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Sample records for stage xiii blastula

  1. Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos.

    Directory of Open Access Journals (Sweden)

    Anthony J Robertson

    Full Text Available The Runt homology domain (Runx defines a metazoan family of sequence-specific transcriptional regulatory proteins that are critical for animal development and causally associated with a variety of mammalian cancers. The sea urchin Runx gene SpRunt-1 is expressed throughout the blastula stage embryo, and is required globally during embryogenesis for cell survival and differentiation.Depletion of SpRunt-1 by morpholino antisense-mediated knockdown causes a blastula stage deficit in cell proliferation, as shown by bromodeoxyuridine (BrdU incorporation and direct cell counts. Reverse transcription coupled polymerase chain reaction (RT-PCR studies show that the cell proliferation deficit is presaged by a deficit in the expression of several zygotic wnt genes, including wnt8, a key regulator of endomesoderm development. In addition, SpRunt-1-depleted blastulae underexpress cyclinD, an effector of mitogenic Wnt signaling. Blastula stage cell proliferation is also impeded by knockdown of either wnt8 or cyclinD. Chromatin immunoprecipitation (ChIP indicates that Runx target sites within 5' sequences flanking cyclinD, wnt6 and wnt8 are directly bound by SpRunt-1 protein at late blastula stage. Furthermore, experiments using a green fluorescent protein (GFP reporter transgene show that the blastula-stage operation of a cis-regulatory module previously shown to be required for wnt8 expression (Minokawa et al., Dev. Biol. 288: 545-558, 2005 is dependent on its direct sequence-specific interaction with SpRunt-1. Finally, inhibitor studies and immunoblot analysis show that SpRunt-1 protein levels are negatively regulated by glycogen synthase kinase (GSK-3.These results suggest that Runx expression and Wnt signaling are mutually linked in a feedback circuit that controls cell proliferation during development.

  2. Extracellular matrix synthesis in blastula and gastrula stages of normal and hybrid frog embryos

    International Nuclear Information System (INIS)

    Johnson, K.E.

    1978-01-01

    Pulse-chase labelling experiments and light- and electron-microscopic autoradiography were used to examine the site of synthesis, mode of transport, and sites of deposition of fucose-, glucose- and mannose-labelled materials in different developmental stages of normal developing Rana pipiens embryos and interspecific hybrid embryos formed by fertilizing the eggs of R. pipiens with the sperm of R. catesbeiana. In both normal and hybrid embryos, after a 15-30 min pulse, grains are closely associated with juxtanuclear and cytoplasmic collections of membrane-bound vescicles which resemble the Golgi apparatus. In normal embryos following a 15-30 min pulse and a 60-min chase, grains are largely cleared from the cytoplasmic vescicles and deposited in the extra-cellular spaces or along cell surfaces. In contrast, arrested hybrid embryos given a 15-30 min pulse and a 60-min chase show a marked accumulation of grains over cytoplasmic structures such as the Golgi apparatus and vescicular elements in the cell cortex. Certain interesting features of regional variation in synthetic activity in developing normal embryos are also described. (author)

  3. Sea urchin blastula: extent of cellular determination

    Energy Technology Data Exchange (ETDEWEB)

    Timourian, H.; Watchmaker, G.

    The extent of cellular determination at the blastula stage of sea urchins has been investigated by using as parameters the morphological differentiation and cellular interactions of dissociated blastula cells under conditions that either promote or discourage their reaggregation and reconstitution into embryos. The dissociated blastula cells have the capacity to differentiate into at least three different specific cell types that occur in the normally developing sea urchin embryo. Of these, ciliated epithelium is known to originate in the animal half, and spindle-shaped cells and polyfilamentous cells are of mesenchymal origin and are derived from the vegetal half. The formation of ciliated epithelium and blastulation requires calcium and hyalin; the cellular differentiation and interactions of the mesenchymal cells do not. The basic difference in calcium requirement is explored in terms of differential hyalin synthesis or secretion by the cells at either equatorial half of the embryo. The animalizing effect of zinc and the vegetalizing effect of lithium can be explained in part by their enhancement and reduction, respectively, of hyalin gelation by calcium. Literature relating to other basic differences along the animal-vegetal axis of the embryo is appraised. These differences include the use and the assembly of microtubule protein and quantitative RNA synthesis during both the cleavage and blastula stages. (auth)

  4. Morphological diversity of blastula formation and gastrulation in temnopleurid sea urchins.

    Science.gov (United States)

    Kitazawa, Chisato; Fujii, Tsubasa; Egusa, Yuji; Komatsu, Miéko; Yamanaka, Akira

    2016-11-15

    Embryos of temnopleurid sea urchins exhibit species-specific morphologies. While Temnopleurus toreumaticus has a wrinkled blastula and then invaginates continuously at gastrulation, others have a smooth blastula and their invagination is stepwise. We studied blastula and gastrula formation in four temnopleurids using light and scanning electron microscopy to clarify the mechanisms producing these differences. Unlike T. toreumaticus, blastomeres of mid-blastulae in T. reevesii, T. hardwickii and Mespilia globulus formed pseudopods. Before primary mesenchyme cells ingressed, embryos developed an area of orbicular cells in the vegetal plate. The cells surrounding the orbicular cells extended pseudopods toward the orbicular cell area in three Temnopleurus species. In T. toreumaticus, the extracellular matrix was well-developed and developed a hole-like structure that was not formed in others. Gastrulation of T. reevesii, T. hardwickii and M. globulus was stepwise, suggesting that differences of gastrulation are caused by all or some of the following factors: change of cell shape, rearrangement, pushing up and towing of cells. We conclude that (1) many aspects of early morphogenesis differ even among very closely related sea urchins with indirect development and (2) many of these differences may be caused by the cell shape and structure of blastomeres or by differences in extracellular matrix composition. © 2016. Published by The Company of Biologists Ltd.

  5. Morphological diversity of blastula formation and gastrulation in temnopleurid sea urchins

    Directory of Open Access Journals (Sweden)

    Chisato Kitazawa

    2016-11-01

    Full Text Available Embryos of temnopleurid sea urchins exhibit species-specific morphologies. While Temnopleurus toreumaticus has a wrinkled blastula and then invaginates continuously at gastrulation, others have a smooth blastula and their invagination is stepwise. We studied blastula and gastrula formation in four temnopleurids using light and scanning electron microscopy to clarify the mechanisms producing these differences. Unlike T. toreumaticus, blastomeres of mid-blastulae in T. reevesii, T. hardwickii and Mespilia globulus formed pseudopods. Before primary mesenchyme cells ingressed, embryos developed an area of orbicular cells in the vegetal plate. The cells surrounding the orbicular cells extended pseudopods toward the orbicular cell area in three Temnopleurus species. In T. toreumaticus, the extracellular matrix was well-developed and developed a hole-like structure that was not formed in others. Gastrulation of T. reevesii, T. hardwickii and M. globulus was stepwise, suggesting that differences of gastrulation are caused by all or some of the following factors: change of cell shape, rearrangement, pushing up and towing of cells. We conclude that (1 many aspects of early morphogenesis differ even among very closely related sea urchins with indirect development and (2 many of these differences may be caused by the cell shape and structure of blastomeres or by differences in extracellular matrix composition.

  6. Scanning electron microscopy study of adhesion in sea urchin blastulae. M.S. Thesis

    Science.gov (United States)

    Crowther, Susan D.

    1988-01-01

    The dissociation supernatant (DS) isolated by disaggregating Strongylocentrotus purpuratus blastulae in calcium- and magnesium-free seawater specifically promotes reaggregation of S. purpuratus blastula cells. The purpose of this study was to use scanning electron microscopy to examine the gross morphology of aggregates formed in the presence of DS to see if it resembles adhesion in partially dissociated blastulae. A new reaggregation procedure developed here, using large volumes of cell suspension and a large diameter of rotation, was utilized to obtain sufficient quantities of aggregates for scanning electron microscopy. The results indicate that aggregates formed in the presence of DS resemble partially dissociated intact embryos in terms of the direct cell-cell adhesion observed. DS did not cause aggregation to form as a result of the entrapment of cells in masses of extracellular material. These studies provide the groundwork for further studies using transmission electron microscopy to more precisely define the adhesive contacts made by cells in the presence of the putative adhesion molecules present in DS.

  7. XIII International Workshop on Hadron Physics

    CERN Document Server

    2015-01-01

    The XIII International Workshop on Hadron Physics, XIII Hadron Physics, is intended for graduate students, postdocs and researchers in Hadronic Physics, High Energy Physics, Astrophysics and Effective Field Theories, who wish to improve their theoretical background, learn about recent experimental results and develop collaboration projects. The series Hadron Physics, in activity since 1988, has the format of an advanced school and has the objective to introduce, in a series of pedagogical lectures, new lines of research in Strong Interaction Physics, mainly concerned with QCD. It envisages also to stimulate collaborations in international level.

  8. Ca2+ signaling and early embryonic patterning during the blastula and gastrula periods of zebrafish and Xenopus development.

    Science.gov (United States)

    Webb, Sarah E; Miller, Andrew L

    2006-11-01

    It has been proposed that Ca(2+) signaling, in the form of pulses, waves and steady gradients, may play a crucial role in key pattern forming events during early vertebrate development [L.F. Jaffe, Organization of early development by calcium patterns, BioEssays 21 (1999) 657-667; M.J. Berridge, P. Lipp, M.D. Bootman, The versatility and universality of calcium signaling, Nat. Rev. Mol. Cell Biol. 1 (2000) 11-21; S.E. Webb, A.L. Miller, Calcium signalling during embryonic development, Nat. Rev. Mol. Cell Biol. 4 (2003) 539-551]. With reference to the embryos of zebrafish (Danio rerio) and the frog, Xenopus laevis, we review the Ca(2+) signals reported during the Blastula and Gastrula Periods. This developmental window encompasses the major pattern forming events of epiboly, involution, and convergent extension, which result in the establishment of the basic germ layers and body axes [C.B. Kimmel, W.W. Ballard, S.R. Kimmel, B. Ullmann, T.F. Schilling, Stages of embryonic development of the zebrafish, Dev. Dyn. 203 (1995) 253-310]. Data will be presented to support the suggestion that propagating waves (both long and short range) of Ca(2+) release, followed by sequestration, may play a crucial role in: (1) Coordinating cell movements during these pattern forming events and (2) Contributing to the establishment of the basic embryonic axes, as well as (3) Helping to define the morphological boundaries of specific tissue domains and embryonic structures, including future organ anlagen [E. Gilland, A.L. Miller, E. Karplus, R. Baker, S.E. Webb, Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation, Proc. Natl. Acad. Sci. USA 96 (1999) 157-161; J.B. Wallingford, A.J. Ewald, R.M. Harland, S.E. Fraser, Calcium signaling during convergent extension in Xenopus, Curr. Biol. 11 (2001) 652-661]. The various potential targets of these Ca(2+) transients will also be discussed, as well as how they might integrate with other known pattern forming

  9. Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.

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    Sarah L Kerns

    Full Text Available In many organisms early development is under control of the maternal genome and zygotic gene expression is delayed until the mid-blastula transition (MBT. As zygotic transcription initiates, cell cycle checkpoints become activated and the tempo of cell division slows. The mechanisms that activate zygotic transcription at the MBT are incompletely understood, but they are of interest because they may resemble mechanisms that cause stem cells to stop dividing and terminally differentiate. The unstable regulatory protein Geminin is thought to coordinate cell division with cell differentiation. Geminin is a bi-functional protein. It prevents a second round of DNA replication during S and G2 phase by binding and inhibiting the essential replication factor Cdt1. Geminin also binds and inhibits a number of transcription factors and chromatin remodeling proteins and is thought to keep dividing cells in an undifferentiated state. We previously found that the cells of Geminin-deficient Xenopus embryos arrest in G2 phase just after the MBT then disintegrate at the onset of gastrulation. Here we report that they also fail to express most zygotic genes. The gene expression defect is cell-autonomous and is reproduced by over-expressing Cdt1 or by incubating the embryos in hydroxyurea. Geminin deficient and hydroxyurea-treated blastomeres accumulate DNA damage in the form of double stranded breaks. Bypassing the Chk1 pathway overcomes the cell cycle arrest caused by Geminin depletion but does not restore zygotic gene expression. In fact, bypassing the Chk1 pathway by itself induces double stranded breaks and abolishes zygotic transcription. We did not find evidence that Geminin has a replication-independent effect on transcription. We conclude that Geminin is required to maintain genome integrity during the rapid cleavage divisions, and that DNA damage disrupts zygotic gene transcription at the MBT, probably through activation of DNA damage checkpoint pathways.

  10. Tissue regenerating functions of coagulation factor XIII

    DEFF Research Database (Denmark)

    Soendergaard, C; Kvist, P H; Seidelin, J B

    2013-01-01

    The protransglutaminase factor XIII (FXIII) has recently gained interest within the field of tissue regeneration, as it has been found that FXIII significantly influences wound healing by exerting a multitude of functions. It supports haemostasis by enhancing platelet adhesion to damaged endothel......The protransglutaminase factor XIII (FXIII) has recently gained interest within the field of tissue regeneration, as it has been found that FXIII significantly influences wound healing by exerting a multitude of functions. It supports haemostasis by enhancing platelet adhesion to damaged...... endothelium, and by its cross-linking activity it stabilizes the formed fibrin clot. Furthermore, FXIII limits bacterial dissemination from the wound and incorporates macromolecules of importance for cellular infiltration supporting cell migration and survival. FXIII-mediated complex formation of the VEGF...

  11. The effect of factor XIII on bleeding in coronary surgery.

    Science.gov (United States)

    Gödje, O; Haushofer, M; Lamm, P; Reichart, B

    1998-10-01

    One cause of diffuse bleeding after cardiac operations may be a low plasma concentration of Factor XIII, which is essential for coagulation, but is not covered by standard coagulation monitoring. In a prospective pilot study, Factor XIII levels before and after extracorporeal circulation were investigated, and drain volumes and blood transfusions of a control group of 11 patients were compared with a group of 11 patients who received 2500 units Factor XIII postoperatively. Factor XIII fell significantly from preoperative values of 96.1% and 88.7% (control) to 55.7% and 51.8% (control) postoperatively. By administration of Factor XIII, plasma level rose significantly from 55.7% to 103.1%; in the control group the value remained low. Drain volumes on the first and second postoperative day were significantly lower in the Factor XIII group. In the control group 1.9 units of red blood cells and 1.6 units fresh frozen plasma were administered, in the Factor XIII group 0.9 and 0.6 units were necessary. Factor XIII influences bleeding after coronary surgery and can reduce the need for blood transfusions. In patients with prolonged diffuse bleeding, we therefore recommend substitution of Factor XIII.

  12. Classical elements in the endowments of Serbian XIII century donors

    OpenAIRE

    Gligorijević-Maksimović Mirjana

    2009-01-01

    In Byzantine painting, starting from the XIII and particularly during the XIV century, there was a visible return to models from the period of Antiquity. The influences of ancient, ostensibly, Hellenistic heritage were reflected in the shapes, in the content of the compositions, as well as in the drawing, modellation and colours. In the art that came into being in the course of the XIII century, in the endowments of the Serbian donors numerous elements emerged that had existed in ancient art....

  13. Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.

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    Michael Kraeussling

    Full Text Available In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT. Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.

  14. 4p-5s transitions in In XIII, In XIV and In XV

    International Nuclear Information System (INIS)

    Carroll, P.K.; Costello, J.T.; O'Sullivan, G.

    1986-01-01

    The spectrum of an indium plasma produced by a 1.5 J, 25 ns ruby laser was recorded in the XUV. At wavelengths below 100 A, the spectrum is dominated by 4p-5s transitions in a number of ion stages. Many lines arising from 4p 6 4d-4p 5 4d5s, 4p 6 -4p 5 5s and 4p 5 -4p 4 5s transitions in In XIII, In XIV and In XV have been identified by isoelectronic extrapolation and Dirac-Fock calculations. (orig.)

  15. Modern Trends in Inorganic Chemistry (MTIC-XIII)

    Indian Academy of Sciences (India)

    MAC 10

    Symposium on Modern Trends in Inorganic Chemistry (MTIC-XIII) held at the Indian. Institute of Science, Bangalore during December 7–10, 2009. The MTIC series of symposia (held once in two years) have emerged as a primary forum for the scientific fraternity of the country to focus on the current status and future ...

  16. Modern Trends in Inorganic Chemistry (MTIC-XIII)

    Indian Academy of Sciences (India)

    MAC 10

    This Special Issue is based on the invited lectures delivered at the Thirteenth. Symposium on Modern Trends in Inorganic Chemistry (MTIC-XIII) held at the Indian. Institute of Science, Bangalore during December 7–10, 2009. The MTIC series of symposia (held once in two years) have emerged as a primary forum for the ...

  17. Factor xiii deficiency in children-clinical presentation and outcome

    International Nuclear Information System (INIS)

    Fadoo, Z.; Saleem, A.F.

    2008-01-01

    To determine the demographic features and clinical outcome of children with Factor XIII deficiency. Records of all hospitalized pediatric patients with discharge diagnosis of FXIII D, on the basis of factor XIII assay 5 mol/L urea test were retrospectively reviewed and abstracted on a pre-specified proforma. Demographic features, coagulation profile, family history and outcomes were noted. A total of 10 charts were reviewed. There were 5 boys and 5 girls. Almost all the children (9/10) were less than 5 years of age, out of whom 5 (50%) were infants, and 3 were neonates. Bruises and prolonged bleeding after trauma was the major presenting complaints in 80%, followed by prolonged bleeding from the umbilical stump in 2 patients. Nine patients had past history of prolonged umbilical bleeding. Two patients had history of FXIII D in siblings, while 2 had history of prolonged bleeding in other family members (cause unknown). Consanguinity was present in 80% of the families. Initial coagulation screen were normal in all patients. Two patients had intracranial hemorrhage, proved on neuro-imaging, were managed with plasma infusions and required craniotomy. The rest were managed conservatively with plasma transfusions. All were discharged alive in good clinical condition. Almost all were followed regularly in clinic with monthly cryoprecipitate transfusions. Although factor XIII deficiency is a rare genetic disorder in children with history of bruising, prolonged umbilical bleeding, family history of bleeding and consanguinity with normal initial coagulation screen (PT, APTT and platelets), FXIII D should be ruled out. (author)

  18. 40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units XIII Appendix XIII to Part 266 Protection of Environment... XIII to Part 266—Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units These...

  19. Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division

    KAUST Repository

    Robertson, Anthony J.

    2013-03-25

    In animal development following the initial cleavage stage of embryogenesis, the cell cycle becomes dependent on intercellular signaling and controlled by the genomically encoded ontogenetic program. Runx transcription factors are critical regulators of metazoan developmental signaling, and we have shown that the sea urchin Runx gene runt-1, which is globally expressed during early embryogenesis, functions in support of blastula stage cell proliferation and expression of the mitogenic genes pkc1, cyclinD, and several wnts. To obtain a more comprehensive list of early runt-1 regulatory targets, we screened a Strongylocentrotus purpuratus microarray to identify genes mis-expressed in mid-blastula stage runt-1 morphants. This analysis showed that loss of Runx function perturbs the expression of multiple genes involved in cell division, including the pro-growth and survival kinase Akt (PKB), which is significantly underexpressed in runt-1 morphants. Further genomic analysis revealed that Akt is encoded by two genes in the S. purpuratus genome, akt-1 and akt-2, both of which contain numerous canonical Runx target sequences. The transcripts of both genes accumulate several fold during blastula stage, contingent on runt-1 expression. Inhibiting Akt expression or activity causes blastula stage cell cycle arrest, whereas overexpression of akt-1 mRNA rescues cell proliferation in runt-1 morphants. These results indicate that post-cleavage stage cell division requires Runx-dependent expression of akt.

  20. Classical elements in the endowments of Serbian XIII century donors

    Directory of Open Access Journals (Sweden)

    Gligorijević-Maksimović Mirjana

    2009-01-01

    Full Text Available In Byzantine painting, starting from the XIII and particularly during the XIV century, there was a visible return to models from the period of Antiquity. The influences of ancient, ostensibly, Hellenistic heritage were reflected in the shapes, in the content of the compositions, as well as in the drawing, modellation and colours. In the art that came into being in the course of the XIII century, in the endowments of the Serbian donors numerous elements emerged that had existed in ancient art. In the frescoes in the Church of the Mother of God in Studenica, the endowment of Stefan Nemanja and his sons, we see personifications, symbols, the introduction of details, and space acquiring depth, features that were later to come to full expression, especially from the middle of the XIII century. The few preserved frescoes dating from the XIII century in the Church of the Resurrection in the Žiča monastery, the endowment of Stefan the First Crowned, his son Radoslav and his brother Sava, are an iconographic continuation of the trends in the art one encounters in Studenica. The frescoes in the Church of Christ's Ascension in Mileševa, the endowment of King Vladislav, with their subtly fashioned figures and carefully modelled faces, as well as refined colouring, signal a return to the Hellenistic models. The painting in the Church of Dormition of the Virgin in the Morača monastery, the endowment of Prince Stefan, nephew of king Stefan, with its well-proportioned, firmly modelled figures, landscapes and architecture deepening the space, reminds one of the Sopoćani frescoes. In the fresco painting of the Holy Apostles in Peć, the endowment of Archbishop Sava which owed its outcome to the efforts of Archbishop Arsenije I, the images are very vivid, and the painted architecture is depicted in an abbreviated form, using different kinds of perspective. The painting in the Church of the Holy Trinity in Sopoćani, the endowment of king Uroš I, represents

  1. Systemic and intestinal levels of factor XIII-A

    DEFF Research Database (Denmark)

    Søndergaard, Christoffer; Kvist, Peter Helding; Seidelin, Jakob Benedict

    2016-01-01

    , indicating a reduction of the M2 phenotype with consequent loss of FXIII-A. No induction of iNOS positive macrophages was observed. Stimulation of naïve monocytes with physiological concentrations of pro-inflammatory mediators negatively affected the expression of FXIII-A. Measurements in plasma confirmed...... the loss of both FXIII antigen and activity during active disease. CONCLUSIONS: Intestinal inflammation in UC induces loss of M2 macrophages with subsequent loss of FXIII-A synthesis. The loss of cellular FXIII-A may impact migration and phagocytosis, and hence limit pathogen eradication in UC.......BACKGROUND: Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages...

  2. Tactic "Tulgama" the Art of War the Mongols XIII century

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    Leonid A. Bobrov

    2015-12-01

    Full Text Available In this publication, based on a comprehensive analysis of the sources, considered one of the most important tactics of the Mongols of the XIII century, known under the Turkic name "Tulgama". The name of the maneuver is derived from the Turkic verb "talamak", meaning "to surround, to wrapped up, to turn, to whirl, to twist". It is established that the maneuver "Tulgama" was a special tactic, providing coverage flank (flanks of the enemy in the rear and the application of massed archery shot in his builds. Selected three varieties under consideration tactic: right flank or left flank and steam room (double "Tulgama". The most typical was right flanks "Tulgama" when doing the nomads, covered the left wing of the enemy with its right flank. This allowed the attacking archers to fire from the most convenient position (left-forward, left, and left-back. A characteristic feature of the Mongol tactical art was a steam room (double "Tulgama" when the troops of nomads covered both enemy's flank, concluding the enemy's army in the ring, then attacked her from all four sides. A similar technique could not only shoot down from the position, but almost completely destroy the enemy troops. For the most efficient use of maneuver "Tulgama" the Mongols made increasing use of expanded mesalamines system, with a powerful thrust forward flank groups. The concentration of the shock troops on the flanks (reinforced, including by weakening the Central shelf is dramatically different from the tactics of the Mongols from the traditional tactics of the Turks, whose best part was typically the center of the combat formations. However, direct confrontation of these two approaches during the military campaigns of the XIII century demonstrated the advantages of the Mongol tactical schemes. High efficiency of reception "Tulgama" led to its continued existence in the military art of the nomads.

  3. Plague Epidemic s in Syria b etween XIII - XV. Centuries

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    Esra ATMACA

    2015-07-01

    Full Text Available Epidemic diseases that cause mass death has been one of the greatest fears of the society in the past century Usually due to poor living conditions, poverty, the inadequate treatment. Plague is one of them. Plague word is sometimes used synonymously with t he word tâûn, sometimes considered to be a greater sense of the Word plague. These outbreaks occured repeatedly in human society and many times occured between XIII - XV. centuries. Our research aims to examine the plague occured in Syria in the Mamluk state domination discussed period. One of the outbreaks have occured in the period between the years 1347 - 1351. Epidemic was looming at the same time with the European named the black death or large extinction. Many people have been killed in Syria as in other places where the epidemic has spread. Rumors about them are given in the source is situated in the form of the issuance of the number of people who died in one day and sometimes the total number of deaths took place at a given date range. In this study, we aimed to determine which is more severe than the others in the outbreak, to assess the rumor about the number of deaths from this cause, to reveal the difficulties of the funeral of the dead, to uncover practices that people do to get rid of this disease.

  4. Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function

    Energy Technology Data Exchange (ETDEWEB)

    Muszbek, L.; Adany, R. [Univ. Medical School of Debrecen (Hungary); Mikkola, H. [Univ. of Helsinki (Finland)

    1996-10-01

    Blood coagulation factor XIII (FXIII) is a protransglutaminase that becomes activated by the concerted action of thrombin and Ca{sup 2+} in the final stage of the clotting cascade. In addition to plasma, FXIII also occurs in platelets, monocytes, and monocyte-derived macrophages. While the plasma factor is a heterotetramer consisting of paired A and B subunits (A{sub 2}B{sub 2}), its cellular counterpart lacks the B subunits and is a homodimer of potentially active A subunits (A{sub 2}). The gene coding for the A and B subunits has been localized to chromosomes 6p24-25 and 1q31-32.1, respectively. The genomic as well as the primary protein structure of both subunits has been established. Plasma FXIII circulates in association with its substrate precursor, fibrinogen. Fibrin(ogen) has an important regulatory role in the activation of plasma FXIII, for instance the proteolytic removal of activation peptide by thrombin, the dissociation of subunits A and B, and the exposure of the originally buried active site on the free A subunits. The end result of this process is the formation of an active transglutaminase, which crosslinks peptide chains through {epsilon}({gamma}-glutamyl)lysyl isopeptide bonds. The protein substrates of activated FXIII include components of the clotting-fibrinolytic system, adhesive and contractile proteins. The main physiological function of plasma FXIII is to cross-link fibrin and protect it from the fibrinolytic enzyme plasmin. The latter effect is achieved mainly by covalently linking {alpha}{sub 2} antiplasmin, the most potent physiological inhibitor of plasmin, to fibrin. Plasma FXIII seems to be involved in wound healing and tissue repair, and it is essential to maintaining pregnancy. Cellular FXIII, if exposed to the surface of the cells, might support or perhaps take over the hemostatic functions of plasma FXIII; however, its intracellular role has remained mostly unexplored. 328 refs., 4 figs.

  5. Factor XIII stiffens fibrin clots by causing fiber compaction.

    Science.gov (United States)

    Kurniawan, N A; Grimbergen, J; Koopman, J; Koenderink, G H

    2014-10-01

    Factor XIII-induced cross-linking has long been associated with the ability of fibrin blood clots to resist mechanical deformation, but how FXIII can directly modulate clot stiffness is unknown. We hypothesized that FXIII affects the self-assembly of fibrin fibers by altering the lateral association between protofibrils. To test this hypothesis, we studied the cross-linking kinetics and the structural evolution of the fibers and clots during the formation of plasma-derived and recombinant fibrins by using light scattering, and the response of the clots to mechanical stresses by using rheology. We show that the lateral aggregation of fibrin protofibrils initially results in the formation of floppy fibril bundles, which then compact to form tight and more rigid fibers. The first stage is reflected in a fast (10 min) increase in clot stiffness, whereas the compaction phase is characterized by a slow (hours) development of clot stiffness. Inhibition of FXIII completely abrogates the slow compaction. FXIII strongly increases the linear elastic modulus of the clots, but does not affect the non-linear response at large deformations. We propose a multiscale structural model whereby FXIII-mediated cross-linking tightens the coupling between the protofibrils within a fibrin fiber, thus making the fiber stiffer and less porous. At small strains, fiber stiffening enhances clot stiffness, because the clot response is governed by the entropic elasticity of the fibers, but once the clot is sufficiently stressed, the modulus is independent of protofibril coupling, because clot stiffness is governed by individual protofibril stretching. © 2014 International Society on Thrombosis and Haemostasis.

  6. EDITORIAL: XIII Mexican Workshop on Particles and Fields

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    Barranco, Juan; Contreras, Guillermo; Delepine, David; Napsuciale, Mauro

    2012-08-01

    Juan Barranco Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) jbarranc@fisica.ugto.mx Guillermo Contreras Departamento de Fisica Aplicada Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Merida (Mexico) jgcn@mda.cinvestav.mx David Delepine Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) delepine@fisica.ugto.mx Mauro Napsuciale Physics Department, Guanajuato University, Loma del Bosque 103, col. Loma del Campestre, 37150, Leon (Mexico) mauro@fisica.ugto.mx The XIII Mexican Workshop on Particles and Fields (MWPF) took place from 20-26 October 2011, in the city of León, Guanajuato, México. This is a biennial meeting organized by the Division of Particles and Fields of the Mexican Physical Society designed to gather specialists in different areas of high energy physics to discuss the latest developments in the field. The thirteenth edition of this meeting was hosted by the Department of Cultural Studies of Guanajuato University in a nice environment dedicated to the Arts and Culture. The XIII MWPF was organized by three working groups who organized the corresponding sessions around three topics. The first one was Strings, Cosmology, Astroparticles and Physics Beyond the Standard Model. In this category we included: Cosmic Rays, Gamma Ray Bursts, Physics Beyond the Standard Model (theory and experimental searches), Strings and Cosmology. The working group for this topic was formed by Arnulfo Zepeda, Oscar Loaiza, Axel de la Macorra and Myriam Mondragón. The second topic was Hadronic Matter which included Perturbative QCD, Jets and Diffractive Physics, Hadronic Structure, Soft QCD, Hadron Spectroscopy, Heavy Ion Collisions and Soft Physics at Hadron Colliders, Lattice Results and Instrumentation. The working group for this topic was integrated by Wolfgang Bietenholz and Mariana Kirchbach. The third topic was

  7. Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers

    NARCIS (Netherlands)

    Franco, R. F.; Middeldorp, S.; Meinardi, J. R.; van Pampus, E. C.; Reitsma, P. H.

    2000-01-01

    A mutation in factor XIII (Val34Leu) was reported to protect against venous thromboembolism. We evaluated the effect of Val34Leu on thrombotic risk in 352 factor V Leiden carriers who were first-degree relatives of 132 thrombotic propositi carrying factor V Leiden. The total observation period was

  8. Factor XIII Va134Leu and the risk of venous thromboembolism in factor V Leiden carriers

    NARCIS (Netherlands)

    Franco, RF; Middeldorp, S; Meinardi, [No Value; van Pampus, ECM; Reitsma, PH

    2000-01-01

    A mutation in factor XIII (Val34Leu) was reported to protect against Venous thromboembolism. We evaluated the effect of Val34Leu on thrombotic risk in 352 factor V Leiden carriers who were first-degree relatives of 132 thrombotic propositi carrying factor V Leiden. The total observation period was

  9. Characterization of carbonic anhydrase XIII in the erythrocytes of the Burmese python, Python molurus bivittatus.

    Science.gov (United States)

    Esbaugh, A J; Secor, S M; Grosell, M

    2015-09-01

    Carbonic anhydrase (CA) is one of the most abundant proteins found in vertebrate erythrocytes with the majority of species expressing a low activity CA I and high activity CA II. However, several phylogenetic gaps remain in our understanding of the expansion of cytoplasmic CA in vertebrate erythrocytes. In particular, very little is known about isoforms from reptiles. The current study sought to characterize the erythrocyte isoforms from two squamate species, Python molurus and Nerodia rhombifer, which was combined with information from recent genome projects to address this important phylogenetic gap. Obtained sequences grouped closely with CA XIII in phylogenetic analyses. CA II mRNA transcripts were also found in erythrocytes, but found at less than half the levels of CA XIII. Structural analysis suggested similar biochemical activity as the respective mammalian isoforms, with CA XIII being a low activity isoform. Biochemical characterization verified that the majority of CA activity in the erythrocytes was due to a high activity CA II-like isoform; however, titration with copper supported the presence of two CA pools. The CA II-like pool accounted for 90 % of the total activity. To assess potential disparate roles of these isoforms a feeding stress was used to up-regulate CO2 excretion pathways. Significant up-regulation of CA II and the anion exchanger was observed; CA XIII was strongly down-regulated. While these results do not provide insight into the role of CA XIII in the erythrocytes, they do suggest that the presence of two isoforms is not simply a case of physiological redundancy. Copyright © 2015. Published by Elsevier Inc.

  10. Incorporation of 3H-thymidine during early developmental stages of ovoviviparous and oviparous embryos in the brine

    International Nuclear Information System (INIS)

    Iwasaki, Tamiko

    1980-01-01

    DNA synthesis in the embryos during various developmental stages in the brood pouch of the Artemia female as well as the encysted eggs produced by oviparity was studied by autoradiography using 3 H-thymidine. Nuclei of the embryos through the blastula stage in the brood pouch were labelled, regardless of the existence of the thick shell surrounding the embryos. However, incorporation of 3 H-thymidine into nuclei was absent in the stages between gastrula and early nauplii which had developed in the brood pouch or were delivered from encysted dry eggs. (author)

  11. Analisis Produksi USAha Pengasapan Ikan Di Desa Koto Mesjid Kecamatan XIII Koto Kampar Kabupaten Kampar

    OpenAIRE

    Sari, Yesi Purmita; ', Harlen; Harahap, Azwar

    2017-01-01

    The purpose of this research is to know the capital, raw materials and labor effect of positive and negative factors of production and to know what is the most dominant affect of curring fish industrial production at Koto Mesjid Kampar XIII District of Kampar.The population in this research is the whole industry entrepeneur fogging producing smoked fish/ fish salai in the village of Koto Mesjid that addup to 10 industry. Sampling techniques in the study using census by taking the whole of cur...

  12. Spontaneous rupture of the spleen in Factor XIII deficiency: A report of two cases

    International Nuclear Information System (INIS)

    Bhan, Pankaj; Al-Hilli, Shatha

    2010-01-01

    Spontaneous rupture of spleen due to factor XIII defieciency is a rare cause of abdominal pain with disastrous consequences and can be easily confused with other abdominal pathologies until a strong possibility is entertained.The patients usually present in emergengy with acute abdomen and diagnosis is difficult.The diagnosis is usually made on high degree of clinical suspicion and falling hematorit and failure of conservative management or by imaging. The radiologist need to be aware of this potentially fatal complication since early intervention is life saving. CT imaging can also help in conservative management in non critical patients

  13. L'escriptura i el llibre a la Catalunya Central als segles XIII i XIV

    OpenAIRE

    Torras i Cortina, Miquel

    2004-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Aquesta investigació reconstrueix la vida cultural de la ciutat de Manresa, a la Catalunya Central, al llarg dels segles XIII i XIV, amb el còdex baixmedieval com a fil conductor. L'estudi es basa en l'anàlisi de 305 documents amb mencions libràries (editats conjuntament), pràcticament tots ells inèdits, que procedeixen d'un buidatge exhaustiu dels fons notarials que custodien l'Arxiu Històric Comarcal de Manresa i l'Arx...

  14. Oxygen consumption rate and Na+/K+-ATPase activity in early developmental stages of the sea urchin Paracentrotus lividus Lam.

    Science.gov (United States)

    Tomšić, Sanja; Stanković, Suzana; Lucu, Čedomil

    2011-09-01

    Changes in oxygen consumption rate and Na+/K+-ATPase activity during early development were studied in the sea urchin Paracentrotus lividus Lam. The oxygen consumption rate increased from 0.12 μmol O2 mg protein-1 h-1 in unfertilized eggs to 0.38 μmol O2 mg protein-1 h-1 25 min after fertilization. Specific activity of the Na+/K+-ATPase was significantly stimulated after fertilization, ranging up to 1.07 μmol Pi h-1 mg protein-1 in the late blastula stage and slightly lower values in the early and late pluteus stages.

  15. Red portuaria y control marítimo en el reino de Valencia (siglos XIII-XV)

    OpenAIRE

    Igual Luis, David

    2013-01-01

    El trabajo aborda la progresiva creación de una red portuaria en el litoral valenciano de los siglos XIII-XV y, a partir de ella, el desarrollo de diversos instrumentos de control marítimo que atendían a principios políticos, legales, infraestructurales y hasta territoriales.

  16. Proceedings of the XIII International Symposium on Biological Control of Weeds; September 11-16, 2011; Waikoloa, Hawaii, USA

    Science.gov (United States)

    Yun Wu; Tracy Johnson; Sharlene Sing; S. Raghu; Greg Wheeler; Paul Pratt; Keith Warner; Ted Center; John Goolsby; Richard Reardon

    2013-01-01

    A total of 208 participants from 78 organizations in 19 countries gathered at the Waikoloa Beach Marriott on the Big Island of Hawaii on September 11-16, 2011 for the XIII International Symposium on Biological Control of Weeds. Following a reception on the first evening, Symposium co-chairs Tracy Johnson and Pat Conant formally welcomed the attendees on the morning of...

  17. Emerging variant of genotype XIII Newcastle disease virus from Northeast India.

    Science.gov (United States)

    Nath, Barnali; Kumar, Sachin

    2017-08-01

    Northeast India with its rich and diverse avifauna acts as a hotbed for emerging virulent Newcastle disease virus (NDV) strains. The present work describes the molecular and pathogenic characterization of NDV strain isolated from Pandu, Assam, India. Clinicopathological and genetic analysis showed the virulent nature of NDV strain Pandu. On molecular phylogenetic and evolutionary distance analysis, the NDV strain Pandu formed a distinct clade within the genotype XIII of class II NDV, suggesting a new sub-genotype XIIIc. The accumulation of mutations in the NDV strain Pandu makes it divergent enough to be considered as a new sub-genotype. The proposed NDV sub-genotype XIIIc consists of strains recently reported from eastern and northeastern India. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

    Directory of Open Access Journals (Sweden)

    Vaida Morkūnaitė

    2014-01-01

    Full Text Available A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA and isothermal titration calorimetry (ITC. Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs.

  19. An experimental approach to manufacturing technology of historical glass (XIII-XV centuries). Comparison with current glassmaking technology.

    Science.gov (United States)

    Tarrago, Mariona; Gimeno, Domingo; Bazzocchi, Flavia; Garcia-Valles, Maite; Martinez, Salvador

    2015-04-01

    One of the major and less explored issues in the characterization of historical glasses is the determination of their viscosity as a function of temperature in order to constrain technological aspects of glass production. Until now, assumptions on temperatures have been based on mathematical models based on chemical compositions. Hence, the topic of this work is to explore the technology of stained glass production related to the workability and melting process of the glass by experimental laboratory measurements. This work presents the analysis of viscosity of glasses from different historical sites and chemical compositions: four from Santes Creus (Tarragona, XIII century), two of classical medieval stained glass window from Santa Maria de Pedralbes (Barcelona, mid XIV century), and three of evolved late-medieval type from Santa Maria del Mar (Barcelona first half of XV century), and one sample of soda-lime industrial glass by means of Hot-Stage Microscopy and glass transformation temperature Tg by dilatometry. These data are then compared to the predictions on theoretical viscosity obtained from mathematical models based on chemical composition. These samples are classified according to their major modifier in: Na-rich (12-17% of Na2O, between 65-77% of SiO2 and less than 3 % of K2O); Ca-rich (29% of CaO, 54% of SiO2, 4% of K2O, and 4% of Na2O); K-Ca-rich (17 to 21% of K2O, more than 14% of CaO, 49-55% of SiO2and less than 2% of Na2O); Na-Ca-rich (12-14% of Na2O, 9-15% of CaO, 57-71% of SiO2 and process (melting, working, conditioning and annealing ranges). These results are also compared to mathematical models of glass viscosity based on chemical composition. The annealing range (viscosity between 1013.5 and 1012 Pa-s) is reached at temperatures between 484-633°C (strain point) and 509-664°C (upper limit). The working point (viscosity of 103 Pa-s) has temperature values in the range between 958 and 1097°C.

  20. Who was the Red Queen? Identity of the female Maya dignitary from the sarcophagus tomb of Temple XIII, Palenque, Mexico.

    Science.gov (United States)

    Tiesler, V; Cucina, A; Pacheco, A Romano

    2004-01-01

    The present investigation aims at contributing to the ongoing discussion on the unconfirmed identity of the Red Queen, a Classic Maya dignitary discovered in Temple XIII at Palenque, Mexico, by comparing her reconstructed facial profile to the portraiture of known female personages from the site. The comparison rests upon individual cranial features, like buccal prognatism, nasal root and inclination, chin prominence and the artificially shaped forehead. The similarities between the reconstruction, the female's funerary mask and local portraiture appear to identify the Red Queen as Lady Ix Tz'akb'u Ajaw (Ahpo Hel), the wife of Janaab' Pakal, one of the famous Maya rulers of the Classic Period. The proposed match and her family relationship with the king might explain the spatial closeness of their burial places in the Temple of the Inscriptions and Temple XIII.

  1. I governi di “popolo” e le istituzioni comunali nella seconda metà del secolo XIII

    Directory of Open Access Journals (Sweden)

    Enrico Artifoni

    2003-12-01

    Full Text Available Nella seconda metà del secolo XIII la cultura politica dei governi popolari si esprime in modo articolato e consapevole attraverso molteplici scelte: l’istituzione di organismi collegiali ristretti, la valorizzazione delle forme associative di quartiere o di rione, la “domanda” rivolta al ceto notarile di elaborare forme documentarie adeguate a un assetto istituzionale complesso qual era quello del comune duecentesco.

  2. Del "scriptor" al "publicus notarius" : los escribanos de Madrid en el siglo XIII

    Directory of Open Access Journals (Sweden)

    María Teresa Carrasco Lazareno

    2003-01-01

    Full Text Available Estudio diplomático y jurídicoinstitucional de las escribanías de Madrid en el siglo XIII. Se analiza su evolución desde los primeros "Scriptores» prenotariales conocidos, clérigos y laicos de libre profesión, documentados hasta 1260, hasta la consolidación definitiva de la institución notarial y del instrumento público en el último cuarto del siglo XIII. Se estudian con detenimiento la compleja etapa de transición, en las décadas centrales de la centuria, la figura del «escrivano de congejo de Madrit», profesional estable y antecedente inmediato del escribano público, y la instauración del notariado, de acuerdo con la legislación alfonsina, así como de la escribanía municipal, por otorgamiento de Alfonso X, en 1264. A través de la documentación conservada, se analiza, asimismo, la transformación de la simple carta o «scriptura» testifical en «publicum instrumentum», mediante la valoración de la pervivencia de elementos tradicionales y la aparición de fórmulas diplomáticas que revelan la paulatina introducción.This is a diplomatic and a legal — institutional study about the actuarles offices in Madrid during the Xlllth century Its evolution is analyzed from the first known prenotarial "scriptores», priests and liberal professionals seculars, documented until 1260, until the final consolidation of the notary institution and the public instrument during the last quarter of the Xlllth century There is a detailed study about the complexity of the transitional period, during the central decades of that century, the figure of the «Notary of the Madrid Town Council», as a stable professional and immediate predecessor of the public actuary the establishment of the body of actuarles, according to the Alphonsine legislation, an the municipal actuary office, established by King Alphonse Xth., in 1264. Through the preserved documentation, it is analized, at the same time, the transformation of the simple letter, or

  3. Identidad de las hospitalarias en la corona de Aragón (siglos XII-XIII

    Directory of Open Access Journals (Sweden)

    Maria Bonet Donato

    2014-12-01

    Full Text Available La rama femenina del Hospital fue singular en el seno de la institución y logró una autonomía y una entidad diferenciadora que se manifestó y consolidó en la afirmación de elementos identitarios. La identidad de las hospitalarias se concretó en la reivindicación y el despliegue de funciones y actividades singulares, en la existencia de mujeres carismáticas que encarnaron dicha identidad y en el reconocimiento de ciertos espacios. Las comunidades de monjas hospitalarias de la corona de Aragón en los siglos XII y XIII se caracterizaron por una diferenciación entre ellas mayor que la que se dio entre las encomiendas masculinas, y a su vez tuvieron mayor individualización en el contexto institucional. Las hospitalarias expresaron su espiritualidad y lograron visibilidad y protagonismo social, conforme a la creación o recreación de la identidad hospitalaria. Dicha identidad femenina hospitalaria resultó de la combinación de aspectos concernientes a la identidad familiar, femenina, espiritual, religiosa, individual, política, y se acomodó a la “personalidad” de cada entidad conventual, e inclusive a la de algunas figuras con destacado liderazgo

  4. Tres Violantes: las mujeres de una familia en el poder a lo largo del siglo XIII

    Directory of Open Access Journals (Sweden)

    Fuente Pérez, María Jesús

    2016-06-01

    Full Text Available The power of women, in particular the power of queens, has been a topic of great interest to historians, medievalists in particular; though much has been written about the subject, many questions remain. “Three Violantes” will look at the role of two Iberian queens and one Spanish princess in the thirteenth century Iberian kingdoms. In England and in other European kingdoms of that time, queens had lost authority and their agency was limited to the power of intercession and mediation, I will try to determine whether this also holds true for the Iberian queens.El interés por el tema del poder de las mujeres, en particular de las reinas, ha planteado muchos interrogantes sobre la naturaleza de ese poder. “Tres Violantes” examina la participación de dos reinas y una infanta de una misma familia, en aspectos diversos de la vida de las coronas de Aragón y Castilla en el siglo XIII, con el objetivo de apreciar si el papel de las reinas hispanas, en particular su participación política, siguió un camino similar al de las reinas de ese tiempo que, como bien se ha estudiado para las inglesas, fueron perdiendo autoridad y se vieron limitadas a ejercer poder a través de la intercesión y mediación.

  5. Safety of Factor XIII Concentrate: Analysis of More than 20 Years of Pharmacovigilance Data

    Science.gov (United States)

    Solomon, Cristina; Korte, Wolfgang; Fries, Dietmar; Pendrak, Inna; Joch, Christine; Gröner, Albrecht; Birschmann, Ingvild

    2016-01-01

    Background Plasma-derived factor XIII (FXIII) concentrate is an effective treatment for FXIII deficiency. We describe adverse drug reactions (ADRs) reported during pharmacovigilance monitoring of Fibrogammin®/Corifact® and review published safety data. Methods Postmarketing safety reports recorded by CSL Behring from June 1993 to September 2013 were analyzed. Clinical studies published during the same period were also reviewed. Results Commercial data indicated that 1,653,450,333 IU FXIII concentrate were distributed over the review period, equivalent to 1,181,036 doses for a 70 kg patient. 75 cases were reported (one/15,700 standard doses or 22,046,000 IU). Reports of special interest included 12 cases of possible hypersensitivity reactions (one/98,400 doses or 137,787,500 IU), 7 with possible thromboembolic events (one/168,700 doses or 236,207,200 IU), 5 of possible inhibitor development (one/236,200 doses or 330,690,100 IU), and 20 of possible pathogen transmission (one/59,100 doses or 82,672,500 IU). 19 pathogen transmission cases involved viral infection; 4 could not be analyzed due to insufficient data, but for all others a causal relationship to the product was assessed as unlikely. A review of published literature revealed a similar safety profile. Conclusion Assessment of ADRs demonstrated that FXIII concentrate carries a low risk of ADRs across various clinical situations, suggesting a favorable safety profile. PMID:27781024

  6. Ressenya a Ovidio Cuella Esteban i Juan B. Simó Castillo, Bulario de Benedicto XIII (1394-1423. VI. Diócesis de Tortosa. Maestrazgo de Santa María de Montesa. Testamento de Benedicto XIII, Peníscola, Associació ‘Amics del Papa Luna’, 2013, pp. 680, ISBN 978-84-616-7651-4

    Directory of Open Access Journals (Sweden)

    Blai Josep Server Server

    2014-12-01

    Full Text Available Review to Ovidio Cuella Esteban i Juan B. Simó Castillo, Bulario de Benedicto XIII (1394-1423. VI. Diócesis de Tortosa. Maestrazgo de Santa María de Montesa. Testamento de Benedicto XIII, Peníscola, Associació ‘Amics del Papa Luna’, 2013, pp. 680, ISBN 978-84-616-7651-4

  7. Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke.

    Science.gov (United States)

    Hanscombe, Ken B; Traylor, Matthew; Hysi, Pirro G; Bevan, Stephen; Dichgans, Martin; Rothwell, Peter M; Worrall, Bradford B; Seshadri, Sudha; Sudlow, Cathie; Williams, Frances M K; Markus, Hugh S; Lewis, Cathryn M

    2015-08-01

    Abnormal coagulation has been implicated in the pathogenesis of ischemic stroke, but how this association is mediated and whether it differs between ischemic stroke subtypes is unknown. We determined the shared genetic risk between 14 coagulation factors and ischemic stroke and its subtypes. Using genome-wide association study results for 14 coagulation factors from the population-based TwinsUK sample (N≈2000 for each factor), meta-analysis results from the METASTROKE consortium ischemic stroke genome-wide association study (12 389 cases, 62 004 controls), and genotype data for 9520 individuals from the WTCCC2 ischemic stroke study (3548 cases, 5972 controls-the largest METASTROKE subsample), we explored shared genetic risk for coagulation and stroke. We performed three analyses: (1) a test for excess concordance (or discordance) in single nucleotide polymorphism effect direction across coagulation and stroke, (2) an estimation of the joint effect of multiple coagulation-associated single nucleotide polymorphisms in stroke, and (3) an evaluation of common genetic risk between coagulation and stroke. One coagulation factor, factor XIII subunit B (FXIIIB), showed consistent effects in the concordance analysis, the estimation of polygenic risk, and the validation with genotype data, with associations specific to the cardioembolic stroke subtype. Effect directions for FXIIIB-associated single nucleotide polymorphisms were significantly discordant with cardioembolic disease (smallest P=5.7×10(-04)); the joint effect of FXIIIB-associated single nucleotide polymorphisms was significantly predictive of ischemic stroke (smallest P=1.8×10(-04)) and the cardioembolic subtype (smallest P=1.7×10(-04)). We found substantial negative genetic covariation between FXIIIB and ischemic stroke (rG=-0.71, P=0.01) and the cardioembolic subtype (rG=-0.80, P=0.03). Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype. © 2015 The

  8. Radiation protection in the 2000s - Theory and practice. Nordic Society for Radiation Protection. Proceedings of the XIII ordinary meeting

    International Nuclear Information System (INIS)

    Paile, W.

    2003-06-01

    The XIII ordinary meeting of the Nordic Society for Radiation Protection (NSFS) was held on August 25-29, 2002 in Turku (Aabo), Finland. The main topics included: protection of the environment, information and ethics, natural radiation, reactor safety and waste management, emergency preparedness, medical use of radiation, radiation in industrial use, education and certification, radiation biology and epidemiology, and radioecology and monitoring. The proceedings of the meeting includes all the papers of the oral presentations as well as the poster presentations. Papers presenting scientific results have been subject to a referee process with evaluation of independent experts

  9. O POBRE DE ASSIS: A CONSTRUÇÃO DE UMA MEMÓRIA DE SANTIDADE (SÉCULO XIII).

    OpenAIRE

    Duarte, Fernanda Amelia Leal Borges

    2016-01-01

    Esta dissertação apresenta uma pesquisa sobre a construção da representação da santidade e memória de São Francisco de Assis, iniciada no século XIII. A santidade atribuída ao santo foi construída inicialmente pela Ordem Franciscana entre os anos de 1220 e 1266. No primeiro momento, com o discurso de institucionalização da nova ordem monástica, sua principal característica era o trabalho social voltado ao meio urbano, com uma nova proposta de vivenciar o Evangelho na pobreza ...

  10. An uncovered XIII century icon: Particular use of organic pigments and gilding techniques highlighted by analytical methods

    Science.gov (United States)

    Daveri, Alessia; Doherty, Brenda; Moretti, Patrizia; Grazia, Chiara; Romani, Aldo; Fiorin, Enrico; Brunetti, Brunetto Giovanni; Vagnini, Manuela

    2015-01-01

    The restoration of a panel painting depicting a Madonna and Child listed as an unknown Tuscan artist of the nineteenth century, permitted the hidden original version, a XIII century Medieval icon to be uncovered. It is discovery provided the opportunity for an extensive in situ campaign of non-invasive analytical investigations by portable imaging and spectroscopic techniques (infrared, X-ray fluorescence and diffraction, UV-Vis absorption and emission), followed by aimed micro-destructive investigations (Raman and SEM-EDS). This approach permitted characterization of the original ground and paint layers by complementary techniques. Furthermore, this protocol allowed supplementary particularities of great interest to be highlighted. Namely, numerous original gilding techniques have been accentuated in diverse areas and include the use of surrogate gold (disulphur tin), orpiment as a further false gold and an area with an original silver rich layer. Moreover, pigments including azurite mixed with indigo have been non-invasively identified. Micro-invasive analyses also allowed the diagnosis of organic colorants, namely, an animal anthraquinone lake, kermes and an unusual vegetal chalcone pigment, possibly safflower. The identification of the latter is extremely rare as a painting pigment and has been identified using an innovative adaption to surface enhanced Raman techniques on a cross-section. The resulting data contributes new hypotheses to the historic and artistic knowledge of materials and techniques utilized in XIII century icon paintings and ultimately provides scientific technical support of the recent restoration.

  11. Frontera y órdenes militares en la Edad Media castellano-leonesa (siglos XII-XIII

    Directory of Open Access Journals (Sweden)

    Carlos de AYALA MARTÍNEZ

    2009-12-01

    Full Text Available RESUMEN: El estudio presenta una breve panorámica del papel de las órdenes militares castellano-leonesas en la formación y consolidación de la frontera del reino con el Islam en los siglos XII y XIII. Ese papel tiene una triple dimensión –militar, colonizadora y estrictamente política– y sólo es posible constatar su eficacia a raíz del afianzamiento territorial e institucional de las órdenes militares, es decir, a partir del primer tercio del siglo XIII.ABSTRACT: The survey presents a brief view of the Castillian-Leonese military order’s role in the formation and consolidation of the kingdom’s border with the Islam in the twelfth and thirteenth centuries. This role has a triple dimension –military, settler and strictly political– and it is only possible to show its efficiency from the territorial and institutional strengthening of the military orders, that is, from the first third of the thirteenth century.

  12. Las tesis de los filósofos del siglo XIII que afirmaron la existencia del intelecto agente

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    Sellés, Juan Fernando

    2008-06-01

    Full Text Available In this article we review the statements of relevant philosophers of the XIIIeme century supporting the existence of the human agent intellect. Three groups can be distinguished: I The universal hylemorphism (Alexander of Hales, John de la Rochelle, Mathew of Acquasparta; II The synthesis between the augustinianism and the aristhotelism (Peter Hispanus, Saint Bonaventura, John Peckham; III The purified and advanced aristotelism (Albert the Great, Thomas Aquinas, Ramon Llull.

    En este trabajo se revisan las tesis de relevantes filósofos del s. XIII que defendieron la existencia del intelecto agente en el hombre. En el trabajo se dividen en tres grupos a los pensadores: I Los que se suelen encuadrar dentro del llamado hilemorfismo universal (Alejandro de Hales, Juan de la Rochela y Mateo de Acquasparta. II La síntesis entre el agustinismo y el aristotelismo (Pedro Hispano, San Buenaventura, Juan Peckham. III El aristotelismo depurado y proseguido (San Alberto Magno, Sto. Tomás de Aquino, Ramón Llull.

  13. Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

    Directory of Open Access Journals (Sweden)

    Tobias D Schneider

    Full Text Available Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative fluctuations in bulk histone modifications during development. To investigate this issue we analysed histones isolated from four different developmental stages of Xenopus laevis by mass spectrometry. In toto, we quantified 59 modification states on core histones H3 and H4 from blastula to tadpole stages. During this developmental period, we observed in general an increase in the unmodified states, and a shift from histone modifications associated with transcriptional activity to transcriptionally repressive histone marks. We also compared these naturally occurring patterns with the histone modifications of murine ES cells, detecting large differences in the methylation patterns of histone H3 lysines 27 and 36 between pluripotent ES cells and pluripotent cells from Xenopus blastulae. By combining all detected modification transitions we could cluster their patterns according to their embryonic origin, defining specific histone modification profiles (HMPs for each developmental stage. To our knowledge, this data set represents the first compendium of covalent histone modifications and their quantitative flux during normogenesis in a vertebrate model organism. The HMPs indicate a stepwise maturation of the embryonic epigenome, which may be causal to the progressing restriction of cellular potency during development.

