WorldWideScience

Sample records for stage performance status

  1. Poor performance status, urban residence and female sex predict inferior survival in pediatric advanced stage mature B-NHL in an Indian tertiary care center.

    Science.gov (United States)

    Patel, Amol; Sharma, Meher Chand; Mallick, Saumyaranjan; Patel, Manali; Bakhshi, Sameer

    2018-02-01

    Advanced stage is a known prognostic factor in B-Non-Hodgkin Lymphoma (NHL); however, factors within advanced stage and overall data on pediatric B-NHL from India are lacking. This is a retrospective study wherein all consecutive pediatric (≤18 years) patients of advanced stage B-NHL (St. Jude stage 3 and 4) treated at our center from Jan 2003 to June 2016 with BFM-90 protocol were evaluated for outcome and pathology review. Total 140 patients were analyzed with median age 8 years; M:F ratio was 5.2:1; 36% patients presented within 30 days of symptom onset and 58% had rural residence. Burkitt lymphoma (66%) was commonest histopathological subtype; bone marrow was involved in 15% and CSF in 8% cases. Undernourishment was observed in 30% patients and 51% had ECOG performance status of 3&4. At 5 years, EFS was 52 ± 4% (CI 0.43-0.60) and OS was 61 ± 4% (CI 0.52-0.68). On multivariate analysis, poor performance status (p residence (p = 0.016) emerged as significant negative prognostic factors for EFS; while for OS, female sex (p = 0.006), poor performance status (p residence (p = 0.023) predicted inferior outcome. This is the largest study from south Asia on advanced stage pediatric B-NHL and it suggests undernourishment, poor performance status and gender bias to be unique features at presentation. Although, outcomes are comparable with other data from resource-challenged nations, yet they are 15-20% inferior than trial data from other developed countries. Further, poor performance status, female sex and urban residence for poor outcome were identified as unique prognostic factors.

  2. LIL laser performance status

    International Nuclear Information System (INIS)

    Julien, X.; Adolf, A.; Bar, E.; Beau, V.; Bordenave, E.; Chies, Th.; Courchinoux, R.; Feral, Ch.; Gendeau, P.; Graillot, H.; Grosset-Grange, C.; Henry, O.; Higonenq, V.; Journot, E.; Lacampagne, L.; Lafond, E.; Le Deroff, L.; Martinez, A.; Patissou, L.; Roques, A.; Thauvin, L.; Di-Nicola, J.M.; Thiell, G.

    2011-01-01

    The Laser Integration Line (LIL) was first designed as a prototype to validate the concepts and the laser architecture of the Laser MegaJoule (LMJ). The LIL facility is a 4-beam laser representing a quad structure of the LMJ. A set of test campaigns were conducted to safely ramp up laser performance. The main goal was to measure quad-specific features such as beam synchronization and focal spot (size, smoothing contrast ratio or irradiation nonuniformity) versus the LMJ requirements. Following the laser commissioning, the LIL has become a major instrument dedicated to the achievement of plasma physics experiments for the French Simulation Program and was also opened to the academic scientific community. One of the attributes of the LIL facility is to be very flexible to accommodate the requests of plasma physicists during campaigns. The LIL is constantly evolving to best meet the needs of target physicists. Changes made or planned are either to improve the quality of laser beams, or to increase the LIL Energy-Power operating space. To optimize preparation and design of shot campaigns, the LIL performance status has been elaborated. It gives information about the characteristics of the laser in terms of near field and far field, defines the steps to maintain performance, explains how the facility responds to the request, details settings (smoothing, shaping of the focal spot, energy, temporal pulse shaping, beam pointing) and gives the limits in energy and power. In this paper, an overview of the LIL performance is presented. (authors)

  3. Expert status and performance.

    Directory of Open Access Journals (Sweden)

    Mark A Burgman

    Full Text Available Expert judgements are essential when time and resources are stretched or we face novel dilemmas requiring fast solutions. Good advice can save lives and large sums of money. Typically, experts are defined by their qualifications, track record and experience. The social expectation hypothesis argues that more highly regarded and more experienced experts will give better advice. We asked experts to predict how they will perform, and how their peers will perform, on sets of questions. The results indicate that the way experts regard each other is consistent, but unfortunately, ranks are a poor guide to actual performance. Expert advice will be more accurate if technical decisions routinely use broadly-defined expert groups, structured question protocols and feedback.

  4. Stages of Change in Relationship Status Questionnaire: Development and Validation

    Science.gov (United States)

    Ritter, Kathrin; Handsel, Vanessa; Moore, Todd

    2016-01-01

    This study involved the development of the Stages of Change in Relationship Status (SOCRS) measure in 2 samples of college students. This scale is designed to measure how individuals progress through stages of change when terminating violent and nonviolent intimate relationships. Results indicated that the SOCRS is a reliable and valid tool to…

  5. Nutritional status according to the stages of Alzheimer's disease.

    Science.gov (United States)

    Marino, Larissa Vieira; Ramos, Liliana Figueiredo Andrade de Oliveira; Chiarello, Paula Garcia

    2015-08-01

    To assess the nutritional status of Alzheimer's disease (AD) patients with no other associated dementia, according to disease stage. Cross-sectional observational study. Neurobehavioral Diseases Outpatient Clinic, Clinical Hospital, Ribeirao Preto Medical School (University of São Paulo). The sample consisted of 36 individuals of both genders with AD diagnosis, and no other associated type of dementia, in various stages of the disease, according to the Clinical Dementia Rating (CDR 0.5-3). Nutritional status was evaluated using the Mini Nutritional Assessment (MNA) and anthropometric measurements such as weight, body mass index (BMI) and arm, waist, abdomen and hip circumferences. In addition, body composition was assessed by bioelectrical impedance analysis (BIA). The mean age of the group was 74.2 ± 10.1 years, 72.2 % of them were women. The MNA showed that most of these individuals were at risk for malnutrition (55.5 %) and many of them (43.7 %) were underweight according to BMI. Data from BIA analysis revealed that 41.7 % of these individuals had a quantity of body fat classified as malnutrition and 11.1 % had a phase angle (PA) below recommended values for age group. There was a negative and significant correlation of lean mass and PA with age, and of global MNA evaluation with CDR, as well as a positive correlation of MNA total score with fat mass and BMI. Worse classifications of nutritional status obtained by MNA scores were also observed in the more severe stages of the disease, according to the CDR. Patients with AD are mostly elderly with changes in body composition that are typical of aging, with signs of peripheral malnutrition and preservation of abdominal fat. However, greater impairment of general nutritional status was observed in the more advanced stages of AD, creating a situation of greater vulnerability for these patients.

  6. Autobiographic Performance. Intimacy as a Stage Practice

    Directory of Open Access Journals (Sweden)

    Josefina Alcázar

    2015-11-01

    Full Text Available This essay analyses performance as an expression of the age of intimacy, an age we are currently living through, where self-representation takes on a multiplicity and heterogeneity of registers and strategies. In autobiographic performance the boundary between the public and the private becomes blurred, which is expressive of the transformation of contemporary subjectivity, a search of the experience of living, and an urge to publicise intimacy. It is based on everyday life, the smaller things, not the important issues but the occurrence of the usual as it happens day by day. Performance, or action art, is an art of the self which is framed within this context of revealing one’s intimacy; and this is what makes it akin to several forms of searching for identity and self-knowledge, in which artists put their own subjectivity up on the stage.

  7. The prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status

    DEFF Research Database (Denmark)

    Dogrusöz, Mehmet; Bagger, Mette; Van Duinen, Sjoerd G.

    2017-01-01

    PURPOSE. The American Joint Committee on Cancer (AJCC) staging system has been validated for use as a prognostic parameter in uveal melanoma (UM). We studied whether adding information regarding chromosome 3 and 8q status further enhances the prognostic value of this staging system. METHODS. We...... retrospectively studied a cohort of 522 patients who had been treated for UM in two different centers between 1999 and 2015. The mean follow-up time was 47.7 months. Cumulative incidence curves were generated and regression analyses were performed for different combinations of AJCC staging and chromosome status....... Multivariable regression analyses demonstrated that AJCC staging and chromosome 3 and 8q status contain independent information about survival status. CONCLUSIONS. Combining information on AJCC staging and chromosome 3 and 8q status allows a more accurate prognostication in UM. We conclude that the prognostic...

  8. Status and performance of PF injector linac

    International Nuclear Information System (INIS)

    Sato, Isamu

    1994-01-01

    PF injector linac has been improved on a buncher section for accelerating of intense electron beam, and reinforced a focusing system of the positron generator linac for the expansion of phase space. In this presentation, I shall report present status and performance of PF injector linac, and discuss its upgrade program for B-factory project. (author)

  9. Performing Perception - Staging Aesthetics of Interaction

    DEFF Research Database (Denmark)

    Dalsgaard, Peter; Hansen, Lone Koefoed

    2008-01-01

    In interaction design for experience-oriented uses of technology, a central facet of aesthetics of interaction is rooted in the user's experience of herself “performing her perception.” By drawing on performance (theater) theory, phenomenology and sociology and with references to recent HCI-work...

  10. Mild Cognitive Impairment Status and Mobility Performance

    DEFF Research Database (Denmark)

    Pedersen, Mette; Holt, Nicole E; Grande, Laura

    2014-01-01

    BACKGROUND: The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults. METHODS......: An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (a......'s Basic Lower Extremity and Advanced Lower Extremity function scales. RESULTS: Participants had a mean age of 76.6 years, and 42% were characterized with MCI. Participants with MCI performed significantly worse than participants without MCI (No-MCI) on all performance and self-report measures (p

  11. Impact of cancer, type, site, stage and treatment on the nutritional status of patients

    International Nuclear Information System (INIS)

    Bozzeti, F.

    1982-01-01

    This study analyzed the nutritional status of cancer patients in relation to type and site of origin of the tumor, stage of disease, and previous chemical or radiation therapy. The analysis was performed on 321 patients (280 with cancer and 41 controls). The nutritional parameters included per cent of weight loss, anthropometric indices (arm circumference, triceps skinfold, arm muscle circumference), creatinine-height index, serum protein, albumin, total iron binding capacity and cholinesterase, C 3 and C 4 components of complement, total peripheral lymphocytes, and skin tests. The statistical comparison between patients with different tumors and controls, between patients treated with or without previous chemical or radiation therapy led to the following conclusions: (1) malnutrition is mainly related to the type and site of origin of the tumor and, in the early stages of disease, is more pronounced in patients with cancer of the esophagus and stomach; (2) except in patients with breast and cervix cancer, malnutrition gets more severe as the disease becomes advanced; (3) chemical or radiation therapy has a variable impact on the nutritional status, but in selected patients it causes a drop in body weight, arm circumference, arm muscle circumference, and peripheral lymphocytes; (4) body weight, cutaneous delayed hypersensitivity and serum albumin are the most commonly altered parameters

  12. On the performance simulation of inter-stage turbine reheat

    International Nuclear Information System (INIS)

    Pellegrini, Alvise; Nikolaidis, Theoklis; Pachidis, Vassilios; Köhler, Stephan

    2017-01-01

    Highlights: • An innovative gas turbine performance simulation methodology is proposed. • It allows to perform DP and OD performance calculations for complex engines layouts. • It is essential for inter-turbine reheat (ITR) engine performance calculation. • A detailed description is provided for fast and flexible implementation. • The methodology is successfully verified against a commercial closed-source software. - Abstract: Several authors have suggested the implementation of reheat in high By-Pass Ratio (BPR) aero engines, to improve engine performance. In contrast to military afterburning, civil aero engines would aim at reducing Specific Fuel Consumption (SFC) by introducing ‘Inter-stage Turbine Reheat’ (ITR). To maximise benefits, the second combustor should be placed at an early stage of the expansion process, e.g. between the first and second High-Pressure Turbine (HPT) stages. The aforementioned cycle design requires the accurate simulation of two or more turbine stages on the same shaft. The Design Point (DP) performance can be easily evaluated by defining a Turbine Work Split (TWS) ratio between the turbine stages. However, the performance simulation of Off-Design (OD) operating points requires the calculation of the TWS parameter for every OD step, by taking into account the thermodynamic behaviour of each turbine stage, represented by their respective maps. No analytical solution of the aforementioned problem is currently available in the public domain. This paper presents an analytical methodology by which ITR can be simulated at DP and OD. Results show excellent agreement with a commercial, closed-source performance code; discrepancies range from 0% to 3.48%, and are ascribed to the different gas models implemented in the codes.

  13. INVESTIGATION OF PERFORMANCE CURVES OF THREE STAGE DEEP WELL PUMPS

    OpenAIRE

    Mustafa GÖLCÜ

    2002-01-01

    In literature, pumps which are known as vertical turbine pump (VTP) have been designed to work vertically. Today, they are known as deep well pumps. These pumps are especially used in narrow and very deep wells where the surface sources are insufficient. Therefore, it is necessary to select suitable stage number to benefit from deep well pumps efficiently. In this study, a new deep well pump has been designed and the performances of three stage deep well pumps have been investigated experimen...

  14. Individual socioeconomic status and breast cancer diagnostic stages: a French case-control study.

    Science.gov (United States)

    Orsini, Mattea; Trétarre, Brigitte; Daurès, Jean-Pierre; Bessaoud, Faiza

    2016-06-01

    Health inequalities have increased over the last 30 years. Our goal was to investigate the relationship between low individual socioeconomic status and poor breast cancer prognosis. Our hypothesis was: low socioeconomic status patients have a higher risk of being diagnosed with late stage breast cancer than high socioeconomic status ones due to delayed diagnosis. We conducted a matched case-control study on 619 women with breast cancer, living in the Hérault, a French administrative area. Both Cases and Controls were recruited among invasive cases diagnosed in 2011 and 2012 and treated in Hérault care centers. Cases were defined as patients with advanced stages. Controls were composed of early stage patients. Individual socioeconomic status was assessed using a validated individual score adapted to the French population and health care system. We observed that low socioeconomic status patients have a 2-fold risk of having late stage breast cancer regardless of cancer characteristics and detection mode (screening vs. clinical signs). One reason explaining those results could be that low socioeconomic status patients have less regular follow-up which can lead to later and poorer diagnosis. Follow-up is improved for women with a better awareness of breast cancer. Health policy makers could reduce health inequalities by reducing the delay in breast cancer diagnosis for low socioeconomic status women. © The Author 2016. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  15. ACCESS: Thermal Mechanical Design, Performance, and Status

    Science.gov (United States)

    Kaiser, Mary Elizabeth; Morris, M. J.; McCandliss, S. R.; Rauscher, B. J.; Kimble, R. A.; Kruk, J. W.; Wright, E. L.; Bohlin, R.; Kurucz, R. L.; Riess, A. G.; Pelton, R.; Deustua, S. E.; Dixon, W. V.; Sahnow, D. J.; Benford, D. J.; Gardner, J. P.; Feldman, P. D.; Moos, H. W.; Lampton, M.; Perlmutter, S.; Woodgate, B. E.

    2014-01-01

    Systematic errors associated with astrophysical data used to probe fundamental astrophysical questions, such as SNeIa observations used to constrain dark energy theories, are now rivaling and exceeding the statistical errors associated with these measurements. ACCESS: Absolute Color Calibration Experiment for Standard Stars is a series of rocket-borne sub-orbital missions and ground-based experiments designed to enable improvements in the precision of the astrophysical flux scale through the transfer of absolute laboratory detector standards from the National Institute of Standards and Technology (NIST) to a network of stellar standards with a calibration accuracy of 1% and a spectral resolving power of 500 across the 0.35 - 1.7μm bandpass. Achieving this level of accuracy requires characterization and stability of the instrument and detector including a thermal background that contributes less than 1% to the flux per resolution element in the NIR. We will present the instrument and calibration status with a focus on the thermal mechanical design and associated performance data. The detector control and performance will be presented in a companion poster (Morris, et al). NASA APRA sounding rocket grant NNX08AI65G supports this work.

  16. Different stages and status of vertical transporting process of Cu in Jiaozhou Bay

    Science.gov (United States)

    Yang, Dongfang; Li, Haixia; Wang, Qi; Zhang, Xiaolong; Ding, Jun

    2017-12-01

    Understanding the stages and status of vertical transporting process of pollutant in marine bay is essential to pollution control. This paper analyzed the stages and status of Cu’s vertical transporting process in waters in Jiaozhou Bay. Results showed that the vertical transporting process in waters in Jiaozhou Bay included four stages of 1) Cu was imported to the bay by major sources, 2) Cu was transported to surface waters, 3) Cu was transported from surface waters to sediment in sea bottom, and 4) Cu was fixed and buried in sediment. Furthermore, Cu’s vertical transporting process could be divided into seven status in detail, and he characteristics of the vertical transport process of Cu were also analyzed.

  17. Design, Construction and Measured Performance of a Single-Stage ...

    African Journals Online (AJOL)

    The design philosophy, construction and measured performances of a single stage, single entry centrifugal pump demonstration unit are presented. In the construction, close-coupled induction motor drives the centrifugal pump, which draws fluid (water) from a water storage tank and delivers same through a flow control ...

  18. FOOD CONSUMPTION OF CIRRHOTIC PATIENTS, COMPARISON WITH THE NUTRITIONAL STATUS AND DISEASE STAGING

    Directory of Open Access Journals (Sweden)

    Flavia Feijó NUNES

    Full Text Available ABSTRACT Background Patients with liver disease often present protein-energy malnutrition. The assessment of food intake is very important in the investigation regarding the "health-disease" process. Objective To assess dietary intake of cirrhotic patients through food record during 3 days, correlating it with the nutritional status of the patient and the stage of the disease. Methods Cirrhotic outpatients from the Santa Casa de Misericórdia Hospital, RS, Brazil, were assessed. Nutritional assessment was performed by anthropometry; non-dominating handgrip strength; adductor pollicis muscle thickness; phase angle by bioelectrical impedance analysis; and Subjective Global Assessment. For analysis of food consumption we used the food records of 3 days using scales for weighing of all foods. Results We evaluated 25 (68% patients, in which there was a prevalence of cirrhosis by hepatitis C virus. The upper arm circumference, handgrip strength and phase angle by bioelectrical impedance analysis diagnosed 56% of malnourished. Phase angle by bioelectrical impedance analysis and upper arm circumference were associated with Child-Pugh score (P<0.05. The average consumption of calories, carbohydrates, proteins and lipids were within the recommended. However, sodium was above the recommendations, 106±57.2 mEq, and was inversely associated with Child-Pugh score (rs=-0.410; P=0.042. Conclusion Food intake did not have a significant difference between the Child-Pugh scores and nutritional status. In addition, food intake did not vary neither according to the stage of the disease, nor to the nutritional assessment, by the phase angle by bioelectrical impedance analysis.

  19. Body Presence on Stage in Performance Studies and in Ethnoscenology

    Directory of Open Access Journals (Sweden)

    Armindo Jorge de Carvalho Bião

    2011-11-01

    Full Text Available This is a brief analysis on the titles of two related cross-disciplinary contemporary perspectives, in the university context, which seek to articulate theory and practice, arts and sciences, creation and criticism, cultural diversity and specific contexts, Ethnoscenology and Performance Studies, with emphasis on the explicit statement of their focus of interest, respectively performance and body presence on stage, and a statement about preferable choices.

  20. Staged pallidotomy: MRI and clinical follow-up in status dystonicus.

    Science.gov (United States)

    Franzini, Angelo; Levi, Vincenzo; Franzini, Andrea; Dones, Ivano; Messina, Giuseppe

    2017-11-28

    We report on a patient affected by Status Distonicus who was treated with Deep Brain Stimulation electrodes implanted in the Globus Pallidus internus (Gpi) and used for serial radiofrequency lesions. The evolution of radiofrequency lesions was monitored by post-operative and late Magnetic Resonance Imaging (MRI). After the first lesion the patient did improve, though not in a significant fashion. Therefore, three further radiofrequency lesions were delivered 2, 4 and 6 days respectively after surgery with subsequent improvement of dystonic movements. MRI scans performed at 8 days, 3 months, and 6 months after surgery showed a diffuse T2-hyperintense and T1-hypointense GPi signal alteration which progressively decreased over time. We confirm that the possibility to stage pallidotomies over time using a couple of new contacts is a safe and efficacious procedure in treating SD patients where the lesions themselves are limited by the appearance of side effects, or in patients showing a poor response to a single lesion. As far as we know, this is the first description of MRI evolution and monitoring of a staged pallidotomy.

  1. [Association between stages of behavior change related to physical activity and nutritional status in university students].

    Science.gov (United States)

    Madureira, Alberto Saturno; Corseuil, Herton Xavier; Pelegrini, Andreia; Petroski, Edio Luiz

    2009-10-01

    This study aimed to verify the association between stages of behavior change related to physical activity and nutritional status among 862 university students. Body mass index cut-off values were used to classify nutritional status. Stages of behavior change were analyzed individually and classified into active (action, maintenance) and inactive (pre-contemplation, contemplation, preparation). The most prevalent stages of behavior change were contemplation (32%) and preparation (29.5%). Among the entire sample of students, 68.4% were inactive. Prevalence rates for underweight, overweight, and obesity were 9.5%, 12.4%, and 1.7%, respectively. Students classified in the pre-contemplation stage were 5.99 times (CI95%: 2.29-15.68) and 7.98 times (CI95%: 1.41-45.32) more likely to be underweight and overweight, respectively. The university plays a fundamental role in adopting plans and actions targeting the academic community, promoting lifestyle changes through physical activity programs.

  2. The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer

    DEFF Research Database (Denmark)

    Præstegaard, Camilla; Kjær, Susanne Krüger; Nielsen, Thor Schütt Svane

    2016-01-01

    PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES....... The observed socioeconomic difference in stage at diagnosis of ovarian cancer calls for further studies on how to reduce this diagnostic delay....

  3. Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease

    OpenAIRE

    Lukaszyk, Ewelina; Lukaszyk, Mateusz; Koc-Zorawska, Ewa; Bodzenta-Lukaszyk, Anna; Malyszko, Jolanta

    2017-01-01

    Background/aims Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters. Methods Eighty-eight patients with early stages of CKD and 23 healthy volunteers were enrolled in the study. Zonu...

  4. Status and Performance of University Librarians in Uganda ...

    African Journals Online (AJOL)

    It was also found that the status of university librarians is a significant predictor of their performance. Therefore, the paper urges university administrators in the country to re-examine the status accorded to their librarians because it is an important ingredient in their performance. Keywords: Library management; Performance ...

  5. Composers on Stage: Ambiguous Authorship in Contemporary Music Performance

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    2016-01-01

    In recent years, workflows within the field of contemporary classical music have changed drastically. Increasingly, composers are active in the process of creating and co-creating performances, not only the auditory dimensions but also the visual design and theatrical staging. The practice has...... but involving themselves in other ways. The article explores the ambivalent authorship at stake in these performances, arguing that they appear to be projects that reveal the processes of musical performance in ways that undermine the Romantic idea of the composer while concurrently celebrating that very same...

  6. The LHCb experiment: status and expected physics performance

    OpenAIRE

    Barsuk, S

    2005-01-01

    Physics motivation of the LHCb experiment, detector design, status of construction and installation of the detector components, and expected performance of selected b physics measurements are discussed.

  7. Evaluating Self-Concept and Ego Status in Erikson's Last Three Psychosocial Stages.

    Science.gov (United States)

    Hamachek, Don

    1990-01-01

    Suggests behavioral criteria that can be used for assessing the status of self-concept and ego development in Erikson's last three psychosocial stages. Presents three tables of different behavioral expressions, each providing examples of possible behaviors and implicit attitudes related to positive and negative ego resolutions associated with last…

  8. Assessment and Verification of SLS Block 1-B Exploration Upper Stage and Stage Disposal Performance

    Science.gov (United States)

    Patrick, Sean; Oliver, T. Emerson; Anzalone, Evan J.

    2018-01-01

    Delta-v allocation to correct for insertion errors caused by state uncertainty is one of the key performance requirements imposed on the SLS Navigation System. Additionally, SLS mission requirements include the need for the Exploration Up-per Stage (EUS) to be disposed of successfully. To assess these requirements, the SLS navigation team has developed and implemented a series of analysis methods. Here the authors detail the Delta-Delta-V approach to assessing delta-v allocation as well as the EUS disposal optimization approach.

  9. Role of preoperative PET-CT in assessing mediastinal and hilar lymph node status in early stage lung cancer

    Directory of Open Access Journals (Sweden)

    Wei-Yang Lin

    2012-05-01

    Conclusion: Integrated PET-CT is a useful tool for predicting the negativity of mediastinal LN status pre-operatively in clinically early stage (Stages I and II lung cancer but may be relatively inaccurate in predicting hilar LN status and largely confounded by false positives caused by inflammatory process.

  10. Assessment and Verification of SLS Block 1-B Exploration Upper Stage State and Stage Disposal Performance

    Science.gov (United States)

    Patrick, Sean; Oliver, Emerson

    2018-01-01

    One of the SLS Navigation System's key performance requirements is a constraint on the payload system's delta-v allocation to correct for insertion errors due to vehicle state uncertainty at payload separation. The SLS navigation team has developed a Delta-Delta-V analysis approach to assess the effect on trajectory correction maneuver (TCM) design needed to correct for navigation errors. This approach differs from traditional covariance analysis based methods and makes no assumptions with regard to the propagation of the state dynamics. This allows for consideration of non-linearity in the propagation of state uncertainties. The Delta-Delta-V analysis approach re-optimizes perturbed SLS mission trajectories by varying key mission states in accordance with an assumed state error. The state error is developed from detailed vehicle 6-DOF Monte Carlo analysis or generated using covariance analysis. These perturbed trajectories are compared to a nominal trajectory to determine necessary TCM design. To implement this analysis approach, a tool set was developed which combines the functionality of a 3-DOF trajectory optimization tool, Copernicus, and a detailed 6-DOF vehicle simulation tool, Marshall Aerospace Vehicle Representation in C (MAVERIC). In addition to delta-v allocation constraints on SLS navigation performance, SLS mission requirement dictate successful upper stage disposal. Due to engine and propellant constraints, the SLS Exploration Upper Stage (EUS) must dispose into heliocentric space by means of a lunar fly-by maneuver. As with payload delta-v allocation, upper stage disposal maneuvers must place the EUS on a trajectory that maximizes the probability of achieving a heliocentric orbit post Lunar fly-by considering all sources of vehicle state uncertainty prior to the maneuver. To ensure disposal, the SLS navigation team has developed an analysis approach to derive optimal disposal guidance targets. This approach maximizes the state error covariance prior

  11. The national ignition facility performance status

    Energy Technology Data Exchange (ETDEWEB)

    Haynam, C.; Auerbach, J.; Bowers, M.; Di-Nicola, J.M.; Dixit, S.; Erbert, G.; Heestand, G.; Henesian, M.; Jancaitis, K.; Manes, K.; Marshall, C.; Mehta, N.; Nostrand, M.; Orth, C.; Sacks, R.; Shaw, M.; Sutton, S.; Wegner, P.; Williams, W.; Widmayer, C.; White, R.; Yang, S.; Van Wonterghem, B. [Lawrence Livermore National Laboratory, Livermore, CA (United States)

    2006-06-15

    The National Ignition Facility (NIF) laser has been designed to support high energy density science, including the demonstration of fusion ignition through Inertial Confinement. NIF operated a single 'quad' of 4 beams from December 2002 through October 2004 in order to gain laser operations experience, support target experiments, and demonstrate laser performance consistent with NIF's design requirement. During this two-year period, over 400 Main Laser shots were delivered at 1{omega} to calorimeters for diagnostic calibration purposes, at 3{omega} to the Target Chamber, and at 1{omega}, 2{omega}, and 3{omega} to the precision diagnostic system (PDS). The PDS includes its own independent single beam transport system, NIF design frequency conversion hardware and optics, and laser sampling optics that deliver light to a broad range of laser diagnostics. Highlights of NIF laser performance will be discussed including the results of high energy 2{omega} and 3{omega} experiments, the use of multiple focal spot beam conditioning techniques, the reproducibility of laser performance on multiple shots, the generation on a single beam of a 3{omega} temporally shaped ignition pulse at full energy and power, and recent results on full bundle (8 beamline) performance. NIF's first quad laser performance meets or exceeds NIF's design requirements. (authors)

  12. The National Ignition Facility Performance Status

    Energy Technology Data Exchange (ETDEWEB)

    Haynam, C; Auerbach, J; Nicola, J D; Dixit, S; Heestand, G; Henesian, M; Jancaitis, K; Manes, K; Marshall, C; Mehta, N; Nostrand, M; Orth, C; Sacks, R; Shaw, M; Sutton, S; Wegner, P; Williams, W; Widmayer, C; White, R; Yang, S; Van Wonterghem, B

    2005-08-30

    The National Ignition Facility (NIF) laser has been designed to support high energy density science (HEDS), including the demonstration of fusion ignition through Inertial Confinement. NIF operated a single ''quad'' of 4 beams from December 2002 through October 2004 in order to gain laser operations experience, support target experiments, and demonstrate laser performance consistent with NIF's design requirement. During this two-year period, over 400 Main Laser shots were delivered at 1{omega} to calorimeters for diagnostic calibration purposes, at 3{omega} to the Target Chamber, and at 1{omega}, 2{omega}, and 3{omega} to the Precision Diagnostics System (PDS). The PDS includes its own independent single beam transport system, NIF design frequency conversion hardware and optics, and laser sampling optics that deliver light to a broad range of laser diagnostics. Highlights of NIF laser performance will be discussed including the results of high energy 2{omega} and 3{omega} experiments, the use of multiple focal spot beam conditioning techniques, the reproducibility of laser performance on multiple shots, the generation on a single beam of a 3{omega} temporally shaped ignition pulse at full energy and power, and recent results on full bundle (8 beamline) performance. NIF's first quad laser performance meets or exceeds NIF's design requirements.

  13. Protocol for the CONVERT trial-Concurrent ONce-daily VErsus twice-daily RadioTherapy: an international 2-arm randomised controlled trial of concurrent chemoradiotherapy comparing twice-daily and once-daily radiotherapy schedules in patients with limited stage small cell lung cancer (LS-SCLC) and good performance status.

