, Mostoslavsky, Murphy, and colleagues of the NextGen consortium describe a diverse, comprehensive, and characterized library of sickle cell disease-specific induced pluripotent stem cells (iPSCs from patients of different ethnicities, β-globin gene (HBB haplotypes and fetal hemoglobin (HbF levels. This bank is readily available and accessible to all investigators. Keywords: induced pluripotent stem cells, iPSCs, sickle cell disease, disease modeling, directed differentiation, gene correction

Featured Library: Parrish Library

OpenAIRE

Kirkwood, Hal P, Jr

2015-01-01

The Roland G. Parrish Library of Management & Economics is located within the Krannert School of Management at Purdue University. Between 2005 - 2007 work was completed on a white paper that focused on a student-centered vision for the Management & Economics Library. The next step was a massive collection reduction and a re-envisioning of both the services and space of the library. Thus began a 3 phase renovation from a 2 floor standard, collection-focused library into a single floor, 18,000s...

Novel β-lactamase-random peptide fusion libraries for phage display selection of cancer cell-targeting agents suitable for enzyme prodrug therapy

Science.gov (United States)

Shukla, Girja S.; Krag, David N.

2010-01-01

Novel phage-displayed random linear dodecapeptide (X12) and cysteine-constrained decapeptide (CX10C) libraries constructed in fusion to the amino-terminus of P99 β-lactamase molecules were used for identifying β-lactamase-linked cancer cell-specific ligands. The size and quality of both libraries were comparable to the standards of other reported phage display systems. Using the single-round panning method based on phage DNA recovery, we identified severalβ-lactamase fusion peptides that specifically bind to live human breast cancer MDA-MB-361 cells. The β-lactamase fusion to the peptides helped in conducting the enzyme activity-based clone normalization and cell-binding screening in a very time- and cost-efficient manner. The methods were suitable for 96-well readout as well as microscopic imaging. The success of the biopanning was indicated by the presence of ~40% cancer cell-specific clones among recovered phages. One of the binding clones appeared multiple times. The cancer cell-binding fusion peptides also shared several significant motifs. This opens a new way of preparing and selecting phage display libraries. The cancer cell-specific β-lactamase-linked affinity reagents selected from these libraries can be used for any application that requires a reporter for tracking the ligand molecules. Furthermore, these affinity reagents have also a potential for their direct use in the targeted enzyme prodrug therapy of cancer. PMID:19751096

Service Standards for the Mobile/Social Library

Science.gov (United States)

Thomas, Lisa Carlucci

2010-01-01

Customer service is at the core of everything librarians do in libraries. They strive to create positive customer relationships and to provide added value to the library services offered to their patrons. Emerging technologies offer opportunities for creative integration with library services. Staff should be encouraged to explore, learn, and…

Organization of a library of standard relocatible programmes, or a processing measurement data module based on computers of the TRA types

International Nuclear Information System (INIS)

Dadi, K.; Dadi, L.; Mateeva, A.; Salamatin, I.M.

1976-01-01

The paper describes the organization of a library of standard programs with binary cade. The library was developed for a measurement module on the basis of a TRA-1001-i computer (Elektronika-100, PDP-8). The library is placed on a external memory (magnetic disk) and has a module structure. The external memory assigned for the library is divided into pages. When loaded into the computer internal memory, several pages are taken as one whole to represent the loading module. The magnetic disk storage capacity being 1.25 million words, the library has a total of ca. 50 10 thousand words (eight cylinders). The work provides regulations for compiling standard programs in SLANG. The library is characterized by the following main features: possibility of being used in memory dynamic distribution mode; possibility of being used for computers with internal memory capacity 4K; no need for intermediary-language coding of displaced program; and possibility of autonomous shift of standard program. The above library is compared with a comprising DES programs library

Far Away, so Close: Preservices School Library Media Specialists' Perceptions of AASL's "Standards for the 21st-Century Learner"

Science.gov (United States)

Mardis, Marcia A.; Dickinson, Gail K.

2009-01-01

Preservice school library media specialists will implement the AASL Standards for the "21st Century Learner" in their new roles. Drafted in 2007, the Standards reflect principles which school library media specialist must impart to learners to prepare them to be knowledge consumers, producers, and communicators in global environments.…

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

Science.gov (United States)

Hiemstra, H S; van Veelen, P A; Schloot, N C; Geluk, A; van Meijgaarden, K E; Willemen, S J; Leunissen, J A; Benckhuijsen, W E; Amons, R; de Vries, R R; Roep, B O; Ottenhoff, T H; Drijfhout, J W

1998-10-15

Progress has recently been made in the use of synthetic peptide libraries for the identification of T cell-stimulating ligands. T cell epitopes identified from synthetic libraries are mimics of natural epitopes. Here we show how the mimicry epitopes obtained from synthetic peptide libraries enable unambiguous identification of natural T cell Ags. Synthetic peptide libraries were screened with Mycobacterium tuberculosis-reactive and -autoreactive T cell clones. In two cases, database homology searches with mimicry epitopes isolated from a dedicated synthetic peptide library allowed immediate identification of the natural antigenic protein. In two other cases, an amino acid pattern that reflected the epitope requirements of the T cell was determined by substitution and omission mixture analysis. Subsequently, the natural Ag was identified from databases using this refined pattern. This approach opens new perspectives for rapid and reliable Ag definition, representing a feasible alternative to the biochemical and genetic approaches described thus far.

Display of a Maize cDNA library on baculovirus infected insect cells

Directory of Open Access Journals (Sweden)

Jones Ian M

2008-08-01

Full Text Available Abstract Background Maize is a good model system for cereal crop genetics and development because of its rich genetic heritage and well-characterized morphology. The sequencing of its genome is well advanced, and new technologies for efficient proteomic analysis are needed. Baculovirus expression systems have been used for the last twenty years to express in insect cells a wide variety of eukaryotic proteins that require complex folding or extensive posttranslational modification. More recently, baculovirus display technologies based on the expression of foreign sequences on the surface of Autographa californica (AcMNPV have been developed. We investigated the potential of a display methodology for a cDNA library of maize young seedlings. Results We constructed a full-length cDNA library of young maize etiolated seedlings in the transfer vector pAcTMVSVG. The library contained a total of 2.5 × 105 independent clones. Expression of two known maize proteins, calreticulin and auxin binding protein (ABP1, was shown by western blot analysis of protein extracts from insect cells infected with the cDNA library. Display of the two proteins in infected insect cells was shown by selective biopanning using magnetic cell sorting and demonstrated proof of concept that the baculovirus maize cDNA display library could be used to identify and isolate proteins. Conclusion The maize cDNA library constructed in this study relies on the novel technology of baculovirus display and is unique in currently published cDNA libraries. Produced to demonstrate proof of principle, it opens the way for the development of a eukaryotic in vivo display tool which would be ideally suited for rapid screening of the maize proteome for binding partners, such as proteins involved in hormone regulation or defence.

Topic maps standard and its application in library and information science

Directory of Open Access Journals (Sweden)

Fatemeh Baji

2014-09-01

Full Text Available Topic maps are an ISO standard (ISO 13250 that is used for presenting the information about information resources structures. The initial idea of this standard was raised in 1991 and due to its strength; it turned into an ISO standard. This paper investigates concepts and model of topic maps and aims to mention applications of this standard in library and information science (LIS realm. A topic map, as a type of document is defined as XML or SGML technically. Research show that this standard is compatible with some of LIS techniques and rules especially in knowledge organization, but it attempts to use these rules in the web. So it can be said that according to some challenges that LIS field faces in adapting traditional techniques for knowledge organization in the Web, topic maps standard can help in solving such problems and challenges and this is what some experts of LIS tried to do.

Developing Archive Information Packages for Data Sets: Early Experiments with Digital Library Standards

Science.gov (United States)

Duerr, R. E.; Yang, M.; Gooyabadi, M.; Lee, C.

2008-12-01

The key to interoperability between systems is often metadata, yet metadata standards in the digital library and data center communities have evolved separately. In the data center world NASA's Directory Interchange Format (DIF), the Content Standard for Digital Geospatial Metadata (CSDGM), and most recently the international Geographic Information: Metadata (ISO 19115:2003) are used for descriptive metadata at the data set level to allow catalog interoperability; but use of anything other than repository- based metadata standards for the individual files that comprise a data set is rare, making true interoperability, at the data rather than data set level, across archives difficult. While the Open Archival Information Systems (OAIS) Reference Model with its call for creating Archive Information Packages (AIP) containing not just descriptive metadata but also preservation metadata is slowly being adopted in the community, the PREservation Metadata Implementation Strategies (PREMIS) standard, the only extant OAIS- compliant preservation metadata standard, has scarcely even been recognized as being applicable to the community. The digital library community in the meantime has converged upon the Metadata Encoding and Transmission Standard (METS) for interoperability between systems as evidenced by support for the standard by digital library systems such as Fedora and Greenstone. METS is designed to allow inclusion of other XML-based standards as descriptive and administrative metadata components. A recent Stanford study suggests that a combination of METS with included FGDC and PREMIS metadata could work well for individual granules of a data set. However, some of the lessons learned by the data center community over the last 30+ years of dealing with digital data are 1) that data sets as a whole need to be preserved and described and 2) that discovery and access mechanisms need to be hierarchical. Only once a user has reviewed a data set description and determined

A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells.

Science.gov (United States)

Park, Seonmi; Gianotti-Sommer, Andreia; Molina-Estevez, Francisco Javier; Vanuytsel, Kim; Skvir, Nick; Leung, Amy; Rozelle, Sarah S; Shaikho, Elmutaz Mohammed; Weir, Isabelle; Jiang, Zhihua; Luo, Hong-Yuan; Chui, David H K; Figueiredo, Maria Stella; Alsultan, Abdulraham; Al-Ali, Amein; Sebastiani, Paola; Steinberg, Martin H; Mostoslavsky, Gustavo; Murphy, George J

2017-04-11

Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated a diverse, comprehensive, and fully characterized library of sickle-cell-disease-specific induced pluripotent stem cells (iPSCs) from patients of different ethnicities, β-globin gene (HBB) haplotypes, and fetal hemoglobin (HbF) levels. iPSCs stand to revolutionize the way we study human development, model disease, and perhaps eventually, treat patients. Here, we describe this unique resource for the study of sickle cell disease, including novel haplotype-specific polymorphisms that affect disease severity, as well as for the development of patient-specific therapeutics for this phenotypically diverse disorder. As a complement to this library, and as proof of principle for future cell- and gene-based therapies, we also designed and employed CRISPR/Cas gene editing tools to correct the sickle hemoglobin (HbS) mutation. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Research Library

Science.gov (United States)

Los Alamos National Laboratory Research Library Search Site submit Contact Us | Remote Access Standards Theses/Dissertations Research Help Subject Guides Library Training Video Tutorials Alerts Research Library: delivering essential knowledge services for national security sciences since 1947 Los

Standards for University Libraries = Normes pour les bibliotheques universitaires = Richtwerte fur Universitatsbibliotheken = Normas de bibliotecas universitarias. IFLA Professional Reports No. 10.

Science.gov (United States)

Lynch, Beverly P., Ed.

This statement prepared by the International Federation of Library Associations' Section of University Libraries and Other General Research Libraries presents standards of general principles designed to accomplish the following: (1) provide a means by which the quality of the library serving a university can be assessed; (2) offer guidance for…

Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation.

Science.gov (United States)

Fan, Cuiqing; Xiong, Yuan; Zhu, Ning; Lu, Yabin; Zhang, Jiewen; Wang, Song; Liang, Zicai; Shen, Yan; Chen, Meihong

2011-03-01

Cancers are characterized by poor differentiation. Differentiation therapy is a strategy to alleviate malignant phenotypes by inducing cancer cell differentiation. Here we carried out a combinatorial high-throughput screen with a random siRNA library on human erythroleukemia K-562 cell differentiation. Two siRNAs screened from the library were validated to be able to induce erythroid differentiation to varying degrees, determined by CD235 and globin up-regulation, GATA-2 down-regulation, and cell growth inhibition. The screen we performed here is the first trial of screening cancer differentiation-inducing agents from a random siRNA library, demonstrating that a random siRNA library can be considered as a new resource in efforts to seek new therapeutic agents for cancers. As a random siRNA library has a broad coverage for the entire genome, including known/unknown genes and protein coding/non-coding sequences, screening using a random siRNA library can be expected to greatly augment the repertoire of therapeutic siRNAs for cancers.

mr. A C++ library for the matching and running of the Standard Model parameters

International Nuclear Information System (INIS)

Kniehl, Bernd A.; Veretin, Oleg L.; Pikelner, Andrey F.; Joint Institute for Nuclear Research, Dubna

2016-01-01

We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the MS renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

mr. A C++ library for the matching and running of the Standard Model parameters

Energy Technology Data Exchange (ETDEWEB)

Kniehl, Bernd A.; Veretin, Oleg L. [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Pikelner, Andrey F. [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Joint Institute for Nuclear Research, Dubna (Russian Federation). Bogoliubov Lab. of Theoretical Physics

2016-01-15

We present the C++ program library mr that allows us to reliably calculate the values of the running parameters in the Standard Model at high energy scales. The initial conditions are obtained by relating the running parameters in the MS renormalization scheme to observables at lower energies with full two-loop precision. The evolution is then performed in accordance with the renormalization group equations with full three-loop precision. Pure QCD corrections to the matching and running are included through four loops. We also provide a Mathematica interface for this program library.

Public libraries in the library regions in the year 2009

Directory of Open Access Journals (Sweden)

Milena Bon

2011-01-01

Full Text Available Purpose: Regional public libraries were initiated in 2003 to connect professional activities of libraries within regional networks and to ensure coordinated library development in a region in cooperation with the Library System Development Centre at the National and University Library performing a coordinating role. The article analyses the performance of public libraries and their integration in regional library networks in order to find out the level of development of conditions of performance of public libraries.Methodology/approach: Statistical data for the year 2009 were the basis for the overview of library activities of ten library regions with regard to applicable legislation and library standards. The level of regional library activities is compared to the socio-economic situation of statistical regions thus representing a new approach to the presentation of Slovenian’s public libraries’ development.Results: Absolute values indicate better development of nine libraries in the central Slovenia region while relative values offer a totally different picture. Four libraries in the region of Nova Gorica prove the highest level of development.Research limitation: Research is limited to the year 2009 and basic statistical analysis.Originality/practical implications: Findings of the analysis are useful for public libraries to plan their development strategy within a region and for financial bodies to provide for adequate financing for library activities in a specific region. The basic condition for successful public library performance is the even and harmonized development of conditions of performance as recommended by library standards.

ENDF/B-5 Standards Data Library (including modifications made in 1986). Summary of contents and documentation

International Nuclear Information System (INIS)

DayDay, N.; Lemmel, H.D.

1986-01-01

This document summarizes the contents and documentation of the ENDF/B-5 Standards Data Library (EN5-ST) released in September 1979. The library contains complete evaluations for all significant neutron reactions in the energy range 10 -5 eV to 20 MeV for H-1, He-3, Li-6, B-10, C-12, Au-197 and U-235 isotopes. In 1986 the files for C-12, Au-197 and U-235 were slightly modified. The entire library or selective retrievals from it can be obtained free of charge from the IAEA Nuclear Data Section. (author)

ENDF/B-5 Standards Data Library (including modifications made in 1986). Summary of contents and documentation

Energy Technology Data Exchange (ETDEWEB)

DayDay, N; Lemmel, H D

1986-05-01

This document summarizes the contents and documentation of the ENDF/B-5 Standards Data Library (EN5-ST) released in September 1979. The library contains complete evaluations for all significant neutron reactions in the energy range 10{sup -5}eV to 20 MeV for H-1, He-3, Li-6, B-10, C-12, Au-197 and U-235 isotopes. In 1986 the files for C-12, Au-197 and U-235 were slightly modified. The entire library or selective retrievals from it can be obtained free of charge from the IAEA Nuclear Data Section. (author) Refs, figs, tabs

Up to date cross sections library for Thermos and Record codes

International Nuclear Information System (INIS)

Hernandez Lopez, H.

1993-01-01

Reactor cell analysis is the first step in determining reactor core behavior and is required in the reload licensing process. For best results, reactor cell analysis should be carried out with libraries of up to date, accurate cross sections produced with well described methods from standard evaluated nuclear data. At first step in this work were determined the library structure for RECORD and THERMOS and were prepared the cross sections libraries using the NJOY nuclear data processing system and the ENDF-B/IV evaluated nuclear data. These libraries were used by the codes and some samples were perform, the result show some differences against the results obtained using the previous libraries. By other hand the libraries contain various adjustments to correct for deficiencies in nuclear data or analytical methods. These adjustments doesn't have any documentation, although some of them were identified in this work. (Author). 25 refs, 78 figs, 55 tabs

IAEA nuclear data for applications: Cross section standards and the reference input parameter library (RIPL)

International Nuclear Information System (INIS)

Capote Noy, Roberto; Nichols, Alan L.; Pronyaev, Vladimir G.

2003-01-01

An integral part of the activities of the IAEA Nuclear Data Section involves the development of nuclear data for a wide range of user applications. When considering low-energy nuclear reactions induced by neutrons, photons and charged particles, a detailed knowledge is required of the production cross sections over a wide energy range, spectra of emitted particles and their angular distributions. Two highly relevant IAEA data development projects are considered in this paper. Neutron reaction cross-section standards represent the basic quantities needed in nuclear reaction cross-section measurements and evaluations. These standards and the covariance matrices of their uncertainties were previously evaluated and released in 1987. However, the derived uncertainties were subsequently considered to be unrealistic low due to the effect of the low uncertainties obtained in fitting the light element standards to the R-matrix model; as a result, evaluators were forced to scale up the uncertainties to 'expected values'. An IAEA Coordinated Research Project (CRP) entitled 'Improvement of the Standard Cross Sections for Light Elements' was initiated in 2002 to improve the evaluation methodology for the covariance matrix of uncertainty in the R-matrix model fits, and to produce R-matrix evaluations of the important light element standards. The scope of this CRP has been substantially extended to include the preparation of a full set of evaluated standard reactions and covariance matrices of their uncertainties. While almost all requests for nuclear data were originally addressed through measurement programmes, our theoretical understanding of nuclear phenomena has reached a reasonable degree of reliability and nuclear modeling has become standard practice in nuclear data evaluations (with measurements remaining crucial for data testing and benchmarking). Since nuclear model codes require a considerable amount of numerical input, the IAEA has instigated extensive efforts to

Guide to LIBXSIF, a Library for Parsing the Extended Standard Input Format of Accelerated Beamlines(LCC-0060)

International Nuclear Information System (INIS)

Tenenbaum, P

2003-01-01

We describe LIBXSIF, a standalone library for parsing the Extended Standard Input Format of accelerator beamlines. Included in the description are: documentation of user commands; full description of permitted accelerator elements and their attributes; the construction of beamline lists; the mechanics of adding LIBXSIF to an existing program; and ''under the hood'' details for users who wish to modify the library or are merely morbidly curious

News from the Library

CERN Multimedia

CERN Library

2010-01-01

A third of the world’s current literature in electrical engineering is available on your CERN desktop Looking for a technical standard on software reviews and audits? Is it referred to as "IEEE color books"? Want to download and read NOW the latest version of IEEE 802? Whenever a need for a technical standard or specification arises in your activity, the Library is here to serve you. For IEEE standards it is particularly easy; the whole collection is available for immediate download. Indeed, since 2007, the CERN Library offers readers online access to the complete IEEE Electronic Library (Institute of Electrical and Electronics Engineers). This licence gives unlimited online access to all IEEE and IET journals and proceedings, starting from the first issue. But not everyone knows that this resource gives also access to all current IEEE standards as well as a selection of archival ones. The Library is now working on the integration of a selection of these standards in our onlin...

Evaluation of Standard Concepts Design of Library Interior Physical Environment (Case Study at University of Ma Chung

Directory of Open Access Journals (Sweden)

Debri Haryndia Putri

2016-12-01

Full Text Available Currently the function of a room is not only used as a shelter, the function of the room itself to be increased as a refreshing or relaxation area for users to follow the development of creativity and technology in the field of design. The comfortable factor becomes the main factor that indicates a successful process of creating a space. No exception library. The nature of library seemed stiff because of its function as a place to read, now can be developed and made into more dynamic with the special design concepts or color patterns used. Libraries can be created a special concept that suits the characteristics of the users themselves. Most users of the library, especially in college libraries are teenagers. Naturally, teenagers like to gather with their friends and we have to facilitate this activity in our library design concept. In addition we can also determine the needs of users through research by questionnaire method. The answers of users can be mapped and drawn conclusions. To explore the research, the author reviewed some literature about library interior design and observed the library of Ma Chung University as a case study. The combined results of the method can be concluded and the discovery of ideal standards of physical environment. So, the library can be made as a comfortable reading environment so as to increased interest in reading behavior and the frequent visits of students in the library.

Close the Textbook & Open "The Cell: An Image Library"

Science.gov (United States)

Saunders, Cheston; Taylor, Amy

2014-01-01

Many students leave the biology classroom with misconceptions centered on cellular structure. This article presents an activity in which students utilize images from an online database called "The Cell: An Image Library" (http://www.cellimagelibrary. org/) to gain a greater understanding of the diversity of cellular structure and the…

RFID in libraries a step toward interoperability

CERN Document Server

Ayre, Lori Bowen

2012-01-01

The approval by The National Information Standards Organization (NISO) of a new standard for RFID in libraries is a big step toward interoperability among libraries and vendors. By following this set of practices and procedures, libraries can ensure that an RFID tag in one library can be used seamlessly by another, assuming both comply, even if they have different suppliers for tags, hardware, and software. In this issue of Library Technology Reports, Lori Bowen Ayre, an experienced implementer of automated materials handling systems, Provides background on the evolution of the standard

Standards and Protocols for Digital Libraries Dijital Kütüphanelerde Standartlar ve Protokoller

Directory of Open Access Journals (Sweden)

Mehmet Emin Küçük

2003-06-01

Full Text Available New paradigms have been emerged in the field of librarianship and publishing with the developments in electronic environment, and rapid increase in electronically archived information and its acquisition and retrieval. While libraries show more interest in electronic information, publishers' current tendency is towards production of electronic information. In addition to the acquisition of electronic information, libraries have begun to digitise some of the holdings which do not present copyright problems. Economies provided by digitised information in terms of archiving, sharing and retrieval as well as the users' requirements are the basic motivation for digitisation. However, digital library standards have vital roles in performing effective library cooperation and interoperability between the systems. In this descriptive study, "the most commonly" confronted standards in digital library applications are being examined and evaluated under the following headings; (i record structure standards, (ii encoding standards, and (iii communication standards and protocols. However, metadata standards which can be categorised in record structure standards are not included since the matters are well studied in several papers in Turkish. Elektronik ortamdaki gelişmeler ve elektronik ortamda depolanan bilginin artmasıyla bilginin sağlanması, depolanması ve erişimi konularında önemli değişiklikler meydana gelmiş, yayıncılık ve kütüphanecilikte yeni paradigmaların oluşmasına neden olmuştur. Yayıncılar kaynakları elektronik ortamda üretme eğilimi göstermeye başlarken kütüphaneler de elektronik kaynaklara daha çok ilgi gösterir olmuşlardır. Elektronik ortamda üretilen kaynakların sağlanmasının yanı sıra, bir dizi kütüphane, dermelerinde bulunan ve telif sorunu olmayan materyali dijitalle sürerek kullanıcılarının hizmetine sunmaya başlamıştır. Dijital ortamda bilginin çok daha rahat depolanması, payla

Library Information-Processing System

Science.gov (United States)

1985-01-01

System works with Library of Congress MARC II format. System composed of subsystems that provide wide range of library informationprocessing capabilities. Format is American National Standards Institute (ANSI) format for machine-readable bibliographic data. Adaptable to any medium-to-large library.

Standards of Practice for West African Libraries; Proceedings of a Seminar Held at the Institute of Librarianship, University of Ibadan, 15-16 April 1967.

Science.gov (United States)

Dean, John, Ed.

A seminar on standards for libraries in West Africa was held in April 1967. This proceedings volume presents the papers given by each of the participants. Discussed are the standards for collections, facilities, staff, technical processes and services for public, school, university and special libraries. The purpose was to focus upon the nature,…

The use of GSM (cell-phone) in the library by surdents of Abubakar ...

African Journals Online (AJOL)

Results showed that students used the cell-phone mainly for communication purposes, to check time, send text messages, browsing internet, among other things. Cell-phone use in the library caused distraction and made concentration difficult. Recommendations were offered towards reducing use of cell-phone in the ...

Rapid isolation of antibody from a synthetic human antibody library by repeated fluorescence-activated cell sorting (FACS.

Directory of Open Access Journals (Sweden)

Sung Sun Yim

Full Text Available Antibodies and their derivatives are the most important agents in therapeutics and diagnostics. Even after the significant progress in the technology for antibody screening from huge libraries, it takes a long time to isolate an antibody, which prevents a prompt action against the spread of a disease. Here, we report a new strategy for isolating desired antibodies from a combinatorial library in one day by repeated fluorescence-activated cell sorting (FACS. First, we constructed a library of synthetic human antibody in which single-chain variable fragment (scFv was expressed in the periplasm of Escherichia coli. After labeling the cells with fluorescent antigen probes, the highly fluorescent cells were sorted by using a high-speed cell sorter, and these cells were reused without regeneration in the next round of sorting. After repeating this sorting, the positive clones were completely enriched in several hours. Thus, we screened the library against three viral antigens, including the H1N1 influenza virus, Hepatitis B virus, and Foot-and-mouth disease virus. Finally, the potential antibody candidates, which show K(D values between 10 and 100 nM against the target antigens, could be successfully isolated even though the library was relatively small (∼ 10(6. These results show that repeated FACS screening without regeneration of the sorted cells can be a powerful method when a rapid response to a spreading disease is required.

Layout level design for testability strategy applied to a CMOS cell library

NARCIS (Netherlands)

Blom, F.C.; Oliver, J.; Rullan, M.; Ferrer, C.

1993-01-01

The layout level design for testability (LLDFT) rules used here allow to avoid some hard to detect faults or even undetectable faults on a cell library by modifying the cell layout without changing their behavior and achieving a good level of reliability. These rules avoid some open faults or reduce

  Cell Penetrating Peptoids (CPPos: Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

Directory of Open Access Journals (Sweden)

Dominik K. Kölmel

2012-11-01

Full Text Available Cell penetrating peptoids (CPPos are potent mimics of the corresponding cell penetrating peptides (CPPs. The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of novel CPPos, which can be used to either target different cellular organelles or even different tissues and organs. In this study we established the submonomer-based solid phase synthesis of a “proof of principle” peptoid library in IRORI MiniKans to expand the amount for phenotypic high throughput screens of CPPos. The library consisting of tetrameric peptoids [oligo(N-alkylglycines] was established on Rink amide resin in a split and mix approach with hydrophilic and hydrophobic peptoid side chains. All CPPos of the presented library were labeled with rhodamine B to allow for the monitoring of cellular uptake by fluorescent confocal microscopy. Eventually, all the purified peptoids were subjected to live cell imaging to screen for CPPos with organelle specificity. While highly charged CPPos enter the cells by endocytosis with subsequent endosomal release, critical levels of lipophilicity allow other CPPos to specifically localize to mitochondria once a certain lipophilicity threshold is reached.

Harmonizing Library Statistics from Different Countries

DEFF Research Database (Denmark)

Hoel, Ivar A. L.

a Nordic Adaptation of the International Standard for Intaernational Library Statistics (ISO 2789) (14-STAT-1-E)......a Nordic Adaptation of the International Standard for Intaernational Library Statistics (ISO 2789) (14-STAT-1-E)...

Complementation of radiation-sensitive Ataxia telangiectasia cells after transfection of cDNA expression libraries and cosmid clones from wildtype cells

International Nuclear Information System (INIS)

Fritz, E.

1994-06-01

In this Ph.D.-thesis, phenotypic complementation of AT-cells (AT5BIVA) by transfection of cDNA-expression-libraries was adressed: After stable transfection of cDNA-expression-libraries G418 resistant clones were selected for enhanced radioresistance by a fractionated X-ray selection. One surviving transfectant clone (clone 514) exhibited enhanced radiation resistance in dose-response experiments and further X-ray selections. Cell cycle analysis revealed complementation of untreated and irradiated 514-cells in cell cycle progression. The rate of DNA synthesis, however, is not diminished after irradiation but shows the reverse effect. A transfected cDNA-fragment (AT500-cDNA) was isolated from the genomic DNA of 514-cells and proved to be an unknown DNA sequence. A homologous sequence could be detected in genomic DNA from human cell lines, but not in DNA from other species. The cDNA-sequence could be localized to human chromosome 11. In human cells the cDNA sequence is part of two large mRNAs. 4 different cosmid clones containing high molecular genomic DNA from normal human cells could be isolated from a library, each hybridizing to the AT500-cDNA. After stable transfection into AT-cells, one cosmid-clone was able to confer enhanced radiation resistance both in X-ray selections and dose-response experiments. The results indicate that the cloned cDNA-fragment is based on an unknown gene from human chromosome 11 which partially complements the radiosensitivity and the defective cell cycle progression in AT5BIVA cells. (orig.) [de

An efficient auto TPT stitch guidance generation for optimized standard cell design

Science.gov (United States)

Samboju, Nagaraj C.; Choi, Soo-Han; Arikati, Srini; Cilingir, Erdem

2015-03-01

As the technology continues to shrink below 14nm, triple patterning lithography (TPT) is a worthwhile lithography methodology for printing dense layers such as Metal1. However, this increases the complexity of standard cell design, as it is very difficult to develop a TPT compliant layout without compromising on the area. Hence, this emphasizes the importance to have an accurate stitch generation methodology to meet the standard cell area requirement as defined by the technology shrink factor. In this paper, we present an efficient auto TPT stitch guidance generation technique for optimized standard cell design. The basic idea here is to first identify the conflicting polygons based on the Fix Guidance [1] solution developed by Synopsys. Fix Guidance is a reduced sub-graph containing minimum set of edges along with the connecting polygons; by eliminating these edges in a design 3-color conflicts can be resolved. Once the conflicting polygons are identified using this method, they are categorized into four types [2] - (Type 1 to 4). The categorization is based on number of interactions a polygon has with the coloring links and the triangle loops of fix guidance. For each type a certain criteria for keep-out region is defined, based on which the final stitch guidance locations are generated. This technique provides various possible stitch locations to the user and helps the user to select the best stitch location considering both design flexibility (max. pin access/small area) and process-preferences. Based on this technique, a standard cell library for place and route (P and R) can be developed with colorless data and a stitch marker defined by designer using our proposed method. After P and R, the full chip (block) would contain the colorless data and standard cell stitch markers only. These stitch markers are considered as "must be stitch" candidates. Hence during full chip decomposition it is not required to generate and select the stitch markers again for the

An Analysis of the Impact of Federated Search Products on Library Instruction Using the ACRL Standards

Science.gov (United States)

Cox, Christopher

2006-01-01

Federated search products are becoming more and more prevalent in academic libraries. What are the implications of this phenomenon for instruction librarians? An analysis of federated search products using the "Information Literacy Competency Standards for Higher Education" and a thorough review of the literature offer insight concerning whether…

THERMLIB, Generator and Edit of Program THERMOS-OTA Library. THERLIB, Library Generated for THERMOS from FACEL Library

International Nuclear Information System (INIS)

Rastas, A.

1985-01-01

1 - Description of problem or function: THERMLIB is a code that generates, revises and expands the input data library to the lattice cell code THERMOS-OTA. It can be used to: - create an entirely new library; - modify the data of library materials, remove materials, add materials; - list the library. 2 - Restrictions on the complexity of the problem: Max. of 30 materials may be modified or removed. Max. of 30 new materials may be created. Max. of 50 velocity groups

German Librarianship and Munich Libraries

Directory of Open Access Journals (Sweden)

Osman Ümit Özen

1994-06-01

Full Text Available There are 27 municipal libraries including the Central Public Library in Munich. The other important libraries in the city are Bayern State National Library, Maximillian University Library, a technical highschool library and the "Deutsches Musuem" Library. All these libraries are financed locally. The author introduces these libraries briefly and compares German libraries with Turkish libraries. He concludes that although theoretically there are not distinctive differences, in practice, buildings and their layout are better in Germany where more variety of services are offered. In Turkey standardization has not been realized yet. Turkey needs to computerize and network to improve the services offered in an efficient way.

Assessment of a 42 metal salts chemical library in mouse embryonic stem cells

Science.gov (United States)

The developmental effects of xenobiotics on differentiation can be profiled using mouse embryonic stem cells (mESCs). The adherent cell differentiation and cytotoxicity (ACDC) technique was used to evaluate a library of 42 metal and metaloid salts. Jl mESCs were allowed to prolif...

Construction of a cDNA library from human retinal pigment epithelial cells challenged with rod outer segments.

Science.gov (United States)

Cavaney, D M; Rakoczy, P E; Constable, I J

1995-05-01

To study genes expressed by retinal pigment epithelial (RPE) cells during phagocytosis and digestion of rod outer segments (ROS), a complementary (c)DNA library was produced using an in-vitro model. The cDNA library can be used to study molecular changes which contribute to the development of diseases due to a failure in outer segment phagocytosis and digestion by RPE cells. Here we demonstrate a way to study genes and their functions using a molecular biological approach and describing the first step involved in this process, the construction of a cDNA library. Human RPE cells obtained from the eyes of a seven-year-old donor were cultured and challenged with bovine ROS. The culture was harvested and total RNA was extracted. Complementary DNA was transcribed from the messenger (m)RNA and was directionally cloned into the LambdaGEM-4 bacteriophage vector successfully. Some clones were picked and the DNA extracted, to determine the size of the inserts as a measure of the quality of the library. Molecular biology and cell culture are important tools to be used in eye research, especially in areas where tissue is limiting and animal models are not available. We now have a ROS challenged RPE cDNA library which will be used to identify genes responsible for degrading phagocytosed debris within the retinal pigment epithelium.

Definition and denomination of occupations in libraries

Directory of Open Access Journals (Sweden)

Jelka Gazvoda

1998-01-01

Full Text Available In the first part of the article, the author presents the modern definition of occupation as defined in the ISCO-88 standard, and consecutively in the Slovenian Standard Classification of Occupations; occupations in the field of library and information science are then placed in a wider frame of information occupations which are present in ali spheres of activities. The following part of the article is focused on information occupations in libraries, especially on their contents definitions and denominations.Based on the analysis of job descriptions in three Slovenian libraries (National and University Library, University Library of Maribor and Central Technical Library,the author came to the following conclusion: the existent practice in libraries shows that the contents and denominations of occupations in library and information jobs are defined too loosely. In most cases, the contents of occupation is defined by the contents of the job, while for its denomination the required educational title of the employee is often used. Therefore, the author proposes the establishment of a work force which would define the contents and design denominations to library and information occupations according to the principles contained in the Standard Classification of Occupations.

UFMGLIB: a multigroup library for the WIMS code

International Nuclear Information System (INIS)

Aboustta, Mohamed A.; Mello, Jair Carlos

1995-01-01

The British code WIMS is distributed by the NEA in its D4 version. It has a proper data library (Standard Library) in 69 energy groups covering, in its 1981 version, more than 100 materials with sufficient details. The Standard library was generated, basically, from the UKNDL data files and has been submitted to many alterations since the 1960's. Completely new versions such as the WIMKAL 88, generated from the basic library ENDF/B-V, were introduced and are available from the IAEA. The library UFMGLIB was generated from the ENDF/B-VI basic data library with some of the Standard data being maintained. The library contains evaluations for 131 different materials including the most common in thermal reactors. Results obtained from running the WIMS-D4 code with this library compare very well with results from the other libraries when running benchmark cases. This paper shows a general description of the library and some of the steps taken to generate it. (author). 12 refs, 2 tabs

Voro++: a three-dimensional Voronoi cell library in C++

Energy Technology Data Exchange (ETDEWEB)

Rycroft, Chris

2009-01-15

Voro++ is a free software library for the computation of three dimensional Voronoi cells. It is primarily designed for applications in physics and materials science, where the Voronoi tessellation can be a useful tool in the analysis of densely-packed particle systems, such as granular materials or glasses. The software comprises of several C++ classes that can be modified and incorporated into other programs. A command-line utility is also provided that can use most features of the code. Voro++ makes use of a direct cell-by-cell construction, which is particularly suited to handling special boundary conditions and walls. It employs algorithms which are tolerant for numerical precision errors, and it has been successfully employed on very large particle systems.

[Construction of fetal mesenchymal stem cell cDNA subtractive library].

Science.gov (United States)

Yang, Li; Wang, Dong-Mei; Li, Liang; Bai, Ci-Xian; Cao, Hua; Li, Ting-Yu; Pei, Xue-Tao

2002-04-01

To identify differentially expressed genes between fetal mesenchymal stem cell (MSC) and adult MSC, especially specified genes expressed in fetal MSC, a cDNA subtractive library of fetal MSC was constructed using suppression subtractive hybridization (SSH) technique. At first, total RNA was isolated from fetal and adult MSC. Using SMART PCR synthesis method, single-strand and double-strand cDNAs were synthesized. After Rsa I digestion, fetal MSC cDNAs were divided into two groups and ligated to adaptor 1 and adaptor 2 respectively. Results showed that the amplified library contains 890 clones. Analysis of 890 clones with PCR demonstrated that 768 clones were positive. The positive rate is 86.3%. The size of inserted fragments in these positive clones was between 0.2 - 1 kb, with an average of 400 - 600 bp. SSH is a convenient and effective method for screening differentially expressed genes. The constructed cDNA subtractive library of fetal MSC cDNA lays solid foundation for screening and cloning new and specific function related genes of fetal MSC.

12G: code for conversion of isotope-ordered cross-section libraries into group-ordered cross-section libraries

International Nuclear Information System (INIS)

Resnik, W.M. II; Bosler, G.E.

1977-09-01

Many current reactor physics codes accept cross-section libraries in an isotope-ordered form, convert them with internal preprocessing routines to a group-ordered form, and then perform calculations using these group-ordered data. Occasionally, because of storage and time limitations, the preprocessing routines in these codes cannot convert very large multigroup isotope-ordered libraries. For this reason, the I2G code, i.e., ISOTXS to GRUPXS, was written to convert externally isotope-ordered cross section libraries in the standard file format called ISOTXS to group-ordered libraries in the standard format called GRUPXS. This code uses standardized multilevel data management routines which establish a strategy for the efficient conversion of large libraries. The I2G code is exportable contingent on access to, and an intimate familiarization with, the multilevel routines. These routines are machine dependent, and therefore must be provided by the importing facility. 6 figures, 3 tables

Evaluation of molecular markers for Phytophthora ramorum detection and identification using a standardized library of isolates

Science.gov (United States)

F.N. Martin; M. Coffey; R. Hamelin; P. Tooley; M. Garbelotto; K. Hughes; T. Kubisiak

2008-01-01

A number of molecular diagnostic procedures for detection of Phytophthora ramorum have been reported in the literature. In an effort to evaluate the specificity of 10 of these techniques a standardized DNA library for 317 isolates was assembled that included 60 described species as well as 22 taxonomically unclassified isolates. These were sent blind...

ALL-Digital Baseband 65nm PLL/FPLL Clock Multiplier Using 10-Cell Library

Science.gov (United States)

Schuler, Robert L., Jr.; Wu, Qiong; Liu, Rui; Chen, Li; Madala, Shridhar

2014-01-01

PLLs for clock generation are essential for modern circuits, to generate specialized frequencies for many interfaces and high frequencies for chip internal operation. These circuits depend on analog circuits and careful tailoring for each new process, and making them fault tolerant is an incompletely solved problem. Until now, all digital PLLs have been restricted to sampled data DSP techniques and not available for the highest frequency baseband applications. This paper presents the design and preliminary evaluation of an all-digital baseband technique built entirely with an easily portable 10-cell digital library. The library is also described, as it aids in research and low volume design porting to new processes. The advantages of the digital approach are the wide variety of techniques available to give varying degrees of fault tolerance, and the simplicity of porting the design to new processes, even to exotic processes that may not have analog capability. The only tuning parameter is digital gate delay. An all-digital approach presents unique problems and standard analog loop stability design criteria cannot be directly used. Because of the quantization of frequency, there is effectively infinite gain for very small loop error feedback. The numerically controlled oscillator (NCO) based on a tapped delay line cannot be reliably updated while a pulse is active in the delay line, and ordinarily does not have enough frequency resolution for a low-jitter output.

A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

Science.gov (United States)

Connaway, Lynn Silipigni

2001-01-01

Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

[Review of digital ground object spectral library].