  14. Of decentralization of public power Ukrainian land that belonged to Lithuanian (XIII – the early XVII century

    Directory of Open Access Journals (Sweden)

    C. V. Manuilova

    2016-06-01

    Full Text Available A comprehensive crisis in Ukraine and continued military confrontation in the Donbass demonstrated the urgent need to establish effective governance, which would imply decentralization of public power. Note that in implementing the decentralization of power in Ukraine insists the International Monetary Fund; United Nations Development Program; the transfer of authority to the field and decentralization of power in Ukraine is one of the points of the Minsk agreements and obligations of Ukraine to the EU. The article deals with the Ukrainian lands topical issue features the decentralization of public power in the XIII - the beginning of XVII century. The importance of the topic due to the need to study the historical experience of the implementation of decentralization. It was, emphasized that the success of the reforms depends largely because of the historical experience and features of the decentralization of public power in the past. Characterized by the development of local government in the Ukrainian lands was part of the Lithuanian state. The purpose of the article is to clarify the characteristics of decentralization of public authority on Ukrainian lands were part of the Lithuanian state during the XVII century XIII. To address this goal, outline decentralization of public power in the state; analyze, competence of local government in the Ukrainian lands that belonged to the Lith uanian State; determine how close to the power of the people. The level of decentralization of public power in the Grand Duchy of Lithuania in the XIII - the beginning of XVII century was high. It was, found that Lithuania had not established a centralized state. It is, noted that the Board of the nobility limited the princely power. The effect of delegated deputies from different parts of the Lithuanian statehood solutions nobility Council.Clarified the facts that confirm the existence of decentralization of public power in Lithuania: the functioning of local

  15. The Asamblea del Año XIII in the Rio de la Plata: Eternal Laurels to End the Revolution

    Directory of Open Access Journals (Sweden)

    Esteban Buch

    2016-09-01

    Full Text Available The Asamblea del año XIII, the 1813 Constitutional Assembly in the Río de la Plata, represents at its best revolutionary velocity, with its allegro rhythm towards wider liberties and a more perfect equality, towards an independence of the nation that, without being officially declared, inspires many of its gestures, like the creation of Argentina’s national anthem. A contemporary observer fond of anachronisms might find in it a confirmation that movement is an essential element of democracy. Yet, this dynamic perception should be balanced by reminding that the Assembly’s main project is not to accelerate the revolution, but to terminate it. “Close the period of the revolution, open the epoch of peace and freedom”, says its inaugural declaration. This paper focuses on the tension between these two conceptions of historical temporality.

  16. Proceedings of VII International Symposium on Nuclear and Related Techniques. XIII Workshop on Nuclear Physics. WONP-NURT 2011

    International Nuclear Information System (INIS)

    2011-02-01

    This year the XIII Workshop on Nuclear Physics (WONP) and the VII Symposium on Nuclear and Related Techniques (NURT) are organized jointly, by Instituto Superior de Tecnologias y Ciencias Aplicadas and Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear. Both events gather scientists from several countries with top research work on nuclear physics and its applications. WONP has been carried out since 1994 promoting an ever-exchanging exchange between professionals of various nuclear and applied physics fields, those related to environmental and health care. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

  17. Patho-epidemiological study on Genotype-XIII Newcastle disease virus infection in commercial vaccinated layer farms

    Directory of Open Access Journals (Sweden)

    J. H. Khorajiya

    2015-03-01

    Full Text Available Aim: The present research work was carried out to study the patho-epidemiological aspects of Genotype-XIII Newcastle disease virus (NDV infection in commercial layer in and around Anand, Gujarat. As the outbreaks have reported in vaccinated flocks, it was felt necessary to study the disease with respect to its changing pathogenicity and relevant aspects. Materials and Methods: The study comprised of patho-epidemiology of Newcastle disease (ND by information collected from different layer farms suffering from the disease in relation to incidence pattern and mortality, duration of mortality, susceptible age, and loss due to production performance. Clinical signs were recorded based on observations. During postmortem, gross lesions were also recorded. For histopathological examination visceral organs according to lesions were collected in 10% formalin and processed slide stained by hematoxylin and eosin for microscopic examination. Cultivation of virus was done in embryonated specific pathogen-free (SPF eggs of 9-11 days and isolation of virus was done for haemagglutination (HA and haemagglutination inhibition (HI test and to identify pathotype of virus by intracerebral pathogenicity index (ICPI test to determine the virulence of virus. The Genotype-XIII NDV was confirmed by F gene sequence and whole genome sequence. Results: During the study mortality due to ND was recorded in 13 layer flocks in spite of routine vaccination, which usually contain Genotype-II strain of virus. The mortality was observed as high as above 50% with an average of 21.21%. The susceptible age for disease was found to be 6-14 weeks. The duration of mortality observed was 23 days. The disease resulted in a significant reduction in body weight, feed intake and drop in egg production. Majority of the outbreaks appeared during extremely hot months of April to June. Greenish diarrhoea was frequently seen in birds that survived early in infection. Mortality continued for 2

  18. Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency.

    Science.gov (United States)

    Alioglu, Bulent; Ozsoy, M Hakan; Tapci, Esra; Karamercan, Sirma; Agras, Pinar I; Dallar, Yildiz

    2013-01-01

    In this article, we present a 7-year-old boy with Schoenlein-Henoch purpura (HSP) presented with compartment syndrome and factor XIII deficiency and treated with recombinant factor VIIa and fasciotomy. Treatment decisions for patients with HSP presenting with compartment syndrome should be made on a case-by-case basis. Factor XIII deficiency should be in mind in these patients. The use of recombinant factor VIIa might be effective and well tolerated for treating hemorrhage in patients with HSP and compartment syndrome. Surgical treatment should be preferred in patients with compartment syndrome. However, in patients who have a coagulation defect, the first priority is to correct the clotting deficiency. The use of recombinant factor VIIa is a treatment option for children who develop compartment syndrome due to a coagulation defect.

  19. PREFACE: XIII International Seminar on Physics and Chemistry of Solids (ISPCS)

    Science.gov (United States)

    Berdowski, Janusz

    2007-06-01

    This volume of Journal of Physics: Conference Series contains some of the papers which were presented at the XIII International Seminar on Physics and Chemistry of Solids (ISPCS) in June 2007, in Ustroń, Poland. As the materials from ISPCS are presented in this Journal for the first time it is a good opportunity to give a brief outline of the Seminar's roots, history and goals. The initiator of the Seminars, conceived as annual meetings of the physicists and chemists from Ukraine and Poland, was the late Professor of the Ivan Franko National University in Lviv, Wlodymyr Sawicki. As Professor Sawicki had also lectured for the students of Jan Dlugosz University in Czȩstochowa he had seen both these universities as future organizers of the conference. Coincidentally rectors of Lviv and Czȩstochowa universities, Professor Ivan Vakarchuk and Professor Józef Światek were physicists so this proposition was received very warmly and got strong support from the officials of the universities. From the early beginnings the Seminar also had wide organizational help from the Research and Development Enterprise 'Carat' from Lviv and especially from its president Dr Mykola Vakiv. The Seminars started in 1996—the first meeting took place in Zakopane (Poland) in May 1996 and the second one in September of the same year in Schack (Ukraine). From 1997, ISPCS Seminars have gathered together a group of chemists and physicists interested in condensed matter physics and chemistry, in even years in Ukraine, in odd years in Poland. This circle is growing: at the first Seminar in Zakopane thirty scientists took part, mainly from Lviv and from Czȩstochowa, ISPCS13 gave us the opportunity to meet over eighty people from several universities and research institutions, including delegates from countries other than Poland and Ukraine, with over seventy presentations. The organizers plan that ISPCS conferences should achieve the following two objectives: help in building closer

  20. PREFACE: XIII International Conference on Calorimetry in High Energy Physics (CALOR 2008)

    Science.gov (United States)

    Livan, Michele

    2009-07-01

    The XIII International Conference on Calorimetry in High Energy Physics was held in Pavia, Italy, 26-30 May 2008, picking up the baton from the 2006 Conference in Chicago. The Conference took place in the unique environment of the Theresian Room of the University Library. The attendees were surrounded by over 40 000 books of general interest and culture, and had the opportunity to see precious volumes written by such people as Galileo, Volta and Faraday. The Workshop brought together more than 120 participants, including senior scientists as well as young physicists, confirming the central and ever-growing role of calorimeters in modern particle physics. The development of these detectors, as stressed by Professor Klaus Pretzl in his lectio magistralis, has made it possible to explore new frontiers in physics, and the present scenario is no exception to this rule. With the LHC experiments almost completely installed and ready to take data, the Conference was an ideal chance to review the status of the different projects, whose development has been followed and discussed throughout the entire Calor series, and to show that they are capable of meeting the design specifications. Other highlights were the performance and physics results of calorimeters installed in currently operating experiments. In the session on astrophysics and neutrinos, the contributions confirmed the key role of calorimeters in this sector and demonstrated their growing application even beyond the field of accelerator physics. Considerable time was devoted to the state-of-the-art techniques in the design and operation of the detectors, while the session on simulation addressed the importance of a thorough understanding of the shower development to meet the demanding requirements of present experiments. Finally, on the R&D side, the particle flow and dual read-out concepts confronted the challenges issued by the next generation of experiments. This complex material was reviewed in 83

  1. Excursión por puntos de interés didáctico de la Sierra de Madrid: Geología, Biología e Historia

    OpenAIRE

    Cárdaba, Juan Antonio; Fesharaki, Omid; Presumido, María; Ancón, Marco; Ferrer Mejía, Genaro; Hontecillas, Daniel

    2015-01-01

    Comunicación presentada en el XIII Encuentro en Jóvenes Investigadores en Paleontología (XIII EJIP) - XIII Meeting of Early-Stage Researchers in Paleontology (XIII EJIP): Cercedilla, 15 - 18 de Abril de 2015

  2. Conservación y restauración en la investigación paleontológica en el yacimiento de El Sidrón (Asturias): Estado de la cuestión

    OpenAIRE

    Fernández-Cascón, Beatriz; Rosas, Antonio; Estalrrich, Almudena; García-Tabernero, Antonio; Huguet, Rosa; López-Polín, Lucía; Corchado, Yolanda; Gimeno, Mónica; Rasilla, Marco de la

    2015-01-01

    Comunicación presentada en el XIII Encuentro en Jóvenes Investigadores en Paleontología (XIII EJIP) - XIII Meeting of Early-Stage Researchers in Paleontology (XIII EJIP): Cercedilla, 15 - 18 de Abril de 2015

  3. Estimación de edad de muerte en neandertales mediante histomorfometría

    OpenAIRE

    Bañuelos, Laura; Rosas, Antonio; Ríos, Luis

    2015-01-01

    Comunicación presentada en el XIII Encuentro en Jóvenes Investigadores en Paleontología (XIII EJIP) - XIII Meeting of Early-Stage Researchers in Paleontology (XIII EJIP): Cercedilla, 15 - 18 de Abril de 2015

  4. Stage design

    International Nuclear Information System (INIS)

    Shacter, J.

    1975-01-01

    A method is described of cycling gases through a plurality of diffusion stages comprising the steps of admitting the diffused gases from a first diffusion stage into an axial compressor, simultaneously admitting the undiffused gases from a second diffusion stage into an intermediate pressure zone of said compressor corresponding in pressure to the pressure of said undiffused gases, and then admitting the resulting compressed mixture of diffused and undiffused gases into a third diffusion stage

  5. Stage-dependent toxicity of bisphenol a on Rhinella arenarum (anura, bufonidae) embryos and larvae.

    Science.gov (United States)

    Wolkowicz, Ianina R Hutler; Herkovits, Jorge; Pérez Coll, Cristina S

    2014-02-01

    The acute and chronic toxicity of bisphenol A (BPA) was evaluated on the common South American toad Rhinella arenarum embryos and larvae by means of continuous and pulse exposure treatments. Embryos were treated continuously from early blastula (S.4) up to complete operculum (S.25), during early larval stages and by means of 24 h pulse exposures of BPA in concentrations ranging between 1.25 and 40 mg L(-1) , in order to evaluate the susceptibility to this compound in different developmental stages. For lethal effects, S.25 was the most sensitive and gastrula was the most resistant to BPA. The Teratogenic Index for neurula, the most sensitive embryonic stage for sublethal effects was 4.7. The main morphological alterations during early stages were: delayed or arrested development, reduced body size, persistent yolk plug, microcephaly, axial/tail flexures, edemas, blisters, waving fin, underdeveloped gills, mouth malformations, and cellular dissociation. BPA caused a remarkable narcotic effect from gill circulation stage (S.20) onwards in all the organisms exposed after 3 h of treatment with 10 mg L(-1) BPA. After recovering, the embryos exhibited scarce response to stimuli, erratic or circular swimming, and spasmodic contractions from 5 mg L(-1) onwards. Our results highlight the lethal and sublethal effectsof BPA on R. arenarum embryos and larvae, in the last case both at structural and functional levels. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

  6. Venezuela-MEM/USA-DOE Fossil Energy Report XIII-1, Supporting Technology for Enhanced Oil Recovery, Microbial EOR

    Energy Technology Data Exchange (ETDEWEB)

    Ziritt, Jose Luis

    1999-11-03

    The results from Annex XIII of the Cooperative Agreement between the United States Department of Energy (DOE) and the Ministry of Energy and Mines of the Republic of Venezuela (MEMV) have been documented and published with many researchers involved. Integrate comprehensive research programs in the area of Microbial Enhanced Oil Recovery (MEOR) ranged from feasibility laboratory studies to full-scale multi-well field pilots. The objective, to cooperate in a technical exchange of ideas and information was fully met throughout the life of the Annex. Information has been exchanged between the two countries through published reports and technical meetings between experts in both country's research communities. The meetings occurred every two years in locations coincident with the International MEOR conferences & workshops sponsored by DOE (June 1990, University of Oklahoma, September 1992, Brookhaven, September 1995, National Institute of Petroleum and Energy Research). Reports and publications produced during these years are listed in Appendix B. Several Annex managers have guided the exchange through the years. They included Luis Vierma, Jose Luis Zirritt, representing MEMV and E. B. Nuckols, Edith Allison, and Rhonda Lindsey, representing the U.S. DOE. Funding for this area of research remained steady for a few years but decreased in recent years. Because both countries have reduced research programs in this area, future exchanges on this topic will occur through ANNEX XV. Informal networks established between researchers through the years should continue to function between individuals in the two countries.

  7. Trading stages

    DEFF Research Database (Denmark)

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim

    2012-01-01

    because they are hard to use and interpret, and tools for age and stage structured populations are missing. We present easily interpretable expressions for the sensitivities and elasticities of life expectancy to vital rates in age-stage models, and illustrate their application with two biological......Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  8. Materiales y técnicas constructivas en la Murcia andalusí (siglos X-XIII

    Directory of Open Access Journals (Sweden)

    Navarro Palazón, Julio

    2011-12-01

    Full Text Available The evolution of the materials and building techniques of the andalusian city of Murcia between the 9th and 13th centuries are here studied, mainly based on the new information provided by the numerous archaeological excavations that have been carried out in the city for the last thirty years, related especially to residential architecture. After its accuracy analysis, some differences between the buildings techniques manufactured in the 10th and 11th centuries and those later attributed to 12th and 13th centuries have been identified, being thus highly important to describe them by remarking at the same time those distinguishing features. Problems related to the absolute chronology of these building techniques are also discussed, highlighting the definitive information currently known. With the main aim of analysing how general these remarks are or, on the contrary, if they depend on the regionalization phenomenon characterizing the andalusian recording material, we will compare the information obtained in Murcia with those coming from other andalusian sites, located these far away from the studied area. Finally, we will check if there are differences between the rural and urban environments by comparing the materials and building techniques recorded in two coetaneous sites in Murcia, both sited close to the same river Segura and 40 km distant from each other: the city of Murcia (a large madîna and the deserted settlement of Siyâsa (a hisn.En el presente trabajo estudiamos la evolución de los materiales y técnicas constructivas en la Murcia andalusí, durante un periodo de tiempo que se extiende entre los siglos X y XIII, para lo que nos basaremos especialmente en la rica información extraída de las numerosas excavaciones efectuadas en dicha ciudad, que se refiere sobre todo a arquitectura residencial. Tras su exhaustivo análisis hemos identificado algunas diferencias entre las fábricas de los siglos X y XI y las posteriores de los

  9. Un quirógrafo impugnado. Zamora y la cultura jurídica zamorana a comienzos del siglo XIII

    Directory of Open Access Journals (Sweden)

    Linehan, Peter

    2009-06-01

    Full Text Available Because so soon after it was overtaken by the School of Salamanca, historians have neglected the importance of the Chapter of nearby Zamora in the legal development of early thirtheenth century Spain. In the light of the ambivalent significance of Zamora’s proximity to the kingdom of Portugal in a period of political tension with the papacy, and the role of Zamora’s man at the papal curia, Cardinal Gil Torres, the present study attempts to view that development in terms of its own time, making use of the material evidence in the Vatican and peninsular archives of Zamora’s juristic activity, the level of juristic sophistication revealed by a routine case involving local clergy and laity, and the calculations of the contemporary rulers of León.

    Debido a que muy pronto fue sobrepasada por la Escuela de Salamanca, los historiadores han descuidado la importancia del Capítulo de la cercana Zamora en el progreso jurídico español de los comienzos del siglo XIII. A la luz del ambivalente significado de la proximidad de Zamora al reino de Portugal, en un periodo de tensión política con el papado y del papel desempeñado por el Cardenal zamorano Gil Torres en la curia papal, el presente estudio se propone examinar ese progreso de la actividad jurídica de Zamora durante su tiempo, utilizando para ello los testimonios de los archivos del Vaticano y peninsulares, el nivel de sofisticación jurídica manifestado en un caso rutinario en el que se implicaba un clérigo local y el laicado, así como las astucias de los gobernantes coetáneos de León.

  10. Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

    Science.gov (United States)

    Beckers, Cora M L; Simpson, Kingsley R; Griffin, Kathryn J; Brown, Jane M; Cheah, Lih T; Smith, Kerrie A; Vacher, Jean; Cordell, Paul A; Kearney, Mark T; Grant, Peter J; Pease, Richard J

    2017-08-01

    To establish the cellular source of plasma factor (F)XIII-A. A novel mouse floxed for the F13a1 gene, FXIII-A flox/flox (Flox), was crossed with myeloid- and platelet-cre-expressing mice, and cellular FXIII-A mRNA expression and plasma and platelet FXIII-A levels were measured. The platelet factor 4-cre.Flox cross abolished platelet FXIII-A and reduced plasma FXIII-A to 23±3% ( P cre on plasma FXIII-A was exerted outside of the megakaryocyte lineage because plasma FXIII-A was not reduced in the Mpl -/- mouse, despite marked thrombocytopenia. In support of this, platelet factor 4-cre depleted FXIII-A mRNA in brain, aorta, and heart of floxed mice, where FXIII-A pos cells were identified as macrophages as they costained with CD163. In the integrin αM-cre.Flox and the double copy lysozyme 2-cre.cre.Flox crosses, plasma FXIII-A was reduced to, respectively, 75±5% ( P =0.003) and 30±7% ( P <0.001), with no change in FXIII-A content per platelet, further consistent with a macrophage origin of plasma FXIII-A. The change in plasma FXIII-A levels across the various mouse genotypes mirrored the change in FXIII-A mRNA expression in aorta. Bone marrow transplantation of FXIII-A +/+ bone marrow into FXIII-A -/- mice both restored plasma FXIII-A to normal levels and replaced aortic and cardiac FXIII-A mRNA, while its transplantation into FXIII-A +/+ mice did not increase plasma FXIII-A levels, suggesting that a limited population of niches exists that support FXIII-A-releasing cells. This work suggests that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor. © 2017 The Authors.

  11. Castillos, poder feudal y reorganización espacial en la Transierra madrileña (siglos XII-XIII

    Directory of Open Access Journals (Sweden)

    Iñaki Martín Viso

    2000-01-01

    Full Text Available Algunos castillos de la Transierra madrileña en los siglos xii y xiii son herederos de los husün musulmanes, pero se convierten en esa época en centros de poder señorial sobre unas débiles comunidades. No obstante, sólo su transformación en concejos permitirá la supervivencia de algunos de ellos, aunque se observa también un desplazamiento del habitat hacia el llano, resultado de la formación de un nuevo sistema productivo basado en la agricultura cerealfstica y la propiedad feudal, por lo que el papel de los castillos es limitado. En las zonas serranas su relevancia es aún menor y nunca estructuraron el paisaje, labor que ejercieran los sexmos de la Tierra de Segovia.Some castles of the Madrid's Transierra in the xii"" and xiif" centuries are inheritors of the muslim husün, but they viere converted during this age in centres of a lordship power which was imposed to the weak communities. However, only some of them could survive through their conversión In town counciis (concejos, although there is also an habitat's displacement to the plain, that is the result of the new producing system based on the grain agrículture and the feudal property, so the role of the castles was reduced. In the mountain áreas the landscape was never structured by castles, but by the rural distrícts (sexmos ofthe Segovia's Land.

  12. Esclavos musulmanes en los hospitales de cautivos de la Orden Militar de Santiago (siglos XII y XIII

    Directory of Open Access Journals (Sweden)

    Echevarría Arsuaga, Ana

    2007-12-01

    Full Text Available Military Orders had slave manpower in their lands since their foundation. However, the hospitals for ransoming captives owned by the Order of Santiago are the best example of how slavery worked in the kingdom of Leon-Castile during the twelfth and thirteenth centuries. These houses had enough room to provide lodging for captives while ransoms were being negotiated. They also helped to redistribute those Muslims who, lacking this possibility, became slaves of the order itself, or were sold in the slave markets of the kingdom. The scarce records kept in the Archivo Histórico Nacional, section Órdenes Militares, referring to slaves, help to understand the development of traffic, work and manumission of these people.

    Las órdenes militares dispusieron desde su fundación de mano de obra esclava en sus tierras, pero la institución que mejor sirve para estudiar la esclavitud en los siglos XII y XIII en los reinos de León y Castilla son los hospitales para la redención de cautivos de la Orden de Santiago. Estas instituciones disponían de espacio para alojar a los cautivos mientras se negociaban rescates con los poderes islámicos, y atendían a la redistribución de aquellos musulmanes que, por no haber sido redimidos, pasaban a ser esclavos de la propia orden o a ser vendidos en los mercados de los reinos cristianos. Los escasos documentos de la sección de Órdenes Militares del Archivo Histórico Nacional dedicados a esclavos ayudan a comprender el funcionamiento del tráfico, trabajo y liberación de este colectivo.

  13. Scientific session NRNU MEPHI-2010. XIII International Telecommunication Conference of students and young scientists Young people and science. Book of abstracts. In three parts. Part 1

    International Nuclear Information System (INIS)

    2010-01-01

    In the collection of works there are the abstracts of reports included in the program of XIII International Telecommunication Conference of students and young scientists Young people and science which took place in the Internet in November-December, 2009 on the NRNU MEPhI site http://www.molod.mephi.ru/. The topics of the conference cover a wide range of problems: applied physics and energetics, ecology, development of new materials, medical physics, nanotechnologies, automatics and electronics, information-telecommunication systems and others [ru

  14. La nueva mentalidad urbana y la teneduría de libros por partida doble: Génova, Venecia y Florencia, siglos XIII a XVI

    OpenAIRE

    Abel María Cano-Morales; Carlos Mario Restrepo-Pineda; Omar Osvaldo Villa-Monsalve

    2015-01-01

    El artículo presenta unas reflexiones iniciales sobre la Historia de la Contabilidad y el método histórico, en particular las implicaciones de la “Nueva Historia” en la Historia de la Contabilidad, en el entendido de que los hechos tienen sentido solo si se les considera en un contexto: Luca Pacioli y la revolución comercial del siglo XIII, el cambio de mentalidad en la forma de afrontar el mundo en el espacio y el tiempo, el mundo se percibe ahora de una forma cuantificada; para explicar ...

  15. Staging atmospheres

    DEFF Research Database (Denmark)

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr

    2015-01-01

    The article introduces the special issue on staging atmospheres by surveying the philosophical, political and anthropological literature on atmosphere, and explores the relationship between atmosphere, material culture, subjectivity and affect. Atmosphere seems to occupy one of the classic...

  16. Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration

    Directory of Open Access Journals (Sweden)

    Francesco Parmeggiani

    2015-08-01

    Full Text Available Macular degenerations represent leading causes of central blindness or low vision in developed countries. Most of these severe visual disabilities are due to age-related macular degeneration (AMD and pathologic myopia (PM, both of which are frequently complicated by subfoveal choroidal neovascularization (CNV. Photodynamic therapy with verteporfin (PDT-V is still employed for CNV treatment in selected cases or in combined regimen. In Caucasian patients, the common polymorphism G185T of factor XIII-A gene (FXIII-A-G185T; rs5985 has been described as predictor of poor angiographic CNV responsiveness to PDT-V. Nevertheless, the prognostic implications of this pharmacogenetic determinant on long-term visual outcome after a PDT-V regimen have not been evaluated. We retrospectively selected Caucasian patients presenting with treatment-naive CNV and receiving standardized PDT-V protocol for two years. The study population included patients affected by subfoveal CNV secondary to AMD or PM. We assessed the correlations between the polymorphic allele T of FXIII-A-G185T and: (1 total number of photodynamic treatments; and (2 change in visual acuity from baseline to the end of the follow-up period. Considering a total study population of 412 patients with neovascular AMD or PM, the carriers of 185 T-allele of FXIII-A (GT or TT genotype received a higher number of photodynamic treatments than patients without it (GG wild-type genotype (p < 0.01; mean number of PDT-V: 5.51 vs. 3.76, respectively. Moreover, patients with 185 T-allele of FXIII-A had a more marked worsening of visual acuity at 24 months than those with the GG-185 wild genotype (p < 0.01; mean difference in logMAR visual acuity: 0.22 vs. 0.08, respectively. The present findings show that the G185T polymorphism of the FXIII-A gene is associated with significant differences in the long-term therapeutic outcomes of patients treated with standardized PDT-V protocol. The comprehensive appraisal of

  17. Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration.

    Science.gov (United States)

    Parmeggiani, Francesco; Costagliola, Ciro; Semeraro, Francesco; Romano, Mario R; Rinaldi, Michele; Gallenga, Carla Enrica; Serino, Maria Luisa; Incorvaia, Carlo; D'Angelo, Sergio; De Nadai, Katia; Dell'Omo, Roberto; Russo, Andrea; Gemmati, Donato; Perri, Paolo

    2015-08-20

    Macular degenerations represent leading causes of central blindness or low vision in developed countries. Most of these severe visual disabilities are due to age-related macular degeneration (AMD) and pathologic myopia (PM), both of which are frequently complicated by subfoveal choroidal neovascularization (CNV). Photodynamic therapy with verteporfin (PDT-V) is still employed for CNV treatment in selected cases or in combined regimen. In Caucasian patients, the common polymorphism G185T of factor XIII-A gene (FXIII-A-G185T; rs5985) has been described as predictor of poor angiographic CNV responsiveness to PDT-V. Nevertheless, the prognostic implications of this pharmacogenetic determinant on long-term visual outcome after a PDT-V regimen have not been evaluated. We retrospectively selected Caucasian patients presenting with treatment-naive CNV and receiving standardized PDT-V protocol for two years. The study population included patients affected by subfoveal CNV secondary to AMD or PM. We assessed the correlations between the polymorphic allele T of FXIII-A-G185T and: (1) total number of photodynamic treatments; and (2) change in visual acuity from baseline to the end of the follow-up period. Considering a total study population of 412 patients with neovascular AMD or PM, the carriers of 185 T-allele of FXIII-A (GT or TT genotype) received a higher number of photodynamic treatments than patients without it (GG wild-type genotype) (p < 0.01; mean number of PDT-V: 5.51 vs. 3.76, respectively). Moreover, patients with 185 T-allele of FXIII-A had a more marked worsening of visual acuity at 24 months than those with the GG-185 wild genotype (p < 0.01; mean difference in logMAR visual acuity: 0.22 vs. 0.08, respectively). The present findings show that the G185T polymorphism of the FXIII-A gene is associated with significant differences in the long-term therapeutic outcomes of patients treated with standardized PDT-V protocol. The comprehensive appraisal of both anti

  18. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and li......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments...

  19. El museo deslumbrante - XIII

    Directory of Open Access Journals (Sweden)

    Fernando Arbelaéz

    1965-05-01

    Full Text Available Es muy agradable tener en Atenas un amigo como Cayetano. Oigo mi propio idioma, y su música es una especie de anestesia muy suave para mis pensamientos. El mundo me parece grotesco, gesticulante y me produce miedo en algún lugar secreto de la mente. Escribo con una facilidad que me sorprende; pero ya se que esto no es más que el resultado de ese sutil mecanismo que reemplaza las pasiones para que podamos subsistir: el rojo de la lujuria va tomando los dorados colores del orgullo con el repique de la máquina. No creo que haya escrito con tanta fluidez y por tan largo tiempo. Es evidente, el ejercicio de teclear descansa los nervios y la concentración descansa el espíritu, así estemos meditando en nuestras propias miserias.

  20. Chapitre XIII. Lord Kitchener

    OpenAIRE

    Abbas Hilmi II,

    2017-01-01

    Son caractère. Famille. Carrière au Foreign-Office. Carrière administrative en Egypte. Ministre plénipotentiaire. Mariage. Mort. Action bénéfique en Egypte. Les Égyptiens ne l’ont pas apprécié à sa juste valeur. C’est tout au début de sa carrière politique que Sir Eldon Gorst est arrivé en Égypte où il avait été nommé Sous-Secrétaire d’État au Ministère des Finances. Tout le monde s’étonna qu’un homme aussi jeune ait pu être désigné pour occuper une fonction aussi importante. Sa formation de ...

  1. Fronteras exteriores e interiores en la creación de un reino medieval: Valencia en el siglo XIII

    Directory of Open Access Journals (Sweden)

    Enric GUINOT RODRÍGUEZ

    2009-12-01

    Full Text Available RESUMEN: La génesis de las fronteras de los reinos cristianos medievales en España tiene mucho que ver con los procesos de guerra y conquista frente a al-Andalus. Éste es el caso del reino de Valencia, creado por el rey Jaime I en el año 1240 a partir de varios territorios musulmanes. Sus fronteras exteriores se crearon a partir de los límites entre cristianos y musulmanes en aquel momento y también por los pactos políticos con la corona de Castilla repartiéndose el territorio de al-Andalus. Pero estas fronteras no fueron definitivas y aún durante más de un siglo los conflictos entre la corona de Aragón y la de Castilla llevaron a cambios importantes en ellas.Por otro lado, la conquista feudal de Valencia implicó su reparto en señoríos y villas reales con la consiguiente necesidad de crear fronteras interiores para delimitarlos. Muchas veces estos límites se basaron en los existentes en época islámica, si bien fue usual que la sociedad feudal los interpretase según criterios propios y locales. Además, al estar ya en pleno siglo XIII, la organización de municipios se convirtió en la unidad básica de organización territorial, si bien existió una jerarquía entre las villas y los pueblos de su término.ABSTRACT: The origin of the borders of the medieval Christian kingdoms in Spain has much to do with the processes military and conquers over al-Andalus. This is the case of the kingdom of Valencia, created by King Jaime I in 1240 from several Muslim territories. Their outer borders were created from the boundaries between Christians and Muslims at that moment, but also by the political pacts with the crown of Castile distributing the territory of al-Andalus. But these borders were not definitive and still for more than a century the conflicts between Aragon and Castile took to important changes in them.On the other hand, the feudal conquest of Valencia implied its distribution between seigneuries and royal cities with the

  2. Las capillas y capellanías reales castellano-leonesas en la Baja Edad Media (siglos XIII-XV: algunas precisiones institucionales

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    Nogales Rincón, David

    2005-12-01

    Full Text Available The study of royal chapels and royal chaplaincies is focus on the analysis of the relationships between de Palace Chapel and the cathedral/monastic royal chapels from a institucional, ideologic and functional criterions, on making a systematization of them and on presenting some general notes about their characteristics, ideal patterns and development in the late Middle Ages in Castille (13th-15th centuries.

    El estudio de las capillas y capellanías reales se centra en el análisis de las relaciones entre la Capilla Palacio y las capillas reales catedralicias/monásticas desde un punto de vista institucional, ideológico y funcional, en llevar a cabo una sistematización de éstas y ofrecer algunas notas generales sobre sus características, modelos ideales y evolución en la Castilla bajomedieval (siglos XIII-XV.

  3. Averroes en la revolución intelectual del siglo XIII: bases para una reinterpretación de la Modernidad

    OpenAIRE

    Herráiz Oliva, Pilar

    2016-01-01

    El objetivo de esta tesis es mostrar cómo, en el siglo XIII, en la facultad de artes de la Universidad de París, el averroísmo, o el aristotelismo radical, emergió como movimiento filosófico que defendía la autonomía de la razón, de la filosofía y de la ciencia. Otro de los objetivos de esta tesis es mostrar que la secularización y la especialización de las distintas ciencias, tal y como las concebimos hoy, tienen su origen en la nueva forma de hacer filosofía que surge de las exigencias meto...

  4. Quando rey perdemos nunq[u]a bien nos fallamos. La muerte del rey en la Castilla del siglo XIII

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    Pérez Monzón, Olga

    2007-12-01

    Full Text Available This article deals with the funeral spaces of the Castilian kings during the 13th century, and the iconography of their tombs as the reflection of a political ideational system tending toward the sanctification of the monarchy. This elevation of royalty provoked an open conflict with certain members of the nobility and the royal family, as well as a political and artistic response.

    El presente artículo trata sobre los ámbitos fúnebres de los reyes castellanos durante el siglo XIII y la particularidad iconográfica de sus monumentos tumulares como reflejo de un ideario político tendente a la sacralización de la monarquía. El encumbramiento de la realeza provocó un abierto conflicto con determinados miembros de la realeza y la familia real y una respuesta política y artística.

  5. ¿Reina la reina? Mujeres en la cúspide del poder en los reinos hispánicos de la edad media (siglos VI-XIII

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    María Jesús Fuente

    2003-01-01

    Full Text Available Las cualidades de una mujer elegida como esposa de un rey quedan bien definidas en los códigos de leyes medievales; sin embargo, sus funciones no están explicitadas. Definir el papel de las reinas en los reinos fiispánicos de la Edad Media es el objetivo de este artículo. Tomando como base fuentes primarias y secundarias, se estudia la actuación de las reinas desde el siglo VI al XIII, en concreto algunas figuras representativas o de las que hiay información en una documentación escasa y poco explícita. Se sigue su evolución en tres grandes etapas: las reinas visigodas (siglos VI-VII, las reinas o condesas de los núcleos de resistencia del Norte peninsular (siglos Vlll-X, y las reinas de los siglos XI al XIII en los ámbitos de Aragón-Cataluña y Castilla-León.Although medieval legal codes spell out the qualifications of tfie king wife to be, thiey do not mention tier role. To define tier role is tfie goal of tfiis article, wfíich look at tfie queen in tfie híspanle kingdoms of the Middie Ages. Based on primary and secondary sources, it discusses the role of the queens from the Vlth to the Xlllth centuries. The study looks first at the visigoth queens (Vlth-Vllth centuries, then at the queens and countesses of the small kingdoms of Northern Spain (Vlllth-Xth centuries, and finally at the queens of Aragón-Cataluña and Castile- Leon during the Xlth, Xllth and Xlllth centuries.

  6. Embryonic Developmental Stages of African Giant Catfish Heterobranchus longifilis (Valenciennes, 1840) (Teleostei, Clariidae)

    Science.gov (United States)

    Wilfred-Ekprikpo, P. C.

    2016-02-01

    One of the major challenges confronting the globe is the issue of food insecurity. This problem results from inadequate protein intake by humans especially those people from the third world countries. In order to arrest this ugly situation, there is the need to increase protein production by intensifying aquaculture. In sub-saharan Africa, particularly Nigeria, the major aquaculture species is African mud catfish (Clarias gariepinus) and its production has increase protein output but the protein deficit is still wide. Thus, necessitating the need to develop other aquaculture species endemic to the region. One of these species is Heterobranchus and there successful breeding depending on a good understanding of their biology. The embryonic developmental stages of Heterobranchus longifilis in freshwater tanks were determined. The first cleavage cell division occurred 30 minutes after fertilization of eggs while, the morula stage was observed within 2 hours. The blastula stage occurred between 2 and 8 hours, while the gastrula stage occurred between 12 and 18 hours. Thereafter, neurulation period, and embryonic body formation appeared. The optical vesicle and auditory vesicle formed. Finally muscular contraction, tail formation, heartbeat and hatching occurred. The embryonic developmental stage of H. longifilis started immediately the oocyte (egg) was fertilized and terminated when the embryo hatched from the chorion membranous wall. The young larva emerged from the embryonic membrane at 24.46 hrs with vigorous lashing of the caudal region against the chorion membrane. The average weight and length of the yolk larvae were 0.005g and 0.43 cm respectively. The percentage fertilization and hatchability rates were 82.50 and 65.10% respectively. The experiment revealed that Heterobranchus longifilis could be a good aquaculture species.

  7. GRAB THE GARB: THE INFLUENCES OF TRANSLATION TECHNIQUES IN THE LUDOLOGICAL ASPECTS OF VIDEO GAME TRANSLATION (A Case Study of Square Enix’s Lightning Returns: Final Fantasy XIII

    Directory of Open Access Journals (Sweden)

    SF. Luthfie Arguby Purnomo

    2015-09-01

    Full Text Available Penelitian deskriptif kualitatif ini bertujuan untuk mengungkapkan tipe teknik penerjemahan dalam terjemahan garb, kostum dengan kekuatan khusus dalam Lightning Returns: Final Fantasy XIII, dan pengaruhnya terhadap aspek ludologi, mekanika game yang dalam hal ini merujuk kepada kekuatan khusus (ability yang terkandung dalam garb yang diterjemahkan. Temuan penelitian menunjukkan bahwa hanya terdapat dua teknik penerjemahan yang digunakan dalam penerjemahan 93 nama garb yaitu pure borrowing (44 data dan adaptasi (49 data. Dari 49 data adaptasi yang diperoleh, 40 adaptasi menunjukkan bahwa adaptasinya mampu mempertahankan aspek ludologi keikuatan khusus garb yang diperoleh dari pemahaman awal mengenai nama garb dan bentuk fisiknya. Sementara itu 9 adaptasi yang lain memberikan pengaruh negatif terhadap aspek ludologi karena putusnya keterkaitan antara makna nama garb dan ability yang dimilikinya. Temuan ini menandakan bahwa dalam penerjemahan video game, pesan yang dialihkan tidak hanya pesan lingustik tetapi juga pesan mekanis atau ludologis yang terdapat dalam elemen video game. Kata kunci: ludologi, teknik penerjemahan, garbs, Lightning Returns: Final Fantasy XIII

  8. Moneda oficial i diversitat monetària a Catalunya a la primera meitat del segle XIII: El cas de Vic

    Directory of Open Access Journals (Sweden)

    Ginebra i Molins, Rafel

    1996-12-01

    Full Text Available While medieval coinage is normally studied from a numismatic point of view or as a fiscal instrument or element of income for the public authorities responsible of the coinage, this study, considering the references to different currencies in notarial documentation and especially in the first volume of the Cúria Fumada archive of Vic (3,308 documents covering the period September 1230 to December 1233, analyses the monetary types wich were really in use in the interior of Catalonia during the first half of de XIII century, documenting up to nine simultaneous different currencies. This study analyses the different currencies, their relative importance, their ambit of use and their specialisation and equivalencies. New information is also provided regarding a particular subject as is the episcopal stamping of coins in Vic during the first half of the XIII century.[fr] Si normalement on étudie la monnaie médiévale dès le point de vue numismatique ou comme un instrument ou un élément de fiscalité ou de rente des pouvoirs publics qui la frappent, cette étude, qui part des références à monnaie dans la documentation notariale et très particulièrement dans le premier volume des Arxives de la Cúria Fumada de Vic (3.308 documents de la période de septembre 1230 à décembre 1233, analyse la monnaie qui circule reélement dans la Catalogne intérieure pendant la première moitié du XlIIe. siècle, en documentant jusqu'à neuf numéraires simultanés différents. L'étude analyse les différentes monnaies, leur importance relative, leurs enceintes d'usage, leur spécialisation et leurs équivalences. L'étude apporte aussi de nouvelles données à l'aspect ponctuel des frappes de monnaie episcopale de Vie à la première moitié du XIIe. siècle.

  9. O moio-medida e o moio dos preços em Portugal nos séculos Xl a XIII

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    Seabra Lopes, Luis

    2005-06-01

    Full Text Available In this paper, the value of the modius (modio, moyo, moio in Portugal in the 11th to the 13th centuries is studied. By this time, the modius was both a measure of capacity and a unit used in the specification of prices. The author concludes that, while the modius-measure had a capacity not under the horse charge (210 to 220 litters in the legal systems used in Portugal from the end of the 11th century onwards, some smaller modii continued to be used in rural areas far away from the main urban centers. These smaller modii had a capacity around 50 to 75 litters. With respect to the modius-price, the information gathered by the author indicates a value between 25 and 55 litters of cereal. Therefore, it becomes clear that the modius-price was not equivalent to the standard modius-measure, although it could be equivalent to the smaller modii still in use in rural areas. The gathered evidence also suggests that, from the 10th to the 13th centuries, independently of inflation, the modius-price remained approximately equivalent to the currency unit known as solidus

    Neste artigo, estuda-se o valor do moio (modius, modio, moyo em Portugal nos séculos XI a XIII. Nesta época, o moio era simultaneamente uma medida de capacidade e uma unidade usada na especificação dos preços. Este estudo permite concluir que, enquanto o moio-medida tinha, nos sistemas legais em vigor em Portugal a partir de finais do século XI, uma capacidade não inferior à carga de cavalo (210 a 220 litros, alguns moios mais pequenos continuaram a ser utilizados em áreas rurais afastadas dos principais centros urbanos. Estes moios mais pequenos tinham capacidades em torno de 50 a 75 litros. Relativamente ao moi-preço, a informação reunida indica um valor entre 25 e 55 litros de cereal, Torna-se, assim, evidente, que o moio-preço não era equivalente ao moio-medida comum, podendo, no entanto, ser equivalente aos moios menores que ainda sobreviviam nas áreas rurais. A

  10. Understanding cancer staging

    Science.gov (United States)

    ... detailed information about the cancer stage. TNM Staging System The most common system for staging cancer in the form of solid tumor is the TNM system. Most providers and cancer centers use it to stage ...

  11. In vitro stimulation of stage-specific deoxyribonucleic acid synthesis in rat seminiferous tubule segments by interleukin-1 α

    International Nuclear Information System (INIS)

    Parvinen, M.; Soeder, O.M.; Mali, P.; Froeysa, B.R.; Ritzen, E.M.

    1991-01-01

    Levels of rat testicular interleukin-1-like factor (tIL-1) have been shown to correlate with DNA synthetic activity during the cycle of the rat seminiferous epithelium, suggesting its role as a spermatogonial or meiotic growth factor. To explore this further, a new in vitro model system was developed. Rat seminiferous tubule segments from stages I, V, VIIa, and VIII-IX of the cycle were isolated by transillumination-assisted microdissection, cultured in chemically defined serum-free medium supplemented with human recombinant IL-1 α, and labeled with [3H]thymidine. During incubation, spontaneous progression of spermatogenesis was noted. Inactive stage VIIa tubule segments differentiated to stage VIII and initiated DNA synthesis, and concomitantly started to secrete IL-1-like factor. DNA synthesis of stages VIII-IX ceased through differentiation of spermatocytes to leptotene-zygotene (stages XII-XIII of the cycle). IL-1 α stimulated DNA synthesis significantly in spermatogonia of stage I. Meiotic DNA synthesis at stage VIIa was stimulated (48 h/34 C) and maintained at stages VIII-IX (48 h/34 C). IL-1 α seems to act as a regulator of spermatogenic DNA synthesis in both mitotic and meiotic phases. It has mainly stimulating and maintaining effects, but it may also be inhibitory under certain conditions

  12. Eça de Queirós versus Papa Leão XIII: questões alimentares (Eça de Queirós versus Pope Leo XIII: food issues - DOI: 10.5752/P.2175-5841.2012v10n28p1363

    Directory of Open Access Journals (Sweden)

    Antonio Augusto Nery

    2012-12-01

    Full Text Available O artigo “Encíclica Poética” foi publicado por Eça de Queirós (1845 -1900 na Revista Moderna em 20 de outubro de 1897 e coligido postumamente no volume Notas Contemporâneas, em 1909. Eça versa sobre uma epístola que o Papa Leão XIII (1810-1903 escreveu e dedicou a certo Fabricius Rufus, seu conterrâneo romano, com o intuito de sugerir o que seria uma nobre alimentação cristã. O pontífice, grande conhecedor do latim e adepto de passatempos literários, dava indicações “politicamente corretas” de como colocar a mesa, as bebidas e as suntuosas guloseimas que se iriam servir, constituindo, nas palavras de Eça, uma “encíclica poética sobre a alimentação cristã”. Eça tece comentários sobre a carta papal buscando confrontar os ensinamentos do Papa com as atitudes de vários santos e santas da Igreja Católica que teriam vivido diversas abdicações, dificuldades e renúncias, especialmente com relação à alimentação, para alcançar a santidade. Nas contraposições explicitadas nesse artigo, escrito por Eça apenas alguns anos antes de sua morte, podemos constatar o mesmo discurso crítico e sarcástico voltado à Instituição religiosa e aos seus representantes que permeou obras anteriores como O crime do padre Amaro (1871 e A relíquia (1887. Palavras-chave: Eça de Queirós. “Encíclica Poética”. Notas Contemporâneas. Papa Leão XIII.   Abstract: The text “Encíclica Poética” was published by Eça de Queirós (1845 -1900 on Revista Moderna magazine on October, 20th in 1897 and later gathered in the volume Notas Contemporâneas, in 1909. Eça writes about an epistle the Pope Leão XIII (1810-1903 wrote and dedicated to a certain Fabricius Rufus, his Roman countryman, with the aim to suggest what a Christian noble nourishing would be like. The pontiff, great Latin expert and fond of literary pastimes, used to give “politically correct” instructions on how to set the table, the beverages and the

  13. Il fenomeno abachistico a supporto dei cambiamenti socio-economici: Arezzo tra il XIII ed il XVI secolo = The role of the abacus tradition for the economic and social development of the society: evidence from Tuscany (Italy between XIII and XVI century

    Directory of Open Access Journals (Sweden)

    Maria Pia Maraghini

    2011-12-01

    Full Text Available Este artículo indaga sobre los orígenes de la contabilidad con el objetivo de analizar el comportamiento económico. En particular, se examinan los primeros lugares específica-mente dispuestos y organizados para la enseñanza del conocimiento contable así como los medios de estudio para su transmisión: las escuelas y los libros de ábaco. Ampliamente extendidos en Italia entre los siglos XIII y XVI tenían la finalidad de transmitir, por un lado, el conocimiento generalmente difundido como matemática práctica y, por otro, las técnicas para realizar operaciones aritméticas y las reglas prácticas para la resolución de problemas comerciales y financieros.El objetivo de esta investigación es profundizar en el estudio de las escuelas y de los libros de ábaco evidenciando el papel desempeñado en el origen de la contabilidad y en el desarrollo económico y social en la época medieval y los primeros siglos del Renacimiento.Con este fin, el estudio se basa en algunas evidencias sobre la evolución de los estudios y las escuelas de ábaco en Arezzo (Toscana, Italia entre los siglos XIII y XVI. Combinando evidencias similares con el análisis teórico el estudio revela la contribución de la tradición del ábaco en el mejor desarrollo de la vida pública en época medieval y renacentista. La constatación de esta contribución ha sido la base del creciente interés mostrado hacia la cultura del ábaco por las autoridades locales de la época.This paper focuses on the “origins” of the book-keeping art which aims to record economic behaviour. In particular, this research investigates the early specific “places” arranged and organized to teach the accounting knowledge and the primitive “means” of study with which it could be handed over: the abacus schools and books. They prevalently spread in Italy between XIII and XVI century with the aim of transferring the knowledge generally defined as “practical maths”, such as the

  14. La Cura Monialium en los monasterios de monjas dominicas de la Castilla del siglo XIII: un análisis comparativo entre dos comunidades

    Directory of Open Access Journals (Sweden)

    Ríos de la Llave, Rita

    2008-06-01

    Full Text Available The resistance of the friars to take over the nuns hindered the inclusion of the female communities in the Dominican Order, which were under cloister and needed spiritual assistance and help for their businesses. This article deals with this problem in Castile during the 13th century. The situation in the foundations of Madrid and San Esteban de Gormaz –later moved to Caleruega– is analysed. But, although the general situation affected them, they did not always fit in the model established by the Papacy and accepted by the authorities of the Order so that the conflict could end.La inserción de comunidades femeninas en la Orden dominicana se vio dificultada por la resistencia de los frailes a hacerse cargo de las monjas, que estaban sometidas a clausura, y necesitaban asistencia espiritual y ayuda en los asuntos temporales. El presente artículo aborda este problema en la Castilla del siglo XIII a través del análisis de la situación en las instituciones fundadas en Madrid y San Esteban de Gormaz –luego trasladada a Caleruega–, que se vieron afectadas por la problemática general, si bien no siempre se ajustaron de forma estricta al modelo establecido por el Papado y aceptado por las autoridades de la Orden para solucionar el conflicto.

  15. Cruzada, herejía e inquisición en las tierras de la Corona de Aragón (siglos XII-XIII

    Directory of Open Access Journals (Sweden)

    Smith, Damian

    2013-06-01

    Full Text Available This study explores three interconnected subjects concerning the general theme of heterodoxy in the Thirteenth Century: the Albigensian Crusade; the increase of heresy in the lands of the Crown of Aragón, and the development of the Inquisition. Firstly, we ask if the decisions taken by James I were the necessary consequence of the defeat of the battle of Muret in order to avoid a direct conflict with the papacy and France. Second, we examine where heresy as present and absent in the lands of the Crown. Third, we suggest reasons why the inquisition took a distinctive form in the lands of the Crown.Este estudio explora tres asuntos conectados con el tema general de la heterodoxia en el siglo XIII: la Cruzada contra los Albigenses, el aumento de la herejía en las tierras de la Corona de Aragón y el desarrollo de la Inquisición. Nos preguntamos, primero, si las decisiones tomadas por Jaime I fueron la consecuencia necesaria de la derrota en la batalla de Muret para evitar un conflicto directo con el Papado y Francia. Segundo, examinamos dónde estuvo presente y dónde ausente la herejía en las tierras de la Corona de Aragón. Tercero, sugerimos las razones por las qué la Inquisición adoptó una forma distintiva en las tierras catalano-aragonesas.

  16. Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.

    Science.gov (United States)

    Deicke, Christin; Chakrakodi, Bhavya; Pils, Marina C; Dickneite, Gerhard; Johansson, Linda; Medina, Eva; Loof, Torsten G

    2016-11-01

    Coagulation is a mechanism for wound healing after injury. Several recent studies delineate an additional role of the intrinsic pathway of coagulation, also known as the contact system, in the early innate immune response against bacterial infections. In this study, we investigated the role of factor XIII (FXIII), which is activated upon coagulation induction, during Streptococcus pyogenes-mediated skin and soft tissue infections. FXIII has previously been shown to be responsible for the immobilization of bacteria within a fibrin network which may prevent systemic bacterial dissemination. In order to investigate if the FXIII-mediated entrapment of S. pyogenes also influences the disease outcome we used a murine S. pyogenes M1 skin and soft tissue infection model. Here, we demonstrate that a lack of FXIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination. Moreover, FXIII-deficient mice show an impaired survival when compared with wildtype animals. Additionally, local reconstitution of FXIII-deficient mice with a human FXIII-concentrate (Fibrogammin ® P) could reduce the systemic complications, suggesting a protective role for FXIII during early S. pyogenes skin infection. FXIII therefore might be a possible therapeutically application to support the early innate immune response during skin infections caused by S. pyogenes. Copyright © 2016 Elsevier GmbH. All rights reserved.

  17. Energy levels, lifetimes, and transition rates for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI

    Science.gov (United States)

    Wang, K.; Yang, X.; Chen, Z. B.; Si, R.; Chen, C. Y.; Yan, J.; Zhao, X. H.; Dang, W.

    2017-09-01

    Energy levels, wavelengths, lifetimes, oscillator strengths, and electric dipole (E1), magnetic dipole (M1), electric quadrupole (E2), magnetic quadrupole (M2) transition rates among the 46 fine structure levels belonging to the ([ Ar ] 3d10) 4s2 4p4, ([ Ar ] 3d10) 4s2 4p3 4 d, and ([ Ar ] 3d10) 4 s 4p5 configurations for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI are reported. These data are determined in the multi-configuration Dirac-Fock (MCDF) approach, in which relativistic effects, main electron correlations within the n = 7 complex, Breit interaction (BI), and quantum electrodynamic (QED) corrections are included. The many-body perturbation theory (MBPT) method is also employed as an independent calculation to confirm the present accuracy, taking W XLI as an example. Comparisons and analysis are made between the present results and available experimental and theoretical ones, and good agreements are obtained. These accurate data are expected to be useful in nuclear fusion research and astrophysical applications.

  18. Embryonic development and larval stages of Steindachneridion parahybae (Siluriformes: Pimelodidae: implications for the conservation and rearing of this endangered Neotropical species

    Directory of Open Access Journals (Sweden)

    Renato M. Honji

    Full Text Available Steindachneridion parahybae is a freshwater catfish endemic to the Paraíba do Sul River and is classified as an endangered Neotropical species. An increasing number of conservation biologists are incorporating morphological and physiological research data to help conservation managers in rescue these endangered species. This study investigated the embryonic and larval development of S. parahybae in captivity, with emphasis in major events during the ontogeny of S. parahybae. Broodstocks were artificially induced to reproduce, and the extrusion occurred 200-255 degree-hours after hormonal induction at 24°C. Larval ontogeny was evaluated every 10 minutes under microscopic/stereomicroscopic using fresh eggs samples. The main embryogenic development stages were identified: zygote, cleavage, including the morula, blastula, gastrula phase, organogenesis, and hatching. The extruded oocytes showed an average diameter of 1.10 ± 0.10 mm, and after fertilization and hydration of eggs, the average diameter of eggs increased to about 1.90 ± 0.60 mm, characterized by a large perivitelline space that persisted up to embryo development, the double chorion, and the poles (animal and vegetative. Cell division started about 2 minutes after fertilization (AF, resulting in 2, 4, 8 (4 x 2 arrangement of cells, 16 (4 x 4, 32 (4 x 8 and 64 (2 x 4 x 8 cells. Furthermore, the blastula and gastrula stages followed after these cells divisions. The closed blastopore occurred at 11 h 20 min AF; following the development, the organogenetic stages were identified and subdivided respectively in: early segmentation phase and late segmentation phase. In the early segmentation phase, there was the establishment of the embryonic axis, and it was possible to distinguish between the cephalic and caudal regions; somites, and the optic vesicles developed about 20 h AF. Total hatching occurred at 54 h AF, and the larvae average length was 4.30 ± 0.70 mm. Gradual yolk sac reduction

  19. Prostate cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000397.htm Prostate cancer staging To use the sharing features on this ... trials you may be able to join How Prostate Cancer Staging is Done Initial staging is based on ...

  20. Universidade, cidade e liberdade no Século XIII: uma perspectiva de análise na história da educação

    Directory of Open Access Journals (Sweden)

    Terezinha Oliveira

    2013-07-01

    Full Text Available Nosso objetivo é refletir sobre a relevância da História e da História da Educação na construção do sentimento e do ideal de liberdade. Urdiremos os fios que construirão o texto recuperando documentos medievais do século XIII. Trata-se de duas Cartas sobre a Universidade de Paris e uma referente à libertação de uma Comuna. Retomaremos, também, textos de Tomás de Aquino, pois em consonância com as questões de seu tempo debateu sobre a importância do desenvolvimento intelectivo para a vida em comunidade. A história evidencia que a liberdade não se conquista somente por meio das instituições, pois ainda que o homem viva sob a égide de instituições democráticas, só terá, de fato, liberdade quando detiver o conhecimento necessário para nortear suas ações, em vista de seus interesses particulares e em consonância com os interesses públicos. Por fim, observamos que nosso caminhar teórico segue a linha da história social, uma vez que nela encontramos a possibilidade de aliar a história, a memória e o filosofar para construir um conhecimento no qual o todo do ser humano - o material e o mental - é conservado.

  1. La nueva mentalidad urbana y la teneduría de libros por partida doble: Génova, Venecia y Florencia, siglos XIII a XVI

    Directory of Open Access Journals (Sweden)

    Abel María Cano-Morales

    2015-01-01

    Full Text Available El artículo presenta unas reflexiones iniciales sobre la Historia de la Contabilidad y el método histórico, en particular las implicaciones de la “Nueva Historia” en la Historia de la Contabilidad, en el entendido de que los hechos tienen sentido solo si se les considera en un contexto: Luca Pacioli y la revolución comercial del siglo XIII, el cambio de mentalidad en la forma de afrontar el mundo en el espacio y el tiempo, el mundo se percibe ahora de una forma cuantificada; para explicar el cambio de mentalidad en el Renacimiento se utiliza el concepto de Tiempo en dos momentos en la historia de Occidente: la Antigüedad y el Renacimiento; en este último periodo, el pensamiento moderno se va formando de acuerdo con unas condiciones sociales, a una práctica social e histórica, producto de la vida en las ciudades y en especial del comercio; el comercio sufre una revolución, se pasa de un comercio ambulante a un comercio “sedentario”, en materia de cuentas esta revolución significa un cambio de filosofía contable, al introducirse la partida doble en las ciudades del norte de Italia, pues ahora se integran e interrelacionan todos los elementos que constituyen el patrimonio, registrando sus cambios de estructura y los desarrollos de cada una de las variables del sistema. Producto de esta transformación en la forma de hacer las cuentas son las empresas de los Fugger, pero, especialmente, las familias florentinas: los Peruzzi, los Bardi, los Médicis.

  2. Computing the free energy of molecular solids by the Einstein molecule approach: ices XIII and XIV, hard-dumbbells and a patchy model of proteins.