    Science.gov (United States)

    Faivre-Finn, Corinne; Falk, Sally; Ashcroft, Linda; Bewley, Michelle; Lorigan, Paul; Wilson, Elena; Groom, Nicki; Snee, Michael; Fournel, Pierre; Cardenal, Felipe; Bezjak, Andrea; Blackhall, Fiona

    2016-01-20

    Concurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) is the only multicentre, international, randomised, phase III trial open in Europe and Canada looking at optimisation of chemoradiotherapy (RT) in limited stage small cell lung cancer (LS-SCLC). Following on from the Turrisi trial of once-daily versus twice-daily (BD) concurrent chemoradiotherapy, there is a real need for a new phase III trial using modern conformal RT techniques and investigating higher once-daily radiation dose. This trial has the potential to define a new standard chemo-RT regimen for patients with LS-SCLC and good performance status. 447 patients with histologically or cytologically proven diagnosis of SCLC were recruited from 74 centres in eight countries between 2008 and 2013. Patients were randomised to receive either concurrent twice-daily RT(45 Gy in 30 twice-daily fractions over 3 weeks) or concurrent once-daily RT(66 Gy in 33 once-daily fractions over 6.5 weeks) both starting on day 22 of cycle 1. Patients are followed up until death. The primary end point of the study is overall survival and secondary end points include local progression-free survival, metastasis-free survival, acute and late toxicity based on the Common Terminology Criteria for Adverse Events V.3.0, chemotherapy and RTdose intensity. The trial received ethical approval from NRES Committee North West-Greater Manchester Central (07/H1008/229). There is a trial steering committee, including independent members and an independent data monitoring committee. Results will be published in a peer-reviewed journal and presented at international conferences. ISRCTN91927162; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. The effect of regular hemodialysis on the nutritional status of children with end-stage renal disease

    Directory of Open Access Journals (Sweden)

    Hala M Lotfy

    2015-01-01

    Full Text Available Growth failure is one of the most common and profound clinical manifestation of chronic kidney disease (CKD in infants, children and adolescents. The aim of this study was to assess the nutritional status of Egyptian children with end-stage renal disease (ESRD on regular hemodialysis (HD. The study included 50 Egyptian children with ESRD on regular HD, following-up at the Pediatric Nephrology unit, Cairo University. History, including dietary history, was taken for all patients and clinical examination was performed on all of them. Body weight, standing height, height or length SD score, the skin fold thickness, mid-arm circumference, mid-arm muscle circumference and mid-arm muscle circumference area were also assessed. The height of the patients was the most affected anthropometric parameter, as 78% of the patients were shorter (height SDS below -3. Body weight is less affected than height, as body weight SDS of 34% of patients was less than -3 SDS. In addition, the body mass index of 16% of the patients was 97 th percentile. Although most ESRD patients received adequate protein and caloric intake, their growth was markedly affected, especially with longer period on HD. We suggest that assessment of growth parameters should be performed at a minimum period of every six months in children with CKD stages 2-3. For children with more advanced CKD (stages 4-5 and 5D, more frequent evaluation may be warranted due to the greater risk of abnormalities.

  15. The effect of regular hemodialysis on the nutritional status of children with end-stage renal disease.

    Science.gov (United States)

    Lotfy, Hala M; Sabry, Samar M; Ghobrial, Emad E; Abed, Samer A

    2015-03-01

    Growth failure is one of the most common and profound clinical manifestation of chronic kidney disease (CKD) in infants, children and adolescents. The aim of this study was to assess the nutritional status of Egyptian children with end-stage renal disease (ESRD) on regular hemodialysis (HD). The study included 50 Egyptian children with ESRD on regular HD, following-up at the Pediatric Nephrology unit, Cairo University. History, including dietary history, was taken for all patients and clinical examination was performed on all of them. Body weight, standing height, height or length SD score, the skin fold thickness, mid-arm circumference, mid-arm muscle circumference and mid-arm muscle circumference area were also assessed. The height of the patients was the most affected anthropometric parameter, as 78% of the patients were shorter (height SDS below -3). Body weight is less affected than height, as body weight SDS of 34% of patients was less than -3 SDS. In addition, the body mass index of 16% of the patients was 97 th percentile. Although most ESRD patients received adequate protein and caloric intake, their growth was markedly affected, especially with longer period on HD. We suggest that assessment of growth parameters should be performed at a minimum period of every six months in children with CKD stages 2-3. For children with more advanced CKD (stages 4-5 and 5D), more frequent evaluation may be warranted due to the greater risk of abnormalities.

  16. Staging Icons, Performing Storyworlds – From Mystery Play to Cosplay

    Directory of Open Access Journals (Sweden)

    Domsch Sebastian

    2014-12-01

    Full Text Available One of the oldest complex forms of intermediality is the static live-performance adaptation of the iconographic qualities of well-known stories. Early examples of this phenomenon are the depictions of biblical scenes in the form of grand (and largely static tableaux in medieval Mystery Plays, very popular until the emergence of the professional entertainment stage. The nineteenth century had its fascination with the tableaux vivants - not coincidentally during the time that photography was introduced - and the late twentieth century saw the beginning of the newest variety with cosplay, which has by now become a global cultural phenomenon. Cosplay, the activity of fans dressing up and posing in a visually recognizable way as characters from popular media franchises such as manga, anime, or TV series, developed from role-playing activities into its current, highly ritualized static form through its symbiosis with amateur photography. This paper wants to first analyse the underlying art form in its historical varieties from an intermedial perspective, and in connection with that, it will explore the deeper philosophical significance of this practice, looking particularly at the role of embodiment.

  17. The Relationship between Ego Identity Status and Erikson's Notions of Institutionalized Moratoria, Value Orientation Stage, and Ego Dominance.

    Science.gov (United States)

    Cote, James E.; Levine, Charles

    1988-01-01

    The results of an empirical investigation with 122 university students are discussed in terms of J. E. Marcia's identity status paradigm. E. H. Erikson's notions of institutionalized moratoria, value orientation stages, and the ego-superego struggle for dominance of the personality are related to the identity status categories to the degree that…

  18. Iron Status and Inflammation in Early Stages of Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Ewelina Łukaszyk

    2015-06-01

    Full Text Available Background/Aims: One of the most common causes of anemia of chronic disease (ACD is chronic kidney disease. The main pathomechanism responsible for ACD is subclinical inflammation. The key element involved in iron metabolism is hepcidin, however, studies on new indices of iron status are in progress.The aim of the study was to assess the iron status in patients in early stages of chronic kidney disease, iron correlation with inflammation parameters and novel biomarkers of iron metabolism. Methods: The study included 69 patients. Standard laboratory measurements were used to measure the iron status, complete blood count, fibrinogen, prothrombin index, C-reactive protein concentration (CRP, creatinine, urea, uric acid. Commercially available kits were used to measure high-sensitivity CRP, interleukin 6 (IL-6, hepcidin-25, hemojuvelin, soluble transferrin receptor (sTfR, growth differentiation factor-15 (GDF-15 and zonulin. Results: Absolute iron deficiency was present in 17% of the patients, functional iron deficiency was present in 12% of the patients. Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency. In comparison with patients without iron deficiency, patients with functional iron deficiency were older, with lower prothrombin index, higher fibrinogen, CRP, hsCRP, sTfR, GDF-15, urea and lower eGFR. Hepcidin was predicted by markers of inflammation:ferritin, fibrinogen and IL-6. Conclusion: Inflammation is correlated with iron status. Novel biomarkers of iron metabolism might be useful to distinguish iron deficiency anemia connected with inflammation and absolute iron deficiency.

  19. Nutritional Status and Cognitive Performance among Children Aged ...

    African Journals Online (AJOL)

    Without adequate nutrition, children cannot develop to their full physical and mental potentials. The nutritional status and the cognitive performance of 500 school children aged 5-12 years from urban and rural areas of Enugu State, Nigeria were evaluated. Anthropometric measurements of heights and weights were ...

  20. the relationship of birth status and early reproductive performance ...

    African Journals Online (AJOL)

    The effectiveness of selection for improvement in reproductive performance of sheep depends on measure- ment at any early age. For this reason selection of rams and ewes on their birth status, (single or twin), (Kennedy,. 1967; Turner, Hayman, Triffitt and Prunster, 1969), and ewes having multiple births during their first or ...

  1. The Reproduction Performance of Tegal Duck Based on Hematology Status

    Directory of Open Access Journals (Sweden)

    Ismoyowati Ismoyowati

    2006-05-01

    Full Text Available The experiment was conducted to study the physiological indicator of Tegal duck based on the hematological parameters and its relation to reproduction performances.  The research materials were 20 heads of male and 100 heads of female Tegal ducks. Parameters measured were erytrocyte, leucocyte, differential leucocyte, hemoglobin, hematocrit, protein total, albumin and globulin, and reproduction performances (semen volume and egg production.  Method of the research was experimental with Completely Randomized Design,  and data were analysed using analysis of variance and correlation.  The result of the experiment showed that hematological parameters of Tegal duck that had high production were high significantly (P<0,05 different than the others, except on albumin value.  It was concluded that reprodution performances of Tegal duck was highly affected by its hematologys status. (Animal Production 8(2: 88-93 (2006   Key Words: Reproduction performances, Tegal duck, hematology status

  2. Redox Status of β2GPI in Different Stages of Diabetic Angiopathy

    Directory of Open Access Journals (Sweden)

    Jun Ma

    2016-01-01

    Full Text Available We explored the redox status of beta 2 glycoprotein I (β2GPI in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM had a significantly lower proportion of reduced β2GPI as compared to healthy controls (p0.05. The mild-A-stenosis group and mild-diabetic retinopathy (DR groups had higher proportion of reduced β2GPI than their severely affected counterparts. The mild-slow nerve conduction velocity (NCVS group had higher proportion of reduced β2GPI than normal nerve conduction velocity (NCVN group and severe-NCVS groups. The proportion of reduced β2GPI was in positive correlation with 24 h urine microalbumin and total urine protein, and the proportion of reduced β2GPI was in negative correlation with serum and skin advanced glycation end products (AGEs. Taken together, our data implicate that the proportion of reduced β2GPI increased in the early stage of angiopathy and decreased with the aggravation of angiopathy.

  3. Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease.

    Science.gov (United States)

    Lukaszyk, Ewelina; Lukaszyk, Mateusz; Koc-Zorawska, Ewa; Bodzenta-Lukaszyk, Anna; Malyszko, Jolanta

    2018-01-01

    Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters. Eighty-eight patients with early stages of CKD and 23 healthy volunteers were enrolled in the study. Zonulin, hepcidin-25, soluble transferrin receptor, interleukin-6 and high-sensitivity C-reactive protein were measured using commercially available assays. Zonulin was significantly lower among patients with CKD in comparison with healthy volunteers. There were no statistically significant differences in zonulin concentration between patients with and without inflammation. Zonulin was significantly correlated with hepcidin only in patients with inflammation. Zonulin was neither related to iron nor related to ferritin. Zonulin cannot be considered as an inflammatory marker in CKD. It does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.

  4. [An assessment of nutritional status in children on maintenance hemodialysis due to stage 5 chronic kidney disease].

    Science.gov (United States)

    Jiang, Ye-Ping; Shen, Ying; Liu, Xiao-Rong

    2018-03-01

    To investigate the nutritional status of children on maintenance hemodialysis due to stage 5 chronic kidney disease (CKD) and the clinical significance of nutritional assessment indices. A total of 21 children on maintenance hemodialysis due to stage 5 CKD were grouped according to body mass index. The nutritional status was assessed based on anthropometric parameters, biochemical parameters, inflammatory factors, residual renal function, indices of dialysis adequacy, and resting energy expenditure. Related indices were compared between the children with malnutrition and those with normal nutritional status. Of the 21 children, 10 had malnutrition and 11 had normal nutritional status. There were significant differences between the two groups in anthropometric parameters, levels of leptin, insulin-like growth factor-1, interleukin-1, interleukin-6, and tumor necrosis factor-α, and mean 24-hour residual urine volume (Pnutritional status of children with stage 5 CKD on maintenance hemodialysis. Further studies are needed to investigate the value of the measurement of resting energy expenditure in the evaluation and monitoring of nutritional status in children with stage 5 CKD on maintenance hemodialysis.

  5. STATUS OF THE ATLAS LIQUID ARGON CALORIMETER AND ITS PERFORMANCE

    CERN Document Server

    Berillari, T; The ATLAS collaboration

    2011-01-01

    The liquid argon (LAr) calorimeters are used in ATLAS for all electromagnetic and for hadron calorimetry. The LAr calorimeter system consists of an electromagnetic barrel calorimeter and two endcaps with electromagnetic, hadronic and forward calorimeters. The latest status of the detector as well as problems and solutions addressed during the last years will be presented. Aspects of operation of a large detector over a long time period will be summarized and selected topics showing the performance of the detector will be shown.

  6. The impact of health insurance status on stage at diagnosis of oropharyngeal cancer.

    Science.gov (United States)

    Chen, Amy Y; Schrag, Nicole M; Halpern, Michael T; Ward, Elizabeth M

    2007-07-15

    Although patients who have early-stage oropharyngeal cancer can be treated with little impairment of function, the treatment of advanced disease can result in decreased quality of life and mortality. Patients without insurance and with other barriers to access to care may delay seeking medical attention for early symptoms, resulting in more advanced disease at presentation. In this study, the authors examined whether patients who had no insurance or who were covered by Medicaid insurance were more likely to present with advanced oropharyngeal cancer. In this retrospective cohort study from the National Cancer Database from 1996 to 2003, patients with known insurance status who were diagnosed with invasive oropharyngeal cancer at Commission on Cancer facilities (n = 40,487) were included. Adjusted and unadjusted logistic regression models were used to analyze the likelihood of presenting with more advanced stage disease. After controlling for other sociodemographic characteristics, patients with advanced oropharyngeal cancer at diagnosis were more likely to be uninsured (odds ratio [OR], 1.37; 95% confidence interval [95% CI], 1.21-1.25) or covered by Medicaid (OR, 1.31; 95% CI, 1.19-1.46) compared with patients who had private insurance. Similarly, patients were most likely to present with the largest tumors (T4 disease) if they were uninsured (OR, 2.82; 95% CI, 2.46-3.23) or covered by Medicaid (OR, 2.95; 95% CI, 2.63-3.31). They also were more likely to present with the greatest degree of lymph node involvement (N3) if they were uninsured (OR, 2.06; 95% CI, 1.76-2.40) or covered by Medicaid (OR, 1.66; 95% CI, 1.45-1.90). Individuals who lacked insurance or had Medicaid coverage were at the greatest risk for presenting with advanced oropharyngeal cancer. In the current study, the results for the Medicaid group may have been influenced by the postdiagnostic enrollment of uninsured patients. Insurance coverage appeared to be a highly modifiable predictor of cancer

  7. Fatigue, sleep, pain, mood, and performance status in patients with multiple myeloma.

    Science.gov (United States)

    Coleman, Elizabeth Ann; Goodwin, Julia A; Coon, Sharon K; Richards, Kathy; Enderlin, Carol; Kennedy, Robert; Stewart, Carol B; McNatt, Paula; Lockhart, Kim; Anaissie, Elias J; Barlogie, Bart

    2011-01-01

    Cancer-related fatigue and insomnia are common distressing symptoms and may affect mood and performance status. The objective of this study was to describe fatigue, sleep, pain, mood, and performance status and the relationships among these variables in 187 patients with newly diagnosed multiple myeloma (MM) and conduct an analysis using the correlates of fatigue. Data were from baseline measures from the study, using the Profile of Mood States and the Functional Assessment of Cancer Therapy-Fatigue to assess fatigue, the actigraph to measure sleep, the Wong/Baker Faces Pain Rating Scale to assess pain, the Profile of Mood States to assess mood, and the 6-minute walk test along with a back/leg/chest dynamometer to test muscle strength to assess performance status. Data analysis consisted of descriptive statistics, Pearson and Spearman ρ correlations, and multiple regression analysis using fatigue as the dependent variable. All P values were 2-sided, and Pmood disturbances, and diminished functional performance. The regression model, which included all of these variables along with age, sex, and stage of disease, was statistically significant with a large measure of effect. Mood was a significant individual contributor to the model. Among patients with MM, fatigue, pain, sleep, mood, and functional performance are interrelated. Interventions are needed to decrease fatigue and pain and to improve sleep, mood, and functional performance. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins

  8. Features of intra- and extra-cranial blood flow in patients with essential hypertension stage II according to smoking status

    Directory of Open Access Journals (Sweden)

    V. V. Syvolap

    2014-04-01

    Full Text Available Today diseases of the cardiovascular system are called the problem number 1in the world, including Ukraine. Every year more than 500 thousand Ukrainians dye from CVDs, i.e. 1370 people on average dye every day. Smoking is one of the most serious threats to health, especially with regard to cardiovascular disease. Every year, smoking kills more than 1.2 million people in Europe (of which 450 thousand - due to cardiovascular diseases and about 650 thousand people of the EU countries (including from cardiovascular problems - 185 thousand. Analysis of the literature suggests paucity and contradictory information about changes in the functional status of the various systems of the body while smoking. The aim of the work was to study the peculiarities of cerebral hemodynamics in patients with hypertension stage II depending on smoking status. Material and methods. We examined 100 patients with essential hypertension stage II low additional cardiovascular risk, 53 men and 47 women. Depending on the smoking status (at least 10 years, all patients were divided into 2 groups: a group of smokers included 30 patients, in the group of non-smokers there were 70 patients. To assess cerebral hemodynamic Doppler ultrasound and duplex scanning methods were used. Statistical processing of the material was performed using the software package Statistica 6.0 («Statsoft», USA, № license AXXR712D833214FAN5. Results and discussion. Analysis of the data shows the predominance of authentic vascular resistance index in the right CCA by 3.3% (p = 0.033, in the right MCA by 8.5% (p = 0.05, in the left MCA by 7.1% (p = 0.042 in hypertensive patients with smoking status, compared with non-smoking hypertensive patients. In smokers with hypertension statistically significant increasing of the indicator "reserve vasoconstriction" by 4.63 times (p = 0.029 in the left ICA and by 3.01 times (p = 0.031 in the right ICA was also found compared with data rates in nonsmokers

  9. Emotions in Concert : Performers' Experienced Emotions on Stage

    OpenAIRE

    Van Zijl, Anemone G. W.; Sloboda, John A.

    2013-01-01

    Music is often said to be expressive of emotions. Surprisingly, not much is known about the role of performers’ emotions while performing. Do musicians feel the musical emotions when expressing them? Or has expressive playing nothing to do with the emotional experiences of the performer? To investigate performers’ perspectives on the role of emotions in performance, we conducted qualitative in-depth interviews with nineteen musicians teaching or studying at a European conservatoire. In the in...

  10. High Performance Hybrid Upper Stage for NanoLaunch Vehicles, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Parabilis Space Technologies, Inc. (Parabilis), in collaboration with Utah State University (USU), proposes a low cost, high performance launch vehicle upper stage...

  11. Effect of lactation stage and energy status on milk fat composition of Holstein-Friesian cows.

    Science.gov (United States)

    Stoop, W M; Bovenhuis, H; Heck, J M L; van Arendonk, J A M

    2009-04-01

    The effects of lactation stage, negative energy balance (NEB), and milk fat depression (MFD) were estimated on detailed milk fat composition in primiparous Holstein-Friesian cows. One morning milk sample was collected from each of 1,933 cows from 398 commercial Dutch herds in winter 2005. Milk fat composition was measured using gas chromatography, and fat and protein percentage were measured using infrared spectrometry. Each fatty acid changed 0.5 to 1 phenotypic standard deviation over lactation, except odd-chain C5:0 to C15:0, branched-chain fatty acids, and trans-10, cis-12 conjugated linoleic acid (CLA). The greatest change was an increase from 31.2 to 33.3% (wt/wt) for C16:0 from d 80 to 150 of lactation. Energy status was estimated for each cow as the deviation from each average lactation fat-to-protein ratio (FPdev). A high FPdev (>0.12) indicated NEB. Negative energy balance was associated with an increase in C16:0 (0.696 +/- 0.178) and C18:0 (0.467 +/- 0.093), which suggested mobilization of body fat reserves. Furthermore, NEB was associated with a decrease in odd-chain C5:0 to C15:0 (-0.084 +/- 0.020), which might reflect a reduced allocation of C3 components to milk fat synthesis. A low FPdev indicated MFD (<-0.12) and was associated with a decrease in C16:0 (-0.681 +/- 0.255) and C18:0 (-0.128 +/- 0.135) and an increase in total unsaturated fatty acids (0.523 +/- 0.227). The study showed that both lactation stage and energy balance significantly contribute to variation in milk fat composition and alter the activity of different fatty acid pathways.

  12. Process performance indicators in project pre-design stage

    NARCIS (Netherlands)

    Haponava, T.; Al-Jibouri, Saad H.S.; Reymen, Isabelle; Scheublin, F.; Pronk, A.; Prins, M.; Emmitt, S.; den Otter, A

    2006-01-01

    Traditionally performance in construction is measured based on the "iron-triangle”- time, cost and quality. In recent years indicators have been developed to include the measurements of other aspects of project performance. The main shortcoming of these however is that most of them are lagging

  13. High Performance Gasification with the Two-Stage Gasifier

    DEFF Research Database (Denmark)

    Gøbel, Benny; Hindsgaul, Claus; Henriksen, Ulrik Birk

    2002-01-01

    , air preheating and pyrolysis, hereby very high energy efficiencies can be achieved. Encouraging results are obtained at a 100 kWth laboratory facility. The tar content in the raw gas is measured to be below 25 mg/Nm3 and around 5 mg/Nm3 after gas cleaning with traditional baghouse filter. Furthermore...... a cold gas efficiency exceeding 90% is obtained. In the original design of the two-stage gasification process, the pyrolysis unit consists of a screw conveyor with external heating, and the char unit is a fixed bed gasifier. This design is well proven during more than 1000 hours of testing with various...... fuels, and is a suitable design for medium size gasifiers....

  14. Highly loaded multi-stage fan drive turbine: Performance of final three configurations

    Science.gov (United States)

    Cherry, D. G.; Thomas, M. W.

    1974-01-01

    Results for a three-stage highly loaded fan drive turbine follow-on test program are presented. The effects of combinations of tandem and leaned bladerows on three-stage turbine performance were tested. The three-stage turbine with a tandem stator in stage two exhibited a total-to-total efficiency of approximately 0.887 as compared to 0.886 for the plain blade turbine base case.

  15. STATUS BERKELANJUTAN KOTA TANGERANG SELATAN-BANTEN DENGAN MENGGUNAKAN KEY PERFORMANCE INDICATORS (Sustainable Status of South Tangerang City-Banten Using Key Performance Indicators

    Directory of Open Access Journals (Sweden)

    Heri Apriyanto

    2015-07-01

    Full Text Available ABSTRAK Pembangunan kota yang tidak terkendali akan mengakibatkan tekanan terhadap lingkungan dan beban masyarakat meningkat, sebaliknya degradasi lingkungan akan mengakibatkan pembatasan pengembangan ekonomi dan penurunan kualitas hidup. Guna mencegah terjadinya dampak-dampak negatif, maka diperlukan prinsip-prinsip pembangunan kota yang berkelanjutan. Evaluasi terhadap pelaksanan pembangunan kota yang berkelanjutan perlu dilakukan untuk mengetahui apakah pembangunan suatu kota sudah atau belum/tidak berkelanjutan. Penelitian ini bertujuan untuk menyusun Key Performance Indicators (KPI guna menilai status pembangunan kota berkelanjutan. Perumusan KPI ini dilakukan dengan pendekatan Analytic Hierarchy Process (AHP. KPI yang dihasilkan terdiri dari 21 indikator dan 9 elemen dari 3 pilar pembangunan berkelanjutan (ekonomi, sosial, dan lingkungan. Implementasi KPI dilakukan untuk pengukuran status keberlanjutan Kota Tangerang Selatan. Hasil pengukuran menunjukkan bahwa kota ini termasuk dalam tahap awal pembangunan berkelanjutan. Secara umum perkembangan ekonomi dan sosial relatif cukup baik, namun tidak demikian dengan kondisi lingkungannya. ABSTRACT Uncontrolled urban development will result in pressure on the environment and the burden of the people. On the contrary, environmental degradation will lead to restricted economic development and decreased quality of life. In order to prevent negative impacts, it is necessary to implement the principles of sustainable city development. Evaluation of the implementation of sustainable city development is needed to determine whether the development of a city is sustainable or not. This study aimed to develop Key Performance Indicators (KPI to assess the status of sustainable city development. The formulation of KPI is done with Analytic Hierarchy Process (AHP. KPI generated consists of 21 indicators and 9 elements of the 3 pillars of sustainable development (economic, social, and environmental

  16. Geometric and structural-functional transformation of the heart in patients with hypertension stage II with smoking status

    Directory of Open Access Journals (Sweden)

    V. V. Syvolap

    2014-02-01

    Full Text Available Peculiarities of structure-geometric and functional state of the myocardium in patients with hypertension stage II depending on smoking status are still need to be studied. Smoking in this group of patients is associated with a greater degree of the left atrium dilatation, left ventricular hypertrophy, diastolic tension, as well as violations of the process of diastolic pressure.

  17. Building performance simulation in the early design stage: An introduction to integrated dynamic models

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    2015-01-01

    Designing with building performance simulation feedback in the early design stage has existed since the early days of computational modeling. However, as a consequence of a fragmented building industry building performance simulations (BPSs) in the early design stage are closely related to who is...

  18. Vitamin and mineral status: effects on physical performance.

    Science.gov (United States)

    Lukaski, Henry C

    2004-01-01

    Public health recommendations encourage the selection of a balanced diet and increasing physical activity to foster health and well-being. Whereas the adverse effects of restricted intakes of protein, fat, and carbohydrate on physical performance are well known, there is limited information about the impact of low intakes of vitamins and minerals on the exercise capacity and performance of humans. Physically active people generally consume amounts of vitamins and minerals consistent with the recommendations for the general public. However, when intakes are less than recommendations, some noticeable functional impairments occur. Acute or short-term marginal deficiencies, identified by blood biochemical measures of vitamin B status, had no impacts on performance measures. Severe deprivation of folate and vitamin B12 result in anemia and reduce endurance work performance. Evidence of vitamin A and E deficiencies in athletic individuals is lacking apparently because body storage is appreciable. In contrast to vitamins, marginal mineral deficiencies impair performance. Iron deficiency, with or without anemia, impairs muscle function and limits work capacity. Magnesium deprivation increases oxygen requirements to complete submaximal exercise and reduces endurance performance. Use of vitamin and mineral supplements does not improve measures of performance in people consuming adequate diets. Young girls and individuals participating in activities with weight classifications or aesthetic components are prone to nutrient deficiencies because they restrict food intake and specific micronutrient-rich foods. This information will be useful to professionals who counsel physically active people and scientific groups who make dietary recommendations to improve health and optimize genetic potential.

  19. Status, performance and scientific highlights from the MAGIC telescope system

    Energy Technology Data Exchange (ETDEWEB)

    Doert, Marlene [Technische Universitaet Dortmund (Germany); Ruhr-Universitaet Bochum (Germany); Collaboration: MAGIC-Collaboration

    2015-07-01

    The MAGIC telescopes are a system of two 17 m Imaging Air Cherenkov Telescopes, which are located at 2200 m above sea level at the Roque de Los Muchachos Observatory on the Canary Island of La Palma. In this presentation, we report on recent scientific highlights gained from MAGIC observations in the galactic and the extragalactic regime. We also present the current status and performance of the MAGIC system after major hardware upgrades in the years 2011 to 2014 and give an overview of future plans.

  20. Comorbidity and performance status in acute myeloid leukemia patients

    DEFF Research Database (Denmark)

    Østgård, Lene Sofie Granfeldt; Nørgaard, J M; Sengeløv, H

    2015-01-01

    As the world population ages, the comorbidity burden in acute myeloid leukemia (AML) patients increases. Evidence on how to integrate comorbidity measures into clinical decision-making is sparse. We determined the prognostic impact of comorbidity and World Health Organization Performance Status (...... with an increased short- and long-term mortality (adjusted 90 day MR, PS⩾2=3.43 (95%CI=2.30-5.13); adjusted 91 day-3 year MR=1.35 (95%CI=1.06-1.74)). We propose that more patients with comorbidity may benefit from intensive chemotherapy....