Science.gov (United States)

Zhou, Xiao-Hu; Zhou, Ding-Wu

2009-06-01

A higher spectral resolution is the main direction of developing remote sensing technology, and it is quite important to set up the digital ground object reflectance spectral database library, one of fundamental research fields in remote sensing application. Remote sensing application has been increasingly relying on ground object spectral characteristics, and quantitative analysis has been developed to a new stage. The present article summarized and systematically introduced the research status quo and development trend of digital ground object reflectance spectral libraries at home and in the world in recent years. Introducing the spectral libraries has been established, including desertification spectral database library, plants spectral database library, geological spectral database library, soil spectral database library, minerals spectral database library, cloud spectral database library, snow spectral database library, the atmosphere spectral database library, rocks spectral database library, water spectral database library, meteorites spectral database library, moon rock spectral database library, and man-made materials spectral database library, mixture spectral database library, volatile compounds spectral database library, and liquids spectral database library. In the process of establishing spectral database libraries, there have been some problems, such as the lack of uniform national spectral database standard and uniform standards for the ground object features as well as the comparability between different databases. In addition, data sharing mechanism can not be carried out, etc. This article also put forward some suggestions on those problems.

Robust Sub-nanomolar Library Preparation for High Throughput Next Generation Sequencing.

Science.gov (United States)

Wu, Wells W; Phue, Je-Nie; Lee, Chun-Ting; Lin, Changyi; Xu, Lai; Wang, Rong; Zhang, Yaqin; Shen, Rong-Fong

2018-05-04

Current library preparation protocols for Illumina HiSeq and MiSeq DNA sequencers require ≥2 nM initial library for subsequent loading of denatured cDNA onto flow cells. Such amounts are not always attainable from samples having a relatively low DNA or RNA input; or those for which a limited number of PCR amplification cycles is preferred (less PCR bias and/or more even coverage). A well-tested sub-nanomolar library preparation protocol for Illumina sequencers has however not been reported. The aim of this study is to provide a much needed working protocol for sub-nanomolar libraries to achieve outcomes as informative as those obtained with the higher library input (≥ 2 nM) recommended by Illumina's protocols. Extensive studies were conducted to validate a robust sub-nanomolar (initial library of 100 pM) protocol using PhiX DNA (as a control), genomic DNA (Bordetella bronchiseptica and microbial mock community B for 16S rRNA gene sequencing), messenger RNA, microRNA, and other small noncoding RNA samples. The utility of our protocol was further explored for PhiX library concentrations as low as 25 pM, which generated only slightly fewer than 50% of the reads achieved under the standard Illumina protocol starting with > 2 nM. A sub-nanomolar library preparation protocol (100 pM) could generate next generation sequencing (NGS) results as robust as the standard Illumina protocol. Following the sub-nanomolar protocol, libraries with initial concentrations as low as 25 pM could also be sequenced to yield satisfactory and reproducible sequencing results.

Flight Software Math Library

Science.gov (United States)

McComas, David

2013-01-01

The flight software (FSW) math library is a collection of reusable math components that provides typical math utilities required by spacecraft flight software. These utilities are intended to increase flight software quality reusability and maintainability by providing a set of consistent, well-documented, and tested math utilities. This library only has dependencies on ANSI C, so it is easily ported. Prior to this library, each mission typically created its own math utilities using ideas/code from previous missions. Part of the reason for this is that math libraries can be written with different strategies in areas like error handling, parameters orders, naming conventions, etc. Changing the utilities for each mission introduces risks and costs. The obvious risks and costs are that the utilities must be coded and revalidated. The hidden risks and costs arise in miscommunication between engineers. These utilities must be understood by both the flight software engineers and other subsystem engineers (primarily guidance navigation and control). The FSW math library is part of a larger goal to produce a library of reusable Guidance Navigation and Control (GN&C) FSW components. A GN&C FSW library cannot be created unless a standardized math basis is created. This library solves the standardization problem by defining a common feature set and establishing policies for the library s design. This allows the libraries to be maintained with the same strategy used in its initial development, which supports a library of reusable GN&C FSW components. The FSW math library is written for an embedded software environment in C. This places restrictions on the language features that can be used by the library. Another advantage of the FSW math library is that it can be used in the FSW as well as other environments like the GN&C analyst s simulators. This helps communication between the teams because they can use the same utilities with the same feature set and syntax.

An open-source library for the numerical modeling of mass-transfer in solid oxide fuel cells

Science.gov (United States)

Novaresio, Valerio; García-Camprubí, María; Izquierdo, Salvador; Asinari, Pietro; Fueyo, Norberto

2012-01-01

the simulation of the steady state mass and momentum transport in a multi-species gas mixture, possibly in a porous medium. The software is particularly designed to be used as the mass-transport library for the modeling of solid oxide fuel cells (SOFC). When supplemented with other sub-models, such as thermal and charge-transport ones, it allows the prediction of the cell polarization curve and hence the cell performance. Solution method: Standard finite volume method (FVM) is used for solving all the conservation equations. The pressure-velocity coupling is solved using the SIMPLE algorithm (possibly adding a porous drag term if required). The mass transport can be calculated using different alternative models, namely Fick, Maxwell-Stefan or dusty gas model. The code adopts a segregated method to solve the resulting linear system of equations. The different regions of the SOFC, namely gas channels, electrodes and electrolyte, are solved independently, and coupled through boundary conditions. Restrictions: When extremely large species fluxes are considered, current implementation of the Neumann and Robin boundary conditions do not avoid negative values of molar and/or mass fractions, which finally end up with numerical instability. However this never happened in the documented runs. Eventually these boundary conditions could be reformulated to become more robust. Running time: From seconds to hours depending on the mesh size and number of species. For example, on a 64 bit machine with Intel Core Duo T8300 and 3 GBytes of RAM, the provided test run requires less than 1 second.

Immune TB Antibody Phage Display Library as a Tool To Study B Cell Immunity in TB Infections.

Science.gov (United States)

Hamidon, Nurul Hamizah; Suraiya, Siti; Sarmiento, Maria E; Acosta, Armando; Norazmi, Mohd Nor; Lim, Theam Soon

2018-03-01

B cells and in particular antibodies has always played second fiddle to cellular immunity in regard to tuberculosis (TB). However, recent studies has helped position humoral immunity especially antibodies back into the foray in relation to TB immunity. Therefore, the ability to correlate the natural antibody responses of infected individuals toward TB antigens would help strengthen this concept. Phage display is an intriguing approach that can be utilized to study antibody-mediated responses against a particular infection via harvesting the B cell repertoire from infected individuals. The development of disease-specific antibody libraries or immune libraries is useful to better understand antibody-mediated immune responses against specific disease antigens. This study describes the generation of an immune single-chain variable fragment (scFv) library derived from TB-infected individuals. The immune library with an estimated diversity of 10 9 independent clones was then applied for the identification of monoclonal antibodies against Mycobacterium tuberculosis α-crystalline as a model antigen. Biopanning of the library isolated three monoclonal antibodies with unique gene usage. This strengthens the role of antibodies in TB immunity in addition to the role played by cellular immunity. The developed library can be applied against other TB antigens and aid antibody-derived TB immunity studies in the future.

Design of Concept Libraries for C++

KAUST Repository

Sutton, Andrew

2012-01-01

We present a set of concepts (requirements on template arguments) for a large subset of the ISO C++ standard library. The goal of our work is twofold: to identify a minimal and useful set of concepts required to constrain the library\\'s generic algorithms and data structures and to gain insights into how best to support such concepts within C++. We start with the design of concepts rather than the design of supporting language features; the language design must be made to fit the concepts, rather than the other way around. A direct result of the experiment is the realization that to simply and elegantly support generic programming we need two kinds of abstractions: constraints are predicates on static properties of a type, and concepts are abstract specifications of an algorithm\\'s syntactic and semantic requirements. Constraints are necessary building blocks of concepts. Semantic properties are represented as axioms. We summarize our approach: concepts = constraints + axioms. This insight is leveraged to develop a library containing only 14 concepts that encompassing the functional, iterator, and algorithm components of the C++ Standard Library (the STL). The concepts are implemented as constraint classes and evaluated using Clang\\'s and GCC\\'s Standard Library test suites. © 2012 Springer-Verlag.

Construction of C35 gene bait recombinants and T47D cell cDNA library.

Science.gov (United States)

Yin, Kun; Xu, Chao; Zhao, Gui-Hua; Liu, Ye; Xiao, Ting; Zhu, Song; Yan, Ge

2017-11-20

C35 is a novel tumor biomarker associated with metastasis progression. To investigate the interaction factors of C35 in its high expressed breast cancer cell lines, we constructed bait recombinant plasmids of C35 gene and T47D cell cDNA library for yeast two-hybrid screening. Full length C35 sequences were subcloned using RT-PCR from cDNA template extracted from T47D cells. Based on functional domain analysis, the full-length C35 1-348bp was also truncated into two fragments C351-153bp and C35154-348bp to avoid auto-activation. The three kinds of C35 genes were successfully amplified and inserted into pGBKT7 to construct bait recombinant plasmids pGBKT7-C351-348bp, pGBKT7-C351-153bp and pGBKT7-C35154-348bp, then transformed into Y187 yeast cells by the lithium acetate method. Auto-activation and toxicity of C35 baits were detected using nutritional deficient medium and X-α-Gal assays. The T47D cell ds cDNA was generated by SMART TM technology and the library was constructed using in vivo recombination-mediated cloning in the AH109 yeast strain using a pGADT7-Rec plasmid. The transformed Y187/pGBKT7-C351-348bp line was intensively inhibited while the truncated Y187/pGBKT7-C35 lines had no auto-activation and toxicity in yeast cells. The titer of established cDNA library was 2 × 10 7 pfu/mL with high transformation efficiency of 1.4 × 10 6 , and the insert size of ds cDNA was distributed homogeneously between 0.5-2.0 kb. Our research generated a T47D cell cDNA library with high titer, and the constructed two C35 "baits" contained a respective functional immunoreceptor tyrosine based activation motif (ITAM) and the conserved last four amino acids Cys-Ile-Leu-Val (CILV) motif, and therefore laid a foundation for screening the C35 interaction factors in a BC cell line.

Comprehensive evaluation and optimization of amplicon library preparation methods for high-throughput antibody sequencing.

Science.gov (United States)

Menzel, Ulrike; Greiff, Victor; Khan, Tarik A; Haessler, Ulrike; Hellmann, Ina; Friedensohn, Simon; Cook, Skylar C; Pogson, Mark; Reddy, Sai T

2014-01-01

High-throughput sequencing (HTS) of antibody repertoire libraries has become a powerful tool in the field of systems immunology. However, numerous sources of bias in HTS workflows may affect the obtained antibody repertoire data. A crucial step in antibody library preparation is the addition of short platform-specific nucleotide adapter sequences. As of yet, the impact of the method of adapter addition on experimental library preparation and the resulting antibody repertoire HTS datasets has not been thoroughly investigated. Therefore, we compared three standard library preparation methods by performing Illumina HTS on antibody variable heavy genes from murine antibody-secreting cells. Clonal overlap and rank statistics demonstrated that the investigated methods produced equivalent HTS datasets. PCR-based methods were experimentally superior to ligation with respect to speed, efficiency, and practicality. Finally, using a two-step PCR based method we established a protocol for antibody repertoire library generation, beginning from inputs as low as 1 ng of total RNA. In summary, this study represents a major advance towards a standardized experimental framework for antibody HTS, thus opening up the potential for systems-based, cross-experiment meta-analyses of antibody repertoires.

Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus

Directory of Open Access Journals (Sweden)

Tchitchek Nicolas

2012-06-01

Full Text Available Abstract Background African Green Monkeys (AGM are amongst the most frequently used nonhuman primate models in clinical and biomedical research, nevertheless only few genomic resources exist for this species. Such information would be essential for the development of dedicated new generation technologies in fundamental and pre-clinical research using this model, and would deliver new insights into primate evolution. Results We have exhaustively sequenced an Expression Sequence Tag (EST library made from a pool of Peripheral Blood Mononuclear Cells from sixteen Chlorocebus sabaeus monkeys. Twelve of them were infected with the Simian Immunodeficiency Virus. The mononuclear cells were or not stimulated in vitro with Concanavalin A, with lipopolysacharrides, or through mixed lymphocyte reaction in order to generate a representative and broad library of expressed sequences in immune cells. We report here 37,787 sequences, which were assembled into 14,410 contigs representing an estimated 12% of the C. sabaeus transcriptome. Using data from primate genome databases, 9,029 assembled sequences from C. sabaeus could be annotated. Sequences have been systematically aligned with ten cDNA references of primate species including Homo sapiens, Pan troglodytes, and Macaca mulatta to identify ortholog transcripts. For 506 transcripts, sequences were quasi-complete. In addition, 6,576 transcript fragments are potentially specific to the C. sabaeus or corresponding to not yet described primate genes. Conclusions The EST library we provide here will prove useful in gene annotation efforts for future sequencing of the African Green Monkey genomes. Furthermore, this library, which particularly well represents immunological and hematological gene expression, will be an important resource for the comparative analysis of gene expression in clinically relevant nonhuman primate and human research.

Library Locations

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours. The map below does not display...

The Weakest Link: Library Catalogs.

Science.gov (United States)

Young, Terrence E., Jr.

2002-01-01

Describes methods of correcting MARC records in online public access catalogs in school libraries. Highlights include in-house methods; professional resources; conforming to library cataloging standards; vendor services, including Web-based services; software specifically developed for record cleanup; and outsourcing. (LRW)

Parallel Computation on Multicore Processors Using Explicit Form of the Finite Element Method and C++ Standard Libraries

Directory of Open Access Journals (Sweden)

Rek Václav

2016-11-01

Full Text Available In this paper, the form of modifications of the existing sequential code written in C or C++ programming language for the calculation of various kind of structures using the explicit form of the Finite Element Method (Dynamic Relaxation Method, Explicit Dynamics in the NEXX system is introduced. The NEXX system is the core of engineering software NEXIS, Scia Engineer, RFEM and RENEX. It has the possibilities of multithreaded running, which can now be supported at the level of native C++ programming language using standard libraries. Thanks to the high degree of abstraction that a contemporary C++ programming language provides, a respective library created in this way can be very generalized for other purposes of usage of parallelism in computational mechanics.

enforcing tertiary school library rules and regulations

African Journals Online (AJOL)

2014-10-31

Oct 31, 2014 ... beings -library users/patrons. It is also a standard rule that library ... degree of criminal behaviors in the use of their resources (Momodu, 2002). It is also a well known fact that some individual users of academic libraries display disruptive or criminal behaviors within the library and this often poses security ...

E-Books and New Library Service Models: An Analysis of the Impact of E-Book Technology on Academic Libraries.

Science.gov (United States)

Jantz, Ronald

2001-01-01

Analyzes the implications of electronic book technology (e-books) on academic libraries. Discusses new business models for publishers, including self-publishing, Internet publishing, and partnerships with libraries as publishers; impact on library services, including cataloging, circulation, and digital preservation; user benefits; standards;…

Digital library research : current developments and trends

OpenAIRE

Shiri, Ali

2003-01-01

This column gives an overview of current trends in digital library research under the following headings: digital library architecture, systems, tools and technologies; digital content and collections; metadata; interoperability; standards; knowledge organisation systems; users and usability; legal, organisational, economic, and social issues in digital libraries.

School Libraries Empowering Learning: The Australian Landscape.

Science.gov (United States)

Todd, Ross J.

2003-01-01

Describes school libraries in Australia. Highlights include the title of teacher librarian and their education; the history of the role of school libraries in Australian education; empowerment; information skills and benchmarks; national standards for school libraries; information literacy; learning outcomes; evidence-based practice; digital…

Simulation of the burnup in cell calculation using the WIMSD-5B Code considering different nuclear data libraries

International Nuclear Information System (INIS)

Tavares, Desirée Yael de Sena; Silva, Adilson Costa da; Lima, Zelmo Rodrigues de

2017-01-01

This work proposes to implement the cell calculation considering the fuel burning using the WIMSD-5B code. The cell calculation procedure allows to determine the nuclear parameters present in the multi-group neutron diffusion equation and for this purpose the neutron transport theory is used in a problem with dimensional reduction, but in contrast is considered a large number of groups associated with the neutron spectrum. There are a variety of reactor physics codes that determine the nuclear parameters by solving the neutron transport equation applied to an equivalent cell representing a fuel element. The WIMSD-5B code is a deterministic code that solves the transport equation using collision probability method. The simulation of fuel burning in the cell calculation took into account different nuclear data libraries. The WIMSD-5B code supports several nuclear data libraries and in the present work the following libraries were used: IAEA, ENDFB-VII.1, JENDL3.2, JEFF3.1 and JEF2.2, all formatted for 69 energy groups. (author)

Simulation of the burnup in cell calculation using the WIMSD-5B Code considering different nuclear data libraries

Energy Technology Data Exchange (ETDEWEB)

Tavares, Desirée Yael de Sena; Silva, Adilson Costa da; Lima, Zelmo Rodrigues de, E-mail: zelmolima@yahoo.com.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2017-07-01

This work proposes to implement the cell calculation considering the fuel burning using the WIMSD-5B code. The cell calculation procedure allows to determine the nuclear parameters present in the multi-group neutron diffusion equation and for this purpose the neutron transport theory is used in a problem with dimensional reduction, but in contrast is considered a large number of groups associated with the neutron spectrum. There are a variety of reactor physics codes that determine the nuclear parameters by solving the neutron transport equation applied to an equivalent cell representing a fuel element. The WIMSD-5B code is a deterministic code that solves the transport equation using collision probability method. The simulation of fuel burning in the cell calculation took into account different nuclear data libraries. The WIMSD-5B code supports several nuclear data libraries and in the present work the following libraries were used: IAEA, ENDFB-VII.1, JENDL3.2, JEFF3.1 and JEF2.2, all formatted for 69 energy groups. (author)

Libraries and the Mobile Web

Science.gov (United States)

Hanson, Cody

2011-01-01

In 2011, cell phones and mobile devices are ubiquitous. The vast majority of Americans now own cell phones, and over half of them have mobile access to the Internet through a phone or other mobile device. For libraries to stay relevant, they must be able to offer content and services through the mobile web. In this issue of "Library Technology…

Gauging User Interest in Non-Traditional Library Resources

Energy Technology Data Exchange (ETDEWEB)

Sandberg, Tami; Abbott, Jennifer

2015-06-23

The National Renewable Energy Laboratory (NREL) is a government funded research laboratory based in Golden, Colorado. In addition to collecting traditional library resources such as journals, conference proceedings, and print and electronic books, the library also spends a significant portion of its collection development funds on resources not often found in many libraries: technical industry standards (e.g., ISO, IEC, ASTM, IEEE) and energy-related market reports. Assessing user needs for these resources is difficult for a number of reasons, particularly because standardized usage statistics are lacking or non-existent. Standards and market reports are generally costly and include fairly restrictive license agreements, which increase the importance of making informed collection development decisions. This presentation will discuss the NREL Library's current collection assessment and development practices as they relate to these unique resources.

Designing Collaborative Developmental Standards by Refactoring of the Earth Science Models, Libraries, Workflows and Frameworks.

Science.gov (United States)

Mirvis, E.; Iredell, M.

2015-12-01

The operational (OPS) NOAA National Centers for Environmental Prediction (NCEP) suite, traditionally, consist of a large set of multi- scale HPC models, workflows, scripts, tools and utilities, which are very much depending on the variety of the additional components. Namely, this suite utilizes a unique collection of the in-house developed 20+ shared libraries (NCEPLIBS), certain versions of the 3-rd party libraries (like netcdf, HDF, ESMF, jasper, xml etc.), HPC workflow tool within dedicated (sometimes even vendors' customized) HPC system homogeneous environment. This domain and site specific, accompanied with NCEP's product- driven large scale real-time data operations complicates NCEP collaborative development tremendously by reducing chances to replicate this OPS environment anywhere else. The NOAA/NCEP's Environmental Modeling Center (EMC) missions to develop and improve numerical weather, climate, hydrological and ocean prediction through the partnership with the research community. Realizing said difficulties, lately, EMC has been taken an innovative approach to improve flexibility of the HPC environment by building the elements and a foundation for NCEP OPS functionally equivalent environment (FEE), which can be used to ease the external interface constructs as well. Aiming to reduce turnaround time of the community code enhancements via Research-to-Operations (R2O) cycle, EMC developed and deployed several project sub-set standards that already paved the road to NCEP OPS implementation standards. In this topic we will discuss the EMC FEE for O2R requirements and approaches in collaborative standardization, including NCEPLIBS FEE and models code version control paired with the models' derived customized HPC modules and FEE footprints. We will share NCEP/EMC experience and potential in the refactoring of EMC development processes, legacy codes and in securing model source code quality standards by using combination of the Eclipse IDE, integrated with the

The Human Side of Libraries.

Science.gov (United States)

Surace, Cecily J.

This paper discusses current trends in personnel management, with emphasis on performance standards and employee evaluation. Advances in personnel management from the scientific management theory to the application of the "human side of enterprise" approach should be reflected in how library managers review personnel and operate their libraries.…

Evaluation of molecular markers for Phytophthora ramorum detection and identification: Testing for specificity using a standardized library of isolates

Science.gov (United States)

F.N. Martin; M.D. Coffey; K. Zeller; R.C. Hamelin; P. Tooley; M. Garbelotto; K.J.D. Hughes; T. Kubisiak; G.J. Bilodeau; L. Levy; C. Blomquist; P.H. Berger

2009-01-01

Given the importance of Phytophthora ramorum from a regulatory standpoint, it is imperative that molecular markers for pathogen detection are fully tested to evaluate their specificity in detection of the pathogen. In an effort to evaluate 11 reported diagnostic techniques, we assembled a standardized DNA library using accessions from the World...

Tuning of the Shower Library for the LHCb calorimeter fast simulation

CERN Document Server

Rabemananjara, Tanjona Radonirina

2016-01-01

The standard simulation of the LHCb detector uses the Geant4 simulation toolkit, which provides very accurate results but is CPU-expensive. A number of faster simulation options are available or under development. Among the latter, the replacement of the electromagnetic and hadronic showers simulation in the calorimeter with pre-simulated hit libraries is ongoing. My work has focused on the characterization of the particles reaching the calorimeter in simulated minimum bias events and on the study of how the cell hit distributions change as a function of some particle parameters. The results will contribute to understanding how to optimize the information stored in the shower library under development.

Evaluation of the central libraries information security management at governmental universities located in Tehran, according to the international standard ISO/IEC 27002

Directory of Open Access Journals (Sweden)

Milad Malekolkalami

2014-02-01

Full Text Available This study assessed the evaluation of information security management status in central Libraries of governmental universities located in Tehran, according to ISO / I.E.C. 27002. Research method applied for the study is descriptive Survey and a questionnaire was used for collecting information. The questionnaire was distributed between the 74 central library managers of governmental universities in Tehran according to the recent list on the website of Ministry of Science, Research and Technology, that includes 39 components based on 11 indicators of the standard ISO/ I.E.C. 27002. Analysis of data has been done by using both descriptive and inferential statistics by Microsoft Excel 2007and SPSS statistical softwares. The results of research showed that the mean for libraries in 11 indexes are as follows: The mean for the first index, Security policy, is 3.91 , in the second index, organization of information security, is 4.23, in the third index, asset security management, is 4.38, in the fourth index, Human Resources Security management, is 4, in the fifth index, physical and environment Security management, is 4.07, in the sixth index, operations management and communications, is 4.15, in the Seventh index, access controls management, is 4.38, in the eighth index, information system acquisition, development and maintenance, is 3.92, in the ninth index, information security incident management, is 3.84, in the tenth index, business continuity management, is 3.46, in the eleventh index, compliance, is 3.69 that match with the standard ISO / IEC. 27002. The results of Research shown that totally mean for standard ISO/I.E.C. 27002 in the field of information security management in the central libraries, is 4 being in a good condition and there is no significant differences between the performance of the Central libraries of the governmental Universities in Tehran, since It is not observed significant difference between them in the field of

Synthesis and systematic evaluation of dark resonance energy transfer (DRET)-based library and its application in cell imaging.

Science.gov (United States)

Su, Dongdong; Teoh, Chai Lean; Kang, Nam-Young; Yu, Xiaotong; Sahu, Srikanta; Chang, Young-Tae

2015-03-01

In this paper, we report a new strategy for constructing a dye library with large Stokes shifts. By coupling a dark donor with BODIPY acceptors of tunable high quantum yield, a novel dark resonance energy transfer (DRET)-based library, named BNM, has been synthesized. Upon excitation of the dark donor (BDN) at 490 nm, the absorbed energy is transferred to the acceptor (BDM) with high efficiency, which was tunable in a broad range from 557 nm to 716 nm, with a high quantum yield of up to 0.8. It is noteworthy to mention that the majority of the non-radiative energy loss of the donor was converted into the acceptor's fluorescence output with a minimum leak of donor emission. Fluorescence imaging tested in live cells showed that the BNM compounds are cell-permeable and can also be employed for live-cell imaging. This is a new library which can be excited through a dark donor allowing for strong fluorescence emission in a wide range of wavelengths. Thus, the BNM library is well suited for high-throughput screening or multiplex experiments in biological applications by using a single laser excitation source. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Opening up Library Automation Software

Science.gov (United States)

Breeding, Marshall

2009-01-01

Throughout the history of library automation, the author has seen a steady advancement toward more open systems. In the early days of library automation, when proprietary systems dominated, the need for standards was paramount since other means of inter-operability and data exchange weren't possible. Today's focus on Application Programming…

Data-flow oriented visual programming libraries for scientific computing

NARCIS (Netherlands)

Maubach, J.M.L.; Drenth, W.D.; Sloot, P.M.A.

2002-01-01

The growing release of scientific computational software does not seem to aid the implementation of complex numerical algorithms. Released libraries lack a common standard interface with regard to for instance finite element, difference or volume discretizations. And, libraries written in standard

Evaluating Library Staff: A Performance Appraisal System.

Science.gov (United States)

Belcastro, Patricia

This manual provides librarians and library managers with a performance appraisal system that measures staff fairly and objectively and links performance to the goals of the library. The following topics are addressed: (1) identifying expectations for quality service or standards of performance; (2) the importance of a library's code of service,…

Generation of the WIMS code library from the ENDF/B-VI basic library

International Nuclear Information System (INIS)

Aboustta, Mohamed Ali Bashir.

1994-01-01

The WIMS code is being presently used in many research centers and educational institutions in the world. It has proven to be versatile, reliable and diverse as it is used to calculate different reactor systems. Its data library is rich of useful information that can even be condensed to serve other codes, but the copy distributed with the code is not updated. Some of its data has never been changed, others had changed many times to accommodate certain experimental setups and some data is, simply, not included. This work is an attempt to dominate the techniques used in generating a multigroup library as being applied to the WIMS data library. This new library is called UFMGLIB. A new set of consistent data was generated from the basic ENDF/B-VI library, including complete data for the fission product nuclides and more elaborated burnup chains. The performance of the library is comparable to that of the Standard library accompanying the code and a later library, WIMKAL 88, generated by a group of the Korean Research Institute of Atomic Energy. (author). 38 refs., 40 figs., 30 tabs

Business planning for digital libraries international approaches

CERN Document Server

Collier, Mel

2010-01-01

This book brings together international experience of business planning for digital libraries: the business case, the planning processes involved, the costs and benefi ts, practice and standards, and comparison with the traditional library where appropriate. Although there is a vast literature already on other aspects of digital libraries, business planning is a subject that until now has not been systematically integrated in a book.Digital libraries are being created not only by traditional libraries, but by museums, archives, media organizations, and indeed any organization concerned with ma

Primary culture of cat intestinal epithelial cells in vitro and the cDNA library construction.

Science.gov (United States)

Zhao, Gui Hua; Liu, Ye; Cheng, Yun Tang; Zhao, Qing Song; Qiu, Xiao; Xu, Chao; Xiao, Ting; Zhu, Song; Liu, Gong Zhen; Yin, Kun

2018-06-26

Felids are the only definitive hosts of Toxoplasma gondii. To lay a foundation for screening the T. gondii-felids interaction factors, we have developed a reproducible primary culture method for cat intestinal epithelial cells (IECs). The primary IECs were isolated from a new born cat's small intestine jejunum region without food ingress, and respectively in vitro cultured by tissue cultivation and combined digestion method with collagenase XI and dispase I, then purified by trypsinization. After identification, the ds cDNA of cat IECs was synthesized for constructing pGADT7 homogenization three-frame plasmid, and transformed into the yeast Y187 for generating the cDNA library. Our results indicated that cultivation of primary cat IECs relays on combined digestion to form polarized and confluent monolayers within 3 days with typical features of normal epithelial cells. The purified cells cultured by digestion method were identified to be nature intestinal epithelial cells using immunohistochemical analysis and were able to maintain viability for at least 15 passages. The homogenizable ds cDNA, which is synthesized from the total RNA extracted from our cultured IECs, distributed among 0.5-2.0 kb, and generated satisfying three-frame cDNA library with the capacity of 1.2 × 106 and the titer of 5.2 × 107 pfu/mL. Our results established an optimal method for the culturing and passage of cat IECs model in vitro, and laid a cDNA library foundation for the subsequent interaction factors screening by yeast two-hybrid.

Slovenian Public Libraries in 2010

Directory of Open Access Journals (Sweden)

Gorazd Vodeb

2013-09-01

Full Text Available ABSTRACTPurpose:  The article presents the 2010 Slovenian public library statistics. Performance indicators are compared to library regulations and standards, and to the goals of the Resolution on the 2008-2011 National Programme for Culture. Opening time, library space and equipment, the size of collections and the number of additions are surveyed. Staff structure and financial data are presented as well as the data about visitors, registered members, loans and other library services.   Methodology/approach:  Data collected via the annual statistical survey of Slovenian public libraries are used. They were collected and published by the Library System Development Centre at the National & University Library.   Results:  Data show the stability of the public library income. The level of resources has been generally increased. The number of loans and visits are still rising whereas the number of registered users is slightly dropping. The extent of digitalisation of library materials has been significantly increased.       Research limitation:  The average value of performance indicators is presented.      Originality/practical implications:  Results can be used for monitoring public library development.

Practical application of standards in special libraries

OpenAIRE

Nada Češnovar

1998-01-01

Special libraries in Slovenia represent an important part of information infrastructure.They operate in the spheres of economy, culture, politics, health, and others.Although they perform an important role in the process of professional training of the employees they are too often set aside.Our government is undoubtedly aware of the deficiency of normative regulation in these areas; however, passing of certain acts is often delayed because there is no direct damage to the state itself if they...

Helping Students Use Virtual Libraries Effectively.

Science.gov (United States)

Fitzgerald, Mary Ann; Galloway, Chad

2001-01-01

Describes a study in which online behavior of high school and undergraduate students using GALILEO (Georgia Library Learning Online), a virtual library, were observed. Topics include cognitive demands; technology literacy; domain knowledge; search strategies; relevance; evaluation of information; information literacy standards; and suggestions to…

Construction and identification of subtracted cDNA library in bone marrow cells of radon-exposed mice

International Nuclear Information System (INIS)

Li Jianxiang; Nie Jihua; Tong Jian; Fu Chunling; Zhou Jianwei

2008-01-01

Objective: To construct and identify subtracted cDNA library in bone marrow cells of mice exposed to radon inhalation. Methods: Adult male BALB/c mice, weighing 18-22 g, were placed in a multi- functional radon chamber. One group of mice was exposed to radon up to the accumulative dose of 105 work level month (WLM). The control group of mice was housed in a room with an accumulative dose of 1 WLM. To construct a subtracted cDNA library enriched with differentially expressed genes, the SMART technique and the suppression subtractive hybridization were performed. The obtained forward and reverse cDNA fragments were directly inserted into pMD18-T vector and transformed into E. coli JM109. The inserting cDNA fragments were screened by the blue-and-white blot screening and nested PCR of bacterium liquid. Results: The 244 of 285 white bacteria clones obtained randomly were positive clones contained 100-1100 bp inserted cDNA fragments. Conclusions: The forward and reverse subtracted cDNA library in bone marrow cells of mice exposed to radon inhalation is successfully constructed. (authors)

Construction of a Bacterial Artificial Chromosome Library of TM-1, a Standard Line for Genetics and Genomics in Upland Cotton

Institute of Scientific and Technical Information of China (English)

Yan Hu; Wang-Zhen Guo; Tian-Zhen Zhang

2009-01-01

A bacterial artificial chromosome (BAC) library was constructed for Gossyplum hirsutum acc. TM-1, a genetic and genomic standard line for Upland cotton. The library consists of 147 456 clones with an average insert size of 122.8 kb ranging from 97 to 240 kb. About 96.0% of the clones have inserts over 100 kb. Therefore, this library represents theoretically 7.4 haploid genome equivalents based on an AD genome size of 2 425 Mb. Clones were stored in 384 384- well plates and arrayed into multiplex pools for rapid and reliable library screening. BAC screening was carded out by four-round polymerase chain reactions using 23 simple sequence repeats (SSR) markers, three sequence-related amplified polymorphism markers and one pair of pdmere for a gene associated with fiber development to test the quality of the library. Correspondingly, in total 92 positive BAC clones were Identified with an average four positive clones per SSR marker, ranging from one to eight hits. Additionally, since these SSR markers have been localized to chromosome 12 (A12) and 26 (D12) according to the genetic map, these BAC clonee are expected to serve as seeds for the physical mapping of these two homologous chromosomes, sequentially map-based cloning of quantitative trait loci or genes associated with Important agronomic traits.

Estándares para el Sistema de Bibliotecas de la Universidad de Buenos Aires Standards for the Universidad de Buenos Aires Libraries System

Directory of Open Access Journals (Sweden)

Elsa Elena Elizalde

2009-06-01

Full Text Available La Coordinación General del Sistema de Bibliotecas y de Información -SISBI- de la Universidad de Buenos Aires propuso la conformación de un Grupo de Trabajo para el estudio y la definición de los requerimientos para un adecuado nivel de prestación de los servicios de todas sus bibliotecas. Estos estándares externos completarán y actualizarán los «Lineamientos para una Política Bibliotecaria de la Universidad de Buenos Aires (Resolución CS Nº 222/94». El objetivo del conjunto de criterios que representan estos Estándares para el Sistema de Bibliotecas de la UBA, es que éstas cuenten con una herramienta base que les permita tomar decisiones concernientes a la planificación y administración de los servicios bibliotecarios. Independientemente, se espera que cada Biblioteca defina sus estándares internos de tiempo, calidad, cantidad y costos que reflejen las metas y objetivos de cada Unidad Académica en particular. Estos estándares contemplan: Aspectos organizativos de la Biblioteca Universitaria y Principios Generales del SISBI; Infraestructura Edilicia y Tecnológica; Recursos Humanos; Servicios y/o Productos; Desarrollo de la colección; Procesos Técnicos; Presupuesto; Evaluación y Gestión de la Calidad e Innovación; Prevención y Conservación; entre otros.The General Coordination of the Sistema de Bibliotecas y de Información- SISBI- of the Universidad de Buenos Aires proposed the creation of a Work Group for the study and definition of the requirements for a proper provision level of all libraries services. Those external standards will complement and update the «Guidelines for a Library Policy of the Universidad de Buenos Aires (Resolution N° 222/94». The aim of the whole criteria that represent the Standards for the UBA Libraries System is that they have a basic tool that allow them to take decisions on planning and administration of library services. Separately, it is expected that each Library defines its

Construction of cDNA library and preliminary analysis of expressed sequence tags from Siberian tiger

Science.gov (United States)

Liu, Chang-Qing; Lu, Tao-Feng; Feng, Bao-Gang; Liu, Dan; Guan, Wei-Jun; Ma, Yue-Hui

2010-01-01

In this study we successfully constructed a full-length cDNA library from Siberian tiger, Panthera tigris altaica, the most well-known wild Animal. Total RNA was extracted from cultured Siberian tiger fibroblasts in vitro. The titers of primary and amplified libraries were 1.30×106 pfu/ml and 1.62×109 pfu/ml respectively. The proportion of recombinants from unamplified library was 90.5% and average length of exogenous inserts was 1.13 kb. A total of 282 individual ESTs with sizes ranging from 328 to 1,142bps were then analyzed the BLASTX score revealed that 53.9% of the sequences were classified as strong match, 38.6% as nominal and 7.4% as weak match. 28.0% of them were found to be related to enzyme/catalytic protein, 20.9% ESTs to metabolism, 13.1% ESTs to transport, 12.1% ESTs to signal transducer/cell communication, 9.9% ESTs to structure protein, 3.9% ESTs to immunity protein/defense metabolism, 3.2% ESTs to cell cycle, and 8.9 ESTs classified as novel genes. These results demonstrated that the reliability and representativeness of the cDNA library attained to the requirements of a standard cDNA library. This library provided a useful platform for the functional genomic research of Siberian tigers. PMID:20941376

Library Education: Struggling to Meet the Needs of the Profession.

Science.gov (United States)

Bohannan, April

1991-01-01

Discussion of complaints about library education covers historical perspectives as well as current trends. Topics discussed include library school closings; curriculum; skills and knowledge employers want recent graduates to have; American Library Association (ALA) standards; student perspectives; university views of library schools and faculty;…

[Primary culture of cat intestinal epithelial cell and construction of its cDNA library].

Science.gov (United States)

Ye, L; Gui-Hua, Z; Kun, Y; Hong-Fa, W; Ting, X; Gong-Zhen, L; Wei-Xia, Z; Yong, C

2017-04-12

Objective To establish the primary cat intestinal epithelial cells (IECs) culture methods and construct the cDNA library for the following yeast two-hybrid experiment, so as to screen the virulence interaction factors among the final host. Methods The primary cat IECs were cultured by the tissue cultivation and combined digestion with collagenase XI and dispase I separately. Then the cat IECs cultured was identified with the morphological observation and cyto-keratin detection, by using goat anti-cyto-keratin monoclonal antibodies. The mRNA of cat IECs was isolated and used as the template to synthesize the first strand cDNA by SMART™ technology, and then the double-strand cDNAs were acquired by LD-PCR, which were subsequently cloned into the plasmid PGADT7-Rec to construct yeast two-hybrid cDNA library in the yeast strain Y187 by homologous recombination. Matchmaker™ Insert Check PCR was used to detect the size distribution of cDNA fragments after the capacity calculation of the cDNA library. Results The comparison of the two cultivation methods indicated that the combined digestion of collagenase XI and dispase I was more effective than the tissue cultivation. The cat IECs system of continuous culture was established and the cat IECs with high purity were harvested for constructing the yeast two-hybrid cDNA library. The library contained 1.1×10 6 independent clones. The titer was 2.8×10 9 cfu/ml. The size of inserted fragments was among 0.5-2.0 kb. Conclusion The yeast two-hybrid cDNA library of cat IECs meets the requirements of further screen research, and this study lays the foundation of screening the Toxoplasma gondii virulence interaction factors among the cDNA libraries of its final hosts.

Academic Digital Library Construction Evaluation: Measures and Approaches

OpenAIRE

Wang , Qiyun

2008-01-01

Through review norms, standards and practice related to academic digital library construction evaluation at home and abroad, on the basis of investigation and study on the digital library evaluation at home and abroad, for status quo of the academic digital library construction, using qualitative analysis and quantitative analysis method, with methods and indicators for the traditional library evaluation system as a reference coordinates, put forward a comprehensive evaluation index system of...

Reliability evaluation of high-performance, low-power FinFET standard cells based on mixed RBB/FBB technique

Science.gov (United States)

Wang, Tian; Cui, Xiaoxin; Ni, Yewen; Liao, Kai; Liao, Nan; Yu, Dunshan; Cui, Xiaole

2017-04-01

With shrinking transistor feature size, the fin-type field-effect transistor (FinFET) has become the most promising option in low-power circuit design due to its superior capability to suppress leakage. To support the VLSI digital system flow based on logic synthesis, we have designed an optimized high-performance low-power FinFET standard cell library based on employing the mixed FBB/RBB technique in the existing stacked structure of each cell. This paper presents the reliability evaluation of the optimized cells under process and operating environment variations based on Monte Carlo analysis. The variations are modelled with Gaussian distribution of the device parameters and 10000 sweeps are conducted in the simulation to obtain the statistical properties of the worst-case delay and input-dependent leakage for each cell. For comparison, a set of non-optimal cells that adopt the same topology without employing the mixed biasing technique is also generated. Experimental results show that the optimized cells achieve standard deviation reduction of 39.1% and 30.7% at most in worst-case delay and input-dependent leakage respectively while the normalized deviation shrinking in worst-case delay and input-dependent leakage can be up to 98.37% and 24.13%, respectively, which demonstrates that our optimized cells are less sensitive to variability and exhibit more reliability. Project supported by the National Natural Science Foundation of China (No. 61306040), the State Key Development Program for Basic Research of China (No. 2015CB057201), the Beijing Natural Science Foundation (No. 4152020), and Natural Science Foundation of Guangdong Province, China (No. 2015A030313147).

Beyond Helper Phage: Using "Helper Cells" to Select Peptide Affinity Ligands.