    Science.gov (United States)

    Noya, E G; Conde, M M; Vega, C

    2008-09-14

    The recently proposed Einstein molecule approach is extended to compute the free energy of molecular solids. This method is a variant of the Einstein crystal method of Frenkel and Ladd [J. Chem. Phys. 81, 3188 (1984)]. In order to show its applicability, we have computed the free energy of a hard-dumbbell solid, of two recently discovered solid phases of water, namely, ice XIII and ice XIV, where the interactions between water molecules are described by the rigid nonpolarizable TIP4P/2005 model potential, and of several solid phases that are thermodynamically stable for an anisotropic patchy model with octahedral symmetry which mimics proteins. Our calculations show that both the Einstein crystal method and the Einstein molecule approach yield the same results within statistical uncertainty. In addition, we have studied in detail some subtle issues concerning the calculation of the free energy of molecular solids. First, for solids with noncubic symmetry, we have studied the effect of the shape of the simulation box on the free energy. Our results show that the equilibrium shape of the simulation box must be used to compute the free energy in order to avoid the appearance of artificial stress in the system that will result in an increase in the free energy. In complex solids, such as the solid phases of water, another difficulty is related to the choice of the reference structure. As in some cases there is no obvious orientation of the molecules; it is not clear how to generate the reference structure. Our results will show that, as long as the structure is not too far from the equilibrium structure, the calculated free energy is invariant to the reference structure used in the free energy calculations. Finally, the strong size dependence of the free energy of solids is also studied.

  3. Valor y sentido del conocimiento en las órdenes mendicantes del Siglo XIII - doi: 10.4025/actascieduc.v32i2.9775

    Directory of Open Access Journals (Sweden)

    Gerald Cresta

    2010-12-01

    Full Text Available El Siglo XIII se expresa por medio de un concepto propio de la Universidad en que todo el saber debía estar orientado a la sapientia sacrae paginae, que fue expresada por la teología. Esta cuestión representaba sin duda un ideal de la Iglesia, pero asimismo un desafío especulativo para los pensadores de entonces. Con la complejidad epistemológica heredada del siglo XII y la inserción de las órdenes mendicantes en la labor académica, principalmente dominicos y franciscanos, esta fase de la historia de las ideas asistía a un antagonismo fundamental: el naturalismo de la herencia clásica -junto con el aporte del pensamiento árabe- y el humanismo cristiano se disputan la explicación del fin último del hombre. El valor y el sentido del conocimiento dependería en gran medida de la respuesta dada a esta diversidad de orientaciones. Y si bien es un hecho clave la influencia de los grandes autores antiguos, aristotelismo y neoplatonismo no son prerrogativa de una y otra orden. En los escritos de Santo Tomás está presente el neoplatonismo y es asimismo significativa la orientación empírica de la escuela franciscana en Inglaterra. Unos y otros, sin embargo, concordarían en una unidad del saber que podríamos interpretar bajo el signo de los trascendentales del ser. 

  4. A antropofagia trovadoresca - O trovadorismo galego-português nos séculos XIII e XIV e sua assimilação de influências externas e internas à Península Ibérica

    OpenAIRE

    José D’Assunção Barros

    2016-01-01

    Entre os séculos XIII e XIV – no contexto do desenvolvimento do trovadorismo medieval – os reinos ibéricos de Portugal e Castela conheceram um movimento trovadoresco particularmente rico na assimilação das contribuições trovadorescas externas e internas à Península Ibérica. A “antropofagia cultural” dos trovadores galegoportugueses, tal como a ela nos estaremos referindo para evocar um conceito de Oswald de Andrade, adaptou-se particularmente aos projetos políticos dos reis de Portugal e Cast...

  5. XIII International science and technology conference High-tech chemical technologies-2010 with elements of Scientific school for young people Innovations in chemistry: achievements and prospects. Summaries of reports

    International Nuclear Information System (INIS)

    2010-01-01

    Materials of the XIII International science and technology conference High-tech chemical technologies-2010 with elements of Scientific school for young people Innovations in chemistry: achievements and prospects (29 June-2 July 2010, Ivanovo) are presented. During the conference the following areas: theoretical aspects of chemical technology; technology of deep oil refining and the production of organic substances; technology of drugs and biologically active substances; technology of inorganic materials, polymers and composites based on them - the technological principles and methods of synthesis, modification, and processing; environmental and economic problems of chemical technologies and their solutions are considered [ru

  6. Between Stage and Screen

    NARCIS (Netherlands)

    Tornqvist, Egil

    1996-01-01

    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Tornqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio

  7. La expansión del posesivo pospuesto a la luz de documentación navarra (y aragonesa del siglo XIII

    Directory of Open Access Journals (Sweden)

    Ángeles Romero Cambrón

    2016-06-01

    Full Text Available En los primitivos documentos romances el posesivo sólo aparece antepuesto al sustantivo (“(el nuestro padre”. La posposición (“padre nuestro” se empieza a registrar en el siglo XIII en aragonés y en dialecto navarro. Considerando principalmente la documentación de esta segunda variedad, el presente trabajo tiene como objetivo determinar el modo en que el posesivo adquirió la capacidad de aparecer pospuesto. Este cambio se vio impulsado por factores de naturaleza estructural. Uno de ellos es la existencia de la construcción posesiva con de y pronombre personal (“por raçón de mí”; otro, la concurrencia del posesivo en coordinación, bien con el sintagma preposicional (“nin subdito vuestro nin de la eglesia”, bien con otro posesivo (“l’amor nuestra e vuestra”. El posesivo se pospondría adoptando la posición propia del sintagma preposicional. Asimismo, habría influido en la imposición del cambio la tendencia a aligerar la posición prenominal cuando concurrían en ella más de un adyacente. In the first Romance texts, possessives only occur in prenominal position (e.g. (el nuestro padre. The earliest records of postposition (e.g. padre nuestro date back to the 13th century in Aragonese and in Navarrese dialect. This paper reports largely on documentation involving Navarrese in order to determine in what way the postpositive placement of the possessive became normal. The influence of three grammar structures has been found to trigger possessive postposition. The first structure is a possessive construction consisting of the preposition de followed by a personal pronoun (e.g. campo de nos. The second structure includes a possessive in coordination either with a prepositional phrase (nin subdito vuestro nin de la eglesia or with another possessive (l’amor nuestra e vuestra. In this case, the possessive occurs after the noun in the natural place of a prepositional phrase. Finally, possessive postposition became a

  8. Hospitalarios y obispos en Castilla durante los siglos XII y XIII = Hospitallers and Bishops in Castile During the Twelfth and Thirteenth Centuries

    Directory of Open Access Journals (Sweden)

    Carlos Barquero Goñi

    2017-05-01

    Full Text Available La Orden de San Juan disfrutó de periodos de buena sintonía con el episcopado en Castilla y León. Sin embargo, era irremediable que surgieran conflictos jurisdiccionales entre ambos poderes. En Castilla y León aparecen desde el último cuarto del siglo XII. A diferencia de otras órdenes militares, los hospitalarios castellano-leoneses tienden a llevar estos pleitos con poca violencia y buscan rápidamente un acuerdo con el obispo correspondiente. La solución fue la común y usual en todos los litigios que enfrentaron a las órdenes militares con el episcopado durante los siglos XII y XIII. La Orden de San Juan y el obispo correspondiente se dividieron los derechos eclesiásticos de las iglesias hospitalarias. El reparto variaba en cada diócesis en función de la correlación de fuerzas existente. Esta clase de avenencias comienzan a hacerse en Castilla y León a partir de finales del siglo XII. Por lo general, cada sede episcopal llegaba a un solo acuerdo con la Orden. Con todo, hubo algunas como Zamora, Astorga o Toledo, con las que el Hospital realizó varios acuerdos. Las concordias de este tipo representaron el más decisivo mecanismo de acomodación de la Orden de San Juan en las estructuras de la Iglesia castellano-leonesa.There were many periods in which good relations prevailed between the Order of Saint John and the bishops of Castile. However, it was inevitable that jurisdictional conflicts would eventually arise between the two powers. In Castile, they appear since the last quarter of the twelfth century. Unlike other military orders, the Castilian Hospitallers usually carried out this litigation with little violence and quickly sought an agreement with the concerned bishop. They often arrived at a standard solution to the disputes among the military orders and the bishops in the twelfth and thirteenth centuries. The ecclesiastical rights of Hospitaller churches were divided between the Order of Saint John and a specific bishop

  9. Breast cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000911.htm Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  10. Seven Stages of Alzheimer's

    Science.gov (United States)

    ... Dementias . Learn more: Daily Care and Behaviors Severe Alzheimer's disease (late-stage) Get support Late-stage care decisions can be some of the hardest families face. Connect with other caregivers who have been through the process on our ...

  11. Stages of Adolescence

    Science.gov (United States)

    ... Español Text Size Email Print Share Stages of Adolescence Page Content Article Body Adolescence, these years from puberty to adulthood, may be roughly divided into three stages: early adolescence, generally ages eleven to fourteen; middle adolescence, ages ...

  12. Beyond Erikson's Eight Stages.

    Science.gov (United States)

    Whitney, Ruth

    1979-01-01

    Erik Erikson has described eight stages of the healthy personality. This essay offers a revised version of the eight stages. Although most individuals develop through the eight stages, each is personally unique because patterns of fluctuation between safety and growth differ from one individual to another. (Author)

  13. Cervical Cancer Stage IIIA

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IIIA Add to My Pictures View /Download : ... 1275x1275 View Download Large: 2550x2550 View Download Title: Cervical Cancer Stage IIIA Description: Stage IIIA cervical cancer; drawing ...

  14. Cervical Cancer Stage IVA

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IVA Add to My Pictures View /Download : ... 1575x1200 View Download Large: 3150x2400 View Download Title: Cervical Cancer Stage IVA Description: Stage IVA cervical cancer; drawing ...

  15. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IVB Add to My Pictures View /Download : ... 1200x1305 View Download Large: 2400x2610 View Download Title: Cervical Cancer Stage IVB Description: Stage IVB cervical cancer; drawing ...

  16. Cervical Cancer Stage IIIB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IIIB Add to My Pictures View /Download : ... 1425x1326 View Download Large: 2850x2651 View Download Title: Cervical Cancer Stage IIIB Description: Stage IIIB cervical cancer; drawing ...

  17. Cervical Cancer Stage IB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IB Add to My Pictures View /Download : ... 1613x1200 View Download Large: 3225x2400 View Download Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...

  18. Cervical Cancer Stage IA

    Science.gov (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : Small: 720x576 ... Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical cancer; drawing ...

  19. Isotope hydrology investigations in Latin America 1994. Investigations on hydrology and hydrogeology in Latin America on water resources and groundwater pollution. Results achieved during the implementation of the project RLA/8/014 - ARCAL XIII: Application of isotope techniques in hydrology

    International Nuclear Information System (INIS)

    1995-10-01

    This IAEA Technical Document contains 17 articles about the results achieved during the implementation of the project RLA/8/014, ARCAL XIII, aimed at the application of isotope techniques in hydrology in the Caribbean and Latin America. Also included is the list of 19 participants in the project. Refs, figs and tabs

  20. Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

    Science.gov (United States)

    2014-12-29

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer

  1. Multiple stage railgun

    International Nuclear Information System (INIS)

    Aaland, K.; Hawke, R.S.; Scudder, J.K.

    1982-01-01

    A multiple stage magnetic railgun accelerator for accelerating a projectile by movement of a plasma arc along the rails. The railgun is divided into a plurality of successive rail stages which are sequentially energized by separate energy sources as the projectile moves through the bore of the railgun. Propagation of energy from an energized rail stage back towards the breech end of the railgun can be prevented by connection of the energy sources to the rails through isolation diodes. Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails into electrically isolated rail sections. In such case means are used to extinguish the arc at the end of each energized stage and a fuse or laser device is used to initiate a new plasma arc in the next energized rail stage

  2. Turbine stage model

    International Nuclear Information System (INIS)

    Kazantsev, A.A.

    2009-01-01

    A model of turbine stage for calculations of NPP turbine department dynamics in real time was developed. The simulation results were compared with manufacturer calculations for NPP low-speed and fast turbines. The comparison results have shown that the model is valid for real time simulation of all modes of turbines operation. The model allows calculating turbine stage parameters with 1% accuracy. It was shown that the developed turbine stage model meets the accuracy requirements if the data of turbine blades setting angles for all turbine stages are available [ru

  3. Symposium Symmetries in Science XIII

    CERN Document Server

    Gruber, Bruno J; Yoshinaga, Naotaka; Symmetries in Science XI

    2005-01-01

    This book is a collection of reviews and essays about the recent developments in the area of Symmetries and applications of Group Theory. Contributions have been written mostly at the graduate level but some are accessible to advanced undergraduates. The book is of interest to a wide audience and covers a broad range of topics with a strong degree of thematical unity. The book is part of a Series of books on Symmetries in Science and may be compared to the published Proceedings of the Colloquia on Group Theoretical Methods in Physics. Here, however, prevails a distinguished character for presenting extended reviews on present applications to Science, not restricted to Theoretical Physics.

  4. Radiation Effects on Polymers - XIII

    DEFF Research Database (Denmark)

    El-Awady, N. I.; Ghanem, N. A.; Bo, P.

    1979-01-01

    Using computerized programs, the water flux and salt rejection properties in reverse osmosis of cellulose acetate-g-acrylamide membranes are determined. Comparisons are made with ungrafted commercial cellulose acetate membranes, using 0.1 and 1.0 M sodium chloride, sodium sulphate and ammonium...

  5. La renta señorial de la Orden de San Juan en Castilla durante los siglos XII y XIII = Rents from the Lordships of the Order of Saint John in Castile during the Twelfth and Thirteenth Centuries

    Directory of Open Access Journals (Sweden)

    Carlos Barquero Goñi

    2016-06-01

    Full Text Available La Orden de San Juan obtuvo muchos recursos de sus dominios en Castilla durante los siglos XII y XIII. Sus fuentes de renta eran las contribuciones habituales en el régimen señorial durante la Edad Media. Sin embargo, el principal ingreso era una parte del diezmo eclesiástico que la Orden percibía en sus señoríos.The Order of Saint John collected significant resources from their domains in Castile during the twelfth and thirteenth centuries. Their sources of income were the usual contributions of the manorial system during the Middle Ages. Nevertheless, their main source of income was a fraction of the ecclesiastical tithe that the order perceived in their lordships.

  6. Aristotélisme et christologie au XIII-ème siècle. Le problème du corps du Christ dans les derniers écrits de saint Thomas d’Aquin

    Directory of Open Access Journals (Sweden)

    Cristian Moisuc

    2009-06-01

    Full Text Available The purpose of this paper is to analyze the problem of the relationship between Aristotelianism and Christology in the XIII-th century, as it appears through the famous problem of the body of Christ dead. This problem, which divided the Latin theologians and which St. Thomas Aquinas will try to find a final answer turns out to be very suggestive for the question of the relationship between the Greek philosophy and the so-called Thomistic synthesis. The article offers an analysis of the latest works of St.Thomas (Quodlibet III and IV and the 50-th question of Part III of the Summa Theologiae in which the theologian tries to reconcile the requirements of hylomorphism with Christian dogma. The article offers also a critical interpretation of these solutions, as well as some remarks on the possibility and limits of dialogue between the Greek philosophy and the foolishness of the cross.

  7. Ciudades y poder político en al-Andalus. Una hipótesis sobre el origen de las revueltas urbanas en Murcia en el siglo XIII

    Directory of Open Access Journals (Sweden)

    Frey Sánchez, Antonio Vicente

    2014-12-01

    Full Text Available Throughout the 13th century a succession of urban revolts took place in al-Andalus, which caused the withdrawal of the Almohad Empire and the establishment of the third taifas, initially led by Muhammad b. Yūsuf b. Hūd al-Mutawakkil. The inability of this emir to hold together this newly-built state, and the continuous insurrections inside and utside of Murcia have led historians to investigate the nature of political power during this period. This article examines each one of these proposals and, on the basis of an analysis of some socio-economic aspects relating to Murcia (being a representative city of al-Andalus and capital of the hūdí movement during the first half of the thirteenth century, proposes a hypothesis on the nature of its power.Durante el siglo XIII se produjo una serie de revueltas urbanas en al-Andalus que ocasionó la retirada del Imperio almohade y la formación de las terceras taifas, inicialmente encabezadas por Muḥammad b. Yūsuf b. Hūd al-Mutawakkil. La incapacidad de este emir para mantener unido el estado que había creado y las continuas insurrecciones fuera y dentro de Murcia ha llevado a historiadores y filólogos a indagar sobre la naturaleza del poder político en este periodo. Este artículo estudia cada una de estas interpretaciones y, a partir del análisis de algunos aspectos socio-económicos de Murcia, ciudad representativa en al-Andalus y capital del movimiento hūdí durante la primera mitad del siglo XIII, presenta una propuesta sobre la naturaleza de su poder.

  8. Staging of cutaneous melanoma

    NARCIS (Netherlands)

    P. Mohr (P.); A.M.M. Eggermont (Alexander); A. Hauschild (Axel); A. Buzaid (A.)

    2009-01-01

    textabstractThe American Joint Committee on Cancer (AJCC) staging of cutaneous melanoma is a continuously evolving system. The identification of increasingly more accurate prognostic factors has led to major changes in melanoma staging over the years, and the current system described in this review

  9. Book Review Zimbabwean mbira music on an international stage ...

    African Journals Online (AJOL)

    London: Ashgate, SOAS Musicology series. ISBN: 978-0-7546-5799-6. eBook: ISBN 978-0-7546-8688-0. xiii, 116 pp, notation, photographs (black & white), CD. Includes Chartwell Dutiro & Spirit Talk Mbira (2002).Taanerimwe: Chartwell Dutiro with Spirit Talk Mbira live at Gateway. SOASIS 03. 10 tracks, total duration 61:50 ...

  10. Cryopreservation of green fluorescent protein (GFP)-labeled primordial germ cells with GFP fused to the 3' untranslated region of the nanos gene by vitrification of Japanese eel (Anguilla japonica) somite stage embryos.

    Science.gov (United States)

    Kawakami, Y; Ishihara, M; Saito, T; Fujimoto, T; Adachi, S; Arai, K; Yamaha, E

    2012-12-01

    Primordial germ cells (PGC) are the only cell type in developing embryos with the potential to transmit genetic information to the next generation. In this study, PGC of Japanese eel (Anguilla japonica) were visualized by injection of mRNA synthesized from a construct carrying the green fluorescent protein (GFP) gene fused to the 3' untranslated region of the Japanese eel nanos gene. We investigated the feasibility of cryopreserving Japanese eel PGC by vitrification of dechorionated whole somite stage embryos. The GFP-labeled PGC were rapidly cooled using liquid nitrogen after exposure to a pretreatment solution containing 1.5 M cryoprotectant (methanol, dimethyl sulfoxide, and glycerol for 10 min and ethylene glycol for 10, 20, and 30 min) and a vitrification solution containing 3 M cryoprotectant and 0.5 M sucrose for 1, 5, and 10 min. Ethylene glycerol is an effective cryoprotectant for embryonic cells and shows no evidence of ice formation after thawing. Vitrified and thawed PGC were transplanted into blastula stage embryos from zebrafish (Danio rerio). The GFP-labeled PGC migrated toward the host gonadal ridge, suggesting maintenance of their normal migration motility. These techniques may assist in achieving inter- and intraspecies germ-line chimers using donor Japanese eel PGC.

  11. Staging for vulvar cancer.

    Science.gov (United States)

    Hacker, Neville F; Barlow, Ellen L

    2015-08-01

    Vulvar cancer has been staged by the International Federation of Gynaecology and Obstetrics (FIGO) since 1969, and the original staging system was based on clinical findings only. This system provided a very good spread of prognostic groupings. Because vulvar cancer is virtually always treated surgically, the status of the lymph nodes is the most important prognostic factor and this can only be determined with certainty by histological examination of resected lymph nodes, FIGO introduced a surgical staging system in 1988. This was modified in 1994 to include a category of microinvasive vulvar cancer (stage IA), because such patients have virtually no risk of lymph node metastases. This system did not give a reasonably even spread of prognostic groupings. In addition, patients with stage III disease were shown to be a heterogeneous group prognostically, and the number of positive nodes and the morphology of those nodes were not taken into account. A new surgical staging system for vulvar cancer was introduced by FIGO in 2009. Initial retrospective analyses have suggested that this new staging system has overcome the major deficiencies in the 1994 system. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  12. Staging for vaginal cancer.

    Science.gov (United States)

    Rajaram, Shalini; Maheshwari, Amita; Srivastava, Astha

    2015-08-01

    Vaginal cancer is a rare cancer comprising about 3% of all gynecologic cancers. Primary vaginal cancer should be carefully assigned as spread from cervix, vulva, and other metastatic tumors to vagina can occur. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women. Squamous cell carcinoma is still the most common histopathologic type followed by adenocarcinoma. With decreasing use of diethylstilbestrol in pregnancy, non-diethylstilbestrol-associated cancers are described. The Federation Internationale de Gynecologie et d'Obstetrique (FIGO) staging of vaginal cancer (2009) follows the same rules as cervical cancer; it is clinically staged and allows the use of routine investigative modalities for staging. Although FIGO encourages the use of advanced imaging modalities, such as computed tomography, magnetic resonance imaging (MRI), and positron emission tomography (PET), to guide therapy, the imaging findings may not be used to change or reassign the stage. TNM staging is the pathologic staging system proposed by the American Joint Committee on Cancer, and information available from examination of the resected specimen, including pelvic and inguinal lymph nodes, may be used for staging. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Staged bilateral carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Engell, Hans Christian

    1986-01-01

    In a series of 56 staged bilateral carotid endarterectomies, new neurologic symptoms developed in 5% and 20% following the first and second procedure, respectively. All complications were transient or minor. The incidence of postendarterectomy hypertension was significantly higher following...... the second procedure, when operations were staged less than 3 weeks apart. A correlation between these hypertensive episodes and the occurrence of new neurologic symptoms could not be shown. However, as this correlation has been proved in several other reports, bilateral carotid endarterectomy is advised...... to be staged at least 3 weeks apart. In addition, a conservative attitude towards contralateral asymptomatic lesions is proposed....

  14. Staging of lung cancer.

    Science.gov (United States)

    de Groot, Patricia M; Carter, Brett W; Betancourt Cuellar, Sonia L; Erasmus, Jeremy J

    2015-06-01

    Primary lung cancer is the leading cause of cancer mortality in the world. Thorough clinical staging of patients with lung cancer is important, because therapeutic options and management are to a considerable degree dependent on stage at presentation. Radiologic imaging is an essential component of clinical staging, including chest radiography in some cases, computed tomography, MRI, and PET. Multiplanar imaging modalities allow assessment of features that are important for surgical, oncologic, and radiation therapy planning, including size of the primary tumor, location and relationship to normal anatomic structures in the thorax, and existence of nodal and/or metastatic disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Staging Mobilities / Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2015-01-01

    In recent years, urban research has taken a ‘mobilities turn’. There has been a developing realisation that mobilities do not ‘just happen.’ Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and lived...... asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities? The theoretical framing in the Staging mobilities book is applied to four in-depth cases in the accompanying volume Designing mobilities.This book explore how places, sites...

  16. Stages of Colon Cancer

    Science.gov (United States)

    ... types of surgery : Local excision or simple polypectomy . Resection and anastomosis . This is done when the tumor is too ... stage I colon cancer usually includes the following: Resection and anastomosis . Use our clinical trial search to find NCI- ...

  17. Stages of Labor

    Science.gov (United States)

    ... Moms Need Blog News & Media News Videos Mission stories Ambassadors Spotlights Tools & Resources Frequently asked media questions ... can be born. This stage can last as short as 20 minutes or as long as several ...

  18. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  19. Stages of Esophageal Cancer

    Science.gov (United States)

    ... the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds , ... stage of the cancer being treated. External and internal radiation therapy are used to treat esophageal cancer. A plastic ...

  20. Stages of Anal Cancer

    Science.gov (United States)

    ... the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds , ... stage of the cancer being treated. External and internal radiation therapy are used to treat anal cancer. Chemotherapy Chemotherapy ...

  1. Stages of Penile Cancer

    Science.gov (United States)

    ... the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds , ... stage of the cancer being treated. External and internal radiation therapy are used to treat penile cancer. Chemotherapy Chemotherapy ...

  2. Staging interrail mobilities

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.

    2016-01-01

    This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous...

  3. Stages of ores formation

    International Nuclear Information System (INIS)

    Khasanov, A.Kh.

    1988-01-01

    Deposit formation (especially endogenous) is the complicated, multi-stage and long process. Establishment of deposit formation succession, age-specific correlations of minerals and aggregates have a high importance at solving genetic questions. Studying of minerals correlations and mineral aggregates, succession of their crystallization and other observations let restore the history of deposit formation, pick up in it different on duration and physical and chemical conditions stages

  4. Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

    Science.gov (United States)

    2017-05-03

    Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

  5. Resumen de tesis. El Mišle he-‘araḇ (Los dichos de los árabes) y la tradición sapiencial hebrea (Península Ibérica y Provenza, s. XII y XIII)

    OpenAIRE

    Torollo Sánchez, David

    2014-01-01

    [ES]La obra Mišle he-`arab [Los dichos de los árabes] es una obra escrita en hebreo entre los siglos XII y XIII, dividida en cincuenta capítulos en prosa, con poemas intercalados y de contenido ético sapiencial. De ella se conservan diez manuscritos datados entre los siglos XIII y XVII, cinco de los cuales están completos. Fue además editada por fascículos, capítulo a capítulo, en diversos números no consecutivos de la revista ha Lebanon, mientras era publicada en París entre 1865 y 1869. La ...

  6. Caracterización arqueométrica de pigmentos y soportes procedentes de pinturas murales góticas (S. XIII-XV

    Directory of Open Access Journals (Sweden)

    Kriznar, A.

    2007-04-01

    mortar as support were used in these Gothic wall paintings. Moreover, this feature, besides of cinnabar application, allows to establish the 1400-1410 wall paintings in the artistic Italian current named Trecento. The second procedure to paint is a typical of North Europe: one or two layer of mortar with a fine layer of lime. This is used to improve the strenght of lime as an aglutinant in the mortar. With this study, it is concluded that the Italian and North-European artistic currents met in Slovenian territory, which is appraisable as much stilistic (Art History as scientific (Chemical and Physical analysis point of views. This kind of investigation allows to know better the Central European Art and the Slovenian Art in the Adriatic zone, as well as the general map of European Art in the Middle Age.

    El presente trabajo forma parte de una investigación más amplia sobre pinturas murales góticas (S. XIII-XV. En concreto, se han estudiado las que se encuentran en el interior de varias iglesias de Eslovenia y que no habían sido estudiadas, hasta la fecha, por medio de técnicas instrumentales de análisis de materiales. Una de ellas está situada en la ciudad de Crngrob (Eslovenia y se ha seleccionado como objeto de este estudio (Iglesia de la Anunciación de María. El estudio científico de las muestras en el ICMSE se basó, principalmente, en la preparación de una serie de secciones estratigráficas a partir de los fragmentos pequeños de las mismas para analizar las diferentes capas de mortero soporte y de la propia pintura. Se examinaron dichas preparaciones por varias técnicas, como son fotografía digital, microscopías óptica y electrónica (MEB, espectroscopía IR (reflexión y EDX. Una información adicional sobre pigmentos y morteros se obtuvo mediante IR (transmisión, preparando pastillas con KBr, además de DRX. Las muestras estudiadas pueden clasificarse en dos grupos que, a su vez, permiten apreciar dos formas de pintura mural. La primera es t

  7. Staging of extrahepatic cholangiocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Eun; Choi, Jin-Young [Yonsei University College of Medicine, Department of Diagnostic Radiology, Research Institute of Radiological Science, Seoul (Korea); Kim, Myeong-Jin [Yonsei University College of Medicine, Department of Diagnostic Radiology, Research Institute of Radiological Science, Seoul (Korea); Yonsei University College of Medicine, Institute of Gastroenterology, Yonsei (Korea); Yonsei University Health System, Department of Diagnostic Radiology, Seoul (Korea); Park, Young Nyun [Yonsei University College of Medicine, Institute of Gastroenterology, Yonsei (Korea); Yonsei University College of Medicine, Department of Pathology, Yonsei (Korea); Lee, Yoon-Hee [Yonsei University College of Medicine, Department of Pathology, Yonsei (Korea)

    2008-10-15

    Preoperative staging of extrahepatic cholangiocarcinoma is important in determining the best treatment plan. Several classification systems have been suggested to determine the operability and extent of surgery. Longitudinal tumor extent is especially important in extrahepatic cholangiocarcinoma because operative methods differ depending on the tumor extent. The Bismuth-Corlette classification system provides useful information when planning for surgery. However, this classification system is not adequate for selecting surgical candidates. Anatomic variation of the bile duct and gross morphology of the tumor must be considered simultaneously. Lateral spread of the tumor can be evaluated based on the TNM staging provided by American Joint Committee on Cancer (AJCC). However, there is a potential for ambiguity in the distinction of T1 and T2 cancer from one another. In addition, T stage does not necessarily mean invasiveness. Blumgart T staging is helpful for the assessment of resectability with the consideration of nodal status and distant metastasis as suggested by the AJCC cancer staging system. Computed tomography (CT) and magnetic resonance imaging (MRI) are the primary tools used in the assessment of longitudinal and lateral spread of a tumor when determining respectability. Diagnostic laparoscopy and positron emission tomography (PET) may play additional roles in this regard. (orig.)

  8. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs......, and something quite different is undergoing. This paper intends to discuss three examples of performances in which the composer’s appearance on stage was an important part of the piece, - both when it came to the role as a performer and as an individual person – as representer and presenter. The paper intends...... to rise the following questions: What happens to the status of the author, when he suddenly (re-)appears on stage? How is this appearance to be understood in both a contemporary and historical context: Is it the musical virtuous appearing again, are we witnessing musical works turning...

  9. Staging Collaborative Innovation Processes

    DEFF Research Database (Denmark)

    Pedersen, Signe; Clausen, Christian

    Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation...... and public private innovation partnerships. Based on a case study of a collaborative design process in a large electronics company the paper points to the key importance of staging and navigation of collaborative innovation process. Staging and navigation is presented as a combined activity: 1) to translate...

  10. Are stage IV vestibular schwannomas preoperatively different from other stages?

    Science.gov (United States)

    Tringali, Stéphane; Dubreuil, Christian; Zaouche, Sandra; Ferber-Viart, Chantal

    2008-01-01

    The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs). In this prospective study, we included 734 patients who have VS and candidates for operation. Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging. PREOPERATIVE CLINICAL EVALUATION: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder. Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG). Continuous variables were compared between Stage IV and other stages using analysis of variance. Qualitative variables expressed as a percentage of presence were compared between Stage IV and other stages using percentage comparison. Quantitative Parameters. Patients with Stage IV VS were significantly younger as compared with patients with other stages. Stage IV hearing loss was greater compared with other stages at 250 and 500 Hz but smaller at 2,000 and 8,000 Hz. We found no difference in the loss of PTA between Stage IV and the other stages. Speech discriminancy score was smaller in Stage IV. The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage. Auditory brainstem response patterns showed no difference in Wave III latency between Stage IV VS and other stages, whereas Wave V latency and V-I interval were higher in Stage IV. Both ABR threshold and VNG caloric deficit were higher in Stage IV VS compared with other stages. Qualitative Parameters. The percentage of patients with Stage IV was lower than that with Stages II and III. The percentage of men and women was similar in all stages. The occurrence of hearing loss was similar in all stages, whereas that of tinnitus was lower in Stage IV compared with Stages I and II. In

  11. End-stage kidney disease

    Science.gov (United States)

    ... medlineplus.gov/ency/article/000500.htm End-stage kidney disease To use the sharing features on this page, please enable JavaScript. End-stage kidney disease (ESKD) is the last stage of long-term ( ...

  12. Stage theta pinch experiments

    International Nuclear Information System (INIS)

    Linford, R.K.; Downing, J.N.; Gribble, R.F.; Jacobson, A.R.; Platts, D.A.; Thomas, K.S.

    1975-01-01

    The Staged Theta Pinch program is designed to study the technological and physics problems associated with producing fat plasmas and separating the implosion heating from the adiabatic compression. Several methods of implosion heating are discussed. Circuit diagrams and theoretical magnetic field behavior are described for the STP and resonant heating experiments. (MOW)

  13. "Stage 40" Handbook.

    Science.gov (United States)

    Mill River Union High School, North Clarendon, VT.

    The policies, purposes, and guidelines of "Stage 40," an educational repertory company for students, are presented in this paper, which also explains how the company functions. The paper discusses the company's history, the relationship between the company and academics, and the responsibilities of a company member. Letters by the board…

  14. World Stage Design

    Index Scriptorium Estoniae

    2005-01-01

    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  15. Linac project - actual stage

    International Nuclear Information System (INIS)

    Carlin Filho, N.

    1990-01-01

    The actual development stage of Pelletron accelerator to study heavy ion reactions, nuclear structures and applied nuclear physics is presented. The construction of acceleration systems able to provide beams of several mass and energies up to 20 MeV/A, is discussed, describing acceleration structures and implemented systems. (M.C.K.)

  16. stage/page/play

    DEFF Research Database (Denmark)

    context. Contributors: Per Brask, Dario Fo, Jette Barnholdt Hansen, Pil Hansen, Sven Åke Heed, Ulla Kallenbach, Sofie Kluge, Annelis Kuhlmann, Kela Kvam, Anna Lawaetz, Bent Flemming Nielsen, Franco Perrelli, Magnus Tessing Schneider, Antonio Scuderi. stage/page/play is published as a festschrift...

  17. Staging Collaborative Innovation Processes

    DEFF Research Database (Denmark)

    Pedersen, Signe; Clausen, Christian

    Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation...... and public private innovation partnerships. Based on a case study of a collaborative design process in a large electronics company the paper points to the key importance of staging and navigation of collaborative innovation process. Staging and navigation is presented as a combined activity: 1) to translate...... the diverse matters of concern into a coherent product or service concept, and 2) in the same process move these diverse holders of the matters of concern into a translated actor network which carry or support the concept....

  18. Staging Sociotechnical Spaces

    DEFF Research Database (Denmark)

    Clausen, Christian; Yoshinaka, Yutaka

    2007-01-01

    The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and political...... process theory may contribute to a reflexive understanding of design as the staging of socio-technical relations and processes cutting across boundaries of diverse organisational, political and knowledge domains. This idea is pursued through the notion of ‘socio-technical spaces’. Socio-technical space...... of product development. The concept of socio-technical spaces is further illustrated through actual examples from industry dealing with early conceptualisation in product development and the role played by management concepts in the configuration of spaces....

  19. Calibration of Nanopositioning Stages

    Directory of Open Access Journals (Sweden)

    Ning Tan

    2015-12-01

    Full Text Available Accuracy is one of the most important criteria for the performance evaluation of micro- and nanorobots or systems. Nanopositioning stages are used to achieve the high positioning resolution and accuracy for a wide and growing scope of applications. However, their positioning accuracy and repeatability are not well known and difficult to guarantee, which induces many drawbacks for many applications. For example, in the mechanical characterisation of biological samples, it is difficult to perform several cycles in a repeatable way so as not to induce negative influences on the study. It also prevents one from controlling accurately a tool with respect to a sample without adding additional sensors for closed loop control. This paper aims at quantifying the positioning repeatability and accuracy based on the ISO 9283:1998 standard, and analyzing factors influencing positioning accuracy onto a case study of 1-DoF (Degree-of-Freedom nanopositioning stage. The influence of thermal drift is notably quantified. Performances improvement of the nanopositioning stage are then investigated through robot calibration (i.e., open-loop approach. Two models (static and adaptive models are proposed to compensate for both geometric errors and thermal drift. Validation experiments are conducted over a long period (several days showing that the accuracy of the stage is improved from typical micrometer range to 400 nm using the static model and even down to 100 nm using the adaptive model. In addition, we extend the 1-DoF calibration to multi-DoF with a case study of a 2-DoF nanopositioning robot. Results demonstrate that the model efficiently improved the 2D accuracy from 1400 nm to 200 nm.

  20. A antropofagia trovadoresca - O trovadorismo galego-português nos séculos XIII e XIV e sua assimilação de influências externas e internas à Península Ibérica

    Directory of Open Access Journals (Sweden)

    José D’Assunção Barros

    2016-01-01

    Full Text Available Entre os séculos XIII e XIV – no contexto do desenvolvimento do trovadorismo medieval – os reinos ibéricos de Portugal e Castela conheceram um movimento trovadoresco particularmente rico na assimilação das contribuições trovadorescas externas e internas à Península Ibérica. A “antropofagia cultural” dos trovadores galegoportugueses, tal como a ela nos estaremos referindo para evocar um conceito de Oswald de Andrade, adaptou-se particularmente aos projetos políticos dos reis de Portugal e Castela que àquela altura encaminhavam um projeto de centralização monárquica. O presente artigo busca desenvolver uma síntese dos aspectos envolvidos neste fenômeno de assimilação cultural e recriação de uma poesia trovadoresca bastante original. Palavras chaves: trovadores medievais, trovadores galego-portugueses; antropofagia cultural.

  1. A ANTROPOFAGIA TROVADORESCA - O TROVADORISMO GALEGO-PORTUGUÊS NOS SÉCULOS XIII E XIV E SUA ASSIMILAÇÃO DE INFLUÊNCIAS EXTERNAS E INTERNAS À PENÍNSULA IBÉRICA

    Directory of Open Access Journals (Sweden)

    José D’Assunção Barros

    2016-01-01

    Full Text Available Entre os séculos XIII e XIV – no contexto do desenvolvimento do trovadorismo medieval – os reinos ibéricos de Portugal e Castela conheceram um movimento trovadoresco particularmente rico na assimilação das contribuições trovadorescas externas e internas à Península Ibérica. A “antropofagia cultural” dos trovadores galegoportugueses, tal como a ela nos estaremos referindo para evocar um conceito de Oswald de Andrade, adaptou-se particularmente aos projetos políticos dos reis de Portugal e Castela que àquela altura encaminhavam um projeto de centralização monárquica. O presente artigo busca desenvolver uma síntese dos aspectos envolvidos neste fenômeno de assimilação cultural e recriação de uma poesia trovadoresca bastante original. Palavras chaves: trovadores medievais, trovadores galego-portugueses; antropofagia cultural.

  2. As parroquias do Porriño, Cans e Atios na documentación do mosteiro cisterciense de Santa María de Melón. Séculos XII e XIII

    Directory of Open Access Journals (Sweden)

    Gradín Fernández, Isis

    2011-12-01

    Full Text Available After the introduction and criteria of transcription, 31 papers are published from the twelfth and thirteenth centuries belonging to the Cistercian monastery of Santa Maria de Melon, specifically those that permit the reconstruction of old possessions, focusing on the current council of O Porriño -which was the monastery of San Miguel de Cans, absorbed by the cistercian monks of Melon. A paleographic and historical approximation of this documentation is done, which is complemented with the corresponding index of names and place names.

    [gl] Trala introducción e criterios de transcripción, edítanse 31 documentos dos séculos XII e XIII pertencentes ó mosteiro cisterciense de Santa María de Melón, concretamente aqueles que permiten reconstruír as antigas posesións –centradas sobre o actual concello de O Porriño- do que foi o mosteiro de San Miguel de Cans, absorvido polos monxes cistercienses de Melón. Faise unha aproximación paleográfica e histórica da documentación, que se complementa cos correspondentes índices onomásticos e toponímicos.

  3. Los fines de la presencia de la Orden del Hospital en Castilla (Siglos XII y XIII = The objectives of the presence of the Order of the Hospital in Castile during the 12th and 13th Centuries

    Directory of Open Access Journals (Sweden)

    Carlos Barquero Goñi

    2015-06-01

    Full Text Available Las fuentes nos informan muy poco acerca de la suerte que tenían los recursos obtenidos por la Orden del Hospital de sus posesiones en la Corona de Castilla durante los siglos XII y XIII. Con toda seguridad lo primero en que debían utilizarse estas sumas era en el mantenimiento de todas las instalaciones y miembros de la Orden en Castilla y León. Lo que sobrase después de esto se habría de emplear en cuatro partidas distintas: aportaciones al convento central del Hospital en Oriente, actividad militar en la propia Corona de Castilla, desempeño de funciones asistenciales y propiamente hospitalarias, y soporte para algunas operaciones financieras.The sources provide us with scarce information on the use of resources obtained by the Order of the Hospital from its possessions in the Crown of Castile during the twelfth and thirteenth centuries. There is no doubt that this wealth was destined in the first place for the maintenance of all the facilities and members of the Order in Castile and Leon. What remained thereafter would be allocated to four different areas: Contributions to the central convent of the Hospital in the East; military activity within the Crown of Castile itself; coverage of welfare and specifically hospitaller functions; and support for certain financial operations.

  4. Report: Ordine del sentire e apertura al mondo. Filosofia delle emozioni e processo di individuazione della persona XIII Convegno internazionale della Max-Scheler-Gesellschaft Università di Verona 27-30 Maggio 2015

    Directory of Open Access Journals (Sweden)

    Maria Teresa Speranza

    2015-06-01

    Full Text Available An interesting debate on the issue of personal identity and its ethical implications has animated the days of the XIII International Congress of Max Scheler‐Gesellschaft. A large program of work has garnered numerous perspectives on the philosophy of person and the phenomenology of otherness, investigating in particular the role of emotions in the formation of person process. The main topic of conference was the Max Scheler’s phenomenology of emotions, which is an important turning point in the philosophy of twentieth century. The formation of ordo amoris, or rather order of feeling, generates the self‐transcendence of the immediate feeling in virtue, in which the person realizes her singularity. The emotion, therefore, doesn’t remain confined in a state of mind and inner private but acts in the world, creating the emotional breakthrough (emotioneller Durchbruch that makes me exist in a new way in the world, which allows me to act according to my ordo amoris.

  5. Pigment Cell Differentiation in Sea Urchin Blastula-Derived Primary Cell Cultures

    Science.gov (United States)

    Ageenko, Natalya V.; Kiselev, Konstantin V.; Dmitrenok, Pavel S.; Odintsova, Nelly A.

    2014-01-01

    The quinone pigments of sea urchins, specifically echinochrome and spinochromes, are known for their effective antioxidant, antibacterial, antifungal, and antitumor activities. We developed in vitro technology for inducing pigment differentiation in cell culture. The intensification of the pigment differentiation was accompanied by a simultaneous decrease in cell proliferation. The number of pigment cells was two-fold higher in the cells cultivated in the coelomic fluids of injured sea urchins than in those intact. The possible roles of the specific components of the coelomic fluids in the pigment differentiation process and the quantitative measurement of the production of naphthoquinone pigments during cultivation were examined by MALDI and electrospray ionization mass spectrometry. Echinochrome A and spinochrome E were produced by the cultivated cells of the sand dollar Scaphechinus mirabilis in all tested media, while only spinochromes were found in the cultivated cells of another sea urchin, Strongylocentrotus intermedius. The expression of genes associated with the induction of pigment differentiation was increased in cells cultivated in the presence of shikimic acid, a precursor of naphthoquinone pigments. Our results should contribute to the development of new techniques in marine biotechnology, including the generation of cell cultures producing complex bioactive compounds with therapeutic potential. PMID:24979272

  6. Nuclear Cryogenic Propulsion Stage

    Science.gov (United States)

    Houts, Michael G.; Borowski, S. K.; George, J. A.; Kim, T.; Emrich, W. J.; Hickman, R. R.; Broadway, J. W.; Gerrish, H. P.; Adams, R. B.

    2012-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced NEP.

  7. Fire on Stage

    Directory of Open Access Journals (Sweden)

    Nicholas Daly

    2017-12-01

    Full Text Available The nineteenth century theatre was fire-prone, to say the least. Across the century there were more than 1,100 major conflagrations in the world’s theatres, and countless smaller fires. In Great Britain almost every theatre seems to have burned down at some point. And yet, despite, or perhaps in part because of, this appalling record, fires were a staple feature of stage spectacle. Some plays placed them at the very centre of the entertainment, and as the century went on stage fires became more and more elaborate. Actual or simulated conflagrations were conjured up using a diverse array of technologies, some of them very simple, some depending on the most recent scientific discoveries. Here, I give a short tour of these technologies and their use in the plays of the period, and suggest some of the pleasures that they offered. While onstage flames could draw people in, offering an experience of immersive suspense, for instance, they also interrupted the dramatic flow, reminding audiences that they were seeing a performance, getting something for their money. To this extent, we are reminded that nineteenth-century drama provided something of a mixed and spectacular ‘theatre of attractions’, closer at times to the circus than to the novel.

  8. The principles of cancer staging.

    Science.gov (United States)

    Brierley, James; Gospodarowicz, Mary; O'Sullivan, Brian

    2016-01-01

    The anatomic disease extent or tumour stage of a cancer at diagnosis as a determinant of prognosis is discussed. The importance of cancer stage in individual patient prognosis and determination of treatment is reviewed as well as its value in research and cancer control activities. The conflict between the need for stability of cancer stage definitions over time and the need to evolve with advances in medicine are examined. The e cancer elearning modules on Cancer Stage are introduced.

  9. O perfil do empreendedor social e seu papel na continuidade de instituições do terceiro setor: o caso da Assistência Social Diocesana LeãoXIII de Passo Fundo – RS.

    Directory of Open Access Journals (Sweden)

    Ana Claúdia Machado Padilha

    2009-05-01

    Full Text Available O empreendedorismo tem sido abordado, cada vez mais, por organizações sem fins lucrativos que buscam excelência nas suas ações sociais. O estudo apresenta os resultados empíricos constituídos do perfil dos gestores da Assistência Social Diocesana Leão XIII, à luz dos conceitos do empreendedorismo social e os resultados alcançados ao longo do tempo na comunidade em que atua. Para isso, foram realizadas entrevistas com os três gestores e oito alunos da Escola Profissionalizante e aplicados questionários aos dez coordenadores dos núcleos e treze adolescentes assistidos pela Instituição. Na etapa da análise dos dados, foi utilizada a técnica de análise do conteúdo das respostas dos questionários e entrevistas segundo os critérios da literatura selecionada. Dentre os resultados significativos, percebeu-se que os gestores apresentaram um perfil alinhado ao sugerido pela literatura do empreendedorismo social, que converge para as ações pretendidas pela Instituição: trabalham em equipe; têm iniciativa para desenvolver as ações empreendedoras, apesar de não possuírem autonomia; são comprometidos com a causa social e indignam-se com as desigualdades sociais; são persistentes, responsáveis e têm senso de solidariedade.

  10. Fundamentos históricos e teóricos da noção de soberania: a contribuição dos "Papas juristas" do século XIII

    Directory of Open Access Journals (Sweden)

    Raquel Kritsch

    2010-12-01

    Full Text Available O objetivo deste artigo é discutir a contribuição do pensamento eclesiástico medieval tardio para a formação do conceito de soberania. Como o Estado moderno, tal conceito tem uma gênese demorada: é parte de um processo de transformação jurídica e política, do qual resulta um novo mapeamento do poder e das lealdades na Europa. A conformação desse novo sistema de poder tem como contrapartida a constituição de uma nova ordem jurídica. Essa ordem redefine os vínculos de comando e obediência, constituindo unida des políticas como áreas de jurisdição exclusiva e estabelecendo, entre essas unidades, relações de igualdade: nenhuma se reconhece como subordinada a outra. Todas essas questões podem ser entendidas como disputas de jurisdição. Trata-se de saber quem julga e quem pune delitos civis ou violações de normas religiosas. Os poderes de legislar, de mudar a lei, de resolver como últi ma instância e de controlar o uso da violência constituem o que os autores modernos nomearam soberania. Apontar a contribuição dos chamados Papas juristas do século XIII para a formulação de alguns elementos centrais a esta definição é a tarefa a ser leva da a cabo neste estudo.

  11. Breves considerações sobre a contratação direta de instituições de pesquisa com base no artigo 24, inciso XIII, da lei n.º 8.666/93 e a súmula 250 do TCU

    Directory of Open Access Journals (Sweden)

    Simone Coêlho Aguiar

    2009-06-01

    Full Text Available O artigo versa sobre a interpretação do art. 24, inciso XIII, da Lei n.º 8666/1993, em conjunto com a Súmula n.º 250 do Tribunal de Contas da União, e fundamenta-se, para tanto, na doutrina e na  jurisprudência relacionadas à matéria, buscando, através dessa abordagem, afastar as dúvidas que permeiam o tema e destacar a importância da atuação dos Tribunais de Contas no sentido de coibir o uso equivocado desse dispositivo legal.

  12. Science on stage

    Science.gov (United States)

    Ciceri, Piera

    2017-04-01

    Pictures and diaries of the legendary Antarctic Expedition of sir E. Shackleton and his crew aboard the Endurance (1914/16) have become the starting point to learn about Natural Science, Earth Science and Climate Change. Students, 12 years old, were involved in hands on activities, took part to a network project, used interactive virtual labs, talked to university researchers on Skype and became the writers of a play. The theater was the place to act the story of Shackleton's expedition, to "stage" some scientific experiments and to tell to the audience about ice cores, climate change, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The project was carried out from teachers of science, letters, geography and English in collaboration with the "Piccolo Teatro di Milano", the association "Scienza Under 18", researchers of the "Byrd Polar and Climate Research Center of Ohio State University" and of "M. Zucchelli Station" based in Antarctica. In our opinion drama activities improve both verbal and non-verbal communication skills and soft skills such as teamwork, responsibility and commitment. To be able to write and to act, students need a deep understanding of contents. To have an audience different from their own teachers and classmates and to interact with university researchers offer real tasks. The project aims to develop a relevant skill for the students: to become awareness citizens in a changing word.

  13. Science on stage

    CERN Document Server

    2005-01-01

    During the opening ceremony, the audience was dazzled by a juggling show involving dramatic light effects. They also took away with them a teacher's sheet explaining some of the scientific concepts involved in juggling. Science teachers can sometimes be quite humorous when it comes to explaining serious matters, as those who took part in the 'Science on Stage' festival held at CERN from 21 to 25 November were able to see for themselves. The 500 or so participants from 27 different countries, mostly science teachers but also some university lecturers, science outreach specialists and students, had the opportunity to share their experience of the teaching of science. They also attended presentations and shows, took part in workshops and visited a fair with stands offering ideas on how to make school science lessons more appealing. The festival, organised by the EIROforum (a partnership between CERN, EFDA, ESA, ESO, EMBL, ESRF and ILL), marked the end of two years of projects for the promotion of science in vir...

  14. Activation peptide of the coagulation factor XIII (AP-F13A1) as a new biomarker for the screening of colorectal cancer.

    Science.gov (United States)

    Peltier, Julien; Roperch, Jean-Pierre; Audebert, Stéphane; Borg, Jean-Paul; Camoin, Luc

    2018-01-01

    Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the primary diagnosis. Early diagnosis is closely associated with enhanced survival rate. We therefore investigated the AP-F13A1 as a potential protein marker of CRC. The protein expression of FXIII in 40 serum samples was evaluated by enzyme-linked immunosorbent assays. Additionally, targeted proteomic assays (LC-PRM) were used to evaluate the expression of the activation peptide of F13A1 (AP-F13A1) in a further 113 serum samples. Results were analyzed by the Wilcoxon test and receiver operating characteristic curves generated to assess statistical differences and diagnostic factors between CRC patients and controls. AP-F13A1 was quantified in human serum samples using calibration curves with excellent linearity. AP-F13A1 was reduced in CRC patients using PRM assays from two distinct biobanks. The AUC for AP-F13A1 were 0.95 and 0.93. Sensitivity/specificity values for the two sets of patients were 75%/95% and 71%/95% respectively. We have presented the proof of principle that in vivo release of AP-F13A1 can be measured by PRM-based strategies in CRC serum samples. AP-F13A1 may be an effective serological biomarker as part of a screening program of CRC detection.

  15. Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII.

    Directory of Open Access Journals (Sweden)

    Miglė Kišonaitė

    Full Text Available The early stage of drug discovery is often based on selecting the highest affinity lead compound. To this end the structural and energetic characterization of the binding reaction is important. The binding energetics can be resolved into enthalpic and entropic contributions to the binding Gibbs free energy. Most compound binding reactions are coupled to the absorption or release of protons by the protein or the compound. A distinction between the observed and intrinsic parameters of the binding energetics requires the dissection of the protonation/deprotonation processes. Since only the intrinsic parameters can be correlated with molecular structural perturbations associated with complex formation, it is these parameters that are required for rational drug design. Carbonic anhydrase (CA isoforms are important therapeutic targets to treat a range of disorders including glaucoma, obesity, epilepsy, and cancer. For effective treatment isoform-specific inhibitors are needed. In this work we investigated the binding and protonation energetics of sixteen [(2-pyrimidinylthioacetyl]benzenesulfonamide CA inhibitors using isothermal titration calorimetry and fluorescent thermal shift assay. The compounds were built by combining four sulfonamide headgroups with four tailgroups yielding 16 compounds. Their intrinsic binding thermodynamics showed the limitations of the functional group energetic additivity approach used in fragment-based drug design, especially at the level of enthalpies and entropies of binding. Combined with high resolution crystal structural data correlations were drawn between the chemical functional groups on selected inhibitors and intrinsic thermodynamic parameters of CA-inhibitor complex formation.

  16. Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII

    Science.gov (United States)

    Kišonaitė, Miglė; Zubrienė, Asta; Čapkauskaitė, Edita; Smirnov, Alexey; Smirnovienė, Joana; Kairys, Visvaldas; Michailovienė, Vilma; Manakova, Elena; Gražulis, Saulius; Matulis, Daumantas

    2014-01-01

    The early stage of drug discovery is often based on selecting the highest affinity lead compound. To this end the structural and energetic characterization of the binding reaction is important. The binding energetics can be resolved into enthalpic and entropic contributions to the binding Gibbs free energy. Most compound binding reactions are coupled to the absorption or release of protons by the protein or the compound. A distinction between the observed and intrinsic parameters of the binding energetics requires the dissection of the protonation/deprotonation processes. Since only the intrinsic parameters can be correlated with molecular structural perturbations associated with complex formation, it is these parameters that are required for rational drug design. Carbonic anhydrase (CA) isoforms are important therapeutic targets to treat a range of disorders including glaucoma, obesity, epilepsy, and cancer. For effective treatment isoform-specific inhibitors are needed. In this work we investigated the binding and protonation energetics of sixteen [(2-pyrimidinylthio)acetyl]benzenesulfonamide CA inhibitors using isothermal titration calorimetry and fluorescent thermal shift assay. The compounds were built by combining four sulfonamide headgroups with four tailgroups yielding 16 compounds. Their intrinsic binding thermodynamics showed the limitations of the functional group energetic additivity approach used in fragment-based drug design, especially at the level of enthalpies and entropies of binding. Combined with high resolution crystal structural data correlations were drawn between the chemical functional groups on selected inhibitors and intrinsic thermodynamic parameters of CA-inhibitor complex formation. PMID:25493428

  17. Staged membrane oxidation reactor system

    Science.gov (United States)

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh

    2012-09-11

    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  18. Staged Repository Development Programmes

    International Nuclear Information System (INIS)

    Isaacs, T

    2003-01-01

    Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to maximize the

  19. Second stage gasifier in staged gasification and integrated process

    Science.gov (United States)

    Liu, Guohai; Vimalchand, Pannalal; Peng, Wan Wang

    2015-10-06

    A second stage gasification unit in a staged gasification integrated process flow scheme and operating methods are disclosed to gasify a wide range of low reactivity fuels. The inclusion of second stage gasification unit operating at high temperatures closer to ash fusion temperatures in the bed provides sufficient flexibility in unit configurations, operating conditions and methods to achieve an overall carbon conversion of over 95% for low reactivity materials such as bituminous and anthracite coals, petroleum residues and coke. The second stage gasification unit includes a stationary fluidized bed gasifier operating with a sufficiently turbulent bed of predefined inert bed material with lean char carbon content. The second stage gasifier fluidized bed is operated at relatively high temperatures up to 1400.degree. C. Steam and oxidant mixture can be injected to further increase the freeboard region operating temperature in the range of approximately from 50 to 100.degree. C. above the bed temperature.

  20. Análisis de la elección de la pierna de ataque predominante en la prueba de 400 m vallas de los XIII Campeonatos del Mundo de Atletismo Daegu 2011

    Directory of Open Access Journals (Sweden)

    José Luis López del Amo

    2012-12-01

    Full Text Available Objetivos: Analizar la utilización de una u otra pierna como pierna de ataque predominante en atletas de 400 m vallas de alto nivel. Método: El estudio es descriptivo de corte transversal. Se estudiaron todas las carreras de 400 m vallas de los 72 participantes (34 hombres y 38 mujeres en los XIII Campeonatos del Mundo de Atletismo Daegu 2011, mediante la grabación en video desde la tribuna principal del Daegu Stadium de las 18 carreras de 400 m vallas disputadas, y el posterior análisis mediante la aplicación informática Kinovea 0.8.4. Resultados: Por atletas, en el total de las carreras masculinas, la pierna de ataque predominante fue la izquierda con un 63,6 % (42 atletas y con la pierna derecha hubo un 34,8 % (23 atletas. Solo en un caso había un equilibrio entre izquierda y derecha. En la final hubo un 75 % (6 atletas cuya pierna predominante de ataque fue la izquierda. En cuanto a las mujeres, la pierna de ataque predominante fue la izquierda con un 48,6 % seguida de la pierna derecha con un 41,4 % y para el 10 % había un equilibrio de las dos. En la final, en cambio, la pierna predominante de ataque fue la derecha con un 87,5 % (7 atletas por un 12,5 % de la izquierda (1 sola atleta. Se encontraron diferencias significativas (p = 0,018 en la media de tiempo final de los atletas masculinos según cual fuera su pierna de ataque. Conclusiones: La mayoría de los atletas atacan las vallas con derecha e izquierda en algún momento de la carrera, lo que obliga al dominio técnico bilateral. La pierna de ataque más utilizada es la izquierda, aunque en menor medida en el caso de las mujeres. Por primera vez en una gran competición, 7 de las 8 finalistas tienen la pierna derecha como pierna predominante.