  1. The ATLAS liquid argon calorimeter--status and expected performance

    International Nuclear Information System (INIS)

    Schacht, Peter

    2004-01-01

    For the ATLAS detector at the LHC, the liquid argon technique is exploited for the electromagnetic calorimetry in the central part and for the electromagnetic and hadronic calorimetry in the forward and backward regions. The construction of the calorimeter is well advanced with full cold tests of the barrel calorimeter and first endcap calorimeter only months away. The status of the project is discussed as well as the related results from beam test studies of the various calorimeter subdetectors. The results show that the expected performance meets the ATLAS requirements as specified in the ATLAS Technical Design Report

  2. Performance of mitochondrial DNA mutations detecting early stage cancer

    International Nuclear Information System (INIS)

    Jakupciak, John P; Srivastava, Sudhir; Sidransky, David; O'Connell, Catherine D; Maragh, Samantha; Markowitz, Maura E; Greenberg, Alissa K; Hoque, Mohammad O; Maitra, Anirban; Barker, Peter E; Wagner, Paul D; Rom, William N

    2008-01-01

    Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites. We determined the mtDNA mutation load in the entire mitochondrial genome of 26 individuals with different early stage cancers (lung, bladder, kidney) and 12 heavy smokers without cancer. MtDNA was sequenced from three matched specimens (blood, tumor and body fluid) from each cancer patient and two matched specimens (blood and sputum) from smokers without cancer. The inherited wildtype sequence in the blood was compared to the sequences present in the tumor and body fluid, detected using the Affymetrix Genechip ® Human Mitochondrial Resequencing Array 1.0 and supplemented by capillary sequencing for noncoding region. Using this high-throughput method, 75% of the tumors were found to contain mtDNA mutations, higher than in our previous studies, and 36% of the body fluids from these cancer patients contained mtDNA mutations. Most of the mutations detected were heteroplasmic. A statistically significantly higher heteroplasmy rate occurred in tumor specimens when compared to both body fluid of cancer patients and sputum of controls, and in patient blood compared to blood of controls. Only 2 of the 12 sputum specimens from heavy smokers without cancer (17%) contained mtDNA mutations. Although patient mutations were spread throughout the mtDNA genome in the lung, bladder and kidney series, a statistically significant elevation of tRNA and ND complex mutations was detected in tumors. Our findings indicate comprehensive mtDNA resequencing can be a high-throughput tool for detecting mutations in clinical samples with potential applications for cancer detection, but it is

  3. Performance of mitochondrial DNA mutations detecting early stage cancer

    Directory of Open Access Journals (Sweden)

    Wagner Paul D

    2008-10-01

    Full Text Available Abstract Background Mutations in the mitochondrial genome (mtgenome have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy. The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites. Methods We determined the mtDNA mutation load in the entire mitochondrial genome of 26 individuals with different early stage cancers (lung, bladder, kidney and 12 heavy smokers without cancer. MtDNA was sequenced from three matched specimens (blood, tumor and body fluid from each cancer patient and two matched specimens (blood and sputum from smokers without cancer. The inherited wildtype sequence in the blood was compared to the sequences present in the tumor and body fluid, detected using the Affymetrix Genechip® Human Mitochondrial Resequencing Array 1.0 and supplemented by capillary sequencing for noncoding region. Results Using this high-throughput method, 75% of the tumors were found to contain mtDNA mutations, higher than in our previous studies, and 36% of the body fluids from these cancer patients contained mtDNA mutations. Most of the mutations detected were heteroplasmic. A statistically significantly higher heteroplasmy rate occurred in tumor specimens when compared to both body fluid of cancer patients and sputum of controls, and in patient blood compared to blood of controls. Only 2 of the 12 sputum specimens from heavy smokers without cancer (17% contained mtDNA mutations. Although patient mutations were spread throughout the mtDNA genome in the lung, bladder and kidney series, a statistically significant elevation of tRNA and ND complex mutations was detected in tumors. Conclusion Our findings indicate comprehensive mtDNA resequencing can be a high-throughput tool for detecting mutations in clinical samples with

  4. Technical area status report for second-stage destruction and offgas treatment

    International Nuclear Information System (INIS)

    French, N.B.; Dalton, J.D.; Vavruska, J.

    1994-08-01

    This report was sponsored by the Mixed Waste Integrated Program (MWIP), which was established by the Department of Energy (DOE), Office of Environmental Restoration and Waste Management (EM), Office of Technology Development (OTD). DOE/EM carries the charter to direct and coordinate waste management and site remediation throughout the DOE complex. Within EM, the OTD established the MWIP to identify and develop new technologies for treatment of DOE low-level mixed waste. This report represents the second TASR for the Second-Stage Destruction and Offgas Treatment technical area. This TASR updates technology information, a design methodology for air pollution control systems for mixed waste treatment, and technology development needs for DOE/EM. The TASRs form the basis of a technology development program that addresses the highest priority DOE environmental needs and is coordinated with other technology development efforts both inside and outside DOE. The main functions of the second-stage destruction and offgas treatment system are to treat the gaseous effluent from the primary treatment process to acceptable levels for release to the atmosphere. Specific functions include (1) destruction of volatile organics; (2) capture of particulate matter; (3) capture of volatile metals; (4) capture and control of volatile, condensed-phase, and solid-phase radionuclides; (5) control of acid gases; (6) NO x abatement; and (7) gas cooling and reheating as required to perform these functions

  5. Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification

    Science.gov (United States)

    McLean, Ashleigh C.; Valenzuela, Nicolas; Fai, Stephen; Bennett, Steffany A.L.

    2012-01-01

    A rapid means of assessing reproductive status in rodents is useful not only in the study of reproductive dysfunction but is also required for the production of new mouse models of disease and investigations into the hormonal regulation of tissue degeneration (or regeneration) following pathological challenge. The murine reproductive (or estrous) cycle is divided into 4 stages: proestrus, estrus, metestrus, and diestrus. Defined fluctuations in circulating levels of the ovarian steroids 17-β-estradiol and progesterone, the gonadotropins luteinizing and follicle stimulating hormones, and the luteotropic hormone prolactin signal transition through these reproductive stages. Changes in cell typology within the murine vaginal canal reflect these underlying endocrine events. Daily assessment of the relative ratio of nucleated epithelial cells, cornified squamous epithelial cells, and leukocytes present in vaginal smears can be used to identify murine estrous stages. The degree of invasiveness, however, employed in collecting these samples can alter reproductive status and elicit an inflammatory response that can confound cytological assessment of smears. Here, we describe a simple, non-invasive protocol that can be used to determine the stage of the estrous cycle of a female mouse without altering her reproductive cycle. We detail how to differentiate between the four stages of the estrous cycle by collection and analysis of predominant cell typology in vaginal smears and we show how these changes can be interpreted with respect to endocrine status. PMID:23007862

  6. Staging a performance: learners' perceptions about direct observation during residency.

    Science.gov (United States)

    LaDonna, Kori A; Hatala, Rose; Lingard, Lorelei; Voyer, Stephane; Watling, Christopher

    2017-05-01

    Evidence strongly supports that direct observation is a valid and reliable assessment tool; support for its impact on learning is less compelling, and we know that some learners are ambivalent about being observed. However, learners' perceptions about the impact of direct observation on their learning and professional development remain underexplored. To promote learning, we need to understand what makes direct observation valuable for learners. Informed by constructivist grounded theory, we interviewed 22 learners about their observation experiences. Data collection and analysis occurred iteratively; themes were identified using constant comparative analysis. Direct observation was widely endorsed as an important educational strategy, albeit one that created significant anxiety. Opaque expectations exacerbated participants' discomfort, and participants described that being observed felt like being assessed. Consequently, participants exchanged their 'usual' practice for a 'textbook' approach; alterations to performance generated uncertainty about their role, and raised questions about whether observers saw an authentic portrayal of their knowledge and skill. An 'observer effect' may partly explain learners' ambivalence about direct observation; being observed seemed to magnify learners' role ambiguity, intensify their tensions around professional development and raise questions about the credibility of feedback. In turn, an observer effect may impact learners' receptivity to feedback and may explain, in part, learners' perceptions that useful feedback is scant. For direct observation to be valuable, educators must be explicit about expectations, and they must be aware that how learners perform in the presence of an observer may not reflect what they do as independent practitioners. To nurture learners' professional development, educators must create a culture of observation-based coaching that is divorced from assessment and is tailored to developing learners

  7. Evaluating Changes In Fertility Status Of An Alfisol Under Different Growth Stages Of Cassava Manihot Esculenta Crantz

    Directory of Open Access Journals (Sweden)

    B. Osundare

    2015-02-01

    Full Text Available Abstract Evaluating changes in soil nutrient status under different growth stages of cassava makes possible determination of the most critical stage in its vegetative growth phase when its demand for nutrients is highest. Determining the most critical stage in cassava vegetative growth phase when its nutrient demand is highest will enhance properly timed fertilizer application in such a way the application will coincide with the most critical stage in cassava vegetative phase when its demand for nutrients is highest. In view of this a two year field experiment was designed to assess changes in nutrient status of an Alfisol under different growth stages of cassava during 2010 and 2011 cropping seasons at the Teaching and Research Farm of the Ekiti State University Ado Ekiti Ekiti State Nigeria. The experiment was laid out in a randomized complete block design with three replicates. The different growth stages of cassava when changes in nutrient status of Alfisol were evaluated included 3 6 9 and 12 months after planting MAP. The results indicated existence of significant P 0.05 differences among the different growth stages of cassava as regards their effects on chemical properties of Alfisol. During 2010 cropping season the significant decreases in soil organic carbon SOC under growth stages of cassava were from 0.96 g kg-1 for ISNSPTC to 0.88 0.80 0.72 and0.64 g kg-1 for ages 3 6 9 and 12 MAP respectively. Similarly during 2011 cropping season the significant decreases in soil organic carbon SOC under growth stages of cassava were from 0.96 g kg-1 for ISNSPTC to 0.80 0.73 0.66 and0.58 g kg-1 for ages 3 6 9 and 12 MAP respectively. During 2010 cropping season the significant decreases in total N under growth stages of cassava were from 0.68 g kg-1 for ISNSPTC to 0.57 0.50 0.43 and0.35 g kg-1 for ages 3 6 9 and 12 MAP respectively. During 2011 cropping season the significant decreases in total N under growth stages of cassava were from 0.68 g kg-1

  8. Performance of gadofosveset-enhanced MRI for staging rectal cancer nodes: can the initial promising results be reproduced?

    Energy Technology Data Exchange (ETDEWEB)

    Heijnen, Luc A.; Martens, Milou H. [Maastricht University Medical Center, Department of Radiology, P.O. Box 5800, Maastricht (Netherlands); Maastricht University Medical Center, Department of Surgery, Maastricht (Netherlands); GROW School for Oncology and Developmental Biology, Maastricht (Netherlands); Lambregts, Doenja M.J.; Maas, Monique; Bakers, Frans C.H. [Maastricht University Medical Center, Department of Radiology, P.O. Box 5800, Maastricht (Netherlands); Cappendijk, Vincent C. [Jeroen Bosch Ziekenhuis, Department of Radiology, ' s Hertogenbosch (Netherlands); Oliveira, Pedro [Instituto Portugues de Oncologia do Porto Francisco Gentil, Department of Radiology, Porto (Portugal); Lammering, Guido [Maastro Clinic, Radiation Oncology, Maastricht (Netherlands); GROW School for Oncology and Developmental Biology, Maastricht (Netherlands); Riedl, Robert G. [Maastricht University Medical Center, Department of Pathology, Maastricht (Netherlands); Beets, Geerard L. [Maastricht University Medical Center, Department of Surgery, Maastricht (Netherlands); GROW School for Oncology and Developmental Biology, Maastricht (Netherlands); Beets-Tan, Regina G.H. [Maastricht University Medical Center, Department of Radiology, P.O. Box 5800, Maastricht (Netherlands); GROW School for Oncology and Developmental Biology, Maastricht (Netherlands)

    2014-02-15

    A previous study showed promising results for gadofosveset-trisodium as a lymph node magnetic resonance imaging (MRI) contrast agent in rectal cancer. The aim of this study was to prospectively confirm the diagnostic performance of gadofosveset MRI for nodal (re)staging in rectal cancer in a second patient cohort. Seventy-one rectal cancer patients were prospectively included, of whom 13 (group I) underwent a primary staging gadofosveset MRI (1.5-T) followed by surgery (± preoperative 5 x 5 Gy) and 58 (group II) underwent both primary staging and restaging gadofosveset MRI after a long course of chemoradiotherapy followed by surgery. Nodal status was scored as (y)cN0 or (y)cN+ by two independent readers (R1, R2) with different experience levels. Results were correlated with histology on a node-by-node basis. Sensitivity, specificity and area under the receiver operating characteristics curve (AUC) were 94 %, 79 % and 0.89 for the more experienced R1 and 50 %, 83 % and 0.74 for the non-experienced R2. R2's performance improved considerably after a learning curve, to an AUC of 0.83. Misinterpretations mainly occurred in nodes located in the superior mesorectum, nodes located in between vessels and nodes containing micrometastases. This prospective study confirms the good diagnostic performance of gadofosveset MRI for nodal (re)staging in rectal cancer. (orig.)

  9. Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: national cohort study in England.

    Science.gov (United States)

    Møller, Henrik; Henson, Katherine; Lüchtenborg, Margreet; Broggio, John; Charman, Jackie; Coupland, Victoria H; Davies, Elizabeth; Jack, Ruth H; Sullivan, Richard; Vedsted, Peter; Horgan, Kieran; Pearce, Neil; Purushotham, Arnie

    2016-11-22

    In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items. We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). The follow-up ended on 31 December 2014. The completeness of registration for prognostic variables was generally high (around 80% or higher), but it was low for progesterone receptor status (41%). Women with negative receptor status for each of the oestrogen, progesterone and HER2 receptors (triple-negative cancers) had an adjusted HR for death of 2.00 (95%CI 1.84-2.17). Black women had an age-adjusted HR of 1.77 (1.48-2.13) compared with White women. The excess mortality of Black women with breast cancer has contributions from socio-economic factors, stage distribution and tumour biology. The study illustrates the richness of detail in the national cancer registration data. This allows for analysis of cancer outcomes at a high level of resolution, and may form the basis for risk stratification.

  10. The relation between lymph node status and survival in Stage I-III colon cancer

    DEFF Research Database (Denmark)

    Lykke, J.; Roikjær, Ole; Jess, P.

    2013-01-01

    Aim: This study involved a large nationwide Danish cohort to evaluate the hypothesis that a high lymph node harvest has a positive effect on survival in curative resected Stage I-III colon cancer and a low lymph node ratio has a positive effect on survival in Stage III colon cancer. Method......: Analysis of overall survival was conducted using a nationwide Danish cohort of patients treated with curative resection of Stage I-III colon cancer. All 8901 patients in Denmark diagnosed with adenocarcinoma of the colon and treated with curative resection in the period 2003-2008 were identified from...... independent prognostic factors in multivariate analysis. Conclusion: High lymph node count was associated with improved overall survival in colon cancer. Lymph node ratio was superior to N-stage in differentiating overall survival in Stage III colon cancer. Stage migration was observed....

  11. Advanced fuel technology and performance: Current status and trends

    International Nuclear Information System (INIS)

    1990-11-01

    During the last years the Nuclear Fuel Cycle and Waste Management Division of the IAEA has been giving great attention to the collection, analysis and exchange of information in the field of reactor fuel technology. Most of these activities are being conducted in the framework of the International Working Group on Water Reactor Fuel Performance and Technology (IWGFPT). The purpose of this Advisory Group Meeting on Advanced Fuel Technology and Performance was to update and to continue the previous work, and to review the experience of advanced fuel technology, its performance with regard to all types of reactors and to outline the future trends on the basis of national experience and discussions during the meeting. As a result of the meeting a Summary Report was prepared which reflected the status of the advanced nuclear fuel technology up to 1990. The 10 papers presented by participants of this meeting are also published here. A separate abstract was prepared for each of these papers. Refs, figs and tabs

  12. Profile of functional limitations and task performance among people with early- and middle-stage Parkinson disease.

    Science.gov (United States)

    Schenkman, Margaret; Ellis, Terry; Christiansen, Cory; Barón, Anna E; Tickle-Degnen, Linda; Hall, Deborah A; Wagenaar, Robert

    2011-09-01

    Overall functional ability declines over time in people with Parkinson disease (PD). Established benchmarks are needed to allow clinicians and researchers to facilitate meaningful interpretation of data. The purposes of this study were: (1) to report typical values for standard measures of functional ability commonly used in intervention studies and clinical practice with individuals in the early and middle stages of PD and (2) to describe the profile of functional limitations using the Hoehn and Yahr (H&Y) stages of disease and Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. Cross-sectional data were obtained from 5 different studies. Three hundred thirty-nine patients were evaluated for disease severity (UPDRS motor score); functional capacity (Continuous Scale Physical Functional Performance Test [CS-PFP]); balance and gait (Functional Reach Test [FRT], Timed "Up & Go" Test [TUG], 360-degree turn, Six-Minute Walk Test [6MWT], and Two-Minute Walk Test); and basic functional activities (supine-to-stand task, stand-to-supine task, and functional axial rotation [FAR]). The mean UPDRS motor score for the sample was 39.2 (SD=12.93). At each stage of PD (from least to most involved), scores on functional measures indicated a significant and progressively reduced functional status. Limitations began early in the disease for the CS-PFP and FAR. Losses in performance were consistent across all stages of disease for the CS-PFP, FRT, 6MWT, and FAR. Several measures demonstrated meaningful losses of function only in later stages of disease. Findings extend current appreciation of functional limitations that begin early in PD and can guide the choice of functional outcome measures at different stages of disease severity. Data were obtained only from participants in H&Y stages 1 through 3 and only for some of the performance measures typically used. The findings demonstrate that functional loss occurs at different points in the disease process, depending on the

  13. The Impact of Expander Inflation/Deflation Status During Adjuvant Radiotherapy on the Complications of Immediate Two-Stage Breast Reconstruction.

    Science.gov (United States)

    Woo, Kyong-Je; Paik, Joo-Myeong; Bang, Sa Ik; Mun, Goo-Hyun; Pyon, Jai-Kyong

    2017-06-01

    The question of whether expander inflation/deflation status has any bearing on surgical complications in the setting of adjuvant radiation (XRT) has not been addressed. The objective of this study is to investigate whether the inflation/deflation status of the expander at the time of XRT is associated with complications in immediate two-stage expander-implant breast reconstruction. A retrospective review of 49 consecutive patients who underwent immediate two-stage expander-implant breast reconstruction and received post-mastectomy XRT was conducted. Full deflation of the expanders was performed in the deflation group (20 patients), while the expanders remained inflated in the inflation group at the time of XRT (29 patients). XRT-related complications of each stage of reconstructions were compared between the two groups, and multivariable regression analysis was performed to identify risk factors for XRT-related complications. Overall XRT-related complications (65.0 vs. 6.9%, p deflation group. The most common cause of reconstruction failure in the deflation group was failure to re-expand due to skin fibrosis and contracture. In multivariable analysis, deflation of expanders was a significant risk factor for overall complications (odds = 94.4, p = 0.001) and reconstruction failures (odds = 9.09, p = 0.022) of the first-stage reconstructions. Maximal inflation without deflation before XRT can be an option to minimize XRT-related complications and reconstruction failure of the first-stage reconstructions. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  14. The National Ignition Facility 2007 laser performance status

    Energy Technology Data Exchange (ETDEWEB)

    Haynam, C A; Sacks, R A; Wegner, P J; Bowers, M W; Dixit, S N; Erbert, G V; Heestand, G M; Henesian, M A; Hermann, M R; Jancaitis, K S; Manes, K R; Marshall, C D; Mehta, N C; Menapace, J; Nostrand, M C; Orth, C D; Shaw, M J; Sutton, S B; Williams, W H; Widmayer, C C [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550 (United States)], E-mail: haynam1@llnl.gov (and others)

    2008-05-15

    The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory contains a 192-beam 3.6 MJ neodymium glass laser that is frequency converted to 351nm light. It has been designed to support high energy density science (HEDS), including the demonstration of fusion ignition through Inertial Confinement. To meet this goal, laser design criteria include the ability to generate pulses of up to 1.8-MJ total energy at 351nm, with peak power of 500 TW and precisely-controlled temporal pulse shapes spanning two orders of magnitude. The focal spot fluence distribution of these pulses is conditioned, through a combination of special optics in the 1{omega} (1053 nm) portion of the laser (continuous phase plates), smoothing by spectral dispersion (SSD), and the overlapping of multiple beams with orthogonal polarization (polarization smoothing). In 2006 and 2007, a series of measurements were performed on the NIF laser, at both 1{omega} and 3{omega} (351 nm). When scaled to full 192-beam operation, these results lend confidence to the claim that NIF will meet its laser performance design criteria and that it will be able to simultaneously deliver the temporal pulse shaping, focal spot conditioning, peak power, shot-to-shot reproducibility, and power balance requirements of indirect-drive fusion ignition campaigns. We discuss the plans and status of NIF's commissioning, and the nature and results of these measurement campaigns.

  15. Effect of Habits and Nutritional Status on Clinical Grading and Histopathological Staging in Patients with Oral Sub Mucous Fibrosis

    Science.gov (United States)

    Lanke, Rama Brahmam; Shetty, Rakhith; Akifuddin, Syed; Sahu, Manish; Singh, Navneet; Kaur, Gagandeep; Goyal, Garish

    2015-01-01

    Background Oral submucous fibrosis (OSMF) is a chronic progressive debilitating disease affecting the oral, oropharyngeal and sometimes the oesophageal mucosa resulting in inability to eat due to burning, ulcers and stiffness. Aim The study was undertaken, to evaluate the correlation of clinical staging, histological grading and nutritional status using body mass index (BMI) with gutkha (habit) index in OSMF patients. Materials and Methods The study group comprised of 50 patients clinically diagnosed and histopathologically confirmed cases of OSMF. Habit (gutkha) index was calculated by multiplying duration and frequency. Body mass index was calculated by dividing weight in kilograms and height in centimetres of the patient. Results Male to female ratio was 2.8:1. Clinical grading increased with increase in gutkha index, patients with gutkha index 1-50, maximum were in mild stage; with gutkha index 51-100, maximum in moderate and patients with gutkha index 101-150, all were in severe stage. Histological staging showed direct correlation with gutkha index, it increased with increase in gutkha index with p <0.05. Site analysis showed that buccal mucosa and retromolar area were involved in all the patient and floor of mouth in 46% of patients Body mass index analysis revealed that out of 27 patients with moderate clinical staging 3 was underweight; out of 3 with severe clinical staging, 2 was underweight. Conclusion The duration and frequency of areca nut product use effects on the incidence and severity of OSMF and the patient becomes unable to eat due to burning, ulcers and inability to open mouth which affect the health of the individual. Thus it is important to access the nutritional status to improve the survival rate of patients. PMID:26557616

  16. Quality of life and performance status in patients with pancreatic and periampullary tumors

    International Nuclear Information System (INIS)

    Velanovich, V.; Wollner, I.

    2011-01-01

    The background of this study was to determine if pretreatment quality of life is associated with performance status in patients with pancreatic and periampullary tumors. Eighty consecutive patients evaluated for surgical treatment of pancreatic or periampullary tumors completed the social functioning SF-36, a generic quality of life instrument. This instrument measures 8 domains of quality of life: physical functioning (PF), role-physical (RP), role-emotional, bodily pain, vitality, mental health, social functioning, and general health (GH). The best possible score is 100 and the worst possible score is 0. Each patient was then assigned a Karnofsky performance score (KPS), with the best possible score of 100 (normal, no complaints, no evidence of disease) and worst score of 0 (dead). Data recorded included age, gender, pathology, stage, resection, use of chemotherapy, and radiation therapy. Statistical analysis was done using single and multiple linear regression analysis, correlation coefficients (r) and coefficient of determination (r 2 ). KPS was significantly associated with all domains of the SF-36 by single linear regression. By multiple linear regression, KPS was significantly associated with the PF domain (p 2 values) suggest that there are additional factors determining both quality of life and performance status in patients with pancreatic and periampullary tumors. (author)

  17. Hybrid maize breeding with doubled haploids: I. One-stage versus two-stage selection for testcross performance.

    Science.gov (United States)

    Longin, C Friedrich H; Utz, H Friedrich; Reif, Jochen C; Schipprack, Wolfgang; Melchinger, Albrecht E

    2006-03-01

    Optimum allocation of resources is of fundamental importance for the efficiency of breeding programs. The objectives of our study were to (1) determine the optimum allocation for the number of lines and test locations in hybrid maize breeding with doubled haploids (DHs) regarding two optimization criteria, the selection gain deltaG(k) and the probability P(k) of identifying superior genotypes, (2) compare both optimization criteria including their standard deviations (SDs), and (3) investigate the influence of production costs of DHs on the optimum allocation. For different budgets, number of finally selected lines, ratios of variance components, and production costs of DHs, the optimum allocation of test resources under one- and two-stage selection for testcross performance with a given tester was determined by using Monte Carlo simulations. In one-stage selection, lines are tested in field trials in a single year. In two-stage selection, optimum allocation of resources involves evaluation of (1) a large number of lines in a small number of test locations in the first year and (2) a small number of the selected superior lines in a large number of test locations in the second year, thereby maximizing both optimization criteria. Furthermore, to have a realistic chance of identifying a superior genotype, the probability P(k) of identifying superior genotypes should be greater than 75%. For budgets between 200 and 5,000 field plot equivalents, P(k) > 75% was reached only for genotypes belonging to the best 5% of the population. As the optimum allocation for P(k)(5%) was similar to that for deltaG(k), the choice of the optimization criterion was not crucial. The production costs of DHs had only a minor effect on the optimum number of locations and on values of the optimization criteria.

  18. Subjective global assessment of nutritional status of patients with chronic renal insufficiency and end stage renal disease on dialysis.

    Science.gov (United States)

    Tapiawala, Shruti; Vora, H; Patel, Zamrud; Badve, S; Shah, B

    2006-12-01

    (1)To assess the nutritional status of chronic renal insufficiency (CRI) and dialysis patients using the subjective global assessment (SGA) method. (2) To validate SGA in assessing the nutritional status of this group of patients. The nutritional status of 81 patients was evaluated using dietary recall, anthropometry, biochemical parameters and SGA. There were 51 males and 30 females. Their mean +/- SD age was 53.8 +/- 14.3 years. There were 27 patients with (CRI) on conservative management, 38 patients with end stage renal disease (ESRD) on maintenance hemodialysis (HD) and 16 patients with ESRD on continuous ambulatory peritoneal dialysis (CAPD). SGA was done using seven variables derived from medical history and physical examination. Each variable was scored from 1-7 depending on the severity. The SGA scores were correlated with the standard methods. Thirteen (48%) patients with CRI, 22 (58%) patients on HD and 8 (50%) patients on CAPD were malnourished. It was seen that the dietary protein & calorie intake and serum albumin level did not correlate well with the SGA scores. The anthropometric measures correlated with the SGA scores (Skinfolds and SGA r = 0.2, MAC and SGA r = 0.5 and MAMC and SGA r = 0.5). Malnutrition is an important complication in CRI patients and ESRD patients on dialysis. SGA is a reliable method of assessing nutritional status. Most important is the fact that it can detect the changing trend of nutritional status, which may be missed by one-time anthropometry and biochemical methods.

  19. Improvement in performance status after erythropoietin treatment in lung cancer patients undergoing concurrent chemoradiotherapy

    International Nuclear Information System (INIS)

    Casas, Francesc; Vinolas, Nuria; Ferrer, Ferran; Farrus, Blanca; Gimferrer, Josep Maria; Agusti, Carles; Belda, Josep; Luburich, Patricio

    2003-01-01

    Purpose: A prospective Phase II trial was carried out to evaluate the effectiveness of erythropoietin in improving or maintaining performance status as determined by the Karnofsky performance status (KPS) score and hemoglobin (Hb) levels in lung cancer patients treated with concurrent chemoradiation (CH-RT). Methods and Materials: A total of 51 patients with lung cancer (11 with small-cell, limited stage and 40 with non-small-cell disease, 17 with Stage IIIA and 23 with Stage IIIB), who underwent three different concurrent CH-RT protocols were enrolled. Baseline Hb and KPS values were recorded, as were the nadir Hb and KPS values before concurrent CH-RT. The final Hb and KPS values were recorded the last week of concurrent CH-RT. An Hb level of ≤11 g/dL before concurrent CH-RT was required before receiving erythropoietin. Prognostic factors for KPS improvement and survival were assessed by univariate and multivariate studies. Results: Of the 51 patients, 47 (92.3%) were men (mean age 63.6 years, range 40-75). The median baseline KPS score was 80, and the mean baseline Hb was 12.2 ± 1.76 g/dL (range 9-16.9). The mean nadir and final Hb value was 9.98±0.67 g/dL (range 8.6-11) and 11.33±1.59 g/dL (range 6.9-14.4), respectively. A significant increase was seen in the Hb and KPS score (p<0.05) in the final measurements. Differences were found between the final and nadir Hb in the predictive value for differences in performance status (p=0.001). On univariate study, pathologic findings (p=0.0234), weight loss (p=0.0049), baseline Hb (p=0.0057), and final Hb improvement (p=0.0237) were prognostic factors for survival. Nadir Hb (p=0.027), final Hb improvement (p=0.0069), pathologic findings (p = 0.0006), and weight loss (p=0.0001) had significant prognostic value for survival in multivariate analysis. Conclusion: In this study, erythropoietin appears to have a significant, beneficial impact on the KPS and Hb of patients undergoing concurrent CH-RT

  20. Hydration status of patients with end-stage renal disease after kidney transplantation.

    Science.gov (United States)

    Gueutin, Victor; Ficheux, Maxence; Châtelet, Valérie; Lecouf, Angélique; Henri, Patrick; Hurault de Ligny, Bruno; Ryckelynck, Jean-Philippe; Lobbedez, Thierry

    2011-01-01

    This study was carried out to estimate the modification of hydration status within the first three months of renal transplantation. Fifty patients who underwent a first kidney allograft were prospectively followed for three months after renal transplantation to assess hydration status by bioimpedance spectroscopy. Two hours before the transplant procedure, 10/42 (23.8%) patients were overhydrated. Two days after surgery, 32/40 (80.0%) patients were overhydrated and at three months, 14/27 (51.9%) patients remained fluid-overloaded. Peritoneal dialysis (PD) patients had a lower hydration status (-0.60 L) than hemodialysis (HD) patients (0.70 L; p hydration status before transplantation (p = 0.031). At three months, 12/14 of the overhydrated patients had a creatinine clearance between 30 and 60 mL/min/1.73 m(2) . Patients receiving a first kidney transplant frequently have a hydration disorder. Transplantation is associated with increased hydration status, which seems to persist if DGF or SGF occurs. © 2011 John Wiley & Sons A/S.

  1. The SSG Wave Energy Converter: Performance, Status and Recent Developments

    Directory of Open Access Journals (Sweden)

    Mariano Buccino

    2012-01-01

    Full Text Available The Sea-wave Slot-cone Generator (SSG is a Wave Energy Converter based on the wave overtopping principle; it employs several reservoirs placed on top of each other, in which the energy of incoming waves is stored as potential energy. Then, the captured water runs through turbines for electricity production. The system works under a wide spectrum of different wave conditions, giving a high overall efficiency. It can be suitable for shoreline and breakwater applications and presents particular advantages, such as sharing structure costs, availability of grid connection and recirculation of water inside the harbor, as the outlet of the turbines is on the rear part of the system. Recently, plans for the SSG pilot installations are in progress at the Svaaheia site (Norway, the port of Hanstholm (Denmark and the port of Garibaldi (Oregon, USA. In the last-mentioned two projects, the Sea-wave Slot-cone Generator technology is integrated into the outer harbor breakwater and jetty reconstruction projects. In the last years extensive studies have been performed on the hydraulic and the structural response of this converter, with the aim of optimizing the design process. The investigations have been conducted by physical model tests and numerical simulations and many results have been published on both conference proceedings and journals. The main scope of this paper is reviewing the most significant findings, to provide the reader with an organic overview on the present status of knowledge.

