WorldWideScience

Sample records for stages phase-i final

  1. Phase I (or phase II) dose-ranging clinical trials: proposal of a two-stage Bayesian design.

    Science.gov (United States)

    Zohar, Sarah; Chevret, Sylvie

    2003-02-01

    We propose a new design for phase I (or phase II) dose-ranging clinical trials aiming at determining a dose of an experimental treatment to satisfy safety (respectively efficacy) requirements, at treating a sufficiently large number of patients to estimate the toxicity (respectively failure) probability of the dose level with a given reliability, and at stopping the trial early if it is likely that no dose is safe (respectively efficacious). A two-stage design was derived from the Continual Reassessment Method (CRM), with implementation of Bayesian criteria to generate stopping rules. A simulation study was conducted to compare the operating characteristics of the proposed two-stage design to those reached by the traditional CRM. Finally, two applications to real data sets are provided.

  2. U.S. LCI Database Project--Final Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    2003-08-01

    This Phase I final report reviews the process and provides a plan for the execution of subsequent phases of the database project, including recommended data development priorities and a preliminary cost estimate. The ultimate goal of the project is to develop publicly available LCI Data modules for commonly used materials, products, and processes.

  3. Brayton isotope power system, phase I. Final report

    International Nuclear Information System (INIS)

    1978-01-01

    The Phase I program resulted in the development and ground demonstration of a dynamic power conversion system. The two key contractual objectives of 25% conversion efficiency and 1000 h of endurance testing were successfully met. As a result of the Phase I effort, the BIPS is a viable candidate for further development into a flight system capable of sustained operation in space. It represents the only known dynamic space power system to demonstrate the performance and endurance coupled with the simplicity necessary for reliable operation. This final report follows thirty-five monthly reports. For expediency, it makes liberal use of referenced documents which have been submitted to DOE during the course of the program

  4. Phase I Final Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Xijia [National Energy Technology Lab. (NETL), Albany, OR (United States); Fetvedt, Jeremy [National Energy Technology Lab. (NETL), Albany, OR (United States); Dimmig, Walker [National Energy Technology Lab. (NETL), Albany, OR (United States)

    2017-10-15

    This Final Scientific Report addresses the accomplishments achieved during Phase I of DE- FE0023985, Coal Syngas Combustor Development for Supercritical CO2 Power Cycles. The primary objective of the project was to develop a coal syngas-fueled combustor design for use with high-pressure, high-temperature, oxy-fuel, supercritical CO2 power cycles, with particular focus given to the conditions required by the Allam Cycle. The primary goals, from the Statement of Project Objectives, were to develop: (1) a conceptual design of a syngas-fueled combustor-turbine block for a 300MWe high-pressure, oxy-fuel, sCO2 power plant; (2) the preliminary design of a 5MWt test combustor; and (3) the definition of a combustor test program. Accomplishments for each of these goals are discussed in this report.

  5. Microgrid Design, Development and Demonstration - Final Report for Phase I and Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Sumit [GE Global Research Center, Niskayuna, NY (United States); Krok, Michael [GE Global Research Center, Niskayuna, NY (United States)

    2011-02-08

    This document constitutes GE’s final report for the Microgrid Design, Development and Demonstration program for DOE’s Office of Electricity Delivery and Energy Reliability, Award DE-FC02-05CH11349. It contains the final report for Phase I in Appendix I, and the results the work performed in Phase II. The program goal was to develop and demonstrate a Microgrid Energy Management (MEM) framework for a broad set of Microgrid applications that provides unified controls, protection, and energy management. This project contributed to the achievement of the U.S. Department of Energy’s Renewable and Distributed Systems Integration Program goals by developing a fully automated power delivery microgrid network that: - Reduces carbon emissions and emissions of other air pollutants through increased use of optimally dispatched renewable energy, - Increases asset use through integration of distributed systems, - Enhances reliability, security, and resiliency from microgrid applications in critical infrastructure protection, constrained areas of the electric grid, etc. - Improves system efficiency with on-site, distributed generation and improved economic efficiency through demand-side management.

  6. Design of clinical trials Phase I and II with radiopharmaceuticals

    International Nuclear Information System (INIS)

    Giannone, C.A.; Soroa, V.E.

    2015-01-01

    We presented some usual designs for clinical studies in Phase I and Phase II. For Phase I we considered the 3 + 3 Classic design, designs with accelerated titration and those with dose escalation schemes with overdose control (EWOC). For Phase II designs with efficacy outcomes are presented. The design proposed by Fleming is discussed as well as those with inclusion of patients in two stages: Gehan’s design and the Optimal two–stage Simon’s design. We also discussed the design of combined endpoints of efficacy and safety of Bryant and Day with an application example of therapeutically Lu-177. Finally some proposals for phase II trials with control group are considered. (authors) [es

  7. Final waste forms project: Performance criteria for phase I treatability studies

    International Nuclear Information System (INIS)

    Gilliam, T.M.; Hutchins, D.A.; Chodak, P. III

    1994-06-01

    This document defines the product performance criteria to be used in Phase I of the Final Waste Forms Project. In Phase I, treatability studies will be performed to provide open-quotes proof-of-principleclose quotes data to establish the viability of stabilization/solidification (S/S) technologies. This information is required by March 1995. In Phase II, further treatability studies, some at the pilot scale, will be performed to provide sufficient data to allow treatment alternatives identified in Phase I to be more fully developed and evaluated, as well as to reduce performance uncertainties for those methods chosen to treat a specific waste. Three main factors influence the development and selection of an optimum waste form formulation and hence affect selection of performance criteria. These factors are regulatory, process-specific, and site-specific waste form standards or requirements. Clearly, the optimum waste form formulation will require consideration of performance criteria constraints from each of the three categories. Phase I will focus only on the regulatory criteria. These criteria may be considered the minimum criteria for an acceptable waste form. In other words, a S/S technology is considered viable only if it meet applicable regulatory criteria. The criteria to be utilized in the Phase I treatability studies were primarily taken from Environmental Protection Agency regulations addressed in 40 CFR 260 through 265 and 268; and Nuclear Regulatory Commission regulations addressed in 10 CFR 61. Thus the majority of the identified criteria are independent of waste form matrix composition (i.e., applicable to cement, glass, organic binders etc.)

  8. Final waste forms project: Performance criteria for phase I treatability studies

    Energy Technology Data Exchange (ETDEWEB)

    Gilliam, T.M. [Oak Ridge National Lab., TN (United States); Hutchins, D.A. [Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States); Chodak, P. III [Massachusetts Institute of Technology (United States)

    1994-06-01

    This document defines the product performance criteria to be used in Phase I of the Final Waste Forms Project. In Phase I, treatability studies will be performed to provide {open_quotes}proof-of-principle{close_quotes} data to establish the viability of stabilization/solidification (S/S) technologies. This information is required by March 1995. In Phase II, further treatability studies, some at the pilot scale, will be performed to provide sufficient data to allow treatment alternatives identified in Phase I to be more fully developed and evaluated, as well as to reduce performance uncertainties for those methods chosen to treat a specific waste. Three main factors influence the development and selection of an optimum waste form formulation and hence affect selection of performance criteria. These factors are regulatory, process-specific, and site-specific waste form standards or requirements. Clearly, the optimum waste form formulation will require consideration of performance criteria constraints from each of the three categories. Phase I will focus only on the regulatory criteria. These criteria may be considered the minimum criteria for an acceptable waste form. In other words, a S/S technology is considered viable only if it meet applicable regulatory criteria. The criteria to be utilized in the Phase I treatability studies were primarily taken from Environmental Protection Agency regulations addressed in 40 CFR 260 through 265 and 268; and Nuclear Regulatory Commission regulations addressed in 10 CFR 61. Thus the majority of the identified criteria are independent of waste form matrix composition (i.e., applicable to cement, glass, organic binders etc.).

  9. Phase I Cultural Resources Survey and Archeological Inventory of the Segura Staging Area, Iberia Parish, Louisiana

    National Research Council Canada - National Science Library

    2003-01-01

    This document presents the results of a Phase I cultural resources survey and archeological inventory of the Segura Staging Area located on the right descending bank of Bayou Teche at approximate River Mile...

  10. I. Final Report for DOE SBIR Phase I Project DE-SC0013795 Final Report for DOE SBIR Phase I Project DE-SC0013795 Microtron-based Compact, Portable Gamma-Ray Source

    Energy Technology Data Exchange (ETDEWEB)

    Abrams, Robert J. [Muons Inc., Batavia, IL (United States)

    2017-01-09

    versions of microtrons with various energies, sizes and types would be produced and marketed, including a more compact and more portable 6 MeV battery-powered model that more closely meets the requirements in the original FOA topic description. In the course of the Phase I study, we also identified another microtron version, one that was larger (not compact) and more powerful than that of the Phase II prototype, which could serve as an intense source of photo- neutrons, up to 4 x 1012 n/s for use in nuclear medicine, short-lived isotope production, or other applications. In addition, it could produce gamma dose rates up to 130 kR/min-m with a heavy metal bremsstrahlung target. The results and specifications of this were submitted to IPAC16 (Reference [12]) the paper is included in Addendum B. Because this version was beyond the scope of the Phase I project, there is no additional description in the Final Report.

  11. High Performance Nanolauncher, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed Low Cost Nanolauncher (LCN) is an upper stage using a new, inexpensive propulsion system. The Phase I program will combine several technologies with a...

  12. Staging of gastric adenocarcinoma using two-phase spiral CT: correlation with pathologic staging

    International Nuclear Information System (INIS)

    Seo, Tae Seok; Lee, Dong Ho; Ko, Young Tae; Lim, Joo Won

    1998-01-01

    To correlate the preoperative staging of gastric adenocarcinoma using two-phase spiral CT with pathologic staging. One hundred and eighty patients with gastric cancers confirmed during surgery underwent two-phase spiral CT, and were evaluated retrospectively. CT scans were obtained in the prone position after ingestion of water. Scans were performed 35 and 80 seconds after the start of infusion of 120mL of non-ionic contrast material with the speed of 3mL/sec. Five mm collimation, 7mm/sec table feed and 5mm reconstruction interval were used. T-and N-stage were determined using spiral CT images, without knowledge of the pathologic results. Pathologic staging was later compared with CT staging. Pathologic T-stage was T1 in 70 cases(38.9%), T2 in 33(18.3%), T3 in 73(40.6%), and T4 in 4(2.2%). Type-I or IIa elevated lesions accouted for 10 of 70 T1 cases(14.3%) and flat or depressed lesions(type IIb, IIc, or III) for 60(85.7%). Pathologic N-stage was NO in 85 cases(47.2%), N1 in 42(23.3%), N2 in 31(17.2%), and N3 in 22(12,2%). The detection rate of early gastric cancer using two-phase spiral CT was 100.0%(10 of 10 cases) among elevated lesions and 78.3%(47 of 60 cases) among flat or depressed lesions. With regard to T-stage, there was good correlation between CT image and pathology in 86 of 180 cases(47.8%). Overstaging occurred in 23.3%(42 of 180 cases) and understaging in 28.9%(52 of 180 cases). With regard to N-stage, good correlation between CT image and pathology was noted in 94 of 180 cases(52.2%). The rate of understaging(31.7%, 57 of 180 cases) was higher than that of overstaging(16.1%, 29 of 180 cases)(p<0.001). The detection rate of early gastric cancer using two-phase spiral CT was 81.4%, and there was no significant difference in detectability between elevated and depressed lesions. Two-phase spiral CT for determing the T-and N-stage of gastric cancer was not effective;it was accurate in abont 50% of cases understaging tended to occur.=20

  13. Seismic safety margins research program. Phase I final report - Plant/site selection and data collection (Project I)

    International Nuclear Information System (INIS)

    Chuang, T.Y.

    1981-07-01

    Project I of Phase I of the Seismic Safety Margins Research Program (SSMRP) comprised two parts: the selection of a representative nuclear power plant/site for study in Phase I and the collection of data needed by the other SSMRP projects. Unit 1 of the Zion Nuclear Power Plant in Zion, Illinois, was selected for the SSMRP Phase I studies. Unit 1 of the Zion plant has been validated as a good choice for the Phase I study plant. Although no single nuclear power plant can represent all such plants equally well, selection criteria were developed to maximize the generic implications of Phase I of the SSMRP. On the basis of the selection criteria, the Zion plant and its site were found to be reasonably representative of operating and future plants with regard to its nuclear steam supply system; the type of containment structure (prestressed concrete); its electrical capacity (1100 MWe); its location (the Midwest); the peak seismic acceleration used for design (0.17g); and the properties of the underlying soil (the low-strain shear-wave velocity is 1650 ft/s in a 50- to 100-ft-thick layer of soil overlying sedimentary bedrock). (author)

  14. Phase I decontamination of the J.C. Haynes site, Newark, Ohio. Final report

    International Nuclear Information System (INIS)

    Emswiler, T.R.

    1985-11-01

    Phase I consisted of the primary decontamination, packaging, and shipment of all 241 Am-contaminated gloveboxes, vent system, and miscellaneous waste items located in the laboratory restricted area in the J.C. Haynes house. The primary goals of Phase I were to locate and account for a major quantity of 241 Am which was unaccounted for and to remove all radioactive materials and contamination posing an imminent hazard to public health and safety. All Phase I operations were conducted under a Quality Assurance (QA) Program Plan and QA procedures written specifically for this program. In addition, certain generic Battelle QA procedures were used for routine tasks. All operations were conducted under strict health physics supervision and procedures. Cognizant ORAU and US Nuclear Regulatory Commission (NRC) personnel were on site during the entire Phase I operation and provided support and approval in the daily operations. All staff members had participated in previous decontamination and decommissioning programs involving transuranic waste and completed Phase I in a well controlled, timely, and safe manner

  15. Bevalac injector final stage RF amplifier upgrades

    International Nuclear Information System (INIS)

    Howard, D.; Calvert, J.; Dwinell, R.; Lax, J.; Lindner, A.; Richter, R.; Ridgeway, W.

    1991-01-01

    With the assistance of the DOE In-house Energy Management Program, the Bevalac injector final stage RF amplifier systems have been successfully upgraded to reduce energy consumption and operating costs. This recently completed project removed the energy-inefficient plate voltage modulator circuits that were used in conjunction with the final stage RF amplifiers. Construction, design, and operating parameters are described in detail

  16. SP-100 coated-particle fuel development. Phase I. Final report

    International Nuclear Information System (INIS)

    1983-03-01

    This document is the final report of Phase I of the SP-100 Coated-Particle Fuel Development Program conducted by GA Technologies Inc. for the US Department of Energy under contract DE-AT03-82SF11690. The general objective of the study conducted between September and December 1982 was to evaluate coated-particle type fuel as an alternate or backup fuel to the UO 2 tile-and-fin arrangement currently incorporated into the reference design of the SP-100 reactor core. This report presents and discusses the following topics in the order listed: the need for an alternative fuel for the SP-100 nuclear reactor; an abbreviated description of the reference and coated-particle fuel module concepts; the bases and results of the study and analysis leading to the preliminary design of a coated particle suitable for the SP-100 space power reactor; incorporation of the fuel particles into compacts and heat-pipe-cooled modules; initial efforts and plans to fabricate coated-particle fuel and fuel compacts; the design and performance of the proposed alternative core relative that of the reference fuel; and a summary of critical issues and conclusions consistent with the level of effort and duration of the study

  17. 129I Interlaboratory comparison: phase I and phase II

    International Nuclear Information System (INIS)

    Caffee, M. W.; Roberts, M. L.

    1999-01-01

    An interlaboratory comparison exercise for 129 I was organized and conducted. Nine laboratories participated in the exercise to either a full or limited extent. In Phase I of the comparison, 11 samples were measured. The suite of samples contained both synthetic ''standard type'' materials (i.e., AgI) and environmental materials. The isotopic 129 I/ 127 I ratios of the samples varied from 10 -8 to 10 -14 . In this phase, each laboratory was responsible for its own chemical preparation of the samples. In Phase I, the 129 I AMS measurements for prepared AgI were in good agreement. However, large discrepancies were seen in 129 I AMS measurements of environmental samples. Because of the large discrepancies seen in the Phase I 129 I intercomparison, a subsequent study was conducted. In Phase II of the 129 I intercomparison, three separate laboratories prepared AgI from two environmental samples (IAEA 375 soil and maples leaves). Each laboratory used its own chemical preparation method with each of the methods being distinctly different. The resulting six samples (two sets of three) were then re-distributed to the participating 129 I AMS facilities and 129 I/ 127 I ratios measured. Results and discussion of both the Phase I and Phase II interlaboratory comparison are presented

  18. Computational Particle Dynamic Simulations on Multicore Processors (CPDMu) Final Report Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Schmalz, Mark S

    2011-07-24

    Statement of Problem - Department of Energy has many legacy codes for simulation of computational particle dynamics and computational fluid dynamics applications that are designed to run on sequential processors and are not easily parallelized. Emerging high-performance computing architectures employ massively parallel multicore architectures (e.g., graphics processing units) to increase throughput. Parallelization of legacy simulation codes is a high priority, to achieve compatibility, efficiency, accuracy, and extensibility. General Statement of Solution - A legacy simulation application designed for implementation on mainly-sequential processors has been represented as a graph G. Mathematical transformations, applied to G, produce a graph representation {und G} for a high-performance architecture. Key computational and data movement kernels of the application were analyzed/optimized for parallel execution using the mapping G {yields} {und G}, which can be performed semi-automatically. This approach is widely applicable to many types of high-performance computing systems, such as graphics processing units or clusters comprised of nodes that contain one or more such units. Phase I Accomplishments - Phase I research decomposed/profiled computational particle dynamics simulation code for rocket fuel combustion into low and high computational cost regions (respectively, mainly sequential and mainly parallel kernels), with analysis of space and time complexity. Using the research team's expertise in algorithm-to-architecture mappings, the high-cost kernels were transformed, parallelized, and implemented on Nvidia Fermi GPUs. Measured speedups (GPU with respect to single-core CPU) were approximately 20-32X for realistic model parameters, without final optimization. Error analysis showed no loss of computational accuracy. Commercial Applications and Other Benefits - The proposed research will constitute a breakthrough in solution of problems related to efficient

  19. Phase-I monitoring of standard deviations in multistage linear profiles

    Science.gov (United States)

    Kalaei, Mahdiyeh; Soleimani, Paria; Niaki, Seyed Taghi Akhavan; Atashgar, Karim

    2018-03-01

    In most modern manufacturing systems, products are often the output of some multistage processes. In these processes, the stages are dependent on each other, where the output quality of each stage depends also on the output quality of the previous stages. This property is called the cascade property. Although there are many studies in multistage process monitoring, there are fewer works on profile monitoring in multistage processes, especially on the variability monitoring of a multistage profile in Phase-I for which no research is found in the literature. In this paper, a new methodology is proposed to monitor the standard deviation involved in a simple linear profile designed in Phase I to monitor multistage processes with the cascade property. To this aim, an autoregressive correlation model between the stages is considered first. Then, the effect of the cascade property on the performances of three types of T 2 control charts in Phase I with shifts in standard deviation is investigated. As we show that this effect is significant, a U statistic is next used to remove the cascade effect, based on which the investigated control charts are modified. Simulation studies reveal good performances of the modified control charts.

  20. Loading the Saturn I S-IV Stage into Pregnant Guppy

    Science.gov (United States)

    1965-01-01

    The photograph shows the loading operation of the Saturn I S-IV stage (second stage) into the Pregnant Guppy at the Redstone Airfield, Huntsville, Alabama. The Pregnant Guppy was a Boeing B-377 Stratocruiser modified to transport various stages of Saturn launch vehicles. The modification project called for lengthening the fuselage to accommodate the S-IV stage. After the flight test of that modification, phase two called for the enlargement of the plane's cabin section to approximately double its normal volume. The fuselage separated just aft of the wing's trailing edge to load and unload the S-IV and other cargoes.

  1. Multiple-stage pure phase encoding with biometric information

    Science.gov (United States)

    Chen, Wen

    2018-01-01

    In recent years, many optical systems have been developed for securing information, and optical encryption/encoding has attracted more and more attention due to the marked advantages, such as parallel processing and multiple-dimensional characteristics. In this paper, an optical security method is presented based on pure phase encoding with biometric information. Biometric information (such as fingerprint) is employed as security keys rather than plaintext used in conventional optical security systems, and multiple-stage phase-encoding-based optical systems are designed for generating several phase-only masks with biometric information. Subsequently, the extracted phase-only masks are further used in an optical setup for encoding an input image (i.e., plaintext). Numerical simulations are conducted to illustrate the validity, and the results demonstrate that high flexibility and high security can be achieved.

  2. HEAL G-C ICES, Phase II: detailed feasibility analysis and preliminary design. Final report, Stage 1

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    In this preliminary report for Phase II of Health Education Authority of Louisiana's (HEAL) ICES program, specific elements of the basic intitutional issues were readdressed, as requested by the U.S. Department of Energy. The draft environmental assessment was reassessed and updated. Thermal energy demand profiles for the major community sectors, i.e., the five institutions comprising the HEAL Complex, were refined on a month-by-month basis and resulted in establishing ICES plant systems design capacities of 121,500 pounds per hour demand and 418,175,000 pounds per year for steam; 10,000 tons demand and 38,885,000 ton-hours per year for cooling. From these values the concept of the plant was developed. The Phase I capital cost estimate was updated. Total capital cost is now indicated as $29,960,500. The Phase I operating cost estimate was updated, with that figure now $8,468,479. The Phase I financial analysis was updated, producing an estimated annual revenue level of $9,907,062.

  3. Document status for 1 and 2 Kozloduy NPP decommissioning activities -Phase 'Final Shutdown'

    International Nuclear Information System (INIS)

    Vangev, A.; Boyadjiev, Z.

    1997-01-01

    Decommissioning process (D and D) is the final phase of each nuclear reactor life cycle. The first nuclear reactor generation has reached his expiration life date. Decommissioning working documentation had not been taken into account at the project and construction stage. The decommissioning activities, planning and legislation has to develop along their operation. Most of developed nuclear energetic countries have gathered good experience and have create their own decommissioning strategy. This report represents in brief an overview of different country's approaches and the Kozloduy NPP decommissioning activity intention in near future and reviews the D and D working document status for 1 and 2 Kozloduy NPP Units decommissioning. Kozloduy NPP D and D task to the moment is to plan the first stage of the decommissioning process - 'The Final Shutdown' and to prepare the working documents for the phase execution. The Final Shutdown of Kozloduy NPP - 1 is the termination of operation of the Units 1 and 2 and the electricity production cessation after their useful life exhaust. In accordance with the legal legislation in Bulgaria only the normal planned termination of operation on units 1 and 2 should be prescribed. The project results concern the initial condition of the equipment and systems, their preparation and sequence for defueling, decontamination and dismantling. A plan for activities' organization for D and D and Complex Characterization of the Site under consideration will contain the following documents: 1. Time-schedule for the sequence of activities during the stages of the Final Shutdown and Safe Enclosure preparation. Technical project for organization of work related to Final Shutdown; 2. Complex Characterization Programme for a condition investigation of the Units 1 and 2 equipment and systems. 3. Technical project for design modifications and dismantling of equipment and systems which violate the radiation and nuclear safety during the Final Shutdown

  4. A phase I/II study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced T-stage nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Johnson, Faye M.; Garden, Adam S.; Palmer, J. Lynn; Shin, Dong M.; Morrison, William; Papadimitrakopoulou, Vassiliki; Khuri, Fadlo; Clayman, Gary; Goepfert, Helmuth; Ang, K. Kian; Hong, Waun K.; Glisson, Bonnie S.

    2005-01-01

    Purpose: Local recurrence is the most common site of failure for locally advanced nasopharyngeal carcinoma (NPC) treated with neoadjuvant cisplatin/5-fluorouracil (PF) and definitive radiation at our center. Based on this, we studied the addition of chemotherapy during the boost phase of radiation after neoadjuvant PF for advanced T-stage (T3-T4) NPC. This strategy was based on theoretical radiosensitization with chemotherapy during accelerated repopulation of the tumor with relatively radioresistant clonogens. Methods and Materials: Three cycles of neoadjuvant PF was followed by conventionally fractionated radiation with additional PF during the boost portion of the radiation course. An initial Phase I study was done to establish the maximum tolerated dose of concurrent PF. Results: Forty-four patients were enrolled. Six patients in Phase I defined the MTD for concurrent PF as: cisplatin 10 mg/m 2 /day and PF 320 mg/m 2 /day, on Days 1-5 during Weeks 6 and 7 of radiation therapy based on dose-limiting toxicities of mucositis, neutropenia, and thrombocytopenia. Forty-one patients were treated with concurrent therapy per protocol: complete, partial, and minor responses were seen in 23, 16, and 2 patients, respectively. Progression-free and overall survival rates at 5 years were 55% (95% CI, 41-75%) and 66% (95% CI, 52-85%), respectively. Seven of 11 tumor-related deaths were due to local recurrence. Nine of 10 patients with local recurrence had T4-stage disease at presentation. Local control of T4 disease was achieved in 74% of patients overall, and in 25% (1/4) with World Health Organization (WHO) type 1, 76% (16/21) with WHO type 2, and 90% (9/10) with WHO type 3 histology. Common toxicities included mucositis, dermatitis, fatigue, vomiting, and weight loss. Conclusions: This regimen was feasible and associated with promising overall survival. Local recurrence remains the major reason for treatment failure in advanced T-stage NPC, especially WHO types 1 and 2

  5. 77 FR 23741 - DEEPWATER HORIZON Oil Spill; Final Phase I Early Restoration Plan and Environmental Assessment

    Science.gov (United States)

    2012-04-20

    ... (Phase I ERP/EA) describing the first eight restoration projects selected by the Trustees to commence the... notice is to inform the public of the availability of the Phase I ERP/EA. ADDRESSES: Obtaining Documents: You may download the Phase I ERP/EA and the Framework Agreement at http://www.gulfspillrestoration...

  6. The European Dioxin Emission Inventory. Stage II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Quass, U.; Fermann, M.; Broeker, G.

    2001-07-01

    For Stage II of the European Dioxin Project the following objectives were set: - Amendment of existing emission data collected for most relevant emission sources in order to reduce uncertainties of emission estimates. Collecting first emission data from countries not yet performing dioxin emission measurement programs. Extending the inventory of dioxin emissions to ambient air produced in Stage I by a complementary study on emissions to land and water. Extending the regional scope of data collection to countries in Central Europe. The report of Stage II of the European Dioxin Project is presented in 3 Volumes. Volume 1 contains an overview on the background and approach of different activities carried out and on the results obtained. These results are put into a broader view regarding the dioxin reduction measures in Europe leading to conclusions and recommendation for future work. Volume 2 of the report contains a detailed presentation of the sub-projects carried out. The chapters of Volume 2 are structured in a similar manner and start with a short summary in order to allow for a fast cross-reading. In the case of the desk-top studies an overview of the main results or statements is given. Regarding emission measurements details on the experimental set-up and the facilities being investigated are presented. Volume 3 contains a re-evaluation of the dioxin emission inventory presented for the most relevant sources types in the Stage I report. New data gathered from the projects of Stage II as well as from independent activities in the European countries are considered for a revision of the 1995 emission estimates. Additionally, based on current trends and activities the PCDD/F emissions for the years 2000 and 2005 are estimated. Finally, an attempt is made to evaluate the PCDD/F emission reduction rates which might be possible to achieve by the year 2005 compared to 1985. (orig.)

  7. New sensor for measurement of low air flow velocity. Phase I final report

    International Nuclear Information System (INIS)

    Hashemian, H.M.; Hashemian, M.; Riggsbee, E.T.

    1995-08-01

    The project described here is the Phase I feasibility study of a two-phase program to integrate existing technologies to provide a system for determining air flow velocity and direction in radiation work areas. Basically, a low air flow sensor referred to as a thermocouple flow sensor has been developed. The sensor uses a thermocouple as its sensing element. The response time of the thermocouple is measured using an existing in-situ method called the Loop Current Step Response (LCSR) test. The response time results are then converted to a flow signal using a response time-versus-flow correlation. The Phase I effort has shown that a strong correlation exists between the response time of small diameter thermocouples and the ambient flow rate. As such, it has been demonstrated that thermocouple flow sensors can be used successfully to measure low air flow rates that can not be measured with conventional flow sensors. While the thermocouple flow sensor developed in this project was very successful in determining air flow velocity, determining air flow direction was beyond the scope of the Phase I project. Nevertheless, work was performed during Phase I to determine how the new flow sensor can be used to determine the direction, as well as the velocity, of ambient air movements. Basically, it is necessary to use either multiple flow sensors or move a single sensor in the monitoring area and make flow measurements at various locations sweeping the area from top to bottom and from left to right. The results can then be used with empirical or physical models, or in terms of directional vectors to estimate air flow patterns. The measurements can be made continuously or periodically to update the flow patterns as they change when people and objects are moved in the monitoring area. The potential for using multiple thermocouple flow sensors for determining air flow patterns will be examined in Phase II

  8. Free-Piston Stirling Power Conversion Unit for Fission Power System, Phase II Final Report

    Science.gov (United States)

    Wood, J. Gary; Stanley, John

    2016-01-01

    In Phase II, the manufacture and testing of two 6-kW(sub e)Stirling engines was completed. The engines were delivered in an opposed 12-kW(sub e) arrangement with a common expansion space heater head. As described in the Phase I report, the engines were designed to be sealed both hermetically and with a bolted O-ring seal. The completed Phase II convertor is in the bolted configuration to allow future disassembly. By the end of Phase II, the convertor had passed all of the final testing requirements in preparation for delivery to the NASA Glenn Research Center. The electronic controller also was fabricated and tested during Phase II. The controller sets both piston amplitudes and maintains the phasing between them. It also sets the operating frequency of the machine. Details of the controller are described in the Phase I final report. Fabrication of the direct-current to direct-current (DC-DC) output stage, which would have stepped down the main controller output voltage from 700 to 120 V(sub DC), was omitted from this phase of the project for budgetary reasons. However, the main controller was successfully built, tested with the engines, and delivered. We experienced very few development issues with this high-power controller. The project extended significantly longer than originally planned because of yearly funding delays. The team also experienced several hardware difficulties along the development path. Most of these were related to the different thermal expansions of adjacent parts constructed of different materials. This issue was made worse by the large size of the machine. Thermal expansion problems also caused difficulties in the brazing of the opposed stainless steel sodium-potassium (NaK) heater head. Despite repeated attempts Sunpower was not able to successfully braze the opposed head under this project. Near the end of the project, Glenn fabricated an opposed Inconel NaK head, which was installed prior to delivery for testing at Glenn. Engine

  9. Collaborative development of the EPICS Qt framework Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Mayssat, Robert E. [Lyncean Technologies, Inc., Palo Alto, CA (United States)

    2015-01-15

    At Lyncean, a private company spun-off from technology developed at the SLAC National Lab, we have been using EPICS for over a decade. EPICS is ubiquitous on our flagship product – the Compact Light Source. EPICS is not only used to control our laser and accelerator systems, but also to control our x-ray beamlines. The goal of this SBIR is for Lyncean Technologies to spearhead a worldwide collaborative effort for the development of control system tools for EPICS using the Qt framework, a C++-based coding environment that could serve as a competitive alternative to the Java-based Control System Studio (CSS). This grant's Phase I, not unlike a feasibility study, is designed for planning and scoping the preparatory work needed for Phase II or other funding opportunities. The three main objectives of this Phase I are (1) to become better acquainted with the existing EPICS Qt software and Qt framework in order to evaluate the best options for ongoing development, (2) to demonstrate that our engineers can lead the EPICS community and jump-start the Qt collaboration, and (3) to identify a scope for our future work with solicited feedback from the EPICS community. This Phase I report includes key technical findings. It clarifies the differences between the two apparently-competing EPICS Qt implementations, caQtDM and the QE Framework; it explains how to create python-bindings, and compares Qt graphical libraries. But this report is also a personal story that narrates the birth of a collaboration. Starting a collaboration is not the work of a single individual, but the work of many. Therefore this report is also an attempt to publicly give credit to many who supported the effort. The main take-away from this grant is the successful birth of an EPICS Qt collaboration, seeded with existing software from the PSI and the Australian Synchrotron. But a lot more needs to be done for the collaboration founders' vision to be realized, and for the collaboration to reach

  10. Three-phase bone scintigraphy: its contribution to diagnosing and staging avascular necrosis of the carpal lunate

    International Nuclear Information System (INIS)

    Kamburov, D.; Klisarova, A.

    1998-01-01

    Thirty-two patients with avascular necrosis of os lunatum (Kienbock's disease) were examined in three groups according to stage of the disease as follows: first - I stage of disease (10 cases); second - II stage (13) and third - III and IV stages (9). All patients underwent three-phase bone scintigraphy after i v injecting of 20 mCi 99m Tc-MDP. Blood pool index and skeletal index were duly calculated (normal value 1.15). Three-phase bone scintigraphy was within normal limits at 3 patients from the first group. Decreased values of perfusion and bone metabolism were obtained at 2 and 3 patients from the second and third group, respectively. Decreased perfusion and increased bone metabolism (skeletal index < 1.20) were found at 4 patients (group one), 6 (group two) and 3 (group three). Increased blood flow and enhanced uptake of tracer in the late phase were observed at one patient (group one), at 4 group two) and at 6 (group three). False negative results were documented in three cases (group one), and false positive - at one patient each from group two and three. The results show a high sensitivity (91%) of the method in Kienbock's disease and proves that three-phase bone scintigraphy may be used for staging avascular necrosis of the lunate bone. (author)

  11. Hazardous waste management programs; Florida: authorization for interim authorization phase I--Environmental Protection Agency. Notice of final determination.

    Science.gov (United States)

    1982-05-07

    The State of Florida has applied for interim Authorization Phase I. EPA has reviewed Florida's application for Phase I and has determined that Florida's hazardous waste program is substantially equivalent to the Federal program covered by Phase I. The State of Florida is, hereby, granted Interim Authorization for Phase I to operate the State 's hazardous waste program, in lieu of the Federal program.

  12. Final Work Plan: Phase I Investigation at Bladen, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division. Applied Geosciences and Environmental Management Section; Yan, Eugene [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division

    2014-07-01

    The village of Bladen is a town of population approximately 237 in the northwest part of Webster County, Nebraska, 30 mi southwest of Hastings and 140 mi southwest of Lincoln, Nebraska. In 2000, the fumigant-related compound carbon tetrachloride was detected in public water supply well PWS 68-1, at a trace level. Low-level contamination, below the maximum contamination level (MCL) of 5.0 μg/L, has been detected intermittently in well PWS 68-1 since 2000, including in the last sample taken in July 2013. In 2006, the village installed a new well, PWS 2006-1, that remains free of contamination. Because the carbon tetrachloride found in well PWS 68-1 might be linked to historical use of fumigants containing carbon tetrachloride at grain storage facilities, including its former facility in Bladen, the CCC/USDA is proposing an investigation to (1) delineate the source and extent of the carbon tetrachloride contamination potentially associated with its former facility, (2) characterize pathways and controlling factors for contaminant migration in the subsurface, and (3) establish a basis for estimating potential health and environmental risks. The work will be performed in accordance with the Intergovernmental Agreement established between the NDEQ and the Farm Service Agency of the USDA. The site investigation at Bladen will be implemented in phases, so that data collected and interpretations developed during each phase can be evaluated to determine if a subsequent phase of investigation is warranted and, if warranted, to provide effective guidance for the subsequent investigation activities. This Work Plan identifies the specific technical objectives and defines the scope of work proposed for the Phase I investigation by compiling and evaluating historical data. The proposed investigation activities will be performed on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research

  13. California Food Processing Industry Wastewater Demonstration Project: Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Glen; Atkinson, Barbara; Rhyne, Ivin

    2009-09-09

    Wastewater treatment is an energy-intensive process and electricity demand is especially high during the utilities summer peak electricity demand periods. This makes wastewater treatment facilities prime candidates for demand response programs. However, wastewater treatment is often peripheral to food processing operations and its demand response opportunities have often been overlooked. Phase I of this wastewater demonstration project monitored wastewater energy and environmental data at Bell-Carter Foods, Inc., California's largest olive processing plant. For this monitoring activity the project team used Green Energy Management System (GEMS) automated enterprise energy management (EEM) technologies. This report presents results from data collected by GEMS from September 15, 2008 through November 30, 2008, during the olive harvest season. This project established and tested a methodology for (1) gathering baseline energy and environmental data at an industrial food-processing plant and (2) using the data to analyze energy efficiency, demand response, daily peak load management, and environmental management opportunities at the plant. The Phase I goals were to demonstrate the measurement and interrelationship of electricity demand, electricity usage, and water quality metrics and to estimate the associated CO{sub 2} emissions.

  14. Phase I of the Near-Term Hybrid Passenger-Vehicle Development Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-10-01

    Under contract to the Jet Propulsion Laboratory of the California Institute of Technology, Minicars conducted Phase I of the Near-Term Hybrid Passenger Vehicle (NTHV) Development Program. This program led to the preliminary design of a hybrid (electric and internal combustion engine powered) vehicle and fulfilled the objectives set by JPL. JPL requested that the report address certain specific topics. A brief summary of all Phase I activities is given initially; the hybrid vehicle preliminary design is described in Sections 4, 5, and 6. Table 2 of the Summary lists performance projections for the overall vehicle and some of its subsystems. Section 4.5 gives references to the more-detailed design information found in the Preliminary Design Data Package (Appendix C). Alternative hybrid-vehicle design options are discussed in Sections 3 through 6. A listing of the tradeoff study alternatives is included in Section 3. Computer simulations are discussed in Section 9. Section 8 describes the supporting economic analyses. Reliability and safety considerations are discussed specifically in Section 7 and are mentioned in Sections 4, 5, and 6. Section 10 lists conclusions and recommendations arrived at during the performance of Phase I. A complete bibliography follows the list of references.

  15. Relation between initial and minimum final white dwarf mass for Population I stars

    Energy Technology Data Exchange (ETDEWEB)

    Mazzitelli, I.; Dantona, F.

    1986-12-01

    The evolutionary paths for Population I stars having initial masses 1, 2.5, 3, 4, and 5 solar masses were computed from the homogeneous main sequence to the onset of the first major thermal pulse to evaluate the minimum mass and the chemical stratification of the remnant white dwarf (WD) associated with each parent mass. The helium flash phase was followed in detail for a 2.5 solar masses star, whereas for the 1 solar mass star the flash was bypassed, and the models at the beginning of the steady central helium burning phase were obtained by means of a scaling procedure upon the properly computed total and core masses. The results show that for a parent ranging between 1-3 solar masses the core mass at the first thermal pulse ranges only from 0.64-0.69 solar mass. If some very fast mass-loss mechanism is triggered in connection with the early stages of the thermal pulse phase, as suggested by the observed deficiency of asymptotic giant branch stars, the relation between final and initial mass is almost flat at least up to an initial mass of 3 solar masses, and the mass spectrum of the WDs is narrow and heavily peaked around 0.65 solar mass. 53 references.

  16. Relation between initial and minimum final white dwarf mass for Population I stars

    International Nuclear Information System (INIS)

    Mazzitelli, I.; Dantona, F.; CNR, Istituto di Astrofisica Spaziale, Frascati; Roma, Osservatorio Astronomico, Rome, Italy)

    1986-01-01

    The evolutionary paths for Population I stars having initial masses 1, 2.5, 3, 4, and 5 solar masses were computed from the homogeneous main sequence to the onset of the first major thermal pulse to evaluate the minimum mass and the chemical stratification of the remnant white dwarf (WD) associated with each parent mass. The helium flash phase was followed in detail for a 2.5 solar masses star, whereas for the 1 solar mass star the flash was bypassed, and the models at the beginning of the steady central helium burning phase were obtained by means of a scaling procedure upon the properly computed total and core masses. The results show that for a parent ranging between 1-3 solar masses the core mass at the first thermal pulse ranges only from 0.64-0.69 solar mass. If some very fast mass-loss mechanism is triggered in connection with the early stages of the thermal pulse phase, as suggested by the observed deficiency of asymptotic giant branch stars, the relation between final and initial mass is almost flat at least up to an initial mass of 3 solar masses, and the mass spectrum of the WDs is narrow and heavily peaked around 0.65 solar mass. 53 references

  17. Radial compressor for a two-stage heat pump. Phase 2; Compresseur radial pour pompe a chaleur bi-etagee. Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Schiffmann, J.; Favrat, D. [Federal Institute of Technology (EPFL), Industrial Energy Systems Laboratory (LENI), Lausanne (Switzerland); Molyneaux, A. [Ofttech SA, Lausanne (Switzerland)

    2005-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) reviews the results of the second phase of a project carried out at the Federal Institute of Technology in Lausanne, Switzerland, that involved the development of a two-stage heat pump that could replace conventional sources of domestic heating such as oil or gas-fired boilers. This report deals with the construction of a single-stage system to test the basic functions, aerodynamic bearings, drive and compressor and thus prove the correctness of the concept of the system. The results of the tests made are presented and discussed.

  18. PWR steam generator chemical cleaning, Phase I. Final report

    International Nuclear Information System (INIS)

    Rothstein, S.

    1978-07-01

    United Nuclear Industries (UNI) entered into a subcontract with Consolidated Edison Company of New York (Con Ed) on August 8, 1977, for the purpose of developing methods to chemically clean the secondary side tube to tube support crevices of the steam generators of Indian Point Nos. 1 and 2 PWR plants. This document represents the first reporting on activities performed for Phase I of this effort. Specifically, this report contains the results of a literature search performed by UNI for the purpose of determining state-of-the-art chemical solvents and methods for decontaminating nuclear reactor steam generators. The results of the search sought to accomplish two objectives: (1) identify solvents beyond those proposed at present by UNI and Con Ed for the test program, and (2) confirm the appropriateness of solvents and methods of decontamination currently in use by UNI

  19. Dose escalation methods in phase I cancer clinical trials.

    Science.gov (United States)

    Le Tourneau, Christophe; Lee, J Jack; Siu, Lillian L

    2009-05-20

    Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid exposing too many patients to subtherapeutic doses while preserving safety and maintaining rapid accrual. Here we review dose escalation methods for phase I trials, including the rule-based and model-based dose escalation methods that have been developed to evaluate new anticancer agents. Toxicity has traditionally been the primary endpoint for phase I trials involving cytotoxic agents. However, with the emergence of molecularly targeted anticancer agents, potential alternative endpoints to delineate optimal biological activity, such as plasma drug concentration and target inhibition in tumor or surrogate tissues, have been proposed along with new trial designs. We also describe specific methods for drug combinations as well as methods that use a time-to-event endpoint or both toxicity and efficacy as endpoints. Finally, we present the advantages and drawbacks of the various dose escalation methods and discuss specific applications of the methods in developmental oncotherapeutics.

  20. Transuranic (TRU) Waste Phase I Retrieval Plan

    International Nuclear Information System (INIS)

    MCDONALD, K.M.

    1999-01-01

    From 1970 to 1987, TRU and suspect TRU wastes at Hanford were placed in the SWBG. At the time of placement in the SWBG these wastes were not regulated under existing Resource Conservation and Recovery Act (RCRA) regulations, since they were generated and disposed of prior to the effective date of RCRA at the Hanford Site (1987). From the standpoint of DOE Order 5820.2A', the TRU wastes are considered retrievably stored, and current plans are to retrieve these wastes for shipment to WIPP for disposal. This plan provides a strategy for the Phase I retrieval that meets the intent of TPA milestone M-91 and Project W-113, and incorporates the lessons learned during TRU retrieval campaigns at Hanford, LANL, and SRS. As in the original Project W-I13 plans, the current plan calls for examination of approximately 10,000 suspect-TRU drums located in the 218-W-4C burial ground followed by the retrieval of those drums verified to contain TRU waste. Unlike the older plan, however, this plan proposes an open-air retrieval scenario similar to those used for TRU drum retrieval at LANL and SRS. Phase I retrieval consists of the activities associated with the assessment of approximately 10,000 55-gallon drums of suspect TRU-waste in burial ground 218-W-4C and the retrieval of those drums verified to contain TRU waste. Four of the trenches in 218-W-4C (Trenches 1,4,20, and 29) are prime candidates for Phase I retrieval because they contain large numbers of suspect TRU drums, stacked from 2 to 5 drums high, on an asphalt pad. In fact, three of the trenches (Trenches 1,20, and 29) contain waste that has not been covered with soil, and about 1500 drums can be retrieved without excavation. The other three trenches in 218-W-4C (Trenches 7, 19, and 24) are not candidates for Phase I retrieval because they contain significant numbers of boxes. Drums will be retrieved from the four candidate trenches, checked for structural integrity, overpacked, if necessary, and assayed at the burial

  1. Hypofractionated High-Dose Proton Beam Therapy for Stage I Non-Small-Cell Lung Cancer: Preliminary Results of A Phase I/II Clinical Study

    International Nuclear Information System (INIS)

    Hata, Masaharu; Tokuuye, Koichi; Kagei, Kenji; Sugahara, Shinji; Nakayama, Hidetsugu; Fukumitsu, Nobuyoshi; Hashimoto, Takayuki; Mizumoto, Masashi; Ohara, Kiyoshi; Akine, Yasuyuki

    2007-01-01

    Purpose: To present treatment outcomes of hypofractionated high-dose proton beam therapy for Stage I non-small-cell lung cancer (NSCLC). Methods and Materials: Twenty-one patients with Stage I NSCLC (11 with Stage IA and 10 with Stage IB) underwent hypofractionated high-dose proton beam therapy. At the time of irradiation, patient age ranged from 51 to 85 years (median, 74 years). Nine patients were medically inoperable because of comorbidities, and 12 patients refused surgical resection. Histology was squamous cell carcinoma in 6 patients, adenocarcinoma in 14, and large cell carcinoma in 1. Tumor size ranged from 10 to 42 mm (median, 25 mm) in maximum diameter. Three and 18 patients received proton beam irradiation with total doses of 50 Gy and 60 Gy in 10 fractions, respectively, to primary tumor sites. Results: Of 21 patients, 2 died of cancer and 2 died of pneumonia at a median follow-up period of 25 months. The 2-year overall and cause-specific survival rates were 74% and 86%, respectively. All but one of the irradiated tumors were controlled during the follow-up period. Five patients showed recurrences 6-29 months after treatment, including local progression and new lung lesions outside of the irradiated volume in 1 and 4 patients, respectively. The local progression-free and disease-free rates were 95% and 79% at 2 years, respectively. No therapy-related toxicity of Grade ≥3 was observed. Conclusions: Hypofractionated high-dose proton beam therapy seems feasible and effective for Stage I NSCLC. Proton beams may contribute to enhanced efficacy and lower toxicity in the treatment of patients with Stage I NSCLC

  2. Solar photovoltaic/thermal residential experiment. Phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Darkazalli, G.

    1980-07-01

    Month-by-month energy transfer data between an occupied residence and its energy supply systems are presented. The data were obtained during the first phase of photovoltaic/thermal residential research conducted at the University of Texas at Arlington/Solar Energy Research Facility. This research was part of the US Department of Energy Photovoltaic/Thermal Project managed by the M.I.T. Lincoln Laboratory. Energy transfer data are divided into different categories depending on how the energy is consumed. Energy transfers between some system components are also categorized. These components include a flat-plate thermal collector array, a flat-plate photovoltaic array, a dc-to-ac inverter, thermal storage tanks, and a series heat pump. System operations included directing surplus electrical energy (generated by the photovoltaic array) into the local utility grid. The heat pump used off-peak utility power to chill water during the cooling season.

  3. Demonstration of fuel resistant to pellet-cladding interaction. Phase I. Final report

    International Nuclear Information System (INIS)

    Rosenbaum, H.S.

    1979-03-01

    This program has as its ultimate objective the demonstration of an advanced fuel design that is resistant to the failure mechanism known as fuel pellet-cladding interaction (PCI). Two fuel concepts are being developed for possible demonstration within this program: (a) Cu-barrier fuel, and (b) Zr-liner fuel. These advanced fuels (known collectively as barrier fuels) have special fuel cladding designed to protect the Zircaloy cladding tube from the harmful effects of localized stress, and reactive fission products during reactor service. This is the final report for PHASE 1 of this program. Support tests have shown that the barrier fuel resists PCI far better than does the conventional Zircaloy-clad fuel. Power ramp tests thus far have shown good PCI resistance for Cu-barrier fuel at burnup > 12 MWd/kg-U and for Zr-liner fuel > 16 MWd/kg-U. The program calls for continued testing to still higher burnup levels in PHASE 2

  4. A Novel Inflammation-Based Stage (I Stage in Patients with Resectable Esophageal Squamous Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Peng-Cheng Chen

    2016-01-01

    Full Text Available Background. Inflammation plays a key role in cancer. In the current study, we proposed a novel inflammation-based stage, named I stage, for patients with resectable esophageal squamous cell carcinoma (ESCC. Methods. Three hundred and twenty-three patients with resectable ESCC were enrolled in the current study. The I stage was calculated as follows: patients with high levels of C-reactive protein (CRP (>10 mg/L, neutrophil-to-lymphocyte ratio (NLR (>3.5, and platelet-count-to-lymphocyte ratio (PLR (>150 were defined as I3. Patients with two, one, or no abnormal value were defined as I2, I1, or I0, respectively. The prognostic factors were evaluated by univariate and multivariate analyses. Results. There were 112 patients for I0, 97 patients for I1, 66 patients for I2, and 48 patients for I3, respectively. The 5-year cancer-specific survival (CSS in patients with I0, I1, I2, and I3 was 50.0%, 30.9%, 18.2%, and 8.3%, respectively (I0 versus I1, P=0.002; I1 versus I2, P=0.012; I2 versus I3, P=0.020. Multivariate analyses revealed that I stage was an independent prognostic factor in patients with resectable ESCC (P<0.001. Conclusion. The inflammation-based stage (I stage is a novel and useful predictive factor for CSS in patients with resectable ESCC.

  5. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer : a pooled analysis of two randomised trials

    NARCIS (Netherlands)

    Chang, Joe Y.; Senan, Suresh; Paul, Marinus A.; Mehran, Reza J.; Louie, Alexander V.; Balter, Peter; Groen, Harry; McRae, Stephen E.; Widder, Joachim; Feng, Lei; van den Borne, Ben E. E. M.; Munsell, Mark F.; Hurkmans, Coen; Berry, Donald A.; van Werkhoven, Erik; Kresl, John J.; Dingemans, Anne-Marie; Dawood, Omar; Haasbeek, Cornelis J. A.; Carpenter, Larry S.; De Jaeger, Katrien; Komaki, Ritsuko; Slotman, Ben J.; Smit, Egbert F.; Roth, Jack A.

    Background The standard of care for operable, stage I, non-small-cell lung cancer (NSCLC) is lobectomy with mediastinal lymph node dissection or sampling. Stereotactic ablative radiotherapy (SABR) for inoperable stage I NSCLC has shown promising results, but two independent, randomised, phase 3

  6. Liquid-phase problems in steam turbine LP stages

    International Nuclear Information System (INIS)

    Blanc-Feraud, P.

    1978-01-01

    Wet steam formation owing to incipient condensation in final steam turbine pressure stages results in a loss of efficiency and possible rotor blading erosion. The effects of erosion are now clearly understood and quite easily counteracted, but loss of thermodynamics, mechanical and aerodynamic efficiency is still a problem. Only the final LP stages of conventional power station plant operate with wet steam, whereas nuclear plant turbines use it to produce most of their total output [fr

  7. The Final Stages of Massive Star Evolution and Their Supernovae

    Science.gov (United States)

    Heger, Alexander

    In this chapter I discuss the final stages in the evolution of massive stars - stars that are massive enough to burn nuclear fuel all the way to iron group elements in their core. The core eventually collapses to form a neutron star or a black hole when electron captures and photo-disintegration reduce the pressure support to an extent that it no longer can hold up against gravity. The late burning stages of massive stars are a rich subject by themselves, and in them many of the heavy elements in the universe are first generated. The late evolution of massive stars strongly depends on their mass, and hence can be significantly effected by mass loss due to stellar winds and episodic mass loss events - a critical ingredient that we do not know as well as we would like. If the star loses all the hydrogen envelope, a Type I supernova results, if it does not, a Type II supernova is observed. Whether the star makes neutron star or a black hole, or a neutron star at first and a black hole later, and how fast they spin largely affects the energetics and asymmetry of the observed supernova explosion. Beyond photon-based astronomy, other than the sun, a supernova (SN 1987) has been the only object in the sky we ever observed in neutrinos, and supernovae may also be the first thing we will ever see in gravitational wave detectors like LIGO. I conclude this chapter reviewing the deaths of the most massive stars and of Population III stars.

  8. Taiwan industrial cooperation program technology transfer for low-level radioactive waste final disposal - phase I.

    Energy Technology Data Exchange (ETDEWEB)

    Knowlton, Robert G.; Cochran, John Russell; Arnold, Bill Walter; Jow, Hong-Nian; Mattie, Patrick D.; Schelling, Frank Joseph Jr. (; .)

    2007-01-01

    Sandia National Laboratories and the Institute of Nuclear Energy Research, Taiwan have collaborated in a technology transfer program related to low-level radioactive waste (LLW) disposal in Taiwan. Phase I of this program included regulatory analysis of LLW final disposal, development of LLW disposal performance assessment capabilities, and preliminary performance assessments of two potential disposal sites. Performance objectives were based on regulations in Taiwan and comparisons to those in the United States. Probabilistic performance assessment models were constructed based on limited site data using software including GoldSim, BLT-MS, FEHM, and HELP. These software codes provided the probabilistic framework, container degradation, waste-form leaching, groundwater flow, radionuclide transport, and cover infiltration simulation capabilities in the performance assessment. Preliminary performance assessment analyses were conducted for a near-surface disposal system and a mined cavern disposal system at two representative sites in Taiwan. Results of example calculations indicate peak simulated concentrations to a receptor within a few hundred years of LLW disposal, primarily from highly soluble, non-sorbing radionuclides.

  9. Transuranic (TRU) Waste Phase I Retrieval Plan

    International Nuclear Information System (INIS)

    MCDONALD, K.M.

    2000-01-01

    From 1970 to 1987, TRU and suspect TRU wastes at Hanford were placed in the SWBG. At the time of placement in the SWBG these wastes were not regulated under existing Resource Conservation and Recovery Act (RCRA) regulations, since they were generated and disposed of prior to the effective date of RCRA at the Hanford Site (1987). From the standpoint of DOE Order 5820.2A1, the TRU wastes are considered retrievably stored, and current plans are to retrieve these wastes for shipment to WIPP for disposal. This plan provides a strategy for the Phase I retrieval that meets the intent of TPA milestone M-91 and Project W-113, and incorporates the lessons learned during TRU retrieval campaigns at Hanford, LANL, and SRS. As in the original Project W-113 plans, the current plan calls for examination of approximately 10,000 suspect-TRU drums located in the 218-W-4C burial ground followed by the retrieval of those drums verified to contain TRU waste. Unlike the older plan, however, this plan proposes an open-air retrieval scenario similar to those used for TRU drum retrieval at LANL and SRS. Phase I retrieval consists of the activities associated with the assessment of approximately 10,000 55-gallon drums of suspect TRU-waste in burial ground 218-W-4C and the retrieval of those drums verified to contain TRU waste. Four of the trenches in 218-W-4C (Trenches 1, 4, 20, and 29) are prime candidates for Phase I retrieval because they contain large numbers of suspect TRU drums, stacked from 2 to 5 drums high, on an asphalt pad. In fact, three of the trenches (Trenches 1 , 20, and 29) contain waste that has not been covered with soil, and about 1500 drums can be retrieved without excavation. The other three trenches in 218-W-4C (Trenches 7, 19, and 24) are not candidates for Phase I retrieval because they contain significant numbers of boxes. Drums will be retrieved from the four candidate trenches, checked for structural integrity, overpacked, if necessary, and assayed at the burial

  10. HFC-134A and HCFC-22 supermarket refrigeration demonstration and laboratory testing. Phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    Aspen Systems and a team of nineteen agencies and industry participants conducted a series of tests to determine the performance of HFC-134a, HCFC-22, and CFC-502 for supermarket application. This effort constitutes the first phase of a larger project aimed at carrying out both laboratory and demonstration tests of the most viable HFC refrigerants and the refrigerants they replace. The results of the Phase I effort are presented in the present report. The second phase of the project has also been completed. It centered on testing all viable HFC replacement refrigerants for CFC-502. These were HFC-507, HFC-404A, and HFC-407A. The latter results are published in the Phase II report for this project. As part of Phase I, a refrigeration rack utilizing a horizontal open drive screw compressor was constructed in our laboratory. This refrigeration rack is a duplicate of one we have installed in a supermarket in Clifton Park, NY.

  11. ERDA nuclear energy center program. Phase I. Program definition. Final report

    International Nuclear Information System (INIS)

    1977-06-01

    This Phase I report describes the procedures used and the results obtained from a survey of SINB states and major utilities to determine their interest in participating in an ERDA-sponsored study to investigate the technical, economic, and institutional practicality of establishing a potential Nuclear Energy Center at a specific site. The State of South Carolina was the only SINB member to express positive interest in ERDA's Nuclear Energy Center Program, and to offer to submit a proposal through the SINB to select and evaluate a site in South Carolina having the potential for being developed into a Nuclear Energy Center

  12. Grid-connected integrated community energy system. Phase II, Stage 1, final report. Conceptual design, demand and fuel projections and cost analysis

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-08

    The Phase I Report, Grid ICES, presented the broad alternatives and implications for development of an energy system satisfying thermal demand with the co-generation of electric power, all predicated on the use of solid fuels. Participants of the system are the University of Minnesota, operator and primary thermal user, and Northern States Power Company, primary electrical user; with St. Mary's Hospital, Fairview Hospital, and Augsburg College as Add-on Customers for the thermal service (Option I). Included for consideration are the Options of (II) solid waste disposal by the Pyrolysis Method, with heat recovery, and (III) conversion of a portion of the thermal system from steam to hot water distribution to increase co-generation capability and as a demonstration system for future expansion. This report presents the conceptual design of the energy system and each Option, with the economic implications identified so that selection of the final system can be made. Draft outline of the Environmental Assessment for the project is submitted as a separate report.

  13. MHD seed recovery and regeneration, Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    This final report summarizes the work performed by the Space and Technology Division of the TRW Space and Electronics Group for the U.S. Department of Energy, Pittsburgh Energy Technology Center for the Econoseed process. This process involves the economical recovery and regeneration of potassium seed used in the MHD channel. The contract period of performance extended from 1987 through 1994 and was divided into two phases. The Phase II test results are the subject of this Final Report. However, the Phase I test results are presented in summary form in Section 2.3 of this Final Report. The Econoseed process involves the treatment of the potassium sulfate in spent MHD seed with an aqueous calcium formate solution in a continuously stirred reactor system to solubilize, as potassium formate, the potassium content of the seed and to precipitate and recover the sulfate as calcium sulfate. The slurry product from this reaction is centrifuged to separate the calcium sulfate and insoluble seed constituents from the potassium formate solution. The dilute solids-free potassium formate solution is then concentrated in an evaporator. The concentrated potassium formate product is a liquid which can be recycled as a spray into the MHD channel. Calcium formate is the seed regenerant used in the Econoseed process. Since calcium formate is produced in the United States in relatively small quantities, a new route to the continuous production of large quantities of calcium formate needed to support an MHD power industry was investigated. This route involves the reaction of carbon monoxide gas with lime solids in an aqueous medium.

  14. A Dual-Stage Two-Phase Model of Selective Attention

    Science.gov (United States)

    Hubner, Ronald; Steinhauser, Marco; Lehle, Carola

    2010-01-01

    The dual-stage two-phase (DSTP) model is introduced as a formal and general model of selective attention that includes both an early and a late stage of stimulus selection. Whereas at the early stage information is selected by perceptual filters whose selectivity is relatively limited, at the late stage stimuli are selected more efficiently on a…

  15. Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer

    Science.gov (United States)

    2017-11-15

    Stage I Breast Cancer; Stage I Colorectal Cancer AJCC v6 and v7; Stage I Prostate Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage II Colorectal Cancer AJCC v7; Stage II Prostate Cancer; Stage IIA Breast Cancer; Stage IIA Colorectal Cancer AJCC v7; Stage IIA Prostate Cancer; Stage IIB Breast Cancer; Stage IIB Colorectal Cancer AJCC v7; Stage IIB Prostate Cancer; Stage IIC Colorectal Cancer AJCC v7; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7

  16. Simulation Tool for Dielectric Barrier Discharge Plasma Actuators at Atmospheric and Sub-Atmospheric Pressures: SBIR Phase I Final Report

    Science.gov (United States)

    Likhanskii, Alexandre

    2012-01-01

    This report is the final report of a SBIR Phase I project. It is identical to the final report submitted, after some proprietary information of administrative nature has been removed. The development of a numerical simulation tool for dielectric barrier discharge (DBD) plasma actuator is reported. The objectives of the project were to analyze and predict DBD operation at wide range of ambient gas pressures. It overcomes the limitations of traditional DBD codes which are limited to low-speed applications and have weak prediction capabilities. The software tool allows DBD actuator analysis and prediction for subsonic to hypersonic flow regime. The simulation tool is based on the VORPAL code developed by Tech-X Corporation. VORPAL's capability of modeling DBD plasma actuator at low pressures (0.1 to 10 torr) using kinetic plasma modeling approach, and at moderate to atmospheric pressures (1 to 10 atm) using hydrodynamic plasma modeling approach, were demonstrated. In addition, results of experiments with pulsed+bias DBD configuration that were performed for validation purposes are reported.

  17. A Novel Inflammation-Based Stage (I Stage Predicts Overall Survival of Patients with Nasopharyngeal Carcinoma

    Directory of Open Access Journals (Sweden)

    Jian-Pei Li

    2016-11-01

    Full Text Available Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS, modified GPS (mGPS and C-reactive protein/Albumin (CRP/Alb ratio, platelet–lymphocyte ratio (PLR, and neutrophil–lymphocyte ratio (NLR, have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC. In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted. The prognostic factors (GPS, mGPS, CRP/Alb ratios, PLR, and NLR were evaluated using univariate and multivariate analyses. Then, according to the results of the multivariate analyses, we proposed a I stage combination of independent risk factors (CRP/Alb ratio and PLR. The I stage was calculated as follows: patients with high levels of CRP/Alb ratio (>0.03 and PLR (>146.2 were defined as I2; patients with one or no abnormal values were defined as I1 or I0, respectively. The relationships between the I stage and clinicopathological variables and overall survival (OS were evaluated. In addition, the discriminatory ability of the I stage with other inflammation-based prognostic scores was assessed using the AUCs (areas under the curves analyzed by receiver operating characteristics (ROC curves. The p value of <0.05 was considered to be significant. A total of 409 patients with NPC were enrolled in this study. Multivariate analyses revealed that only the CRP/Alb ratio (Hazard ratio (HR = 2.093; 95% Confidence interval (CI: 1.222–3.587; p = 0.007 and PLR (HR: 2.003; 95% CI: 1.177–3.410; p = 0.010 were independent prognostic factors in patients with NPC. The five-year overall survival rates for patients with I0, I1, and I2 were 92.1% ± 2.9%, 83.3% ± 2.6%, and 63.1% ± 4.6%, respectively (p < 0.001. The I stage had a higher area under the curve value (0.670 compared with other systemic inflammation

  18. Model Orlando regionally efficient travel management coordination center (MORE TMCC), phase II : final report.

    Science.gov (United States)

    2012-09-01

    The final report for the Model Orlando Regionally Efficient Travel Management Coordination Center (MORE TMCC) presents the details of : the 2-year process of the partial deployment of the original MORE TMCC design created in Phase I of this project...

  19. Dental Age Estimation (DAE): Data management for tooth development stages including the third molar. Appropriate censoring of Stage H, the final stage of tooth development.