Directory of Open Access Journals (Sweden)

M Lisa Phipps

Full Text Available Peptides are important affinity ligands for microscopy, biosensing, and targeted delivery. However, because they can have low affinity for their targets, their selection from large naïve libraries can be challenging. When selecting peptidic ligands from display libraries, it is important to: 1 ensure efficient display; 2 maximize the ability to select high affinity ligands; and 3 minimize the effect of the display context on binding. The "helper cell" packaging system has been described as a tool to produce filamentous phage particles based on phagemid constructs with varying display levels, while remaining free of helper phage contamination. Here we report on the first use of this system for peptide display, including the systematic characterization and optimization of helper cells, their inefficient use in antibody display and their use in creating and selecting from a set of phage display peptide libraries. Our libraries were analyzed with unprecedented precision by standard or deep sequencing, and shown to be superior in quality than commercial gold standards. Using our helper cell libraries, we have obtained ligands recognizing Yersinia pestis surface antigen F1V and L-glutamine-binding periplasmic protein QBP. In the latter case, unlike any of the peptide library selections described so far, we used a combination of phage and yeast display to select intriguing peptide ligands. Based on the success of our selections we believe that peptide libraries obtained with helper cells are not only suitable, but preferable to traditional phage display libraries for selection of peptidic ligands.

Satisfaction Formation Processes in Library Users: Understanding Multisource Effects

Science.gov (United States)

Shi, Xi; Holahan, Patricia J.; Jurkat, M. Peter

2004-01-01

This study explores whether disconfirmation theory can explain satisfaction formation processes in library users. Both library users' needs and expectations are investigated as disconfirmation standards. Overall library user satisfaction is predicted to be a function of two independent sources--satisfaction with the information product received…

Functional cloning using pFB retroviral cDNA expression libraries.

Science.gov (United States)

Felts, Katherine A; Chen, Keith; Zaharee, Kim; Sundar, Latha; Limjoco, Jamie; Miller, Anna; Vaillancourt, Peter

2002-09-01

Retroviral cDNA expression libraries allow the efficient introduction of complex cDNA libraries into virtually any mitotic cell type for screening based on gene function. The cDNA copy number per cell can be easily controlled by adjusting the multiplicity of infection, thus cell populations may be generated in which >90% of infected cells contain one to three cDNAs. We describe the isolation of two known oncogenes and one cell-surface receptor from a human Burkitt's lymphoma (Daudi) cDNA library inserted into the high-titer retroviral vector pFB.

Determining Gate Count Reliability in a Library Setting

OpenAIRE

Jeffrey Phillips

2016-01-01

Objective – Patron counts are a common form of measurement for library assessment. To develop accurate library statistics, it is necessary to determine any differences between various counting devices. A yearlong comparison between card reader turnstiles and laser gate counters in a university library sought to offer a standard percentage of variance and provide suggestions to increase the precision of counts. Methods – The collection of library exit counts identified the differences be...

Testing of a JEF-1 based WIMS-D cross section library for migration area and k-infinity predictions for LWHCR lattices

International Nuclear Information System (INIS)

Pelloni, S.; Stepanek, J.

1987-01-01

The cell code WIMSD4 is used for the analysis of PROTEUS-LWHCR experiments. A library for this code which is based on the European evaluation JEF-1 was produced at EIR using the Los Alamos NJOY system with its module WIMSR and the Canadian management code WILMA. In general, this library delivered more accurate eigenvalues and reaction rates than the WIMS-Standard and WIMS81 libraries did in comparison to experimental values from PROTEUS-LWHCR Cores 1-3. However, large discrepancies (up to about 10%) occured between calculated migration areas (M 2 ). Additional investigations have been undertaken to clarify this problem, since theoretical M 2 -values are needed for deducing k-infinity in the experiments. This has been done in the context of calculations for a reference LWHCR test lattice. The following major reasons for these deviations were found. First, the self-scattering term in non-moderators (P 0 matrix) in the JEF-1 library was not transport corrected. Second, Standard and JEF-1 libraries use infinite dilute cross sections for 238 U, whereas the WIMS81 library uses fully shielded cross sections. Third, the standard library uses the 'row' formula for the transport correction, whereas the 'inflow' formula is applied in the case of JEF-1 and WIMS81 libraries. Lastly, oxygen and 238 U scattering cross sections in the fast energy range are smaller in the case of the WIMS81 library. Differences in calculated k-infinity values between the currently used library and WIMS81 (up to 3%) come (in order of importance for the reference LWHCR lattice) mainly from resonance cross sections for 240 Pu capture, 238 U capture and 239 Pu fission. Recommendations have been made for generating a new JEF-1 library using updated versions of WIMSR and WILMA. (author)

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries.

Science.gov (United States)

Franzini, Raphael M; Neri, Dario; Scheuermann, Jörg

2014-04-15

proteins and is likely to become a standard tool for pharmaceutical hit discovery, lead expansion, and Chemical Biology research. The introduction of new methodologies for library encoding and for compound synthesis in the presence of DNA is an exciting research field and will crucially contribute to the performance and the propagation of the technology.

Six-Year Planning Report for Crosby Library, Gonzaga University.

Science.gov (United States)

Gonzaga Univ., Spokane, WA.

A response to a call for six-year planning documents from Gonzaga University's instructional units, this report is divided into five broad sections: (1) library collections, an assessment of Crosby Library's holdings and comparison with the overall quantitative standards established by the Association of College and Research Libraries; (2) library…

Effects of the EVCAM chemical validation library on differentiation using marker gene expression in lmouse embryonic stem cells

Science.gov (United States)

The adherent cell differentiation and cytotoxicity (ACDC) assay was used to profile the effects of the ECVAM EST validation chemical library (19 compounds) on J1 mouse embryonic stem cells (mESC). PCR-based TaqMan Low Density Arrays (TLDA) provided a high-content assessment of al...

How libraries use publisher metadata

Directory of Open Access Journals (Sweden)

Steve Shadle

2013-11-01

Full Text Available With the proliferation of electronic publishing, libraries are increasingly relying on publisher-supplied metadata to meet user needs for discovery in library systems. However, many publisher/content provider staff creating metadata are unaware of the end-user environment and how libraries use their metadata. This article provides an overview of the three primary discovery systems that are used by academic libraries, with examples illustrating how publisher-supplied metadata directly feeds into these systems and is used to support end-user discovery and access. Commonly seen metadata problems are discussed, with recommendations suggested. Based on a series of presentations given in Autumn 2012 to the staff of a large publisher, this article uses the University of Washington Libraries systems and services as illustrative examples. Judging by the feedback received from these presentations, publishers (specifically staff not familiar with the big picture of metadata standards work would benefit from a better understanding of the systems and services libraries provide using the data that is created and managed by publishers.

Beamline standard component designs for the Advanced Photon Source

International Nuclear Information System (INIS)

Shu, D.; Barraza, J.; Brite, C.; Chang, J.; Sanchez, T.; Tcheskidov, V.; Kuzay, T.M.

1994-01-01

The Advanced Photon Source (APS) has initiated a design standardization and modularization activity for the APS synchrotron radiation beamline components. These standard components are included in components library, sub-components library and experimental station library. This paper briefly describes these standard components using both technical specifications and side view drawings

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.

Science.gov (United States)

Yofe, Ido; Weill, Uri; Meurer, Matthias; Chuartzman, Silvia; Zalckvar, Einat; Goldman, Omer; Ben-Dor, Shifra; Schütze, Conny; Wiedemann, Nils; Knop, Michael; Khmelinskii, Anton; Schuldiner, Maya

2016-04-01

The yeast Saccharomyces cerevisiae is ideal for systematic studies relying on collections of modified strains (libraries). Despite the significance of yeast libraries and the immense variety of available tags and regulatory elements, only a few such libraries exist, as their construction is extremely expensive and laborious. To overcome these limitations, we developed a SWAp-Tag (SWAT) method that enables one parental library to be modified easily and efficiently to give rise to an endless variety of libraries of choice. To showcase the versatility of the SWAT approach, we constructed and investigated a library of ∼1,800 strains carrying SWAT-GFP modules at the amino termini of endomembrane proteins and then used it to create two new libraries (mCherry and seamless GFP). Our work demonstrates how the SWAT method allows fast and effortless creation of yeast libraries, opening the door to new ways of systematically studying cell biology.

Contents Development of Library Signage Manual in Korea

Directory of Open Access Journals (Sweden)

In-Ja Ahn

2011-12-01

Full Text Available There is an increase in the need of an unified manual for library signage system, due to recent increase in library construction or remodeling. This paper, therefore, can be a basic research to develop library signage system manual. Based on an anual released from KLA and the sum of opinions of expert groups, this research proposes a concrete list of contents for library signage system manual as follows. First, there is a need of theoretical basis of library signage system. Second, for the actual practices of signage system, planning, check list, and standard terms shall be necessary.

Exposing Library Services with AngularJS

OpenAIRE

Jakob Voß; Moritz Horn

2014-01-01

This article provides an introduction to the JavaScript framework AngularJS and specific AngularJS modules for accessing library services. It shows how information such as search suggestions, additional links, and availability can be embedded in any website. The ease of reuse may encourage more libraries to expose their services via standard APIs to allow usage in different contexts.

Human recombinant Fab fragment from combinatorial libraries of a B-cell lymphoma patient recognizes core protein of chondroitin sulphate proteoglycan 4.

Science.gov (United States)

Egami, Yoko; Narushima, Yuta; Ohshima, Motohiro; Yoshida, Akira; Yoneta, Naruki; Masaki, Yasufumi; Itoh, Kunihiko

2018-01-01

CD antigens are well known as therapeutic targets of B-cell lymphoma. To isolate therapeutic antibodies that recognize novel targets other than CD antigens, we constructed a phage display combinatorial antibody Fab library from bone marrow lymphocytes of B-cell lymphoma patient. To eliminate antibodies reactive with known B-cell lymphoma antigen, non-hematopoietic and patient's sera reactive HeLaS3 cells was selected as a target of whole cell panning. Five rounds of panning against live HeLaS3 cells retrieved single Fab clone, termed AHSA (Antibody to HeLa Surface Antigen). Using phage display random peptide library, LSYLEP was identified as an epitope sequence of AHSA. LC-MS/MS analysis of AHSA-precipitated HeLaS3 cell lysates detected several fragments corresponding to the sequence of chondroitin sulphate proteoglycan 4 (CSPG4) core protein. Since LSYLEP sequence was at the position of 313-318 of CSPG4, we considered that CSPG4 was AHSA-associated antigen. Double staining of CSPG4-postive MDA-MB-435S cells with AHSA and anti-CSPG4 rabbit antibody showed identical staining position, and reduced AHSA reactivity was observed in CSPG4-siRNA treated MDA-MB-435S cells. In conclusion, we retrieved a human Fab from antibody library of B-cell lymphoma patient, and identified CSPG4 as a recognizing antigen. AHSA may have potential benefits for development of CSPG4-targeting theranostics for B-cell lymphoma. © The Authors 2017. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

A game-based platform for crowd-sourcing biomedical image diagnosis and standardized remote training and education of diagnosticians

Science.gov (United States)

Feng, Steve; Woo, Minjae; Chandramouli, Krithika; Ozcan, Aydogan

2015-03-01

Over the past decade, crowd-sourcing complex image analysis tasks to a human crowd has emerged as an alternative to energy-inefficient and difficult-to-implement computational approaches. Following this trend, we have developed a mathematical framework for statistically combining human crowd-sourcing of biomedical image analysis and diagnosis through games. Using a web-based smart game (BioGames), we demonstrated this platform's effectiveness for telediagnosis of malaria from microscopic images of individual red blood cells (RBCs). After public release in early 2012 (http://biogames.ee.ucla.edu), more than 3000 gamers (experts and non-experts) used this BioGames platform to diagnose over 2800 distinct RBC images, marking them as positive (infected) or negative (non-infected). Furthermore, we asked expert diagnosticians to tag the same set of cells with labels of positive, negative, or questionable (insufficient information for a reliable diagnosis) and statistically combined their decisions to generate a gold standard malaria image library. Our framework utilized minimally trained gamers' diagnoses to generate a set of statistical labels with an accuracy that is within 98% of our gold standard image library, demonstrating the "wisdom of the crowd". Using the same image library, we have recently launched a web-based malaria training and educational game allowing diagnosticians to compare their performance with their peers. After diagnosing a set of ~500 cells per game, diagnosticians can compare their quantified scores against a leaderboard and view their misdiagnosed cells. Using this platform, we aim to expand our gold standard library with new RBC images and provide a quantified digital tool for measuring and improving diagnostician training globally.

Digital Dilemma: Intellectual Property [and] The ERCIM Technical Reference Digital Library [and] International Information Gateway Collaboration [and] The Standards Fora for Online Education.

Science.gov (United States)

Gladney, Henry M.; Andreoni, Antonella; Baldacci, Maria Bruna; Biagioni, Stefania; Carlesi, Carlo; Castelli, Donatella; Pagano, Pasquale; Peters, Carol; Pisani, Serena; Dempsey, Lorcan; Gardner, Tracy; Day, Michael; van der Werf, Titia; Bacsich, Paul; Heath, Andy; Lefrere, Paul; Miller, Paul; Riley, Kevin

1999-01-01

Includes four articles that discuss the impact of the emerging digital information infrastructure on intellectual property; the implementation of a digital library for a European consortium of national research institutions; an international information gateway collaboration; and developing standards for the description and sharing of educational…

Shared Geospatial Metadata Repository for Ontario University Libraries: Collaborative Approaches

Science.gov (United States)

Forward, Erin; Leahey, Amber; Trimble, Leanne

2015-01-01

Successfully providing access to special collections of digital geospatial data in academic libraries relies upon complete and accurate metadata. Creating and maintaining metadata using specialized standards is a formidable challenge for libraries. The Ontario Council of University Libraries' Scholars GeoPortal project, which created a shared…

Isolation of scFv antibody fragments against HER2 and CEA tumor antigens from combinatorial antibody libraries derived from cancer patients.

Science.gov (United States)

Ayat, Hoda; Burrone, Oscar R; Sadghizadeh, Majid; Jahanzad, Eissa; Rastgou, Nasrin; Moghadasi, Sarrira; Arbabi, Mehdi

2013-11-01

Tumor cells expressing HER-2/neu and CEA antigens are potentially ideal targets for antibody-targeted therapy. In this study, two large human combinatorial libraries have been generated from the lymph nodes of breast cancer patients that express HER2 and CEA antigens in their tumors. These 'immune' libraries have been constructed in two different formats of scFv, differing in the length of the peptide linker connecting the two variable VH and VL domains. Libraries derived from these patients may contain a larger pool of anti-tumor antigen antibodies and are useful repertoire for isolating scFvs against any tumor markers. The results of this study showed that we were successful in obtaining human scFvs against HER-2/neu and CEA. For HER-2, cell-panning strategy was performed and resulted in two scFv binders that detected the complete HER-2 receptor on the cell membrane and internalized to the cells. Also, preliminary ELISA data showed that several anti-CEA scFv binders were isolated by panning. Copyright © 2013 The International Alliance for Biological Standardization. All rights reserved.

Up-date of the BCG code library

International Nuclear Information System (INIS)

Caldeira, A.D.; Garcia, R.D.M.

1990-01-01

Procedures for generating an up-date material library for the BCG code were established. A new library was generated by processing ENDF/B-IV data with the 89-1 version of the LINEAR, RECENT and SIGMA1 programs. The effect of library change in the neutron spectrum and effective multiplication factor of a fast reactor cell was analized. During the course of this study, an error was detected in the BCG code. Although localized in a narrow energy range, the discrepancies in neutron spectrum caused by the error were large enough to yield a difference of about 1% in the effective multiplication factor of the test cell. (author)

Curriculum-based neurosurgery digital library.

Science.gov (United States)

Langevin, Jean-Philippe; Dang, Thai; Kon, David; Sapo, Monica; Batzdorf, Ulrich; Martin, Neil

2010-11-01

Recent work-hour restrictions and the constantly evolving body of knowledge are challenging the current ways of teaching neurosurgery residents. To develop a curriculum-based digital library of multimedia content to face the challenges in neurosurgery education. We used the residency program curriculum developed by the Congress of Neurological Surgeons to structure the library and Microsoft Sharepoint as the user interface. This project led to the creation of a user-friendly and searchable digital library that could be accessed remotely and throughout the hospital, including the operating rooms. The electronic format allows standardization of the content and transformation of the operating room into a classroom. This in turn facilitates the implementation of a curriculum within the training program and improves teaching efficiency. Future work will focus on evaluating the efficacy of the library as a teaching tool for residents.

School Libraries and Student Learning: A Guide for School Leaders

Science.gov (United States)

Morris, Rebecca J.

2015-01-01

Innovative, well-designed school library programs can be critical resources for helping students meet high standards of college and career readiness. In "School Libraries and Student Learning", Rebecca J. Morris shows how school leaders can make the most of their school libraries to support ambitious student learning. She offers…

Can the ISO-standards on quality management be useful to libraries and how?

DEFF Research Database (Denmark)

Johannsen, Carl Gustav

1994-01-01

The aim of this paper is to discuss whether the ISO 9000 concept of quality assurance is useful in a library context or not. First, the basics of the ISO 9000 series are explained. Then, the nature of the concept is discussed and the critical views raised by quality management experts are reviewed...... concluded that the whole discussion on ISO 9000 seems a little futile because the real critical success factor for libraries aiming at Total Quality does not seem to lie in the choice of a specific quality model or guru but more is a question of commitment project on quality assurance in special libraries...

dcmqi: An Open Source Library for Standardized Communication of Quantitative Image Analysis Results Using DICOM.

Science.gov (United States)

Herz, Christian; Fillion-Robin, Jean-Christophe; Onken, Michael; Riesmeier, Jörg; Lasso, Andras; Pinter, Csaba; Fichtinger, Gabor; Pieper, Steve; Clunie, David; Kikinis, Ron; Fedorov, Andriy

2017-11-01

Quantitative analysis of clinical image data is an active area of research that holds promise for precision medicine, early assessment of treatment response, and objective characterization of the disease. Interoperability, data sharing, and the ability to mine the resulting data are of increasing importance, given the explosive growth in the number of quantitative analysis methods being proposed. The Digital Imaging and Communications in Medicine (DICOM) standard is widely adopted for image and metadata in radiology. dcmqi (DICOM for Quantitative Imaging) is a free, open source library that implements conversion of the data stored in commonly used research formats into the standard DICOM representation. dcmqi source code is distributed under BSD-style license. It is freely available as a precompiled binary package for every major operating system, as a Docker image, and as an extension to 3D Slicer. Installation and usage instructions are provided in the GitHub repository at https://github.com/qiicr/dcmqi Cancer Res; 77(21); e87-90. ©2017 AACR . ©2017 American Association for Cancer Research.

The Energy Science and Technology Database on a local library system: A case study at the Los Alamos National Research Library

Energy Technology Data Exchange (ETDEWEB)

Holtkamp, I.S.

1994-10-01

This paper presents an overview of efforts at Los Alamos National Laboratory to acquire and mount the Energy Science and Technology Database (EDB) as a citation database on the Research Library`s Geac Advance system. The rationale for undertaking this project and expected benefits are explained. Significant issues explored are loading non-USMARC records into a MARC-based library system, the use of EDB records to replace or supplement in-house cataloging of technical reports, the impact of different cataloging standards and database size on searching and retrieval, and how integrating an external database into the library`s online catalog may affect staffing and workflow.

Cross Support Transfer Service (CSTS) Framework Library

Science.gov (United States)

Ray, Timothy

2014-01-01

Within the Consultative Committee for Space Data Systems (CCSDS), there is an effort to standardize data transfer between ground stations and control centers. CCSDS plans to publish a collection of transfer services that will each address the transfer of a particular type of data (e.g., tracking data). These services will be called Cross Support Transfer Services (CSTSs). All of these services will make use of a common foundation that is called the CSTS Framework. This library implements the User side of the CSTS Framework. "User side" means that the library performs the role that is typically expected of the control center. This library was developed in support of the Goddard Data Standards program. This technology could be applicable for control centers, and possibly for use in control center simulators needed to test ground station capabilities. The main advantages of this implementation are its flexibility and simplicity. It provides the framework capabilities, while allowing the library user to provide a wrapper that adapts the library to any particular environment. The main purpose of this implementation was to support the inter-operability testing required by CCSDS. In addition, it is likely that the implementation will be useful within the Goddard mission community (for use in control centers).

ZZ MCNPDATA, Standard Neutron, Photon and Electron Data Libraries for MCNP-4C and MCB1C

International Nuclear Information System (INIS)

2002-01-01

1 - Description: These cross-section libraries are released by the Diagnostics Applications Group, X-5, at Los Alamos National Laboratory for use with the MCNP Monte Carlo code package. This release includes all of the X-5 distributed neutron data libraries, the photon libraries MCPLIB1 and MCPLIB02, the electron libraries EL1 and EL03, an updated XSDIR file, and information files Readme.txt and Readme e ndf60.txt. This release is intended to completely replace previous RSICC releases DLC-105, DLC-181, and DLC-189 as well as the cross sections previously included with CCC-200/MCNP4A, and will be updated as new libraries become available. The README file provides information regarding each data library of this release. Additional documentation for some of the individual libraries and example SPECS files for use with MAKXSF are also provided. The XSDIR file is specific to this release and may not work with previous packages. Currently the neutron data library ENDF60 (based on ENDF/B-VI, up through and including release 2) is the default library for continuous-energy neutron transport. Additionally, the libraries MCPLIB02 and EL03 are the default libraries for photon and electron transport respectively. More information on the data libraries contained in this release is available in Appendix G of the MCNP4C manual. 2 - Description of program or function: ZZ-MCB-DLC200 contains the same cross section tables as the DLC-0200/03 package for the MCNP-4C code, except that the installation procedures are adapted to the MCB1C code system (NEA 1643/01). 3 - Application of the data: DLC-200/MCNPDATA is for use with Version 4C and later of the MCNP transport code. This data library provides a comprehensive set of cross sections for a wide range of radiation transport applications using the Monte Carlo code package CCC-700/MCNP4C. See Appendix G of the MCNP report LA-13709-M for information on the libraries and how to select specific nuclides for use in MCNP. 4 - Source and scope

A Spectrum of Interoperability: The Site for Science Prototype for the NSDL; Re-Inventing the Wheel? Standards, Interoperability and Digital Cultural Content; Preservation Risk Management for Web Resources: Virtual Remote Control in Cornell's Project Prism; Safekeeping: A Cooperative Approach to Building a Digital Preservation Resource; Object Persistence and Availability in Digital Libraries; Illinois Digital Cultural Heritage Community-Collaborative Interactions among Libraries, Museums and Elementary Schools.

Science.gov (United States)

Arms, William Y.; Hillmann, Diane; Lagoze, Carl; Krafft, Dean; Marisa, Richard; Saylor, John; Terizzi, Carol; Van de Sompel, Herbert; Gill, Tony; Miller, Paul; Kenney, Anne R.; McGovern, Nancy Y.; Botticelli, Peter; Entlich, Richard; Payette, Sandra; Berthon, Hilary; Thomas, Susan; Webb, Colin; Nelson, Michael L.; Allen, B. Danette; Bennett, Nuala A.; Sandore, Beth; Pianfetti, Evangeline S.

2002-01-01

Discusses digital libraries, including interoperability, metadata, and international standards; Web resource preservation efforts at Cornell University; digital preservation at the National Library of Australia; object persistence and availability; collaboration among libraries, museums and elementary schools; Asian digital libraries; and a Web…

The Malaria in Pregnancy Library: a bibliometric review

NARCIS (Netherlands)

van Eijk, Anna M.; Hill, Jenny; Povall, Sue; Reynolds, Alison; Wong, Helen; ter Kuile, Feiko O.

2012-01-01

The Malaria in Pregnancy (MiP) Library is a bibliographic database that was created by the MiP Consortium in 2005 and is updated every four months using a standardized search protocol. A bibliometric review was conducted of the contents of the Library to determine dynamics in the type, content and

Profesional medical library education in the United States in relation to the qualifications of medical library manpower in Ohio.

Science.gov (United States)

Rees, A M; Rothenberg, L; Denison, B

1968-10-01

THE PRESENT SYSTEM OF EDUCATION FOR MEDICAL LIBRARY PRACTICE IN THE UNITED STATES CONSISTS OF FOUR MAJOR COMPONENTS: graduate degree programs in library science with specialization in medical librarianship; graduate degree programs in library science with no such specialization; postgraduate internships in medical libraries; continuing education programs. Data are presented illustrating the flow of graduates along these several educational pathways into medical library practice.The relevance of these educational components to the current medical library work force is discussed with reference to manpower data compiled for Ohio. The total number of medical library personnel in Ohio in 1968 is 316. Of this total, only forty-two (approximately 14 percent) have received any formal library training. Seventy persons have only a high school education. From these figures, it is concluded that there is no standard or essential qualification which is universally accepted as educational preparation for work in medical libraries; that the comparative sophistication of the educational programs in medical librarianship has yet to be reflected widely in general medical library practice; that an increasingly large number of non-professional or ancillary personnel are being, and will continue to be, utilized in medical libraries; that large numbers of untrained persons have sole responsibility for medical libraries; and that appropriate educational programs will have to be designed specifically for this type of personnel.

Cross-section library and processing techniques within the SCALE system

International Nuclear Information System (INIS)

Westfall, R.M.

1986-01-01

A summary of each of the SCALE system features involved in problem-dependent cross section processing is presented. These features include criticality libraries, shielding libraries, the Standard Composition Library, the SCALE functional modules: BONAMI-S, NITAWL-S, XSDRNPM-S, ICE-S, and the Material Information Processor. The automated procedure for cross-section processing is described with examples. 15 refs

Is There a Global Role for Metropolitan City Libraries?

Science.gov (United States)

Mason, Marilyn Gell

1994-01-01

Discusses the potential for linking large metropolitan public libraries to international interlibrary loan networks. Issues involved in international networking, including funding, standards, network connectivity, and protectionism, are discussed. Examples of libraries capable of participating and brief descriptions of their collections are given.…

Access to IEEE Electronic Library

CERN Multimedia

2007-01-01

From 2007, the CERN Library now offers readers online access to the complete IEEE Electronic Library (Institute of Electrical and Electronics Engineers). This new licence gives unlimited online access to all IEEE and IET (previously IEE) journals and proceedings as well as all current IEEE standards and selected archived ones. Some of the titles offer volumes back to 1913. This service currently represents more than 1,400,000 full-text articles! This leading engineering information resource replaces the previous service, a sub-product of the IEEE database called 'IEEE Enterprise', which offered online access to the complete collection of IEEE journals and proceedings, but with limited features. The service had become so popular that the CERN Working Group for Acquisitions recommended that the Library subscribe to the complete IEEE Electronic Library for 2007. Usage statistics for recent months showed there was a demand for the service from a large community of CERN users and we were aware that many users h...

Ergonomics: case study in a university library

Directory of Open Access Journals (Sweden)

Daniela Capri

2012-08-01

Full Text Available This final paper aimed to analyze the real ergonomics of a university library from Florianópolis and compare it with the ergonomics perceived by the user to perform an ergonomic diagnosis. In order to meet this goal two specific goals were established such as: describe the physical and environmental aspects of the library related to the real ergonomics and verify the actual perception of users about the library. As a theoretical approach, aspects of ergonomics and environmental ergonomics were contextualized and linked to the library and the university library. Referring to the methodology, the Ergonomical Assessment of the Built Environment was used as a reference. The study subjects comprised a sample of 15, among students and library staff. In the results obtained, when related to the physical-environmental analysis of the library, it was found that there are some aspects that differ from the regulatory standards and that also fall short in relation to feedback from users. Aspects such as lighting and noise were cited as unsatisfactory, but the temperature factor was analyzed as satisfactory.

Identifying a compound modifying a cellular response, comprises attaching cells having a reporter system onto solid supports, releasing a library member, screening and identifying target cells

DEFF Research Database (Denmark)

2011-01-01

The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. Test compounds modulating a cellular response, for example via a cell surface molecule...... may be identified by selecting solid supports comprising cells, wherein the cellular response of interest has been modulated. The cellular response may for example be changes in signal transduction pathways modulated by a cell surface molecule....

Library legislation and free access to information as new topics in library and information science education.

Directory of Open Access Journals (Sweden)

2000-01-01

Full Text Available An outline of LIS programs offered by the Department of Information Sciences, Faculty of Philosophy, University of Zagreb is given. Factors affecting the recent curriculum revision are described and the reasons for the introduction of a new course in library legislation and standards have been pointed out. The intention of the course has been to make students aware of the existence of international documents relevant to libraries and librarians and to show how the current trends are reflected in national legislation. It is hoped that the course might help students improve their understanding of the legal context surrounding libraries and other information institutions and teach them to appreciate the importance of good legislation.

Use of Audiobooks in a School Library and Positive Effects of Struggling Readers' Participation in a Library-Sponsored Audiobook Club

Science.gov (United States)

Whittingham, Jeff; Huffman, Stephanie; Christensen, Rob; McAllister, Tracy

2013-01-01

A study was conducted to determine the impact of the use of audiobooks with struggling readers in a school library audiobook club. The participants met weekly in the school library with the school librarian and researchers to discuss audiobooks and make reading recommendations to their peers. Standardized test data as well as pre- and post-study…

Quantifying and resolving multiple vector transformants in S. cerevisiae plasmid libraries.

Science.gov (United States)

Scanlon, Thomas C; Gray, Elizabeth C; Griswold, Karl E

2009-11-20

In addition to providing the molecular machinery for transcription and translation, recombinant microbial expression hosts maintain the critical genotype-phenotype link that is essential for high throughput screening and recovery of proteins encoded by plasmid libraries. It is known that Escherichia coli cells can be simultaneously transformed with multiple unique plasmids and thusly complicate recombinant library screening experiments. As a result of their potential to yield misleading results, bacterial multiple vector transformants have been thoroughly characterized in previous model studies. In contrast to bacterial systems, there is little quantitative information available regarding multiple vector transformants in yeast. Saccharomyces cerevisiae is the most widely used eukaryotic platform for cell surface display, combinatorial protein engineering, and other recombinant library screens. In order to characterize the extent and nature of multiple vector transformants in this important host, plasmid-born gene libraries constructed by yeast homologous recombination were analyzed by DNA sequencing. It was found that up to 90% of clones in yeast homologous recombination libraries may be multiple vector transformants, that on average these clones bear four or more unique mutant genes, and that these multiple vector cells persist as a significant proportion of library populations for greater than 24 hours during liquid outgrowth. Both vector concentration and vector to insert ratio influenced the library proportion of multiple vector transformants, but their population frequency was independent of transformation efficiency. Interestingly, the average number of plasmids born by multiple vector transformants did not vary with their library population proportion. These results highlight the potential for multiple vector transformants to dominate yeast libraries constructed by homologous recombination. The previously unrecognized prevalence and persistence of multiply

Quantifying and resolving multiple vector transformants in S. cerevisiae plasmid libraries

Directory of Open Access Journals (Sweden)

Gray Elizabeth C

2009-11-01

Full Text Available Abstract Background In addition to providing the molecular machinery for transcription and translation, recombinant microbial expression hosts maintain the critical genotype-phenotype link that is essential for high throughput screening and recovery of proteins encoded by plasmid libraries. It is known that Escherichia coli cells can be simultaneously transformed with multiple unique plasmids and thusly complicate recombinant library screening experiments. As a result of their potential to yield misleading results, bacterial multiple vector transformants have been thoroughly characterized in previous model studies. In contrast to bacterial systems, there is little quantitative information available regarding multiple vector transformants in yeast. Saccharomyces cerevisiae is the most widely used eukaryotic platform for cell surface display, combinatorial protein engineering, and other recombinant library screens. In order to characterize the extent and nature of multiple vector transformants in this important host, plasmid-born gene libraries constructed by yeast homologous recombination were analyzed by DNA sequencing. Results It was found that up to 90% of clones in yeast homologous recombination libraries may be multiple vector transformants, that on average these clones bear four or more unique mutant genes, and that these multiple vector cells persist as a significant proportion of library populations for greater than 24 hours during liquid outgrowth. Both vector concentration and vector to insert ratio influenced the library proportion of multiple vector transformants, but their population frequency was independent of transformation efficiency. Interestingly, the average number of plasmids born by multiple vector transformants did not vary with their library population proportion. Conclusion These results highlight the potential for multiple vector transformants to dominate yeast libraries constructed by homologous recombination. The

Ethical and professional standards compliance among practicing ...

African Journals Online (AJOL)

This study investigated ethical and professional standards compliance among practicing librariansin university libraries in Benue State. The purpose of the study was todetermine the extent to which librarians in university libraries comply with ethics and professional standards in librarianship. The study adopted a descriptive ...

Novel search algorithms for a mid-infrared spectral library of cotton contaminants.

Science.gov (United States)

Loudermilk, J Brian; Himmelsbach, David S; Barton, Franklin E; de Haseth, James A

2008-06-01

During harvest, a variety of plant based contaminants are collected along with cotton lint. The USDA previously created a mid-infrared, attenuated total reflection (ATR), Fourier transform infrared (FT-IR) spectral library of cotton contaminants for contaminant identification as the contaminants have negative impacts on yarn quality. This library has shown impressive identification rates for extremely similar cellulose based contaminants in cases where the library was representative of the samples searched. When spectra of contaminant samples from crops grown in different geographic locations, seasons, and conditions and measured with a different spectrometer and accessories were searched, identification rates for standard search algorithms decreased significantly. Six standard algorithms were examined: dot product, correlation, sum of absolute values of differences, sum of the square root of the absolute values of differences, sum of absolute values of differences of derivatives, and sum of squared differences of derivatives. Four categories of contaminants derived from cotton plants were considered: leaf, stem, seed coat, and hull. Experiments revealed that the performance of the standard search algorithms depended upon the category of sample being searched and that different algorithms provided complementary information about sample identity. These results indicated that choosing a single standard algorithm to search the library was not possible. Three voting scheme algorithms based on result frequency, result rank, category frequency, or a combination of these factors for the results returned by the standard algorithms were developed and tested for their capability to overcome the unpredictability of the standard algorithms' performances. The group voting scheme search was based on the number of spectra from each category of samples represented in the library returned in the top ten results of the standard algorithms. This group algorithm was able to identify

Electronic Health Record Meets Digital Library

Science.gov (United States)

Humphreys, Betsy L.

2000-01-01

Linking the electronic health record to the digital library is a Web-era reformulation of the long-standing informatics goal of seamless integration of automated clinical data and relevant knowledge-based information to support informed decisions. The spread of the Internet, the development of the World Wide Web, and converging format standards for electronic health data and digital publications make effective linking increasingly feasible. Some existing systems link electronic health data and knowledge-based information in limited settings or limited ways. Yet many challenging informatics research problems remain to be solved before flexible and seamless linking becomes a reality and before systems become capable of delivering the specific piece of information needed at the time and place a decision must be made. Connecting the electronic health record to the digital library also requires positive resolution of important policy issues, including health data privacy, government envouragement of high-speed communications, electronic intellectual property rights, and standards for health data and for digital libraries. Both the research problems and the policy issues should be important priorities for the field of medical informatics. PMID:10984463

About the Library - Betty Petersen Memorial Library

Science.gov (United States)

branch library of the NOAA Central Library. The library serves the NOAA Science Center in Camp Springs , Maryland. History and Mission: Betty Petersen Memorial Library began as a reading room in the NOAA Science Science Center staff and advises the library on all aspects of the library program. Library Newsletters

Managing ebook metadata in academic libraries taming the tiger

CERN Document Server

Frederick, Donna E

2016-01-01

Managing ebook Metadata in Academic Libraries: Taming the Tiger tackles the topic of ebooks in academic libraries, a trend that has been welcomed by students, faculty, researchers, and library staff. However, at the same time, the reality of acquiring ebooks, making them discoverable, and managing them presents library staff with many new challenges. Traditional methods of cataloging and managing library resources are no longer relevant where the purchasing of ebooks in packages and demand driven acquisitions are the predominant models for acquiring new content. Most academic libraries have a complex metadata environment wherein multiple systems draw upon the same metadata for different purposes. This complexity makes the need for standards-based interoperable metadata more important than ever. In addition to complexity, the nature of the metadata environment itself typically varies slightly from library to library making it difficult to recommend a single set of practices and procedures which would be releva...

Effect of updated WIMSD libraries on neutron energy spectrum at irradiation site of Pakistan Research Reactor-1 using 3D modeling

International Nuclear Information System (INIS)

Ahmad, Siraj-ul-Islam; Ahmad, Nasir

2005-01-01

International Atomic Energy Agency (IAEA) has recently released new WIMSD libraries based on current cross-section evaluations. Using these libraries the effect of different evaluated data sets on effective multiplication factor and neutron energy spectrum was studied with the help of 3D reactor simulation code CITATION. Simulation methodology adopted in this work was validated by analyzing IAEA 10 MW benchmark reactor. The k eff values obtained using all newly released libraries are within 0.45% to the experimental value, while the old library released in 1981 resulted in calculated value 1.05% larger than experimental. The flux spectrum obtained for standard fuel element using 3D modeling is smaller in fast energy range and higher in thermal energy range than is calculated using the 1D model for the standard cell. In the flux trap, differences of about -4% to 13% were found in thermal flux using the newly released libraries as compared to that obtained using 1981 WIMSD library. The major differences in the flux spectra between newly available libraries and the 1981 WIMSD library in thermal energy range are due to the differences in cross-sections of hydrogen bound-in-water. The use of only newly available cross-sections of hydrogen bound-in-water with 1981 WIMSD library resulted in significant improvement in value of k eff as well as in the flux spectrum. Moreover the differences among new libraries in the thermal energy range are also due to these cross-sections. Difference in fission spectra from different libraries is responsible for differences of flux spectra in the fast energy range. These differences in flux are reduced significantly in the fast energy range by only replacement of fission spectra

Persistent Issues in Library and Information Science Education in Africa.

Science.gov (United States)

Alemna, A. A.

1994-01-01

Discusses issues relating to library and information science education in Africa. Topics include a historical background; professional recognition; standards; student recruitment; physical facilities; relevance of the curricula; financial constraints; research degrees; continuing education; paraprofessional library staff training; employment…

America's Star Libraries, 2010: Top-Rated Libraries

Science.gov (United States)

Lyons, Ray; Lance, Keith Curry

2010-01-01

The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

The Renaissance in Library Buildings

Directory of Open Access Journals (Sweden)

Sarah E. Thomas

2004-05-01

Full Text Available In the enthusiastic embrace of the digital library, with its anytime, anywhere characteristics, some people have assumed that physical libraries will become obsolete. Yet an examination of the behavior of students and faculty and of recent renovation and construction of academic and research libraries shows that brick and mortar buildings are enjoying a renaissance. Libraries have traditionally supported the housing of collections, reader services, and the staff who manage collections and provide services. These three components continue in the 21st century, but librarians, architects, and users are collaborating to produce elegant and functional designs that reflect new spatial allocations and new purposes. Modern libraries incorporate flexibility and comfort to create an environment that is welcoming and that supports a range of research and learning activities. This paper draws on examples from recent construction and reconfiguration of academic libraries in the United States to illustrate the changing scope of the physical library and the important role it plays in serving as a community hub within a university. Among the examples selected are several relating to the challenges of collection management, including the use of compact shelving and high-density storage facilities. The paper also traces the evolution of spaces from the catalog card era to the present state in which wireless access is a standard feature. Lastly, the author touches on new and expanded roles for librarians and the ways in which design advances the effectiveness of information professionals in fulfilling these new roles.

EASIER ACCESS TO STANDARDS DOCUMENTATION

CERN Multimedia

2001-01-01

Many organizations issuing standards offer reduced prices for publications to their members. Paying a membership fee, even a site membership fee, can therefore be worthwhile - even if relatively few standards are needed. The Library is now exploring the possibility, in collaboration with the rest of the CERN community, of joining standards-issuing organizations. So why not share your costs with the rest of the organization wherever this can be done without violating copyright or access regulations? The Library now provides documentation and other member services from IPC, the Association Connecting Electronics Industries (http://www.ipc.org/html/fsabout.htm) at favourable prices for the entire CERN population. For more information, or if you are a member of any other organization which provides services which could be shared CERN-wide, please contact library.desk@cern.ch . We remind all users of international standards, that CERN has special agreements with ISO and IEC (see Bulletin 50/2000). You can order st...

Hijazi Architectural Object Library (haol)

Science.gov (United States)

Baik, A.; Boehm, J.