  2. Sentinel-5 instrument: status of design, performance, and development

    Science.gov (United States)

    Gühne, T.; Keim, C.; Bartsch, P.; Weiß, S.; Melf, M.; Seefelder, W.

    2017-09-01

    The Sentinel-5 instrument is currently under development by a consortium led by Airbus Defence and Space in the frame of the European Union Copernicus program. It is a customer furnished item to the MetOp Second Generation satellite platform, which will provide operational meteorological data for the coming decades. Mission objective of the Sentinel-5 is to monitor the composition of the Earth atmosphere for Copernicus Atmosphere Services by taking measurements of trace gases and aerosols impacting air quality and climate with high resolution and daily global coverage. Therefore the Sentinel-5 provides five dispersive spectrometers covering the UV-VIS (270…500 nm), NIR (685 …773 nm) and SWIR (1590…1675 and 2305…2385 nm) spectral bands with resolutions <=1nm. Spatially the Sentinel-5 provides a 108° field of view with a ground sampling of 7.5 x 7 km2 at Nadir. The development program is post PDR and the build-up of the industrial team is finalised. We report on the instrument architecture and design derived from the driving requirements, the predicted instrument performance, and the general status of the program.

  3. Multipurpose Rotating Rake Arrays for Integrated Inlet and Fan Stage Performance Measurement

    Science.gov (United States)

    Wolter, John D.

    2017-01-01

    Low-pressure-ratio fan stage performance measurement requires precise measurement of conditions upstream and downstream of the fan stage. This presentation will discuss the rotating rake arrays used for the recent Boundary Layer Ingesting Inlet-Distortion-Tolerant Fan experiment in the NASA Glenn 8 by 6 foot wind tunnel. To achieve precise measurements, simulations of the rake sampling from pre-test CFD (Computerized Fluid Dynamics) solutions were used to optimize the number and locations of rake instruments.

  4. Is the technical performance of young soccer players influenced by hormonal status, sexual maturity, anthropometric profile, and physical performance?

    Directory of Open Access Journals (Sweden)

    Alexandre Moreira

    2017-12-01

    Full Text Available The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs. Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale, and physical performance tests (Yo-Yo and vertical jumps were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs. Principal component analyses identified four technical actions of importance: total number of passes, effectiveness, goal attempts, and total tackles. A multivariate canonical correlation analysis was then employed to verify the prediction of a multiple dependent variables set (composed of four technical actions from an independent set of variables, composed of testosterone concentration, stage of pubic hair and genitalia development, vertical jumps and Yo-Yo performance. A moderate-to-large relationship between the technical performance set and the independent set was observed. The canonical correlation was 0.75 with a canonical R2 of 0.45. The highest structure coefficient in the technical performance set was observed for tackles (0.77, while testosterone presented the highest structure coefficient (0.75 for the variables of the independent set. The current data suggest that the selected independent set of variables might be useful in predicting SSG performance in young soccer players. Coaches should be aware that physical development plays a key role in technical performance to avoid decision-making mistakes during the selection of young players.

  5. Is the technical performance of young soccer players influenced by hormonal status, sexual maturity, anthropometric profile, and physical performance?

    Science.gov (United States)

    Moreira, Alexandre; Massa, Marcelo; Thiengo, Carlos R; Rodrigues Lopes, Rafael Alan; Lima, Marcelo R; Vaeyens, Roel; Barbosa, Wesley P; Aoki, Marcelo S

    2017-12-01

    The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs). Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale), and physical performance tests (Yo-Yo and vertical jumps) were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs. Principal component analyses identified four technical actions of importance: total number of passes, effectiveness, goal attempts, and total tackles. A multivariate canonical correlation analysis was then employed to verify the prediction of a multiple dependent variables set (composed of four technical actions) from an independent set of variables, composed of testosterone concentration, stage of pubic hair and genitalia development, vertical jumps and Yo-Yo performance. A moderate-to-large relationship between the technical performance set and the independent set was observed. The canonical correlation was 0.75 with a canonical R 2 of 0.45. The highest structure coefficient in the technical performance set was observed for tackles (0.77), while testosterone presented the highest structure coefficient (0.75) for the variables of the independent set. The current data suggest that the selected independent set of variables might be useful in predicting SSG performance in young soccer players. Coaches should be aware that physical development plays a key role in technical performance to avoid decision-making mistakes during the selection of young players.

  6. Is the technical performance of young soccer players influenced by hormonal status, sexual maturity, anthropometric profile, and physical performance?

    Science.gov (United States)

    Moreira, Alexandre; Massa, Marcelo; Thiengo, Carlos R.; Rodrigues Lopes, Rafael Alan; Lima, Marcelo R.; Vaeyens, Roel; Barbosa, Wesley P.

    2017-01-01

    The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs). Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale), and physical performance tests (Yo-Yo and vertical jumps) were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs. Principal component analyses identified four technical actions of importance: total number of passes, effectiveness, goal attempts, and total tackles. A multivariate canonical correlation analysis was then employed to verify the prediction of a multiple dependent variables set (composed of four technical actions) from an independent set of variables, composed of testosterone concentration, stage of pubic hair and genitalia development, vertical jumps and Yo-Yo performance. A moderate-to-large relationship between the technical performance set and the independent set was observed. The canonical correlation was 0.75 with a canonical R2 of 0.45. The highest structure coefficient in the technical performance set was observed for tackles (0.77), while testosterone presented the highest structure coefficient (0.75) for the variables of the independent set. The current data suggest that the selected independent set of variables might be useful in predicting SSG performance in young soccer players. Coaches should be aware that physical development plays a key role in technical performance to avoid decision-making mistakes during the selection of young players. PMID:29472732

  7. [METABOLIC STATUS OF PATIENTS OF DIFFERENT AGE GROUPS ON THE STAGES OF OSTEOARTHRITIS].

    Science.gov (United States)

    Stogov, M V; Ovchinnikov, E N; Sazonova, N V

    2015-01-01

    This study investigated the biochemical parameters of blood and urine in patients with osteoarthritis in the stages of the pathological process in different age groups. The patients of all age groups in the stages of osteoarthritis demonstrated metabolic acidosis, activation of the antioxidant system and increase in acute phase proteins. In addition to the total for all age groups metabolic shifts the characteristic age-related changes were observed: activated reaction of lipid peroxidation in middle-aged patients and negative calcium balance, with increasing energy metabolism disorders in elderly patients.

  8. Degenerative neuronal changes in the rat thalamus induced by status epilepticus at different developmental stages

    Czech Academy of Sciences Publication Activity Database

    Druga, Rastislav; Mareš, Pavel; Otáhal, Jakub; Kubová, Hana

    2005-01-01

    Roč. 63, č. 1 (2005), s. 43-65 ISSN 0920-1211 R&D Projects: GA ČR(CZ) GA309/01/0285 Institutional research plan: CEZ:AV0Z5011922 Keywords : status epilepticus * lithium pilocarpine * thalamus Subject RIV: FH - Neurology Impact factor: 2.663, year: 2005

  9. Vitamins K and D status in patients with stages 3-5 chronic kidney disease

    Science.gov (United States)

    Background and Objectives: Vitamin K, vitamin K-dependent (VKD) proteins and vitamin D may be involved in the regulation of calcification in chronic kidney disease (CKD). Design, setting, participants and measurements: Vitamin K and D status was measured as dietary intake, plasma phylloquinone, se...

  10. Trait anxiety predicts disease-specific health status in early-stage breast cancer patients

    NARCIS (Netherlands)

    van Esch, Lotje; Roukema, Jan A.; van der Steeg, Alida F. W.; de Vries, Jolanda

    2011-01-01

    The objectives of this study were to examine the differences in health status (HS) of women with breast cancer (BC) at different moments in time, and between women scoring high and not high on trait anxiety, and to identify possible predictors of HS 6 and 12 months after surgery. Patients (N = 223)

  11. Reproductive performance and nutritional status of Holstein cows in Brazil

    International Nuclear Information System (INIS)

    Meirelles, C.F.; Vitti, D.M.S.S.; Abdalla, A.L.

    1990-01-01

    Reproductive performance and nutritional status were assessed in Holstein cows from two dairy herds in Sao Paulo State, Brazil. In the first herd (good management, G), concentrate was fed individually to cows, complete records were kept, veterinary services were provided as necessary and the standard of husbandry practices was good. In the second herd (fair management, F), veterinary services were used only occasionally, the concentrate fed was divided equally among lactating cows and the standard of husbandry practices was only fair. Haemoglobin, haematocrit, glucose, total protein and phosphorus were measured in blood collected at various times after calving. There were no statistical differences between the blood parameters in the two herds except for inorganic phosphorus which differed significantly between farms (P < 0.01). Only plasma glucose had a significant (P < 0.01) effect on the time required by the animals to initiate post-partum ovarian activity. The proportion of cows ovulating by day 60 was 75% in herd G versus 53% in herd F (P < 0.01); by day 100 the values were 82% in herd G and 70% in herd F (P < 0.01). Calving intervals were 12.7 and 13.2 months for herds G and F respectively, suggesting comparable reproductive efficiency. However, only 1 of the 28 cows in herd G was open more than 365 days after calving, as opposed to 5 of the 30 cows in herd F. When a value of 365 open days was given for these non-pregnant cows, the average days open for the herds were then 123 and 154 days for herds G and F respectively, indicating a decided production advantage in favour of the better managed herd. (author). 16 refs, 1 fig., 2 tabs

  12. Payload Performance Analysis for a Reusable Two-Stage-to-Orbit Vehicle

    Science.gov (United States)

    Tartabini, Paul V.; Beaty, James R.; Lepsch, Roger A.; Gilbert, Michael G.

    2015-01-01

    This paper investigates a unique approach in the development of a reusable launch vehicle where, instead of designing the vehicle to be reusable from its inception, as was done for the Space Shuttle, an expendable two stage launch vehicle is evolved over time into a reusable launch vehicle. To accomplish this objective, each stage is made reusable by adding the systems necessary to perform functions such as thermal protection and landing, without significantly altering the primary subsystems and outer mold line of the original expendable vehicle. In addition, some of the propellant normally used for ascent is used instead for additional propulsive maneuvers after staging in order to return both stages to the launch site, keep loads within acceptable limits and perform a soft landing. This paper presents a performance analysis that was performed to investigate the feasibility of this approach by quantifying the reduction in payload capability of the original expendable launch vehicle after accounting for the mass additions, trajectory changes and increased propellant requirements necessary for reusability. Results show that it is feasible to return both stages to the launch site with a positive payload capability equal to approximately 50 percent of an equivalent expendable launch vehicle. Further discussion examines the ability to return a crew/cargo capsule to the launch site and presents technical challenges that would have to be overcome.

  13. Mycorrhizal status of plants in two successional stages on spoil heaps from fireloam mining in Lower Silesia (SW Poland

    Directory of Open Access Journals (Sweden)

    Dorota Kasowska

    2014-01-01

    Full Text Available The mycorrhizal status of two plant communities representing an initial stage (1-2 year-old and a 8-9-year-old stage of succession on spoil heaps from fireloam mining in Lower Silesia, Poland, was determined. In the initial stage, the mycorrhizal structures were not observed in 39% of the investigated species; they were members of the Polygonaceae, Chenopodiaceae and Poaceae families. The relative cover of non-mycorrhizal plants exceeded 50% and the major role was played by the Polygonum aviculare population, which predominated the whole community. Mycorrhizal species (arbuscular mycorrhizae contributed to 61 % of the composition of the initial phyto-coenosis. The most numerous taxa were those with 20-40% of the root length colonized, with a small number of arbuscules (0.2-3.1% of the root length containig arbuscules and no vesicles. In the advanced stage of succession, mycorrhizal plants definitely dominated and the major role was played by the Tussilago farfara population. Compared with the initial stage, the later one also harboured more plants with mycorrhizas occupied >40% of the root length, as well as containing numerous arbuscules (>20% of the root length and vesicles. The non-mycorrhizal species, i.e., Equisetum arvense and Poa compressa, represented 11 % o': the community composition and their relative cover amounted to 3%. Despite the relatively frequent occurrence of the arbuscular mycorrhizae in the initial stage of succession, the qualitative properties of the colonization indicated a low effectiveness of symbiosis. This could be caused by the lack of adaptation of the fungal symbiont to the edaphic conditions which were changed after disturbance.

  14. Vitamin status and needs for people with stages 3-5 chronic kidney disease.

    Science.gov (United States)

    Steiber, Alison L; Kopple, Joel D

    2011-09-01

    Patients with chronic kidney disease (CKD) often experience a decline in their nutrient intake starting at early stages of CKD. This reduction in intake can affect both energy-producing nutrients, such as carbohydrates, proteins, and fats, as well as vitamins, minerals, and trace elements. Knowledge of the burden and bioactivity of vitamins and their effect on the health of the patients with CKD is very incomplete. However, without sufficient data, the use of nutritional supplements to prevent inadequate intake may result in either excessive or insufficient intake of micronutrients for people with CKD. The purpose of this article is to briefly summarize the current knowledge regarding vitamin requirements for people with stages 3, 4, or 5 CKD who are not receiving dialysis. Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  15. Influence of slot width on the performance of multi-stage overtopping wave energy converters

    Directory of Open Access Journals (Sweden)

    Sirirat Jungrungruengtaworn

    2017-11-01

    Full Text Available A two-dimensional numerical investigation is performed to study the influence of slot width of multi-stage stationary floating overtopping wave energy devices on overtopping flow rate and performance. The hydraulic efficiency based on captured crest energy of different device layouts is compared with that of single-stage device to determine the effect of the geometrical design. The results show optimal trends giving a huge increase in overtopping energy. Plots of efficiency versus the relative slot width show that, for multi-stage devices, the greatest hydraulic efficiency is achieved at an intermediate value of the variable within the parametric range considered, relative slot width of 0.15 and 0.2 depending on design layouts. Moreover, an application of adaptive slot width of multi-stage device is investigated. The numerical results show that the overall hydraulic efficiency of non-adaptive and adaptive slot devices are approximately on par. The effect of adaptive slot width on performance can be negligible. Keywords: Wave energy converter, Overtopping, Multi-stage, Slot width

  16. Benchmarking and performance enhancement framework for multi-staging object-oriented languages

    Directory of Open Access Journals (Sweden)

    Ahmed H. Yousef

    2013-06-01

    Full Text Available This paper focuses on verifying the readiness, feasibility, generality and usefulness of multi-staging programming in software applications. We present a benchmark designed to evaluate the performance gain of different multi-staging programming (MSP languages implementations of object oriented languages. The benchmarks in this suite cover different tests that range from classic simple examples (like matrix algebra to advanced examples (like encryption and image processing. The benchmark is applied to compare the performance gain of two different MSP implementations (Mint and Metaphor that are built on object oriented languages (Java and C# respectively. The results concerning the application of this benchmark on these languages are presented and analysed. The measurement technique used in benchmarking leads to the development of a language independent performance enhancement framework that allows the programmer to select which code segments need staging. The framework also enables the programmer to verify the effectiveness of staging on the application performance. The framework is applied to a real case study. The case study results showed the effectiveness of the framework to achieve significant performance enhancement.

  17. Prevalence and Predictors of Neoadjuvant Therapy for Stage IIIA Non-Small Cell Lung Cancer in the National Cancer Database: Importance of Socioeconomic Status and Treating Institution

    International Nuclear Information System (INIS)

    Sher, David J.; Liptay, Michael J.; Fidler, Mary Jo

    2014-01-01

    Purpose: The optimal locoregional therapy for stage IIIA non-small cell lung cancer (NSCLC) is controversial, with definitive chemoradiation therapy (CRT) and neoadjuvant therapy followed by surgery (NT-S) serving as competing strategies. In this study, we used the National Cancer Database to determine the prevalence and predictors of NT in a large, modern cohort of patients. Methods and Materials: Patients with stage IIIA NSCLC treated with CRT or NT-S between 2003 and 2010 at programs accredited by the Commission on Cancer were included. Predictors were categorized as clinical, time/geographic, socioeconomic, and institutional. In accord with the National Cancer Database, institutions were classified as academic/research program and as comprehensive and noncomprehensive community cancer centers. Logistic regression and random effects multilevel logistic regression were performed for univariable and multivariable analyses, respectively. Results: The cohort consisted of 18,581 patients, 3,087 (16.6%) of whom underwent NT-S (10.6% induction CRT, 6% induction chemotherapy). The prevalence of NT-S was constant over time, but there were significant relative 31% and 30% decreases in pneumonectomy and right-sided pneumonectomy, respectively, over time (P trend <.02). In addition to younger age, lower T stage, and favorable comorbidity score, indicators of higher socioeconomic status were strong independent predictors of NT-S, including white race, higher income, and private/managed insurance. The type of institution (academic/research program vs comprehensive or noncomprehensive community cancer centers, odds ratio 1.54 and 2.08, respectively) strongly predicted NT-S, but treatment volume did not. Conclusions: Neoadjuvant therapy followed by surgery was an uncommon treatment approach in Commission on Cancer programs, and the prevalence of postinduction pneumonectomy decreased over time. Higher socioeconomic status and treatment at academic institutions were significant

  18. The Prognostic Effect of American Joint Committee on Cancer Staging and Genetic Status in Patients With Choroidal and Ciliary Body Melanoma

    DEFF Research Database (Denmark)

    Bagger, Mette; Andersen, Morten T; Andersen, Klaus K

    2015-01-01

    PURPOSE: To evaluate the prognostic effect of a combination of American Joint Committee on Cancer (AJCC) staging (7th edition) and genetic status in patients with posterior uveal melanoma. METHODS: A consecutive cohort of 153 patients with posterior uveal melanoma treated at Copenhagen University...... prognostic effects of AJCC staging and cytogenetic changes were evaluated by cumulative incidence curves and Cox proportional hazard models. RESULTS: An overall 5-year survival rate of 62% (95% confidence interval [CI]: 0.50-0.73) was observed. A normal genetic status of chromosomes 3 and 8, as found in 42...... patients (30%), minimized the additional prognostic effect of AJCC staging. The frequency of tumors with normal genetic status decreased with increasing AJCC stage. Both AJCC stage III (hazard ratio [HR]: 11.0, 95% CI: 1.4-85.6) and abnormal copy number of chromosomes 3 (HR: 6.3, 95% CI: 1.4-28.3) and 8...

  19. LONGITUDINAL STUDY OF REPEATED SPRINT PERFORMANCE IN YOUTH SOCCER PLAYERS OF CONTRASTING SKELETAL MATURITY STATUS

    Directory of Open Access Journals (Sweden)

    João Valente-dos-Santos

    2012-09-01

    Full Text Available The purpose of the study was to evaluate the developmental changes in performance in a repeated-sprint ability (RSA test in young soccer players of contrasting maturity status. A total of 83 regional level Portuguese youth soccer players, aged 11- 13 years at baseline was assessed annually. Stature, body mass, 7x34.2-m sprint protocol (25-s active recovery, 20-m multi-stage continuous shuttle endurance run and counter-movement jump (CMJ without the use of the arms were measured. Fat-free mass (FFM was determined by age and gender- specific formulas. Developmental changes in total sprint time across ages were predicted using multilevel modeling. Corresponding measurements were performed on an independent cross-sectional subsample of 52 youth soccer players 11-17 years to evaluate the predictive model. CA, CA2, maturational status (SA-CA, body size (mass and stature, FFM, aerobic endurance, lower limb explosive strength and annual volume training significantly improved the statistical fit of the RSA multilevel model. In 'late' maturing athletes, the best model for predicting change in RSA was expressed by the following equation: 86.54 - 2.87 x CA + 0.05 x CA2 - 0.25 x FFM + 0.15 x body mass + 0.05 x stature - 0.05 x aerobic endurance - 0.09 x lower limb explosive strength - 0.01 x annual volume training. The best fitting models for players who were 'on time' and 'early' maturing were identical to the best model for late maturing players, less 0.64 seconds and 1.74 seconds, respectively. Multilevel modeling provided performance curves that permitted the prediction of individual RSA performance across adolescent years in regional level soccer players

  20. Effects of Endwall Geometry and Stacking on Two-Stage Supersonic Turbine Performance

    Science.gov (United States)

    Dorney, Daniel J.; Griffin, Lisa W.; Huber, Frank W.; Sondak, Douglas L.; Turner, Jim (Technical Monitor)

    2002-01-01

    The drive towards high-work turbines has led to designs which can be compact, transonic, supersonic, counter rotating, or use a dense drive gas. These aggressive designs can lead to strong secondary flows and airfoil flow separation. In many cases the secondary and separated flows can be minimized by contouring the hub/shroud endwalls and/or modifying the airfoil stacking. In this study, three-dimensional unsteady Navier-Stokes simulations were performed to study three different endwall shapes between the first-stage vanes and rotors, as well as two different stackings for the first-stage vanes. The predicted results indicate that changing the stacking of the first-stage vanes can significantly impact endwall separation (and turbine performance) in regions where the endwall profile changes.

  1. Dietary Intake, Nutritional Status, and Body Composition in Children With End-Stage Kidney Disease on Hemodialysis or Peritoneal Dialysis.

    Science.gov (United States)

    Pontón-Vázquez, Consuelo; Vásquez-Garibay, Edgar Manuel; Hurtado-López, Erika Fabiola; de la Torre Serrano, Adriana; García, Germán Patiño; Romero-Velarde, Enrique

    2017-05-01

    This study aimed to demonstrate that dietary intake, anthropometric indicators, and body composition in children with end-stage kidney disease differs between those on peritoneal dialysis (PD) and those on hemodialysis (HD). This was a cross-sectional and consecutive study that included 55 children and adolescents with end-stage kidney disease who were undergoing replacement therapy (22 PD patients and 33 HD patients). Two 24-hour dietary recall surveys were conducted for each patient. Anthropometric, biochemical, and body composition indicators were estimated. A Student's t-test and a Mann-Whitney U test were used for the parametric variables, whereas association tests were estimated for the nonparametric variables (i.e., χ 2 , Fisher exact test, and odds ratio). Regression models were designed to predict dietary intake on anthropometric and body composition indicators. The mid-upper arm circumference was greater on the patients undergoing HD than on the PD patients (odds ratio = 15.8 [95% confidence interval (CI): 2.9, 85.1], P nutritional status in children on PD and 28% to 60% in children on HD. Nutritional status is affected in most patients on dialysis treatment, which differs significantly among those who are undergoing PD or HD. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  2. Do School Leaders Have a Shelf Life? Career Stages and Headteacher Performance

    Science.gov (United States)

    Earley, Peter; Weindling, Dick

    2007-01-01

    This article explores several issues about school leaders, career stages and performance. It draws upon various pieces of research, including the longitudinal study of secondary headteachers which began in the early 1980s at the National Foundation for Educational Research (NFER), to raise some key issues about headteachers' careers, the various…

  3. Quadriceps strength, inter-extremity difference (IED) and joint status in adult persons with severe haemophilia in different age stages.

    Science.gov (United States)

    Brunner, A; Stäuber, F; Göhler, S; Czepa, D; Krüger, S; Wendel, M; Seuser, A; Hilberg, T

    2013-03-01

    Quadriceps weakness seems to be a hallmark in adult persons with severe haemophilia (PWH). The purpose of this study was to compare PWH and non-haemophilic controls in different age stages with reference to joint status and quadriceps strength. Further aims were to examine the extent of strength-specific inter-extremity-difference (IED) and the prevalence of abnormal IED (AIED). A total of 106 adults with severe haemophilia (H) and 80 controls (C) had undergone an orthopaedic examination for classification of knee and ankle status using the WFH score. Quadriceps strength was evaluated unilaterally as well as bilaterally with a knee extensor device. Each group was divided into four age-related subgroups (HA/CA: 18-29, HB/CB: 30-39, HC/CC: 40-49, HD/CD: 50-70; in years). H presented a worse knee and ankle status than C indicated by higher WFH scores (P age-matched subgroups only HB showed higher knee scores than CB (P age-matched controls (P age in H. We discovered an AIED in 35% of H. These findings highlight the importance for the early implementation of preventive and rehabilitative muscle training programmes in the comprehensive treatment of PWH. © 2012 Blackwell Publishing Ltd.

  4. Maternal selenium-supplementation at various stages of periconception period: influence on murine blastocyst morphology and implantation status

    Directory of Open Access Journals (Sweden)

    Mark Anthony C. Mamon

    2017-04-01

    Full Text Available Abstract Background Selenium is one of the trace minerals whose deficiency is known to lead to complications of female reproduction. The identified gaps in researches regarding selenium and pregnancy include optimizing the dosage of selenium supplementation, timing of supplementation, finding the best form and type of selenium, and selenium administration combined with other antioxidants. Hence, this study was conceptualized to address one of the identified gaps, that is, to find out the best timing of selenium administration around the time of pregnancy. Specifically, this study aimed to assess the effects of maternal Selenium-supplementation, administered at various stages of periconception period, on murine blastocyst morphology, percent occurrence of good quality blastocysts, and implantation status. Methods ICR female mice were randomly assigned into the unsupplemented group (Group I receiving basal diet without selenium, and treatment groups given with 3.0 μg selenium-supplement per day during pregestation only (Group II, pregestation-throughout-gestation (Group III and gestation only (Group IV. Both blastocyst morphology and implantation status were assessed. Results The morphometric measurements of blastocysts appeared to be unaffected by selenium-supplementation at different stages of periconception. Selenium-supplementation at pregestation only (Group II and gestation only (Group IV produced higher percent occurrence of good quality blastocysts and lower percent pre-implantation loss than Group III. Among all the treatment groups, Group III (Selenium-supplementation during pregestation-to-gestation yielded the lowest quality blastocysts and highest percent pre-implantation loss. Conclusion Maternal selenium-supplementation during pregestation and gestation stages of the periconception period yielded a high percent occurrence of good quality blastocysts and pre-implantation success.

  5. Association of serum ferritin levels with immunological status and clinical staging of HIV patients: a retrospective study

    Science.gov (United States)

    Saragih, R. H.; Mardia, A. I.; Purba, G. C. F.; Syahrini, H.

    2018-03-01

    Serum ferritin has long known as an acute phase reactant during inflammation. It works as an oxidative stress marker beside its role in the storage of intracellular iron. The increase of serum ferritin levels (SFL) has been reported found in HIV patients. It remains unclear though whether it causes, or is the cause, to the progressivity of the disease. The purpose of this study was to find the association between the SFL and the progressivity of the HIV disease. A retrospective study of 91 patients was carried out at the Haji Adam Malik Central General Hospital. All of the study population were HIV positive inpatients admitted from January to December 2016. The data needed to be all obtained from the patient’s medical records. The WHO Clinical Staging System was used to assess the HIV clinical staging. An inverse relationship was found between the SFL with the immunological status of the HIV patients (r=-0.213) based on their CD4+ count. There was no association found between the SFL with the clinical staging of the HIV patients (p=0.953). The elevated SFL is a feature found in HIV-diagnosed patients with the low CD4+ count, and it affects the progressivity of the disease.

  6. Water status and associated processes mark critical stages in pollen development and functioning

    Science.gov (United States)

    Firon, Nurit; Nepi, Massimo; Pacini, Ettore

    2012-01-01

    Background The male gametophyte developmental programme can be divided into five phases which differ in relation to the environment and pollen hydration state: (1) pollen develops inside the anther immersed in locular fluid, which conveys substances from the mother plant – the microsporogenesis phase; (2) locular fluid disappears by reabsorption and/or evaporation before the anther opens and the maturing pollen grains undergo dehydration – the dehydration phase; (3) the anther opens and pollen may be dispersed immediately, or be held by, for example, pollenkitt (as occurs in almost all entomophilous species) for later dispersion – the presentation phase; (4) pollen is dispersed by different agents, remaining exposed to the environment for different periods – the dispersal phase; and (5) pollen lands on a stigma and, in the case of a compatible stigma and suitable conditions, undergoes rehydration and starts germination – the pollen–stigma interaction phase. Scope This review highlights the issue of pollen water status and indicates the various mechanisms used by pollen grains during their five developmental phases to adjust to changes in water content and maintain internal stability. Conclusions Pollen water status is co-ordinated through structural, physiological and molecular mechanisms. The structural components participating in regulation of the pollen water level, during both dehydration and rehydration, include the exine (the outer wall of the pollen grain) and the vacuole. Recent data suggest the involvement of water channels in pollen water transport and the existence of several molecular mechanisms for pollen osmoregulation and to protect cellular components (proteins and membranes) under water stress. It is suggested that pollen grains will use these mechanisms, which have a developmental role, to cope with environmental stress conditions. PMID:22523424

  7. Short-term outcomes and nutritional status after laparoscopic subtotal gastrectomy with a very small remnant stomach for cStage I proximal gastric carcinoma.

    Science.gov (United States)

    Furukawa, Haruna; Kurokawa, Yukinori; Takiguchi, Shuji; Tanaka, Koji; Miyazaki, Yasuhiro; Makino, Tomoki; Takahashi, Tsuyoshi; Yamasaki, Makoto; Nakajima, Kiyokazu; Mori, Masaki; Doki, Yuichiro

    2017-08-20

    Total or proximal gastrectomy is usually performed for early proximal gastric carcinoma, but the optimal type of gastrectomy is still unknown. We evaluated short-term outcomes and nutritional status after laparoscopic subtotal gastrectomy (LsTG) in comparison with laparoscopic total gastrectomy (LTG) and laparoscopic proximal gastrectomy (LPG). We analyzed 113 patients who underwent LsTG (n = 38), LTG (n = 48), or LPG (n = 27) for cStage I gastric cancer located in the upper third of the stomach. Postoperative morbidities, nutritional status including body weight, serum albumin, hemoglobin, the prognostic nutritional index (PNI), and endoscopic findings at 1 year after surgery were compared between LsTG and both LTG and LPG. Operation time and intraoperative blood loss were similar among the three groups. The incidence of postoperative morbidities was lower in LsTG than in LTG. The degree of body weight loss was significantly smaller in LsTG than in LTG at 6 and 12 months. At 12 months, LsTG resulted in better serum albumin and PNI than LPG, and better hemoglobin than LTG. Endoscopic examination demonstrated that one LsTG patient and two LPG patients had reflux esophagitis. Remnant gastritis was observed more frequently in LPG than in LsTG. No LsTG patient had bile reflux, although it was observed in four LPG patients. LsTG with a very small remnant stomach had favorable short-term outcomes and nutritional status compared with LTG and LPG, so it may be a better treatment option for cStage I proximal gastric carcinoma.