  1. "Notae in cartulis" en la documentación madrileña del siglo XIII : contribución al estudio de la elaboración del documento privado en Castilla

    Directory of Open Access Journals (Sweden)

    María Teresa Carrasco Lazareno

    1997-01-01

    Full Text Available Edición y análisis diplomático de tres «notae in cartulis» o notas preparatorias del documento definitivo, redactadas en hojas sueltas de pergamino, pertenecientes a la colección del convento de Santo Domingo el Real de Madrid. Datadas en la segunda mitad del siglo xiii y escritas por «scriptores» profesionales, antecedentes inmediatos del «publicus notarius», resumen los aspectos esenciales de dos apeos y de una permuta. Estas «notae» tienen interés como antecedentes de las minutas y de los protocolos notariales y por ser escasos los testimonios originales conservados. Además, nos permiten constatar que la validez jurídica de la nota en la etapa prenotarial —aún no «scriptura matrix»— podía ser similar a la de la «scriptura originalis», pues en estos casos no debieron redactarse las correspondientes cartas, siendo la nota el único título acreditativo de la consecución del negocio jurídico.Edition and diplomatic analysis of tíiree «notae in cartulis» or preparatory notes of the final document, written on loóse sheet of parchment, from the documentary resources of the monastery of Saint Dominio the Royal in Madrid. Dated in the second part of the thirteenth century and written by professional «scriptores», inmediate precedent of the «publicus notarius», they sum up the most esential aspects of two fixing of boundaries and one barter. These «notae» are important considered as an antecedent of notes and notarial registers, being quite rare the original testimonies kept. Besides, the allow us to confirm that the «notae» juridical validity in the prenotarial phase —not yet «scriptura matrix»— could be similar to the «scriptura originalis», because in these cases the respective documents were not written, being the note the only evidential title of the juridical «negotium» obtaining.

  2. La Historia Roderici en su aspecto léxico: Estudio comparativo en relación con la Chronica Adefonsi Imperatoris y las crónicas hispanolatinas anteriores al siglo XIII

    Directory of Open Access Journals (Sweden)

    Estrella Pérez Rodríguez

    2013-06-01

    Full Text Available Este trabajo profundiza en el aspecto léxico de la Historia Roderici (y parcialmente también en el de la Chronica Adefonsi Imperatoris, teniendo como punto de comparación el resto de las crónicas hispanolatinas compuestas antes del siglo XIII. Se estudia la variedad del léxico empleado y su capacidad de innovación, dentro de la que se han identificado 66 términos no presentes en ninguna otra crónica hispana del período. El rastreo de estos vocablos en las fuentes medievales literarias europeas y en los diplomas hispanos ha llevado a observar que algunos no se utilizaron antes de finales del siglo XII, lo que apoya una fecha tardía para la obra. Asimismo el estudio ha permitido proponer alguna modificación en el texto editado de la Historia y también ha puesto en evidencia que su autor tenía un buen conocimiento del lenguaje notarial y procedía de la parte oriental de Hispania, muy posiblemente de la ya apuntada Nájera.Cet article présente une étude lexicale de l’Historia Roderici (et aussi partiellement de la Chronica Adefonsi imperatoris et la compare avec les autres chroniques hispaniques écrites avant le XIIIe siècle. Il souligne la richesse lexicale de l'œuvre, puisque l’Historia emploie 66 mots qui ne se trouvent pas ailleurs dans la production historiographique des royaumes espagnols de cette époque. L’auteur a étudié l’emploi de ces mots dans les textes littéraires écrits hors de la Péninsule Ibérique et dans les documents hispaniques et a vérifié que quelques uns n’apparaissent qu’à la fin du XIIe siècle. Ce résultat indique qu’une date de composition tardive de l’Historia est vraisemblable. L’étude propose aussi des modifications du texte de l’Historia tel qu'il a été édité jusqu'à présent, et démontre que l'auteur connaissait bien le langage notarial et qu’il était originaire de la partie orientale de l’Espagne, probablement de Nájera, comme on l'avait déjà avancé.

  3. Control of stage by stage changing linear dynamic systems

    Directory of Open Access Journals (Sweden)

    Barseghyan V.R.

    2012-01-01

    Full Text Available In this paper, the control problems of linear dynamic systems stage by stage changing and the optimal control with the criteria of quality set for the whole range of time intervals are considered. The necessary and sufficient conditions of total controllability are also stated. The constructive solving method of a control problem is offered, as well as the definitions of conditions for the existence of programmed control and motions. The explicit form of control action for a control problem is constructed. The method for solving optimal control problem is offered, and the solution of optimal control of a specific target is brought.

  4. Two-Stage Centrifugal Fan

    Science.gov (United States)

    Converse, David

    2011-01-01

    Fan designs are often constrained by envelope, rotational speed, weight, and power. Aerodynamic performance and motor electrical performance are heavily influenced by rotational speed. The fan used in this work is at a practical limit for rotational speed due to motor performance characteristics, and there is no more space available in the packaging for a larger fan. The pressure rise requirements keep growing. The way to ordinarily accommodate a higher DP is to spin faster or grow the fan rotor diameter. The invention is to put two radially oriented stages on a single disk. Flow enters the first stage from the center; energy is imparted to the flow in the first stage blades, the flow is redirected some amount opposite to the direction of rotation in the fixed stators, and more energy is imparted to the flow in the second- stage blades. Without increasing either rotational speed or disk diameter, it is believed that as much as 50 percent more DP can be achieved with this design than with an ordinary, single-stage centrifugal design. This invention is useful primarily for fans having relatively low flow rates with relatively high pressure rise requirements.

  5. Firebag stages 3 and 4

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, Heather [Suncore Energy (Canada)

    2011-07-01

    In this presentation, Suncor Energy Inc. outlines the current and projected future status of their growth in the oil production industry. Under a new partnership with Total, Suncor has seen growth of 10% in its oil sands operations. Firebag stages 3 and 4 were fully sanctioned in 2008 for 125kbbl/day as a feed source for the Voyageur upgrader in 2010/2012. Although the projects were suspended in 2009, due to difficulties in the economy, safety strategies were put in place and the projects were subsequently restarted. Suncor's aim was to meet new expectations with respect to safety, timing, and costs. Currently, construction of Stage 3 is near completion, with most of the plant in turnover and start-up mode. Stage 4 construction is also making good progress with new safety plans, workforce planning, and repeat contractors. Future plans include the completion of stages 3 and 4, scheduling and strategy for stages 5 and 6, and program approaches for key elements of growth (engineering, construction, and labor shortages).

  6. Planck 2013 results. XIII. Galactic CO emission

    CERN Document Server

    Ade, P.A.R.; Alves, M.I.R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartlett, J.G.; Battaner, E.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J. -P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J.J.; Bonaldi, A.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R.C.; Cardoso, J. -F.; Catalano, A.; Chamballu, A.; Chary, R. -R.; Chen, X.; Chiang, L. -Y; Chiang, H.C.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J. -M.; Dempsey, J.T.; Desert, F. -X.; Dickinson, C.; Diego, J.M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enblin, T.A.; Eriksen, H.K.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Fukui, Y.; Galeotta, S.; Ganga, K.; Giard, M.; Giraud-Heraud, Y.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Handa, T.; Hansen, F.K.; Hanson, D.; Harrison, D.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hily-Blant, P.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Hurier, G.; Jaffe, T.R.; Jaffe, A.H.; Jewell, J.; Jones, W.C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J. -M.; Lasenby, A.; Laureijs, R.J.; Lawrence, C.R.; Leonardi, R.; Leon-Tavares, J.; Lesgourgues, J.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Mandolesi, N.; Maris, M.; Marshall, D.J.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschenes, M. -A.; Moneti, A.; Montier, L.; Moore, T.J.T.; Morgante, G.; Morino, J.; Mortlock, D.; Munshi, D.; Nakajima, T.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Okuda, T.; Osborne, S.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G.W.; Preezeau, G.; Prunet, S.; Puget, J. -L.; Rachen, J.P.; Reach, W.T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubino-Martin, J.A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Spencer, L.D.; Starck, J. -L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A. -S.; Sygnet, J. -F.; Tauber, J.A.; Tavagnacco, D.; Terenzi, L.; Thomas, H.S.; Toffolatti, L.; Tomasi, M.; Torii, K.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L.A.; Wandelt, B.D.; Wehus, I.K.; Yoda, H. Yamamoto T.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-10-29

    Rotational transition lines of CO play a major role in molecular radio astronomy and in particular in the study of star formation and the Galactic structure. Although a wealth of data exists in the Galactic plane and some well-known molecular clouds, there is no available CO high sensitivity all-sky survey to date. Such all-sky surveys can be constructed using the \\Planck\\ HFI data because the three lowest CO rotational transition lines at 115, 230 and 345 GHz significantly contribute to the signal of the 100, 217 and 353 GHz HFI channels respectively. Two different component separation methods are used to extract the CO maps from Planck HFI data. The maps obtained are then compared to one another and to existing external CO surveys. From these quality checks the best CO maps in terms of signal to noise and/or residual foreground contamination are selected. Three sets of velocity-integrated CO emission maps are produced: Type 1 maps of the CO (1-0), (2-1), and (3-2) rotational transitions with low foreground ...

  7. Planck 2013 results. XIII. Galactic CO emission

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.

    2014-01-01

    component separation methods are used to extract the CO maps from Planck HFI data. The maps obtained are then compared to one another and to existing external CO surveys. From these quality checks the best CO maps, in terms of signal to noise ratio and/or residual contamination by other emission......, are selected. Three different sets of velocity-integrated CO emission maps are produced with different trade-offs between signal-to-noise, angular resolution, and reliability. Maps for the CO J = 1 -> 0, J = 2 -> 1, and J = 3 -> 2 rotational transitions are presented and described in detail. They are shown...

  8. Planck 2015 results. XIII. Cosmological parameters

    CERN Document Server

    Ade, P.A.R.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartlett, J.G.; Bartolo, N.; Battaner, E.; Battye, R.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R.C.; Calabrese, E.; Cardoso, J.F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chiang, H.C.; Chluba, J.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Desert, F.X.; Di Valentino, E.; Dickinson, C.; Diego, J.M.; Dolag, K.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T.A.; Eriksen, H.K.; Farhang, M.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Gerbino, M.; Ghosh, T.; Giard, M.; Giraud-Heraud, Y.; Giusarma, E.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J.E.; Hamann, J.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K.M.; Hurier, G.; Jaffe, A.H.; Jaffe, T.R.; Jones, W.C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Leahy, J.P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P.M.; Macias-Perez, J.F.; Maggio, G.; Mandolesi, N.; Mangilli, A.; Marchini, A.; Martin, P.G.; Martinelli, M.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Meinhold, P.R.; Melchiorri, A.; Melin, J.B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Millea, M.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T.J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Reach, W.T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; d'Orfeuil, B.Rouille; Rowan-Robinson, M.; Rubino-Martin, J.A.; Rusholme, B.; Said, N.; Salvatelli, V.; Salvati, L.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M.D.; Serra, P.; Shellard, E.P.S.; Spencer, L.D.; Spinelli, M.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Turler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L.A.; Wandelt, B.D.; Wehus, I.K.; White, M.; White, S.D.M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-01-01

    We present results based on full-mission Planck observations of temperature and polarization anisotropies of the CMB. These data are consistent with the six-parameter inflationary LCDM cosmology. From the Planck temperature and lensing data, for this cosmology we find a Hubble constant, H0= (67.8 +/- 0.9) km/s/Mpc, a matter density parameter Omega_m = 0.308 +/- 0.012 and a scalar spectral index with n_s = 0.968 +/- 0.006. (We quote 68% errors on measured parameters and 95% limits on other parameters.) Combined with Planck temperature and lensing data, Planck LFI polarization measurements lead to a reionization optical depth of tau = 0.066 +/- 0.016. Combining Planck with other astrophysical data we find N_ eff = 3.15 +/- 0.23 for the effective number of relativistic degrees of freedom and the sum of neutrino masses is constrained to < 0.23 eV. Spatial curvature is found to be |Omega_K| < 0.005. For LCDM we find a limit on the tensor-to-scalar ratio of r <0.11 consistent with the B-mode constraints fr...

  9. XIII. Un extraño Robinson

    OpenAIRE

    Ordinaire, Olivier

    2015-01-01

    *** Hubiera querido ver nuevamente a los Lorenzos que no habían hecho más que aparecer y desaparecer delante de la casa del cauchero y, con este propósito, hice una caminata de dos días a través del bosque, guiado por Pu-chuna que era decididamente mi amigo. No encontramos más en el lugar que chozas incendiadas y miserables plantaciones de plátanos invadidas por la vegetación. En cambio, la expedición me reservaría una extraña sorpresa. Al seguir la orilla de un riachuelo, afluente por la izq...

  10. XIII Modave Summer School in Mathematical Physics

    Science.gov (United States)

    2017-09-01

    The Modave Summer School on Mathematical Physics is a yearly summer school in topics of theoretical physics. Various topics ranging from quantum gravity and cosmology to theoretical particle physics and string theory. The school takes place in Modave, a charming village in the Belgian Ardennes close to Huy. Modave School is organised by PhD students for PhD students, and this makes it rather unique. The courses are taught by Post-Docs or late PhD students, and they are all made of pedagogical, basic blackboard lectures about recent topics in theoretical physics. Participants and lecturers eat and sleep in the same place where the lectures are given. The absence of senior members, and the fact of spending day and night together in an isolated, peaceful place contribute to creating an informal atmosphere and facilitating interactions. Lectures of the thirteenth edition are centered around the following subjects: bulk reconstruction in AdS/CFT, twistor theory, AdS_2/CFT_1 and SYK, geometry and topology, and asymptotic charges.

  11. Planck 2015 results: XIII. Cosmological parameters

    DEFF Research Database (Denmark)

    Ade, P. A R; Aghanim, N.; Arnaud, M.

    2016-01-01

    is constrained to w =-1.006 ± 0.045, consistent with the expected value for a cosmological constant. The standard big bang nucleosynthesis predictions for the helium and deuterium abundances for the best-fit Planck base ΛCDM cosmology are in excellent agreement with observations. We also constraints...

  12. Progress in ultrafast intense laser science XIII

    CERN Document Server

    III, Wendell; Paulus, Gerhard

    2017-01-01

    This thirteenth volume covers a broad range of topics from this interdisciplinary research field, focusing on atoms, molecules, and clusters interacting in intense laser field and high-order harmonics generation and their applications. The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, the interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each their own subfields of UILS. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries.   .

  13. DIRECT COUPLED PROGRESSIVE STAGE PULSE COUNTER APPARATUS

    Science.gov (United States)

    Kaufman, W.M.

    1962-08-14

    A progressive electrical pulse counter circuit was designed for the counting of a chain of input pulses of random width and/or frequency. The circuit employs an odd and even pulse input line alternately connected to a series of directly connected bistable counting stages. Each bistable stage has two d-c operative states which stage, when in its rnrtial state, prevents the next succeeding stage from changing its condition when the latter stage is pulsed. Since only altennate stages are pulsed for each incoming pulse, only one stage will change its state for each input pulse thereby providing prog essive stage by stage counting. (AEC)

  14. PET in lung cancer staging

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, R. E. [Duke University Medical Center, Dept. of Radiology, Durham, NC (United States)

    2001-09-01

    The primary clinical application of FDG-PET is in the evaluation of patients with lung cancer and includes diagnosis, staging and restaging of non-small cell lung cancer. PET has a very high accuracy (sensitivity=97%, specificity=78%) for characterizing nodules that are indeterminate by chest radiograph and computed tomography. The major utility of PET in the evaluation of patients with lung cancer is the staging of the entire body. PET is more accurate than the conventional imaging modalities of CT and bone scans in the detection of metastatic disease. PET is accurate in the staging of the mediastinum, adrenal glands, and the skeletal system. PET is not as accurate in the detection of brain metastases because of their small size and the normal cortical accumulation.

  15. Early stage fuel cell funding

    International Nuclear Information System (INIS)

    Bergeron, C.

    2004-01-01

    'Full text:' Early stage venture funding requires an in depth understanding of both current and future markets as well as the key technical hurdles that need to be overcome for new technology to commercialize into successful products for mass markets. As the leading fuel cell and hydrogen investor, Chrysalix continuously reviews global trends and new technologies, evaluates them with industry leaders worldwide and tries to match them up with the best possible management teams when selecting its early stage investments. Chrysalix Energy Limited Partnership is an early-stage venture capital firm focusing on fuel cell and related fueling technology companies and is a private equity joint venture between Ballard Power Systems, BASF Venture Capital, The BOC Group, The Boeing Company, Duke Energy, Mitsubishi Corporation and Shell Hydrogen. Operating independently, Chrysalix offers a unique value proposition to its clients throughout the business planning, start-up and operations phases of development. Chrysalix provides early-stage funding to new companies as well as management assistance, technological knowledge, organized networking with industry players and experience in the management of intellectual property. (author)

  16. Stages of neuronal network formation

    Science.gov (United States)

    Woiterski, Lydia; Claudepierre, Thomas; Luxenhofer, Robert; Jordan, Rainer; Käs, Josef A.

    2013-02-01

    Graph theoretical approaches have become a powerful tool for investigating the architecture and dynamics of complex networks. The topology of network graphs revealed small-world properties for very different real systems among these neuronal networks. In this study, we observed the early development of mouse retinal ganglion cell (RGC) networks in vitro using time-lapse video microscopy. By means of a time-resolved graph theoretical analysis of the connectivity, shortest path length and the edge length, we were able to discover the different stages during the network formation. Starting from single cells, at the first stage neurons connected to each other ending up in a network with maximum complexity. In the further course, we observed a simplification of the network which manifested in a change of relevant network parameters such as the minimization of the path length. Moreover, we found that RGC networks self-organized as small-world networks at both stages; however, the optimization occurred only in the second stage.

  17. Metrics for Stage Lighting Technology.

    Science.gov (United States)

    Cooper, Gloria S., Ed; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of stage lighting technology students, this instructional package is one of five for the arts and humanities occupations cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational terminology,…

  18. Stages of Merkel Cell Carcinoma

    Science.gov (United States)

    ... tissue. Merkel cells are in the layer of basal cells at the deepest part of the epidermis and are connected to nerves. Merkel cell carcinoma tends to grow quickly and to metastasize (spread) at an early stage . It usually spreads first to nearby lymph nodes and then may spread to lymph nodes or ...

  19. When science takes centre stage

    CERN Multimedia

    2005-01-01

    The teachers at 'Science on stage' are not emotionally attached to their chalk. Neither are they are weary old men who sport tweed jackets with elbow-patches and enter into conversation with their blackboards. Actually, 'Science on stage' teachers are far from the cliché of the boring physics teacher who can only inspire yawns from his pupils. Some present the basic principles of mechanics using a bicycle, others explain chemistry with examples from everyday life. The most audacious of them go so far as to explain the Doppler effect by means of a play in which Einstein dreams about jumping cows... These are but a few of the activities and plays that will be shown during the EIROforum1 Science on Stage Festival (organised by 7 European scientific organisations including CERN), to be held from 21 to 25 November at CERN, Geneva. This festival is dedicated to the teaching science in order to make it more attractive. After the first edition 'Physics on Stage' which was held in 2000 at CERN, the laboratory agai...

  20. Operation of staged membrane oxidation reactor systems

    Science.gov (United States)

    Repasky, John Michael

    2012-10-16

    A method of operating a multi-stage ion transport membrane oxidation system. The method comprises providing a multi-stage ion transport membrane oxidation system with at least a first membrane oxidation stage and a second membrane oxidation stage, operating the ion transport membrane oxidation system at operating conditions including a characteristic temperature of the first membrane oxidation stage and a characteristic temperature of the second membrane oxidation stage; and controlling the production capacity and/or the product quality by changing the characteristic temperature of the first membrane oxidation stage and/or changing the characteristic temperature of the second membrane oxidation stage.

  1. Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer

    Science.gov (United States)

    Lefringhouse, Jason; Pavlik, Edward; Miller, Rachel; DeSimone, Christopher; Ueland, Frederick; Kryscio, Richard; van Nagell, J. R.

    2014-01-01

    Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC) and SEER institutions. Results. Cytoreduction to no visible disease (P < 0.0001) and complete response to platinum-based chemotherapy (P < 0.025) occurred more frequently in Stage IIIA than in Stage IIIC cases. Time to progression was shorter in patients with Stage IIIC ovarian cancer (17 ± 1 months) than in those with Stage II1A disease (36 ± 8 months). Five-year overall survival (OS) improved from 41% in Stage IIIC patients to 60% in Stage IIIA patients treated at UKMCC and from 37% to 56% in patients treated at SEER institutions for a survival advantage of 19% in both data sets. 53% of Stage IIIA and 14% of Stage IIIC patients had NED at last followup. Conclusions. Decreasing stage at detection from Stage IIIC to stage IIIA epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor cytoreduction and platinum-based chemotherapy. PMID:25254047

  2. Staging N0 oral cancer

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Grupe, Peter

    2005-01-01

    PURPOSE: To compare sentinel lymph node biopsy, magnetic resonance imaging (MRI), Doppler ultrasonography, and palpation as staging tools in patients with T1/T2 N0 cancer of the oral cavity. MATERIAL AND METHODS: Forty consecutive patients were enrolled (17 F and 23 M, aged 32-90 years), 24 T1...... and 16 T2 cN0 squamous cell carcinoma of the oral cavity. Palpation was carried out by two observers prior to inclusion. MRI, gray-scale and Doppler ultrasonography were performed. Lymphoscintigraphies were done after peritumoral injections of 99mTc labelled rheniumsulphide nanocolloid, followed......%, but the sensitivity of MRI 36% was low. The specificities were 100%, 85%, and 93%, respectively. By combined sentinel lymph node biopsy and ultrasonography the overall sensitivity could have been 100%. CONCLUSION: Sentinel lymph node biopsy improved staging of patients with small N0 oral cancers. Combined sentinel...

  3. Sleep stages, memory and learning.

    Science.gov (United States)

    Dotto, L

    1996-04-15

    Learning and memory can be impaired by sleep loss during specific vulnerable "windows" for several days after new tasks have been learned. Different types of tasks are differentially vulnerable to the loss of different stages of sleep. Memory required to perform cognitive procedural tasks is affected by the loss of rapid-eye-movement (REM) sleep on the first night after learning occurs and again on the third night after learning. REM-sleep deprivation on the second night after learning does not produce memory deficits. Declarative memory, which is used for the recall of specific facts, is not similarly affected by REM-sleep loss. The learning of procedural motor tasks, including those required in many sports, is impaired by the loss of stage 2 sleep, which occurs primarily in the early hours of the morning. These findings have implications for the academic and athletic performance of students and for anyone whose work involves ongoing learning and demands high standards of performance.

  4. Acute pancreatitis: staging with CT

    International Nuclear Information System (INIS)

    Gialeli, E.; Petrocheilou, G.; Georgaki, S.; Tzemailas, I.; Adraktas, A.; Charilas, G.; Patsiogiannis, V.

    2012-01-01

    Full text: Introduction: Computed Tomography (CT) is the imaging modality of choice for the diagnosis and staging of acute pancreatitis and its complications. Objectives and tasks: The purpose of this presentation is to demonstrate the findings in CT images which are useful for staging acute pancreatitis according to Balthazar, their significance and restrictions. Materials and methods: CT images from patients who were referred to our Department for an abdominal CT scan for the diagnosis or/and staging of acute pancreatitis were retrospectively studied. Results: In acute pancreatitis, CT helps to stage the severity of inflammatory process, to detect pancreatic necrosis and to depict local complications. CT severity index (CTSI), which was proposed by Balthazar et al, combines the grade of pancreatitis with the extent of pancreatic necrosis assigning points to the patients in order to find the severity index which scales from 0-10. More points are given for a higher grade of pancreatitis and for more extensive necrosis. Types of pancreatitis according to CTSI are: interstitial (Balthazar grade A-C), exudative (Balthazar grade D or E), necrotising (Balthazar grade E, CTSI:10) and central gland necrotising. Patients with pancreatitis but no collections or necrosis have an interstitial (mild) pancreatitis. In exudative pancreatitis there is normal enhancement of the entire pancreas associated with extensive peripancreatic collections. Necrotizing (severe) pancreatitis is characterized by protacted clinical course, high incidence of local complications and high mortality rate. Central gland necrosis is a subtype of necrotizing pancreatitis. Conclusions: The combination of CT imaging and clinical and laboratory evaluation allows the early diagnosis of acute pancreatitis. Acute pancreatitis may vary from a mild uneventful disease to a severe life-threatening illness with multisystemic organ failure. Thus, it is crucial to identify patients who are at high risk of severe

  5. Patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Mavarkar Laxman

    2001-01-01

    Full Text Available Parapsoriasis is aeon troversial topic. There are many studies regarding the relationship of parapsoriasis to lymphoma but no correlation between histology and clinical appearance. Parapsoriasis satisfies histologic criteria for mycosis fungoides and therefore it should be considered as patch stage of mycosis fungoides. A 30-year-old man presented with scaly skin lesions over the trunk since 4 years. Routine blood and urine investigations were normal. Skin biopsy from the lesion revealed atypical lymphocytes within the epidermis without spongiosis.

  6. Images of gastric cancer stages

    International Nuclear Information System (INIS)

    Castro Aragon, I.M.

    1999-01-01

    The present work has the objective to review the importance of the images in the preoperating stage of the gastric cancer. It has been emphasized in the modalities of transabdominal ultrasound as much as endoscopic and TAC since they are most valuable in the stage. Certainly the importance of conventional radiology (gastroduodenal series) is also valuable in the stage of the tumor, specially in considering the depth of the same one. In order to make this overhaul, the recent bibliography was consulted but, specially the published one by Japaneses since they follow a classification and methodology different from the used one in most of the countries that belong to the World-wide Organization of the Health. They made an overhaul of approximately 200 cases of patients who have been diagnosed and treated in the Center of Detection of Gastric Cancer of Cartago. In each case review the file, radiological, sonographic and pathological studies, and the cases were chosen that better illustrated the exposed subjects. (Author) [es

  7. MR staging of endometrial carcinoma

    International Nuclear Information System (INIS)

    Innocenti, P.; Agostini, S.; Erroi, C.; Ambrogetti, D.; Cellerini, A.; Nori, J.

    1991-01-01

    Biopsy is the technique of choice for the definitive diagnosis of endometrial carcinoma. Since lymphatic tumor spread has been demonstrated to depend on the degree of myometrial involvement, the definition of the latter with imaging techniques may significantly affect both pfognosis and therapy. We investigated, by means of MR imaging at 0.5 T, 14 patients with endometrial carcinoma, to assess both tumor stage and myometrial involvement. FIGO staging system was employed, and M parameter evaluated (M0= no myometrial involvement; M1involvement confined to the inner third; M2= Involvement confined to the middle third; M3= involvement of the whole myometrium). Another parameter was the characteristic high signal of the tumor on PD and T2W images. The patients were then operated and MR information was correlated with surgical findings. Overall diagnostic accuracy of MR imaging was 85.7% in tumor staging, and 92.2% in defining M parameter. Tumor spread into adnexa and into cervical canal was poorly demonstrated by MR imaging

  8. Single conversion stage amplifier - SICAM

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  9. Preoperative staging of rectal cancer.

    Science.gov (United States)

    Smith, Neil; Brown, Gina

    2008-01-01

    Detailed preoperative staging using high resolution magnetic resonance imaging (MRI) enables the selection of patients that require preoperative therapy for tumour regression. This information can be used to instigate neoadjuvant therapy in those patients with poor prognostic features prior to disturbing the tumour bed and potentially disseminating disease. The design of trials incorporating MR assessment of prognostic factors prior to therapy has been found to be of value in assessing treatment modalities and outcomes that are targeted to these preoperative prognostic subgroups and in providing a quantifiable assessment of the efficacy of particular chemoradiation treatment protocols by comparing pre-treatment MR staging with post therapy histology assessment. At present, we are focused on achieving clear surgical margins of excision (CRM) to avoid local recurrence. We recommend that all patients with rectal cancer should undergo pre-operative MRI staging. Of these, about half will have good prognosis features (T1-T3b, N0, EMVI negative, CRM clear) and may safely undergo primary total mesorectal excision. Of the remainder, those with threatened or involved margins will certainly benefit from pre-operative chemoradiotherapy with the aim of downstaging to permit safe surgical excision. In the future, our ability to recognise features predicting distant failure, such as extramural vascular invasion (EMVI) may be used to stratify patients for neo-adjuvant systemic chemotherapy in an effort to prevent distant relapse. The optimal pre-operative treatment regimes for these patients (radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy) is the subject of current and future trials.

  10. [Initial stages of steel biocorrosion].

    Science.gov (United States)

    Zhigletsova, S K; Rodin, V B; Kobelev, V S; Aleksandrova, N V; Rasulova, G E; Kholodenko, V P

    2000-01-01

    Initial stages of corrosion of mild steel induced by Klebsiela rhinoscleromatis BO2 were studied in various media. The effect of the microorganism was detected 8-10 h after inoculation. The number of viable cells were virtually unchanged within one month in all media, but the corrosive activity of the strain decreased. The corrosive activity of microorganisms can be determined by spectrophotometry even only after incubation for 24 h. At a low level of organic substrate, even strong colonization with microorganisms does not inevitably result in a significant damage to metals.

  11. Staging Urban Experiences in Suburbia

    DEFF Research Database (Denmark)

    Jantzen, Christian; Vetner, Mikael

    2009-01-01

    Urban design provides props, requisites and decors for staging the users' performances in space. Design may facilitate or impede specific ways of moving around, interacting with objects and other people, feeling, learning and sense making.The actual design may very well contradict the explicit...... intentions of decision makers when commissioning, financing or planning new urban environments. Our case, the building of a new city centre for the Dutch city of Almere, illustrates this point. The project was supervised by Rem Koolhaas (OMA) and aimed at branding the city as a truly urban environment...

  12. Preadaptive Stage for Flight Origin

    Directory of Open Access Journals (Sweden)

    Bogdanovich I. A.

    2017-04-01

    Full Text Available Bipedalism as a preadaptive stage for bird’s flight is considered. We attribute the formation of full bipedalism in bird ancestors with pelvic limbs transition from segmental to parasagittal position. This transition was fast enough. We can assume that the pectoral limbs freed from the support remained while laterally spaced and gave set of transformations with different degrees of reduction. Thus morphologically “winglike” version of the thoracic limbs could appear. Parasagittal pelvic limbs allowed birds ancestors fast and maneuverable running, while the movements of free and highly movable thoracic limbs (feathered unrelated to flight provided dynamic stability of the animal. In addition, their fluttering movements facilitate hopping from one branch to another and the descent from the trees. On the bottom branches protobirds could jump with perching just by the pelvic anisodactyl limbs, not by thoracic as had supposed earlier. Active interaction of the primary simple feathers with air as well as its protective function could become an impetus for their transformation into differentiated structures. Unlike gliding (as preadaptive stage for active flight bipedalism with free feathered forelimbs provides per se parallel development of two autonomous enough locomotor systems of birds (flight and terrestrial locomotion and extensive adaptive radiation of representatives of the class.

  13. A simplified staging system based on the radiological findings in different stages of ochronotic spondyloarthropathy

    International Nuclear Information System (INIS)

    Jebaraj, Isaac; Chacko, Binita Riya; Chiramel, George Koshy; Matthai, Thomas; Parameswaran, Apurve

    2013-01-01

    This study describes a group of 26 patients with ochronotic spondyloarthropathy who were on regular treatment and follow-up at a tertiary level hospital and proposes a simplified staging system for ochronotic spondyloarthropathy based on radiographic findings seen in the thoracolumbar spine. This proposed classification makes it easy to identify the stage of the disease and start the appropriate management at an early stage. Four progressive stages are described: an inflammatory stage (stage 1), the stage of early discal calcification (stage 2), the stage of fibrous ankylosis (stage 3), and the stage of bony ankylosis (stage 4). To our knowledge, this is the largest reported series of radiological description of spinal ochronosis, and emphasizes the contribution of the spine radiograph in the diagnosis and staging of the disease

  14. Embryonic development and larval stages of Steindachneridion parahybae (Siluriformes: Pimelodidae: implications for the conservation and rearing of this endangered Neotropical species

    Directory of Open Access Journals (Sweden)

    Renato M. Honji

    2012-01-01

    Full Text Available Steindachneridion parahybae is a freshwater catfish endemic to the Paraíba do Sul River and is classified as an endangered Neotropical species. An increasing number of conservation biologists are incorporating morphological and physiological research data to help conservation managers in rescue these endangered species. This study investigated the embryonic and larval development of S. parahybae in captivity, with emphasis in major events during the ontogeny of S. parahybae. Broodstocks were artificially induced to reproduce, and the extrusion occurred 200-255 degree-hours after hormonal induction at 24°C. Larval ontogeny was evaluated every 10 minutes under microscopic/stereomicroscopic using fresh eggs samples. The main embryogenic development stages were identified: zygote, cleavage, including the morula, blastula, gastrula phase, organogenesis, and hatching. The extruded oocytes showed an average diameter of 1.10 ± 0.10 mm, and after fertilization and hydration of eggs, the average diameter of eggs increased to about 1.90 ± 0.60 mm, characterized by a large perivitelline space that persisted up to embryo development, the double chorion, and the poles (animal and vegetative. Cell division started about 2 minutes after fertilization (AF, resulting in 2, 4, 8 (4 x 2 arrangement of cells, 16 (4 x 4, 32 (4 x 8 and 64 (2 x 4 x 8 cells. Furthermore, the blastula and gastrula stages followed after these cells divisions. The closed blastopore occurred at 11 h 20 min AF; following the development, the organogenetic stages were identified and subdivided respectively in: early segmentation phase and late segmentation phase. In the early segmentation phase, there was the establishment of the embryonic axis, and it was possible to distinguish between the cephalic and caudal regions; somites, and the optic vesicles developed about 20 h AF. Total hatching occurred at 54 h AF, and the larvae average length was 4.30 ± 0.70 mm. Gradual yolk sac reduction

  15. Early stages of Ostwald ripening

    Science.gov (United States)

    Shneidman, Vitaly A.

    2013-07-01

    The Becker-Döring (BD) nucleation equation is known to predict a narrow double-exponential front (DEF) in the distribution of growing particles over sizes, which is due to early transient effects. When mass conservation is included, nucleation is eventually exhausted while independent growth is replaced by ripening. Despite the enormous difference in the associated time scales, and the resulting demand on numerics, within the generalized BD model the early DEF is shown to be crucial for the selection of the unique self-similar Lifshitz-Slyozov-Wagner asymptotic regime. Being preserved till the latest stages of growth, the DEF provides a universal part of the initial conditions for the ripening problem, regardless of the mass exchange mechanism between the nucleus and the matrix.

  16. The Nuclear Cryogenic Propulsion Stage

    Science.gov (United States)

    Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen; Belvin, Anthony; Borowski, Stanley K.; Scott, John

    2014-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP). Nuclear propulsion can be affordable and viable compared to other propulsion systems and must overcome a biased public fear due to hyper-environmentalism and a false perception of radiation and explosion risk.

  17. Stage at diagnosis and ovarian cancer survival

    DEFF Research Database (Denmark)

    Maringe, Camille; Walters, Sarah; Butler, John

    2012-01-01

    We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival.......We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival....

  18. Interconnected Levels of Multi-Stage Marketing

    DEFF Research Database (Denmark)

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    must not only decide in general on the merits of multi-stage marketing for their firm, but must also decide on which level they will engage in multi-stage marketing. The triadic perspective enables a rich and multi-dimensional understanding of how different business relationships influence each other......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...... different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...

  19. Stages of Ovarian Low Malignant Potential Tumors

    Science.gov (United States)

    ... tests or procedures are used for staging. Staging laparotomy (a surgical incision made in the wall of ... treatment. Two types of standard treatment are used: Surgery The type of surgery (removing the tumor in ...

  20. Melhoramento do cafeeiro: XIII - Café bourbon amarelo Coffee breeding: XIII - yellow bourbon coffee

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1957-01-01

    Full Text Available Um conjunto de 30 plantas matrizes de Bourbon Amarelo foi selecionado em 1945, em Jaú, na propriedade "Fazendinha". As progênies dêsses cafeeiros foram plantadas nas Estações Experimentais do Instituto Agronômico em Campinas, Ribeirão Preto, Pindorama, Mococa e Jaú, em linhas de 20 plantas. Diversas observações foram feitas relativas ao desenvolvimento dos cafeeiros, produção e tipos de sementes. De maneira geral o desenvolvimento foi considerado muito bom, com exceção de Mococa, onde as plantas apresentaram porte e produção menores devido ao terreno mais pobre onde foram plantadas. Embora tenha havido variações acentuadas no comportamento das progênies quanto à produção, verificou-se que as de n. J 30, J 3, J 8, J 10, J 11 e J 24 classificaram-se como as melhores nas cinco localidades, ao fim de oito anos seguidos de produção. As melhores plantas das boas progênies já foram incluídas em campos de aumento e suas sementes vêm sendo distribuídas aos lavradores. Notou-se acentuada variação de produção anual do conjunto de progênies, principalmente a partir do quarto ano de colheita. As produções bienais cresceram até o terceiro biênio, estacionando ou diminuindo no quarto. Notou-se que algumas progénies são tardias na produção, de modo que não será aconselhável a seleção precoce de progênies de Bourbon Amarelo eliminando-se as menos produtivas logo após o primeiro biênio de produção. Verificou-se, também, que as plantas de maior produção total pertencem, em grande parte, a progênies que apresentam produção média geral elevada, as quais, por sua vez, possuem variabilidade menor de produção. A curva de distribuição da produção total das plantas individuais mostrou-se variável.nas diferentes localidades; em tôdas verificou-se a ocorrência de plantas muito pouco produtivas, com produções médias inferiores à média geral subtraída de 2,57 vezes o desvio padrão geral do lote. A ocorrência desse tipo de plantas é de 1,7% no Bourbon Amarelo, inferior à que se encontra no café Mundo Novo. Os dados referentes às porcentagens de sementes dos tipos moca e concha indicaram que não há excesso de sementes anormais. As sementes moca mostraram-se mais freqüentes em Ribeirão Prêto, e menos em Pindorama e Campinas. As sementes concha são mais freqüentes em Campinas e Pindorama, e menos em Ribeirão Prêto. Quanto à distribuição das porcentagens de sementes concha, notou-se maior variação em Campinas e Pindorama. Com relação à ocorrência da anomalia constituída por frutos com lojas desenvolvidas e sem sementes, verificou-se que é pouco freqüente no café Bourbon Amarelo e da mesma intensidade que a verificada em outras variedades comerciais, como Bourbon Vermelho e Caturra. A ocorrência de plantas com frutos alaranjados, heterozigotas para os alelos Xcxc, indicou que devem ser freqüentes os cruzamentos naturais no cafezal onde as plantas matrizes foram selecionadas, pois embora o número de plantas de frutos vermelhos (XcXc no local fôsse de freqüência reduzida em relação às plantas de frutos amarelos (xcxc, a ocorrência média de plantas heterozigotas entre os descendentes foi de 2,46%. Devido às características apresentadas por êsse grupo de progênies analisadas, tais como vigor vegetativo, alta produção e bom rendimento, confirma-se ser o Bourbon Amarelo uma variedade de café de bastante importância econômica, devendo suas seleções ser cultivadas em larga escala.Little is known about the origin of Yellow Bourbon coffee (Coffea arabica cv. Bourbon Amarelo, one of the most promising coffee varieties. It probably originated in the neighbourhood of Pederneiras, S. P. (Brazil, either as a mutation of Bourbon coffee (red fruits, or as a recombinant from an eventual natural hybridization between this variety and Amarelo de Botucatu (yellow fruits when ripe, which is a natural mutation of typica (C. arabica L. var. typica Cramer. In order to develop new strains of this variety, 30 outstanding mother trees were chosen in 1945, in a private plantation located in Jaú, S. P. These trees were selected mainly on the basis of their vigor, plant type and apparent yield at selection time. To secure vegetative propagation branches were taken from each selected mother tree and then grafted in Campinas. Open-pollinated seeds from each tree were planted at five experiment stations of the State of São Paulo, namely, Campinas, Ribeirão Prêto, Pindorama, Mococa, Jaú. These locations show differences in soil type, and slight dissimilarities in climatic conditions. Campinas is located in the "Terra roxa-misturada" soil type, Ribeirão Prêto and Jaú on "Terra-roxa" soil, Mococa on "Massapé", and Pindorama on "Arenito Bauru" soil. At the beginning of the rainy season of 1946 the seedlings were transplanted to the field. In each location 20 plants from each mother tree were grown in lines, without replications, with a single individual tree per "hill". Individual records were taken for the first 8 years of crop (1949-56. During two or three years nearly all plants were sampled in order to determine the percentages of normal, "moca" (peaberry and "concha" (elephant seeds, grade of normal beans, incidence of empty fruit locules, and, in Campinas only, the ratio between weight of ripe fruits and the weight of dry seeds from these fruits (out-turn, and the weight of a thousand normal beans. From tables 1, 6, 9, 12, 15 and 18 which summarize the annual yields of each progeny in five locations, it appears that the most promising progenies are those derived from mother trees J 30, J 3, J 8, J 10, J 11 and J 24. High yielding progenies tend to show less variability from year to year than lower yielding-groups. Outstanding trees among the highest yielding progenies have already been included in seed production plots, and their seeds are being released to farmers for the establishment of new plantations. All progenies presented growing yields, up to the fourth crop, after which a clear biennial bearing cycle took place. Total yields per biennium increased as a rule from the first to the sixth crop, decreasing slightly in the las two years (1955-56. It was noticed that Yellow Bourbon progenies as a rule are not so consistent in keeping their initial yield ranking, from the first four to the sixth or eighth crops, as it was shown to occur in the closely related Red Bourbon variety. This indicates that if the lowest yielding progenies were discarded on the basis of th'e first two years of crop, some late high yielding progenies would have been lost for selection at a later period. Six or eight consecutive crops may already give an indication of the best progenies and of the individual trees which are probably among those to be selected for their high yields. Out of the 30-highest yielding trees in Campinas, 70 per cent belong to progenies ranked among the first ten on the basis of progeny mean yields. In Ribeirão Preto, Pindorama, Mococa and Jaú these figures were 90, 73, 60 and 80 per cent, respectively. This seems to indicate that under these circunstances selection should rather be based on the average yields of progenies. Considering altogether the five groups of progenies in the different experiment stations, an average was found of less than 2 per cent of individual trees presenting reduced total yields, that is, less than x - 2,57 s. The study of seed samples revealed that the highest percentage of "moca" seed is that from Ribeirão Prêto and the lowest one those from Campinas and Pindorama. These two locations, however, presented the highest percentages of "concha", while in Ribeirão Prêto the incidence of this abnormality was the lowest. Tables 20 and 21 summarize the characteristics of the distributions of these individual percentages of "moca" and "concha" seeds. All plants were examined for the presence of empty fruit locules. The incidence of this abnormality is low, as it is normally found in commercial varieties such as Red Bourbon and Caturra. Out of 2,930 plants belonging to 30 progenies grown in five' locations, 82 or 2.57c had fruits of a light red colour, being heterozygotes Xcxc. These plants resulted, as expected, from natural cross-pollination in the original plot where the seeds of mother trees were collected. If taken as a measure of the amount of cross-pollination this percentage may be considered as relatively high, because few plants with red fruits (XcXc were noticed in the original plot of Yellow Bourbon. From these studies it may be concluded that due to their excellent agronomic characteristics the new strains of Yellow Bourbon coffee will have an outstanding place among the commercial varieties for the Brazilian coffee areas.

  1. Early-stage mantle cell lymphoma

    DEFF Research Database (Denmark)

    Dabaja, B S; Zelenetz, A D; Ng, A K

    2017-01-01

    Background: Mantle cell lymphoma (MCL) rarely presents as early-stage disease, but clinical observations suggest that patients who present with early-stage disease may have better outcomes than those with advanced-stage disease. Patients and methods: In this 13-institution study, we examined...

  2. Stages of tuberculous meningitis: a clinicoradiologic analysis

    International Nuclear Information System (INIS)

    Sher, K.; Firdaus, A.; Bullo, N.; Kumar, S.; Abbasi, A.

    2013-01-01

    Objective: To determine the frequencies and percentages of various clinicoradiologic variables of tuberculosis meningitis (TBM) with reference to British Medical Research Council (BMRC) staging of the disease. Study Design: A case series. Place and Duration of Study: Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, from October 2010 to September 2011. Methodology: The study included 93 adult patients with the diagnosis of tuberculous meningitis (TBM) at the study place. Patients were divided in three groups according to British Medical Research Council (BMRC) staging of TBM. Different clinical and radiological findings were analyzed at different stages of the disease. Data was analyzed using SPSS (Statistical Package of Social Sciences) version 11.0. Results: A majority of patients were found to be in stage-II disease at the time of admission. History of illness at the time of admission was more than 2 weeks in 50% of stage-I patients but around 80% in stage-II and stage-III patients. Neck stiffness was the most commonly reported finding in all stages. Cranial nerve palsies were higher in stage-III (75%) than in stage-II (43%) and in stage-I (24%) patients. Hydrocephalus and basal enhancement was the most frequently reported radiographic abnormalities. Conclusion: Duration of illness and cranial nerve palsies are important variables in the diagnosis of TBM stages and if TBM is suspected, empiric treatment should be started immediately without bacteriologic proof to prevent morbidity and mortality. (author)

  3. Two-Stage Series-Resonant Inverter

    Science.gov (United States)

    Stuart, Thomas A.

    1994-01-01

    Two-stage inverter includes variable-frequency, voltage-regulating first stage and fixed-frequency second stage. Lightweight circuit provides regulated power and is invulnerable to output short circuits. Does not require large capacitor across ac bus, like parallel resonant designs. Particularly suitable for use in ac-power-distribution system of aircraft.

  4. Stage control of tablets manufacturing

    Directory of Open Access Journals (Sweden)

    L. I. Kucherenko

    2014-08-01

    Full Text Available Today in Ukraine tuberculosis is the wide-spread infectious disease causing the death in most cases; about 700 thousand persons are suffering from it. In Ukraine epidemic of tuberculosis is progressing and spreading. In spite of all protective measures three inhabitants of our country contract tuberculosis per hour, every hour one patient dies and in common about 1.5% of the population is ill with tuberculosis. Isoniazid is antituberculous drug of the first line and it is the most effective one. Chemotherapy of tuberculosis requests long-lasting administration of antituberculous drugs that causes high risk of side effects. To prevent or lessen side effects of antituberculous medicines antioxidants use in complex therapy is perspective. Fulfilled investigations showed efficacy of combining two medical substances – isoniazid andthiotriazolin – in one dosage form. Objective.The aim of our investigation is working out the methods of standardization, in particularquantitative determination of isoniazid andthiotriazolin content in tablet mass by high-performance liquid chromatography (HPLC. Materials and Methods.During in-process investigations combined tableted remedy containing isoniazid andthiotriazolin and proper amount of adjuvants has been developed (it contains active substances isoniazid – 0.2 g,thiotriazolin – 0.05 g and adjuvants up to the 0.4 g of the tablet. During stage control of tablets manufacturingspecial attention is paid to the control of tablet mass quality. Especially it concerns quantitative determination of active substances in it. More and more attention is paid to modern physical-chemical methods of standardization in up-to-date analysis of drug products, such as ultraviolet spectrometry, high-performance liquid chromatography (HPLC etc. In previous scientific investigations we proved the possibility of standardization of active substances artificial compound by HPLC method and optimal conditions of analysis performing

  5. Two stage turbine for rockets

    Science.gov (United States)

    Veres, Joseph P.

    1993-01-01

    The aerodynamic design and rig test evaluation of a small counter-rotating turbine system is described. The advanced turbine airfoils were designed and tested by Pratt & Whitney. The technology represented by this turbine is being developed for a turbopump to be used in an advanced upper stage rocket engine. The advanced engine will use a hydrogen expander cycle and achieve high performance through efficient combustion of hydrogen/oxygen propellants, high combustion pressure, and high area ratio exhaust nozzle expansion. Engine performance goals require that the turbopump drive turbines achieve high efficiency at low gas flow rates. The low mass flow rates and high operating pressures result in very small airfoil heights and diameters. The high efficiency and small size requirements present a challenging turbine design problem. The shrouded axial turbine blades are 50 percent reaction with a maximum thickness to chord ratio near 1. At 6 deg from the tangential direction, the nozzle and blade exit flow angles are well below the traditional design minimum limits. The blade turning angle of 160 deg also exceeds the maximum limits used in traditional turbine designs.

  6. Acting Antarctica: science on stage

    Science.gov (United States)

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia

    2016-04-01

    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  7. One-Stage and Bayesian Two-Stage Optimal Designs for Mixture Models

    OpenAIRE

    Lin, Hefang

    1999-01-01

    In this research, Bayesian two-stage D-D optimal designs for mixture experiments with or without process variables under model uncertainty are developed. A Bayesian optimality criterion is used in the first stage to minimize the determinant of the posterior variances of the parameters. The second stage design is then generated according to an optimality procedure that collaborates with the improved model from first stage data. Our results show that the Bayesian two-stage D-D optimal design...

  8. Nursing leadership: a concise encyclopedia

    National Research Council Canada - National Science Library

    Feldman, Harriet R

    2008-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xvii Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxv...

  9. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components' final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  10. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components` final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  11. Compact 6-DOF Stage for Optical Adjustments

    Science.gov (United States)

    Shafaat, Syed; Chang, Daniel

    2008-01-01

    The figure depicts selected aspects of a six-degree-of-freedom (6-DOF) stage for mechanical adjustment of an optical component. The six degrees of freedom are translations along the Cartesian axes (x, y, and z) and rotations about these axes (theta x, theta y, and theta z, respectively). Relative to prior such stages, this stage offers advantages of compactness, stability, and robustness, plus other advantages as described below. The stage was designed specifically as part of a laser velocimeter and altimeter in which light reflected by a distant object is collected by a Cassegrainian telescope and focused into a single-mode, polarization-maintaining optical fiber. The stage is used to position and orient the input end of the optical fiber with respect to the focal point of the telescope. Stages like this one can also be adapted for use in positioning and orienting other optical components, including lenses, prisms, apertures, and photodetectors.

  12. Trading Stages: Life Expectancies in Structured Populations

    Science.gov (United States)

    Tuljapurkar, Shripad; Coulson, Tim; Horvitz, Carol

    2012-01-01

    Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied because they are hard to use and interpret, and tools for age and stage structured populations are missing. We present easily interpretable expressions for the sensitivities and elasticities of life expectancy to vital rates in age-stage models, and illustrate their application with two biological examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography. PMID:22664576

  13. Numerical simulation of radial compressor stage

    Science.gov (United States)

    Syka, T.; Luňáček, O.

    2013-04-01

    Article describes numerical simulations of air flow in radial compressor stage in NUMECA CFD software. In simulations geometry variants with and without seals are used. During tasks evaluating was observed seals influence on flow field and performance parameters of compressor stage. Also is described CFDresults comparison with results from design software based on experimental measurements and monitoring of influence of seals construction on compressor stage efficiency.

  14. Numerical simulation of radial compressor stage

    OpenAIRE

    Luňáček O.; Syka T.

    2013-01-01

    Article describes numerical simulations of air flow in radial compressor stage in NUMECA CFD software. In simulations geometry variants with and without seals are used. During tasks evaluating was observed seals influence on flow field and performance parameters of compressor stage. Also is described CFDresults comparison with results from design software based on experimental measurements and monitoring of influence of seals construction on compressor stage efficiency.

  15. Numerical simulation of radial compressor stage

    Directory of Open Access Journals (Sweden)

    Luňáček O.

    2013-04-01

    Full Text Available Article describes numerical simulations of air flow in radial compressor stage in NUMECA CFD software. In simulations geometry variants with and without seals are used. During tasks evaluating was observed seals influence on flow field and performance parameters of compressor stage. Also is described CFDresults comparison with results from design software based on experimental measurements and monitoring of influence of seals construction on compressor stage efficiency.

  16. Stage character of the oxidation of dialkylthiophenes

    Energy Technology Data Exchange (ETDEWEB)

    Volkov, M.N.; Kazakova, O.A.

    1988-07-20

    The reasons for the stage character of the oxidation of dialkylthiophenes catalyzed by a cobalt bromide catalyst are examined. The stage character of oxidation is due to the deactivation of the catalyst by the corresponding alcohol formed during oxidation. At the first stage of the process only the products from oxidation of the /alpha/-alkyl group, i.e., the corresponding ketone, ester, and thiophenecarboxylic acid, are formed. The rate constants for their formation were calculated.

  17. Life cycle analysis in preliminary design stages

    OpenAIRE

    Agudelo , Lina-Maria; Mejía-Gutiérrez , Ricardo; Nadeau , Jean-Pierre; PAILHES , Jérôme

    2014-01-01

    International audience; In a design process the product is decomposed into systems along the disciplinary lines. Each stage has its own goals and constraints that must be satisfied and has control over a subset of design variables that describe the overall system. When using different tools to initiate a product life cycle, including the environment and impacts, its noticeable that there is a gap in tools that linked the stages of preliminary design and the stages of materialization. Differen...

  18. Experiments for Multi-Stage Processes

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat

    2015-01-01

    Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize...... the required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any...

  19. Technology and staging effects on two-stage-to-orbit systems

    Science.gov (United States)

    Wilhite, Alan W.

    1991-01-01

    Horizontal takeoff and landing two-stage systems with an airbreathing first stage and rocket second stage are evaluated for staging Mach numbers that range from 5 to 14. All systems are evaluated with advanced technologies being developed in the NASP Program and sized to the same mission requirements. With these advanced technologies, the two-stage systems are heavier than the single stage. The weights of the two-stage systems are closely related to staging. Using a rocket on the first stage to accelerate from the turboramjet limit of Mach 6 to Mach 10 signiificantly decreases dry weight as compared to the Mach 6-staged system. The optimum dry weight staging Mach number for the scramjet two-stage system is Mach 12. At a 40 percent weight growth (current technology level), the scramjet two-stage systems are half the weight and less sensitive to weight changes than the single stage, but still require substantial technology development in the areas of inlets, nozzles, ramjet propulsion, active cooling, and high-temperature structures.

  20. Comparison of new AJCC staging system with old AJCC staging system in nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Se Mie; Wu, Hong Gyun; Park, Charn II [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2000-12-01

    This study was designed to examine the reliability of the new version of the AJCC staging system (1997) of nasopharyngeal carcinoma in comparison with the AJCC staging system of 1992. Between 1983 and 1996, 185 patients with histologically proven nasopharyngeal carcinoma were treated with radiation therapy at the Department of Therapeutic Radiology Seoul National University Hospital. For these patients, AJCC staging system of 1992 was compared with the 1997 version, by reviewing hospital records, computed tomography (CT) and/or magnetic resonance imaging (MRI). 5-year overall survival rates according to the 1992 and 1997 AJCC staging systems were 100%, and 100% at stage I; 100%, and 68.8% at stage ll;61.4%, and 63.8% at stage III; 61.1%, and 63.2% at stage IV. 5-year overall survival rates of each classification showed significant differences between stages (p=0.0049 for the old version, p=0.01 for the new), but no significant difference was found between the staging systems except at stage II. The new AJCC staging system allows staging as reliably as the 1992 version, but the adequacy of the newly modified staging classification should be confirmed by further clinical examination.

  1. One-stage and two-stage penile buccal mucosa urethroplasty

    Directory of Open Access Journals (Sweden)

    G. Barbagli

    2016-03-01

    Full Text Available The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa graft with the application of glue is preliminary showed and discussed. Two-stage penile urethroplasty is then reported. A detailed description of first-stage urethroplasty according Johanson technique is reported. A second-stage urethroplasty using buccal mucosa graft and glue is presented. Finally postoperative course and follow-up are addressed.

  2. Gene expression in early stage cervical cancer

    NARCIS (Netherlands)

    Biewenga, Petra; Buist, Marrije R.; Moerland, Perry D.; van Thernaat, Emiel Ver Loren; van Kampen, Antoine H. C.; ten Kate, Fiebo J. W.; Baas, Frank

    2008-01-01

    Objective. Pelvic lymph node metastases are the main prognostic factor for survival in early stage cervical cancer, yet accurate detection methods before surgery are lacking. In this study, we examined whether gene expression profiling can predict the presence of lymph node metastasis in early stage

  3. Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

    DEFF Research Database (Denmark)

    Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N

    2013-01-01

    This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

  4. Interrelations among SMED Stages: A Causal Model

    Directory of Open Access Journals (Sweden)

    José Roberto Díaz-Reza

    2017-01-01

    Full Text Available Mexico has received a lot of foreign investment that has brought in a wide range of novel production philosophies, such as Single Minute Exchange of Dies (SMED. Despite its popularity and reported effectiveness, Mexican companies often quit SMED implementation as they consider it challenging. This usually happens when organizations are not familiarized enough with each one of the SMED stages or do not know how they are interrelated. In this article the interrelations among the different SMED implementation stages by means of a structural equations model are analyzed. Data for constructing the model were gathered from a survey administered to 250 employees from the Mexican maquiladora industry. The survey assessed the importance of 14 activities belonging to the four SMED stages. The descriptive analyses of these stages were conducted and integrated into a structural equations model as latent variables, to find their level of dependency. The model was constructed using WarpPLS 5 software, and direct, indirect, and total effects among variables are analyzed and validated. Results from the model revealed that Stage 1 of SMED implementation, known as the Identification Stage, has both direct and indirect effects on all the other SMED stages, being the most important stage.