2017-02-01

As with many historical buildings around the world, building façades are of special interest; moreover, the details of such windows, stonework, and ornaments give each historic building its individual character. Each object of these buildings must be classified in an architectural object library. Recently, a number of researches have been focusing on this topic in Europe and Canada. From this standpoint, the Hijazi Architectural Objects Library (HAOL) has reproduced Hijazi elements as 3D computer models, which are modelled using a Revit Family (RFA). The HAOL will be dependent on the image survey and point cloud data. The Hijazi Object such as Roshan and Mashrabiyah, become as vocabulary of many Islamic cities in the Hijazi region such as Jeddah in Saudi Arabia, and even for a number of Islamic historic cities such as Istanbul and Cairo. These architectural vocabularies are the main cause of the beauty of these heritage. However, there is a big gap in both the Islamic architectural library and the Hijazi architectural library to provide these unique elements. Besides, both Islamic and Hijazi architecture contains a huge amount of information which has not yet been digitally classified according to period and styles. Due to this issue, this paper will be focusing on developing of Heritage BIM (HBIM) standards and the HAOL library to reduce the cost and the delivering time for heritage and new projects that involve in Hijazi architectural styles. Through this paper, the fundamentals of Hijazi architecture informatics will be provided via developing framework for HBIM models and standards. This framework will provide schema and critical information, for example, classifying the different shapes, models, and forms of structure, construction, and ornamentation of Hijazi architecture in order to digitalize parametric building identity.

A more complete library on your desktop

CERN Multimedia

2003-01-01

The CERN library announces two new services: a complete database on standards containing the description of 400,000 standards, and a collection of scientific journals with more than three million articles. These include historical papers, some of them dating from the end of the 19th century.

E.O.L Eguavoen A SURVEY OF LIBRARY EQUIPMENTS IN ...

African Journals Online (AJOL)

The data were collated, analyzed and interpreted based on standard statistical method. ... Keywords: Library equipment, academic libraries, Ibadan, Oyo State ... (1992), facilities constitute a strategic factor in organizational functioning. ... through provision of safe structure, adequate sanitary facilities, a balanced visual.

A lanthipeptide library used to identify a protein-protein interaction inhibitor.

Science.gov (United States)

Yang, Xiao; Lennard, Katherine R; He, Chang; Walker, Mark C; Ball, Andrew T; Doigneaux, Cyrielle; Tavassoli, Ali; van der Donk, Wilfred A

2018-04-01

In this article we describe the production and screening of a genetically encoded library of 10 6 lanthipeptides in Escherichia coli using the substrate-tolerant lanthipeptide synthetase ProcM. This plasmid-encoded library was combined with a bacterial reverse two-hybrid system for the interaction of the HIV p6 protein with the UEV domain of the human TSG101 protein, which is a critical protein-protein interaction for HIV budding from infected cells. Using this approach, we identified an inhibitor of this interaction from the lanthipeptide library, whose activity was verified in vitro and in cell-based virus-like particle-budding assays. Given the variety of lanthipeptide backbone scaffolds that may be produced with ProcM, this method may be used for the generation of genetically encoded libraries of natural product-like lanthipeptides containing substantial structural diversity. Such libraries may be combined with any cell-based assay to identify lanthipeptides with new biological activities.

Multigroup cross section library; WIMS library

International Nuclear Information System (INIS)

Kannan, Umasankari

2000-01-01

The WIMS library has been extensively used in thermal reactor calculations. This multigroup constants library was originally developed from the UKNDL in the late 60's and has been updated in 1986. This library has been distributed with the WIMS-D code by NEA data bank. The references to WIMS library in literature are the 'old' which is the original as developed by the AEA Winfrith and the 'new' which is the current 1986 WIMS library. IAEA has organised a CRP where a new and fully updated WIMS library will soon be available. This paper gives an overview of the definitions of the group constants that go into any basic nuclear data library used for reactor calculations. This paper also outlines the contents of the WIMS library and some of its shortcomings

Is There a Standard Default Keyword Operator? A Bibliometric Analysis of Processing Options Chosen by Libraries To Execute Keyword Searches in Online Public Access Catalogs.

Science.gov (United States)

Klein, Gary M.

1994-01-01

Online public access catalogs from 67 libraries using NOTIS software were searched using Internet connections to determine the positional operators selected as the default keyword operator on each catalog. Results indicate the lack of a processing standard for keyword searches. Five tables provide information. (Author/AEF)

Benchmarking Reference Desk Service in Academic Health Science Libraries: A Preliminary Survey.

Science.gov (United States)

Robbins, Kathryn; Daniels, Kathleen

2001-01-01

This preliminary study was designed to benchmark patron perceptions of reference desk services at academic health science libraries, using a standard questionnaire. Responses were compared to determine the library that provided the highest-quality service overall and along five service dimensions. All libraries were rated very favorably, but none…

Using scientific evidence to improve hospital library services: Southern Chapter/Medical Library Association journal usage study.

Science.gov (United States)

Dee, C R; Rankin, J A; Burns, C A

1998-07-01

Journal usage studies, which are useful for budget management and for evaluating collection performance relative to library use, have generally described a single library or subject discipline. The Southern Chapter/Medical Library Association (SC/MLA) study has examined journal usage at the aggregate data level with the long-term goal of developing hospital library benchmarks for journal use. Thirty-six SC/MLA hospital libraries, categorized for the study by size as small, medium, or large, reported current journal title use centrally for a one-year period following standardized data collection procedures. Institutional and aggregate data were analyzed for the average annual frequency of use, average costs per use and non-use, and average percent of non-used titles. Permutation F-type tests were used to measure difference among the three hospital groups. Averages were reported for each data set analysis. Statistical tests indicated no significant differences between the hospital groups, suggesting that benchmarks can be derived applying to all types of hospital libraries. The unanticipated lack of commonality among heavily used titles pointed to a need for uniquely tailored collections. Although the small sample size precluded definitive results, the study's findings constituted a baseline of data that can be compared against future studies.

CBCT-guided evolutive library for cervical adaptive IMRT.

Science.gov (United States)

Rigaud, Bastien; Simon, Antoine; Gobeli, Maxime; Lafond, Caroline; Leseur, Julie; Barateau, Anais; Jaksic, Nicolas; Castelli, Joël; Williaume, Danièle; Haigron, Pascal; De Crevoisier, Renaud

2018-04-01

In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs [with empty (EB), intermediate (IB), and full (FB) bladder volumes], a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed. Five RT strategies were simulated for each patient: "Standard RT" was based on one IB planning CT; "internal target volume (ITV)-based RT" was an ITV built from the three planning CTs; "RT with one mid-treatment replanning (MidTtReplan)" corresponded to the standard RT with a replanning at 20 Gy; "Pretreatment library ART" using a planning library based on the three planning CTs; and the "Evolutive library ART", which was the "Pretreatment library ART" strategy enriched by including some CBCT anatomies into the library when the daily clinical target volume (CTV) shape differed from the ones in the library. Two planning target volume (PTV) margins of 7 and 10 mm were evaluated. All the strategies were geometrically compared in terms of the percentage of coverage by the PTV, for the CTV and the organs at risk (OAR) delineated on the CBCT. Inadequate coverage of the CTV and OARs by the PTV was also assessed using deformable image registration. The cumulated dose distributions of each strategy were likewise estimated and compared for one patient. The "Evolutive library ART" strategy involved a number of added CBCTs: 0 for 55%; 1 for 30%; 2 for 5%; and 3 for 10% of patients. Compared with the other four, this strategy provided the highest CTV geometric coverage by the PTV, with a mean (min-max) coverage of 98.5% (96.4-100) for 10 mm margins and 96.2% (93.0-99.7) for 7 mm margins (P < 0.05). Moreover, this strategy significantly decreased the geometric coverage of the bowel

New data libraries and physics data management tools

International Nuclear Information System (INIS)

Han, M; Kim, C H; Seo, H; Pia, M G; Saracco, P; Augelli, M; Hauf, S; Kuster, M; Moneta, L; Quintieri, L

2011-01-01

A number of physics data libraries for Monte Carlo simulation are reviewed. The development of a package for the management of physics data is described: its design, implementation and computational benchmarks. This package improves the data management tools originally developed for Geant4 electromagnetic physics models based on data libraries. The implementation exploits recent evolutions of the C++ libraries appearing in the C++0x draft, which are intended for inclusion in the next C++ ISO Standard. The new tools improve the computational performance of physics data management.

Library Services Funding Assessment

Science.gov (United States)

Lorig, Jonathan A.

2004-01-01

collect as much of the relevant data as possible. Hopefully this dataset will permit the research units at the GRC, and library administration as well, to make informed decisions about future library funding. Prior to the creation of the actual dataset, I established a comprehensive list of the library s print and online journal subscriptions. This list will be useful outside the context of the cost analysis project, as an addition to the library website. The cost analysis dataset s primary fields are: journal name, vendor, publisher, ISSN (International Standard Serial Number, to uniquely identify the titles), stand-alone price, and indication as to the presence of the journal in current GRC Technical Library consortium membership subscriptions. The dataset will hopefully facilitate comparisons between the stand-alone journal prices and the cost of shared journal subscriptions for groups of titles.

An SSH library responsive to azadirachtin A constructed in Spodoptera litura Fabricius cell lines.

Science.gov (United States)

Yan, Chao; Zhang, Zhi-Xiang; Xu, Han-Hong

2012-05-31

The present study revealed differentially expressed genes responsive to azadirachtin A (Aza) in Spodoptera litura cell line through suppression subtractive hybridization. In the Aza-responsive SSH library, approximately 270 sequences represent 53 different identified genes encoding proteins with various predicted functions, and the percentages of the gene clusters were 26.09% (genetic information processing), 11.41% (cell growth and death), 7.07% (metabolism), 6.52% (signal transduction/transport) and 2.72% (immunity), respectively. Eleven clones homologous to identified genes were selected to be confirmed through quantitative real time polymerase chain reaction. Among the eleven clones validated, all but one transcript of lipase showed an increase in SL cell line collected from ETA, whereas the transcripts of other genes were lower in the SL cell line collected from ETA compared with that of UETA. These genes were considered to be related to the response of SL cell line to Aza. These will provide a new clue to uncover the molecular mechanisms of Aza acting on SL cell line. Copyright © 2012 Elsevier B.V. All rights reserved.

Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity

Directory of Open Access Journals (Sweden)

Alessandra M. Welker

2016-02-01

Full Text Available Glioblastoma (GBM is a deadly brain cancer, for which few effective drug treatments are available. Several studies have used zebrafish models to study GBM, but a standardized approach to modeling GBM in zebrafish was lacking to date, preventing comparison of data across studies. Here, we describe a new, standardized orthotopic xenotransplant model of GBM in zebrafish. Dose-response survival assays were used to define the optimal number of cells for tumor formation. Techniques to measure tumor burden and cell spread within the brain over real time were optimized using mouse neural stem cells as control transplants. Applying this standardized approach, we transplanted two patient-derived GBM cell lines, serum-grown adherent cells and neurospheres, into the midbrain region of embryonic zebrafish and analyzed transplanted larvae over time. Progressive brain tumor growth and premature larval death were observed using both cell lines; however, fewer transplanted neurosphere cells were needed for tumor growth and lethality. Tumors were heterogeneous, containing both cells expressing stem cell markers and cells expressing markers of differentiation. A small proportion of transplanted neurosphere cells expressed glial fibrillary acidic protein (GFAP or vimentin, markers of more differentiated cells, but this number increased significantly during tumor growth, indicating that these cells undergo differentiation in vivo. By contrast, most serum-grown adherent cells expressed GFAP and vimentin at the earliest times examined post-transplant. Both cell types produced brain tumors that contained Sox2+ cells, indicative of tumor stem cells. Transplanted larvae were treated with currently used GBM therapeutics, temozolomide or bortezomib, and this resulted in a reduction in tumor volume in vivo and an increase in survival. The standardized model reported here facilitates robust and reproducible analysis of glioblastoma tumor cells in real time and provides a

CellPilot: Seamless communication within Cell BE and heterogeneous clusters

International Nuclear Information System (INIS)

Girard, N; Carter, J; Gardner, W B; Grewal, G

2010-01-01

The Pilot library is targeted to novice scientific programmers within High Performance Computing. The CellPilot library extends the Pilot library to the Cell Broadband Engine processor and heterogeneous clusters. Using Pilot's process and channel abstractions, the CellPilot library can create a process on any of the processor types, both PPEs and SPEs, across the cluster. Communication is achieved by creating a channel between any two processes, and using the write/read channel functions in the participating processes. The CellPilot library uses MPI for the inter-node communication and the Cell SDK within a Cell node. All the architecture specific details of Cell communications are hidden from the user.

Methods for transforming and expression screening of filamentous fungal cells with a DNA library

Science.gov (United States)

Teter, Sarah; Lamsa, Michael; Cherry, Joel; Ward, Connie

2015-06-02

The present invention relates to methods for expression screening of filamentous fungal transformants, comprising: (a) isolating single colony transformants of a DNA library introduced into E. coli; (b) preparing DNA from each of the single colony E. coli transformants; (c) introducing a sample of each of the DNA preparations of step (b) into separate suspensions of protoplasts of a filamentous fungus to obtain transformants thereof, wherein each transformant contains one or more copies of an individual polynucleotide from the DNA library; (d) growing the individual filamentous fungal transformants of step (c) on selective growth medium, thereby permitting growth of the filamentous fungal transformants, while suppressing growth of untransformed filamentous fungi; and (e) measuring activity or a property of each polypeptide encoded by the individual polynucleotides. The present invention also relates to isolated polynucleotides encoding polypeptides of interest obtained by such methods, to nucleic acid constructs, expression vectors, and recombinant host cells comprising the isolated polynucleotides, and to methods of producing the polypeptides encoded by the isolated polynucleotides.

Library 3.0 intelligent libraries and apomediation

CERN Document Server

Kwanya, Tom; Underwood, Peter

2015-01-01

The emerging generation of research and academic library users expect the delivery of user-centered information services. 'Apomediation' refers to the supporting role librarians can give users by stepping in when users need help. Library 3.0 explores the ongoing debates on the "point oh” phenomenon and its impact on service delivery in libraries. This title analyses Library 3.0 and its potential in creating intelligent libraries capable of meeting contemporary needs, and the growing role of librarians as apomediators. Library 3.0 is divided into four chapters. The first chapter introduces and places the topic in context. The second chapter considers "point oh” libraries. The third chapter covers library 3.0 librarianship, while the final chapter explores ways libraries can move towards '3.0'.

Construction and Screening of a Lentiviral Secretome Library.

Science.gov (United States)

Liu, Tao; Jia, Panpan; Ma, Huailei; Reed, Sean A; Luo, Xiaozhou; Larman, H Benjamin; Schultz, Peter G

2017-06-22

Over 2,000 human proteins are predicted to be secreted, but the biological function of the many of these proteins is still unknown. Moreover, a number of these proteins may act as new therapeutic agents or be targets for the development of therapeutic antibodies. To further explore the extracellular proteome, we have developed a secretome-enriched open reading frame (ORF) library that can be readily screened for autocrine activity in cell-based phenotypic or reporter assays. Next-generation sequencing (NGS) and database analysis predict that the library contains approximately 900 ORFs encoding known secreted proteins (accounting for 77.8% of the library), as well as genes encoding potentially unknown secreted proteins. In a proof-of-principle study, human TF-1 cells were screened for proliferative factors, and the known cytokine GMCSF was identified as a dominant hit. This library offers a relatively low-cost and straightforward approach for functional autocrine screens of secreted proteins. Copyright © 2017 Elsevier Ltd. All rights reserved.

NSUF Irradiated Materials Library

Energy Technology Data Exchange (ETDEWEB)

Cole, James Irvin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

The Nuclear Science User Facilities has been in the process of establishing an innovative Irradiated Materials Library concept for maximizing the value of previous and on-going materials and nuclear fuels irradiation test campaigns, including utilization of real-world components retrieved from current and decommissioned reactors. When the ATR national scientific user facility was established in 2007 one of the goals of the program was to establish a library of irradiated samples for users to access and conduct research through competitively reviewed proposal process. As part of the initial effort, staff at the user facility identified legacy materials from previous programs that are still being stored in laboratories and hot-cell facilities at the INL. In addition other materials of interest were identified that are being stored outside the INL that the current owners have volunteered to enter into the library. Finally, over the course of the last several years, the ATR NSUF has irradiated more than 3500 specimens as part of NSUF competitively awarded research projects. The Logistics of managing this large inventory of highly radioactive poses unique challenges. This document will describe materials in the library, outline the policy for accessing these materials and put forth a strategy for making new additions to the library as well as establishing guidelines for minimum pedigree needed to be included in the library to limit the amount of material stored indefinitely without identified value.

Croatian library leaders’ views on (their library quality

Directory of Open Access Journals (Sweden)

Kornelija Petr Balog

2014-04-01

Full Text Available The purpose of this paper is to determine and describe the library culture in Croatian public libraries. Semi-structured interviews with 14 library directors (ten public and four academic were conducted. The tentative discussion topics were: definition of quality, responsibility for quality, satisfaction with library services, familiarization with user perspective of library and librarians, monitoring of user expectations and opinions. These interviews incorporate some of the findings of the project Evaluation of library and information services: public and academic libraries. The project investigates library culture in Croatian public and academic libraries and their preparedness for activities of performance measurement. The interviews reveal that library culture has changed positively in the past few years and that library leaders have positive attitude towards quality and evaluation activities. Library culture in Croatian libraries is a relatively new concept and as such was not actively developed and/or created. This article looks into the library culture of Croatian libraries, but at the same time investigates whether there is any trace of culture of assessment in them. Also, this article brings the latest update on views, opinions and atmosphere in Croatian public and academic libraries.

Standard Test Method for Electrical Performance of Photovoltaic Cells Using Reference Cells Under Simulated Sunlight

CERN Document Server

American Society for Testing and Materials. Philadelphia

2009-01-01

1.1 This test method covers the determination of the electrical performance of a photovoltaic cell under simulated sunlight by means of a calibrated reference cell procedure. 1.2 Electrical performance measurements are reported with respect to a select set of standard reporting conditions (SRC) (see Table 1) or to user-specified conditions. 1.2.1 The SRC or user-specified conditions include the cell temperature, the total irradiance, and the reference spectral irradiance distribution. 1.3 This test method is applicable only to photovoltaic cells with a linear response over the range of interest. 1.4 The cell parameters determined by this test method apply only at the time of test, and imply no past or future performance level. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this s...

Requests on domestic nuclear data library from BWR design

International Nuclear Information System (INIS)

Maruyama, Hiromi

2003-01-01

Requests on the domestic nuclear data library JENDL and activities of the Nuclear Data Center have been presented from the perspective of BWR design and design code development. The requests include a standard multi-group cross section library, technical supports, and clarification of advantage of JENDL as well as requests from physical aspects. (author)

The University of Canterbury Library (Christchurch, New Zealand

Directory of Open Access Journals (Sweden)

Mojca Jevnikar-Zajc

2002-01-01

Full Text Available Successful performance of study and research programs of individual academic institutions depends on the quality of its support services, including library services. An example of such a service is the University of Canterbury Library in New Zealand,which fulfills its mission and set goals on the basis of international library standards.Adequately furnished areas, well organized work and professional staff enable the library to function successfully. Its work is mainly aimed at user education and information technology development. This is achieved by bringing information closer to the user by means of a well organized communication process, user education for active use of library services, by offering reference and information aid and by enabling different access to information resources and library services. The majority of library services can be processed by users themselves - eg. retrieval, ordering and browsing through materials, the use of electronic resources, information printing, learning how to use library services and resources. The library is an essential part of an information centre of a wider area of the Christchurch and Canterbury region and as such does not serve the students’ needs alone but follows globalisation trends in the field of acquisition, accessibility and information exchange.

Visual characterization and diversity quantification of chemical libraries: 2. Analysis and selection of size-independent, subspace-specific diversity indices.

Science.gov (United States)

Colliandre, Lionel; Le Guilloux, Vincent; Bourg, Stephane; Morin-Allory, Luc

2012-02-27

High Throughput Screening (HTS) is a standard technique widely used to find hit compounds in drug discovery projects. The high costs associated with such experiments have highlighted the need to carefully design screening libraries in order to avoid wasting resources. Molecular diversity is an established concept that has been used to this end for many years. In this article, a new approach to quantify the molecular diversity of screening libraries is presented. The approach is based on the Delimited Reference Chemical Subspace (DRCS) methodology, a new method that can be used to delimit the densest subspace spanned by a reference library in a reduced 2D continuous space. A total of 22 diversity indices were implemented or adapted to this methodology, which is used here to remove outliers and obtain a relevant cell-based partition of the subspace. The behavior of these indices was assessed and compared in various extreme situations and with respect to a set of theoretical rules that a diversity function should satisfy when libraries of different sizes have to be compared. Some gold standard indices are found inappropriate in such a context, while none of the tested indices behave perfectly in all cases. Five DRCS-based indices accounting for different aspects of diversity were finally selected, and a simple framework is proposed to use them effectively. Various libraries have been profiled with respect to more specific subspaces, which further illustrate the interest of the method.

Utah Public Library Trustee Handbook.

Science.gov (United States)

Utah State Library, Salt Lake City.

Designed to answer basic questions and to assist the Utah public library trustee in the performance of his duties, this handbook's brief, informative sections cover efficiency guidelines, policies and procedures, standards, money, personnel services, travel costs, operations, capital outlay, trustee checklist, job description for librarian,…

Functional study and regional mapping of 44 hormono-regulated genes isolated from a porcine granulosa cell library

Directory of Open Access Journals (Sweden)

Hatey François

2001-01-01

Full Text Available Abstract cDNA clones from a pig granulosa cell cDNA library were isolated by differential hybridisation for follicle stimulating hormone (FSH regulation in granulosa cells in a previous study. The clones that did not match any known sequence were studied for their expression in granulosa cells (treated or not by FSH and in fresh isolated ovarian follicles mainly by comparative RT-PCR analysis. These results give functional data on genes that may be implicated in follicular growing. These ESTs have been localised on the porcine genome, using a somatic cell hybrid panel, providing new type I markers on the porcine map and information on the comparative map between humans and pigs.

Cell-free translational screening of an expression sequence tag library of Clonorchis sinensis for novel antigen discovery.

Science.gov (United States)

Kasi, Devi; Catherine, Christy; Lee, Seung-Won; Lee, Kyung-Ho; Kim, Yu Jung; Ro Lee, Myeong; Ju, Jung Won; Kim, Dong-Myung

2017-05-01

The rapidly evolving cloning and sequencing technologies have enabled understanding of genomic structure of parasite genomes, opening up new ways of combatting parasite-related diseases. To make the most of the exponentially accumulating genomic data, however, it is crucial to analyze the proteins encoded by these genomic sequences. In this study, we adopted an engineered cell-free protein synthesis system for large-scale expression screening of an expression sequence tag (EST) library of Clonorchis sinensis to identify potential antigens that can be used for diagnosis and treatment of clonorchiasis. To allow high-throughput expression and identification of individual genes comprising the library, a cell-free synthesis reaction was designed such that both the template DNA and the expressed proteins were co-immobilized on the same microbeads, leading to microbead-based linkage of the genotype and phenotype. This reaction configuration allowed streamlined expression, recovery, and analysis of proteins. This approach enabled us to identify 21 antigenic proteins. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:832-837, 2017. © 2017 American Institute of Chemical Engineers.

Work of the Web Weavers: Web Development in Academic Libraries

Science.gov (United States)

Bundza, Maira; Vander Meer, Patricia Fravel; Perez-Stable, Maria A.

2009-01-01

Although the library's Web site has become a standard tool for seeking information and conducting research in academic institutions, there are a variety of ways libraries approach the often challenging--and sometimes daunting--process of Web site development and maintenance. Three librarians at Western Michigan University explored issues related…

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.

Science.gov (United States)

Lenci, Elena; Innocenti, Riccardo; Biagioni, Alessio; Menchi, Gloria; Bianchini, Francesca; Trabocchi, Andrea

2016-10-20

The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2 H -furo[3,2- b ][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.

Listening to Students: Customer Journey Mapping at Birmingham City University Library and Learning Resources

Science.gov (United States)

Andrews, Judith; Eade, Eleanor

2013-01-01

Birmingham City University's Library and Learning Resources' strategic aim is to improve student satisfaction. A key element is the achievement of the Customer Excellence Standard. An important component of the standard is the mapping of services to improve quality. Library and Learning Resources has developed a methodology to map these…

School Librarian as Inquisitor of Practice: Reimagine, Reflect, and React with the New Standards

Science.gov (United States)

Burns, Elizabeth

2018-01-01

The modern school library is a complex social setting "grounded in standards and best practice" (AASL 2018). The new "National School Library Standards" have refreshed the student learning standards and aligned new Shared Foundations to the school library. Additionally, the competencies for learners are now complemented by…

Conditions of lighting in reading-rooms located in public and school libraries in Silesian Voivodeship

Directory of Open Access Journals (Sweden)

Magdalena Sitek

2013-06-01

Full Text Available Introduction: Reading-room is a place where special lighting conditions are required to make the reader feel comfortable and satisfied.. Lighting requirements are enclosed in the Polish Standard PN-EN 12464-1:2004. Accordingly, illuminance in the reading-rooms should be 500 lx. The aim of the study was to measure illuminance in reading-rooms in various libraries and make relative comparisons to standard values. Material and methods: Measurements of illuminance were performed in 22 reading-rooms in Silesia Voivodeship. Half of them were made in public libraries and half in reading-rooms at junior lower high schools. Illuminance was measured in 5 measurement points in reading-rooms by digital lux meter Lx-105 manufactured by Lutron. Furthermore , 100 readers of school libraries and 89 readers of public libraries completed a questionnaire on lighting conditions in these places. Results: Only 5 out of 22 reading-rooms meet the requirements of the Polish Standard concerning illuminance. Only in one reading room at junior lower high school illuminance exceeded 500 lx. In two other reading places the requirements were met due to additional desk lamps. Despite the results, 76.4% of approached readers of public libraries and 60% of pupils think that lighting in readingrooms is satisfactory and almost 63% of the readers and 53% of the pupils don’t demand additional lighting. Conclusions: Most of the scrutinized reading rooms do not meet lighting requirements according to the Polish Standard. Lighting conditions in school libraries are worse than in public libraries. According to the respondents lighting in public libraries is adequate.

Survey of Integration Cost-Adoption between Digital Library Systems in Iran

Directory of Open Access Journals (Sweden)

Mehdi Alipour-Hafezi

2013-03-01

Full Text Available The main goal of this article was identifying cost elements in syntactic integrating digital library systems in Iran. The levels of integration are content, technical, and organizational. It is obvious we could access some sub goals such as identifying current situation of information systems from the view points of data storage, needed standard outputs, and the current situation of interoperability in Iran, and suitable integration model in Iranian digital libraries. The analytical survey method was used in this research. Research population included 11 digital library systems that were used in Iranian digital libraries. In order to gather information, a researcher made questionnaire was used because of not existing standard collecting data tool. Findings demonstrated that we should search on three levels of interoperability: content, technical, and organizational level in order to identifying cost-adoption elements in syntactic interoperability. Also, findings showed that the elements of organizational level were too important level in cost-adoption elements. Also this research demonstrated that the high cost of adoption was related to libraries and their organizations.

Book Scarcity In Nigerian University Libraries:A Menace To Effective ...

African Journals Online (AJOL)

Book scarcity has persisted due to poor funding of education by Federal Government, frustration of authors, violation of copyright laws and committing of library crimes by library staff and users. This situation has affected educational standards such that over 100 courses offered in the universities in 2005 were refused ...

Web Usability Policies/Standards/Guidelines Do Not Influence Practices at ARL Academic Libraries. A Review of: Chen, Yu‐Hui, Carol Anne Germain and Huahai Yang. “An Exploration into the Practices of Library Web Usability in ARL Academic Libraries.” Journal of the American Society for Information Science and Technology 60.5 (2009: 953‐68.

Directory of Open Access Journals (Sweden)

Shandra Protzko

2009-12-01

Full Text Available Objective – To survey the current status of Web usability Policies/Standards/Guidelines (PSGs found in academic libraries of the Association of Research Libraries (ARL. Researchers sought to investigate whether PSGs are in place, the levels of difficulty surrounding implementation, the impact of PSGs on design, testing, and resource allocation, and the relationship between ARL ranking and usability practice or PSGs.Design – Survey.Setting – North America.Subjects – Academic libraries of the ARL.Methods – An 18‐question survey consisting of multiple choice, Likert scale, and open‐ended questions was sent to all 113 ARL libraries in November 2007. Survey recipients were selected as the person in charge of Web site usability by visiting library Web sites and phone inquiry. The survey was concluded in January 2008 with a response rate of 74% (84 institutions. The researchers used t‐test to detect any difference in ARL library ranking between libraries with and without PSGs. Pair‐wise t‐tests were conducted to identify gaps in difficulty implementing PSGs. In addition, they used Pearson’s Correlation to investigate any significant correlations between variables such as ARL rank and resource allocation.Main Results – Of the 84 respondents, 34 (40% have general library Web PSGs and 25 (30% have specific usability PSGs; 41 (49% have at least one type of in‐library PSG. Of the 43 (51% libraries that do not have PSGs, 30 (36% are at universities with institutional Web usability PSGs; 26 (87% follow those guidelines. There was no statistically significant relationship between ARL ranking and PSG status (see Table 1. The authors asked about difficulty in implementing PSGs. Of the 32 libraries responding to a question about general library Web PSGs, most had slight or moderate difficulty. Twenty‐three libraries with specific usability PSGs identified difficulty levels; some had no difficulty, but a majority had moderate difficulty

Investigations of Laser Pumped Gas Cell Atomic Frequency Standard

National Research Council Canada - National Science Library

Volk, C. H; Camparo, J. C; Frueholz, R. P

1981-01-01

Recently it has been suggested that the performance characteristics of a rubidium gas cell atomic frequency standard might be improved by replacing the standard rubidium discharge lamp with a single mode laser diode...

Application Reuse Library for Software, Requirements, and Guidelines

Science.gov (United States)

Malin, Jane T.; Thronesbery, Carroll

1994-01-01

Better designs are needed for expert systems and other operations automation software, for more reliable, usable and effective human support. A prototype computer-aided Application Reuse Library shows feasibility of supporting concurrent development and improvement of advanced software by users, analysts, software developers, and human-computer interaction experts. Such a library expedites development of quality software, by providing working, documented examples, which support understanding, modification and reuse of requirements as well as code. It explicitly documents and implicitly embodies design guidelines, standards and conventions. The Application Reuse Library provides application modules with Demo-and-Tester elements. Developers and users can evaluate applicability of a library module and test modifications, by running it interactively. Sub-modules provide application code and displays and controls. The library supports software modification and reuse, by providing alternative versions of application and display functionality. Information about human support and display requirements is provided, so that modifications will conform to guidelines. The library supports entry of new application modules from developers throughout an organization. Example library modules include a timer, some buttons and special fonts, and a real-time data interface program. The library prototype is implemented in the object-oriented G2 environment for developing real-time expert systems.

Identification of Novel Human Breast Carcinoma (MDA-MB-231 Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

Directory of Open Access Journals (Sweden)

Elena Lenci

2016-10-01

Full Text Available The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.

Libraries for users services in academic libraries

CERN Document Server

Alvite, Luisa

2010-01-01

This book reviews the quality and evolution of academic library services. It revises service trends offered by academic libraries and the challenge of enhancing traditional ones such as: catalogues, repositories and digital collections, learning resources centres, virtual reference services, information literacy and 2.0 tools.studies the role of the university library in the new educational environment of higher educationrethinks libraries in academic contextredefines roles for academic libraries

Monte Carlo calculation of standard graphite block

International Nuclear Information System (INIS)

Ljubenov, V.

2000-01-01

This paper presents results of calculation of neutron flux space and energy distribution in the standard graphite block (SGB) obtained by the MCNP TM code. VMCCS nuclear data library, based on the ENDF / B-VI release 4 evaluation file, is used. MCNP model of the SGB considers detailed material, geometric and spectral properties of the neutron source, source carrier, graphite moderator medium, aluminium foil holders and proximate surrounding of SGB Geometric model is organised to provide the simplest homogeneous volume cells in order to obtain the maximum acceleration of neutron history tracking (author)

Effects of nuclear data library on BFS and ZPPR fast reactor core analysis results. Pt. 1. ZPPR analysis results

International Nuclear Information System (INIS)

Mantourov, Guennadi

2001-05-01

This work was fulfilled in the frame of JNC-IPPE Collaboration on Experimental Investigation of Excess of Weapon Pu Disposition in BN-600 Reactor Using BFS-2 Facility. The data processing system CONSYST/ABBN coupled with ABBN-93 nuclear data library was used in analysis of BFS and ZPPR fast reactor cores applying JNC core calculation code CITATION. FFCP cell code was used for taking into account the spatial cell heterogeneity and resonance effects based on the first flight collision probability method and subgroup approach. Especially a converting program was written to transmit the prepared effective cross sections to JNC standard PDS files. Then the CITATION code was applied for 3-D XYZ neutronics calculations of BFS and ZPPR JUPITER experiments series cores. The effects of nuclear data library have been studied by comparing the former results based on JENDL-3.2 nuclear data library. The comparison results using IPPE and JNC nuclear data libraries for k-effective parameter for ZPPR-9, ZPPR-13A and ZPPR-17A cores are presented. The calculated correction factor in all cases was less than 1.0%. So the uncertainty in C value caused by possible errors in calculation of these corrections is expected to be less than 0.3% in case of ZPPR-13A and ZPPR-17A cores, and rather less for ZPPR-9 core. The main result of this study is that the effect of applying ABBN-93 nuclear data in JNC calculation route revealed a large enough discrepancy in k-eff for ZPPR-9 (about 0.6%) and ZPPR-17A (about 0.5%) cores. For BFS-62-1 and BFS-62-2 cores such analysis is in progress. Stretch cell models for both BFS cores were formed and cell calculations using FFCP code have started. Some results of cell calculations are presented. (author)

Construction of High-Quality Camel Immune Antibody Libraries.

Science.gov (United States)

Romão, Ema; Poignavent, Vianney; Vincke, Cécile; Ritzenthaler, Christophe; Muyldermans, Serge; Monsion, Baptiste

2018-01-01

Single-domain antibodies libraries of heavy-chain only immunoglobulins from camelids or shark are enriched for high-affinity antigen-specific binders by a short in vivo immunization. Thus, potent binders are readily retrieved from relatively small-sized libraries of 10 7 -10 8 individual transformants, mostly after phage display and panning on a purified target. However, the remaining drawback of this strategy arises from the need to generate a dedicated library, for nearly every envisaged target. Therefore, all the procedures that shorten and facilitate the construction of an immune library of best possible quality are definitely a step forward. In this chapter, we provide the protocol to generate a high-quality immune VHH library using the Golden Gate Cloning strategy employing an adapted phage display vector where a lethal ccdB gene has to be substituted by the VHH gene. With this procedure, the construction of the library can be shortened to less than a week starting from bleeding the animal. Our libraries exceed 10 8 individual transformants and close to 100% of the clones harbor a phage display vector having an insert with the length of a VHH gene. These libraries are also more economic to make than previous standard approaches using classical restriction enzymes and ligations. The quality of the Nanobodies that are retrieved from immune libraries obtained by Golden Gate Cloning is identical to those from immune libraries made according to the classical procedure.

Endf/B-VII.0 Based Library for Paragon - 313

International Nuclear Information System (INIS)

Huria, H.C.; Kucukboyaci, V.N.; Ouisloumen, M.

2010-01-01

A new 70-group library has been generated for the Westinghouse lattice physics code PARAGON using the ENDF/B-VII.0 nuclear data files. The new library retains the major features of the current library, including the number of energy groups and the reduction in the U-238 resonance integral. The upper bound for the up-scattering effects in the new library, however, has been moved to 4.0 eV from 2.1 eV for better MOX fuel predictions. The new library has been used to analyze standard benchmarks and also to compare the measured and predicted parameters for different types of Westinghouse and Combustion Engineering (CE) type operating reactor cores. Results indicate that the new library will not impact the reactivity, power distribution and the temperature coefficient predictions over a wide range of physics design parameters; however, will improve the MOX core predictions. In other words, the ENDF/B-VI.3 and ENDF/B-VII.0 produce similar results for reactor core calculations. (authors)

ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Science.gov (United States)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M.-A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Energy Technology Data Exchange (ETDEWEB)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M. -A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

SCHOOL COMMUNITY PERCEPTION OF LIBRARY APPS AGAINTS LIBRARY EMPOWERMENT

Directory of Open Access Journals (Sweden)

Achmad Riyadi Alberto

2017-07-01

Full Text Available Abstract. This research is motivated by the development of information and communication technology (ICT in the library world so rapidly that allows libraries in the present to develop its services into digital-based services. This study aims to find out the school community’s perception of library apps developed by Riche Cynthia Johan, Hana Silvana, and Holin Sulistyo and its influence on library empowerment at the library of SD Laboratorium Percontohan UPI Bandung. Library apps in this research belong to the context of m-libraries, which is a library that meets the needs of its users by using mobile platforms such as smartphones,computers, and other mobile devices. Empowerment of library is the utilization of all aspects of the implementation of libraries to the best in order to achieve the expected goals. An analysis of the schoolcommunity’s perception of library apps using the Technology Acceptance Model (TAM includes: ease of use, usefulness, usability, usage trends, and real-use conditions. While the empowerment of the library includes aspects: information empowerment, empowerment of learning resources, empowerment of human resources, empowerment of library facilities, and library promotion. The research method used in this research is descriptive method with quantitative approach. Population and sample in this research is school community at SD Laboratorium Percontohan UPI Bandung. Determination of sample criteria by using disproportionate stratified random sampling with the number of samples of 83 respondents. Data analysis using simple linear regression to measure the influence of school community perception about library apps to library empowerment. The result of data analysis shows that there is influence between school community perception about library apps to library empowerment at library of SD Laboratorium Percontohan UPI Bandung which is proved by library acceptance level and library empowerment improvement.

Sign Redesign: Applying Design Principles to Improve Signage in an Academic Library

Directory of Open Access Journals (Sweden)

Sheila Kasperek

2014-05-01

Full Text Available When the Mansfield University library’s Special Events and Customer Service Committee created a communications plan for the library, the opportunity presented itself to overhaul the library signs. Applying basic design principles of contrast, alignment, and repetition along with standards from the Americans with Disabilities Act, the library improved the visual communications within the library. Patrons can now read signs from a distance and understand their purpose. Using common design elements, the library began presenting official library information more cohesively. Extending beyond signs, these design principles are now part of the library’s print publications and promotional items. With this consistency, the library brand is more easily recognizable both within the library and across campus. This article describes some basic elements of design and the process of redesigning the signs.

Differential screening of phage-ab libraries by oligonucleotide microarray technology.

Directory of Open Access Journals (Sweden)

Paolo Monaci

Full Text Available A novel and efficient tagArray technology was developed that allows rapid identification of antibodies which bind to receptors with a specific expression profile, in the absence of biological information. This method is based on the cloning of a specific, short nucleotide sequence (tag in the phagemid coding for each phage-displayed antibody fragment (phage-Ab present in a library. In order to set up and validate the method we identified about 10,000 different phage-Abs binding to receptors expressed in their native form on the cell surface (10 k Membranome collection and tagged each individual phage-Ab. The frequency of each phage-Ab in a given population can at this point be inferred by measuring the frequency of its associated tag sequence through standard DNA hybridization methods. Using tiny amounts of biological samples we identified phage-Abs binding to receptors preferentially expressed on primary tumor cells rather than on cells obtained from matched normal tissues. These antibodies inhibited cell proliferation in vitro and tumor development in vivo, thus representing therapeutic lead candidates.

Validation of the 172 group ENDFB7GX library

International Nuclear Information System (INIS)

Khan, Suhail Ahmad; Raj, Devesh; Karthikeyan, R.; Jagannathan, V.

2007-01-01

Full text: Five 172 group libraries, viz., IAEAGX, ENDFB6GX, JENDL3GX, JEFF31GX, and LWRPSGX were obtained as a part of the IAEA WIMS Library Update Project (WLUP). The first four libraries have data available for 173 nuclides up to 244 Cm. The LWRPSGX library based on JEFF3.1 point dataset is an extended library up to 252 Cf. Data for 12 more actinides and the related burnup chain were added. The five libraries were validated against known experiments in an earlier work. In general the LWRPSGX was found to be giving better results. Recently another version of 172 group library 'ENDFB7GX' has been released. In the present work we provide the results of validation of the ENDFB7GX library against the same set of experimental data and a comparison with results of other libraries. The experimental configuration data include a variety of uniform lattices with enriched UO 2 , U- metal, mixed oxide (UO 2 -PuO 2 ) fuels with H 2 O and D 2 O moderators for a wide range of enrichment, fuel diameter and ratio of moderator to fuel volume (V m /V f ). The calculations have been done using the code LATTEST which solves the single pin lattice cell problem by 1-D multi-group transport theory after cylindricalising the square or hexagonal cell boundary. The LATTEST code is an improved version of the MURLI code and is capable of providing a ready testing of any new cross section library against a set of experimental benchmark lattices collected from various sources. The calculated k eff values and certain spectral indices, where available, have been compared for all the libraries for more than hundred critical lattices. There is a general under prediction of k eff values by all libraries. The maximum under prediction is for ENDFB6GX library and the least is for JENDL3GX library. The ENDFB7GX library, in general, is found to over predict in comparison to the k eff values obtained using LWRPSGX library. While scrutinizing the basic nuclear data it was noted that the slowing down cross

The Problem Patron: Is There One in Your Library?