  8. Relationship between Nutritional Status and Gastrointestinal Symptoms in Geriatric Patients with End-Stage Renal Disease on Dialysis.

    Science.gov (United States)

    Carrera-Jiménez, Dinorah; Miranda-Alatriste, Paola; Atilano-Carsi, Ximena; Correa-Rotter, Ricardo; Espinosa-Cuevas, Ángeles

    2018-03-29

    Gastrointestinal symptoms (GIS) are common in patients with end-stage renal disease (ESRD) and are associated with nutritional risks resulting from low food intake. Little is known about the relationship between GIS and malnutrition in geriatric patients with ESRD. The main objective of this study was to determine the relationship between nutritional status and severity of GIS in geriatric patients on dialysis therapy. Clinically-stable geriatric patients (older than 60 years old) who were dialysis outpatients were included in this cross-sectional study. The severity of GIS was assessed using the Gastrointestinal Symptoms Questionnaire (GSQ, short version), with patients classified into three groups: mild, moderate, and severe. Nutritional status was evaluated with the Malnutrition Inflammation Score (MIS), anthropometric assessment, biochemical parameters, and bioelectrical impedance. Descriptive statistics were used and differences between groups were analyzed with ANOVA and Kruskal Wallis, with a p hemodialysis (HD) and 27 were on peritoneal dialysis (PD). No significant differences were found according to dialysis modality, presence of diabetes, or gender. Ninety percent of patients had at least one GIS. Poorer nutritional status (evaluated by MIS) was related to a higher severity of GIS. There were no significant differences with other nutritional parameters. Our study showed a high prevalence of GIS in geriatric patients. There were no differences in observed GIS values that were attributed to dialysis modality, gender, or presence of type 2 diabetes mellitus (DM2). Severe GIS values were associated with poorer nutritional status determined by MIS, however, there was no association with anthropometry, biochemical values, or bioimpedance vector analysis.

  9. Improvement of two-stage GM refrigerator performance using a hybrid regenerator

    International Nuclear Information System (INIS)

    Ke, G.; Makuuchi, H.; Hashimoto, T.; Onishi, A.; Li, R.; Satoh, T.; Kanazawa, Y.

    1994-01-01

    To improve the performance of two-stage GM refrigerators, a hybrid regenerator with magnetic materials of Er 3 Ni and ErNi 0.9 Co 0.1 was used in the 2nd stage regenerator because of its large heat exchange capacity. The largest refrigeration capacity achieved with the hybrid regenerator was 0.95W at helium liquefied temperature of 4.2K. This capacity is 15.9% greater than the 0.82W refrigerator with only Er 3 Ni as the 2nd regenerator material. Use of the hybrid regenerator not only increases the refrigeration capacity at 4.2K, but also allows the 4K GM refrigerator to be used with large 1st stage refrigeration capacity, thus making it more practical

  10. Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: A crosssectional study

    Directory of Open Access Journals (Sweden)

    Vanessa Fernanda Goes

    2014-04-01

    Full Text Available Alzheimer’s disease (AD is characterized by disorders that can impair the nutrition of the patient and lead to weight loss and nutritional deficits during the course of the disease. The aim of this study was to assess the nutritional status and food intake of Brazilian patients with Alzheimer’s disease at 3 different stages of the disease. The sample consisted of 30 subjects of both genders, mean age 77 years, with probable AD. Subjects were assessed by collecting anthropometric data, the Mini Nutritional Assessment (MNA, serum albumin content, Mini Mental State Examination and 24-hour records of food and drink. Although a steady decrease in average weight was observed as the disease progressed (CDR1: 70.8±15.9 kg; CDR2: 61.4±15.7 kg; CDR3: 56.1± 8.4 kg, the differences were not significant. MNA and serum albumin both fell during the progression of the disease (p = 0.042; p = 0.047, respectively and, at the severe stage, half the patients were found to be undernourished and the other half at risk of undernutrition. According to their body mass index, 23.3% of patients were overweight. The nutritional value of the food consumed was similar across the stages of AD. In conclusion, the majority of Brazilian patients with AD in this study exhibited cognitive decline and malnutrition. However, food intake was similar among the stages of the disease, thus having no direct association with the progression of AD.

  11. Current status of PET in breast cancer imaging, staging, and therapy.

    Science.gov (United States)

    Wahl, R L

    2001-07-01

    The exact roles of PET in the imaging management of patients with known or suspected breast cancer are still in evolution. For assessing primary lesions, it is sometimes possible with PET to detect cancers occult on standard methods. This could be useful in high-risk patient populations, but in dense breasts, background FDG uptake is often higher than in women with fatty breasts, making identification of lesions primary breast disease would seem better addressed by biopsy. With a positive predictive value of FDG PET for cancer over 96%, any FDG-avid breast lesion is highly suspicious and merits biopsy. Although PET in theory should be useful for depicting multifocal disease before surgery, the limitations in detecting small lesions in the breast limit the contribution of PET at present. It is most likely that PET will have a greater role in depicting primary breast lesions as dedicated PET imaging devices for the breast evolve. For axillary and internal mammary nodal staging, results with FDG PET are variable. Small nodal metastases setting is not known, nor is there consensus on how identifying internal mammary node metastases will change treatment. Based on the available data, for pT1 breast lesions, PET, if negative, is not an adequate replacement for sentinel node surgery or axillary dissection. Results from the multicenter trial will be of great interest. Clearly PET can stage metastatic disease well. Bone scans with 18F- are exquisitely sensitive for metastases, and FDG is also very good. However, FDG PET can miss some blastic metastases to bone so at present FDG is not capable of excluding the presence of bone metastases. PET seems very well suited to detecting recurrences in soft tissues and the brachial plexus region in particular. The utility of PET in planning the treatment of individual patients appears promising. Although results must be confirmed in larger studies, it appears safe to conclude that failure of a chemotherapy regimen to decrease FDG

  12. Global Performance Status Score: A New Tool to Assess Physical Performance in Kidney Transplant Patients.

    Science.gov (United States)

    Esposito, P; Furini, F; Gregorini, M; Pattonieri, E F; Corradetti, V; La Porta, E; Caramella, E; Calatroni, M; Petrucci, L; Klersy, C; Rampino, T

    Information on physical performance in renal transplantation is limited because of the shortage of specifically designed evaluation instruments. Therefore, we elaborated and validated the Global Performance Status (GloPerSta) score to provide a new and comprehensive tool, exploring the different components of physical performance in kidney transplant patients. We elaborated the GloPerSta score on the basis of the data obtained from a cross-sectional study, in which we evaluated the physical performance of a cohort of kidney transplant patients. The results of these analyses were weighted to describe the different contribution of any single test, via the generation of a structural equation model, resulting in the definition of the GloPerSta. Then, to internally validate this score, we studied its correlation with clinical parameters and quality of life (evaluated as KDQOL-SF, Kidney Disease Quality of Life-Short Form) in the same patient population. We enrolled 132 patients in whom the functional tests revealed a great heterogeneity. GloPerSta allowed the stratification of the patients in 3 different physical performance categories (low: score 0-11; medium: 12-22; high: 23-33). Internal validation showed that GloPerSta was directly and significantly correlated with the quality of life and allograft function, independent of the time from transplantation. The GloPerSta is a reliable tool to assess physical performance in a kidney transplant population. Its application might be of help in identifying patients needing intensive and personalized rehabilitation programs. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Development of a multi-stage cloud water collector. Part 1: Design and field performance evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Moore, K.F.; Sherman, D.E.; Reilly, J.; Collett, J.L. Jr. [Colarado State Univ., Fort Collins, CO (United States). Dept. of Atmospheric Science

    2002-07-01

    Cloud chemistry can vary as a function of drop size. In order to investigate variations in chemical composition across the drop size spectrum, a new multi-stage cloud water collector was developed. The Colorado State University 5-Stage cloud water collector (CSU 5-Stage) separates drops, based upon the principles of cascade inertial impaction, into five different fractions. Its design incorporates many features to facilitate its use in the field, and maintain both consistent performance between varying atmospheric conditions and the chemical and physical integrity of the collected sample. Limited field tests indicate the CSU 5-Stage works reasonably within field measurement uncertainty, and its results are comparable to those from other cloud collectors and consistent with additional concurrent measurements. Data obtained using the CSU 5-Stage provide additional insight into drop size-dependent chemistry in fogs/clouds. These insights should result in an improved understanding of both the impact of clouds on the fate of atmospheric species, and cloud microphysics and dynamics.

  14. Performance analysis of RDF gasification in a two stage fluidized bed-plasma process.

    Science.gov (United States)

    Materazzi, M; Lettieri, P; Taylor, R; Chapman, C

    2016-01-01

    The major technical problems faced by stand-alone fluidized bed gasifiers (FBG) for waste-to gas applications are intrinsically related to the composition and physical properties of waste materials, such as RDF. The high quantity of ash and volatile material in RDF can provide a decrease in thermal output, create high ash clinkering, and increase emission of tars and CO2, thus affecting the operability for clean syngas generation at industrial scale. By contrast, a two-stage process which separates primary gasification and selective tar and ash conversion would be inherently more forgiving and stable. This can be achieved with the use of a separate plasma converter, which has been successfully used in conjunction with conventional thermal treatment units, for the ability to 'polish' the producer gas by organic contaminants and collect the inorganic fraction in a molten (and inert) state. This research focused on the performance analysis of a two-stage fluid bed gasification-plasma process to transform solid waste into clean syngas. Thermodynamic assessment using the two-stage equilibrium method was carried out to determine optimum conditions for the gasification of RDF and to understand the limitations and influence of the second stage on the process performance (gas heating value, cold gas efficiency, carbon conversion efficiency), along with other parameters. Comparison with a different thermal refining stage, i.e. thermal cracking (via partial oxidation) was also performed. The analysis is supported by experimental data from a pilot plant. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. DAΦNE Control System status and performance

    International Nuclear Information System (INIS)

    Di Pirro, G.; Drago, A.; Mazzitelli, G.; Milardi, C.; Sannibale, F.; Stecchi, A.; Stella, A.

    1998-01-01

    The DAΦNE Control System allowed the step by step commissioning of the major subsystems as they were installed, proving to be modular and extensible. Recently the guidelines of the Control System evolution concerned the development of machine operational procedures and the integration of diagnostic tools. Particular attention has been reserved to the problem of saving and restoring element data sts as well as to the DAΦNE general data handling. A system overview including installation status, features, and operation results is presented

  16. Nutritional Status Predicts 10-Year Mortality in Patients with End-Stage Renal Disease on Hemodialysis

    Directory of Open Access Journals (Sweden)

    Shin Sook Kang

    2017-04-01

    Full Text Available Protein-energy wasting (PEW is associated with mortality in patients with end-stage renal disease (ESRD on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR, and malnutrition inflammation score (MIS, were measured at baseline. Fifty-three patients died during the study. Survivors had significantly higher nPCR (1.10 ± 0.24 g/kg/day vs. 1.01 ± 0.21 g/kg/day; p = 0.048, energy intake (26.7 ± 5.8 kcal/kg vs. 24.3 ± 4.2 kcal/kg; p = 0.009 and protein intake (0.91 ± 0.21 g/kg vs. 0.82 ± 0.24 g/kg; p = 0.020, and lower MIS (5.2 ± 2.3 vs. 6.1 ± 2.1, p = 0.039. In multivariable analysis, energy intake <25 kcal/kg (HR 1.860, 95% CI 1.018–3.399; p = 0.044 and MIS > 5 (HR 2.146, 95% CI 1.173–3.928; p = 0.013 were independent variables associated with all-cause mortality. These results suggest that higher MIS and lower energy intake are harmful to ESRD patients on maintenance hemodialysis. Optimal energy intake could reduce mortality in these patients.

  17. Nutritional Status Predicts 10-Year Mortality in Patients with End-Stage Renal Disease on Hemodialysis.

    Science.gov (United States)

    Kang, Shin Sook; Chang, Jai Won; Park, Yongsoon

    2017-04-18

    Protein-energy wasting (PEW) is associated with mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR), and malnutrition inflammation score (MIS), were measured at baseline. Fifty-three patients died during the study. Survivors had significantly higher nPCR (1.10 ± 0.24 g/kg/day vs. 1.01 ± 0.21 g/kg/day; p = 0.048), energy intake (26.7 ± 5.8 kcal/kg vs. 24.3 ± 4.2 kcal/kg; p = 0.009) and protein intake (0.91 ± 0.21 g/kg vs. 0.82 ± 0.24 g/kg; p = 0.020), and lower MIS (5.2 ± 2.3 vs. 6.1 ± 2.1, p = 0.039). In multivariable analysis, energy intake 5 (HR 2.146, 95% CI 1.173-3.928; p = 0.013) were independent variables associated with all-cause mortality. These results suggest that higher MIS and lower energy intake are harmful to ESRD patients on maintenance hemodialysis. Optimal energy intake could reduce mortality in these patients.

  18. 198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

    International Nuclear Information System (INIS)

    Ryu, Yoshiharu; Shibuya, Hitoshi; Hayashi, Keiji

    2013-01-01

    Brachytherapy using 198 Au grains is minimally invasive and the only curative treatment for early tongue cancer in patients of advanced age or poor performance status available in our institution. From March 1993 to February 2008, 198 Au grains were used to treat a group of 96 Stage I–II tongue cancer patients who could not undergo surgery or brachytherapy using 192 Ir pins because of an advanced age (≥75 years) or poor performance status (≥2). The patients were followed for 3.9 ± 3.3 years, and the cause-specific survival and local control rates were determined. Survival analyses were performed using the Kaplan-Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazard model. The results were compared with those for a group of 193 early tongue-cancer patients who underwent treatment using iridium pins. The 5-year cause-specific survival and local control rates of the 198 Au grains group were 71% and 68%, respectively, both of which were 16% lower than the corresponding rates for the 192 Ir pins group. Our study demonstrated that as the last curative treatment available, 198 Au grain implantation could be used to achieve moderate treatment results for early tongue cancer in patients of advanced age or poor performance status

  19. Multi-disciplinary design optimization and performance evaluation of a single stage transonic axial compressor

    International Nuclear Information System (INIS)

    Lee, Sae Il; Lee, Dong Ho; Kim, Kyu Hong; Park, Tae Choon; Lim, Byeung Jun; Kang, Young Seok

    2013-01-01

    The multidisciplinary design optimization method, which integrates aerodynamic performance and structural stability, was utilized in the development of a single-stage transonic axial compressor. An approximation model was created using artificial neural network for global optimization within given ranges of variables and several design constraints. The genetic algorithm was used for the exploration of the Pareto front to find the maximum objective function value. The final design was chosen after a second stage gradient-based optimization process to improve the accuracy of the optimization. To validate the design procedure, numerical simulations and compressor tests were carried out to evaluate the aerodynamic performance and safety factor of the optimized compressor. Comparison between numerical optimal results and experimental data are well matched. The optimum shape of the compressor blade is obtained and compared to the baseline design. The proposed optimization framework improves the aerodynamic efficiency and the safety factor.

  20. Performance of μ-RWELL detector vs resistivity of the resistive stage

    Science.gov (United States)

    Bencivenni, G.; De Oliveira, R.; Felici, G.; Gatta, M.; Morello, G.; Ochi, A.; Lener, M. Poli; Tskhadadze, E.

    2018-04-01

    The μ-RWELL is a compact spark-protected single amplification stage Micro-Pattern-Gaseous-Detector (MPGD). The detector amplification stage is realized with a polyimide structure, micro-patterned with a dense matrix of blind-holes, integrated into the readout structure. The anode is formed by a thin Diamond Like Carbon (DLC) resistive layer separated by an insulating glue layer from the readout strips. The introduction of the resistive layer strongly suppressing the transition from streamer to spark gives the possibility to achieve large gains (> 104), without significantly affecting the capability to be efficiently operated in high particle fluxes. In this work we present the results of a systematic study of the μ-RWELL performance as a function of the DLC resistivity. The tests have been performed either with collimated 5.9 keV X-rays or with pion and muon beams at the SPS Secondary Beamline H4 and H8 at CERN.

  1. One-Stage and Two-Stage Schemes of High Performance Synchronous PWM with Smooth Pulses-Ratio Changing

    DEFF Research Database (Denmark)

    Oleschuk, V.; Blaabjerg, Frede

    2002-01-01

    This paper presents detailed description of one-stage and two-stage schemes of a novel method of synchronous, pulsewidth modulation (PWM) for voltage source inverters for ac drive application. The proposed control functions provide accurate realization of different versions of voltage space vector...... modulation with synchronization of the voltage waveform of the inverter and with smooth pulse-ratio changing. Voltage spectra do not contain even harmonic and sub-harmonics (combined harmonics) during the whole control range including the zone of overmodulation. Examples of determination of the basic control...

  2. [Nephroprotective role of early correction of impaired nutritional status in patients with chronic disease of the kidneys at a predialysis stage].

    Science.gov (United States)

    Milovanov, Iu S; Kozlovskaia, L V; Milovanova, L Iu

    2008-01-01

    To assess the rate and clinical significance of impaired nutritional status and impact of low-protein diet on inhibition of renal insufficiency in patients of stage III-IV chronic disease of the kidneys (CDK). A total of 200 patients with CDK stage III-IV were randomized into three groups: group 1 consisted of 123 patients with chronic glomerulonephritis (73 with stage III and 50 with stage 1V), group 2--45 patients with systemic diseases (30 with stage III and 15 with stage IV), group 3 (a comparison group)--32 patients with CGN (17 with stage 111 and 15 with stage IV). Patients of groups 1 and 2 received low-protein diet (0.6 g protein kg/day) balanced by either high-calorie mix containing protein SUPRO 760 or ketosteril for 24-48 months. The nutritional status was studied by anthropometric data, absolute number of lymphocytes, levels of blood albumin and transferring, intake of protein, food calorie value according to 3-day diaries. Among 200 patients impaired nutritional status was detected in 22 (11.0%) patients. More than half of them had glomerulonephritis in systemic diseases (SLE, systemic vasculitis). Only in patients with systemic diseases nutritional disorders manifested at stage III. These disorders grew with progression of renal insufficiency and were detected primarily in patients with stage IV CDK. Patients with CGN on low-protein diet for a year and longer demonstrated slowing of the fall of the glomerular filtration rate (GFR). Early (predialysis) use of low-protein diet balanced by addition of amino- and keto-acids and high-energy nutritional mixes has a positive influence on nutritional status of patients with chronic renal insufficiency and can inhibit GFR lowering.

  3. Comparison of the performance of two indices of trophic status for depicting the status of Pulicat lagoon ecosystem.

    Science.gov (United States)

    Santhanam, Harini; Raj, S Amal; Thanasekaran, K

    2011-10-01

    In the recent years, several indices of trophic status of coastal ecosytems are being used worldwide. However, not all of them can be applied successfully to depict the true trophic status of shallow coastal ecosystems due to their inherent complexities in nutrient circulation and interactions between biotic organisms. The most widely used index is Carlson's Trophic State Index (TSI), while more recently, several environmental indices have been constructed using soft computing techniques such as fuzzy logic. In the present investigation, a comparison of the performances of a conventional trophic state index and a newly developed fuzzy-based trophic state index has been presented in detail. The aim of the work was to highlight the advantages of the newer technique over the existing techniques in light of the inherent variability of both data as well as the sampling procedures undertaken for studying a coastal lagoon ecosystem called Pulicat lagoon in the southeast coast of India. The results of the study have shown that while there are discrepancies in depicting the trophic status of the lagoon using Carlson's index, the newer logic-based index predicted the trophic status accurately which was verified by field assessments. Thus the successful application of a more reliable index to estimate trophic status has been presented.

  4. Is Playing in the Pit Really the Pits?: Pain, Strength, Music Performance Anxiety, and Workplace Satisfaction in Professional Musicians in Stage, Pit, and Combined Stage/Pit Orchestras.

    Science.gov (United States)

    Kenny, Dianna T; Driscoll, Tim; Ackermann, Bronwen J

    2016-03-01

    Typically, Australian orchestral musicians perform on stage, in an orchestra pit, or in a combination of both workplaces. This study explored a range of physical and mental health indicators in musicians who played in these different orchestra types to ascertain whether orchestra environment was a risk factor affecting musician wellbeing. Participants comprised 380 full-time orchestral musicians from the eight major state orchestras in Australia comprised of two dedicated pit orchestras, three stage-only symphonic orchestras, and three mixed stage/pit orchestras. Participants completed a physical assessment and a range of self-report measures assessing performance-related musculoskeletal disorders (PRMD), physical characteristics including strength and perceived exertion, and psychological health, including music performance anxiety (MPA), workplace satisfaction, and bullying. Physical characteristics and performance-related musculoskeletal profiles were similar for most factors on the detailed survey completed by orchestra members. The exceptions were that pit musicians demonstrated greater shoulder and elbow strength, while mixed-workload orchestra musicians had greater flexibility Significantly more exertion was reported by pit musicians when rehearsing and performing. Stage/pit musicians reported less physical exertion when performing in the pit compared with performing on stage. Severity of MPA was significantly greater in pit musicians than mixed orchestra musicians. Pit musicians also reported more frequent bullying and lower job satisfaction compared with stage musicians. There were few differences in the objective physical measures between musicians in the different orchestra types. However, pit musicians appear more psychologically vulnerable and less satisfied with their work than musicians from the other two orchestra types. The physical and psychological characteristics of musicians who perform in different orchestra types have not been adequately

  5. Diagnosing and staging of cystic echinococcosis: how do CT and MRI perform in comparison to ultrasound?

    Directory of Open Access Journals (Sweden)

    Marija Stojkovic

    Full Text Available BACKGROUND: Imaging plays the key role in diagnosing and staging of CE. The description of CE-specific imaging features and the WHO CE cyst classification is based on ultrasound. The reproducibility of the ultrasound-defined features of CE cysts is variable in MR- and CT-imaging. This is of particular importance for cysts that are not accessible by US and because of the increasing availability and overuse of CT and MR imaging. METHODOLOGY/PRINCIPAL FINDINGS: Retrospective analysis of patients with abdominal CE cysts of an interdisciplinary CE clinic who had CT and/or MRI scans performed additionally to US imaging. All images were read and interpreted by the same senior radiologist experienced in the diagnosis of CE. US, CT and MR images were staged according to the WHO classification criteria. The agreement beyond chance was quantified by kappa coefficients (κ. 107 patients with 187 CE cysts met the inclusion criteria. All cysts were assessed by US, 138 by CT, and 125 by MRI. The level of agreement beyond chance of the individual CE stages 1-4 was clearly lower for CT, with κ ranging from 0.62 to 0.72, compared to MRI with values of κ between 0.83 and 1.0. For CE5 cysts CT (κ = 0.95 performed better than MRI (κ = 0.65. CONCLUSIONS: Ultrasound remains the corner stone of diagnosis, staging and follow up of CE cysts. MRI reproduces the ultrasound-defined features of CE better than CT. If US cannot be performed due to cyst location or patient-specific reasons MRI with heavily T2-weighted series is preferable to CT.

  6. Cognitive Performance, Mood, and Neurological Status at High Terrestrial Elevation

    National Research Council Canada - National Science Library

    Banderet, Louis

    2002-01-01

    Cognitive and psychomotor performance and mood states, including many critical behavioral functions such as sleep, memory, reasoning, and vigilance, are significantly impaired by ascent to HTE higher than 3,000 m...

  7. MSFC Turbine Performance Optimization (TPO) Technology Verification Status

    Science.gov (United States)

    Griffin, Lisa W.; Dorney, Daniel J.; Snellgrove, Lauren M.; Zoladz, Thomas F.; Stroud, Richard T.; Turner, James E. (Technical Monitor)

    2002-01-01

    Capability to optimize for turbine performance and accurately predict unsteady loads will allow for increased reliability, Isp, and thrust-to-weight. The development of a fast, accurate, validated aerodynamic design, analysis, and optimization system is required.

  8. NASA Soil Moisture Active Passive Mission Status and Science Performance

    Science.gov (United States)

    Yueh, Simon H.; Entekhabi, Dara; O'Neill, Peggy; Njoku, Eni; Entin, Jared K.

    2016-01-01

    The Soil Moisture Active Passive (SMAP) observatory was launched January 31, 2015, and its L-band radiometer and radar instruments became operational since mid-April 2015. The SMAP radiometer has been operating flawlessly, but the radar transmitter ceased operation on July 7. This paper provides a status summary of the calibration and validation of the SMAP instruments and the quality assessment of its soil moisture and freeze/thaw products. Since the loss of the radar in July, the SMAP project has been conducting two parallel activities to enhance the resolution of soil moisture products. One of them explores the Backus Gilbert optimum interpolation and de-convolution techniques based on the oversampling characteristics of the SMAP radiometer. The other investigates the disaggregation of the SMAP radiometer data using the European Space Agency's Sentinel-1 C-band synthetic radar data to obtain soil moisture products at about 1 to 3 kilometers resolution. In addition, SMAP's L-band data have found many new applications, including vegetation opacity, ocean surface salinity and hurricane ocean surface wind mapping. Highlights of these new applications will be provided.

  9. Performance Characterization of an xy-Stage Applied to Micrometric Laser Direct Writing Lithography

    Directory of Open Access Journals (Sweden)

    Juan Jaramillo

    2017-01-01

    Full Text Available This article concerns the characterization of the stability and performance of a motorized stage used in laser direct writing lithography. The system was built from commercial components and commanded by G-code. Measurements use a pseudo-periodic-pattern (PPP observed by a camera and image processing is based on Fourier transform and phase measurement methods. The results report that the built system has a stability against vibrations determined by peak-valley deviations of 65 nm and 26 nm in the x and y directions, respectively, with a standard deviation of 10 nm in both directions. When the xy-stage is in movement, it works with a resolution of 0.36 μm, which is an acceptable value for most of research and development (R and D microtechnology developments in which the typical feature size used is in the micrometer range.

  10. Performance Characterization of an xy-Stage Applied to Micrometric Laser Direct Writing Lithography.

    Science.gov (United States)

    Jaramillo, Juan; Zarzycki, Artur; Galeano, July; Sandoz, Patrick

    2017-01-31

    This article concerns the characterization of the stability and performance of a motorized stage used in laser direct writing lithography. The system was built from commercial components and commanded by G-code. Measurements use a pseudo-periodic-pattern (PPP) observed by a camera and image processing is based on Fourier transform and phase measurement methods. The results report that the built system has a stability against vibrations determined by peak-valley deviations of 65 nm and 26 nm in the x and y directions, respectively, with a standard deviation of 10 nm in both directions. When the xy-stage is in movement, it works with a resolution of 0.36 μm, which is an acceptable value for most of research and development (R and D) microtechnology developments in which the typical feature size used is in the micrometer range.

  11. The physical performance test predicts aerobic capacity sufficient for independence in early-stage Alzheimer disease.

    Science.gov (United States)

    Vidoni, Eric D; Billinger, Sandra A; Lee, Charesa; Hamilton, Jenna; Burns, Jeffrey M

    2012-01-01

    Early identification of physical impairment related to Alzheimer disease (AD) is increasingly identified as an important aspect of diagnosis and care. Clinically accessible tools for evaluating physical capacity and impairment in AD have been developed but require further characterization for their effective use. To assess the utility of the Physical Performance Test (PPT) for identifying functionally limiting aerobic capacity in older adults with AD and without dementia. Secondary analysis of a dataset of community dwelling older adults, 70 without dementia and 60 with early-stage AD. Participants were administered the PPT and performed a graded maximal exercise test. The clinical utility of 2 versions of the PPT was described by determining sensitivity and specificity to functionally limiting aerobic capacity. The 9-item PPT is predictive of diminished aerobic capacity in older adults with AD. A score of 28 or less indicates likelihood of functionally limiting aerobic capacity that would limit independent function with 67% sensitivity and 67% specificity. The 4-item mini-PPT demonstrates improved capability for identifying impaired functional aerobic capacity with 85% sensitivity and 62% specificity. The PPT was not useful for identifying impaired functional aerobic capacity in older adults without dementia. The PPT, which incorporates basic and instrumental activities of daily living as test items, and the mini-PPT which focuses on basic activities of daily living and simple physical functions, are both clinically useful tool for the evaluation for individuals in the earliest stages of AD and both provide important information about functional performance. The mini-PPT additionally inform the clinician as to whether or not individual with early-stage AD is likely to have insufficient aerobic capacity to perform instrumental daily functions.

  12. Growth performance and immunity status of starter broiler birds ...

    African Journals Online (AJOL)

    This study was conducted to investigate the effects of feeding diets containing Neem Leaf Meal (NLM), Garlic Meal (GM) and their combinations (NLM + GM) on growth performance and serum parameters of starter broiler birds. A total of 180 day-old Cobb broiler chickens were divided into twelve groups of fifteen chicks with ...

  13. Effects of ownership and financial status on corporate environmental performance

    Czech Academy of Sciences Publication Activity Database

    Earnhart, D.; Lízal, Lubomír

    2002-01-01

    Roč. 13, č. 4-5 (2002), s. 67-68 ISSN 1020-5470 Institutional research plan: CEZ:AV0Z7085904 Keywords : ownership structures * privatization * financial performance Subject RIV: AH - Economics http://go.worldbank.org/JL12RVXEW0

  14. Growth performance, immune status and organ morphometry in ...

    African Journals Online (AJOL)

    The present research aimed to investigate the effects of Bacillus subtilis (B. subtilis) on performance, immune system, gut, and lymphoid organs' microarchitecture in broilers. A total of 120 day-old broiler chicks were randomly distributed into four groups. The birds were fed a corn-soy-based basal diet (BD) (control) or the ...

  15. Socioeconomic Status and Performance in the US Army and US Marine Corps

    National Research Council Canada - National Science Library

    Booth, Stefan

    1998-01-01

    The purpose or this study was to examine socioeconomic status (SES) of recruits in the Army and Marine Corps and to analyze the relationship between a recruit's SES background and his or her performance in the military over time...