    Science.gov (United States)

    Roberts, Graham J; McDonald, Fraser; Andiappan, Manoharan; Lucas, Victoria S

    2015-11-01

    The final stage of dental development of third molars is usually helpful to indicate whether or not a subject is aged over 18 years. A complexity is that the final stage of development is unlimited in its upper border. Investigators usually select an inappropriate upper age limit or censor point for this tooth development stage. The literature was searched for appropriate data sets for dental age estimation and those that provided the count (n), the mean (x¯), and the standard deviation (sd) for each of the tooth development stages. The Demirjian G and Demirjian H were used for this study. Upper and lower limits of the Stage G and Stage H data were calculated limiting the data to plus or minus three standard deviations from the mean. The upper border of Stage H was limited by appropriate censoring at the maximum value for Stage G. The maximum age at attainment from published data, for Stage H, ranged from 22.60 years to 34.50 years. These data were explored to demonstrate how censoring provides an estimate for the correct maximum age for the final stage of Stage H as 21.64 years for UK Caucasians. This study shows that confining the data array of individual tooth developments stages to ± 3sd provides a reliable and logical way of censoring the data for tooth development stages with a Normal distribution of data. For Stage H this is inappropriate as it is unbounded in its upper limit. The use of a censored data array for Stage H using Percentile values is appropriate. This increases the reliability of using third molar Stage H alone to determine whether or not an individual is over 18 years old. For Stage H, individual ancestral groups should be censored using the same technique. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  20. Results on neutrinoless double beta decay from GERDA phase I

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    After motivating searches of double beta decay and lepton number violation details about the construction, operation and analysis of GERDA will be given. Results of the recently completed phase I of data taking will then be presented and interpreted. Finally an outlook on future plans will be given.

  1. SUPERCRITICAL WATER PARTIAL OXIDATION PHASE I - PILOT-SCALE TESTING / FEASIBILITY STUDIES FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    SPRITZER,M; HONG,G

    2005-01-01

    Under Cooperative Agreement No. DE-FC36-00GO10529 for the Department of Energy, General Atomics (GA) is developing Supercritical Water Partial Oxidation (SWPO) as a means of producing hydrogen from low-grade biomass and other waste feeds. The Phase I Pilot-scale Testing/Feasibility Studies have been successfully completed and the results of that effort are described in this report. The Key potential advantages of the SWPO process is the use of partial oxidation in-situ to rapidly heat the gasification medium, resulting in less char formation and improved hydrogen yield. Another major advantage is that the high-pressure, high-density aqueous environment is ideal for reaching and gasifying organics of all types. The high water content of the medium encourages formation of hydrogen and hydrogen-rich products and is especially compatible with high water content feeds such as biomass materials. The high water content of the medium is also effective for gasification of hydrogen-poor materials such as coal. A versatile pilot plant for exploring gasification in supercritical water has been established at GA's facilities in San Diego. The Phase I testing of the SWPO process with wood and ethanol mixtures demonstrated gasification efficiencies of about 90%, comparable to those found in prior laboratory-scale SCW gasification work carreid out at the University of Hawaii at Manoa (UHM) as well as other biomass gasification experience with conventional gasifiers. As in the prior work at UHM, a significant amount of the hydrogen found in the gas phase products is derived from the water/steam matrix. The studies at UHM utilized an indirectly heated gasifier with an acitvated carbon catalyst. In contrast, the GA studies utilized a directly heated gasifier without catalyst, plus a surrogate waste fuel. Attainment of comparable gasification efficiencies without catalysis is an important advancement for the GA process, and opens the way for efficient hydrogen production from low

  2. COUPLING STATE-OF-THE-SCIENCE SUBSURFACE SIMULATION WITH ADVANCED USER INTERFACE AND PARALLEL VISUALIZATION: SBIR Phase I Final Report

    International Nuclear Information System (INIS)

    Hardeman, B.; Swenson, D.; Finsterle, S.; Zhou, Q.

    2008-01-01

    This is a Phase I report on a project to significantly enhance existing subsurface simulation software using leadership-class computing resources, allowing researchers to solve problems with greater speed and accuracy. Subsurface computer simulation is used for monitoring the behavior of contaminants around nuclear waste disposal and storage areas, groundwater flow, environmental remediation, carbon sequestration, methane hydrate production, and geothermal energy reservoir analysis. The Phase I project was a collaborative effort between Thunderhead Engineering (project lead and developers of a commercial pre- and post-processor for the TOUGH2 simulator) and Lawrence Berkeley National Laboratory (developers of the TOUGH2 simulator for subsurface flow). The Phase I project successfully identified the technical approaches to be implemented in Phase II.

  3. Automatic component calibration and error diagnostics for model-based accelerator control. Phase I final report

    International Nuclear Information System (INIS)

    Carl Stern; Martin Lee

    1999-01-01

    Phase I work studied the feasibility of developing software for automatic component calibration and error correction in beamline optics models. A prototype application was developed that corrects quadrupole field strength errors in beamline models

  4. Automatic component calibration and error diagnostics for model-based accelerator control. Phase I final report

    CERN Document Server

    Carl-Stern

    1999-01-01

    Phase I work studied the feasibility of developing software for automatic component calibration and error correction in beamline optics models. A prototype application was developed that corrects quadrupole field strength errors in beamline models.

  5. Final Phase Flight Performance and Touchdown Time Assessment of TDV in RLV-TD HEX-01 Mission

    Science.gov (United States)

    Yadav, Sandeep; Jayakumar, M.; Nizin, Aziya; Kesavabrahmaji, K.; Shyam Mohan, N.

    2017-12-01

    RLV-TD HEX-01 mission was configured as a precursor flight to actual two stages to orbit vehicle. In this mission RLV-TD was designed as a two stage vehicle for demonstrating the hypersonic flight of a winged body vehicle at Mach No. 5. One of the main objectives of this mission was to generate data for better understanding of new technologies required to design the future vehicle. In this mission, the RLV-TD vehicle was heavily instrumented to get data related to performance of different subsystems. As per the mission design, RLV-TD will land in sea after flight duration of 700 s and travelling a distance of nearly 500 km in Bay of Bengal from the launch site for a nominal trajectory. The visibility studies for telemetry data of vehicle for the nominal and off nominal trajectories were carried out. Based on that, three ground stations were proposed for the telemetry data reception (including one in sea). Even with this scheme it was seen that during the final phase of the flight there will not be any ground station visible to the flight due to low elevation. To have the mission critical data during final phase of the flight, telemetry through INSAT scheme was introduced. During the end of the mission RLV-TD will be landing in the sea on a hypothetical runway. To know the exact time of touchdown for the flight in sea, there was no direct measurement available. Simultaneously there were all chances of losing ground station visibility just before touchdown, making it difficult to assess flight performance during that phase. In this work, telemetry and instrumentation scheme of RLV-TD HEX-01 mission is discussed with an objective to determine the flight performance during the final phase. Further, using various flight sensor data the touchdown time of TDV is assessed for this mission.

  6. Membrane/distillation hybrid process research and development. Final report, phase II

    Energy Technology Data Exchange (ETDEWEB)

    Mazanec, T.J.

    1997-07-01

    This report covers work conducted under the grant awarded to BP by DOE in late 1991 entitled {open_quotes}Membrane/Distillation Hybrid Process Research and Development.{close_quotes} The program was directed towards development and commercialization of the BP process for separation of vapor phase olefins from non-olefins via facilitated transport using an aqueous facilitator. The program has come to a very successful conclusion, with formation of a partnership between BP and Stone and Webster Engineering Corporation (SWEC) to market and commercialize the technology. The focus of this report is the final portion of the program, during which engineering re-design, facilitator optimization, economic analysis, and marketing have been the primary activities. At the end of Phase II BP was looking to partner with an engineering firm to advance the selective olefin recovery (SOR) technology from the lab/demo stage to full commercialization. In August 1995 BP and SWEC reached an agreement to advance the technology by completing additional Phase III work with DOE and beginning marketing activities.

  7. Hydrogeological and hydrogeochemical investigations in boreholes - Final report of the phase I geochemical investigations of the Stripa groundwaters

    International Nuclear Information System (INIS)

    Nordstroem, D.K.; Carlsson, L.; Fontes, J.C.; Frits, P.; Moser, H.; Olsson, T.

    1985-07-01

    The hydrogeochemical investigations of Phase I of the Stripa Project (1980-1984) have been completed, and the results are presented in this final report. All chemical and isotopic data on the groundwaters from the beginning to the Stripa Project to the present (1977-84) are tabulated an used in the final interpretations. The background geology and hydrology is summarized and updated along with new analyses of the Stripa grantie. Water-rock interactions form a basic framework for the changes in major-element chemistry with depth, including carbonate geochemistry, the fluid-inclusion hypothesis, redox processes, and mineral precipitation. The irregular distribution of chloride suggests channelling is occurring and the effect of thermomechanical perturbations on the groundwater chemistry is documented. Stable and radioactive isotpes provide information of the origin and evolution of the groundwater itself and of several elments within the groundwater. Subsurface production of radionuclides is documented in these investigations, and a general picture of uranium transformations during weathering is presented. One of the primary conclusions reached in these studies is that different dissolved constituents will provide different residence times because they have different origins and different evolutionary histories that may or may not be related to the overall evolution of the groundwater itself. (author)

  8. Adjuvant chemotherapy for stage I non-seminomatous testicular ...

    African Journals Online (AJOL)

    Adjuvant chemotherapy for stage I non-seminomatous testicular cancer. R. P. Abratt, A. R. Pontin, R. D. Barnes, B. V. Reddi. Developments in the treatment of stage I ... taxing for patients.·. Analysis of tumour histology in the orchidectomy specimen in patients entered into surveillance studies led to the identification of risk ...

  9. DOE SBIR Phase I Grant No. DE-FG02-00ER83067, ''A Flexible and Economical Automated Nucleophilic [18F]Fluorination synthesis System for PET Radiopharmaceuticals.'' Final Technical Report

    International Nuclear Information System (INIS)

    Padgett, Henry C.

    2001-01-01

    Phase I Final Report. A prototype manual remote synthesis system based on the unit operations approach was designed, constructed, and functionally tested. This general-purpose system was validated by its configuration and initial use for the preparation of the PET radiopharmaceutical [F-18]FLT using [F-18]fluoride ion

  10. SUPERCRITICAL WATER PARTIAL OXIDATION PHASE I - PILOT-SCALE TESTING/FEASIBILTY SUDIES FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    SPRITZER.M; HONG,G

    2005-01-01

    General Atomics (GA) is developing Supercritical Water Partial Oxidation (SWPO) as a means of producing hydrogen from low-grade biomass and other waste feeds. The Phase I Pilot-scale Testing/Feasibility Studies have been successfully completed and the results of that effort are described in this report. The key potential advantage of the SWPO process is the use of partial oxidation in-situ to rapidly heat the gasification medium, resulting in less char formation and improved hydrogen yield. Another major advantage is that the high-pressure, high-density aqueous environment is ideal for reacting and gasifying organics of all types. The high water content of the medium encourages formation of hydrogen and hydrogen-rich products and is especially compatible with high water content feeds such as biomass materials. The high water content of the medium is also effective for gasification of hydrogen-poor materials such as coal. A versatile pilot plant for exploring gasification in supercritical water has been established at GA's facilities in San Diego. The Phase I testing of the SWPO process with wood and ethanol mixtures demonstrated gasification efficiencies of about 90%, comparable to those found in prior laboratory-scale SCW gasification work carried out at the University of Hawaii at Manoa (UHM), as well as other biomass gasification experience with conventional gasifiers. As in the prior work at UHM, a significant amount of the hydrogen found in the gas phase products is derived from the water/steam matrix. The studies at UHM utilized an indirectly heated gasifier with an activated carbon catalyst. In contrast, the GA studies utilized a directly heated gasifier without catalyst, plus a surrogate waste fuel. Attainment of comparable gasification efficiencies without catalysis is an important advancement for the GA process, and opens the way for efficient hydrogen production from low-value, dirty feed materials. The Phase I results indicate that a practical

  11. [The role of Sabin inactivated poliovirus vaccine in the final phase of global polio eradication].

    Science.gov (United States)

    Dong, S Z; Zhu, W B

    2016-12-06

    Global polio eradication has entered its final phase, but still faces enormous challenges. The Polio Eradication and Endgame Strategic Plan (2013-2018) set the target for making the world polio-free by 2018. Meanwhile, the World Heath Organization Global Action Plan (GAP Ⅲ) recommended that polioviruses be stored under strict conditions after eradication of the wild poliovirus. At least one dose of inactivated poliovirus vaccine (IPV) would be required for each newborn baby in the world to ensure successful completion of the final strategy and GAP Ⅲ. The Sabin IPV has a high production safety and low production cost, compared with the wild-virus IPV and, therefore, can play an important role in the final stage of global polio eradication.

  12. Advanced direct liquefaction concepts for PETC generic units. Final report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    The Advanced Concepts for Direct Coal Liquefaction program was initiated by the Department of Energy in 1991 to develop technologies that could significantly reduce the cost of producing liquid fuels by the direct liquefaction of coal. The advanced 2-stage liquefaction technology that was developed at Wilsonville over the past 10 years has contributed significantly toward decreasing the cost of producing liquids from coal to about $33/bbl. It remains, however, the objective of DOE to further reduce this cost to a level more competitive with petroleum based products. This project, among others, was initiated to investigate various alternative approaches to develop technologies that might ultimately lead to a 25 % reduction in cost of product. In this project a number of novel concepts were investigated, either individually or in a coupled configuration that had the potential to contribute toward meeting the DOE goal. The concepts included mature technologies or ones closely related to them, such as coal cleaning by oil agglomeration, fluid coking and distillate hydrotreating and dewaxing. Other approaches that were either embryonic or less developed were chemical pretreatment of coal to remove oxygen, and dispersed catalyst development for application in the 2-stage liquefaction process. This report presents the results of this project. It is arranged in four sections which were prepared by participating organizations responsible for that phase of the project. A summary of the overall project and the principal results are given in this section. First, however, an overview of the process economics and the process concepts that were developed during the course of this program is presented.

  13. Interpreting survival data from clinical trials of surgery versus stereotactic body radiation therapy in operable Stage I non-small cell lung cancer patients.

    Science.gov (United States)

    Samson, Pamela; Keogan, Kathleen; Crabtree, Traves; Colditz, Graham; Broderick, Stephen; Puri, Varun; Meyers, Bryan

    2017-01-01

    To identify the variability of short- and long-term survival outcomes among closed Phase III randomized controlled trials with small sample sizes comparing SBRT (stereotactic body radiation therapy) and surgical resection in operable clinical Stage I non-small cell lung cancer (NSCLC) patients. Clinical Stage I NSCLC patients who underwent surgery at our institution meeting the inclusion/exclusion criteria for STARS (Randomized Study to Compare CyberKnife to Surgical Resection in Stage I Non-small Cell Lung Cancer), ROSEL (Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer), or both were identified. Bootstrapping analysis provided 10,000 iterations to depict 30-day mortality and three-year overall survival (OS) in cohorts of 16 patients (to simulate the STARS surgical arm), 27 patients (to simulate the pooled surgical arms of STARS and ROSEL), and 515 (to simulate the goal accrual for the surgical arm of STARS). From 2000 to 2012, 749/873 (86%) of clinical Stage I NSCLC patients who underwent resection were eligible for STARS only, ROSEL only, or both studies. When patients eligible for STARS only were repeatedly sampled with a cohort size of 16, the 3-year OS rates ranged from 27 to 100%, and 30-day mortality varied from 0 to 25%. When patients eligible for ROSEL or for both STARS and ROSEL underwent bootstrapping with n=27, the 3-year OS ranged from 46 to 100%, while 30-day mortality varied from 0 to 15%. Finally, when patients eligible for STARS were repeatedly sampled in groups of 515, 3-year OS narrowed to 70-85%, with 30-day mortality varying from 0 to 4%. Short- and long-term survival outcomes from trials with small sample sizes are extremely variable and unreliable for extrapolation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Gurney, Kevin R. [Arizona Univ., Mesa, AZ (United States)

    2015-01-12

    This document constitutes the final report under DOE grant DE-FG-08ER64649. The organization of this document is as follows: first, I will review the original scope of the proposed research. Second, I will present the current draft of a paper nearing submission to Nature Climate Change on the initial results of this funded effort. Finally, I will present the last phase of the research under this grant which has supported a Ph.D. student. To that end, I will present the graduate student’s proposed research, a portion of which is completed and reflected in the paper nearing submission. This final work phase will be completed in the next 12 months. This final workphase will likely result in 1-2 additional publications and we consider the results (as exemplified by the current paper) high quality. The continuing results will acknowledge the funding provided by DOE grant DE-FG-08ER64649.

  15. Second stage of Saturn V being assembled with the first stage.

    Science.gov (United States)

    1965-01-01

    The hydrogen-powered second stage is being lowered into place during the final phase of fabrication of the Saturn V moon rocket at North American's Seal Beach, California facility. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

  16. Hodgkin's disease: correlation of clinical characteristics with probabilities for negative lymphangiogram vs. negative laparotomy findings in patients with stage I supradiaphragmatic presentations vs. those in patients with stage II

    International Nuclear Information System (INIS)

    Fuller, Lillian M.; Mirza, Nadeem Q.; Palmer, J. Lynn; Davis, Barry R.; Ha, Chul S.; Rodriguez, M. Alma; Hagemeister, Fredrick B.; Cabanillas, Fernando; McLaughlin, Peter; Butler, James J.; North, Luceil B.; Martin, Richard G.

    1998-01-01

    Purpose: At a time both when late complications and second malignancies have become a growing concern and when staging laparotomy has been largely abandoned and comparative studies for staging Hodgkin's disease by state of the art computed tomography (CT) vs. lymphangiography have revealed minimal differences in results for these procedures, our purpose for undertaking this study was twofold. Our initial reason was to determine and compare probabilities for negative abdominal findings for patients with Stage I presentations with those for patients with Stage II as determined by lymphangiography and subsequently by laparotomy for those patients who had negative lymphangiograms. Our second reason, being an extension of the first, was to create a resource that can be used in conjunction with other information for arriving at appropriate treatment decisions including giving either more or particularly less than standard institutional therapy and especially with respect to the abdomen. Methods and Materials: Data on 714 patients with prelymphangiogram Stage I-II upper torso presentations of Hodgkin's disease were entered prospectively in our database between 1968 and 1987. Twenty-eight with lymphocyte predominant disease, who had both negative lymphangiogram and negative laparotomy findings and 17 with questionable diagnoses of lymphocyte-depleted or unclassified disease were excluded from subsequent analyses of 669 patients with nodular sclerosis (NS) and mixed cellularity (MC) diagnoses. Results: Stage I: in final logistic models, negative lymphangiogram findings were associated strongly with a combination of no constitutional symptoms and nodular sclerosis histology, whereas negative laparotomy findings correlated strongly with a combination of no constitutional symptoms and female sex. Predicted probabilities depended on the ratios of favorable to unfavorable characteristics. Stage II: in final logistic models, negative lymphangiogram findings were associated

  17. Early mortality estimates for different nuclear accidents. Final Phase I report, October 1977-April 1979

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, F.F.

    1979-08-01

    Several studies have previously been made of the number of early deaths which might be expected in a population exposed to a cloud of radionuclides which could result from a nuclear accident. These analyses, however, have been limited to one accident scenario or to exposures involving limited numbers of radionuclides. The purpose of this Phase I study was to examine the existing data on the early health effects of inhaled radioactive materials and determined what, if any, new studies were needed to make reasonable estimates of early mortality after exposure of a population to a cloud of radionuclides of any type. The approach used in the Phase I project was to analyze the data bases available on the health effects of inhaled radioactive materials and document those which were adequate and useful. Using these data, a computer based simulation model was developed depicting exposure to a radioactive aerosol, the dose to an individual exposed to the aerosol and the probability of dying from early effects.

  18. Early mortality estimates for different nuclear accidents. Final Phase I report, October 1977-April 1979

    International Nuclear Information System (INIS)

    Hahn, F.F.

    1979-08-01

    Several studies have previously been made of the number of early deaths which might be expected in a population exposed to a cloud of radionuclides which could result from a nuclear accident. These analyses, however, have been limited to one accident scenario or to exposures involving limited numbers of radionuclides. The purpose of this Phase I study was to examine the existing data on the early health effects of inhaled radioactive materials and determined what, if any, new studies were needed to make reasonable estimates of early mortality after exposure of a population to a cloud of radionuclides of any type. The approach used in the Phase I project was to analyze the data bases available on the health effects of inhaled radioactive materials and document those which were adequate and useful. Using these data, a computer based simulation model was developed depicting exposure to a radioactive aerosol, the dose to an individual exposed to the aerosol and the probability of dying from early effects

  19. 77 FR 33097 - Application To Participate in an Auction for Mobility Fund Phase I Support and Application for...

    Science.gov (United States)

    2012-06-05

    ... America Fund & Intercarrier Compensation Reform Order (Order), FCC 11-161 and a Bureau Order, DA 12-147...-147] Application To Participate in an Auction for Mobility Fund Phase I Support and Application for Mobility Fund Phase I Support AGENCY: Federal Communications Commission. ACTION: Final rule; announcement...

  20. Radiotoxicity of Actinides During Transmutation in Final Stage of Atomic Power

    International Nuclear Information System (INIS)

    Gerasimov, Aleksander S.; Bergelson, Boris R.; Myrtsymova, Lidia A.; Tikhomirov, Georgy V.

    2002-01-01

    Characteristics of a transmutation mode in final stage of atomic power are analyzed. In this stage, transmutation of actinides accumulated in transmutation reactors is performed without feed by actinides from other reactors. The radiotoxicity during first 20 years of transmutation is caused mainly by 244 Cm. During following period of time, 252 Cf is main nuclide. Contribution of 246 Cm and 250 Cf is 5-7 times less than that of 252 Cf. During 50 years of a transmutation, the total radiotoxicity falls by 50 times. Long-lived radiotoxicity decreases slowly. During the period between T=50 years and T=100 years, long-lived radiotoxicity falls by 3.7 times. For each following 50 years after this period, long-lived radiotoxicity falls by 3.2 times. These results corresponding to neutron flux density 10 14 neutr/(cm 2 s) in transmutation reactor demonstrate that the final stage of a transmutation should be performed with use of high flux transmutation facilities which provide shorter time of transmutation. (authors)

  1. Continuous fiber ceramic composite. Phase I final report, April 1992--April 1993

    Energy Technology Data Exchange (ETDEWEB)

    Goettler, R.W.

    1995-04-01

    Babcock and Wilcox assembled a team to develop the Continuous Fiber Ceramic Composite (CFCC) processing technology, identify the industrial applications, generate design and life prediction software, and to begin the necessary steps leading to full commercialization of CFCC components. Following is a summary of Phase I activities on this program. B&W has selected an oxide-oxide composite system for development and optimization in this program. This selection was based on the results of exposure tests in combustion environments typical of the boiler and heat exchanger applications. Aluminum oxide fiber is the selected reinforcement, and both aluminum oxide and zirconium oxide matrices were selected, based on their superior resistance to chemical attack in hostile industrial service.

  2. Stage I carcinoma of the endometrium: Some prognostic factors

    International Nuclear Information System (INIS)

    Perry, H.; Lefkofsky, M.M.; Chang, H.S.; Mantel, J.

    1987-01-01

    A total of 446 patients with FIGO stage I adenocarcinoma of the endometrium were treated from 1953 to 1980. The overall actuarial survival was 80.77% at 5 years and 72.16% at 10 years. The 5- and 10-year actuarial survivals for various stages are as follows: stage IA: 82.33% and 73.12%; stage IB: 79.80% and 71.55% (P = .4045); stage IB, grade I: 87l.34% and 79.29%; grade II, 83.11% and 75.52%; grade III, 53.62% and 48.53% (P = .0000); stage IC: for patients receiving preoperative radiation therapy with residual carcinoma in the operative specimen, 86.26% and 79.76%; for specimens containing residual tumor, 76.41% and 68.31% (P = .0802). Patient selection appeared to influence survival

  3. Adjuvant radiotherapy for stage I endometrial cancer.

    Science.gov (United States)

    Kong, A; Johnson, N; Cornes, P; Simera, I; Collingwood, M; Williams, C; Kitchener, H

    2007-04-18

    The role of adjuvant radiotherapy (both pelvic external beam radiotherapy and vaginal intracavity brachytherapy) in stage I endometrial cancer following total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO) remains unclear. To assess the efficacy of adjuvant radiotherapy following surgery for stage I endometrial cancer. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CancerLit, Physician Data Query (PDQ) of National Cancer Institute. Handsearching was also carried out where appropriate. Randomised controlled trials (RCTs) which compared adjuvant radiotherapy versus no radiotherapy following surgery for patients with stage I endometrial cancer were included. Quality of the studies was assessed and data collected using a predefined data collection form. The primary endpoint was overall survival. Secondary endpoints were locoregional recurrence, distant recurrence and endometrial cancer death. Data on quality of life (QOL) and morbidity were also collected. A meta-analysis on included trials was performed using the Cochrane Collaboration Review Manager Software 4.2. The meta-analysis was performed on four trials (1770 patients). The addition of pelvic external beam radiotherapy to surgery reduced locoregional recurrence, a relative risk (RR) of 0.28 (95% confidence interval (CI) 0.17 to 0.44, p ASTEC; Lukka) are awaited. External beam radiotherapy carries a risk of toxicity and should be avoided in stage 1 endometrial cancer patients with no high risk factors.

  4. Grid-connected integrated community energy system. Phase II, Stage 2, final report. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    The University of Minnesota Grid-ICES was divided into four identifiable programs in order to study the feasibility of each of the parts of the ICES independently. The total program involves cogeneration, fuel conversion, fuel substitution, and energy conservation by system change. This Phase II report substantiates the theory that the Basic Grid ICES is not only energy-effective, but it will become cost effective as unit operating costs adjust to supply and demand in the 1980's. The Basic Program involves the cogeneration of steam and electricity. The University of Minnesota has been following an orderly process of converting its Central Heating Plant from gas-oil to 100% coal since 1973. The first step in the transition is complete. The University is presently 100% on coal, and will begin the second step, the test burning of low Btu Western coal during the spring, summer, and fall, and high Btu Eastern coal during the high thermal winter period. The final step to 100% Western coal is planned to be completed by 1980. In conjunction with the final step a retired Northern States Power generating plant has been purchased and is in the process of being retrofitted for topping the existing plant steam output during the winter months. The Basic Plan of ICES involves the add-on work and expense of installing additional boiler capacity at Southeast Steam and non-condensing electric generating capability. This will permit the simultaneous generation of electricity and heat dependent upon the thermal requirements of the heating and cooling system in University buildings. This volume presents an overview of the Community and the ICES. (MCW)

  5. GTS Duratek, phase I Hanford low-level waste melter tests: Final report

    International Nuclear Information System (INIS)

    Eaton, W.C.

    1995-01-01

    A multiphase program was initiated in 1994 to test commercially available melter technologies for the vitrification of the low-level waste (LLW) stream from defense waste stored in underground tanks at the Hanford Site in southeastern Washington State. Phase 1 of the melter demonstration tests using simulated LLW was completed during fiscal year 1995. This document is the final report on testing performed by GTS Duratek Inc. in Columbia, Maryland. GTS Duratek (one of the seven vendors selected) was chosen to demonstrate Joule heated melter technology under WHC subcontract number MMI-SVV-384215. The report contains description of the tests, observations, test data and some analysis of the data as it pertains to application of this technology for LLW vitrification. The document also contains summaries of the melter offgas reports issued as separate documents for the 100 kg melter (WHC-SD-WM-VI-028) and for the 1000 kg melter (WHC-SD-WM-VI-029)

  6. Ocean thermal energy conversion power system development-I. Preliminary design report. Volume 3. Appendixes D, E, and F. Phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-18

    The conceptual design of a 40 to 50 MW closed cycle ammonia OTEC commercial plant, the preliminary design of a 10 MW OTEC module analogous to the 50 MW module, and the preliminary design of heat exchanger test articles (evaporator and condenser) representative of the 50 MW heat exchangers for testing in OTEC-1 are presented. This volume includes the appendices: D) system equipment (hardware breakdown structure; 10-MW hardware listing; list of support and maintenance equipment, tools and spare parts; sacrificial anodes; M.A.N. brush; and Alclad 3004 data); E) heat exchanger supporting data (analyses/configuration, contract tooling, manufacturing plan, specification, and evaporator ammonia liquid distribution system); and F) rotating machinery (performance characteristics, radial inflow turbine; item descriptions; weight calculation-rotor; producibility analysis; long lead-time items; spares; support equipment; non recurring costs; performance characteristics-axial flow turbine; Worthington pump data; and American M.A.N. Corporation data). Also included is attachment 1 to the phase I final report which presents details of the system modeling; design, materials considerations, and systems analysis of the baseline module; system cost analysis; and supporting data. (WHK)

  7. Depth Profile of Impurity Phase in Wide-Bandgap Cu(In1-x ,Ga x )Se2 Film Fabricated by Three-Stage Process

    Science.gov (United States)

    Wang, Shenghao; Nazuka, Takehiro; Hagiya, Hideki; Takabayashi, Yutaro; Ishizuka, Shogo; Shibata, Hajime; Niki, Shigeru; Islam, Muhammad M.; Akimoto, Katsuhiro; Sakurai, Takeaki

    2018-02-01

    For copper indium gallium selenide [Cu(In1-x ,Ga x )Se2, CIGS]-based solar cells, defect states or impurity phase always form due to both the multinary compositions of CIGS film and the difficulty of controlling the growth process, especially for high Ga concentration. To further improve device performance, it is important to understand such formation of impurity phase or defect states during fabrication. In the work presented herein, the formation mechanism of impurity phase Cu2-δ Se and its depth profile in CIGS film with high Ga content, in particular CuGaSe2 (i.e., CGS), were investigated by applying different growth conditions (i.e., normal three-stage process and two-cycle three-stage process). The results suggest that impurity phase Cu2-δ Se is distributed nonuniformly in the film because of lack of Ga diffusion. The formed Cu2-δ Se can be removed by etching the as-deposited CGS film with bromine-methanol solution, resulting in improved device performance.

  8. The impacts of the final phase of transition to IFRS in Brazil

    Directory of Open Access Journals (Sweden)

    Clênia de Oliveira Pires

    2015-08-01

    Full Text Available Objective – This article aims to measure the impacts of the final phase of mandatory convergence to IFRS on net income, in equity and total assets of Brazilian publics companies. Design/methodology/approach – It is applied to the inverse of Gray (1980’s Conservatism Index – which allows you to compare the results between different accounting systems – to determine the impacts of the transition between the two phases of the convergence process in Brazil, covered by the law 11,638 and their CPCs. It was compared the 2009 financial results disclosed in BR GAAP and IFRS. Findings – The results show that the final stage of mandatory convergence to IFRS led to significant increases in both net income and the shareholders’ equity of the companies analysed: a mean increase of about 21% in earnings and about 11% in equity, as well as generating an increase, though somewhat less significant, about 7%, the total assets. Practical implications – This research helped to improve understanding of the impacts of convergence of Brazilian accounting to the international standard; as well as to assist business managers and users of financial information, especially those from the capital markets, regulators and academia, about the ultimate effects on the results reported in 2011, after the implementation of the final phase of convergence. Originality/value – The fiscal year of 2009 was a special year for understanding the impact of accounting system in the financial results disclosed in Brazil. The Brazilian publics companies reported their results in BR GAAP and IFRS and this research analysed and compare both reports and improve understanding of the impacts of convergence of Brazilian accounting to the international standard.

  9. Therapy for stage I aggressive non-Hodgkin's lymphoma

    NARCIS (Netherlands)

    Kluin-Nelemans, Hanneke

    2002-01-01

    Although radiotherapy was considered sufficient for stage I and limited stage II aggressive non-Hodgkin's lymphoma in the past, new data from randomized studies have shown that intensified chemotherapy or combined modality therapy (multiagent chemotherapy followed by involved field radiotherapy) can

  10. Vapor Compressor Driven Hybrid Two-Phase Loop, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will demonstrate a vapor compressor driven hybrid two-phase loop technology. The hybrid two-phase loop...

  11. ROBUSTIFICATION OF MULTIVARIATE CONTROL CHART √|S| IN CONTROL PHASE I

    Directory of Open Access Journals (Sweden)

    Edwin Dugarte-Peña

    2016-07-01

    Full Text Available This article, chart robustification based on the square root of the sample generalized variance √|S|, is studied to control the variability of a bivariate normal process in stage 1 of Phase I control, built with observations for rational subgroups, and using the robust estimators, MVE, MCD and estimator S. These charts, are being compared with the usual chart, based on unbiased sample estimator, S, of the covariance matrix, ∑_0, in the presence of outliers from perturbation schemes such as, ∑_0 inflation contamination, and contamination affecting only the correlation. We use as performance measure, the mean squared error in estimating ∑_0, and absolute bias in the estimate, used √(|∑_0 | , about the unbiased estimators for each one of the parameters respectively    built with the rational subgroups that remain after the purification process undertaken in Phase 1 and are consider as the data group that represent the stage of the stable variation process.

  12. A Phase 1 Trial of an Immune Checkpoint Inhibitor plus Stereotactic Ablative Radiotherapy in Patients with Inoperable Stage I Non-Small Cell Lung Cancer

    Science.gov (United States)

    2017-10-01

    with Inoperable Stage I Non-Small Cell Lung Cancer PRINCIPAL INVESTIGATOR: Karen Kelly, MD CONTRACTING ORGANIZATION: University of California...Inhibitor plus Stereotactic Ablative Radiotherapy in Patients with Inoperable Stage I Non-Small Cell Lung Cancer 5b. GRANT NUMBER W81XWH-15-2-0063...immune checkpoint inhibitor MPDL3280A (atezolizumab) in early stage inoperable non-small cell lung cancer . The trial is comprised of a traditional 3 + 3

  13. Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals.

    Science.gov (United States)

    Ito, Masataka; Shiba, Rika; Watanabe, Miteki; Iwao, Yasunori; Itai, Shigeru; Noguchi, Shuji

    2018-06-01

    Metastable crystal form I of the antibiotic clarithromycin has a pharmaceutically valuable characteristic that its crystalline phase transition can be applied for its sustained release from tablets. The phase transition of form I was investigated in detail by single crystal and powder X-ray analyses, dynamic vapor sorption analysis and thermal analysis. The single crystal structure of form I revealed that form I was not an anhydrate crystal but contained a partially occupied water molecule in the channel-like void space. Dynamic vapor sorption (DVS) analysis demonstrated that form I crystals reversibly sorbed water molecules in two steps when the relative humidity (RH) increased and finally transited to hydrate form IV at 95% RH. DVS analysis also showed that when the RH decreased form IV crystals lost water molecules at 40% RH and transited to the newly identified anhydrate crystal form VII. Form VII reversibly transited to form IV at lower RH than form I, suggesting that form I is more suitable for manufacturing a sustained-release tablet of CAM utilizing the crystalline phase transition. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Bladder Involvement in Stage I Endometriosis.

    Science.gov (United States)

    Brady, Paula C; Missmer, Stacey A; Laufer, Marc R

    2017-08-01

    Endometriosis-the ectopic implantation of endometrial-like tissue-affects 10% of adolescent females and adults. Bladder involvement, causing dysuria and hematuria, occurs in a very small number of endometriosis patients. The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed stage I endometriosis. Postoperatively, she reported persistent dysuria and passage of tissue in her urine. Cystoscopy showed diffuse erythema; urine cytology revealed glandular and spindle cells suggestive of endometriosis. She was transitioned from oral contraceptives to an intranasal gonadotropin-releasing hormone agonist, with symptom resolution. Intravesicular endometriosis coinciding with stage I disease supports a mechanism of endometriosis dissemination other than direct bladder infiltration. Patients with endometriosis who complain of urinary symptoms warrant assessment, because intravesicular bladder involvement cannot be excluded using pelviscopy. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  15. Feasibility of an Integrated Expert Video Authoring Workstation for Low-Cost Teacher Produced CBI. SBIR Phase I: Final Report.

    Science.gov (United States)

    IntelliSys, Inc., Syracuse, NY.

    This was Phase I of a three-phased project. This phase of the project investigated the feasibility of a computer-based instruction (CBI) workstation, designed for use by teachers of handicapped students within a school structure. This station is to have as a major feature the ability to produce in-house full-motion video using one of the…

  16. Contemporary management of stage I and II seminoma.

    Science.gov (United States)

    Chung, Peter; Warde, Padraig

    2013-10-01

    Seminoma represents about 60 % of all testicular germ cell tumors. At presentation about 80 % of patients have stage I and about 15 % have stage II disease. The last three decades have seen a substantial change in the philosophy of management with the success of surveillance as a strategy to minimize unnecessary treatment, recognition of the late effects of radiation therapy, and the success of cisplatin-based chemotherapy as curative treatment either in the first-line or salvage setting. Overall, in stage I disease where 80-85 % are cured with orchiectomy alone, efforts now are directed at reducing the burden of the disease and its diagnosis on patients with increasing utilization of surveillance and decreased employment of adjuvant therapy. For stage II disease, balancing the relative toxicities of radiation and chemotherapy while avoiding the use of multimodality therapy due to the additive long-term toxicity has become the priority.

  17. Final Technical Report for Phase I Award DE-SC0003559

    Energy Technology Data Exchange (ETDEWEB)

    Blair, Jeff L.; Glenn, Lee J.

    2010-09-28

    The Smart Grid opens the door to the development of many companion technologies which will in turn enable the development of a variety of devices for household electricity-consuming appliances that can communicate with it; especially, many major appliance manufacturers (such as Whirlpool and General Electric) have made public commitments to design their appliances to be Smart Grid-compatible over the next several years. Yet during that same time period, customers will purchase many millions of long-lasting appliances which are not compatible with the Smart Grid. This research project's purpose is to bring significant Smart Grid compatibility to previously-installed appliances that were not specifically designed for any Smart Grid communications, in a way that is both economical and attractive for users who want to share in the energy cost savings and reduction of peak power demand opportunities provided by the evolving Smart Grid infrastructure. The focus of this effort is to identify and research smart control solutions which take advantage of the effective strategies of demand-response (DR) communications from utilities [including time-of-day (TOD) and peak-demand pricing options] and function apart from any need for operational changes to be designed into the non-smart appliances. Our Phase I concepts promote technological advancements for enabling devices that shift the available-use time of millions of different appliances which otherwise have no Smart Grid capability. We researched low-cost microcontroller-based ways of creating devices with the ability to: (1) maintain an accurate time and day (with no need for battery backup throughout a power outage); (2) perform two-way wired and wireless communications directly with the utility company's demand management signals, to identify both low-cost time periods as well as critical-reduction periods when the cost of energy use would otherwise be much higher; (3) measure the power usage of the connected

  18. Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

    Science.gov (United States)

    2017-05-03

    Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

  19. A History of H i Stripping in Virgo: A Phase-space View of VIVA Galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hyein; Chung, Aeree; Smith, Rory [Department of Astronomy, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722 (Korea, Republic of); Jaffé, Yara L., E-mail: hiyoon@galaxy.yonsei.ac.kr, E-mail: achung@yonsei.ac.kr [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago (Chile)

    2017-04-01

    We investigate the orbital histories of Virgo galaxies at various stages of H i gas stripping. In particular, we compare the location of galaxies with different H i morphology in phase space. This method is a great tool for tracing the gas stripping histories of galaxies as they fall into the cluster. Most galaxies at the early stage of H i stripping are found in the first infall region of Virgo, while galaxies undergoing active H i stripping mostly appear to be falling in or moving out near the cluster core for the first time. Galaxies with severely stripped, yet symmetric, H i disks are found in one of two locations. Some are deep inside the cluster, but others are found in the cluster outskirts with low orbital velocities. We suggest that the latter group of galaxies belong to a “backsplash” population. These present the clearest candidates for backsplashed galaxies observationally identified to date. We further investigate the distribution of a large sample of H i-detected galaxies toward Virgo in phase space, confirming that most galaxies are stripped of their gas as they settle into the gravitational potential of the cluster. In addition, we discuss the impact of tidal interactions between galaxies and group preprocessing on the H i properties of the cluster galaxies, and link the associated star formation evolution to the stripping sequence of cluster galaxies.

  20. Surveillance in stage I testicular cancer

    DEFF Research Database (Denmark)

    Daugaard, Gedske; Petersen, Peter Meidahl; Rørth, Mikael

    2003-01-01

    Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29...

  1. Phase I Final Report: Ultra-Low Background Alpha Activity Counter

    International Nuclear Information System (INIS)

    Warburton, W.K.

    2005-01-01

    processor we easily distinguish between these two risetimes and thereby count only alpha particles emitted by the sample. Alpha particles emitted from the sample tray are absorbed in the rear of the sample, so the tray's emissivity does not contribute to the background either. Extensions of the method to the counter's sidewalls similarly allow us to reject alpha particles emitted from the sidewalls. We can thus able obtain background rates over a factor of 1000 lower than in conventional instruments without active background rejection. Extending this principle to count at the 0.00001 alpha/cm 2 /hour, level encounters difficulties because there will typically be only 2.4 alpha particles per square meter per day. Since about 6 counts are required to measure activity at the 95% confidence level, large sample areas are required to make measurements in reasonable times. Unfortunately, increasing the counter's anode area to a square meter raises its capacitance so much that the preamplifier noise levels swamp the alpha particle signals and make counting impossible. In this SBIR we worked to solve this dilemma by segmenting the single large area electrode into several smaller, lower capacitance electrodes that could still detect the alpha particles reliably. Each electrode would have its own electronic and we would capture signals from all of them in coincidence (since an alpha track might well deposit charge on more than one electrode), a technique in which XIA is experienced. Therefore, in Phase I we worked to show proof of principle by subdividing our original 1,800 cm 2 electrode into 4 square segments, each 625 cm 2 and demonstrating that signal noise on individual channels reduced as expected. Because the Phase II counter with a 1 m 2 segmented anode would require 16 segments plus a segmented guard as well, we also designed low cost signal processing electronics to instrument it in Phase II. Our Phase I effort met our major proof of principle goals. In particular, reducing

  2. Understanding cognitive processes behind acceptance or refusal of phase I trials.

    Science.gov (United States)

    Pravettoni, Gabriella; Mazzocco, Ketti; Gorini, Alessandra; Curigliano, Giuseppe

    2016-04-01

    Participation in phase I trials gives patients the chance to obtain control over their disease by trying an experimental therapy. The patients' vulnerability, the informed consent process aiming at understanding the purpose and potential benefits of the phase I trial, and the complexity of the studies may impact the patient's final decision. Emotionally difficult health conditions may induce patients to succumb to cognitive biases, allocating attention only on a part of the provided information. Filling the gap in patients' information process can foster the implementation of strategies to help physicians tailor clinical trials' communication providing personalized support and tailored medical information around patients' need, so avoiding cognitive biases in patients and improving informed shared decision quality. The aim of the present review article focuses on the analysis of cognitive and psychological factors that affect patients' decision to participate or not to early phase clinical trials. Copyright © 2016. Published by Elsevier Ireland Ltd.

  3. Scrubbers: A popular Phase I compliance strategy

    International Nuclear Information System (INIS)

    Fink, C.E.; Bissell, P.E.; Koch, B.J.; Rutledge, G.D.

    1992-01-01

    As utilities commit to compliance plans to meet the Phase I requirements of the Clean Air Act Amendments of 1990, there are indications that scrubbing may account for up to 50 percent of the total SO 2 reductions in Phase I. This paper presents and analyzes the critical reasons that explain how and why scrubber-based compliance strategies have developed into the least-cost option in Phase I for many utilities. A hypothetical utility system was simulated to study the impacts of various technological, legislative, and regulatory issues on compliance decisions and costs. Issues evaluated using the hypothetical system include the emissions cap, Clean Air Act and state incentives to scrub, improvements in scrubber technology and costs, and the integration of Phase I and II compliance strategies by the phased installation of scrubbers. In combination, these considerations increase the attractiveness of scrubbers during the 1995-1999 Phase I period. Other considerations that will ultimately influence the amount of Phase I scrubbing capacity include the additional power generation costs associated with fuel switching, the uncertainty of low-sulfur coal price projections, fuel supply flexibility, scrubber market aspects, and socioeconomic considerations

  4. Parallel tools GUI framework-DOE SBIR phase I final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Galarowicz, James [Argo Navis Technologies LLC., Annapolis, MD (United States)

    2013-12-05

    Many parallel performance, profiling, and debugging tools require a graphical way of displaying the very large datasets typically gathered from high performance computing (HPC) applications. Most tool projects create their graphical user interfaces (GUI) from scratch, many times spending their project resources on simply redeveloping commonly used infrastructure. Our goal was to create a multiplatform GUI framework, based on Nokia/Digia’s popular Qt libraries, which will specifically address the needs of these parallel tools. The Parallel Tools GUI Framework (PTGF) uses a plugin architecture facilitating rapid GUI development and reduced development costs for new and existing tool projects by allowing the reuse of many common GUI elements, called “widgets.” Widgets created include, 2D data visualizations, a source code viewer with syntax highlighting, and integrated help and welcome screens. Application programming interface (API) design was focused on minimizing the time to getting a functional tool working. Having a standard, unified, and userfriendly interface which operates on multiple platforms will benefit HPC application developers by reducing training time and allowing users to move between tools rapidly during a single session. However, Argo Navis Technologies LLC will not be submitting a DOE SBIR Phase II proposal and commercialization plan for the PTGF project. Our preliminary estimates for gross income over the next several years was based upon initial customer interest and income generated by similar projects. Unfortunately, as we further assessed the market during Phase I, we grew to realize that there was not enough demand to warrant such a large investment. While we do find that the project is worth our continued investment of time and money, we do not think it worthy of the DOE's investment at this time. We are grateful that the DOE has afforded us the opportunity to make this assessment, and come to this conclusion.

  5. Final chlorine dioxide stage at near-neutral pH for bleaching eucalypt pulp

    Directory of Open Access Journals (Sweden)

    Robisnéa A. Ribeiro

    2014-01-01

    Full Text Available It is well known that pH is an important parameter for controlling the eucalyptus pulp bleaching when using the final chlorine dioxide stage, since it affects the effectiveness of the process. Recommendations found in the literature for operating are in the 3.5 to 4.0 range. However, in this paper it was shown that final chlorine dioxide has better performance, with significant brightness gain while also preserving pulp quality, when it is operated at near neutral pH. This result can be explained by the generation of sodium bicarbonate in situ upon adding carbon dioxide at this stage.

  6. Catalytic conversion of light alkanes. Final report, January 1, 1990--October 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    During the course of the first three years of the Cooperative Agreement (Phase I-III), we uncovered a family of metal perhaloporphyrin complexes which had unprecedented activity for the selective air-oxidation of fight alkanes to alcohols. The reactivity of fight hydrocarbon substrates with air or oxygen was in the order: isobutane>propane>ethane>methane, in accord with their homolytic bond dissociation energies. Isobutane was so reactive that the proof-of concept stage of a process for producing tert-butyl alcohol from isobutane was begun (Phase V). It was proposed that as more active catalytic systems were developed (Phases IV, VI), propane, then ethane and finally methane oxidations will move into this stage (Phases VII through IX). As of this writing, however, the program has been terminated during the later stages of Phases V and VI so that further work is not anticipated. We made excellent progress during 1994 in generating a class of less costly new materials which have the potential for high catalytic activity. New routes were developed for replacing costly perfluorophenyl groups in the meso-position of metalloporphyrin catalysts with far less expensive and lower molecular weight perfluoromethyl groups.

  7. Daylighting Digital Dimmer SBIR Phase 2 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Morgan [MoJo Labs Inc., Longmont, CO (United States)

    2018-01-17

    The primary focus of the Phase II Development is the implementation of two key technologies, Task To Wall (TTW) Control, and Wand Gesture light dimming control into an easy to use remote for SSL light control, the MoJo Remote. The MoJo Remote product family includes a battery powered wireless remote, a WiFi gateway as well as Mobile Applications for iOS and Android. Specific accomplishments during the second reporting period include: 1. Finalization and implementation of MoJo Remote Accelerometer and capacitive-touch based UI/UX, referred to as the Wand Gesture UI. 2. Issuance of Patent for Wand Gesture UI. 3. Industrial and Mechanical Design for MoJo Remote and MoJo Gateway. 4. Task To Wall implementation and testing in MoJo Remote. 5. Zooming User Interface (ZUI) for the Mobile App implemented on both iOS and Andriod. 6. iOS Mobile app developed to beta level functionality. 7. Initial Development of the Android Mobile Application. 8. Closed loop color control at task (demonstrated at 2016 SSL R&D Workshop). 9. Task To Wall extended to Color Control, working in simulation. 10. Beta testing begun in Late 2017/Early 2018. The MoJo Remote integrates the Patented TTW Control and the Wand Gesture innovative User Interface, and is currently in Beta testing and on the path to commercialization.

  8. Exploring Stage I non-small-cell lung cancer: development of a prognostic model predicting 5-year survival after surgical resection†.

    Science.gov (United States)

    Guerrera, Francesco; Errico, Luca; Evangelista, Andrea; Filosso, Pier Luigi; Ruffini, Enrico; Lisi, Elena; Bora, Giulia; Asteggiano, Elena; Olivetti, Stefania; Lausi, Paolo; Ardissone, Francesco; Oliaro, Alberto

    2015-06-01

    Despite impressive results in diagnosis and treatment of non-small-cell lung cancer (NSCLC), more than 30% of patients with Stage I NSCLC die within 5 years after surgical treatment. Identification of prognostic factors to select patients with a poor prognosis and development of tailored treatment strategies are then advisable. The aim of our study was to design a model able to define prognosis in patients with Stage I NSCLC, submitted to surgery with curative intent. A retrospective analysis of two surgical registries was performed. Predictors of survival were investigated using the Cox model with shared frailty (accounting for the within-centre correlation). Candidate predictors were: age, gender, smoking habit, morbidity, previous malignancy, Eastern Cooperative Oncology Group performance status, clinical N stage, maximum standardized uptake value (SUV(max)), forced expiratory volume in 1 s, carbon monoxide lung diffusion capacity (DLCO), extent of surgical resection, systematic lymphadenectomy, vascular invasion, pathological T stage, histology and histological grading. The final model included predictors with P model demonstrated that mortality was significantly associated with age, male sex, presence of cardiac comorbidities, DLCO (%), SUV(max), systematic nodal dissection, presence of microscopic vascular invasion, pTNM stage and histological grading. The final model showed a fair discrimination ability (C-statistic = 0.69): the calibration of the model indicated a good agreement between observed and predicted survival. We designed an effective prognostic model based on clinical, pathological and surgical covariates. Our preliminary results need to be refined and validated in a larger patient population, in order to provide an easy-to-use prognostic tool for Stage I NSCLC patients. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  9. TREATMENT FOR STAGE I TESTICULAR SEMINOMA

    Directory of Open Access Journals (Sweden)

    E. A. Burova

    2014-07-01

    Full Text Available Overall survival is about 100% in patients with stage I germinogenic testicular tumors after orchifuniculectomy, which is achieved, by applying alternative adjuvant approaches. The use of approaches, such as a follow-up, chemo- and radiotherapy, may be recommended in seminoma. The paper shows the advantages and disadvantages of these methods.

  10. TREATMENT FOR STAGE I TESTICULAR SEMINOMA

    Directory of Open Access Journals (Sweden)

    E. A. Burova

    2010-01-01

    Full Text Available Overall survival is about 100% in patients with stage I germinogenic testicular tumors after orchifuniculectomy, which is achieved, by applying alternative adjuvant approaches. The use of approaches, such as a follow-up, chemo- and radiotherapy, may be recommended in seminoma. The paper shows the advantages and disadvantages of these methods.

  11. Commissioning of the CMS Hadron Forward Calorimeters Phase I Upgrade

    CERN Document Server

    Bilki, Burak

    2017-01-01

    The final phase of the CMS Hadron Forward Calorimeters Phase I upgrade was performed during the Extended Year End Technical Stop of 2016 and 2017. In the framework of the upgrade, the PMT boxes were reworked to implement two channel readout in order to exploit the benefits of the multi-anode PMTs in background tagging and signal recovery. The front-end electronics were also upgraded to QIE10-based electronics which implement larger dynamic range and a 6-bit TDC. Following this major upgrade, the Hadron Forward Calorimeters were commissioned for operation readiness in 2017. Here we describe the details and the components of the upgrade, and discuss the operational experience and results obtained during the upgrade and commissioning.

  12. Commissioning of the CMS Hadron Forward Calorimeters Phase I Upgrade

    Science.gov (United States)

    Bilki, B.; Onel, Y.

    2018-03-01

    The final phase of the CMS Hadron Forward Calorimeters Phase I Upgrade was performed during the Extended Year End Technical Stop of 2016-2017. In the framework of the upgrade, the PMT boxes were reworked to implement two channel readout in order to exploit the benefits of the multi-anode PMTs in background tagging and signal recovery. The front-end electronics were also upgraded to QIE10-based electronics which implement larger dynamic range and a 6-bit TDC. Following this major upgrade, the Hadron Forward Calorimeters were commissioned for operation readiness in 2017. Here we describe the details and the components of the upgrade, and discuss the operational experience and results obtained during the upgrade and commissioning.

  13. Small Business Innovation Research GRC Phase I, Phase II, and Post-Phase II Opportunity Assessment for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    This report outlines the 2015 Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) Phase I, Phase II, and Post-Phase II opportunity contract award results associated with NASA's Aeronautics Research Mission Directorate (ARMD), Human Exploration and Operations Mission Directorate (HEOMD), Science Mission Directorate (SMD), and Space Technology Mission Directorate (STMD) for NASA Glenn Research Center. The report also highlights the number of Phase I, Phase II, and Post-Phase II contracts awarded by mission directorate. The 2015 Phase I contract awards to companies in Ohio and their corresponding technologies are also discussed.

  14. Seismic safety margins research program. Phase I final report - Overview

    International Nuclear Information System (INIS)

    Smith, P.D.; Dong, R.G.; Bernreuter, D.L.; Bohn, M.P.; Chuang, T.Y.; Cummings, G.E.; Johnson, J.J.; Mensing, R.W.; Wells, J.E.

    1981-04-01

    The Seismic Safety Margins Research Program (SSMRP) is a multiyear, multiphase program whose overall objective is to develop improved methods for seismic safety assessments of nuclear power plants, using a probabilistic computational procedure. The program is being carried out at the Lawrence Livermore National Laboratory and is sponsored by the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. Phase I of the SSMRP was successfully completed in January 1981: A probabilistic computational procedure for the seismic risk assessment of nuclear power plants has been developed and demonstrated. The methodology is implemented by three computer programs: HAZARD, which assesses the seismic hazard at a given site, SMACS, which computes in-structure and subsystem seismic responses, and SEISIM, which calculates system failure probabilities and radioactive release probabilities, given (1) the response results of SMACS, (2) a set of event trees, (3) a family of fault trees, (4) a set of structural and component fragility descriptions, and (5) a curve describing the local seismic hazard. The practicality of this methodology was demonstrated by computing preliminary release probabilities for Unit 1 of the Zion Nuclear Power Plant north of Chicago, Illinois. Studies have begun aimed at quantifying the sources of uncertainty in these computations. Numerous side studies were undertaken to examine modeling alternatives, sources of error, and available analysis techniques. Extensive sets of data were amassed and evaluated as part of projects to establish seismic input parameters and to produce the fragility curves. (author)

  15. High Performance Hybrid Upper Stage for NanoLaunch Vehicles, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Parabilis Space Technologies, Inc. (Parabilis), in collaboration with Utah State University (USU), proposes a low cost, high performance launch vehicle upper stage...

  16. HLW Salt Disposition Alternatives Identification Preconceptual Phase I Summary Report (Including Attachments)

    International Nuclear Information System (INIS)

    Piccolo, S.F.

    1999-01-01

    The purpose of this report is to summarize the process used by the Team to systematically develop alternative methods or technologies for final disposition of HLW salt. Additionally, this report summarizes the process utilized to reduce the total list of identified alternatives to an ''initial list'' for further evaluation. This report constitutes completion of the team charter major milestone Phase I Deliverable

  17. Interactions between mobilized radionuclides and secondary phases in final repository-relevant formation aquifers. Final report; Wechselwirkung mobilisierter Radionuklide mit sekundaeren Phasen in endlagerrelevanten Formationswaessern. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Curtius, H.; Kaiser, G.; Paparigas, Z.; Hansen, B.; Neumann, A.; Klinkenberg, M.; Mueller, E.; Bruecher, H.; Bosbach, D.

    2010-10-15

    The report on interactions between mobilized radionuclides and secondary phases in final repository-relevant formation aquifers covers the following issues: scope of study, leaching experiments, secondary phases, incorporation and sorption studies, summary and prospects. The results show that the investigated spent fuels dissolve instantaneously in contact with the repository-relevant aquifers in presence of iron ions. For the elements Cs and Sr no re-immobilization was observed. These elements have to be considered as mobile species in the radionuclide source term. The secondary phases due to corrosion processes are radionuclide sinks, i.e. actinides are re-immobilized, the retention mechanisms were clarified. The studies with irradiated nuclear fuel show that the uranium/silicon containing phases effect the molar solubility of actinides.

  18. A two-phase inspection model for a single component system with three-stage degradation

    International Nuclear Information System (INIS)

    Wang, Huiying; Wang, Wenbin; Peng, Rui

    2017-01-01

    This paper presents a two-phase inspection schedule and an age-based replacement policy for a single plant item contingent on a three-stage degradation process. The two phase inspection schedule can be observed in practice. The three stages are defined as the normal working stage, low-grade defective stage and critical defective stage. When an inspection detects that an item is in the low-grade defective stage, we may delay the preventive replacement action if the time to the age-based replacement is less than or equal to a threshold level. However, if it is above this threshold level, the item will be replaced immediately. If the item is found in the critical defective stage, it is replaced immediately. A hybrid bee colony algorithm is developed to find the optimal solution for the proposed model which has multiple decision variables. A numerical example is conducted to show the efficiency of this algorithm, and simulations are conducted to verify the correctness of the model. - Highlights: • A two-phase inspection model is studied. • The failure process has three stages. • The delayed replacement is considered.

  19. Automated System for Aneuploidy Detection in Sperm Final Report CRADA No. TC-1364-96: Phase I SBIR

    Energy Technology Data Exchange (ETDEWEB)

    Wyrobek, A. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dunlay, R. T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-10-19

    This project was a relationship between Lawrence Livermore National Laboratory (LLNL) and Biological Detection, Inc. (now known as Cellomics, Inc.) It was funded as a Phase I SBIR from the National Institutes of Health (NIH) awarded to Cellomics, Inc. with a subcontract to LLNL.

  20. Comparison of single-stage and temperature-phased two-stage anaerobic digestion of oily food waste

    International Nuclear Information System (INIS)

    Wu, Li-Jie; Kobayashi, Takuro; Li, Yu-You; Xu, Kai-Qin

    2015-01-01

    Highlights: • A single-stage and two two-stage anaerobic systems were synchronously operated. • Similar methane production 0.44 L/g VS_a_d_d_e_d from oily food waste was achieved. • The first stage of the two-stage process became inefficient due to serious pH drop. • Recycle favored the hythan production in the two-stage digestion. • The conversion of unsaturated fatty acids was enhanced by recycle introduction. - Abstract: Anaerobic digestion is an effective technology to recover energy from oily food waste. A single-stage system and temperature-phased two-stage systems with and without recycle for anaerobic digestion of oily food waste were constructed to compare the operation performances. The synchronous operation indicated the similar ability to produce methane in the three systems, with a methane yield of 0.44 L/g VS_a_d_d_e_d. The pH drop to less than 4.0 in the first stage of two-stage system without recycle resulted in poor hydrolysis, and methane or hydrogen was not produced in this stage. Alkalinity supplement from the second stage of two-stage system with recycle improved pH in the first stage to 5.4. Consequently, 35.3% of the particulate COD in the influent was reduced in the first stage of two-stage system with recycle according to a COD mass balance, and hydrogen was produced with a percentage of 31.7%, accordingly. Similar solids and organic matter were removed in the single-stage system and two-stage system without recycle. More lipid degradation and the conversion of long-chain fatty acids were achieved in the single-stage system. Recycling was proved to be effective in promoting the conversion of unsaturated long-chain fatty acids into saturated fatty acids in the two-stage system.

  1. Fossil fuel derivatives with reduced carbon. Phase I final report

    Energy Technology Data Exchange (ETDEWEB)

    Kennel, E.B.; Zondlo, J.W.; Cessna, T.J.

    1999-06-30

    This project involves the simultaneous production of clean fossil fuel derivatives with reduced carbon and sulfur, along with value-added carbon nanofibers. This can be accomplished because the nanofiber production process removes carbon via a catalyzed pyrolysis reaction, which also has the effect of removing 99.9% of the sulfur, which is trapped in the nanofibers. The reaction is mildly endothermic, meaning that net energy production with real reductions in greenhouse emissions are possible. In Phase I research, the feasibility of generating clean fossil fuel derivatives with reduced carbon was demonstrated by the successful design, construction and operation of a facility capable of utilizing coal as well as natural gas as an inlet feedstock. In the case of coal, for example, reductions in CO{sub 2} emissions can be as much as 70% (normalized according to kilowatts produced), with the majority of carbon safely sequestered in the form of carbon nanofibers or coke. Both of these products are value-added commodities, indicating that low-emission coal fuel can be done at a profit rather than a loss as is the case with most clean-up schemes. The main results of this project were as follows: (1) It was shown that the nanofiber production process produces hydrogen as a byproduct. (2) The hydrogen, or hydrogen-rich hydrocarbon mixture can be consumed with net release of enthalpy. (3) The greenhouse gas emissions from both coal and natural gas are significantly reduced. Because coal consumption also creates coke, the carbon emission can be reduced by 75% per kilowatt-hour of power produced.

  2. Use of spiral CT in demonstrating early carcinoma of the stomach - I stage

    International Nuclear Information System (INIS)

    Pomakov, P.

    2009-01-01

    Full text: The aim of this lecture is to provide practical information about the methodology and technique of spiral computed tomography, which provide maximum diagnostic efficiency in early gastric cancer - I stage, and to present the semiotics of CT images seen in early gastric cancer stage I - a own and literature data. Methodology of the study covers optimal drug muscle relaxation of the abdominal wall by injection of 2 sg buskolizin intravenous; maximum distension of the stomach lumen by ingestion of 3 effervescent disintegrated tablets Vit. C with 1-2 sips of water, necessarily using of non-ionic contrast media - 100 ml / 300 mg iodine / 1 ml liquid bolus introduced for 30 seconds. Start scanning - 30 seconds of the start of injection - to visualize the arterial phase, use of slices with a thickness of 3 mm and 2 mm interval; exponential data 120 kV, 160 mAc. Earlier form of gastric cancer have to be presented by 5 CT image: unequal unsmooth, scallop or polycyclic contours of the lining, thinning the complete disappearance of the lining; undulating thickening of the lining; nodal formation like a polyp on a broad basis with a 2-5 mm, double contour of the lining - like a wave. These amendments are localized only in a limited segment of the gastric mucosa. Spiral CT is an effective diagnostic performance in gastric cancer, including the early stage I of cancer development. This is realized only by using the specific methodology of the study as well as good knowledge of the CT images semiology for carcinoma, localized only within a certain perimeter of the stomach lining

  3. Photovoltaic Wire, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will investigate a new architecture for photovoltaic devices based on nanotechnology: photovoltaic wire. The...

  4. Population-based treatment and outcomes of Stage I uterine serous carcinoma

    NARCIS (Netherlands)

    Putten, L.J.M. van der; Hoskins, P.; Tinker, A.; Lim, P.; Aquino-Parsons, C.; Kwon, J.S.

    2014-01-01

    OBJECTIVE: Uterine serous carcinoma (USC) is a rare type of endometrial cancer that often recurs in patients with Stage I disease. Our objective was to evaluate treatment and outcomes in Stage I USC in the context of a population-based study. METHODS: This was a population-based retrospective cohort

  5. Surveillance for stage I nonseminoma testicular cancer

    DEFF Research Database (Denmark)

    Daugaard, Gedske; Gundgaard, Maria Gry; Mortensen, Mette Saksø

    2014-01-01

    PURPOSE: To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. PATIENTS AND METHODS: From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion......, were observed in a surveillance program. RESULTS: The relapse rate after orchiectomy alone was 30.6% at 5 years. Presence of vascular invasion together with embryonal carcinoma and rete testis invasion in the testicular primary identified a group with a relapse risk of 50%. Without risk factors....... Relapses after 5 years were seen in 0.5% of the whole cohort or in 1.6% of relapsing patients. The majority of relapses (94.4%) belonged to the good prognostic group according to the International Germ Cell Cancer Collaborative Group classification. The disease-specific survival at 15 years was 99...