Science.gov (United States)

Chattoo, Calmer D.

2002-01-01

Discusses the history of problem patrons in libraries and explains various types of problem patrons and their identifying behavior. Highlights include senior citizens; technology-created problems, such as users with cell phones; eccentric behavior; non-compliance with library rules; harassment; intentional bad behavior such as theft; and problems…

The Medical Library Association Benchmarking Network: results.

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C; Smith, Bernie Todd

2006-04-01

This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries.

The Medical Library Association Benchmarking Network: results*

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article presents some limited results from the Medical Library Association (MLA) Benchmarking Network survey conducted in 2002. Other uses of the data are also presented. Methods: After several years of development and testing, a Web-based survey opened for data input in December 2001. Three hundred eighty-five MLA members entered data on the size of their institutions and the activities of their libraries. The data from 344 hospital libraries were edited and selected for reporting in aggregate tables and on an interactive site in the Members-Only area of MLANET. The data represent a 16% to 23% return rate and have a 95% confidence level. Results: Specific questions can be answered using the reports. The data can be used to review internal processes, perform outcomes benchmarking, retest a hypothesis, refute a previous survey findings, or develop library standards. The data can be used to compare to current surveys or look for trends by comparing the data to past surveys. Conclusions: The impact of this project on MLA will reach into areas of research and advocacy. The data will be useful in the everyday working of small health sciences libraries as well as provide concrete data on the current practices of health sciences libraries. PMID:16636703

The National and University Library in Zagreb: The Goal Is Known--How Can It Be Attained?

Science.gov (United States)

Miletic-Vejzovic, Laila

1994-01-01

Provides an overview of the state of libraries and their resources in Croatia. Highlights include destruction of libraries resulting from the war; the need for centralization, uniformity, and standards; the role of the National and University Library; processing library materials; and the development of an automated system and network. (Contains…

Welcome to the National Wetlands Research Center Library: Not Just Another Library-A Special Library

Science.gov (United States)

Broussard, Linda

2007-01-01

Libraries are grouped into four major types: public, school, academic, and special. The U.S. Geological Survey's (USGS) National Wetlands Research Center (NWRC) library is classified as a special library because it is sponsored by the Federal government, and the collections focus on a specific subject. The NWRC library is the only USGS library dedicated to wetland science. Library personnel offer expert research services to meet the informational needs of NWRC scientists, managers, and support personnel. The NWRC library participates in international cataloging and resource sharing, which allows libraries from throughout the world to borrow from its collections. This sharing facilitates the research of other governmental agencies, universities, and those interested in the study of wetlands.

One-group constant libraries for nuclear equilibrium state

Energy Technology Data Exchange (ETDEWEB)

Mizutani, Akihiko; Sekimoto, Hiroshi [Tokyo Inst. of Tech. (Japan). Research Lab. for Nuclear Reactors

1997-03-01

One-group constant libraries for the nuclear equilibrium state were generated for both liquid sodium cooled MOX fuel type fast reactor and PWR type thermal reactor with Equilibrium Cell Iterative Calculation System (ECICS) using JENDL-3.2, -3, -2 and ENDF/B-VI nuclear data libraries. ECICS produced one-group constant sets for 129 heavy metal nuclides and 1238 fission products. (author)

Library construction and evaluation for site saturation mutagenesis.

Science.gov (United States)

Sullivan, Bradford; Walton, Adam Z; Stewart, Jon D

2013-06-10

We developed a method for creating and evaluating site-saturation libraries that consistently yields an average of 27.4±3.0 codons of the 32 possible within a pool of 95 transformants. This was verified by sequencing 95 members from 11 independent libraries within the gene encoding alkene reductase OYE 2.6 from Pichia stipitis. Correct PCR primer design as well as a variety of factors that increase transformation efficiency were critical contributors to the method's overall success. We also developed a quantitative analysis of library quality (Q-values) that defines library degeneracy. Q-values can be calculated from standard fluorescence sequencing data (capillary electropherograms) and the degeneracy predicted from an early stage of library construction (pooled plasmids from the initial transformation) closely matched that observed after ca. 1000 library members were sequenced. Based on this experience, we suggest that this analysis can be a useful guide when applying our optimized protocol to new systems, allowing one to focus only on good-quality libraries and reject substandard libraries at an early stage. This advantage is particularly important when lower-throughput screening techniques such as chiral-phase GC must be employed to identify protein variants with desirable properties, e.g., altered stereoselectivities or when multiple codons are targeted for simultaneous randomization. Copyright © 2013 Elsevier Inc. All rights reserved.

Know Thy Neighbor: Crypto Library Detection in Cloud

Directory of Open Access Journals (Sweden)

Irazoqui Gorka

2015-04-01

Full Text Available Software updates and security patches have become a standard method to fix known and recently discovered security vulnerabilities in deployed software. In server applications, outdated cryptographic libraries allow adversaries to exploit weaknesses and launch attacks with significant security results. The proposed technique exploits leakages at the hardware level to first, determine if a specific cryptographic library is running inside (or not a co-located virtual machine (VM and second to discover the IP of the co-located target. To this end, we use a Flush+Reload cache side-channel technique to measure the time it takes to call (load a cryptographic library function. Shorter loading times are indicative of the library already residing in memory and shared by the VM manager through deduplication. We demonstrate the viability of the proposed technique by detecting and distinguishing various cryptographic libraries, including MatrixSSL, PolarSSL, GnuTLS, OpenSSL and CyaSSL along with the IP of the VM running these libraries. In addition, we show how to differentiate between various versions of libraries to better select an attack target as well as the applicable exploit. Our experiments show a complete attack setup scenario with single-trial success rates of up to 90% under light load and up to 50% under heavy load for libraries running in KVM.

Assessing Library Automation and Virtual Library Development in Four Academic Libraries in Oyo, Oyo State, Nigeria

Science.gov (United States)

Gbadamosi, Belau Olatunde

2011-01-01

The paper examines the level of library automation and virtual library development in four academic libraries. A validated questionnaire was used to capture the responses from academic librarians of the libraries under study. The paper discovers that none of the four academic libraries is fully automated. The libraries make use of librarians with…

Library correlation nuclide identification algorithm

International Nuclear Information System (INIS)

Russ, William R.

2007-01-01

A novel nuclide identification algorithm, Library Correlation Nuclide Identification (LibCorNID), is proposed. In addition to the spectrum, LibCorNID requires the standard energy, peak shape and peak efficiency calibrations. Input parameters include tolerances for some expected variations in the calibrations, a minimum relative nuclide peak area threshold, and a correlation threshold. Initially, the measured peak spectrum is obtained as the residual after baseline estimation via peak erosion, removing the continuum. Library nuclides are filtered by examining the possible nuclide peak areas in terms of the measured peak spectrum and applying the specified relative area threshold. Remaining candidates are used to create a set of theoretical peak spectra based on the calibrations and library entries. These candidate spectra are then simultaneously fit to the measured peak spectrum while also optimizing the calibrations within the bounds of the specified tolerances. Each candidate with optimized area still exceeding the area threshold undergoes a correlation test. The normalized Pearson's correlation value is calculated as a comparison of the optimized nuclide peak spectrum to the measured peak spectrum with the other optimized peak spectra subtracted. Those candidates with correlation values that exceed the specified threshold are identified and their optimized activities are output. An evaluation of LibCorNID was conducted to verify identification performance in terms of detection probability and false alarm rate. LibCorNID has been shown to perform well compared to standard peak-based analyses

Microaspiration of esophageal gland cells and cDNA library construction for identifying parasitism genes of plant-parasitic nematodes.

Science.gov (United States)

Hussey, Richard S; Huang, Guozhong; Allen, Rex

2011-01-01

Identifying parasitism genes encoding proteins secreted from a plant-parasitic nematode's esophageal gland cells and injected through its stylet into plant tissue is the key to understanding the molecular basis of nematode parasitism of plants. Parasitism genes have been cloned by directly microaspirating the cytoplasm from the esophageal gland cells of different parasitic stages of cyst or root-knot nematodes to provide mRNA to create a gland cell-specific cDNA library by long-distance reverse-transcriptase polymerase chain reaction. cDNA clones are sequenced and deduced protein sequences with a signal peptide for secretion are identified for high-throughput in situ hybridization to confirm gland-specific expression.

Excellence in the stacks strategies, practices and reflections of award-winning libraries

CERN Document Server

Hill, Jacob

2013-01-01

Excellence in the Stacks details the philosophies, practices and innovations of award-winning libraries over the last ten years. It will inform the profession and highlight the themes and strategies these liberal-arts colleges share, and where they differ. Using the Association of Research and College Libraries Excellence in Academic Libraries Award standards as guidelines for exploring librarianship, this book gathers the perspectives of all types of librarians at all levels of employment. By highlighting winners' holistic approaches it helps define and focus the energies of college libraries

A Polymerase Chain Reaction-Based Method for Isolating Clones from a Complimentary DNA Library in Sheep

Science.gov (United States)

Friis, Thor Einar; Stephenson, Sally; Xiao, Yin; Whitehead, Jon

2014-01-01

The sheep (Ovis aries) is favored by many musculoskeletal tissue engineering groups as a large animal model because of its docile temperament and ease of husbandry. The size and weight of sheep are comparable to humans, which allows for the use of implants and fixation devices used in human clinical practice. The construction of a complimentary DNA (cDNA) library can capture the expression of genes in both a tissue- and time-specific manner. cDNA libraries have been a consistent source of gene discovery ever since the technology became commonplace more than three decades ago. Here, we describe the construction of a cDNA library using cells derived from sheep bones based on the pBluescript cDNA kit. Thirty clones were picked at random and sequenced. This led to the identification of a novel gene, C12orf29, which our initial experiments indicate is involved in skeletal biology. We also describe a polymerase chain reaction-based cDNA clone isolation method that allows the isolation of genes of interest from a cDNA library pool. The techniques outlined here can be applied in-house by smaller tissue engineering groups to generate tools for biomolecular research for large preclinical animal studies and highlights the power of standard cDNA library protocols to uncover novel genes. PMID:24447069

Workplace culture in academic libraries the early 21st century

CERN Document Server

Blessinger, Kelly

2013-01-01

Workplace culture refers to conditions that collectively influence the work atmosphere. These can include policies, norms, and unwritten standards for behavior. This book focuses on various aspects of workplace culture in academic libraries from the practitioners' viewpoint, as opposed to that of the theoretician. The book asks the following questions: What conditions contribute to an excellent academic library work environment? What helps to make a particular academic library a great place to work? Articles focus on actual programs while placing the discussion in a scholarly context. The book

MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARIES: A ...

African Journals Online (AJOL)

MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARIES: A TOOL FOR SURVIVAL IN THE ... This article discusses the concept of marketing library and information services as an ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

Methodological fragments for the planning and decision making related to library utomation projects

Directory of Open Access Journals (Sweden)

Wanda Maria Maia da Rocha Paranhos

2004-01-01

Full Text Available Library automation processes depend in part in taking decisions on aspects of information and communications technologies (ICTs such as operational software, application software, data base management systems, hardware and communication network. The process depend also on decisions taken on Library Science aspects, specially in relation to the creation and management of bibliographic data which support services provision, such as the funcionalities included in applications software and how software implement desirable standards. The more important standards are AACR2, MARC/XML, ISO2709 and z39.50 communication protocol. Commitment to those standards tend to impact favorably on projects final costs. The cost of construction bibliographic data base may be the more expensive element item in the whole project; that can be minimized with use of cited standards and free bibliographic information available in Internet. The bigger the library holding, the more expressive the economy on this item with this methodology, which allows for full observation of local guidelines for the database construction. A synthetic list of the variety of product solutions available in Brazil is presented appended to the article, as well as an example of a basic request list of items to observe or evaluate in integrated library systems.

The Cambridge crystallography subroutine library

International Nuclear Information System (INIS)

Brown, P.J.; Matthewman, J.C.

1981-06-01

This manual is an amalgamation of the original Cambridge Crystallography Subroutine Library Mark II manual and its supplement No I. The original Mark II system, a set of FORTRAN Subroutines which can be used for standard crystallographic calculations, has been extended to include facilities for conventional least squares refinement. Several new routines have also been added. (U.K.)

图书馆标准体系构建的理论依据、参照指标与建设基础%A Study on Theoretical Basis, Reference Points of Ideas and Foundation of Stan-dards for Libraries

Institute of Scientific and Technical Information of China (English)

周文杰

2016-01-01

This study conducted a systematic analysis of the constructing of the standard and norm system of library through perspectives of theoretical basis, reference points of ideas and foundations. Form the perspective of theoretical basis, Three Worlds Theory which developed by Karl R. Popper explained the possibilities, Five Laws of Library Sci-ence which issued by S. R. Ranganathan explained the necessity, and social epistemology explained the feasibility of the standard system of library. Besides, ideas from the library related standard which conducted by ISO and IFLA and some quality evaluation program provided reference points for library standard in China. Social foundation, professional foun-dation, policy foundation and methodology foundation should be the essential foundation of the construction of library standard and norms in China.%文章从理论依据、参照标准和建设基础三个方面对我国图书馆标准体系构建展开了分析。就图书馆标准体系的理论依据而言，“世界三”理论解释了其可能性，“图书馆学五定律”解释了其必要性，而“社会认识论”解释了其现实性。ISO及IFLA所制定的与图书馆相关的标准及国际图书馆界开展的若干质量评估项目及其体现的理念为构建我国图书馆标准体系提供了参照。我国图书馆标准体系的构建已具备了社会、职业、政策和方法论的基础。

Makerspaces in the Library: Science in a Student's Hands

Science.gov (United States)

Julian, Kristi D.; Parrott, Deborah J.

2017-01-01

Makerspaces supply a venue for students to construct a variety of real-world products at the collegiate level using science and technology standards. The maker movement is sweeping the science learning community by storm in the library setting with remarkable success. The maker movement provides an opportunity to transform the library into a…

International Society for the Advancement of Cytometry cell sorter biosafety standards.

Science.gov (United States)

Holmes, Kevin L; Fontes, Benjamin; Hogarth, Philip; Konz, Richard; Monard, Simon; Pletcher, Charles H; Wadley, Robert B; Schmid, Ingrid; Perfetto, Stephen P

2014-05-01

Flow cytometric cell sorting of biological specimens has become prevalent in basic and clinical research laboratories. These specimens may contain known or unknown infectious agents, necessitating precautions to protect instrument operators and the environment from biohazards arising from the use of sorters. To this end the International Society of Analytical Cytology (ISAC) was proactive in establishing biosafety guidelines in 1997 (Schmid et al., Cytometry 1997;28:99-117) and subsequently published revised biosafety standards for cell sorting of unfixed samples in 2007 (Schmid et al., Cytometry Part A J Int Soc Anal Cytol 2007;71A:414-437). Since their publication, these documents have become recognized worldwide as the standard of practice and safety precautions for laboratories performing cell sorting experiments. However, the field of cytometry has progressed since 2007, and the document requires an update. The new Standards provides guidance: (1) for laboratory design for cell sorter laboratories; (2) for the creation of laboratory or instrument specific Standard Operating Procedures (SOP); and (3) on procedures for the safe operation of cell sorters, including personal protective equipment (PPE) and validation of aerosol containment. Published © 2014 Wiley Periodicals Inc.

Thermal reactor benchmark testing of 69 group library

International Nuclear Information System (INIS)

Liu Guisheng; Wang Yaoqing; Liu Ping; Zhang Baocheng

1994-01-01

Using a code system NSLINK, AMPX master library in WIMS 69 groups structure are made from nuclides relating to 4 newest evaluated nuclear data libraries. Some integrals of 10 thermal reactor benchmark assemblies recommended by the U.S. CSEWG are calculated using rectified PASC-1 code system and compared with foreign results, the authors results are in good agreement with others. 69 group libraries of evaluated data bases in TPFAP interface file are generated with NJOY code system. The k ∞ values of 6 cell lattice assemblies are calculated by the code CBM. The calculated results are analysed and compared

Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library

Science.gov (United States)

Sahin, Deniz; Taflan, Sevket Onur; Yartas, Gizem; Ashktorab, Hassan; Smoot, Duane T

2018-04-25

Background: Gastric cancer is the second most common cancer among the malign cancer types. Inefficiency of traditional techniques both in diagnosis and therapy of the disease makes the development of alternative and novel techniques indispensable. As an alternative to traditional methods, tumor specific targeting small peptides can be used to increase the efficiency of the treatment and reduce the side effects related to traditional techniques. The aim of this study is screening and identification of individual peptides specifically targeted to human gastric cancer cells using a phage-displayed peptide library and designing specific peptide sequences by using experimentally-eluted peptide sequences. Methods: Here, MKN-45 human gastric cancer cells and HFE-145 human normal gastric epithelial cells were used as the target and control cells, respectively. 5 rounds of biopannning with a phage display 12-peptide library were applied following subtraction biopanning with HFE-145 control cells. The selected phage clones were established by enzyme-linked immunosorbent assay and immunofluorescence detection. We first obtain random phage clones after five biopanning rounds, determine the binding levels of each individual clone. Then, we analyze the frequencies of each amino acid in best binding clones to determine positively overexpressed amino acids for designing novel peptide sequences. Results: DE532 (VETSQYFRGTLS) phage clone was screened positive, showing specific binding on MKN-45 gastric cancer cells. DE-Obs (HNDLFPSWYHNY) peptide, which was designed by using amino acid frequencies of experimentally selected peptides in the 5th round of biopanning, showed specific binding in MKN-45 cells. Conclusion: Selection and characterization of individual clones may give us specifically binding peptides, but more importantly, data extracted from eluted phage clones may be used to design theoretical peptides with better binding properties than even experimentally selected ones

cDNA library information - Dicty_cDB | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us Dicty_cDB cDNA library information Data detail Data name cDNA library information DOI 10.189...s Data item Description cDNA library name Names of cDNA libraries (AF, AH, CF, CH, FC, FC-IC, FCL, SF, SH, S...(C) 5) sexually fusion-competent KAX3 cells (Gamete phase) (F) cDNA library construction method How to construct cDNA library...dir) 2) Full-length cDNA libraries (oligocapped method)(fl) 3) Gamete-specific subtraction library (sub) cDNA library... construction protocol Link to the webpage describing the protocol for generating cDNA library Size

Portable Instrumented Communication Library

International Nuclear Information System (INIS)

Geist, G.A.; Heath, M.T.; Peyton, B.W.; Worley, P.H.

2001-01-01

1 - Description of program or function: PICL is a subroutine library that can be used to develop parallel programs that are portable across several distributed-memory multi-processors. PICL provides a portable syntax for key communication primitives and related system calls. It also provides portable routines to perform certain widely- used, high-level communication operations, such as global broadcast and global summation. PICL provides execution tracing that can be used to monitor performance or to aid in debugging. 2 - Restrictions on the complexity of the problem: PICL is a compatibility library built on top of the native multiprocessor operating system and message passing primitives. Thus, the portability of PICL programs is not guaranteed, being a function of idiosyncrasies of the different platforms. Predictable differences are captured with standard error trapping routines. PICL is a research tool, not a production software system

CPL: Common Pipeline Library

Science.gov (United States)

ESO CPL Development Team

2014-02-01

The Common Pipeline Library (CPL) is a set of ISO-C libraries that provide a comprehensive, efficient and robust software toolkit to create automated astronomical data reduction pipelines. Though initially developed as a standardized way to build VLT instrument pipelines, the CPL may be more generally applied to any similar application. The code also provides a variety of general purpose image- and signal-processing functions, making it an excellent framework for the creation of more generic data handling packages. The CPL handles low-level data types (images, tables, matrices, strings, property lists, etc.) and medium-level data access methods (a simple data abstraction layer for FITS files). It also provides table organization and manipulation, keyword/value handling and management, and support for dynamic loading of recipe modules using programs such as EsoRex (ascl:1504.003).

Manual for Assessing the Quality of Health Sciences Libraries in Hospitals.

Science.gov (United States)

Bain, Christine A.; And Others

In compliance with legislation enacted by New York State in 1981, a manual of recommendations and standards for hospital libraries was developed (1) to assist in assessment of the quality of hospital library services; (2) to enable measurement of the improvement in individual institutions; and (3) to be used as criteria in the administration of…

Libraries Today, Libraries Tomorrow: Contemporary Library Practices and the Role of Library Space in the L

Directory of Open Access Journals (Sweden)

Ana Vogrinčič Čepič

2013-09-01

Full Text Available ABSTRACTPurpose: The article uses sociological concepts in order to rethink the changes in library practices. Contemporary trends are discussed with regard to the changing nature of working habits, referring mostly to the new technology, and the (emergence of the third space phenomenon. The author does not regard libraries only as concrete public service institutions, but rather as complex cultural forms, taking in consideration wider social context with a stress on users’ practices in relation to space.Methodology/approach: The article is based on the (self- observation of the public library use, and on the (discourse analysis of internal library documents (i.e. annual reports and plans and secondary sociological literature. As such, the cultural form approach represents a classic method of sociology of culture.Results: The study of relevant material in combination with direct personal experiences reveals socio-structural causes for the change of users’ needs and habits, and points at the difficulty of spatial redefinition of libraries as well as at the power of the discourse.Research limitations: The article is limited to an observation of users’ practices in some of the public libraries in Ljubljana and examines only a small number of annual reports – the discoveries are then further debated from the sociological perspective.Originality/practical implications: The article offers sociological insight in the current issues of the library science and tries to suggest a wider explanation that could answer some of the challenges of the contemporary librarianship.

National Libraries Section. General Research Libraries Division. Papers.

Science.gov (United States)

International Federation of Library Associations, The Hague (Netherlands).

Papers on national library services and activities, which were presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "The National Library of China in its Gradual Application of Modern Technology," a discussion by Zhu Nan and Zhu Yan (China) of microform usage and library automation; (2)…

We are planning a library

Directory of Open Access Journals (Sweden)

Silva Novljan

2000-01-01

Full Text Available The article presents the procedures for planning a library, which must fulfil its mission: to enable free access to information, education and culture for everyone at any tirne. The aim of the described procedure is to test the usefulness and appropriateness of professional recommendations for planning, in order to support rational organisation for a maximal effect. A planning model is being set up which would enable the procedures to be repeated and verified on other local communities. It was developed on the basis of a performed analysis of a situation and a chosen case from that situation: a local self-governing community which already has, according to the recommen¬dations of the standards, the necessary conditions to establish a library.

Technical Considerations for Reduced Representation Bisulfite Sequencing with Multiplexed Libraries

Science.gov (United States)

Chatterjee, Aniruddha; Rodger, Euan J.; Stockwell, Peter A.; Weeks, Robert J.; Morison, Ian M.

2012-01-01

Reduced representation bisulfite sequencing (RRBS), which couples bisulfite conversion and next generation sequencing, is an innovative method that specifically enriches genomic regions with a high density of potential methylation sites and enables investigation of DNA methylation at single-nucleotide resolution. Recent advances in the Illumina DNA sample preparation protocol and sequencing technology have vastly improved sequencing throughput capacity. Although the new Illumina technology is now widely used, the unique challenges associated with multiplexed RRBS libraries on this platform have not been previously described. We have made modifications to the RRBS library preparation protocol to sequence multiplexed libraries on a single flow cell lane of the Illumina HiSeq 2000. Furthermore, our analysis incorporates a bioinformatics pipeline specifically designed to process bisulfite-converted sequencing reads and evaluate the output and quality of the sequencing data generated from the multiplexed libraries. We obtained an average of 42 million paired-end reads per sample for each flow-cell lane, with a high unique mapping efficiency to the reference human genome. Here we provide a roadmap of modifications, strategies, and trouble shooting approaches we implemented to optimize sequencing of multiplexed libraries on an a RRBS background. PMID:23193365

Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening.

Directory of Open Access Journals (Sweden)

Hye-Ji Choi

Full Text Available Immunoglobulin Fc heterodimers, which are useful scaffolds for the generation of bispecific antibodies, have been mostly generated through structure-based rational design methods that introduce asymmetric mutations into the CH3 homodimeric interface to favor heterodimeric Fc formation. Here, we report an approach to generate heterodimeric Fc variants through directed evolution combined with yeast surface display. We developed a combinatorial heterodimeric Fc library display system by mating two haploid yeast cell lines, one haploid cell line displayed an Fc chain library (displayed FcCH3A with mutations in one CH3 domain (CH3A on the yeast cell surface, and the other cell line secreted an Fc chain library (secreted FcCH3B with mutations in the other CH3 domain (CH3B. In the mated cells, secreted FcCH3B is displayed on the cell surface through heterodimerization with the displayed FcCH3A, the detection of which enabled us to screen the library for heterodimeric Fc variants. We constructed combinatorial heterodimeric Fc libraries with simultaneous mutations in the homodimer-favoring electrostatic interaction pairs K370-E357/S364 or D399-K392/K409 at the CH3 domain interface. High-throughput screening of the libraries using flow cytometry yielded heterodimeric Fc variants with heterodimer-favoring CH3 domain interface mutation pairs, some of them showed high heterodimerization yields (~80-90% with previously unidentified CH3 domain interface mutation pairs, such as hydrogen bonds and cation-π interactions. Our study provides a new approach for engineering Fc heterodimers that could be used to engineer other heterodimeric protein-protein interactions through directed evolution combined with yeast surface display.

Epitope selection from an uncensored peptide library displayed on avian leukosis virus

International Nuclear Information System (INIS)

Khare, Pranay D.; Rosales, Ana G.; Bailey, Kent R.; Russell, Stephen J.; Federspiel, Mark J.

2003-01-01

Phage display libraries have provided an extraordinarily versatile technology to facilitate the isolation of peptides, growth factors, single chain antibodies, and enzymes with desired binding specificities or enzymatic activities. The overall diversity of peptides in phage display libraries can be significantly limited by Escherichia coli protein folding and processing machinery, which result in sequence censorship. To achieve an optimal diversity of displayed eukaryotic peptides, the library should be produced in the endoplasmic reticulum of eukaryotic cells using a eukaryotic display platform. In the accompanying article, we presented experiments that demonstrate that polypeptides of various sizes could be efficiently displayed on the envelope glycoproteins of a eukaryotic virus, avian leukosis virus (ALV), and the displayed polypeptides could efficiently attach to cognate receptors without interfering with viral attachment and entry into susceptible cells. In this study, methods were developed to construct a model library of randomized eight amino acid peptides using the ALV eukaryotic display platform and screen the library for specific epitopes using immobilized antibodies. A virus library with approximately 2 x 10 6 different members was generated from a plasmid library of approximately 5 x 10 6 diversity. The sequences of the randomized 24 nucleotide/eight amino acid regions of representatives of the plasmid and virus libraries were analyzed. No significant sequence censorship was observed in producing the virus display library from the plasmid library. Different populations of peptide epitopes were selected from the virus library when different monoclonal antibodies were used as the target. The results of these two studies clearly demonstrate the potential of ALV as a eukaryotic platform for the display and selection of eukaryotic polypeptides libraries

LIBRARY SKILL INSTRUCTION IN NIGERIAN ACADEMIC LIBRARIES

African Journals Online (AJOL)

DJFLEX

www.globaljournalseries.com; Info@globaljournalseries.com. LIBRARY SKILL INSTRUCTION IN NIGERIAN ACADEMIC. LIBRARIES. P. C. AZIAGBA AND E. H. UZOEZI. (Received 10, September 2009; Revision Accepted 8, February 2010). ABSTRACT. This survey was undertaken to portray the level of library involvement ...

Undergraduate Students Do Not Understand Some Library Jargon Typically Used in Library Instruction. A review of: Hutcherson, Norman B. “Library Jargon: Student Recognition of Terms and Concepts Commonly Used by Librarians in the Classroom.” College and Research Libraries 65.4 (July 2004: 349‐54.

Directory of Open Access Journals (Sweden)

Lorie A. Kloda

2006-03-01

Full Text Available Objective - To determine students' level of recognition for 28 commonly used terms in library instruction. Design - Survey, multiple-choice questionnaire. Setting - Large state university library in the United States (this is assumed from the author's current affiliation. Subjects - 300 first- and second-year university students enrolled in a library skills course between September 2000 and June 2003. Methods - Two 15-question multiple choice questionnaires were created to verify students' understanding of 28 terms commonly used in library instruction, or "library jargon". Each questionnaire included 12 unique terms and, in order to ensure consistency between questionnare results, three common terms. For each question, a definition was provided and four terms, including the correct one, were offered as possible answers. Four variants of each survey were developed with varied question and answer order. Students who completed a seven-week library skills lab received one of the two questionnares. Lab instructors explained the objective of the survey and the students completed them in 10 to 15 minutes during class time. Of the 300 students enrolled in the lab between September 2000 and June 2003, 297 returned completed questionnaires. The researcher used Microsoft Excel to calculate descriptive statistics, includeing then mean, median, and standard deviation for individual questionnaires as well as combined results. No demographic data were collected. Main results - The mean score for both questionnaires was 62.31% (n= 297. That is, on average, students answered 9.35 out of 15 questions correctly, with a standard deviation of +-4.12. Students were able to recognize library-related terms to varying degrees. Terms identified correctly most often included: plagarism (100%, reference servives (94.60%, research (94.00%, copyright (91.58%, and table of contents (90.50%. Terms identified correctly the least often included: Boolean logic (8

E-library Implementation in Library University of Riau

Science.gov (United States)

Yuhelmi; Rismayeti

2017-12-01

This research aims to see how the e-book implementation in Library University of Riau and the obstacle in its implementation. In the Globalization era, digital libraries should be developed or else it will decrease the readers’ interest, with the recent advanced technology, digital libraries are one of the learning tools that can be used to finding an information through the internet access, hence digital libraries or commonly known as E-Library is really helping the students and academic community in finding information. The methods that used in this research is Observation, Interview, and Literature Study. The respondents in this research are the staff who involved in the process of digitization in Library University of Riau. The result of this research shows that implementation of e-library in Library University of Riau is already filled the user needs for now, although there is obstacle faced just like technical problems for example the internet connection speed and the technical problem to convert the format from Microsoft Word .doc to Adobe.pdf

A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells

Directory of Open Access Journals (Sweden)

Andreas Kurtz

2018-01-01

Full Text Available Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg. To avoid ambiguities in PSC-line referencing, we strongly urge publishers to demand registration and use of the standard name when publishing research based on hPSC lines.

A reliable parameter to standardize the scoring of stem cell spheres.

Directory of Open Access Journals (Sweden)

Xiaochen Zhou

Full Text Available Sphere formation assay is widely used in selection and enrichment of normal stem cells or cancer stem cells (CSCs, also known as tumor initiating cells (TICs, based on their ability to grow in serum-free suspension culture for clonal proliferation. However, there is no standardized parameter to accurately score the spheres, which should be reflected by both the number and size of the spheres. Here we define a novel parameter, designated as Standardized Sphere Score (SSS, which is expressed by the total volume of selected spheres divided by the number of cells initially plated. SSS was validated in quantification of both tumor spheres from cancer cell lines and embryonic bodies (EB from mouse embryonic stem cells with high sensitivity and reproducibility.

Marketing library and information services in academic libraries in ...

African Journals Online (AJOL)

Marketing library and information services in academic libraries in Niger State, Nigeria. ... This study was designed to investigate the marketing of library services in academic libraries in Niger state, ... EMAIL FULL TEXT EMAIL FULL TEXT

Safety standards, legislation and codes of practice for fuel cell manufacture and operation

Energy Technology Data Exchange (ETDEWEB)

Wilcox, C.P.

1999-07-01

This report examines safety standards, legislation and codes of practice for fuel cell manufacture and operation in the UK, Europe and internationally. Management of health and safety in the UK is discussed, and the characteristics of phosphoric acid (PAFC), proton exchange membrane (PEM), molten carbonate (MCFC), solid oxide (SOFC) fuel cells are described. Fuel cell power plant standards and manufacture in the UK, design and operational considerations, end of life disposal, automotive fuel cell system, and fuelling and vehicular concerns are explored, and standards, legislation and codes of practice are explained in the appendix.

Personal Virtual Libraries

Science.gov (United States)

Pappas, Marjorie L.

2004-01-01

Virtual libraries are becoming more and more common. Most states have a virtual library. A growing number of public libraries have a virtual presence on the Web. Virtual libraries are a growing addition to school library media collections. The next logical step would be personal virtual libraries. A personal virtual library (PVL) is a collection…

Establishing a PWR burn-up library

International Nuclear Information System (INIS)

Lutz, D.C.

1981-01-01

Starting out from data file ENDF/B IV /1/, a cross-section library has been established for the calculation of operating conditions in pressurized water reactors of the type used in BIBLIS B. The library includes macroscopic, homogenized 2-group cross-sections for all types of fuel elements used in this reactor, including those equipped with boron glass rods. For their calculation the previous irradiation of the fuel has been taken into consideration by approximation. Information on fuel consumption from cell burn-up calculations has been stored in a separate data file. It was designed as a base for the determination of cross sections to be used in the calculation of the incident ''main-steam pipe fracture''. For this library the description of cross sections as a function of the moderator status chose the water densities at 300 0 C/155 bar, 190 0 C/140 bar and 100 0 C/100 bar as fixed values. The burn-up library has been tested by a three-dimensional calculation for the 1sup(st) cycle of the BIBLIS B-reactor using program QUABOX /2/. This showed variances with the anticipated course concerning critically, which can be explained almost quantitatively by known deficiencies of the ENDF/b-IV library. (orig.) [de

An in silico MS/MS library for automatic annotation of novel FAHFA lipids.

Science.gov (United States)

Ma, Yan; Kind, Tobias; Vaniya, Arpana; Gennity, Ingrid; Fahrmann, Johannes F; Fiehn, Oliver

2015-01-01

A new lipid class named 'fatty acid esters of hydroxyl fatty acids' (FAHFA) was recently discovered in mammalian adipose tissue and in blood plasma and some FAHFAs were found to be associated with type 2 diabetes. To facilitate the automatic annotation of FAHFAs in biological specimens, a tandem mass spectra (MS/MS) library is needed. Due to the limitation of the commercial available standard compounds, we proposed building an in silico MS/MS library to extend the coverage of molecules. We developed a computer-generated library with 3267 tandem mass spectra (MS/MS) for 1089 FAHFA species. FAHFA spectra were generated based on authentic standards with negative mode electrospray ionization and 10, 20, and 40 V collision induced dissociation at 4 spectra/s as used in in ultra-high performance liquid chromatography-QTOF mass spectrometry studies. However, positional information of the hydroxyl group is only obtained either at lower QTOF spectra acquisition rates of 1 spectrum/s or at the MS(3) level in ion trap instruments. Therefore, an additional set of 4290 fragment-rich MS/MS spectra was created to enable distinguishing positional FAHFA isomers. The library was generated based on ion fragmentations and ion intensities of FAHFA external reference standards, developing a heuristic model for fragmentation rules and extending these rules to large swaths of computer-generated structures of FAHFAs with varying chain lengths, degrees of unsaturation and hydroxyl group positions. Subsequently, we validated the new in silico library by discovering several new FAHFA species in egg yolk, showing that this library enables high-throughput screening of FAHFA lipids in various biological matrices. The developed library and templates are freely available for commercial or noncommercial use at http://fiehnlab.ucdavis.edu/staff/yanma/fahfa-lipid-library. This in silico MS/MS library allows users to annotate FAHFAs from accurate mass tandem mass spectra in an easy and fast manner

America's Star Libraries

Science.gov (United States)

Lyons, Ray; Lance, Keith Curry

2009-01-01

"Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

Internal Control Systems in the Library Environment.

Science.gov (United States)

Begg, Robert T.

1985-01-01

Examines system for safeguarding assets and guaranteeing reliability of library's financial records within context of management functions that comprise accounting controls: planning by budget or other standard of comparison; operation of effective accounting and record-keeping system; personnel management practices. Cash controls as example of…

New Standard Evaluated Neutron Cross Section Libraries for the GEANT4 Code and First Verification

CERN Document Server

Mendoza, Emilio; Koi, Tatsumi; Guerrero, Carlos

2014-01-01

The Monte Carlo simulation of the interaction of neutrons with matter relies on evaluated nuclear data libraries and models. The evaluated libraries are compilations of measured physical parameters (such as cross sections) combined with predictions of nuclear model calculations which have been adjusted to reproduce the experimental data. The results obtained from the simulations depend largely on the accuracy of the underlying nuclear data used, and thus it is important to have access to the nuclear data libraries available, either of general use or compiled for specific applications, and to perform exhaustive validations which cover the wide scope of application of the simulation code. In this paper we describe the work performed in order to extend the capabilities of the GEANT4 toolkit for the simulation of the interaction of neutrons with matter at neutron energies up to 20 MeV and a first verification of the results obtained. Such a work is of relevance for applications as diverse as the simulation of a n...

A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells.

Science.gov (United States)

Kurtz, Andreas; Seltmann, Stefanie; Bairoch, Amos; Bittner, Marie-Sophie; Bruce, Kevin; Capes-Davis, Amanda; Clarke, Laura; Crook, Jeremy M; Daheron, Laurence; Dewender, Johannes; Faulconbridge, Adam; Fujibuchi, Wataru; Gutteridge, Alexander; Hei, Derek J; Kim, Yong-Ou; Kim, Jung-Hyun; Kokocinski, Anja Kolb-; Lekschas, Fritz; Lomax, Geoffrey P; Loring, Jeanne F; Ludwig, Tenneille; Mah, Nancy; Matsui, Tohru; Müller, Robert; Parkinson, Helen; Sheldon, Michael; Smith, Kelly; Stachelscheid, Harald; Stacey, Glyn; Streeter, Ian; Veiga, Anna; Xu, Ren-He

2018-01-09

Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC) lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg). To avoid ambiguities in PSC-line referencing, we strongly urge publishers to demand registration and use of the standard name when publishing research based on hPSC lines. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Portable reflection for C++ with the Mirror library

Directory of Open Access Journals (Sweden)

Matus Chochlik

2012-06-01

Full Text Available Reflection and reflective programming can be used for a wide range of tasks such as implementationof serialization-like operations, remote procedure calls, scripting, automated GUIgeneration,implementation of several software design patterns, etc. C++ as one of the mostprevalent programming languages however, for various reasons, lacks a standardized reflectionfacility. In this paper we present Mirror - a portable library adding reflection to C++ with acommand-line utility automating its usage. This library supports functional style static compiletimereflection and metaprogramming and also provides two different object-oriented run-timepolymorphic layers for dynamic reflection.

Parallelization of mathematical library for generalized eigenvalue problem for real band matrices

International Nuclear Information System (INIS)

Tanaka, Yasuhisa.

1997-05-01

This research has focused on a parallelization of the mathematical library for a generalized eigenvalue problem for real band matrices on IBM SP and Hitachi SR2201. The origin of the library is LASO (Lanczos Algorithm with Selective Orthogonalization), which was developed on the basis of Block Lanczos method for standard eigenvalue problem for real band matrices at Texas University. We adopted D.O.F. (Degree Of Freedom) decomposition method for a parallelization of this library, and evaluated its parallel performance. (author)

More library mashups exploring new ways to deliver library data

CERN Document Server

2015-01-01

Nicole Engard follows up her ground-breaking 2009 book Library Mashups with a fresh collection of mashup projects that virtually any library can emulate, customize, and build upon. In More Library Mashups, Engard and 24 creative library professionals describe how they are mashing up free and inexpensive digital tools and techniques to improve library services and meet everyday (and unexpected) challenges. Examples from libraries of all types are designed to help even non-programmers share and add value to digital content, update and enhance library websites and collections, mashup catalog data, connect to the library's automation system, and use emerging tools like Serendip-o-matic, Umlaut, and Libki to engage users, staff, and the community.

National Software Reference Library (NSRL)

Science.gov (United States)

National Software Reference Library (NSRL) (PC database for purchase)   A collaboration of the National Institute of Standards and Technology (NIST), the National Institute of Justice (NIJ), the Federal Bureau of Investigation (FBI), the Defense Computer Forensics Laboratory (DCFL),the U.S. Customs Service, software vendors, and state and local law enforement organizations, the NSRL is a tool to assist in fighting crime involving computers.

Building Component Library: An Online Repository to Facilitate Building Energy Model Creation; Preprint

Energy Technology Data Exchange (ETDEWEB)

Fleming, K.; Long, N.; Swindler, A.

2012-05-01

This paper describes the Building Component Library (BCL), the U.S. Department of Energy's (DOE) online repository of building components that can be directly used to create energy models. This comprehensive, searchable library consists of components and measures as well as the metadata which describes them. The library is also designed to allow contributors to easily add new components, providing a continuously growing, standardized list of components for users to draw upon.

Creating transient cell membrane pores using a standard inkjet printer.