  16. Status of High Performance PV: Polycrystalline Thin-Film Tandems

    Energy Technology Data Exchange (ETDEWEB)

    Symko-Davies, M.

    2005-02-01

    The High-Performance Photovoltaic (HiPerf PV) Project was initiated by the U.S. Department of Energy to substantially increase the viability of photovoltaics (PV) for cost-competitive applications so that PV can contribute significantly to our energy supply and our environment. The HiPerf PV Project aims at exploring the ultimate performance limits of existing PV technologies, approximately doubling their sunlight-to-electricity conversion efficiencies during its course. This work includes bringing thin-film cells and modules toward 25% and 20% efficiencies, respectively, and developing multijunction concentrator cells and modules able to convert more than one-third of the sun's energy to electricity (i.e., 33% efficiency). This paper will address recent accomplishments of the NREL in-house research effort involving polycrystalline thin-film tandems, as well as the research efforts under way in the subcontracted area.

  17. Methodology of the Integrated Analysis of Company's Financial Status and Its Performance Results

    OpenAIRE

    Mackevičius, Jonas; Valkauskas, Romualdas

    2010-01-01

    Information about company's financial status and its performance results is very important for the objective evaluation of company's position in the market and competitive possibilities in the future. Such information is provided in the financial statement. It is important to apply and investigate this information properly. The methodology of company's financial status and performance results integrated analysis is recommended in this article. This methodology consists of these three elements...

  18. The relationship between school absence, academic performance, and asthma status.

    Science.gov (United States)

    Moonie, Sheniz; Sterling, David A; Figgs, Larry W; Castro, Mario

    2008-03-01

    Children with asthma experience more absenteeism from school compared with their nonasthma peers. Excessive absenteeism is related to lower student grades, psychological, social, and educational adjustment. Less is known about the relationship between the presence of asthma and the academic achievement in school-aged children. Since students with asthma miss more days from school, this may negatively impact their academic achievement. The goal of this study was to investigate the relationships between absenteeism, presence of asthma, and asthma severity level with standardized test level performance in a predominantly African American urban school district. A cross-sectional analysis was conducted of 3812 students (aged 8-17 years) who took the Missouri Assessment Program (MAP) standardized test during the 2002-2003 academic year. After adjustment for covariates, a significant inverse relationship was found between absenteeism and test level performance on the MAP standardized test in all children (F = 203.9, p achievement between those with and without asthma (p = .12). Though not statistically different, those with persistent asthma showed a modestly increased likelihood of scoring below Nearing Proficient compared with those with mild intermittent asthma (adjusted odds ratio = 1.93, 95% confidence intervals = 0.93-4.01, p = .08). A negative impact of absenteeism on standardized test level achievement was demonstrated in children from an urban African American school district. Children with asthma perform the same academically as their nonasthma peers. However, those with persistent asthma show a trend of performing worse on MAP standardized test scores and have more absence days compared with other students. More research is warranted on the effects of persistent asthma on academic achievement.

  19. Present Status and Extensions of the Monte Carlo Performance Benchmark

    Science.gov (United States)

    Hoogenboom, J. Eduard; Petrovic, Bojan; Martin, William R.

    2014-06-01

    The NEA Monte Carlo Performance benchmark started in 2011 aiming to monitor over the years the abilities to perform a full-size Monte Carlo reactor core calculation with a detailed power production for each fuel pin with axial distribution. This paper gives an overview of the contributed results thus far. It shows that reaching a statistical accuracy of 1 % for most of the small fuel zones requires about 100 billion neutron histories. The efficiency of parallel execution of Monte Carlo codes on a large number of processor cores shows clear limitations for computer clusters with common type computer nodes. However, using true supercomputers the speedup of parallel calculations is increasing up to large numbers of processor cores. More experience is needed from calculations on true supercomputers using large numbers of processors in order to predict if the requested calculations can be done in a short time. As the specifications of the reactor geometry for this benchmark test are well suited for further investigations of full-core Monte Carlo calculations and a need is felt for testing other issues than its computational performance, proposals are presented for extending the benchmark to a suite of benchmark problems for evaluating fission source convergence for a system with a high dominance ratio, for coupling with thermal-hydraulics calculations to evaluate the use of different temperatures and coolant densities and to study the correctness and effectiveness of burnup calculations. Moreover, other contemporary proposals for a full-core calculation with realistic geometry and material composition will be discussed.

  20. The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.

    Directory of Open Access Journals (Sweden)

    Juliana Casimiro de Almeida

    Full Text Available Stunting, anemia and inflammation are frequently observed in children with end-stage renal disease (ESRD.To assess anthropometric, hematological and inflammatory data and to study their potential interrelationship in Guatemalan juveniles undergoing hemodialysis (HD and peritoneal dialysis (PD.54 juveniles 7-20 years of age were recruited in FUNDANIER, Guatemala City: 27 on HD and 27 PD. Hemoglobin, serum iron, transferrin, serum transferrin receptor (sTfR, serum ferritin, transferrin saturation and iron-binding capacity, white blood cell count (WBC, erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, as well as IL-6, IL-1 and TNF-α, weight and height were determined by standard methods. Hepcidin-25 (Hep-25 was assessed by weak cation exchange time-of-flight mass-spectrometry.92% and 55% of HD and PD children, respectively, were stunted and 95% and 85% were anemic. Among iron status biomarkers, serum ferritin was massively increased and significantly higher in the HD group compared to the PD group. Hep-25 was also greatly elevated in both groups. 41% of HD patients showed increments in three or more inflammatory biomarkers, while it was 2 or less in all PD subjects.The degree of stunting, the prevalence and severity of anemia in Guatemalan juvenile ESRD far exceed the national statistics for this low-income Central American country. Ferritin and Hep-25 concentrations were elevated, with the latter to an extraordinary magnitude. Additional biomarkers of inflammation not directly related to iron status were elevated as well. The role of both disease- and environment-related factors in combination best explains the magnitude of the biomarker abnormalities.

  1. Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else?

    Science.gov (United States)

    Nyrop, Kirsten A; Deal, Allison M; Lee, Jordan T; Muss, Hyman B; Choi, Seul Ki; Wheless, Amy; Carey, Lisa A; Shachar, Shlomit S

    2018-01-01

    This study investigates weight trajectories in pre- versus postmenopausal breast cancer (BC) survivors diagnosed with hormone receptor-positive tumors, with a specific focus on discerning menopausal status and type of endocrine treatment (ET) as risk factors for weight gain during ET. We conducted a retrospective review of electronic medical records. Descriptive statistics and Chi-squared and t tests were used to compare pre- and postmenopausal women. Chi-squared tests and ANOVA were used for within-group associations between patient characteristics and weight trajectories. Log-binomial regression models were used to estimate relative risk for weight gain. The final sample was 32% premenopausal (n = 140) and 68% postmenopausal (n = 298). Relative risk (RR) for weight gain during ET was highest in women who were premenopausal (RR = 1.29, 1.03-1.52) and had Stage 3 BC (RR = 2.12, 1.59-2.82), mastectomy (RR = 1.49, 1.19-1.88), axillary node dissection (RR = 1.39, 1.11-1.73), and chemotherapy (RR = 1.80, 1.37-2.36). For each kg of weight gained between BC diagnosis and start of ET, and for each additional year of age, RR of gaining weight during ET decreased (RR = 0.98, 0.97-0.99, and RR = 0.99, 0.98-0.99, respectively). Menopausal status and type of ET were not significant predictors of weight gain. In multivariable analysis, only weight loss between BC diagnosis and start of ET was significant. The association of weight loss prior to ET and subsequent substantial weight gain during ET warrants further investigation.

  2. Performance evaluation of a piezoactuator-based single-stage valve system subjected to high temperature

    International Nuclear Information System (INIS)

    Jeon, Juncheol; Han, Chulhee; Ung Chung, Jye; Choi, Seung-Bok

    2015-01-01

    In this paper, a novel single-stage valve system activated by a piezostack actuator is proposed and experimentally evaluated at both room temperature (20 °C) and high temperature (100 °C) conditions. A hinge-lever displacement amplifier is adopted in the valve system to magnify the displacement generated from the piezostack actuator. After explaining the operating principle of the proposed piezostack-driven single-stage valve system, the geometric dimensions and mechanical properties of the valve components are discussed in details. An experimental apparatus is then manufactured to evaluate the performances of the valve system such as flow rate. The experimental apparatus consists of a heat chamber, which can regulate the temperature of the valve system and oil, pneumatic-hydraulic cylinders, a hydraulic circuit, a pneumatic circuit, electronic devices, an interface card, and a high voltage amplifier. The pneumatic-hydraulic cylinder transforms the pneumatic pressure into hydraulic pressure. The performances of the valve system regarding spool response, pressure drop, and flow rate are evaluated and presented. In addition, the performance of the valve system under high temperature condition is compared with that under room temperature condition. The experimental results are plotted in both frequency and time domains. (paper)

  3. Performance assessment of two-stage anaerobic digestion of kitchen wastes.

    Science.gov (United States)

    Bo, Zhang; Pin-Jing, He

    2014-01-01

    This study is aimed at investigating the performance of the two-phase anaerobic digestion of kitchen wastes in a lab-scale setup. The semi-continuous experiment showed that the two-phase anaerobic digestion of kitchen wastes had a bioconversion rate of 83%, biogas yield of 338 mL x (g chemical oxygen demand (COD))(-1) and total solid conversion of 63% when the entire two-phase anaerobic digestion process was subjected to an organic loading rate (OLR) of 10.7 g x (L d)(-1). In the hydrolysis-acidogenesis process, the efficiency of solubilization decreased from 72.6% to 41.1%, and the acidogenesis efficiency decreased from 31.8% to 17.8% with an increase in the COD loading rate. On the other hand, the performance of the subsequent methanogenic process was not susceptible to the increase in the feeding COD loading rate in the hydrolysis-acidogenesis stage. Lactic acid was one of the main fermentation products, accounting for over 40% of the total soluble COD in the fermentation liquid. The batch experiments indicated that the lactic acid was the earliest predominant fermentation product, and distributions of fermentation products were pH dependent. Results showed that increasing the feeding OLR of kitchen wastes made the two-stage anaerobic digestion process more effective. Moreover, there was a potential improvement in the performance of anaerobic digestion of kitchen wastes with a corresponding improvement in the hydrolysis process.

  4. Performance characteristics of an excimer laser (XeCl) with single-stage magnetic pulse compression

    Science.gov (United States)

    Varshnay, N. K.; Singh, A.; Benerji, N. S.

    2017-02-01

    Performance characteristics of an excimer laser (XeCl) with single-stage magnetic pulse compression suitable for material processing applications are presented here. The laser incorporates in-built compact gas circulation and gas cooling to ensure fresh gas mixture between the electrodes for repetitive operation. A magnetically coupled tangential blower is used for gas circulation inside the laser chamber for repetitive operation. The exciter consists of C-C energy transfer circuit and thyratron is used as a high-voltage main switch with single-stage magnetic pulse compression (MPC) between thyratron and the laser electrodes. Low inductance of the laser head and uniform and intense pre-ionization are the main features of the electric circuit used in the laser. A 250 ns rise time voltage pulse was compressed to 100 ns duration with a single-stage magnetic pulse compressor using Ni-Zn ferrite cores. The laser can generate about 150 mJ at ˜100 Hz rep-rate reliably from a discharge volume of 100 cm 3. 2D spatial laser beam profile generated is presented here. The profile shows that the laser beam is completely filled with flat-top which is suitable for material processing applications. The SEM image of the microhole generated on copper target is presented here.

  5. Landsat-8: Status and on-orbit performance

    Science.gov (United States)

    Markham, Brian L; Barsi, Julia A.; Morfitt, Ron; Choate, Michael J.; Montanaro, Matthew; Arvidson, Terry; Irons, James R.

    2015-01-01

    Landsat 8 and its two Earth imaging sensors, the Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS) have been operating on-orbit for 2 ½ years. Landsat 8 has been acquiring substantially more images than initially planned, typically around 700 scenes per day versus a 400 scenes per day requirement, acquiring nearly all land scenes. Both the TIRS and OLI instruments are exceeding their SNR requirements by at least a factor of 2 and are very stable, degrading by at most 1% in responsivity over the mission to date. Both instruments have 100% operable detectors covering their cross track field of view using the redundant detectors as necessary. The geometric performance is excellent, meeting or exceeding all performance requirements. One anomaly occurred with the TIRS Scene Select Mirror (SSM) encoder that affected its operation, though by switching to the side B electronics, this was fully recovered. The one challenge is with the TIRS stray light, which affects the flat fielding and absolute calibration of the TIRS data. The error introduced is smaller in TIRS band 10. Band 11 should not currently be used in science applications.

  6. High performance 40-stage and 15-stage quantum cascade lasers based on two-material active region composition

    Science.gov (United States)

    Figueiredo, P.; Suttinger, M.; Go, R.; Todi, A.; Shu, Hong; Tsvid, E.; Patel, C. Kumar N.; Lyakh, A.

    2017-05-01

    5.6μm quantum cascade lasers based on Al0.78In0.22As/In0.69Ga0.31As active region composition with measured pulsed room temperature wall plug efficiency of 28.3% are reported. Injection efficiency for the upper laser level of 75% was measured by testing devices with variable cavity length. Threshold current density of 1.7kA/cm2 and slope efficiency of 4.9W/A were measured for uncoated 3.15mm x 9µm lasers. Threshold current density and slope efficiency dependence on temperature in the range from 288K to 348K can be described by characteristic temperatures T0 140K and T1 710K, respectively. Pulsed slope efficiency, threshold current density, and wallplug efficiency for a 2.1mm x 10.4µm 15-stage device with the same design and a high reflection-coated back facet were measured to be 1.45W/A, 3.1kA/cm2 , and 18%, respectively. Continuous wave values for the same parameters were measured to be 1.42W/A, 3.7kA/cm2 , and 12%. Continuous wave optical power levels exceeding 0.5W per millimeter of cavity length was demonstrated. When combined with the 40-stage device data, the inverse slope efficiency dependence on cavity length for 15-stage data allowed for separate evaluation of the losses originating from the active region and from the cladding layers of the laser structure. Specifically, the active region losses for the studied design were found to be 0.77cm-1, while cladding region losses - 0.33cm-1. The data demonstrate that active region losses in mid wave infrared quantum cascade lasers largely define total waveguide losses and that their reduction should be one of the main priorities in the quantum cascade laser design.

  7. Coping style and performance status in a group of oncological inpatients

    Directory of Open Access Journals (Sweden)

    Cecilia Chau Pérez-Aranibar

    2002-06-01

    Full Text Available The associations between coping styles, measured by COPE Test, dispositional version (Carver,Scheier and Weintraub, 1989, and Health Status inferred through a performance status, measured by Karnofsky's Index of Behavioral Performance are examined. The study focuses upon 28 oncological in patients. Positive moderate Pearson's correlations were found between these two variables in this correlational-descriptive study. These were interpreted in the following sense: the larger use of the style, the less health status among the scales suppression of competent activities, procrastination of coping, instrumental social support, focusing and releasing of emotions and behavioral disengagement. The active coping scale presented a negative correlationwith regard to Performance Status as a health measure.

  8. GPM Microwave Imager Design, Predicted Performance and Status

    Science.gov (United States)

    Krimchansky, Sergey; Newell, David

    2010-01-01

    The Global Precipitation Measurement (GPM) Microwave Imager (GMI) Instrument is being developed by Ball Aerospace and Technology Corporation (BATC) for the GPM program at NASA Goddard. The Global Precipitation Measurement (GPM) mission is an international effort managed by the National Aeronautics and Space Administration (t.JASA) to improve climate, weather, and hydro-meteorological predictions through more accurate and more frequent precipitation measurements. The GPM Microwave Imager (GMI) will be used to make calibrated, radiometric measurements from space at multiple microwave frequencies and polarizations. GMI will be placed on the GPM Core Spacecraft together with the Dual-frequency Precipitation Radar (DPR). The DPR is two-frequency precipitation measurement radar, which will operate in the Ku-band and Ka-band of the microwave spectrum. The Core Spacecraft will make radiometric and radar measurements of clouds and precipitation and will be the central element of GPM's space segment. The data products from GPM will provide information concerning global precipitation on a frequent, near-global basis to meteorologists and scientists making weather forecasts and performing research on the global energy and water cycle, precipitation, hydrology, and related disciplines. In addition, radiometric measurements from GMI and radar measurements from the DPR will be used together to develop a retrieval transfer standard for the purpose of calibrating precipitation retrieval algorithms. This calibration standard will establish a reference against which other retrieval algorithms using only microwave radiometers (and without the benefit of the DPR) on other satellites in the GPM constellation will be compared.

  9. Status of Terra MODIS Operation, Calibration, and Performance

    Science.gov (United States)

    Xiong, X.; Wenny, B.; Wu, A.; Angal, A.; Geng, X.; Chen, H.; Dodd, J.; Link, D.; Madhavan, S.; Chen, N.; hide

    2014-01-01

    Since launch in December 1999, Terra MODIS has successfully operated for nearly 15 years, making continuous observations. Data products derived from MODIS observations have significantly contributed to a wide range of studies of key geophysical parameters of the earth's eco-system of land, ocean, and atmosphere, and their changes over time. The quality of MODIS data products relies on the dedicated effort to monitor and sustain instrument health and operation, to calibrate and update sensor parameters and properties, and to improve calibration algorithms. MODIS observations are made in 36 spectral bands, covering wavelengths from visible to long-wave infrared. The reflective solar bands (1-19 and 26) are primarily calibrated by a solar diffuser (SD) panel and regularly scheduled lunar observations. The thermal emissive bands (20-25 and 27- 36) calibration is referenced to an on-board blackbody (BB) source. On-orbit changes in the sensor spectral and spatial characteristics are monitored by a spectroradiometric calibration assembly (SRCA). This paper provides an overview of Terra MODIS on-orbit operation and calibration activities and implementation strategies. It presents and summarizes sensor on-orbit performance using nearly 15 years of data from its telemetry, on-board calibrators, and lunar observations. Also discussed in this paper are changes in sensor characteristics, corrections applied to maintain MODIS level 1B (L1B) data quality, and efforts for future improvements.

  10. Operational studies and expected performance of superconducting quadrupole magnets in the first stages of secondary beams

    International Nuclear Information System (INIS)

    Garbincius, P.H.; Mazur, P.O.; Stanek, R.P.

    1983-08-01

    A low current, large bore, epoxy impregnated superconducting quadrupole magnet was constructed at Argonne National Laboratory as a possible prototype for secondary beam use. The quadrupole magnet was placed in the Fermilab P-West High Intensity Area beam for beam quenching tests. Tests were performed by targetting a primary proton beam directly onto the quadrupole coil and by using the quadrupole in its anticipated role as part of the first stage flux collection triplet for a zero degree anti-proton secondary beam formed from the decays of neutral Lambda particles. Comparing the results with similar tests performed using forced flow Energy Saver dipoles shows that the epoxy impregnated quadrupoles have a much greater sensitivity to beam induced quenching at a similar fraction of the conductor short sample limit. Using the CASIM program, calculations indicate that such eopxy impregnated coils would not be viable as first stage flux collection elements without appreciable collimation and subsequent loss of secondary beam acceptance. Quadrupoles based on Energy Saver technology appear capable of tolerating acceptable primary beam intensities. The momentum dispersing bends will require even larger aperture superconducting dipoles or neutral beam dump within the bend string

  11. The stage performance of Peer Gynt in Mysore: is 'global Ibsen' against globalization?

    Directory of Open Access Journals (Sweden)

    Sabiha Huq

    2015-02-01

    Full Text Available This article discusses an adaptation of Peer Gynt in the Kannada language, which was staged in the state of Karnataka, India in 1995. The director of the play asserted his concern of Western notion of interculturalism that is inevitably affected by the process of economic globalization, and according to him India has a different situation as there is ‘tremendous resistance’ to the homogenizing, commoditizing, and anti-democratic tendencies of globalization. Popular terms like ‘technology transfers’, ‘free trade’, ‘democracy’ etc., that are connected with globalization are criticized in the production and it is strongly rooted in serious issues like communal conflict and economic exploitation in contemporary India, providing a notion that globalization is a red herring to divert people from local realities. The analysis of the performance text and the images from the stage performance show how the creative forces behind this production were deeply preoccupied with the notion of the global vs. the national.

  12. Aerobic Exercise Sustains Performance of Instrumental Activities of Daily Living in Early-Stage Alzheimer Disease.

    Science.gov (United States)

    Vidoni, Eric D; Perales, Jaime; Alshehri, Mohammed; Giles, Abdul-Mannaan; Siengsukon, Catherine F; Burns, Jeffrey M

    2017-12-28

    Individuals with Alzheimer disease (AD) experience progressive loss of independence-performing activities of daily living. Identifying interventions to support independence and reduce the economic and psychosocial burden of caregiving for individuals with AD is imperative. The purpose of this analysis was to examine functional disability and caregiver time in individuals with early-stage AD. This was a secondary analysis of a randomized controlled trial of 26 weeks of aerobic exercise (AEx) versus stretching and toning (ST). We measured functional dependence using the Disability Assessment for Dementia, informal caregiver time required using the Resources Utilization in Dementia Lite, and cognition using a standard cognitive battery. We saw a stable function in the AEx group compared with a significant decline in the ST group (4%; F = 4.2, P = .04). This was especially evident in more complex, instrumental activities of daily living, with individuals in the AEx group increasing 1% compared with an 8% loss in the ST group over 26 weeks (F = 8.3, P = .006). Change in memory was a significant predictor of declining instrumental activities of daily living performance (r = 0.28, 95% confidence interval = 0.08 ∞, P = .01). Informal caregiver time was not different between the AEx and ST groups. Our analysis extends recent work by revealing specific benefits for instrumental activities of daily living for individuals in the early stages of AD and supports the value of exercise for individuals with cognitive impairment.

  13. Performance of four-stage thermoelectric cooler for extended wavelength InGaAs detectors

    Science.gov (United States)

    Mo, De-feng; Yang, Li-yi; Liu, Da-fu; Xu, Qin-fei; Li, Tao; Li, Xue

    2015-04-01

    Experimental setup for evaluating four-stage thermoelectric cooler's performance was designed. Effects of input power, heat dissipation condition and heat load on the temperature difference (ΔT) of four-stage thermoelectric coolers' hot and cold faces were obtained experimentally. The result shows that, the ΔT increases as the input power increases. A linear relationship exists between input current and feedback voltage. In different cooling conditions, the ΔT of thermoelectric cooler (TEC) increases with the temperature of hot face. As the temperature increasing on hot face is 1K, the ΔT increasing of TEC can be about 0.5K. Meanwhile, the power consumption of TEC also increases slightly. Water condensation can be prevented in either dry nitrogen environment or vacuum environment, but the vacuum level has great influence to the ΔT, especially in low operation temperature. The better the vacuum level is, the smaller the convection heat loss has. When the operation temperature of focal plane array (FPA) is lower than 220K, it is prior to use vacuum packaging. Considering the Joule-heat of readout circuit and the heat loss of wire conduction, the minimum working temperature of FPA can reach below 200 K when the temperature of the hot face is 285K. And the coefficient of performance (COP) of TEC can increase sharply from 0.8% to 4% when the controlled operation temperature is 220K rather than 200K.

  14. Improving the performance of LOX/kerosene upper stage rocket engines

    Directory of Open Access Journals (Sweden)

    IgorN. Nikischenko

    2017-09-01

    Full Text Available Improved liquid rocket engine cycles were proposed and analyzed via comparison with existing staged combustion and gas-generator cycles. The key features of the proposed cycles are regenerative cooling of thrust chamber by oxygen and subsequent use of this oxygen for driving one or two oxygen pumps. The fuel pump(s are driven in a conventional manner, for example, using a fuel-rich gas-generator cycle. Comparison with staged combustion cycle based on oxygen-rich pre-burner showed that one of the proposed semi-expander cycles has a specific impulse only on 0.4% lower while providing much lower oxygen temperature, more efficient tank pressurizing system and built-in roll control. This semi-expander cycle can be considered as a more reliable and cost-effective alternative of staged combustion cycle. Another semi-expander cycle can be considered as an improvement of gas-generator cycle. All proposed semi-expander cycles were developed as a derivative of thrust chamber regenerative cooling performed by oxygen. Analysis of existing oxygen/kerosene engines showed that replacing of kerosene regenerative cooling with oxygen allows a significant increase of achievable specific impulse, via optimization of mixture ratio. It is especially the case for upper stage engines. The increasing of propellants average density can be considered as an additional benefit of mixture ratio optimization. It was demonstrated that oxygen regenerative cooling of thrust chamber is a feasible and the most promising option for oxygen/kerosene engines. Combination of oxygen regenerative cooling and semi-expander cycles potentially allows creating the oxygen/kerosene propulsion systems with minimum specific impulse losses. It is important that such propulsion systems can be fully based on inherited and well-proven technical solutions. A hypothetic upper stage engine with thrust 19.6 kN was chosen as a prospective candidate for theoretical analysis of the proposed semi

  15. Current status and prospects for in-feed antibiotics in the different stages of pork production — A review

    Directory of Open Access Journals (Sweden)

    Junyou Li

    2017-12-01

    Full Text Available Antibiotics have long been of great benefit for people, both in the medical treatment of human disease and in animal food where they improve the growth performance and feed utilization during animal production. Antibiotics as in-feed supplements affect all stages of pork production, including the gestation, nursing, growing, and finishing stages, although the effects show stage-dependent differences. However, the use of antibiotics in animal feed has become a worldwide concern. This review describes why sub-therapeutic levels of antibiotic additives in animal feed have become an integral part of animal feeding programs for more than 70 years, particularly in pork production. It also discusses the threat of the long-term use of sub-therapeutic levels of antibiotics in pork production. In recent years, the effectiveness of in-feed antibiotics has tended to decrease. This review analyzes this change from various perspectives. First, the equipment used at pig farms has improved dramatically and is more sanitary. Worldwide, more pig farms use pig farrowing crates, gestation crates, piglet nursery crates, flooring devices, piggery ventilation and cooler systems, automatic pig feeders, piggery heating equipment, and artificial insemination systems. In addition, scientists have replaced the use of antibiotics with organic acids, fermented mash, probiotics, prebiotics, minerals, oligosaccharides, enzymes, herbs/flavors, and protein/amino acids, and have improved management and husbandry techniques. In addition, animal welfare legislation has been aimed at improving the quality of the floors and living space, ensuring that animals have permanent access to fresh water, and setting a minimum weaning age. Finally, the prospects and the possibility of replacing antibiotics in pork production are described, in line with recent research results.

  16. Current status and prospects for in-feed antibiotics in the different stages of pork production - A review.

    Science.gov (United States)

    Li, Junyou

    2017-12-01

    Antibiotics have long been of great benefit for people, both in the medical treatment of human disease and in animal food where they improve the growth performance and feed utilization during animal production. Antibiotics as in-feed supplements affect all stages of pork production, including the gestation, nursing, growing, and finishing stages, although the effects show stage-dependent differences. However, the use of antibiotics in animal feed has become a worldwide concern. This review describes why sub-therapeutic levels of antibiotic additives in animal feed have become an integral part of animal feeding programs for more than 70 years, particularly in pork production. It also discusses the threat of the long-term use of sub-therapeutic levels of antibiotics in pork production. In recent years, the effectiveness of in-feed antibiotics has tended to decrease. This review analyzes this change from various perspectives. First, the equipment used at pig farms has improved dramatically and is more sanitary. Worldwide, more pig farms use pig farrowing crates, gestation crates, piglet nursery crates, flooring devices, piggery ventilation and cooler systems, automatic pig feeders, piggery heating equipment, and artificial insemination systems. In addition, scientists have replaced the use of antibiotics with organic acids, fermented mash, probiotics, prebiotics, minerals, oligosaccharides, enzymes, herbs/flavors, and protein/amino acids, and have improved management and husbandry techniques. In addition, animal welfare legislation has been aimed at improving the quality of the floors and living space, ensuring that animals have permanent access to fresh water, and setting a minimum weaning age. Finally, the prospects and the possibility of replacing antibiotics in pork production are described, in line with recent research results.

  17. Thermodynamic performance of multi-stage gradational lead screw vacuum pump

    Science.gov (United States)

    Zhao, Fan; Zhang, Shiwei; Sun, Kun; Zhang, Zhijun

    2018-02-01

    As a kind of dry mechanical vacuum pump, the twin-screw vacuum pump has an outstanding pumping performance during operation, widely used in the semiconductor industry. Compared with the constant lead screw (CLS) vacuum pump, the gradational lead screw (GLS) vacuum pump is more popularly applied in recent years. Nevertheless, not many comparative studies on the thermodynamic performance of GLS vacuum pump can be found in the literature. Our study focuses on one type of GLS vacuum pump, the multi-stage gradational lead screw (MGLS) vacuum pump, gives a detailed description of its construction and illustrates it with the drawing. Based on the structural analysis, the thermodynamic procedure is divided into four distinctive processes, including sucking process, transferring (compressing) process, backlashing process and exhausting process. The internal mechanism of each process is qualitatively illustrated and the mathematical expressions of seven thermodynamic parameters are given under the ideal situation. The performance curves of MGLS vacuum pump are plotted by MATLAB software and compared with those of the CLS vacuum pump in the same case. The results can well explain why the MGLS vacuum pump has more favorable pumping performance than the CLS vacuum pump in saving energy, reducing noise and heat dissipation.

  18. Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status.