  6. Final stage of high energy hadron-nucleus nuclear collision reactions

    International Nuclear Information System (INIS)

    Strugal'ski, Z.; Jedrzejec, H.; Strugalska-Gola, E.; Mulas, E.

    1996-01-01

    The final or 'slow' stage of the hadron-nucleus collision reactions at high energy is considered on the basis of the collision mechanism prompted experimentally. The transmutation process of the damaged target nucleus into nucleons and stable nuclear fragments is discussed. Relations between intensities or multiplicities n p of the emitted fast protons and the mean intensities or multiplicities b > of the evaporated nucleons and nuclear fragments are presented. 14 refs

  7. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  8. Design of 12-phase, 2-stage Harmonic Rejection Mixer for TV Tuners

    Directory of Open Access Journals (Sweden)

    D. Lee

    2016-06-01

    Full Text Available A two-stage 12-phase harmonic rejection mixer (HRM for TV tuners is proposed in order to reject the local oscillator (LO harmonics up to the ninth order. The proposed weighing scheme for 12-phase, 2-stage harmonic mixing can reduce the harmonic rejection (HR sensitivity to the amplitude error caused by irrational numbers such as . To verify this HR, the 2-stage HR circuit is designed with baseband gm weighting in order to save power and improve the HR ratios without calibration. The proposed HRM achieves the third to ninth worst HR ratios, more than 55 dB, according to Monte Carlo simulations. It consumes 6.5 mA under a 2.5 V supply voltage.

  9. Phase I trial of concurrent chemoradiotherapy for laryngeal and hypopharyngeal cancers with bi-weekly docetaxel

    International Nuclear Information System (INIS)

    Yoshida, Tomoyuki; Nakamura, Kazuhiro; Simizu, Shigetaka

    2005-01-01

    Docetaxel (DOC) has radiation-sensitizing effects because it synchronizes with the most radiation-sensitive G2/M phase of the cell cycle. From the results of concurrent radiotherapy with weekly DOC administrations in a phase I trial, dose-limiting toxicity (DLT) was mucositis and the recommended dose was 10 mg/m 2 , but the administration schedule was a problem. We planned concurrent radiation therapy in a bi-weekly DOC phase I trial to improve the larynx preservation rate and to determine which schedule and dosage of DOC would yield its inherent cytotoxic effects. We decided the maximum tolerated dose (MTD) and DLT to serve as an index of the appearance of adverse events. Patients with stage II or stage III T2N1 hypopharyngeal cancer or stage II or III laryngeal cancer were included in this study. DOC was administered on the days of initiation of bi-weekly radiation (day 1, day 15, day 29). Radiation was given (2 Gy/day: 5 days per week) for a total of 30 Fr, with a total of 60 Gy. The starting dose of DOC was 30 mg/m 2 (level 1) and the dosage was raised by 5 mg/m 2 at each level. DLT was observed due to mucositis and neutropenia at 40 mg/m 2 (level 3), the MTD was 40 mg/m 2 and the recommended dose (RD) was 35 mg/m 2 . Especially in hypopharyngeal cancer of Grade 3 or more, mucositis appeared, with swallowing difficulty in cases with a wide range of irradiation. At dosages of 35 mg/m 2 , the effectiveness was favorable and this was the suitable dosage recommended for the subsequent phase II trial. This clinical study was performed with permission of our IRB (Institutional Review Board). (author)

  10. Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

    Science.gov (United States)

    2014-11-07

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage

  11. Microstructure and mechanical properties of Mg-Zn-Y alloy containing LPSO phase and I-phase

    Science.gov (United States)

    Ye, Zhijian; Teng, Xinying; Lou, Gui; Zhou, Guorong; Leng, Jinfeng

    2017-08-01

    Microstructure and mechanical properties of Mg-Zn-Y alloy including LPSO phase and I-phase was investigated. Transmission electron microscopy, x-ray diffraction analysis and differential scanning calorimeter analysis reveal that the LPSO (long period stacking ordered structure) phase and I-phase can co-exist within the α-Mg matrix. Wherein, the quasicrystal phases exist in the (I-phase  +  α-Mg) eutectic structures. In the Mg-Zn-Y alloy, it is also found that 14 H type LPSO phases consist of LPSO phase and I-phase. With the addition of quasicrystal master alloy content, the microstructures are refined, and the mechanical properties are enhanced.

  12. Phase I remedial action of properties associated with the former Middlesex Sampling Plant Site

    International Nuclear Information System (INIS)

    1982-04-01

    The Phase I Remedial Action Work on properties associated with the Middlesex Sampling Plant Site in Middlesex, New Jersey was completed during 1980. In addition to the two properties included in the original scope of work, three other properties were decontaminated. In the playground across the street from the Rectory, contaminated soil was discovered and subsequently removed. Later, at the request of the DOE, the Kays and Rosamilia properties were decontaminated. Decontamination of the properties included in Phase I has, in the judgment of NLO, been successfully achieved, as evidenced by the data presented in this and in the referenced Eberline Instrument Corporation reports. Final certification of the sites for unrestricted use will be by ASEP/OOS based upon all available data, of which this report is a part. Work completed at Middlesex, together with the lessons learned during the execution of the entire project, is indicative that future decontamination assignments can be accomplished with mutual benefits for the DOE, as well as the local citizens. Restoration of the Rectory and the William Street property exemplifies the excellence of work performed by the Remedial Action Subcontractors and is further evidence of the success of the Phase I work. A summary of the Phase I costs are tabulated

  13. Phase I/II trial of concurrent use of S-1 and radiation therapy for T2 glottic cancer

    International Nuclear Information System (INIS)

    Nakayama, Meijin; Hayakawa, Kazushige; Okamoto, Makito; Niibe, Yuzuru; Ishiyama, Hiromichi; Kotani, Shouko

    2010-01-01

    A Phase I/II study of S-1 combined radiation therapy was conducted in patients with Stage II (T2N0) glottic cancer. The purpose of the Phase I study was to identify the maximum tolerated dose, the recommended dose and the dose limiting toxicity. The objectives in the phase II study were to estimate the local control and the overall survival, and the incidence of adverse events. In Phase I, S-1 was administered orally in a split-course fashion as two doses of 40 mg/m 2 , for a total daily dose of 80 mg/m 2 . The course involved a 2-week rest after a 2-week administration (Level 1) and a 1-week rest after a 3-week administration (Level 2). Radiation therapy was administered in 2-Gy daily (total 60-Gy) standard fractionation. Seven patients were enrolled in the Phase I, and 19 in the Phase II study. Mucositis was the most common toxicity encountered. All 26 patients completed radiation therapy without delay. The overall response rate was 100% (26/26) with all patients showing a complete response. One patient developed a local recurrence 28 months after the treatment. The 3-year local control and overall survival rates were 94.7 and 85.4%, respectively (limited to 22 patients from Level 2). The use of S-1 at 80 mg/m 2 per day in a split-course with 1-week rest during the course of radiation therapy was safe and effective for Stage II glottic cancer. The treatment strategy employing orally available S-1 proved to be beneficial over the conventional injection of antitumor agents for maintaining the patients' quality of life. (author)

  14. PHASE ANALYSES OF URANIUM BEARING MINERALS FROM THE HIGH GRADE ORE, NOPAL I, PENA BLANCA, MEXICO

    International Nuclear Information System (INIS)

    Ren, M.; Goodell, P.; Kelts, A.; Anthony, E.Y.; Fayek, M.; Fan, C.; Beshears, C.

    2005-01-01

    The Nopal I uranium deposit is located in the Pena Blanca district, approximately 40 miles north of Chihuahua City, Mexico. The deposit was formed by hydrothermal processes within the fracture zone of welded silicic volcanic tuff. The ages of volcanic formations are between 35 to 44 m.y. and there was secondary silicification of most of the formations. After the formation of at least part of the uranium deposit, the ore body was uplifted above the water table and is presently exposed at the surface. Detailed petrographic characterization, electron microprobe backscatter electron (BSE) imagery, and selected x-ray maps for the samples from Nopal I high-grade ore document different uranium phases in the ore. There are at least two stages of uranium precipitation. A small amount of uraninite is encapsulated in silica. Hexavalent uranium may also have been a primary precipitant. The uranium phases were precipitated along cleavages of feldspars, and along fractures in the tuff. Energy dispersive spectrometer data and x-ray maps suggest that the major uranium phases are uranophane and weeksite. Substitutions of Ca and K occur in both phases, implying that conditions were variable during the mineralization/alteration process, and that compositions of the original minerals have a major influence on later stage alteration. Continued study is needed to fully characterize uranium behavior in these semi-arid to arid conditions

  15. PHASE ANALYSES OF URANIUM-BEARING MINERALS FROM THE HIGH GRADE ORE, NOPAL I, PENA BLANCA, MEXICO

    Energy Technology Data Exchange (ETDEWEB)

    M. Ren; P. Goodell; A. Kelts; E.Y. Anthony; M. Fayek; C. Fan; C. Beshears

    2005-07-11

    The Nopal I uranium deposit is located in the Pena Blanca district, approximately 40 miles north of Chihuahua City, Mexico. The deposit was formed by hydrothermal processes within the fracture zone of welded silicic volcanic tuff. The ages of volcanic formations are between 35 to 44 m.y. and there was secondary silicification of most of the formations. After the formation of at least part of the uranium deposit, the ore body was uplifted above the water table and is presently exposed at the surface. Detailed petrographic characterization, electron microprobe backscatter electron (BSE) imagery, and selected x-ray maps for the samples from Nopal I high-grade ore document different uranium phases in the ore. There are at least two stages of uranium precipitation. A small amount of uraninite is encapsulated in silica. Hexavalent uranium may also have been a primary precipitant. The uranium phases were precipitated along cleavages of feldspars, and along fractures in the tuff. Energy dispersive spectrometer data and x-ray maps suggest that the major uranium phases are uranophane and weeksite. Substitutions of Ca and K occur in both phases, implying that conditions were variable during the mineralization/alteration process, and that compositions of the original minerals have a major influence on later stage alteration. Continued study is needed to fully characterize uranium behavior in these semi-arid to arid conditions.

  16. Central interstate low-level radioactive waste compact region site exclusionary screening study. Phase I. Final report

    International Nuclear Information System (INIS)

    1985-06-01

    The Low-Level Radioactive Waste Policy Act of 1980 assigns to the states the responsibility for disposal of the low-level radioactive waste generated within their boundaries. It also provides for regional compacts among states to address their needs on a broader basis and permits restriction of the use of regional disposal facilities after January 1, 1986, to generators of low-level waste within the region. Each state, either individually or as a member of a compact, must therefore consider the establishment of a low-level radioactive waste disposal facility within its borders. The states of Arkansas, Kansas, Louisiana, Nebraska, and Oklahoma adopted the Central Interstate Low-Level Waste Compact (CILLWC) and legislation was submitted to Congress for consent in June of 1983 legislation is being reintroduced in the 99th Congress. In August of 1984, the CILLWC selected and contracted Dames and Moore to conduct a Phase I-Site Suitability Screening Study for a low-level radioactive waste disposal facility in the five-state region. This report presents the results of the Phase I Screening Study. Dames and Moore reported to the Technical Advisory Committee (TAC) of the CILLWC which provided guidance and comment on work progress and direction

  17. Investigation of Power Losses of Two-Stage Two-Phase Converter with Two-Phase Motor

    Directory of Open Access Journals (Sweden)

    Michal Prazenica

    2011-01-01

    Full Text Available The paper deals with determination of losses of two-stage power electronic system with two-phase variable orthogonal output. The simulation is focused on the investigation of losses in the converter during one period in steady-state operation. Modeling and simulation of two matrix converters with R-L load is shown in the paper. The simulation results confirm a very good time-waveform of the phase current and the system seems to be suitable for low-cost application in automotive/aerospace industries and in application with high frequency voltage sources.

  18. Commissioning of the CMS Hadron Forward Calorimeters Phase I Upgrade

    CERN Document Server

    Bilki, Burak

    2017-01-01

    The final phase of the CMS Hadron Forward Calorimeters Phase I upgrade is being performed during the Extended Year End Technical Stop of 2016 â?? 2017. In the framework of the upgrade, the PMT boxes are being reworked to implement two channel readout in order to exploit the benefits of the multi-anode PMTs in background tagging and signal recovery. The front-end electronics is also being upgraded to QIE10-based electronics which will implement larger dynamic range and a 6-bit TDC to eliminate the background to have an effect on the trigger. Following this major upgrade, the Hadron Forward Calorimeters will be commissioned for operation readiness in 2017. Here we describe the details and the components of the upgrade, and discuss the operational experience and results obtained during the upgrade and commissioning.

  19. Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer

    International Nuclear Information System (INIS)

    Solhjem, Matthew C.; Petersen, Ivy A.; Haddock, Michael G.

    2005-01-01

    Purpose To determine the efficacy and complications of adjuvant vaginal high-dose-rate brachytherapy alone for patients with Stage I endometrial cancer in whom complete surgical staging had been performed. Methods and Materials Between April 1998 and March 2004, 100 patients with Stage I endometrial cancer underwent surgical staging (total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic ± paraaortic nodal sampling) and postoperative vaginal high-dose-rate brachytherapy at our institution. The total dose was 2100 cGy in three fractions. Results With a median follow-up of 23 months (range 2-62), no pelvic or vaginal recurrences developed. All patients underwent pelvic dissection, and 42% underwent paraaortic nodal dissection. A median of 29.5 pelvic nodes (range 1-67) was removed (84% had >10 pelvic nodes removed). Most patients (73%) had endometrioid (or unspecified) adenocarcinoma, 16% had papillary serous carcinoma, and 11% had other histologic types. The International Federation of Gynecology and Obstetrics stage and grade was Stage IA, grade III in 5; Stage IB, grade I, II, or III in 6, 27, or 20, respectively; and Stage IC, grade I, II, or III in 13, 17, or 10, respectively. The Common Toxicity Criteria (version 2.0) complications were mild (Grade 1-2) and consisted primarily of vaginal mucosal changes, temporary urinary irritation, and temporary diarrhea. Conclusion Adjuvant vaginal high-dose-rate brachytherapy alone may be a safe and effective alternative to pelvic external beam radiotherapy for surgical Stage I endometrial cancer

  20. Final Report SBIR Phase I, Improvement of Properties of Tubular Internal-Tin Nb3Sn

    International Nuclear Information System (INIS)

    Gregory, Eric

    2009-01-01

    Final report of SBIR to develop an economical process that can produce the best material for high field magnets to be used in the next generation of accelerators. The overall problem is to develop an economical process that can produce material with good properties for high field magnets to be used in the future for High Energy Physics (HEP) applications. The Internal-tin (IT) process, called by some the Restacked Rod process (RRP), for making Nb 3 Sn has been very successful in achieving high J c properties in the high field region. As a result it has been used effectively in several high field magnets. Originally, when this material was processed to give the highest J c it behaved unstably in the low field region and consequently did not perform as well in magnets designed for intermediate field applications. In this field range, the Powder-in-Tube (PIT) material, that has a lower d eff and a high RRR, behaved more reliably. The IT material has been improved to give better stability in the low field range and consequently the process offers a considerable challenge to the PIT process for application in both types of magnets. The PIT material has two principal drawbacks - lower J c and high cost. Work has been carried out to address these two problems and Supergenics I LLC has reported, on a low cost tubular process that is under development. It has fewer problems than the (IT) process in making low d eff materials and is of lower cost than both the IT and PIT processes. At the present stage, the J c 's that have been achieved are similar to those of the PIT material but are below those of the IT material. The purpose of the work proposed here is to improve the properties of the material made by this tubular process that has been described previously.

  1. Lymphadenectomy in surgical stage I epithelial ovarian cancer

    DEFF Research Database (Denmark)

    Svolgaard, Olivia; Lidegaard, Ojvind; Nielsen, Marie Louise S

    2014-01-01

    OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated. DESIGN: A prospective nationwide case-only study. SETTING: Denmark...... 2005-2011. SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I). METHOD......: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database. MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups. RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified...

  2. Steam generator tube integrity program: Phase II, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

    1988-08-01

    The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted.

  3. Steam generator tube integrity program: Phase II, Final report

    International Nuclear Information System (INIS)

    Kurtz, R.J.; Bickford, R.L.; Clark, R.A.; Morris, C.J.; Simonen, F.A.; Wheeler, K.R.

    1988-08-01

    The Steam Generator Tube Integrity Program (SGTIP) was a three phase program conducted for the US Nuclear Regulatory Commission (NRC) by Pacific Northwest Laboratory (PNL). The first phase involved burst and collapse testing of typical steam generator tubing with machined defects. The second phase of the SGTIP continued the integrity testing work of Phase I, but tube specimens were degraded by chemical means rather than machining methods. The third phase of the program used a removed-from-service steam generator as a test bed for investigating the reliability and effectiveness of in-service nondestructive eddy-current inspection methods and as a source of service degraded tubes for validating the Phase I and Phase II data on tube integrity. This report describes the results of Phase II of the SGTIP. The object of this effort included burst and collapse testing of chemically defected pressurized water reactor (PWR) steam generator tubing to validate empirical equations of remaining tube integrity developed during Phase I. Three types of defect geometries were investigated: stress corrosion cracking (SCC), uniform thinning and elliptical wastage. In addition, a review of the publicly available leak rate data for steam generator tubes with axial and circumferential SCC and a comparison with an analytical leak rate model is presented. Lastly, nondestructive eddy-current (EC) measurements to determine accuracy of defect depth sizing using conventional and alternate standards is described. To supplement the laboratory EC data and obtain an estimate of EC capability to detect and size SCC, a mini-round robin test utilizing several firms that routinely perform in-service inspections was conducted

  4. Agil Stage-Gate®: ny model for udviklingsprojekter i mellemstore virksomheder

    DEFF Research Database (Denmark)

    Vedsmand, Tomas; Edwards, Kasper; Hvidt, Nicoline

    Lær at udvikle nye produkter hurtigere og med større træfsikkerhed – ved at arbejde i sprint med agile metoder og træffe de rigtige beslutninger med Stage-Gate® Se også tilhørende: "Værktøjskasse til Agil Stage-Gate®: Ny model for udviklingsprojekter i mellemstore virksomheder" på http://dx.doi.org...

  5. Final report on the surface-based investigation phase (phase 1) at the Mizunami Underground Research Laboratory project

    International Nuclear Information System (INIS)

    Saegusa, Hiromitsu; Matsuoka, Toshiyuki

    2011-03-01

    The Mizunami Underground Research Laboratory (MIU) Project is a comprehensive research project investigating the deep underground environment within crystalline rock being conducted by Japan Atomic Energy Agency at Mizunami City in Gifu Prefecture, central Japan and its role is defined in 'Framework for Nuclear Energy Policy' by Japan Atomic Energy Commission. The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering for deep underground application. During Phase I, the overall project goals were supported by Phase I goals. For the overall project goals 1), the Phase I goals were set to construct models of the geological environment from all surface-based investigation results that describe the geological environment prior to excavation and predict excavation response. For the overall project goals 2), the Phase I goals were set to formulate detailed design concepts and a construction plan for the underground facilities. This report summarizes the Phase I investigation which was completed in March 2005. The authors believe this report will make an important milestone, since this report clarifies how the Phase I goals are achieved and evaluate the future issues thereby direct the research which will be conducted during Phase II. With regard to the overall project goals 1), 'To establish techniques for investigation, analysis and assessment of the deep geological environment,' a step-wise investigation was conducted by iterating investigation, interpretation, and assessment, thereby understanding of geologic environment was progressively and effectively improved with progress of investigation. An optimal

  6. NPP A-1 decommissioning - Phase I

    International Nuclear Information System (INIS)

    Krstenik, A.; Blazek, J.

    2000-01-01

    Nuclear power plant A-1 with output 150 MW e , with metallic natural uranium fuelled, CO 2 cooled and heavy water moderated reactor had been prematurely finally shut down in 1977. It is necessary to mention that neither operator nor regulatory and other authorities have been prepared for the solution of such situation. During next two consecutive years after shutdown main effort of operator focused on technical and administrative activities which are described in the previous paper together with approach, condition and constraints for NPP A-1 decommissioning as well as the work and research carried out up to the development and approval of the Project for NPP A-1 decommissioning - I. phase. Subject of this paper is description of: (1) An approach to NPP A -1 decommissioning; (2) An approach to development of the project for NPP A-1 decommissioning; (3) Project - tasks, scope, objectives; (4) Mode of the Project realisation; (5) Progress achieved up to the 1999 year. (authors)

  7. SPIRIT: A seamless phase I/II randomized design for immunotherapy trials.

    Science.gov (United States)

    Guo, Beibei; Li, Daniel; Yuan, Ying

    2018-06-07

    Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses. Toxicity is monitored throughout the trial. The design consists of two seamlessly connected stages. The first stage identifies a set of safe doses. The second stage adaptively randomizes patients to the safe doses identified and uses their progression-free survival and immune response to find the OBD. The simulation study shows that the SPIRIT has desirable operating characteristics and outperforms the conventional design. Copyright © 2018 John Wiley & Sons, Ltd.

  8. Service water system aging assessment - Phase I

    International Nuclear Information System (INIS)

    Jarrell, D.B.; Zimmerman, P.W.; Gore, M.L.

    1988-01-01

    The Service Water System (SWS) represents the final heat transfer loop between decay heat generated in the nuclear core and the safe dispersal of that heat energy in the environment. It is the objective of this investigation to demonstrate that aging phenomena can be identified and quantified such that aging degradation of system components can be detected and mitigated prior to the reduction of system availability to below an acceptable threshold. The approach used during the Phase I task was to (1) perform a literature search of government and private sector reports which relate to service water, aging related degradation, and potential methodologies for analysis; (2) assemble a data base which contains all the commercial power plants in the US, their Service Water System configuration, characteristics, and water source; (3) obtain and examine the available service water data from large generic data bases, i.e. NPRDS, LER, NPE, inspection reports, and other relevant plant reference data; (4) perform a fault tree analysis of a typical plant service water systems to examine failure propagation and understand specific input requirements of probabilistic risk analyses; (5) develop an in-depth questionnaire protocol for examining the information resource at a power plant which is not available through data base query and visit a central station power plant and solicit the required information; (6) analyze the information obtained from the in-depth plant interrogation and draw contrasts and conclusions with the data base information; (7) utilize the plant information to perform an interim assessment of service water system degradation mechanisms and focus future investigations. This paper addresses the elements of this task plan numbered 1, 3, 6, and 7. The remaining items are detailed in the phase-I report

  9. Ocean thermal energy conversion power system development-I. Phase I. Preliminary design report. Volume 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-18

    The results of a conceptual and preliminary design study of Ocean Thermal Energy Conversion (OTEC) closed loop ammonia power system modules performed by Lockheed Missiles and Space Company, Inc. (LMSC) are presented. This design study is the second of 3 tasks in Phase I of the Power System Development-I Project. The Task 2 objectives were to develop: 1) conceptual designs for a 40 to 50-MW(e) closed cycle ammonia commercial plant size power module whose heat exchangers are immersed in seawater and whose ancillary equipments are in a shirt sleeve environment; preliminary designs for a modular application power system sized at 10-MW(e) whose design, construction and material selection is analogous to the 50 MW(e) module, except that titanium tubes are to be used in the heat exchangers; and 3) preliminary designs for heat exchanger test articles (evaporator and condenser) representative of the 50-MW(e) heat exchangers using aluminum alloy, suitable for seawater service, for testing on OTEC-1. The reference ocean platform was specified by DOE as a surface vessel with the heat exchanger immersed in seawater to a design depth of 0 to 20 ft measured from the top of the heat exchanger. For the 50-MW(e) module, the OTEC 400-MW(e) Plant Ship, defined in the Platform Configuration and Integration study, was used as the reference platform. System design, performance, and cost are presented. (WHK)

  10. INL Results for Phases I and III of the OECD/NEA MHTGR-350 Benchmark

    Energy Technology Data Exchange (ETDEWEB)

    Gerhard Strydom; Javier Ortensi; Sonat Sen; Hans Hammer

    2013-09-01

    The Idaho National Laboratory (INL) Very High Temperature Reactor (VHTR) Technology Development Office (TDO) Methods Core Simulation group led the construction of the Organization for Economic Cooperation and Development (OECD) Modular High Temperature Reactor (MHTGR) 350 MW benchmark for comparing and evaluating prismatic VHTR analysis codes. The benchmark is sponsored by the OECD's Nuclear Energy Agency (NEA), and the project will yield a set of reference steady-state, transient, and lattice depletion problems that can be used by the Department of Energy (DOE), the Nuclear Regulatory Commission (NRC), and vendors to assess their code suits. The Methods group is responsible for defining the benchmark specifications, leading the data collection and comparison activities, and chairing the annual technical workshops. This report summarizes the latest INL results for Phase I (steady state) and Phase III (lattice depletion) of the benchmark. The INSTANT, Pronghorn and RattleSnake codes were used for the standalone core neutronics modeling of Exercise 1, and the results obtained from these codes are compared in Section 4. Exercise 2 of Phase I requires the standalone steady-state thermal fluids modeling of the MHTGR-350 design, and the results for the systems code RELAP5-3D are discussed in Section 5. The coupled neutronics and thermal fluids steady-state solution for Exercise 3 are reported in Section 6, utilizing the newly developed Parallel and Highly Innovative Simulation for INL Code System (PHISICS)/RELAP5-3D code suit. Finally, the lattice depletion models and results obtained for Phase III are compared in Section 7. The MHTGR-350 benchmark proved to be a challenging simulation set of problems to model accurately, and even with the simplifications introduced in the benchmark specification this activity is an important step in the code-to-code verification of modern prismatic VHTR codes. A final OECD/NEA comparison report will compare the Phase I and III

  11. Multi-stage phase retrieval algorithm based upon the gyrator transform.

    Science.gov (United States)

    Rodrigo, José A; Duadi, Hamootal; Alieva, Tatiana; Zalevsky, Zeev

    2010-01-18

    The gyrator transform is a useful tool for optical information processing applications. In this work we propose a multi-stage phase retrieval approach based on this operation as well as on the well-known Gerchberg-Saxton algorithm. It results in an iterative algorithm able to retrieve the phase information using several measurements of the gyrator transform power spectrum. The viability and performance of the proposed algorithm is demonstrated by means of several numerical simulations and experimental results.

  12. Multi-stage phase retrieval algorithm based upon the gyrator transform

    OpenAIRE

    Rodrigo Martín-Romo, José Augusto; Duadi, Hamootal; Alieva, Tatiana Krasheninnikova; Zalevsky, Zeev

    2010-01-01

    The gyrator transform is a useful tool for optical information processing applications. In this work we propose a multi-stage phase retrieval approach based on this operation as well as on the well-known Gerchberg-Saxton algorithm. It results in an iterative algorithm able to retrieve the phase information using several measurements of the gyrator transform power spectrum. The viability and performance of the proposed algorithm is demonstrated by means of several numerical simulations and exp...

  13. Phase II Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Schuknecht, Nate [Project Manager; White, David [Principle Investigator; Hoste, Graeme [Research Engineer

    2014-09-11

    The SkyTrough DSP will advance the state-of-the-art in parabolic troughs for utility applications, with a larger aperture, higher operating temperature, and lower cost. The goal of this project was to develop a parabolic trough collector that enables solar electricity generation in the 2020 marketplace for a 216MWe nameplate baseload power plant. This plant requires an LCOE of 9¢/kWhe, given a capacity factor of 75%, a fossil fuel limit of 15%, a fossil fuel cost of $6.75/MMBtu, $25.00/kWht thermal storage cost, and a domestic installation corresponding to Daggett, CA. The result of our optimization was a trough design of larger aperture and operating temperature than has been fielded in large, utility scale parabolic trough applications: 7.6m width x 150m SCA length (1,118m2 aperture), with four 90mm diameter × 4.7m receivers per mirror module and an operating temperature of 500°C. The results from physical modeling in the System Advisory Model indicate that, for a capacity factor of 75%: The LCOE will be 8.87¢/kWhe. SkyFuel examined the design of almost every parabolic trough component from a perspective of load and performance at aperture areas from 500 to 2,900m2. Aperture-dependent design was combined with fixed quotations for similar parts from the commercialized SkyTrough product, and established an installed cost of $130/m2 in 2020. This project was conducted in two phases. Phase I was a preliminary design, culminating in an optimum trough size and further improvement of an advanced polymeric reflective material. This phase was completed in October of 2011. Phase II has been the detailed engineering design and component testing, which culminated in the fabrication and testing of a single mirror module. Phase II is complete, and this document presents a summary of the comprehensive work.

  14. Radiation therapy for stage I and II testicular seminoma

    International Nuclear Information System (INIS)

    Latini, P.; Aristei, C.; Maranzano, E.; Checcaglini, F.; Panizza, M.B.; Perrucci, E.; Bellucci, M.C.

    1988-01-01

    From june 1977 through june 1987, 46 patients (36 evaluable) affected by stage I and II non-bulky testicular seminoma were treated with postoperative telecobaltotherapy (TCT). In stage I seminomas, radiotherapy was extended to the omolateral iliac and the para-aortic areas (total dose: 30 Gy over 4 weeks). In stage II seminomas, the subdiaphragmatic lymph nodes were irradiated with 40-45 Gy over 5-6 weeks; after an interval of one month the subdiaphragmatic lymph nodes were irradiated again with a total dose of 25 Gy over 3.5 weeks. Minimal follow-up lasted two years and maximum ten years (average:5.5%) recurrences occurred, but salvage radiotherapy and salvage chemotherapy respectively allowed a complete permanent remission. One patient died from a different neoplasia with no evidence of testicular involvement. The 5-year actuarial survival is 96.6±3.4. In 20% of the patients the side effects were nausea and/or vomiting, easily controlled. No late complications were observed

  15. Neuropsychiatric symptoms and quality of life in patients in the final phase of dementia.

    Science.gov (United States)

    Koopmans, Raymond T C M; van der Molen, Marloes; Raats, Monique; Ettema, Teake P

    2009-01-01

    To assess neuropsychiatric symptoms and quality of life in a group of patients in the final phase of dementia. All patients with dementia (n = 216) residing on dementia special care units of two Dutch nursing homes were included in the study provided they met the criteria for the final phase of dementia. Neuropsychiatric symptoms were assessed with the Neuropsychiatric Inventory Nursing Home version (NPI-NH) and the Cohen Mansfield Agitation Inventory (CMAI). Quality of life was assessed with the QUALIDEM. Of the 216 dementia patients 39 met the criteria for the final phase of dementia. The patients showed a specific pattern of behaviours with a high prevalence of apathy, agitation and behaviours that were mainly observed during morning care such as making strange noises, grabbing, performing repetitious mannerism, spitting, hitting, screaming and pushing. Overall quality of life of these patients in the final phase of dementia was moderate. In this small sample, patients in the final phase of dementia show specific behavioural problems, that mainly should be addressed with psychosocial interventions. (c) 2008 John Wiley & Sons, Ltd.

  16. Dynamics of process at the final stage of nuclear fission

    International Nuclear Information System (INIS)

    Koljari, I.G.; Mavlitov, N.D.

    2005-01-01

    Numerous experimental data show, that the final stage of nuclear fission near to a scission point plays an essential role at formation of characteristics of fission products. At the description of a final stage of fission there is a number of problems: Definition of the form of the nuclear near the scission point and definition forms of a fission fragments; The account of dynamic processes in compound nuclear directly before of fission. The condition of the quasistatic al adiabatic process - dS/dt=0 - is applied in a point of transition from the uniform compound nuclei to several forms for definition of generalized coordinates and speeds. Calculation of dependence of post neutrons from nuclear mass of fission fragments for reactions is α+ 83 Bi 209 → 85 At 213 (E lab = 45 MeV); α+ 92 U 242 → 94 Pu 242 (E lab = 45 MeV); 8 O 18 + 79 Au 197 → 97 Fr 215 (E lab = 159 MeV). System of equations, which describes behaviour of system in a point of nuclear fission-transition from the uniform form to system of a two (and, probably more) fission fragments is given. The system of the equations allows in a fission point to define the generalized coordinates, and the generalized speeds for each of the generalized coordinates of collective deformation variables

  17. Biomass gasification, stage 2 LTH. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bjerle, I.; Chambert, L.; Hallgren, A.; Hellgren, R.; Johansson, Anders; Mirazovic, M.; Maartensson, R.; Padban, N.; Ye Zhicheng [comps.] [Lund Univ. (Sweden). Dept. of Chemical Engineering II

    1996-11-01

    This report presents the final report of the first phase of a project dealing with a comprehensive investigation on pressurized biomass gasification. The intention with the project first phase was firstly to design, install and to take in operation a PCFB biomass gasifier. A thorough feasibility study was made during the first half year including extensive calculations on an internal circulating fluidized bed concept. The experimental phase was intended to study pressurized gasification up to 2.5 MPa (N{sub 2}, air) at temperatures in the interval 850-950 deg C. The more specific experimental objective was to examine the impact from various process conditions on the product formation as well as on the function of the different systems. The technical concept has been able to offer novel approaches regarding biomass feeding and PCFB gasification. The first gasification test run was made in December 1993 after almost 18 months of installation work. Extensive work was made during 1994 and the first half of 1995 to find the balance of the PCFB gasifier. It turned out to be very difficult to find operating parameters such that gave a stable circulation of the bed material during gasification mode. Apparently, the produced gas partly changed the pressure profile over the riser which in turn gave unstable operation. After a comprehensive investigation involving more than 100 hours of tests runs it was decided to leave the circulating bed concept and focus on bubbling bed operations. The test rig is currently operating as a bubbling bed gasifier. 4 refs, 24 figs, 6 tabs

  18. Radiotherapy for stage I-II non-small cell lung cancer

    International Nuclear Information System (INIS)

    Okamoto, Yoshiaki; Murakami, Masao; Mizowaki, Takashi; Nakajima, Toshifumi; Kuroda, Yasumasa

    1999-01-01

    Surgery has been regarded as the standard treatment for patients with non-small cell lung cancer in the early stage, while radiotherapy has become an effective alternative for medically inoperable patients and those who refuse surgery. We reviewed the records of 31 patients with stage I-II non-small cell lung cancer treated by radiotherapy between 1980 and 1997. There were 15 patients in stage I and 16 in stage II. The variables analyzed for influence on cause-specific survival and loco-regional control were: age, performance status, clinical stage, tumor size, tumor site, radiation field, radiation dose, and combination with chemotherapy. The overall and cause-specific 1-, 2-, 3-, and 5-years survival rates were 71% and 77%; 63% and 73%; 34% and 48%; and 17% and 32%, respectively. Five-year survival rate for patients with peripheral tumor in the lung was 72%, with 70% loco-regional control, while the 5-year survival rate of patients whose tumor originated in the central region was 20%, with 25% loco-regional control. These differences had marginal significance on univariate analysis (P=0.07), but only tumor site (central vs peripheral) showed marginal significant influence on cause-specific survival (P=0.08) and loco-regional control (P=0.07) on multivariate analysis. There were no fatal complications, including radiation-induced myelopathy. The present series showed satisfactory results with definitive radiotherapy for patients with medically inoperable stage I-II non-small cell lung cancer, with results similar to those in recent reports of radiotherapy. The only significant variable was that patients with peripheral tumors had a better prognosis than patients with central tumors. (author)

  19. Organic Rankine Kilowatt Isotope Power System. Final phase I report

    International Nuclear Information System (INIS)

    1978-01-01

    On 1 August 1975 under Department of Energy Contract EN-77-C-02-4299, Sundstrand Energy Systems commenced development of a Kilowatt Isotope Power System (KIPS) directed toward satisfying the higher power requirements of satellites of the 1980s and beyond. The KIPS is a 238 PuO 2 fueled organic Rankine cycle turbine power system which will provide design output power in the range of 500 to 2000 W/sub (e)/ with a minimum of system changes. The principal objectives of the Phase 1 development effort were to: conceptually design a flight system; design a Ground Demonstration System (GDS) that is prototypic of the flight system in order to prove the feasibility of the flight system design; fabricate and assemble the GDS; and performance and endurance test the GDS using electric heaters in lieu of the isotope heat source. Results of the work performed under the Phase 1 contract to 1 July 1978 are presented

  20. Research program in reactor core diagnostics with neutron noise methods: Stage 3. Final report

    International Nuclear Information System (INIS)

    Pazsit, I.; Garis, N.S.; Karlsson, J.; Racz, A.

    1997-09-01

    Stage 3 of the program has been executed 96-04-12. The long term goal is to develop noise methods for identification and localization of perturbations in reactor cores. The main parts of the program consist of modelling the noise source, calculation of the space- and frequency dependent transfer function, calculation of the neutron noise via a convolution of the transfer function of the system and the noise source, i.e. the perturbation, and finally finding an inversion or unfolding procedure to determine noise source parameters from the neutron noise. Most previous work is based on very simple (analytical) reactor models for the calculation of the transfer function as well as analytical unfolding methods. The purpose of this project is to calculate the transfer function in a more realistic model as well as elaborating powerful inversion methods that do not require analytical transfer functions. The work in stage 3 is described under the following headlines: Further investigation of simplified models for the calculation of the neutron noise; Further investigation of methods based on neural networks; Further investigation of methods for detecting the vibrations and impacting of detectors; Application of static codes for determination of the neutron noise using the adiabatic approximation

  1. A predictive mathematical model for the calculation of the final mass of Graves' disease thyroids treated with 131I

    Science.gov (United States)

    Traino, Antonio C.; Di Martino, Fabio; Grosso, Mariano; Monzani, Fabio; Dardano, Angela; Caraccio, Nadia; Mariani, Giuliano; Lazzeri, Mauro

    2005-05-01

    Substantial reductions in thyroid volume (up to 70-80%) after radioiodine therapy of Graves' hyperthyroidism are common and have been reported in the literature. A relationship between thyroid volume reduction and outcome of 131I therapy of Graves' disease has been reported by some authors. This important result could be used to decide individually the optimal radioiodine activity A0 (MBq) to administer to the patient, but a predictive model relating the change in gland volume to A0 is required. Recently, a mathematical model of thyroid mass reduction during the clearance phase (30-35 days) after 131I administration to patients with Graves' disease has been published and used as the basis for prescribing the therapeutic thyroid absorbed dose. It is well known that the thyroid volume reduction goes on until 1 year after therapy. In this paper, a mathematical model to predict the final mass of Graves' diseased thyroids submitted to 131I therapy is presented. This model represents a tentative explanation of what occurs macroscopically after the end of the clearance phase of radioiodine in the gland (the so-called second-order effects). It is shown that the final thyroid mass depends on its basal mass, on the radiation dose absorbed by the gland and on a constant value α typical of thyroid tissue. α has been evaluated based on a set of measurements made in 15 reference patients affected by Graves' disease and submitted to 131I therapy. A predictive equation for the calculation of the final mass of thyroid is presented. It is based on macroscopic parameters measurable after a diagnostic 131I capsule administration (0.37-1.85 MBq), before giving the therapy. The final mass calculated using this equation is compared to the final mass of thyroid measured 1 year after therapy administration in 22 Graves' diseased patients. The final masses calculated and measured 1 year after therapy are in fairly good agreement (R = 0.81). The possibility, for the physician, to decide a

  2. A predictive mathematical model for the calculation of the final mass of Graves' disease thyroids treated with 131I

    International Nuclear Information System (INIS)

    Traino, Antonio C; Martino, Fabio Di; Grosso, Mariano; Monzani, Fabio; Dardano, Angela; Caraccio, Nadia; Mariani, Giuliano; Lazzeri, Mauro

    2005-01-01

    Substantial reductions in thyroid volume (up to 70-80%) after radioiodine therapy of Graves' hyperthyroidism are common and have been reported in the literature. A relationship between thyroid volume reduction and outcome of 131 I therapy of Graves' disease has been reported by some authors. This important result could be used to decide individually the optimal radioiodine activity A 0 (MBq) to administer to the patient, but a predictive model relating the change in gland volume to A 0 is required. Recently, a mathematical model of thyroid mass reduction during the clearance phase (30-35 days) after 131 I administration to patients with Graves' disease has been published and used as the basis for prescribing the therapeutic thyroid absorbed dose. It is well known that the thyroid volume reduction goes on until 1 year after therapy. In this paper, a mathematical model to predict the final mass of Graves' diseased thyroids submitted to 131 I therapy is presented. This model represents a tentative explanation of what occurs macroscopically after the end of the clearance phase of radioiodine in the gland (the so-called second-order effects). It is shown that the final thyroid mass depends on its basal mass, on the radiation dose absorbed by the gland and on a constant value α typical of thyroid tissue. α has been evaluated based on a set of measurements made in 15 reference patients affected by Graves' disease and submitted to 131 I therapy. A predictive equation for the calculation of the final mass of thyroid is presented. It is based on macroscopic parameters measurable after a diagnostic 131 I capsule administration (0.37-1.85 MBq), before giving the therapy. The final mass calculated using this equation is compared to the final mass of thyroid measured 1 year after therapy administration in 22 Graves' diseased patients. The final masses calculated and measured 1 year after therapy are in fairly good agreement (R = 0.81). The possibility, for the physician, to

  3. Savanna ecosystem project: phase I summary and phase II progress

    CSIR Research Space (South Africa)

    Huntely, BJ

    1978-07-01

    Full Text Available A summary of the results of the first phase (mid 1974 to mid 1976) of the South African Savanna Ecosystem Project being undertaken at Nylsvley in the northern Transvaal is presented. Phase I of this ten year study of the structure and functioning...

  4. Magnetic liquid metal two-phase flow research. Phase 1. Final report

    International Nuclear Information System (INIS)

    Graves, R.D.

    1983-04-01

    The Phase I research demonstrates the feasibility of the magnetic liquid metal (MLM) two-phase flow concept. A dispersion analysis is presented based on a complete set of two-phase-flow equations augmented to include stresses due to magnetic polarization of the fluid. The analysis shows that the stability of the MLM two-phase flow is determined by the magnetic Mach number, the slip ratio, geometry of the flow relative to the applied magnetic field, and by the voidage dependence of the interfacial forces. Results of a set of experiments concerned with magnetic effects on the dynamics of single bubble motion in an aqueous-based, viscous, conducting magnetic fluid are presented. Predictions in the theoretical literature are qualitatively verified using a bench-top experimental apparatus. In particular, applied magnetic fields are seen to lead to reduced bubble size at fixed generating orifice pressure

  5. Automated baseline change detection phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The Automated Baseline Change Detection (ABCD) project is supported by the DOE Morgantown Energy Technology Center (METC) as part of its ER&WM cross-cutting technology program in robotics. Phase 1 of the Automated Baseline Change Detection project is summarized in this topical report. The primary objective of this project is to apply robotic and optical sensor technology to the operational inspection of mixed toxic and radioactive waste stored in barrels, using Automated Baseline Change Detection (ABCD), based on image subtraction. Absolute change detection is based on detecting any visible physical changes, regardless of cause, between a current inspection image of a barrel and an archived baseline image of the same barrel. Thus, in addition to rust, the ABCD system can also detect corrosion, leaks, dents, and bulges. The ABCD approach and method rely on precise camera positioning and repositioning relative to the barrel and on feature recognition in images. In support of this primary objective, there are secondary objectives to determine DOE operational inspection requirements and DOE system fielding requirements.

  6. Automated baseline change detection phase I. Final report

    International Nuclear Information System (INIS)

    1995-12-01

    The Automated Baseline Change Detection (ABCD) project is supported by the DOE Morgantown Energy Technology Center (METC) as part of its ER ampersand WM cross-cutting technology program in robotics. Phase 1 of the Automated Baseline Change Detection project is summarized in this topical report. The primary objective of this project is to apply robotic and optical sensor technology to the operational inspection of mixed toxic and radioactive waste stored in barrels, using Automated Baseline Change Detection (ABCD), based on image subtraction. Absolute change detection is based on detecting any visible physical changes, regardless of cause, between a current inspection image of a barrel and an archived baseline image of the same barrel. Thus, in addition to rust, the ABCD system can also detect corrosion, leaks, dents, and bulges. The ABCD approach and method rely on precise camera positioning and repositioning relative to the barrel and on feature recognition in images. In support of this primary objective, there are secondary objectives to determine DOE operational inspection requirements and DOE system fielding requirements

  7. Nano-scale clusters formed in the early stage of phase decomposition of Al-Mg-Si alloys

    Energy Technology Data Exchange (ETDEWEB)

    Hirosawa, S.; Sato, T. [Dept. of Metallurgy and Ceramics Science, Tokyo Inst. of Tech. (Japan)

    2005-07-01

    The formation of nano-scale clusters (nanoclusters) prior to the precipitation of the strengthening {beta}'' phase significantly influences two-step aging behavior of Al-Mg-Si alloys. In this work, the existence of two kinds of nanoclusters has been verified in the early stage of phase decomposition by differential scanning calorimetry (DSC) and three-dimensional atom probe (3DAP). Pre-aging treatment at 373 K before natural aging was also found to form preferentially one of the two nanoclusters, resulting in the remarkable restoration of age-hardenability at paint-bake temperatures. Such microstructural control by means of optimized heat-treatments; i.e. nanocluster assist processing (NCAP), possesses great potential for enabling Al-Mg-Si alloys to be used more widely as a body-sheet material of automobiles. (orig.)

  8. Disposal of chemical agents and munitions stored at Pueblo Depot Activity, Colorado. Final, Phase 1: Environmental report

    Energy Technology Data Exchange (ETDEWEB)

    Terry, J.W.; Blasing, T.J.; Ensminger, J.T.; Johnson, R.O.; Schexnayder, S.M.; Shor, J.T.; Staub, W.P.; Tolbert, V.R.; Zimmerman, G.P.

    1995-04-01

    Under the Chemical Stockpile Disposal Program (CSDP), the US Army proposes to dispose of lethal chemical agents and munitions stored at eight existing Army installations in the continental United States. In 1988, the US Army issued the final programmatic environmental impact statement (FPEIS) for the CSDP. The FPEIS and the subsequent Record of Decision (ROD) identified an on-site disposal process as the preferred method for destruction of the stockpile. That is, the FPEIS determined the environmentally preferred alternative to be on-site disposal in high-temperature incinerators, while the ROD selected this alternative for implementation as the preferred method for destruction of the stockpile. In this Phase I report, the overall CSDP decision regarding disposal of the PUDA Stockpile is subjected to further analyses, and its validity at PUDA is reviewed with newer, more detailed data than those providing the basis for the conclusions in the FPEIS. The findings of this Phase I report will be factored into the scope of a site-specific environmental impact statement to be prepared for the destruction of the PUDA stockpile. The focus of this Phase I report is on those data identified as having the potential to alter the Army`s previous decision regarding disposal of the PUDA stockpile; however, several other factors beyond the scope of this Phase I report must also be acknowledged to have the potential to change or modify the Army`s decisions regarding PUDA.

  9. Hybrid Nanocomposite Photovoltaics, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will develop an innovative solar cell design that combines nanotechnology with conducting polymer...

  10. Final Stage Development of Reactor Console Simulator

    International Nuclear Information System (INIS)

    Mohamad Idris Taib; Ridzuan Abdul Mutalib; Zareen Khan Abdul Jalil Khan; Mohd Khairulezwan Abdul Manan; Mohd Sabri Minhat; Nurfarhana Ayuni Joha

    2013-01-01

    The Reactor Console Simulator PUSPATI TRIGA Reactor was developed since end of 2011 and now in the final stage of development. It is will be an interactive tool for operator training and teaching of PUSPATI TRIGA Reactor. Behavior and characteristic for reactor console and reactor itself can be evaluated and understand. This Simulator will be used as complement for actual present reactor console. Implementation of human system interface (HSI) is using computer screens, keyboard and mouse. Multiple screens are used to match the physical of present reactor console. LabVIEW software are using for user interface and mathematical calculation. Polynomial equation based on control rods calibration data as well as operation parameters record was used to calculate and estimated reactor console parameters. The capabilities in user interface, reactor physics and thermal-hydraulics can be expanded and explored to simulation as well as modeling for New Reactor Console, Research Reactor and Nuclear Power Plant. (author)

  11. ALMIP Phase I Report

    DEFF Research Database (Denmark)

    Boone, Aaron; de Rosnay, Patricia; Beljaars, Anton

      This report describes the experimental setup and results of the Phase 1 (i.e. the Regional Scale) of the AMMA (African Monsoon Multidisciplinary Analysis) Land surface Model Intercomparison Project (ALMIP). It is part of the AMMA-EU (European Union) and API  (Action Programmée Interorganisme...

  12. Automated recognition of helium speech. Phase I: Investigation of microprocessor based analysis/synthesis system

    Science.gov (United States)

    Jelinek, H. J.

    1986-01-01

    This is the Final Report of Electronic Design Associates on its Phase I SBIR project. The purpose of this project is to develop a method for correcting helium speech, as experienced in diver-surface communication. The goal of the Phase I study was to design, prototype, and evaluate a real time helium speech corrector system based upon digital signal processing techniques. The general approach was to develop hardware (an IBM PC board) to digitize helium speech and software (a LAMBDA computer based simulation) to translate the speech. As planned in the study proposal, this initial prototype may now be used to assess expected performance from a self contained real time system which uses an identical algorithm. The Final Report details the work carried out to produce the prototype system. Four major project tasks were: a signal processing scheme for converting helium speech to normal sounding speech was generated. The signal processing scheme was simulated on a general purpose (LAMDA) computer. Actual helium speech was supplied to the simulation and the converted speech was generated. An IBM-PC based 14 bit data Input/Output board was designed and built. A bibliography of references on speech processing was generated.

  13. Systems study of fuels from grains and grasses. Phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Benson, W.; Allen, A.; Athey, R.; McElroy, A.; Davis, M.; Bennett, M.

    1978-02-24

    The program reported on herein consists of a first phase analysis of the potential for significant and economically viable contributions to U.S. energy needs from grasses and grains by the photosynthetic production of biomass. The study does not include other cultivated crops such as sugar cane, sugar beets, cotton, tobacco, vegetables, fruits, etc. The scope of the study encompasses grain crop residues, whole plant biomass from grain crops and nongrain crops on cropland, and whole plant biomass from grasses on pasture, rangeland, and federal range. The basic approach to the study involves first an assessment of current total biomass generation from the various grasses and grains on cropland, pasture, range, and federal range, and aggregating the production by combinations of crop residues and whole plant biomass; second, evaluation of possibilities for introduction of new crops and expanding production to marginal or presently idle land; third, development of proposed reasonable scenarios for actually harvesting biomass from selected combinations of crop residues, forages and hays, and new crops from land now in production, plus additional marginal or underutilized land brought into production; and finally, assessment on national and regional or local scales of the production that might be affected by reasonable scenarios. This latter effort includes analysis of tentative possibilities for reallocating priorities and needs with regard to production of grain for export or for livestock production. The overall program includes a case study analysis of production economics for a representative farm of about 1,000 acres (405 ha) located in Iowa.

  14. Size-Controlled AgI/Ag Heteronanowires in Highly Ordered Alumina Membranes: Superionic Phase Stabilization and Conductivity.

    Science.gov (United States)

    Zhang, Hemin; Tsuchiya, Takashi; Liang, Changhao; Terabe, Kazuya

    2015-08-12

    Nanoscaled ionic conductors are crucial for future nanodevices. A well-known ionic conductor, AgI, exhibited conductivity greater than 1 Ω(-1) cm(-1) in α-phase and transformed into poorly conducting β-/γ-phase below 147 °C, thereby limiting applications. Here, we report that transition temperatures both from the β-/γ- to α-phase (Tc↑) and the α- to β-/γ-phase (Tc↓) are tuned by AgI/Ag heteronanowires embedded in anodic aluminum oxide (AAO) membranes with 10-30 nm pores. Tc↑ and Tc↓ shift to correspondingly higher and lower temperature as pore size decreases, generating a progressively enlarged thermal hysteresis. Tc↑ and Tc↓ specifically achieve 185 and 52 °C in 10 nm pores, and the final survived conductivity reaches ∼8.3 × 10(-3) Ω(-1) cm(-1) at room temperature. Moreover, the low-temperature stabilizing α-phase (down to 21 °C, the lowest in state of the art temperatures) is reproducible and survives further thermal cycling. The low-temperature phase stabilization and enhancement conductivity reported here suggest promising applications in silver-ion-based future nanodevices.

  15. A New Concept of Two-Stage Multi-Element Resonant-/Cyclo-Converter for Two-Phase IM/SM Motor

    Directory of Open Access Journals (Sweden)

    Mahmud Ali Rzig Abdalmula

    2013-01-01

    Full Text Available The paper deals with a new concept of power electronic two-phase system with two-stage DC/AC/AC converter and two-phase IM/PMSM motor. The proposed system consisting of two-stage converter comprises: input resonant boost converter with AC output, two-phase half-bridge cyclo-converter commutated by HF AC input voltage, and induction or synchronous motor. Such a system with AC interlink, as a whole unit, has better properties as a 3-phase reference VSI inverter: higher efficiency due to soft switching of both converter stages, higher switching frequency, smaller dimensions and weight with lesser number of power semiconductor switches and better price. In comparison with currently used conventional system configurations the proposed system features a good efficiency of electronic converters and also has a good torque overloading of two-phase AC induction or synchronous motors. Design of two-stage multi-element resonant converter and results of simulation experiments are presented in the paper.

  16. Dose Escalation Methods in Phase I Cancer Clinical Trials

    OpenAIRE

    Le Tourneau, Christophe; Lee, J. Jack; Siu, Lillian L.

    2009-01-01

    Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid exposing too many patients to subtherapeutic doses while preserving safety and maintaining rapid accrual. Here we review dose escalation methods for phase I trials, including the rule-based and model-...

  17. Lymphography and computed tomography of abdominal nodes in newly diagnosed patients with Hodgkin's disease in clinical stage I-III

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, C.H.

    1986-10-01

    Between 1978 and 1983, 80 patients with Hodgkin's disease (HD) in clinical Stage I-III had computed tomography (CT) of the abdomen and pelvis and lymphography (LAG) prior to staging laparatomy with multiple lymph node biopsies at Stanford University Medical Center. There were 224 biopsied nodal sites. The sensitivity and specificity for CT to determine the status of biopsied paraortic and iliac nodes was .61 and .91 vs. .94 and .90 for LAG. CT appeared of even lower sensitivity (.13) in evaluating splenic hilar, celiac axis and portal nodes. Including all biopsy proven subdiaphragmatic nodal sites, CT's sensitivity to diagnose the presence of subdiaphragmatic adenopathy was .38 vs. .52 in LAG. Assessment of the final pathological stage was more successful by LAG (.61) than by CT (.49). Positive and negative predictive values of both tests indicate higher reliability of LAG results as regards individual intraabdominal nodes (LAG .71, .98 vs. CT .58, .86), the entire subdiaphragmatic nodal area (LAG .79, .77 vs. CT .61, .71) and prediction of final pathological stage. LAG appeared to be the more useful test during initial staging of newly diagnosed and untreated patients with HD. None of the test for itself or in combination can replace laparatomy when exact information is necessary for further clinical decisions.

  18. A Canadian recycling newsletter. Final phase

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    A study was performed to publish a Canadian recycling newsletter, to be distributed gradually throughout the country. This report reviews the format, data collection procedures, printing, mailing, advertising, marketing, promotion, and finances of the publication. In the final phase of the study, publication and distribution was to extend to various segments of the secondary materials industry. This would include publishing articles and industry briefs related to the ferrous and non-ferrous metals industry. The publication would be increased to 12 pages and would attempt to become financially self-sufficient. In this phase, the newsletter became firmly established as the voice of Canada's secondary materials market, especially waste paper, where the price guide published by the newsletter became a sort of recognized standard. It was found that financially independent operation was achieved within one year. The newsletter was published on schedule and reader response was positive. Examples of the newsletter, called Recoup, are included in the appendix.

  19. Risk Assessment Challenges in the Ares I Upper Stage

    Science.gov (United States)

    Stott, James E.; Ring, Robert W.; Elrada, Hassan A.; Hark, Frank

    2007-01-01

    NASA Marshall Space Flight Center (MSFC) is currently at work developing hardware and systems for the Ares I rocket that will send future astronauts into orbit. Built on cutting-edge launch technologies, evolved powerful Apollo and Space Shuttle propulsion elements, and decades of NASA spaceflight experience, Ares I is the essential core of a safe, reliable, cost-effective space transportation system -- one that will carry crewed missions back to the moon, on to Mars and out into the solar system. Ares I is an in-line, two-stage rocket configuration topped by the Orion crew vehicle and its launch abort system. In addition to the vehicle's primary mission -carrying crews of four to six astronauts to Earth orbit --Ares I may also use its 25-ton payload capacity to deliver resources and supplies to the International Space Station, or to "park" payloads in orbit for retrieval by other spacecraft bound for the moon or other destinations. Crew transportation to the International Space Station is planned to begin no later than 2014. The first lunar excursion is scheduled for the 2020 timeframe. This paper presents the challenges in designing the Ares I upper stage for reliability and safety while minimizing weight and maximizing performance.

  20. High-pressure phases of CuI studied by 129I-Moessbauer spectroscopy

    International Nuclear Information System (INIS)

    Kaindl, G.; Nowik, I.; Frank, K.H.

    1992-01-01

    The results of an 129 I-Moessbauer study of the high-pressure phases of CuI at 4.2 K and for external pressures up to 71 kbar are reported. The isomer shift S and the electric quadrupole interaction E q are found to undergo large discontinuities at the crystallographic phase-transition pressures of ≅18 kbar from zinc-blende to rhombohedral structure and at ≅46 kbar from rhombohedral to tetragonal. The pressure coefficients of these hyperfine parameters are significantly different for the three phases (zinc-blende; rhombohedral; tetragonal): dS/dP=-3.3; =+1.5; =+2.5x10 -3 mm/s/kbar. These results cannot be explained in terms of a simple molecular-orbital picture; instead, they reflect pressure-induced variations of the halogen-p/metal-d hybridization in the valence bands of the various phases of CuI. (orig.)

  1. Control of Single-Stage Single-Phase PV inverter

    DEFF Research Database (Denmark)

    Ciobotaru, Mihai; Teodorescu, Remus; Blaabjerg, Frede

    2005-01-01

    In this paper the issue of control strategies for single-stage photovoltaic (PV) inverter is addressed. Two different current controllers have been implemented and an experimental comparison between them has been made. A complete control structure for the single-phase PV system is also presented......-forward; - and the grid current controller implemented in two different ways, using the classical proportional integral (PI) and the novel proportional resonant (PR) controllers. The control strategy was tested experimentally on 1.5 kW PV inverter....

  2. SmartPark Technology Demonstration Project, Phase II: Final Report

    Science.gov (United States)

    2018-05-01

    The purpose of FMCSA's SmartPark project was to determine the feasibility of a technology for providing truck parking space availability information in real time to truckers on the road. SmartPark consisted of two phases. Phase I was a field operatio...

  3. Benchmarks for Uncertainty Analysis in Modelling (UAM) for the Design, Operation and Safety Analysis of LWRs - Volume I: Specification and Support Data for Neutronics Cases (Phase I)

    International Nuclear Information System (INIS)

    Ivanov, K.; Avramova, M.; Kamerow, S.; Kodeli, I.; Sartori, E.; Ivanov, E.; Cabellos, O.

    2013-01-01

    role. The participants are responsible for performing convergence studies with their computer codes in order to remove the uncertainties associated with numerical approximations (numerical method uncertainties) and reduce the uncertainties associated with the methods (physics uncertainties) used in their codes. The method related contribution of uncertainty can be derived from earlier benchmarks conducted within NEA/OECD or from the verification (mathematics) and validation (physics) studies performed with the computer code of choice. In the current LWR standard calculation scheme (utilised in industry and regulation) different modelling approximations are usually used at different stages of the calculation. These approximations are the second important source of input uncertainty. In order to assess the uncertainties due to utilisation of the above-mentioned approximations, one has to decompose and evaluate the errors of these approximations. Evaluation of the uncertainties introduced with such modelling approximations is important because in some situations these approximations work well and in others they do not. This is accomplished by designing appropriate test problems for a given exercise. Geometry, material properties and manufacturing uncertainties are also an important source of calculation uncertainty. Information for these uncertainties for the different test models as well as on their propagation will be provided in the final report on Phase I by the benchmark team. Understanding the uncertainties in key output reactor core parameters associated with steady-state core simulation is important with regard to introducing appropriate design margins and deciding where efforts should be directed to reduce uncertainties. The obtained output uncertainties from Phase I of the OECD LWR UAM benchmark will be utilised as input uncertainties in the remaining two phases - Phase II (Core Phase) and Phase III (System Phase)

  4. Catalyst dispersion and activity under conditions of temperature-staged liquefaction. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Davis, A.; Schobert, H.H.; Mitchell, G.D.; Artok, L.

    1993-02-01

    This research program involves the investigation of the use of highly dispersed catalyst precursors for the pretreatment of coals by mild hydrogenation. During the course of this effort solvent preswelling of the coal was evaluated as a means of deeply impregnating catalysts into coal, active phases of catalysts under reaction conditions were studied and the impact of these techniques were evaluated during pretreatment and temperature-staged liquefaction. Two coals, a Texas subbituminous and a Utah high volatile A bituminous, were used to examine the effects of solvent swelling pretreatment and catalyst impregnation on conversion behavior at 275{degrees}C, representative of the first, low-temperature stage in a temperature-staged liquefaction reaction. Ferrous sulfate, iron pentacarbonyl, ammonium tetrathiomolybdate, and molybdenum hexacarbonyl were used as catalyst precursors. Without swelling pretreatment, impregnation of both coals increased conversion, mainly through increased yields of preasphaltenes.

  5. Postoperative radiotherapy for stage I/II seminoma: results for 212 patients

    International Nuclear Information System (INIS)

    Bauman, Glenn S.; Venkatesan, Varagur M.; Ago, C. Tetteh; Radwan, John S.; Dar, A. Rashid; Winquist, Eric W.

    1998-01-01

    Purpose: A retrospective review of patients with Stage I and II seminoma treated at a regional cancer center was performed to assess the long term efficacy and toxicity associated with post operative radiotherapy. Methods and Materials: Between 1950 and 1995, 212 patients seen at the London Regional Cancer Centre received adjuvant radiotherapy following orchiectomy for Stage I (169) and II (43) seminoma. Median follow-up for the group was 7.5 years. Results: Progression free, cause specific, and overall survival were 95%, 98%, and 95% at 5 years, and 94%, 98%, and 94% at 10 years respectively. An increased risk of failure was noted among patients with bulky Stage II disease. No other prognostic factors for relapse were identified. Late toxicity was uncommon with only 12/212 (6%) developing any late GI toxicity potentially attributable to radiotherapy. The incidence of second malignancies (excluding second testicular tumors) was 6/212 (actuarial:1%, 1%, 6% at 5,10,15 years respectively). There was a trend toward increased acute complications for patients treated with larger volumes of radiation. No prognostic factors associated with increased risk of late toxicity or second malignancy were identified, likely a consequence of the small number of these events. Conclusion: Survival and toxicity were comparable to that reported in the literature. Post-operative radiotherapy remains a safe and efficacious adjuvant treatment for Stage I and early Stage II seminoma

  6. Single high dose intraoperative electrons for advanced stage pancreatic cancer: Phase I pilot study

    International Nuclear Information System (INIS)

    Goldson, A.L.; Ashaveri, E.; Espinoza, M.C.

    1981-01-01

    Phase I toxicity studies with intraoperative radiotherapy proved to be a feasible adjunct to surgery for unresectable malignancies of the pancreas at Howard University Hospital. There have been minimal side effects or complications related to the combination of limited surgical decompression and intraoperative radiotherapy alone. The toxic effects of intraoperative radiotherapy on normal tissues is being assessed on a dose volume basis. Doses of 2000 to 2500 rad in a single exposure to include the pancreas, regional nodes and duodenum are acceptable if the total treatment volume is less than or equal to 100 cm. The tumoricidal effects on the cancer are demonstratable when one reviews the pathological specimens that illustrate massive tumor necrosis and fibros replacement, but in all cases reviewed, viable cancer was noted. Intraoperative radiotherapy, therefore, represents a significant boost dose for resectable, partially resectable or non-resectable tumors when added to conventional external beam irradiation and/or chemotherapy. Preliminary clinical data and minimal toxicity justifies further investigation

  7. Evaluation and silicon nitride internal combustion engine components. Final report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Voldrich, W. [Allied-Signal Aerospace Co., Torrance, CA (United States). Garrett Ceramic Components Div.