  5. Investigation of vanadium catalyst regeneration stages

    International Nuclear Information System (INIS)

    Tsarev, Yu.V.; Il'in, A.P.; Shirokov, Yu.G.

    1995-01-01

    Regeneration stages of vanadium catalyst: dissolution of spent catalyst in alkaline solution of potassium vanadate, precipitation and aging of hydrosilica gel, which passed to solution, have been studied experimentally. The influence of the stages on final activity and thermal stability of regenerated contact masses has been considered. 10 refs., 4 figs., 2 tabs

  6. Two-stage repair in hypospadias

    Directory of Open Access Journals (Sweden)

    K N Haxhirexha

    2008-01-01

    Full Text Available We provide the reader with a nonsystematic review concerning the use of the two-stage approach in hypospadias repairs. A one-stage approach using the tubularized incised plate urethroplasty is a well-standardized approach for the most cases of hypospadias. Nevertheless, in some primary severe cases, in most hypospadias failures and in selected patients with balanitis xerotica obliterans a two-stage approach is preferable. During the first stage the penis is straightened, if necessary and the urethral plate is substituted with a graft of either genital (prepuce or extragenital origin (oral mucosa or postauricular skin. During the second stage, performed around 6 months later, urethroplasty is accomplished by graft tubulization. Graft take is generally excellent, with only few cases requiring an additional inlay patch at second stage due to graft contracture. A staged approach allows for both excellent cosmetic results and a low morbidity including an overall 6% fistula rate and 2% stricture rate. Complications usually occur in the first year after the second stage and are higher in secondary repairs. Complications tend to decrease as experience increases and use of additional waterproofing layers contributes to reduce the fistula rate significantly. Long-term cosmetic results are excellent, but voiding and ejaculatory problems may occur in as much as 40% of cases if a long urethral tube is constructed. The procedure has a step learning curve but because of its technical simplicity does not require to be confined only to highly specialized centers.

  7. The construction of two-stage tests

    NARCIS (Netherlands)

    Adema, Jos J.

    1988-01-01

    Although two-stage testing is not the most efficient form of adaptive testing, it has some advantages. In this paper, linear programming models are given for the construction of two-stage tests. In these models, practical constraints with respect to, among other things, test composition,

  8. Bevalac injector final stage RF amplifier upgrades

    International Nuclear Information System (INIS)

    Howard, D.; Calvert, J.; Dwinell, R.; Lax, J.; Lindner, A.; Richter, R.; Ridgeway, W.

    1991-01-01

    With the assistance of the DOE In-house Energy Management Program, the Bevalac injector final stage RF amplifier systems have been successfully upgraded to reduce energy consumption and operating costs. This recently completed project removed the energy-inefficient plate voltage modulator circuits that were used in conjunction with the final stage RF amplifiers. Construction, design, and operating parameters are described in detail

  9. Transesophageal Ultrasonography for Lung Cancer Staging

    DEFF Research Database (Denmark)

    Konge, Lars; Annema, Jouke; Vilmann, Peter

    2013-01-01

    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging...

  10. The IASLC Lung Cancer Staging Project

    DEFF Research Database (Denmark)

    Chansky, Kari; Detterbeck, Frank C; Nicholson, Andrew G

    2017-01-01

    INTRODUCTION: Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally v...

  11. Teacher Concerns and Teacher Life Stages

    Science.gov (United States)

    Mok, Yan Fung

    2005-01-01

    This article examines teaching concerns at successive life stages among teachers with up to twenty years' or more teaching experience. Three concern stages are discerned. Nine common concern factors were found from factor-analysing thirty-three concern items. Results show that student discipline, relations with students, and students' learning and…

  12. Experiments for Multi-Stage Processes

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat

    2015-01-01

    the required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any......Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize...... number of stages and also show how to identify and estimate the effects. Both regular and non-regular designs are considered as base designs in generating the overall design....

  13. Sequential scintigraphic staging of small cell carcinoma

    International Nuclear Information System (INIS)

    Bitran, J.D.; Bekerman, C.; Pinsky, S.

    1981-01-01

    Thirty patients with small cell carcinoma (SCC) of the lung were sequentially staged following a history and physical exam with liver, bran, bone, and gallium-67 citrate scans. Scintigraphic evaluation disclosed 7 of 30 patients (23%) with advanced disease, stage IIIM1. When Gallium-67 scans were used as the sole criteria for staging, they proved to be accurate and identified six of the seven patients with occult metastatic disease. Gallium-67 scans proved to be accurate in detecting thoracic and extrathoracic metastases in the 30 patients with SCC, especially within the liver and lymph node-bearing area. The diagnostic accuracy of gallium-67 fell in regions such as bone or brain. Despite the limitations of gallium-67 scanning, the authors conclude that these scans are useful in staging patients with SCC and should be the initial scans used in staging such patients

  14. Stage-adjusted chemoradiation in cervical cancer after transperitoneal laparoscopic staging

    Energy Technology Data Exchange (ETDEWEB)

    Marnitz, S.; Bischoff, A.; Budach, V. [Charite Berlin (Germany). Dept. of Radiooncology; Koehler, C.; Roth, C.; Schneider, A. [Charite Berlin (Germany). Dept. of Gynecology; Fueller, J.; Wendt, T. [Jena Univ. (Germany). Dept. of Radiooncology

    2007-09-15

    Purpose: To evaluate the impact of transperitoneal laparoscopic staging on choice of subsequent therapy including oncologic outcome and toxicity of chemoradiation after surgical staging. Patients and Methods: 101 patients with cervical cancer FIGO IB1-IVB underwent chemoradiation after transperitoneal laparoscopic staging. Results: 101 women (FIGO IB1-IVB) were laparoscopically staged. In 68/101 patients, pelvic and/or paraaortic lymph node metastases were confirmed histologically. Only 17/101 patients (17%) retained their original FIGO stage after laparoscopy. Laparoscopic staging and chemoradiation were well tolerated. Laparoscopic debulking of tumor-involved lymph nodes resulted in significantly improved overall survival. Conclusion: In patients with cervical cancer, laparoscopic staging led to an upstaging of 83% of cases with significant impact on therapeutic strategies. Nodal debulking prior to chemoradiation improves the prognosis of node positive women. Pretherapeutic laparoscopic staging should be the basis of the primary chemoradiation in patients with cervical cancer. (orig.)

  15. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Hudson River: STAGING (Staging Site Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for staging sites along the Hudson River. Vector points in this data set represent locations of possible staging areas...

  16. Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

    DEFF Research Database (Denmark)

    Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin

    2001-01-01

    Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non......-reactive bubble point calculations is proposed. This strategy tracks the conversion and temperature between the feed and the end stages of the column. An illustrative example highlights the verification of the design strategy through rigorous simulation....

  17. Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey.

    Science.gov (United States)

    Oztuzcu, Serdar; Ergun, Sercan; Ulaşlı, Mustafa; Nacarkahya, Gülper; Iğci, Yusuf Ziya; Iğci, Mehri; Bayraktar, Recep; Tamer, Ali; Çakmak, Ecir Ali; Arslan, Ahmet

    2014-06-01

    Cardiovascular disease (CVD) risk factors, such as arterial hypertension, obesity, dyslipidemia or diabetes mellitus, as well as CVDs, including myocardial infarction, coronary artery disease or stroke, are the most prevalent diseases and account for the major causes of death worldwide. In the present study, 4,709 unrelated patients subjected to CVD panel in south-east part of Turkey between the years 2010 and 2013 were enrolled and DNA was isolated from the blood samples of these patients. Mutation analyses were conducted using the real-time polymerase chain reaction method to screen six common mutations (Factor V G1691A, PT G20210A, Factor XIII V34L, MTHFR A1298C and C677T and PAI-1 -675 4G/5G) found in CVD panel. The prevalence of these mutations were 0.57, 0.25, 2.61, 13.78, 9.34 and 24.27 % in homozygous form, respectively. Similarly, the mutation percent of them in heterozygous form were 7.43, 3.44, 24.91, 44.94, 41.09 and 45.66%, respectively. No mutation was detected in 92 (1.95%) patients in total. Because of the fact that this is the first study to screen six common mutations in CVD panel in south-east region of Turkey, it has a considerable value on the diagnosis and treatment of these diseases. Upon the results of the present and previous studied a careful examination for these genetic variants should be carried out in thrombophilia screening programs, particularly in Turkish population.

  18. El arte del buen morir en los testamentos medievales de la catedral de Sigüenza (siglos XIII-XV = The Art of Good Dying in the Medieval Wills of the Cathedral of Sigüenza (Thirteenth to Fifteenth Centuries

    Directory of Open Access Journals (Sweden)

    Aída Portilla González

    2016-06-01

    Full Text Available El presente artículo tiene como objeto contribuir al conocimiento de la religiosidad bajomedieval castellana y dilucidar las actitudes ante la muerte del hombre medieval. Con el propósito de esclarecer la mentalidad de los miembros privilegiados de la sociedad seguntina bajomedieval, tanto de laicos como de eclesiásticos, hemos analizado un grupo de testamentos conservados en el Archivo de la Catedral de Sigüenza de los siglos XIII, XIV y XV. Gracias a estos documentos oficiales podemos acercarnos a las concepciones sobre la vida y la muerte que imperaban en dicho contexto. En los testamentos quedan codificados los ritos y actitudes que el hombre utilizaba para transitar de la vida terrenal al más allá y  alcanzar la tan ansiada Salvación Eterna.This article contributes to the knowledge of Castilian medieval religious belief and to explain the attitudes of medieval man towards death. It aims at shedding light on the mentality of the privileged members of late medieval Sigüenza, both lay and clergymen, by studying a collection of wills preserved in the Sigüenza Cathedral Archive from the thirteenth, fourteenth and fifteenth centuries. Through these official documents we can begin to discern the ideas regarding life and death that prevailed in this context. These wills establish models of rites and attitudes that people adopted in order to go from earthly life to the afterlife and to reach the much-coveted eternal salvation.

  19. Los campesinos al servicio del señor, según los fueros locales burgaleses de los siglos XI-XIII = Peasants in the Service of the Lord according to Municipal Charters of Burgos from the Eleventh to the Thirteenth Century

    Directory of Open Access Journals (Sweden)

    Luis Martínez García

    2016-06-01

    Full Text Available En el presente trabajo se aborda la naturaleza y el alcance de los servicios debidos por los campesinos dependientes a sus respectivos señores, prestando especial atención a la renta señorial como parte integrante de la renta feudal. Para ello se cuenta con una serie de 50 fueros locales de los siglos XI al XIII pertenecientes a la actual provincia de Burgos. Por tratarse del marco legal en el que se desarrolló la vida laboral y social del campesinado, cada fuero en su localidad fijaba por escrito los servicios más comunes e importantes, entre otros, las infurciones, sernas, nuncios, mañerías, posada y yantar, así como otras formas distintas del servitium que convirtieron la dependencia campesina en un estado de vida permanente.In this paper we examine the nature and scope of the services owed by dependent peasants to their lords, with particular reference to lordship rents. We will examine a series of fifty municipal charters (fueros, consisting of all the extant records dating from the eleventh to the thirteenth centuries from the province of Burgos. As these charters detail the legal framework in which the peasantry’s economic and social life took place, each charter prescribed the most common and significant duties owed in their respective jurisdiction among which we find the following: infurción, serna, nuncio, mañería, posada and yantar, as well as other forms of servitium which transformed the peasantry’s state of dependency into a permanent way of life.

  20. Assessment of Stage 35 With APNASA

    Science.gov (United States)

    Celestina, Mark L.; Mulac, Richard

    2009-01-01

    An assessment of APNASA was conducted at NASA Glenn Research Center under the Fundamental Aeronautics Program to determine their predictive capabilities. The geometry selected for this study was Stage 35 which is a single stage transonic compressor. A speedline at 100% speed was generated and compared to experimental data at 100% speed for two turbulence models. Performance of the stage at 100% speed and profiles of several key aerodynamic parameters are compared to the survey data downstream of the stator in this report. In addition, hub leakage was modeled and compared to solutions without leakage and the available experimental data.

  1. Classification, staging and radiotherapy of bronchial carcinoma

    International Nuclear Information System (INIS)

    Noordijk, E.M.

    1983-01-01

    This thesis reports a study performed to evaluate the stage classification of bronchial carcinoma published by Thomas in 1963. The study was done in the radiotherapy department of a teaching hospital, and had three parts: a comparative analysis of the classifications and stage divisions described in the literature on bronchial carcinoma; an evaluation of the theoretical basis of the classification system introduced by Thomas as well as of the practical applicability of the division into stages, with respect to the assessment of the prognosis and the choice of therapy; and an analysis of various aspects of irradiation as well as of a number of prognostic factors in bronchial carcinoma. (Auth.)

  2. Nonlinear stage of Z-pinch instability

    International Nuclear Information System (INIS)

    Garanin, S.F.; Chernyshev, Yu.D.

    1987-01-01

    Nonlinear development of MHD instability of constriction type for Z-pinch with completely skinned current is considered. The two-dimensional numerical calculations of the constriction show that its development enters the stage described by automodel solution, when the constriction length is fixed and plasma compression takes place in an isentropic way. At the perturbation wave length small, as compared with pinch radius, the stage is preceded by a stage reduced to nonlinear Rayleigh-Taylor instability. For that case dynamics of the motion of magnetic field ''bubbles'' and plasma ''jets'' is considered. It is shown that plasma jets escaping from the pinch region do not close the pinch from current source

  3. Comparing Stage Presence and Virtual Reality Presence

    Directory of Open Access Journals (Sweden)

    Sebastian Xavier Samur

    2016-05-01

    Full Text Available Reflecting on the impending release of new Head Mounted Display virtual reality (VR technologies, the article examines definitions and techniques for digital presence, and compares them with research into stage presence. It opens with an outline of definitions of digital presence, comparing them with Cormac Power’s fictional, auratic, and literal modes of presence in performance. The article then looks at techniques used in VR and on stage to achieve presence. Finally, performance examples that use virtual reality technologies are presented. The article concludes that even if the technology falls short, discourse on digital presence is useful in providing insights into presence on stage.

  4. Developmental Stages in School Computer Use: Neither Marx Nor Piaget.

    Science.gov (United States)

    Lengel, James G.

    Karl Marx's theory of stages can be applied to computer use in the schools. The first stage, the P Stage, comprises the entry of the computer into the school. Computer use at this stage is personal and tends to center around one personality. Social studies teachers are seldom among this select few. The second stage of computer use, the D Stage, is…

  5. Design considerations for single-stage and two-stage pneumatic pellet injectors

    International Nuclear Information System (INIS)

    Gouge, M.J.; Combs, S.K.; Fisher, P.W.; Milora, S.L.

    1988-09-01

    Performance of single-stage pneumatic pellet injectors is compared with several models for one-dimensional, compressible fluid flow. Agreement is quite good for models that reflect actual breech chamber geometry and incorporate nonideal effects such as gas friction. Several methods of improving the performance of single-stage pneumatic pellet injectors in the near term are outlined. The design and performance of two-stage pneumatic pellet injectors are discussed, and initial data from the two-stage pneumatic pellet injector test facility at Oak Ridge National Laboratory are presented. Finally, a concept for a repeating two-stage pneumatic pellet injector is described. 27 refs., 8 figs., 3 tabs

  6. Comparative effectiveness of one-stage versus two-stage basilic vein transposition arteriovenous fistulas.

    Science.gov (United States)

    Ghaffarian, Amir A; Griffin, Claire L; Kraiss, Larry W; Sarfati, Mark R; Brooke, Benjamin S

    2018-02-01

    Basilic vein transposition (BVT) fistulas may be performed as either a one-stage or two-stage operation, although there is debate as to which technique is superior. This study was designed to evaluate the comparative clinical efficacy and cost-effectiveness of one-stage vs two-stage BVT. We identified all patients at a single large academic hospital who had undergone creation of either a one-stage or two-stage BVT between January 2007 and January 2015. Data evaluated included patient demographics, comorbidities, medication use, reasons for abandonment, and interventions performed to maintain patency. Costs were derived from the literature, and effectiveness was expressed in quality-adjusted life-years (QALYs). We analyzed primary and secondary functional patency outcomes as well as survival during follow-up between one-stage and two-stage BVT procedures using multivariate Cox proportional hazards models and Kaplan-Meier analysis with log-rank tests. The incremental cost-effectiveness ratio was used to determine cost savings. We identified 131 patients in whom 57 (44%) one-stage BVT and 74 (56%) two-stage BVT fistulas were created among 8 different vascular surgeons during the study period that each performed both procedures. There was no significant difference in the mean age, male gender, white race, diabetes, coronary disease, or medication profile among patients undergoing one- vs two-stage BVT. After fistula transposition, the median follow-up time was 8.3 months (interquartile range, 3-21 months). Primary patency rates of one-stage BVT were 56% at 12-month follow-up, whereas primary patency rates of two-stage BVT were 72% at 12-month follow-up. Patients undergoing two-stage BVT also had significantly higher rates of secondary functional patency at 12 months (57% for one-stage BVT vs 80% for two-stage BVT) and 24 months (44% for one-stage BVT vs 73% for two-stage BVT) of follow-up (P < .001 using log-rank test). However, there was no significant difference

  7. Shakespeare on the High School Stage.

    Science.gov (United States)

    Schlusberg, Julian S.

    1981-01-01

    Describes activities involved in the planning and production of Shakespeare's "Othello" in a high school. Outlines methods used to develop strong student motivation and involvement in class and on stage. (JMF)

  8. Treatment Options (by Stage) for Colon Cancer

    Science.gov (United States)

    ... types of surgery : Local excision or simple polypectomy . Resection and anastomosis . This is done when the tumor is too ... stage I colon cancer usually includes the following: Resection and anastomosis . Use our clinical trial search to find NCI- ...

  9. Laparoscopic ultrasonography for staging of gastrointestinal malignancy

    NARCIS (Netherlands)

    Gouma, D. J.; de Wit, L. T.; Nieveen van Dijkum, E.; van Delden, O.; Bemelman, W. A.; Rauws, E. A.; van Lanschot, J. J.; Obertop, H.

    1996-01-01

    BACKGROUND: Diagnostic laparoscopy has been used frequently as a preoperative staging procedure for different gastrointestinal malignancies. The assessment of solid abdominal organs and retroperitoneal ingrowth or detection of lymph-node metastasis is limited, however. A recent development,

  10. Treatment Options by Stage (Esophageal Cancer)

    Science.gov (United States)

    ... the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds , ... stage of the cancer being treated. External and internal radiation therapy are used to treat esophageal cancer. A plastic ...

  11. Treatment Options by Stage (Penile Cancer)

    Science.gov (United States)

    ... the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds , ... stage of the cancer being treated. External and internal radiation therapy are used to treat penile cancer. Chemotherapy Chemotherapy ...

  12. Staged Financing in Venture capital market.

    OpenAIRE

    Damania, Priti

    2009-01-01

    The report shows the venture capital decision making in staged financing from a real option perspective. The report also describes entrepreneur-venture capital relationship from a prisoner's dilemma approach.

  13. Konkurss "Sony Jazz Stage" otsib uusi talente

    Index Scriptorium Estoniae

    2006-01-01

    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt. www.jazzkaar.ee)

  14. INNOVATION DIFFUSION THEORY MAIN DEVELOPMENT STAGES

    Directory of Open Access Journals (Sweden)

    S. V. Lisafiev

    2011-01-01

    Full Text Available Abstract: Main innovation diffusion development theory stages are: Rogers model of moving new products to the market including characteristics of its segments; mathematic substantiation of this model by Bass; Moor model taking into account gaps between adjacent market segments; Goldenberg model making it possible to predict sales drops at new product life cycle initial stages. It is reasonable to use this theory while moving innovative products to the market.

  15. Theory of Economic Development (Secondary Stage)

    OpenAIRE

    Mashkoor, Aasim; Ahmed, Ovais

    2015-01-01

    This is a secondary stage of theory of economic development. This research study is covering the secondary phase of development which rules the tactical plans of the main strategy. In this stage, the social and economical demands varies from country to country and we have developed the theory according to the Pakistani economic conditions. It requires great a lot of technical and strategic analysis to chose the accurate plans accordingly.

  16. Comparisons of single-stage and two-stage approaches to genomic selection.

    Science.gov (United States)

    Schulz-Streeck, Torben; Ogutu, Joseph O; Piepho, Hans-Peter

    2013-01-01

    Genomic selection (GS) is a method for predicting breeding values of plants or animals using many molecular markers that is commonly implemented in two stages. In plant breeding the first stage usually involves computation of adjusted means for genotypes which are then used to predict genomic breeding values in the second stage. We compared two classical stage-wise approaches, which either ignore or approximate correlations among the means by a diagonal matrix, and a new method, to a single-stage analysis for GS using ridge regression best linear unbiased prediction (RR-BLUP). The new stage-wise method rotates (orthogonalizes) the adjusted means from the first stage before submitting them to the second stage. This makes the errors approximately independently and identically normally distributed, which is a prerequisite for many procedures that are potentially useful for GS such as machine learning methods (e.g. boosting) and regularized regression methods (e.g. lasso). This is illustrated in this paper using componentwise boosting. The componentwise boosting method minimizes squared error loss using least squares and iteratively and automatically selects markers that are most predictive of genomic breeding values. Results are compared with those of RR-BLUP using fivefold cross-validation. The new stage-wise approach with rotated means was slightly more similar to the single-stage analysis than the classical two-stage approaches based on non-rotated means for two unbalanced datasets. This suggests that rotation is a worthwhile pre-processing step in GS for the two-stage approaches for unbalanced datasets. Moreover, the predictive accuracy of stage-wise RR-BLUP was higher (5.0-6.1%) than that of componentwise boosting.

  17. Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

    Science.gov (United States)

    Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

    2015-01-01

    This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

  18. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer

    Directory of Open Access Journals (Sweden)

    Bumpers Harvey L

    2011-05-01

    Full Text Available Abstract Background Although evaluation of at least 12 lymph nodes (LNs is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs. Methods To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer, 490 patients were categorized into groups based on 1-6, 7-11, 12-19, and ≥ 20 LNs collected. Results For patients with Stage II or III disease, examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II (HR = 0.33; 95% CI, 0.12-0.91, but not for Stage III patients (HR = 1.59; 95% CI, 0.54-4.64, examination of ≥20 LNs was associated with a reduced risk of recurrence within 2 years. However, examination of ≥20 LNs had a 55% (Stage II, HR = 0.45; 95% CI, 0.23-0.87 and a 31% (Stage III, HR = 0.69; 95% CI, 0.38-1.26 decreased risk of mortality, respectively. For each six additional LNs examined from Stage III patients, there was a 19% increased probability of finding a positive LN (parameter estimate = 0.18510, p Conclusions Thus, the 12 LN cut-off point cannot be supported as requisite in determining adequate staging of colon cancer based on current data. However, a minimum of 6 LNs should be examined for adequate staging of Stage II and III colon cancer patients.

  19. Radiotherapy for stage IV oropharyngeal cancer

    International Nuclear Information System (INIS)

    Nakamura, Kaori; Akimoto, Tetsuo; Motegi, Atsushi

    2008-01-01

    Fifty-seven patients with stage IVA-B oropharyngeal cancer treated by definitive radiotherapy in our facility from January 1993 to August 2005 were retrospectively analyzed. The age of the patients was 34-84 (median 62) years old. Thirty-four were male and 14 were female. Subsite of the tumor was anterior: 16, lateral: 39, posterior: 1, and superior: 1. Forty-nine patients were treated with chemotherapy. Induction chemotherapy (ICT) was done in 25 patients, ICT+concurrent chemoradiotherapy (CCRT) in 15 patients, and CCRT in 9 patients. A dose of 60-82 Gy (median 72 Gy) by hyperfractionated radiotherapy, at 1.2 Gy/fraction twice a day, was delivered in 37 patients, and 60-72 Gy (median 66 Gy) with a conventional daily fractionation in 20 patients. Salvage surgery was performed in 5 patients as a part of primary treatment after radiotherapy. The 5-year cause-specific survival rate and disease-free survival rate were 52.9% and 51.4%, respectively. By univariate analysis, the impact of age, sex, T-stage, N-stage, histological differentiation, chemotherapy and fractionation of radiation therapy on survivals were evaluated. T-stage, N-stage and histological differentiation were significantly covariate correlated with survival. The treatment results were not satisfactory. Further investigation of the treatment strategy to improve the treatment outcome of advanced oropharyngeal cancer is desired. (author)

  20. Stage of Alcohol and Drug Use among Young Adults.

    Science.gov (United States)

    Werch, Chudley E.; And Others

    1994-01-01

    This study examined stages of drug habit acquisition and change among college students, basing the proposed stages of drug use on the Multi-Component Motivational Stages prevention model. Surveys indicated the model helped explain the stages of substance use. The proportion of youths at each stage differed by type of drug. (SM)

  1. Article mounting and position adjustment stage

    Science.gov (United States)

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved adjustment and mounting stage of the type used for the detection of laser beams is disclosed. A ring sensor holder has locating pins on a first side thereof which are positioned within a linear keyway in a surrounding housing for permitting reciprocal movement of the ring along the keyway. A rotatable ring gear is positioned within the housing on the other side of the ring from the linear keyway and includes an oval keyway which drives the ring along the linear keyway upon rotation of the gear. Motor-driven single-stage and dual (x, y) stage adjustment systems are disclosed which are of compact construction and include a large laser transmission hole.

  2. Early stage malignant phyllodes tumor case report.

    Science.gov (United States)

    Wolbert, Thao; Leigh, Emilia C N; Barry, Rahman; Traylor, Jack R; Legenza, Mary

    2018-01-01

    Malignant phyllodes tumor of the breast is an extremely rare entity usually presenting with similar clinical features with those of benign fibroadenoma. Due to its scarcity and clinical presentation, it is quite difficult for clinicians to suspect and diagnose the disease at its early stage. There is currently no consensus regarding adjunctive radiotherapy, hormonal therapy and systemic chemotherapy recommended for malignant phyllodes tumors. This report presents a case of early-stage malignant phyllodes tumor treated by lumpectomy only without adjunctive chemoradiation therapy, but with an excellent outcome. Early diagnosis and staging with high suspicion are crucial in malignant phyllodes tumor patients since they do not only improve the overall outcome of the disease after lumpectomy only but they also decrease morbidity and mortality with adjunctive chemoradiation therapy. This case report has been reported in line with the SCARE criteria (Agha et al., 2016 [1]). Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  3. The Stages of Implementing the Accounting Outsourcing

    Directory of Open Access Journals (Sweden)

    Liakhovych Halyna I.

    2017-04-01

    Full Text Available The article is aimed at substantiating the procedure for implementing the accounting outsourcing, determining its stages and phases, and to address the problematic issues that arise through the main phases. The general sequence of outsourcing of accounting functions has been disclosed. It has been proposed to allocate preparatory, technological and performance stages in the course of the accounting outsourcing process. It has been found that determining the procedure and organization of the transition to accounting outsourcing is crucial in ensuring its efficiency, so that greater emphasis is placed on the first stage. A sequence of actions in the substantiation of choice for outsourcing as a form of accounting organization has been determined. The list of criteria of choice from the enterprises-outsourcers for accounting record-keeping has been clarified.

  4. Comparative myoanatomy of cycliophoran life cycle stages

    DEFF Research Database (Denmark)

    Neves, Ricardo C.; Cunha, Maria R.; Funch, Peter

    2010-01-01

    The metazoan phylum Cycliophora includes small cryptic epibionts that live attached to the mouthparts of clawed lobsters. The life cycle is complex, with alternating sexual and asexual generations, and involves several sessile and free-living stages. So far, the morphological and genetic...... on the dorsal side, whereas on the ventral side, longitudinal muscles and a V-shaped muscle structure are present. These muscles are complemented by additional dorsoventral muscles. The mesodermal muscle fibers attach to the cuticle via the epidermis in all life cycle stages studied herein. The musculature...... of the female is similar to that of the Pandora larva of Symbion americanus and includes dorsoventral muscles and longitudinal muscles that run in the dorsal and ventral body region. Overall, our results reveal striking similarities in the muscular arrangement of the life cycle stages of both Symbion species. J...

  5. Alignment Stage for a Cryogenic Dilatometer

    Science.gov (United States)

    Dudik, Matthew; Moore, Donald

    2005-01-01

    A three-degree-of-freedom alignment stage has been designed and built for use in a cryogenic dilatometer that is used to measure thermal strains. The alignment stage enables precise adjustments of the positions and orientations of optical components to be used in the measurements and, once adjustments have been completed, keeps the components precisely aligned during cryogenic-dilatometer operations that can last as long as several days. The alignment stage includes a case, a circular tilt/tip platform, and a variety of flexural couplings between the case and the platform, all machined from a single block of the low-thermal-expansion iron/nickel alloy Invar, in order to minimize effects of temperature gradients and to obtain couplings that are free of stiction and friction. There are three sets of flexural couplings clocked at equal angles of 120 degrees around the platform, constituting a three-point kinematic support system.

  6. Low Cost, Upper Stage-Class Propulsion

    Science.gov (United States)

    Vickers, John

    2015-01-01

    The low cost, upper stage-class propulsion (LCUSP) element will develop a high strength copper alloy additive manufacturing (AM) process as well as critical components for an upper stage-class propulsion system that will be demonstrated with testing. As manufacturing technologies have matured, it now appears possible to build all the major components and subsystems of an upper stage-class rocket engine for substantially less money and much faster than traditionally done. However, several enabling technologies must be developed before that can happen. This activity will address these technologies and demonstrate the concept by designing, manufacturing, and testing the critical components of a rocket engine. The processes developed and materials' property data will be transitioned to industry upon completion of the activity. Technologies to enable the concept are AM copper alloy process development, AM post-processing finishing to minimize surface roughness, AM material deposition on existing copper alloy substrate, and materials characterization.

  7. Mars Ascent Vehicle-First Stage Motor

    Science.gov (United States)

    Dankanich, John; Doudrick, Scott; Williams, Jacob

    2015-01-01

    This project is development effort of a first stage solid motor based on a two-stage solid motor Mars Ascent Vehicle (MAV) design for the robotic Mars Sample Return (MSR) mission (fig. 1). The MSR MAV has been studied for decades and multiple concepts have been shown to meet the mission objectives as posed.1 However, there remains significant uncertainty with the MAV requirements. The sample container and sample cache itself is immature. Additionally, MAV-specific requirements ranging from full three-axis controlled and strict communication requirements to minimal capability concepts are still under consideration. Given the maturity of the overall mission requirements, the MAV has been limited to a large number of parametric analyses and paper studies. Recently, a Jet Propulsion Laboratory study highlighted the flexibility of a two-stage solid motor concept. The MAV itself is driven by the constraints of the Entry, Decent, and Landing (EDL) system. Within the EDL constraints, there is a range of MAV options ranging in complexity from simple spun upper stage options to higher capability three-axis controlled solutions. There are also options to trade the ratio of mission (Delta)V between the first and second stage. Finally, sensitivity studies also indicated that solid motors with a high percentage of off-load flexability only had minor impact on the total system mass over a single point design optimized motor. This flexibility in the first stage motor has allowed NASA to mature the design of the motor beyond parametric analyses and start to address known design challenges of the motor.

  8. The thesis of stages fourteen years later

    Science.gov (United States)

    Beeby, C. E.

    1980-12-01

    The author indicates the changes and additions he would make to his book ` The Quality of Education in Developing Countries' (1966) if he were re-writing it in 1980. He would make clearer that his primary interest is in a continuum of change, the process of growth of a school system, and that the `stages' are only a convenient non-mathematical artifact to make the thesis more useful to administrators and planners. In the light of more recent developments and experiences, he now gives new stress to the pluralism of objectives at the stage of Meaning, and discusses the political, social, cultural and financial reasons why a country may choose not to take the difficult step from stage III to stage IV. Recent forms of alternative education, particularly those embodying plans for lifelong education, offer some hope of bypassing his thesis of stages. More consideration is given to constraints other than that of teacher qualification, though the difficulty of changing the skills, habits, attitudes and purposes in the teaching profession remain the chief obstacle to qualitative growth. Particular attention is paid to `crash' programmes where processes that are, by their very nature, successive are compressed into simultaneous or almost simultaneous ones. Some implications of the thesis of stages for teacher training are briefly dealt with. Regarding the application of the thesis to secondary education, he maintains that a better model of growth would be one based on the capacity of secondary education to respond to the changing economic and social demands of the community. Finally, he suggests three methods of testing his hypotheses and pleads that more consideration be given to building up a body of educational, theory based on the experience of developing countries over the past three decades.

  9. The Lower Depths on the German Stage

    Directory of Open Access Journals (Sweden)

    Svetlana M. Demkina

    2018-03-01

    Full Text Available This article examines the stage history of M. Gorky’s play The Lower Depths in Germany. The author discusses German stage history of Gorky’s work against the social background and in the context of major artistic tendencies of the 20 th century. Steady interest in Gorky as a playwright in Germany is due to the acute social importance and universality of the problems reflected in his dramas. Bearing on the archive materials of the Gorky Museum, the essay explores interpretations of Gorky’s cult drama The Lower Depths in the work of European stage directors, acclaimed reformers of theatrical art. A significant part of the “Gorky and German Theater” section of the Gorky Museum (IWL RAS is devoted to The Lower Depths. Two series of photographs represent the first German staging of Nachtasyl (German translation of The Lower Depths. The performance of Max Reinhardt and Richard Vallentin in Berlin Kleines Theater on January 10–23, 1903, had great success and good takings. After the premiere, attention to the personality of Gorky in Europe increased; he became the most popular Sovietauthor. When Nazi came to power, they banned Gorky’s work in Germany: he reappeared on the German stage only after the World War II. In the late 1960s, on the wave of Gorky’s centenary (1968, world theatres ran a series of performances based on his plays. The 1970s were marked by a renewal of interest to Gorky the playwright. The Lower Depths was staged in Europe, the USA, and the UK. Both directors and critics perceived Gorky’s dramaturgy in the context of works of his contemporaries — Shaw, Ibsen, Hauptmann, Tolstoy, Chekhov.

  10. Pelvic irradiation for stage II ovarian carcinoma

    International Nuclear Information System (INIS)

    Terada, K.Y.; Morley, G.W.; Roberts, J.A.

    1988-01-01

    Over a 20-year period, 34 patients with FIGO stage II ovarian carcinoma were treated with postoperative pelvic irradiation at the University of Michigan. Complications of radiation treatment were minimal. The overall actuarial disease-free 5-year survival was 53%. This was not significantly different for substages IIA, IIB, or IIC. Patients with well-differentiated tumors had a significantly better survival than patients with moderate or poorly differentiated tumors (P less than 0.05). The implications for managing stage II ovarian carcinoma are discussed

  11. Clinical presentation and staging of Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Gallamini, Andrea; Hutchings, Martin; Ramadan, Safaa

    2016-01-01

    In the present chapter the authors present a brief overview of the diagnostic methods proposed over time for Hodgkin lymphoma (HL) spread detection, moving from surgical procedures, through standard radiological and functional imaging techniques to the present state of the art for HL staging....... The main body of the review will be dedicated to the recently published guidelines for lymphoma staging (including HL) agreed by the experts during the 12th International Congress for Malignant Lymphoma in Lugano. The recommendations of the panel on how to integrate flurodeoxyglucose positron emission...

  12. RESIDUAL RISK ASSESSMENT: GAS DISTRIBUTION STAGE ...

    Science.gov (United States)

    This document describes the residual risk assessment for the Gas Distribution Stage 1 souce category. For stationary sources, section 112 (f) of the Clean Air Act requires EPA to assess risks to human health and the environment following implementation of technology-based control standards. If these technology-based control standards do not provide an ample margin of safety, then EPA is required to promulgate addtional standards. This document describes the methodology and results of the residual risk assessment performed for the Gas Distribution Stage 1 source category. The results of this analyiss will assist EPA in determining whether a residual risk rule for this source category is appropriate.

  13. Surveillance in stage I testicular cancer

    DEFF Research Database (Denmark)

    Daugaard, Gedske; Petersen, Peter Meidahl; Rørth, Mikael

    2003-01-01

    Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29%). In patie......Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29...

  14. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L; Carde, P; Mauch, P

    1992-01-01

    In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a global...... be reduced, and that the stress of experiencing a relapse is avoided in many patients. The major argument against the use of chemotherapy up front is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may...

  15. Architecture and Stages of the Experience City

    DEFF Research Database (Denmark)

    This book presents more than 41 articles on ‘Architecture and Stages of the Experience City'. The aim of the book is to investigate current challenges related to architecture, art and city life in the ‘Experience City' and it is presenting cutting edge knowledge and experiences within the following...... themes: Experience City Making Digital Architecture Stages in the Experience City The City as a Learning Lab Experience City Architecture Performative Architecture Art and Performance Urban Catalyst and Temporary Use...

  16. Surveillance for Stage I Nonseminoma Testicular Cancer

    DEFF Research Database (Denmark)

    Daugaard, Gedske; Gundgaard, Maria Gry; Mortensen, Mette Saksø

    2014-01-01

    PURPOSE: To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. PATIENTS AND METHODS: From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion....... Relapses after 5 years were seen in 0.5% of the whole cohort or in 1.6% of relapsing patients. The majority of relapses (94.4%) belonged to the good prognostic group according to the International Germ Cell Cancer Collaborative Group classification. The disease-specific survival at 15 years was 99...

  17. [Treatment of early stage Hodgkin disease

    DEFF Research Database (Denmark)

    Specht, Lena; Carde, P.; Mauch, P.

    1993-01-01

    In early stage Hodgkin's disease the optimal choice of treatment is still an unresolved issue. Twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out world-wide. The preliminary results of a global meta-analysis of these trials...... a relapse is avoided in many patients. The major argument against early chemotherapy is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may be kept at a minimum. Recently, trials have been carried out...

  18. Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer

    Science.gov (United States)

    2017-04-12

    Ovarian Sarcoma; Ovarian Stromal Cancer; Stage I Uterine Sarcoma; Stage I Vaginal Cancer; Stage I Vulvar Cancer; Stage IA Cervical Cancer; Stage IA Endometrial Carcinoma; Stage IA Fallopian Tube Cancer; Stage IA Ovarian Epithelial Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IA Primary Peritoneal Cavity Cancer; Stage IB Cervical Cancer; Stage IB Endometrial Carcinoma; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Epithelial Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IB Primary Peritoneal Cavity Cancer; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Epithelial Cancer; Stage IC Ovarian Germ Cell Tumor; Stage IC Primary Peritoneal Cavity Cancer; Stage II Endometrial Carcinoma; Stage II Gestational Trophoblastic Tumor; Stage II Uterine Sarcoma; Stage II Vaginal Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Primary Peritoneal Cavity Cancer; Stage IIB Cervical Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Primary Peritoneal Cavity Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Primary Peritoneal Cavity Cancer; Stage III Gestational Trophoblastic Tumor; Stage III Uterine Sarcoma; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Cervical Cancer; Stage IIIA Endometrial Carcinoma; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Cervical Cancer; Stage IIIB Endometrial Carcinoma; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Endometrial Carcinoma; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell

  19. Staging in Patients with Small-Cell Lung Carcinoma; PET-CT versus Standard Staging Procedures

    Directory of Open Access Journals (Sweden)

    Burcu Yalçın

    2016-12-01

    Full Text Available Objective: The most important factor for accurate treatment of patients with small cell lung carcinoma (SCLC is accuracy of the initial staging. The aim of this study was to determine how often patients, staged as local or local-advanced disease by standard staging procedures (SSPs, would be staged to have a metastatic disease based on the findings of the positron emission tomography–computed tomography (PET-CT scan. Methods: Patients with SCLC who were staged as I, II, or III disease by SSPs (according to the American Joint Committee on Cancer Staging, 7th edition formed the study population. SSPs included computed tomography of chest, abdomen, brain (or magnetic resonance imaging of brain, and bone scintigraphy. These patients were re-staged with 18F-FDG PET-CT scan. Results: Between 2013 and 2015, 27 patients were prospectively studied. Of these patients, 92.5% were male and the median age was 61. Among 27 patients, distant metastasis was detected by PET-CT in 7 (25.9% patients. Two of 7 patients were determined as stage IIIA by SSPs and 5 of 17 patients that were determined as stage IIIB by SSPs were upstaged to metastatic disease by PET-CT. All of the 7 patients had bone metastasis by PET-CT. But bone metastasis could not be detected with bone scintigraphy. Conclusion: PET-CT detected distant metastasis in one quarter of SCLC stage III patients by SSPs. Patients who staged local-advanced SCLC with CT of the chest have to be assessed by PET-CT for extracranial distant metastasis.

  20. Sleep Stage Transition Dynamics Reveal Specific Stage 2 Vulnerability in Insomnia

    NARCIS (Netherlands)

    Wei, Yishul; Colombo, Michele A; Ramautar, Jennifer R; Blanken, Tessa F; van der Werf, Ysbrand D; Spiegelhalder, Kai; Feige, Bernd; Riemann, Dieter; Van Someren, Eus J W

    2017-01-01

    Study Objectives: Objective sleep impairments in insomnia disorder (ID) are insufficiently understood. The present study evaluated whether whole-night sleep stage dynamics derived from polysomnography (PSG) differ between people with ID and matched controls and whether sleep stage dynamic features

  1. Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma

    NARCIS (Netherlands)

    Jobsen, J.J.; Schutter, E.M.J.; Meerwaldt, J.H.; van der Palen, Jacobus Adrianus Maria; van der Sijde, R.; Naudin ten Cate, L.

    2001-01-01

    The aim of this study is to report survival and results of therapy and possible prognostic factors in women with pathologic stage II endometrial carcinoma. Forty-two patients with pathologic stage II endometrial carcinoma were treated at the department of Radiation Oncology of the Medisch Spectrum

  2. Pressure-induced staging transitions and stage disorder in dilute potassium-graphite intercalation compounds

    International Nuclear Information System (INIS)

    Fischer, J.E.; Kim, H.J.

    1987-01-01

    We extend our previous study of high-pressure staging transitions and stage disorder to dilute potassium-graphite intercalation compounds, using the Hendricks-Teller analysis of elastic neutron scattering (00L) profiles measured at 300 K over a broad q range. The dilute regime begins at a concentration [K]/[C]approx. <1/33, all samples in this regime behaving qualitatively the same at high pressure. A continuous transition starts immediately near P = 0, leading to a well-ordered higher stage with no apparent connection to in-plane density or structure. This is stable only over a small range, transforming abruptly at slightly higher P to a still higher stage or stage mixture, the index of which is consistent with the specific in-plane density imposed by commensurate 2 x 2 lockin. Disorder generally increases with average stage index (i.e., with increasing P or decreasing [K]/[C] ratio), consistent with the theory of Kirczenow. Disorder in the most dilute samples is better represented by a skewed distribution of many stage packages than by a random mixture of two or three different stage cells

  3. Comparison between a two-stage and single-stage digesters when ...

    African Journals Online (AJOL)

    Phenol is a pollutant found in many industrial wastewaters, which diminishes biogas formation in anaerobic digesters. In this study, a two-stage (acidogenic and methanogenic) anaerobic digester (TSAD) was compared to a single stage digester (SSD), in treating a synthetic wastewater contaminated with phenol.

  4. Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer

    Science.gov (United States)

    2017-12-05

    Ductal Breast Carcinoma In Situ; Invasive Breast Carcinoma; Stage 0 Breast Cancer; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer

  5. Behaviorism and the Stages of Scientific Activity

    Science.gov (United States)

    Moore, J.

    2010-01-01

    Following from an earlier analysis by B. F. Skinner, the present article suggests that the verbal processes in science may usefully be viewed as following a three-stage progression. This progression starts with (a) identification of basic data, then moves to (b) description of relations among those data, and ultimately concludes with (c) the…

  6. Two stage-type railgun accelerator

    International Nuclear Information System (INIS)

    Ogino, Mutsuo; Azuma, Kingo.

    1995-01-01

    The present invention provides a two stage-type railgun accelerator capable of spiking a flying body (ice pellet) formed by solidifying a gaseous hydrogen isotope as a fuel to a thermonuclear reactor at a higher speed into a central portion of plasmas. Namely, the two stage-type railgun accelerator accelerates the flying body spiked from a initial stage accelerator to a portion between rails by Lorentz force generated when electric current is supplied to the two rails by way of a plasma armature. In this case, two sets of solenoids are disposed for compressing the plasma armature in the longitudinal direction of the rails. The first and the second sets of solenoid coils are previously supplied with electric current. After passing of the flying body, the armature formed into plasmas by a gas laser disposed at the back of the flying body is compressed in the longitudinal direction of the rails by a magnetic force of the first and the second sets of solenoid coils to increase the plasma density. A current density is also increased simultaneously. Then, the first solenoid coil current is turned OFF to accelerate the flying body in two stages by the compressed plasma armature. (I.S.)

  7. [Second stage of labor: Does accelerations matter?].

    Science.gov (United States)

    Martí-Gamboa, S; Rodríguez-Lázaro, L; Redrado-Giménez, O; Ruiz-Sada, J; Castón-Mateo, S

    2016-05-01

    Accelerations role during the second stage of labor has not been studied and current classification system NICHD downplays its presence. The objective of this study is to determine validity for acidemia detection of the loss of accelerations during the second stage of labor. This is a one year retrospective case-control study of 102 neonates with acidemia defined as an umbilical cord gas pH≤7.10 compared to 100 non acidemic controls. The last thirty minutes of CTG were evaluated by two obstetricians blind to clinical and outcome data that classified tracings into categories according to NICHD definitions, determining the presence or absence of accelerations. Validity of NICHD categories and absence of accelerations were calculated. 85% of fetuses presented a category II tracing in the last 30 minutes of labor. Absence of accelerations was associated with neonatal acidemia (ORa 4.43). Category II tracings were not associated with acidemia after adjusting for confounding factors.Validity of the absence of accelerations during the second stage of labor was higher in terms of sensitivity (80.3%), specificity (54%) and global value (67%) to that of the presence of a category II tracing (96%, 24% and 60% respectively) in this period. The absence of accelerations during the second stage of labor shows a bigger validity for neonatal acidemia than the presence of a category II tracing.

  8. Erikson Psychosocial Stage Inventory: A Factor Analysis

    Science.gov (United States)

    Gray, Mary McPhail; And Others

    1986-01-01

    The 72-item Erikson Psychosocial Stage Inventory (EPSI) was factor analyzed for a group of 534 university freshmen and sophomore students. Seven factors emerged, which were labeled Initiative, Industry, Identity, Friendship, Dating, Goal Clarity, and Self-Confidence. Item's representing Erikson's factors, Trust and Autonomy, were dispersed across…

  9. Capacitor blocks for linear transformer driver stages.

    Science.gov (United States)

    Kovalchuk, B M; Kharlov, A V; Kumpyak, E V; Smorudov, G V; Zherlitsyn, A A

    2014-01-01

    In the Linear Transformer Driver (LTD) technology, the low inductance energy storage components and switches are directly incorporated into the individual cavities (named stages) to generate a fast output voltage pulse, which is added along a vacuum coaxial line like in an inductive voltage adder. LTD stages with air insulation were recently developed, where air is used both as insulation in a primary side of the stages and as working gas in the LTD spark gap switches. A custom designed unit, referred to as a capacitor block, was developed for use as a main structural element of the transformer stages. The capacitor block incorporates two capacitors GA 35426 (40 nF, 100 kV) and multichannel multigap gas switch. Several modifications of the capacitor blocks were developed and tested on the life time and self breakdown probability. Blocks were tested both as separate units and in an assembly of capacitive module, consisting of five capacitor blocks. This paper presents detailed design of capacitor blocks, description of operation regimes, numerical simulation of electric field in the switches, and test results.

  10. Staging "Swissness": Inter- and Intracultural Theatre Translation

    Science.gov (United States)

    Wilkinson, Jane

    2005-01-01

    This paper examines the choice to translate plays from "Hochdeutsch" (the standard form of the German language) into local dialect in German-speaking Switzerland. It first looks at the creative process of translating for the amateur stage and then at the reasons behind the choice to translate. It argues that this choice reflects a desire…

  11. Laparoscopic ultrasonography for abdominal tumor staging

    NARCIS (Netherlands)

    van Delden, O. M.; de Wit, L. T.; Nieveen van Dijkum, E. J.; Reeders, J. W.; Gouma, D. J.

    1998-01-01

    In recent years, laparoscopic ultrasonography has been introduced as an adjunct to diagnostic laparoscopy for staging of tumors of the upper gastrointestinal tract, liver, biliary tree, and pancreas. It has proved feasible to visualize most anatomic structures in the upper abdomen consistently and

  12. Development Stages and Curriculum: A Japanese Perspective.

    Science.gov (United States)

    Abiko, Tadahiko

    2002-01-01

    Discusses contemporary psychologists' criticism of Jean Piaget's developmental theory; reviews research in brain science, psychology, history, and the experiences of teachers; proposes a new theory of developmental stages based on children's shifting interests; discuses implications of "shifting interest center theory" for school…

  13. Staging and treatment of ovarian carcinoma

    International Nuclear Information System (INIS)

    De Palo, G.; Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan

    1989-01-01

    The staging and treatment of ovarian cancer is reviewed with special attention to developments during the last decade. Pathways of spread, presurgical and surgical staging are described and discussed, as are the biologic characters of the different histologic subtypes. Principles of surgery, endoperitoneal and external radiotherapy, single-drug and multiple-drug systemic chemotherapy (therapeutic and adjuvant), intraperitoneal chemotherapy, second-line chemotherapy, hormone therapy and the use of biologic response modifiers are reported and discussed with background of recent clinical trials. It is concluded that considerable progress has been made concerning diagnosis, staging and treatment of ovarian cancer. The proportion of cases in advanced stages has thus decreased and the survival rate increased. However, it is also obvious that the long-term prognosis for patients with advanced disease has not significantly improved over the last 10 years, despite introduction of multiple-drug regimens with high initial response rates. Ovarian cancer remains the most important gynecologic cause of death in the Western countries. (orig.)

  14. Stage- vs. Channel-strip Metaphor

    DEFF Research Database (Denmark)

    Gelineck, Steven; Korsgaard, Dannie Michael; Büchert, Morten

    2015-01-01

    . They do this using (1) a small physical mixing controller and (2) using an iPad app, which implements a simple stage metaphor interface. We measure how accurately they are able to replicate mixes in terms of volume and panning and how fast they are at doing so. Results reveal that performance...

  15. Optimization, an Important Stage of Engineering Design

    Science.gov (United States)

    Kelley, Todd R.

    2010-01-01

    A number of leaders in technology education have indicated that a major difference between the technological design process and the engineering design process is analysis and optimization. The analysis stage of the engineering design process is when mathematical models and scientific principles are employed to help the designer predict design…

  16. Stage 2 tool user’s manual.

    Science.gov (United States)

    2017-08-01

    The purpose of the Permitted Overweight Truck Corridor Analysis Tool (referred to in this document as the Stage 2 Tool) is to evaluate existing or to create new proposed overweight (OW) truck corridors to estimate the permitted OW truck, pavement, br...

  17. Terminal-stage prognostic analysis in candidemia.

    Science.gov (United States)

    Takuma, Takahiro; Shoji, Hisashi; Niki, Yoshihito

    2015-05-01

    Candidemia has an extremely high mortality rate but is not always the direct cause of death. Therefore, determining the effect of candidemia on death is extremely difficult. We investigated prognostic factors in patients with culture-proven candidemia at 2 Japanese university teaching hospitals from April 2009 through May 2013. To examine the effects of comorbid conditions, the Charlson comorbidity index was determined, and patients were subjectively classified into 3 clinical prognostic stages (terminal [death expected within 1 month], semiterminal [death expected within 6 months], and nonterminal [expected to live more than 6 months]). The Cox proportional hazard model was used for univariate and multivariate analyses of factors possibly affecting survival. On univariate analysis, factors identified as associated with an increased mortality rate were: admission to an internal medicine department, Candida glabrata, immunosuppression, hypotension, hypoxemia, and a terminal prognostic stage. Factors associated with a decreased mortality rate were: serum albumin, endophthalmitis investigation, and nonterminal prognostic stage. The mortality rate was significantly related to the prognostic stage on multivariate analysis (P candidemia. More important than candidemia in causing the deaths of patients with candidemia were the patients' background and comorbidity status. Therefore, rigorous methods should be used when investigating causes of death in terminally ill patients with candidemia. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  18. Uprated OMS engine for upper stage propulsion

    Science.gov (United States)

    Boyd, William C.

    1986-01-01

    The results of a pre-development component demonstration program on the use of a gas generator-driven turbopump that increases the Space Shuttle's Orbital Maneuvering Engine (OME) operating pressure are given. Tests and analysis confirm the the capability of the concept to meet or exceed performance and life requirements. Storable propellant upper stage concepts are also discussed.

  19. Treatment Options by Stage (Merkel Cell Carcinoma)

    Science.gov (United States)

    ... tissue. Merkel cells are in the layer of basal cells at the deepest part of the epidermis and are connected to nerves. Merkel cell carcinoma tends to grow quickly and to metastasize (spread) at an early stage . It usually spreads first to nearby lymph nodes and then may spread to lymph nodes or ...

  20. Researching the life stages of medicines: Introduction

    NARCIS (Netherlands)

    van der Geest, S.; Chamberlain, K.

    2011-01-01

    This introduction presents the concept of ‘biography’ or ‘life stages’ of medicines as an ordering principle and analytical tool for the study of medicines as social, commercial and symbolic objects. The first stages, production and marketing, which have been largely neglected by social scientists,

  1. Staging of bronchogenic carcinoma by computerized tomography

    International Nuclear Information System (INIS)

    Sommer, B.; Bauer, W.M.; Rath, M.; Fenzl, G.; Stelter, W.J.; Lissner, J.

    1981-01-01

    It was possible to check the information obtained by CT scanning in 36 patients out of 49 who had been subjected to computerized tomography, in respect of the extension of the primary tumour (T stage), and in 25 patients in respect of the degree of mediastinal lymphatic node involvement (N stage). In all 49 patients, the presence of bronchogenic carcinoma had been safely established. In 97% of the cases, assessment of the extension of the primary tumour was found to be correct. Assessment of the N stage, however, is more problematic, since detection of mediastinal lymphatic nodes by computerized tomography does not necessarily tell us something about their metastatic involvement. If all recognizable lymphatic nodes are interpreted as potential metastases, we have no false negative but 61% false positive results because of the frequency of postinflammatory or anthracotic lymphatic nodes. In case of exclusive assessment of lymphatic node enlargement above 1 cm diameter, the rate of metastatic nodes increases considerably (83%). Computerized tomography is definitely superior to all roentgenological methods in assessing the stage of a bronchogenic carcinoma; hence, it could occupy a key position in determining the diagnostic and therapeutic approach in patients with this disease. (orig.) [de

  2. The developmental stages of Pseudodiaptomus hessei (Copepoda ...

    African Journals Online (AJOL)

    1988-06-15

    Jun 15, 1988 ... reared in the laboratory. These were correlated with animals collected in the field. Nauplii were measured from the anterior margin to the tip of the caudal region, excluding spines. Copepodids were measured from the anterior border to the end of the caudal rami. The upper size limit reported for each stage ...

  3. Optimization of multi-stage pyrolysis

    International Nuclear Information System (INIS)

    Oyedun, Adetoyese Olajire; Lam, Ka Leung; Gebreegziabher, Tesfaldet; Hui, Chi Wai

    2013-01-01

    Pyrolysis process is considered as a beneficial option in waste treatment largely due to the products generated and the energy recovery when compared to other methods. In the conventional pyrolysis process, heat is continually supplied to the reactor until the final pyrolysis temperature is attained. The reactor is then maintained isothermally at this temperature until the pyrolysis is completed. This technique does not take into consideration the mechanism of the pyrolysis which involves both exothermic and endothermic reaction and the opportunity of gaining some processing benefits is often ignored. Multi-stage pyrolysis which is an approach to carry out pyrolysis with multiple heating stages in order to gain certain processing benefits has been introduced in our earlier works. 22.5% energy reduction was achieved in our past work with a 100% increase in completion time. This work therefore proposes the optimization of the operating parameters in multi-stage pyrolysis in order to limit the increase in completion time and also reduces the overall energy. This innovative approach can achieve a range of 24.7%–37.9% reduction in energy usage with 37%–50% increase in completion time depending on the heating rate for each heating stages. This approach has also been used for charcoal production

  4. TREATMENT FOR STAGE I TESTICULAR SEMINOMA

    Directory of Open Access Journals (Sweden)

    E. A. Burova

    2014-07-01

    Full Text Available Overall survival is about 100% in patients with stage I germinogenic testicular tumors after orchifuniculectomy, which is achieved, by applying alternative adjuvant approaches. The use of approaches, such as a follow-up, chemo- and radiotherapy, may be recommended in seminoma. The paper shows the advantages and disadvantages of these methods.