Science.gov (United States)

Owczarczak, Alexander B; Shuford, Stephen O; Wood, Scott T; Deitch, Sandra; Dean, Delphine

2012-03-16

Bioprinting has a wide range of applications and significance, including tissue engineering, direct cell application therapies, and biosensor microfabrication. Recently, thermal inkjet printing has also been used for gene transfection. The thermal inkjet printing process was shown to temporarily disrupt the cell membranes without affecting cell viability. The transient pores in the membrane can be used to introduce molecules, which would otherwise be too large to pass through the membrane, into the cell cytoplasm. The application being demonstrated here is the use of thermal inkjet printing for the incorporation of fluorescently labeled g-actin monomers into cells. The advantage of using thermal ink-jet printing to inject molecules into cells is that the technique is relatively benign to cells. Cell viability after printing has been shown to be similar to standard cell plating methods. In addition, inkjet printing can process thousands of cells in minutes, which is much faster than manual microinjection. The pores created by printing have been shown to close within about two hours. However, there is a limit to the size of the pore created (~10 nm) with this printing technique, which limits the technique to injecting cells with small proteins and/or particles. A standard HP DeskJet 500 printer was modified to allow for cell printing. The cover of the printer was removed and the paper feed mechanism was bypassed using a mechanical lever. A stage was created to allow for placement of microscope slides and coverslips directly under the print head. Ink cartridges were opened, the ink was removed and they were cleaned prior to use with cells. The printing pattern was created using standard drawing software, which then controlled the printer through a simple print command. 3T3 fibroblasts were grown to confluence, trypsinized, and then resuspended into phosphate buffered saline with soluble fluorescently labeled g-actin monomers. The cell suspension was pipetted into the

Library Science Education: A New Role for Academic Libraries

Science.gov (United States)

Wesley, Threasa L.

2018-01-01

Many individuals working in library and information organizations do not hold a master of library science (MLS) degree or other specialized library science credential. Recognizing that this professional gap could be addressed by diversified educational opportunities, the W. Frank Steely Library at Northern Kentucky University in Highland Heights…

Library of monoclonal antibodies against brush border membrane epithelial antigens

International Nuclear Information System (INIS)

Behar, M.; Katz, A.; Silverman, M.

1986-01-01

A purified fraction of proximal tubule brush border membranes (BBM) was prepared from dog kidney and used to immunize mice. The standard technique of hybridoma production was followed as described by Kohler and Milstein. Production of antibodies was detected by indirect immunofluorescence on dog kidney slices and by immunodot against the purified fraction on nitrocellulose. Five hybrids exhibited anti BBM activity. These were cloned twice and yielded stable cell lines producing IgG type monoclonal antibodies against BBM. They were designated A 1 , C 7 , D 3 , D 7 and H 4 . As a family these five monoclonals have broad tissue specificity, i.e. positive staining of the surface mucosa of intestinal kidney proximal tubules. D 3 exhibits even broader specificity for epithelium reacting with bile canaliculi and choroid plexus. The authors have verified that at least 4/5 antibodies are directed against BBM protein as revealed by immunoprecipitation of solubilized BBM and detected by Coomassie blue staining or autoradiography of lactoperoxidase labelled BBM. Most interestingly all antibodies bind to the surface of LL CPK 1 cells, a continuous pig kidney cell line of undefined origin but exhibiting many characteristics of proximal tubule cells. The library of monoclonal antibodies obtained provide important probes with which to study membrane biogenesis and polarization in epithelial cells

Introducing Information Literacy Competency Standards for Nursing.

Science.gov (United States)

Phelps, Sue F; Hyde, Loree; Planchon Wolf, Julie

2015-01-01

The Association for College and Research Libraries published the Information Literacy Competency Standards for Nursing (ILCSN) in January 2014, written by a task force of the Health Sciences Interest Group of the American Library Association. The ILCSN describes skills ranging from basic to advanced information research competencies for students enrolled in nursing programs at all levels and for professional nurses. This article guides administrators and faculty in use of the standards to design programs and coursework in information skills to support evidence-based practice.

General Maister's Library in the University of Maribor Library: Gaining and Preservation of the General Maister's Private Library in the University of Maribor Library

Directory of Open Access Journals (Sweden)

Vlasta Stavbar

2015-12-01

Full Text Available Rudolf Maister’s book legacy, which is kept in the University of Maribor Library, is the complete legacy of the Maister’s private book collection– the “maistirana”. The Maister’s Library is in the University of Maribor Library possession since 1998, when General Maister’s heirs and the Library signed the deed of donation. 5.945 units of library materials present a special collection, which is divided from the regular library holdings and is kept in a specially designed room. General Maister’s Library is an exception in the University of Maribor Library, since the general practice of libraries is not an exclusive maintenance of the provenience principle and of the original organisation. Because the Maister’s Library consists of materials that are important when researching the Slovene literary and cultural past, it only seems reasonably to strive for the authentic organisation and preserving the library as one integral whole.In order to understand the meaning and the importance of this special library collection for the Slovene cultural heritage, we have to highlight Rudolf Maister as a passionate book lover and as the owner of one of the greatest and the most beautiful private libraries in Slovenia. General Maister started collecting books and organising his collection back in 1912 in Ljubljana; the collection was rearranged thoroughly during the time he was in Maribor; it survived the moves during World War II and after it and it finally found its place in the General Maister’s Library under the patronage of the University of Maribor Library. The rearranging of the shelving system and sorting of the materials patterned after the authentic shelving system in the General’s Maribor apartment took place in 2013. Until then the books were not arranged according to the authentic shelving system. The estimated shelving system reconstruction has reconstructed Maister’s shelving system as authentically as possible, for it is not

Assessing Customer Satisfaction at the NIST Research Library: Essential Tool for Future Planning

Science.gov (United States)

Liu, Rosa; Allmang, Nancy

2008-01-01

This article describes a campus-wide customer satisfaction survey undertaken by the National Institute of Standards and Technology (NIST) Research Library in 2007. The methodology, survey instrument, data analysis, results, and actions taken in response to the survey are described. The outcome and recommendations will guide the library both…

Constructing and Reading Visual Information: Visual Literacy for Library and Information Science Education

Science.gov (United States)

Ma, Yan

2015-01-01

This article examines visual literacy education and research for library and information science profession to educate the information professionals who will be able to execute and implement the ACRL (Association of College and Research Libraries) Visual Literacy Competency Standards successfully. It is a continuing call for inclusion of visual…

Why We Should Establish a National System of Standards.

Science.gov (United States)

Hennen, Thomas J., Jr.

2000-01-01

Explains the need to establish a national system of standards for public libraries. Discusses local standards, state standards, and international standards, and suggests adopting a tiered approach including three levels: minimum standards; target standards; and benchmarking standards, as found in total quality management. (LRW)

Library usage patterns in the electronic information environment. Electronic journals, Use studies, Libraries, Medical libraries

Directory of Open Access Journals (Sweden)

B. Franklin

2004-01-01

Full Text Available This paper examines the methodology and results from Web-based surveys of more than 15,000 networked electronic services users in the United States between July 1998 and June 2003 at four academic health sciences libraries and two large main campus libraries serving a variety of disciplines. A statistically valid methodology for administering simultaneous Web-based and print-based surveys using the random moments sampling technique is discussed and implemented. Results from the Web-based surveys showed that at the four academic health sciences libraries, there were approximately four remote networked electronic services users for each in-house user. This ratio was even higher for faculty, staff, and research fellows at the academic health sciences libraries, where more than five remote users for each in-house user were recorded. At the two main libraries, there were approximately 1.3 remote users for each in-house user of electronic information. Sponsored research (grant funded research accounted for approximately 32% of the networked electronic services activity at the health sciences libraries and 16% at the main campus libraries. Sponsored researchers at the health sciences libraries appeared to use networked electronic services most intensively from on-campus, but not from in the library. The purpose of use for networked electronic resources by patrons within the library is different from the purpose of use of those resources by patrons using the resources remotely. The implications of these results on how librarians reach decisions about networked electronic resources and services are discussed.

HPDB-Haskell library for processing atomic biomolecular structures in Protein Data Bank format.

Science.gov (United States)

Gajda, Michał Jan

2013-11-23

Protein DataBank file format is used for the majority of biomolecular data available today. Haskell is a lazy functional language that enjoys a high-level class-based type system, a growing collection of useful libraries and a reputation for efficiency. I present a fast library for processing biomolecular data in the Protein Data Bank format. I present benchmarks indicating that this library is faster than other frequently used Protein Data Bank parsing programs. The proposed library also features a convenient iterator mechanism, and a simple API modeled after BioPython. I set a new standard for convenience and efficiency of Protein Data Bank processing in a Haskell library, and release it to open source.

Library Subject Guides: A Case Study of Evidence-Informed Library Development

Science.gov (United States)

Wakeham, Maurice; Roberts, Angharad; Shelley, Jane; Wells, Paul

2012-01-01

This paper describes the process whereby a university library investigated the value of its subject guides to its users. A literature review and surveys of library staff, library users and other libraries were carried out. Existing library subject guides and those of other higher education libraries were evaluated. The project team reported…

Standards-based teaching and educational digital libraries as innovations: Undergraduate science faculty in the adoption process

Science.gov (United States)

Ridgway, Judith Sulkes

This study describes undergraduate science faculty in terms of their feelings of preparedness for and their use of standards-based teaching methods, their stages of concern related to Educational Digital Libraries (EDLs), and their adoption and diffusion of both innovations. These innovations may have a synergistic relationship that may result in enhanced adoption of both. The investigation began with a series of group meetings with life science, chemistry, physics, and geology faculty from a 2-year and a 4-year institution. Faculty were introduced to dimensions of standards-based teaching and examples of EDLs. Faculty completed the Demographics and Experience Questionnaire, the Standards-Based Teaching Instrument, and the Stages of Concern Questionnaire (SoCQ). Semi-structured interviews containing literature-based questions were conducted with one faculty member from each discipline from the 2-year and 4-year institutions. Document analyses were performed on mission/goal web-based statements for the institutions and their science departments. Triangulated data were used to construct individual faculty case studies based on four facets: background, standards-based teaching profile, EDLs profile, and rate of innovation diffusion. The individual case studies were used to perform cross-case analyses by type of institution, discipline, and locus of control. Individual case studies and cross-case analyses suggest the following conclusions: (a) faculty felt prepared to use and frequently used textbooks as a reference, (b) feelings of preparedness and frequency of use of standards-based teaching categories may be related to discipline, (c) all faculty had relatively high awareness and informational EDL concerns, and (d) faculty central to the locus of control were more likely to use methods to develop student conceptual understanding, use inquiry methods, and be agents of change. A grounded theoretical model connects study results with literature related to educational

Library subject guides: A case study of evidence-informed library development

OpenAIRE

Wakeham, Maurice; Roberts, Angharad; Shelley, Jane; Wells, Paul

2012-01-01

This paper describes the process whereby a university library investigated the value of its subject guides to its users. A literature review and surveys of library staff, library users and other libraries were carried out. Existing library subject guides and those of other higher education libraries were evaluated. The project team reported regularly to the wider library team throughout the year long investigation and made recommendations. The project served to develop the professional skills...

Toward a digital library strategy for a National Information Infrastructure

Science.gov (United States)

Coyne, Robert A.; Hulen, Harry

1993-01-01

Bills currently before the House and Senate would give support to the development of a National Information Infrastructure, in which digital libraries and storage systems would be an important part. A simple model is offered to show the relationship of storage systems, software, and standards to the overall information infrastructure. Some elements of a national strategy for digital libraries are proposed, based on the mission of the nonprofit National Storage System Foundation.

Issues and challenges facing school libraries in selected primary ...

African Journals Online (AJOL)

Hennie

and 79% of schools had no library at all (Department of Basic Education (DBE) ... particularly in literacy and mathematics, as compared to national curriculum standards and international ... range of new and ever-changing technologies.

Targeting mammalian organelles with internalizing phage (iPhage) libraries

Science.gov (United States)

Rangel, Roberto; Dobroff, Andrey S.; Guzman-Rojas, Liliana; Salmeron, Carolina C.; Gelovani, Juri G.; Sidman, Richard L.; Pasqualini, Renata; Arap, Wadih

2015-01-01

Techniques largely used for protein interaction studies and discovery of intracellular receptors, such as affinity capture complex purification and yeast two-hybrid, may produce inaccurate datasets due to protein insolubility, transient or weak protein interactions, or irrelevant intracellular context. A versatile tool to overcome these limitations as well as to potentially create vaccines and engineer peptides and antibodies as targeted diagnostic and therapeutic agents, is the phage display technique. We have recently developed a new technology for screening internalizing phage (iPhage) vectors and libraries utilizing a ligand/receptor-independent mechanism to penetrate eukaryotic cells. iPhage particles provide a unique discovery platform for combinatorial intracellular targeting of organelle ligands along with their corresponding receptors and to fingerprint functional protein domains in living cells. Here we explain the design, cloning, construction, and production of iPhage-based vectors and libraries, along with basic ligand-receptor identification and validation methodologies for organelle receptors. An iPhage library screening can be performed in ~8 weeks. PMID:24030441

Generation and testing of the shielding data library EURLIB for fission and fusion technology

International Nuclear Information System (INIS)

Caglioti, E.; Hehn, G.; Herrnberger, V.; Mattes, M.; Nicks, R.; Penkuhn, H.

1977-01-01

For the common field of core physics and shielding, the CSEWG group structure of 239 fast neutron groups had been proposed, of which the 100 neutron groups of the EURLIB Library is a sub-set for shielding. This standard group Library EURLIB had been initiated by the NEA-specialist group on shielding benchmarks in 1974. The wide acceptance of the Library for interpretation of benchmarks in the NEA program represents an important step forward in the standardization of group data which is the basic requirement for a useful collaboration. On the other side the interpretation of a series of different benchmark experiments with the EURLIB Library provides the best check of the cross section data for neutron and gamma-rays showing the needs for further improvements. The paper describes the joint work of IKE, Stuttgart and EURATOM, Ispra in generating multigroup libraries for neutron and gamma-rays. Special effort has been devoted to improve the flux weighting for both types of radiation and proper treatment of thermal neutrons. The coupled multigroup Library of 100 neutron and 20 gamma groups is collapsed into few group structures for typical designs of LWR, LMFBR, gas cooled and thermonuclear reactors. The work for optimal few group representation is done in cooperation with EIR, Wurenlingen. The testing of the EURLIB Library is a common effort of several institutions participating in the NEA shielding benchmark program

Multi-line split DNA synthesis: a novel combinatorial method to make high quality peptide libraries

Directory of Open Access Journals (Sweden)

Ueno Shingo

2004-09-01

Full Text Available Abstract Background We developed a method to make a various high quality random peptide libraries for evolutionary protein engineering based on a combinatorial DNA synthesis. Results A split synthesis in codon units was performed with mixtures of bases optimally designed by using a Genetic Algorithm program. It required only standard DNA synthetic reagents and standard DNA synthesizers in three lines. This multi-line split DNA synthesis (MLSDS is simply realized by adding a mix-and-split process to normal DNA synthesis protocol. Superiority of MLSDS method over other methods was shown. We demonstrated the synthesis of oligonucleotide libraries with 1016 diversity, and the construction of a library with random sequence coding 120 amino acids containing few stop codons. Conclusions Owing to the flexibility of the MLSDS method, it will be able to design various "rational" libraries by using bioinformatics databases.

The history and library statistics of JAEA library activities

Energy Technology Data Exchange (ETDEWEB)

Itabashi, Keizo [Japan Atomic Energy Agency, Intellectual Resources Dept., Tokai, Ibaraki (Japan)

2012-03-15

The history and library statistics of the Japan Atomic Energy Agency library activity were summarized. Former Japan Atomic Energy Research Institute and the former Japan Nuclear Cycle Development Institute merged in October, 2005, and Japan Atomic Energy Agency is established. Properly speaking, the library statistics of old two corporations should have been summarized, but statistics of the Japan Nuclear Cycle Development Institute is not yet obtained. Then, although it is stated as the Japan Atomic Energy Agency library, it limits to the description about the old Japan Atomic Energy Research Institute library before 2004. (author)

The history and library statistics of JAEA library activities

International Nuclear Information System (INIS)

Itabashi, Keizo

2012-03-01

The history and library statistics of the Japan Atomic Energy Agency library activity were summarized. Former Japan Atomic Energy Research Institute and the former Japan Nuclear Cycle Development Institute merged in October, 2005, and Japan Atomic Energy Agency is established. Properly speaking, the library statistics of old two corporations should have been summarized, but statistics of the Japan Nuclear Cycle Development Institute is not yet obtained. Then, although it is stated as the Japan Atomic Energy Agency library, it limits to the description about the old Japan Atomic Energy Research Institute library before 2004. (author)

The Leadership Dimension in Information and Communication Technology Adoption in African Libraries

Directory of Open Access Journals (Sweden)

Adetoun A. Oyelude

2014-02-01

Full Text Available The article focuses on leadership challenges in adaptation to Information and Communication Technologies (ICTs in African libraries. It identifies and discusses the need for adequate leadership styles and behavior in the bid to adapt effectively to new technologies. Online survey, observation arising from personal professional practice experience, personal communication, and interview methods were used to gather data for the study. Older library professionals, many of whom are still very visible across the leadership strata of libraries, were found to exhibit diverse attitude to the adaptation to ICTs deployment and use in their libraries. Some library leaders and older generation professionals were discovered to react somewhat negatively to changes in technology used in their libraries, preventing the younger professionals from performing to full capacity, and generally showing nonchalance to new technologies. Proper training and retraining, mentoring, and harnessing the synergy of ideas, with respectful communication from new generation library professionals, was found to be desirable. Change management workshops and implementation of standard ethics of the profession are recommended, while emphasis is put on the need for library professionals to overcome their technophobia and take leadership in adapting to move the library and information profession forward.

A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies.

Science.gov (United States)

Qudsia, Sehar; Merugu, Siva B; Mangukiya, Hitesh B; Hema, Negi; Wu, Zhenghua; Li, Dawei

2018-04-30

Antibody display libraries have become a popular technique to screen monoclonal antibodies for therapeutic purposes. An important aspect of display technology is to generate an optimization library by changing antibody affinity to antigen through mutagenesis and screening the high affinity antibody. In this study, we report a novel lentivirus display based optimization library antibody in which Agtuzumab scFv is displayed on cell membrane of HEK-293T cells. To generate an optimization library, hotspot mutagenesis was performed to achieve diverse antibody library. Based on sequence analysis of randomly selected clones, library size was estimated approximately to be 1.6 × 10 6 . Lentivirus display vector was used to display scFv antibody on cell surface and flow cytometery was performed to check the antibody affinity to antigen. Membrane bound scFv antibodies were then converted to secreted antibody through cre/loxP recombination. One of the mutant clones, M8 showed higher affinity to antigen in flow cytometery analysis. Further characterization of cellular and secreted scFv through western blot showed that antibody affinity was increased by three fold after mutagenesis. This study shows successful construction of a novel antibody library and suggests that hotspot mutagenesis could prove a useful and rapid optimization tool to generate similar libraries with various degree of antigen affinity. Copyright © 2018 Elsevier Inc. All rights reserved.

Wikis in Libraries

Directory of Open Access Journals (Sweden)

Matthew Bejune

2007-09-01

Full Text Available Wikis have recently been adopted to support a variety of collaborative activities within libraries. This article and its companion wiki, LibraryWikis (http://librarywikis.pbwiki.com/, seek to document the phenomenon of wikis in libraries. This subject is considered within the framework of computer-supported cooperative work (CSCW. The author identified thirty-three library wikis and developed a classification schema with four categories: (1 collaboration among libraries (45.7 percent; (2 collaboration among library staff (31.4 percent; (3 collaboration among library staff and patrons (14.3 percent; and (4 collaboration among patrons (8.6 percent. Examples of library wikis are presented within the article, as is a discussion for why wikis are primarily utilized within categories I and II and not within categories III and IV. It is clear that wikis have great utility within libraries, and the author urges further application of wikis in libraries.

High content screening of defined chemical libraries using normal and glioma-derived neural stem cell lines.

Science.gov (United States)

Danovi, Davide; Folarin, Amos A; Baranowski, Bart; Pollard, Steven M

2012-01-01

Small molecules with potent biological effects on the fate of normal and cancer-derived stem cells represent both useful research tools and new drug leads for regenerative medicine and oncology. Long-term expansion of mouse and human neural stem cells is possible using adherent monolayer culture. These cultures represent a useful cellular resource to carry out image-based high content screening of small chemical libraries. Improvements in automated microscopy, desktop computational power, and freely available image processing tools, now means that such chemical screens are realistic to undertake in individual academic laboratories. Here we outline a cost effective and versatile time lapse imaging strategy suitable for chemical screening. Protocols are described for the handling and screening of human fetal Neural Stem (NS) cell lines and their malignant counterparts, Glioblastoma-derived neural stem cells (GNS). We focus on identification of cytostatic and cytotoxic "hits" and discuss future possibilities and challenges for extending this approach to assay lineage commitment and differentiation. Copyright © 2012 Elsevier Inc. All rights reserved.

Physical Principles of Development of the State Standard of Biological Cell Polarizability

Science.gov (United States)

Shuvalov, G. V.; Generalov, K. V.; Generalov, V. M.; Kruchinina, M. V.; Koptev, E. S.; Minin, O. V.; Minin, I. V.

2018-03-01

A new state standard of biological cell polarizability based on micron-size latex particles has been developed. As a standard material, it is suggested to use polystyrene. Values of the polarizability calculated for erythrocytes and values of the polarizability of micron-size spherical latex particles measured with measuring-computing complexes agree within the limits of satisfactory relative error. The Standard allows one the unit of polarizability measurements [m3] to be assigned to cells and erythrocytes for the needs of medicine.

USGS Spectral Library Version 7

Science.gov (United States)

Kokaly, Raymond F.; Clark, Roger N.; Swayze, Gregg A.; Livo, K. Eric; Hoefen, Todd M.; Pearson, Neil C.; Wise, Richard A.; Benzel, William M.; Lowers, Heather A.; Driscoll, Rhonda L.; Klein, Anna J.

2017-04-10

We have assembled a library of spectra measured with laboratory, field, and airborne spectrometers. The instruments used cover wavelengths from the ultraviolet to the far infrared (0.2 to 200 microns [μm]). Laboratory samples of specific minerals, plants, chemical compounds, and manmade materials were measured. In many cases, samples were purified, so that unique spectral features of a material can be related to its chemical structure. These spectro-chemical links are important for interpreting remotely sensed data collected in the field or from an aircraft or spacecraft. This library also contains physically constructed as well as mathematically computed mixtures. Four different spectrometer types were used to measure spectra in the library: (1) Beckman™ 5270 covering the spectral range 0.2 to 3 µm, (2) standard, high resolution (hi-res), and high-resolution Next Generation (hi-resNG) models of Analytical Spectral Devices (ASD) field portable spectrometers covering the range from 0.35 to 2.5 µm, (3) Nicolet™ Fourier Transform Infra-Red (FTIR) interferometer spectrometers covering the range from about 1.12 to 216 µm, and (4) the NASA Airborne Visible/Infra-Red Imaging Spectrometer AVIRIS, covering the range 0.37 to 2.5 µm. Measurements of rocks, soils, and natural mixtures of minerals were made in laboratory and field settings. Spectra of plant components and vegetation plots, comprising many plant types and species with varying backgrounds, are also in this library. Measurements by airborne spectrometers are included for forested vegetation plots, in which the trees are too tall for measurement by a field spectrometer. This report describes the instruments used, the organization of materials into chapters, metadata descriptions of spectra and samples, and possible artifacts in the spectral measurements. To facilitate greater application of the spectra, the library has also been convolved to selected spectrometer and imaging spectrometers sampling and

State Virtual Libraries

Science.gov (United States)

Pappas, Marjorie L.

2003-01-01

Virtual library? Electronic library? Digital library? Online information network? These all apply to the growing number of Web-based resource collections managed by consortiums of state library entities. Some, like "INFOhio" and "KYVL" ("Kentucky Virtual Library"), have been available for a few years, but others are just starting. Searching for…

The developments of international hydrogen and fuel cell technology standards and the response strategies in Taiwan

International Nuclear Information System (INIS)

Tso, C.

2009-01-01

The application of hydrogen and fuel cells has expanded as the technology in international markets has improved. Leading countries have focused on establishing hydrogen and fuel cell technology standards. Both the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC) continuously release new hydrogen and fuel cell related standards. Although the government of Taiwan is promoting the development of a hydrogen and fuel cell industry, it may delay the commercialized schedule if there are no hydrogen and fuel cell related standards and regulations in place. Standards and regulations must be established as quickly as possible in order to accelerate the progress of the hydrogen and fuel cell industry. This presentation reviewed the international progress in hydrogen and fuel cell development and explained Taiwan's response strategies regarding the adoption of hydrogen and fuel cell products in niche Taiwanese markets

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library

Directory of Open Access Journals (Sweden)

Eddy Edward M

2007-07-01

Full Text Available Abstract Background The primary regulator of spermatogenesis, a highly ordered and tightly regulated developmental process, is an intrinsic genetic program involving male germ cell-specific genes. Results We analyzed the mouse spermatocyte UniGene library containing 2155 gene-oriented transcript clusters. We predict that 11% of these genes are testis-specific and systematically identified 24 authentic genes specifically and abundantly expressed in the testis via in silico and in vitro approaches. Northern blot analysis disclosed various transcript characteristics, such as expression level, size and the presence of isoform. Expression analysis revealed developmentally regulated and stage-specific expression patterns in all of the genes. We further analyzed the genes at the protein and cellular levels. Transfection assays performed using GC-2 cells provided information on the cellular characteristics of the gene products. In addition, antibodies were generated against proteins encoded by some of the genes to facilitate their identification and characterization in spermatogenic cells and sperm. Our data suggest that a number of the gene products are implicated in transcriptional regulation, nuclear integrity, sperm structure and motility, and fertilization. In particular, we found for the first time that Mm.333010, predicted to contain a trypsin-like serine protease domain, is a sperm acrosomal protein. Conclusion We identify 24 authentic genes with spermatogenic cell-specific expression, and provide comprehensive information about the genes. Our findings establish a new basis for future investigation into molecular mechanisms underlying male reproduction.

LabVIEW Library to EPICS Channel Access

CERN Document Server

Liyu, Andrei; Thompson, Dave H

2005-01-01

The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based and will run Windows for its OS and LabVIEW as its programming language. Data acquisition hardware will be based on PCI cards. There will be about 300 rack-mounted computers. The Channel Access (CA) protocol of the Experimental Physics and Industrial Control System (EPICS) is the SNS control system communication standard. This paper describes the approaches, implementation, and features of LabVIEW library to CA for Windows, Linux, and Mac OS X. We also discuss how the library implements the asynchronous CA monitor routine using LabVIEW's occurrence mechanism instead of a callback function (which is not available in LabVIEW). The library is used to acquire accelerator data and applications have been ...

A renaissance in library metadata? The importance of community collaboration in a digital world

Directory of Open Access Journals (Sweden)

Sarah Bull

2016-07-01

Full Text Available This article summarizes a presentation given by Sarah Bull as part of the Association of Learned and Professional Society Publishers (ALPSP seminar ‘Setting the Standard’ in November 2015. Representing the library community at the wide-ranging seminar, Sarah was tasked with making the topic of library metadata an engaging and informative one for a largely publisher audience. With help from co-author Amanda Quimby, this article is an attempt to achieve the same aim! It covers the importance of library metadata and standards in the supply chain and also reflects on the role of the community in successful standards development and maintenance. Special emphasis is given to the importance of quality in e-book metadata and the need for publisher and library collaboration to improve discovery, usage and the student experience. The article details the University of Birmingham experience of e-book metadata from a workflow perspective to highlight the complex integration issues which remain between content procurement and discovery.

A MuDDy Experience-ML Bindings to a BDD Library

DEFF Research Database (Denmark)

Larsen, Ken Friis

2009-01-01

. This combination of an ML interface to a high-performance C library is surprisingly fruitful. ML allows you to quickly experiment with high-level symbolic algorithms before handing over the grunt work to the C library. I show how, with a relatively little effort, you can make a domain specific language...... for concurrent finite state-machines embedded in Standard ML and then write various custom model-checking algorithms for this domain specific embedded language (DSEL)....

Reactive Programming in Standard ML

OpenAIRE

Pucella, Riccardo

2004-01-01

Reactive systems are systems that maintain an ongoing interaction with their environment, activated by receiving input events from the environment and producing output events in response. Modern programming languages designed to program such systems use a paradigm based on the notions of instants and activations. We describe a library for Standard ML that provides basic primitives for programming reactive systems. The library is a low-level system upon which more sophisticated reactive behavi...

Library Systems: FY 2013 Public Libraries Survey (Administrative Entity)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2013 data...

Library Systems: FY 2012 Public Libraries Survey (Administrative Entity)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2012 data...

Validation of evaluated neutron standard cross sections

International Nuclear Information System (INIS)

Badikov, S.; Golashvili, T.

2008-01-01

Some steps of the validation and verification of the new version of the evaluated neutron standard cross sections were carried out. In particular: -) the evaluated covariance data was checked for physical consistency, -) energy-dependent evaluated cross-sections were tested in most important neutron benchmark field - 252 Cf spontaneous fission neutron field, -) a procedure of folding differential standard neutron data in group representation for preparation of specialized libraries of the neutron standards was verified. The results of the validation and verification of the neutron standards can be summarized as follows: a) the covariance data of the evaluated neutron standards is physically consistent since all the covariance matrices of the evaluated cross sections are positive definite, b) the 252 Cf spectrum averaged standard cross-sections are in agreement with the evaluated integral data (except for 197 Au(n,γ) reaction), c) a procedure of folding differential standard neutron data in group representation was tested, as a result a specialized library of neutron standards in the ABBN 28-group structure was prepared for use in reactor applications. (authors)

An anti-tumor protein produced by Trichinella spiralis and identified by screening a T7 phage display library, induces apoptosis in human hepatoma H7402 cells

Science.gov (United States)

Trichinella spiralis infection confers effective resistance to tumor cell expansion. In this study, a T7 phage cDNA display library was constructed to express genes encoded by T. spiralis. Organic phase multi-cell screening was used to sort through candidate proteins in a transfected human chronic m...

School Libraries Play an Active, Transformational Role in Student Learning and Achievement. A review of: Todd, Ross J. “Student Learning Through Ohio School Libraries: A Summary of the Ohio Research Study.” Ohio Educational Library Media Association 15 Dec. 2003. Ohio Educational Library Media Association (OELMA, 2004. 15 Nov. 2006 .

Directory of Open Access Journals (Sweden)

Gayle Bogel

2006-12-01

Full Text Available Objective – This study explored links between school libraries and student learning outcomes that were defined in a multidimensional context, using data provided by the students themselves. The researchers examined learning outcomes that reached beyond the existing correlations of school library services and standardized test scores. Insight was provided into the interactions between students and school libraries that affect student learning. An overarching goal of the study was to establish ongoing dialogue to focus on evidence based practices that may lead to continuous improvement in school library services and to provide the basis for further research.Design – Web based survey.Subjects – Participants were 13,123 students in grades 3‐12 and 879 faculty at 39 schools across the state.Setting – Ohio Public school libraries.Methods – Thirty‐nine effective school libraries, staffed by credentialed school librarians, were chosen through a judgment sampling process, using criteria based on Ohio Guidelines for Effective School Library Media Programs. The guidelines are aligned to academic content standards, assessments, resources, and professional development. Two web based surveys were used to collect quantitative and qualitative data from students and faculty: 1. The Impacts on Learning Survey, composed of Likert scale responses to 48 statements and an open‐ended critical incident question for students. 2. The Perceptions of Learning Impacts Survey was a similar survey for faculty. Survey questions were based on Dervin’s theory of information seeking that advances the idea of ‘helps’ as the constructive process of bridging gaps in information use that lead to new knowledge or making sense (sense‐making in relation to a perceived information need (Todd and Kuhlthau. The term ‘helps’ includes both inputs (help that the school library provides in engaging students in learning and outputs (learning outcomes of academic

Monte Carlo simulations of the pulsed thermal neutron flux in two-region hydrogenous systems (using standard MCNP data libraries)

International Nuclear Information System (INIS)

Wiacek, U.; Krynicka, E.

2005-02-01

Monte Carlo simulations of the pulsed neutron experiment in two- region systems (two concentric spheres and two coaxial finite cylinders) are presented. The MCNP code is used. Aqueous solutions of H 3 BO 3 or KCl are used in the inner region. The outer region is the moderator of Plexiglas. Standard data libraries of the thermal neutron scattering cross-sections of hydrogen in hydrogenous substances are used. The time-dependent thermal neutron transport is simulated when the inner region has a constant size and the external size of the surrounding outer region is variable. The time decay constant of the thermal neutron flux in the system is found in each simulation. The results of the simulations are compared with results of real pulsed neutron experiments on the corresponding systems. (author)

Library Computing

Science.gov (United States)

Library Computing, 1985

1985-01-01

Special supplement to "Library Journal" and "School Library Journal" covers topics of interest to school, public, academic, and special libraries planning for automation: microcomputer use, readings in automation, online searching, databases of microcomputer software, public access to microcomputers, circulation, creating a…

UPC Language and Library Specifications, Version 1.3

Energy Technology Data Exchange (ETDEWEB)

UPC Consortium; Bonachea, Dan; Funck, Gary

2013-11-16

UPC is an explicitly parallel extension to the ISO C 99 Standard. UPC follows the partitioned global address space programming model. This document is the formal specification for the UPC language and library syntax and semantics, and supersedes prior specification version 1.2 (LBNL-59208).

How Pennsylvania School Libraries Pay Off: Investments in Student Achievement and Academic Standards

Science.gov (United States)

Lance, Keith Curry; Schwarz, Bill

2012-01-01

The purpose of this study was to examine the impact of Pennsylvania school library programs on student learning--specifically, the infrastructure (staffing, budgets, collections, technology, and access hours) that contributes most to student achievement, the costs and benefits associated with them, and the gap between current Pennsylvania school…

Combinatorial Dansyl Library and its Applications to pH-Responsive Probes.

Science.gov (United States)

Hong, Seong Cheol; Murale, Dhiraj P; Lee, Jun-Seok

2016-01-01

Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

Libraries on the MOVE.

Science.gov (United States)

Edgar, Jim; And Others

1986-01-01

Presents papers from Illinois State Library and Shawnee Library System's "Libraries on the MOVE" conference focusing on how libraries can impact economic/cultural climate of an area. Topics addressed included information services of rural libraries; marketing; rural library development; library law; information access; interagency…

Arrangement and processing of monographic publications in youth sections of public libraries

Directory of Open Access Journals (Sweden)

Mateja Ločniškar-Fidler

2006-01-01

Full Text Available A systematic and transparent layout of library material on book shelves of public libraries is one of the essential conditions for successful viewing and searching of materials. The research tried to determine the contemporary classification system of library material for the youth. The data needed for the research was gathered and analyzed by a questionnaire completed by five randomly selected central public libraries. Special collections, arrangement and classification of certain fiction and specialized monographic publications for infants, teenagers and adolescents were analyzed. It was of our interest to observe whether the libraries assign the elements of a call number - which are evident on the library material and in online catalogs – according to standards and current instructions. The article also focuses on the unity and differences of the technical processing, and on color and/or image of labels which additionally explain the classification and the contents of the monographic publications for the youth.

Comparison of Iranian National Medical Library with digital libraries of selected countries.

Science.gov (United States)

Zare-Farashbandi, Firoozeh; Najafi, Nayere Sadat Soleimanzade; Atashpour, Bahare

2014-01-01

The important role of information and communication technologies and their influence on methods of storing, retrieving information in digital libraries, has not only changed the meanings behind classic library activates but has also created great changes in their services. However, it seems that not all digital libraries provide their users with similar services and only some of them are successful in fulfilling their role in digital environment. The Iranian National Medical library is among those that appear to come short compared to other digital libraries around the world. By knowing the different services provided by digital libraries worldwide, one can evaluate the services provided by Iranian National Medical library. The goal of this study is a comparison between Iranian National Medical library and digital libraries of selected countries. This is an applied study and uses descriptive - survey method. The statistical population is the digital libraries around the world which were actively providing library services between October and December 2011 and were selected by using the key word "Digital Library" in Google search engine. The data-gathering tool was direct access to the websites of these digital libraries. The statistical study is descriptive and Excel software was used for data analysis and plotting of the charts. The findings showed that among the 33 digital libraries investigated worldwide, most of them provided Browse (87.87%), Search (84.84%), and Electronic information retrieval (57.57%) services. The "Help" in public services (48/48%) and "Interlibrary Loan" in traditional services (27/27%) had the highest frequency. The Iranian National Medical library provides more digital services compared to other libraries but has less classic and public services and has less than half of possible public services. Other than Iranian National Medical library, among the 33 libraries investigated, the leaders in providing different services are Library of

Organic Contaminants Library for the Sample Analysis at Mars

Science.gov (United States)

Misra, P.; Garcia-Sanchez, R.; Canham, J.; Mahaffy, P. R.

2012-12-01

A library containing mass spectra for Sample Analysis at Mars (SAM) materials has been developed with the purpose of contamination identification and control. Based on analysis of the Gas Chromatography-Mass Spectrometric (GCMS) data through thermal desorption, organic compounds were successfully identified from material samples, such as polymers, paints and adhesives. The library contains the spectra for all the compounds found in each of these analyzed files and is supplemented by a file information spreadsheet, a spreadsheet-formatted library for easy searching, and a Perfluorotributylamine (PFTBA) based normalization protocol to make corrections to SAM data in order to meet the standard set by commercial libraries. An example of the library in use can be seen in Figure 1, where the abundances match closely, the spectral shape is retained, and the library picks up on it with an 88% identification probability. Of course, there are also compounds that have not been identified and are retained as unknowns. The library we have developed, along with its supplemental materials, is useful from both organizational and practical viewpoints. Through them we are able to organize large volumes of GCMS data, while at the same time breaking down the components that each material sample is made of. This approach in turn allows us straightforward and fast access to information that will be critical while performing analysis on the data recorded by the SAM instrumentation. In addition, the normalization protocol dramatically increased the identification probability. In SAM GCMS, PFTBA signals were obfuscated, resulting in library matches far away from PFTBA; by using the normalization protocol we were able to transform it into a 92% probable spectral match for PFTBA. The project has demonstrated conclusively that the library is successful in identifying unknown compounds utilizing both the Automated Mass Spectral Deconvolution & Identification System (AMDIS) and the Ion

Chapter 6. Operation of electrolytic cell in standard operating practices

International Nuclear Information System (INIS)

Yanko, E.A.; Kabirov, Sh.O.; Safiev, Kh.; Azizov, B.S.; Mirpochaev, Kh.A.

2011-01-01

This chapter is devoted to operation of electrolytic cell in standard operating practices. Therefore, the electrolyte temperature, the composition of electrolyte, including the level of metals was considered. The regulation of electrolyte composition by liquidus temperature and electrolyte overheating was studied. Damping of anode effects was studied as well. Maintenance of electrolytic cells was described. Heat and energy balances of aluminium electrolytic cells were considered.

A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton

Directory of Open Access Journals (Sweden)

Juan Nunez-Iglesias

2018-02-01

Full Text Available We present Skan (Skeleton analysis, a Python library for the analysis of the skeleton structures of objects. It was inspired by the “analyse skeletons” plugin for the Fiji image analysis software, but its extensive Application Programming Interface (API allows users to examine and manipulate any intermediate data structures produced during the analysis. Further, its use of common Python data structures such as SciPy sparse matrices and pandas data frames opens the results to analysis within the extensive ecosystem of scientific libraries available in Python. We demonstrate the validity of Skan’s measurements by comparing its output to the established Analyze Skeletons Fiji plugin, and, with a new scanning electron microscopy (SEM-based method, we confirm that the malaria parasite Plasmodium falciparum remodels the host red blood cell cytoskeleton, increasing the average distance between spectrin-actin junctions.

A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton.

Science.gov (United States)

Nunez-Iglesias, Juan; Blanch, Adam J; Looker, Oliver; Dixon, Matthew W; Tilley, Leann

2018-01-01

We present Skan (Skeleton analysis), a Python library for the analysis of the skeleton structures of objects. It was inspired by the "analyse skeletons" plugin for the Fiji image analysis software, but its extensive Application Programming Interface (API) allows users to examine and manipulate any intermediate data structures produced during the analysis. Further, its use of common Python data structures such as SciPy sparse matrices and pandas data frames opens the results to analysis within the extensive ecosystem of scientific libraries available in Python. We demonstrate the validity of Skan's measurements by comparing its output to the established Analyze Skeletons Fiji plugin, and, with a new scanning electron microscopy (SEM)-based method, we confirm that the malaria parasite Plasmodium falciparum remodels the host red blood cell cytoskeleton, increasing the average distance between spectrin-actin junctions.

Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements.