    1992-04-01

    The feasibility of silicon nitride (Si{sub 3}N{sub 4}) use in internal combustion engines was studied by testing three different components for wear resistance and lower reciprocating mass. The information obtained from these preliminary spin rig and engine tests indicates several design changes are necessary to survive high-stress engine applications. The three silicon nitride components tested were valve spring retainers, tappet rollers, and fuel pump push rod ends. Garrett Ceramic Components` gas-pressure sinterable Si{sub 3}N{sub 4} (GS-44) was used to fabricate the above components. Components were final machined from densified blanks that had been green formed by isostatic pressing of GS-44 granules. Spin rig testing of the valve spring retainers indicated that these Si{sub 3}N{sub 4} components could survive at high RPM levels (9,500) when teamed with silicon nitride valves and lower spring tension than standard titanium components. Silicon nitride tappet rollers showed no wear on roller O.D. or I.D. surfaces, steel axles and lifters; however, due to the uncrowned design of these particular rollers the cam lobes indicated wear after spin rig testing. Fuel pump push rod ends were successful at reducing wear on the cam lobe and rod end when tested on spin rigs and in real-world race applications.

  8. Composite Repair System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — GTL has developed an innovative composite repair methodology known as the Composite Repair System (CRS). In this phase I effort, CRS is being developed for the...

  9. 40 CFR 73.25 - Phase I extension reserve.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Phase I extension reserve. 73.25 Section 73.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.25 Phase I extension reserve. The...

  10. Generating a robust prediction model for stage I lung adenocarcinoma recurrence after surgical resection.

    Science.gov (United States)

    Wu, Yu-Chung; Wei, Nien-Chih; Hung, Jung-Jyh; Yeh, Yi-Chen; Su, Li-Jen; Hsu, Wen-Hu; Chou, Teh-Ying

    2017-10-03

    Lung cancer mortality remains high even after successful resection. Adjuvant treatment benefits stage II and III patients, but not stage I patients, and most studies fail to predict recurrence in stage I patients. Our study included 211 lung adenocarcinoma patients (stages I-IIIA; 81% stage I) who received curative resections at Taipei Veterans General Hospital between January 2001 and December 2012. We generated a prediction model using 153 samples, with validation using an additional 58 clinical outcome-blinded samples. Gene expression profiles were generated using formalin-fixed, paraffin-embedded tissue samples and microarrays. Data analysis was performed using a supervised clustering method. The prediction model generated from mixed stage samples successfully separated patients at high vs. low risk for recurrence. The validation tests hazard ratio (HR = 4.38) was similar to that of the training tests (HR = 4.53), indicating a robust training process. Our prediction model successfully distinguished high- from low-risk stage IA and IB patients, with a difference in 5-year disease-free survival between high- and low-risk patients of 42% for stage IA and 45% for stage IB ( p model for identifying lung adenocarcinoma patients at high risk for recurrence who may benefit from adjuvant therapy. Our prediction performance of the difference in disease free survival between high risk and low risk groups demonstrates more than two fold improvement over earlier published results.

  11. Investigation and thermodynamic calculation of phase diagram of CdI2-PbI2-NaI system

    International Nuclear Information System (INIS)

    Storonkin, A.V.; Vasil'kova, I.V.; Korobkov, S.V.

    1976-01-01

    Using the thermographic and X-ray phase analyses binary CdI 2 -PbI 2 , PI 2 -NaI, CdI 2 -NaI systems and a triple CdI 2 -PbI 2 -NaI system are investigated and their melting diagrams are plotted. A method of thermodynamic calculation has been proposed and tested of the shape of the eutectic lines for the system CdI 2 -PbI 2 -NaI, taking into account the non-ideality of the liquid phase. The method uses data obtained for the binary systems. The liquidus surface of the triple system has been constructed on the basis of the calculation. The results of the calculation of the triple eutectics are in good agreement with the experimental data

  12. Evaluation of the I. Stage of decommissioning and implementation of the II. Stage of decommissioning of NPP V1

    International Nuclear Information System (INIS)

    Hrasnova, E.

    2015-01-01

    In this paper author deals with following aspects: 1. Introduction of company Nuclear and Decommissioning Company, plc; 2. Evaluation of the I. stage of decommissioning and implementation of the II. Stage of decommissioning of NPP V1; (author)

  13. C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 2: Test Bed Performance Evaluation and Final AeroMACS Recommendations

    Science.gov (United States)

    Hall, Edward; Magner, James

    2011-01-01

    This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II (this document) describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

  14. APT, The Phase I tool for HST Cycle 12

    Science.gov (United States)

    Blacker, Brett S.; Bertch, Maria; Curtis, Gary; Douglas, Robert E., Jr.; Krueger, Anthony P.

    2002-12-01

    In the continuing effort to streamline our systems and improve service to the science community, the Space Telescope Science Institute (STScI) is developing and releasing, APT The Astronomer’s Proposal Tool as the new interface for Hubble Space Telescope (HST) Phase I and Phase II proposal submissions for HST Cycle 12. APT, was formerly called the Scientist’s Expert Assistant (SEA), which started as a prototype effort to try and bring state of the art technology, more visual tools and power into the hands of proposers so that they can optimize the scientific return of their programs as well as HST. Proposing for HST and other missions, consists of requesting observing time and/or archival research funding. This step is called Phase I, where the scientific merit of a proposal is considered by a community based peer-review process. Accepted proposals then proceed thru Phase II, where the observations are specified in sufficient detail to enable scheduling on the telescope. In this paper, we will present our concept and implementation plans for our Phase I development and submission tool, APT. More importantly, we will go behind the scenes and discuss why it’s important for the Science Policies Division (SPD) and other groups at the STScI to have a new submission tool and submission output products. This paper is an update of the status of the HST Phase I Proposal Processing System that was described in the published paper “A New Era for HST Phase I Development and Submission.”

  15. Result of Radiation Therapy for Stage I, II Non-Hodgkin Lymphoma

    International Nuclear Information System (INIS)

    Lee, Kyu Chan; Kim, Chul Yong; Choi, Myung Sun

    1993-01-01

    A retrospective analysis was done for 69 patients with Stage I and II non-Hodgkin lymphoma who were treated from May 1981 to December 1990, in the Department of Radiadtion Oncology, Korea University Hospital. We used Ann Arbor Staging system and Working Formulation for histological classification. Forty-three patients(43/69, 62.3%) were Stage I and 26 patients (26/69, 37.7%) were Stage II, and B symptom was found in 10.1%(7/69). Local control rate for all patients was 88.4%(61/69), with 80% (12/15) for nodal lymphoma and 90.7%(49/54) for extra nodal lymphoma. The total failure rate was 34.8%(24/69). Five of 24 (20.8%) patients who were failed developed local failure only, 12.5%(3/24) local failure with distant failure, and distant failure only were found in 66.7%(16/24). Between nodal lymphoma and extra nodal lymphoma, there was no significant survival difference, but extra nodal lymphoma showed higher incidence

  16. Final model independent result of DAMA/LIBRA-phase1

    Energy Technology Data Exchange (ETDEWEB)

    Bernabei, R.; D' Angelo, S.; Di Marco, A. [Universita di Roma ' ' Tor Vergata' ' , Dipartimento di Fisica, Rome (Italy); INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Belli, P. [INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Cappella, F.; D' Angelo, A.; Prosperi, D. [Universita di Roma ' ' La Sapienza' ' , Dipartimento di Fisica, Rome (Italy); INFN, sez. Roma, Rome (Italy); Caracciolo, V.; Castellano, S.; Cerulli, R. [INFN, Laboratori Nazionali del Gran Sasso, Assergi (Italy); Dai, C.J.; He, H.L.; Kuang, H.H.; Ma, X.H.; Sheng, X.D.; Wang, R.G. [Chinese Academy, IHEP, Beijing (China); Incicchitti, A. [INFN, sez. Roma, Rome (Italy); Montecchia, F. [INFN, sez. Roma ' ' Tor Vergata' ' , Rome (Italy); Universita di Roma ' ' Tor Vergata' ' , Dipartimento di Ingegneria Civile e Ingegneria Informatica, Rome (Italy); Ye, Z.P. [Chinese Academy, IHEP, Beijing (China); University of Jing Gangshan, Jiangxi (China)

    2013-12-15

    The results obtained with the total exposure of 1.04 ton x yr collected by DAMA/LIBRA-phase1 deep underground at the Gran Sasso National Laboratory (LNGS) of the I.N.F.N. during 7 annual cycles (i.e. adding a further 0.17 ton x yr exposure) are presented. The DAMA/LIBRA-phase1 data give evidence for the presence of Dark Matter (DM) particles in the galactic halo, on the basis of the exploited model independent DM annual modulation signature by using highly radio-pure NaI(Tl) target, at 7.5{sigma} C.L. Including also the first generation DAMA/NaI experiment (cumulative exposure 1.33 ton x yr, corresponding to 14 annual cycles), the C.L. is 9.3{sigma} and the modulation amplitude of the single-hit events in the (2-6) keV energy interval is: (0.0112{+-}0.0012) cpd/kg/keV; the measured phase is (144{+-}7) days and the measured period is (0.998{+-}0.002) yr, values well in agreement with those expected for DM particles. No systematic or side reaction able to mimic the exploited DM signature has been found or suggested by anyone over more than a decade. (orig.)

  17. Breast carcinoma conservative treatment. Stages I and II

    International Nuclear Information System (INIS)

    Monti, C.R.

    1990-01-01

    From 1981 to 1988, 265 patients with breast cancer stages I and II (UICC-1987), were evaluated after conservative treatment with quadrantectomy plus axillectomy, radiotherapy and chemotherapy. After surgical treatment, the patients were submitted to radiation therapy in the breast. One hundred and fifty six (58,8%) patients were submitted to adjuvant chemotherapy. The median clinical follow-up period was 42.8 months with a minimum of 24 and a maximum of 99 months. Six (2,3%) patients presented local recurrence and 48 (18,1%) presented distant metastasis. After five years the total survival rate was 89,7% and the disease free survival rate was 75% in the same period. The study did not show significant differences among the clinical stages classified after surgery and the use of adjuvant chemotherapy did not influence the results of the many stages. (author). 194 refs, 33 figs, 6 tabs

  18. Advanced Recombinant Manganese Peroxidase for Biosynthesis of Lignin Bioproducts, Phase I Final Report, STTR Grant #: DE-SC0007503.

    Energy Technology Data Exchange (ETDEWEB)

    Beatty, Christopher; Kitner, Joshua; Lajoie, Curtis; McClain, Sean; Potochnik, Steve

    2012-12-13

    The core purpose of this Phase I STTR was to evaluate the feasibility of a new method of producing a recombinant version of manganese peroxidase (MnP) enzyme. MnP is a potentially valuable enzyme for producing high value lignin products and also for industrial de-coloring operations such as biobleaching of pulp and color removal from textile dye effluents. This lignin-modifying enzyme is produced in small amounts by the native host, a white rot fungus. Previous work by Oregon State University developed a secreted recombinant version of the enzyme in the yeast Pichia pastoris. Unfortunately, the expression is barely moderate and the enzyme is heavily glycosylated, which inhibits purification. In this work, the gene for the enzyme is given a tag which targets production of the enzyme to the peroxisome. This is a promising approach since this location is also where heme and hydrogen peroxide are sequestered, which are both necessary cofactors for MnP. More than ten recombinant strains were constructed, verified, and expressed in the Pichia system. Constitutive (GAP) and methanol-induced promoters (AOX) were tried for peroxisomal targeted, cytosolic, and secreted versions of MnP. Only the secreted strains showed activity. The amount of expression was not significantly changed. The degree of glycosylation was lessened using the AOX (methanol) promotoer, but the resulting enzyme was still not able to be purified using immobilized metal affinity chromatography. Additional work beyond the scope of the defined Phase I project was undertaken to construct, verify, and express Pichia strains that mutated the MnP glycosylation sites to inhibit this process. These strains did not show significant activity. The cause is not known, but it is possible that these sites are important to the structure of the enzyme. Also beyond the scope proposed for our Phase I STTR, the team collaborated with AbSci, a startup with a new E. coli based expression system focused on the production of

  19. Pelvic control following external beam radiation for surgical Stage I endometrial adenocarcinoma

    International Nuclear Information System (INIS)

    Rush, Stephen; Gal, David; Potters, Louis; Bosworth, Jay; Lovecchio, John

    1995-01-01

    Purpose: To determine if postoperative external pelvic radiation (EBRT), without vaginal brachytherapy, is sufficient to prevent vaginal cuff and pelvic recurrences in patients with surgical Stage I endometrial adenocarcinoma (ACA). Methods and Materials: The records of 122 patients with surgical Stage I endometrial cancer were reviewed. There were 87 patients with ACA who received EBRT alone and are the subject of this study. Their radiation records were reviewed. All patients underwent exploration, total abdominal hysterectomy, and bilateral salpingo-oophorectomy (TAH BSO), and pelvic and paraaortic lymph node sampling. They were staged according to the FIGO 1988 surgical staging system recommendations. Postoperatively, pelvic EBRT was administered by megavoltage equipment using four fields, to a total dose of 45 to 50.4 Gy. Actuarial survival and disease free survival were calculated according to Kaplan-Meier Method. Results: Twenty-seven patients with Stage IA Grade 1 or 2 ACA with less than one-third myometrial invasion, who did not receive EBRT, and eight patients with histology other than adenocarcinoma (i.e., serous papillary, mucinous, etc.) were not included in the study. For the remaining 87 patients who are in the study group, the median follow-up was 52 months (range: 12-82 months). The 5-year overall survival for these 87 patients was 92%, with a disease-free survival of 83%. There were no tumor recurrences in the upper vagina or in the pelvis. Two patients developed small bowel obstruction (no surgery required), and one patient developed chronic enteritis. Conclusion: Adjuvant external pelvic radiation, without vaginal brachytherapy, prevents pelvic and vaginal cuff recurrences in surgical Stage I endometrial ACA

  20. Seal Analysis for the Ares-I Upper Stage Fuel Tank Manhole Covers

    Science.gov (United States)

    Phillips, Dawn R.; Wingate, Robert J.

    2010-01-01

    Naflex seals have long history of use in launch vehicle components, including Saturn stages and Space Shuttle External Tank. Ares-I Upper Stage tank pressures are higher than ET pressures, requiring performance verification of heritage seal design in new manhole cover configurations. Heritage external tank analyses are reviewed for potential application to Upper Stage.

  1. Accelerating Energy Efficiency in Indian Data Centers. Final Report for Phase I Activities

    Energy Technology Data Exchange (ETDEWEB)

    Ganguly, Suprotim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Raje, Sanyukta [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kumar, Satish [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sartor, Dale [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Greenberg, Steve [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-01-01

    This report documents Phase 1 of the “Accelerating Energy Efficiency in Indian Data Centers” initiative to support the development of an energy efficiency policy framework for Indian data centers. The initiative is being led by the Confederation of Indian Industry (CII), in collaboration with Lawrence Berkeley National Laboratory (LBNL)-U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy, and under the guidance of Bureau of Energy Efficiency (BEE). It is also part of the larger Power and Energy Efficiency Working Group of the US-India Bilateral Energy Dialogue. The initiative consists of two phases: Phase 1 (November 2014 – September 2015) and Phase 2 (October 2015 – September 2016).

  2. The DEBORA-Project: development of borehole seals for high-level radioactive waste. Phase 2. Final report

    International Nuclear Information System (INIS)

    Rothfuchs, T.; Feddersen, H.K.; Kroehn, K.P.; Miehe, R.; Wieczorek, K.; Poley, A.

    1999-12-01

    First numerical simulations of the long-term sealing behaviour of crushed salt backfill in disposal boreholes containing heat producing high-level waste have been performed in phase I of the DEBORA project. The major objective of the project phase II was to confirm the obtained modelling results by comparison with representative experimental data. Two in-situ experiments in 15 m deep boreholes with a diameter of 0.6 m were thus performed in the Asse mine. The experiment DEBORA 1 served for the investigation of the compaction behaviour of crushed salt backfill in the annulus between the heat producing waste canisters and the surrounding rock. In the experiment DEBORA 2 the crushed salt compaction in the seal region above the canister stack was investigated. By electrical heating maximum temperatures of 185 C and 135 C were achieved at the end of the experiments. In both experiments a maximum backfill pressure of about 15 MPa was measured. The convergence induced borehole closure amounted to 15.5 mm and 42.5 mm, respectively. The general agreement between the measured and predicted compaction behaviour was comparably good in both experiments but, the long-term relevant low compaction rates in the final stage of both experiments were predicted even better. It is thus concluded that the material models developed so far allow a satisfactory prediction of the long-term sealing behaviour of crushed salt backfill. Hence, further large scale insitu experiments are not considered necessary. However, some more laboratory investigations are considered useful in order to investigate discrepancies between measurements and predictions observed in particular in the early compaction stage at porosities above 20%. The hydraulic behaviour of the compacting crushed salt was investigated too. The relation k=1.9 x 10 -8 φ 5.27 m 2 between the permeability k and the porosity φ was derived from an evaluation of all in-situ and laboratory data. Former laboratory results are very well

  3. Outcome of radiotherapy for localized stage I E and II E nasal NK/T cell lymphoma

    International Nuclear Information System (INIS)

    Jin Jing; Li Yexiong; Yao Bo; Fang Hui; Liu Xinfan; Zhou Liqiang; Lv Ning; Yu Zihao

    2006-01-01

    Objective: With the optimal therapy remains unclear for nasal NK/T cell lymphoma, the aim of this study is to analyze the outcome of radiotherapy as primary treatment for localized stage I E and II E diseases. Methods: Between January. 1983 and December 2003, 105 patients with stage I E and II E primary nasal NK/T cell lymphoma were retrospectively reviewed. According to the Ann Arbor Staging System, there were 83 stage I E and 22 stage II E. Stage I E was subdivided into limited stage I E confined to the nasal cavity (37 patients), or extensive stage I E with an extension beyond the nasal cavity (46 patients). Thirty-one patients received radiotherapy alone. Thirty-four patients were treated with radiotherapy followed by 2-4 cycles of chemotherapy. Thirty-seven patients were treated with chemotherapy followed by radiotherapy and 3 with chemotherapy alone. Of 83 patients with stage I E disease, 26 were primarily treated with radiotherapy alone, 30 with. radiotherapy followed by chemotherapy, and 27 with chemotherapy followed by radiotherapy. Results: The five-year overall survival (OS) and progression-free survival rates (PIS) for all patients was 71% and 59%, respectively. The 5-year OS for stage I E and stage II E was 78% and 46% (P<0.01), while the 5-year PFS for stage I E and stage II E was 63% and 40%, respectively (P<0.01). Patients with limited stage I E had a better OS and PFS than those with extensive stage I E, with 5-year OS and PFS of 82% and 80% versus 75% and 45%, respectively. Complete response (CR) was achieved in 91 (87%) patients after radiotherapy and/or chemotherapy. Initial radiotherapy resulted in a superior CR as compared to initial chemotherapy, with 54 of 65 (83%) patients achieving CR with initial radiotherapy, versus only 8 of 40 (20%) with initial chemotherapy. For 102 patients who received radiotherapy with or without chemotherapy, the outcome of primary, treatment with radiotherapy alone was compared to that of CMT. Five-year OS and

  4. Efficacies of 125I seed implantation in advanced stage central lung cancer via fibrobronchoscope

    International Nuclear Information System (INIS)

    Liu Jianguo; An Liqing; Cheng Jinguang; Zhang Yufen; Guo Xiaokui

    2009-01-01

    Objective: To explore the temporal curative effect of 125 I seed implantation in advanced stage central type lung cancer. Methods: 125 I seed was implanted in 56 patients confirmed advanced stage central type lung cancer via fibrobronchoscope and all cases were fellow up in certain duration to explore their efficacies and the adverse reaction. Results: Total efficient rate was 76.78% in 56 patients. Lung reexpanded rate was 90.90%. Conclusion: The therapy of 125 I seed implantation in advanced stage central type lung cancer is safe and available. (authors)

  5. Thermal dewatering of lignite: Phase III - final report

    Energy Technology Data Exchange (ETDEWEB)

    Champagne, P J; Szladow, A J; Kybett, B D

    1981-01-01

    Phase III of this project extended the investigation of thermal dewatering on several lignite and peat samples at the temperature range up to 400 degrees C and investigated variables such as retention time, increased rates of heating and cooling, extent of trace element removal, effect of particle size and effect of dewatering under heavy and light oils. Lignites from three areas of Canada (Estevan and Coronach, Saskatchewan, and Onakawana, Ontario) and one peat sample (Garrick, Saskatchewan) were thermally dewatered. The equilibrium moisture values obtained for the dewatered products were as low as, or lower than those obtained in Phases I and II of this project (350 degrees C). However, the measured moisture contents of the thermally dewatered Saskatchewan lignites were somewhat higher than those measured in Phases I and II. The equilibrium moisture values and the moisture contents decreased with increasing temperature. An optimum balance between extent of dewatering and resulting steam pressures is obtained for a dewatering temperature between 300 and 350 degrees C. At these temperatures, residence times in the order of 15 minutes are required. (35 refs.)

  6. Plant and Floret Growth at Distinct Developmental Stages During the Stem Elongation Phase in Wheat

    Directory of Open Access Journals (Sweden)

    Zifeng Guo

    2018-03-01

    Full Text Available Floret development is critical for grain setting in wheat (Triticum aestivum, but more than 50% of grain yield potential (based on the maximum number of floret primordia is lost during the stem elongation phase (SEP, from the terminal spikelet stage to anthesis. Dynamic plant (e.g., leaf area, plant height and floret (e.g., anther and ovary size growth and its connection with grain yield traits (e.g., grain number and width are not clearly understood. In this study, for the first time, we dissected the SEP into seven stages to investigate plant (first experiment and floret (second experiment growth in greenhouse- and field-grown wheat. In the first experiment, the values of various plant growth trait indices at different stages were generally consistent between field and greenhouse and were independent of the environment. However, at specific stages, some traits significantly differed between the two environments. In the second experiment, phenotypic and genotypic similarity analysis revealed that grain number and size corresponded closely to ovary size at anthesis, suggesting that ovary size is strongly associated with grain number and size. Moreover, principal component analysis (PCA showed that the top six principal components PCs explained 99.13, 98.61, 98.41, 98.35, and 97.93% of the total phenotypic variation at the green anther, yellow anther, tipping, heading, and anthesis stages, respectively. The cumulative variance explained by the first PC decreased with floret growth, with the highest value detected at the green anther stage (88.8% and the lowest at the anthesis (50.09%. Finally, ovary size at anthesis was greater in wheat accessions with early release years than in accessions with late release years, and anther/ovary size shared closer connections with grain number/size traits at the late vs. early stages of floral development. Our findings shed light on the dynamic changes in plant and floret growth-related traits in wheat and the

  7. Flammability Assessment Methodology Program Phase I: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    C. A. Loehr; S. M. Djordjevic; K. J. Liekhus; M. J. Connolly

    1997-09-01

    The Flammability Assessment Methodology Program (FAMP) was established to investigate the flammability of gas mixtures found in transuranic (TRU) waste containers. The FAMP results provide a basis for increasing the permissible concentrations of flammable volatile organic compounds (VOCs) in TRU waste containers. The FAMP results will be used to modify the ''Safety Analysis Report for the TRUPACT-II Shipping Package'' (TRUPACT-II SARP) upon acceptance of the methodology by the Nuclear Regulatory Commission. Implementation of the methodology would substantially increase the number of drums that can be shipped to the Waste Isolation Pilot Plant (WIPP) without repackaging or treatment. Central to the program was experimental testing and modeling to predict the gas mixture lower explosive limit (MLEL) of gases observed in TRU waste containers. The experimental data supported selection of an MLEL model that was used in constructing screening limits for flammable VOC and flammable gas concentrations. The MLEL values predicted by the model for individual drums will be utilized to assess flammability for drums that do not meet the screening criteria. Finally, the predicted MLEL values will be used to derive acceptable gas generation rates, decay heat limits, and aspiration time requirements for drums that do not pass the screening limits. The results of the program demonstrate that an increased number of waste containers can be shipped to WIPP within the flammability safety envelope established in the TRUPACT-II SARP.

  8. Short Course Vaginal Cuff Brachytherapy in Treating Patients With Stage I-II Endometrial Cancer

    Science.gov (United States)

    2018-04-17

    Endometrial Clear Cell Adenocarcinoma; Endometrial Endometrioid Adenocarcinoma; Endometrial Serous Adenocarcinoma; Stage I Uterine Corpus Cancer; Stage IA Uterine Corpus Cancer; Stage IB Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Uterine Corpus Carcinosarcoma; Uterine Corpus Sarcoma

  9. Near-term electric vehicle program: Phase I, final report

    Energy Technology Data Exchange (ETDEWEB)

    Rowlett, B. H.; Murry, R.

    1977-08-01

    A final report is given for an Energy Research and Development Administration effort aimed at a preliminary design of an energy-efficient electric commuter car. An electric-powered passenger vehicle using a regenerative power system was designed to meet the near-term ERDA electric automobile goals. The program objectives were to (1) study the parameters that affect vehicle performance, range, and cost; (2) design an entirely new electric vehicle that meets performance and economic requirements; and (3) define a program to develop this vehicle design for production in the early 1980's. The design and performance features of the preliminary (baseline) electric-powered passenger vehicle design are described, including the baseline power system, system performance, economic analysis, reliability and safety, alternate designs and options, development plan, and conclusions and recommendations. All aspects of the baseline design were defined in sufficient detail to verify performance expectations and system feasibility.

  10. Systems Support Mapping in Guiding Self-Management in Stage I-III Colorectal Cancer Survivors

    Science.gov (United States)

    2018-04-26

    Cancer Survivor; Stage I Colorectal Cancer AJCC v8; Stage II Colorectal Cancer AJCC v8; Stage IIA Colorectal Cancer AJCC v8; Stage IIB Colorectal Cancer AJCC v8; Stage IIC Colorectal Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8

  11. Final phases of stellar evolution and the supernova phenomenon

    Energy Technology Data Exchange (ETDEWEB)

    Gallino, R [Torino, Universita, Turin, Italy; Masani, A [CNR, Laboratorio di Cosmo-geofisica, Turin, Italy

    1977-12-01

    Various theoretical aspects of the final stages of stellar evolution are reviewed in the framework of gravitational collapse and thermonuclear reactions (C-12 and O-16) in degenerate electron conditions. Attention is given to the evolution of supermassive stars, massive stars, and low-mass stars and to such topics as neutrino emission in intermediate-mass stars, white-dwarf supernovae, rotational instability, and stellar collisions and eclipsing binary systems.

  12. Installation and Commissioning of the CMS Hadron Forward Calorimeters Phase I Upgrade

    CERN Document Server

    Onel, Yasar

    2017-01-01

    The final phase of the CMS Hadron Forward Calorimeters Phase I upgrade was performed during the Extended Year End Technical Stop of 2016-2017. In the framework of the upgrade, the PMT boxes were reworked to implement two channel readout in order to exploit the benefits of the multi-anode PMTs in background tagging and signal recovery. The front-end electronics was also being upgraded to QIE10-based electronics which will implement larger dynamic range and a 6-bit TDC to provide additional handles to eliminate the background. Following this major upgrade, the Hadron Forward Calorimeters are being commissioned for operation readiness in 2017. Here we describe the details and the components of the upgrade, and discuss the operational experience and results obtained during the upgrade and commissioning.

  13. Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.

    Science.gov (United States)

    Cerecetto, Hugo; González, Mercedes

    2010-03-25

    Chagas' disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the "active-to-hit" stage. However, only a more limited number of these have been studied in vivo in models of Chagas' disease. Herein, we survey some of the cantidates able to surpass the "hit-to-lead" stage discussing their limitations or merit to enter in clinical trials in the short term.

  14. Study of percutaneous 125I seeds implantation guided by CT in elderly patients of stage I peripheral non-small cell lung cancer

    International Nuclear Information System (INIS)

    Ke Mingyao; Yong Yazhi; Luo Bingqing; Wu Xuemei; Chen Lingling; Xie Hongqi

    2011-01-01

    Objective: To evaluate the efficacy, feasibility and safety of CT guided percutaneous 125 I seeds implantation in elderly patients of stage I peripheral non-small cell lung cancer (NSCLC). Methods: Clinical data of 16 elderly peripheral stage I NSCLC patients (10 squamous carcinoma and 6 adenocarcinoma; 13 stage I A and 3 stage I B ) who received radioactive 125 I seeds implantation because of refusal or being unsuited to operation or external radiotherapy were retrospectively analyzed. Prescribed dose was 140 - 160 Gy. Under CT guidance, 125 I seeds were implanted percutaneously into tumors for interstitial radiotherapy according to treatment plan system. Results: Mean number of 125 I seeds each patient received was 21.1. 12 complete response (CR) and 4 partial response (PR) were achieved. Total response rate (CR + PR) was 100%. 100% patients completed 10 to 56 months of follow-up, 15, 13, 8 and 6 patients completed 1-, 2-, 3-and 4-years' follow-up, respectively. The median local progression free time was 14 months. The 1-, 2-, 3-and 4-year overall survival rate were 60%, 54%, 50% and 33%, respectively (median : 14 months). 7 cases died of non-tumor disease and 5 died of metastasis. No severe complications were observed. Conclusions: CT guided 125 I seeds implantation is a safe, reliable and effective radical treatment method for elderly stage I peripheral NSCLC patients, who refuse to or are unsuitable to operation or external radiotherapy. (authors)

  15. High Input Voltage Hall Thruster Discharge Converter, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall scope of this Phase I/II effort is the development of a high efficiency 15kW (nominal) Hall thruster discharge converter. In Phase I, Busek Co. Inc. will...

  16. Radiotherapy and chemotherapy in stages I and II non-Hodgkin's lymphomas of Waldeyer's ring

    International Nuclear Information System (INIS)

    Hayabuchi, Naofumi; Jingu, Kenichi; Miyoshi, Makoto; Akasi, Yuko; Masuda, Koji; Komiyama, Sotaro; Kikuchi, Masahiro.

    1990-01-01

    Sixty-four patients with stages I and II non-Hodgkin's lymphomas (NHL) involving Waldeyer's ring treated between 1970 and 1987 were reviewed. Patients with stage II NHL were subdivided into stage II1 (limited type) and stage II2 (advanced type) from the state of neck nodes. Stage II1 was defined as involvement of unilateral cervical nodes less than 4 cm in diameter as well as Waldeyer's ring involvement. Other stage II cases were classified as stage II2. All 17 patients with stage I HNL were treated with radiation therapy alone. Their diseases were well controlled, and none of them died of causes related to the lymphoma. Among 14 patients with stage II1 NHL, the 5-year survival rate for the 9 patients treated with radiation therapy alone was 87.5%. Until 1982, 19 of 21 patients with stage II2 NHL treated with radiation therapy alone or radiation therapy and adjuvant chemotherapy (VEMP or COPP) died within 5 years mainly of disseminated diseases. Since 1983, CHOP had been used as the main treatment as well as radiotherapy for the 12 stage II2 NHL patients. So far, only 3 of them relapsed and 2 of them died of causes related to the lymphoma. Only 1 of these 12 patients was T-cell lymphoma compared to 7 of 9 stage II2 patients before 1982. This suggests that patients with stage I and those with limited stage II can be safely treated with radiotherapy. Also aggressive chemotherapy as well as radiotherapy should be used for patients with advanced stage II HNL involving Waldeyer's ring. (author)

  17. A phase I study of postoperative concurrent radiotherapy and oral doxifluridine and leucovorin for II/III stage rectal cancer

    International Nuclear Information System (INIS)

    Jin Jing; Li Yexiong; Tang Yuan; Wang Weihu; Wang Shulian; Song Yongwen; Liu Yueping; Yu Zihao; Liu Xinfan

    2008-01-01

    Objective: A phase I study was conducted to determine the maximal tolerated dose (MTD) and the dose-limiting toxicity (DLT) of chemotherapy of oral doxifluridine (5-dFUR) and leucovorin with concurrent standard radiotherapy(RT) as adjuvant treatment in patients with rectal cancer. Methods: Patients aged 18-75 years old, Kamofsky scored ≥70%, stage II/III rectal cancer after curative surgery were eligible. Total RT dose was delivered as DT 50 Gy in the fraction of 2.0 Gy per day for 5 weeks to the pelvic area. 5-dFUR was administered concurrently with radiotherapy in escalating doses, and oral leucovorin was administered in a fixed dose of 30 mg/(m 2 ·d), both 3 times daily, from the 1 st day of RT to the last day. The DLTs included grade 3 or grade 4 hematologic and nonhematologie toxicity. Results: From Aug. 2005 to Mar. 2007, 16 patients were enrolled at the following dose levels: 450 mg/(m 2 ·d) (3 patients), 550 mg/(m 2 ·d) (6 patients) and 650 mg/(m 2 ·d) (7 patients). Diarrhea, neutropenia and nausea/vomit were the most common side effects although all neutropenia was less grade 3. The DLT was observed in 1 patient at 550 mg/(m 2 ·d) (grade 4 diarrhea), but none in the following 3 patients at the same dose level. At 650 mg/(m 2 ·d) level, the first patient quitted the study due to a severe abdominal cramp pain in the 3rd week of RT. In the following 3 enrolled patients, one suffered grade 3 abdominal cramp pain, diarrhea, fatigue, nausea/vomit and grade 2 neutropenia and fever. Grade 3 diarrhea was also observed in all the additional 3 patients at 650 mg/(m 2 ·d) dose level. So the dose escalation was ended up to 650 mg/(m 2 ·d). Four of 16 patients didn't complete the scheduled concurrent chemoradiotherapy due to severe side effects, including 1 at 550 mg/(m 2 ·d) dose level, and 3 at 650 mg/(m 2 ·d). The DLTs were observed as grade 3/4 diarrhea, grade 3 abdominal cramp pain, fatigue and nausea/vomit. Conclusions: Diarrhea is the most common and

  18. Crack-tip chemistry modeling of stage I stress corrosion cracking

    International Nuclear Information System (INIS)

    Jones, R.H.; Simonen, E.P.

    1991-10-01

    Stage I stress corrosion cracking usually exhibits a very strong K dependence with Paris law exponents of up to 30. 2 Model calculations indicate that the crack velocity in this regime is controlled by transport through a salt film and that the K dependence results from crack opening controlled salt film dissolution. An ionic transport model that accounts for both electromigration through the resistive salt film and Fickian diffusion through the aqueous solution was used for these predictions. Predicted crack growth rates are in excellent agreement with measured values for Ni with P segregated to the grain boundaries and tested in IN H 2 SO 4 at +900 mV. This salt film dissolution may be applicable to stage I cracking of other materials

  19. Diffusion of Cu+ in β-phase CuI

    International Nuclear Information System (INIS)

    Johansson, J.X.M.Z.; Skoeld, K.; Joergensen, J.E.

    1992-01-01

    Measurements of ionic diffusion of Cu + in solid CuI in the β-phase is carried out with a non-destructive radioactive tracer technique, utilizing coincidence counting of the annihilation gammas from the positron decay of 64 Cu. The diffusion coefficient and the activation energy for the diffusion are evaluated. The experimental results show distinct diffusion character in the β-phase which differs from those in the γ- and α-phases. The β-phase diffusion properties together with the previous results for γ-and α-phases will provide valuable guidance for MD calculations, in which the diffusion coefficients and activation energies have been overestimated and the γ-β phase transition does not appear. The ionic conductivity of CuI estimated from tracer diffusion results and the Nernst-Einstein relation are compared with values from electro-chemical methods. In all three phases the conductivities obtained from electro-chemical methods are much lower than those calculated from the measured tracer diffusion coefficients. (author). 7 refs.; 4 figs.; 2 tabs

  20. Research for the energy turnaround. Phase transitions actively shape. Contributions

    International Nuclear Information System (INIS)

    Szczepanski, Petra; Wunschick, Franziska; Martin, Niklas

    2015-01-01

    The Annual Conference 2014 of the Renewable Energy Research Association was held in Berlin on 6 and 7 November 2014. This book documents the contributions of the conference on research for the energy turnaround, phase transitions actively shape. After an introduction and two contributions to the political framework, the contributions to the economic phases of the energy transition, the phase of the current turn, the phases of social energy revolution, the stages of heat turnaround (Waermewende), and the stages of the mobility turn deal with the stages of development of the energy system. Finally, the Research Association Renewable Energy is briefly presented. [de

  1. Lightweight Exit Cone for Liquid Rocket Engines, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Pratt and Whitney Rocketdyne (PWR) J-2X engine will power the upper stage of the Ares I and the earth departure stage (EDS) of the Ares V, which will enable...

  2. A combined heating cooling stage for cluster thermalization in the gas phase

    International Nuclear Information System (INIS)

    Ievlev, D.N.; Kuester, A.; Enders, A.; Malinowski, N.; Schaber, H.; Kern, K.

    2003-01-01

    We report on the design and performance of a combined heating/cooling stage for the thermalization of clusters in a gas phase time-of-flight mass spectrometer. With this setup the cluster temperature can sensitively be adjusted within the range from 100 up to 800 K and higher. The unique combination of a heating stage with a subsequent cooling stage allows us to perform thermodynamic investigations on clusters at very high temperatures without quality losses in the spectra due to delayed fragmentation in the drift tube of the mass spectrometer. The performance of the setup is demonstrated by the example of (C 60 ) n clusters

  3. Relapse and Mortality Risk of Stage I Testicular Cancer

    DEFF Research Database (Denmark)

    Florvall, Cecilia; Frederiksen, Peder; Lauritsen, Jakob

    2017-01-01

    OBJECTIVES: - To assess the medical insurance risk for patients with stage I testicular cancer (TC), by calculating the overall mortality risk with and without relapse, and compare it to men from the Danish population. BACKGROUND: - Testicular cancer is the most common malignancy in young males...

  4. Developing an inventor support service which performs early stage market and manufacturing evaluations. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

  5. Developing an inventor support service which performs early stage market and manufacturing evaluations. [Final Report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

  6. Prototypical spent nuclear fuel rod consolidation equipment: Phase 2, Final design report: Volume 1, Detailed design

    International Nuclear Information System (INIS)

    Blissell, W.H.; Ciez, A.P.; Goedicke, F.E.; Bessko, C.

    1987-01-01

    This document describes the Westinghouse Final Design for the Prototypical Spent Fuel Consolidation Equipment Demonstration Project. This design represents a fully qualified, licensable, cost effective spent fuel rod consolidation system. As a result of significant concerns raised by DOE and its Technical Review Committee during the 30% Design Review, significant changes were made to the original Preliminary Design resulting from Phase I activities. These changes focused on increased automation, end fitting removal, the rod pulling process and the need to maintain the consolidation canisters as clean as possible. As a result of these changes, the new system is greatly enhanced with a much greater probability of meeting or exceeding the project functional requirements. As a result of delays in resolving cost and contractual differences, additional bench testing was not conducted during Phase II. It is however our belief that the current design exceeds the 90% confidence level required by DOE because of the confidence gained from the Phase I tests, the additional engineering detail completed and the fact that our rod pulling tool has been demonstrated in a similar application at Oconee while our ID tube cutter is a modified (mounting method only) off-the-shelf design. 7 refs., 49 figs., 36 tabs

  7. Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or Stage II Breast Cancer

    Science.gov (United States)

    2011-12-07

    Ductal Breast Carcinoma in Situ; Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; HER2-negative Breast Cancer; HER2-positive Breast Cancer; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Male Breast Cancer; Medullary Ductal Breast Carcinoma With Lymphocytic Infiltrate; Mucinous Ductal Breast Carcinoma; Papillary Ductal Breast Carcinoma; Progesterone Receptor-negative Breast Cancer; Progesterone Receptor-positive Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Tubular Ductal Breast Carcinoma

  8. Molten salt steam generator subsystem research experiment. Volume I. Phase 1 - Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-10-01

    A study was conducted for Phase 1 of a two-phase project whose objectives were to develop a reliable, cost-effective molten salt steam generating subsystem for solar thermal plants, minimize uncertainty in capital, operating, and maintenance costs, and demonstrate the ability of molten salt to generate high-pressure, high-temperature steam. The Phase 1 study involved the conceptual design of molten salt steam generating subsystems for a nominal 100-MWe net stand-alone solar central receiver electric generating plant, and a nominal 100-MWe net hybrid fossil-fueled electric power generating plant that is 50% repowered by a solar central receiver system. As part of Phase 1, a proposal was prepared for Phase 2, which involves the design, construction, testing and evaluation of a Subsystem Research Experiment of sufficient size to ensure successful operation of the full-size subsystem designed in Phase 1. Evaluation of several concepts resulted in the selection of a four-component (preheater, evaporator, superheater, reheater), natural circulation, vertically oriented, shell and tube (straight) heat exchanger arrangement. Thermal hydraulic analysis of the system included full and part load performance, circulation requirements, stability, and critical heat flux analysis. Flow-induced tube vibration, tube buckling, fatigue evaluation of tubesheet junctions, steady-state tubesheet analysis, and a simplified transient analysis were included in the structural analysis of the system. Operating modes and system dynamic response to load changes were identified. Auxiliary equipment, fabrication, erection, and maintenance requirements were also defined. Installed capital costs and a project schedule were prepared for each design.

  9. System design description for master equipment list, phase I

    International Nuclear Information System (INIS)

    Sandoval, J.D.

    1997-01-01

    This System Design Description (SDD) is for the Master Equipment List Phase I (MEL). It has been prepared following the WI-IC-CM-3-10, ''Software Practices,'' (Ref. 6). This SDD describes the internal design for implementation of the MEL Phase I

  10. Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

    International Nuclear Information System (INIS)

    Wada, Nobuyuki; Rino, Yasushi; Masuda, Munetaka; Ito, Koichi; Sugino, Kiminori; Mimura, Takashi; Nagahama, Mitsuji; Kitagawa, Wataru; Shibuya, Hiroshi; Ohkuwa, Keiko; Nakayama, Hirotaka; Hirakawa, Shohei

    2009-01-01

    To examine the outcomes and risk factors in pediatric differentiated thyroid carcinoma (DTC) patients who were defined as TNM stage I because some patients develop disease recurrence but treatment strategy for such stage I pediatric patients is still controversial. We reviewed 57 consecutive TNM stage I patients (15 years or less) with DTC (46 papillary and 11 follicular) who underwent initial treatment at Ito Hospital between 1962 and 2004 (7 males and 50 females; mean age: 13.1 years; mean follow-up: 17.4 years). Clinicopathological results were evaluated in all patients. Multivariate analysis was performed to reveal the risk factors for disease-free survival (DFS) in these 57 patients. Extrathyroid extension and clinical lymphadenopathy at diagnosis were found in 7 and 12 patients, respectively. Subtotal/total thyroidectomy was performed in 23 patients, modified neck dissection in 38, and radioactive iodine therapy in 10. Pathological node metastasis was confirmed in 37 patients (64.9%). Fifteen patients (26.3%) exhibited local recurrence and 3 of them also developed metachronous lung metastasis. Ten of these 15 achieved disease-free after further treatments and no patients died of disease. In multivariate analysis, male gender (p = 0.017), advanced tumor (T3, 4a) stage (p = 0.029), and clinical lymphadenopathy (p = 0.006) were risk factors for DFS in stage I pediatric patients. Male gender, tumor stage, and lymphadenopathy are risk factors for DFS in stage I pediatric DTC patients. Aggressive treatment (total thyroidectomy, node dissection, and RI therapy) is considered appropriate for patients with risk factors, whereas conservative or stepwise approach may be acceptable for other patients

  11. Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer

    Science.gov (United States)

    2018-05-30

    Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage IA Breast Cancer AJCC v8; Anatomic Stage IB Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Grade 1 Peripheral Motor Neuropathy, CTCAE; Grade 1 Peripheral Sensory Neuropathy, CTCAE; Grade 2 Peripheral Motor Neuropathy, CTCAE; Grade 2 Peripheral Sensory Neuropathy, CTCAE; Prognostic Stage I Breast Cancer AJCC v8; Prognostic Stage IA Breast Cancer AJCC v8; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8

  12. Electromagnetic acoustic transducer (EMAT) defect characterization of nuclear reactor piping welds. Phase I. Final report, October 1985-March 1986

    International Nuclear Information System (INIS)

    Davis, T.J.; Thome, D.K.

    1986-05-01

    The Phase I workscope was successfully completed. This work was directed at determining the most promising methods for application of EMATs to stainless steel piping examination. It consisted of a literature review, evaluation of shear and longitudinal wave inspection modes, and evaluation of several signal processing techniques to enhance signal/noise ratios. The work involved both hardware and software development. A high degree of success was obtained during the course of the work, indicating that further exploitation of the technique is fully warranted. Defects as small as 0.1 cm deep could be detected in wrought stainless piping, and the ability to detect defects in thick centrifugally cast stainless samples was demonstrated. In addition, the techniques showed promise for sizing the flaws. These results were achieved through a combination of synthetic aperture processing, temporal averaging and low frequency illumination. Additional techniques were evaluated, including frequency analysis, angle beam scanning and multimode inspection, but were shown to be of limited benefit for the samples available in Phase I. However, these techniques may offer potential for discriminating between cracks and geometric reflectors. 56 refs., 21 figs

  13. Compact, Ultrasensitive Formaldehyde Monitor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase I proposal seeks to develop an ultrasensitive, laser-based formaldehyde gas sensor system for airborne and ground-based...

  14. All optical vector magnetometer, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research project will investigate a novel method of operating an atomic magnetometer to simultaneously measure total magnetic fields and vector magnetic...

  15. Architecture-Based Reuse Innovations, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I proposal responds to the Solicitation requirements by scoping the effort involved in developing a common software executive and aligned library of...

  16. Prototypical spent nuclear nuclear fuel rod consolidation equipment, Phase 2: Final design report: Volume 2, Appendices: Part 1

    International Nuclear Information System (INIS)

    Ciez, A.P.

    1987-01-01

    The purpose of this specification is to establish functional and design requirements for the Prototypical Spent Nuclear Fuel Rod Consolidation System. The Department of Energy-Idaho Operations Office (DOE-ID) is responsible for the implementation of the Prototypic Dry Rod Consolidation Demonstration Project. This program is to develop and demonstrate a fully qualified, licensable, cost-effective, dry spent fuel rod consolidation system by July 1989. The work is divided into four phases as follows: Phase I--Preliminary Design, Phase II--Final Design Option, Phase III--Fabrication and System Checkout Option, and Phase IV--Installation and Hot Demonstration Option. This specification is part of the Phase II effort. The objectives of this specification are to provide functional and design requirements for the Prototypical Spent Nuclear Fuel Rod Consolidation equipment; establish specific tool and subsystem requirements such that the integrated and overall system requirements are satisfied; and establish positioning, envelope and size interface control requirements for each tool or subsystem such that the individual components will interface properly with the overall system design

  17. Reactive Power Control of Single-Stage Three-Phase Photovoltaic System during Grid Faults Using Recurrent Fuzzy Cerebellar Model Articulation Neural Network

    Directory of Open Access Journals (Sweden)

    Faa-Jeng Lin

    2014-01-01

    Full Text Available This study presents a new active and reactive power control scheme for a single-stage three-phase grid-connected photovoltaic (PV system during grid faults. The presented PV system utilizes a single-stage three-phase current-controlled voltage-source inverter to achieve the maximum power point tracking (MPPT control of the PV panel with the function of low voltage ride through (LVRT. Moreover, a formula based on positive sequence voltage for evaluating the percentage of voltage sag is derived to determine the ratio of the injected reactive current to satisfy the LVRT regulations. To reduce the risk of overcurrent during LVRT operation, a current limit is predefined for the injection of reactive current. Furthermore, the control of active and reactive power is designed using a two-dimensional recurrent fuzzy cerebellar model articulation neural network (2D-RFCMANN. In addition, the online learning laws of 2D-RFCMANN are derived according to gradient descent method with varied learning-rate coefficients for network parameters to assure the convergence of the tracking error. Finally, some experimental tests are realized to validate the effectiveness of the proposed control scheme.

  18. Second Law Violation By Magneto-Caloric Effect Adiabatic Phase Transition of Type I Superconductive Particles

    Directory of Open Access Journals (Sweden)

    Peter Keefe

    2004-03-01

    Full Text Available Abstract: The nature of the thermodynamic behavior of Type I superconductor particles, having a cross section less than the Ginzburg-Landau temperature dependent coherence length is discussed for magnetic field induced adiabatic phase transitions from the superconductive state to the normal state. Argument is advanced supporting the view that when the adiabatic magneto-caloric process is applied to particles, the phase transition is characterized by a decrease in entropy in violation of traditional formulations of the Second Law, evidenced by attainment of a final process temperature below that which would result from an adiabatic magneto-caloric process applied to bulk dimensioned specimens.

  19. Crew Cerebral Oxygen Monitor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR proposal is aimed at developing a non-invasive, optical method for monitoring the state of consciousness of crew members in operational...

  20. Magnetically Modified Asymmetric Supercapacitors, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project is for the development of an asymmetric supercapacitor that will have improved energy density and cycle life....

  1. ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment | Division of Cancer Prevention

    Science.gov (United States)

    This randomized phase IIb trial studies how well ACTOplus met XR works in treating in patients with stage I-IV oral cavity or oropharynx cancer that are undergoing definitive treatment. Chemoprevention is the use of drugs to keep oral cavity or oropharynx cancer from forming or coming back. The use of ACTOplus met XR may slow disease progression in patients with oral cavity or

  2. OECD/NEA Sandia Fuel Project phase I: Benchmark of the ignition testing

    Energy Technology Data Exchange (ETDEWEB)

    Adorni, Martina, E-mail: martina_adorni@hotmail.it [UNIPI (Italy); Herranz, Luis E. [CIEMAT (Spain); Hollands, Thorsten [GRS (Germany); Ahn, Kwang-II [KAERI (Korea, Republic of); Bals, Christine [GRS (Germany); D' Auria, Francesco [UNIPI (Italy); Horvath, Gabor L. [NUBIKI (Hungary); Jaeckel, Bernd S. [PSI (Switzerland); Kim, Han-Chul; Lee, Jung-Jae [KINS (Korea, Republic of); Ogino, Masao [JNES (Japan); Techy, Zsolt [NUBIKI (Hungary); Velazquez-Lozad, Alexander; Zigh, Abdelghani [USNRC (United States); Rehacek, Radomir [OECD/NEA (France)

    2016-10-15

    Highlights: • A unique PWR spent fuel pool experimental project is analytically investigated. • Predictability of fuel clad ignition in case of a complete loss of coolant in SFPs is assessed. • Computer codes reasonably estimate peak cladding temperature and time of ignition. - Abstract: The OECD/NEA Sandia Fuel Project provided unique thermal-hydraulic experimental data associated with Spent Fuel Pool (SFP) complete drain down. The study conducted at Sandia National Laboratories (SNL) was successfully completed (July 2009 to February 2013). The accident conditions of interest for the SFP were simulated in a full scale prototypic fashion (electrically heated, prototypic assemblies in a prototypic SFP rack) so that the experimental results closely represent actual fuel assembly responses. A major impetus for this work was to facilitate severe accident code validation and to reduce modeling uncertainties within the codes. Phase I focused on axial heating and burn propagation in a single PWR 17 × 17 assembly (i.e. “hot neighbors” configuration). Phase II addressed axial and radial heating and zirconium fire propagation including effects of fuel rod ballooning in a 1 × 4 assembly configuration (i.e. single, hot center assembly and four, “cooler neighbors”). This paper summarizes the comparative analysis regarding the final destructive ignition test of the phase I of the project. The objective of the benchmark is to evaluate and compare the predictive capabilities of computer codes concerning the ignition testing of PWR fuel assemblies. Nine institutions from eight different countries were involved in the benchmark calculations. The time to ignition and the maximum temperature are adequately captured by the calculations. It is believed that the benchmark constitutes an enlargement of the validation range for the codes to the conditions tested, thus enhancing the code applicability to other fuel assembly designs and configurations. The comparison of

  3. The Cryogenic Design of the Phase I Upgrade Inner Triplet Magnets for LHC

    CERN Document Server

    van Weelderen, R; Peterson, T

    2011-01-01

    The LHC is operating with beam since end 2009. However, with the present interaction region magnets it cannot reach its nominal performance and a phased approach to upgrading them to reach that nominal performance is taken. The first phase of the LHC interaction region upgrade was approved by Council in December 2007. This phase relies on the mature Nb-Ti superconducting magnet technology with the target of increasing the LHC luminosity to 2 to 3×1034 cm-2s-1, while relying on the existing infrastructure which limits the total heat removal capacity at 1.9 K to 500 W. The Phase I Upgrade LHC interaction region final focus magnets will include four superconducting quadrupoles (low-β triplets) and one superconducting dipole (D1) cooled with pressurized, static superfluid helium (HeII) at 1.9 K. The heat absorbed in pressurized HeII, which may be more than 30 W/m due to dynamic heating from the particle beam halo, will be conducted to saturated He II at about 1.9 K and removed by the low pressure vapour. This p...

  4. 40 CFR 76.12 - Phase I NOX compliance extension.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Phase I NOX compliance extension. 76.12 Section 76.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) ACID RAIN NITROGEN OXIDES EMISSION REDUCTION PROGRAM § 76.12 Phase I NOX compliance extension. (a...

  5. The relation between lymph node status and survival in Stage I-III colon cancer

    DEFF Research Database (Denmark)

    Lykke, J.; Roikjær, Ole; Jess, P.

    2013-01-01

    Aim: This study involved a large nationwide Danish cohort to evaluate the hypothesis that a high lymph node harvest has a positive effect on survival in curative resected Stage I-III colon cancer and a low lymph node ratio has a positive effect on survival in Stage III colon cancer. Method......: Analysis of overall survival was conducted using a nationwide Danish cohort of patients treated with curative resection of Stage I-III colon cancer. All 8901 patients in Denmark diagnosed with adenocarcinoma of the colon and treated with curative resection in the period 2003-2008 were identified from...... independent prognostic factors in multivariate analysis. Conclusion: High lymph node count was associated with improved overall survival in colon cancer. Lymph node ratio was superior to N-stage in differentiating overall survival in Stage III colon cancer. Stage migration was observed....

  6. Stir Friction Welding Used in Ares I Upper Stage Fabrication

    Science.gov (United States)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts friction stir welding used in manufacturing aluminum panels that will fabricate the Ares I upper stage barrel. The panels are subjected to confidence tests in which the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  7. Slow and Fast Light, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In response to the NASA Small Business Innovation Research (SBIR) Program 2015 Phase I Solicitation S3.08: Slow and Fast Light, Torch Technologies in partnership...

  8. Comparison of pelvic phased-array versus endorectal coil magnetic resonance imaging at 3 Tesla for local staging of prostate cancer.

    Science.gov (United States)

    Kim, Bum Soo; Kim, Tae-Hwan; Kwon, Tae Gyun; Yoo, Eun Sang

    2012-05-01

    Several studies have demonstrated the superiority of endorectal coil magnetic resonance imaging (MRI) over pelvic phased-array coil MRI at 1.5 Tesla for local staging of prostate cancer. However, few have studied which evaluation is more accurate at 3 Tesla MRI. In this study, we compared the accuracy of local staging of prostate cancer using pelvic phased-array coil or endorectal coil MRI at 3 Tesla. Between January 2005 and May 2010, 151 patients underwent radical prostatectomy. All patients were evaluated with either pelvic phased-array coil or endorectal coil prostate MRI prior to surgery (63 endorectal coils and 88 pelvic phased-array coils). Tumor stage based on MRI was compared with pathologic stage. We calculated the specificity, sensitivity and accuracy of each group in the evaluation of extracapsular extension and seminal vesicle invasion. Both endorectal coil and pelvic phased-array coil MRI achieved high specificity, low sensitivity and moderate accuracy for the detection of extracapsular extension and seminal vesicle invasion. There were statistically no differences in specificity, sensitivity and accuracy between the two groups. Overall staging accuracy, sensitivity and specificity were not significantly different between endorectal coil and pelvic phased-array coil MRI.

  9. Predictive Software Cost Model Study. Volume I. Final Technical Report.

    Science.gov (United States)

    1980-06-01

    development phase to identify computer resources necessary to support computer programs after transfer of program manangement responsibility and system... classical model development with refinements specifically applicable to avionics systems. The refinements are the result of the Phase I literature search

  10. Stage I surface crack formation in thermal fatigue: A predictive multi-scale approach

    International Nuclear Information System (INIS)

    Osterstock, S.; Robertson, C.; Sauzay, M.; Aubin, V.; Degallaix, S.

    2010-01-01

    A multi-scale numerical model is developed, predicting the formation of stage I cracks, in thermal fatigue loading conditions. The proposed approach comprises 2 distinct calculation steps. Firstly, the number of cycles to micro-crack initiation is determined, in individual grains. The adopted initiation model depends on local stress-strain conditions, relative to sub-grain plasticity, grain orientation and grain deformation incompatibilities. Secondly, 2-4 grains long surface cracks (stage I) is predicted, by accounting for micro-crack coalescence, in 3 dimensions. The method described in this paper is applied to a 500 grains aggregate, loaded in representative thermal fatigue conditions. Preliminary results provide quantitative insight regarding position, density, spacing and orientations of stage I surface cracks and subsequent formation of crack networks. The proposed method is fully deterministic, provided all grain crystallographic orientations and micro-crack linking thresholds are specified. (authors)

  11. Self-Healing Inflatable Extraterrestrial Shield (SHIELD), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The team of Astro Terra Corp, Virginia Commonwealth University (VCU), and Virginia Tech (VT) propose the development of a composite polymer over Phase-I and Phase-II...

  12. Patterns of care in the management of seminoma stage I

    DEFF Research Database (Denmark)

    Vossen, Carla Y; Horwich, Alan; Daugaard, Gedske

    2012-01-01

    Study Type - Therapy (practise pattern survey). Level of Evidence 3b. What's known on the subject? and What does the study add? The uncertainties about differences in relapse and rates of other late events such as second malignancy and cardiovascular events for the three post-orchidectomy strateg......Study Type - Therapy (practise pattern survey). Level of Evidence 3b. What's known on the subject? and What does the study add? The uncertainties about differences in relapse and rates of other late events such as second malignancy and cardiovascular events for the three post......-orchidectomy strategies in seminoma stage I patients has led to debates about whether the three strategies are equally effective and safe. The differences in interpretation of the data as well as the debates are likely to result in differences in treatment after orchidectomy in seminoma stage I patient management...

  13. Status report of the GERDA experiment phase I

    International Nuclear Information System (INIS)

    Riboldi, Stefano

    2013-01-01

    Phase I of GERDA, aimed at investigating neutrino-less double beta decay of 76 Ge is in the active phase since November 2011 at the Gran Sasso National Laboratory of INFN—Italy. GERDA Ge detectors are non-encapsulated and operate immersed in liquid argon, equipped with a front-end readout electronics consisting of cryogenic charge sensitive preamplifiers designed and manufactured to cope with the characteristics of the GERDA experiment (radio-purity, long and resistive cables, etc.). The presentation will report on the current status of the GERDA experiment phase I, focusing on Ge detectors performance in terms of energy resolution, stability over time, counting rate and related issues

  14. Status report of the GERDA experiment phase I

    Energy Technology Data Exchange (ETDEWEB)

    Riboldi, Stefano, E-mail: stefano.riboldi@mi.infn.it [Universita' degli Studi di Milano and INFN, Milano (Italy)

    2013-08-01

    Phase I of GERDA, aimed at investigating neutrino-less double beta decay of {sup 76}Ge is in the active phase since November 2011 at the Gran Sasso National Laboratory of INFN—Italy. GERDA Ge detectors are non-encapsulated and operate immersed in liquid argon, equipped with a front-end readout electronics consisting of cryogenic charge sensitive preamplifiers designed and manufactured to cope with the characteristics of the GERDA experiment (radio-purity, long and resistive cables, etc.). The presentation will report on the current status of the GERDA experiment phase I, focusing on Ge detectors performance in terms of energy resolution, stability over time, counting rate and related issues.

  15. Status report of the GERDA experiment phase I

    Science.gov (United States)

    Riboldi, Stefano; Gerda Collaboration

    2013-08-01

    Phase I of GERDA, aimed at investigating neutrino-less double beta decay of 76Ge is in the active phase since November 2011 at the Gran Sasso National Laboratory of INFN-Italy. GERDA Ge detectors are non-encapsulated and operate immersed in liquid argon, equipped with a front-end readout electronics consisting of cryogenic charge sensitive preamplifiers designed and manufactured to cope with the characteristics of the GERDA experiment (radio-purity, long and resistive cables, etc.). The presentation will report on the current status of the GERDA experiment phase I, focusing on Ge detectors performance in terms of energy resolution, stability over time, counting rate and related issues.

  16. Two-phase flow in a saliniferous final repository using the example of ERAM. Final report; Zweiphasenfluss in einem salinaren Endlager am Beispiel des ERAM. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Kock, Ingo; Frieling, Gerd; Navarro, Martin

    2016-10-15

    In the frame of the research project ZIESEL the GRS enhanced the state of science and technology for the realization and evaluation of long-term safety cases for the final deposition of radioactive wastes. The superior aim was the improved understanding of two-phase flow processes in a complex final repository system. The consideration of two-phase processes in modeling of final repository systems induces processes and effects that significantly affect the transport behavior of fluid and radionuclides. Two-phase processes include not only capillary pressures and relative permeabilities but also a basic competition of phases with respect to pore volume for storage and transport and density-driven vertical separation of phases. Basically seals have been shown to be essential for the system behavior because of their influence of the gas pressure dependent control function. The system behavior is also influences by the model geometry.

  17. Availability program: Phase I report

    International Nuclear Information System (INIS)

    Thomson, S.L.; Dabiri, A.; Keeton, D.C.; Riemer, B.W.; Waganer, L.M.

    1985-05-01

    An Availability Working Group was formed within the Office of Fusion Energy in March 1984 to consider the establishment of an availability program for magnetic fusion. The scope of this program is defined to include the development of (1) a comprehensive data base, (2) empirical correlations, and (3) analytical methods for application to fusion facilities and devices. The long-term goal of the availability program is to develop a validated, integrated methodology that will provide (1) projections of plant availability and (2) input to design decisions on maintainability and system reliability requirements. The Phase I study group was commissioned to assess the status of work in progress that is relevant to the availability program. The scope of Phase I included surveys of existing data and data collection programs at operating fusion research facilities, the assessment of existing computer models to calculate system availability, and the review of methods to predict and correlate data on component failure and maintenance. The results of these investigations are reported to the Availability Working Group in this document

  18. Estimation of Direct Melanoma-related Costs by Disease Stage and by Phase of Diagnosis and Treatment According to Clinical Guidelines

    Directory of Open Access Journals (Sweden)

    Alessandra Buja

    2017-11-01

    Full Text Available Cutaneous melanoma is a major concern in terms of healthcare systems and economics. The aim of this study was to estimate the direct costs of melanoma by disease stage, phase of diagnosis, and treatment according to the pre-set clinical guidelines drafted by the AIOM (Italian Medical Oncological Association. Based on the AIOM guidelines for malignant cutaneous melanoma, a highly detailed decision-making model was developed describing the patient’s pathway from diagnosis through the subsequent phases of disease staging, surgical and medical treatment, and follow-up. The model associates each phase potentially involving medical procedures with a likelihood measure and a cost, thus enabling an estimation of the expected costs by disease stage and clinical phase of melanoma diagnosis and treatment according to the clinical guidelines. The mean per-patient cost of the whole melanoma pathway (including one year of follow-up ranged from €149 for stage 0 disease to €66,950 for stage IV disease. The costs relating to each phase of the disease’s diagnosis and treatment depended on disease stage. It is essential to calculate the direct costs of managing malignant cutaneous melanoma according to clinical guidelines in order to estimate the economic burden of this disease and to enable policy-makers to allocate appropriate resources.