  5. Space Launch System Upper Stage Technology Assessment

    Science.gov (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy

    2014-01-01

    The Space Launch System (SLS) is envisioned as a heavy-lift vehicle that will provide the foundation for future beyond low-Earth orbit (LEO) exploration missions. Previous studies have been performed to determine the optimal configuration for the SLS and the applicability of commercial off-the-shelf in-space stages for Earth departure. Currently NASA is analyzing the concept of a Dual Use Upper Stage (DUUS) that will provide LEO insertion and Earth departure burns. This paper will explore candidate in-space stages based on the DUUS design for a wide range of beyond LEO missions. Mission payloads will range from small robotic systems up to human systems with deep space habitats and landers. Mission destinations will include cislunar space, Mars, Jupiter, and Saturn. Given these wide-ranging mission objectives, a vehicle-sizing tool has been developed to determine the size of an Earth departure stage based on the mission objectives. The tool calculates masses for all the major subsystems of the vehicle including propellant loads, avionics, power, engines, main propulsion system components, tanks, pressurization system and gases, primary structural elements, and secondary structural elements. The tool uses an iterative sizing algorithm to determine the resulting mass of the stage. Any input into one of the subsystem sizing routines or the mission parameters can be treated as a parametric sweep or as a distribution for use in Monte Carlo analysis. Taking these factors together allows for multi-variable, coupled analysis runs. To increase confidence in the tool, the results have been verified against two point-of-departure designs of the DUUS. The tool has also been verified against Apollo moon mission elements and other manned space systems. This paper will focus on trading key propulsion technologies including chemical, Nuclear Thermal Propulsion (NTP), and Solar Electric Propulsion (SEP). All of the key performance inputs and relationships will be presented and

  6. Potential for opportunity recognition along the stages of entrepreneurship

    OpenAIRE

    Wasdani, Kishinchand; Mathew, Mary

    2014-01-01

    The study primarily verifies whether ORP differs in stages of entrepreneurship and aims at identifying factors that influence ORP in different stages of entrepreneurship. The stages of entrepreneurship include pre-stage (individuals planning to start ventures), early-stage (entrepreneurs with ventures less than 3 years old) and late-stage (entrepreneurs with ventures more than 3 years in existence). The factors that were studied include personal factors (cognitive style, self-efficacy and mot...

  7. Meta-analysis of Gaussian individual patient data: Two-stage or not two-stage?

    Science.gov (United States)

    Morris, Tim P; Fisher, David J; Kenward, Michael G; Carpenter, James R

    2018-04-30

    Quantitative evidence synthesis through meta-analysis is central to evidence-based medicine. For well-documented reasons, the meta-analysis of individual patient data is held in higher regard than aggregate data. With access to individual patient data, the analysis is not restricted to a "two-stage" approach (combining estimates and standard errors) but can estimate parameters of interest by fitting a single model to all of the data, a so-called "one-stage" analysis. There has been debate about the merits of one- and two-stage analysis. Arguments for one-stage analysis have typically noted that a wider range of models can be fitted and overall estimates may be more precise. The two-stage side has emphasised that the models that can be fitted in two stages are sufficient to answer the relevant questions, with less scope for mistakes because there are fewer modelling choices to be made in the two-stage approach. For Gaussian data, we consider the statistical arguments for flexibility and precision in small-sample settings. Regarding flexibility, several of the models that can be fitted only in one stage may not be of serious interest to most meta-analysis practitioners. Regarding precision, we consider fixed- and random-effects meta-analysis and see that, for a model making certain assumptions, the number of stages used to fit this model is irrelevant; the precision will be approximately equal. Meta-analysts should choose modelling assumptions carefully. Sometimes relevant models can only be fitted in one stage. Otherwise, meta-analysts are free to use whichever procedure is most convenient to fit the identified model. © 2018 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  8. Initial Staging of Hodgkin’s Disease

    Science.gov (United States)

    Chiaravalloti, Agostino; Danieli, Roberta; Caracciolo, Cristiana Ragano; Travascio, Laura; Cantonetti, Maria; Gallamini, Andrea; Guazzaroni, Manlio; Orlacchio, Antonio; Simonetti, Giovanni; Schillaci, Orazio

    2014-01-01

    Abstract The objective of this study was to compare the diagnostic accuracy of positron emission tomography/low-dose computed tomography (PET/ldCT) versus the same technique implemented by contrast-enhanced computed tomography (ceCT) in staging Hodgkin’s disease (HD). Forty patients (18 men and 22 women, mean age 30 ± 9.6) with biopsy-proven HD underwent a PET/ldCT study for initial staging including an unenhanced low-dose computed tomography for attenuation correction with positron emission tomography acquisition and a ceCT, performed at the end of the PET/ldCT scan, in the same exam session. A detailed datasheet was generated for illness locations for separate imaging modality comparison and then merged in order to compare the separate imaging method results (PET/ldCT and ceCT) versus merged results positron emission tomography/contrast-enhanced computed tomography (PET/ceCT). The nodal and extranodal lesions detected by each technique were then compared with follow-up data that served as the reference standard. No significant differences were found at staging between PET/ldCT and PET/ceCT in our series. One hundred and eighty four stations of nodal involvement have been found with no differences in both modalities. Extranodal involvement was identified in 26 sites by PET/ldCT and in 28 by PET/ceCT. We did not find significant differences concerning the stage (Ann Arbor). Our study shows a good concordance and conjunction between PET/ldCT and ceCT in both nodal and extranodal sites in the initial staging of HD, suggesting that PET/ldCT could suffice in most of these patients. PMID:25121354

  9. Worldwide Esophageal Cancer Collaboration: pathologic staging data.

    Science.gov (United States)

    Rice, T W; Chen, L-Q; Hofstetter, W L; Smithers, B M; Rusch, V W; Wijnhoven, B P L; Chen, K L; Davies, A R; D'Journo, X B; Kesler, K A; Luketich, J D; Ferguson, M K; Räsänen, J V; van Hillegersberg, R; Fang, W; Durand, L; Cecconello, I; Allum, W H; Cerfolio, R J; Pera, M; Griffin, S M; Burger, R; Liu, J-F; Allen, M S; Law, S; Watson, T J; Darling, G E; Scott, W J; Duranceau, A; Denlinger, C E; Schipper, P H; Lerut, T E M R; Orringer, M B; Ishwaran, H; Apperson-Hansen, C; DiPaola, L M; Semple, M E; Blackstone, E H

    2016-10-01

    We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 85 adenosquamous carcinoma, and 26 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (51%), little weight loss (1.8 kg), 0-2 ECOG performance status (83%), and a history of smoking (70%). Cancers were pT1 (24%), pT2 (15%), pT3 (50%), pN0 (52%), pM0 (93%), and pG2-G3 (78%); most involved distal esophagus (71%). Non-risk-adjusted survival for both squamous cell carcinoma and adenocarcinoma was monotonic and distinctive across pTNM. Survival was more distinctive for adenocarcinoma than squamous cell carcinoma when pT was ordered by pN. Survival for pTis-1 adenocarcinoma was better than for squamous cell carcinoma, although monotonic and distinctive for both. WECC pathologic staging data is improved over that of the 7th edition, with more patients studied and patient and cancer variables collected. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics, and should direct 9th edition data collection. However, the role of pure pathologic staging as the principal point of reference for esophageal cancer staging is waning. © 2016 International Society for Diseases of the Esophagus.

  10. Method and system for dual resolution translation stage

    Science.gov (United States)

    Halpin, John Michael

    2014-04-22

    A dual resolution translation stage includes a stage assembly operable to receive an optical element and a low resolution adjustment device mechanically coupled to the stage assembly. The dual resolution stage also includes an adjustable pivot block mechanically coupled to the stage assembly. The adjustable pivot block includes a pivot shaft. The dual resolution stage further includes a lever arm mechanically coupled to the adjustable pivot block. The lever arm is operable to pivot about the pivot shaft. The dual resolution stage additionally includes a high resolution adjustment device mechanically coupled to the lever arm and the stage assembly.

  11. A comparison of tumor motion characteristics between early stage and locally advanced stage lung cancers

    International Nuclear Information System (INIS)

    Yu, Z. Henry; Lin, Steven H.; Balter, Peter; Zhang Lifei; Dong Lei

    2012-01-01

    Purpose: With the increasing use of conformal radiation therapy methods for non-small cell lung cancer (NSCLC), it is necessary to accurately determine respiratory-induced tumor motion. The purpose of this study is to analyze and compare the motion characteristics of early and locally advanced stage NSCLC tumors in a large population and correlate tumor motion with position, volume, and diaphragm motion. Methods and materials: A total of 191 (94 early stage, 97 locally advanced) non-small cell lung tumors were analyzed for this study. Each patient received a four-dimensional CT scan prior to receiving radiation treatment. A soft-tissue-based rigid registration algorithm was used to track the tumor motion. Tumor volumes were determined based on the gross tumor volume delineated by physicians in the end of expiration phase. Tumor motion characteristics were correlated with their standardized tumor locations, lobe location, and clinical staging. Diaphragm motion was calculated by subtracting the diaphragm location between the expiration and the inspiration phases. Results: Median, max, and 95th percentile of tumor motion for early stage tumors were 5.9 mm, 31.0 mm, and 20.0 mm, which were 1.2 mm, 12 mm, and 7 mm more than those in locally advanced NSCLC, respectively. The range of motion at 95th percentile is more than 50% larger in early stage lung cancer group than in the locally advanced lung cancer group. Early stage tumors in the lower lobe showed the largest motion with a median motion of 9.2 mm, while upper/mid-lobe tumors exhibited a median motion of 3.3 mm. Tumor volumes were not correlated with motion. Conclusion: The range of tumor motion differs depending on tumor location and staging of NSCLC. Early stage tumors are more mobile than locally advanced stage NSCLC. These factors should be considered for general motion management strategies when 4D simulation is not performed on individual basis.

  12. The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

    DEFF Research Database (Denmark)

    Rudkjøbing, Vibeke B; Thomsen, Trine R; Alhede, Morten

    2011-01-01

    Patients suffering from cystic fibrosis (CF) develop chronic lung infections because of highly viscous mucus, where bacteria can form biofilms. In this study, we investigated the microorganisms present in the lungs of end-stage and non-end-stage patients using standard culturing techniques......RNA gene analysis (J Clin Microbiol 2011, 49: 4352). Conversely, the non-end-stage patients were found to harbor several species by culturing. PNA FISH confirmed heterogeneous microbiota and showed that the bacteria were located in monospecies aggregates with no apparent physical interaction between...

  13. A trial of the three-stage light-gas gun with a preheating stage

    Science.gov (United States)

    Kondo, K.; Hironaka, Y.; Ito, H.; Sugiura, H.; Ozaki, S.; Takeba, A.; Katayama, M.

    1996-05-01

    A three-stage light-gas gun having a preheating and filling stage of gas was designed and installed in order to independently regulate the initial energy of the light gas. Although the operation and the performance of gun become so complicated, the computer simulations for the gun indicate many advantages, e.g., a scale of the gun much decreases in comparison with a conventional two-stage light-gas gun at the same value of the maximum obtainable projectile velocity.

  14. Accuracy of preoperative CT T staging of renal cell carcinoma: which features predict advanced stage?

    International Nuclear Information System (INIS)

    Bradley, A.J.; MacDonald, L.; Whiteside, S.; Johnson, R.J.; Ramani, V.A.C.

    2015-01-01

    Aims: To characterise CT findings in renal cell carcinoma (RCC), and establish which features are associated with higher clinical T stage disease, and to evaluate patterns of discrepancy between radiological and pathological staging of RCC. Materials and methods: Preoperative CT studies of 92 patients with 94 pathologically proven RCCs were retrospectively reviewed. CT stage was compared with pathological stage using the American Joint Committee on Cancer (AJCC), 7 th edition (2010). The presence or absence of tumour necrosis, perinephric fat standing, thickening of Gerota's fascia, collateral vessels were noted, and correlated with pT stage. The sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) for predicting pT stage ≥pT3a were derived separately for different predictors using cross-tabulations. Results: Twenty-four lesions were pathological stage T1a, 21 were T1b, seven were T2a, 25 were T3a, 11 were T3b, four were T3c, and two were T4. There were no stage T2b. Sixty-three (67%) patients had necrosis, 27 (29%) thickening of Gerota's fascia (1 T1a), 25 had collateral vessels (0 T1a), 28 (30%) had fat stranding of <2 mm, 20 (21%) of 2–5mm and one (1%) of >5 mm. For pT stage ≥pT3a, the presence of perinephric fat stranding had a sensitivity, specificity, PPV and NPV of 74%, 65%, 63%, and 76%, respectively. Presence of tumour necrosis had a sensitivity, specificity, PPV, and NPV of 81%, 44%, 54%, and 72%, respectively. Thickening of Gerota's fascia had a sensitivity, specificity, PPV, and NPV of 52%, 90%, 81% and 70%, respectively; and enlarged collateral vessels had a sensitivity, specificity, PPV, and NPV value of 52%, 94%, 88%, and 71% respectively. Conclusion: The presence of perinephric stranding and tumour necrosis were not reliable signs for pT stage >T3a. Thickening of Gerota's fascia and the presence of collateral vessels in the peri- or paranephric fat had 90% and 94% specificity, with 82% and 88

  15. Detailed experimental results for laser acceleration staging

    Directory of Open Access Journals (Sweden)

    W. D. Kimura

    2001-10-01

    Full Text Available Detailed experimental results of staging two laser-driven, relativistic electron accelerators are presented. During the experiment called STELLA (staged electron laser acceleration, an inverse free-electron laser (IFEL is used to modulate the electron energy, thereby, causing ∼3 fs microbunches to form separated by the laser wavelength at 10.6 μm (equivalent to a 35 fs period. A second IFEL accelerates the electrons depending upon the phase of the microbunches entering the second IFEL with respect to the laser beam driving the second IFEL. The data presented includes electron energy spectra as a function of the phase delay and laser power driving the first IFEL. Also shown is a comparison with the computer model, which includes space charge and misalignment effects.

  16. Whole organism blood stage vaccines against malaria.

    Science.gov (United States)

    Stanisic, Danielle I; Good, Michael F

    2015-12-22

    Despite a century of research focused on the development and implementation of effective control strategies, infection with the malaria parasite continues to result in significant morbidity and mortality worldwide. An effective malaria vaccine is considered by many to be the definitive solution. Yet, after decades of research, we are still without a vaccine that is capable of inducing robust, long lasting protection in naturally exposed individuals. Extensive sub-unit vaccine development focused on the blood stage of the malaria parasite has thus far yielded disappointing results. There is now a renewed focus on whole parasite vaccine strategies, particularly as they may overcome some of the inherent weaknesses deemed to be associated with the sub-unit approach. This review discusses the whole parasite vaccine strategy focusing on the blood stage of the malaria parasite, with an emphasis on recent advances and challenges in the development of killed and live attenuated vaccines. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Bladder Involvement in Stage I Endometriosis.

    Science.gov (United States)

    Brady, Paula C; Missmer, Stacey A; Laufer, Marc R

    2017-08-01

    Endometriosis-the ectopic implantation of endometrial-like tissue-affects 10% of adolescent females and adults. Bladder involvement, causing dysuria and hematuria, occurs in a very small number of endometriosis patients. The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed stage I endometriosis. Postoperatively, she reported persistent dysuria and passage of tissue in her urine. Cystoscopy showed diffuse erythema; urine cytology revealed glandular and spindle cells suggestive of endometriosis. She was transitioned from oral contraceptives to an intranasal gonadotropin-releasing hormone agonist, with symptom resolution. Intravesicular endometriosis coinciding with stage I disease supports a mechanism of endometriosis dissemination other than direct bladder infiltration. Patients with endometriosis who complain of urinary symptoms warrant assessment, because intravesicular bladder involvement cannot be excluded using pelviscopy. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  18. Malignant lymphomas - survey, classification and staging

    International Nuclear Information System (INIS)

    Pfannmueller, E.

    1984-01-01

    Malignant lymphomas are lympho-proliferative diseases in which the well-defined clinical pattern of Hodgkin's disease is contrasted by the heterogeneous group of lymphomas of the non-Hodgkin type. A simplified form of the sub-classification of Hodgkin's disease suggested in 1966 by Lukes and Butler, has found world-wide recognition. However, no generally accepted classification scheme has been evolved so far for the histological classification of other lymphomas, and this leads to considerable difficulties when comparing the therapy results from different centres. Precise histological classification and accurate staging before onset of therapy enable well-defined pronoses and therapy planning in line with case requirements. Radiological methods (X-ray chest, sonography, computed tomography, lymphography, scintigraphy etc.) are important in diagnosis required for accurate staging. (orig.) [de

  19. Staging Lung Cancer: Current Controversies and Strategies

    Directory of Open Access Journals (Sweden)

    Riyad Karmy-Jones

    1997-01-01

    Full Text Available A consistent approach to staging is required for the rational management of lung cancer. This paper was prepared at the request of the Standards Committee of the Canadian Thoracic Society, and reviews and discusses the relative merits of the available methods of staging. Whichever methods are chosen by a particular institution, the following points must be stressed. No patient can be considered automatically "unresectable" when chest radiography and/ or computed tomography demonstrate adenopathy or only suggest local invasion. Clinical and/or radiographical evidence suggesting extensive local or metastatic disease should be evaluated as completely as possible before subjecting the patient to a possible "nontherapeutic" thoracotomy. Finally, in some cases thoracotomy is required to decide whether the lesion is "completely" resectable.

  20. Computerized tomography and staging of bladder tumors

    International Nuclear Information System (INIS)

    Wozniak, A.; Luongo, A.; Nogueira, A.

    1982-01-01

    Computed Tomography (CT) has been employed in 13 patients with bladder tumors; 8 of them subsequently underwent surgery. Concordance between CT and pathological staging ranged in 90% of accurate results. Our data are discussed and compared to those of other authors in the literature. Staging was carried out according to the International Union Against Cancer. CT proved to be very accurate in the assessment of local and regional spread of tumor, limphatic progression and early detection of ureteral obstruction, as well as diagnosis of distant metastasis in selected patients. In poor candidates for surgery CT provided invaluable data to be used for localizing fields of radiation therapy. CT is a very well tolerated procedure, it is therefore suitable in subsequent treatment control. (Author) [pt

  1. Early diagnosis of early stage lung cancer

    Directory of Open Access Journals (Sweden)

    Andrej Debeljak

    2005-11-01

    Full Text Available Background: For the detection of premalignant changes of bronchial mucosa and early stages of lung cancer frequent chest X-ray, spiral low dose computed tomography, fluorescence bronchoscopy, sputum cytology (also with automated systems with genetic and molecular changes in the sputum cells and bronchial mucosa were used. These screening methods of the high-risk groups for lung cancer achieved: earlier diagnosis of lung cancer in lower stage, higher operability, longer 5-year survival, but without mortality reduction.Conclusions: In the clinical practice we can examine higher risk groups for lung cancer in randomised control trials with multimodality approach: frequent chest low-dose fast spiral computed tomography, sputum cytology with genetic and molecular examinations and fluorescence bronchoscopy. Smoking cessation remains the best means to achieve mortality reduction from lung cancer.

  2. THE TWO STAGE CRYSTAL COLLIMATOR FOR RHIC

    International Nuclear Information System (INIS)

    FLILLER, R.P. III; DREES, A.; GASSNER, D.; HAMMONS, L.; MCINTYRE, G.; TRBOJEVIC, D.; BIRYUKOV, V.; CHESNOKOV, Y.; TEREKHOV, V.

    2001-01-01

    The use of a two stage crystal collimation system in the RHIC yellow ring is examined. The system includes a copper beam scraper and a bent silicon crystal. While scrapers were installed in both of the RHIC rings before the year 2000 run, the crystal is installed for the 2001 run in one ring only, forming a two stage collimation system there. We present simulations of the expected channeling through the bent silicon crystal for both protons and gold ions with various beam parameters. This gives a picture of the particle losses around the ring, and the expected channeling efficiency. These results are then used to optimize the beam parameters in the area of the crystal to obtain maximum channeling efficiency, minimize out-scattering in the secondary collimator, and reduce beam halo

  3. Dental Age Estimation (DAE): Data management for tooth development stages including the third molar. Appropriate censoring of Stage H, the final stage of tooth development.

    Science.gov (United States)

    Roberts, Graham J; McDonald, Fraser; Andiappan, Manoharan; Lucas, Victoria S

    2015-11-01

    The final stage of dental development of third molars is usually helpful to indicate whether or not a subject is aged over 18 years. A complexity is that the final stage of development is unlimited in its upper border. Investigators usually select an inappropriate upper age limit or censor point for this tooth development stage. The literature was searched for appropriate data sets for dental age estimation and those that provided the count (n), the mean (x¯), and the standard deviation (sd) for each of the tooth development stages. The Demirjian G and Demirjian H were used for this study. Upper and lower limits of the Stage G and Stage H data were calculated limiting the data to plus or minus three standard deviations from the mean. The upper border of Stage H was limited by appropriate censoring at the maximum value for Stage G. The maximum age at attainment from published data, for Stage H, ranged from 22.60 years to 34.50 years. These data were explored to demonstrate how censoring provides an estimate for the correct maximum age for the final stage of Stage H as 21.64 years for UK Caucasians. This study shows that confining the data array of individual tooth developments stages to ± 3sd provides a reliable and logical way of censoring the data for tooth development stages with a Normal distribution of data. For Stage H this is inappropriate as it is unbounded in its upper limit. The use of a censored data array for Stage H using Percentile values is appropriate. This increases the reliability of using third molar Stage H alone to determine whether or not an individual is over 18 years old. For Stage H, individual ancestral groups should be censored using the same technique. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  4. Worldwide Esophageal Cancer Collaboration: clinical staging data.

    Science.gov (United States)

    Rice, T W; Apperson-Hansen, C; DiPaola, L M; Semple, M E; Lerut, T E M R; Orringer, M B; Chen, L-Q; Hofstetter, W L; Smithers, B M; Rusch, V W; Wijnhoven, B P L; Chen, K N; Davies, A R; D'Journo, X B; Kesler, K A; Luketich, J D; Ferguson, M K; Räsänen, J V; van Hillegersberg, R; Fang, W; Durand, L; Allum, W H; Cecconello, I; Cerfolio, R J; Pera, M; Griffin, S M; Burger, R; Liu, J-F; Allen, M S; Law, S; Watson, T J; Darling, G E; Scott, W J; Duranceau, A; Denlinger, C E; Schipper, P H; Ishwaran, H; Blackstone, E H

    2016-10-01

    To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 22,123 clinically staged patients, 8,156 had squamous cell carcinoma, 13,814 adenocarcinoma, 116 adenosquamous carcinoma, and 37 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (18.5-25 mg/kg 2 , 47%), little weight loss (2.4 ± 7.8 kg), 0-1 ECOG performance status (67%), and history of smoking (67%). Cancers were cT1 (12%), cT2 (22%), cT3 (56%), cN0 (44%), cM0 (95%), and cG2-G3 (89%); most involved the distal esophagus (73%). Non-risk-adjusted survival for squamous cell carcinoma was not distinctive for early cT or cN; for adenocarcinoma, it was distinctive for early versus advanced cT and for cN0 versus cN+. Patients with early cancers had worse survival and those with advanced cancers better survival than expected from equivalent pathologic categories based on prior WECC pathologic data. Thus, clinical and pathologic categories do not share prognostic implications. This makes clinically based treatment decisions difficult and pre-treatment prognostication inaccurate. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient characteristics, cancer categories, and treatment characteristics and should direct 9th edition data collection. © 2016 International Society for Diseases of the Esophagus.

  5. Initial stages of solidification of eutectic alloys

    International Nuclear Information System (INIS)

    Lemaignan, Clement

    1980-01-01

    The study of the various initial stages of eutectic solidification - i.e. primary nucleation, eutectic structure formation and stable growth conditions - was undertaken with various techniques including low angle neutron diffusion, in-situ electron microscopy on solidifying alloys and classical metallography. The results obtained allow to discuss the effect of metastable states during primary nucleation, of surface dendrite during eutectic nucleation and also of the crystallographic anisotropy during growth. (author) [fr

  6. Ecology of Postlarval Stages of Chigger Mites.

    Science.gov (United States)

    1985-12-05

    overwintering in the deutonymphal stage is increased fecundity in the newly emerged adult females. This phenomenon has been observed in Spodoptera littoralis...1981. Ecology and evolution of physiological time in insects. Am. Nat. 117: 1-23. Wagner, T. L., H. Wu, P. J. H. Sharpe, R. M. Schoolfield, and R. N...evidence for the early evolution of E. alfreddugesi in tropical soils where 25 0 C is the prevailing soil temperature year round (Chap. 1, Fig. 13

  7. EVALUATION OF LIVER FAILURE STAGE IN CHILDREN

    Directory of Open Access Journals (Sweden)

    G. V. Volynets

    2013-01-01

    Full Text Available Aim: to develop a system of evaluation of liver failure stage in children based on the International classification of functioning, disability and health (ICF. Patients and methods: based on the retrospective analysis of 14 biochemical markers, characterizing hepatic role in proteins, lipids and carbohydrates metabolism, of 115 children without liver diseases, 15 children who died of liver failure and 220 patients with various hepatic disorders, being followed-up in the SCCH of RAMS, a score system of evaluation of liver failure stage in children as an additional diagnostic tool was developed. Each of the biochemical markers was assessed according to the 5-point rating scale in dependence of its changes intensity. Results: the sum of points was considered to be a criterion of liver failure stage. According to the ICF recommendations, decrease of points on 0–4% (54–56 points corresponds with absence of liver failure; 5–24% (43–53 points — as mild dysfunction, 25–49% (29–42 points — as moderate; 50-95% (3–28 points — as severe; and 96–100% (0-2 points — as absolute failure. Conclusions: score system of evaluation of liver failure stage can be applied at any step of diagnostics and treatment of children of any age, due to independence of the used markers from the age. It can be used in assessment of the severity of disorder in dynamics, in determination of the prognosis and as criterion of indications to liver transplantation, as well as during medico-social examination.

  8. Staged tendon grafts and soft tissue coverage

    Directory of Open Access Journals (Sweden)

    David Elliot

    2011-01-01

    Full Text Available The objective of the two-staged flexor tendon method is to improve the predictability of final results in difficult problems dealing with tendon reconstruction. This article reviews the evolution and benefits of this procedure. It also considers the use of the technique to help deal with problems requiring pulley and skin reconstruction simultaneously with re-constituting the flexor tendon system.

  9. Radiologic techniques in staging malignant lymphoma

    International Nuclear Information System (INIS)

    Strijk, S.P.

    1987-01-01

    The main subject of this thesis is the evaluation of radiologic techniques in staging patients with newly diagnosed and untreated malignant lymphoma, or restaging patients with recurrent disease after a period of complete remission. Lymphography and, more recently, CT are available to examine the infradiaphragmatic nodes. CT also offers the possibility to examine other organ systems in the abdomen, and to visualize more lymph-node regions than lymphography. In ch. 2 and 4 the diagnostic performance of CT and lymphography in HD and NHL respectively are discussed. Literature data are summarized, and own results are given. The main goal is to determine whether the two methods are overlapping, competitive or complementary, and to answer the question what would be required for optimal staging. Staging laparotomy showed the unreliability of non-invasive examination methods for determining the presence or absence of lymphoma in the spleen. In ch. 3 and 5 the results of CT-based estimations of size of the spleen in relation to its histologic state, in patients with HD and NHL respectively are presented. The chest can be examined for lymphoma by conventional radiography, conventional tomography or computed tomography (CT). In ch. 6 the literature is reviewed, and the results with our patients are presented. The diagnostic performance of each examination is evaluated, and the results are analysed to define the most desirable approach in the examination of the chest for staging purposes. In ch. 7 the uncommon radiologic observation of calcification in lymph nodes, afflicted with HD and NHL is described. The literature is reviewed, and the clinical significance is indicated. 180 refs.; 22 figs.; 24 tabs

  10. Two-stage Security Controls Selection

    OpenAIRE

    Yevseyeva, Iryna; Basto-Fernandes, V.; van Moorsel, Aad; Janicke, Helge; Emmerich, M. T. M.

    2016-01-01

    Open Access article To protect a system from potential cyber security breaches and attacks, one needs to select efficient security controls, taking into account technical and institutional goals and constraints, such as available budget, enterprise activity, internal and external environment. Here we model the security controls selection problem as a two-stage decision making: First, managers and information security officers define the size of security budget. Second, the budget is distri...

  11. Two-stage nonrecursive filter/decimator

    International Nuclear Information System (INIS)

    Yoder, J.R.; Richard, B.D.

    1980-08-01

    A two-stage digital filter/decimator has been designed and implemented to reduce the sampling rate associated with the long-term computer storage of certain digital waveforms. This report describes the design selection and implementation process and serves as documentation for the system actually installed. A filter design with finite-impulse response (nonrecursive) was chosen for implementation via direct convolution. A newly-developed system-test statistic validates the system under different computer-operating environments

  12. Suicide in the Early Stage of Schizophrenia

    OpenAIRE

    Ventriglio, Antonio; Gentile, Alessandro; Bonfitto, Iris; Stella, Eleonora; Mari, Massimo; Steardo, Luca; Bellomo, Antonello

    2016-01-01

    Suicide is a relevant leading cause of death among patients affected by schizophrenia. Even if suicidal ideation may be present in different stages of disease, some differences have been described between the risk of suicide in patients experiencing first episode of psychosis and those with long-term schizophrenia. It is particularly higher during the first year of illness and reaches a steady decline over the following years. Suicidal ideation and attempts may also be common among subjects w...

  13. Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery

    Science.gov (United States)

    2017-06-05

    Recurrent Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma

  14. Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners

    Science.gov (United States)

    2018-02-06

    Malignant Female Reproductive System Neoplasm; Malignant Hepatobiliary Neoplasm; Partner; Stage III Breast Cancer; Stage III Cervical Cancer; Stage III Colorectal Cancer; Stage III Lung Cancer; Stage III Prostate Cancer; Stage III Skin Melanoma; Stage III Uterine Corpus Cancer; Stage IIIA Breast Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colorectal Cancer; Stage IIIA Lung Carcinoma; Stage IIIA Skin Melanoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Breast Cancer; Stage IIIB Cervical Cancer; Stage IIIB Colorectal Cancer; Stage IIIB Lung Carcinoma; Stage IIIB Skin Melanoma; Stage IIIB Uterine Corpus Cancer; Stage IIIC Breast Cancer; Stage IIIC Colorectal Cancer; Stage IIIC Skin Melanoma; Stage IIIC Uterine Corpus Cancer; Stage IV Breast Cancer; Stage IV Cervical Cancer; Stage IV Colorectal Cancer; Stage IV Lung Cancer; Stage IV Prostate Cancer; Stage IV Skin Melanoma; Stage IV Uterine Corpus Cancer; Stage IVA Cervical Cancer; Stage IVA Colorectal Cancer; Stage IVA Uterine Corpus Cancer; Stage IVB Cervical Cancer; Stage IVB Colorectal Cancer; Stage IVB Uterine Corpus Cancer

  15. Mindfulness Meditation or Survivorship Education in Improving Behavioral Symptoms in Younger Stage 0-III Breast Cancer Survivors (Pathways to Wellness)

    Science.gov (United States)

    2018-02-15

    Cancer Survivor; Early-Stage Breast Carcinoma; Stage 0 Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  16. Staging of rectal cancer by transrectal US

    International Nuclear Information System (INIS)

    Choi, Bo Whan; Ryu, Sie Tae; Park, Ki Soon; Lee, Yul; Chung, Soo Young

    1994-01-01

    To evaluate the accuracy of preoperative staging of rectal cancer by transrectal US(7.5MHz linear array transducer), 17 cases with primary rectal cancer who were examined by transrectal US and histopathologically proven, were analyzed. We correlated the sonographic features of the depth of rectal wall invasion, perirectal fat infiltration and perirectal lymph node metastasis with histopathologic findings. The tumor staging was analyzed according to the TNM classification. The depth of rectal wall invasion was in accordance with histopathologic findings in 15 of 17 cases (accuracy:88.2%). The sensitivity and specificity of transrectal US in predicting perirectal lymph node metastasis were 20% and 75%, respectively (accuracy : 58.8%). The sensitivity and specificity in predicting perirectal fat infiltration were 92.9% and 100%, respectively (accuracy : 94%). Perirectal fat infiltration and depth of rectal wall invasion were preoperatively diagnosed with relatively high accuracy, while perirectal lymph node metastasis with low accuracy. In conclusion, transrectal US is a useful imaging modality for preoperative staging of rectal cancer

  17. Suicide in the Early Stage of Schizophrenia

    Science.gov (United States)

    Ventriglio, Antonio; Gentile, Alessandro; Bonfitto, Iris; Stella, Eleonora; Mari, Massimo; Steardo, Luca; Bellomo, Antonello

    2016-01-01

    Suicide is a relevant leading cause of death among patients affected by schizophrenia. Even if suicidal ideation may be present in different stages of disease, some differences have been described between the risk of suicide in patients experiencing first episode of psychosis and those with long-term schizophrenia. It is particularly higher during the first year of illness and reaches a steady decline over the following years. Suicidal ideation and attempts may also be common among subjects with subthreshold psychotic experiences. Factors associated with the risk of suicide in the early phase of schizophrenia are previous suicidal attempts and social aspects: the lack of social support and stable relationships, social drift after the first episode, and social impairment. Also, several psychotic symptoms (suspiciousness, paranoid delusions, mental disintegration and agitation, negative symptoms, depression and hopelessness, and command hallucinations) and substance abuse are associated with higher risk of suicide. It has been described that perfectionism and good levels of insight among individuals who have recently developed psychotic symptoms are significantly associated with higher numbers of suicidal attempts. Moreover, recent evidences show that prefrontal cortex-based circuit dysfunction may be related to suicide in the early stage of schizophrenia. This narrative review summarizes available evidences on suicide in the early stage of schizophrenia and deals with issues to be further studied and discussed. PMID:27445872

  18. Hepatocellular carcinoma: early-stage management challenges

    Directory of Open Access Journals (Sweden)

    Erstad DJ

    2017-06-01

    Full Text Available Derek J Erstad,1 Kenneth K Tanabe2–4 1Department of Surgery, Massachusetts General Hospital, 2Harvard Medical School, 3Division of Surgical Oncology, 4Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA Abstract: Hepatocellular carcinoma (HCC is a major cause of cancer death and is increasing in incidence. This review focuses on HCC surveillance and treatment of early-stage disease, which are essential to improving outcomes. Multiple societies have published HCC surveillance guidelines, but screening efforts have been limited by noncompliance and overall lack of testing for patients with undiagnosed chronic liver disease. Treatment of early-stage HCC has become increasingly complex due to expanding therapeutic options and better outcomes with established treatments. Surgical indications for HCC have broadened with improved preoperative liver testing, neoadjuvant therapy, portal vein embolization, and perioperative care. Advances in post-procedural monitoring have improved efficacies of transarterial chemoembolization and radiofrequency ablation, and novel therapies involving delivery of radiochemicals are being studied in small trials. Finally, advances in liver transplantation have allowed for expanded indications beyond Milan criteria with non-inferior outcomes. More clinical trials evaluating new therapies and multimodal regimens are necessary to help clinicians design better treatment algorithms and improve outcomes. Keywords: hepatocellular carcinoma, hepatitis, surveillance, Barcelona clinic liver cancer, staging, cirrhosis, hepatectomy, hepatic resection, locoregional therapy, radiofrequency ablation, transarterial chemoembolization, liver transplantation

  19. Cutaneous T-Cell Lymphoma Early Stage

    Directory of Open Access Journals (Sweden)

    Anna Vasku

    2010-01-01

    A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis were compared to 198 controls of similar age and sex distribution, without personal or family history of chronic skin diseases and without personal history of malignancy. The three selected polymorphisms in the promoter of MMP-2 gene (−1575G/A, −1306C/T, and −790T/G were determined using the PCR-based methodology with RFLP. In our cohort, the associated GGCCTT MMP-2 promoter genotype was highly significantly more frequent in CTCL-Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.. To conclude, use of associated MMP-2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.

  20. Surgical treatment of advanced stage Freiberg disease

    Directory of Open Access Journals (Sweden)

    Emin Özkul

    2014-09-01

    Full Text Available Objective: Freiberg disesase is an avascular necrosis of the 2nd and 3rd metatarsal head and which kind of surgical option to be used is controversial in symptomatic patients. In this study the results of the advanced stage Freiberg’s disease patients, who were treated with surgery were evaluated. Methods: 12 patients (8 female, 4 male whose pain could not be solved with conservative method and underwent surgery (6 debridement, 3 osteotomy, 3 excision of the metatarsal head were included in this study. Themean age of the patients 19.1 (range 13- 31 and the mean follow-up 30.8(range 25-94 months. According to the Smillie classification 3 patients had type 5, 8 patients had type 4 and 1 patient had type 3 osteonecrosis. The results of the patients were evaluated according to Lesser Metatarsophalangeal-Interphalangeal Scale. Results: According to Lesser MetatarsophalangealInterphalangeal Scale 3 patients (%25 had excellent, 6 patients (%50 had good and 3 patients had poor results were obtained. 2 of 3 patients with poor results were type 5, and 1 patient was type 4 and all three patients underwent joint debridement. Conclusion:The method of surgical treatment of Freiberg disease determined according to the stage of the disease. Debridement alone in the treatment of patients with late stage is not enough, it should be combined with other methods.

  1. Prognostic factors in stage IB gastric cancer.

    Science.gov (United States)

    Aoyama, Toru; Yoshikawa, Takaki; Fujikawa, Hirohito; Hayashi, Tsutomu; Ogata, Takashi; Cho, Haruhiko; Yamada, Takanobu; Hasegawa, Shinichi; Tsuchida, Kazuhito; Yukawa, Norio; Oshima, Takashi; Oba, Mari S; Morita, Satoshi; Rino, Yasushi; Masuda, Munetaka

    2014-06-07

    To identify the subset of patients with stage IB gastric cancer with an unfavorable prognosis. Overall survival (OS) rates were examined in 103 patients with stage IB (T1N1M0 and T2N0M0) gastric cancer between January 2000 and December 2011. Univariate and multivariate analyses were performed to identify risk factors using a Cox proportional hazards model. The OS rates of patients with T1N1 and T2N0 cancer were 89.2% and 94.1% at 5-years, respectively. Both univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic factor. The OS rate was 81.8% at 5-years when the tumor was located in the upper third of the stomach and was 95.5% at 5-years when the tumor was located in the middle or lower third of the stomach (P = 0.0093). These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

  2. Indications for staging laparoscopy in pancreatic cancer

    Science.gov (United States)

    De Rosa, Antonella; Cameron, Iain C.; Gomez, Dhanwant

    2015-01-01

    Background To identify indications for staging laparoscopy (SL) in patients with resectable pancreatic cancer, and suggest a pre-operative algorithm for staging these patients. Methods Relevant articles were reviewed from the published literature using the Medline database. The search was performed using the keywords ‘pancreatic cancer’, ‘resectability’, ‘staging’, ‘laparoscopy’, and ‘Whipple's procedure’. Results Twenty four studies were identified which fulfilled the inclusion criteria. Of the published data, the most reliable surrogate markers for selecting patients for SL to predict unresectability in patients with CT defined resectable pancreatic cancer were CA 19.9 and tumour size. Although there are studies suggesting a role for tumour location, CEA levels, and clinical findings such as weight loss and jaundice, there is currently not enough evidence for these variables to predict resectability. Based on the current data, patients with a CT suggestive of resectable disease and (1) CA 19.9 ≥150 U/mL; or (2) tumour size >3 cm should be considered for SL. Conclusion The role of laparoscopy in the staging of pancreatic cancer patients remains controversial. Potential predictors of unresectability to select patients for SL include CA 19.9 levels and tumour size. PMID:26776846

  3. Suicide in the Early Stage of Schizophrenia.

    Science.gov (United States)

    Ventriglio, Antonio; Gentile, Alessandro; Bonfitto, Iris; Stella, Eleonora; Mari, Massimo; Steardo, Luca; Bellomo, Antonello

    2016-01-01

    Suicide is a relevant leading cause of death among patients affected by schizophrenia. Even if suicidal ideation may be present in different stages of disease, some differences have been described between the risk of suicide in patients experiencing first episode of psychosis and those with long-term schizophrenia. It is particularly higher during the first year of illness and reaches a steady decline over the following years. Suicidal ideation and attempts may also be common among subjects with subthreshold psychotic experiences. Factors associated with the risk of suicide in the early phase of schizophrenia are previous suicidal attempts and social aspects: the lack of social support and stable relationships, social drift after the first episode, and social impairment. Also, several psychotic symptoms (suspiciousness, paranoid delusions, mental disintegration and agitation, negative symptoms, depression and hopelessness, and command hallucinations) and substance abuse are associated with higher risk of suicide. It has been described that perfectionism and good levels of insight among individuals who have recently developed psychotic symptoms are significantly associated with higher numbers of suicidal attempts. Moreover, recent evidences show that prefrontal cortex-based circuit dysfunction may be related to suicide in the early stage of schizophrenia. This narrative review summarizes available evidences on suicide in the early stage of schizophrenia and deals with issues to be further studied and discussed.

  4. Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors

    Science.gov (United States)

    2017-09-12

    Cancer Survivor; No Evidence of Disease; Obesity; Overweight; Prostate Carcinoma; Sedentary Lifestyle; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage III Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  5. Collaboration with Pharma Will Introduce Nanotechnologies in Early Stage Drug Development | FNLCR Staging

    Science.gov (United States)

    The Frederick National Lab has begun to assist several major pharmaceutical companies in adopting nanotechnologies in early stage drug development, when the approach is most efficient and cost-effective. For some time, the national lab’s Nanotechno

  6. Treatment Options By Stage (Ovarian Germ Cell Tumors)

    Science.gov (United States)

    ... IIA, stage IIB, and stage IIC. Stage IIA : Cancer has spread to the uterus and/or fallopian tubes (the long slender tubes ... which eggs pass from the ovaries to the uterus). Stage IIB : Cancer has spread to other tissue within the pelvis . ...

  7. Hybrid staging of a Lysholm positive displacement engine with two Westinghouse two stage impulse Curtis turbines

    Energy Technology Data Exchange (ETDEWEB)

    Parker, D.A.

    1982-06-01

    The University of California at Berkeley has tested and modeled satisfactorly a hybrid staged Lysholm engine (positive displacement) with a two stage Curtis wheel turbine. The system operates in a stable manner over its operating range (0/1-3/1 water ratio, 120 psia input). Proposals are made for controlling interstage pressure with a partial admission turbine and volume expansion to control mass flow and pressure ratio for the Lysholm engine.

  8. [Comparison research on two-stage sequencing batch MBR and one-stage MBR].

    Science.gov (United States)

    Yuan, Xin-Yan; Shen, Heng-Gen; Sun, Lei; Wang, Lin; Li, Shi-Feng

    2011-01-01

    Aiming at resolving problems in MBR operation, like low nitrogen and phosphorous removal efficiency, severe membrane fouling and etc, comparison research on two-stage sequencing batch MBR (TSBMBR) and one-stage aerobic MBR has been done in this paper. The results indicated that TSBMBR owned advantages of SBR in removing nitrogen and phosphorous, which could make up the deficiency of traditional one-stage aerobic MBR in nitrogen and phosphorous removal. During steady operation period, effluent average NH4(+) -N, TN and TP concentration is 2.83, 12.20, 0.42 mg/L, which could reach domestic scenic environment use. From membrane fouling control point of view, TSBMBR has lower SMP in supernatant, specific trans-membrane flux deduction rate, membrane fouling resistant than one-stage aerobic MBR. The sedimentation and gel layer resistant of TSBMBR was only 6.5% and 33.12% of one-stage aerobic MBR. Besides high efficiency in removing nitrogen and phosphorous, TSBMBR could effectively reduce sedimentation and gel layer pollution on membrane surface. Comparing with one-stage MBR, TSBMBR could operate with higher trans-membrane flux, lower membrane fouling rate and better pollutants removal effects.

  9. A Novel Inflammation-Based Stage (I Stage in Patients with Resectable Esophageal Squamous Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Peng-Cheng Chen

    2016-01-01

    Full Text Available Background. Inflammation plays a key role in cancer. In the current study, we proposed a novel inflammation-based stage, named I stage, for patients with resectable esophageal squamous cell carcinoma (ESCC. Methods. Three hundred and twenty-three patients with resectable ESCC were enrolled in the current study. The I stage was calculated as follows: patients with high levels of C-reactive protein (CRP (>10 mg/L, neutrophil-to-lymphocyte ratio (NLR (>3.5, and platelet-count-to-lymphocyte ratio (PLR (>150 were defined as I3. Patients with two, one, or no abnormal value were defined as I2, I1, or I0, respectively. The prognostic factors were evaluated by univariate and multivariate analyses. Results. There were 112 patients for I0, 97 patients for I1, 66 patients for I2, and 48 patients for I3, respectively. The 5-year cancer-specific survival (CSS in patients with I0, I1, I2, and I3 was 50.0%, 30.9%, 18.2%, and 8.3%, respectively (I0 versus I1, P=0.002; I1 versus I2, P=0.012; I2 versus I3, P=0.020. Multivariate analyses revealed that I stage was an independent prognostic factor in patients with resectable ESCC (P<0.001. Conclusion. The inflammation-based stage (I stage is a novel and useful predictive factor for CSS in patients with resectable ESCC.

  10. Results of the Utah-Arizona stage-by-stage migrations

    Science.gov (United States)

    Ellis, D.H.; Mellon, C.; Kinloch, M.; Dolbeare, T.; Ossi, D.P.

    2001-01-01

    In an effort to find a safer means of teaching cranes new migration routes, each year (in 1998 and 1999) we transported a group of greater sandhill cranes (Grus canadensis tabida) stage-by-stage, in a horse trailer, with stops for brief flights at about 30-km intervals, along a 1300-1400-km fall migration route from Fish Springs National Wildlife Refuge (Fish Springs) in west-central Utah to the vicinity of Gila Bend, Arizona. Thereafter, we released them into a wild flock of sandhill cranes. All stage-by-stage birds were hand-reared with both a plastic crane decoy (to encourage them to roost in water) and a costume-draped humanoid form (called a scare-eagle and used for its namesake purpose). When these 2 teaching aids were placed in water, our cranes readily roosted nearby. All but 4 of our cranes proved cooperative (i.e., catchable at each of the ca 25-36 stops) during the migration. All were efficiently released into a wild flock and experienced good survival. The stage-by-stage method proved to be a safe means of transporting cranes south and giving them experience along the route. Some cranes apparently learned their route from the limited experience afforded by releasing them at intervals, and the 1999 cranes have made repealed migrations to or near our chosen northern terminus. However, after 1 winter in our chosen area, the birds have moved elsewhere to winter.

  11. Multi-stage fuel cell system method and apparatus

    Science.gov (United States)

    George, Thomas J.; Smith, William C.

    2000-01-01

    A high efficiency, multi-stage fuel cell system method and apparatus is provided. The fuel cell system is comprised of multiple fuel cell stages, whereby the temperatures of the fuel and oxidant gas streams and the percentage of fuel consumed in each stage are controlled to optimize fuel cell system efficiency. The stages are connected in a serial, flow-through arrangement such that the oxidant gas and fuel gas flowing through an upstream stage is conducted directly into the next adjacent downstream stage. The fuel cell stages are further arranged such that unspent fuel and oxidant laden gases too hot to continue within an upstream stage because of material constraints are conducted into a subsequent downstream stage which comprises a similar cell configuration, however, which is constructed from materials having a higher heat tolerance and designed to meet higher thermal demands. In addition, fuel is underutilized in each stage, resulting in a higher overall fuel cell system efficiency.

  12. Interconnected levels of multi-stage marketing: A triadic approach

    OpenAIRE

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. ...

  13. Two-stage dental implants inserted in a one-stage procedure : a prospective comparative clinical study

    NARCIS (Netherlands)

    Heijdenrijk, Kees

    2002-01-01

    The results of this study indicate that dental implants designed for a submerged implantation procedure can be used in a single-stage procedure and may be as predictable as one-stage implants. Although one-stage implant systems and two-stage.

  14. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer

    Science.gov (United States)

    2015-09-03

    Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-Negative Breast Carcinoma

  15. Port Pirie rare earths plant stage 3

    International Nuclear Information System (INIS)

    1990-08-01

    SX Holdings Limited intends to establish a rare earths plant at Port Pirie, South Australia. The proposal involves three stages of development, Stage 3 being to develop a monazite cracking plant and associated rare earths separation facility with the capacity to process up to 8,000 t/a of monazite-type ores. The proposed initial capacity is 4,000 t/a. This Draft Environmental Impact Statement relates to Stage 3 and is based on a monazite processing capacity of 8,000 t/a. The justification of the project is given in terms of use and the market for rare earths, the economic and environmental benefits of the proposal, the site selection process, site rehabilitation, and the consequences of not proceeding. A detailed description of the project is given, including the treatment process, site development and facilities, the supply of raw materials, product and waste handling, transport and storage, plant commissioning, operation and decommissioning, construction and staffing. The environmental issues entailed in the proposed development are discussed and include social effects, land use and infrasturcture considerations, risk management and transport. Occupational and environmental radiation issues, including assessments of exposure pathways and doses, management and monitoring, disposal of monosite residue are also discussed. It is estimated that the effects of disposal of 2,330 t/year of radioactive slurry in the sub-aerial tailing disposal system at Olympic Dam will be negligible. Moreover, the gamma dose increases would not result in any significant increase in occupational exposures. 38 refs., tabs., ills

  16. Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients

    Science.gov (United States)

    2017-09-05

    Stage IV Breast Cancer; Stage IV Pancreatic Cancer; Stage IV Colon Cancer; Stage IV Gastric Cancer; Stage IV Lung Cancer; Stage IV Liver Cancer; Malignant Hematologic Neoplasm; Biliary Cancer Metastatic; Pediatric Leukemia; Pediatric Lymphoma; Pediatric Brain Tumor; Pediatric Solid Tumor

  17. RESEARCH OF EARLY STAGES OF MODELING

    Directory of Open Access Journals (Sweden)

    Andrey Borisovich Nikolaev

    2017-05-01

    Full Text Available In represented article the questions of estimate of accuracy of an average integral characteristics of random process in the course of imitation modeling is considered. For the purposes of analytical treatment of initial stage of modeling a conditionally nonstationary Gaussian process is analyzed as stationary Gaussian process with boundary prehistory. A model of approximant autocorrelation function is recommended. Analytical expression for variance and mathematical expectation of average integral estimation are obtained. Statistical estimation efficiency criterion, the probability of belonging to correct parameter interval is introduced. Dependences of closeness in estimation statistics clearing interval at transient behavior are researched for various types of processes.

  18. Staging constructions of authenticity in organizational change

    DEFF Research Database (Denmark)

    Dupret, Katia

    2018-01-01

    that are emotionally charged. Through a socio-material perspective this paper seeks to explore how change processes in organizations challenges the idea of authentic leadership as a merely individual ability or personality trait and suggest that the authentic leader is distributed into the practices of change....... The paper explores how staged organizational change where authentic role-play and scripts from everyday life combined with meta-reflection and feedback construct new forms of reflection where its ethical side-effects should be discussed....

  19. The staging area concept for item control

    International Nuclear Information System (INIS)

    Williams, R.A.

    1984-01-01

    Accounting for special nuclear material contained in fabricated nuclear fuel rod items has been completely automated at the Westinghouse Nuclear Fuel Division facility in Columbia, South Carolina. Experience with the automated system has shown substantial difficulty in maintaining current knowledge of the precise locations of rods pulled out of the ''normal'' processing cycle. This has been resolved by creation of two tightly controlled staging areas for handling and distribution of all ''deviant'' rods by two specially trained expeditors. Thus, coupling automated data collection with centralized expert handling and distribution has created a viable system for control of large numbers of fuel rods in a major fabrication plant

  20. Breast cancer relapse stage I and II

    International Nuclear Information System (INIS)

    Perez Braojos, Ines; Diaz Gestoso, Yadira; Franco Odio, Sonia; Samuel Gonzalez, Victor

    2009-01-01

    Breast cancer has always been the most common malignancy in women and is the leading cause of death in women, study relapses Stages I and II therapeutic guidelines applied in the service Mastology the 1985 - 1989, was our first objective, the database used was Clinical history, which gave us all the material necessary, treatments were: In tumors up to 3 cm node-conserving surgery plus treatment N0 with ionizing radiation on the breast tangential C0G0 in tumors greater than 3 cm or less with N1 was modified radical mastectomy according to node status for the study of the part and the receiver adjuvant treatment conducted. (Author)

  1. Staging Events of Collaborative Design and Learning

    DEFF Research Database (Denmark)

    Binder, Thomas; Brandt, Eva; Horgen, Turid

    1998-01-01

    In this paper we will focus on events where collaborating parties get together to further the design work, and on how these events get staged in time and space. Our consern is the micro-organisation of time and space, which we find is poorly explored in the literature on product development. We...... open the paper by provisionally placing this concern within the debate on engineering design and product development. We argue that seeing the process of product development as a chain of events, each propelling the design work-and deliberately designing such events, with a clear focus on space, time...... for facilitating collaborative design....

  2. Stages in the energetics of baroclinic systems

    Science.gov (United States)

    Orlanski, Isidoro; Sheldon, John P.

    1995-10-01

    The results from several idealized and case studies are drawn together to form a comprehensive picture of "downstream baroclinic evolution" using local energetics. This new viewpoint offers a complementary alternative to the more conventional descriptions of cyclone development. These additional insights are made possible largely because the local energetics approach permits one to define an energy flux vector which accurately describes the direction of energy dispersion and quantifies the role of neighboring systems in local development. In this view, the development of a system's energetics is divided into three stages. In Stage 1, a pre-existing disturbance well upstream of an incipient trough loses energy via ageostrophic geopotential fluxes directed downstream through the intervening ridge, generating a new energy center there. In Stage 2, this new energy center grows vigorously, at first due to the convergence of these fluxes, and later by baroclinic conversion as well. As the center matures, it begins to export energy via geopotential fluxes to the eastern side of the trough, initiating yet another energy center. In Stage 3, this new energy center continues to grow while that on the western side of the trough decays due to a dwinding supply of energy via fluxes from the older upstream system and also as a consequence of its own export of energy downstream. As the eastern energy center matures, it exports energy further downstream, and the sequence begins anew. The USA "Blizzard of'93" is used as a new case study to test the limits to which this conceptual sequence might apply, as well as to augment the current limited set of case studies. It is shown that, despite the extraordinary magnitude of the event, the evolution of the trough associated with the Blizzard fits the conceptual picture of downstream baroclinic evolution quite well, with geopotential fluxes playing a critical rôle in three respects. First, fluxes from an old, decaying system in the

  3. A 2-MJ staged explosive generator

    Science.gov (United States)

    Chare, E. C.; Kaye, R. J.; Cowan, M.

    A self contained, three stage explosive generator is described. The system has produced 2 MJ of magnetic energy in a 40 nH load with a peak VI product of 0.2 TW. Current in the load rises from zero to peak value in 50 (SIGMA)s, the later part of the rise is approximately exponential with 10 (SIGMA)s e-fold time. Support equipment (power supply, initial energy capacitor bank, detonator firing units, delay generators, and Freon gas supply) can be protected from destructive effects of the explosive generators and reused.

  4. Stages in the economic globalization of tourism

    DEFF Research Database (Denmark)

    Hjalager, Anne Mette

    2007-01-01

    globalizing process. Outsourcing, transnational ownership structures and investments, cross-border marketing collaborations, the purchase and sale of knowhow, and the free movement of labor are developments not confined to manufacturing alone, but are also highly relevant for the modernization of tourism......There is more to the globalization of tourism than cross-border flows of customers and purchasing power. This paper distinguishes four stages and different manifestations of the globalization of the tourism industry, and shows that it, like many other business systems, is undergoing an irrevocable....... It and media logics are converging, and the scene is global. New policies that proactively include the potentials of its globalization are called for....

  5. Two-stage precipitation of cerium trifluoride

    International Nuclear Information System (INIS)

    Luerkens, D.W.

    1984-04-01

    Cerium was used as a surrogate for plutonium in studies of the solubility and precipitation of the trifluoride salt. Cerium trifluoride was precipitated using a two-stage precipitation system. A series of precipitation experiments were used to identify the significant process variables affecting precipitate characteristics. A mathematical precipitation model was developed which is based on the formation of cerium fluoride complexes. The precipitation model relates all process variables, in a single equation, to a single parameter which can be used to control particle characteristics. 11 references, 9 figures, 8 tables

  6. SEM hot stage sintering of UO2

    International Nuclear Information System (INIS)

    Miller, D.J.

    1976-06-01

    The sintering of hyperstoichiometric uranium dioxide powder compacts, in the hot stage of a scanning electron microscope, was continuously monitored using 16 mm time lapse movies. From alumina microspheres placed on the surface of the compacts, shrinkage measurements were obtained. Converting shrinkage measurements into densification profiles indicates that a maximum densification rate is reached at a critical density, independent of the constant heating rates. At temperatures above 1350 0 C, the movement of the reference microspheres made shrinkage measurements impossible. It is believed the evolution of UO 3 gas from hyperstoichiometric UO 2 is the cause of this limitation

  7. Un inventario de la catedral de Salamanca del siglo XIII

    Directory of Open Access Journals (Sweden)

    Ángel Riesco Terreros

    1996-01-01

    Full Text Available El inventario, objeto de este estudio, se conserva en el Archivo catedral de Salamanca con la signatura: ACS, cajón 44, legajo 2, número 26. Dicho inventario, el más antiguo que se conoce de la catedral e institución capitular salmantina, fue transliterado, sin resolver las abreviaturas y respetando los signos peculiares de la letra manuscrita, por don Manuel Gómez Moreno y Martínez y publicado por él mismo en la «Revista de Archivos, Bibliotecas y Museos», el año 1902, bajo el título: «Inventario de la Catedral de Salamanca, año 1275».