Science.gov (United States)

Basketter, David; Kolle, Susanne N; Schrage, Arnhild; Honarvar, Naveed; Gamer, Armin O; van Ravenzwaay, Bennard; Landsiedel, Robert

2012-08-01

The local lymph node assay (LLNA) is the preferred test for identification of skin-sensitizing substances by measuring radioactive thymidine incorporation into the lymph node. To facilitate acceptance of nonradioactive variants, validation authorities have published harmonized minimum performance standards (PS) that the alternative endpoint assay must meet. In the present work, these standards were applied to a variant of the LLNA based on lymph node cell counts (LNCC) run in parallel as a control with the standard LLNA with radioactivity measurements, with threshold concentrations (EC3) being determined for the sensitizers. Of the 22 PS chemicals tested in this study, 21 yielded the same results from standard radioactivity and cell count measurements; only 2-mercaptobenzothiazole was positive by LLNA but negative by LNCC. Of the 16 PS positives, 15 were positive by LLNA and 14 by LNCC; methylmethacrylate was not identified as sensitizer by either of the measurements. Two of the six PS negatives tested negative in our study by both LLNA and LNCC. Of the four PS negatives which were positive in our study, chlorobenzene and methyl salicylate were tested at higher concentrations than the published PS, whereas the corresponding concentrations resulted in consistent negative results. Methylmethacrylate and nickel chloride tested positive within the concentration range used for the published PS. The results indicate cell counts and radioactive measurements are in good accordance within the same LLNA using the 22 PS test substances. Comparisons with the published PS results may, however, require balanced analysis rather than a simple checklist approach. Copyright © 2011 John Wiley & Sons, Ltd.

Construction of a Full-Length Enriched cDNA Library and Preliminary Analysis of Expressed Sequence Tags from Bengal Tiger Panthera tigris tigris

Science.gov (United States)

Liu, Changqing; Liu, Dan; Guo, Yu; Lu, Taofeng; Li, Xiangchen; Zhang, Minghai; Ma, Jianzhang; Ma, Yuehui; Guan, Weijun

2013-01-01

In this study, a full-length enriched cDNA library was successfully constructed from Bengal tiger, Panthera tigris tigris, the most well-known wild Animal. Total RNA was extracted from cultured Bengal tiger fibroblasts in vitro. The titers of primary and amplified libraries were 1.28 × 106 pfu/mL and 1.56 × 109 pfu/mL respectively. The percentage of recombinants from unamplified library was 90.2% and average length of exogenous inserts was 0.98 kb. A total of 212 individual ESTs with sizes ranging from 356 to 1108 bps were then analyzed. The BLASTX score revealed that 48.1% of the sequences were classified as a strong match, 45.3% as nominal and 6.6% as a weak match. Among the ESTs with known putative function, 26.4% ESTs were found to be related to all kinds of metabolisms, 19.3% ESTs to information storage and processing, 11.3% ESTs to posttranslational modification, protein turnover, chaperones, 11.3% ESTs to transport, 9.9% ESTs to signal transducer/cell communication, 9.0% ESTs to structure protein, 3.8% ESTs to cell cycle, and only 6.6% ESTs classified as novel genes. By EST sequencing, a full-length gene coding ferritin was identified and characterized. The recombinant plasmid pET32a-TAT-Ferritin was constructed, coded for the TAT-Ferritin fusion protein with two 6× His-tags in N and C-terminal. After BCA assay, the concentration of soluble Trx-TAT-Ferritin recombinant protein was 2.32 ± 0.12 mg/mL. These results demonstrated that the reliability and representativeness of the cDNA library attained to the requirements of a standard cDNA library. This library provided a useful platform for the functional genome and transcriptome research of Bengal tigers. PMID:23708105

Construction of a Full-Length Enriched cDNA Library and Preliminary Analysis of Expressed Sequence Tags from Bengal Tiger Panthera tigris tigris

Directory of Open Access Journals (Sweden)

Changqing Liu

2013-05-01

Full Text Available In this study, a full-length enriched cDNA library was successfully constructed from Bengal tiger, Panthera tigris tigris, the most well-known wild Animal. Total RNA was extracted from cultured Bengal tiger fibroblasts in vitro. The titers of primary and amplified libraries were 1.28 × 106 pfu/mL and 1.56 × 109 pfu/mL respectively. The percentage of recombinants from unamplified library was 90.2% and average length of exogenous inserts was 0.98 kb. A total of 212 individual ESTs with sizes ranging from 356 to 1108 bps were then analyzed. The BLASTX score revealed that 48.1% of the sequences were classified as a strong match, 45.3% as nominal and 6.6% as a weak match. Among the ESTs with known putative function, 26.4% ESTs were found to be related to all kinds of metabolisms, 19.3% ESTs to information storage and processing, 11.3% ESTs to posttranslational modification, protein turnover, chaperones, 11.3% ESTs to transport, 9.9% ESTs to signal transducer/cell communication, 9.0% ESTs to structure protein, 3.8% ESTs to cell cycle, and only 6.6% ESTs classified as novel genes. By EST sequencing, a full-length gene coding ferritin was identified and characterized. The recombinant plasmid pET32a-TAT-Ferritin was constructed, coded for the TAT-Ferritin fusion protein with two 6× His-tags in N and C-terminal. After BCA assay, the concentration of soluble Trx-TAT-Ferritin recombinant protein was 2.32 ± 0.12 mg/mL. These results demonstrated that the reliability and representativeness of the cDNA library attained to the requirements of a standard cDNA library. This library provided a useful platform for the functional genome and transcriptome research of Bengal tigers.

A Content Analysis of Library Vendor Privacy Policies: Do They Meet Our Standards?

Science.gov (United States)

Magi, Trina J.

2010-01-01

Librarians have a long history of protecting user privacy, but they have done seemingly little to understand or influence the privacy policies of library resource vendors that increasingly collect user information through Web 2.0-style personalization features. After citing evidence that college students value privacy, this study used content…

Decay of the pulsed thermal neutron flux in two-zone hydrogenous systems - Monte Carlo simulations using MCNP standard data libraries

International Nuclear Information System (INIS)

Wiacek, Urszula; Krynicka, Ewa

2006-01-01

Pulsed neutron experiments in two-zone spherical and cylindrical geometry has been simulated using the MCNP code. The systems are built of hydrogenous materials. The inner zone is filled with aqueous solutions of absorbers (H 3 BO 3 or KCl). It is surrounded by the outer zone built of Plexiglas. The system is irradiated with the pulsed thermal neutron flux and the thermal neutron decay in time is observed. Standard data libraries of the thermal neutron scattering cross-sections of hydrogen in hydrogenous substances have been used to simulate the neutron transport. The time decay constant of the fundamental mode of the thermal neutron flux determined in each simulation has been compared with the corresponding result of the real pulsed neutron experiment

Determining Gate Count Reliability in a Library Setting

Directory of Open Access Journals (Sweden)

Jeffrey Phillips

2016-09-01

Full Text Available Objective – Patron counts are a common form of measurement for library assessment. To develop accurate library statistics, it is necessary to determine any differences between various counting devices. A yearlong comparison between card reader turnstiles and laser gate counters in a university library sought to offer a standard percentage of variance and provide suggestions to increase the precision of counts. Methods – The collection of library exit counts identified the differences between turnstile and laser gate counter data. Statistical software helped to eliminate any inaccuracies in the collection of turnstile data, allowing this data set to be the base for comparison. Collection intervals were randomly determined and demonstrated periods of slow, average, and heavy traffic. Results – After analyzing 1,039,766 patron visits throughout a year, the final totals only showed a difference of .43% (.0043 between the two devices. The majority of collection periods did not exceed a difference of 3% between the counting instruments. Conclusion – Turnstiles card readers and laser gate counters provide similar levels of reliability when measuring patron activity. Each system has potential counting inaccuracies, but several methods exist to create more precise totals. Turnstile card readers are capable of offering greater detail involving patron identity, but their high cost makes them inaccessible for libraries with lower budgets. This makes laser gate counters an affordable alternative for reliable patron counting in an academic library.

Electronic Data Interchange (EDI) for Libraries and Publishers.

Science.gov (United States)

Santosuosso, Joe

1992-01-01

Defines electronic data interchange (EDI) as the exchange of data between computer systems without human intervention or interpretation. Standards are discussed; and the implementation of EDI in libraries and the serials publishing community in the areas of orders and acquisitions, claims, and invoice processing is described. (LRW)

Generation of thermostable Moloney murine leukemia virus reverse transcriptase variants using site saturation mutagenesis library and cell-free protein expression system.

Science.gov (United States)

Katano, Yuta; Li, Tongyang; Baba, Misato; Nakamura, Miyo; Ito, Masaaki; Kojima, Kenji; Takita, Teisuke; Yasukawa, Kiyoshi

2017-12-01

We attempted to increase the thermostability of Moloney murine leukemia virus (MMLV) reverse transcriptase (RT). The eight-site saturation mutagenesis libraries corresponding to Ala70-Arg469 in the whole MMLV RT (Thr24-Leu671), in each of which 1 out of 50 amino acid residues was replaced with other amino acid residue, were constructed. Seven-hundred and sixty eight MMLV RT clones were expressed using a cell-free protein expression system, and their thermostabilities were assessed by the temperature of thermal treatment at which they retained cDNA synthesis activity. One clone D200C was selected as the most thermostable variant. The highest temperature of thermal treatment at which D200C exhibited cDNA synthesis activity was 57ºC, which was higher than for WT (53ºC). Our results suggest that a combination of site saturation mutagenesis library and cell-free protein expression system might be useful for generation of thermostable MMLV RT in a short period of time for expression and selection.

Factors of Engagement: Professional Standards and the Library Science Internship

Science.gov (United States)

Dotson, Kaye B.; Dotson-Blake, Kylie P.

2015-01-01

In today's technological world, school librarians planning to be leaders should be ready to keep up with advances in standards significant to the profession. The professional standards, specifically American Association of School Librarians (AASL) Standards and International Society for Technology in Education (ISTE) Standards for Coaches offer…

Preparation of Small RNA NGS Libraries from Biofluids.

Science.gov (United States)

Etheridge, Alton; Wang, Kai; Baxter, David; Galas, David

2018-01-01

Next generation sequencing (NGS) is a powerful method for transcriptome analysis. Unlike other gene expression profiling methods, such as microarrays, NGS provides additional information such as splicing variants, sequence polymorphisms, and novel transcripts. For this reason, NGS is well suited for comprehensive profiling of the wide range of extracellular RNAs (exRNAs) in biofluids. ExRNAs are of great interest because of their possible biological role in cell-to-cell communication and for their potential use as biomarkers or for therapeutic purposes. Here, we describe a modified protocol for preparation of small RNA libraries for NGS analysis. This protocol has been optimized for use with low-input exRNA-containing samples, such as plasma or serum, and has modifications designed to reduce the sequence-specific bias typically encountered with commercial small RNA library construction kits.

The USF Libraries Virtual Library Project: A Blueprint for Development.

Science.gov (United States)

Metz-Wiseman, Monica; Silver, Susan; Hanson, Ardis; Johnston, Judy; Grohs, Kim; Neville, Tina; Sanchez, Ed; Gray, Carolyn

This report of the Virtual Library Planning Committee (VLPC) is intending to serve as a blueprint for the University of South Florida (USF) Libraries as it shifts from print to digital formats in its evolution into a "Virtual Library". A comprehensive planning process is essential for the USF Libraries to make optimum use of technology,…

Research data services in veterinary medicine libraries.

Science.gov (United States)

Kerby, Erin E

2016-10-01

The study investigated veterinary medicine librarians' experience with and perceptions of research data services. Many academic libraries have begun to offer research data services in response to researchers' increased need for data management support. To date, such services have typically been generic, rather than discipline-specific, to appeal to a wide variety of researchers. An online survey was deployed to identify trends regarding research data services in veterinary medicine libraries. Participants were identified from a list of contacts from the MLA Veterinary Medical Libraries Section. Although many respondents indicated that they have a professional interest in research data services, the majority of veterinary medicine librarians only rarely or occasionally provide data management support as part of their regular job responsibilities. There was little consensus as to whether research data services should be core to a library's mission despite their perceived importance to the advancement of veterinary research. Furthermore, most respondents stated that research data services are just as or somewhat less important than the other services that they provide and feel only slightly or somewhat prepared to offer such services. Lacking a standard definition of "research data" and a common understanding of precisely what research data services encompass, it is difficult for veterinary medicine librarians and libraries to define and understand their roles in research data services. Nonetheless, they appear to have an interest in learning more about and providing research data services.

Our Stories Transforming Our Libraries: The York County Library System

Directory of Open Access Journals (Sweden)

Mina Edmondson

2016-11-01

Full Text Available These narratives chronicle the authors’ journeys to collaborate and discover the transformative impact that stories have on library culture and library staff. This study describes a research collaboration between York County Libraries and Penn State York. In Phase I, we collected stories from library staff as the library system was being challenged to reimage public libraries for the future. The major themes and types of organizational stories identified in the initial narrative project were presented during a county-wide all-staff in-service training. The library District Consultant (first author and the Penn State professor (second author then facilitated a workshop designed to lead staff in their exploration of these topics and generate a written record of their storytelling/discussions. This data became the basis for Phase II of the project and allowed the system to strategically assess its evolving culture and identity.

Digital library initiative in an Indian research library: an experience report

International Nuclear Information System (INIS)

Venkadesan, S.; Narayanan, A.

1999-01-01

Libraries all over the world are transiting from the traditional print only era to the electronic era. The migration to an electronic library involves the understanding of several issues and requirements at the planning stage itself. This paper describes the various aspects of building a digital library system. Experience of implementing certain strategies in the IGCAR library is discussed in detail. The components of the digital library and the various access levels are discussed with examples. Finally, samples of the IGCAR library web site and the Newsletter web site are shown. (author)

MOX Cross-Section Libraries for ORIGEN-ARP

International Nuclear Information System (INIS)

Gauld, I.C.

2003-01-01

The use of mixed-oxide (MOX) fuel in commercial nuclear power reactors operated in Europe has expanded rapidly over the past decade. The predicted characteristics of MOX fuel such as the nuclide inventories, thermal power from decay heat, and radiation sources are required for design and safety evaluations, and can provide valuable information for non-destructive safeguards verification activities. This report describes the development of computational methods and cross-section libraries suitable for the analysis of irradiated MOX fuel with the widely-used and recognized ORIGEN-ARP isotope generation and depletion code of the SCALE (Standardized Computer Analyses for Licensing Evaluation) code system. The MOX libraries are designed to be used with the Automatic Rapid Processing (ARP) module of SCALE that interpolates appropriate values of the cross sections from a database of parameterized cross-section libraries to create a problem-dependent library for the burnup analysis. The methods in ORIGEN-ARP, originally designed for uranium-based fuels only, have been significantly upgraded to handle the larger number of interpolation parameters associated with MOX fuels. The new methods have been incorporated in a new version of the ARP code that can generate libraries for low-enriched uranium (LEU) and MOX fuel types. The MOX data libraries and interpolation algorithms in ORIGEN-ARP have been verified using a database of declared isotopic concentrations for 1042 European MOX fuel assemblies. The methods and data are validated using a numerical MOX fuel benchmark established by the Organization for Economic Cooperation and Development (OECD) Working Group on burnup credit and nuclide assay measurements for irradiated MOX fuel performed as part of the Belgonucleaire ARIANE International Program

FROM THE SCHOOL LIBRARY ACTIVITIES TO STRENGTHEN CITIZENS LIVING STANDARDS IN THE TEACHERS / ACTIVIDADES DESDE LA BIBLIOTECA ESCOLAR PARA FORTALECER LAS NORMAS DE CONVIVENCIA CIUDADANA EN LOS PROFESORES

Directory of Open Access Journals (Sweden)

Elizabeth Manso Armas

2013-09-01

Full Text Available School libraries offer services that facilitate access to information. Are conducted, and various activities that contribute to the formation of the love of reading and books, as well as the training of students and teachers in the use of information. This paper proposes a set of activities that complement the systematic work that takes place in the classroom, contribute to the cultural development of pupils and teachers, as well as provide a means of recreation. The practical significance lays in the introduction, in school practice, educational activities to promote reading aimed at strengthening coexistence standards in the teacher and their newness in the relationship between civic education process and rules of coexistence, defining the latter as the content of this process and in this sense substantiate the potential of the library.

News from the Library: The 'long tail' Library

CERN Multimedia

CERN Library

2012-01-01

"The term 'long tail' has gained popularity in recent times as describing the retailing strategy of selling a large number of unique items with relatively small quantities sold of each usually in addition to selling fewer popular items in large quantities. The long tail was popularized by Chris Anderson, who mentioned Amazon.com, Apple and Yahoo! as examples of businesses applying this strategy." *   If we leave the business environment and move to the world of libraries, we still see this "long tail". Usually, only a small portion of a library's book collection accounts for the majority of its loans. On the other hand, there are a variety of "niche information needs" that might not be met, as libraries cannot afford to build up huge collections of documents available just-in-case. However, the networked environment of today's libraries can offer a solution. Online networks of libraries ca...

SWATH Mass Spectrometry Performance Using Extended Peptide MS/MS Assay Libraries*

Science.gov (United States)

Wu, Jemma X.; Song, Xiaomin; Pascovici, Dana; Zaw, Thiri; Care, Natasha; Krisp, Christoph; Molloy, Mark P.

2016-01-01

The use of data-independent acquisition methods such as SWATH for mass spectrometry based proteomics is usually performed with peptide MS/MS assay libraries which enable identification and quantitation of peptide peak areas. Reference assay libraries can be generated locally through information dependent acquisition, or obtained from community data repositories for commonly studied organisms. However, there have been no studies performed to systematically evaluate how locally generated or repository-based assay libraries affect SWATH performance for proteomic studies. To undertake this analysis, we developed a software workflow, SwathXtend, which generates extended peptide assay libraries by integration with a local seed library and delivers statistical analysis of SWATH-quantitative comparisons. We designed test samples using peptides from a yeast extract spiked into peptides from human K562 cell lysates at three different ratios to simulate protein abundance change comparisons. SWATH-MS performance was assessed using local and external assay libraries of varying complexities and proteome compositions. These experiments demonstrated that local seed libraries integrated with external assay libraries achieve better performance than local assay libraries alone, in terms of the number of identified peptides and proteins and the specificity to detect differentially abundant proteins. Our findings show that the performance of extended assay libraries is influenced by the MS/MS feature similarity of the seed and external libraries, while statistical analysis using multiple testing corrections increases the statistical rigor needed when searching against large extended assay libraries. PMID:27161445

Students lead the library the importance of student contributions to the academic library

CERN Document Server

Arnold-Garza, Sara

2017-01-01

In six parts-Students as Employees, Students as Curators, Students as Ambassadors, the Library as Client, Student Groups as Library Leaders, and Students as Library Designers-Students Lead the Library provides case studies of programs and initiatives that seek student input, assistance, and leadership in the academic library. Through the library, students can develop leadership skills, cultivate high levels of engagement, and offer peer learning opportunities. Through the students, libraries can create participatory design processes, enhancement and transformation of the library's core functions, and expressed library value for stakeholders.

Analyzing Archival Intelligence: A Collaboration Between Library Instruction and Archives

Directory of Open Access Journals (Sweden)

Merinda Kaye Hensley

2014-07-01

Full Text Available Although recent archival scholarship promotes the use of primary sources for developing students’ analytical research skills, few studies focus on standards or protocols for teaching or assessing archival instruction. Librarians have designed and tested standards and learning assessment strategies for library instruction and archivists would do well to collaborate with and learn from their experience. This study examines lessons learned from one such collaboration between an instructional services librarian and archivist to evaluate and enhance archival instruction in the University Archives’ Student Life and Culture Archival Program (SLC Archives at the University of Illinois at Urbana-Champaign Library. Based on evaluative data from a student survey and in-depth interviews, the authors offer strategies for meeting and exceeding learning outcomes for archival intelligence more successfully.

Combined whole-cell high-throughput functional screening for identification of new nicotinamidases/pyrazinamidases in metagenomic/polygenomic libraries

Directory of Open Access Journals (Sweden)

Rubén Zapata-Pérez

2016-11-01

Full Text Available Nicotinamidases catalyze the hydrolysis of the amide bond in nicotinamide to produce ammonia and nicotinic acid. These enzymes are an essential component of the NAD+ salvage pathway and are implicated in the viability of several pathogenic organisms. Its absence in humans makes them a promising drug target. In addition, although they are key analytical biocatalysts for screening modulators in relevant biomedical enzymes, such as sirtuins and poly-ADP-ribosyltransferases, no commercial sources are available. Surprisingly, the finding of an affordable source of nicotinamidase from metagenomic libraries is hindered by the absence of a suitable and fast screening method. In this manuscript, we describe the development of two new whole-cell methods using the chemical property of one of the products formed in the enzymatic reaction (pyrazinoic or nicotinic acid to form colored complexes with stable iron salts, such as ammonium ferrous sulfate or sodium nitroprusside. After optimization of the assay conditions, a fosmid polygenomic expression library obtained from deep-sea mesophilic bacteria was screened, discovering several positive clones with the ammonium ferrous sulfate method. Their quantitative rescreening with the sodium nitroprusside method allowed the finding of the first nicotinamidase with balanced catalytic efficiency towards nicotinamide (nicotinamidase activity and pyrazinamide (pyrazinamidase activity. Its biochemical characterization has also made possible the development of the first high-throughput whole-cell method for prescreening of new nicotinamidase inhibitors by the naked eye, saving time and costs in the design of future antimicrobial and antiparasitic agents.

Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries.

Science.gov (United States)

Zapata-Pérez, Rubén; García-Saura, Antonio G; Jebbar, Mohamed; Golyshin, Peter N; Sánchez-Ferrer, Álvaro

2016-01-01

Nicotinamidases catalyze the hydrolysis of the amide bond in nicotinamide (NAM) to produce ammonia and nicotinic acid (NA). These enzymes are an essential component of the NAD + salvage pathway and are implicated in the viability of several pathogenic organisms. Its absence in humans makes them a promising drug target. In addition, although they are key analytical biocatalysts for screening modulators in relevant biomedical enzymes, such as sirtuins and poly-ADP-ribosyltransferases, no commercial sources are available. Surprisingly, the finding of an affordable source of nicotinamidase from metagenomic libraries is hindered by the absence of a suitable and fast screening method. In this manuscript, we describe the development of two new whole-cell methods using the chemical property of one of the products formed in the enzymatic reaction (pyrazinoic or NA) to form colored complexes with stable iron salts, such as ammonium ferrous sulfate or sodium nitroprusside (SNP). After optimization of the assay conditions, a fosmid polygenomic expression library obtained from deep-sea mesophilic bacteria was screened, discovering several positive clones with the ammonium ferrous sulfate method. Their quantitative rescreening with the SNP method allowed the finding of the first nicotinamidase with balanced catalytic efficiency toward NAM (nicotinamidase activity) and pyrazinamide (pyrazinamidase activity). Its biochemical characterization has also made possible the development of the first high-throughput whole-cell method for prescreening of new nicotinamidase inhibitors by the naked eye, saving time and costs in the design of future antimicrobial and antiparasitic agents.

Academic Library Administrators Perceive Value in Their Librarians’ Research

Directory of Open Access Journals (Sweden)

Elaine Sullo

2014-09-01

Full Text Available A Review of: Perkins, G.H. & Slowik, A.J.W. (2013. The value of research in academic libraries. College & Research Libraries, 74(2, 143-158. Retrieved from http://crl.acrl.org/content/74/2/143.full.pdf+html Abstract Objective – To explore academic library administrators’ perceived value of their librarians’ research, specifically the importance to the profession and the library community. Design – Qualitative, exploratory study using a survey questionnaire. Setting – Academic libraries in the United States of America. Subjects – 23 library administrators. Methods – During the summer of 2010, one of the authors conducted 20-30 minute telephone interviews with 23 academic library administrators. Interviews were recorded and transcribed for coding. Interview questions 1-3 and 8-19 were content-analyzed; the authors described common themes for each of these questions. Items 4-7 had Likert scale response formats, and a mean and standard deviation were computed for each of these items. Main Results – The benefits of librarians’ research included fulfilling tenure-track requirements, enriching relationships with teaching faculty, library faculty recognition, improved services and programs, collaboration with others, research result application to daily issues, development as librarians, and improved knowledge of the research field. The perceived current changes and future issues for university libraries included increased digitization of collections, scholarly communication, and expanded instructional engagement of faculty and students, as well as future economic downturn and budget cuts. Administrators noted several methods that influenced their thinking: professional meetings, reading professional journals, informal discussions with colleagues, and social media such as Facebook and Twitter. Academic library administrators used a variety of methods to support their librarians’ research. These included tenure-track requirements

Research data services in veterinary medicine libraries

Directory of Open Access Journals (Sweden)

Erin E. Kerby, MSI

2017-01-01

Conclusions: Lacking a standard definition of ‘‘research data’’ and a common understanding of precisely what research data services encompass, it is difficult for veterinary medicine librarians and libraries to define and understand their roles in research data services. Nonetheless, they appear to have an interest in learning more about and providing research data services.

iTesla Power Systems Library (iPSL): A Modelica library for phasor time-domain simulations

Science.gov (United States)

Vanfretti, L.; Rabuzin, T.; Baudette, M.; Murad, M.

The iTesla Power Systems Library (iPSL) is a Modelica package providing a set of power system components for phasor time-domain modeling and simulation. The Modelica language provides a systematic approach to develop models using a formal mathematical description, that uniquely specifies the physical behavior of a component or the entire system. Furthermore, the standardized specification of the Modelica language (Modelica Association [1]) enables unambiguous model exchange by allowing any Modelica-compliant tool to utilize the models for simulation and their analyses without the need of a specific model transformation tool. As the Modelica language is being developed with open specifications, any tool that implements these requirements can be utilized. This gives users the freedom of choosing an Integrated Development Environment (IDE) of their choice. Furthermore, any integration solver can be implemented within a Modelica tool to simulate Modelica models. Additionally, Modelica is an object-oriented language, enabling code factorization and model re-use to improve the readability of a library by structuring it with object-oriented hierarchy. The developed library is released under an open source license to enable a wider distribution and let the user customize it to their specific needs. This paper describes the iPSL and provides illustrative application examples.

An assessment of collections at the University of Wisconsin-Madison Health Sciences Libraries: drug resistance.

Science.gov (United States)

Bergen, P L; Nemec, D

1999-01-01

In December 1997, the authors completed an in-depth collection assessment project at the University of Wisconsin-Madison Health Sciences Libraries. The purpose was to develop a framework for future collection assessment projects by completing a multifaceted evaluation of the libraries' monograph and serial collections in the subject area of drug resistance. Evaluators adapted and synthesized several traditional collection assessment tools, including shelflist measurement, bibliography and standard list checking, and citation analysis. Throughout the project, evaluators explored strategies to overcome some of the problems inherent in the application of traditional collection assessment methods to the evaluation of biomedical collections. Their efforts resulted in the identification of standard monographs and core journals for the subject area, a measurement of the collections' strength relative to the collections of benchmark libraries, and a foundation for future collection development within the subject area. The project's primary outcome was a collection assessment methodology that has potential application to both internal and cooperative collection development in medical, pharmaceutical, and other health sciences libraries.

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.

Science.gov (United States)

Welford, Amanda J; Caldwell, John J; Liu, Manjuan; Richards, Meirion; Brown, Nathan; Lomas, Cara; Tizzard, Graham J; Pitak, Mateusz B; Coles, Simon J; Eccles, Suzanne A; Raynaud, Florence I; Collins, Ian

2016-04-11

The 2,11-cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran-based compounds designed to augment a typical medicinal chemistry library screen. Ring-closing metathesis, lactonisation and SmI2 -mediated methods were exemplified and applied to the installation of a third ring to mimic the nine-membered ring of the 2,11-cembranoids. The library was assessed for aqueous solubility and permeability, with a chemical-space analysis performed for comparison to the family of cembranoid natural products and a sample set of a screening library. Preliminary investigations in cancer cells showed that the simpler scaffolds could recapitulate the reported anti-migratory activity of the natural products. © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

CGNS Mid-Level Software Library and Users Guide

Science.gov (United States)

Poirier, Diane; Smith, Charles A. (Technical Monitor)

1998-01-01

The "CFD General Notation System" (CGNS) consists of a collection of conventions, and conforming software, for the storage and retrieval of Computational Fluid Dynamics (CFD) data. It facilitates the exchange of data between sites and applications, and helps stabilize the archiving of aerodynamic data. This effort was initiated in order to streamline the procedures in exchanging data and software between NASA and its customers, but the goal is to develop CGNS into a National Standard for the exchange of aerodynamic data. The CGNS development team is comprised of members from Boeing Commercial Airplane Group, NASA-Ames, NASA-Langley, NASA-Lewis, McDonnell-Douglas Corporation (now Boeing-St. Louis), Air Force-Wright Lab., and ICEM-CFD Engineering. The elements of CGNS address all activities associated with the storage of data on external media and its movement to and from application programs. These elements include: - The Advanced Data Format (ADF) Database manager, consisting of both a file format specification and its I/O software, which handles the actual reading and writing of data from and to external storage media; - The Standard Interface Data Structures (SIDS), which specify the intellectual content of CFD data and the conventions governing naming and terminology; - The SIDS-to-ADF File Mapping conventions, which specify the exact location where the CFD data defined by the SIDS is to be stored within the ADF file(s); and - The CGNS Mid-level Library, which provides CFD-knowledgeable routines suitable for direct installation into application codes. The CGNS Mid-level Library was designed to ease the implementation of CGNS by providing developers with a collection of handy I/O functions. Since knowledge of the ADF core is not required to use this library, it will greatly facilitate the task of interfacing with CGNS. There are currently 48 user callable functions that comprise the Mid-level library and are described in the Users Guide. The library is written in

302 Historical Background, Development and Standard of Public ...

African Journals Online (AJOL)

User

Abstract. It has been observed that public libraries in Nigeria have not developed as expected. Instead of moving forward, they are still very backward in terms of development. This paper examines the historical background development and standard of public libraries services in Nigeria. It looks at the roles and the sources ...

Neurorestorative clinical application standards for the culture and quality control of olfactory ensheathing cells

Directory of Open Access Journals (Sweden)

Xiao J

2017-09-01

Full Text Available Juan Xiao,1,2 Lin Chen,3 Gengsheng Mao,1 Wenyong Gao,1,2 Ming Lu,4 Xijing He,5 Hongyun Huang1,2 On behalf of the Neurorestoratology Professional Committee of Chinese Medical Doctors Association (Chinese Association of Neurorestoratology 1Institute of Neurorestoratology, The General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China; 2Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing, People’s Republic of China; 3Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, People’s Republic of China; 4Department of Neurosurgery, 163 Hospital of PLA (Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, People’s Republic of China; 5Department of Orthopedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xian, Shanxi Provine, People’s Republic of China Abstract: Olfactory ensheathing cells (OECs are a novel type of glial cell that can perform and promote many neurorestorative processes in vivo after transplant. To date, dozens of preclinical and clinical studies have confirmed that OECs have unique restoring effects in animal models and human subjects with neurological degeneration or damage, such as spinal cord injury, stroke, cerebral palsy, traumatic brain injury, and motor neuron disease (amyotrophic lateral sclerosis. To ensure the safety and effectiveness of clinical applications utilizing this type of cell, it is important to standardize cell-culture and quality-control processes. Based on a comprehensive review of published clinical studies, as well as existing methods of OEC culture and quality control currently utilized by hospitals and biomedical enterprises, the Chinese Association of Neurorestoratology has developed a set of standards for the culture and quality control of olfactory ensheathing cells for use in clinical applications. These guidelines include standardized training and management procedures for

Libraries and Learning

Science.gov (United States)

Rainie, Lee

2016-01-01

The majority of Americans think local libraries serve the educational needs of their communities and families pretty well and library users often outpace others in learning activities. But many do not know about key education services libraries provide. This report provides statistics on library usage and presents key education services provided…

The impact of computerisation of library operations on library ...

African Journals Online (AJOL)

The use of computer-based systems in libraries and information units is now a vogue. The era of manual system in library operations is on its way to extinction. Recent developments in information world tend towards a globalized information communication technology (ICT). The library as a dynamic institution cannot afford ...

Library Systems: FY 2014 Public Libraries Survey (Administrative Entity Data)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on library systems around the United States.These data include imputed values for libraries that did not submit information in the FY 2014 data...

Fusion of Library, Archive, Museum, Publisher (LAMP: the NTNU Library Experience

Directory of Open Access Journals (Sweden)

Ke, Hao-Ren

2016-06-01

Full Text Available The convergence of libraries, archives, and museums (LAMs has garnered attention in recent years. Extending the tendency further, National Taiwan Normal University (NTNU fuses the library, archive, museum, and publisher (LAMP functionality together in its library. This article elaborates on the LAMP practices of the NTNU Library, which indicates that without creating new units in a university, its library can play a good role of curating invaluable university assets.

The Homeless in the Public Library: Implications for Access to Libraries.

Science.gov (United States)

Simmons, Randall C.

1985-01-01

Discussion of the homeless in American public libraries focuses on harmless individuals who may be considered nuisance by library staff/patrons. Highlights include literature about problem library patrons, national problem, social issues, major themes (offense to others and library staff, balancing rights, and elitism), and implications for…

A compact phage display human scFv library for selection of antibodies to a wide variety of antigens

Directory of Open Access Journals (Sweden)

Kristensen Peter

2009-01-01

Full Text Available Abstract Background Phage display technology is a powerful new tool for making antibodies outside the immune system, thus avoiding the use of experimental animals. In the early days, it was postulated that this technique would eventually replace hybridoma technology and animal immunisations. However, since this technology emerged more than 20 years ago, there have only been a handful reports on the construction and application of phage display antibody libraries world-wide. Results Here we report the simplest and highly efficient method for the construction of a highly useful human single chain variable fragment (scFv library. The least number of oligonucleotide primers, electroporations and ligation reactions were used to generate a library of 1.5 × 108 individual clones, without generation of sub-libraries. All possible combinations of heavy and light chains, among all immunoglobulin isotypes, were included by using a mixture of primers and overlapping extension PCR. The key difference from other similar libraries was the highest diversity of variable gene repertoires, which was derived from 140 non-immunized human donors. A wide variety of antigens were successfully used to affinity select specific binders. These included pure recombinant proteins, a hapten and complex antigens such as viral coat proteins, crude snake venom and cancer cell surface antigens. In particular, we were able to use standard bio-panning method to isolate antibody that can bind to soluble Aflatoxin B1, when using BSA-conjugated toxin as a target, as demonstrated by inhibition ELISA. Conclusion These results suggested that by using an optimized protocol and very high repertoire diversity, a compact and efficient phage antibody library can be generated. This advanced method could be adopted by any molecular biology laboratory to generate both naïve or immunized libraries for particular targets as well as for high-throughput applications.

Orientation Programs to the Virtual National Libraries in the Arab ...

African Journals Online (AJOL)

pc

2018-03-05

teaching the strategies of web search engines" and "teaching the standards of .... For example, YouTube is used to market particular services and products. ..... [11] Liu, Q., Lo, P., & Itsumura, H. , Measuring the Importance of Library.

What in the World Is a State Library? Issues in State Library Management.

Science.gov (United States)

Weaver, Barbara

1990-01-01

Provides an overview of the various roles of state libraries and discusses several issues of concern to all state libraries: the role of the library within state government; resources sharing; school library development; public library development; automation consulting; continuing education for library professionals; and the leadership role of…

Libraries in society

DEFF Research Database (Denmark)

Kristiansson, Michael; Skouvig, Laura Henriette Christine

2008-01-01

The purpose of the paper is to investigate the phenomenon of openness in relation to library development. The term openness is presented and related to library development from historical and theoretical perspectives. The paper elaborates on the differences over time on to how openness has been...... understood in a library setting. Historically, openness in form of the open shelves played a crucial role in developing the modern public library. The paper examines this openness-centred library policy as adopted by Danish public libraries in the beginning of the 20th century by applying the theories...... by Michel Foucault on discourse and power to the introduction of open shelves. Furthermore, the paper discusses current challenges facing the modern public library in coping with openness issues that follow from changes in society and advances in technology. These influences and developments are not least...

Rapid development of medical imaging tools with open-source libraries.

Science.gov (United States)

Caban, Jesus J; Joshi, Alark; Nagy, Paul

2007-11-01

Rapid prototyping is an important element in researching new imaging analysis techniques and developing custom medical applications. In the last ten years, the open source community and the number of open source libraries and freely available frameworks for biomedical research have grown significantly. What they offer are now considered standards in medical image analysis, computer-aided diagnosis, and medical visualization. A cursory review of the peer-reviewed literature in imaging informatics (indeed, in almost any information technology-dependent scientific discipline) indicates the current reliance on open source libraries to accelerate development and validation of processes and techniques. In this survey paper, we review and compare a few of the most successful open source libraries and frameworks for medical application development. Our dual intentions are to provide evidence that these approaches already constitute a vital and essential part of medical image analysis, diagnosis, and visualization and to motivate the reader to use open source libraries and software for rapid prototyping of medical applications and tools.

Library fingerprints: a novel approach to the screening of virtual libraries.

Science.gov (United States)

Klon, Anthony E; Diller, David J

2007-01-01

We propose a novel method to prioritize libraries for combinatorial synthesis and high-throughput screening that assesses the viability of a particular library on the basis of the aggregate physical-chemical properties of the compounds using a naïve Bayesian classifier. This approach prioritizes collections of related compounds according to the aggregate values of their physical-chemical parameters in contrast to single-compound screening. The method is also shown to be useful in screening existing noncombinatorial libraries when the compounds in these libraries have been previously clustered according to their molecular graphs. We show that the method used here is comparable or superior to the single-compound virtual screening of combinatorial libraries and noncombinatorial libraries and is superior to the pairwise Tanimoto similarity searching of a collection of combinatorial libraries.

E-Library and Traditonal Library Resources Usage: A Comparative ...

African Journals Online (AJOL)

A comparative usage of e-library and traditional resources in Nigerian libraries was examined in this study. A descriptive survey method was adopted and a purposive sampling technique was used to select the sample and the process produced 125 academic, research, and public libraries in Nigeria. A total of 116 cases ...

Organizational prerequisites for the preservation of library collections in monastery libraries

Directory of Open Access Journals (Sweden)

Maja Krtalić

2012-02-01

Full Text Available The aim of the paper is to investigate the preservation of written heritage in monastery libraries from legislative, institutional and organizational perspectives, and establish the necessary organizational prerequisites for improvement. Setting off from the presupposition that the library collections of monastery libraries are of immense cultural value, and can therefore be considered cultural good and part of Croatian written heritage, the paper discussed the need for a systematic approach to its protection, both on the operative level, in libraries themselves, and on the strategic level, by the authorities and other relevant institutions in the Republic of Croatia. In addition to the analysis of the legal and institutional frameworks and library collections preservation projects, three case studies were conducted in Franciscan monasteries in Mostar, Požega and Zadar, including interviews with their managers and one subject from the Croatian Institute of Librarianship. The case study aimed to investigate the context of the preservation of library collections in monastery libraries and provide answers to the following questions: how is the preservation in monastery libraries defined; how does it differ from the preservation in other libraries, and how is the preservation of collections in these libraries organized on institutional, local, and national levels? The research sets off from several core presuppositions: monastery libraries have valuable collections of Croatian and European written heritage; the heritage collections in monastery libraries are not investigated, organized, protected or presented at an adequate level; the responsibility for its preservation is not clearly assigned, there is not enough staff trained for preservation; the improvements in preservation and availability of library collections in monastery libraries should result from a better organization and management of the heritage preservation system in monastery

Library 2.0 A New Service Model For Libraries

Directory of Open Access Journals (Sweden)

Agnes Erich

2007-01-01

Full Text Available The utilization of the new information and communication technologies implies a series of changes concerning the libraries. Currently it is spoken more and more about a new type of service offered by them, Library 2.0, which brings in foreground the user who becomes a modeler of the library services and resources. The information structures customer is not satisfied anymore by the unidirectional access to the resources, he wanted to be involved in the evaluation of them, making comments and sharing his ideas with another user. In this sense the library managers are looking for more efficient means to deliver services so that to obtain a proper feedback which enable them to take the best measures to make profitable them. Library 2.0 can be a solution for all these problems.

Recombinant Polyclonal Antibody Libraries for Breast Cancer Therapy

National Research Council Canada - National Science Library

Sharon, Jacqueline

1999-01-01

.... In the present study, V region genes for construction of a polyclonal Fab phage display library were obtained from the spleen, bone marrow, and intestine of a BALB/c mouse that had been immunized with BT-20 cells...

The Development of National Library Functions in the British Museum Library and the Library of Congress.

Science.gov (United States)

Stewart, Richard Addison

The histories of two national libraries, the British Museum Library and the Library of Congress, are examined with respect to the development of each of three functions: (1) the acquisition and maintenance of a comprehensive collection of the country's publications, usually by copyright deposit; (2) the maintenance of basic research collections in…

Use of library statistics to support library and advisory services and ...

African Journals Online (AJOL)

Statistical information is a vital tool for management and development of organizations. Keeping statistics of activities is basic to the survival and progress of a library and enables the library to measure its performance periodically. The National Library of Nigeria (NLN) places high premium on the library statistics that it ...