  19. Bioelectrical impedance phase angle in clinical practice: implications for prognosis in stage IIIB and IV non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Grutsch James F

    2009-01-01

    Full Text Available Abstract Background A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient outcomes. Bioelectrical impedance analysis (BIA is an easy-to-use and non-invasive technique to evaluate changes in body composition and nutritional status. We investigated the prognostic role of BIA-derived phase angle in advanced non-small cell lung cancer (NSCLC. Methods A case series of 165 stages IIIB and IV NSCLC patients treated at our center. The Kaplan Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle, independent of stage at diagnosis and prior treatment history. Results 93 were males and 72 females. 61 had stage IIIB disease at diagnosis while 104 had stage IV. The median phase angle was 5.3 degrees (range = 2.9 – 8. Patients with phase angle 5.3 had 12.4 months (95% CI: 10.5 to 18.7; n = 84; (p = 0.02. After adjusting for age, stage at diagnosis and prior treatment history we found that every one degree increase in phase angle was associated with a relative risk of 0.79 (95% CI: 0.64 to 0.97, P = 0.02. Conclusion We found BIA-derived phase angle to be an independent prognostic indicator in patients with stage IIIB and IV NSCLC. Nutritional interventions targeted at improving phase angle could potentially lead to an improved survival in patients with advanced NSCLC.

  20. Surgery or radiation therapy for Stage I and IIA carcinoma of the cervix

    International Nuclear Information System (INIS)

    Brady, L.W.

    1979-01-01

    The choice of treatment in carcinoma of the cervix is best decided after careful individual appraisal has been carried out. For best results, a long-term view must be agreed upon initially and careful followup by the same team is obligatory. At present, surgery, radiation therapy, and a combination of these two modalities have been employed successfully to manage carcinoma of the cervix. To a great extent, the facilities, the experience, and the interest of the personnel involved influence the type of therapy that will be employed. Generally speaking, the choice of treatment is determined primarily by the stage of the disease process. Radical surgery in the management of patients with Stage I and Stage II-A carcinoma of the cervix must be planned to include within the en bloc dissection the uterus, tubes, ovaries, and regional lymph node drainage from those organs. Therefore, a radical lymphadnectomy is an integral and important part of the overall management program when radical surgery is performed. In most institutions, radiation therapy is used most frequently to treat carcinoma of the cervix in Stages I and II-A. The data from various institutions indicate significant survival potential from radiation therapy treatment programs that are appropriately devised. In Stages I and II-A the complications are minimal in character (primarily proctitis and cystitis); generally, they involve a potential incidence of about six percent

  1. Two-Stage n-PSK Partitioning Carrier Phase Recovery Scheme for Circular mQAM Coherent Optical Systems

    DEFF Research Database (Denmark)

    Rodrigo Navarro, Jaime; Kakkar, Aditya; Pang, Xiaodan

    2016-01-01

    (ΔνTs) tolerance is achieved compared to the single-stage n-PSK partitioning scheme. Superior performance in the ΔνTs tolerance compared to the blind phase search algorithm is also reported. The relative improvements with respect to other CPR schemes are also validated experimentally for a 28-Gbaud C......A novel two-stage n-PSK partitioning carrier phase recovery (CPR) scheme for circular multilevel quadrature amplitude modulation (C-mQAM) constellations is presented. The first stage of the algorithm provides an initial rough estimation of the received constellation, which is utilized in the second...... stage for CPR. The performance of the proposed algorithm is studied through extensive simulations at the forward error correction bit error rate targets of 3.8 × 10−3 and 1 × 10−2 and is compared with different CPR algorithms. A significant improvement in the combined linewidth symbol duration product...

  2. Stage I/II endometrial carcinomas: preoperative radiotherapy: results

    International Nuclear Information System (INIS)

    Maingon, P.; Belichard, C.; Horiot, J.C.; Barillot, I.; Fraisse, J.; Collin, F.

    1996-01-01

    The AIM of this retrospective study is to analyse the indications and the results of treatment of endometrial carcinomas by preoperative radiotherapy. MATERIAL: From 1976 to 1995, 183 patients FIGO stage I or II were treated by preoperative radiotherapy consisting in 95 cases of external radiotherapy (XRT) and brachytherapy (BT) followed by surgery (S) and, in 88 cases of BT alone before surgery, XRT was indicated in cases of grade 2 or 3 and/or cervical involvement. METHODS: XRT was delivered with a 4-fields technique to 40 Gy in 20 fractions with a medial shielding at 30 Gy. BT was done with low dose rate Cs137 and Fletcher-Suit-Delclos applicators with two intra-uterine tubes and vaginal ovoieds. Complications were scored using the French-Italian syllabus. RESULTS: Five-year actuarial survival rates per stage are: Ia=91%, Ib=83%, II=71%, and per grade: G1=80%, G2=79%, G3=90%. Failures were pelvic in 5/183 (2.7%), vaginal in 4 cases (2%) and nodal in 2 cases (1%). Twelve patients developed metastases (6.5%). Complications were analysed during the radiotherapy, after the surgery and with unlimited follow-up. After BT/S, 12 grade 1, 1 grade 2 and 1 grade 3 complications were observed. In the group of patients treated by RT/BT/S, 22 grade 1, 11 grade 2, 4 grade 3 occurred. There is no statistical correlation between complications and parameters of treatment (XRT, hwt, HWT, reference dose to the bladder and rectum, dose rate of brachytherapy). SUMMARY: Preoperative irradiation is an effective and safe treatment of high risk stage I/II endometrial carcinomas. Results seem independent of the pathology grade

  3. Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) – Pilot trial of a phase I/II study: study protocol

    International Nuclear Information System (INIS)

    Rochet, Nathalie; Jensen, Alexandra D; Sterzing, Florian; Munter, Marc W; Eichbaum, Michael H; Schneeweiss, Andreas; Sohn, Christof; Debus, Juergen; Harms, Wolfgang

    2007-01-01

    The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy. More than 60% of patients will develop recurrent disease, principally intraperitoneal, and die within 5 years. The use of whole abdominal irradiation (WAI) as consolidation therapy would appear to be a logical strategy given its ability to sterilize small tumour volumes. Despite the clinically proven efficacy of whole abdominal irradiation, the use of radiotherapy in ovarian cancer has profoundly decreased mainly due to high treatment-related toxicity. Modern intensity-modulated radiation therapy (IMRT) could allow to spare kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. The OVAR-IMRT-01 study is a single center pilot trial of a phase I/II study. Patients with advanced ovarian cancer stage FIGO III (R1 or R2< 1 cm) after surgical resection and platinum-based chemotherapy will be treated with whole abdomen irradiation as consolidation therapy using intensity modulated radiation therapy (IMRT) to a total dose of 30 Gy in 1.5 Gy fractions. A total of 8 patients will be included in this trial. For treatment planning bone marrow, kidneys, liver, spinal cord, vertebral bodies and pelvic bones are defined as organs at risk. The planning target volume includes the entire peritoneal cavity plus pelvic and para-aortic node regions. The primary endpoint of the study is the evaluation of the feasibility of intensity-modulated WAI and the evaluation of the study protocol. Secondary endpoint is evaluation of the toxicity of intensity modulated WAI before continuing with the phase I/II study. The aim is to explore the potential of IMRT as a new method for WAI to decrease the dose to kidneys, liver, bone marrow while covering the peritoneal cavity with a homogenous dose, and to implement whole abdominal intensity-modulated radiotherapy into the adjuvant multimodal

  4. Multiple-Stage Structure Transformation of Organic-Inorganic Hybrid Perovskite CH3NH3PbI3

    Science.gov (United States)

    Chen, Qiong; Liu, Henan; Kim, Hui-Seon; Liu, Yucheng; Yang, Mengjin; Yue, Naili; Ren, Gang; Zhu, Kai; Liu, Shengzhong; Park, Nam-Gyu; Zhang, Yong

    2016-07-01

    By performing spatially resolved Raman and photoluminescence spectroscopy with varying excitation wavelength, density, and data acquisition parameters, we achieve a unified understanding towards the spectroscopy signatures of the organic-inorganic hybrid perovskite, transforming from the pristine state (CH3NH3PbI3 ) to the fully degraded state (i.e., PbI2 ) for samples with varying crystalline domain size from mesoscopic scale (approximately 100 nm) to macroscopic size (centimeters), synthesized by three different techniques. We show that the hybrid perovskite exhibits multiple stages of structure transformation occurring either spontaneously or under light illumination, with exceptionally high sensitivity to the illumination conditions (e.g., power, illumination time, and interruption pattern). We highlight four transformation stages (stages I-IV, with stage I being the pristine state) along either the spontaneous or photoinduced degradation path exhibiting distinctly different Raman spectroscopy features at each stage, and point out that previously reported Raman spectra in the literature reflect highly degraded structures of either stage III or stage IV. Additional characteristic optical features of partially degraded materials under the joint action of spontaneous and photodegradation are also given. This study offers reliable benchmark results for understanding the intrinsic material properties and structure transformation of this unique category of hybrid materials, and the findings are pertinently important to a wide range of potential applications where the hybrid material is expected to function in greatly different environment and light-matter interaction conditions.

  5. The Phase-I Trigger Readout Electronics Upgrade of the ATLAS Liquid Argon Calorimeters

    CERN Document Server

    Enari, Yuji; The ATLAS collaboration

    2018-01-01

    Electronics developments are pursued for the trigger readout of the ATLAS Liquid-Argon Calorimeter towards the Phase-I upgrade scheduled in the LHC shut-down period of 2019-2020. The LAr Trigger Digitizer system will digitize 34000 channels at a 40 MHz sampling with 12 bit precision after the bipolar shaper at the front-end system, and transmit to the LAr Digital Processing system in the back-end to extract the transverse energies. Results of ASIC developments including QA and radiation hardness evaluations, performances of the final prototypes and results of the system integration tests will presented along with the overall system design.

  6. Long-term results of definitive radiotherapy for stage I esophageal cancer

    International Nuclear Information System (INIS)

    Sai, Heitetsu; Mitsumori, Michihide; Araki, Norio; Mizowaki, Takashi; Nagata, Yasushi; Nishimura, Yasumasa; Hiraoka, Masahiro

    2005-01-01

    Purpose: To analyze retrospectively the long-term results of external beam radiotherapy (RT) with or without intraluminal brachytherapy (ILBT) for patients with Stage I esophageal cancer. Methods and Materials: A total of 34 patients with esophageal squamous cell carcinoma, clinically diagnosed as having Stage I disease, were treated with definitive RT, with or without ILBT. The median age was 69 years. Seven patients were treated with external beam RT alone (median, 64 Gy), and 27 were treated with external beam RT (median, 52 Gy) plus ILBT (8-12 Gy in two to three fractions). Results: The 5-year overall survival, local relapse-free survival, and cause-specific survival rate was 58.9%, 68.4%, and 80.0%, respectively, with a median follow-up of 61 months. Of 9 patients with local recurrence after initial therapy, 7 were successfully treated, and the 5-year cumulative rate of esophagectomy was 19.6%. The 2-year local relapse-free rate for patients with and without ILBT was 79.1% and 53.6%, respectively. Conclusion: Although local recurrence was frequent within 2 years, the disease-specific survival rate was high owing to effective salvage therapy. Definitive RT is a reasonable treatment option for highly comorbid and elderly patients with Stage I esophageal cancer. The role of ILBT needs to be clarified

  7. Final report on the surface-based investigation (phase 1) at the Mizunami Underground Laboratory project

    International Nuclear Information System (INIS)

    Saegusa, Hiromitsu; Seno, Yasuhiro; Nakama, Shigeo; Tsuruta, Tadahiko; Amano, Kenji; Takeuchi, Ryuji; Matsuoka, Toshiyuki; Onoe, Hironori; Mizuno, Takashi; Ohyama, Takuya; Hama, Katsuhiro; Sato, Toshinori; Kuji, Masayoshi; Kuroda, Hidetaka; Semba, Takeshi; Uchida, Masahiro; Sugihara, Kozo; Sakamaki, Masanori; Iwatsuki, Teruki

    2007-03-01

    The Mizunami Underground Laboratory (MIU) Project is a comprehensive research project investigating the deep underground environment within crystalline rock being conducted by Japan Atomic Energy Agency at Mizunami City in Gifu Prefecture, central Japan and its role is defined in 'Framework for Nuclear Energy Policy' by Japan Atomic Energy Commission. The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering for deep underground application. During Phase I, the overall project goals were supported by Phase I goals. For the overall project goals 1), the Phase I goals were set to construct models of the geological environment from all surface-based investigation results that describe the geological environment prior to excavation and predict excavation response. For the overall project goals 2), the Phase I goals were set to formulate detailed design concepts and a construction plan for the underground facilities. This report summarizes the Phase I investigation which was completed in March 2005. The authors believe this report will make an important milestone, since this report clarifies how the Phase I goals are achieved and evaluate the future issues thereby direct the research which will be conducted during Phase II. With regard to the overall project goals 1), 'To establish techniques for investigation, analysis and assessment of the deep geological environment,' a step-wise investigation was conducted by iterating investigation, interpretation, and assessment, thereby understanding of geologic environment was progressively and effectively improved with progress of investigation. An optimal procedure from

  8. SPIRIT advance care planning intervention in early stage dementias: An NIH stage I behavioral intervention development trial.

    Science.gov (United States)

    Song, Mi-Kyung; Ward, Sandra E; Hepburn, Kenneth; Paul, Sudeshna; Shah, Raj C; Morhardt, Darby J

    2018-06-02

    People in the early stages of Alzheimer's disease and related dementias (ADRD) are encouraged to engage in advance care planning (ACP) while they are still competent to appoint a surrogate decision maker and meaningfully participate in ACP discussions with the surrogate. In this NIH Stage I behavioral intervention development trial, we will adapt and test an efficacious ACP intervention, SPIRIT (Sharing Patient's Illness Representation to Increase Trust), with people with mild dementia and their surrogates to promote open, honest discussions while such discussions about end-of-life care are possible. We will first adapt SPIRIT (in person) to target people with mild dementia and their surrogates through a process of modification-pretesting-refinement using stakeholders (persons with mild dementia, family caregivers, and clinicians) and experts, including adapting the delivery mode to interactive web-based videoconference format (SPIRIT-remote). Then in a 3-group RCT with 120 patient-surrogate dyads, we will evaluate the feasibility and acceptability of SPIRIT in-person and SPIRIT remote, and preliminary efficacy of SPIRIT compared to usual care on preparedness outcomes for end-of-life decision making (dyad congruence on goals of care, patient decisional conflict, and surrogate decision-making confidence) shortly after the intervention. This Stage I research of SPIRIT will generate valuable insights regarding how to improve ACP for people with mild dementia who will progress to an advanced stage of the disease in the foreseeable future. ClinicalTrials.gov NCT03311711, Registered 10/12/2017. Copyright © 2018. Published by Elsevier Inc.

  9. Recovery in stages I and II of thermal and fission neutron irradiated molybdenum

    International Nuclear Information System (INIS)

    Coltman, R.R. Jr.; Klabunde, C.E.; Redman, J.K.

    1975-01-01

    The influence of initial dose and irradiation doping upon the recovery of Mo was studied for the markedly different types of damage produced by thermal and fission neutrons. The features of the Stage I recovery commonly seen for several fcc metals can be identified, including a I/sub D/ peak at 40 0 K. The typical dose-dependent behavior of a I/sub E/ subpeak was observed at approximately 47 0 K, and evidence for free interstitial migration is further supported by irradiation doping results. Stage II shows a first-order peak at 120 0 K in which the population percentage increases with increasing initial dose in opposite fashion to fcc impurity detrapping peaks. (auth)

  10. OSAS Surgery and Postoperative Discomfort: Phase I Surgery versus Phase II Surgery

    Directory of Open Access Journals (Sweden)

    Giulio Gasparini

    2015-01-01

    Full Text Available Introduction. This study aims to investigate the reasons that discourage the patients affected by OSAS to undergo orthognathic surgery and compares the postoperative discomfort of phase I (soft tissue surgery and phase II (orthognathic surgery procedures for treatment of OSAS. Material and Methods. A pool of 46 patients affected by OSAS was divided into two groups: “surgery patients” who accepted surgical treatments of their condition and “no surgery patients” who refused surgical procedures. The “surgery patients” group was further subdivided into two arms: patients who accepted phase I procedures (IP and those who accepted phase II (IIP. To better understand the motivations behind the refusal of II phase procedures, we asked the patients belonging to both the IP group and “no surgery” group to indicate the main reason that influenced their decision to avoid II phase procedures. We also monitored and compared five parameters of postoperative discomfort: pain, painkiller assumption, length of hospitalization, foreign body sensation, and diet assumption following IP and IIP procedures. Results. The main reason to avoid IIP procedures was the concern of a more severe postoperative discomfort. Comparison of the postoperative discomfort following IP versus IIP procedures showed that the former scored worse in 4 out of 5 parameters analyzed. Conclusion. IIP procedures produce less postoperative discomfort. IIP procedures, namely, orthognathic surgery, should be the first choice intervention in patients affected by OSAS and dentoskeletal malformation.

  11. Is mediastinal irradiation necessary for stage I testicular seminoma

    International Nuclear Information System (INIS)

    Jose, B.; Perkins, L.P.; Kays, H.; Chu, A.M.; Sharma, S.C.

    1984-01-01

    This study is a review of 39 patients with testicular seminoma, Stage I, treated at the Department of Radiation Oncology, James Graham Brown Cancer Center from 1959 to 1978. The age of the patients ranged from 16 to 70 years with a median of 37. Thirty-two (82%) patients presented with swelling or mass in the testis, four patients with pain, and three patients had seminoma diagnosed incidentally. Twenty (51%) patients had the tumor on the right side and 19 (49%) patients had the tumor on the left side. All patients received irradiation to the ipsilateral inguinal, iliac, and bilateral para-aortic nodes with ''hockey stick'' type fields. The majority of the patients received a midplane dose of 3,200 to 3,600 rad in 3-4 weeks time. None of the patients received prophylactic irradiation to the mediastinum and supraclavicular region. The 5-year actuarial survival rate is 96%. There is no additional benefit in giving prophylactic irradiation to the mediastinum and supraclavicular regions in Stage I testicular seminoma. A brief review of the literature regarding the role of prophylactic irradiation in this group of patients is done

  12. SBIR Phase I final Report

    Energy Technology Data Exchange (ETDEWEB)

    Stephen Grot

    2009-07-07

    The approach that we propose here in this SBIR proposal is a modified water electrolysis cell. In conventional water electrolysis the H2O is split into electrons, protons, and oxygen gas at the anode electrode. The electrons travel through an external power source and the protons travel through an electrolyte membrane to the cathode where they recombine to form hydrogen gas. The power source requires a minimum of 1.23 V to overcome the potential difference of the electrodes for the splitting of water. In contrast in our approach proposed here, instead of splitting water we are using acetate in wastewater and bacteria to oxidize the acetate into electrons and protons at the anode surface. The microbes release the electrons to the anode and the resulting protons move to the cathode electrode through the proton exchange membrane as described above and recombine to form hydrogen gas. The advantage here is that the required potential is now on the order of 0.25 to 0.8 V, and a considerable savings in electricity is realized to produce the same amount of hydrogen while at the same time removing organic matter from wastewater streams. Significant improvements in current density needs to be made in order for this type of technology to be economically viable

  13. Final Technical Report Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Macek, Robert J

    2012-01-27

    Low energy electrons (often referred to as "electron clouds") in the beam chambers of high intensity accelerators and storage rings can limit their performance. They can limit intensity by causing instabilities, unacceptable pressure increases or increases in beam size. Thus, reliable simulations of electron cloud generation in the Los Alamos high intensity Proton Storage Ring (PSR) and similar machines would be a most valuable tool for improving our understanding of its origin, the parameters that affect it and how it might be controlled. Such tools would provide cost-effective methods for designing mitigation measures and evaluating them before going to the expense of fabrication and experimental testing in an operating accelerator facility. In this project we have developed and tested several significant improvements to a widely used electron cloud simulation code, POSINST. In our version, LANLPOSINST V6, we have add several important features including the capability to model a multi-element section of the ring consisting of two quadrupole magnets with 3-dimensional magnetic fields, dipole magnet end fields, several drift spaces and various electron cloud diagnostics. Improvements were also added to the modeling of the initial primary or seed electrons from proton beam losses. One important conclusion from benchmarking these improvements was the need to include seed electrons produced from secondary particles resulting from the primary proton beam losses.

  14. Hyperfractionated radiotherapy alone for clinical stage I nonsmall cell lung cancer

    International Nuclear Information System (INIS)

    Jeremic, Branislav; Shibamoto, Yuta; Acimovic, Ljubisa; Milisavljevic, Slobodan

    1997-01-01

    Purpose: Among patients with Stage I nonsmall cell lung cancer (NSCLC), those treated with conventional radiotherapy show poorer prognosis than those treated by surgery. To improve the prognosis of such patients, we have used hyperfractionated radiation therapy. Methods and Materials: Between 1988 and 1993, 49 patients were treated with hyperfractionated radiotherapy with 1.2 Gy twice daily to a total dose of 69.6 Gy. All patients were technically operable, but 29 had medical problems and 20 refused surgery. The median age and Karnofsky Performance Status was 63 years and 90, respectively. No patient received chemotherapy or immunotherapy. Prophylactic mediastinal irradiation was not given. Results: The median survival time was 33 months, and the 5-year survival rate was 30%. The rate at 5 years for freedom from each of relapse, local recurrence, mediastinal lymphnode metastasis, and distant metastasis was 41%, 55%, 89%, and 75%, respectively. Univariate analysis revealed that higher Karnofsky Performance Status score, absence of weight loss before treatment, and T1 stage were associated with better survival, although the T stage became insignificant on multivariate analysis. There were two Grade 3 acute toxicities and three Grade 3 late toxicities, but there was no Grade 4-5 toxicity. Conclusion: The results of this study compare favorably with those of most previous studies employing conventional fractionation. Further studies on hyperfractionation seem to be warranted for Stage I NSCLC

  15. The Final Stage of Gravitationally Collapsed Thick Matter Layers

    Directory of Open Access Journals (Sweden)

    Piero Nicolini

    2013-01-01

    Full Text Available In the presence of a minimal length, physical objects cannot collapse to an infinite density, singular, matter point. In this paper, we consider the possible final stage of the gravitational collapse of “thick” matter layers. The energy momentum tensor we choose to model these shell-like objects is a proper modification of the source for “noncommutative geometry inspired,” regular black holes. By using higher momenta of Gaussian distribution to localize matter at finite distance from the origin, we obtain new solutions of the Einstein equation which smoothly interpolates between Minkowski’s geometry near the center of the shell and Schwarzschild’s spacetime far away from the matter layer. The metric is curvature singularity free. Black hole type solutions exist only for “heavy” shells; that is, M ≥Me, where Me is the mass of the extremal configuration. We determine the Hawking temperature and a modified area law taking into account the extended nature of the source.

  16. The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis

    DEFF Research Database (Denmark)

    Nicolini, Franck E; Ibrahim, Amr R; Soverini, Simona

    2013-01-01

    The BCR-ABL T315I mutation confers resistance to currently licensed tyrosine kinase inhibitors in chronic myelogenous leukemia. However, the impact of this mutation on survival in early stages of disease, in chronic phase, has never been detailed. Using matched pair analysis, a cohort of 64...... patients with chronic phase chronic myelogenous leukemia harboring a T315I mutation and resistant to imatinib mesylate was compared to a similar cohort of 53 chronic phase patients resistant to imatinib, but with no detectable T315I mutation, in the pre-ponatinib era. These patients were matched according...... to age at diagnosis, interval between disease diagnosis and start of imatinib treatment, and duration of imatinib therapy. Kaplan-Meier survival analyses demonstrated the significant negative impact of the presence of the T315I mutation on overall survival (since imatinib-resistance: 48.4 months for T315...

  17. Breast cancer relapse stage I and II

    International Nuclear Information System (INIS)

    Perez Braojos, Ines; Diaz Gestoso, Yadira; Franco Odio, Sonia; Samuel Gonzalez, Victor

    2009-01-01

    Breast cancer has always been the most common malignancy in women and is the leading cause of death in women, study relapses Stages I and II therapeutic guidelines applied in the service Mastology the 1985 - 1989, was our first objective, the database used was Clinical history, which gave us all the material necessary, treatments were: In tumors up to 3 cm node-conserving surgery plus treatment N0 with ionizing radiation on the breast tangential C0G0 in tumors greater than 3 cm or less with N1 was modified radical mastectomy according to node status for the study of the part and the receiver adjuvant treatment conducted. (Author)

  18. The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role In the Development of Liver Stage Malarial Parasites

    Science.gov (United States)

    Yu, Min; Santha Kumar, T. R.; Nkrumah, Louis J.; Coppi, Alida; Retzlaff, Silke; Li, Celeste D.; Kelly, Brendan J.; Moura, Pedro A.; Lakshmanan, Viswanathan; Freundlich, Joel S.; Valderramos, Juan-Carlos; Vilcheze, Catherine; Siedner, Mark; Tsai, Jennifer H.-C.; Falkard, Brie; Sidhu, Amar bir Singh; Purcell, Lisa A.; Gratraud, Paul; Kremer, Laurent; Waters, Andy P.; Schiehser, Guy; Jacobus, David P.; Janse, Chris J.; Ager, Arba; Jacobs, William R.; Sacchettini, James C.; Heussler, Volker; Sinnis, Photini; Fidock, David A.

    2008-01-01

    SUMMARY Fatty acid biosynthesis has been viewed as an important biological function of and therapeutic target for Plasmodium falciparum asexual blood stage infection. This apicoplast-resident type II pathway, distinct from the mammalian type I process, includes FabI. Here, we report synthetic chemistry and transfection studies concluding that Plasmodium FabI is not the target of the antimalarial activity of the bacterial FabI inhibitor triclosan. Disruption of fabI in P. falciparum or the rodent parasite P. berghei does not impede blood stage growth. In contrast, mosquito-derived fabI-deficient P. berghei sporozoites are markedly less infective for mice and typically fail to complete liver stage development in vitro. This is characterized by an inability to form intra-hepatic merosomes that normally initiate blood stage infections. These data illuminate key differences between liver and blood stage parasites in their requirements for host versus de novo synthesized fatty acids, and create new prospects for stage-specific antimalarial interventions. PMID:19064257

  19. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

    Science.gov (United States)

    Yu, Min; Kumar, T R Santha; Nkrumah, Louis J; Coppi, Alida; Retzlaff, Silke; Li, Celeste D; Kelly, Brendan J; Moura, Pedro A; Lakshmanan, Viswanathan; Freundlich, Joel S; Valderramos, Juan-Carlos; Vilcheze, Catherine; Siedner, Mark; Tsai, Jennifer H-C; Falkard, Brie; Sidhu, Amar Bir Singh; Purcell, Lisa A; Gratraud, Paul; Kremer, Laurent; Waters, Andrew P; Schiehser, Guy; Jacobus, David P; Janse, Chris J; Ager, Arba; Jacobs, William R; Sacchettini, James C; Heussler, Volker; Sinnis, Photini; Fidock, David A

    2008-12-11

    The fatty acid synthesis type II pathway has received considerable interest as a candidate therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast-resident pathway, distinct from the mammalian type I process, includes FabI. Here, we report synthetic chemistry and transfection studies concluding that Plasmodium FabI is not the target of the antimalarial activity of triclosan, an inhibitor of bacterial FabI. Disruption of fabI in P. falciparum or the rodent parasite P. berghei does not impede blood-stage growth. In contrast, mosquito-derived, FabI-deficient P. berghei sporozoites are markedly less infective for mice and typically fail to complete liver-stage development in vitro. This defect is characterized by an inability to form intrahepatic merosomes that normally initiate blood-stage infections. These data illuminate key differences between liver- and blood-stage parasites in their requirements for host versus de novo synthesized fatty acids, and create new prospects for stage-specific antimalarial interventions.

  20. TWRS phase I privatization site environmental baseline and characterization plan

    International Nuclear Information System (INIS)

    Shade, J.W.

    1997-01-01

    This document provides a plan to characterize and develop an environmental baseline for the TWRS Phase I Privatization Site before construction begins. A site evaluation study selected the former Grout Disposal Area of the Grout Treatment Facility in the 200 East Area as the TWRS Phase I Demonstration Site. The site is generally clean and has not been used for previous activities other than the GTF. A DQO process was used to develop a Sampling and Analysis Plan that would allow comparison of site conditions during operations and after Phase I ends to the presently existing conditions and provide data for the development of a preoperational monitoring plan

  1. Novel Versatile Intelligent Drug Delivery, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project will demonstrate and develop a novel micro-pump capable of controlled and selective chemical transport. Phase I will create, characterize, and...

  2. SELENE - Self-Forming Extensible Lunar EVA Network, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall objective of this research effort (Phase I and Phase II) by Scientific Systems Company, Inc. and BBN Technologies is to develop the SELENE network --...

  3. Impact of SO2 emissions cap on Phase I compliance decisions

    International Nuclear Information System (INIS)

    Bissell, P.E.; Fink, C.E.; Koch, B.J.; Chomka, P.A.

    1990-01-01

    The SO 2 emissions cap provisions of impending clean air legislation will dramatically affect Phase I and Phase II compliance decisions by electric utilities. Technology-based SO 2 reduction alternatives could become the keystone of most compliance strategies as utilities attempt to achieve lower and lower SO 2 emission rates. Compliance with the Phase II emissions cap will require technological solutions for many utilities which must meet system-wide SO 2 emission rates well below those achievable with low-sulfur eastern coals and, in many instances, western coals. The emissions cap provision, however, will also induce more scrubbing during the Phase I compliance period. The power generation dispatch capability of a hypothetical utility system was simulated to study the impacts of an SO 2 emission cap on compliance strategies in Phase I. The effects of the cap were quantified for generation costs, total SO 2 emissions, and effective emission rates. The results show that achieving compliance by installing state-of-the-art high SO 2 removal scrubbers becomes increasingly attractive as utilities become constrained under the SO 2 cap, even in Phase I

  4. Hybrid Propulsion Technology for Robotic Science Missions, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — C3 Propulsion's Hybrid Propulsion Technology will be applied to a NASA selected Sample Return Mission. Phase I will demonstrate Proof-of-Principle and Phase II will...

  5. Shape Memory Alloy Adaptive Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort will demonstrate and scale up an innovative manufacturing process that yields aerospace grade shape memory alloy (SMA) solids and periodic...

  6. Uncertainty Quantification in Aerodynamics Simulations, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the proposed work (Phases I and II) is to develop uncertainty quantification methodologies and software suitable for use in CFD simulations of...

  7. PWR steam generator chemical cleaning. Phase II. Final report

    International Nuclear Information System (INIS)

    1980-01-01

    Two techniques believed capable of chemically dissolving the corrosion products in the annuli between tubes and support plates were developed in laboratory work in Phase I of this project and were pilot tested in Indian Point Unit No. 1 steam generators. In Phase II, one of the techniques was shown to be inadequate on an actual sample taken from an Indian Point Unit No. 2 steam generator. The other technique was modified slightly, and it was demonstrated that the tube/support plate annulus could be chemically cleaned effectively

  8. Excisional biopsy, auxillary node dissection and definitive radiotherapy for Stages I and II breast cancer

    International Nuclear Information System (INIS)

    Danoff, B.F.; Pajak, T.F.; Solin, L.J.; Goodman, R.L.

    1985-01-01

    From 1977 to 1982, 189 patients with clinical Stage I and II breast cancer underwent excisional biopsy and auxillary node dissection followed by definitive radiotherapy at the University of Pennsylvania. One hundred and nine patients had T 1 lesions and 80 had T 2 lesions. Histologically negative nodes were found in 136 patients (72%) and histologically positive nodes in 53 patients. Median follow-up from the completion of radiotherapy was 26 months. The four year actuarial disease free survival is 82% for pathologic Stage I and 70% for pathologic Stage II. Cosmesis was judged to be good to excellent in 90% and fair in 9%. Complications included arm edema (7%), symptomatic pneumonitis (1%), rib fractures (1%), pericarditis (1%) and pleural effusion (1%). Primary radiotherapy for Stages I and II breast cancer produces a local-regional control rate of 95% and good to excellent cosmesis in 90% of the patients. While these results are preliminary, they compare favorably with other reported series

  9. Biomechanical and clinical factors related to stage I posterior tibial tendon dysfunction.

    Science.gov (United States)

    Rabbito, Melissa; Pohl, Michael B; Humble, Neil; Ferber, Reed

    2011-10-01

    Case control. To investigate differences in arch height, ankle muscle strength, and biomechanical factors in individuals with stage I posterior tibial tendon dysfunction (PTTD) in comparison to healthy individuals. PTTD is a progressive condition, so early recognition and treatment are essential to help delay or reverse the progression. However, no previous studies have investigated stage I PTTD, and no single study has measured static anatomical structure, muscle strength, and gait mechanics in this population. Twelve individuals with stage I PTTD and 12 healthy, age- and gender-matched control subjects, who were engaged in running-related activities, participated in this study. Measurements of arch height index, maximum voluntary ankle invertor muscle strength, and 3-dimensional rearfoot and medial longitudinal arch kinematics during walking were obtained. The runners with PTTD demonstrated significantly lower seated arch height index (P = .02) and greater (P = .03) and prolonged (P = .05) peak rearfoot eversion angle during gait, compared to the healthy runners. No differences were found in standing arch height index values (P = .28), arch rigidity index (P = .06), ankle invertor strength (P = .49), or peak medial longitudinal arch values (P = .49) between groups. The increased foot pronation is hypothesized to place greater strain on the posterior tibialis muscle, which may partially explain the progressive nature of this condition.

  10. Evidence of two-stage melting of Wigner solids

    Science.gov (United States)

    Knighton, Talbot; Wu, Zhe; Huang, Jian; Serafin, Alessandro; Xia, J. S.; Pfeiffer, L. N.; West, K. W.

    2018-02-01

    Ultralow carrier concentrations of two-dimensional holes down to p =1 ×109cm-2 are realized. Remarkable insulating states are found below a critical density of pc=4 ×109cm-2 or rs≈40 . Sensitive dc V-I measurement as a function of temperature and electric field reveals a two-stage phase transition supporting the melting of a Wigner solid as a two-stage first-order transition.

  11. TNX GeoSiphon Cell (TGSC-1) Phase II Single Cell Deployment/Demonstration Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Phifer, M.A.

    1999-04-15

    This Phase II final report documents the Phase II testing conducted from June 18, 1998 through November 13, 1998, and it focuses on the application of the siphon technology as a sub-component of the overall GeoSiphon Cell technology. [Q-TPL-T-00004

  12. Is CA-125 an additional help to radiologic findings for differentiation borderline ovarian tumor from stage I carcinoma?

    International Nuclear Information System (INIS)

    Lee, Eun Joo; Kim, See Hyung; Kim, Young Hwan; Lee, Hee Jung

    2011-01-01

    Background Borderline ovarian tumors (BOTs) are difficult to differentiate from stage I carcinoma using radiological findings. Little is known about the correlation between CA-125 levels and radiological findings for predicting BOTs or carcinoma. Purpose To assess the role of CA-125, in addition to that of radiological findings, in differentiating BOTs from stage I carcinoma. Material and Methods The study received institutional review board approval, with waiver of informed consent. We evaluated 100 patients (two groups: BOT, 58 patients; stage I carcinoma, 42 patients) using radiological findings, including location and size of each tumor, number and size of septations, papillary projections and vegetations, peritoneal implants, ascites, and preoperative CA-125 levels. The differences in CA-125 levels according to bilateral location, solid components, and thickness of septations between the two groups were evaluated using the McNemar test. Correlations of CA-125 level to size and number of septations were evaluated by the independent sample t test. Results No statistical correlation was found between CA-125 level and location, size, and number of septations between the two groups. Solid components within the tumors were similar in the two groups, but the CA-125 level was significantly higher in stage I carcinoma than in BOTs. The number of septations per tumor was similar in the two groups; thick septations were more frequent in stage I carcinoma than in BOTs, and a significantly higher titer of CA-125 was found in stage I carcinoma. Discriminant analysis of solid components and thickness of septations resulted in accurate diagnosis of 70.6% of the tumors (80.6% of BOTs and 69.7% of stage I carcinomas). Conclusion CA-125 levels for solid components and thickness of septations are lower in BOTs. These may be helpful in predicting the risk of carcinoma, even if BOTs cannot be conclusively differentiated from stage I carcinoma

  13. Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer

    International Nuclear Information System (INIS)

    Sekine, Ikuo

    2004-01-01

    To determine the recommended phase II dose of vinorelbine in combination with cisplatin and thoracic radiotherapy (TRT) in patients with unresectable stage III non-small cell lung cancer (NSCLC), 18 patients received cisplatin (80 mg/m 2 ) on day 1 and vinorelbine (20 mg/m 2 in level 1, and 25 mg/m 2 in level 2) on days 1 and 8 every 4 weeks for 4 cycles. TRT consisted of a single dose of 2 Gy once daily for 3 weeks followed by a rest of 4 days, and then the same TRT for 3 weeks to a total dose of 60 Gy. Fifteen (83%) patients received 60 Gy of TRT and 14 (78%) patients received 4 cycles of chemotherapy. Ten (77%) of 13 patients at level 1 and all 5 patients at level 2 developed grade 3-4 neutropenia. Four (31%) patients at level 1 and 3 (60%) patients at level 2 developed grade 3-4 infection. None developed ≥grade 3 esophagitis or lung toxicity. Dose-limiting toxicity was noted in 33% of the patients in level 1 and in 60% of the patients in level 2. The overall response rate (95% confidence interval) was 83% (59-96%) with 15 partial responses. The median survival time was 30.4 months, and the 1-year, 2-year, and 3-year survival rates were 72%, 61%, and 50%, respectively. In conclusion, the recommended dose is the level 1 dose, and this regimen is feasible and promising in patients with stage III NSCLC. (author)

  14. High-speed, low-damage grinding of advanced ceramics Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, J.A. [Eaton Corp., Willoughby Hills, OH (United States). Mfg. Technologies Center; Malkin, S. [Univ. of Massachusetts (United States)

    1995-03-01

    In manufacture of structural ceramic components, grinding costs can comprise up to 80% of the entire manufacturing cost. Most of these costs arise from the conventional multi-step grinding process with numerous grinding wheels and additional capital equipment, perishable dressing tools, and labor. In an attempt to reduce structural ceramic grinding costs, a feasibility investigation was undertaken to develop a single step, roughing-finishing process suitable for producing high-quality silicon nitride ceramic parts at high material removal rates at lower cost than traditional, multi-stage grinding. This feasibility study employed combined use of laboratory grinding tests, mathematical grinding models, and characterization of resultant material surface condition. More specifically, this Phase 1 final report provides a technical overview of High-Speed, Low-Damage (HSLD) ceramic grinding and the conditions necessary to achieve the small grain depths of cut necessary for low damage grinding while operating at relatively high material removal rates. Particular issues addressed include determining effects of wheel speed and material removal rate on resulting mode of material removal (ductile or brittle fracture), limiting grinding forces, calculation of approximate grinding zone temperatures developed during HSLD grinding, and developing the experimental systems necessary for determining HSLD grinding energy partition relationships. In addition, practical considerations for production utilization of the HSLD process are also discussed.

  15. Deep Ultraviolet Macroporous Silicon Filters, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I proposal describes a novel method to make deep and far UV optical filters from macroporous silicon. This type of filter consists of an array of...

  16. The phase transition and elastic and optical properties of polymorphs of CuI

    International Nuclear Information System (INIS)

    Zhu Jiajie; Pandey, Ravindra; Gu Mu

    2012-01-01

    The high-pressure polymorphs of CuI have attracted much attention due to the somewhat contradictory identification of their structures by means of x-ray diffraction measurements and theoretical calculations. In this paper, we report the results of a theoretical investigation of polymorphs of CuI including zinc-blende, rhombohedral, tetragonal, rocksalt and orthorhombic phases. We find that CuI follows the high-pressure transition path from the zinc-blende phase to the orthorhombic phase via the tetragonal phase, and the rhombohedral phase shows mechanical instability under high pressure. The bulk moduli are almost isotropic but the shear moduli show large anisotropy in these polymorphs. A relatively strong hybridization of I p and Cu d states appears to determine the electronic properties of the CuI polymorphs. The zinc-blende and tetragonal CuI are direct gap semiconductors and their optical properties are similar, whereas the orthorhombic CuI is metallic.

  17. Stage-I osteochondritis dissecans versus normal variants of ossification in the knee in children

    International Nuclear Information System (INIS)

    Gebarski, Kathleen; Hernandez, Ramiro J.

    2005-01-01

    Juvenile osteochondritis dissecans (OCD) has a better prognosis than the adult type. We postulated that the excellent prognosis of juvenile OCD could be explained, at least in part, by the erroneous diagnosis of some developmental variants of ossification as stage-I OCD. Knee MRIs of 38 children, ages 7.5-17.7 years (mean and median age 13 years), were retrospectively reviewed to look for features that might separate normal variants of ossification from stage-I OCD. These included age, gender, site, configuration of the lesion, residual cartilaginous model and presence of edema. Twenty-three patients (32 condyles) had ossification defects with intact articular cartilage suggestive of stage-I lesions. No stage-II lesions were seen in the posterior femoral condyles. Accessory ossification centers were seen in 11/16 posterior condyles and 3/16 central condyles. Spiculation of existing ossification was seen in 12/16 posterior condylar lesions and 1/16 central condyles. There was a predominance of accessory ossifications and spiculations in the patients with 10% or greater residual cartilaginous model. No edema signal greater than diaphyseal red-marrow signal was seen in the posterior condyles. Clinical follow-up ranged from 0.5 to 38 months, with clinical improvement in 22 out of 23 patients. Inclusion of normal variants in the stage-I OCD category might explain, in part, the marked difference in published outcome between the juvenile and adult forms of OCD. Ossification defects in the posterior femoral condyles with intact overlying articular cartilage, accessory ossification centers, spiculation, residual cartilaginous model, and lack of bone-marrow edema are features of developmental variants rather than OCD. (orig.)

  18. Technical report on LWR design decision methodology. Phase I

    International Nuclear Information System (INIS)

    1980-03-01

    Energy Incorporated (EI) was selected by Sandia Laboratories to develop and test on LWR design decision methodology. Contract Number 42-4229 provided funding for Phase I of this work. This technical report on LWR design decision methodology documents the activities performed under that contract. Phase I was a short-term effort to thoroughly review the curret LWR design decision process to assure complete understanding of current practices and to establish a well defined interface for development of initial quantitative design guidelines

  19. Compact Monitor for Airborne Carbon Dioxide Measurements, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Eltron Research we anticipate a TRL of 4 by the end of Phase I. By the end of the Phase II program, a prototype instrument will be built with ±0.1 ppm resolution in...

  20. Feasibility study on commercialized fast reactor cycle systems. Phase II final report

    International Nuclear Information System (INIS)

    Ieda, Yoshiaki; Uchikawa, Sadao; Okubo, Tsutomu; Ono, Kiyoshi; Kato, Atsushi; Kurisaka, Kenichi; Sakamoto, Yoshihiko; Sato, Kazujiro; Sato, Koji; Chikazawa, Yoshitaka; Nakai, Ryodai; Nakabayashi, Hiroki; Nakamura, Hirofumi; Namekawa, Takashi; Niwa, Hajime; Nomura, Kazunori; Hayashi, Hideyuki; Hayafune, Hiroki; Hirao, Kazunori; Mizuno, Tomoyasu; Muramatsu, Toshiharu; Ando, Masato; Ono, Katsumi; Ogata, Takanari; Kubo, Shigenobu; Kotake, Shoji; Sagayama, Yutaka; Takakuma, Katsuyuki; Tanaka, Toshihiko; Namba, Takashi; Fujii, Sumio; Muramatsu, Kazuyoshi

    2006-06-01

    A joint project team of Japan Atomic Energy Agency and the Japan Atomic Power Company (as the representative of the electric utilities) started the feasibility study on commercialized fast reactor cycle systems (F/S) in July 1999 in cooperation with Central Research Institute of Electric Power Industry and vendors. On the major premise of safety assurance, F/S aims to present an appropriate picture of commercialization of fast reactor (FR) cycle system which has economic competitiveness with light water reactor cycle systems and other electricity base load systems, and to establish FR cycle technologies for the future major energy supply. In the period from Japanese fiscal year (JFY) 1999 to 2000, the phase-I of F/S was carried out to screen our representative FR, reprocessing and fuel fabrication technologies. In the phase-II (JFY 2001-2005), the design study of FR cycle concepts, the development of significant technologies necessary for the feasibility evaluation, and the confirmation of key technical issues were performed to clarify the promising candidate concepts toward the commercialization. In this final phase-II report clarified the most promising concept, the R and D plan until around 2015, and the key issues for the commercialization. Based on the comprehensive evaluation in F/S, the combination of the sodium-cooled FR with MOX fuel core, the advanced-aqueous reprocessing process and the simplified-pelletizing fuel fabrication process was recommended as the mainline choice for the most promising concept. The concept exceeds in technical advancement, and the conformity to the development targets was higher compared with that of the others. Alternative technologies are prepared to be decrease the development risk of innovative technologies in the mainline choice. (author)

  1. Local Control and Survival Following Concomitant Chemoradiotherapy in Inoperable Stage I Non-Small-Cell Lung Cancer

    International Nuclear Information System (INIS)

    Campeau, Marie-Pierre; Herschtal, Alan; Wheeler, Greg; Mac Manus, Michael; Wirth, Andrew; Michael, Michael; Hogg, Annette; Drummond, Elizabeth; Ball, David

    2009-01-01

    Purpose: Concomitant chemoradiotherapy (CRT) increases survival rates compared with radical radiotherapy alone (RT) in Stage III non-small-cell lung cancer (NSCLC), as a result of improved local control. The effect of CRT on local control in Stage I NSCLC is less well documented. We retrospectively reviewed local control and survival following CRT or RT for inoperable Stage I NSCLC patients. Methods and materials: Eligible patients had histologically/cytologically proved inoperable Stage I NSCLC and had undergone complete staging investigations including an F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan. Radiotherapy was planned as (1) 60 Gy in 30 fractions over 6 weeks with or without concomitant chemotherapy or (2) 50-55 Gy in 20 fractions without chemotherapy. Results: Between 2000 and 2005, 73 patients met the eligibility criteria and were treated as follows: CRT (60 Gy)-39; RT (60 Gy)-23; RT (50-55 Gy)-11. The median follow-up time for all patients was 18 months (range, 1-81 months). Survival analysis was based on intent to treat. Local progression-free survival (PFS) at 2 years was 66% with CRT and 55% with RT. The 2-year distant PFS was 60% following CRT and 63% after RT. The 2-year PFS rates were 57% and 50%, respectively. The 2-year survival rate for patients treated with CRT was 57% and 33% in patients receiving RT. Conclusions: Despite the use of CRT and routine staging with FDG-PET, both local and distant recurrences remain important causes of treatment failure in patients with inoperable stage I NSCLC.

  2. Aerodynamic Analyses and Database Development for Ares I Vehicle First Stage Separation

    Science.gov (United States)

    Pamadi, Bandu N.; Pei, Jing; Pinier, Jeremy T.; Holland, Scott D.; Covell, Peter F.; Klopfer, Goetz, H.

    2012-01-01

    This paper presents the aerodynamic analysis and database development for the first stage separation of the Ares I A106 Crew Launch Vehicle configuration. Separate databases were created for the first stage and upper stage. Each database consists of three components: isolated or free-stream coefficients, power-off proximity increments, and power-on proximity increments. The power-on database consists of three parts, all plumes firing at nominal conditions, the one booster deceleration motor out condition, and the one ullage settling motor out condition. The isolated and power-off incremental databases were developed using wind tunnel test data. The power-on proximity increments were developed using CFD solutions.

  3. The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer

    Science.gov (United States)

    2018-03-02

    Invasive Breast Carcinoma; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7

  4. Development of improved processing and evaluation methods for high reliability structural ceramics for advanced heat engine applications, Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pujari, V.K.; Tracey, D.M.; Foley, M.R.; Paille, N.I.; Pelletier, P.J.; Sales, L.C.; Wilkens, C.A.; Yeckley, R.L. [Norton Co., Northboro, MA (United States)

    1993-08-01

    The program goals were to develop and demonstrate significant improvements in processing methods, process controls and non-destructive evaluation (NDE) which can be commercially implemented to produce high reliability silicon nitride components for advanced heat engine applications at temperatures to 1,370{degrees}C. The program focused on a Si{sub 3}N{sub 4}-4% Y{sub 2}O{sub 3} high temperature ceramic composition and hot-isostatic-pressing as the method of densification. Stage I had as major objectives: (1) comparing injection molding and colloidal consolidation process routes, and selecting one route for subsequent optimization, (2) comparing the performance of water milled and alcohol milled powder and selecting one on the basis of performance data, and (3) adapting several NDE methods to the needs of ceramic processing. The NDE methods considered were microfocus X-ray radiography, computed tomography, ultrasonics, NMR imaging, NMR spectroscopy, fluorescent liquid dye penetrant and X-ray diffraction residual stress analysis. The colloidal consolidation process route was selected and approved as the forming technique for the remainder of the program. The material produced by the final Stage II optimized process has been given the designation NCX 5102 silicon nitride. According to plan, a large number of specimens were produced and tested during Stage III to establish a statistically robust room temperature tensile strength database for this material. Highlights of the Stage III process demonstration and resultant database are included in the main text of the report, along with a synopsis of the NCX-5102 aqueous based colloidal process. The R and D accomplishments for Stage I are discussed in Appendices 1--4, while the tensile strength-fractography database for the Stage III NCX-5102 process demonstration is provided in Appendix 5. 4 refs., 108 figs., 23 tabs.

  5. Seeking informed consent to Phase I cancer clinical trials: identifying oncologists' communication strategies.

    Science.gov (United States)

    Brown, Richard; Bylund, Carma L; Siminoff, Laura A; Slovin, Susan F

    2011-04-01

    Phase I clinical trials are the gateway to effective new cancer treatments. Many physicians have difficulty when discussing Phase I clinical trials. Research demonstrates evidence of suboptimal communication. Little is known about communication strategies used by oncologists when recruiting patients for Phase I trials. We analyzed audio recorded Phase I consultations to identify oncologists' communication strategies. Subjects were consecutive cancer patients from six medical oncologists attending one of three outpatient clinics at a major Cancer Center in the United States. Sixteen patients signed informed consent for audio recording of their consultations in which a Phase I study was discussed. These were transcribed in full and analyzed to identify communication strategies. Six communication themes emerged from the analysis: (1) orienting, (2) educating patients, (3) describing uncertainty and prognosis, (4) persuading, (5) decision making, and (6) making a treatment recommendation. As expected, although there was some common ground between communication in Phase I and the Phase II and III settings, there were distinct differences. Oncologists used persuasive communication, made explicit recommendations, or implicitly expressed a treatment preference and were choice limiting. This highlights the complexity of discussing Phase I trials and the need to develop strategies to aid oncologists and patients in these difficult conversations. Patient centered communication that values patient preferences while preserving the oncologist's agenda can be a helpful approach to these discussions. Copyright © 2010 John Wiley & Sons, Ltd.

  6. Two-Stage n-PSK Partitioning Carrier Phase Recovery Scheme for Circular mQAM Coherent Optical Systems

    Directory of Open Access Journals (Sweden)

    Jaime Rodrigo Navarro

    2016-06-01

    Full Text Available A novel two-stage n-PSK partitioning carrier phase recovery (CPR scheme for circular multilevel quadrature amplitude modulation (C-mQAM constellations is presented. The first stage of the algorithm provides an initial rough estimation of the received constellation, which is utilized in the second stage for CPR. The performance of the proposed algorithm is studied through extensive simulations at the forward error correction bit error rate targets of 3.8 × 10−3 and 1 × 10−2 and is compared with different CPR algorithms. A significant improvement in the combined linewidth symbol duration product (ΔνTs tolerance is achieved compared to the single-stage n-PSK partitioning scheme. Superior performance in the ΔνTs tolerance compared to the blind phase search algorithm is also reported. The relative improvements with respect to other CPR schemes are also validated experimentally for a 28-Gbaud C-16QAM back-to-back transmission system. The computational complexity of the proposed CPR scheme is studied, and reduction factors of 24.5 | 30.1 and 59.1 | 63.3 are achieved for C-16QAM and C-64QAM, respectively, compared to single-stage BPS in the form of multipliers | adders.

  7. A systematic methodology review of phase I radiation dose escalation trials

    International Nuclear Information System (INIS)

    Pijls-Johannesma, Madelon; Mastrigt, Ghislaine van; Hahn, Steve M.; De Ruysscher, Dirk; Baumert, Brigitta G.; Lammering, Guido; Buijsen, Jeroen; Bentzen, Soren M.; Lievens, Yolande; Kramar, Andrew; Lambin, Philippe

    2010-01-01

    Background and purpose: The purpose of this review is to evaluate the methodology used in published phase I radiotherapy (RT) dose escalation trials. A specific emphasis was placed on the frequency of reporting late complications as endpoint. Materials and methods: We performed a systematic literature review using a predefined search strategy to identify all phase I trials reporting on external radiotherapy dose escalation in cancer patients. Results: Fifty-three trials (phase I: n = 36, phase I-II: n = 17) fulfilled the inclusion criteria. Of these, 20 used a modified Fibonacci design for the RT dose escalation, but 32 did not specify a design. Late toxicity was variously defined as >3 months (n = 43) or > 6 months (n = 3) after RT, or not defined (n = 7). In only nine studies the maximum tolerated dose (MTD) was related to late toxicity, while only half the studies reported the minimum follow-up period for dose escalation (n = 26). Conclusion: In phase I RT trials, late complications are often not taken into account and there is currently no consensus on the methodology used for radiation dose escalation studies. We therefore propose a decision-tree algorithm which depends on the endpoint selected and whether a validated early surrogate endpoint is available, in order to choose the most appropriate study design.

  8. Detection of perturbation phases and developmental stages in organisms from DNA microarray time series data.

    Directory of Open Access Journals (Sweden)

    Marianne Rooman

    Full Text Available Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profiles on the basis of a translation-invariant and scale-invariant distance measure corresponding to least-rectangle regression, it is shown that peaks in the average distance values are noticeable and are localized around specific time points. These points systematically coincide with the transition points between developmental phases or just follow the external perturbations. This approach can thus be used to identify automatically, from microarray time series alone, the presence of external perturbations or the succession of developmental stages in arbitrary cell systems. Moreover, our results show that there is a striking similarity between the gene expression responses to these a priori very different phenomena. In contrast, the cell cycle does not involve a perturbation-like phase, but rather continuous gene expression remodeling. Similar analyses were conducted using three other standard distance measures, showing that the one we introduced was superior. Based on these findings, we set up an adapted clustering method that uses this distance measure and classifies the genes on the basis of their expression profiles within each developmental stage or between perturbation phases.

  9. Seal Analysis for the Ares-I Upper Stage Fuel Tank Manhole Cover

    Science.gov (United States)

    Phillips, Dawn R.; Wingate, Robert J.

    2010-01-01

    Techniques for studying the performance of Naflex pressure-assisted seals in the Ares-I Upper Stage liquid hydrogen tank manhole cover seal joint are explored. To assess the feasibility of using the identical seal design for the Upper Stage as was used for the Space Shuttle External Tank manhole covers, a preliminary seal deflection analysis using the ABAQUS commercial finite element software is employed. The ABAQUS analyses are performed using three-dimensional symmetric wedge finite element models. This analysis technique is validated by first modeling a heritage External Tank liquid hydrogen tank manhole cover joint and correlating the results to heritage test data. Once the technique is validated, the Upper Stage configuration is modeled. The Upper Stage analyses are performed at 1.4 times the expected pressure to comply with the Constellation Program factor of safety requirement on joint separation. Results from the analyses performed with the External Tank and Upper Stage models demonstrate the effects of several modeling assumptions on the seal deflection. The analyses for Upper Stage show that the integrity of the seal is successfully maintained.

  10. ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment

    Science.gov (United States)

    2018-03-02

    Oral Cavity Neoplasm; Oropharyngeal Neoplasm; Stage I Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7

  11. Relationship between push phase and final race time in skeleton performance.

    Science.gov (United States)

    Zanoletti, Costanza; La Torre, Antonio; Merati, Giampiero; Rampinini, Ermanno; Impellizzeri, Franco M

    2006-08-01

    The aim of this study was to examine the relationship between push-time and final race time in skeleton participants during a series of major international competitions to determine the importance of the push phase in skeleton performance. Correlations were computed from the first and second heat split data measured during 24 men and 24 women skeleton competitions. Body mass, height, age, and years of experience of the first 30 men and women athletes of the skeleton, bobsleigh and luge 2003-2004 World Cup ranking were used for the comparison between sliding sports. Moderate but significant correlations (p push-time and final race time in men (r(mean) = 0.48) and women (r(mean) = 0.63). No correlations were found between changes in the individual push-time between the first and second heat with the corresponding changes in final race time. The bobsleigh sliders are heavier than the athletes of the other sliding disciplines. Luge athletes have more experience and are younger than bobsleigh and skeleton sliders. The results of this study suggest that a fast push phase is a prerequisite to success in competition and confirms that the selection of skeleton athletes based on the ability to accelerate to a maximum speed quickly could be valid. However, a good or improved push-time does not ensure a placement in the top finishing positions. On the basis of these results, we suggest that strength and power training is necessary to maintain a short push-time but additional physical training aimed to enhance the push phase might not reflect performance improvements. The recruitment of younger athletes and an increase of youthful competitive activity may be another effective way to reach international competitive results.

  12. Long-term follow-up of a phase I/II trial of dose escalating three-dimensional conformal thoracic radiation therapy with induction and concurrent carboplatin and paclitaxel in unresectable stage IIIA/B non-small cell lung cancer.

    Science.gov (United States)

    Stinchcombe, Thomas E; Lee, Carrie B; Moore, Dominic T; Rivera, M Patricia; Halle, Jan; Limentani, Steven; Rosenman, Julian G; Socinski, Mark A

    2008-11-01

    We conducted a modified phase I/II trial investigating the incorporation of three-dimensional conformal thoracic radiation therapy (TCRT) into the treatment paradigm of induction and concurrent carboplatin and paclitaxel in patients with unresectable stage IIIA/B non-small cell lung cancer. Patients received 2 cycles of induction carboplatin (area under the curve of 6) and paclitaxel (225 mg/m) on days 1, and 22. On day 43 concurrent TCRT and weekly x6 of carboplatin (area under the curve = 2) and paclitaxel (45 mg/m) was initiated. The TCRT dose was escalated from 60 to 74 Gy in 4 cohorts (60, 66, 70, and 74 Gy), and the 74 Gy cohort was expanded into a phase II trial. Sixty-two patients were enrolled; the median age 57 years (range, 36-82), 39 were male (63%), 61 (98%) had a performance status of 0 or 1, 28 (45%) had stage IIIA disease, 21 (34%) had >5% weight loss, and the median forced expiratory volume 1 = 2.10 liters (range, 1.02-3.75). With a median follow-up for survivors of approximately 9 years (range, 7-11 years) the median progression-free survival, time to tumor progression, and overall survival (OS) (with 95% confidence intervals) were 10 (8.5-17), 15 (9-50), and 25 months (18-37), respectively. The 5-year progression-free survival and OS rates were 21% (12-32%) and 27% (17-39%), respectively. The 10-year OS rate was 14% (7-25%). The long term survival rate compares favorably to other treatment approaches for stage III non-small cell lung cancer.

  13. Sentinel node biopsy for early-stage melanoma - Accuracy and morbidity in MSLT-I, an international multicenter trial

    NARCIS (Netherlands)

    Morton, DL; Cochran, AJ; Thompson, JF; Elashoff, R; Essner, R; Glass, EC; Mozzillo, N; Nieweg, OE; Roses, DF; Hoekstra, HJ; Karakousis, CP; Reintgen, DS; Coventry, BJ; Wang, HJ

    Objective:The objective of this study was to evaluate, in an international multicenter phase III trial, the accuracy, use, and morbidity of intraoperative lymphatic mapping and sentinel node biopsy (LM/SNB) for staging the regional nodal basin of patients with early-stage melanoma. Summary

  14. Improved Survival With Radiation Therapy in Stage I-II Primary Mediastinal B Cell Lymphoma: A Surveillance, Epidemiology, and End Results Database Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Matthew W., E-mail: matthew.jackson@ucdenver.edu [Department of Radiation Oncology, University of Colorado Cancer Center, Aurora, Colorado (United States); Rusthoven, Chad G.; Jones, Bernard L. [Department of Radiation Oncology, University of Colorado Cancer Center, Aurora, Colorado (United States); Kamdar, Manali [Department of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado (United States); Rabinovitch, Rachel [Department of Radiation Oncology, University of Colorado Cancer Center, Aurora, Colorado (United States)

    2016-01-01

    Background: Primary mediastinal B cell lymphoma (PMBCL) is an uncommon lymphoma for which trials are few with small patient numbers. The role of radiation therapy (RT) after standard immunochemotherapy for early-stage disease has never been studied prospectively. We used the Surveillance, Epidemiology, and End Results (SEER) database to evaluate PMBCL and the impact of RT on outcomes. Methods and Materials: We queried the SEER database for patients with stage I-II PMBCL diagnosed from 2001 to 2011. Retrievable data included age, gender, race (white/nonwhite), stage, extranodal disease, year of diagnosis, and use of RT as a component of definitive therapy. Kaplan-Meier overall survival (OS) estimates, univariate (UVA) log-rank and multivariate (MVA) Cox proportional hazards regression analyses were performed. Results: Two hundred fifty patients with stage I-II disease were identified, with a median follow-up time of 39 months (range, 3-125 months). The median age was 36 years (range, 18-89 years); 61% were female; 76% were white; 45% had stage I disease, 60% had extranodal disease, and 55% were given RT. The 5-year OS for the entire cohort was 86%. On UVA, OS was improved with RT (hazard ratio [HR] 0.446, P=.029) and decreased in association with nonwhite race (HR 2.70, P=.006). The 5-year OS was 79% (no RT) and 90% (RT). On MVA, white race and RT remained significantly associated with improved OS (P=.007 and .018, respectively). The use of RT decreased over time: 61% for the 67 patients whose disease was diagnosed from 2001 to 2005 and 53% in the 138 patients treated from 2006 to 2010. Conclusion: This retrospective population-based analysis is the largest PMBCL dataset to date and demonstrates a significant survival benefit associated with RT. Nearly half of patients treated in the United States do not receive RT, and its use appears to be declining. In the absence of phase 3 data, the use of RT should be strongly considered for its survival benefit in early-stage

  15. Safety and hemostatic efficacy of fibrin pad in partial nephrectomy: Results of an open-label Phase I and a randomized, standard-of-care-controlled Phase I/II study

    Directory of Open Access Journals (Sweden)

    Nativ Ofer

    2012-11-01

    Full Text Available Abstract Background Bleeding severity, anatomic location, tissue characteristics, and visibility are common challenges encountered while managing intraoperative bleeding, and conventional hemostatic measures (suture, ligature, and cautery may sometimes be ineffective or impractical. While topical absorbable hemostats (TAH are useful hemostatic adjuvants, each TAH has associated disadvantages. Methods We evaluated the safety and hemostatic efficacy of a new advanced biologic combination product―fibrin pad―to potentially address some gaps associated with TAHs. Fibrin pad was assessed as adjunctive hemostat in open partial nephrectomy in single-center, open-label, Phase I study (N = 10, and as primary hemostat in multicenter, single-blind, randomized, standard-of-care (SOC-controlled Phase I/II study (N = 7 in Israel. It was used to control mild-to-moderate bleeding in Phase I and also spurting arterial bleeding in Phase I/II study. Phase I study assessed safety and Phase I/II study, proportion of successes at 10 min following randomization, analyzed by Fisher exact tests at 5% significance level. Results Phase I (N = 10: All patients completed the study. Hemostasis was achieved within 3–4 min (average = 3.1 min of a single application in all patients. Fibrin pad was found to be safe for human use, with no product-related adverse events reported. Phase I/II (N = 7: Hemostatic success at 10 min (primary endpoint was achieved in 3/4 patients treated with fibrin pad versus 0/3 patients treated with SOC. No clinically significant change in laboratory or coagulation parameters was recorded, except a case of post-procedural hemorrhage with fibrin pad, which was considered serious and related to the fibrin pad treatment, and required re-operation. Although Data Safety Monitoring Board authorized trial continuation, the sponsor decided against proceeding toward an indication for primary treatment of severe arterial

  16. Værktøjskasse til Agil Stage-Gate®: Ny model for udviklingsprojekter i mellemstore virksomheder

    DEFF Research Database (Denmark)

    Vedsmand, Tomas; Edwards, Kasper; Hvidt, Nicoline

    Denne værktøjskasse er et tillæg for guiden Agil Stage-Gate: Ny model for udviklingsprojekter i mellemstore virksomheder. (http://dx.doi.org/10.11581/DTU:00000028)......Denne værktøjskasse er et tillæg for guiden Agil Stage-Gate: Ny model for udviklingsprojekter i mellemstore virksomheder. (http://dx.doi.org/10.11581/DTU:00000028)...