    Science.gov (United States)

    Ishiguro, Takashi; Kagiyama, Naho; Uozumi, Ryuji; Odashima, Kyuto; Kurashima, Kazuyoshi; Morita, Satoshi; Takayanagi, Noboru

    2016-10-01

    Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015. We included 424 patients aged 68.9 ± 14.1 years in the study, of which 68.9% were men. A multivariate analysis found that advanced age (≥65 years), diabetes mellitus, and poor performance status were independent factors associated with severity, whereas old pulmonary tuberculosis, poor performance status, pneumococcal bacteremia, and severe pneumonia were independent factors that were associated with non-survival. Poor performance status was associated with the severity and mortality of pneumococcal pneumonia. Copyright © 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  19. Staged cost optimization of urban storm drainage systems based on hydraulic performance in a changing environment

    Directory of Open Access Journals (Sweden)

    M. Maharjan

    2009-04-01

    Full Text Available Urban flooding causes large economic losses, property damage and loss of lives. The impact of environmental changes, mainly urbanization and climatic change, leads to increased runoff and peak flows which the drainage system must be able to cope with to reduce potential damage and inconvenience. Allowing for detention storage to compliment the conveyance capacity of the drainage system network is one of the approaches to reduce urban floods. Contemporary practice is to design systems against stationary environmental forcings – including design rainfall, landuse, etc. Due to the rapid change in the climate- and the urban environment, this approach is no longer appropriate, and explicit consideration of gradual changes during the life-time of the drainage system is warranted. In this paper, a staged cost optimization tool based on the hydraulic performance of the drainage system is presented. A one dimensional hydraulic model is used for hydraulic evaluation of the network together with a genetic algorithm based optimization tool to determine optimal intervention timings and responses over the analysis period. The model was applied in a case study area in the city of Porto Alegre, Brazil. It was concluded that considerable financial savings and/or additional level of flood-safety can be achieved by approaching the design problem as a staged plan rather than one-off scheme.

  20. Towards a novel model for studying the nutritional stage dynamics of the Colombian population by age and socioeconomic status.

    Science.gov (United States)

    Meisel, Jose D; Sarmiento, Olga L; Olaya, Camilo; Lemoine, Pablo D; Valdivia, Juan A; Zarama, Roberto

    2018-01-01

    Low-and middle-income countries (LMICs) are experiencing a nutritional transition in which the burden of obesity tends to shift towards the lower-socioeconomic status (SES) group. We propose a system dynamics (SD) model for assessing the nutritional stage dynamics of the Colombian urban population by age and SES projected to 2030. This SD model captures the ageing population according to body mass index (BMI) categories and SES. In this model, the transference rates (TRs) between BMI categories by age and SES are estimated using a heuristic based on data obtained from national surveys. The simulation results show that the Colombian population, particularly those aged 20 to 39 years with a lower SES, is moving towards the overweight and obese categories. The TRs for overweight and obese categories in the lower SES group (the mean TR from not overweight to overweight = 0.0215 (per year) and mean TR from overweight to obese = 0.0098 (per year)) are increasing more rapidly than the those in the middle (the mean TR from not overweight to overweight = 0.0162 (per year) and mean TR from overweight to obese = 0.0065 (per year)) and higher SES groups (the mean TR from not overweight to overweight = 0.0166 and mean TR from overweight to obese = 0.0054 (per year)). Additionally, from 2005 to 2010, individuals aged 20 to 39 years had the highest TRs towards the overweight and obese categories (from 0.026 to 0.036 per year and from 0.0064 to 0.012 per year, respectively). The TRs also indicated that children aged 0 to 14 years are moving from the obese to overweight and from the overweight to not overweight categories. These TRs show that the Colombian population is experiencing an SES-related nutritional transition that is affecting the lower SES population. The proposed model could be implemented to assess the nutritional transitions experienced in other LMICs.

  1. Enhancing human performance in ship operations by modifying global design factors at the design stage

    International Nuclear Information System (INIS)

    Montewka, Jakub; Goerlandt, Floris; Innes-Jones, Gemma; Owen, Douglas; Hifi, Yasmine; Puisa, Romanas

    2017-01-01

    Usually the improvements of human performance in the course of ship design process is carried out by modifying local ergonomics, like electronic visualisation and information display systems on the bridge or in the engine control room, stair or hatch covers design. However, the effect of global design factors (GDFs), such as ship motion, whole body vibration and noise, on human performance has not been given attention before. Such knowledge would allow the improvements of human performance by effective design modification on very early stage of ship design process. Therefore, in this paper we introduce probabilistic models linking the effect of GDFs with the human performance suitable for ship design process. As a theoretical basis for modelling human performance the concept of Attention Management is utilized, which combines the theories described by Dynamic Adaptability Model, Cognitive Control Model and Malleable Attentional Resources Theory. Since the analysed field is characterised by a high degree of uncertainty, we adopt a specific modelling technique along with a validation framework that allows uncertainty treatment and helps the potential end-users to gain confidence in the models and the results that they yield. The proposed models are developed with the use Bayesian Belief Networks, which allows systematic translation of the available background knowledge into a coherent network and the uncertainty assessment and treatment. The obtained results are promising as the models are responsive to changes in the GDF nodes as expected. The models may be used as intended by naval architects and vessel designers, to facilitate risk-based ship design. - Highlights: • Models linking the effect of GDFs with the human performance are established. • Three global design factors (GDFs) are considered: ship motion, body vibration, noise. • Attention Management concept as theoretical base is modelled with Bayesian Networks. • Two models are developed that can be

  2. Difference of stage at cancer diagnosis by socioeconomic status for four target cancers of the National Cancer Screening Program in Korea: Results from the Gwangju and Jeonnam cancer registries.

    Science.gov (United States)

    Kweon, Sun-Seog; Kim, Min-Gyeong; Kang, Mi-Ran; Shin, Min-Ho; Choi, Jin-Su

    2017-07-01

    The aim of this study was to evaluate whether stage at cancer diagnosis differed according to patient economic status. A total of 10,528 patients with cancer of the stomach, colorectum, breast, or cervix, which are target organs of the Korean National Cancer Screening Program (NCSP; fully implemented in 2005) were extracted from population-based cancer registries. The patients were classified into four groups based on socioeconomic status (SES), as determined using their National Health Insurance (NHI) monthly premium at the time of cancer diagnosis. Cancer stage at diagnosis was defined as early (in situ/local) or late stage (regional/distant) based on the Surveillance, Epidemiology, and End Results (SEER) summary stage. Multivariable logistic regression analysis was performed to estimate the risk of non-local stage using age, residential area, and community deprivation index as covariates. The lowest SES subjects showed significantly higher risks of being diagnosed at a later stage for stomach, colorectal, and female breast cancer, but not for cervical cancer, compared with the highest SES subjects. The estimated ORs were 1.28 (95% CI, 1.10-1.49), 1.29 (95% CI, 1.03-1.61), and 1.35 (95% CI, 1.02-1.81) in the lowest SES subjects with stomach, colorectal, and breast cancer, respectively. In conclusion, later stage diagnoses of stomach, colon, and female breast cancer are still associated with SES in Korea in the era of the NCSP for the lower SES population. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  3. [ASSOCIATION BETWEEN FITNESS, NUTRITIONAL STATUS AND ACADEMIC PERFORMANCE IN PHYSICAL EDUCATION STUDENTS].

    Science.gov (United States)

    Godoy Cumillaf, Andrés; Valdés Badilla, Pablo; Fariña Herrera, Custodio; Cárcamo Mora, Francisco; Medina Herrera, Bernice; Meneses Sandoval, Elías; Gedda Muñoz, Relmu; Durán Agüero, Samuel

    2015-10-01

    several studies demonstrated that regular physical exercise would impact positively on the academic performance of students. to determine the association between physical fitness, nutritional status and academic performance of students of Pedagogy in Physical Education from Temuco, Chile. the sample was selected on a non-probabilistic approach, which included 208 subjects (n = 153 women and n = 55 women). The variables studied were physical fitness (short Abs, long jump with feet together, forward trunk flexion, elbow flexion and extension and "course navette" test), nutritional status (BMI) and academic performance (classified as up and down the academic average). 87.5% of students have a satisfactory fitness and a BMI of 23.8 ± 2.9 kg/m2. The students with the best academic performance were those with the higher proportion of satisfactory physical condition (92.5 %). No association between academic performance and nutritional status was determined, but it was observed between low fitness and a great risk of low academic performance (OR = 2.8, 95% CI 1.0 to 8 1; p academic achievement and physical fitness among students is observed, but no for the nutritional status and the academic performance. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  4. The association of iron status with educational performance and intelligence among adolescents.

    Science.gov (United States)

    Dissanayake, D S; Kumarasiri, P V R; Nugegoda, D B; Dissanayake, D M

    2009-09-01

    The aim was to identify the association of iron status with educational performance and intelligence of adolescents. This was a cross sectional comparative study among adolescents aged 13-15 years. Each iron deficient student was matched with an iron sufficient student from the same school, class and sex. Iron status was based on haemoglobin and serum ferritin levels. The marks for mathematics, science, Sinhala language and social science were considered to assess educational performance. Intelligence was measured by Raven's Standard progressive matrices. All the possible confounders and effect modifiers were considered. Home visits to a sub-sample checked the quality of data. The final analysis included 188 students (94 matched pairs). Neither educational performance nor intelligence showed significant associations with the iron status. The severity of the iron deficiency did not relate to these cognitive variables either. Twenty-three and 8 co-variables showed statistically significant associations with educational performance and intelligence respectively. Following a multiple regression analysis intelligence, the enthusiasm of the student towards learning, occupational ambition, household possession, problems at home and private tuition for mathematics were key factors predicting educational performance. Stunting and educational level of the mother were important factors influencing intelligence. Iron status does not play a major role in educational performance and intelligence of school going adolescents. Several factors affect educational performance and intelligence. This study highlights the difficulty in extrapolating the findings of similar studies to different ecological settings.

  5. Taking the reins: the effects of new leader status and leadership style on team performance.

    Science.gov (United States)

    Sauer, Stephen J

    2011-05-01

    New leaders face a challenging task when they take charge of their teams. They have to determine how best to guide the work process, and they must understand how their behaviors will affect the members of their team. This research examines how a newly assigned team leader's status moderates subordinates' reactions to different leadership styles to affect assessments of the leader's self-confidence and effectiveness, and how this impacts team performance. Across 2 experimental studies, results demonstrate that low-status leaders are rated as more effective when they use a directive style, whereas high-status leaders are viewed as more effective when they use a participative style, and this relationship is mediated by perceptions of self-confidence. In addition, teams whose leaders are viewed more favorably perform better on a complex group task. These findings imply that low-status individuals are able to enhance their level of personal power by drawing on whatever positional power they hold, whereas high-status individuals are better off relying solely on their personal power to influence others. This research also provides a clear demonstration that assessments of new leaders' behaviors are subject to an appraisal that is clouded by observers' status perceptions and attributions.

  6. Status of treatment for the overall population of patients with stage IVb endometrial cancer, and evaluation of the role of preoperative chemotherapy: a retrospective multi-institutional study of 426 patients in Japan.

    Science.gov (United States)

    Eto, Takako; Saito, Toshiaki; Shimokawa, Mototsugu; Hatae, Masayuki; Takeshima, Nobuhiro; Kobayashi, Hiroaki; Kasamatsu, Takahiro; Yoshikawa, Hiroyuki; Kamura, Toshiharu; Konishi, Ikuo

    2013-12-01

    We previously reported on the role of cytoreduction in 248 patients with surgical stage IVb endometrial cancer (EMCA). This study aimed to evaluate the clinical characteristics, prognosis according to initial treatment, and impact of preoperative chemotherapy in the overall population of patients with clinical and surgical stage IVb EMCA. A multi-institutional retrospective analysis was performed in 426 patients diagnosed with clinical and surgical stage IVb EMCA from 1996 to 2005. Factors associated with overall survival (OS) were identified using univariate and multivariate analyses. The median OS for all 426 patients was 14 months. Patients were divided into three groups according to their initial treatment: primary surgery group (n=279), primary chemotherapy group (n=125), and palliative care group (n=22). The median OS times for these groups were 21, 12, and 1 month, respectively (p<0.0001). Patients in the primary surgery group had better performance status (PS) and lower numbers of extra-abdominal metastases than those in the primary chemotherapy group. Multivariate analysis identified good PS, endometrioid histology, absence of clinical intra-abdominal stage IVb metastasis, hysterectomy, and chemotherapy as independent predictors of OS. In the primary chemotherapy group, 59 patients subsequently underwent surgery, and these patients had similar OS to those in the primary surgery group. Hysterectomy and chemotherapy may prolong OS in selected patients with stage IVb EMCA. Our data suggest that primary chemotherapy followed by surgery may be a useful treatment choice in patients not suitable for primary surgery. © 2013.

  7. Age-specific influences of emotional distress on performance status in cancer patients.

    Science.gov (United States)

    Kim, Ji-Hyun; Yoon, Sujung; Won, Wang-Youn; Lee, Chul; Lee, Chang-Uk; Song, Kyo Young; Min, Jung-Ah; Lyoo, In Kyoon; Kim, Tae-Suk

    2013-10-01

    Improving and maintaining performance status is an important part of cancer treatment because it may predict patients' survival. Several cancer-related medical conditions have been known to influence the functional performance of cancer patients. We here examined whether emotional distress would also contribute to performance decline of cancer patients. With consecutive sampling, a total of 880 patients diagnosed as having cancer were recruited and evaluated on cancer-related variables, emotional distress, and performance status using the standardized instruments. Approximately 8.9% of participants showed compromised performance rated 2 or more on the Eastern Cooperative Oncology Group performance status scale. Emotional distress was strongly associated with compromised performance after controlling for demographic and cancer-related external risk factors. The effects of emotional distress on performance decline were likely to be remarkably greater in the younger age group (emotional distress on having a higher risk for performance decline in cancer patients. These effects seem to be age-dependent suggesting that special clinical attention to emotional distress may be required in younger patients with cancer. Copyright © 2013 John Wiley & Sons, Ltd.

  8. Nutritional status, physical performance and disability in the elderly of the Peruvian Andes.

    Science.gov (United States)

    Tramontano, Alessandra; Veronese, Nicola; Giantin, Valter; Manzato, Enzo; Rodriguez-Hurtado, Diana; Trevisan, Caterina; De Zaiacomo, Francesca; Sergi, Giuseppe

    2016-12-01

    Although nutritional status plays an important part in the physical performance and disability of older people, this relationship has been little studied in developing countries. A study on the effects of nutritional status on the physical performance and functional status of elderly people living in rural areas of the Peruvian Andes. The study concerned 222 people aged ≥65 years living in a rural area of the Peruvian Andes. The Mini-Nutritional Assessment (MNA) was used to classify participants as malnourished (MNA = 24). The short physical performance battery (SPPB) and six-minute walking test (6MWT) were used to measure participants' physical performance. Disabilities were investigated by assessing participants' self-reported difficulty in performing one or more basic activities of daily living (ADL), and instrumental activities of daily living (IADL). The prevalence of malnutrition was 9.4 %, and more than half of our samples were at risk of malnutrition. After adjusting for potential confounders, malnourished individuals performed significantly worse than the other MNA groups in the SPPB (p for trend=0.001), 6MWT and IADL (p for trend disability in IADL (OR 5.36, 95 % CI 1.02-56.94; p = 0.05), and poor performance in the 6MWT (OR 2.73, 95 % CI 1.06-12.08; p = 0.03) and SPPB (OR 4.94, 95 % CI 1.01-24.07; p = 0.04). Poor nutritional status was found significantly associated with poor physical performance and poor functional status in elderly Peruvian individuals.

  9. Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status

    Directory of Open Access Journals (Sweden)

    Wei Jun S

    2011-04-01

    Full Text Available Abstract Background Neuroblastoma (NB tumors are well known for their pronounced clinical and molecular heterogeneity. The global gene expression and DNA copy number alterations have been shown to have profound differences in tumors of low or high stage and those with or without MYCN amplification. RNA splicing is an important regulatory mechanism of gene expression, and differential RNA splicing may be associated with the clinical behavior of a tumor. Methods In this study, we used exon array profiling to investigate global alternative splicing pattern of 47 neuroblastoma samples in stage 1 and stage 4 with normal or amplified MYCN copy number (stage 1-, 4- and 4+. The ratio of exon-level expression to gene-level expression was used to detect alternative splicing events, while the gene-level expression was applied to characterize whole gene expression change. Results Principal component analysis (PCA demonstrated distinct splicing pattern in three groups of samples. Pairwise comparison identified genes with splicing changes and/or whole gene expression changes in high stage tumors. In stage 4- compared with stage 1- tumors, alternatively spliced candidate genes had little overlap with genes showing whole gene expression changes, and most of them were involved in different biological processes. In contrast, a larger number of genes exhibited either exon-level splicing, gene-level expression or both changes in stage 4+ versus stage 1- tumors. Those biological processes involved in stage 4- tumors were disrupted to a greater extent by both splicing and transcription regulations in stage 4+ tumors. Conclusions Our results demonstrated a significant role of alternative splicing in high stage neuroblastoma, and suggested a MYCN-associated splicing regulation pathway in stage 4+ tumors. The identification of differentially spliced genes and pathways in neuroblastoma tumors of different stages and molecular subtypes may be important to the

  10. Cardiorespiratory fitness and academic performance association is mediated by weight status in adolescents: DADOS study.

    Science.gov (United States)

    Beltran-Valls, María Reyes; Adelantado-Renau, Mireia; Castro-Piñero, Jose; Sánchez-López, Mairena; Moliner-Urdiales, Diego

    2018-04-28

    The aim of our study was to examine the mediation effect of weight status on the association between cardiorespiratory fitness (CRF) and academic performance (AP). Two hundred sixty-nine adolescents (140 boys) aged 13.9 ± 0.3 years old from the DADOS study were included in this cross-sectional analysis. CRF was assessed by the 20-m shuttle run test and estimated maximum oxygen uptake was used in the analysis. AP was assessed through the final academic grades and the Science Research Associates Test of Educational Abilities for assessing reasoning, verbal, and numeric abilities. Weight status was assessed by body mass index (kg/m 2 ). Boot-strapped mediation procedures were performed and indirect effects (IE) with confidence intervals (CI) not including zero were considered statistically significant. Mediation analysis revealed that weight status acted as a mediator of the relationship of CRF with reasoning ability (IE = 0.039; CI = 0.001; 0.091) and the final grades in Math (IE = 0.011; CI = 0.002; 0.025), Language (IE = 0.013; CI = 0.004; 0.027), and GPA (IE = 0.011; CI = 0.003; 0.023). Our data show that the influence of CRF on academic performance is mediated by weight status in adolescents. We suggest that our data could be considered by educators, families, and policy makers, so that active lifestyles might be promoted when designing programs aimed to improve AP among adolescents. What is Known: • Academic performance is associated with both, cardiorespiratory fitness and weight status. • The role of weight status in the association between cardiorespiratory fitness and academic performance is poorly understood. What is New: • We support the scarce research investigating the mediating role of weight status as mechanism in the association between fitness and academic performance in youth. • Previous knowledge is expanded by suggesting that cardiorespiratory fitness is related to weight status which in turn may

  11. Relative performance of two-stage continual reassessment method in contrast to an optimal benchmark

    Science.gov (United States)

    Wages, Nolan A.; Conaway, Mark R.; O’Quigley, John

    2015-01-01

    Background The two-stage, likelihood-based continual reassessment method (CRM-L; O’Quigley and Shen [1]) entails the specification of a set of design parameters prior to the beginning of its use in a study. The impression of clinicians is that the success of model-based designs, such as CRM-L, depends upon some of the choices made in regard to these specifications, such as the choice of parametric dose-toxicity model and the initial guess of toxicity probabilities. Purpose In studying the efficiency and comparative performance of competing dose-finding designs for finite (typically small) samples, the non-parametric optimal benchmark (O’Quigley, Paoletti and Maccario [2]) is a useful tool. When comparing a dose-finding design to the optimal design, we are able to assess how much room there is for potential improvement. Methods The optimal method, based only on an assumption of monotonicity of the dose-toxicity function, is a valuable theoretical construct serving as a benchmark in theoretical studies, similar to that of a Cramer-Rao bound. We consider the performance of CRM-L under various design specifications and how it compares to the optimal design across a range of practical situations. Results Using simple recommendations for design specifications, the CRM-L will produce performances, in terms of identifying doses at and around the MTD, that are close to the optimal method on average over a broad group of dose-toxicity scenarios. Limitations Although the simulation settings vary the number of doses considered, the target toxicity rate and the sample size, the results here are presented for a small, though widely-used, set of two-stage CRM designs. Conclusions Based on simulations here, and many others not shown, CRM-L is almost as accurate, in many scenarios, as the (unknown and unavailable) optimal design. On average, there appears to be very little margin for improvement. Even if a finely tuned skeleton [3] offers some improvement over a simple skeleton

  12. Design concept of a pump stage with replaceable hydraulic components and prediction of its performance curves

    International Nuclear Information System (INIS)

    Lugova, S O; Knyazeva, E G; Tverdokhleb, I B; Kochevsky, A N

    2010-01-01

    In many cases, centrifugal pump units are expected to deliver the required performance under varying operating conditions. In particular, the pumps for oil extraction and transportation should deliver a constant head, although their capacity often changes during the life cycle. In order to keep the efficiency at a high level and not to replace a whole pump, the authors suggest to replace in such cases only hydraulic components of the pump (impellers and stationary sections of diffuser channels) that are to be installed in the same casing. The paper describes an approach for designing of radial-flow impellers and sections of diffuser channels to be used as replaceable. It allows for delivering a required head and providing a high efficiency in a wide range of capacities. The components intended for smaller capacities are featured with narrower flow passages. However, the dimensions of replaceable components are the same. The paper describes also a numerical simulation of fluid flow in a pump stage with two sets of replaceable radial-flow impellers and sections of diffuser channels. The CFD software used in this research is ANSYS CFX 11. Good correspondence of results is observed. Difference in flow pattern at various capacities and its influence on the performance curves delivered with replaceable components is demonstrated. Basing on the obtained results, the analysis of energy losses is presented.

  13. Performance test of a 6-stage continuous reactor for palm methyl ester production.

    Science.gov (United States)

    Leevijit, T; Tongurai, C; Prateepchaikul, G; Wisutmethangoon, W

    2008-01-01

    Effects of residence time (3-12 min), stirrer speed (0-800 rpm), and NaOH concentration (0.25-1.0 wt% of oil) on the production performance of the designed 6-stage continuous reactor (2.272 l) for transesterification of palm oil were investigated at molar ratio of methanol to oil of 6:1 and temperature of 60 degrees C. Higher stirrer speed increased the reaction rate up to an appropriate speed but excessive stirrer speed decreased the reaction rate. Inappropriate stirrer speed runs dramatically decreased the production capacity of the reactor. Higher NaOH concentration significantly increased reaction rate and production capacity of the reactor. The reactor had a residence time distribution equivalent to 5.98 ideal CSTRs in series and a production performance equivalent to a plug flow reactor. At NaOH of 1.0 wt% of oil, the reactor could produce saleable biodiesel within residence time of 6 min in which a production capacity was 17.3 l/h and a power consumption of stirrer was 0.6 kW/m(3).

  14. Experimental study on combustion modes and thrust performance of a staged-combustor of the scramjet with dual-strut

    Science.gov (United States)

    Yang, Qingchun; Chetehouna, Khaled; Gascoin, Nicolas; Bao, Wen

    2016-05-01

    To enable the scramjet operate in a wider flight Mach number, a staged-combustor with dual-strut is introduced to hold more heat release at low flight Mach conditions. The behavior of mode transition was examined using a direct-connect model scramjet experiment along with pressure measurements. The typical operating modes of the staged-combustor are analyzed. Fuel injection scheme has a significant effect on the combustor operating modes, particularly for the supersonic combustion mode. Thrust performances of the combustor with different combustion modes and fuel distributions are reported in this paper. The first-staged strut injection has a better engine performance in the operation of subsonic combustion mode. On the contrast, the second-staged strut injection has a better engine performance in the operation of supersonic combustion mode.

  15. The influence of Thomson effect in the performance optimization of a two stage thermoelectric cooler

    Science.gov (United States)

    Kaushik, S. C.; Manikandan, S.

    2015-12-01

    The exoreversible and irreversible thermodynamic models of a two stage thermoelectric cooler (TTEC) considering Thomson effect in conjunction with Peltier, Joule and Fourier heat conduction effects have been investigated using exergy analysis. New expressions for the interstage temperature, optimum current for the maximum cooling power, energy and exergy efficiency conditions, energy efficiency and exergy efficiency of a TTEC are derived as well. The number of thermocouples in the first and second stages of a TTEC for the maximum cooling power, energy and exergy efficiency conditions are optimized. The results show that the exergy efficiency is lower than the energy efficiency e.g., in an irreversible TTEC with total 30 thermocouples, heat sink temperature (TH) of 300 K and heat source temperature (TC) of 280 K, the obtained maximum cooling power, maximum energy and exergy efficiency are 20.37 W, 0.7147 and 5.10% respectively. It has been found that the Thomson effect increases the cooling power and energy efficiency of the TTEC system e.g., in the exoreversible TTEC the cooling power and energy efficiency increased from 14.87 W to 16.36 W and from 0.4079 to 0.4998 respectively for ΔTC of 40 K when Thomson effect is considered. It has also been found that the heat transfer area at the hot side of an irreversible TTEC should be higher than the cold side for maximum performance operation. This study will help in the designing of the actual multistage thermoelectric cooling systems.

  16. Influences of flow loss and inlet distortions from radial inlets on the performances of centrifugal compressor stages

    Energy Technology Data Exchange (ETDEWEB)

    Han, Feng Hui; Mao, Yi Jun [School of Energy and Power Engineering, Xi' an Jiaotong University, Xi' an (China); Tan, Ji Jian [Dept. of Research and Development, Shenyang Blower Works Group Co., Ltd., Shenyang (China)

    2016-11-15

    Radial inlets are typical upstream components of multistage centrifugal compressors. Unlike axial inlets, radial inlets generate additional flow loss and introduce flow distortions at impeller inlets. Such distortions negatively affect the aerodynamic performance of compressor stages. In this study, industrial centrifugal compressor stages with different radial inlets are investigated via numerical simulations. Two reference models were built, simulated, and compared with each original compressor stage to analyze the respective and coupling influences of flow loss and inlet distortions caused by radial inlets on the performances of the compressor stage and downstream components. Flow loss and inlet distortions are validated as the main factors through which radial inlets negatively affect compressor performance. Results indicate that flow loss inside radial inlets decreases the performance of the whole compressor stage but exerts minimal effect on downstream components. By contrast, inlet distortions induced by radial inlets negatively influence the performance of the whole compressor stage and exert significant effects on downstream components. Therefore, when optimizing radial inlets, the reduction of inlet distortions might be more effective than the reduction of flow loss. This research provides references and suggestions for the design and improvement of radial inlets.

  17. Performance assessment and transient optimization of multi-stage solid desiccant air conditioning systems with building PV/T integration

    Science.gov (United States)

    Gadalla, Mohamed; Saghafifar, Mohammad

    2016-09-01

    One of the popular solar air conditioning technologies is desiccant air conditioning. Nonetheless, single stage desiccant air conditioning systems' coefficient of performance (COP) are relatively low. Therefore, multi-stage solid desiccant air conditioning systems are recommended. In this paper, an integrated double-stage desiccant air conditioning systems and PV/T collector is suggested for hot and humid climates such as the UAE. The results for the PV/T implementation in the double-stage desiccant cooling system are assessed against the PV/T results for a single-stage desiccant air conditioning system. In order to provide a valid comparative evaluation between the single and double stage desiccant air conditioning systems, an identical PV/T module, in terms of dimensions, is incorporated into these systems. The overall required auxiliary air heating is abated by 46.0% from 386.8 MWh to 209.0 MWh by replacing the single stage desiccant air conditioning system with the proposed double stage configuration during June to October. Moreover, the overall averaged solar share during the investigated months for the single and double stage systems are 36.5% and 43.3%.

  18. Performance of real-time elastography for the staging of hepatic fibrosis: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Huisuo Hong

    Full Text Available BACKGROUND: With the rapid development of real-time elastography (RTE, a variety of measuring methods have been developed for the assessment of hepatic fibrosis. We evaluated the overall performance of four methods based on RTE by performing meta-analysis of published literature. METHODS: Online journal databases and a manual search from April 2000 to April 2014 were used. Studies from different databases that meet inclusion criteria were enrolled. The statistical analysis was performed using a random-effects model and fixed-effects model for the overall effectiveness of RTE. The area under the receiver operating characteristic curve (AUROC was calculated for various means. Fagan plot analysis was used to estimate the clinical utility of RTE, and the heterogeneity of the studies was explored with meta-regression analysis. RESULTS: Thirteen studies from published articles were enrolled and analyzed. The combined AUROC of the liver fibrosis index (LFI for the evaluation of significant fibrosis (F≥2, advanced fibrosis (F≥3, and cirrhosis (F = 4 were 0.79, 0.94, and 0.85, respectively. The AUROC of the elasticity index (EI ranged from 0.75 to 0.92 for F≥2 and 0.66 to 0.85 for F = 4. The overall AUROC of the elastic ratio of the liver for the intrahepatic venous vessels were 0.94, 0.93, and 0.96, respectively. The AUROC of the elastic ratio of the liver for the intercostal muscle in diagnosing advanced fibrosis and cirrhosis were 0.96 and 0.92, respectively. There was significant heterogeneity in the diagnostic odds ratio (DOR for F≥2 of LFI mainly due to etiology (p<0.01. CONCLUSION: The elastic ratio of the liver for the intrahepatic vein has excellent precision in differentiating each stage of hepatic fibrosis and is recommend to be applied to the clinic.

  19. Longitudinal study of repeated sprint performance in youth soccer players of contrasting maturity status

    NARCIS (Netherlands)

    V. Duarte; J. Valente dos Santos; V. Severino; Marije Elferink-Gemser; R. Philippaerts; M. Coelho e Silva; A. Seabra; A. Figueiredo; S. Cumming; R. Martins

    2012-01-01

    The purpose of the study was to evaluate the developmental changes in performance in a repeated-sprint ability (RSA) test in young soccer players of contrasting maturity status. A total of 83 regional level Portuguese youth soccer players, aged 11- 13 years at baseline was assessed annually.

  20. Longitudinal study of repeated sprint performance in youth soccer players of contrasting skeletal maturity status

    NARCIS (Netherlands)

    Valente-dos-Santos, Joao; Coelho-e-Silva, Manuel J.; Severino, Vitor; Duarte, Joao; Martins, Raul S.; Figueiredo, Antonio J.; Seabra, Andre T.; Philippaerts, Renaat M.; Cumming, Sean P.; Elferink-Gemser, Marije; Malina, Robert M.