Is Your Academic Library Pinning? Academic Libraries and Pinterest

Science.gov (United States)

Thornton, Elaine

2012-01-01

Academic libraries are flocking to online social networking sites in an effort to meet users where they are. Pinterest is the latest of these rapidly growing online social networking tools. The author of this article reports results from a survey on academic libraries' presence on Pinterest. The survey found most academic library pinboards are in…

There is a Lack of Standardization in the Collection Development and Circulation Policies of Prison Library Services. A Review of: Conrad, S. (2012. Collection development and circulation policies in prison libraries: An exploratory survey of librarians in US correctional institutions. The Library Quarterly, 82(4, 407-427.

Directory of Open Access Journals (Sweden)

Michelle Dalton

2013-06-01

Full Text Available Objective – To explore how collection development policies currently support the role and purpose of prison libraries, and to explore if the accessibility of circulation records impacts on patron privacy.Design – Online survey questionnaire and a case study analysis of the existing policy statements of selected correctional institutions.Setting – The prison library sector in the United States.Subjects – 17 librarians and library staff across ten states in the United States.Methods – An eight-question online questionnaire was used to explore the existing collection development and circulation policies in prison libraries, and the level of adherence to the guidelines of the Association of Specialized and Cooperative Library Agencies (ASCLA and the American Correctional Association (ACA. In addition, participants were encouraged to forward any circulation or collection development policy statements for more detailed analysis. Each policy was then reviewed to assess the degree of alignment or otherwise with the American Library Association’s (ALA Prisoners’ Right to Read guidelines (2010.Main Results – The results of the survey found that 24% of libraries had no formal collection development policy, and at least 53% of libraries had no circulation policy statement. In these instances, the libraries were typically subject to the local policies and procedures of the correctional institution. The purpose of the library and its collection was primarily viewed as: providing recreational reading material; maintaining contact with the outside world and enabling re-entry into the community; and supporting vocational skills and lifelong learning. In selecting materials, the results indicated that a broadly similar approach to that of public libraries was adopted by most institutions, with the exception of any material that may pose a safety or security threat to the institution. In one institution the use of library services or resources for

Library/vendor relationships

CERN Document Server

Brooks, Sam

2014-01-01

A view of the mutual dependence between libraries and vendorsAs technology advances, libraries are forced to reach beyond their own resources to find effective ways to maintain accuracy and superior service levels. Vendors provide databases and integrated library systems that perform those functions for profit. Library/Vendor Relationships examines the increasing cooperation in which libraries find they must participate in, and vice versa, with the vendors that provide system infrastructure and software. Expert contributors provide insights from all sides of this unique collaboration, offering

The Analysis Condition of Special Library for Street Children at UPTD "Kampung Anak Negeri” Institutions

Directory of Open Access Journals (Sweden)

Fitri Mutia

2016-12-01

Full Text Available The existence of special library UPTD the "Kampung Anak Negeri" became one medium that can be used to develop the potential of street children themselves a growing number from year to year. This study conducted descriptive quantitative research that aim to describe the condition of special libraries in UPTD “Kampung Anak Negeri", especially in terms of collections, facilities and infrastructure, library services and human resources (librarian. The four aspects are then compared with the standard of the special library collated by the National Library in 2011. In this study, data collection technique conducted in July 2016 using interview techniques as a primary technique performed on librarians and include interviews with street children as well as staff of Colleagues   staff UPTD.  Based on the data obtained can be concluded that the amount of the book collection of about 752 titles of books, collection development has not reached 5% per year, spacious room just 35m² and has only 2 rack collection. Services available are services in place read, circulation services and information search services, while the librarians who manage only one person with a background in library and information science education. In general, special libraries UPTD condition does not meet the standard, so this affects is not maximized to support learning process as well as in facilities that match the information needs of street children.

Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions.

Science.gov (United States)

Naumer, Matthias; Ying, Ying; Michelfelder, Stefan; Reuter, Antje; Trepel, Martin; Müller, Oliver J; Kleinschmidt, Jürgen A

2012-05-01

Libraries based on the insertion of random peptide ligands into the capsid of adeno-associated virus type 2 (AAV2) have been widely used to improve the efficiency and selectivity of the AAV vector system. However, so far only libraries of 7-mer peptide ligands have been inserted at one well-characterized capsid position. Here, we expanded the combinatorial AAV2 display system to a panel of novel AAV libraries, displaying peptides of 5, 7, 12, 19, or 26 amino acids in length at capsid position 588 or displaying 7-mer peptides at position 453, the most prominently exposed region of the viral capsid. Library selections on two unrelated cell types-human coronary artery endothelial cells and rat cardiomyoblasts-revealed the isolation of cell type-characteristic peptides of different lengths mediating strongly improved target-cell transduction, except for the 26-mer peptide ligands. Characterization of vector selectivity by transduction of nontarget cells and comparative gene-transduction analysis using a panel of 44 human tumor cell lines revealed that insertion of different-length peptides allows targeting of distinct cellular receptors for cell entry with similar efficiency, but with different selectivity. The application of such novel AAV2 libraries broadens the spectrum of targetable receptors by capsid-modified AAV vectors and provides the opportunity to choose the best suited targeting ligand for a certain application from a number of different candidates.

Environmental Control for Regional Library Facilities. RR-80-3.

Science.gov (United States)

King, Richard G., Jr.

This report presents an overview of the damage to library materials caused by uncontrollable environmental variables. The control of atmospheric pollutants, temperature, and humidity are discussed with regard to damage, standards, and the costs of deterioration due to these factors. Twelve references are listed. (FM)

Curatr: a web application for creating, curating and sharing a mass spectral library.

Science.gov (United States)

Palmer, Andrew; Phapale, Prasad; Fay, Dominik; Alexandrov, Theodore

2018-04-15

We have developed a web application curatr for the rapid generation of high quality mass spectral fragmentation libraries from liquid-chromatography mass spectrometry datasets. Curatr handles datasets from single or multiplexed standards and extracts chromatographic profiles and potential fragmentation spectra for multiple adducts. An intuitive interface helps users to select high quality spectra that are stored along with searchable molecular information, the providence of each standard and experimental metadata. Curatr supports exports to several standard formats for use with third party software or submission to repositories. We demonstrate the use of curatr to generate the EMBL Metabolomics Core Facility spectral library http://curatr.mcf.embl.de. Source code and example data are at http://github.com/alexandrovteam/curatr/. palmer@embl.de. Supplementary data are available at Bioinformatics online.

Teleporting the library?

DEFF Research Database (Denmark)

Heilesen, Simon

2009-01-01

In 2007, six Danish public libraries established a virtual library, Info Island DK, in Second Life. This article discusses the library project in terms of design. The design processes include the planning and implementation of the virtual library structure and its equipment, as well...... as the organizing and carrying out of activities in the virtual setting. It will be argued that, to a large extent, conventions have determined design and use of the virtual library, and also that design has had an impact on the attitudes and understanding of the participants....

Mapping the Association of College and Research Libraries information literacy framework and nursing professional standards onto an assessment rubric.

Science.gov (United States)

Willson, Gloria; Angell, Katelyn

2017-04-01

The authors developed a rubric for assessing undergraduate nursing research papers for information literacy skills critical to their development as researchers and health professionals. We developed a rubric mapping six American Nurses Association professional standards onto six related concepts of the Association of College & Research Libraries (ACRL) Framework for Information Literacy for Higher Education. We used this rubric to evaluate fifty student research papers and assess inter-rater reliability. Students tended to score highest on the "Information Has Value" dimension and lowest on the "Scholarship as Conversation" dimension. However, we found a discrepancy between the grading patterns of the two investigators, with inter-rater reliability being "fair" or "poor" for all six rubric dimensions. The development of a rubric that dually assesses information literacy skills and maps relevant disciplinary competencies holds potential. This study offers a template for a rubric inspired by the ACRL Framework and outside professional standards. However, the overall low inter-rater reliability demands further calibration of the rubric. Following additional norming, this rubric can be used to help students identify the key information literacy competencies that they need in order to succeed as college students and future nurses. These skills include developing an authoritative voice, determining the scope of their information needs, and understanding the ramifications of their information choices.

Public Libraries in Bangladesh.

Science.gov (United States)

Khan, M. H.

1984-01-01

Overview of library movement in Bangladesh highlights British (1851-1947) and Pakistan periods (1947-1971), separation of Bangladesh from Pakistan, libraries in development plans (1951-1970), three important public libraries, development of national library, book resources, a library network plan, legislation, finance, leadership, library…

Proceedings of a Conference on Telecommunication Technologies, Networkings and Libraries

Science.gov (United States)

Knight, N. K.

1981-12-01

Current and developing technologies for digital transmission of image data likely to have an impact on the operations of libraries and information centers or provide support for information networking are reviewed. Technologies reviewed include slow scan television, teleconferencing, and videodisc technology and standards development for computer network interconnection through hardware and software, particularly packet switched networks computer network protocols for library and information service applications, the structure of a national bibliographic telecommunications network; and the major policy issues involved in the regulation or deregulation of the common communications carriers industry.

Library system of Italy

Directory of Open Access Journals (Sweden)

Nataša Gerbec

2003-01-01

Full Text Available In the European extent, Italy is the cradle of libraries and library sciences. In the past, Italian national public libraries played an important role through their vast book treasury. But only during the last thirty years have public libraries been developed following the Anglo-American public library model. Italy does not have any uniform or general legislation concerning libraries. On the state level, this area is regulated by some separate acts, while on the regional level there is a collection of various acts and regulations. Libraries are not strictly divided into general categories. It is required that the professionals engaged in Italian libraries should have secondary or university education. The level of their professional tasks depends on the type of library and its capacity. The competency for the development in the field of librarianship is assigned to The Ministry of Cultural and Environment Heritage as well as to its subordinate institutions (Central Institute for the Union catalogue of Italian Libraries and for Bibliographic Information, Central Institute for Book Pathology, Observatory for International Libraries Programmes.

The library catalogue as a retrieval tool in academic libraries: a case ...

African Journals Online (AJOL)

The library catalogue as a retrieval tool in academic libraries: a case study of federal university of technology Owerri library. ... Information Technologist (The) ... be emphasized and made compulsory for a ll library users and strengthening the ...

News from the Library

CERN Multimedia

CERN Library

2010-01-01

The LHC Library to be merged with the Central Library. Not everyone knows that CERN Scientific Information Service currently counts three physical libraries on site. The Central Library is located in Building 52 and there are two satellite libraries located respectively in building 30 (the LHC Library) and in building 864 on Prévessin site (the SPS Library). Moreover, the Legal Service Library is located in Building 60. In the past, there have been at CERN up to 6 satellite libraries; they were essential at a time when information was only in paper form and having multiple copies of documents located in several places at CERN was useful to facilitate scientific research. Today, this need is less critical as most of our resources are online. That is why, following a SIPB (Scientific Information Policy Board) decision, the collections of the LHC Library will be merged this summer with the Central collection. This reorganization and centralization of resources will improve loan services. The SP...

A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells

Science.gov (United States)

Magness, Scott T.; Puthoff, Brent J.; Crissey, Mary Ann; Dunn, James; Henning, Susan J.; Houchen, Courtney; Kaddis, John S.; Kuo, Calvin J.; Li, Linheng; Lynch, John; Martin, Martin G.; May, Randal; Niland, Joyce C.; Olack, Barbara; Qian, Dajun; Stelzner, Matthias; Swain, John R.; Wang, Fengchao; Wang, Jiafang; Wang, Xinwei; Yan, Kelley; Yu, Jian

2013-01-01

Fluorescence-activated cell sorting (FACS) is an essential tool for studies requiring isolation of distinct intestinal epithelial cell populations. Inconsistent or lack of reporting of the critical parameters associated with FACS methodologies has complicated interpretation, comparison, and reproduction of important findings. To address this problem a comprehensive multicenter study was designed to develop guidelines that limit experimental and data reporting variability and provide a foundation for accurate comparison of data between studies. Common methodologies and data reporting protocols for tissue dissociation, cell yield, cell viability, FACS, and postsort purity were established. Seven centers tested the standardized methods by FACS-isolating a specific crypt-based epithelial population (EpCAM+/CD44+) from murine small intestine. Genetic biomarkers for stem/progenitor (Lgr5 and Atoh 1) and differentiated cell lineages (lysozyme, mucin2, chromogranin A, and sucrase isomaltase) were interrogated in target and control populations to assess intra- and intercenter variability. Wilcoxon's rank sum test on gene expression levels showed limited intracenter variability between biological replicates. Principal component analysis demonstrated significant intercenter reproducibility among four centers. Analysis of data collected by standardized cell isolation methods and data reporting requirements readily identified methodological problems, indicating that standard reporting parameters facilitate post hoc error identification. These results indicate that the complexity of FACS isolation of target intestinal epithelial populations can be highly reproducible between biological replicates and different institutions by adherence to common cell isolation methods and FACS gating strategies. This study can be considered a foundation for continued method development and a starting point for investigators that are developing cell isolation expertise to study physiology and

LibCPIXE: A PIXE simulation open-source library for multilayered samples

International Nuclear Information System (INIS)

Pascual-Izarra, C.; Barradas, N.P.; Reis, M.A.

2006-01-01

Most particle induced X-ray emission (PIXE) data analysis codes are not focused on handling multilayered samples. We have developed an open-source library called 'LibCPIXE', for PIXE data analysis. It is written in standard C and implements functions for simulating X-ray yields of PIXE spectra taken from arbitrary samples, including multilayered targets. The library is designed to be fast, portable, modular and scalable, as well as to facilitate its incorporation into any existing program. In order to demonstrate the capabilities of the library, a program called CPIXE was developed and used to analyze various real samples involving both bulk and layered samples. Just as the library, the CPIXE source code is freely available under the General Public License. We demonstrate that it runs both under GNU/Linux systems as well as under MS Windows. There is in principle no limitation to port it to other platforms

Effects of nuclear data library on BFS and ZPPR fast reactor core analysis results. Pt. 2. BFS-62 analysis results

International Nuclear Information System (INIS)

Mantourov, Guennadi

2001-11-01

This work was fulfilled in the frame of JNC-IPPE Collaboration on Experimental Investigation of Excess Weapon Pu Disposition in BN-600 Reactor Using BFS-2 Facility. Data processing system CONSYST/ABBN coupled with ABBN-93 nuclear data library was used in analysis of BFS-62 and ZPPR JUPIER series fast reactor cores, applying JNC core calculation code CITATION-FBR. FFCP cell code was used for taking into account the spatial cell heterogeneity and resonance effects based on the First Flight Collision Probability method and subgroup approach. Especially, two converting programs were written to transmit the prepared effective cross sections to JNC standard PDS files to let then the CITATION code be applied for 3-D HEXZ neutronics calculations of the investigated cores. The effects of nuclear data library have been studied by comparing the results calculated using ABBN-93 nuclear data library with the former ones obtained in JNC based on JENDL-3.2 nuclear data library. The comparison results using IPPE and JNC nuclear data libraries for k-effective parameter for 4 BFS-62 cores as well as for 3 ZPPR JUPITER experiment series cores ZPPR-9, ZPPR-13A and ZPPR-17A are presented. The comparison results for reaction rates distributions for 2 BFS-62 uranium loaded cores are included too. The calculated correction factors applied in all cases were less than 1.0%. The estimated uncertainty in k-effective C values caused by possible errors in calculation of the applied corrections is about 0.3% in case of BFS-62 and ZPPR MOX cores, and is about 0.2% for BFS-62 uranium-loaded cores. The main result of this study is that the effect of applying ABBN-93 nuclear data in JNC's calculation route for k-effective results is about 0.3% for ZPPR and BFS-62 cores with plutonium. As for BFS uranium-loaded cores (BFS-62-1 and BFS-62-2) the nuclear data library effect is about 0.1%. Next the sensitivity analysis was applied. It shown that the main contributors to the nuclear data library effect

Evaluation of academic library collection using a check-list method

Directory of Open Access Journals (Sweden)

Kornelija Petr Balog

2015-04-01

Full Text Available The purpose of this paper is to evaluate the quality of the ILS library collection of the Faculty of Humanities and Social Sciences (FHSS in Osijek, Croatia and its congruence with the curriculum. The quality of the collection is measured using the check-list method. The required and optional reading lists of the Department of Information Sciences at the FHSS (academic year 2011/2012 are used as standard lists that the library holdings are compared to. The results found that the library does not have 30.8 per cent of the titles on the reading lists. The remaining 33.9 per cent of the titles are accessible in the library, 28.5 per cent are free electronic resources, and 6.8 per cent of titles are accessible for students through the Department’s Moodle, Learning Management System. The study provides data about the titles available and not available in the FHSS library. However, it does not differentiate between the titles on the required and optional reading lists. This study provides the FHSS librarians with the list of titles that should be obtained in the near future. In Croatia, very few papers on collection assessment have been published so far, and this is the first study about the quality of a library collection at the University of Osijek. The paper attempts to fill that gap and contribute to a deeper understanding of the quality of library collections in the Croatian academic setting.

Learning Commons in Academic Libraries: Discussing Themes in the Literature from 2001 to the Present

Science.gov (United States)

Blummer, Barbara; Kenton, Jeffrey M.

2017-01-01

Although the term lacks a standard definition, learning commons represent academic library spaces that provide computer and library resources as well as a range of academic services that support learners and learning. Learning commons have been equated to a laboratory for creating knowledge and staffed with librarians that serve as facilitators of…

Library Research and Statistics. Research on Libraries and Librarianship in 2002; Number of Libraries in the United States and Canada; Highlights of NCES Surveys; Library Acquisition Expenditures, 2001-2002: U.S. Public, Academic, Special, and Government Libraries; LJ Budget Report: A Precarious Holding Pattern; Price Indexes for Public and Academic Libraries; Library Buildings 2002: The Building Buck Doesn't Stop Here.

Science.gov (United States)

Lynch, Mary Jo; Oder, Norman; Halstead, Kent; Fox, Bette-Lee

2003-01-01

Includes seven reports that discuss research on libraries and librarianship, including academic, public, and school libraries; awards and grants; number of libraries in the United States and Canada; National Center for Education Statistics results; library expenditures for public, academic, special, and government libraries; library budgets; price…

Library design practices for success in lead generation with small molecule libraries.

Science.gov (United States)

Goodnow, R A; Guba, W; Haap, W

2003-11-01

The generation of novel structures amenable to rapid and efficient lead optimization comprises an emerging strategy for success in modern drug discovery. Small molecule libraries of sufficient size and diversity to increase the chances of discovery of novel structures make the high throughput synthesis approach the method of choice for lead generation. Despite an industry trend for smaller, more focused libraries, the need to generate novel lead structures makes larger libraries a necessary strategy. For libraries of a several thousand or more members, solid phase synthesis approaches are the most suitable. While the technology and chemistry necessary for small molecule library synthesis continue to advance, success in lead generation requires rigorous consideration in the library design process to ensure the synthesis of molecules possessing the proper characteristics for subsequent lead optimization. Without proper selection of library templates and building blocks, solid phase synthesis methods often generate molecules which are too heavy, too lipophilic and too complex to be useful for lead optimization. The appropriate filtering of virtual library designs with multiple computational tools allows the generation of information-rich libraries within a drug-like molecular property space. An understanding of the hit-to-lead process provides a practical guide to molecular design characteristics. Examples of leads generated from library approaches also provide a benchmarking of successes as well as aspects for continued development of library design practices.

Chat reference service in medical libraries: part 2--Trends in medical school libraries.

Science.gov (United States)

Dee, Cheryl R

2003-01-01

An increasing number of medical school libraries offer chat service to provide immediate, high quality information at the time and point of need to students, faculty, staff, and health care professionals. Part 2 of Chat Reference Service in Medical Libraries presents a snapshot of the current trends in chat reference service in medical school libraries. In late 2002, 25 (21%) medical school libraries provided chat reference. Trends in chat reference services in medical school libraries were compiled from an exploration of medical school library Web sites and informal correspondence from medical school library personnel. Many medical libraries are actively investigating and planning new chat reference services, while others have decided not to pursue chat reference at this time. Anecdotal comments from medical school library staff provide insights into chat reference service.

Library Dream Machines: Helping Students Master Super Online Catalogs.

Science.gov (United States)

Webb, T. D.

1992-01-01

Describes how automation has transformed the library and how super-catalogs have affected the process of doing research. Explains how faculty and librarians can work together to help students to use the available databases effectively, by teaching them Boolean logic, standard record formats, filing rules, etc. (DMM)

Fluorous Parallel Synthesis of A Hydantoin/Thiohydantoin Library

Science.gov (United States)

Lu, Yimin; Zhang, Wei

2007-01-01

Fluorous tagging strategy is applied to solution-phase parallel synthesis of a library containing hydantoin and thiohydantoin analogs. Two perfluoroalkyl (Rf)-tagged α-amino esters each react with 6 aromatic aldehydes under reductive amination conditions. Twelve amino esters then each react with 10 isocyanates and isothiocyanates in parallel. The resulting 120 ureas and thioureas undergo spontaneous cyclization to form the corresponding hydantoins and thiohydantoins. The intermediate and final product purifications are performed with solid-phase extraction (SPE) over FluoroFlash™ cartridges, no chromatography is required. Using standard instruments and straightforward SPE technique, one chemist accomplished the 120-member library synthesis in less than 5 working days, including starting material synthesis and product analysis. PMID:15789556

ORIGEN-S data libraries

International Nuclear Information System (INIS)

Ryman, J.C.

1984-01-01

There are five card-image nuclear data libraries: (1) a small light element library for 253 nuclides, (2) a large light element library for 687 nuclides, (3) an actinide library for 101 nuclides, (4) a small fission product library for 461 nuclides, and (5) a large fission product library for 821 nuclides. The data for each nuclide are contained on five card-image records. The first card image contains decay data (half-life, branching fractions, recoverable energy per decay and the fraction of recoverable energy from photons), percent natural abundance, and radioactivity concentration guides. The last four card images contain cross section and (for fission product nuclides) fission yield data for four reactor types (HTGR, LWR, LMFBR, and MSBR), with one card for each reactor type. The card-image nuclear data libraries are the basic libraries for ORIGEN-S. The code can be run using these libraries directly, or it can be run from a binary data library which (prior to any cross section or other nuclear data updating) was created by running the COUPLE code to convert one or more of these card-image libraries

Main Libraries, Branches, and Bookmobiles: FY 2013 Public Libraries Survey (Outlet)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on main libraries, branches, and bookmobiles, including FSCS IDs and location.These data include imputed values for libraries that did not...

Afghanistan Digital Library Initiative: Revitalizing an Integrated Library System

Directory of Open Access Journals (Sweden)

Yan HAN

2007-12-01

Full Text Available This paper describes an Afghanistan digital library initiative of building an integrated library system (ILS for Afghanistan universities and colleges based on open-source software. As one of the goals of the Afghan eQuality Digital Libraries Alliance, the authors applied systems analysis approach, evaluated different open-source ILSs, and customized the selected software to accommodate users’ needs. Improvements include Arabic and Persian language support, user interface changes, call number label printing, and ISBN-13 support. To our knowledge, this ILS is the first at a large academic library running on open-source software.

Presentation of the selected French libraries and the French library system

Directory of Open Access Journals (Sweden)

Moja Kotar

2007-01-01

Full Text Available The Selected French libraries (Bibliotheque nationale de France, Bibliotheque publique d’information, multimedia library of the Cité des sciences et de l’industrie as well as Paris public libraries are presented in the article. France does not have a union catalogue at the national level, therefore libraries use different platforms for shared cataloguing and compile more union catalogues. According to their needs, French libraries join into consortia for the acquisition of electronic resources, which can be either geographically or thematically delimited or formed by the institutions of the same status. The author believes that the Slovenian library network works well considering much smaller budget for culture and higher education in comparison with France. To improve its performance, more funds would have to be allocated and higher reputation of the library profession achieved, comparable to the situation in France. Digitization of resources is the area where the Slovenian librarianship lags most behind the French one.

Keeping Current: Emotional Intelligence and the School Library Media Specialist.

Science.gov (United States)

Barron, Daniel D.

1997-01-01

Discusses emotional intelligence and its importance for school library media specialists, based on a book by Daniel Goleman called "Emotional Intelligence." Highlights include managing emotions and relationships; self-motivation; and how emotional intelligence fits in with Standards for Information Literacy. (LRW)

Assessment of Library Instruction and Library Literacy Skills of First ...

African Journals Online (AJOL)

This study investigated the effectiveness and impact of library instruction (GST 111 – the use of library) course on library literacy skills of first year undergraduate students. The study adopted the descriptive survey research method and questionnaire was used as the research instrument. First year undergraduate students of ...

Student Library Pages: Valuable Resource for the Library Media Center.

Science.gov (United States)

Crowther, Eleanor

1993-01-01

Describes the use of students as library pages at the Loudoun Country Day School (Virginia). Highlights include student selection procedures, including interviews; parental consent form; library page duties; benefits to students; benefits to the library; and parent attitudes. Copies of the student interview form and parental consent form are…

Using a Google Search Appliance (GSA) to search digital library collections: a case study of the INIS Collection Search

OpenAIRE

Savic, Dobrica

2014-01-01

Libraries are facing many challenges today. In addition to diminishing funding and increased user expectations, the use of classic library catalogues is becoming an additional challenge. Library users require fast and easy access to information resources regardless whether the format used is paper or electronic. Google search, with its speed and simplicity, set up a new standard for information retrieval which is hard to achieve with the previous generation of library search facilities. Put i...

Smart Objects, Dumb Archives: A User-Centric, Layered Digital Library Framework

Science.gov (United States)

Maly, Kurt; Nelson, Michael L.; Zubair, Mohammad

1999-01-01

Currently, there exist a large number of superb digital libraries, all of which are, unfortunately, vertically integrated and all presenting a monolithic interface to their users. Ideally, a user would want to locate resources from a variety of digital libraries dealing only with one interface. A number of approaches exist to this interoperability issue exist including: defining a universal protocol for all libraries to adhere to; or developing mechanisms to translate between protocols. The approach we illustrate in this paper is to push down the level of universal protocols to one for digital object communication and for communication for simple archives. This approach creates the opportunity for digital library service providers to create digital libraries tailored to the needs of user communities drawing from available archives and individual publishers who adhere to this standard. We have created a reference implementation based on the hyper text transfer protocol (http) with the protocols being derived from the Dienst protocol. We have created a special class of digital objects called buckets and a number of archives based on a NASA collection and NSF funded projects. Starting from NCSTRL we have developed a set of digital library services called NCSTRL+ and have created digital libraries for researchers, educators and students that can each draw on all the archives and individually created buckets.

New evaluated neutron cross section libraries for the GEANT4 code

International Nuclear Information System (INIS)

Mendoza, E.; Cano-Ott, D.; Guerrero, C.; Capote, R.

2012-04-01

The so-called High Precision neutron physics model implemented in the GEANT4 simulation package allows simulating the transport of neutrons with energies up to 20 MeV. It relies on the G4NDL cross section libraries, prepared by the GEANT4 collaboration from evaluated cross section files and distributed freely together with the code. Even though the performance of the G4NDL library has been improved over the time, users running complex simulations which involve the transport of neutrons do need more flexibility, in particular when assessing the uncertainties in the simulation results due to the neutron (and hence the nuclear) data library used. For this reason, a software tool has been developed for transforming any evaluated neutron cross section library in the ENDF-6 format into the G4NDL format. Furthermore, eight different releases of ENDF-B, JEFF, JENDL, CENDL and BROND national libraries have been translated into the G4NDL format and are distributed by the IAEA nuclear data service at www-nds.iaea.org/geant4. In this way, GEANT4 users have access to the complete list of standard evaluated neutron data libraries when performing Monte Carlo simulations with GEANT4. Consistency checks and a first validation of the libraries have been made following the methods described in this report. (author)

The Value of Nonmedical Academic Libraries to Medical Libraries: A Case in Point

Science.gov (United States)

Drake, Paul B.

2010-01-01

While the National Library of Medicine created the National Network of Libraries of Medicine (NN/LM) as a network to provide medical and health information, historically few nonmedical academic libraries have participated. University medical libraries and hospital libraries have been the major focus of the Network. Recently, the NNLM has…

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Science.gov (United States)

Keenan, Alexandra B; Jenkins, Sherry L; Jagodnik, Kathleen M; Koplev, Simon; He, Edward; Torre, Denis; Wang, Zichen; Dohlman, Anders B; Silverstein, Moshe C; Lachmann, Alexander; Kuleshov, Maxim V; Ma'ayan, Avi; Stathias, Vasileios; Terryn, Raymond; Cooper, Daniel; Forlin, Michele; Koleti, Amar; Vidovic, Dusica; Chung, Caty; Schürer, Stephan C; Vasiliauskas, Jouzas; Pilarczyk, Marcin; Shamsaei, Behrouz; Fazel, Mehdi; Ren, Yan; Niu, Wen; Clark, Nicholas A; White, Shana; Mahi, Naim; Zhang, Lixia; Kouril, Michal; Reichard, John F; Sivaganesan, Siva; Medvedovic, Mario; Meller, Jaroslaw; Koch, Rick J; Birtwistle, Marc R; Iyengar, Ravi; Sobie, Eric A; Azeloglu, Evren U; Kaye, Julia; Osterloh, Jeannette; Haston, Kelly; Kalra, Jaslin; Finkbiener, Steve; Li, Jonathan; Milani, Pamela; Adam, Miriam; Escalante-Chong, Renan; Sachs, Karen; Lenail, Alex; Ramamoorthy, Divya; Fraenkel, Ernest; Daigle, Gavin; Hussain, Uzma; Coye, Alyssa; Rothstein, Jeffrey; Sareen, Dhruv; Ornelas, Loren; Banuelos, Maria; Mandefro, Berhan; Ho, Ritchie; Svendsen, Clive N; Lim, Ryan G; Stocksdale, Jennifer; Casale, Malcolm S; Thompson, Terri G; Wu, Jie; Thompson, Leslie M; Dardov, Victoria; Venkatraman, Vidya; Matlock, Andrea; Van Eyk, Jennifer E; Jaffe, Jacob D; Papanastasiou, Malvina; Subramanian, Aravind; Golub, Todd R; Erickson, Sean D; Fallahi-Sichani, Mohammad; Hafner, Marc; Gray, Nathanael S; Lin, Jia-Ren; Mills, Caitlin E; Muhlich, Jeremy L; Niepel, Mario; Shamu, Caroline E; Williams, Elizabeth H; Wrobel, David; Sorger, Peter K; Heiser, Laura M; Gray, Joe W; Korkola, James E; Mills, Gordon B; LaBarge, Mark; Feiler, Heidi S; Dane, Mark A; Bucher, Elmar; Nederlof, Michel; Sudar, Damir; Gross, Sean; Kilburn, David F; Smith, Rebecca; Devlin, Kaylyn; Margolis, Ron; Derr, Leslie; Lee, Albert; Pillai, Ajay

2018-01-24

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability. Copyright © 2017 Elsevier Inc. All rights reserved.

Marketing the Virtual Library

Science.gov (United States)

Fagan, Jody Condit

2009-01-01

Far more people are familiar with their local public or college library facility than their library's website and online resources. In fact, according to a recent survey, 96% of Americans said they had visited a library in person, but less than one-third have visited their online library. Since everyone agrees that online library resources are…

Comparison of Standard Light Water Reactor Cross-Section Libraries using the United States Nuclear Regulatory Commission Boiling Water Reactor Benchmark Problem

Directory of Open Access Journals (Sweden)

Kulesza Joel A.

2016-01-01

Full Text Available This paper describes a comparison of contemporary and historical light water reactor shielding and pressure vessel dosimetry cross-section libraries for a boiling water reactor calculational benchmark problem. The calculational benchmark problem was developed at Brookhaven National Laboratory by the request of the U. S. Nuclear Regulatory Commission. The benchmark problem was originally evaluated by Brookhaven National Laboratory using the Oak Ridge National Laboratory discrete ordinates code DORT and the BUGLE-93 cross-section library. In this paper, the Westinghouse RAPTOR-M3G three-dimensional discrete ordinates code was used. A variety of cross-section libraries were used with RAPTOR-M3G including the BUGLE93, BUGLE-96, and BUGLE-B7 cross-section libraries developed at Oak Ridge National Laboratory and ALPAN-VII.0 developed at Westinghouse. In comparing the calculated fast reaction rates using the four aforementioned cross-section libraries in the pressure vessel capsule, for six dosimetry reaction rates, a maximum relative difference of 8% was observed. As such, it is concluded that the results calculated by RAPTOR-M3G are consistent with the benchmark and further that the different vintage BUGLE cross-section libraries investigated are largely self-consistent.

Construction of high-quality Caco-2 three-frame cDNA library and its application to yeast two-hybrid for the human astrovirus protein-protein interaction.

Science.gov (United States)

Zhao, Wei; Li, Xin; Liu, Wen-Hui; Zhao, Jian; Jin, Yi-Ming; Sui, Ting-Ting

2014-09-01

Human epithelial colorectal adenocarcinoma (Caco-2) cells are widely used as an in vitro model of the human small intestinal mucosa. Caco-2 cells are host cells of the human astrovirus (HAstV) and other enteroviruses. High quality cDNA libraries are pertinent resources and critical tools for protein-protein interaction research, but are currently unavailable for Caco-2 cells. To construct a three-open reading frame, full length-expression cDNA library from the Caco-2 cell line for application to HAstV protein-protein interaction screening, total RNA was extracted from Caco-2 cells. The switching mechanism at the 5' end of the RNA transcript technique was used for cDNA synthesis. Double-stranded cDNA was digested by Sfi I and ligated to reconstruct a pGADT7-Sfi I three-frame vector. The ligation mixture was transformed into Escherichia coli HST08 premium electro cells by electroporation to construct the primary cDNA library. The library capacity was 1.0×10(6)clones. Gel electrophoresis results indicated that the fragments ranged from 0.5kb to 4.2kb. Randomly picked clones show that the recombination rate was 100%. The three-frame primary cDNA library plasmid mixture (5×10(5)cfu) was also transformed into E. coli HST08 premium electro cells, and all clones were harvested to amplify the cDNA library. To detect the sufficiency of the cDNA library, HAstV capsid protein as bait was screened and tested against the Caco-2 cDNA library by a yeast two-hybrid (Y2H) system. A total of 20 proteins were found to interact with the capsid protein. These results showed that a high-quality three-frame cDNA library from Caco-2 cells was successfully constructed. This library was efficient for the application to the Y2H system, and could be used for future research. Copyright © 2014 Elsevier B.V. All rights reserved.

Library Systems: FY 1992-2012 Public Libraries Survey Trends (Administrative Entity)

Data.gov (United States)

Institute of Museum and Library Services — Find key information on trends in library systems around the United States from FY 1992 to FY 2012.These data include imputed values for libraries that did not...

FENDL multigroup libraries

International Nuclear Information System (INIS)

Ganesan, S.; Muir, D.W.

1992-01-01

Selected neutron reaction nuclear data libraries and photon-atomic interaction cross section libraries for elements of interest to the IAEA's program on Fusion Evaluated Nuclear Data Library (FENDL) have been processed into MATXSR format using the NJOY system on the VAX4000 computer of the IAEA. This document lists the resulting multigroup data libraries. All the multigroup data generated are available cost-free upon request from the IAEA Nuclear Data Section. (author). 9 refs

The WIMSLIB library - neutron data library for WIMS-D

International Nuclear Information System (INIS)

Liu Ping

1998-05-01

During a visit to the IAEA Nuclear Data Section from 13 June to 12 December 1997, the author processed the Chinese Evaluated Nuclear Data Library (CENDL), Version 2.1, using the NJOY Nuclear Data Processing System, Version 94.105, to generate the working library WIMSLIB for input to WIMS-D/4 and WIMS-D/5A. The WIMSLIB library was then used to perform benchmark testing of CENDL-2.1. (author)

Leadership In The Public Library : Case Study In Tenteram City Public Library

Directory of Open Access Journals (Sweden)

Muhammad Irsyad Al Fatih

2018-01-01

Full Text Available In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader. The Leader of an organization is expected to have leadership qualities, which showed his skills in leading organizations. A leader in the library requires synergy between skills in library management and leadership in general in order to create a good working atmosphere and to encourage the library staff in providing the best services to the patron community. Tenteram City Public library since year of 2018 has never experienced a change of its leader. Research using qualitative approach aimed to identify the leadership of Tenteram City public library leader in developing human resources and library services. Data of this study is gathered through observation and interviews. It is found that the head of the library serves as a role model in imbedding working discipline, he never involved the staff in decision making, the fear of making mistake is the working atmosphere created in the library. The Research found that the head of Tenteram City public library adopts autocratic leadership.

Leadership In The Public Library : Case Study In Tenteram City Public Library

Directory of Open Access Journals (Sweden)

Muhammad Irsyad Alfatih

2017-06-01

In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader. The Leader of an organization is expected to have leadership qualities, which showed his skills in leading organizations. A leader in the library requires synergy between skills in library management and leadership in general in order to create a good working atmosphere and to encourage the library staff in providing the best services to the patron community. Tenteram City Public library since year of 2018 has never experienced a change of its leader. Research using qualitative approach aimed to identify the leadership of Tenteram City public library leader in developing human resources and library services. Data of this study is gathered through observation and interviews. It is found that the head of the library serves as a role model in imbedding working discipline, he never involved the staff in decision making, the fear of making mistake is the working atmosphere created in the library. The Research found that the head of Tenteram City public library adopts autocratic leadership.

LANL Research Library

Science.gov (United States)

Los Alamos National Laboratory The LANL Research Library website has been moved to http ://www.lanl.gov/library/. Please update your bookmarks. If you are not redirected to the new location within 10 http:// | Last Modified: Send email to the Library

The initiatives of a library association for the promotion of grey literature

OpenAIRE

Alberani, V. (ISS); De Castro Pietrangeli, P. (ISS); GreyNet, Grey Literature Network Service

1994-01-01

The main initiatives taken in Italy by the Italian Library Association (AIB) for the development and promotion of grey literature since the recommendations of the seminar of York and following the Italian adhesion to EAGLE (through the Central Library of the Italian National Research Council-CNR) are presented, i.e.: survey the main Italian producers of GL through the application and creation of international and national standards; evaluate the use of grey literature in scientific communicat...

The E-rate Program and Libraries and Library Consortia, 2000-2004: Trends and Issues

Directory of Open Access Journals (Sweden)

Paul T. Jaeger

2005-06-01

Full Text Available The E-rate program has provided tremendous benefits to libraries, allowing many libraries and library systems to acquire technological equipment and services that would otherwise be too expensive, increasing the availability of public Internet access through libraries. This article analyzes the data related to the E-rate program and the discounts that it has provided to libraries and library systems between 2000 and 2004. By examining the E-rate data in a longitudinal manner, this article explores the trends in the application for and the provision of E-rate discounts to libraries and library consortia at national and state levels. The data suggest that, despite a number of controversies over the years, the program has provided a significant level of support for libraries and library consortia.

Applying DEA Technique to Library Evaluation in Academic Research Libraries.

Science.gov (United States)

Shim, Wonsik

2003-01-01

This study applied an analytical technique called Data Envelopment Analysis (DEA) to calculate the relative technical efficiency of 95 academic research libraries, all members of the Association of Research Libraries. DEA, with the proper model of library inputs and outputs, can reveal best practices in the peer groups, as well as the technical…

Female Public Library Patrons Value the Library for Services, Programs, and Technology. A Review of: Fidishun, Dolores. “Women and the Public Library: Using Technology, Using the Library.” Library Trends 56.2 (2007: 328-43.

Directory of Open Access Journals (Sweden)

Virginia Wilson

2009-03-01

Full Text Available Objective – This study attempts to give insight into why and how women use the public library and information technology, and how they learned to use the technology.Design – Qualitative survey.Setting – The research took place at the Chester County Library in Exton, Pennsylvania, USA.Subjects – One hundred and eighty-four female library patrons 18 years and older.Methods – An anonymous qualitative survey was handed out to all patrons at the ChesterCounty Library 18 years of age and older who came into the library on four separate days and times. Times were chosen to obtain a good representation of library patrons, and included daytime, evening, and weekend hours. The survey consisted of questions about library use, information sought, information seeking behaviour, technology used, and how the respondents learned to use the technology. The surveys were collated and spreadsheets were created that reported answers to yes/no and other data questions. Word documents facilitated the listing of more qualitative answers. The data were analyzed using a thematic content analysis to find themes and patterns that emerged to create grounded theory. In thematic content analysis, “the coding scheme is based on categories designed to capture the dominant themes in a text (Franzosi 184. There is no universal coding scheme, and this method requires extensive pre-testing of the scheme (Franzosi 184. Grounded theory “uses a prescribed set of procedures for analyzing data and constructing a theoretical model” from the data (Leedy and Ormrod 154.Main Results – The survey asked questions about library use, reasons for library use, using technology, finding information, and learning to use online resources. A total of 465 surveys were distributed and 329 were returned. From the surveys returned, 184 were from female patrons, 127 from male patrons, and 18 did not report gender. The data for this article are primarily taken from the 184 female