  17. Waste Management Effluent Treatment Facility: Phase I. CAC basic data

    International Nuclear Information System (INIS)

    Gemar, D.W.; O'Leary, C.D.

    1984-01-01

    In order to expedite design and construction of the Waste Management Effluent Treatment Facility (WMETF), the project has been divided into two phases. Phase I consists of four storage basins and the associated transfer lines, diversion boxes, and control rooms. The design data pertaining to Phase I of the WMETF project are presented together with general background information and objectives for both phases. The project will provide means to store and decontaminate wastewater streams that are currently discharged to the seepage basins in F Area and H Area. This currently includes both routine process flows sent directly to the seepage basins and diversions of contaminated cooling water or storm water runoff that are stored in the retention basins before being pumped to the seepage basins

  18. Phase separation process in FeCr alloys studied by neutron small angle scattering

    International Nuclear Information System (INIS)

    Furusaka, Michihiro; Ishikawa, Yoshikazu; Yamaguchi, Sadae; Fujino, Yutaka.

    1986-01-01

    The very early stage as well as late stage of phase separation process in FeCr alloys (Fe-20, 30, 40, 60 at%Cr) have been studied by pulsed cold neutron small angle scattering instrument (SAN). At the early stage, scattering intensity I(q) obeys q -2 dependence at the high q side of the scattering function. The results are in accord with the theory of Langer et al. which takes into account nonlinear and thermal fluctuations effects. At the late stage where I(q) shows q -4 dependence, a dynamical scaling law holds, while it is not the case for the earlier stage. Phase diagram of FeCr system is also determined by critical scattering measurements. (author)

  19. COMPASS Final Report: Enceladus Solar Electric Propulsion Stage

    Science.gov (United States)

    Oleson, Steven R.; McGuire, Melissa L.

    2011-01-01

    The results of the NASA Glenn Research Center (GRC) COllaborative Modeling and Parametric Assessment of Space Systems (COMPASS) internal Solar Electric Propulsion (SEP) stage design are documented in this report (Figure 1.1). The SEP Stage was designed to deliver a science probe to Saturn (the probe design was performed separately by the NASA Goddard Space Flight Center s (GSFC) Integrated Mission Design Center (IMDC)). The SEP Stage delivers the 2444 kg probe on a Saturn trajectory with a hyperbolic arrival velocity of 5.4 km/s. The design carried 30 percent mass, 10 percent power, and 6 percent propellant margins. The SEP Stage relies on the probe for substantial guidance, navigation and control (GN&C), command and data handling (C&DH), and Communications functions. The stage is configured to carry the probe and to minimize the packaging interference between the probe and the stage. The propulsion system consisted of a 1+1 (one active, one spare) configuration of gimbaled 7 kW NASA Evolutionary Xenon Thruster (NEXT) ion propulsion thrusters with a throughput of 309 kg Xe propellant. Two 9350 W GaAs triple junction (at 1 Astronomical Unit (AU), includes 10 percent margin) ultra-flex solar arrays provided power to the stage, with Li-ion batteries for launch and contingency operations power. The base structure was an Al-Li hexagonal skin-stringer frame built to withstand launch loads. A passive thermal control system consisted of heat pipes to north and south radiator panels, multilayer insulation (MLI) and heaters for the Xe tank. All systems except tanks and solar arrays were designed to be single fault tolerant.

  20. Selected examples on multi physics researches at KFKI AEKI-results for phase I of the OECD/NEA UAM benchmark

    International Nuclear Information System (INIS)

    Panka, I.; Kereszturi, A.; Maraczy, C.

    2010-01-01

    Nowadays, there is a tendency to use best estimate plus uncertainty methods in the field of nuclear energy. This implies the application of best estimate code systems and the determination of the corresponding uncertainties. For the latter one an OECD benchmark was set up. The objective of the OECD/NEA Uncertainty Analysis in Best-Estimate Modeling (UAM) LWR benchmark is to determine the uncertainties of the coupled reactor physics/thermal hydraulics LWR calculations at all stages. In this paper the AEKI participation in Phase I will be presented. This Phase is dealing with the evaluation of the uncertainties of the neutronic calculations starting from the pin cell spectral calculations up to the stand-alone neutronics core simulations. (Authors)

  1. Treatment results of Stage I and II oral tongue cancer with interstitial brachytherapy: maximum tumor thickness is prognostic of nodal metastasis

    International Nuclear Information System (INIS)

    Matsuura, Kanji; Hirokawa, Yutaka; Fujita, Minoru; Akagi, Yukio; Ito, Katsuhide

    1998-01-01

    Purpose: To evaluate the prognostic importance of T classification and maximum tumor thickness (MTT) on the treatment results of Stage I and II oral tongue cancer treated with interstitial brachytherapy. Methods and Materials: Between January 1981 and December 1993, 173 cases were eligible for this retrospective analysis. Of 173 patients, 75 were classified as Stage I and 98 as Stage II: maximum tumor length ranged from 6 to 40 mm. MTT, which ranged from 2 to 38 mm, was measured with ultrasonography and/or palpation. Brachytherapy was performed with iridium hairpins or radium needles following external irradiation in 66 patients, or exclusively in 107 patients. Results: The 5-year local recurrence rates were Stage I, 7%; Stage II, 22%; MTT < 8 mm, 8%; and MTT ≥ 8 mm, 28%. The 5-year regional recurrence rates were Stage I, 15%; Stage II, 29%; MTT < 8 mm, 18%; and MTT ≥ 8 mm, 31%, respectively. The 5-year local recurrence rates of the patients with Stage I and MTT < 8 mm of the brachytherapy only group were significantly better than those of Stage II and MTT ≥ 8 mm (5% and 6% vs. 16% and 24%). The 5-year regional recurrence rates of the patients with Stage I and MTT < 8 mm of the brachytherapy-only group were significantly better than those of Stage II and MTT ≥ 8 mm (14% and 16% vs. 34% and 46%). There was no significant difference in the 5-year regional recurrence rates between the two groups of Stage I and Stage II, MTT < 8 mm. However, there was a significant difference in the 5-year regional recurrence rates between the two groups of MTT ≥ 8 mm (p < 0.005). Conclusions: For patients with Stage I and II oral tongue cancer, tumor thickness as well as T classification were prognostic for nodal metastasis and prognosis. Patients with MTT ≥ 8 mm are more likely to fail in the neck region. These findings suggest that MTT should be considered along with T stage in determining strategies for Stage I and II oral tongue cancer

  2. Barriers to the Implementation of Surveillance for Stage I Testicular Seminoma

    International Nuclear Information System (INIS)

    Arvold, Nils D.; Catalano, Paul J.; Sweeney, Christopher J.; Hoffman, Karen E.; Nguyen, Paul L.; Balboni, Tracy A.; Fosså, Sophie D.; Travis, Lois B.; Beard, Clair J.

    2012-01-01

    Purpose: Postorchiectomy adjuvant radiotherapy (RT) for Stage I seminoma can be associated with long-term toxicity, and management strategies with a lower treatment burden achieve the same excellent cure rate. Because studies suggest that radiation oncologists in the United States continue to recommend RT for these patients, we sought to identify factors associated with management recommendations. Methods and Materials: We conducted a one-time internet-based survey among 491 randomly selected American radiation oncologists self-described as specializing in genitourinary oncology. Results: Response rate was 53% (n = 261). Forty-nine percent of respondents worked in university-affiliated practices. Sixty-two percent of respondents always/usually recommended adjuvant RT for patients with Stage I seminoma, whereas 21% always/usually recommended surveillance and 3% always/usually recommended chemotherapy. One third (33%) expressed concerns that patients who experienced relapse during surveillance could not be salvaged. Although 88% of physicians were aware of an increased risk of second malignant neoplasms (SMN) after adjuvant RT, 85% underestimated its magnitude. Compared with physicians not typically recommending RT, physicians who always/usually recommended RT were more likely to believe that patients might not be salvaged at relapse during surveillance (p = 0.008) and were less aware of the association between RT and SMN (p = 0.04). Conclusions: Respondents who always/usually recommend postorchiectomy RT for patients with Stage I seminoma are more likely to underestimate late RT morbidity and to believe that surveillance is associated with increased mortality. Given the equivalent efficacy and reduced morbidity of surveillance compared with RT, our findings underscore the need for ongoing physician education to increase appropriate clinical implementation of surveillance strategies.

  3. Barriers to the Implementation of Surveillance for Stage I Testicular Seminoma

    Energy Technology Data Exchange (ETDEWEB)

    Arvold, Nils D. [Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts (United States); Catalano, Paul J. [Department of Biostatistics, Harvard School of Public Health, and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Sweeney, Christopher J. [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Hoffman, Karen E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Nguyen, Paul L.; Balboni, Tracy A. [Department of Radiation Oncology, Brigham and Women' s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Fossa, Sophie D. [Department of Clinical Research, Norwegian Radium Hospital, Oslo University, Oslo (Norway); Travis, Lois B. [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Beard, Clair J., E-mail: cbeard@lroc.harvard.edu [Department of Radiation Oncology, Brigham and Women' s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts (United States)

    2012-10-01

    Purpose: Postorchiectomy adjuvant radiotherapy (RT) for Stage I seminoma can be associated with long-term toxicity, and management strategies with a lower treatment burden achieve the same excellent cure rate. Because studies suggest that radiation oncologists in the United States continue to recommend RT for these patients, we sought to identify factors associated with management recommendations. Methods and Materials: We conducted a one-time internet-based survey among 491 randomly selected American radiation oncologists self-described as specializing in genitourinary oncology. Results: Response rate was 53% (n = 261). Forty-nine percent of respondents worked in university-affiliated practices. Sixty-two percent of respondents always/usually recommended adjuvant RT for patients with Stage I seminoma, whereas 21% always/usually recommended surveillance and 3% always/usually recommended chemotherapy. One third (33%) expressed concerns that patients who experienced relapse during surveillance could not be salvaged. Although 88% of physicians were aware of an increased risk of second malignant neoplasms (SMN) after adjuvant RT, 85% underestimated its magnitude. Compared with physicians not typically recommending RT, physicians who always/usually recommended RT were more likely to believe that patients might not be salvaged at relapse during surveillance (p = 0.008) and were less aware of the association between RT and SMN (p = 0.04). Conclusions: Respondents who always/usually recommend postorchiectomy RT for patients with Stage I seminoma are more likely to underestimate late RT morbidity and to believe that surveillance is associated with increased mortality. Given the equivalent efficacy and reduced morbidity of surveillance compared with RT, our findings underscore the need for ongoing physician education to increase appropriate clinical implementation of surveillance strategies.

  4. Final Report: ATLAS Phase-2 Tracker Upgrade Layout Task Force

    CERN Document Server

    Clark, A; The ATLAS collaboration; Hessey, N; Mättig, P; Styles, N; Wells, P; Burdin, S; Cornelissen, T; Todorov, T; Vankov, P; Watson, I; Wenig, S

    2012-01-01

    he mandate of the Upgrade Layout Task Force was to develop a benchmark layout proposal for the ATLAS Phase-2 Upgrade Letter of Intent (LOI), due in late 2012. The work described in this note has evolved from simulation and design studies made using an earlier "UTOPIA" upgrade tracker layout, and experience gained from the current ATLAS Inner Detector during the first years of data taking. The layout described in this document, called the LoI-layout, will be used as a benchmark layout for the LoI and will be used for simulation and engineering studies described in the LoI.

  5. Improved Metal-Polymeric Laminate Radiation Shielding, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this proposed Phase I program, a multifunctional lightweight radiation shield composite will be developed and fabricated. This structural radiation shielding will...

  6. High Impulse Nanoparticulate-Based Gel Propellants, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed Small Business Innovative Research (SBIR) Phase I addresses the development of advanced gel propellants and determination of their suitability for...

  7. Mitotic effects of monochromatic ultraviolet radiation at 225, 265, and 280 nm on eleven stages of the cell cycle of the grasshopper neuroblast in culture. I. Overall retardation from the stage irradiated to nuclear membrane breakdown

    International Nuclear Information System (INIS)

    Carlson, J.G.

    1976-01-01

    Neuroblasts of Chortophaga viridifasciata (DeGeer) in culture were exposed to different doses of 225, 265, or 280 nm ultraviolet radiations at 11 different stages and substages of the mitotic cycle and individually selected cells were timed to breakdown of the nuclear membrane. Comparisons of the effectiveness of different wavelengths on the different stages were based on the dose that reduced the cell progression rate to 67 percent of normal (D 67 ) and the slope of the regression line, i.e., the control to treated time (C/T) ratio change/erg/mm 2 at the D 67 level. Cells of the prereplication period (metaphase + anaphase + early telophase) and the S phase (middle and late telophase + interphase + very early prophase) are equally sensitive to uv and contrast sharply with the much lower sensitivity of those in the postreplication period (early and middle prophase). This can best be interpreted if chromosomal DNA is the chromophore for uv-induced mitotic retardation. Cells in the prereplication period at exposure show no wavelength effect. In the S phase all stages except middle telophase and all stages combined are significantly more sensitive to 265 and 280 nm than to 225 nm. Of the postreplication stages, early prophase is retarded significantly more by 280 than by 225 or 265 nm. The C/T ratio/erg/mm 2 is greater after exposure to 265 nm at all prereplication and replication stages, but exhibits no consistent wavelength pattern during the postreplication period. Evidence based on the orientation of the neuroblast with respect to the uv-source suggests that the chromophore for mitotic retardation does not reside within the centrosome and related structures, but may be present, at least partly, in the nucleolus

  8. Dose-Escalated Robotic SBRT for Stage I-II Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Robert eMeier

    2015-04-01

    Full Text Available Abstract: Stereotactic body radiotherapy (SBRT is the precise external delivery of very high-dose radiotherapy to targets in the body, with treatment completed in one to five fractions. SBRT should be an ideal approach for organ-confined prostate cancer because (I dose escalation should yield improved rates of cancer control; (II the unique radiobiology of prostate cancer favors hypofractionation and (III the conformal nature of SBRT minimizes high-dose radiation delivery to immediately adjacent organs, potentially reducing complications. This approach is also more convenient for patients, and is cheaper than intensity modulated radiotherapy (IMRT. Several external beam platforms are capable of delivering SBRT for early-stage prostate cancer, although most of the mature reported series have employed a robotic non-coplanar platform (i.e., CyberKnife. Several large studies report 5-year biochemical relapse rates which compare favorably to IMRT. Rates of late GU toxicity are similar to those seen with IMRT, and rates of late rectal toxicity may be less than with IMRT and low dose rate (LDR brachytherapy. Patient-reported quality of life (QOL outcomes appear similar to IMRT in the urinary domain. Bowel QOL may be less adversely affected by SBRT than with other radiation modalities. After five years of follow-up, SBRT delivered on a robotic platform is yielding outcomes at least as favorable as IMRT, and may be considered appropriate therapy for stage I-II prostate cancer.

  9. Final work plan : Phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Savannah, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-10-12

    . This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigative activities at Savannah will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with the DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Savannah will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Savannah investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Savannah site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne will issue a Provisional Master Work Plan (PMWP; Argonne 2007) that will be submitted to the MoDNR for review and approval. The agency has already reviewed and approved (with minor changes) the present Master Work Plan (Argonne 2002) under which Argonne currently operates in Kansas. The PMWP (Argonne 2007) will provide detailed information and guidance on the investigative technologies, analytical methodologies, quality assurance-quality control measures, and general health and safety policies to be employed by

  10. LHC Interaction Region Upgrade Phase I

    CERN Document Server

    Ostojic, R

    2009-01-01

    The LHC is starting operation with beam in 2008. The primary goal of CERN and the LHC community is to ensure that the collider is operated efficiently, maximizing its physics reach, and to achieve the nominal performance in the shortest term. Since several years the community has been discussing the directions for upgrading the experiments, in particular ATLAS and CMS, the LHC machine and the CERN proton injector complex. A well substantiated and coherent scenario for the first phase of the upgrade, which is foreseen in 2013, is now approved by CERN Council. In this paper, we present the goals and the proposed conceptual solution for the Phase-I upgrade of the LHC interaction regions. This phase relies on the mature Nb-Ti superconducting magnet technology, with the target of increasing the luminosity by a factor of 2-3 with respect to the nominal luminosity of 1034 cm-2s-1, while maximising the use of the existing infrastructure.

  11. Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation

    DEFF Research Database (Denmark)

    already spent on these technologies also lead to commercial success. The project ‘Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation’ was aiming at starting with the Establishment of such a center. The following report documents the achievements within the project...... of the fluctuating wind energy. As the fuel cell and hydrogen technologies come closer to commercialization, development of testing methodology, qualified testing and demonstration become increasingly important. Danish industrial players have expressed a strong need for support in the process to push fuel cell...... and hydrogen technologies from the research and development stage into the commercial domain. A Center to support industry with test, development, analysis, approval, certification, consultation, and training in the areas of fuel cell and hydrogen technologies was needed. Denmark has demonstrated leading...

  12. Friction Stir Processing of Cast Superalloys, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort examines the feasibility of an innovative fabrication technology incorporating sand casting and friction stir processing (FSP) for producing...

  13. GTS Duratek, Phase I Hanford low-level waste melter tests: 100-kg melter offgas report

    International Nuclear Information System (INIS)

    Eaton, W.C.

    1995-11-01

    A multiphase program was initiated in 1994 to test commercially available melter technologies for the vitrification of the low-level waste (LLW) stream from defense wastes stored in underground tanks at the Hanford Site in southeastern Washington State. Phase 1 of the melter demonstration tests using simulated LLW was completed during fiscal year 1995. This document is the 100-kg melter offgas report on testing performed by GTS Duratek, Inc., in Columbia, Maryland. GTS Duratek (one of the seven vendors selected) was chosen to demonstrate Joule heated melter technology under WHC subcontract number MMI-SVV-384215. The document contains the complete offgas report on the 100-kg melter as prepared by Parsons Engineering Science, Inc. A summary of this report is also contained in the GTS Duratek, Phase I Hanford Low-Level Waste Melter Tests: Final Report (WHC-SD-WM-VI-027)

  14. Trastuzumab Emtansine in Treating Older Patients With Human Epidermal Growth Factor Receptor 2-Positive Stage I-III Breast Cancer

    Science.gov (United States)

    2018-02-01

    Estrogen Receptor Status; HER2 Positive Breast Carcinoma; Progesterone Receptor Status; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage III Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  15. ABC transporters and xenobiotic defense systems in early life stages of rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Kropf, Christian; Segner, Helmut; Fent, Karl

    2016-01-01

    Embryos of oviparous fish, in contrast to (ovo) viviparous species, develop in the aquatic environment, and therefore need solute transport systems at their body surfaces for maintaining internal homeostasis and defending against potentially harmful substances. We hypothesized that solute transporters undergo changes in tissue distribution from the embryo to the larval stage. We therefore studied the mRNA profiles of eight ABC transporters (abcb1a, abcb1b, abcc1, abcc2, abcc3, abcc4, abcc5, abcg2) and three solute carriers (oatp1d, putative oatp2 putative, mate1) in different body regions (head, yolk sac epithelium, abdominal viscera, skin/muscles) of developing rainbow trout. Additionally, we investigated mRNA levels of phase I (cyp1a, cyp3a) and phase II (gstp, putative ugt1, putative ugt2) biotransformation enzymes. The study covered the developmental period from the eleuthero-embryo stage to the first-feeding larval stage (1-20days post-hatch, dph). At 1dph, transcripts of abcc2, abcc4, abcg2, cyp3a, gstp, putative mate1, and putative oatp2 occurred primarily in the yolk sac epithelium, whereas at later stages expression of these genes was predominantly observed in the abdominal viscera. The functional activity of ABC transporters in fish early life stages was assessed by rhodamine B accumulation assays. Finally, we investigated the potential impact of xenobiotics (clotrimazole, clofibric acid) on the ABC and biotransformation systems of trout early life stages. While clofibric acid had no effect, clotrimazole lead to an increased rhodamine B accumulation. The results provide evidence that the transition from the eleuthero-embryo to the larval stage is accompanied by a major alteration in tissue expression of ABC transporters. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Curative high dose rate vaginal apex brachytherapy in stage I papillary serous carcinoma of the endometrium

    International Nuclear Information System (INIS)

    Turner, B.C.; Kacinski, B.M.; Gumbs, A.; Peschel, R.E.; Haffty, B.G.; Wilson, L.D.

    1996-01-01

    Introduction: Uterine papillary serous carcinoma (UPSC) is a morphologically distinct variant of endometrial carcinoma that is associated with a poor prognosis, high recurrence rate, clinical understaging, and poor response to salvage treatment. We describe the presentation, local and distant control, survival, salvage rate, and complications for patients undergoing whole abdominal radiation therapy (WART), low dose rate (LDR) intracavitary brachytherapy, or high dose rate (HDR) vaginal brachytherapy in patients with stage I UPSC. Methods: Between 1976 and 1994 more than 1700 patients with endometrial carcinoma were treated with radiation therapy, 30 patients with stage I UPSC (1.8%) were treated with radiation before or following TAH/BSO. All patients underwent either preoperative Simon's packing or tandem and plaque which delivered 30-40 Gy to the serosa, WART, or HDR Ir-192 vaginal apex brachytherapy to a total dose of 21 Gy in 3 fractions at 0.5 cm from the vaginal mucosa. A total of 14 patients received HDR vaginal brachytherapy and (5(14)) patients received systemic chemotherapy. All patients presented with vaginal bleeding at a median age of 67 years (range 34-88). The group of 30 patients underwent TAH/BSO, 17 patients were completely staged pathologically (pelvic and para-aortic lymph nodes, omentectomy, and pelvic washings), and 2 patients underwent omental biopsy and pelvic washings only. All specimens revealed UPSC, nuclear grade 3, and lymphovascular invasion (23%). The pathologic stage was IA: 23% (7), IB: 67% (20), and IC: 10% (3). The median follow-up for all patients was 49 months (range 13-187 months). For the patients receiving postoperative HDR vaginal brachytherapy the median time from surgery to radiation was 42 days (range 29-91). Results: The 5-year actuarial disease free survival for Figo stage I UPSC patients treated with postoperative HDR vaginal brachytherapy and systemic chemotherapy was 100% compared to 74% for stage I UPSC patient

  17. Effects of induction docetaxel, platinum, and fluorouracil chemotherapy in patients with stage III or IVA/B nasopharyngeal cancer treated with concurrent chemoradiation therapy: Final results of 2 parallel phase 2 clinical trials.

    Science.gov (United States)

    Kong, Lin; Zhang, Youwang; Hu, Chaosu; Guo, Ye; Lu, Jiade J

    2017-06-15

    The effects of docetaxel, platinum, and fluorouracil (TPF) induction chemotherapy plus concurrent chemoradiotherapy (CCRT) on locoregionally advanced nasopharyngeal cancer (NPC) are unclear. This study examined the long-term outcomes of the addition of this regimen to CCRT for stage III and IVA/B NPC. Two parallel, single-arm phase 2 trials were performed synchronously to evaluate the efficacy and toxicity of TPF-based induction chemotherapy in patients with stage III or IVA/B NPC. The induction chemotherapy, which preceded standard intensity-modulated radiation therapy/platinum-based chemoradiation, consisted of 3 cycles of docetaxel (75 mg/m 2 on day 1), cisplatin (75 mg/m 2 on day 1), and a continuous infusion of fluorouracil (500 mg/m 2 /d on days 1-5) every 4 weeks. The primary endpoint for both trials was 5-year overall survival (OS). Between January 2007 and July 2010, 52 eligible patients with stage III NPC and 64 eligible patients with nonmetastatic stage IV NPC were accrued to the 2 trials. With a median follow-up of 67 months, the 5-year OS, progression-free survival, distant metastasis-free survival, and local progression-free survival (LPFS) rates were all improved in comparison with historical benchmarks for patients with stage III or IVA/IVB NPC. Multivariate analyses indicated that T and N classifications (T1/T2 vs T3/T4 and N3 vs N0-N2) were the only significant prognosticators for OS. The number of induction chemotherapy cycles was the only significant prognostic factor for predicting LPFS. TPF-based induction chemotherapy appears to significantly improve outcomes in comparison with historical data when it is administered before CCRT for locoregionally advanced NPC. A phase 3 trial is currently being performed to confirm this benefit. Cancer 2017;123:2258-2267. © 2017 American Cancer Society. © 2017 American Cancer Society.

  18. Formation of secondary phases during deep geological final disposal of research reactor fuel elements. Structure and phase analysis

    International Nuclear Information System (INIS)

    Neumann, Andreas

    2012-01-01

    For the assessment of a confident und sustainable final disposal of high level radioactive waste - fuel elements of german research reactors also account for such waste - in suitable, deep geological facilities, processes of the alteration of the disposed of waste and therefore the formation of the corrosion products, i. e. secondary phases must be well understood considering an accident scenario of a potential water inflow. In order to obtain secondary phases non-irradiated research reactor fuel elements (FR-BE) consisting of UAl x -Al were subjected to magnesium chloride rich brine (brine 2, salt repository) and to clay pore solution, respectively and furthermore of the type U 3 Si 2 -Al were solely subjected to magnesium chloride rich brine. Considering environmental aspects of final repositories the test conditions of the corrosion experiments were adjusted in a way that the temperature was kept constant at 90 C and a reducing anaerobic environment was ensured. As major objective of this research secondary phases, obtained from the autoclave experiments after appropriate processing and grain size separation have been identified and quantified. Powder X-ray diffraction (PXRD) and the application of Rietveld refinement methods allowed the identification of the corrosion products and a quantitative assessment of crystalline and amorphous contents. Scanning and transmission electron microscopy were additionally applied as a complementary method for the characterisation of the secondary phases. The qualitative phase analysis of the preprocessed secondary phases of the systems UAl x -Al and U 3 Si 2 -Al in brine 2 shows many similarities. Lesukite - an aluminium chloro hydrate - was observed for the first time considering the given experimental conditions. Further on different layered structures of the LDH type, iron oxyhydroxide and possibly iron chlorides, uncorroded residues of nuclear fuel and elementary iron were identified as well. Depending on preceding

  19. Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age.

    Science.gov (United States)

    Jiang, Xuan; Yang, Jiaxin; Yu, Mei; Xie, Weimin; Cao, Dongyan; Wu, Ming; Pan, Lingya; Huang, Huifang; You, Yan; Shen, Keng

    2017-08-15

    Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation.

  20. Planetary-Whigs: Optical MEMS-Based Seismometer, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — During this Phase I, Michigan Aerospace Corporation will adapt the design of an optical MEMS seismometer for lunar and other planetary science instrumentation. The...

  1. Inorganic Nanostructured High-Temperature Magnet Wires, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will develop a high-temperature tolerant electrically-insulating coating for magnet wires. The Phase I program will result in a flexible, inorganic...

  2. Mars Ascent Vehicle Reaction Control System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — During this Phase I NASA program, Valley Tech Systems (VTS) will develop an innovative solid Reaction Control System (RCS) architecture concept design that can...

  3. Self-Calibrating Vector Helium Magnetometer (SVHM), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR proposal describes proposed development of a conceptual design for a Self-Calibrating Vector Helium Magnetometer (SVHM) for design and fabrication...

  4. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: Clinical Phase I/II trials

    International Nuclear Information System (INIS)

    Chen Zhinan; Mi Li; Xu Jing

    2006-01-01

    Purpose: HAb18G/CD147 is a hepatocellular carcinoma (HCC)-associated antigen. We developed iodine ( 131 I) metuximab injection (Licartin), a novel 131 I-labeled HAb18G/CD147-specific monoclonal antibody F(ab') 2 fragment, and evaluated its safety, pharmacokinetics, and clinical efficacy on HCC in Phase I/II trials. Methods and Materials: In a Phase I trial, 28 patients were randomly assigned to receive the injection in 9.25-, 18.5-, 27.75-, or 37-MBq/kg doses by hepatic artery infusion. In a multicenter Phase II trial, 106 patients received the injection (27.75 MBq/kg) on Day 1 of a 28-day cycle. Response rate and survival rate were the endpoints. Results: No life-threatening toxic effects were found. The safe dosage was 27.75 MBq/kg. The blood clearance fitted a biphasic model, and its half-life was 90.56-63.93 h. In the Phase II trial, the injection was found to be targeted and concentrated to tumor tissues. Of the 73 patients completing two cycles, 6 (8.22%) had a partial response, 14 (19.18%) minor response, and 43 (58.90%) stable disease. The 21-month survival rate was 44.54%. The survival rate of progression-free patients was significantly higher than that of patients with progressive disease after either one or two cycles (p 131 I) metuximab injection is safe and active for HCC patients

  5. Aging of snubbers in nuclear service: Phase I study results and Phase II plans

    International Nuclear Information System (INIS)

    Goodman, R.L.; Bush, S.H.; Page, R.E.

    1988-01-01

    Two major research areas were investigated in the Phase I snubber aging studies. The first area involved a preliminary evaluation of the effects of various aging mechanisms on snubber operation; failure modes of mechanisms were identified and their contributions to aging degradation were assessed relative to other failure modes. The second area involved estimating the efficacy of existing tests and examinations that are intended to determine the effects of aging and degradation. Available data on snubber behavior and operating experience were reviewed, using licensee event reports and other historical data for the 10-year period from 1973 through 1983. Value-impact was considered in terms of (1) exposure of workers to radioactive environments for examination/testing and (2) the cost for expansion of the snubber testing program due to failed snubbers. Results from the Phase I studies identified the need to modify or improve examination and testing procedures to enhance snubber reliability. Based on the results of the Phase I snubber studies, the seals and fluids were identified as the two principal elements affected by aging degradation in hydraulic snubbers. Phase II work, which was initiated in FY 1987, will develop cooperative activities between PNL and operating utilities through the Snubber Utility Group (SNUG), who will work to establish a strong data and experience base for both hydraulic and mechanical snubbers based on actual operating and maintenance history at nuclear power plants. Application guidelines for snubbers will be recommended based on the study results

  6. Manufacturing For Design of Titanium Alloys, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I program proposes to exploit the tremendous benefits that could be offered by the development of a microstructural refinement and control technology...

  7. High Energy Single Frequency Resonant Amplifier, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR phase I project proposes a single frequency high energy resonant amplifier for remote sensing. Current state-of-art technologies can not provide all...

  8. Torrefaction Processing of Human Fecal Waste, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — New technology is needed to collect, stabilize, safen, recover useful materials, and store human fecal waste for long duration missions. The current SBIR Phase I...

  9. Novel Instrumentation for Rocket Propulsion Systems, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the proposed SBIR Phase I program is to develop novel laser-based instruments that provide rapid, in situ, simultaneous measurements of gas...

  10. Improved survival for women with stage I breast cancer in south-east Sweden: A comparison between two time periods before and after increased use of adjuvant systemic therapy

    International Nuclear Information System (INIS)

    Johansson, Patrik; Fohlin, Helena; Arnesson, Lars-Gunnar

    2009-01-01

    Purpose. Continuous minor steps of improvement in the management of breast cancer have resulted in decreased mortality rates during the last decades. The aim of this study was to compare the clinical outcome of patients with stage I breast cancer diagnosed during two time periods that differed with respect to adjuvant systemic therapy. Material and methods. The studied population consisted of all women < 60 years of age, who were diagnosed breast cancer stage I between 1986 and 1999 in south-east Sweden, a total of 1 407 cases. The cohort was divided into two groups based on the management programmes of 1986 and 1992, hereafter referred to as Period 1 and Period 2. Before 1992 the only adjuvant systemic therapy recommended was tamoxifen for hormone receptor positive patients aged 50 years or older. During Period 2 the use of adjuvant treatment was extended to younger patients at high risk, identified by a high tumour S-phase fraction, with either hormonal or cytotoxic treatment. Results. The estimated distant recurrence-free survival rate was significantly higher during Period 2 than during Period 1 (p = 0.008). Subgroup analysis showed that the most evident reduction of distant recurrence risk was among hormone receptor-negative patients (HR = 0.58, 95% CI 0.31-1.09, p = 0.09) and among patients with a high tumour S-phase fraction (HR = 0.53, 0.30-0.93, p = 0.028). The risk reduction between the periods was still statistically significant in multivariate analysis when adjusting for different tumour characteristics and treatment modalities, indicating an influence of other factors not controlled for. One such factor may be the duration of tamoxifen treatment, which likely was more frequently five years during Period 2 than during Period 1. Conclusions. We conclude that the causes of the increase in distant recurrence free survival for women with breast cancer stage I are complex. The results support though that high-risk subgroups of stage I breast cancer patients

  11. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia.

    Science.gov (United States)

    von Stackelberg, Arend; Locatelli, Franco; Zugmaier, Gerhard; Handgretinger, Rupert; Trippett, Tanya M; Rizzari, Carmelo; Bader, Peter; O'Brien, Maureen M; Brethon, Benoît; Bhojwani, Deepa; Schlegel, Paul Gerhardt; Borkhardt, Arndt; Rheingold, Susan R; Cooper, Todd Michael; Zwaan, Christian M; Barnette, Phillip; Messina, Chiara; Michel, Gérard; DuBois, Steven G; Hu, Kuolung; Zhu, Min; Whitlock, James A; Gore, Lia

    2016-12-20

    Purpose Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19 on B-cell lymphoblasts. We evaluated the safety, pharmacokinetics, recommended dosage, and potential for efficacy of blinatumomab in children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Methods This open-label study enrolled children treatment cycles. Primary end points were maximum-tolerated dosage (phase I) and complete remission rate within the first two cycles (phase II). Results We treated 49 patients in phase I and 44 patients in phase II. Four patients had dose-limiting toxicities in cycle 1 (phase I). Three experienced grade 4 cytokine-release syndrome (one attributed to grade 5 cardiac failure); one had fatal respiratory failure. The maximum-tolerated dosage was 15 µg/m 2 /d. Blinatumomab pharmacokinetics was linear across dosage levels and consistent among age groups. On the basis of the phase I data, the recommended blinatumomab dosage for children with relapsed/refractory ALL was 5 µg/m 2 /d for the first 7 days, followed by 15 µg/m 2 /d thereafter. Among the 70 patients who received the recommended dosage, 27 (39%; 95% CI, 27% to 51%) achieved complete remission within the first two cycles, 14 (52%) of whom achieved complete minimal residual disease response. The most frequent grade ≥ 3 adverse events were anemia (36%), thrombocytopenia (21%), and hypokalemia (17%). Three patients (4%) and one patient (1%) had cytokine-release syndrome of grade 3 and 4, respectively. Two patients (3%) interrupted treatment after grade 2 seizures. Conclusion This trial, which to the best of our knowledge was the first such trial in pediatrics, demonstrated antileukemic activity of single-agent blinatumomab with complete minimal residual disease response in children with relapsed/refractory BCP-ALL. Blinatumomab may represent an important new treatment option in this setting, requiring further investigation in curative indications.

  12. Maintenance phase in psoralen-ultraviolet A phototherapy of early-stage mycosis fungoides. A critically appraised topic.

    Science.gov (United States)

    Grandi, V; Delfino, C; Pileri, A; Pimpinelli, N

    2017-08-01

    A 65-year-old patient affected by mycosis fungoides (MF) stage IB achieved complete remission (CR) after a cycle of PUVA phototherapy. The U.S. Cutaneous Lymphoma Consortium (USCLC) guidelines suggest that the patient should be kept in the maintenance phase, defined as a 'period of gradual decrease of frequency of UVL [ultraviolet light] while in clinical remission before discontinuation of phototherapy' by slowly tapering the number of psoralen-ultraviolet A (PUVA) applications over time up to clinical relapse. The USCLC guidelines also suggest a standardized schedule for the maintenance phase. Alternatively, the patient could end PUVA therapy and go straight to follow-up. The aim of this critically appraised topic (CAT) was to determine if a maintenance phase gives a significant benefit in terms of relapse rate (RR) and RFI in patients affected by early-stage MF who had achieved CR under PUVA phototherapy. Embase, PubMed and TRIP databases were searched for 'mycosis fungoides' AND [('photochemotherapy' OR 'puva') OR 'psoralen'] in June 2016. Three articles matched our inclusion criteria and are discussed in this CAT. In this field of research the literature is poor and the reported level of evidence is low. Only one of the studies was conducted prospectively, and none were randomized. No significant difference in terms of reduction in relapse rate or increase in RFI in patients who underwent a PUVA maintenance phase emerged when compared with those who went for simple follow-up. Further randomized clinical trials (RCTs) are required in order to evaluate maintenance phase vs. no treatment before it can be favoured as the standard protocol of treatment in early-stage MF. At the time of writing this paper, we report an ongoing Austrian multicentre RCT (Clinical Trial.gov identifier: NCT01686594) that will hopefully give useful results in this topic. © 2017 British Association of Dermatologists.

  13. Plasma Control of Turbine Secondary Flows, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose Phase I and II efforts that will focus on turbomachinery flow control. Specifically, the present work will investigate active control in a high speed...

  14. Compact, High Accuracy CO2 Monitor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase I proposal seeks to develop a low cost, robust, highly precise and accurate CO2 monitoring system. This system will...

  15. Testicular cancer: seminoma. Stage I. Adjuvant radiotherapy. Results at 3 years

    International Nuclear Information System (INIS)

    Lione, M.; Ticera, N.; Mandachain, M.

    2008-01-01

    Full text: Purpose: To evaluate the results achieved with adjuvant radiotherapy. Materials and methods: We analyzed 40 medical records of patients diagnosed with stage I of testicular cancer, all of them received adjuvant radiotherapy between April 1992 and May 2004. The histological type was classical seminoma (95%) and spermatocytes (5%). Diagnosis and staging were performed with testicular ultrasound, determination of tumor markers, computed tomography of abdomen - pelvis and chest radiographs. Radiotherapy: Patients were treated with 60 Co unit and a linear accelerator of 6 MV photons. Volumes: Group I: lumboaortic lymph node region and ipsilateral pelvis. Group II: lumboaortic only. Daily dose: 1.8 Gy, total dose: 30.6 Gy. Patient in supine position, 2 parallel fields and opposed, DFP: 80 cm, calculated from midplane. They were followed for 3 years with chest X-ray, CAT scan of abdomen and pelvis at 12 months and then a full clinical control 1 time per year. Results: We defined the rate of ipsilateral pelvic node recurrence (group I: 0% vs. Group II: 6.25%), progression at distance (group I: 8.3% vs. Group II: 0%) and global survival (GS) (group I: 100% vs. group II: 100%) at 3 years of follow up. Conclusions: Our result is similar to that published in the international literature. Given the small number of patients, no evidence of changes in GS with the addition of radiotherapy to ipsilateral pelvic node. Radiation therapy to lumboaortic lymph nodes is the usual treatment, being necessary to optimize the modality of radiotherapy (RC3D - IRMT) to reduce toxicity in a long term. (authors) [es

  16. Early stages of bipolar disorder: characterization and strategies for early intervention

    Directory of Open Access Journals (Sweden)

    Adiel C. Rios

    2015-12-01

    Full Text Available Objective: To characterize the early stages of bipolar disorder (BD, defined as the clinical prodrome/subsyndromal stage and first-episode phase, and strategies for their respective treatment. Methods: A selective literature search of the PubMed, Embase, PsycINFO, and ISI databases from inception until March 2014 was performed. Included in this review were articles that a characterized prodromal and first-episode stages of BD or b detailed efficacy and safety/tolerability of interventions in patients considered prodromal for BD or those with only one episode of mania/hypomania. Results: As research has only recently focused on characterization of the early phase of BD, there is little evidence for the effectiveness of any treatment option in the early phase of BD. Case management; individual, group, and family therapy; supportive therapy; and group psychoeducation programs have been proposed. Most evidence-based treatment guidelines for BD do not address treatment specifically in the context of the early stages of illness. Evidence for pharmacotherapy is usually presented in relation to illness polarity (i.e., manic/mixed or depressed or treatment phase. Conclusions: Although early recognition and treatment are critical to preventing unfavorable outcomes, there is currently little evidence for interventions in these stages of BD.

  17. Final closure of the Panamaian Isthmus and the onset of northern hemisphere glaciation

    Science.gov (United States)

    Sarnthein, M.; Bartoli, G.; Weinelt, M.; Erlenkeuser, H.; Garbe-Schoenberg, D.; Lea, D. W.

    2005-12-01

    The Greenland ice sheet forms a key factor controlling the Quaternary-style glacial scenario. However, origin and mechanisms of major Arctic glaciation starting at 3.15 Ma and culminating at 2.74 Ma have remained controversial. For this phase of intense cooling Ravelo et al. (2004) proposed a complex gradual forcing mechanism. In contrast, our new submillennial-scale paleoceanographic records from the Pliocene North Atlantic suggest a far more precise timing and forcing for the initiation of northern hemisphere glaciation (NHG), since it was linked to a 2-3 /degC surface water warming during warm stages from 2.95 to 2.82 Ma (until glacial stage G10). These records support previous models (Haug and Tiedemann, 1998) claiming that the final closure of the Panama Isthmus (3.0 - ~2.5 Ma; Groeneveld, 2005) induced an increased poleward salt and heat transport. Associated strengthening of North Atlantic thermohaline circulation and in turn, an intensified moisture supply to northern high latitudes resulted in the build-up of NHG, finally culminating in the great, irreversible climate crash at glacial stage G6 (2.74 Ma). In summary, we see a two-step threshold mechanism that marked the onset of NHG with glacial-to-interglacial cycles quasi-persistent until today. G r o e n e v e l d, J., The final closure of the Central American Seaway. PhD Thesis Kiel, 2005. H a u g, G. and T i e d e m a n n , R., 1 9 9 8. Nature 393, 676-678. R a v e l o , A.C., e t a l ., 2004. Nature 429, 263-267.

  18. Final Report for the ADMX Phase 2a Project at the University of Washington

    International Nuclear Information System (INIS)

    Rosenberg, Leslie J.

    2015-01-01

    This is a final report of the ADMX (Axion Dark Matter eXperiment) Phase 2a program. This program is a project allowing for a sensitive axion dark-matter search at higher axion masses. The Phase 2a program also prepares the project for lower temperature anticipated in later operations. The Phase 2a program includes sensitive data-taking operations at two cavity modes, TM010 and TM020, allowing for faster data-taking operations and extending the search to higher and plausible dark-matter axion masses.

  19. Multi-layer Far-Infrared Component Technology, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR will demonstrate the feasibility of a process to create multi-layer thin-film optics for the far-infrared/sub-millimeter wave spectral region. The...

  20. Feasibility of sentinel node lymphoscintigraphy in stage I testicular cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tanis, Pieter J.; Nieweg, Omgo E. [Department of Surgery, Netherlands Cancer Institute, Amsterdam (Netherlands); Horenblas, Simon [Department of Urology, Netherlands Cancer Institute, Amsterdam (Netherlands); Olmos, Renato Valdes A.; Hoefnagel, Cornelis A. [Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam (Netherlands)

    2002-05-01

    The aim of this study was to investigate the feasibility of lymphoscintigraphy for sentinel node identification in testicular cancer. Five patients with clinical stage I testicular cancer were prospectively included. A single dose of technetium-99m nanocolloid (mean dose 99 MBq, volume 0.2 ml) was injected into the funiculus in the first patient and into the testicular parenchyma in the following four patients. Dynamic lymphoscintigraphy was performed over 10 min, followed by early and late static images after 15 min and 2 to 24 h, respectively. Lymphoscintigraphy was followed by laparoscopic sentinel node biopsy on the same day in the last two patients using patent blue dye and an endoscopic gamma probe. The funicular administration route showed five hot spots in the right inguinal region after 2 h. Intratesticular administration resulted in sentinel node visualisation in three of the four patients. Dynamic images showed afferent lymphatic vessels to one sentinel node in the left para-aortic region in two patients and two sentinel nodes in the left para-aortic region in another patient. Sentinel nodes were intraoperatively identified in one of two patients who underwent laparoscopic exploration. It is concluded that lymphoscintigraphy for sentinel node identification is feasible in stage I testicular cancer using intratesticular radiocolloid administration. (orig.)

  1. Development of Zinc/Bromine Batteries for Load-Leveling Applications: Phase 2 Final Report

    Energy Technology Data Exchange (ETDEWEB)

    CLARK,NANCY H.; EIDLER,PHILLIP

    1999-10-01

    This report documents Phase 2 of a project to design, develop, and test a zinc/bromine battery technology for use in utility energy storage applications. The project was co-funded by the U.S. Department of Energy Office of Power Technologies through Sandia National Laboratories. The viability of the zinc/bromine technology was demonstrated in Phase 1. In Phase 2, the technology developed during Phase 1 was scaled up to a size appropriate for the application. Batteries were increased in size from 8-cell, 1170-cm{sup 2} cell stacks (Phase 1) to 8- and then 60-cell, 2500-cm{sup 2} cell stacks in this phase. The 2500-cm{sup 2} series battery stacks were developed as the building block for large utility battery systems. Core technology research on electrolyte and separator materials and on manufacturing techniques, which began in Phase 1, continued to be investigated during Phase 2. Finally, the end product of this project was a 100-kWh prototype battery system to be installed and tested at an electric utility.

  2. The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer

    DEFF Research Database (Denmark)

    Bandak, Mikkel; Aksglaede, Lise; Juul, Anders

    2011-01-01

    This study investigates the pituitary-Leydig cell axis in patients with stage I testicular germ cell cancer (TGCC) followed with surveillance only, in order to evaluate the risk of Leydig cell dysfunction one year after orchiectomy.......This study investigates the pituitary-Leydig cell axis in patients with stage I testicular germ cell cancer (TGCC) followed with surveillance only, in order to evaluate the risk of Leydig cell dysfunction one year after orchiectomy....

  3. Carolina Offshore Wind Integration Case Study: Phases I and II Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Fallon, Christopher [Duke Energy Business Services, LLC, Charlotte, NC (United States); Piper, Orvane [Duke Energy Business Services, LLC, Charlotte, NC (United States); Hazelip, William [Duke Energy Business Services, LLC, Charlotte, NC (United States); Zhao, Yishan [Duke Energy Business Services, LLC, Charlotte, NC (United States); Salvador, Lisa [Duke Energy Business Services, LLC, Charlotte, NC (United States); Pruitt, Tom [Duke Energy Business Services, LLC, Charlotte, NC (United States); Peterson, Jeffrey [Duke Energy Business Services, LLC, Charlotte, NC (United States); Ashby, Rebecca [Duke Energy Business Services, LLC, Charlotte, NC (United States); Pierce, Bob [Duke Energy Business Services, LLC, Charlotte, NC (United States); Burner, Bob [Duke Energy Business Services, LLC, Charlotte, NC (United States); Daniel, John [ABB, Inc., Cary, NC (United States); Zhu, Jinxiang [ABB, Inc., Cary, NC (United States); Moore, Maria [ABB, Inc., Cary, NC (United States); Liu, Shu [ABB, Inc., Cary, NC (United States); Pennock, Ken [AWS Truepower, LLC, Albany, NY (United States); Frank, Jaclyn [AWS Truepower, LLC, Albany, NY (United States); Ibanez, Eduardo [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heaney, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bloom, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhang, Yingchen [National Renewable Energy Lab. (NREL), Golden, CO (United States); Elliott, Dennis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Seim, Harvey E. [Univ. of North Carolina, Chapel Hill, NC (United States)

    2015-04-30

    Duke Energy performed a phase 1 study to assess the impact of offshore wind development in the waters off the coasts of North Carolina and South Carolina. The study analyzed the impacts to the Duke Energy Carolinas electric power system of multiple wind deployment scenarios. Focusing on an integrated utility system in the Carolinas provided a unique opportunity to assess the impacts of offshore wind development in a region that has received less attention regarding renewables than others in the US. North Carolina is the only state in the Southeastern United States that currently has a renewable portfolio standard (RPS) which requires that 12.5% of the state’s total energy requirements be met with renewable resources by 2021. 12.5% of the state’s total energy requirements in 2021 equates to approximately 17,000 GWH of energy needed from renewable resources. Wind resources represent one of the ways to potentially meet this requirement. The study builds upon and augments ongoing work, including a study by UNC to identify potential wind development sites and the analysis of impacts to the regional transmission system performed by the NCTPC, an Order 890 planning entity of which DEC is a member. Furthermore, because the region does not have an independent system operator (ISO) or regional transmission organization (RTO), the study will provide additional information unique to non-RTO/ISO systems. The Phase 2 study builds on the results of Phase 1 and investigates the dynamic stability of the electrical network in Task 4, the operating characteristics of the wind turbines as they impact operating reserve requirements of the DEC utility in Task 5, and the production cost of integrating the offshore wind resources into the DEC generation fleet making comparisons to future planned operation without the addition of the wind resources in Task 6.

  4. Phase transformations in a human tooth tissue at the initial stage of caries.

    Directory of Open Access Journals (Sweden)

    Pavel Seredin

    Full Text Available The aim of the paper is to study phase transformations in solid tissues of the human teeth during the development of fissure caries by Raman and fluorescence microspectroscopy. The study of the areas with fissure caries confirmed the assumption of the formation of a weak interaction between phosphate apatite enamel and organic acids (products of microorganisms. The experimental results obtained with by Raman microspectroscopy showed the formation of dicalcium phosphate dihydrate - CaHPO4-2H2O in the area of mural demineralization of carious fissure. A comparative analysis of structural and spectroscopic data for the intact and carious enamel shows that emergence of a more soluble phase - carbonate-substituted hydroxyapatite - is typical for the initial stage of caries. It is shown that microareas of dental hard tissues in the carious fissure due to an emerging misorientation of apatite crystals have a higher fluorescence yield than the area of the intact enamel. These areas can be easily detected even prior to a deep demineralization (white spot stage for the case of irreversibly changed organomineral complex and intensive removal of the mineral component.

  5. Phase Transformations in a Human Tooth Tissue at the Initial Stage of Caries

    Science.gov (United States)

    Prutskij, Tatiana; Ippolitov, Yury

    2015-01-01

    The aim of the paper is to study phase transformations in solid tissues of the human teeth during the development of fissure caries by Raman and fluorescence microspectroscopy. The study of the areas with fissure caries confirmed the assumption of the formation of a weak interaction between phosphate apatite enamel and organic acids (products of microorganisms). The experimental results obtained with by Raman microspectroscopy showed the formation of dicalcium phosphate dihydrate - CaHPO4-2H2O in the area of mural demineralization of carious fissure. A comparative analysis of structural and spectroscopic data for the intact and carious enamel shows that emergence of a more soluble phase - carbonate-substituted hydroxyapatite - is typical for the initial stage of caries. It is shown that microareas of dental hard tissues in the carious fissure due to an emerging misorientation of apatite crystals have a higher fluorescence yield than the area of the intact enamel. These areas can be easily detected even prior to a deep demineralization (white spot stage) for the case of irreversibly changed organomineral complex and intensive removal of the mineral component. PMID:25901743

  6. Breast carcinoma conservative treatment. Stages I and II; Tratamento conservador do carcinoma mamario. Estadios I e II

    Energy Technology Data Exchange (ETDEWEB)

    Monti, C.R.

    1990-12-31

    From 1981 to 1988, 265 patients with breast cancer stages I and II (UICC-1987), were evaluated after conservative treatment with quadrantectomy plus axillectomy, radiotherapy and chemotherapy. After surgical treatment, the patients were submitted to radiation therapy in the breast. One hundred and fifty six (58,8%) patients were submitted to adjuvant chemotherapy. The median clinical follow-up period was 42.8 months with a minimum of 24 and a maximum of 99 months. Six (2,3%) patients presented local recurrence and 48 (18,1%) presented distant metastasis. After five years the total survival rate was 89,7% and the disease free survival rate was 75% in the same period. The study did not show significant differences among the clinical stages classified after surgery and the use of adjuvant chemotherapy did not influence the results of the many stages. (author). 194 refs, 33 figs, 6 tabs.

  7. Breast carcinoma conservative treatment. Stages I and II; Tratamento conservador do carcinoma mamario. Estadios I e II

    Energy Technology Data Exchange (ETDEWEB)

    Monti, C R

    1991-12-31

    From 1981 to 1988, 265 patients with breast cancer stages I and II (UICC-1987), were evaluated after conservative treatment with quadrantectomy plus axillectomy, radiotherapy and chemotherapy. After surgical treatment, the patients were submitted to radiation therapy in the breast. One hundred and fifty six (58,8%) patients were submitted to adjuvant chemotherapy. The median clinical follow-up period was 42.8 months with a minimum of 24 and a maximum of 99 months. Six (2,3%) patients presented local recurrence and 48 (18,1%) presented distant metastasis. After five years the total survival rate was 89,7% and the disease free survival rate was 75% in the same period. The study did not show significant differences among the clinical stages classified after surgery and the use of adjuvant chemotherapy did not influence the results of the many stages. (author). 194 refs, 33 figs, 6 tabs.

  8. Technology verification phase. Dynamic isotope power system. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Halsey, D.G.

    1982-03-10

    The Phase I requirements of the Kilowatt Isotope Power System (KIPS) program were to make a detailed Flight System Conceptual Design (FSCD) for an isotope fueled organic Rankine cycle power system and to build and test a Ground Demonstration System (GDS) which simulated as closely as possible the operational characteristics of the FSCD. The activities and results of Phase II, the Technology Verification Phase, of the program are reported. The objectives of this phase were to increase system efficiency to 18.1% by component development, to demonstrate system reliability by a 5000 h endurance test and to update the flight system design. During Phase II, system performance was improved from 15.1% to 16.6%, an endurance test of 2000 h was performed while the flight design analysis was limited to a study of the General Purpose Heat Source, a study of the regenerator manufacturing technique and analysis of the hardness of the system to a laser threat. It was concluded from these tests that the GDS is basically prototypic of a flight design; all components necessary for satisfactory operation were demonstrated successfully at the system level; over 11,000 total h of operation without any component failure attested to the inherent reliability of this type of system; and some further development is required, specifically in the area of performance. (LCL)

  9. Technology verification phase. Dynamic isotope power system. Final report

    International Nuclear Information System (INIS)

    Halsey, D.G.

    1982-01-01

    The Phase I requirements of the Kilowatt Isotope Power System (KIPS) program were to make a detailed Flight System Conceptual Design (FSCD) for an isotope fueled organic Rankine cycle power system and to build and test a Ground Demonstration System (GDS) which simulated as closely as possible the operational characteristics of the FSCD. The activities and results of Phase II, the Technology Verification Phase, of the program are reported. The objectives of this phase were to increase system efficiency to 18.1% by component development, to demonstrate system reliability by a 5000 h endurance test and to update the flight system design. During Phase II, system performance was improved from 15.1% to 16.6%, an endurance test of 2000 h was performed while the flight design analysis was limited to a study of the General Purpose Heat Source, a study of the regenerator manufacturing technique and analysis of the hardness of the system to a laser threat. It was concluded from these tests that the GDS is basically prototypic of a flight design; all components necessary for satisfactory operation were demonstrated successfully at the system level; over 11,000 total h of operation without any component failure attested to the inherent reliability of this type of system; and some further development is required, specifically in the area of performance

  10. Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses

    International Nuclear Information System (INIS)

    Zhang Qiang; Pi Jingbo; Woods, Courtney G.; Andersen, Melvin E.

    2009-01-01

    Hormetic responses to xenobiotic exposure likely occur as a result of overcompensation by the homeostatic control systems operating in biological organisms. However, the mechanisms underlying overcompensation that leads to hormesis are still unclear. A well-known homeostatic circuit in the cell is the gene induction network comprising phase I, II and III metabolizing enzymes, which are responsible for xenobiotic detoxification, and in many cases, bioactivation. By formulating a differential equation-based computational model, we investigated in this study whether hormesis can arise from the operation of this gene/enzyme network. The model consists of two feedback and one feedforward controls. With the phase I negative feedback control, xenobiotic X activates nuclear receptors to induce cytochrome P450 enzyme, which bioactivates X into a reactive metabolite X'. With the phase II negative feedback control, X' activates transcription factor Nrf2 to induce phase II enzymes such as glutathione S-transferase and glutamate cysteine ligase, etc., which participate in a set of reactions that lead to the metabolism of X' into a less toxic conjugate X''. The feedforward control involves phase I to II cross-induction, in which the parent chemical X can also induce phase II enzymes directly through the nuclear receptor and indirectly through transcriptionally upregulating Nrf2. As a result of the active feedforward control, a steady-state hormetic relationship readily arises between the concentrations of the reactive metabolite X' and the extracellular parent chemical X to which the cell is exposed. The shape of dose-response evolves over time from initially monotonically increasing to J-shaped at the final steady state-a temporal sequence consistent with adaptation-mediated hormesis. The magnitude of the hormetic response is enhanced by increases in the feedforward gain, but attenuated by increases in the bioactivation or phase II feedback loop gains. Our study suggests a

  11. Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses.

    Science.gov (United States)

    Zhang, Qiang; Pi, Jingbo; Woods, Courtney G; Andersen, Melvin E

    2009-06-15

    Hormetic responses to xenobiotic exposure likely occur as a result of overcompensation by the homeostatic control systems operating in biological organisms. However, the mechanisms underlying overcompensation that leads to hormesis are still unclear. A well-known homeostatic circuit in the cell is the gene induction network comprising phase I, II and III metabolizing enzymes, which are responsible for xenobiotic detoxification, and in many cases, bioactivation. By formulating a differential equation-based computational model, we investigated in this study whether hormesis can arise from the operation of this gene/enzyme network. The model consists of two feedback and one feedforward controls. With the phase I negative feedback control, xenobiotic X activates nuclear receptors to induce cytochrome P450 enzyme, which bioactivates X into a reactive metabolite X'. With the phase II negative feedback control, X' activates transcription factor Nrf2 to induce phase II enzymes such as glutathione S-transferase and glutamate cysteine ligase, etc., which participate in a set of reactions that lead to the metabolism of X' into a less toxic conjugate X''. The feedforward control involves phase I to II cross-induction, in which the parent chemical X can also induce phase II enzymes directly through the nuclear receptor and indirectly through transcriptionally upregulating Nrf2. As a result of the active feedforward control, a steady-state hormetic relationship readily arises between the concentrations of the reactive metabolite X' and the extracellular parent chemical X to which the cell is exposed. The shape of dose-response evolves over time from initially monotonically increasing to J-shaped at the final steady state-a temporal sequence consistent with adaptation-mediated hormesis. The magnitude of the hormetic response is enhanced by increases in the feedforward gain, but attenuated by increases in the bioactivation or phase II feedback loop gains. Our study suggests a

  12. Sears Point Tidal Marsh Restoration Project: Phase I

    Science.gov (United States)

    Information about the SFBWQP Sears Point Tidal Marsh Restoration Project: Phase I project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  13. Sensation seeking amongst healthy volunteers participating in phase I clinical trials.

    Science.gov (United States)

    Farré, M; Lamas, X; Camí, J

    1995-01-01

    1. Phase I clinical trials are usually carried out in healthy volunteers. In addition to economic gain, factors that may influence willingness to participate include scientific interest, curiosity and choice for risky activities. 2. We assessed the relationship between personality variables and volunteering for clinical pharmacology research. Two personality questionnaires, the Sensation Seeking Scale (SSS, form V) and the Eysenck Personality Questionnaire (EPQ), were administered to 48 male healthy university students who volunteered to participate in a phase I clinical trial and to 43 male university students who were not willing to participate in phase I clinical trials. General norm data were also used for the comparison of results. 3. When healthy volunteers were compared with unwilling subjects, significant differences were found in thrill-and-adventure seeking (7.9 vs 6.7, P = 0.0034), experience seeking (6.4 vs 5.2, P = 0.0012), disinhibition (6.2 vs 4.3, P personality profile of healthy volunteers was characterized by a higher sensation seeking trait and extraversion as compared with individuals who were not willing to participate in phase I clinical trials and general norm data. PMID:7640147

  14. Final report on Weeks Island Monitoring Phase : 1999 through 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L.; Munson, Darrell Eugene

    2005-05-01

    This Final Report on the Monitoring Phase of the former Weeks Island Strategic Petroleum Reserve crude oil storage facility details the results of five years of monitoring of various surface accessible quantities at the decommissioned facility. The Weeks Island mine was authorized by the State of Louisiana as a Strategic Petroleum Reserve oil storage facility from 1979 until decommissioning of the facility in 1999. Discovery of a sinkhole over the facility in 1992 with freshwater inflow to the facility threatened the integrity of the oil storage and led to the decision to remove the oil, fill the chambers with brine, and decommission the facility. Thereafter, a monitoring phase, by agreement between the Department of Energy and the State, addressed facility stability and environmental concerns. Monitoring of the surface ground water and the brine of the underground chambers from the East Fill Hole produced no evidence of hydrocarbon contamination, which suggests that any unrecovered oil remaining in the underground chambers has been contained. Ever diminishing progression of the initial major sinkhole, and a subsequent minor sinkhole, with time was verification of the response of sinkholes to filling of the facility with brine. Brine filling of the facility ostensively eliminates any further growth or new formation from freshwater inflow. Continued monitoring of sinkhole response, together with continued surface surveillance for environmental problems, confirmed the intended results of brine pressurization. Surface subsidence measurements over the mine continued throughout the monitoring phase. And finally, the outward flow of brine was monitored as a measure of the creep closure of the mine chambers. Results of each of these monitoring activities are presented, with their correlation toward assuring the stability and environmental security of the decommissioned facility. The results suggest that the decommissioning was successful and no contamination of the

  15. Spray Forming Aluminum - Final Report (Phase II)

    Energy Technology Data Exchange (ETDEWEB)

    D. D. Leon

    1999-07-08

    The U.S. Department of Energy - Office of Industrial Technology (DOE) has an objective to increase energy efficient and enhance competitiveness of American metals industries. To support this objective, ALCOA Inc. entered into a cooperative program to develop spray forming technology for aluminum. This Phase II of the DOE Spray Forming Program would translate bench scale spray forming technology into a cost effective world class process for commercialization. Developments under DOE Cooperative Agreement No. DE-FC07-94ID13238 occurred during two time periods due to budgetary constraints; April 1994 through September 1996 and October 1997 and December 1998. During these periods, ALCOA Inc developed a linear spray forming nozzle and specific support processes capable of scale-up for commercial production of aluminum sheet alloy products. Emphasis was given to alloys 3003 and 6111, both being commercially significant alloys used in the automotive industry. The report reviews research performed in the following areas: Nozzel Development, Fabrication, Deposition, Metal Characterization, Computer Simulation and Economics. With the formation of a Holding Company, all intellectual property developed in Phases I and II of the Project have been documented under separate cover for licensing to domestic producers.

  16. Biological applications of phase-contrast electron microscopy.

    Science.gov (United States)

    Nagayama, Kuniaki

    2014-01-01

    Here, I review the principles and applications of phase-contrast electron microscopy using phase plates. First, I develop the principle of phase contrast based on a minimal model of microscopy, introducing a double Fourier-transform process to mathematically formulate the image formation. Next, I explain four phase-contrast (PC) schemes, defocus PC, Zernike PC, Hilbert differential contrast, and schlieren optics, as image-filtering processes in the context of the minimal model, with particular emphases on the Zernike PC and corresponding Zernike phase plates. Finally, I review applications of Zernike PC cryo-electron microscopy to biological systems such as protein molecules, virus particles, and cells, including single-particle analysis to delineate three-dimensional (3D) structures of protein and virus particles and cryo-electron tomography to reconstruct 3D images of complex protein systems and cells.