  8. Planck intermediate results: XIII. Constraints on peculiar velocities

    DEFF Research Database (Denmark)

    Cardoso, J.-F.; Delabrouille, J.; Ganga, K.

    2014-01-01

    Using Planck data combined with the Meta Catalogue of X-ray detected Clusters of galaxies (MCXC), we address the study of peculiar motions by searching for evidence of the kinetic Sunyaev-Zeldovich effect (kSZ). By implementing various filters designed to extract the kSZ generated at the positions...... of the clusters, we obtain consistent constraints on the radial peculiar velocity average, root mean square (rms), and local bulk flow amplitude at different depths. For the whole cluster sample of average redshift 0.18, the measured average radial peculiar velocity with respect to the cosmic microwave background...

  9. XIII symposium. Modern chemical physics. Theses of reports

    International Nuclear Information System (INIS)

    2001-01-01

    Materials of the thirteenth symposium on modern chemical physics are presented. They represent different directions of development of this field of knowledge, such as synthesis, structure, properties of metal-polymer compositions, radiation-chemical investigations in nanotechnology, problems of supercritical chemistry, calculations of kinetic parameters of catalytic systems [ru

  10. Volume XIII: The tertiary insects of North America

    Science.gov (United States)

    Scudder, Samuel H.

    1890-01-01

    That creatures so minute and fragile as insects, creatures which can so feebly withstand the changing seasons as to live, so to speak, but a moment, are to be found fossil, engraved, as it were, upon the rocks or embedded in their hard mass, will never cease to be a surprise to those unfamiliar with the fact. "So fragile," says Quinet, "so easy to crush, you would readily believe the insect one of the latest beings produced by nature, one of those which has least resisted the action of time; that its type, its genera, its forms, must have been ground to powder a thousand times, annihilated by the revolutions of the globe, and perpetually thrown into the crucible. For where is its defense? Of what value its antennae, its shield, its wings of gauze, against the commotions and the tempests which change the surface of the earth? When the mountains themselves are overthrown and the seas uplifted, when the giants of structure, the mighty quadrupeds, change form and habit under the pressure of circumstances, will the insect withstand them? Is it it which will display most character in nature? Yes! The universe flings itself against a gnat. Where will it find refuge? In its very diminutiveness, its nothingness."

  11. Defects and diffusion in semiconductors XIII an annual retrospective

    CERN Document Server

    Fisher, D J

    2011-01-01

    This thirteenth volume in the series covering the latest results in the field includes abstracts of papers which have appeared since the publication of Annual Retrospective XII (Volumes 303-304). As well as the over 300 semiconductor-related abstracts, the issue includes the original papers: ""Effect of KCl Addition upon the Photocatalytic Activity of Zinc Sulphide"" (D.Vaya, A.Jain, S.Lodha, V.K.Sharma, S.C.Ameta), ""Localized Vibrational Mode in Manganese-Doped Zinc Sulphide and Cadmium Sulphide Nanoparticles"" (M.Ragam, N.Sankar, K.Ramachandran), ""The Effect of a Light Impurity on the Elec

  12. Laser Beam Shaping XIII, Proceedings of SPIE Vol. 8490

    CSIR Research Space (South Africa)

    Forbes, A

    2012-09-01

    Full Text Available -ROM. Papers are published as they are submitted and meet publication criteria. A unique, consistent, permanent citation identifier (CID) number is assigned to each article at the time of the first publication. Utilization of CIDs allows articles to be fully... citable as soon as they are published online, and connects the same identifier to all online, print, and electronic versions of the publication. SPIE uses a six-digit CID article numbering system in which: ? The first four digits correspond to the SPIE...

  13. Progress report on nuclear data activities in India - XIII

    International Nuclear Information System (INIS)

    Balakrishnan, M.

    1978-01-01

    Activities in the field of nuclear data i.e. neutron cross sections and nuclear data related to reactors are reported. The work done during the calendar year 1977 in the Bhabha Atomic Research Centre, Bombay; Reactor Research Centre, Kalpakkam; The Tata Institute of Fundamental Research, Bombay; The Saha Institute of Nuclear Physics, Calcutta and the various Indian Universities and Post-Graduate Institute is covered. (M.G.B.)

  14. Changes of endocrine and ultrasound markers as ovarian aging in modifying the Stages of Reproductive Aging Workshop (STRAW) staging system with subclassification of mid reproductive age stage.

    Science.gov (United States)

    Ding, Ting; Luo, Aiyue; Jiang, Jingjing; Du, Xiaofang; Yang, Shuhong; Lai, Zhiwen; Shen, Wei; Lu, Yunping; Ma, Ding; Wang, Shixuan

    2013-01-01

    To demonstrate the changes of ovarian aging markers across the Stages of Reproductive Aging Workshop (STRAW) stages and modify it with subclassification of mid reproductive age stage (MR). Healthy females were classified according to the STRAW system. Serum basal FSH, LH, E2, and anti-Müllerian hormone (AMH) were detected, FSH/LH ratio calculated, and antral follicle counts (AFCs) determined in follicular phase. Progression through the whole STRAW stages under MR stage subdivided is associated with elevations in FSH, LH, FSH/LH ratio and decreases in E2, AMH and AFCs (p age in MR stage. 0.982 ng/ml AMH and 3 antral follicles (low level of MR 25-30 years) were set as cutoffs to distinguish MR stage into early mid reproductive age (EMR) and late mid reproductive age (LMR) stages. The women in EMR stage compared with LMR could retrieve more oocytes in IVF treatment (p stage, demonstrating disparate reproductive aging period with reduced ovarian reserve in young age across the STRAW stages.

  15. Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer

    Science.gov (United States)

    2017-12-28

    Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Stage I Ovarian Cancer; Stage IA Ovarian Cancer; Stage IB Ovarian Cancer; Stage IC Ovarian Cancer; Stage II Ovarian Cancer; Stage IIA Ovarian Cancer; Stage IIB Ovarian Cancer; Stage IIC Ovarian Cancer; Stage III Ovarian Cancer; Stage IIIA Ovarian Cancer; Stage IIIB Ovarian Cancer; Stage IIIC Ovarian Cancer; Stage IV Ovarian Cancer

  16. Ash related behaviour in staged and non-staged combustion of biomass fuels and fuel mixtures

    International Nuclear Information System (INIS)

    Becidan, Michaël; Todorovic, Dusan; Skreiberg, Øyvind; Khalil, Roger A.; Backman, Rainer; Goile, Franziska; Skreiberg, Alexandra; Jovovic, Aleksandar; Sørum, Lars

    2012-01-01

    The fate of selected elements (with focus on the important players in corrosion i.e. Na, K, Pb, Zn, Cl and S) are investigated for three biomasses (wood, demolition wood and coffee waste) and six mixtures of these as pellets both with and without air staging in a laboratory reactor. In order to get a complete overview of the combustion products, both online and offline analytical methods are used. Information is collected about: flue gas composition, particle (fly ash) size distribution and composition, bottom ash composition and melting properties. The main findings are: (1) complex interactions are taking place between the mixed fuels during combustion; (2) the mode of occurrence of an element as well as the overall structure of the fuel are important for speciation; (3) the pelletisation process, by bringing chemical elements into intimate contact, may affect partitioning and speciation; (4) staging and mixing might simultaneously have positive and negative effects on operation; (5) staging affects the governing mechanisms of fly ash (aerosols) formation. -- Highlights: ► Complex interactions are taking place between the mixed fuels during combustion. ► The mode of occurrence of an element as well as the overall structure of the fuel are important for speciation. ► The pelletisation process, by bringing chemical elements into intimate contact, may affect partitioning and speciation. ► Staging and mixing might simultaneously have positive and negative effects on operation. ► Staging affects the governing mechanisms of fly ash (aerosols) formation.

  17. The cost of unresectable stage III or stage IV melanoma in Italy

    Directory of Open Access Journals (Sweden)

    Maio Michele

    2012-11-01

    Full Text Available Abstract Background In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in the incidence of melanoma, with the highest rates reported in Scandinavia (15 cases per 100,000 inhabitants per year and the lowest in the Mediterranean countries (5 to 7 cases per 100,000 inhabitants per year. Methods The present article is based on the information collected in the MELODY study (MELanoma treatment patterns and Outcomes among patients with unresectable stage III or stage IV Disease: a retrospective longitudinal survey. In that study, the medical charts of patients were reviewed to document current treatment patterns and to analyse information on patients, disease characteristics and healthcare resource utilization related to the treatment of advanced melanoma regarding patients who presented with a diagnosis of malignant melanoma (stage I to IV at participating sites between 01 July, 2005 and 30 June, 2006. Results Summarizing, though the length of the follow-up period varies among sample patients, an amount of the yearly cost per patient can be estimated, dividing the average per patient total cost (€ 5.040 by the average follow-up duration (17.5 months and reporting to one year; on these grounds, unresectable stage III or stage IV melanoma in Italy would cost € 3,456 per patient per year.

  18. Assessment of skeletal maturation using mandibular second molar maturation stages.

    Science.gov (United States)

    Goyal, S; Goyal, S; Gugnani, N

    2014-01-01

    To investigate the relationship between cervical vertebrae maturation and mandibular second molar calcification stages. The study was designed as a retrospective, descriptive and crosssectional research project. Pre-treatment lateral cephalograms and panoramic radiographs of 99 males and 110 females in the age range of 7 to 18 years 7 months were evaluated with Demirjian Index (DI) and cervical vertebrae maturation indicators (CVMI) of Hassel and Farman. A null hypothesis was proposed that there is no relation between CVMI and DI. A highly significant association (Pearson's contingency coefficient 0.713 for males and 0.863 for females) was found between DI and CVMI. In males, the DI stage E corresponded to stage 2 of CVMI (pre-peak of pubertal growth spurt) and DI stages F and G corresponded to stages 3 and 4 of CVMI (peak of pubertal growth spurt). DI stage H was associated with stages 5 and 6 of CVMI (end of pubertal growth spurt). In females, the DI stages C, D corresponded to CVMI stages 1, 2; DI stages E, F with CVMI stages 3, 4; DI stages G, H with CVMI stages 5, 6. Mandibular second molar calcification stages can be used as indicators for assessment of skeletal maturity.

  19. Stage-specific predictive models for breast cancer survivability.

    Science.gov (United States)

    Kate, Rohit J; Nadig, Ramya

    2017-01-01

    Survivability rates vary widely among various stages of breast cancer. Although machine learning models built in past to predict breast cancer survivability were given stage as one of the features, they were not trained or evaluated separately for each stage. To investigate whether there are differences in performance of machine learning models trained and evaluated across different stages for predicting breast cancer survivability. Using three different machine learning methods we built models to predict breast cancer survivability separately for each stage and compared them with the traditional joint models built for all the stages. We also evaluated the models separately for each stage and together for all the stages. Our results show that the most suitable model to predict survivability for a specific stage is the model trained for that particular stage. In our experiments, using additional examples of other stages during training did not help, in fact, it made it worse in some cases. The most important features for predicting survivability were also found to be different for different stages. By evaluating the models separately on different stages we found that the performance widely varied across them. We also demonstrate that evaluating predictive models for survivability on all the stages together, as was done in the past, is misleading because it overestimates performance. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Oral cancer staging established by magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Rogério Ribeiro de Paiva

    2011-12-01

    Full Text Available The aim of this study was to compare clinical staging and magnetic resonance imaging (MRI staging for oral cancer, and to assess inter-observer agreement between oral and medical radiologists. A total of 10 patients diagnosed with oral cancer were assessed before treatment. A head and neck surgeon performed clinical TNM staging. Two medical radiologists and two oral radiologists performed a new staging assessment by interpreting MRI scans, without prior knowledge of the clinical staging. They evaluated the extent of the primary tumor (T, metastasis to regional lymph nodes (N and grouping by stages. The data were analyzed using the Kappa Index. There was significant agreement (p < 0.05 between the clinical and MRI staging assessments made by one oral radiologist for N stage, and between those made by one medical radiologist for the T and N stages and for the grouping by stages. In the MRI assessment, there was significant agreement among all four observers for both T stage and grouping by stages. For the N stage, there was no significant agreement between one oral radiologist and one medical radiologist or between both medical radiologists. There was significant agreement among the remaining radiologists. There was no agreement between the clinical and MRI staging. These results indicate the importance of using MRI for the diagnosis of oral cancer. Training initiatives and calibration of medical and oral radiologists should be promoted to provide an improved multidisciplinary approach to oral cancer.

  1. Reliability of cervical vertebral maturation staging.

    Science.gov (United States)

    Rainey, Billie-Jean; Burnside, Girvan; Harrison, Jayne E

    2016-07-01

    Growth and its prediction are important for the success of many orthodontic treatments. The aim of this study was to determine the reliability of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth. A group of 20 orthodontic clinicians, inexperienced in CVM staging, was trained to use the improved version of the CVM method for the assessment of mandibular growth with a teaching program. They independently assessed 72 consecutive lateral cephalograms, taken at Liverpool University Dental Hospital, on 2 occasions. The cephalograms were presented in 2 different random orders and interspersed with 11 additional images for standardization. The intraobserver and interobserver agreement values were evaluated using the weighted kappa statistic. The intraobserver and interobserver agreement values were substantial (weighted kappa, 0.6-0.8). The overall intraobserver agreement was 0.70 (SE, 0.01), with average agreement of 89%. The interobserver agreement values were 0.68 (SE, 0.03) for phase 1 and 0.66 (SE, 0.03) for phase 2, with average interobserver agreement of 88%. The intraobserver and interobserver agreement values of classifying the vertebral stages with the CVM method were substantial. These findings demonstrate that this method of CVM classification is reproducible and reliable. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  2. Visualizing the Early Stages of Phagocytosis.

    Science.gov (United States)

    Rashidfarrokhi, Ali; Richina, Veronica; Tafesse, Fikadu G

    2017-02-03

    The mammalian body is equipped with various layers of mechanisms that help to defend itself from pathogen invasions. Professional phagocytes of the immune system - such as neutrophils, dendritic cells, and macrophages - retain the innate ability to detect and clear such invading pathogens through phagocytosis 1 . Phagocytosis involves choreographed events of membrane reorganization and actin remodeling at the cell surface 2 , 3 . Phagocytes successfully internalize and eradicate foreign molecules only when all stages of phagocytosis are fulfilled. These steps include recognition and binding of the pathogen by pattern recognition receptors (PRRs) residing at the cell surface, formation of phagocytic cup through actin-enriched membranous protrusions (pseudopods) to surround the particulate, and scission of the phagosome followed by phagolysosome maturation that results in the killing of the pathogen 3 , 4 . Imaging and quantification of various stages of phagocytosis is instrumental for elucidating the molecular mechanisms of this cellular process. The present manuscript reports methods to study the different phases of phagocytosis. We describe a microscope-based approach to visualize and quantify the binding, phagocytic cup formation, and the internalization of particulate by phagocytes. As phagocytosis occurs when innate receptors on phagocytic cells encounter ligands on a target particle bigger than 0.5 µm, the assays we present here comprise the use of pathogenic fungi Candida albicans and other particulates such as zymosan and IgG-coated beads.

  3. Invasive cervical carcinoma (Stages IB-IIB)

    International Nuclear Information System (INIS)

    Sironi, S.; Zanello, A.; Rodighiero, M.G.; Vanzulli, A.; Del Maschio, A.; Taccagni, G.L.; Belloni, C.

    1991-01-01

    In the patients with invasive cervical carcinoma, the accurate assessment of parametrial invasion greatly affects the therapeutic choice between surgery and radiation therapy. As a matter of fact, surgery is usually performed only in the patients with carcinoma confined to the cervix, whereas those with parametrial involvement, or more advanced stages, are treated with radiation therapy. This prospective study was aimed at investigating the comparative adequecy of CT and MR imaging in assessing parametrial status in the patients with invasive cervical cancer. Twenty-one consecutive patients, with histologic diagnosis of cervical carcinoma, were investigated. All of them were clinically considered as having invasive cervical cancer (FIGO stage IB-IIB) and subsequently underwent surgery. In all cases, detailed histology of the parametrium was obtained. Pathological data were compared with CT and MR findings in all cases. As for assessing parametrial involvement by cancer, CT had 62% accuracy, 63% sensitivity, and 60% specificity, versus MR imaging 81% accuracy, 69% sensitivity, and 80% specificify. Therefore, MR imaging appears to be superior to CT in assessing the parametrial status of patients with invasive cervical carcinoma; the method yields valuable information for treatment planning

  4. Stage 2 carcinoma of the cervix

    International Nuclear Information System (INIS)

    Abayomi, O.

    1990-01-01

    This is a retrospective analysis of the results of 24 patients with bulky stage 2 carcinoma of the cervix treated with full course irradiation followed by adjunctive surgery between 1975 and 1980. A review of the surgical specimens following irradiation showed that 12 patients had no residual cancer, five had only microscopic foci of cancer, and five had extensive residual cancer. Two patients had unresectable persistent cancer. Six patients had histological evidence of lymph node metastases prior to irradiation. The surgical-pathological findings following irradiation had important prognostic implications. All five patients with extensive residual cancer in the surgical specimen recurred, 2 of 5 patients with only microscopic foci of residual cancer and, none of the 12 patients with no residual cancer in the resected specimens developed a recurrence. Lymph node involvement was not associated with an increased incidence of recurrence. Most patients with residual cancer following full course irradiation recurred locally. Thus the addition of adjunctive surgery following full course irradiation did not significantly improve the treatment results of patients with bulky stage 2 carcinoma of the cervix. (author). 14 refs.; 2 figs

  5. Delayed Single Stage Perineal Posterior Urethroplasty

    International Nuclear Information System (INIS)

    Ali, S.; Shahnawaz; Shahzad, I.; Baloch, M. U.

    2015-01-01

    Objective: To determine the delayed single stage perineal posterior urethroplasty for treatment of posterior urethral stricture/distraction defect. Study Design: Descriptive case series. Place and Duration of Study: Department of Urology, Jinnah Postgraduate Medical Centre, Karachi, from January 2009 to December 2011. Methodology: Patients were selected for delayed single stage perineal posterior urethroplasty for treatment of posterior urethral stricture / distraction defect. All were initially suprapubically catheterized followed by definitive surgery after at least 3 months. Results: Thirty male patients were analyzed with a mean follow-up of 10 months, 2 patients were excluded as they developed failure in first 3 months postoperatively. Mean patients age was 26.25 ± 7.9 years. On follow-up, 7 patients (23.3 percentage) experienced recurrent stricture during first 10 months. Five (16.6 percentage) patients were treated successfully with single direct visual internal urethrotomy. Two patients (6.6 percentage) had more than one direct visual internal urethrotomy and considered failed. Re-do perineal urethroplasty was eventually performed. The overall success rate was 93.3 percentage with permissive criteria allowing single direct visual internal urethrotomy and 76.6% with strict criteria allowing no more procedures postoperatively. Conclusion: Posterior anastomotic urethroplasty offers excellent long-term results to patients with posterior urethral trauma and distraction defect even after multiple prior procedures. (author)

  6. Two-Stage Modelling Of Random Phenomena

    Science.gov (United States)

    Barańska, Anna

    2015-12-01

    The main objective of this publication was to present a two-stage algorithm of modelling random phenomena, based on multidimensional function modelling, on the example of modelling the real estate market for the purpose of real estate valuation and estimation of model parameters of foundations vertical displacements. The first stage of the presented algorithm includes a selection of a suitable form of the function model. In the classical algorithms, based on function modelling, prediction of the dependent variable is its value obtained directly from the model. The better the model reflects a relationship between the independent variables and their effect on the dependent variable, the more reliable is the model value. In this paper, an algorithm has been proposed which comprises adjustment of the value obtained from the model with a random correction determined from the residuals of the model for these cases which, in a separate analysis, were considered to be the most similar to the object for which we want to model the dependent variable. The effect of applying the developed quantitative procedures for calculating the corrections and qualitative methods to assess the similarity on the final outcome of the prediction and its accuracy, was examined by statistical methods, mainly using appropriate parametric tests of significance. The idea of the presented algorithm has been designed so as to approximate the value of the dependent variable of the studied phenomenon to its value in reality and, at the same time, to have it "smoothed out" by a well fitted modelling function.

  7. Concept of white light in stage lighting

    Science.gov (United States)

    Rinaldi, Mauricio R.

    2002-06-01

    In perceiving objects, generally we see them in a white light situation. But, actually, there is not an absolute white, in such a manner that the different light sources have a determined kind of white, what it is known as color temperature. Even the white light may be of different kinds (different color temperature), the individual mind tends to perceive it as the same kind of white, that is to say, there is in our mind a psychological function by which we operate an integration in the perception in order to do the object perceptually invariable. On the other hand, it is a common practice in stage lighting to use color light sources. It is a well known phenomenon that a color of light produces a change in the object color perception. However, when we go to theater, we see the objects as having their real color, even if the lighting is not white. In this paper the concept of white light in stage lighting is presented, showing its possibilities of aesthetical expression.

  8. CT in the staging of bronchogenic carcinoma

    International Nuclear Information System (INIS)

    McLoud, T.C.; Kosiuk, J.P.; Templeton, P.A.; Shepard, J.O.; Moore, E.H.; Mathisen, D.J.; Wain, J.C.; Grillo, H.C.

    1989-01-01

    The authors previously presented a study of the accuracy of CT in the staging of bronchogenic carcinoma by means of correlative lymph node mapping and sampling in 85 patients. This study has now been extended to include 143 patients. Abnormal nodes (greater than or equal to 1 cm) were localized according to the ATS classification of regional lymph node mapping. One hundred thirty-eight patients underwent mediastinoscopy and 116, thoracotomy. In each case, lymph node groups 2R, 4R, 2L, 4L (paratracheal), 7 (subcarinal), and 5 (aorticopulmonary) underwent biopsy on the appropriate sides. Hilar nodes were resected with the surgical specimen. A total of 554 nodes were sampled. Overall sensitivity of CT for all the lymph node groups was similar to the previous study and was 40.5% with a specificity of 84.2%. Sensitivity was highest for group 5 (83%), and lowest for the subcarinal area (25%) (group 7). Specificity ranged from 71% for 10R hilar nodes to 90% for the subcarinal nodes. The positive predictive value was 34% and the negative predictive value was 87%. This study corroborates the authors' previous results and shows that when careful correlation of individual lymph nodes groups identified on CT is done with those sampled at surgery, the accuracy of CT in staging bronchogenic carcinoma is limited

  9. Mingle with Teachers in Physics on Stage

    CERN Multimedia

    2000-01-01

    'Physics on Stage' is an international festival where 450 physics educators from 22 European countries will gather at CERN from 6 to 10 November to show how fascinating and entertaining physics can be. In a week-long event innovative methods of teaching physics and demonstrations of the fun that lies in physics will be presented in a fair, in spectacular performances, and presentations. The performances of Physics on Stage will be held in the Amphitheatre but unfortunately the seats will be all taken by the delegates. However, a live transmission will be organised so CERN staff can watch the event on screen in the following locations: For Monday 6 November in the LHC Amphitheatre all day. For Tuesday 7 November in the LHC Amphitheatre and the SL Amphitheatre. For Wednesday 8 November in the LHC and PS Amphitheatres. For Thursday 9 November in the LHC and SL and after 12.00 in the PS Amphitheatre too. Because of the event the main restaurant will be closed on Thursday 9 November after 14.00. So plan you...

  10. The stages of modernism in Serbian music

    Directory of Open Access Journals (Sweden)

    Milin Melita

    2006-01-01

    Full Text Available In order to consider this topic, it was first necessary to discuss certain problems of terminology and periodisation relating to musical modernism in general. It is already familiar the extent to which the terms "new music", "modernist", "contemporary" and "avant-garde" music have been used interchangeably, as synonyms. For this reason, it was first important to outline the period of musical modernism as almost generally accepted, which is regarded as an epoch comprising three different periods: (I period of early modernism (1890–1918, announced by a break with later romanticism and a turn towards French Impressionism, Austro-German Expressionism and Russian "folkloric Expressionism"; (II period of "classical modernism"(1919–1945 that witnessed a diffusion of neo-classicism and serialism; (III period of "high modernism" (1946–1972 characterized by highly experimental compositional techniques such as integral serialism and aleatoricism. In relation to this, avant-garde movements are seen as radically innovative and subversive tendencies within this modernist epoch, and while certain postmodernist ideas can be recognized as early as the 1950s, postmodernism as a movement hadn’t gained its full potency until the 1970s. Since then, it has assumed different forms of existence as well as having assimilated a continued form of ‘modernist project’. The second part of the article proposes a periodisation of Serbian musical modernism, which is divided into four stages. The first stage (1908–1945 was a period where elements of Impressionism and German expressionism were creatively introduced into the works of several leading composers (Petar Konjović, Stevan Hristić, Miloje Milojević, Josip Slavenski, Marko Tajčević. The second stage (1929–1945 was marked by a group of composers who studied in Prague and assimilated certain progressive compositional techniques such as free tonality, atonality dodecaphony, microtonality and athematicism

  11. Comparison of single-stage and temperature-phased two-stage anaerobic digestion of oily food waste

    International Nuclear Information System (INIS)

    Wu, Li-Jie; Kobayashi, Takuro; Li, Yu-You; Xu, Kai-Qin

    2015-01-01

    Highlights: • A single-stage and two two-stage anaerobic systems were synchronously operated. • Similar methane production 0.44 L/g VS added from oily food waste was achieved. • The first stage of the two-stage process became inefficient due to serious pH drop. • Recycle favored the hythan production in the two-stage digestion. • The conversion of unsaturated fatty acids was enhanced by recycle introduction. - Abstract: Anaerobic digestion is an effective technology to recover energy from oily food waste. A single-stage system and temperature-phased two-stage systems with and without recycle for anaerobic digestion of oily food waste were constructed to compare the operation performances. The synchronous operation indicated the similar ability to produce methane in the three systems, with a methane yield of 0.44 L/g VS added . The pH drop to less than 4.0 in the first stage of two-stage system without recycle resulted in poor hydrolysis, and methane or hydrogen was not produced in this stage. Alkalinity supplement from the second stage of two-stage system with recycle improved pH in the first stage to 5.4. Consequently, 35.3% of the particulate COD in the influent was reduced in the first stage of two-stage system with recycle according to a COD mass balance, and hydrogen was produced with a percentage of 31.7%, accordingly. Similar solids and organic matter were removed in the single-stage system and two-stage system without recycle. More lipid degradation and the conversion of long-chain fatty acids were achieved in the single-stage system. Recycling was proved to be effective in promoting the conversion of unsaturated long-chain fatty acids into saturated fatty acids in the two-stage system.

  12. [Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документ�

    Index Scriptorium Estoniae

    Levans, Andris, 1968-

    2011-01-01

    Arvustus: Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документы комплекса Moscowitica-Ruthenica об отношениях Смоленска и Риги /koostajad Leksanders Ivanovs, Anatolijs Kuzņcovs. Vēstures avoti ; 6 (Riga: Latvijas Valsts vēstures arcīva izdevniecība, 2009)

  13. [Денис Хрусталëв. Северные крестоносцы: Русь в борьбе за сферы влияния в Восточной Прибалтике XII-XIII вв.] / Andris Šnē

    Index Scriptorium Estoniae

    Šnē, Andris, 1973-

    2012-01-01

    Arvustus: Хрусталëв, Денис. Северные крестоносцы: Русь в борьбе за сферы влияния в Восточной Прибалтике XII-XIII вв. (Санкт-Петербург: Евразия, 2009)

  14. Two-Stage Adaptive Optimal Design with Fixed First-Stage Sample Size

    Directory of Open Access Journals (Sweden)

    Adam Lane

    2012-01-01

    Full Text Available In adaptive optimal procedures, the design at each stage is an estimate of the optimal design based on all previous data. Asymptotics for regular models with fixed number of stages are straightforward if one assumes the sample size of each stage goes to infinity with the overall sample size. However, it is not uncommon for a small pilot study of fixed size to be followed by a much larger experiment. We study the large sample behavior of such studies. For simplicity, we assume a nonlinear regression model with normal errors. We show that the distribution of the maximum likelihood estimates converges to a scale mixture family of normal random variables. Then, for a one parameter exponential mean function we derive the asymptotic distribution of the maximum likelihood estimate explicitly and present a simulation to compare the characteristics of this asymptotic distribution with some commonly used alternatives.

  15. A proposed staging system and stage-specific interventions for familial adenomatous polyposis

    DEFF Research Database (Denmark)

    Lynch, Patrick M; Morris, Jeffrey S; Wen, Sijin

    2016-01-01

    BACKGROUND: It is not possible to accurately count adenomas in many patients with familial adenomatous polyposis (FAP). Nevertheless, polyp counts are critical in evaluating each patient's response to interventions. However, the U.S. Food and Drug Administration no longer recognizes the decrease...... classification scheme for lower GI tract polyposis. METHODS: Twenty-four colonoscopy or sigmoidoscopy videos were reviewed by 26 clinicians familiar with diagnosis and treatment of FAP. The reviewers independently assigned a stage to a case using the proposed system and chose a stage-specific intervention...... in the review of individual cases of polyposis. Therefore, reliable and clinically relevant means for measuring trial outcomes can be developed. Outlier cases showing wide scatter in stage assignment call for individualized attention and may be inappropriate for enrollment in clinical trials for this reason....

  16. Health insurance and stage at diagnosis of laryngeal cancer: does insurance type predict stage at diagnosis?

    Science.gov (United States)

    Chen, Amy Y; Schrag, Nicole M; Halpern, Michael; Stewart, Andrew; Ward, Elizabeth M

    2007-08-01

    To examine whether patients with no insurance or Medicaid are more likely to present with advanced-stage laryngeal cancer. Retrospective cohort study from the National Cancer Database, 1996-2003. Hospital-based practice. Patients with known insurance status diagnosed as having invasive laryngeal cancer at Commission on Cancer facilities (N = 61 131) were included. Adjusted and unadjusted logistic regression models analyzed the likelihood of presenting at a more advanced stage. Overall stage of laryngeal cancer (early vs advanced) and tumor size (T stage) at diagnosis. Patients with advanced-stage laryngeal cancer at diagnosis were more likely to be uninsured (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.79-2.15) or covered by Medicaid (OR, 2.40; 95% CI, 2.21-2.61) compared with those with private insurance. Similarly, patients were most likely to present with the largest tumors (T4 disease) if they were uninsured (OR, 2.92; 95% CI, 2.60-3.28) or covered by Medicaid (OR, 3.97; 95% CI, 3.56-4.34). Patients who were black, between ages 18 and 56 years, and who resided in zip codes with low proportions of high school graduates or low median household incomes were also more likely to be diagnosed as having advanced disease and/or larger tumors. Individuals lacking insurance or having Medicaid are at greatest risk for presenting with advanced laryngeal cancer. Results for the Medicaid group may be influenced by the postdiagnosis enrollment of uninsured patients. It is important to consider the impact of insurance coverage on stage at diagnosis and associated morbidity, mortality, quality of life, and costs.

  17. A Novel Inflammation-Based Stage (I Stage Predicts Overall Survival of Patients with Nasopharyngeal Carcinoma

    Directory of Open Access Journals (Sweden)

    Jian-Pei Li

    2016-11-01

    Full Text Available Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS, modified GPS (mGPS and C-reactive protein/Albumin (CRP/Alb ratio, platelet–lymphocyte ratio (PLR, and neutrophil–lymphocyte ratio (NLR, have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC. In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted. The prognostic factors (GPS, mGPS, CRP/Alb ratios, PLR, and NLR were evaluated using univariate and multivariate analyses. Then, according to the results of the multivariate analyses, we proposed a I stage combination of independent risk factors (CRP/Alb ratio and PLR. The I stage was calculated as follows: patients with high levels of CRP/Alb ratio (>0.03 and PLR (>146.2 were defined as I2; patients with one or no abnormal values were defined as I1 or I0, respectively. The relationships between the I stage and clinicopathological variables and overall survival (OS were evaluated. In addition, the discriminatory ability of the I stage with other inflammation-based prognostic scores was assessed using the AUCs (areas under the curves analyzed by receiver operating characteristics (ROC curves. The p value of <0.05 was considered to be significant. A total of 409 patients with NPC were enrolled in this study. Multivariate analyses revealed that only the CRP/Alb ratio (Hazard ratio (HR = 2.093; 95% Confidence interval (CI: 1.222–3.587; p = 0.007 and PLR (HR: 2.003; 95% CI: 1.177–3.410; p = 0.010 were independent prognostic factors in patients with NPC. The five-year overall survival rates for patients with I0, I1, and I2 were 92.1% ± 2.9%, 83.3% ± 2.6%, and 63.1% ± 4.6%, respectively (p < 0.001. The I stage had a higher area under the curve value (0.670 compared with other systemic inflammation

  18. [Complications of surgical stage of treatment in patients with cancer of cervix uteri stage IIB].

    Science.gov (United States)

    Kryzhanivs'ka, A Ie

    2013-11-01

    The results of treatment of 127 patients, suffering cervix uteri cancer stage IIB in period of 1998 - 2012 yrs, were analyzed. Complications of surgical stage of the combined treatment have had occurred in 40.9% patients, including 40.5% patients, to whom neoadjuvant chemotherapy was conducted and in 41.5%--radiation therapy (RTH). The main postoperative complications--retroperitoneal lymphatic cysts--were revealed in 35.4% patients. The factors, raising the risk of postoperative complications occurrence, are following: the primary tumor spreading, metastatic affection of lymphatic nodes of pelvic cavity, preoperative conduction of RTH or chemotherapy.

  19. Upper Stage Engine Composite Nozzle Extensions

    Science.gov (United States)

    Valentine, Peter G.; Allen, Lee R.; Gradl, Paul R.; Greene, Sandra E.; Sullivan, Brian J.; Weller, Leslie J.; Koenig, John R.; Cuneo, Jacques C.; Thompson, James; Brown, Aaron; hide

    2015-01-01

    Carbon-carbon (C-C) composite nozzle extensions are of interest for use on a variety of launch vehicle upper stage engines and in-space propulsion systems. The C-C nozzle extension technology and test capabilities being developed are intended to support National Aeronautics and Space Administration (NASA) and United States Air Force (USAF) requirements, as well as broader industry needs. Recent and on-going efforts at the Marshall Space Flight Center (MSFC) are aimed at both (a) further developing the technology and databases for nozzle extensions fabricated from specific CC materials, and (b) developing and demonstrating low-cost capabilities for testing composite nozzle extensions. At present, materials development work is concentrating on developing a database for lyocell-based C-C that can be used for upper stage engine nozzle extension design, modeling, and analysis efforts. Lyocell-based C-C behaves in a manner similar to rayon-based CC, but does not have the environmental issues associated with the use of rayon. Future work will also further investigate technology and database gaps and needs for more-established polyacrylonitrile- (PAN-) based C-C's. As a low-cost means of being able to rapidly test and screen nozzle extension materials and structures, MSFC has recently established and demonstrated a test rig at MSFC's Test Stand (TS) 115 for testing subscale nozzle extensions with 3.5-inch inside diameters at the attachment plane. Test durations of up to 120 seconds have been demonstrated using oxygen/hydrogen propellants. Other propellant combinations, including the use of hydrocarbon fuels, can be used if desired. Another test capability being developed will allow the testing of larger nozzle extensions (13.5- inch inside diameters at the attachment plane) in environments more similar to those of actual oxygen/hydrogen upper stage engines. Two C-C nozzle extensions (one lyocell-based, one PAN-based) have been fabricated for testing with the larger

  20. Two-stage unilateral versus one-stage bilateral single-port sympathectomy for palmar and axillary hyperhidrosis†

    Science.gov (United States)

    Ibrahim, Mohsen; Menna, Cecilia; Andreetti, Claudio; Ciccone, Anna Maria; D'Andrilli, Antonio; Maurizi, Giulio; Poggi, Camilla; Vanni, Camilla; Venuta, Federico; Rendina, Erino Angelo

    2013-01-01

    OBJECTIVES Video-assisted thoracoscopic sympathectomy is currently the best treatment for palmar and axillary hyperhidrosis. It can be performed through either one or two stages of surgery. This study aimed to evaluate the operative and postoperative results of two-stage unilateral vs one-stage bilateral thoracoscopic sympathectomy. METHODS From November 1995 to February 2011, 270 patients with severe palmar and/or axillary hyperhidrosis were recruited for this study. One hundred and thirty patients received one-stage bilateral, single-port video-assisted thoracoscopic sympathectomy (one-stage group) and 140, two-stage unilateral, single-port video-assisted thoracoscopic sympathectomy, with a mean time interval of 4 months between the procedures (two-stage group). RESULTS The mean postoperative follow-up period was 12.5 (range: 1–24 months). After surgery, hands and axillae of all patients were dry and warm. Sixteen (12%) patients of the one-stage group and 15 (11%) of the two-stage group suffered from mild/moderate pain (P = 0.8482). The mean operative time was 38 ± 5 min in the one-stage group and 39 ± 8 min in the two-stage group (P = 0.199). Pneumothorax occurred in 8 (6%) patients of the one-stage group and in 11 (8%) of the two-stage group. Compensatory sweating occurred in 25 (19%) patients of the one-stage group and in 6 (4%) of the two-stage group (P = 0.0001). No patients developed Horner's syndrome. CONCLUSIONS Both two-stage unilateral and one-stage bilateral single-port video-assisted thoracoscopic sympathectomies are effective, safe and minimally invasive procedures. Two-stage unilateral sympathectomy can be performed with a lower occurrence of compensatory sweating, improving permanently the quality of life in patients with palmar and axillary hyperhidrosis. PMID:23442937

  1. Autobiographic Performance. Intimacy as a Stage Practice

    Directory of Open Access Journals (Sweden)

    Josefina Alcázar

    2015-11-01

    Full Text Available This essay analyses performance as an expression of the age of intimacy, an age we are currently living through, where self-representation takes on a multiplicity and heterogeneity of registers and strategies. In autobiographic performance the boundary between the public and the private becomes blurred, which is expressive of the transformation of contemporary subjectivity, a search of the experience of living, and an urge to publicise intimacy. It is based on everyday life, the smaller things, not the important issues but the occurrence of the usual as it happens day by day. Performance, or action art, is an art of the self which is framed within this context of revealing one’s intimacy; and this is what makes it akin to several forms of searching for identity and self-knowledge, in which artists put their own subjectivity up on the stage.

  2. Imaging and staging of haemophilic arthropathy

    Energy Technology Data Exchange (ETDEWEB)

    Jelbert, A.; Vaidya, S. [Radiology Department, Barts and The London NHS trust, London (United Kingdom); Fotiadis, N., E-mail: nicos.fotiadis@bartsandthelondon.nhs.u [Radiology Department, Barts and The London NHS trust, London (United Kingdom)

    2009-11-15

    Arthropathy is one of the most disabling consequences of haemophilia. The management of this condition has been revolutionized by the introduction of prophylactic treatment with clotting factor replacements. In order for benefits of this treatment to be monitored, the severity of any joint disease needs to be accurately assessed. Diagnostic imaging is used to objectively evaluate haemophilic arthropathy (HA). There are several established scoring systems for grading HA based on conventional radiography and magnetic resonance imaging (MRI). In this review the role of the different imaging methods in the evaluation of HA are discussed, the established staging systems are presented, and an explanation of why MRI is becoming the primary method of joint imaging in HA is provided.

  3. Multiple Imputation in Three or More Stages.

    Science.gov (United States)

    McGinniss, J; Harel, O

    2016-09-01

    Missing values present challenges in the analysis of data across many areas of research. Handling incomplete data incorrectly can lead to bias, over-confident intervals, and inaccurate inferences. One principled method of handling incomplete data is multiple imputation. This article considers incomplete data in which values are missing for three or more qualitatively different reasons and applies a modified multiple imputation framework in the analysis of that data. Included are a proof of the methodology used for three-stage multiple imputation with its limiting distribution, an extension to more than three types of missing values, an extension to the ignorability assumption with proof, and simulations demonstrating that the estimator is unbiased and efficient under the ignorability assumption.

  4. Breakeven Fusion in Staged Z Pinch

    Science.gov (United States)

    Rahman, Hafiz; Ney, Paul; Rostoker, Norman; Wessel, Frank

    2008-03-01

    We are studying the prospect for breakeven thermonuclear fusion considering a Mega joule (MJ) class, 100 ns, impulse generator using a modified version of MACH2, a 2-1/2 D, radiation-code. The load is a cylindrical, xenon plasma shell that implodes radially onto a co-axial, deuterium-tritium plasma target. Optimized plasma density and pinch radius lead to a fusion-energy output that is many times the stored capacitor bank energy. In this ``Staged Z-pinch'' shock fronts form that preheat the DT plasma to several hundred eV, before adiabatic compression. During compression, the Xe liner becomes Rayleigh-Taylor (RT) unstable while the DT target remains stable. Proper selection of the initial pinch radius and plasma density is crucial for optimum implosion efficiency.

  5. Nuclear Cryogenic Propulsion Stage for Mars Exploration

    Science.gov (United States)

    Houts, M. G.; Borowski, S. K.; George, J. A.; Kim, T.; Emrich, W. J.; Hickman, R. R.; Broadway, J. W.; Gerrish, H. P.; Adams, R. B.

    2012-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced Nuclear Electric Propulsion (NEP).

  6. Atherosclerosis staging: imaging using FLIM technique

    Science.gov (United States)

    Sicchieri, Leticia B.; Barioni, Marina Berardi; Silva, Mônica Nascimento; Monteiro, Andrea Moreira; Figueiredo Neto, Antonio Martins; Ito, Amando S.; Courrol, Lilia C.

    2014-03-01

    In this work it was used fluorescence lifetime imaging (FLIM) to analyze biochemical composition of atherosclerotic plaque. For this purpose an animal experimentation was done with New Zealand rabbits divided into two groups: a control group of 4 rabbits that received a regular diet for 0, 20, 40 and 60 days; and an experimental group of 9 rabbits, divided in 3 subgroups, that were fed with 1% cholesterol diet for 20, 40 and 60 days respectively. The aortas slices stained with europium chlortetracycline were analyzed by FLIM exciting samples at 440 nm. The results shown an increase in the lifetime imaging of rabbits fed with cholesterol. It was observed that is possible to detect the metabolic changes associated with atherosclerosis at an early stage using FLIM technique exciting the tissue around 440 nm and observing autofluorescence lifetime. Lifetimes longer than 1.75 ns suggest the presence of porphyrins in the tissue and consequently, inflammation and the presence of macrophages.

  7. STAGES OF A STRATEGIC MANAGEMENT MODEL

    Directory of Open Access Journals (Sweden)

    Mihaela – Lavinia CIOBANICA

    2014-06-01

    Full Text Available In the literature dedicated to strategic management there is no unitary vision of the authors regarding the sequence of actions that give content to the respective process and what their stages are. With all existing differences, the visions of different authors nevertheless observe the unitary logic of developing a series of actions. These actions begin with the competitive environment analysis in which the organization operates and with the establishment of its strategic mission and they end with the performance evaluation after the strategy has been applied and, if appropriate, with the reconsidering of this strategy and the making of the necessary corrections to it. Such a basic structure of the process is adopted in most organizations that practice the strategic management. But noticeable differences appear in the degree of the formalization of the process and in the involvement of different managerial levels in the designing and detailing of its components.

  8. Nuclear Cryogenic Propulsion Stage Affordable Development Strategy

    Science.gov (United States)

    Doughty, Glen E.; Gerrish, H. P.; Kenny, R. J.

    2014-01-01

    The development of nuclear power for space use in nuclear thermal propulsion (NTP) systems will involve significant expenditures of funds and require major technology development efforts. The development effort must be economically viable yet sufficient to validate the systems designed. Efforts are underway within the National Aeronautics and Space Administration's (NASA) Nuclear Cryogenic Propulsion Stage Project (NCPS) to study what a viable program would entail. The study will produce an integrated schedule, cost estimate and technology development plan. This will include the evaluation of various options for test facilities, types of testing and use of the engine, components, and technology developed. A "Human Rating" approach will also be developed and factored into the schedule, budget and technology development approach.

  9. Imaging and staging of haemophilic arthropathy

    International Nuclear Information System (INIS)

    Jelbert, A.; Vaidya, S.; Fotiadis, N.

    2009-01-01

    Arthropathy is one of the most disabling consequences of haemophilia. The management of this condition has been revolutionized by the introduction of prophylactic treatment with clotting factor replacements. In order for benefits of this treatment to be monitored, the severity of any joint disease needs to be accurately assessed. Diagnostic imaging is used to objectively evaluate haemophilic arthropathy (HA). There are several established scoring systems for grading HA based on conventional radiography and magnetic resonance imaging (MRI). In this review the role of the different imaging methods in the evaluation of HA are discussed, the established staging systems are presented, and an explanation of why MRI is becoming the primary method of joint imaging in HA is provided.

  10. Staging as a Methodological Tool for Anthropology

    Directory of Open Access Journals (Sweden)

    Miren Urquijo

    2017-12-01

    Full Text Available My theatrical background has conditioned my approach to anthropology. This dramaturgical focus in the study of social life has encouraged the articulation of my theatrical and anthropological experience in staging. This paper explains how and why this is a valid tool for anthropology and for the performative study of the gender system, the assessment of the role of normativity and social structure in its representation. I have experimented with and expressed the process of constructing a dramaturgical and anthropological logic as an autobiographical exercise. The social theories which have influenced me include dynamic situationism, dynamic interactionism and constructivist theories which address the body as social fiction. With all of this, I have elaborated an interpretative strategy for the description, analysis and perception of reality. Publishing it means sharing it and submitting it to evaluation.

  11. Coexistence of competing stage-structured populations.

    KAUST Repository

    Fujiwara, Masami

    2011-10-05

    This paper analyzes the stability of a coexistence equilibrium point of a model for competition between two stage-structured populations. In this model, for each population, competition for resources may affect any one of the following population parameters: reproduction, juvenile survival, maturation rate, or adult survival. The results show that the competitive strength of a population is affected by (1) the ratio of the population parameter influenced by competition under no resource limitation (maximum compensatory capacity) over the same parameter under a resource limitation due to competition (equilibrium rate) and (2) the ratio of interspecific competition over intraspecific competition; this ratio was previously shown to depend on resource-use overlap. The former ratio, which we define as fitness, can be equalized by adjusting organisms\\' life history strategies, thereby promoting coexistence. We conclude that in addition to niche differentiation among populations, the life history strategies of organisms play an important role in coexistence.

  12. Staging constructions of authenticity in organizational change

    DEFF Research Database (Denmark)

    Dupret, Katia

    2018-01-01

    that are emotionally charged. Through a socio-material perspective this paper seeks to explore how change processes in organizations challenges the idea of authentic leadership as a merely individual ability or personality trait and suggest that the authentic leader is distributed into the practices of change......Authenticity in organizations has gained increased focus in recent years. Authentic management and leadership are ways to motivate and make sustainable changes in the organization. But authenticity is also strategically worked with in order to serve social and political functions....... The paper explores how staged organizational change where authentic role-play and scripts from everyday life combined with meta-reflection and feedback construct new forms of reflection where its ethical side-effects should be discussed....

  13. Integrated Solar Upper Stage Technical Support

    Science.gov (United States)

    Jaworske, Donald A.

    1998-01-01

    NASA Lewis Research Center is participating in the Integrated Solar Upper Stage (ISUS) program. This program is a ground-based demonstration of an upper stage concept that will be used to generate both solar propulsion and solar power. Solar energy collected by a primary concentrator is directed into the aperture of a secondary concentrator and further concentrated into the aperture of a heat receiver. The energy stored in the receiver-absorber-converter is used to heat hydrogen gas to provide propulsion during the orbital transfer portion of the mission. During the balance of the mission, electric power is generated by thermionic diodes. Several materials issues were addressed as part of the technical support portion of the ISUS program, including: 1) Evaluation of primary concentrator coupons; 2) Evaluation of secondary concentrator coupons; 3) Evaluation of receiver-absorber-converter coupons; 4) Evaluation of in-test witness coupons. Two different types of primary concentrator coupons were evaluated from two different contractors-replicated coupons made from graphite-epoxy composite and coupons made from microsheet glass. Specular reflectivity measurements identified the replicated graphite-epoxy composite coupons as the primary concentrator material of choice. Several different secondary concentrator materials were evaluated, including a variety of silver and rhodium reflectors. The specular reflectivity of these materials was evaluated under vacuum at temperatures up to 800 C. The optical properties of several coupons of rhenium on graphite were evaluated to predict the thermal performance of the receiver-absorber-converter. Finally, during the ground test demonstration, witness coupons placed in strategic locations throughout the thermal vacuum facility were evaluated for contaminants. All testing for the ISUS program was completed successfully in 1997. Investigations related to materials issues have proven helpful in understanding the operation of the test

  14. Stages of educational development? Beeby revisited

    Science.gov (United States)

    Guthrie, Gerard

    1980-12-01

    Beeby's model of stages of educational change in developing countries has been accepted into the educational literature with remarkably little critical analysis. Though valuable for a large number of experiential insights, the author argues that the model has certain weaknesses which should restrict its application. The stages have a teleological bias and are not sufficiently distinct, nor do the labels used for them meet the formal requirements of measuring scales. Furthermore, the model overgeneralizes from the experience of British-tradition South Pacific school systems, and the equation of western teaching with good teaching is an unsupported view which may not be valid in many countries. The most fundamental problem is the lack of clear distinction between empirical issues and the ethical judgements implicit in the formulation. However, the model has a number of positive features well worth building upon, such as its focus on the qualitative aspects of teaching and on qualitative change, the realistic emphasis on the gradualism of such change in practice, and the identification of the teacher as the key change agent in the classroom — a fundamental point often overlooked by innovators. The continua of general and professional education which underlie the teaching styles provide useful hypotheses for empirical analysis of the relationship between teacher education and classroom teaching style, but the association of this education with certain types of teaching style needs careful examination. Stripped of its evaluative connotations, Beeby's interest in qualitative change was a valuable early attempt to move attention in developing countries from linear, quantitative expansion of existing systems to a consideration of what was actually being taught and how. The real lesson to be learned from his work is that education should be paying closer attention to its theoretical propositions.

  15. Staging colorectal cancer with the TNM 7(th)

    DEFF Research Database (Denmark)

    Puppa, Giacomo; Poston, Graeme; Jess, Per

    2013-01-01

    lesions encountered, in particular, during radiological staging of patients with colorectal cancer. In this article the diagnosis of these lesions with multiple imaging modalities, their frequency, significance and relevance to staging and disease management are described in a multidisciplinary way...

  16. Preoperative staging of lung cancer with combined PET-CT

    DEFF Research Database (Denmark)

    Fischer, Barbara; Lassen, Ulrik; Mortensen, Jann

    2009-01-01

    BACKGROUND: Fast and accurate staging is essential for choosing treatment for non-small-cell lung cancer (NSCLC). The purpose of this randomized study was to evaluate the clinical effect of combined positron-emission tomography and computed tomography (PET-CT) on preoperative staging of NSCLC....... METHODS: We randomly assigned patients who were referred for preoperative staging of NSCLC to either conventional staging plus PET-CT or conventional staging alone. Patients were followed until death or for at least 12 months. The primary end point was the number of futile thoracotomies, defined as any...... one of the following: a thoracotomy with the finding of pathologically confirmed mediastinal lymph-node involvement (stage IIIA [N2]), stage IIIB or stage IV disease, or a benign lung lesion; an exploratory thoracotomy; or a thoracotomy in a patient who had recurrent disease or death from any cause...

  17. NLV Upper Stage Development and Flight Testing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The technical innovation proposed here is the design during Phase I of a high performance upper stage for a two-stage "20 / 450" Nanosat Launch Vehicle (NLV) that is...

  18. Composite likelihood and two-stage estimation in family studies

    DEFF Research Database (Denmark)

    Andersen, Elisabeth Anne Wreford

    2002-01-01

    Composite likelihood; Two-stage estimation; Family studies; Copula; Optimal weights; All possible pairs......Composite likelihood; Two-stage estimation; Family studies; Copula; Optimal weights; All possible pairs...

  19. Ages and Career Stages: Considerations in Providing Support for Mid-Late Career Stage Doctoral Students

    Science.gov (United States)

    Robertson, Margaret J.

    2017-01-01

    This article raises two inter-related issues: firstly there is a correlation between the needs of doctoral students that are strongly related to age and career stage; and secondly, because these needs differ according to their demographic, the current discourse of developing work-readiness skills of doctoral students is misplaced for the growing…

  20. One-stage and two-stage penile buccal mucosa urethroplasty

    African Journals Online (AJOL)

    G. Barbagli

    2015-12-02

    Dec 2, 2015 ... there also seems to be a trend of decreasing urethritis and an increase of instrumentation and catheter related strictures in these countries as well [4–6]. The repair of penile urethral strictures may require one- or two- stage urethroplasty [7–10]. Certainly, sexual function can be placed at risk by any surgery ...

  1. [Feedback of ultrasound and RMI in the staging of endometrial carcinoma in early stage].

    Science.gov (United States)

    Buhler, J; Routiot, T; Polet-Lefebvre, K; Morel, O

    2015-04-01

    Endometrial cancer is the most common gynecological cancer in France. The therapeutic management is based on preoperative staging. The recommended imaging examination remains the MRI. This is to evaluate ultrasound and MRI in the staging for localized cancers. This is a retrospective observational study, conducted from July 2012 to July 2014, at the University Hospital of Nancy, on all patients care for endometrial cancer stage I, who underwent a pelvic ultrasound and MRI for the assessment of myometrial infiltration. Twenty-nine patients were included with a mean age of 69 years and a BMI of 30 kg/m(2). Using ultrasound, we have a sensitivity of 58%, a specificity of 100%, a positive predictive value (PPV) of 100%, a negative predictive value (NPV) of 70% and an accuracy of 75%. Using MRI, we have a sensitivity of 83%, a specificity of 100%, a PPV of 83%, a VPN of 88%, and an accuracy of 86%. Transvaginal sonography should be performed before post-menopausal bleeding. It remains possible in the staging of localized cancers. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  2. Applying artificial intelligence to disease staging: Deep learning for improved staging of diabetic retinopathy.

    Directory of Open Access Journals (Sweden)

    Hidenori Takahashi

    Full Text Available Disease staging involves the assessment of disease severity or progression and is used for treatment selection. In diabetic retinopathy, disease staging using a wide area is more desirable than that using a limited area. We investigated if deep learning artificial intelligence (AI could be used to grade diabetic retinopathy and determine treatment and prognosis.The retrospective study analyzed 9,939 posterior pole photographs of 2,740 patients with diabetes. Nonmydriatic 45° field color fundus photographs were taken of four fields in each eye annually at Jichi Medical University between May 2011 and June 2015. A modified fully randomly initialized GoogLeNet deep learning neural network was trained on 95% of the photographs using manual modified Davis grading of three additional adjacent photographs. We graded 4,709 of the 9,939 posterior pole fundus photographs using real prognoses. In addition, 95% of the photographs were learned by the modified GoogLeNet. Main outcome measures were prevalence and bias-adjusted Fleiss' kappa (PABAK of AI staging of the remaining 5% of the photographs.The PABAK to modified Davis grading was 0.64 (accuracy, 81%; correct answer in 402 of 496 photographs. The PABAK to real prognosis grading was 0.37 (accuracy, 96%.We propose a novel AI disease-staging system for grading diabetic retinopathy that involves a retinal area not typically visualized on fundoscopy and another AI that directly suggests treatments and determines prognoses.

  3. On the robustness of two-stage estimators

    KAUST Repository

    Zhelonkin, Mikhail

    2012-04-01

    The aim of this note is to provide a general framework for the analysis of the robustness properties of a broad class of two-stage models. We derive the influence function, the change-of-variance function, and the asymptotic variance of a general two-stage M-estimator, and provide their interpretations. We illustrate our results in the case of the two-stage maximum likelihood estimator and the two-stage least squares estimator. © 2011.