  17. Single-stage three-phase AC to DC conversion with isolation and Bi-directional power flow

    NARCIS (Netherlands)

    Vermulst, B.J.D.; Duarte, J.L.; Wijnands, C.G.E.; Lomonova, E.A.

    2014-01-01

    An approach for three-phase AC to DC conversion is proposed, which consists of a single-stage while offering galvanic isolation, soft-switching, bi-directional power flow and a significant reduction of inductive and capacitive energy storage. Two elements enable this approach, namely a neutral

  18. 75 FR 32748 - Availability of Testing and Evaluation Report and Intent To Proceed With the Final Stages of...

    Science.gov (United States)

    2010-06-09

    ... of Domain Name System Security Extensions Implementation in the Authoritative Root Zone AGENCY... report and NTIA's intent to proceed with the final stages of DNSSEC deployment in the authoritative root... (ICANN) and VeriSign to deploy DNSSEC at the authoritative root zone of the Internet.\\3\\ Subsequently...

  19. Demonstration Assessment of Light-Emitting Diode (LED) Roadway Lighting, I-35W Bridge, Minneapolis, Minnesota, Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    Kinzey, B. R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Myer, M. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2009-08-01

    On the I-35W Bridge in Minneapolis, Minnesota, the GATEWAY program conducted a two-phase demonstration of LED roadway lighting on the main span, which is one of the country's oldest continuously operated exterior LED lighting installations. The Phase I report provides an overview of initial project results including lighting performance, economic performance, and potential energy savings.

  20. Influence of the selection from incremental stages on lactate minimum intensity: a pilot study

    Directory of Open Access Journals (Sweden)

    Willian Eiji Miyagi

    2013-09-01

    Full Text Available The purposes of this study were to assess the influence of stage selection from the incremental phase and the use of peak lactate after hyperlactatemia induction on the determination of the lactate minimum intensity (iLACmin. Twelve moderately active university students (23±5 years, 78.3±14.1 kg, 175.3±5.1 cm performed a maximal incremental test to determine the respiratory compensation point (RCP (initial intensity at 70 W and increments of 17.5 W every 2 minutes and a lactate minimum test (induction with the Wingate test, the incremental test started at 30 W below RCP with increments of 10 W every 3 minutes on a cycle ergometer. The iLACmin was determined using second order polynomial adjustment applying five exercise stage selection: 1 using all stages (iLACmin P; 2 using all stages below and two stages above iLACminP (iLACminA; 3 using two stages below and all stages above iLACminP (iLACminB; 4 using the largest and same possible number of stages below and above the iLACminP (iLACminI; 5 using all stages and peak lactate after hyperlactatemia induction (iLACminD. No differences were found between the iLACminP (138.2±30.2 W, iLACminA (139.1±29.1 W, iLACminB (135.3±14.2 W, iLACminI (138.6±20.5 W and iLACmiD (136.7±28.5 W protocols, and a high level of agreement between these intensities and iLACminP was observed. Oxygen uptake, heart rate, rating of perceived exertion and lactate corresponding to these intensities was not different and was strongly correlated. However, the iLACminB presented the lowest success rate (66.7%. In conclusion, stage selection did not influence the determination of iLACmin but modified the success rate

  1. Pulse shape discrimination studies of Phase I Ge-detectors

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, Andrea [MPI fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Collaboration: GERDA-Collaboration

    2013-07-01

    The GERmanium Detector Array experiment aims to search for the neutrinoless double beta decay (0νββ) of {sup 76}Ge by using isotopically enriched germanium crystals as source and detector simultaneously. The bare semiconductor diodes are operated in liquid argon at cryogenic temperatures in an ultra-low background environment. In addition, Gerda applies different active background reduction techniques, one of which is pulse shape discrimination studies of the current Phase I germanium detectors. The analysis of the signal time structure provides an important tool to distinguish single site events (SSE) of the ββ-decay from multi site events (MSE) of common gamma-ray background or surface events. To investigate the correlation between the signal shape and the interaction position, a new, also to the predominantly deployed closed-ended coaxial HPGe detectors applicable analysis technique has been developed. A summary of the used electronic/detector assembly is given and followed by a discussion of the performed classification procedure by means of accurate pulse shape simulations of 0νββ-like signals. Finally, the obtained results are presented along with an evaluation of the relevance for the Gerda experiment.

  2. Comparison between surgery and radiofrequency ablation for stage I non-small cell lung cancer

    International Nuclear Information System (INIS)

    Kim, So Ri; Han, Hyo Jin; Park, Seoung Ju; Min, Kyung Hoon; Lee, Min Hee; Chung, Chi Ryang; Kim, Min Ho; Jin, Gong Yong; Lee, Yong Chul

    2012-01-01

    Surgical resection remains as the treatment of choice for non-small cell lung cancer (NSCLC) and provides the best opportunity for cure and long-term survival. Minimally invasive percutaneous ablative therapies, such as radiofrequency ablation (RFA) for treating lung cancers, are currently being studied as treatment alternatives. But, to date, there is little information on comparison of therapeutic effects between surgery and RFA in patients with early stage lung malignancy. We aimed to investigate the clinical significance of RFA as an alternative curative modality for the early stage lung cancer through analyzing the long-term mortality of both treatment groups; surgery vs. RFA. Twenty-two patients of stage I NSCLC were included for this comparative analysis. To minimize confounding effects, we conducted a matching process. In which patients of RFA group (n = 8) were matched with patients of surgery group (n = 14) on the following variables; gender, age (±3 years), tumor node metastasis stage, and calendar year of surgery or RFA (±2 years). The mean survival duration of RFA group and surgery group were 33.18 ± 7.90 and 45.49 ± 7.21, respectively (months, p = 0.297). Log-rank analysis showed that there was no significant difference in overall survival (p = 0.054) between two groups. These results have shown that RFA can offer the survival comparable to that by surgery to stage I NSCLC patients, especially to the patients impossible for the surgery. This study provides an evidence for the use of RFA as a treatment alternative with low procedural morbidity for inoperable early-stage NSCLC patients.

  3. Final work plan : phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Montgomery City, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2010-08-16

    former grain storage facility, the CCC/USDA will conduct investigations to (1) characterize the source(s), extent, and factors controlling the possible subsurface distribution and movement of carbon tetrachloride at the Montgomery City site and (2) evaluate the health and environmental threats potentially represented by the contamination. This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and the MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigations at Montgomery City will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Montgomery City will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Montgomery City investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Montgomery City site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne has issued a Provisional Master Work Plan (PMWP; Argonne 2007) that has been reviewed and approved by the MoDNR for current use. The PMWP (Argonne 2007) provides

  4. Medically inoperable stage I endometrial carcinoma: a few dilemmas in radiotherapeutic management

    International Nuclear Information System (INIS)

    Chao, Clifford K. S.; Grigsby, Perry W.; Perez, Carlos A.; Mutch, David G.; Herzog, Thomas; Camel, H. Marvin

    1996-01-01

    Purpose: The aggressiveness of radiation therapy for patients with medically inoperable endometrial carcinoma is controversial. Patients may die of their underlining medical disease before succumbing to cancer. We try to identify certain subgroup of patients who might benefit most from an aggressive approach and also investigate the impact of residual tumor present in dilatation and curettage (D and C) specimen obtained in second intracavitary implant (ICI). Methods and Materials: From 1965 to 1990, 101 patients were treated for clinical clinical Stage I endometrial carcinoma with RT alone due to medical problems. Ages ranged from 39 to 94 years (median 71 years). There were 18 patients with clinical Stage IA and 83 with clinical Stage IB disease. Histology included 44 well-differentiated, 37 moderately differentiated, and 20 poorly differentiated tumors. Radiation therapy consisted of external beam only in 3 patients, ICI alone in 26, whole pelvis plus ICI in 10, and whole pelvis plus split field plus ICI in 62. A second D and C was performed on 26 patients at the time of the second ICI. Minimum follow-up was 2 years (median, 6.3 years). Results: The 5-year actuarial disease-free survival (DFS) for the studied cohort is comparable to the expected survival of an age-matched population. Pelvic control was 100% for Stage IA and 88% for Stage IB with 5-year disease-free survivals of 80 and 84%, respectively. We also observed a greater disassociation of DFS and overall survival among patients older than 75 years (84 and 55%, respectively) than in younger patients (84 and 78%, respectively). This is mainly because older patients succumbed to their medical illness. Well-differentiated disease demonstrated the trend toward a better outcome than moderately or poorly differentiated lesions in Stage IB patients (p 0.05), but not in Stage IA patients. Aggressive radiation therapy approach showed the trend toward a better result in Stage IB patients 75 years of age or younger

  5. Pre-defined and optional staging for the deployment of enterprise systems: a case study and a framework

    Science.gov (United States)

    Lichtenstein, Yossi; Cucuy, Shy; Fink, Lior

    2017-03-01

    The effective deployment of enterprise systems has been a major challenge for many organisations. Customising the new system, changing business processes, and integrating multiple information sources are all difficult tasks. As such, they are typically done in carefully planned stages in a process known as phased implementation. Using ideas from Option Theory, this article critiques aspects of phased implementation. One customer relationship management (CRM) project and its phased implementation are described in detail and ten other enterprise system deployments are summarised as a basis for the observation that almost all deployment stages are pre-defined operational steps rather than decision points. However, Option Theory suggests that optional stages, to be used only when risk materialises, should be integral parts of project plans. Although such optional stages are often more valuable than pre-defined stages, the evidence presented in this article shows that they are only rarely utilised. Therefore, a simple framework is presented; it first identifies risks related to the deployment of enterprise systems, then identifies optional stages that can mitigate these risks, and finally compares the costs and benefits of both pre-defined and optional stages.

  6. Treatment results of radiotherapy for medically inoperable stage I/II non-small cell lung cancer

    International Nuclear Information System (INIS)

    Zhang Li; Wang Lvhua; Zhang Hongxing; Chen Dongfu; Xiao Zefen; Wang Mei; Feng Qinfu; Liang Jun; Zhou Zongmei; Ou Guangfei; Lv Jima; Yin Weibo

    2008-01-01

    Objective: To retrospectively analyze treatment results of radiotherapy for medically inoperable stage I/II non-small cell lung cancer. Methods: Between Jan. 2000 and Dec. 2005, fifty-eight such patients were enrolled into the database analysis, including 37 with clinical stage I and 21 with stage II disease. Fifty patients received radiotherapy alone and eight with radiotherapy and chemotherapy. Forty- three patients were treated with 3-D conformal radiotherapy (3D-CRT) and 15 with conventional radiotherapy. Results: The 1-, 2- and 3-year overall survival rates were 85%, 54% and 30%, and the median survival time was 26.2 months for the whole group. The corresponding figures were 88%, 60%, 36% and 30.8 months for cancer-specific survival; 84%, 64%, 31% and 30.8 months for Stage I disease; 81%, 47%, 28% and 18.8 months for Stage II disease; 95%, 57%, 33% and 30.8 months for 3D-CRT group and 53%, 44%, 24% and 15.3 months for conventional radiotherapy group. By logrank test, tumor volume, pneumonitis of Grade II or higher and weight loss more than 5% showed statistically significant impact on overall survival. Tumor volume was the only independent prognostic factor in Cox multivariable regression. Pneumonitis and esophagitis of Grade II or higher were 16% and 2%, respectively. Age and lung function before treatment had a significant relationship with pneumonitis. Failure included the local recurrence (33%) and distant metastasis (21%). There was no difference between the treatment modalities and failure sites. Conclusions: For medically inoperable early stage non-small cell lung cancer patients, tumor volume is the most important prognostic factor for overall survival. The conformal radiotherapy marginally improves the survival. The age and pulmonary function are related to the incidence of treatment induced pneumonitis. (authors)

  7. KNK I Test Program, Final Report Part 1

    International Nuclear Information System (INIS)

    Kathol, W.

    1976-01-01

    The compact sodium cooled nuclear reactor KNK I of the Karlsruhe Research Center reached full power for the first time in February 1974. The goal of KNK I is to collect experience for the construction and operation of larger reactors, such as SNR 300. In order to deepen these experiences, a test program was drawn up and conducted from 1973 until 1975 within the framework of R and D work on the development of fast breeder reactors. The program included individual tasks concerning reactor design, safety instrumentation, irradiation and post-examination as well as behavior of components during operation. The performance of the tests was essentially governed by the licensing procedure imposed under the atomic energy act for the construction and operation of nuclear facilities. This report is the first part of the final report of the test program

  8. Development of a coal fired pulse combustor for residential space heating. Phase I, Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-04-01

    This report presents the results of the first phase of a program for the development of a coal-fired residential combustion system. This phase consisted of the design, fabrication, testing, and evaluation of an advanced pulse combustor sized for residential space heating requirements. The objective was to develop an advanced pulse coal combustor at the {approximately} 100,000 Btu/hr scale that can be integrated into a packaged space heating system for small residential applications. The strategy for the development effort included the scale down of the feasibility unit from 1-2 MMBtu/hr to 100,000 Btu/hr to establish a baseline for isolating the effect of scale-down and new chamber configurations separately. Initial focus at the residential scale was concentrated on methods of fuel injection and atomization in a bare metal unit. This was followed by incorporating changes to the advanced chamber designs and testing of refractory-lined units. Multi-fuel capability for firing oil or gas as a secondary fuel was also established. Upon completion of the configuration and component testing, an optimum configuration would be selected for integrated testing of the pulse combustor unit. The strategy also defined the use of Dry Ultrafine Coal (DUC) for Phases 1 and 2 of the development program with CWM firing to be a product improvement activity for a later phase of the program.

  9. Comparison of Pelvic Phased-Array versus Endorectal Coil Magnetic Resonance Imaging at 3 Tesla for Local Staging of Prostate Cancer

    OpenAIRE

    Kim, Bum Soo; Kim, Tae-Hwan; Kwon, Tae Gyun; Yoo, Eun Sang

    2012-01-01

    Purpose Several studies have demonstrated the superiority of endorectal coil magnetic resonance imaging (MRI) over pelvic phased-array coil MRI at 1.5 Tesla for local staging of prostate cancer. However, few have studied which evaluation is more accurate at 3 Tesla MRI. In this study, we compared the accuracy of local staging of prostate cancer using pelvic phased-array coil or endorectal coil MRI at 3 Tesla. Materials and Methods Between January 2005 and May 2010, 151 patients underwent radi...

  10. Cosmological Constant and the Final Anthropic Hypothesis

    OpenAIRE

    Cirkovic, Milan M.; Bostrom, Nick

    1999-01-01

    The influence of recent detections of a finite vacuum energy ("cosmological constant") on our formulation of anthropic conjectures, particularly the so-called Final Anthropic Principle is investigated. It is shown that non-zero vacuum energy implies the onset of a quasi-exponential expansion of our causally connected domain ("the universe") at some point in the future, a stage similar to the inflationary expansion at the very beginning of time. The transition to this future inflationary phase...

  11. A review of single-phase grid-connected inverters for photovoltaic modules

    DEFF Research Database (Denmark)

    Kjaer, Soren Baekhoej; Pedersen, John Kim; Blaabjerg, Frede

    2005-01-01

    -phase grid; 3) whether they utilizes a transformer (either line or high frequency) or not; and 4) the type of grid-connected power stage. Various inverter topologies are presented, compared, and evaluated against demands, lifetime, component ratings, and cost. Finally, some of the topologies are pointed out......This review focuses on inverter technologies for connecting photovoltaic (PV) modules to a single-phase grid. The inverters are categorized into four classifications: 1) the number of power processing stages in cascade; 2) the type of power decoupling between the PV module(s) and the single...

  12. Characterisation of GERDA Phase-I detectors in liquid argon

    Energy Technology Data Exchange (ETDEWEB)

    Barnabe Heider, Marik; Schoenert, Stefan [Max-Planck-Institut fuer Kernphysik (Germany); Gusev, Konstantin [Russian Research Center, Kurchatov Institute (Russian Federation); Joint Institute for Nuclear Research (Russian Federation)

    2009-07-01

    GERDA will search for neutrinoless double beta decay in {sup 76}Ge by submerging bare enriched HPGe detectors in liquid argon. In GERDA Phase-I, reprocessed enriched-Ge detectors, which were previously operated by the Heidelberg-Moscow and IGEX collaborations, and reprocessed natural-Ge detectors from Genius-TF, will be redeployed. We have tested the operation and performance of bare HPGe detectors in liquid nitrogen and in liquid argon over more than three years with three non-enriched p-type prototype detectors. The detector handling and mounting procedures have been defined and the Phase-I detector technology, the low-mass assembly and the long-term stability in liquid argon have been tested successfully. The Phase-I detectors were reprocessed by Canberra Semiconductor NV, Olen, according to their standard technology but without the evaporation of a passivation layer. After their reprocessing, the detectors have been mounted in their low-mass holders and their characterisation in liquid argon performed. The leakage current, the counting characteristics and the efficiency of the detectors have been measured. The testing of the detectors was carried out in the liquid argon test stand of the GERDA underground Detector Laboratory (GDL) at LNGS. The detectors are now stored underground under vacuum until their operation in GERDA.

  13. Phase I Source Investigation, Heckathorn Superfund Site, Richmond, California

    Energy Technology Data Exchange (ETDEWEB)

    Kohn, Nancy P; Evans, Nathan R

    2002-12-18

    This report represents Phase I of a multi-phase approach to a source investigation of DDT at the Heckathorn Superfund Site, Richmond, California, the former site of a pesticide packaging plant, and the adjacent waterway, the Lauritzen Channel. Potential identified sources of contamination were from sloughed material from undredged areas (such as side banks) and from outfall pipes. Objectives of Phase I included the (1) evaluation of pesticide concentrations associated with discharge from outfalls, (2) identification of additional outfalls in the area, (3) identification of type, quantity, and distribution of sediment under the Levin pier, (4) quantification of pesticide concentrations in sediment under the pier, and (5) evaluation of sediment structure and slope stability under the pier. Field operations included the collection of sediment directly from inside the mouths of outfall pipes, when possible, or the deployment of specially designed particle traps where direct sampling was problematic. Passive water samplers were placed at the end of known outfall pipes and analyzed for DDT and other pesticides of concern. Underwater dive surveys were conducted beneath the Levin pier to document type, slope, and thickness of sediment. Samples were collected at locations of interest and analyzed for contaminants. Also sampled was soil from bank areas, which were suspected of potentially contributing to continued DDT contamination of the Lauritzen Channel through erosion and groundwater leaching. The Phase I Source Investigation was successful in identifying significant sources of DDT contamination to Lauritzen Channel sediment. Undredged sediment beneath the Levin pier that has been redistributed to the channel is a likely source. Two outfalls tested bear further investigation. Not as well-defined are the contributions of bank erosional material and groundwater leaching. Subsequent investigations will be based on the results of this first phase.

  14. Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - A first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study

    International Nuclear Information System (INIS)

    Baumann, Pia; Nyman, Jan; Hoyer, Morten; Gagliardi, Giovanna; Lax, Ingmar; Wennberg, Berit; Drugge, Ninni; Ekberg, Lars; Friesland, Signe; Johansson, Karl-Axel; Lund, Jo-Asmund; Morhed, Elisabeth; Nilsson, Kristina; Levin, Nina; Paludan, Merete; Sederholm, Christer; Traberg, Anders; Wittgren, Lena; Lewensohn, Rolf

    2008-01-01

    Background and Aims: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15 Gy x 3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). Material and methods: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45 Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. Results: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. Conclusion: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity

  15. Environmentally benign manufacturing of compact disc stampers[Final Phase II report]; FINAL

    International Nuclear Information System (INIS)

    None

    1999-01-01

    Optical data storage is currently a$10B/yr. business. With the introduction of the high capacity Digital Versatile Disc (D/D) as well as the continued growth of CD-Audio and CD-ROM worldwide sales of optical data products as a whole are growing at rate of more than 10% per year. In North America, more than 2.5 billion optical discs will be sold in 1998. By 1999, the numbers of optical discs produced for the North American market will grow to almost three billion. The optical disc manufacturing industry is dominated by Asian and European companies (e.g. Sony of Japan and Philips of Netherlands). Prism Corporation has created a process that could significantly improve US competitiveness in the business of optical disc production. The objectives of the Phase II STTR project were to build and test an ion machining system (IMS) for stamper fabrication, prove overall manufacturing system feasibility by fabrication stampers and replicas, and evaluate alternative materials and alternative process parameters to optimize the process. During tie period of the Phase II project Prism Corporation was able to meet these objectives. In the course of doing so, adjustments had been made to better the project and in turn the final product. An ion machining system was designed and built that produced stampers ready for the molding process. Also, many control steps in the manufacturing process were studied to improve the current process and make it even more compatible with the industry standards, fitting seamlessly into current manufacturing lines

  16. Adaptive nonlinear control of single-phase to three-phase UPS system

    Directory of Open Access Journals (Sweden)

    Kissaoui M.

    2014-01-01

    Full Text Available This work deals with the problems of uninterruptible power supplies (UPS based on the single-phase to three-phase converters built in two stages: an input bridge rectifier and an output three phase inverter. The two blocks are joined by a continuous intermediate bus. The objective of control is threefold: i power factor correction “PFC”, ii generating a symmetrical three-phase system at the output even if the load is unknown, iii regulating the DC bus voltage. The synthesis of controllers has been reached by two nonlinear techniques that are the sliding mode and adaptive backstepping control. The performances of regulators have been validated by numerical simulation in MATLAB / SIMULINK.

  17. Shape Memory Alloy-Based Periodic Cellular Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort will develop and demonstrate an innovative shape memory alloy (SMA) periodic cellular structural technology. Periodic cellular structures...

  18. Gradiometer Based on Nonlinear Magneto-Optic Rotation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR project will demonstrate sensitive measurements of magnetic field gradients by nonlinear atomic spectroscopy. The gradients are determined by...

  19. Integrated monitoring and surveillance system demonstration project: Phase I accomplishments

    International Nuclear Information System (INIS)

    Aumeier, S.E.; Walters, B.G.; Crawford, D.C.

    1997-01-01

    The authors present the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase I efforts. The rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include decisions to use Echelon LonWorks networking protocol and Microsoft Access for the data system needs, a preliminary design for the plutonium canning system glovebox, identification of facilities and materials available for the demonstration, determination of possibly affected facility documentation, and a preliminary list of available sensor technologies. Recently imposed changes in the overall project schedule and scope are also discussed and budgetary requirements for competition of Phase II presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase I deliverables

  20. BWR Full Integral Simulation Test (FIST). Phase I test results

    International Nuclear Information System (INIS)

    Hwang, W.S.; Alamgir, M.; Sutherland, W.A.

    1984-09-01

    A new full height BWR system simulator has been built under the Full-Integral-Simulation-Test (FIST) program to investigate the system responses to various transients. The test program consists of two test phases. This report provides a summary, discussions, highlights and conclusions of the FIST Phase I tests. Eight matrix tests were conducted in the FIST Phase I. These tests have investigated the large break, small break and steamline break LOCA's, as well as natural circulation and power transients. Results and governing phenomena of each test have been evaluated and discussed in detail in this report. One of the FIST program objectives is to assess the TRAC code by comparisons with test data. Two pretest predictions made with TRACB02 are presented and compared with test data in this report

  1. Precipitation and Deposition of Aluminum-Containing Phases in Tank Wastes. Final Report

    International Nuclear Information System (INIS)

    Dabbs, Daniel M.; Aksay, Ilhan A.

    2009-01-01

    maintaining silicon-containing particles under high pH conditions but at smaller size with respect to standard suspensions of silicon-containing particles. In the final stage of our study, the emphasis shifted to the inhibition of corrosion using surfactants. The model system selected consisted of copper thin films on gold substrates. An optical microscopy technique was developed for measuring corrosion kinetics under low pH (∼3). As long as color variations are not affected by the formation of adlayers (reaction products) on the anode, our method can be used as a powerful quantitative tool for measuring corrosion rates with high spatial and temporal resolution in microscopic model systems, and is not limited to copper-gold systems. Further measurements on technically relevant systems, such as aluminum, could not be made before the project was ended.

  2. 77 FR 9655 - Mobility Fund Phase I Auction Updated List of Potentially Eligible Census Blocks

    Science.gov (United States)

    2012-02-17

    ... FEDERAL COMMUNICATIONS COMMISSION [AU Docket No. 12-25; DA 12-187] Mobility Fund Phase I Auction.... DATES: Pursuant to the Auction 901 (Mobility Fund Phase I) Comment Public Notice, 77 FR 7152, February... 9, 2012. ADDRESSES: Pursuant to the Auction 901 (Mobility Fund Phase I) Comment Public Notice, 77 FR...

  3. Distributed Engine Control Empirical/Analytical Verification Tools, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase I project, Impact Technologies, in collaboration with Prof. R.K. Yedavalli, propose a novel verification environment for eventual rapid certification...

  4. High Performance Low Mass Nanowire Enabled Heatpipe, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Illuminex Corporation proposes a NASA Phase I SBIR project to develop high performance, lightweight, low-profile heat pipes with enhanced thermal transfer properties...

  5. Cognitive impairment is associated with Hoehn and Yahr stages in early, de novo Parkinson disease patients.

    Science.gov (United States)

    Siciliano, Mattia; De Micco, Rosa; Trojano, Luigi; De Stefano, Manuela; Baiano, Chiara; Passaniti, Carla; De Mase, Antonio; Russo, Antonio; Tedeschi, Gioacchino; Tessitore, Alessandro

    2017-08-01

    The relationship between motor impairment and cognitive deterioration has long been described in Parkinson's disease (PD). The aim of the study was to compare cognitive performance of de novo PD patients in relation to the motor impairment severity according to Hoehn and Yahr (HY) stages. Forty de novo PD patients at HY stage I and 40 patients at HY stage II completed a standardized neuropsychological battery. A multivariate analysis of covariance was used to compare cognitive performance between HY groups. Odds ratios (ORs) were employed to explore the risk of cognitive impairment between HY stages. Finally, the prevalence of mild cognitive impairment (MCI) was estimated for patients in HY stage I and II. Patients at HY stage I obtained better scores on neuropsychological tests than patients at HY stage II (p = 0.001). Univariate analysis of covariance revealed significant differences between HY stages on Rey's auditory verbal learning test -immediate recall (p cognitive impairment were greater for HY stage II than stage I group. MCI occurred in 7.5% of patients in HY stage I, and in 42.5% of patients in HY stage II. In de novo PD patients, the severity of motor impairment at the diagnosis is associated to cognitive deficits and higher risk of MCI. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Airborne electronically steerable phased array

    Science.gov (United States)

    1972-01-01

    The results are presented of the second stage of a program for the design and development of a phased array capable of simultaneous and separate transmission and reception of radio frequency signals at S-band frequencies. The design goals of this stage were the development of three major areas of interest required for the final prototype model. These areas are the construction and testing of the low-weight, full-scale 128-element array of antenna elements, the development of the RF manifold feed system, and the construction and testing of a working module containing diplexer and transmit and receive circuits.

  7. Novel Techniques with the Aid of a Staged CBCT Guided Surgical Protocol

    Directory of Open Access Journals (Sweden)

    Evdokia Chasioti

    2015-01-01

    Full Text Available The case report will present some novel techniques for using a “staged” protocol utilizing strategic periodontally involved teeth as transitional abutments in combination with CBCT guided implant surgery. Staging the case prevented premature loading of the grafted sites during the healing phase. A CBCT following a tenting screw guided bone regeneration procedure ensured adequate bone to place an implant fixture. Proper assessment of the CBCT allowed the surgeon to do an osteotome internal sinus lift in an optimum location. The depth of the bone needed for the osteotome sinus floor elevation was planned. The staged appliance allowed these sinus-augmented sites to heal for an extended period of time compared to implants, which were uncovered and loaded at an earlier time frame. The staged protocol and CBCT analysis enabled the immediate implants to be placed in proper alignment to the adjacent fixture. After teeth were extracted, the osseointegrated implants were converted to abutments for the transitional appliance. Finally, the staged protocol allowed for soft tissue enhancement in the implant and pontic areas prior to final insertion of the prosthesis.

  8. FACTORS INFLUENCING THE ACCURACY OF PRE-CONTRACT STAGE ESTIMATION OF FINAL CONTRACT PRICE IN NEW ZEALAND

    Directory of Open Access Journals (Sweden)

    Cong Ji

    2014-12-01

    Full Text Available Establishing and prioritising the factors that may influence the final contract price when responding to a call for tenders is crucial for proper risk analysis and reliable forecasting; it could make or mar the ability to achieve expected profit margin in an era of lump sum fixed price contracts where clients often contest variation claims. In New Zealand, these factors have not been researched; hence estimators rely only on judgement to ‘guess-estimate’ in their price forecasting. This study aimed to fill the knowledge gap by investigating the priority factors. 150 responses from professional members of the New Zealand Institute of Quantity Surveyors were analysed using multi-attribute method. Results showed thirty-seven factors which could influence the final contract price; the three most influential being poor tender documentation, complexity of design & construction, and completeness of project information. Other factors relating to project, client and contractor characteristics, design consultants and tendering conditions, estimating practice and external factors were reported. Concordance analysis indicated high level of agreement amongst survey participants in the rank-ordering of the relative importance of the identified factors. The findings could assist quantity surveyors to prepare more reliable contract price estimates at the pre-contract stage. It would also improve construction-stage cost control.

  9. GMP production and characterization of leucine zipper-tagged tumor necrosis factor-related apoptosis-inducing ligand (LZ-TRAIL) for phase I clinical trial.

    Science.gov (United States)

    Jiang, Jing; Liu, Xiaobin; Deng, Leixiu; Zhang, Peipei; Wang, Guangjun; Wang, Shifu; Liu, Honghao; Su, Yunpeng

    2014-10-05

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits potent antitumor activity in a wide range of cancers without deleterious side effects on normal tissues. Several TRAIL derivatives have been developed to improve its pharmacokinetics and therapeutic effects through strategies such as adding a leucine zipper to increase the circulation half-life. To obtain clinical grade LZ-TRAIL for phase I clinical trial, a single batch of 30 L bioreactor culture was performed using the Escherichia coli BL21 (DE3) strain expressing the recombinant LZ-TRAIL. A robust LZ-TRAIL production fermentation process was developed, which could be scaled up from 5L to 50 L, and had a titer of approximately 1.4 g/l. A four-step purification strategy was carried out to obtain a final product with over 95% purity and 45% yield. The final material was filter sterilized, aseptically vialed, and stored at 4°C, and comprehensively characterized using multiple assays (vialed product was sterile, purity was 95%, aggregates were production of phase I clinical trial material. These preclinical investigations warrant further clinical development of this product for cancer therapy. Copyright © 2014. Published by Elsevier B.V.

  10. Real-time Multispecies Spacecraft Air Quality Monitor, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase I proposal seeks to develop an ultrasensitive, multispecies sensor system for use in determining the efficacy of air...

  11. Joining Silicon Carbide Components for Space Propulsion, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I program will identify the joining materials and demonstrate the processes that are suited for construction of advanced ceramic matrix composite...

  12. Multi-channel tunable source for atomic sensors, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR will establish the feasibility of developing compact, robust, integrated components suitable for atomic interferometry. AdvR's design is enabled by...

  13. Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials

    International Nuclear Information System (INIS)

    Young, R.C.; Walton, L.A.; Ellenberg, S.S.; Homesley, H.D.; Wilbanks, G.D.; Decker, D.G.; Miller, A.; Park, R.; Major, F. Jr.

    1990-01-01

    About a third of patients with ovarian cancer present with localized disease; despite surgical resection, up to half the tumors recur. Since it has not been established whether adjuvant treatment can benefit such patients, we conducted two prospective, randomized national cooperative trials of adjuvant therapy in patients with localized ovarian carcinoma. All patients underwent surgical resection plus comprehensive staging and, 18 months later, surgical re-exploration. In the first trial, 81 patients with well-differentiated or moderately well differentiated cancers confined to the ovaries (Stages Iai and Ibi) were assigned to receive either no chemotherapy or melphalan (0.2 mg per kilogram of body weight per day for five days, repeated every four to six weeks for up to 12 cycles). After a median follow-up of more than six years, there were no significant differences between the patients given no chemotherapy and those treated with melphalan with respect to either five-year disease-free survival or overall survival. In the second trial, 141 patients with poorly differentiated Stage I tumors or with cancer outside the ovaries but limited to the pelvis (Stage II) were randomly assigned to treatment with either melphalan (in the same regimen as above) or a single intraperitoneal dose of 32P (15 mCi) at the time of surgery. In this trial (median follow-up, greater than 6 years) the outcomes for the two treatment groups were similar with respect to five-year disease-free survival (80 percent in both groups) and overall survival (81 percent with melphalan vs. 78 percent with 32P; P = 0.48). We conclude that in patients with localized ovarian cancer, comprehensive staging at the time of surgical resection can serve to identify those patients (as defined by the first trial) who can be followed without adjuvant chemotherapy

  14. Evaluation of mercury in liquid waste processing facilities - Phase I report

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Site (SRS), Aiken, SC (United States); Occhipinti, J. E. [Savannah River Site (SRS), Aiken, SC (United States); Shah, H. [Savannah River Site (SRS), Aiken, SC (United States); Wilmarth, W. R. [Savannah River Site (SRS), Aiken, SC (United States); Edwards, R. E. [Savannah River Site (SRS), Aiken, SC (United States)

    2015-07-01

    This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.

  15. Evaluation of Mercury in Liquid Waste Processing Facilities - Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Site (SRS), Aiken, SC (United States); Occhipinti, J. [Savannah River Site (SRS), Aiken, SC (United States); Shah, H. [Savannah River Site (SRS), Aiken, SC (United States); Wilmarth, B. [Savannah River Site (SRS), Aiken, SC (United States); Edwards, R. [Savannah River Site (SRS), Aiken, SC (United States)

    2015-07-01

    This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.

  16. Axillary radiotherapy in conservative surgery for early-stage breast cancer (stage I and II).

    Science.gov (United States)

    García Novoa, Alejandra; Acea Nebril, Benigno; Díaz, Inma; Builes Ramírez, Sergio; Varela, Cristina; Cereijo, Carmen; Mosquera Oses, Joaquín; López Calviño, Beatriz; Seoane Pillado, María Teresa

    2016-01-01

    Several clinical studies analyze axillary treatment in women with early-stage breast cancer because of changes in the indication for axillary lymph node dissection. The aim of the study is to analyze the impact of axillary radiotherapy in disease-free and overall survival in women with early breast cancer treated with lumpectomy. Retrospective study in women with initial stages of breast carcinoma treated by lumpectomy. A comparative analysis of high-risk women with axillary lymph node involvement who received axillary radiotherapy with the group of women with low risk without radiotherapy was performed. Logistic regression was used to determine factors influencing survival and lymphedema onset. A total of 541 women were included in the study: 384 patients (71%) without axillary lymph node involvement and 157 women (29%) with 1-3 axillary lymph node involvement. Patients with axillary radiotherapy had a higher number of metastatic lymph node compared to non-irradiated (1.6±0.7 vs. 1.4±0.6, P=.02). The group of women with axillary lymph node involvement and radiotherapy showed an overall and disease-free survival at 10 years similar to that obtained in patients without irradiation (89.7% and 77.2%, respectively). 3 lymph nodes involved multiplied by more than 7 times the risk of death (HR=7.20; 95% CI: 1.36 to 38.12). The multivariate analysis showed axillary lymph node dissection as the only variable associated with the development of lymphedema. The incidence of axillary relapse on stage I and II breast cancer is rare. In these patients axillary radiotherapy does not improve overall survival, but contributes to regional control in those patients with risk factors. Copyright © 2016 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer

    International Nuclear Information System (INIS)

    Zhao, Hanxi; Xie, Peng; Li, Xiaolin; Zhu, Wanqi; Sun, Xindong; Sun, Xiaorong; Chen, Xiaoting; Xing, Ligang; Yu, Jinming

    2015-01-01

    Background: Acute radiation-induced esophagitis (ARIE) is one of main toxicities complicated by thoracic radiotherapy, influencing patients’ quality of life and radiotherapy proceeding seriously. It is difficult to be cured rapidly so far. Our phase I trial preliminarily showed that EGCG may be a promising strategy in the treatment of ARIE. Materials and methods: We prospectively enrolled patients with stage III lung cancer from the Shandong Tumor Hospital & Institute in China from January 2013 to September 2014. All patients received concurrent or sequential chemo-radiotherapy, or radiotherapy only. EGCG was administrated once ARIE appeared. EGCG was given with the concentration of 440 μmol/L during radiotherapy and additionally two weeks after radiotherapy. RTOG score, dysphagia and pain related to esophagitis were recorded every week. Results: Thirty-seven patients with stage IIIA and IIIB lung cancer were enrolled in this trial. In comparison to the original, the RTOG score in the 1st, 2nd, 3rd, 4th, 5th week after EGCG prescription and the 1st, 2nd week after radiotherapy decreased significantly (P = 0.002, 0.000, 0.000, 0.001, 0.102, 0.000, 0.000, respectively). The pain score of each week was significantly lower than the baseline (P = 0.000, 0.000, 0.000, 0.000, 0.006, 0.000, 0.000, respectively). Conclusion: This trial confirmed that the oral administration of EGCG is an effective and safe method to deal with ARIE. A phase III randomized controlled trial is expected to further corroborate the consequence of EGCG in ARIE treatment

  18. Postoperative high dose rate vaginal apex brachytherapy in stage I endometrial adenocarcinoma

    International Nuclear Information System (INIS)

    Turner, B.; Knisely, J.; Kacinski, B.; Roberts, K.; Peschel, R.; Gumbs, A.; Rutherford, T.; Edraki, B.; Schwartz, P.; Chambers, J.; Kohorn, E.; Wilson, L.

    1996-01-01

    Introduction: Patients with stage I endometrial adenocarcinoma have traditionally been treated with TAH/BSO and radiation. The reported incidence of local recurrence in surgically treated patients with Figo stage IA or IB endometrial adenocarcinoma is 4-10% at 2 years. Combined surgery and radiation has resulted in a reduction of recurrence to 2-6%. We report the presentation, local and distant control, salvage rate, survival and complications for patients undergoing high dose rate (HDR) vaginal apex brachytherapy following surgery. Methods: Between 1985 and 1994 a total of 302 patients with Figo stage I endometrial carcinoma were treated with HDR Ir-192 vaginal apex brachytherapy to a total dose of 21 Gy in 3 fractions at 0.5 cm from the vaginal mucosa. The pathologic stage by treatment group was IA: 31%, IB: 68%, and IC: 1%. The histologic grade of the patient's tumors was grade 1: 69%, 2: 27%, and 3: 4%. The median time from surgery to radiation was 33 days (range 14-66 days). The median follow-up for 300 patients with stage IA (91 patients), IB (205 patients), and IC (4 patients) was respectively 36, 34 and 40 months (2 patients lost to follow-up prior to 6 months). Results: Patients presented with vaginal bleeding (94%) or abnormal pap smear (6%) at a median age for stage IA and IB, of 55 and 64 years, respectively. The crude overall survival of the patient population at 2 years is 95%. Median overall time to failure is 19.5 months (range 10-36 months). The overall failure rate was 2.7% (8 patients), local failure only 1.0% (38% of failed group), distant failure only 0.3% (12% of failed group) and combined local/distant failure 1.3% (50% of failed group). The local failure rate for pathologic stage IA patients was 1.0% and no distant disease was observed. The local failure rate for pathologic stage IB patients was 3.4% 7/205 and distant failure was 2.4% 5/205. The majority of patients with recurrence had grade 2 histologic changes 5/8. The overall salvage rate

  19. RFI mitigating receiver back end for radiometers, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I proposal requests support for Alphacore, Inc. to design and a low power application specific integrated circuit (ASIC) RFI mitigating receiver back...

  20. Kinetic boundaries and phase transformations of ice i at high pressure

    Science.gov (United States)

    Wang, Yu; Zhang, Huichao; Yang, Xue; Jiang, Shuqing; Goncharov, Alexander F.

    2018-01-01

    Raman spectroscopy in diamond anvil cells has been employed to study phase boundaries and transformation kinetics of H2O ice at high pressures up to 16 GPa and temperatures down to 15 K. Ice i formed at nearly isobaric cooling of liquid water transforms on compression to high-density amorphous (HDA) ice at 1.1-3 GPa at 15-100 K and then crystallizes in ice vii with the frozen-in disorder (ice vii') which remains stable up to 14.1 GPa at 80 K and 15.9 GPa at 100 K. Unexpectedly, on decompression of ice vii', it transforms to ice viii in its domain of metastability, and then it relaxes into low-density amorphous (LDA) ice on a subsequent pressure release and warming up. On compression of ice i at 150-170 K, ice ix is crystallized and no HDA ice is found; further compression of ice ix results in the sequential phase transitions to stable ices vi and viii. Cooling ice i to 210 K at 0.3 GPa transforms it to a stable ice ii. Our extensive investigations provide previously missing information on the phase diagram of water, especially on the kinetic paths that result in formation of phases which otherwise are not accessible; these results are keys for understanding the phase relations including the formation of metastable phases. Our observations inform on the ice modifications that can occur naturally in planetary environments and are not accessible for direct observations.

  1. Urban Integrated Industrial Cogeneration Systems Analysis. Phase II final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Through the Urban Integrated Industrial Cogeneration Systems Analysis (UIICSA), the City of Chicago embarked upon an ambitious effort to identify the measure the overall industrial cogeneration market in the city and to evaluate in detail the most promising market opportunities. This report discusses the background of the work completed during Phase II of the UIICSA and presents the results of economic feasibility studies conducted for three potential cogeneration sites in Chicago. Phase II focused on the feasibility of cogeneration at the three most promising sites: the Stockyards and Calumet industrial areas, and the Ford City commercial/industrial complex. Each feasibility case study considered the energy load requirements of the existing facilities at the site and the potential for attracting and serving new growth in the area. Alternative fuels and technologies, and ownership and financing options were also incorporated into the case studies. Finally, site specific considerations such as development incentives, zoning and building code restrictions and environmental requirements were investigated.

  2. Componentized Models as a Service (CMaaS), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research (SBIR) Phase I project, which will conclude with a Technical Readiness Level of 3-4, will demonstrate the feasibility of the...

  3. Higher Strength, Lighter Weight Aluminum Spacecraft Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I program proposes to develop a bulk processing technology for producing ultra fine grain (UFG) aluminum alloy structures. The goal is to demonstrate...

  4. Simulating Nonlinear Dynamics of Deployable Space Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — To support NASA's vital interest in developing much larger solar array structures over the next 20 years, MotionPort LLC's Phase I SBIR project will strengthen...

  5. LENA Conversion Foils Using Single-Layer Graphene, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Our key innovation will be the use of single-layer graphene as LENA conversion foils, with appropriate microgrids and nanogrids to support the foils. Phase I...

  6. Micromachined High-Temperature Sensors for Planet Exploration, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In phase I of the SBIR program, LEEOAT Company will develop, simulate, fabricate and test high-temperature piezoelectric miniature sensors (up to 800oC), for...

  7. Development of a high temperature solar powered water chiller. Volume 3. Phase I technical progress report, September 26, 1977--June 1, 1978

    Energy Technology Data Exchange (ETDEWEB)

    English, R. A.

    1978-06-01

    This section describes the conceptual design rationale and resulting design configuration as well as providing estimates of cost and performance. Because the development of the turbo-compressor design paralleled the development of the chiller system design, all of the cost and performance data are based on intermediate turbo-compressor performance data, as well as on unoptimized components. Optimized performance was computed at the very end of Phase I, and only a brief comparison is made to show the potential gains available. Updating of all the predicted performance data for the final conceptual design will await Phase II.

  8. Phase I North Central Cancer Treatment Group Trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer

    International Nuclear Information System (INIS)

    Garces, Yolanda I.; Okuno, Scott H.; Schild, Steven E.; Mandrekar, Sumithra J.; Bot, Brian M.; Martens, John M.; Wender, Donald B.; Soori, Gamini S.; Moore, Dennis F.; Kozelsky, Timothy F.; Jett, James R.

    2007-01-01

    Purpose: The primary goal was to identify the maximum tolerable dose (MTD) of thoracic radiation therapy (TRT) that can be given with chemotherapy and amifostine for patients with limited-stage small-cell lung cancer (LSCLC). Methods and Materials: Treatment began with two cycles of topotecan (1 mg/m 2 ) Days 1 to 5 and paclitaxel (175 mg/m 2 ) Day 5 (every 3 weeks) given before and after TRT. The TRT began at 6 weeks. The TRT was given in 120 cGy fractions b.i.d. and the dose escalation (from 4,800 cGy, dose level 1, to 6,600 cGy, dose level 4) followed the standard 'cohorts of 3' design. The etoposide (E) (50 mg/day) and cisplatin (C) (3 mg/m 2 ) were given i.v. before the morning TRT and amifostine (500 mg/day) was given before the afternoon RT. This was followed by prophylactic cranial irradiation (PCI). The dose-limiting toxicities (DLTs) were defined as Grade ≥4 hematologic, febrile neutropenia, esophagitis, or other nonhematologic toxicity, Grade ≥3 dyspnea, or Grade ≥2 pneumonitis. Results: Fifteen patients were evaluable for the Phase I portion of the trial. No DLTs were seen at dose levels 1 and 2. Two patients on dose level 4 experienced DLTs: 1 patient had a Grade 4 pneumonitis, dyspnea, fatigue, hypokalemia, and anorexia, and 1 patient had a Grade 5 hypoxia attributable to TRT. One of 6 patients on dose level 3 had a DLT, Grade 3 esophagitis. The Grade ≥3 toxicities seen in at least 10% of patients during TRT were esophagitis (53%), leukopenia (33%), dehydration (20%), neutropenia (13%), and fatigue (13%). The median survival was 14.5 months. Conclusion: The MTD of b.i.d. TRT was 6000 cGy (120 cGy b.i.d.) with EP and amifostine

  9. CP-violating Majorana phases, lepton-conserving processes, and final state interactions

    International Nuclear Information System (INIS)

    Nieves, Jose F.; Pal, Palash B.

    2003-01-01

    The CP-violating phases associated with Majorana neutrinos can give rise to CP-violating effects even in processes that conserve total lepton number, such as μ→eee-bar, μe→ee, and others. After explaining the reasons that make this happen, we consider the calculation of the rates for a process of the form l a l b →l a l c and its conjugate l-bar a l-bar b →l-bar a l-bar c , where l a ,l b ,l c denote charged leptons of different flavors. In the context of the standard model with Majorana neutrinos, we show that the difference in the rates depends on such phases. Our calculations illustrate in detail the mechanics that operate behind the scene, and set the stage for carrying out the analogous, more complicated (as we explain) calculations for other processes such as μ→eee-bar and its conjugate

  10. Stable and metastable phases in reciprocal systems PbSe + Ag2I2 Ag2Se + PbI2 and PbSe + CdI2 = CdSe + PbI2

    International Nuclear Information System (INIS)

    Odin, I.N.; Grin'ko, V.V.; Kozlovskij, V.F.; Safronov, E.V.

    2005-01-01

    Mutual system PbSe + Ag 2 I 2 = Ag 2 Se + PbI 2 is investigated. It is shown that diagonal Ag 2 Se-PbI 2 is stable. Liquidus surface and isothermal section at 633 K of phase diagram of PbSe-Ag 2 Se-PbI 2 system are built. Transformations directing to crystallization metastable ternary compound forming in PbSe-PbI 2 system and metastable polytype modifications of lead iodide in PbSe-Ag 2 Se-PbI 2 system at 620-685 K are studied. By hardening from molten state (1150-1220 K) new interstitial metastable phases crystallizing in CdCl 2 structural type are obtained in PbSe-Ag 2 Se-PbI 2 and PbSe + CdI 2 = CdSe + PbI 2 systems [ru

  11. Thermodynamic phase transition of a black hole in rainbow gravity

    Directory of Open Access Journals (Sweden)

    Zhong-Wen Feng

    2017-09-01

    Full Text Available In this letter, using the rainbow functions that were proposed by Magueijo and Smolin, we investigate the thermodynamics and the phase transition of rainbow Schwarzschild black hole. First, we calculate the rainbow gravity corrected Hawking temperature. From this modification, we then derive the local temperature, free energy, and other thermodynamic quantities in an isothermal cavity. Finally, we analyze the critical behavior, thermodynamic stability, and phase transition of the rainbow Schwarzschild black hole. The results show that the rainbow gravity can stop the Hawking radiation in the final stages of black holes' evolution and lead to the remnants of black holes. Furthermore, one can observe that the rainbow Schwarzschild black hole has one first-order phase transition, two second-order phase transitions, and three Hawking–Page-type phase transitions in the framework of rainbow gravity theory.

  12. Bulk Nano-structured Materials for Turbomachinery Components, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort seeks to exploit some of the tremendous benefits that could be attained from a revolutionary new approach to grain refinement in bulk...

  13. Foamed Antenna Support for Very Large Apertures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed Phase I program will demonstrate the feasibility of the in-space production of large aperture antenna structures. The use of a novel open cell foam,...

  14. Treatment outcome after adjuvant radiotherapy following surgery for patients with stage I endometrial cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji Young; Lee, Kyung Ja; Park, Kyung Ran [Dept. of Radiation Oncology, Ewha Womans University School of Medicine, Seoul (Korea, Republic of); and others

    2016-12-15

    The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma. The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who underwent adjuvant radiotherapy following surgery between March 2000 and April 2014. Of these, 25 received postoperative VB alone, while 18 received postoperative EBRT to the whole pelvis; 3 of these were treated with EBRT plus VB. The median EBRT dose was 50.0 Gy (45.0–50.4 Gy) and the VB dose was 24 Gy in 6 fractions. Tumor dose was prescribed at a depth of 5 mm from the cylinder surface and delivered twice per week. The median follow-up period for all patients was 57 months (range, 9 to 188 months). Five-year disease-free survival (DFS) and overall survival (OS) for all patients were 92.5% and 95.3%, respectively. Adjuvant radiotherapy was performed according to risk factors and stage IB, grade 3 and lymphovascular invasion were observed more frequently in the EBRT group. Five-year DFS for EBRT and VB alone were 88.1% and 96.0%, respectively (p = 0.42), and 5-year OS for EBRT and VB alone were 94.4% and 96%, respectively (p = 0.38). There was no locoregional recurrence in any patient. Two patients who received EBRT and 1 patient who received VB alone developed distant metastatic disease. Two patients who received EBRT had severe complications, one each of grade 3 gastrointestinal complication and pelvic bone insufficiency fracture. Adjuvant radiotherapy achieved high DFS and OS with acceptable toxicity in stage I endometrial cancer. VB (with a lower dose per fraction) may be a viable option for selected patients with early-stage endometrial cancer following surgery.

  15. One-stage and two-stage penile buccal mucosa urethroplasty

    Directory of Open Access Journals (Sweden)

    G. Barbagli

    2016-03-01

    Full Text Available The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa graft with the application of glue is preliminary showed and discussed. Two-stage penile urethroplasty is then reported. A detailed description of first-stage urethroplasty according Johanson technique is reported. A second-stage urethroplasty using buccal mucosa graft and glue is presented. Finally postoperative course and follow-up are addressed.

  16. Breast-conserving therapy (BCT) in stage I-II synchronous bilateral breast cancer (SBBC)

    Energy Technology Data Exchange (ETDEWEB)

    Gollamudi, Smitha V; Gelman, Rebecca S; Peiro, Gloria; Schneider, Lindsey; Connolly, James L; Schnitt, Stuart; Silver, Barbara; Harris, Jay R

    1995-07-01

    PURPOSE: To determine whether patients with early-stage SBBC can be safely and effectively treated with bilateral BCT. MATERIALS and METHODS: We retrospectively reviewed records of 26 patients with clinical Stage I-II SBBC treated between 1968-1989 with bilateral BCT. SBBC was defined as tumors diagnosed no more than one month apart, with both sides demonstrating invasive cancer. Maximum (max) clinical stage was based on the more advanced breast tumor. Median age at diagnosis was 56 years (range, 32-85 years); menopausal status was 6 pre-, 16 post-, 3 peri-, and 1 unknown at diagnosis. Median follow-up for surviving pts is 95 months (range, 68-157). Outcome was compared to 1325 pts with unilateral Stage I or II breast cancer, within the same age range, treated during the same time period. There were no significant differences in median age, median total dose, tumor size, estrogen receptor (ER) status, pathologic nodal status, and use of systemic therapy between the study population and the comparison group. Local recurrence (LR) was evaluated as true recurrence (TR, i.e., in the original tumor bed), marginal miss (MM, at the edge of the boost field), or elsewhere (E). Median total dose to the primary was 6100 cGy (range, 5000-7000). Pathology was available for review in 19 cases. Cytology (nuclear and cytoplasmic features) was similar in (7(19)) evaluable cases, and architecture (growth pattern, ie, papillary, solid) was similar in (5(19)) cases. The presence of either cytologic or architectural similarity was noted in(9(19)) cases. 7 of 19 pts who had axillary lymph node evaluation on at least one side had pathological confirmation of lymph node metastasis. Stage was the same in both breasts in 13 cases (10 Stage I, 3 Stage II); ER status data was complete in 11 pts, and the same in both primaries in 9 cases. Cosmetic results and complications after BCT were scored. Statistical significance was evaluated by use of the Fisher exact test. RESULTS: The 5-yr actuarial

  17. Close set in volleyball. Differences and discriminatory power of final game actions in formative stages

    Directory of Open Access Journals (Sweden)

    Dávila Romero, Carlos

    2012-01-01

    Full Text Available The aim of this study was to establish which final game actions discriminate final victories and defeats in women volleyball formative stages during ended sets, which are solved by regulation with a minimal advantage of two points. A total of 57 sets were analyzed in infantile category and 69 sets in cadet category during the national volleyball championship at school age (12-16, Valladolid 2008 and Huelva 2009. Statistics analysis shows differences between the condition of both the winner and the loser teams in sets in the positive attack in infantile category and in positive block and error in cadet category. Discriminative analysis, statistical test that determines those most significant game actions when establishing the differences existing between the winner and loser teams, shows how to predict victory and defeat in the ended sets regarding the positive attack, negative service and error in infantile category and positive block and error in cadet category. These ones suggest that during decisive set moments in both categories, either technical gestures control or errors which arise from a regulation infraction may predict their final performance.

  18. Outcomes of Risk-Adapted Fractionated Stereotactic Radiotherapy for Stage I Non-Small-Cell Lung Cancer

    International Nuclear Information System (INIS)

    Lagerwaard, Frank J.; Haasbeek, Cornelis J.A.; Smit, Egbert F.; Slotman, Ben J.; Senan, S.

    2008-01-01

    Purpose: High local control rates can be achieved using stereotactic radiotherapy in Stage I non-small-cell lung cancer (NSCLC), but reports have suggested that toxicity may be of concern. We evaluated early clinical outcomes of 'risk-adapted' fractionation schemes in patients treated in a single institution. Methods and Materials: Of 206 patients with Stage I NSCLC, 81% were unfit to undergo surgery and the rest refused surgery. Pathologic confirmation of malignancy was obtained in 31% of patients. All other patients had new or growing 18F-fluorodeoxyglucose positron emission tomography positive lesions with radiologic characteristics of malignancy. Planning four-dimensional computed tomography scans were performed and fractionation schemes used (3 x 20 Gy, 5 x 12 Gy, and 8 x 7.5 Gy) were determined by T stage and risk of normal tissue toxicity. Results: Median overall survival was 34 months, with 1- and 2-year survivals of 81% and 64%, respectively. Disease-free survival (DFS) at 1 and 2 years was 83% and 68%, respectively, and DFS correlated with T stage (p = 0.002). Local failure was observed in 7 patients (3%). The crude regional failure rate was 9%; isolated regional recurrence was observed in 4%. The distant progression-free survival at 1 and 2 years was 85% and 77%, respectively. SRT was well tolerated and severe late toxicity was observed in less than 3% of patients. Conclusions: SRT is well tolerated in patients with extensive comorbidity with high local control rates and minimal toxicity. Early outcomes are not inferior to those reported for conventional radiotherapy. In view of patient convenience, such risk-adapted SRT schedules should be considered treatment of choice in patients presenting with medically inoperable Stage I NSCLC

  19. 77 FR 38803 - Mobility Fund Phase I Auction Updated Data For Auction 901

    Science.gov (United States)

    2012-06-29

    ... FEDERAL COMMUNICATIONS COMMISSION [AU Docket No. 12-25; DA 12-990] Mobility Fund Phase I Auction... files of census blocks eligible for the Mobility Fund Phase I support to be offered in Auction 901... 32092, May 31, 2012, the Bureaus described how they identified census blocks eligible for the Mobility...

  20. Gastrointestinal morbidity of adjuvant radiotherapy in stage I malignant teratoma of the testis

    International Nuclear Information System (INIS)

    Hamilton, C.R.; Horwich, A.; Peckham, M.J.; Bliss, J.M.

    1987-01-01

    Between January 1963 and December 1983, 248 patients with stage I teratoma were managed by the Testicular Tumour Unit of the Royal Marsden Hospital (RMH). Before 1979, these patients were treated with adjuvant irradiation to the abdominal and pelvic lymph nodes (142 patients) to a mid-plane dose of 40 Gy in 20 fractions over 4 weeks. In 1979, a surveillance policy was adopted (106 patients) and relapsing patients treated with chemotherapy. By 2 years post-orchidectomy, seven patients (4.9%) in the irradiated group developed duodenal ulceration compared to none in the surveillance group (p = 0.05). A past medical history of duodenal ulcer was a significant risk factor for ulceration after radiotherapy (p = 0.04) whereas a past history of abdominal surgery was not (p = 0.8). It is concluded that adjuvant radiotherapy for stage I teratoma may increase the risk of peptic ulceration. 14 refs.; 1 figure; 4 tabs

  1. L1CAM in Early-Stage Type I Endometrial Cancer: Results of a Large Multicenter Evaluation

    NARCIS (Netherlands)

    Zeimet, A.G.; Reimer, D.; Huszar, M.; Winterhoff, B.; Puistola, U.; Azim, S.A.; Muller-Holzner, E.; Ben-Arie, A.; Kempen, L.C.L.T. van; Petru, E.; Jahn, S.; Geels, Y.P.; Massuger, L.F.A.G.; Amant, F.; Polterauer, S.; Lappi-Blanco, E.; Bulten, J.; Meuter, A.; Tanouye, S.; Oppelt, P.; Stroh-Weigert, M.; Reinthaller, A.; Mariani, A.; Hackl, W.; Netzer, M.; Schirmer, U.; Vergote, I.; Altevogt, P.; Marth, C.; Fogel, M.

    2013-01-01

    BACKGROUND: Despite the excellent prognosis of Federation Internationale de Gynecologie et d'Obstetrique (FIGO) stage I, type I endometrial cancers, a substantial number of patients experience recurrence and die from this disease. We analyzed the value of immunohistochemical L1CAM determination to

  2. Live Imaging of Meiosis I in Late-Stage Drosophila melanogaster Oocytes.

    Science.gov (United States)

    Hughes, Stacie E; Hawley, R Scott

    2017-01-01

    Drosophila melanogaster has been studied for a century as a genetic model to understand recombination, chromosome segregation, and the basic rules of inheritance. However, it has only been about 25 years since the events that occur during nuclear envelope breakdown, spindle assembly, and chromosome orientation during D. melanogaster female meiosis I were first visualized by fixed cytological methods (Theurkauf and Hawley, J Cell Biol 116:1167-1180, 1992). Although these fixed cytological studies revealed many important details about the events that occur during meiosis I, they failed to elucidate the timing or order of these events. The development of protocols for live imaging of meiotic events within the oocyte has enabled collection of real-time information on the kinetics and dynamics of spindle assembly, as well as the behavior of chromosomes during prometaphase I. Here, we describe a method to visualize spindle assembly and chromosome movement during meiosis I by injecting fluorescent dyes to label microtubules and DNA into stage 12-14 oocytes. This method enables the events during Drosophila female meiosis I, such as spindle assembly and chromosome movement, to be observed in vivo, regardless of genetic background, with exceptional spatial and temporal resolution.

  3. Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease.

    Science.gov (United States)

    Bazzigaluppi, Paolo; Beckett, Tina L; Koletar, Margaret M; Lai, Aaron Y; Joo, Illsung L; Brown, Mary E; Carlen, Peter L; McLaurin, JoAnne; Stefanovic, Bojana

    2018-03-01

    Alzheimer's disease (AD) is pathologically characterized by amyloid-β peptide (Aβ) accumulation, neurofibrillary tangle formation, and neurodegeneration. Preclinical studies on neuronal impairments associated with progressive amyloidosis have demonstrated some Aβ-dependent neuronal dysfunction including modulation of gamma-aminobutyric acid-ergic signaling. The present work focuses on the early stage of disease progression and uses TgF344-AD rats that recapitulate a broad repertoire of AD-like pathologies to investigate the neuronal network functioning using simultaneous intracranial recordings from the hippocampus (HPC) and the medial prefrontal cortex (mPFC), followed by pathological analyses of gamma-aminobutyric acid (GABA A ) receptor subunits α1 , α5, and δ, and glutamic acid decarboxylases (GAD65 and GAD67). Concomitant to amyloid deposition and tau hyperphosphorylation, low-gamma band power was strongly attenuated in the HPC and mPFC of TgF344-AD rats in comparison to those in non-transgenic littermates. In addition, the phase-amplitude coupling of the neuronal networks in both areas was impaired, evidenced by decreased modulation of theta band phase on gamma band amplitude in TgF344-AD animals. Finally, the gamma coherence between HPC and mPFC was attenuated as well. These results demonstrate significant neuronal network dysfunction at an early stage of AD-like pathology. This network dysfunction precedes the onset of cognitive deficits and is likely driven by Aβ and tau pathologies. This article is part of the Special Issue "Vascular Dementia". © 2017 Her Majesty the Queen in Right of Canada Journal of Neurochemistry © 2017 International Society for Neurochemistry.

  4. Evaporation dynamics of a sessile droplet on glass surfaces with fluoropolymer coatings: focusing on the final stage of thin droplet evaporation.

    Science.gov (United States)

    Gatapova, Elizaveta Ya; Shonina, Anna M; Safonov, Alexey I; Sulyaeva, Veronica S; Kabov, Oleg A

    2018-03-07

    The evaporation dynamics of a water droplet with an initial volume of 2 μl from glass surfaces with fluoropolymer coatings are investigated using the shadow technique and an optical microscope. The droplet profile for a contact angle of less than 5° is constructed using an image-analyzing interference technique, and evaporation dynamics are investigated at the final stage. We coated the glass slides with a thin film of a fluoropolymer by the hot-wire chemical vapor deposition method at different deposition modes depending on the deposition pressure and the temperature of the activating wire. The resulting surfaces have different structures affecting the wetting properties. Droplet evaporation from a constant contact radius mode in the early stage of evaporation was found followed by the mode where both contact angle and contact radius simultaneously vary in time (final stage) regardless of wettability of the coated surfaces. We found that depinning occurs at small contact angles of 2.2-4.7° for all samples, which are smaller than the measured receding contact angles. This is explained by imbibition of the liquid into the developed surface of the "soft" coating that leads to formation of thin droplets completely wetting the surface. The final stage, which is little discussed in the literature, is also recorded. We have singled out a substage where the contact line velocity is abruptly increasing for all coated and uncoated surfaces. The critical droplet height corresponding to the transition to this substage is about 2 μm with R/h = 107. The duration of this substage is the same for all coated and uncoated surfaces. Droplets observed at this substage for all the tested surfaces are axisymmetric. The specific evaporation rate clearly demonstrates an abrupt increase at the final substage of the droplet evaporation. The classical R 2 law is justified for the complete wetting situation where the droplet is disappearing in an axisymmetric manner.

  5. Combined chemo-radiation therapy to adult patients with B-cell lymphoma in stage I and II

    International Nuclear Information System (INIS)

    Shimoyama, Masanori

    1988-01-01

    155 adult patients with B-lymphoma in stage I and II who were treated in National Cancer Center Hospital between 1975 and 1986 were analyzed for treatment outcome. 5-year survival rates were about 66 % in these patients and almost equal in the patients treated with radiation alone, doxorubicin-containing combination chemotherapy alone, or combined chemoradiation therapy. However, when analysis was limited to patients in stage I, patients treated with chemotherapy alone seemed to have better survival rate than those treated with radiation alone. In the patients who were in stage III or more and had bulky mass more than 10 cm in diameter, small residual tumor was sometimes detected by restaging procedure after achieving apparent remission by multi-drug chemotherapy. In these patients, additional radiation therapy was quite usefull to eradicate residual tumor cell to cure. (author)

  6. Salvage of relapse of patients with Hodgkin's disease in clinical stages I or II who were staged with laparotomy and initially treated with radiotherapy alone. A report from the international database on Hodgkin's disease

    DEFF Research Database (Denmark)

    Specht, L.; Horwich, A.; Ashley, S.

    1994-01-01

    patients in the International Database on Hodgkin's Disease who were initially in clinical Stages I or II, who were staged with laparotomy, and who relapsed after initial treatment with irradiation alone. Factors analyzed for outcome after first relapse included initial stage, age, sex, histology......PURPOSE: To analyze presentation variables that might indicate a high or low likelihood of success of the treatment of patients relapsing after initial radiotherapy of Hodgkin's disease in clinical Stages I or II who were staged with laparotomy. METHODS AND MATERIALS: Data were analyzed on 681...

  7. Microfluidic System for CO2 Reduction to Hydrocarbons in Microgravity, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In the combined Phase I and Phase II programs Faraday and our MIT collaborators will demonstrate the feasibility of low-cost fabrication of high-efficiency,...

  8. Process integration and waste heat recovery in Lithuanian and Danish industry. Final report phase 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-08-01

    The present document forms the Final Report for the first phase of the project `Process Integration and Waste Heat Recovery in Lithuanian and Danish Industry`. The project is carried out in the period 1995-1998 in a co-operation between the COWI offices in Lyngby and Vilnius, The Technical University of Denmark (Institute for Energetics), Kaunas University of Technology (CIPAI) and Vilnius Technical University, financed by The Danish Ministry of Energy`s EFP-95-programme, Lithuanian Energy Agency as well as the participants. The first phase of the project has comprised the establishment of the CIPAI centre (Centre for Industrial Process Analysis and Integration) at Kaunas University of Technology, training and knowledge transfer as well as elaboration of 6 industrial case-studies within the area of `Process Integration and waste Heat Recovery`. The second phase of the project has comprised R and D activities in this area in order to present general conclusions from the project as well as to present new and improved methods and tools for PI-analysis. The aim of the Final Report for the first phase of the project is to summarise project activities and the achieved results from case-studies and from the operation of the CIPAI-centre in general. (au)

  9. Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

    Directory of Open Access Journals (Sweden)

    van der Meijde Jolanda

    2007-08-01

    Full Text Available Abstract Background Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARα may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR. Results After 24 hours of fasting, expression levels of 33 of the 253 analyzed transporter and phase I/II metabolism genes were changed. Upregulated genes were involved in transport of energy-yielding molecules in processes such as glycogenolysis (G6pt1 and mitochondrial and peroxisomal oxidation of fatty acids (Cact, Mrs3/4, Fatp2, Cyp4a10, Cyp4b1. Other induced genes were responsible for the inactivation of the neurotransmitter serotonin (Sert, Sult1d1, Dtd, Papst2, formation of eicosanoids (Cyp2j6, Cyp4a10, Cyp4b1, or for secretion of cholesterol (Abca1 and Abcg8. Cyp3a11, typically known because of its drug metabolizing capacity, was also increased. Fasting had no pronounced effect on expression of phase II metabolic enzymes, except for glutathione S-transferases which were down-regulated. Time course studies revealed that some genes were acutely regulated, whereas expression of other genes was only affected after prolonged fasting. Finally, we identified 8 genes that were PPARα-dependently upregulated upon fasting. Conclusion We have characterized the response to fasting on expression of transporters and phase I/II metabolic enzymes in murine small intestine. Differentially expressed genes are involved in a variety of processes, which functionally can be summarized as a increased oxidation of fat and xenobiotics, b increased cholesterol secretion, c increased susceptibility to electrophilic stressors, and d reduced intestinal motility. This knowledge increases our understanding of gut physiology, and may be of relevance

  10. Waste area Grouping 2 Phase I remedial investigation: Sediment and Cesium-137 transport modeling report

    International Nuclear Information System (INIS)

    Clapp, R.B.; Bao, Y.S.; Moore, T.D.; Brenkert, A.L.; Purucker, S.T.; Reece, D.K.; Burgoa, B.B.

    1996-06-01

    This report is one of five reports issued in 1996 that provide follow-up information to the Phase I Remedial Investigation (RI) Report for Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL). The five reports address areas of concern that may present immediate risk to public health at the Clinch River and ecological risk within WAG 2 at ORNL. A sixth report, on groundwater, in the series documenting WAG 2 RI Phase I results were part of project activities conducted in FY 1996. The five reports that complete activities conducted as part of Phase I of the Remedial Investigation (RI) for WAG 2 are as follows: (1) Waste Area Grouping 2, Phase I Task Data Report: Seep Data Assessment, (2) Waste Area Grouping 2, Phase I Task Data Report: Tributaries Data Assessment, (3) Waste Area Grouping 2, Phase I Task Data Report: Ecological Risk Assessment, (4) Waste Area Grouping 2, Phase I Task Data Report: Human Health Risk Assessment, (5) Waste Area Grouping 2, Phase I Task Data Report: Sediment and 137 Cs Transport Modeling In December 1990, the Remedial Investigation Plan for Waste Area Grouping 2 at Oak Ridge National Laboratory was issued (ORNL 1990). The WAG 2 RI Plan was structured with a short-term component to be conducted while upgradient WAGs are investigated and remediated, and a long-term component that will complete the RI process for WAG 2 following remediation of upgradient WAGs. RI activities for the short-term component were initiated with the approval of the Environmental Protection Agency, Region IV (EPA), and the Tennessee Department of Environment and Conservation (TDEC). This report presents the results of an investigation of the risk associated with possible future releases of 137 Cs due to an extreme flood. The results are based on field measurements made during storms and computer model simulations

  11. The effects of solar Reimers η on the final destinies of Venus, the Earth, and Mars

    Science.gov (United States)

    Guo, Jianpo; Lin, Ling; Bai, Chunyan; Liu, Jinzhong

    2016-04-01

    Our Sun will lose sizable mass and expand enormously when it evolves to the red giant branch phase and the asymptotic giant branch phase. The loss of solar mass will push a planet outward. On the contrary, solar expansion will enhance tidal effects, and tidal force will drive a planet inward. Will our Sun finally engulf Venus, the Earth, and Mars? In the literature, one can find a large number of studies with different points of view. A key factor is that we do not know how much mass the Sun will lose at the late stages. The Reimers η can describe the efficiency of stellar mass-loss and greatly affect solar mass and solar radius at the late stages. In this work, we study how the final destinies of Venus, the Earth, and Mars can be depending on Reimers η chosen. In our calculation, the Reimers η varies from 0.00 to 0.75, with the minimum interval 0.0025. Our results show that Venus will be engulfed by the Sun and Mars will most probably survive finally. The fate of the Earth is uncertain. The Earth will finally be engulfed by the Sun while η <0.4600, and it will finally survive while η ≥ 0.4600. New observations indicate that the average Reimers η for solar-like stars is 0.477. This implies that Earth may survive finally.

  12. Joint Carrier-Phase Synchronization and LDPC Decoding

    Science.gov (United States)

    Simon, Marvin; Valles, Esteban

    2009-01-01

    A method has been proposed to increase the degree of synchronization of a radio receiver with the phase of a suppressed carrier signal modulated with a binary- phase-shift-keying (BPSK) or quaternary- phase-shift-keying (QPSK) signal representing a low-density parity-check (LDPC) code. This method is an extended version of the method described in Using LDPC Code Constraints to Aid Recovery of Symbol Timing (NPO-43112), NASA Tech Briefs, Vol. 32, No. 10 (October 2008), page 54. Both methods and the receiver architectures in which they would be implemented belong to a class of timing- recovery methods and corresponding receiver architectures characterized as pilotless in that they do not require transmission and reception of pilot signals. The proposed method calls for the use of what is known in the art as soft decision feedback to remove the modulation from a replica of the incoming signal prior to feeding this replica to a phase-locked loop (PLL) or other carrier-tracking stage in the receiver. Soft decision feedback refers to suitably processed versions of intermediate results of iterative computations involved in the LDPC decoding process. Unlike a related prior method in which hard decision feedback (the final sequence of decoded symbols) is used to remove the modulation, the proposed method does not require estimation of the decoder error probability. In a basic digital implementation of the proposed method, the incoming signal (having carrier phase theta theta (sub c) plus noise would first be converted to inphase (I) and quadrature (Q) baseband signals by mixing it with I and Q signals at the carrier frequency [wc/(2 pi)] generated by a local oscillator. The resulting demodulated signals would be processed through one-symbol-period integrate and- dump filters, the outputs of which would be sampled and held, then multiplied by a soft-decision version of the baseband modulated signal. The resulting I and Q products consist of terms proportional to the cosine

  13. Evaluation of the AJCC 8th Edition Staging System for Pathologically Versus Clinically Staged Intrahepatic Cholangiocarcinoma (iCCA): a Time to Revisit a Dogma? A Surveillance, Epidemiology, and End Results (SEER) Analysis.

    Science.gov (United States)

    Kamarajah, Sivesh K

    2018-03-07

    Recently, the AJCC has released its 8th edition changes to the staging system for intrahepatic cholangiocarcinoma (iCCA). This study sought to validate the proposed changes to the 8th edition of AJCC system for T and N classification of iCCA using a population-based data set. Using the Surveillance, Epidemiology, and End Results (SEER) database (1998-2013), patients undergoing resection or non-surgical management for non-metastatic iCCA were identified. Overall survival was estimated using the Kaplan-Meier method and compared using log-rank tests. Concordance indices (c-indices) calculated from Cox proportional hazards models were calculated to evaluate discriminatory power. The study included 2630 patients resected (37%) or non-surgically managed (63%) for iCCA. Nodal staging was performed in 56%, of whom 31% had positive nodes. For all patients with iCCA, the median 5-year survival by AJCC T classification for T1a, T1b, T2, T3, and T4 was 32, 21, 14, 10, and 10 months, respectively (p < 0.001). The concordance index for the staging system was 0.57 for all patients, 0.62 for those who underwent resection, and 0.54 for patients who did not undergo resection. In summary, the new AJCC 8th edition staging system is comparable to the 7th edition and valid in stratifying patients with iCCA. However, the performance of the staging system is better in patients undergoing surgical resection than those undergoing non-surgical management. These findings further highlight the need for improved accuracy of radiological imaging in clinically staging patients to guide prognosis.

  14. iROLL: does 3-D radioguided occult lesion localization improve surgical management in early-stage breast cancer?

    Energy Technology Data Exchange (ETDEWEB)

    Bluemel, Christina; Kajdi, Georg W.; Schmid, Jan; Buck, Andreas K.; Herrmann, Ken [University Hospital of Wuerzburg, Department of Nuclear Medicine, Wuerzburg (Germany); Cramer, Andreas; Grossmann, Christoph; Grimminger, Hanns-Joerg [Missionsaerztliches Klinikum Wuerzburg, Department of Obstetrics and Gynecology, Wuerzburg (Germany); Malzahn, Uwe [University of Wuerzburg, Institute of Clinical Epidemiology and Biometry, Wuerzburg (Germany); Lamp, Nora [University of Wuerzburg, Institute of Pathology, Wuerzburg (Germany); Langen, Heinz-Jakob [Missionsaerztliches Klinikum Wuerzburg, Department of Radiology, Wuerzburg (Germany)

    2015-10-15

    To prospectively evaluate the feasibility of 3-D radioguided occult lesion localization (iROLL) and to compare iROLL with wire-guided localization (WGL) in patients with early-stage breast cancer undergoing breast-conserving surgery and sentinel lymph node biopsy (SLNB). WGL (standard procedure) and iROLL in combination with SLNB were performed in 31 women (mean age 65.1 ± 11.2 years) with early-stage breast cancer and clinically negative axillae. Patient comfort in respect of both methods was assessed using a ten point scale. SLNB and iROLL were guided by freehand SPECT (fhSPECT). The results of the novel 3-D image-based method were compared with those of WGL, ultrasound-based lesion localization, and histopathology. iROLL successfully detected the malignant primary and at least one sentinel lymph node in 97 % of patients. In a single patient (3 %), only iROLL, and not WGL, enabled lesion localization. The variability between fhSPECT and ultrasound-based depth localization of breast lesions was low (1.2 ± 1.4 mm). Clear margins were achieved in 81 % of the patients; however, precise prediction of clear histopathological surgical margins was not feasible using iROLL. Patients rated iROLL as less painful than WGL with a pain score 0.8 ± 1.2 points (p < 0.01) lower than the score for iROLL. iROLL is a well-tolerated and feasible technique for localizing early-stage breast cancer in the course of breast-conserving surgery, and is a suitable replacement for WGL. As a single image-based procedure for localization of breast lesions and sentinel nodes, iROLL may improve the entire surgical procedure. However, no advantages of the image-guided procedure were found with regard to prediction of complete tumour resection. (orig.)

  15. Low Energy Nuclear Reaction Aircraft- 2013 ARMD Seedling Fund Phase I Project

    Science.gov (United States)

    Wells, Douglas P.; McDonald, Robert; Campbell, Robbie; Chase, Adam; Daniel, Jason; Darling, Michael; Green, Clayton; MacGregor, Collin; Sudak, Peter; Sykes, Harrison; hide

    2014-01-01

    This report serves as the final written documentation for the Aeronautic Research Mission Directorate (ARMD) Seedling Fund's Low Energy Nuclear Reaction (LENR) Aircraft Phase I project. The findings presented include propulsion system concepts, synergistic missions, and aircraft concepts. LENR is a form of nuclear energy that potentially has over 4,000 times the energy density of chemical energy sources. It is not expected to have any harmful emissions or radiation which makes it extremely appealing. There is a lot of interest in LENR, but there are no proven theories. This report does not explore the feasibility of LENR. Instead, it assumes that a working system is available. A design space exploration shows that LENR can enable long range and high speed missions. Six propulsion concepts, six missions, and four aircraft concepts are presented. This report also includes discussion of several issues and concerns that were uncovered during the study and potential research areas to infuse LENR aircraft into NASA's aeronautics research.

  16. Phase multistability in a dynamical small world network

    Energy Technology Data Exchange (ETDEWEB)

    Shabunin, A. V., E-mail: shabuninav@info.sgu.ru [Radiophysics and Nonlinear Dynamics Department, Saratov State University, Saratov (Russian Federation)

    2015-01-15

    The effect of phase multistability is explored in a small world network of periodic oscillators with diffusive couplings. The structure of the network represents a ring with additional non-local links, which spontaneously arise and vanish between arbitrary nodes. The dynamics of random couplings is modeled by “birth” and “death” stochastic processes by means of the cellular automate approach. The evolution of the network under gradual increasing of the number of random couplings goes through stages of phases fluctuations and spatial cluster formation. Finally, in the presence of non-local couplings the phase multistability “dies” and only the in-phase regime survives.

  17. A Detector for Combined SPECT/CT. Final Technical Report

    International Nuclear Information System (INIS)

    Vivek Nagarkar

    2006-01-01

    The goal of the Phase I research was to demonstrate the feasibility of developing a high performance SPECT/CT detector module based on a combination of microcolumnar CsI(Tl) scintillator coupled to an EMCCD readout. We are very pleased to report that our Phase I research has demonstrated the technical feasibility of our approach with a very high degree of success. Specifically, we were able to implement a back-thinned EMCCD with a fiberoptic window which was successfully used to demonstrate the feasibility of near simultaneous radionuclide/CT using the proposed concept. Although significantly limited in imaging area (24 x 24 mm 2 ) and pixel resolution (512 x 512), this prototype has shown exceptional capabilities such as a single optical photon sensitivity, very low noise, an intrinsic resolution of 64 (micro)m for radionuclide imaging, and a resolution in excess of 10 lp/mm for x-ray imaging. Furthermore, the combination of newly developed, thick, microcolumnar CsI and an EMCCD has shown to be capable of operating in a photon counting mode, and that the position and energy information obtained from these data can be used to improve resolution in radionuclide imaging. Finally, the prototype system has successfully been employed for near simultaneous SPECT/CT imaging using both, 125 I and 99m Tc radioisotopes. The tomographic reconstruction data obtained using a mouse heart phantom and other phantoms clearly demonstrate the feasibility and efficacy of the detector in small animal research. The following were the objectives specified in the Phase I proposal: (1) In consultation with Professor Hasegawa, develop specifications for the Phase I/Phase II prototype detector; (2) Modify current vapor deposition protocols to fabricate ∼2 mm thick microcolumnar CsI(Tl) scintillators with excellent columnar structure, high light yield, and high spatial resolution; (3) Perform detailed characterization of the film morphology, light output, and spatial resolution, and use

  18. Final Report on Two-Stage Fast Spectrum Fuel Cycle Options

    International Nuclear Information System (INIS)

    Yang, Won Sik; Lin, C. S.; Hader, J. S.; Park, T. K.; Deng, P.; Yang, G.; Jung, Y. S.; Kim, T. K.; Stauff, N. E.

    2016-01-01

    This report presents the performance characteristics of two ''two-stage'' fast spectrum fuel cycle options proposed to enhance uranium resource utilization and to reduce nuclear waste generation. One is a two-stage fast spectrum fuel cycle option of continuous recycle of plutonium (Pu) in a fast reactor (FR) and subsequent burning of minor actinides (MAs) in an accelerator-driven system (ADS). The first stage is a sodium-cooled FR fuel cycle starting with low-enriched uranium (LEU) fuel; at the equilibrium cycle, the FR is operated using the recovered Pu and natural uranium without supporting LEU. Pu and uranium (U) are co-extracted from the discharged fuel and recycled in the first stage, and the recovered MAs are sent to the second stage. The second stage is a sodium-cooled ADS in which MAs are burned in an inert matrix fuel form. The discharged fuel of ADS is reprocessed, and all the recovered heavy metals (HMs) are recycled into the ADS. The other is a two-stage FR/ADS fuel cycle option with MA targets loaded in the FR. The recovered MAs are not directly sent to ADS, but partially incinerated in the FR in order to reduce the amount of MAs to be sent to the ADS. This is a heterogeneous recycling option of transuranic (TRU) elements

  19. Solar central receiver hybrid power system. Phase I study

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-11-01

    A management plan is presented for implementation during the Solar Central Receiver Hybrid Power System - Phase I study project. The project plan and the management controls that will be used to assure technically adequate, timely and cost effective performance of the work required to prepare the designated end products are described. Bechtel in-house controls and those to be used in directing the subcontractors are described. Phase I of the project consists of tradeoff studies, parametric analyses, and engineering studies leading to conceptual definition and evaluation of a commercial hybrid power system that has the potential for supplying economically competitive electric power to a utility grid in the 1985-1990 time frame. The scope also includes the preparation of a development plan for the resolution of technical uncertainties and the preparation of plans and a proposal for Phase II of the program. The technical approach will be based on a central receiver solar energy collection scheme which supplies thermal energy to a combined cycle, generating system, consisting of a gas turbine cycle combined with a steam bottoming cycle by means of a heat recovery steam generator.

  20. Modeling Remote I/O versus Staging Tradeoff in Multi-Data Center Computing

    International Nuclear Information System (INIS)

    Suslu, Ibrahim H

    2014-01-01

    In multi-data center computing, data to be processed is not always local to the computation. This is a major challenge especially for data-intensive Cloud computing applications, since large amount of data would need to be either moved the local sites (staging) or accessed remotely over the network (remote I/O). Cloud application developers generally chose between staging and remote I/O intuitively without making any scientific comparison specific to their application data access patterns since there is no generic model available that they can use. In this paper, we propose a generic model for the Cloud application developers which would help them to choose the most appropriate data access mechanism for their specific application workloads. We define the parameters that potentially affect the end-to-end performance of the multi-data center Cloud applications which need to access large datasets over the network. To test and validate our models, we implemented a series of synthetic benchmark applications to simulate the most common data access patterns encountered in Cloud applications. We show that our model provides promising results in different settings with different parameters, such as network bandwidth, server and client capabilities, and data access ratio

  1. Limited role of I-123 IPT SPECT in differentiating essential tremor from early stage of Parkinson's disease

    International Nuclear Information System (INIS)

    Yoo, Y. H.; Yoon, M. J.; Lee, J. D.; Kim, J. H.; Lee, E.; Kim, H. S.; Choi, T. H.

    2002-01-01

    The study was to assess clinically applicable cut-off value in differential diagnosis among early stage of Parkinson's disease(PD) and essential tremor(ET) and normal control(NL) groups on I-123 IPT SPECT using dual head gamma camera both quantitatively and qualitatively. 50 NL (mean age 27.9), 20 early PD patients (mean age 58.2), 30 advanced PD patients (mean age 63.1) and 20 ET patients (mean age 39.9) were included and performed brain SPECT 2 hours after administration of I-123 IPT using dual head gamma camera. Recostructed SPECT data were assessed for specific/nonspecific binding ratio of striatum using (RBG-OCC/OCC, LBG-OCC/OCC) ratio. RBG-OCC/OCC and LBG-OCC/OCC ratio was decreased with increasing grade of H-Y stage in PD. Mean value of specific/nonspecific binding ratio was significantly different between advanced PD group and NL group. However, significant overlap of striatal specific/nonspecific bonding ratio were observed between early PD group and ET group. Suggested cut-off value of striatal binding ratio which can diagnose PD would be 2.1. Although I-123 IPT SPECT may be a useful method for the diagnosis of advanced PD and objective evaluation of progress of clinical stages, care should be made in the differential diagnosis of subclinical and early stage of PD and other motor distubances mimicking PD such as ET in view of significant overlap in striatal I-123 IPT specific/nonspecific binding ratio

  2. Research program in reactor core diagnostics with neutron noise methods: Stage 3. Final report; Forskningsprogram angaaende haerddiagnostik med neutronbrusmetoder. Etapp 3. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Pazsit, I.; Garis, N.S.; Karlsson, J.; Racz, A. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Reactor Physics

    1997-09-01

    Stage 3 of the program has been executed 96-04-12. The long term goal is to develop noise methods for identification and localization of perturbations in reactor cores. The main parts of the program consist of modelling the noise source, calculation of the space- and frequency dependent transfer function, calculation of the neutron noise via a convolution of the transfer function of the system and the noise source, i.e. the perturbation, and finally finding an inversion or unfolding procedure to determine noise source parameters from the neutron noise. Most previous work is based on very simple (analytical) reactor models for the calculation of the transfer function as well as analytical unfolding methods. The purpose of this project is to calculate the transfer function in a more realistic model as well as elaborating powerful inversion methods that do not require analytical transfer functions. The work in stage 3 is described under the following headlines: Further investigation of simplified models for the calculation of the neutron noise; Further investigation of methods based on neural networks; Further investigation of methods for detecting the vibrations and impacting of detectors; Application of static codes for determination of the neutron noise using the adiabatic approximation. 12 refs, 18 figs.

  3. Engineered Alloy Structures by Friction Stir Reaction Processing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort examines the feasibility of an innovative surface modification technology incorporating friction stir reaction processing for producing...

  4. Geometric phases and quantum computation

    International Nuclear Information System (INIS)

    Vedral, V.

    2005-01-01

    Full text: In my lectures I will talk about the notion of the geometric phase and explain its relevance for both fundamental quantum mechanics as well as quantum computation. The phase will be at first introduced via the idea of Pancharatnam which involves interference of three or more light beams. This notion will then be generalized to the evolving quantum systems. I will discuss both pure and mixed states as well as unitary and non-unitary evolutions. I will also show how the concept of the vacuum induced geometric phase arises in quantum optics. A simple measurement scheme involving a Mach Zehnder interferometer will be presented and will be used to illustrate all the concepts in the lecture. Finally, I will expose a simple generalization of the geometric phase to evolving degenerate states. This will be seen to lead to the possibility of universal quantum computation using geometric effects only. Moreover, this contains a promise of intrinsically fault tolerant quantum information processing, whose prospects will be outlined at the end of the lecture. (author)

  5. Appendectomy in the surgical staging of ovarian carcinoma.

    Science.gov (United States)

    Beşe, T; Kösebay, D; Kaleli, S; Oz, A U; Demirkiran, F; Gezer, A

    1996-06-01

    Extensive debulking is accepted as the primary method of operative management for carcinoma of the ovary. However, there is no consensus regarding the role of appendectomy in primary surgical treatment. The aim of this study was to assess the role of appendectomy in the surgical staging and cytoreduction of ovarian carcinoma. The study was a retrospective review of 90 primary malignant ovarian carcinoma patients who had an appendectomy in addition to primary cytoreductive surgery. Out of 90 patients, 10 (11.1%) had metastasis to the appendix. The rate of metastasis to the appendix was 11.5% (9/78) in malignant epithelial ovarian carcinomas and 8.3% (1/12) in non-epithelial ovarian tumors. Of the patients with metastasis in the appendix, malignant epithelial ovarian tumors were identified in 90% (serous: 70%; clear cell: 20%), and non-epithelial malignant ovarian tumor were disclosed in 10% (granulosa cell carcinoma). There were no metastases to the appendix in the other histological types. Although metastasis to the appendix was not observed in early stage ovarian carcinomas, it was detected in 21.4% (9/42) of stage III and 50% (1/2) of stage IV. Macroscopic tumor metastasis in the abdomen was noted in all patients with metastasis to the appendix. Appendectomy for stage I and II patients was not beneficial and did not affect final staging. As a result, for the proper staging of ovarian carcinoma there is no advantage to the addition of routine appendectomy to primary cytoreductive surgery in early stage (stage I and II) malignant epithelial ovarian tumors. Appendectomy would contribute to the cytoreduction of advanced stage disease if it is macroscopically involved.

  6. Bianchi type I cyclic cosmology from Lie-algebraically deformed phase space

    International Nuclear Information System (INIS)

    Vakili, Babak; Khosravi, Nima

    2010-01-01

    We study the effects of noncommutativity, in the form of a Lie-algebraically deformed Poisson commutation relations, on the evolution of a Bianchi type I cosmological model with a positive cosmological constant. The phase space variables turn out to correspond to the scale factors of this model in x, y, and z directions. According to the conditions that the structure constants (deformation parameters) should satisfy, we argue that there are two types of noncommutative phase space with Lie-algebraic structure. The exact classical solutions in commutative and type I noncommutative cases are presented. In the framework of this type of deformed phase space, we investigate the possibility of building a Bianchi I model with cyclic scale factors in which the size of the Universe in each direction experiences an endless sequence of contractions and reexpansions. We also obtain some approximate solutions for the type II noncommutative structure by numerical methods and show that the cyclic behavior is repeated as well. These results are compared with the standard commutative case, and similarities and differences of these solutions are discussed.

  7. Experimental investigation of the Ag–Bi–I ternary system and thermodynamic properties of the ternary phases

    International Nuclear Information System (INIS)

    Mashadieva, Leyla F.; Aliev, Ziya S.; Shevelkov, Andrei V.; Babanly, Mahammad B.

    2013-01-01

    Highlights: ► The self-consistent phase diagram of the Ag–Bi–I system is constructed. ► Ag 2 BiI 5 and AgBi 2 I 7 are the only ternary phases of the system. ► Standard thermodynamic functions of formation and the standard entropies of Ag 2 BiI 5 and AgBi 2 I 7 are calculated. - Abstract: The phase equilibriums in the Ag–Bi–I ternary system and thermodynamic properties of the ternary phases were experimentally determined by using DTA and XRD techniques and EMF measurements with the Ag 4 RbI 5 solid electrolyte. According to the obtained experimental results, the polythermal sections of the ternary phase diagram, its isothermal section at 300 K as well as the projection of the liquids surface have been revised. The fields of the primary crystallization and types and coordinates of nonvariant and monovariant equilibriums were determined. The partial molar functions of silver iodide and silver in the alloys as well as the standard thermodynamic functions of formation and the standard entropies of Ag 2 BiI 5 and AgBi 2 I 7 were calculated based on EMF measurements.

  8. The percentage of iNKT cells among other immune cells at various clinical stages of laryngeal cancer

    Directory of Open Access Journals (Sweden)

    Janusz Klatka

    2016-04-01

    Full Text Available Introduction: Invariant natural killer T (iNKT cells constitute a small population of immune cells that share functional and phenotypic characteristics of T lymphocytes and NK cells. Due to their involvement in specific and non-specific immune responses, iNKT cells may represent an important component of antitumor and anti-infectious immunity. Material and methods: Using flow cytometry, we analyzed the percentages of iNKT cells as well as T and B lymphocytes in peripheral blood of 50 laryngeal cancer patients at various clinical stages in comparison to healthy controls (n=15. Moreover, we determined the expression of CD25, CD69 and CD95 antigens on T lymphocytes.Results: The percentage of CD4+/CD3+ T lymphocytes in the controls was higher than in laryngeal cancer patients, both with early and late stages of the disease. The percentage of CD8+/CD3+ T lymphocytes in healthy controls was lower than in patients with early and late clinical stages of laryngeal cancer. Patients with advanced laryngeal cancer showed a lower percentage of iNKT cells and higher frequencies of T regulatory cells (Tregs than the controls. Advanced clinical stages of laryngeal cancer are associated with impaired activation of lymphocytes.Conclusions: Our study confirmed that laryngeal cancer cells exert a strong suppressor effect on the immune system of the host. This is reflected by a decrease in the percentage of iNKT cells that are capable of cancer cell elimination, and a concomitant increase in the percentage of Tregs. However, further studies are needed in order to explain the underlying mechanisms of immunosuppression and understand interactions between immune and cancer cells.

  9. Neuropsychiatric symptoms and quality of life in patients in the final phase of dementia.

    NARCIS (Netherlands)

    Koopmans, R.T.C.M.; Molen, M. van der; Raats, M.; Ettema, T.P.

    2009-01-01

    OBJECTIVES: To assess neuropsychiatric symptoms and quality of life in a group of patients in the final phase of dementia. METHODS: All patients with dementia (n = 216) residing on dementia special care units of two Dutch nursing homes were included in the study provided they met the criteria for

  10. Multifunctional Metal/Polymer Composite Fiber for Space Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Small Business Innovation Research Phase I Program, Syscom Technology, Inc. (STI) will fabricate a metallized multifunctional composite fiber from a...

  11. Staging structures of the intercalation compounds Ag/sub x/TiS2

    International Nuclear Information System (INIS)

    Bardhan, K.K.; Kirczenow, G.; Jackle, G.; Irwin, J.C.

    1986-01-01

    An extensive investigation of the structure, and in particular the staging, of powdered samples of the intercalation compounds Ag/sub x/TiS 2 (0 0 C. The (T,x) phase diagram contains three phases: a high-x (dense) stage-1 phase, a stage-disordered phase, which at low x or high temperatures appears to become a pure low-x (dilute) stage-1 phase, and a simple stage-2 phase. On the high-x side of its stability region the stage-2 phase undergoes an apparent first-order transition to the dense stage-1 phase, but on the high-temperature side it proceeds continuously, through stage-disordered states, to a dilute stage-1 phase. On the low-x side of the stage-2 region there is also a dilute stage-1 phase. At sufficiently high temperatures a novel coexistence of the two stage-1 phases is observed. This is the first time that the high-temperature stability limit of the stage-2 region has been probed in any intercalation compound. The results are compared with recent theoretical models

  12. Fiber Optic Microcantilever Sensor Coupled with Reactive Polymers for Vapor Phase Detection of Ammonia, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Luna Innovations proposes to adapt its current aqueous-based, fiber-optic microcantilever sensor technology for real-time, monitoring of ammonia in air. Phase I...

  13. Phase-separated CsI-NaCl scintillator grown by the Czochralski method

    Science.gov (United States)

    Yasui, Nobuhiro; Kobayashi, Tamaki; Ohashi, Yoshihiro; Den, Toru

    2014-08-01

    A phase-separated CsI-NaCl scintillator with light-guiding properties was grown by the Czochralski method. The CsI-NaCl eutectic phase usually consists of NaCl cylinders in a CsI matrix and contains grain boundaries. However, we have grown composites without grain boundaries by creating a convex solid/liquid interface, selecting a single grain by Dash's neck method, and increasing the diameter of the composite moderately. The good continuous convection flow required for these conditions was achieved by suppressing the drop in the aspect ratio of the melt height to the crucible radius with a double crucible setup. We successfully obtained a CsI-NaCl:Tl composite that was uniform with no grain boundaries greater than 30 mm in diameter.

  14. Optimization of the superconducting phase of hydrogen sulfide

    Science.gov (United States)

    Degtyarenko, N. N.; Masur, E. A.

    2015-12-01

    The electron and phonon spectra, as well as the densities of electron and phonon states of the SH3 phase and the stable orthorhombic structure of hydrogen sulfide SH2, are calculated for the pressure interval 100-225 GPa. It is found that the I4/ mmm phase can be responsible for the superconducting properties of metallic hydrogen sulfide along with the SH3 phase. Sequential stages for obtaining and conservation of the SH2 phase are proposed. The properties of two (SH2 and SH3) superconducting phases of hydrogen sulfide are compared.

  15. A Novel Cyclic Catalytic Reformer for Hydrocarbon Fuels, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed Small Business Innovative Research (SBIR) Phase I addresses development of a compact reformer system based on a cyclic partial oxidation (POx)...

  16. In situ Laser Diagnostics for Arc-Jet Facilities, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR Phase I effort, Los Gatos Research (LGR) proposes to develop novel instrumentation based on laser absorption spectroscopy techniques for ultrasensitive...

  17. Early positron emission tomography response-adapted treatment in stage I and II hodgkin lymphoma

    DEFF Research Database (Denmark)

    André, Marc P.E.; Girinsky, Théodore; Federico, Massimo

    2017-01-01

    Purpose Patients who receive combined modality treatment for stage I and II Hodgkin lymphoma (HL) have an excellent outcome. Early response evaluation with positron emission tomography (PET) scan may improve selection of patients who need reduced or more intensive treatments. Methods We performed...

  18. Properties predictive modeling through the concept of a hybrid interphase existing between phases in contact

    Science.gov (United States)

    Portan, D. V.; Papanicolaou, G. C.

    2018-02-01

    From practical point of view, predictive modeling based on the physics of composite material behavior is wealth generating; by guiding material system selection and process choices, by cutting down on experimentation and associated costs; and by speeding up the time frame from the research stage to the market place. The presence of areas with different properties and the existence of an interphase between them have a pronounced influence on the behavior of a composite system. The Viscoelastic Hybrid Interphase Model (VHIM), considers the existence of a non-homogeneous viscoelastic and anisotropic interphase having properties depended on the degree of adhesion between the two phases in contact. The model applies for any physical/mechanical property (e.g. mechanical, thermal, electrical and/or biomechanical). Knowing the interphasial variation of a specific property one can predict the corresponding macroscopic behavior of the composite. Moreover, the model acts as an algorithm and a two-way approach can be used: (i) phases in contact may be chosen to get the desired properties of the final composite system or (ii) the initial phases in contact determine the final behavior of the composite system, that can be approximately predicted. The VHIM has been proven, amongst others, to be extremely useful in biomaterial designing for improved contact with human tissues.

  19. Outcomes of Patients With Revised Stage I Clear Cell Sarcoma of Kidney Treated in National Wilms Tumor Studies 1-5

    International Nuclear Information System (INIS)

    Kalapurakal, John A.; Perlman, Elizabeth J.; Seibel, Nita L.; Ritchey, Michael; Dome, Jeffrey S.; Grundy, Paul E.

    2013-01-01

    Purpose: To report the clinical outcomes of children with revised stage I clear cell sarcoma of the kidney (CCSK) using the National Wilms Tumor Study Group (NWTS)-5 staging criteria after multimodality treatment on NWTS 1-5 protocols. Methods and Materials: All CCSK patients enrolled in the National Wilms Tumor Study Group protocols had their pathology slides reviewed, and only those determined to have revised stage I tumors according to the NWTS-5 staging criteria were included in the present analysis. All patients were treated with multimodality therapy according to the NWTS 1-5 protocols. Results: A total of 53 children were identified as having stage I CCSK. All patients underwent primary surgery with radical nephrectomy. The chemotherapy regimens used were as follows: regimen A, C, F, or EE in 4 children (8%); regimen DD or DD4A in 33 children (62%); regimen J in 4 children (8%); and regimen I in 12 children (22%). Forty-six patients (87%) received flank radiation therapy (RT). Seven children (13%) did not receive flank RT. The median delay between surgery and the initiation of RT was 9 days (range, 3-61). The median RT dose was 10.8 Gy (range, 10-36). The flank RT doses were as follows: 10.5 or 10.8 Gy in 25 patients (47%), 11-19.9 Gy in 2 patients (4%), 20-29.9 Gy in 9 patients (17%), and 30-40 Gy in 10 patients (19%). The median follow-up for the entire group was 17 years (range, 2-36). The relapse-free and cancer-specific survival rate was 100% at the last follow-up examination. Conclusions: The present results have demonstrated that children with revised stage I CCSK using the NWTS-5 staging criteria have excellent survival rates despite the use of varying RT doses and chemotherapy regimens in the NWTS 1-5 protocols.

  20. Innovative grinding wheel design for cost-effective machining of advanced ceramics. Phase I, final report

    Energy Technology Data Exchange (ETDEWEB)

    Licht, R.H.; Ramanath, S.; Simpson, M.; Lilley, E.

    1996-02-01

    Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics. This program was a cooperative effort involving three Norton groups representing a superabrasive grinding wheel manufacturer, a diamond film manufacturing division and a ceramic research center. The program was divided into two technical tasks, Task 1, Analysis of Required Grinding Wheel Characteristics, and Task 2, Design and Prototype Development. In Task 1 we performed a parallel path approach with Superabrasive metal-bond development and the higher technical risk, CVD diamond wheel development. For the Superabrasive approach, Task 1 included bond wear and strength tests to engineer bond-wear characteristics. This task culminated in a small-wheel screening test plunge grinding sialon disks. In Task 2, an improved Superabrasive metal-bond specification for low-cost machining of ceramics in external cylindrical grinding mode was identified. The experimental wheel successfully ground three types of advanced ceramics without the need for wheel dressing. The spindle power consumed by this wheel during test grinding of NC-520 sialon is as much as to 30% lower compared to a standard resin bonded wheel with 100 diamond concentration. The wheel wear with this improved metal bond was an order of magnitude lower than the resin-bonded wheel, which would significantly reduce ceramic grinding costs through fewer wheel changes for retruing and replacements. Evaluation of ceramic specimens from both Tasks 1 and 2 tests for all three ceramic materials did not show evidence of unusual grinding damage. The novel CVD-diamond-wheel approach was incorporated in this program as part of Task 1. The important factors affecting the grinding performance of diamond wheels made by CVD coating preforms were determined.

  1. All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer.

    Science.gov (United States)

    Melamed, Alexander; Rizzo, Anthony E; Nitecki, Roni; Gockley, Allison A; Bregar, Amy J; Schorge, John O; Del Carmen, Marcela G; Rauh-Hain, J Alejandro

    2017-07-01

    To compare all-cause mortality between women who underwent fertility-sparing surgery with those who underwent conventional surgery for stage I ovarian cancer. In a cohort study using the National Cancer Database, we identified women younger than 40 years diagnosed with stage IA and unilateral IC epithelial ovarian cancer between 2004 and 2012. Fertility-sparing surgery was defined as conservation of one ovary and the uterus. The primary outcome was time from diagnosis to death. We used propensity score methods to assemble a cohort of women who underwent fertility-sparing or conventional surgery but were otherwise similar on observed covariates and conducted survival analyses using the Kaplan-Meier method and Cox proportional hazard models. We identified 1,726 women with stage IA and unilateral IC epithelial ovarian cancer of whom 825 (47.8%) underwent fertility-sparing surgery. Fertility-sparing surgery was associated with younger age, residence in the northeastern and western United States, and serous or mucinous histology (Pfertility-sparing surgery and 37 deaths among propensity-matched women who underwent conventional surgery after a median follow-up of 63 months. Fertility-sparing surgery was not associated with hazard of death (hazard ratio 0.80, 95% confidence interval [CI] 0.49-1.29, P=.36). The probability of survival 10 years after diagnosis was 88.5% (95% CI 82.4-92.6) in the fertility-sparing group and 88.9% (95% CI 84.9-92.0) in the conventional surgery group. In patients with high-risk features such as clear cell histology, grade 3, or stage IC, 10-year survival was 80.5% (95% CI 68.5-88.3) among women who underwent fertility-sparing surgery and 83.4% (95% 76.0-88.7) among those who had conventional surgery (hazard ratio 0.86, 95% CI 0.49-1.53, P=.61). Compared with conventional surgery, fertility-sparing surgery was not associated with increased risk of death in young women with stage I epithelial ovarian cancer.

  2. Social Development Training Project. Stage I and Stage II. [The Granville Project].

    Science.gov (United States)

    Riches, Vivienne C., Ed.

    The book presents a training program developed at the Granville Work Preparation Centre in Australia, to teach mildly retarded adolescents basic social skills and competencies. The program is divided into two stages, with a total of 17 different skill areas. Stage 1 covers self-awareness, social/interpersonal skills, relaxation and behavioral self…

  3. Wireless, Passive Encoded Saw Sensors and Communication Links, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — There are several objectives of this Phase I proposal. One major objective is to investigate SAW sensor embodiments for pressure and acceleration. Two approaches...

  4. iROLL: does 3-D radioguided occult lesion localization improve surgical management in early-stage breast cancer?

    Science.gov (United States)

    Bluemel, Christina; Cramer, Andreas; Grossmann, Christoph; Kajdi, Georg W; Malzahn, Uwe; Lamp, Nora; Langen, Heinz-Jakob; Schmid, Jan; Buck, Andreas K; Grimminger, Hanns-Jörg; Herrmann, Ken

    2015-10-01

    To prospectively evaluate the feasibility of 3-D radioguided occult lesion localization (iROLL) and to compare iROLL with wire-guided localization (WGL) in patients with early-stage breast cancer undergoing breast-conserving surgery and sentinel lymph node biopsy (SLNB). WGL (standard procedure) and iROLL in combination with SLNB were performed in 31 women (mean age 65.1 ± 11.2 years) with early-stage breast cancer and clinically negative axillae. Patient comfort in respect of both methods was assessed using a ten point scale. SLNB and iROLL were guided by freehand SPECT (fhSPECT). The results of the novel 3-D image-based method were compared with those of WGL, ultrasound-based lesion localization, and histopathology. iROLL successfully detected the malignant primary and at least one sentinel lymph node in 97% of patients. In a single patient (3%), only iROLL, and not WGL, enabled lesion localization. The variability between fhSPECT and ultrasound-based depth localization of breast lesions was low (1.2 ± 1.4 mm). Clear margins were achieved in 81% of the patients; however, precise prediction of clear histopathological surgical margins was not feasible using iROLL. Patients rated iROLL as less painful than WGL with a pain score 0.8 ± 1.2 points (p localizing early-stage breast cancer in the course of breast-conserving surgery, and is a suitable replacement for WGL. As a single image-based procedure for localization of breast lesions and sentinel nodes, iROLL may improve the entire surgical procedure. However, no advantages of the image-guided procedure were found with regard to prediction of complete tumour resection.

  5. Effective treatment of Stage I uterine papillary serous carcinoma with high dose-rate vaginal apex radiation (192Ir) and chemotherapy

    International Nuclear Information System (INIS)

    Turner, Bruce C.; Knisely, Jonathan P. S.; Kacinski, Barry M.; Haffty, Bruce G.; Gumbs, Andrew A.; Roberts, Kenneth B.; Frank, Alex H.; Peschel, Richard E.; Rutherford, Thomas J.; Edraki, Babak; Kohorn, Ernest I.; Chambers, Setsuko K.; Schwartz, Peter E.; Wilson, Lynn D.

    1998-01-01

    Purpose: Uterine papillary serous carcinoma (UPSC) is a morphologically distinct variant of endometrial carcinoma that is associated with a poor prognosis, high recurrence rate, frequent clinical understaging, and poor response to salvage treatment. We retrospectively analyzed local control, actuarial overall survival (OS), actuarial disease-free survival (DFS), salvage rate, and complications for patients with Federation International of Gynecology and Obstetrics (FIGO) (1988) Stage I UPSC. Methods and Materials: This retrospective analysis describes 38 patients with FIGO Stage I UPSC who were treated with the combinations of radiation therapy, chemotherapy, total abdominal hysterectomy, and bilateral salpingo-oophorectomy (TAH/BSO), with or without a surgical staging procedure. Twenty of 38 patients were treated with a combination of low dose-rate (LDR) uterine/vaginal brachytherapy using 226 Ra or 137 Cs and conventional whole-abdomen radiation therapy (WART) or whole-pelvic radiation therapy (WPRT). Of 20 patients (10%) in this treatment group, 2 received cisplatin chemotherapy. Eighteen patients were treated with high dose-rate (HDR) vaginal apex brachytherapy using 192 Ir with an afterloading device and cisplatin, doxorubicin, and cyclophosphamide (CAP) chemotherapy (5 of 18 patients). Only 6 of 20 UPSC patients treated with combination LDR uterine/vaginal brachytherapy and conventional external beam radiotherapy underwent complete surgical staging, consisting of TAH/BSO, pelvic/para-aortic lymph node sampling, omentectomy, and peritoneal fluid analysis, compared to 15 of 18 patients treated with HDR vaginal apex brachytherapy. Results: The 5-year actuarial OS for patients with complete surgical staging and adjuvant radiation/chemotherapy treatment was 100% vs. 61% for patients without complete staging (p = 0.002). The 5-year actuarial OS for all Stage I UPSC patients treated with postoperative HDR vaginal apex brachytherapy and systemic chemotherapy was 94

  6. Pipe Overpack Container Fire Testing: Phase I & II

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, Victor G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ammerman, Douglas J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lopez, Carlos [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gill, Walter [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    The Pipe Overpack Container (POC) was developed at Rocky Flats to transport plutonium residues with higher levels of plutonium than standard transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP) for disposal. In 1996 Sandia National Laboratories (SNL) conducted a series of tests to determine the degree of protection POCs provided during storage accident events. One of these tests exposed four of the POCs to a 30-minute engulfing pool fire, resulting in one of the 7A drum overpacks generating sufficient internal pressure to pop off its lid and expose the top of the pipe container (PC) to the fire environment. The initial contents of the POCs were inert materials, which would not generate large internal pressure within the PC if heated. However, POCs are now being used to store combustible TRU waste at Department of Energy (DOE) sites. At the request of DOE’s Office of Environmental Management (EM) and National Nuclear Security Administration (NNSA), starting in 2015 SNL conducted a new series of fire tests to examine whether PCs with combustibles would reach a temperature that would result in (1) decomposition of inner contents and (2) subsequent generation of sufficient gas to cause the PC to over-pressurize and release its inner content. Tests conducted during 2015 and 2016, and described herein, were done in two phases. The goal of the first phase was to see if the PC would reach high enough temperatures to decompose typical combustible materials inside the PC. The goal of the second test phase was to determine under what heating loads (i.e., incident heat fluxes) the 7A drum lid pops off from the POC drum. This report will describe the various tests conducted in phase I and II, present preliminary results from these tests, and discuss implications for the POCs.

  7. Lightweight, High Strength Nano-Composite Magnesium for Radiators, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase I SBIR, Terves will develop processing routes to produce high thermal conductivity magnesium composites for use in heat transfer applications such as...

  8. Lymphovascular space invasion and tumor differentiation are predictors for postoperative recurrence in patients with pathological stage I nonsmall cell lung cancer

    Directory of Open Access Journals (Sweden)

    Ying-Yi Chen

    2014-08-01

    Conclusion: Tumor differentiation and LVSI were predictors of postoperative relapse for patients with pathological stage I NSCLC. Risk factors of postoperative recurrence in patients with pathological Stage I NSCLC may enable us to optimize the patient selection for postoperative adjuvant therapies to prevent possibly occult micrometastases.

  9. Solid phase 125I labelled radioimmunoassay for spermidine

    International Nuclear Information System (INIS)

    Zhao Shimin

    1991-01-01

    Using 125 I labelled monoclonal antibody against spermidine and solid phase antigen spermidine-bovine serum albumin conjugate, the radioimmunoassay for spermidine was developed. The sensitivity of this method was about 8 times higher than that of liquid phase 14 C labelled spermidine radioimmunoassay, reaching detection limit of 10 ng/ml (0.5 ng/tube). The working range of standard curve was 0-10 5 ng/ml. The new method was suitable for spermidine measurements in saliva, stomach fluid, and cerebrospinal fluid. The coefficients of variation (CV) of within and between-assay were 4% and 13%, respectively. Preliminary clinical measurements showed that the spermidine levels in saliva of cancer patients and in cerebrospinal fluid of leukemia patients were significantly elevated

  10. Technical realization of the VISA-2 Project, contract: 2.01/ I phase, Volume No. I; Tehnicka realizacija projekta VISA-2, ugovor: 2.01/I faza, Album br. I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1963-12-15

    Cooperation between the Institutes in Vinca and Saclay has started by carrying out the task 'Technical realization of the VISA-2 project' which should enable: obtaining new experimental spaces in the RA reactor with high fast neutron flux for sample irradiation; obtaining experience in reactor continual operation for few months at nominal power of 6.5 MW and increase of RA reactor utilization; solving the problem of activated channels and samples transport, problems of working in hot cells; obtaining irradiated samples for examining radiation effects first in Saclay and later in Vinca. The project is divided in three phases. Phase one covers the reconstruction of the RA reactor fuel channels according to the VISA-2 project demands. The second phase includes the activities related to measuring devices for measuring the temperatures at the incoming and outgoing heavy water in 5 VISA-2 channels, as well as temperature of the samples (55 thermocouples) and testing the channels and capsules after their insertion in the reactor. The third phase includes activities are related to problems of transport of radioactive channels and VISA-2 capsules, problems of cutting as well as packing and transporting of irradiated samples from Vinca to Saclay. This volume includes all the relevant documents for completing the task including contracts, needed preliminary calculations as well as safety analysis. [Serbo-Croat] Saradnja izmedju Instituta u Vinci i Saclay-u zapoceta je realizacijom zadatka 'Tehnicka realizacije projekta VISA-2' koji treba da omoguci: dobijanje novih eksperimentalnih prostora u reaktoru RA sa visokom vrednoscu fluksa brzih neutrona za ozracivanje uzoraka; sticanje pogonskih iskustava u visemesecnom kontilualnom radu na nominalnoj snazi od 6,5 MW i povecanje stepena koriscenja reaktora RA; resenje pitanja transporta aktivnih kanala i uzoraka, problema rada u vrucim celijama; dobijanje ozracenih uzoraka za izucavanje, u prvo vreme u Saclay-u, a kasnije i u Vinci

  11. Research and development program in reactor diagnostics and monitoring with neutron noise methods. Stage 7. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pazsit, I.; Demaziere, C.; Arzhanov, V. [Chalmers Univ. of Technology, Goeteborg (Sweden). Department of Reactor Physics; Garis, N.S. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2001-08-01

    neutronic model could be used for routine calculations. Such a simplified model has plenty of applications, both theoretical and practical ones. Therefore, much emphasis was put in this stage on the calculational efficiency of the noise simulator. The CPU time was reduced by a factor 15 and the required memory by a factor 8, compared to the previous version. Benchmarking of this noise simulator showed that the level of accuracy on the flux noise (both its amplitude and its phase) is excellent for all noise source types. However, these comparisons were made for homogeneous systems since these are the only systems for which analytical solutions can be determined. It is expected that the accuracy could deteriorate for heterogeneous systems. Thus a need remains to use a more efficient spatial discretization scheme than the finite difference one. The 2-D 2-group noise simulator calculates the neutron noise induced by any type of noise source, spatially distributed or not (i.e. localised). It can also be used in an inversion task; the neutron noise can be used as input parameter to an algorithm which determines the location of the corresponding noise source. Such a localisation task was previously developed. In this stage, the localisation algorithm was improved since the 2-D 2-group neutron noise simulator was used for the calculation of the transfer function, as opposed to the transfer function corresponding to a homogeneous system. At that time, this means that any realistic core can be studied via this algorithm. The localisation algorithm was applied to the Forsmark 1 channel instability event monitored in January 1997 during fuel cycle 16. By selecting a proper set of detectors, the noise source was located close to a fuel element that was discovered to be unseated. Nevertheless, selecting different detector combinations give also sometimes different results, which suggests that there were several simultaneous noise sources in the Forsmark 1 case. Detection of impacting of

  12. Linfadenectomia Axilar Conservadora no Câncer de Mama Estádio Clínico I Conservative Axillary Dissection in Stage I Breast Cancer

    Directory of Open Access Journals (Sweden)

    Luiz Antonio Guimarães Brondi

    2000-01-01

    Full Text Available Objetivo: determinar a eficácia da linfadenectomia axilar conservadora (esvaziamento dos níveis I e II no tratamento cirúrgico do câncer da mama estádio I. Métodos: foram avaliados os resultados de 142 cirurgias realizadas em pacientes portadoras de câncer mamário estádio I (T1NO entre janeiro/93 e dezembro/98. Removidos os linfonodos axilares presentes nos níveis I e II com preservação dos músculos peitorais, os mesmos foram dissecados pelo próprio autor (LAGB, sendo posteriormente examinados histopatologicamente com a realização de apenas 1 corte por linfonodo. A quadrantectomia foi realizada em 138 casos e a mastectomia modificada segundo Patey em 4 casos. Houve predomínio dos casos T1c (130 casos. Resultados: foram removidos 3.282 linfonodos (2.456 presentes no nível I e 826 no nível II com um número médio de 23,1 linfonodos por axila. Desse total, apenas 68 estavam comprometidos (2,1%. Skip metastasis estava presente em apenas um caso (0,7%. Foram observados 35 casos de falso-negativos clínicos (24,6%, estando o nível I comprometido em 34 casos (97,1% e o nível II em apenas 2 casos (5,7%. A axila estava negativa nos 107 casos restantes (75,4%. Conclusão: a dissecção axilar dos níveis I e II é suficiente para tratar a axila no estádio I do câncer de mama. Se linfonodos suspeitos são identificados durante a cirurgia, os gânglios do nível III e o grupo interpeitoral de Rotter deverão ser retirados.Purpose: to evaluate the efficacy of conservative axillary dissection (levels I and II in the surgical treatment of stage I breast cancer. Methods: the results of 142 mastectomies performed from January/93 to December/98 in patients with clinical stage I breast cancer (T1NO were evaluated. Removing the axillary lymph nodes present at levels I and II, with the preservation of the pectoralis muscles, the axillary lymph nodes were dissected by the author (LAGB, and subsequently one section of each lymph node was

  13. Compact 2050 nm Semiconductor Diode Laser Master Oscillator, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I effort seeks to develop DFB laser master oscillators at the novel wavelength of 12050 nm. Two prototypes will be built, tested, and delivered ....

  14. Phase I and II feasibility study report for the 300-FF-5 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The purpose of this Phase I/II feasibility study is to assemble and screen a list of alternatives for remediation of the 300-FF-5 operable site on the Hanford Reservation. This screening is based on information gathered in the Phase I Remedial Investigation (RI) and on currently available information on remediation technologies. The alternatives remaining after screening provide a range of response actions for remediation. In addition, key data needs are identified for collection during a Phase II RI (if necessary). This Phase I/II FS represents a primary document as defined by the Tri-Party Agreement, but will be followed by a Phase III FS that will further develop the alternatives and provide a detailed evaluation of them. The following remedial action objectives were identified for the 300-FF-5 operable unit: Limit current human exposure to contaminated groundwater in the unit; Limit discharge of contaminated groundwater to the Columbia River; Reduce contaminant concentrations in groundwater below acceptable levels by the year 2018.

  15. Phase I and II feasibility study report for the 300-FF-5 operable unit

    International Nuclear Information System (INIS)

    1993-01-01

    The purpose of this Phase I/II feasibility study is to assemble and screen a list of alternatives for remediation of the 300-FF-5 operable site on the Hanford Reservation. This screening is based on information gathered in the Phase I Remedial Investigation (RI) and on currently available information on remediation technologies. The alternatives remaining after screening provide a range of response actions for remediation. In addition, key data needs are identified for collection during a Phase II RI (if necessary). This Phase I/II FS represents a primary document as defined by the Tri-Party Agreement, but will be followed by a Phase III FS that will further develop the alternatives and provide a detailed evaluation of them. The following remedial action objectives were identified for the 300-FF-5 operable unit: Limit current human exposure to contaminated groundwater in the unit; Limit discharge of contaminated groundwater to the Columbia River; Reduce contaminant concentrations in groundwater below acceptable levels by the year 2018

  16. Final Report on Two-Stage Fast Spectrum Fuel Cycle Options

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Won Sik [Purdue Univ., West Lafayette, IN (United States); Lin, C. S. [Purdue Univ., West Lafayette, IN (United States); Hader, J. S. [Purdue Univ., West Lafayette, IN (United States); Park, T. K. [Purdue Univ., West Lafayette, IN (United States); Deng, P. [Purdue Univ., West Lafayette, IN (United States); Yang, G. [Purdue Univ., West Lafayette, IN (United States); Jung, Y. S. [Purdue Univ., West Lafayette, IN (United States); Kim, T. K. [Argonne National Lab. (ANL), Argonne, IL (United States); Stauff, N. E. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-30

    This report presents the performance characteristics of two “two-stage” fast spectrum fuel cycle options proposed to enhance uranium resource utilization and to reduce nuclear waste generation. One is a two-stage fast spectrum fuel cycle option of continuous recycle of plutonium (Pu) in a fast reactor (FR) and subsequent burning of minor actinides (MAs) in an accelerator-driven system (ADS). The first stage is a sodium-cooled FR fuel cycle starting with low-enriched uranium (LEU) fuel; at the equilibrium cycle, the FR is operated using the recovered Pu and natural uranium without supporting LEU. Pu and uranium (U) are co-extracted from the discharged fuel and recycled in the first stage, and the recovered MAs are sent to the second stage. The second stage is a sodium-cooled ADS in which MAs are burned in an inert matrix fuel form. The discharged fuel of ADS is reprocessed, and all the recovered heavy metals (HMs) are recycled into the ADS. The other is a two-stage FR/ADS fuel cycle option with MA targets loaded in the FR. The recovered MAs are not directly sent to ADS, but partially incinerated in the FR in order to reduce the amount of MAs to be sent to the ADS. This is a heterogeneous recycling option of transuranic (TRU) elements

  17. Phase development and kinetics of high temperature Bi-2223 phase

    International Nuclear Information System (INIS)

    Yavuz, M.; Maeda, H.; Hua, K.L.; Shi, X.D.

    1998-01-01

    The two-dimensional nucleation (random)-growth mechanism were observed as a support for the related previous works, which is attributable to the growth of the Bi-2223 grain in the a-b plane direction of the Bi-2212 matrix is being much faster than in the c-direction, or that the early-formed plate-like 2212 phase confines the 2223 product. At the beginning of the reaction, the additional phases are partially melted. Because of the structure, composition and thermal fluctuation, the 2223 nucleates and grows in the phase boundary between the liquid phase and Bi-2212. It was shown here that the nucleation and the growth rate were relatively fast between 0 and 36 h. At the final stage, between 36 and 60 h, because of the impingement of the growth fronts of different nuclei, the high formation rate of 2223 is suppressed. The major reactant 2212 remains as a solid and its plate-like configuration determines the two dimensional nature of the reaction. The amount of liquid forms during reaction is small. (orig.)

  18. Discommensurates and incommensurate phases

    International Nuclear Information System (INIS)

    Gordon, Mirta Beatriz

    1983-01-01

    In its first part, this research thesis reports the study of the commensurate-incommensurate (C-I) transition of single layers of rare gases adsorbed on graphite. The anharmonicity of the interaction between adatoms could explain experimental results corresponding to krypton. The author also studied the orientation instability of the single layer with respect to the chemical potential. Near the C-I transition, walls or discommensurates are oriented in substrate symmetry directions which are determined. The effect of substrate deformation on C-I transition is also studied. In the second part, the author studied the phase diagram at low temperature of the anisotropic Ising model with competing interactions for the approximation of the mean field. Finally, the author presents a phenomenological model of Cerium Antimony which reproduces a large part of its phase diagram [fr

  19. Colorectal cancer stages transcriptome analysis.

    Directory of Open Access Journals (Sweden)

    Tianyao Huo

    Full Text Available Colorectal cancer (CRC is the third most common cancer and the second leading cause of cancer-related deaths in the United States. The purpose of this study was to evaluate the gene expression differences in different stages of CRC. Gene expression data on 433 CRC patient samples were obtained from The Cancer Genome Atlas (TCGA. Gene expression differences were evaluated across CRC stages using linear regression. Genes with p≤0.001 in expression differences were evaluated further in principal component analysis and genes with p≤0.0001 were evaluated further in gene set enrichment analysis. A total of 377 patients with gene expression data in 20,532 genes were included in the final analysis. The numbers of patients in stage I through IV were 59, 147, 116 and 55, respectively. NEK4 gene, which encodes for NIMA related kinase 4, was differentially expressed across the four stages of CRC. The stage I patients had the highest expression of NEK4 genes, while the stage IV patients had the lowest expressions (p = 9*10-6. Ten other genes (RNF34, HIST3H2BB, NUDT6, LRCh4, GLB1L, HIST2H4A, TMEM79, AMIGO2, C20orf135 and SPSB3 had p value of 0.0001 in the differential expression analysis. Principal component analysis indicated that the patients from the 4 clinical stages do not appear to have distinct gene expression pattern. Network-based and pathway-based gene set enrichment analyses showed that these 11 genes map to multiple pathways such as meiotic synapsis and packaging of telomere ends, etc. Ten of these 11 genes were linked to Gene Ontology terms such as nucleosome, DNA packaging complex and protein-DNA interactions. The protein complex-based gene set analysis showed that four genes were involved in H2AX complex II. This study identified a small number of genes that might be associated with clinical stages of CRC. Our analysis was not able to find a molecular basis for the current clinical staging for CRC based on the gene expression patterns.

  20. The Role of Vaginal Brachytherapy in the Treatment of Surgical Stage I Papillary Serous or Clear Cell Endometrial Cancer

    International Nuclear Information System (INIS)

    Barney, Brandon M.; Petersen, Ivy A.; Mariani, Andrea; Dowdy, Sean C.; Bakkum-Gamez, Jamie N.; Haddock, Michael G.

    2013-01-01

    Objectives: The optimal adjuvant therapy for International Federation of Gynecology and Obstetrics (FIGO) stage I papillary serous (UPSC) or clear cell (CC) endometrial cancer is unknown. We report on the largest single-institution experience using adjuvant high-dose-rate vaginal brachytherapy (VBT) for surgically staged women with FIGO stage I UPSC or CC endometrial cancer. Methods and Materials: From 1998-2011, 103 women with FIGO 2009 stage I UPSC (n=74), CC (n=21), or mixed UPSC/CC (n=8) endometrial cancer underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy followed by adjuvant high-dose-rate VBT. Nearly all patients (n=98, 95%) also underwent extended lymph node dissection of pelvic and paraortic lymph nodes. All VBT was performed with a vaginal cylinder, treating to a dose of 2100 cGy in 3 fractions. Thirty-five patients (34%) also received adjuvant chemotherapy. Results: At a median follow-up time of 36 months (range, 1-146 months), 2 patients had experienced vaginal recurrence, and the 5-year Kaplan Meier estimate of vaginal recurrence was 3%. The rates of isolated pelvic recurrence, locoregional recurrence (vaginal + pelvic), and extrapelvic recurrence (including intraabdominal) were similarly low, with 5-year Kaplan-Meier estimates of 4%, 7%, and 10%, respectively. The estimated 5-year overall survival was 84%. On univariate analysis, delivery of chemotherapy did not affect recurrence or survival. Conclusions: VBT is effective at preventing vaginal relapse in women with surgical stage I UPSC or CC endometrial cancer. In this cohort of patients who underwent comprehensive surgical staging, the risk of isolated pelvic or extrapelvic relapse was low, implying that more extensive adjuvant radiation therapy is likely unnecessary.