  4. Cognitive phenotypes of sequential staging in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Lulé, Dorothée; Böhm, Sarah; Müller, Hans-Peter; Aho-Özhan, Helena; Keller, Jürgen; Gorges, Martin; Loose, Markus; Weishaupt, Jochen H; Uttner, Ingo; Pinkhardt, Elmar; Kassubek, Jan; Del Tredici, Kelly; Braak, Heiko; Abrahams, Sharon; Ludolph, Albert C

    2018-04-01

    Sequential spread of TDP-43 load in the brain may be a pathological characteristic of amyotrophic lateral sclerosis (ALS). Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) based marker of this pathological feature. Cognitive deficits known to be present in a subset of ALS patients might act as an additional in vivo clinical marker of disease spread. N = 139 patients with ALS were tested with the Edinburgh Cognitive and Behavioural ALS screen (ECAS) in addition to DTI brain measures of pathological spread. Executive function, memory and disinhibited behaviour were selected for Cognitive-Staging criteria, as these cognitive functions are attributed to cerebral areas analogous to the pattern of MRI markers of TDP-43 pathology. ROC curve analyses were performed to define cut-off scores for cognitive stages 2 (executive function), stage 3 (disinhibited behaviour) and stage 4 (memory), and staging was performed according to the cognitive profile subsequently. Associations of Cognitive-Staging (stage 2-4) and MRI-Staging measures were determined. In total, 77 patients (55%) performed below ROC cut-off scores in either executive function or memory or both and/or were reported to have disinhibited behaviour which permitted Cognitive-Staging. The cognitive profile of patients with discrete MRI stages 2-4 correlated significantly with DTI parameters. For those patients with cognitive impairment, there was a high congruency between MRI and Cognitive-Staging with high specificity and sensitivity of executive functions for MRI stage 2, disinhibited behaviour for MRI stage 3 and moderate of memory for MRI stage 4. Cognitive impairment follows specific patterns in ALS and these patterns can be used for Cognitive-Staging with a high specificity compared to MRI-Staging. For the individual, cognitive screening is a fast and easy to apply measurement of cerebral function giving valuable information in a clinical context. Copyright © 2018 Elsevier Ltd. All

  5. Preoperative PET/CT in early-stage breast cancer

    DEFF Research Database (Denmark)

    Bernsdorf, M; Berthelsen, A K; Wielenga, V T

    2012-01-01

    The aim of this study was to assess the diagnostic and therapeutic impact of preoperative positron emission tomography and computed tomography (PET/CT) in the initial staging of patients with early-stage breast cancer.......The aim of this study was to assess the diagnostic and therapeutic impact of preoperative positron emission tomography and computed tomography (PET/CT) in the initial staging of patients with early-stage breast cancer....

  6. ALGORITHM OF STAGE DEFINITION OF THE ORGANIZATION’S LIFECYCLE

    OpenAIRE

    Ratibor I. Sekirov

    2013-01-01

    Problem of the definition of a current stage of the lifecycle of an organization in practice is considered in the article. The purpose of this research is a development of the algorithm of stage definition of the organization’s lifecycle. The existing approaches to the stage definition of the lifecycle of the organization are considered. As a result of the research the optimal algorithm for stage definition of the organization’s lifecycle was developed.

  7. Iterative learning control for synchronization of reticle stage and wafer stage in step-and-scan lithographic equipment

    Science.gov (United States)

    Li, Lan-lan; Hu, Song; Zhao, Li-xin; Ma, Ping

    2013-08-01

    Lithographic equipments are highly complex machines used to manufacture integrated circuits (ICs). To make larger ICs, a larger lens is required, which, however, is prohibitively expensive. The solution to this problem is to expose a chip not in one flash but in a scanning fashion. For step-and-scan lithographic equipment (wafer scanner), the image quality is decided by many factors, in which synchronization of reticle stage and wafer stage during exposure is a key one. In this paper, the principle of reticle stage and wafer stage was analyzed through investigating the structure of scanners, firstly. While scanning, the reticle stage and wafer stage should scan simultaneously at a high speed and the speed ratio is 1:4. Secondly, an iterative learning controller (ILC) for synchronization of reticle stage and wafer stage is presented. In the controller, a master-slave structure is used, with the wafer stage acting as the master, and the reticle stage as the slave. Since the scanning process of scanner is repetitive, ILC is used to improve tracking performance. A simple design procedure is presented which allows design of the ILC system for the reticle stage and wafer stage independently. Finally, performance of the algorithm is illustrated by simulated on the virtual stages (the reticle stage and wafer stage).The results of simulation experiments and theory analyzing demonstrate that using the proposed controller better synchronization performance can be obtained for the reticle stage and wafer stage in scanner. Theory analysis and experiment shows the method is reasonable and efficient.

  8. Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Stage 0-III Melanoma

    Science.gov (United States)

    2017-11-15

    Stage 0 Skin Melanoma; Stage I Skin Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage II Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage III Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma

  9. Posterior tibial tendon insufficiency results at different stages.

    Science.gov (United States)

    Deland, Jonathan T; Page, Alexandra; Sung, Il-Hoon; O'Malley, Martin J; Inda, David; Choung, Steven

    2006-09-01

    The results of surgical treatment of posterior tibial tendon insufficiency (PTTI) may be different at different stages of the disease. No single study has compared the results at different stages. This comparison can be helpful to the patient and physician if the patient asks "What if I wait and the disease progresses, how will my results be different?" A preliminary study comparing results for stage IIa, stage IIb (advanced stage II), and stage III was performed followed by a larger study comparing IIa and IIb with 26 and 22 patients, respectively. American Orthopaedic Foot and Ankle Society (AOFAS) outcome scores as well as radiographs and functional questions were used. Nearly all patients, regardless of stage, felt they were helped by surgical treatment. However, the lowest AOFAS score was in stage III, the most advanced stage investigated in this study. In comparing stage IIa and IIb patients, stage IIb patients had a statistically higher incidence of lateral discomfort. Although statistically significant differences were not found in all comparisons, this study suggests that the results of surgical treatment for PTTI declines with increasing stage or severity of disease.

  10. Stages of Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer

    Science.gov (United States)

    ... the ovaries, through the fallopian tubes, to the uterus. Cancer sometimes begins at the end of the fallopian ... into stage IIA and stage IIB. Stage IIA : Cancer has spread from where it first formed to the uterus and/or the fallopian tubes and/or the ...

  11. Clinical staging of major depressive disorder: an empirical exploration

    NARCIS (Netherlands)

    Verduijn, J.; Milaneschi, Y.; van Hemert, A.M.; Schoevers, R.A.; Hickie, I.B.; Penninx, B.W.J.H.; Beekman, A.T.F.

    2015-01-01

    Objective: Clinical staging has been proposed to supplement psychiatric diagnoses. We examined the construct and predictive validity of a clinical staging model for major depressive disorder (MDD) that distinguishes 8 consecutive stages (0, 1A, 1B, 2, 3A, 3B, 3C, 4) based on symptom severity

  12. Gastric cancer : staging, treatment, and surgical quality assurance

    NARCIS (Netherlands)

    Dikken, Johannes Leen

    2012-01-01

    Research described in this thesis focuses on several aspects of gastric cancer care: staging and prognostication, multimodality treatment, and surgical quality assurance. PART I - STAGING AND PROGNOSTICATION Cancer staging is one of the fundamental activities in oncology.6,7 For over 50 years, the

  13. Second-stage primary Caesarean deliveries: Are maternal ...

    African Journals Online (AJOL)

    For the purpose of this study, the second stage of labour was defined as the full dilation of the cervix between ... For the purposes of comparison, 53 first-stage emergency CSs were obtained from the 120 first-stage CSs by ..... RCOG Clinical Effectiveness Support Unit. The. National Sentinel Caesarean Section Audit Report.

  14. Influence of growth stage at harvest on fermentative characteristics ...

    African Journals Online (AJOL)

    An experiment was conducted to investigate the influence of stage of growth at harvest on fermentative characteristics of Panicum maximum silage. The treatments were three different growth stages (early vegetative, boot and full bloom stage) that were ensiled directly or wilted prior to ensiling. Directly ensiled and wilted ...

  15. Research Productivity by Career Stage among Korean Academics

    Science.gov (United States)

    Jung, Jisun

    2014-01-01

    This study explores Korean academics' changes in research productivity by career stage. Career stage in this study is defined as a specific cohort based on one's length of job experience, with those in the same stage sharing similar interests, values, needs, and tasks; it is categorized into fledglings, maturing academics, established academics,…

  16. Natural History of Progression of Chronic Kidney Disease in Stages ...

    African Journals Online (AJOL)

    Introduction: Patients with chronic kidney disease (CKD) often continue to progress spontaneously towards end stage renal disease (ESRD). In this report we studied the natural history of progression of CKD in a cohort of patients with stage 4 and 5 CKD. Methods: We retrospectively studied a cohort of patients in stage 4 ...

  17. 42 CFR 441.40 - End-stage renal disease.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false End-stage renal disease. 441.40 Section 441.40... General Provisions § 441.40 End-stage renal disease. FFP in expenditures for services described in subpart A of part 440 is available for facility treatment of end-stage renal disease only if the facility...

  18. Implications of inaccurate clinical nodal staging in pancreatic adenocarcinoma.

    Science.gov (United States)

    Swords, Douglas S; Firpo, Matthew A; Johnson, Kirsten M; Boucher, Kenneth M; Scaife, Courtney L; Mulvihill, Sean J

    2017-07-01

    Many patients with stage I-II pancreatic adenocarcinoma do not undergo resection. We hypothesized that (1) clinical staging underestimates nodal involvement, causing stage IIB to have a greater percent of resected patients and (2) this stage-shift causes discrepancies in observed survival. The Surveillance, Epidemiology, and End Results (SEER) research database was used to evaluate cause-specific survival in patients with pancreatic adenocarcinoma from 2004-2012. Survival was compared using the log-rank test. Single-center data on 105 patients who underwent resection of pancreatic adenocarcinoma without neoadjuvant treatment were used to compare clinical and pathologic nodal staging. In SEER data, medium-term survival in stage IIB was superior to IB and IIA, with median cause-specific survival of 14, 9, and 11 months, respectively (P < .001). Seventy-two percent of stage IIB patients underwent resection vs 28% in IB and 36% in IIA (P < .001). In our institutional data, 12.4% of patients had clinical evidence of nodal involvement vs 69.5% by pathologic staging (P < .001). Among clinical stage IA-IIA patients, 71.6% had nodal involvement by pathologic staging. Both SEER and institutional data support substantial underestimation of nodal involvement by clinical staging. This finding has implications in decisions regarding neoadjuvant therapy and analysis of outcomes in the absence of pathologic staging. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Gene expression profiles in stages II and III colon cancers

    DEFF Research Database (Denmark)

    Thorsteinsson, Morten; Kirkeby, Lene T; Hansen, Raino

    2012-01-01

    were retrieved from the Gene Expression Omnibus (GEO) (n¿=¿111) in addition to a Danish data set (n¿=¿37). All patients had stages II and III colon cancers. A Prediction Analysis of Microarray classifier, based on the 128-gene signature and the original training set of stage I (n¿=¿65) and stage IV (n......¿=¿76) colon cancers, was reproduced. The stages II and III colon cancers were subsequently classified as either stage I-like (good prognosis) or stage IV-like (poor prognosis) and assessed by the 36 months cumulative incidence of relapse. RESULTS: In the GEO data set, results were reproducible in stage...... correctly predicted as stage IV-like, and the remaining patients were predicted as stage I-like and unclassifiable, respectively. Stage II patients could not be stratified. CONCLUSIONS: The 128-gene signature showed reproducibility in stage III colon cancer, but could not predict recurrence in stage II...

  20. Simulation and comparison of equilibrium and nonequilibrium stage ...

    African Journals Online (AJOL)

    In the present study, two distinctly different approaches are followed for modelling of reactive distillation column, the equilibrium stage model and the nonequilibrium stage model. These models are simulated with a computer code developed in the present study using MATLAB programming. In the equilibrium stage models, ...

  1. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology.

    Science.gov (United States)

    Glujovsky, Demián; Farquhar, Cindy; Quinteiro Retamar, Andrea Marta; Alvarez Sedo, Cristian Roberto; Blake, Deborah

    2016-06-30

    Advances in cell culture media have led to a shift in in vitro fertilisation (IVF) practice from cleavage stage embryo transfer to blastocyst stage transfer. The rationale for blastocyst transfer is to improve both uterine and embryonic synchronicity and enable self selection of viable embryos, thus resulting in better live birth rates. To determine whether blastocyst stage (day 5 to 6) embryo transfers improve the live birth rate, and other associated outcomes, compared with cleavage stage (day 2 to 3) embryo transfers. We searched the Cochrane Gynaecology and Fertility Group Specialised Register of controlled trials, Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library; 2016, Issue 4), MEDLINE, EMBASE, PsycINFO, CINAHL, and Bio extracts from inception to 4th April 2016. We also searched registers of ongoing trials and the reference lists of studies retrieved. We included randomised controlled trials (RCTs) which compared the effectiveness of blastocyst versus cleavage stage transfers. We used standard methodological procedures recommended by Cochrane. Our primary outcomes were live birth and cumulative clinical pregnancy rates. Secondary outcomes were clinical pregnancy, multiple pregnancy, high order pregnancy, miscarriage, failure to transfer embryos, and embryo freezing. We assessed the overall quality of the evidence for the main comparisons using GRADE methods. We included 27 RCTs (4031 couples or women).The live birth rate following fresh transfer was higher in the blastocyst transfer group (odds ratio (OR) 1.48, 95% confidence interval (CI) 1.20 to 1.82; 13 RCTs, 1630 women, I(2) = 45%, low quality evidence) following fresh transfer. This suggests that if 29% of women achieve live birth after fresh cleavage stage transfer, between 32% and 42% would do so after fresh blastocyst stage transfer.There was no evidence of a difference between the groups in rates per couple of cumulative pregnancy following fresh and frozen

  2. The Analysis, Optimization, and Simulation of a Two-Stage Tandem Queueing Model with Hyperexponential Service Time at Second Stage

    Directory of Open Access Journals (Sweden)

    Vedat Sağlam

    2015-01-01

    Full Text Available The aim of this paper is to analyze a tandem queueing model with two stages. The arrivals to the first stage are Poisson stream and the service time at this stage is exponential. There is no waiting room at first stage. The service time is hyperexponential and no waiting is allowed at second stage. The transition probabilities and loss probabilities of this model are obtained. In addition, the loss probability at second stage is optimized. Performance measures and the variance of the numbers of customers of this tandem queueing model are found. It is seen that the numbers of customers in first stage and second stage are dependent. Finally we have simulated this queueing model. For different values of parameters, exact values, simulated values, and optimal values of obtained performance measures of this model are numerically shown in tables and graphs.

  3. Evaluation of the I. Stage of decommissioning and implementation of the II. Stage of decommissioning of NPP V1

    International Nuclear Information System (INIS)

    Hrasnova, E.

    2015-01-01

    In this paper author deals with following aspects: 1. Introduction of company Nuclear and Decommissioning Company, plc; 2. Evaluation of the I. stage of decommissioning and implementation of the II. Stage of decommissioning of NPP V1; (author)

  4. Cross-stage immunity for malaria vaccine development.

    Science.gov (United States)

    Nahrendorf, Wiebke; Scholzen, Anja; Sauerwein, Robert W; Langhorne, Jean

    2015-12-22

    A vaccine against malaria is urgently needed for control and eventual eradication. Different approaches are pursued to induce either sterile immunity directed against pre-erythrocytic parasites or to mimic naturally acquired immunity by controlling blood-stage parasite densities and disease severity. Pre-erythrocytic and blood-stage malaria vaccines are often seen as opposing tactics, but it is likely that they have to be combined into a multi-stage malaria vaccine to be optimally safe and effective. Since many antigenic targets are shared between liver- and blood-stage parasites, malaria vaccines have the potential to elicit cross-stage protection with immune mechanisms against both stages complementing and enhancing each other. Here we discuss evidence from pre-erythrocytic and blood-stage subunit and whole parasite vaccination approaches that show that protection against malaria is not necessarily stage-specific. Parasites arresting at late liver-stages especially, can induce powerful blood-stage immunity, and similarly exposure to blood-stage parasites can afford pre-erythrocytic immunity. The incorporation of a blood-stage component into a multi-stage malaria vaccine would hence not only combat breakthrough infections in the blood should the pre-erythrocytic component fail to induce sterile protection, but would also actively enhance the pre-erythrocytic potency of this vaccine. We therefore advocate that future studies should concentrate on the identification of cross-stage protective malaria antigens, which can empower multi-stage malaria vaccine development. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  5. ROLE OF MRI IN STAGING OF CARCINOMA CERVIX

    Directory of Open Access Journals (Sweden)

    Jaipal R

    2016-03-01

    Full Text Available CONTEXT Cervical carcinoma continues to be staged according to the clinical FIGO classification system which is not accurate. In our study, we determined the diagnostic accuracy of MRI in staging carcinoma cervix with same parameters as FIGO staging. AIMS In our study, we determined the diagnostic accuracy of MRI in staging carcinoma cervix, adjoining organ infiltration and delineating stage IIA and below from rest of the stages in carcinoma cervix. SETTINGS Study was done in the Department of Radiodiagnosis, in a tertiary care government hospital on 70 female patients diagnosed with carcinoma cervix. DESIGN Hospital based observational study. MATERIALS AND METHODS MRI staging was correlated with surgico-pathological findings when patient underwent surgery. MRI staging was compared to the non-pathological staging when patient underwent radiotherapy or neoadjuvant chemotherapy. STATISTICAL ANALYSIS Univariate and bivariate frequency tables are generated. Sensitivity, specificity and accuracy of MRI in staging of carcinoma cervix are calculated. Interclass correlation is done with Pearson’s correlation co-efficient, p value ≤ 0.05 was considered statistically significant. RESULTS MRI has a sensitivity, specificity, PPV, NPV and accuracy of 88.7%, 87.5%, 98.2%, 50% and 88.6% respectively [with interclass correlation coefficient r=0.982, p<0.01 95% CI (0.972 –0.989] in staging of carcinoma cervix. CONCLUSIONS MRI in staging carcinoma cervix is preferred to clinical FIGO staging for deciding on the treatment modality. However, MRI is not a good modality in detecting carcinoma in situ [stage 0] and stage I of carcinoma cervix.

  6. Improved clinical staging of esophageal cancer with FDG-PET

    International Nuclear Information System (INIS)

    Kim, Young Hwan; Choi, Joon Young; Lee, Kyung Soo; Choi, Yong Soo; Lee, Eun Jeong; Chung, Hyun Woo; Lee, Su Jin; Lee, Kyung Han; Shim, Young Mog; Kim, Byung Tae

    2004-01-01

    Since preoperative staging in esophageal cancer is important in both therapy and prognosis, there had been many efforts to improve its accuracy. Recent studies indicate that whole body FDG-PET has high sensitivity in detection of metastasis in esophageal cancer. Therefore, we added FDG-PET to other conventional methods in staging esophageal cancer to evaluate the usefulness of this method. Subjects were 142 esophageal cancer patients (average 62.3±8.3 yrs) who received CT and PET just before operation. First, we compared N stage and M stage of the CT or PET with those of the post-operative results. Then we compared the stage according to the EUS (T stage) and CT (N and M stage) or EUS (T stage) and CT and PET (N and M stage) to that according to the post-operative results. Among 142 patients, surgical staging of 69 were N0 and 73 were N1. In M staging, 128 were M0 and 14 were M1. Sensitivity, specificity, and accuracy of N staging were 35.6%, 89.9%, 62.0% with CT and 58.9%, 71.0%, 64.7% with PET, respectively. In M staging, 14.3%, 96.9%, 88.7% with CT and 50.0%, 94.5%, 90.1% with PET, respectively. The concordances of [EUS+CT] and [EUS+CT+PET] with post-operative results were 41.2% and 54.6%, respectively and there was significant improvement of staging with additional PET scan (p<0.005). The concordance of [EUS+CT+PET] with post-operative result was significantly increased compared to that of [EUS+CT]. Thus, the addition of FDG-PET with other conventional methods may enable more accurate preoperative staging

  7. Structural analysis at aircraft conceptual design stage

    Science.gov (United States)

    Mansouri, Reza

    . Considering the strength and limitations of both methodologies, the question to be answered in this thesis is: How valuable and compatible are the classical analytical methods in today's conceptual design environment? And can these methods complement each other? To answer these questions, this thesis investigates the pros and cons of classical analytical structural analysis methods during the conceptual design stage through the following objectives: Illustrate structural design methodology of these methods within the framework of Aerospace Vehicle Design (AVD) lab's design lifecycle. Demonstrate the effectiveness of moment distribution method through four case studies. This will be done by considering and evaluating the strength and limitation of these methods. In order to objectively quantify the limitation and capabilities of the analytical method at the conceptual design stage, each case study becomes more complex than the one before.

  8. Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer

    Science.gov (United States)

    2018-01-12

    Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Salivary Gland Squamous Cell Carcinoma; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  9. Uterine cervical cancer. Preoperative staging with magnetic resonance imaging; Zervixkarzinom. Praeoperatives Staging mittels Magnetresonanztomographie

    Energy Technology Data Exchange (ETDEWEB)

    Collettini, F.; Hamm, B. [Charite-Universitaetsmedizin Berlin, Campus Charite Mitte, Klinik fuer Radiologie, Berlin (Germany)

    2011-07-15

    The treatment of uterine cervical carcinoma is largely dependent on the tumor stage. Despite significant inaccuracies in the clinical examination, uterine cervical cancer remains the only gynecological form of cancer still largely staged according to clinical findings. Although imaging is still not included in the staging the recently published revised FIGO (Federation International de Gynecologie et d'Obstetrique) system encourages the use of modern cross-sectional imaging (magnetic resonance imaging MRI and computed tomography CT). Due to its high soft tissue contrast MRI allows excellent non-invasive assessment of the cervix with direct tumor delineation as well as assessment of the prognosis based on morphological factors. Studies in the literature report an accuracy of 93% for MRI in the preoperative assessment of tumor size and in the differentiation of operable from advanced cervical cancer. Therefore MRI is considered to be the optimal modality for diagnostic evaluation starting from FIGO stage IB1, for radiation therapy planning, and for exclusion of recurrence in follow-up. In this paper we give an overview of the role of magnetic resonance imaging in preoperative staging of uterine cervical cancer. (orig.) [German] Die Therapieplanung beim Zervixkarzinom ist weitgehend von der Stadieneinteilung nach FIGO (Federation International de Gynecologie et d'Obstetrique) abhaengig, die trotz erheblicher Ungenauigkeiten bei der klinischen Stadieneinteilung weiterhin aufgrund klinischer Untersuchungsbefunde erfolgt. Obwohl bildgebende Verfahren nach wie vor fuer die Stadieneinteilung nicht vorgesehen sind, wird im kuerzlich erschienen revidierten Stagingsystem der FIGO zum ersten Mal die Verwendung moderner Schnittbilddiagnostik (MRT und CT) befuerwortet. Die MRT ermoeglicht dank ihres hohen Weichteilkontrasts ein ausgezeichnetes nichtinvasives Staging des Zervixkarzinoms mit direkter Tumordarstellung sowie einer Prognoseabschaetzung anhand

  10. Rapid Two-stage Versus One-stage Surgical Repair of Interrupted Aortic Arch with Ventricular Septal Defect in Neonates

    Directory of Open Access Journals (Sweden)

    Meng-Lin Lee

    2008-11-01

    Conclusion: The outcome of rapid two-stage repair is comparable to that of one-stage repair. Rapid two-stage repair has the advantages of significantly shorter cardiopulmonary bypass duration and AXC time, and avoids deep hypothermic circulatory arrest. LVOTO remains an unresolved issue, and postoperative aortic arch restenosis can be dilated effectively by percutaneous balloon angioplasty.

  11. Stages in the Formation of the Romanian Mental Space

    Directory of Open Access Journals (Sweden)

    POMPEI COCEAN

    2008-01-01

    Full Text Available In the evolution of the Romanian mental space, four distinct stages can be emphasized, each of them bringing its specific contribution to its defining and structuring. These stages are the following: the forerunning, Dacian stage, the 2nd century B.C. - 106 A.D.; the incipient, Dacian-Roman stage, 105 – 275 A.D.; the structuring, proto-Romanian stage, 275 – the 6th and 7th centuries; the Romanian stage of completion and affirmation, the 8th century – nowadays. Each stage is characterized by different forms, in continuous affirmation and improvement, of interrelations between the human communities and the site, of spiritually sublimation of the physical-geographical substratum features, of the territory inhabited by them.

  12. A two stage data envelopment analysis model with undesirable output

    Science.gov (United States)

    Shariff Adli Aminuddin, Adam; Izzati Jaini, Nur; Mat Kasim, Maznah; Nawawi, Mohd Kamal Mohd

    2017-09-01

    The dependent relationship among the decision making units (DMU) is usually assumed to be non-existent in the development of Data Envelopment Analysis (DEA) model. The dependency can be represented by the multi-stage DEA model, where the outputs from the precedent stage will be the inputs for the latter stage. The multi-stage DEA model evaluate both the efficiency score for each stages and the overall efficiency of the whole process. The existing multi stage DEA models do not focus on the integration with the undesirable output, in which the higher input will generate lower output unlike the normal desirable output. This research attempts to address the inclusion of such undesirable output and investigate the theoretical implication and potential application towards the development of multi-stage DEA model.

  13. Augment-type two stage accelerator

    International Nuclear Information System (INIS)

    Ogino, Mutsuo; Azuma, Kingo.

    1995-01-01

    When a flying body accelerated by a gas gun at a first stage enters into an augment rail passing through an introduction tube, an ignition capacitor for initial plasmas is turned ON to apply a voltage between the augment rails. Subsequently, the accelerating gas present behind the flying body is formed into plasmas by a laser, to flow electric current from one of the inner augment rails → plasma armature → the other of the inner augment rails, and additionally accelerate the flying body by Lorentz force formed in this case. Since the plasmas are maintained in a state of higher density than the plasmas obtained by using all of the augment rails, the ignition capacitor for initial plasmas in switched to a power source. As a result, it is possible to flow the maximum current before the plasmas expand, and a large accelerating force and a high magnetic flux density are attained, to improve acceleration performance of the flying body. (N.H.)

  14. Why geodiversity matters in valuing nature's stage.

    Science.gov (United States)

    Hjort, Jan; Gordon, John E; Gray, Murray; Hunter, Malcolm L

    2015-06-01

    Geodiversity--the variability of Earth's surface materials, forms, and physical processes-is an integral part of nature and crucial for sustaining ecosystems and their services. It provides the substrates, landform mosaics, and dynamic physical processes for habitat development and maintenance. By determining the heterogeneity of the physical environment in conjunction with climate interactions, geodiversity has a crucial influence on biodiversity across a wide range of scales. From a literature review, we identified the diverse values of geodiversity; examined examples of the dependencies of biodiversity on geodiversity at a site-specific scale (for geosites <1 km(2) in area); and evaluated various human-induced threats to geosites and geodiversity. We found that geosites are important to biodiversity because they often support rare or unique biota adapted to distinctive environmental conditions or create a diversity of microenvironments that enhance species richness. Conservation of geodiversity in the face of a range of threats is critical both for effective management of nature's stage and for its own particular values. This requires approaches to nature conservation that integrate climate, biodiversity, and geodiversity at all spatial scales. © 2015 Society for Conservation Biology.

  15. Five stages in a practical population policy.

    Science.gov (United States)

    Taylor, C E

    1968-12-01

    A systematic approach to population planning is presented. This should help to provide a basis for decision-making about emphases and priorities. The greatest force for change is the increasing world population. The sharpest controversy is between proponents of family planning, who try to make it possible for parents to have the number of children they want, and proponents of population control, who try to modify the environment so parents will want fewer children. The five developmental stages in the organization of programs are: 1) to meet the existing demand and tell women where to go for birth limitation help; 2) to provide good quality technical service, organization, and follow-up because satisfied users are the best recruiters while unsatisfied persons can produce unfavorable rumors; 3) to improve family planning motivation by caring for the health of mothers and children particularly when high infant mortality must be corrected, (the post-partum period is thought to be the best time to educate mothers); 4) to alter the family's view of its economic prospects and its understanding of financial implications of more children, particularly in underdeveloped countries; 5) to modify socio-cultural factors, such as delayed age at marriage, more education of women, and general discussions of traditional beliefs. Population policy requires long-range planning with phased action.

  16. LENS: Science Scope and Development Stages

    Science.gov (United States)

    Vogelaar, R. Bruce

    2013-04-01

    The Low-Energy Neutrino Spectroscopy (LENS) experiment will resolve the solar metallicity question via measurement of the CNO neutrino flux, as well as test the predicted equivalence of solar luminosity as measured by photon versus neutrinos. The LENS detector uses charged-current interaction of neutrinos on Indium-115 (loaded in a scintillator, InLS) to reveal the complete solar neutrino spectrum. LENS's optically segmented 3D lattice geometry achieves precise time and spatial resolution and unprecedented background rejection and sensitivity for low-energy neutrino events. This first-of-a-kind lattice design is also suited for a range of other applications where high segmentation and large light collection are required (eg: sterile neutrinos with sources, double beta decay, and surface detection of reactor neutrinos). The physics scope, detector design, and logic driving the microLENS and miniLENS prototyping stages will be presented. The collaboration is actively running programs; building, operating, developing, and simulating these prototypes using the Kimballton Underground Research Facility (KURF). New members are welcome to the LENS Collaboration, and interested parties should contact R. Bruce Vogelaar.

  17. STAGE OF TEXTILE RECYCLE WASTE IN ROMANIA

    Directory of Open Access Journals (Sweden)

    TRIPA Simona

    2014-05-01

    Full Text Available Aim of this article is to examine the stage of textile recycle waste in Romania. For this purpose were analyzed the main sources of textile waste from Romania (industry of manufacture of textiles, wearing apparel, leather and related products, imports of textiles, clothing and footwear and imports of second hand clothing and also evolution of the quantity of textile waste in Romania. The benefits (economic and environmental of the collection and recycling of waste and the legislation on the waste management, have determined the diversification and increasing the number and the capacity of recovery and disposal of waste in Romania. We found the most textile waste in Romania was deposited in deposits onto or into land, in the proportion of 18.51%. This proportion is under the EU average of 34.03%, but is much higher than in other European country. Also, has been an increase in the number of incinerators, in the last years. With all of this, the interest in textile waste management in Romania is far from being to the level of European, where are associations who dealing with the collection and recycling of textiles and is achieved a selective collection of textile waste in the points especially designed for this thing. The information for this paper was gathered from literature, from the EUROSTAT database and INSSE database analysis and by Internet.

  18. Baton twirling on an international stage

    CERN Document Server

    Stephanie McClellan

    2013-01-01

    There aren’t many people who can throw a baton in the air, do a backhand spring and catch it with the grace of a dancer. Well, Julie Haffner from the CERN Press Office can. Baton twirling started as her hobby but soon became a passion - leading her team to win the International Baton Twirling Cup.    Gex Twirling Club performing their winning number at the 2013 International Baton Twirling Cup. (Image: Véronique Bellour). There is no telling when or where people will find their passion. For Julie Haffner, it was when she followed her cousin to a baton twirling class at the age of 10. Since that fortuitous day, she has committed herself to the sport and competed on international stages. Very close to rhythmic gymnastics, baton twirling requires skilful coordination and teamwork. Julie’s performances combine the precision of baton manipulation, the grace of a dancer and the strength of a gymnast. The first year in which she competed with the Gex Twirlin...

  19. Three-stage linear, split-Stirling cryocooler for 1 to 2K magnetic cold stage

    International Nuclear Information System (INIS)

    Longsworth, R.C.

    1993-08-01

    A long-life, linear, high efficiency 8K split Stirling cycle cryocooler was designed, built, and tested. The refrigerator is designed for cooling a 50 mW, 1.5K magnetic cold stage. Dual opposed piston compressors are driven by moving-coil linear motors. The three stage expander, although not completed, is also driven by a linear motor and is designed to produce 1 SW at 60K, 4W at 16K, and 1.2W at 8K. The cold regenerator employs a parallel gap construction for high efficiency. The key technology areas addressed include warm and cold flexible suspension bearings and a new cold regenerator geometry for high efficiency at 8K

  20. An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites.

    Science.gov (United States)

    Absalon, Sabrina; Robbins, Jonathan A; Dvorin, Jeffrey D

    2016-04-28

    Blood-stage replication of the human malaria parasite Plasmodium falciparum occurs via schizogony, wherein daughter parasites are formed by a specialized cytokinesis known as segmentation. Here we identify a parasite protein, which we name P. falciparum Merozoite Organizing Protein (PfMOP), as essential for cytokinesis of blood-stage parasites. We show that, following PfMOP knockdown, parasites undergo incomplete segmentation resulting in a residual agglomerate of partially divided cells. While organelles develop normally, the structural scaffold of daughter parasites, the inner membrane complex (IMC), fails to form in this agglomerate causing flawed segmentation. In PfMOP-deficient gametocytes, the IMC formation defect causes maturation arrest with aberrant morphology and death. Our results provide insight into the mechanisms of replication and maturation of malaria parasites.

  1. A new system for assessment of growth using mandibular canine calcification stages and its correlation with modified MP3 stages

    Directory of Open Access Journals (Sweden)

    Gautham Hegde

    2014-01-01

    Full Text Available Objective: Orthodontic diagnosis and treatment planning for growing children must involve growth prediction, especially in the treatment of skeletal problems. Studies have shown that a strong association exists between skeletal maturity and dental calcification stages. The present study was therefore taken up to provide a simple and practical method for assessing skeletal maturity using a dental periapical film and standard dental X-ray machine, to compare the developmental stages of the mandibular canine with that of developmental stages of modified MP3 and to find out if any correlation exists, to determine if the developmental stages of the mandibular canine alone can be used as a reliable indicator for assessment of skeletal maturity. Materials and Methods: A total of 160 periapical radiographs, of the mandibular right canine and the MP3 region was taken and assessed according to the Dermirjian′s stages of dental calcification and the modified MP3 stages. Results and Discussion: The correlation coefficient between MP3 stages and developmental stages of mandibular canine was found to be significant in both male and female groups. When the canine calcification stages were compared with the MP3 stages it was found that with the exception of the D stage of canine calcification the remaining stages showed a very high correlation with the modified MP3 stages. Conclusion: The correlation between the mandibular canine calcification stages, and the MP3 stages was found to be significant. The canine calcification could be used as a sole indicator for assessment of skeletal maturity.

  2. Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.

    Directory of Open Access Journals (Sweden)

    Brandon K Sack

    2015-05-01

    Full Text Available Malaria, caused by Plasmodium parasite infection, continues to be one of the leading causes of worldwide morbidity and mortality. Development of an effective vaccine has been encumbered by the complex life cycle of the parasite that has distinct pre-erythrocytic and erythrocytic stages of infection in the mammalian host. Historically, malaria vaccine development efforts have targeted each stage in isolation. An ideal vaccine, however, would target multiple life cycle stages with multiple arms of the immune system and be capable of eliminating initial infection in the liver, the subsequent blood stage infection, and would prevent further parasite transmission. We have previously shown that immunization of mice with Plasmodium yoelii genetically attenuated parasites (GAP that arrest late in liver stage development elicits stage-transcending protection against both a sporozoite challenge and a direct blood stage challenge. Here, we show that this immunization strategy engenders both T- and B-cell responses that are essential for stage-transcending protection, but the relative importance of each is determined by the host genetic background. Furthermore, potent anti-blood stage antibodies elicited after GAP immunization rely heavily on FC-mediated functions including complement fixation and FC receptor binding. These protective antibodies recognize the merozoite surface but do not appear to recognize the immunodominant merozoite surface protein-1. The antigen(s targeted by stage-transcending immunity are present in both the late liver stages and blood stage parasites. The data clearly show that GAP-engendered protective immune responses can target shared antigens of pre-erythrocytic and erythrocytic parasite life cycle stages. As such, this model constitutes a powerful tool to identify novel, protective and stage-transcending T and B cell targets for incorporation into a multi-stage subunit vaccine.

  3. Computational study of the first stage of hypersonic ion beam neutralization: The cross neutralization stage

    International Nuclear Information System (INIS)

    Pomot, C.; Dolique, J.M.

    1975-01-01

    A study is made of the first stage of evolution of a hypersonic ion beam in which thermoelectrons are emitted by a heated grid, known as the neutralizer. Downstream from the neutralizer there appears successively as a sheath a range of periodic and quasi-stationary electric field and a front where the electric field oscillates with the plasma frequency. The sheath is self-regulated. Some electrons are trapped in the periodic and stationary electric field. The characteristics of the periodic, quasi-stationary range correspond to those of both an experimental study and one-dimensional time-independent macroscopic theory. This quasi-stationary regime builds up in a time smaller than ω/subp/e -1 and is studied for a few periods ω/subP//sube/ -1 . The subsequent evolution of this state of nonequilibrium is not investigated. The experimental study has shown that, as for the neutralization of a subsonic ion beam, it leads to a field-free, homogeneous medium: a ''synthesized plasma.'' The importance of the first stage described herein, which may be called the gross neutralization stage, is due to the properties of mean neutrality in the current and in the charge insured by the regulating sheath, properties which will be preseved downstream

  4. One-stage vs two-stage cartilage repair: a current review

    Directory of Open Access Journals (Sweden)

    Daniel Meyerkort

    2010-10-01

    Full Text Available Daniel Meyerkort, David Wood, Ming-Hao ZhengCenter for Orthopaedic Research, School of Surgery and Pathology, University of Western Australia, Perth, AustraliaIntroduction: Articular cartilage has a poor capacity for regeneration if damaged. Various methods have been used to restore the articular surface, improve pain, function, and slow progression to osteoarthritis.Method: A PubMed review was performed on 18 March, 2010. Search terms included “autologous chondrocyte implantation (ACI” and “microfracture” or “mosaicplasty”. The aim of this review was to determine if 1-stage or 2-stage procedures for cartilage repair produced different functional outcomes.Results: The main procedures currently used are ACI and microfracture. Both first-generation ACI and microfracture result in clinical and functional improvement with no significant differences. A significant increase in functional outcome has been observed in second-generation procedures such as Hyalograft C, matrix-induced ACI, and ChondroCelect compared with microfracture. ACI results in a higher percentage of patients with clinical improvement than mosaicplasty; however, these results may take longer to achieve.Conclusion: Clinical and functional improvements have been demonstrated with ACI, microfracture, mosaicplasty, and synthetic cartilage constructs. Heterogeneous products and lack of good-quality randomized-control trials make product comparison difficult. Future developments involve scaffolds, gene therapy, growth factors, and stem cells to create a single-stage procedure that results in hyaline articular cartilage.Keywords: autologous chondrocyte implantation, microfracture, cartilage repair

  5. Predation on transmission stages reduces parasitism: sea anemones consume transmission stages of a barnacle parasite.

    Science.gov (United States)

    Fong, Caitlin R; Kuris, Armand M

    2017-06-01

    While parasites serve as prey, it is unclear how the spatial distribution of parasite predators provides transmission control and influences patterns of parasitism. Because many of its organisms are sessile, the rocky intertidal zone is a valuable but little used system to understand spatial patterns of parasitism and elucidate the underlying mechanisms driving these patterns. Sea anemones and barnacles are important space competitors in the rocky intertidal zone along the Pacific coast of North America. Anemones are voracious, indiscriminate predators; thus, they may intercept infectious stages of parasites before they reach a host. We investigate whether a sea anemone protects an associated barnacle from parasitism by Hemioniscus balani, an isopod parasitic castrator. At Coal Oil Point, Santa Barbara, California USA, 29% of barnacles were within 1 cm from an anemone at the surveyed tidal height. Barnacles associated with anemones had reduced parasite prevalence and higher reproductive productivity than those remote from sea anemones. In the laboratory, anemones readily consumed the transmission stage of the parasite. Hence, anemone consumption of parasite transmission stages may provide a mechanism by which community context regulates parasite prevalence at a local scale. Our results suggest predation may be an important process providing parasite transmission control.

  6. Preliminary design of the repository. Stage 2

    International Nuclear Information System (INIS)

    Saanio, T.; Kirkkomaeki, T.; Keto, P.; Kukkola, T.; Raiko, H.

    2007-04-01

    Spent nuclear fuel from Finnish nuclear power plants will be disposed of in deep bedrock in Olkiluoto, Eurajoki. The repository is planned to be excavated at a depth of 400 - 500 metres. Access routes to the repository include a 1:10 inclined access tunnel, and vertical shafts. The fuel is encapsulated in the encapsulation plant above ground and transferred to the repository in the canister lift. Deposition tunnels, central tunnels and technical rooms are excavated at the disposal level. The canisters are deposited in deposition holes that are covered with bentonite blocks. The deposition holes are bored in the floors of the deposition tunnels. The central tunnel system consists of two parallel central tunnels that are inter-connected at certain distances. Two parallel central tunnels improve the fire safety of the rooms and also allow flexible backfilling and closing of the deposition tunnels in stages at the operational phase of the repository. An underground rock characterization facility, ONKALO, is excavated at the disposal level to support and confirm investigations carried out from above ground. ONKALO is designed so that it can later serve as part of the repository. ONKALO excavations were started in 2004. The repository will be excavated in the 2010s and operation will start in 2020. The fifth nuclear power unit makes the operational phase of the repository very long. Parts of the repository will be excavated and closed over the long operational period. The repository can be constructed at one or several levels. The one-storey alternative is the so-called reference alternative in this preliminary design report. The two-storey alternative is also taken into account in the ONKALO designs. The preliminary designs of the repository are presented as located in Olkiluoto. The location of the repository will be revised when more information on the bedrock has been gained. More detailed data of the circumstances will be obtained from above ground investigations

  7. Omicron space habitat—research stage II

    Science.gov (United States)

    Doule, Ondřej; Šálený, Vratislav; Hérin, Benoît; Rousek, Tomáš

    2012-01-01

    The design presented in this paper is in response to the revolution in private space activities, the increasing public interest in commercial flights to space and the utilization of structures such as space hotels or private orbital habitats. The baseline for the Omicron design concept is the Russian Salyut derived space station module. Salyut was the first space station to orbit the Earth. Its unique design and technical features were what made the development of space stations Salyut 1-7, MIR and the International Space Station (ISS) Zwezda service module possible. Due to its versatility and the reliable operating launch vehicle Proton, this space module series has the potential to be adapted for space hotel development. This paper proposes a conceptual design of the space habitat called Omicron, with particular focus on interior design for the microgravity environment. The Omicron concepts address the needs of space tourism with a strong emphasis on the safety and comfort of the spaceflight participants. The Omicron habitat supports three inhabitants in nominal conditions (e.g., two passengers and one astronaut). The habitat provides a flexible interior, facilities and spaces dynamically transforming in order to accommodate various types of activities, which will be performed in an organically formed interior supporting spatial orientation and movement in microgravity. The future development potential of Omicron is also considered. The baseline version is composed solely of one rigid module with an inverted cupola for observations. An alternative version offers more space using an inflatable structure. Finally, a combination of multiple Omicron modules enables the creation of a larger orbital habitat. The Omicron's subsystems support a few days visit by trained passengers. The transport to the habitat would be provided e.g., by the Soyuz TMA spacecraft carried by the Soyuz launch vehicle in the early stage of Omicron's development, before a fully reusable

  8. Nephrolithiasis-induced end stage renal disease

    Science.gov (United States)

    Ounissi, M; Gargueh, T; Mahfoudhi, M; Boubaker, K; Hedri, H; Goucha, R; Abderrahim, E; Ben Hamida, F; Ben Abdallah, T; El Younsi, F; Ben Maiz, H; Kheder, A

    2010-01-01

    Introduction: Nephrolithiasis still remains a too frequent and underappreciated cause of end stage renal disease (ESRD). Methods and patients: Of the entire cohort of 7128 consecutive patients who started maintenance dialysis in our nephrology department between January 1992 and December 2006, a total of 45 patients (26 women, 19 men) had renal stone disease as the cause of ESRD. The type of nephrolithiasis was determined in 45 cases and etiology in 42. The treatment and evolution of stone disease and patient’s survival were studied. Results: The overall proportion of nephrolithiasis related ESRD was 0.63%. The mean age was 48.4 years. Infection stones (struvite) accounted for 40%, calcium stones, 26.67% (primary hyperparathyroidism:15.56%; familial hypercalciuria: 4.44%, unknown etiology: 6.66%), primary hyperoxaluria type 1, 17.78% and uric acid lithiasis in 15.56% of cases. The mean delay of the evolution of the stone renal disease to chronic renal failure was 85.8 months. The feminine gender, obesity and elevated alkaline phosphatases >128 IU/L were significantly correlated with fast evolution of ESRD. The median evolution to ESRD was 12 months. The normal body mass index (BMI), medical treatment of stone and primary hyperoxaluria type 1 were correlated with fast evolution to ESRD. All patients were treated by hemodialysis during a mean evolution of 60 months. Sixteen patients died. The patient's survival rate at 1, 3 and 5 years was 97.6, 92.8 and 69% respectively. Hypocalcemia, cardiopathy and normal calcium-phosphate product were significantly correlated with lower survival rate. Conclusion: Severe forms of nephrolithiasis remain an underestimated cause of ESRD. These findings highlight the crucial importance of accurate stone analysis and metabolic evaluation to provide early diagnosis and efficient treatment for conditions leading to ESRD. PMID:21694924

  9. Global warming-setting the stages

    International Nuclear Information System (INIS)

    1994-01-01

    Most of us have heard or read about global warming. However, the messages we receive are often in conflict, raising more questions than answer. Is global warming a good or a bad thing? has it already started or is it part of our future? Are we, or are we not doing anything about it? Should we be concerned? This primer on Global Warming is designed to clear up some of this confusion by providing basic scientific information on global warming issue. It is clear that there is still much to learn about global warming. However, it is also clear that there is a lot that we already know - and that dose provide cause for concern. We must understand the global warming issue if we are to make wise decisions and take responsible actions in response to the challenges and opportunities posed by global warming. Chapter 1 of 'the primer on global Warming' set the stage with a brief overview of science of global warming within the context of climate change. In addition, it introduces the specific issues that surround the global warming problem. As far as the science of global warming is concerned the following questions are discussed. What is global climate? Is climate change natural? What causes climate to vary on a global scale? How does the composition of the atmosphere relate to climate change. but there are also certain issues discussed here which surround the global warming such as: If climate varies naturally, why is there a concern about 'global warming'? What are the potential consequences of 'global warning'. What human activities contribute to 'global warming'. (Author)

  10. Towards individualised radiotherapy for Stage I seminoma

    International Nuclear Information System (INIS)

    Martin, Jarad M.; Joon, Daryl Lim; Ng, Nicole; Grace, Michael; Gelderen, David van; Lawlor, Marita; Wada, Morikatsu; Joon, Michael Lim; Quong, George; Khoo, Vincent

    2005-01-01

    Background and purpose: Adjuvant radiotherapy is currently standard treatment of Stage I seminoma (SOS). The use of computerised tomogram (CT) planning is compared with traditional planning for greater treatment individualisation. Material and methods: Two plans were generated for each of 10 patients: one using traditional rectangular para-aortic fields, and one using conformal fields. The primary target volume compared was the dosimetric coverage of the inferior vena cava and aorta. Results: The dosimetric analysis of traditional plans showed that they provided reasonable dosimetric coverage of the CTV. However, if 1 cm is used for uncertainty based on nodal coverage then the periphery of the PTV could be significantly under-dosed. The CT based plan delivered improved dosimetry to the vessel PTV compared with the traditional field (CT D95=24.7 Gy, traditional D95=23.6 Gy, P=0.002). CT-based plans were significantly wider than traditional plans (CT=11.8 cm, traditional=9 cm, P=0.002). The CT plan tended to irradiate relatively small volumes of the kidneys to higher doses. Conclusions: Traditional para-aortic fields may deliver suboptimal dosimetry to an anatomically defined PTV. Our CT-based fields tend to be wider than traditional fields, and provide improved dosimetry to vessels based target volumes. Given that traditional fields are often delivering significantly less than the prescribed dose to the target volume, and that marginal relapses cause a high proportion of treatment failure, there is a suggestion that CT-based plans may avoid underdosage and geographical miss sometimes seen with traditional plans

  11. Hemodynamic characteristics of early stage hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Kudo, Masatoshi; Tomita, Shusuke; Tochio, Hitoshi

    1992-01-01

    Hemodynamic characteristics were studied by using in vivo vascular imaging techniques in 17 resected early stage hepatocellular carcinoma (e-HCC) by comparing them with 49 resected advanced HCCs (ad-HCC) less than 3 cm in diameter. In this study, e-HCC was defined as the nodule being uniformly composed of well-differentiated HCC or adenomatous hyperplastic nodule containing well-differentiated HCC foci within the nodule. In vivo vascular imaging techniques are as follows; US angiography with intraarterial CO 2 microbubbles were performed to assess the tumor arterial vascularity, and CT during arterial portography (CTAP) was performed to assess the portal perfusion within the nodule. Of 17 e-HCC nodules 5 were hypervascular, 5 were isovascular, 4 were hypovascular, and 3 were vascular spot in hypovascular pattern in contrast to 49 ad-HCC nodules, 43 of which were hypervascular and 6 were isovascular. Of 14 e-HCCs, 9 nodules showed perfusion defect and 5 did not on CTAP, whereas all 37 ad-HCCs on which CTAP was performed, showed perfusion defect. Forty-one percent (7/17) of e-HCC showed fatty metamorphosis in contrast to 8% (4/49) of ad-HCC. In conclusion, hemodynamic characteristics of e-HCC are summarized as follows. (1) Arterial tumor neovascularization is relatively low. (2) Portal perfusion is present in some of e-HCC cases. (3) Hypoperfusion state both from arterial and portal supply is present in some of e-HCC cases. (4) Vascular spot in hypovascular pattern is characteristic arterial pattern in AH containing HCC foci. (5) Fatty metamorphosis may be related with hypoperfusion state of the nodule in e-HCC. (author)

  12. Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer

    Science.gov (United States)

    2017-11-15

    Stage I Breast Cancer; Stage I Colorectal Cancer AJCC v6 and v7; Stage I Prostate Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage II Colorectal Cancer AJCC v7; Stage II Prostate Cancer; Stage IIA Breast Cancer; Stage IIA Colorectal Cancer AJCC v7; Stage IIA Prostate Cancer; Stage IIB Breast Cancer; Stage IIB Colorectal Cancer AJCC v7; Stage IIB Prostate Cancer; Stage IIC Colorectal Cancer AJCC v7; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7

  13. Investigation of unsteady flow in axial turbine stage

    Directory of Open Access Journals (Sweden)

    Němec Martin

    2012-04-01

    Full Text Available The never ending process to increase the efficiency of turbine stages introduced an idea to create an axial turbine stage test rig as part of closed loop transonic wind tunnel at Vyzkumny a zkusebni letecky ustav (VZLU. Studying of unsteady flow field behaviours in turbine stages is nowadays essential in the development process. Therefore, the test rig was designed with focusing on possibility of detailed studying of unsteady flow fields in turbine stages. New methodologies and new instrumentations were developed at VZLU and successfully integrated to gain valuable information from experiments with turbine stages. Two different turbine stages were tested during the facility introduction process. The measurement of these two models demonstrated how flexible the test rig is. One of them was an enlarged model of small gas turbine stage. The other was scaled-down model of stage of intermediate-pressure steam turbine. The external characteristics of both models were acquired during experiments as well as the detailed unsteady flow field measurement. Turbine stages were tested in various regimes in order to check the capabilities of the facility, methodology and instrumentation together. The paper presents results of unsteady flow field investigation in the enlarged turbine stage with unshrouded rotor. The interaction of structures developed in a stator with the rotor flow field is depicted and the influence of turbine load on evolution of secondary flows in rotor is analysed.

  14. Four stages of a scientific discipline; four types of scientist.

    Science.gov (United States)

    Shneider, Alexander M

    2009-05-01

    In this article I propose the classification of the evolutionary stages that a scientific discipline evolves through and the type of scientists that are the most productive at each stage. I believe that each scientific discipline evolves sequentially through four stages. Scientists at stage one introduce new objects and phenomena as subject matter for a new scientific discipline. To do this they have to introduce a new language adequately describing the subject matter. At stage two, scientists develop a toolbox of methods and techniques for the new discipline. Owing to this advancement in methodology, the spectrum of objects and phenomena that fall into the realm of the new science are further understood at this stage. Most of the specific knowledge is generated at the third stage, at which the highest number of original research publications is generated. The majority of third-stage investigation is based on the initial application of new research methods to objects and/or phenomena. The purpose of the fourth stage is to maintain and pass on scientific knowledge generated during the first three stages. Groundbreaking new discoveries are not made at this stage. However, new ways to present scientific information are generated, and crucial revisions are often made of the role of the discipline within the constantly evolving scientific environment. The very nature of each stage determines the optimal psychological type and modus operandi of the scientist operating within it. Thus, it is not only the talent and devotion of scientists that determines whether they are capable of contributing substantially but, rather, whether they have the 'right type' of talent for the chosen scientific discipline at that time. Understanding the four different evolutionary stages of a scientific discipline might be instrumental for many scientists in optimizing their career path, in addition to being useful in assembling scientific teams, precluding conflicts and maximizing

  15. Reflectance spectroscopy for noninvasive evaluation of hair follicle stage

    Science.gov (United States)

    Liu, Caihua; Guan, Yue; Wang, Jianru; Zhong, Xiewei; Liu, Xiuli; Zhu, Dan

    2015-05-01

    Hair follicle offers an excellent model for systems biology and regenerative medicine. So far, the stages of hair follicle growth have been evaluated by histological examination. In this work, a noninvasive spectroscopy was proposed by measuring the diffuse reflectance of mouse skin and analyzing the melanin value. Results show that the skin diffuse reflectance was relatively high when hair follicles were at the telogen stage and at the beginning of the anagen stage, and decreased with the progression of the anagen stage. When the hair follicle entered into the catagen stage, the diffuse reflectance gradually increased. The changes in the melanin content of skin had contrary dynamics. Substages of the hair follicle cycle could be distinguished by comparing the changes in melanin value with the histological examination. This study provided a new method for noninvasive evaluation of the hair follicle stage, and should be valuable for basic and therapeutic investigations on hair regeneration.

  16. Preoperative staging of lung cancer with PET/CT

    DEFF Research Database (Denmark)

    Søgaard, Rikke; Fischer, Barbara Malene B; Mortensen, Jann

    2011-01-01

    PURPOSE: Positron emission tomography (PET)/CT has become a widely used technology for preoperative staging of non-small cell lung cancer (NSCLC). Two recent randomized controlled trials (RCT) have established its efficacy over conventional staging, but no studies have assessed its cost......-effectiveness. The objective of this study was to assess the cost-effectiveness of PET/CT as an adjunct to conventional workup for preoperative staging of NSCLC. METHODS: The study was conducted alongside an RCT in which 189 patients were allocated to conventional staging (n = 91) or conventional staging + PET/CT (n = 98...... perspective, the cost-effectiveness of PET/CT for staging NSCLC seems to depend on the willingness to pay in order to avoid a futile thoracotomy. However, given that four outliers in terms of extreme comorbidity were all randomized to the PET/CT arm, there is uncertainty about the conclusion. When hospital...

  17. Updated guidelines on the preoperative staging of thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hye Jung [Dept. of Radiology, Kyungpook National University Medical Center, Daegu (Korea, Republic of)

    2017-10-15

    Recent studies have provided prognostic information and recommendations for staging thyroid cancers that have changed the staging and management guidelines for the disease. Consequently, minimal extrathyroidal extension (ETE) was removed from the T3 stage classification in the eighth edition of the TNM staging system by the American Joint Committee on Cancer. New T categories have been subsequently added, including T3a, defined as a tumor >4 cm in its greatest dimension, limited to the thyroid gland, and T3b, defined as a tumor of any size with gross ETE invading only the strap muscles. In this article, the author reviews the changes in the TNM staging system for thyroid cancer, with an emphasis on ultrasonography in preoperative staging.

  18. Apparatus and methods for controlling electron microscope stages

    Science.gov (United States)

    Duden, Thomas

    2015-08-11

    Methods and apparatus for generating an image of a specimen with a microscope (e.g., TEM) are disclosed. In one aspect, the microscope may generally include a beam generator, a stage, a detector, and an image generator. A plurality of crystal parameters, which describe a plurality of properties of a crystal sample, are received. In a display associated with the microscope, an interactive control sphere based at least in part on the received crystal parameters and that is rotatable by a user to different sphere orientations is presented. The sphere includes a plurality of stage coordinates that correspond to a plurality of positions of the stage and a plurality of crystallographic pole coordinates that correspond to a plurality of polar orientations of the crystal sample. Movement of the sphere causes movement of the stage, wherein the stage coordinates move in conjunction with the crystallographic coordinates represented by pole positions so as to show a relationship between stage positions and the pole positions.

  19. Energy demand in Portuguese manufacturing: a two-stage model

    International Nuclear Information System (INIS)

    Borges, A.M.; Pereira, A.M.

    1992-01-01

    We use a two-stage model of factor demand to estimate the parameters determining energy demand in Portuguese manufacturing. In the first stage, a capital-labor-energy-materials framework is used to analyze the substitutability between energy as a whole and other factors of production. In the second stage, total energy demand is decomposed into oil, coal and electricity demands. The two stages are fully integrated since the energy composite used in the first stage and its price are obtained from the second stage energy sub-model. The estimates obtained indicate that energy demand in manufacturing responds significantly to price changes. In addition, estimation results suggest that there are important substitution possibilities among energy forms and between energy and other factors of production. The role of price changes in energy-demand forecasting, as well as in energy policy in general, is clearly established. (author)

  20. Embryonic effects of radiation on ICR mice depending developmental stages

    International Nuclear Information System (INIS)

    Gu, Yeun Hwa; Kusama, Tomoko; Kai, Michiaki

    1995-01-01

    The ICR pregnant mice were irradiated at 1.5Gy in every 6 hours in the period of organogenesis in order to classify the stage specificity of the embryonic effects of radiation and the stage of development differentiation of the primordium of each major organ. Intrauterine death, fetal body weight and external malformation in live fetuses were observed on day 18 of gestation. There was no statistically significant difference in the intrauterine mortality at any stage organogenesis. The fetal body weight of the mice irradiated in the intermediate stage of organogenesis showed significantly lower. There were specific highly sensitive stages in the incidences of each external malformation, that is exencephalia, open eyelid, cleft palate, anomalies of extremities and anomalies of the tail. At these stage, the primordial of the major organs are established in ICR mice