    The purpose of the study was to evaluate the developmental changes in performance in a repeated-sprint ability (RSA) test in young soccer players of contrasting maturity status. A total of 83 regional level Portuguese youth soccer players, aged 11-13 years at baseline was assessed annually. Stature,

  1. Does Socioeconomic Status Explain the Relationship between Admissions Tests and Post-Secondary Academic Performance?

    Science.gov (United States)

    Sackett, Paul R.; Kuncel, Nathan R.; Arneson, Justin J.; Cooper, Sara R.; Waters, Shonna D.

    2009-01-01

    Critics of educational admissions tests assert that tests measure nothing more than socioeconomic status (SES) and that their apparent validity in predicting academic performance is an artifact of SES. The authors examined multiple large data sets containing data on admissions and related tests, SES, and grades showing that (a) SES is related to…

  2. From Social Class to Self-Efficacy: Internalization of Low Social Status Pupils' School Performance

    Science.gov (United States)

    Wiederkehr, Virginie; Darnon, Céline; Chazal, Sébastien; Guimond, Serge; Martinot, Delphine

    2015-01-01

    Previous research has largely documented that socioeconomic status (SES) is a strong and consistent predictor of pupils' school performance in several countries. In this research, we argue that children internalize the SES achievement gap in the form of a lower/higher sense of school self-efficacy. In two studies, teenaged students' (Study 1) and…

  3. Academic performance of Korean children is associated with dietary behaviours and physical status.

    Science.gov (United States)

    Kim, Hye-Young P; Frongillo, Edward A; Han, Sung-Sook; Oh, Se-Young; Kim, Woo-Kyung; Jang, Young-Ai; Won, Hye-Sook; Lee, Hyun-Sook; Kim, Sook-He

    2003-01-01

    The purpose of this study was to obtain a fuller understanding of the association of dietary behaviours, physical status and socio-economic status with academic performance in Korean teenagers. The subjects in this study were 6,463 boys and girls, in grade 5, 8, and 11 in Korea. A self-administered questionnaire and the food-frequency form were used. Grade point average (GPA), height, weight, and physical fitness score for the year were recorded from the school record. The academic performance of students was strongly associated with dietary behaviours, especially with regularity of three meals even after control for parent's education level. Regular breakfast and lunch were more important in grades 5 and 8, while regular dinner was more related with academic performance in grade 11. Small, positive associations of height and physical fitness to academic performance were also found. The relative importance of regularity of meals was greater than that of socio-economic status and physical status in older teenagers. The results of this study suggest that accommodation of better dietary environment and nutrition education for three regular meals is recommended.

  4. Intravenous ketogenic diet therapy for treatment of the acute stage of super-refractory status epilepticus in a pediatric patient.

    Science.gov (United States)

    Lin, Jainn-Jim; Lin, Kuang-Lin; Chan, Oi-Wa; Hsia, Shao-Hsuan; Wang, Huei-Shyong

    2015-04-01

    A ketogenic diet has been used successfully to treat intractable epilepsy. However, the role of early intravenous initiation of ketogenic diet in the acute phase of super-refractory status epilepticus is not well-described. An intravenous ketogenic diet was administered to a boy with super-refractory status epilepticus. At 24 hours after intravenous ketogenic diet, moderate ketosis appeared, and thiamylal was successfully weaned at 70 hours after admission. An intravenous ketogenic regimen led to subsequent ketosis and seizure control in a child with super-refractory status epilepticus. Early induction of ketosis may be a novel strategy to effectively treat super-refractory status epilepticus. Although there are few data regarding the early use of intravenous ketogenic diet in the treatment of super-refractory status epilepticus, it may be considered an alternative option. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Impact of Schoolchildren’s Health Status on Their Academic Performance

    Directory of Open Access Journals (Sweden)

    V.P. Nedilko

    2014-03-01

    Full Text Available The article presents the results of a comparative analysis of health status and factors of psycho-physical development of children of middle and senior school age. A comparative analysis of the state of children with high and low performance has been carried out. The problems of dependence of performance level of children on the factors of medical, psychological and pedagogical influence on their development in the school are considered.

  6. Performance of staged and non-staged up-flow anaerobic sludge bed (USSB and UASB) reactors treating low strength complex wastewater.

    Science.gov (United States)

    Sevilla-Espinosa, Susana; Solórzano-Campo, Maricela; Bello-Mendoza, Ricardo

    2010-09-01

    The use of anaerobic processes to treat low-strength wastewater has been increasing in recent years due to their favourable performance-costs balance. For optimal results, it is necessary to identify reactor configurations that are best suited for this kind of application. This paper reports on the comparative study carried out with two high-rate anaerobic reactor systems with the objective of evaluating their performances when used for the treatment of low-strength, complex wastewater. One of the systems is the commonly used up-flow anaerobic sludge blanket (UASB) reactor. The other is the up-flow staged sludge bed (USSB) system in which the reactor was divided longitudinally into 3, 5 and 7 compartments by the use of baffles. The reactors (9 l) were fed with a synthetic, soluble and colloidal waste (chemical oxygen demand (COD) flow hydraulics, between plug-flow and completely-mixed, in the UASB and 7 stages USSB reactors allowed efficient degradation of substrates with minimum effluent concentrations. Low number of compartments in the USSB reactors increased the levels of short-circuiting thus reducing substrate removal efficiencies. All reactors showed high COD removal efficiencies (93-98%) and thus can be regarded as suitable for the treatment of low strength, complex wastewater. Staged anaerobic reactors can be a good alternative for this kind of application provided they are fitted with a large enough (> or =7) number of compartments to fully take advantage of their strengths. Scale factors seem to have influenced importantly on the comparison between one and multi staged sludge-bed reactors and, therefore, observations made here could change at larger reactor volumes.

  7. Aerodynamic and Performance Behavior of a Three-Stage High Efficiency Turbine at Design and Off-Design Operating Points

    Directory of Open Access Journals (Sweden)

    M. T. Schobeiri

    2004-01-01

    Full Text Available This article deals with the aerodynamic and performance behavior of a three-stage high pressure research turbine with 3-D curved blades at its design and off-design operating points. The research turbine configuration incorporates six rows beginning with a stator row. Interstage aerodynamic measurements were performed at three stations, namely downstream of the first rotor row, the second stator row, and the second rotor row. Interstage radial and circumferential traversing presented a detailed flow picture of the middle stage. Performance measurements were carried out within a rotational speed range of 75% to 116% of the design speed. The experimental investigations have been carried out on the recently established multi-stage turbine research facility at the Turbomachinery Performance and Flow Research Laboratory, TPFL, of Texas A&M University.

  8. Nutritional Status of Patients with Chronic Obstructive Pulmonary Disease in Relation to their Physical Performance.

    Science.gov (United States)

    Matkovic, Zinka; Cvetko, Danijel; Rahelic, Dario; Esquinas, Cristina; Zarak, Marko; Miravitlles, Marc; Tudoric, Neven

    2017-12-01

    Nutritional abnormalities and physical inactivity are highly prevalent in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to determine the association between nutritional status/body composition and physical performance in patients with COPD. A cross-sectional observational study was conducted in outpatients with clinically stable, moderate to very severe COPD. In the assessment of nutritional status, we used dual energy X-ray absorptiometry, anthropometry, serum biomarkers, and the Mini-Nutritional Assessment (MNA) questionnaire. Physical performance was measured by the 6-minute walk distance (6MWD), 4-metre gait speed (4MGS), and physical activity. Univariate and multivariate analyses were performed. In 111 patients (mean age 68 years, 69% men), the mean 6MWD was 376 ± 119 m, 4MGS 0.9 ± 0.2 m/s, and the average daily step count 8,059 ± 4,757. Patients with low exercise capacity (6MWD ≤ 350 m) had a significantly lower lean mass index (LMI) (p nutritional variables showed an independent association with low physical performance in the multivariate models. In conclusion, patients with low physical performance have deficient nutritional status, but we could not demonstrate an independent relationship between nutritional parameters and physical performance.

  9. Performance analysis of a potassium-steam two stage vapour cycle

    International Nuclear Information System (INIS)

    Mitachi, Kohshi; Saito, Takeshi

    1983-01-01

    It is an important subject to raise the thermal efficiency in thermal power plants. In present thermal power plants which use steam cycle, the plant thermal efficiency has already reached 41 to 42 %, steam temperature being 839 K, and steam pressure being 24.2 MPa. That is, the thermal efficiency in a steam cycle is facing a limit. In this study, analysis was made on the performance of metal vapour/steam two-stage Rankine cycle obtained by combining a metal vapour cycle with a present steam cycle. Three different combinations using high temperature potassium regenerative cycle and low temperature steam regenerative cycle, potassium regenerative cycle and steam reheat and regenerative cycle, and potassium bleed cycle and steam reheat and regenerative cycle were systematically analyzed for the overall thermal efficiency, the output ratio and the flow rate ratio, when the inlet temperature of a potassium turbine, the temperature of a potassium condenser, and others were varied. Though the overall thermal efficiency was improved by lowering the condensing temperature of potassium vapour, it is limited by the construction because the specific volume of potassium in low pressure section increases greatly. In the combinatipn of potassium vapour regenerative cycle with steam regenerative cycle, the overall thermal efficiency can be 58.5 %, and also 60.2 % if steam reheat and regenerative cycle is employed. If a cycle to heat steam with the bled vapor out of a potassium vapour cycle is adopted, the overall thermal efficiency of 63.3 % is expected. (Wakatsuki, Y.)

  10. The Concept, Design and Performance of a Novel Rotary Kiln Type Air-Staged Biomass Gasifier

    Directory of Open Access Journals (Sweden)

    Huiyuan Shi

    2016-01-01

    Full Text Available Tar formation is the main bottleneck for biomass gasification technology. A novel rotary kiln type biomass gasification process was proposed. The concept design was based on air staging and process separation. This concept was demonstrated on a pilot scale rotary kiln reactor under ambient pressure and autothermic conditions. The pilot scale gasifier was divided into three different reaction regions, which were oxidative degradation, partial oxidation and char gasification. A series of tests was conducted to investigate the effect of key parameters. The results indicate that under optimum operating conditions, a fuel gas with high heat value of about 5500 kJ/Nm3 and gas production rate of 2.32 Nm3/kg could be produced. Tar concentration in the fuel gas could be reduced to 108 mg/Nm3 (at the gasifier outlet and 38 mg/Nm3 (after gas conditioning. The cold gas efficiency and carbon conversion rate reached 75% and 78%, respectively. The performance of this gasification system shows considerable potential for implementation in distributed electricity and heat supply projects.

  11. Performance Calculations for a Boundary-Layer-Ingesting Fan Stage from Sparse Measurements

    Science.gov (United States)

    Hirt, Stefanie M.; Wolter, John D.; Arend, David J.; Hearn, Tristan A.; Hardin, Larry W.; Gazzaniga, John A.

    2018-01-01

    A test of the Boundary Layer Ingesting-Inlet / Distortion-Tolerant Fan was completed in NASA Glenn's 8-Foot by 6-Foot supersonic wind tunnel. Inlet and fan performance were measured by surveys using a set of rotating rake arrays upstream and downstream of the fan stage. Surveys were conducted along the 100 percent speed line and a constant exit corrected flow line passing through the aerodynamic design point. These surveys represented only a small fraction of the data collected during the test. For other operating points, data was recorded as snapshots without rotating the rakes which resulted in a sparser set of recorded data. This paper will discuss analysis of these additional, lower measurement density data points to expand our coverage of the fan map. Several techniques will be used to supplement the snapshot data at test conditions where survey data also exists. The supplemented snapshot data will be compared with survey results to assess the quality of the approach. Effective methods will be used to analyze the data set for which only snapshots exist.

  12. Comparison of ethanol production performance in 10 varieties of sweet potato at different growth stages

    Science.gov (United States)

    Jin, Yanling; Fang, Yang; Zhang, Guohua; Zhou, Lingling; Zhao, Hai

    2012-10-01

    The performance in the ethanol production of 10 varieties of sweet potato was evaluated, and the consumption in raw materials, land occupation and fermentation waste residue in producing 1 ton of anhydrous ethanol were investigated. The comparative results between 10 varieties of sweet potato at 3 growth stages indicated that NS 007 and SS 19 were better feedstocks for ethanol production, exhibiting less feedstock consumption (6.19 and 7.59 tons/ton ethanol, respectively), the least land occupation (0.24 and 0.24 ha/ton ethanol, respectively), less fermentation waste residue (0.56 and 0.55 tons/ton ethanol, respectively), the highest level of ethanol output per unit area (4.17 and 4.17 ton/ha, respectively), and a lower viscosity of the fermentation culture (591 and 612 mPa S, respectively). The data above are average data. In most varieties, the ethanol output speed at day 130 was the highest. Therefore, NS 007 and SS 19 could be used for ethanol production and harvested after 130 days of growth from an economic point of view. In addition, the high content of fermentable sugars and low content of fiber in sweet potatoes are criteria for achieving low viscosity in ethanol fermentation cultures.

  13. [Predictive value of Ages & Stages Questionnaires for cognitive performance at early years of schooling].

    Science.gov (United States)

    Schonhaut B, Luisa; Pérez R, Marcela; Castilla F, Ana María; Castro M, Sonia; Salinas A, Patricia; Armijo R, Iván

    2016-10-13

    The Ages and Stages questionnaires (ASQ) has been recently validated in our country for developmental screening. The objective of this study is evaluate the validity of ASQ to predict low cognitive performance in the early years of schooling. Diagnostic test studies conducted on a sample of children of medium-high socioeconomic level were evaluated using ASQ at least once at 8, 18 and/or 30 months old, and later, between 6 and 9 years old, reevaluated using the Wechsler Intelligence Scale for Children-third edition (WISC-III). Each ASQ evaluation was recorded independently. WISC-III was standardized, considering underperformance when the total score were under -1 standard deviation RESULTS: 123 children, corresponding to 174 ASQ assessments (42 of them were 8 months old, 55 were 18 months and 77 were 30 months of age) were included. An area under the ROC curve of 80.7% was obtained, showing higher values at 8 months (98.0%) compared to 18 and 30 months old (78.1 and 79.3%, respectively). Considering different ASQ scoring criteria, a low sensitivity (27.8 to 50.0%), but a high specificity (78.8 to 96.2%) were obtained; the positive predictive value ranged between 21 and 46%, while the negative value was 92.0-93.2%. ASQ has low sensitivity but excellent specificity to predict a low cognitive performance during the first years of schooling, being a good alternative to monitor psychomotor development in children who attend the private sector healthcare in our country. Copyright © 2016 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. Evaluation of performance and microbial community in a two-stage UASB reactor pretreating acrylic fiber manufacturing wastewater.

    Science.gov (United States)

    Li, Jin; Wang, Jun; Luan, Zhaokun; Deng, Yanqin; Chen, Lin

    2011-05-01

    A two-stage UASB reactor was employed to pretreat acrylic fiber manufacturing wastewater. Mesophilic operation (35 ± 0.5°C) was performed with hydraulic retention time (HRT) varied between 28 and 40 h. Mixed liquor suspended solids (MLSS) in the reactor was maintained about 8000 mg/L. The results showed COD and sulfate removal could be kept at 51% and 75%, respectively, when the HRT was no less than 38 h. Sulfate reduction mainly occurred in the acidification-stage reactor while methane production mainly occurred in the methane-stage reactor. The size of granule formed in the acidification-stage reactor ranged between 1 and 5mm while the largest size of granule in the methane-stage reactor ranged from 0.5 to 2mm. Compared to microbial populations in the acidification-stage reactor, the microbial diversity in methane-stage reactor was more abundant. In the acidification-stage reactor, the Syntrophobacter sulfatireducens devoted to both sulfate reduction and acetate production. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. The Variable and Changing Status of Performance Art Relics and Artifacts in Museum Collections

    DEFF Research Database (Denmark)

    Cone, Louise

    2017-01-01

    The status of an artwork in a museum collection is variable and contingent upon factors and parameters that are specific not only to the logic of the museum world but also to factors extrinsic to the museum. In particular older performance art 'relics' are subject to contextual interpretations...... and changes in meaning and status. Some philosophical and sociological theories that address how objects and things are percieved and defined, such as Pierre Bourdieu's theory of Habitus and cultural mapping, the Actor-Network Theory and Thing Theories, will be looked at in an attempt to understand...

  16. [A retrospective study on nutritional status and growth and development of 37 children with chronic kidney disease stage 3 to 5].

    Science.gov (United States)

    Bao, R; Chen, C Y

    2016-09-01

    To retrospectively analyze the nutritional status and growth and development situation of the children with chronic kidney disease stage 3 to 5 when they were diagnosed at the first visit. After searching for the data of all the hospitalized cases during January 2007 to September 2015 in the Department of Nephrology of Children's Hospital Affiliated to the Capital Institute of Pediatrics from the medical record system, data of 37 cases with complete clinical data were collected; all these cases were diagnosed as chronic kidney disease stage 3 to 5 according to the diagnostic criteria.We recorded these children's age, height, weight, body mass index, albumin, blood lipids and acidosis situation when they were first diagnosed, and then, analyzed and summarized their nutritional status and growth and development situation. In these 37 cases, 24 cases were boys and 13 cases were girls; 23 cases (62%) were shorter than the third percentile of age-sex-specific height; 18 cases (49%) exhibited lower weight than the third percentile of age-sex-specific weight; 5 cases (13.5%) showed lower BMI than the third percentile of height-age BMI, and 5 cases (13.5%) had obesity. The level of albumin was (37.0±8.7) g/L, and no statistically significant difference was observed within each stage. In all of these cases, 10 cases were hypoalbuminemia (27%), and the difference of its frequency between stage 3-4 and stage 5 was not statistically significant. Triglyceride was (2.2±1.1) mmol/L. The mean level was higher than the normal range, but with no statistically significant difference within each stage; 21 cases (62%) were diagnosed as hypertriglyceridemia, which were more frequent compared with the occurrence of the hypercholesterolemia (32%), the high low density lipoprotein (26%) and the low high density lipoprotein(12%). And the occurrence of decompensated metabolic acidosis in stage 5 (69%) was significantly higher than that in stage 3-4 (38%) (P=0.036 6, Growth retardation is

  17. The Effects of Solo Status on Women's and Men's Success: The Moderating Role of the Performance Context

    Science.gov (United States)

    Viallon, Marie-Laure; Martinot, Delphine

    2009-01-01

    A considerable body of research has shown that being the only representative of one's gender group (solo status) when performing an activity affects women more than men. The aim of our two experiments was to show that the performance context can moderate the effects of numerical status (majority vs. solo) on performance and that men can also be…

  18. How do mood states change in a multi-stage cycling competition? Comparing high and low performers.

    Science.gov (United States)

    Murgia, Mauro; Forzini, Fabio; Filho, Edson; DI Fronso, Selenia; Sors, Fabrizio; Bertollo, Maurizio; Agostini, Tiziano

    2016-03-01

    Our purpose was to investigate: (1) differences in mood states between high and low performers at the beginning and end of the Girobio 2012 cycling race, and in respect to both actual and perceived performance; (2) whether the participants' mood states predicted the actual and perceived performance. Profile of Mood States (POMS) of 72 elite cyclists were assessed the day prior to the first (T0) and last stage (T1). At the end of the race, we created two rankings, one based on the total time spent to complete the race (actual ranking) and one based on the average of self-evaluations provided at the end of each stage (perceived ranking). We compared high and low performers, considering both rankings, using a general measure of mood; i.e. the total mood disturbance. Total mood disturbance differed among high and low performers. In particular, high performers mood disturbance did not differ between T0 and T1, whereas low performing cyclists showed higher levels of mood disturbance at the end of the race. Furthermore, we found that mood disturbance at T0 did not predict either actual or perceived performance. The cyclists' mood states at the beginning of the race were not reliable predictors of performance throughout the race. High-performing cyclists maintained a more positive mood profile than their low-performing counterparts at the beginning and end of a multi-stage race.

  19. Investigating the performance of directional boundary layer model through staged modeling method

    Science.gov (United States)

    Jeong, Moon-Gyu; Lee, Won-Chan; Yang, Seung-Hune; Jang, Sung-Hoon; Shim, Seong-Bo; Kim, Young-Chang; Suh, Chun-Suk; Choi, Seong-Woon; Kim, Young-Hee

    2011-04-01

    BLM since the feasibility of the BLM has been investigated in many papers[4][5][6]. Instead of fitting the parameters to the wafer critical dimensions (CD) directly, we tried to use the aerial image (AI) from the rigorous simulator with the electromagnetic field (EMF) solver. Usually that kind of method is known as the staged modeling method. To see the advantages of this method we conducted several experiments and observed the results comparing the method of fitting to the wafer CD directly. Through the tests we could observe some remarkable results and confirmed that the staged modeling had better performance in many ways.

  20. Stages of changes for fruit and vegetable intake and their relation to the nutritional status of undergraduate students.

    Science.gov (United States)

    Reis, Lígia Cardoso dos; Correia, Ingrid Chaves; Mizutani, Edna Shibuya

    2014-01-01

    To assess the nutritional and dietetic profile of freshman Nutrition undergraduate students, and its association with stages of changes (Transtheoretical Model) for fruit and vegetable intake. Demographic (age and gender), anthropometric (body mass index and waist circumference) and nutritional (pattern of fruit and vegetable intake) data were obtained. The Transtheoretical Model was used to identify the stages of change for fruit and vegetable intake. Food consumption was assessed with a questionnaire developed by the Ministry of Health. The significance level considered for all statistical tests was 0.05 (pfruit and vegetables intake (29.8%), being the majority (64.9%) of them classified as at the preparation stage to increase the intake of these food groups. Prevalence of adequate fruit and vegetables intake was higher among students at the action/maintenance stages (83.3%) compared to those at the precontemplation/contemplation (18.3%) and at the preparation stages (32.0%). Students at the preparation stage presented the highest medians for body mass index (p=0.004) and waist circumference (p=0.039) compared to those at the precontemplation/contemplation stages. There was no association between fruit and vegetables intake and the presence of overweight or abdominal obesity (p=0.373). This instrument is effective to predict the food intake and, even among aware individuals and ready to change their food behavior, the prevalence of nutritional risk is high.

  1. Performance analysis of spectrum sensing with multiple status changes in primary user traffic

    KAUST Repository

    Tang, Liang

    2012-06-01

    In this letter, the impact of primary user traffic with multiple status changes on the spectrum sensing performance is analyzed. Closed-form expressions for the probabilities of false alarm and detection are derived. Numerical results show that the multiple status changes of the primary user cause considerable degradation in the sensing performance. This degradation depends on the number of changes, the primary user traffic model, the primary user traffic intensity and the signal-to-noise ratio of the received signal. Numerical results also show that the amount of degradation decreases when the number of changes increases, and converges to a minimum sensing performance due to the limited sensing period and primary holding time. © 2012 IEEE.

  2. Adolescent Weight Status and Self-Reported School Performance in South Korea

    Directory of Open Access Journals (Sweden)

    Young Kyung Do

    2011-01-01

    Full Text Available Using a nationally representative sample of 142 783 middle school (13–15 years old and high school (16–18 years old students in South Korea, this study examined whether (1 overweight and obesity are more likely to be associated with lower self-reported school performance; (2 overweight and obese students are more likely to enrol in a vocational high school as opposed to a general high school; (3 the association between obesity and poorer self-reported school performance is mediated through body image stress and health status. We found that excess weight was negatively associated with self-reported school performance among middle and general high school students, and that obese students had a higher probability of being enrolled in a vocational over a general high school. We did not find strong evidence on the mediating role of body image stress and health status.

  3. Examination of the Impact of Health Status on Economic Performance in Hungary

    Directory of Open Access Journals (Sweden)

    Bakos Izabella Mária

    2017-11-01

    Full Text Available For a long time it has been a well-known and proven fact that economic growth of a country contributes to improvement of the health status of population. There is at the same time another type of opposite relationship starting from health status and pointing to the performance of economy. In our study, besides giving a general presentation of the health situation in Hungary, we examined the direction and strength of the relations between health and economic indicators and the inequalities that can be identified between the different regions with help of statistical methods. Another objective of the study was to examine the factors influencing mortality, and to develop a multiple linear regression equation to estimate the degree of mortality at a confidence interval of 95%. The results could provide a good basis to determine the intervention points necessary to alleviate and improve the economic burden of bad health status and diseases.

  4. Life stages of an aphid living under similar thermal conditions differ in thermal performance.

    Science.gov (United States)

    Zhao, Fei; Hoffmann, Ary A; Xing, Kun; Ma, Chun-Sen

    2017-05-01

    Heat responses can vary ontogenetically in many insects with complex life cycles, reflecting differences in thermal environments they experience. Such variation has rarely been considered in insects that develop incrementally and experience common microclimates across stages. To test if there is a low level of ontogenetic variation for heat responses in one such species, the English grain aphid Sitobion avenae, basal tolerance [upper lethal temperature (ULT 50 ) and maximum critical temperature (CT max )], hardening capacity (CT max ) and hardening costs (adult longevity and fecundity) were measured across five stages (1st, 2nd, 3rd and 4th-instar nymphs and newly moulted adults). We found large tolerance differences among stages of this global pest species, and a tendency for the stage with lower heat tolerance to show a stronger hardening response. There were also substantial reproductive costs of hardening responses, with the level of stress experienced, and not the proximity of the exposed stage to the reproductive adult stage, influencing the magnitude of this cost. Hence hardening in this aphid may counter inherently low tolerance levels of some life stages but at a cost to adult longevity and fecundity. Our findings highlight the significance of ontogenetic variation in predicting responses of a species to climate change, even in species without a complex life cycle. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Relationship Between Preoperative Sarcopenia Status and Immuno-nutritional Parameters in Patients with Early-stage Non-small Cell Lung Cancer.

    Science.gov (United States)

    Shoji, Fumihiro; Matsubara, Taichi; Kozuma, Yuka; Haratake, Naoki; Akamine, Takaki; Takamori, Shinkichi; Katsura, Masakazu; Toyokawa, Gouji; Okamoto, Tatsuro; Maehara, Yoshihiko

    2017-12-01

    Although the skeletal muscle in the region of the third lumbar vertebra (L3) is generally assessed in order to judge sarcopenia, not every patient with non-small cell lung cancer (NSCLC) undergoes computed tomography including the L3 region. We hypothesized that immuno-nutritional parameters could predict the existence of sarcopenia in patients with NSCLC. The aim of this study was to retrospectively investigate the correlation between preoperative sarcopenia and immuno-nutritional parameters in patients with early-stage NSCLC. We selected 147 of patients with pathological stage I NSCLC who underwent preoperative measurement of immuno-nutritional parameters and CT including the L3 region. Preoperative sarcopenia was significantly associated with female gender (p=0.0003) and poor prognosis (p=0.0322). In Kaplan-Meier analysis of overall survival (OS) by preoperative sarcopenia status, the sarcopenic group had significantly shorter OS than the non-sarcopenic group (5-year OS: 87.27% vs. 77.37%, p=0.0131, log-rank test). In multivariate analysis, the preoperative sarcopenia status (hazard ratio=5.138; 95% confidence interval=2.305-11.676; pnutritional status score (p=0.0071) and Geriatric Nutritional Risk Index (GNRI) (p<0.0001). Spearman's correlation test showed good significant correlation between preoperative sarcopenia status and GNRI (r=0.348, p<0.0001). The preoperative GNRI is a simple and useful predictor for existence of preoperative sarcopenia which was associated with poor outcome in patients with early-stage NSCLC. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  6. Thermal Performance Analysis of Staging Effect of Solar Thermal Absorber with Cross Design

    International Nuclear Information System (INIS)

    Amir Abdul Razak; Zafri Azran Abdul Majid; Mohd Hafidz Ruslan; Kamaruzzaman Sopian

    2015-01-01

    The type and shape of solar thermal absorber materials will impact on the operating temperature and thermal energy storage effect of a solar air thermal collector. For a standard flat-plate design, energy gain can be increased by expanding the thermal absorber area along the collector plane, subject to area limitation. This paper focuses on the staging effect of a metal hollow square rod absorber of aluminium, stainless steel, and a combination of the two with a cross design, for the heat gain and temperature characteristics of a solar air collector. Experiments were carried out with three cross design set-ups, with 30 minutes of heating and cooling, phase, respectively, under 485 W/ m 2 solar irradiance value, and at a constant air speed at 0.38 m/ s. One set aluminium set-up delivered the highest output temperature of 41.8 degree Celsius, followed by two-sets aluminium and one aluminium set + one stainless steel set at 39.3 and 38.2 degree Celsius, respectively. The lowest peak temperature is recorded on three sets of the aluminium absorber at 35 degree Celsius. The bi-metallic set-up performed better than the two aluminium set-up where each set-up obtained a temperature drop against heat gain gradient value of -0.4186 degree Celsius/ W and -0.4917 degree Celsius/ W, respectively. Results concluded that by increasing the number of sets, the volume and surface areas of the absorber material are also increased, and lead to a decrease in peak temperature output for each increase of sets. (author)

  7. The Association of Self-reported Sleep, Weight Status and Academic Performance in Fifth Grade Students

    Science.gov (United States)

    McNally, Janise; Plog, Amy; Siegfried, Scott; Hill, James O.

    2012-01-01

    BACKGROUND To improve support and justification for health promotion efforts in schools, it is helpful to understand how students’ health behaviors affect academic performance. METHODS Fifth grade students completed an online school administered health survey with questions regarding their eating behavior, physical activity, academic performance, and sleep patterns. Differences in health behaviors were examined by sex, self-reported weight status, and sufficient (≥ 9 hours) versus insufficient sleep. Logistic regression was used to determine the relationship between academic performance and the health behaviors. RESULTS One-third of the sample did not get the recommended amount of physical activity and more than half of the students watched TV ≥ 2 hours/day. Self-reported overweight status was related to lower self-reported academic performance, fewer lunch and breakfast occasions, less physical activity, not meeting the recommendations for vegetable and soda consumption as well as hours of TV watching. Sufficient sleep (≥ 9 hours/night) was associated with better grades, meeting the recommended hours of daily TV watching and video game playing, being more physically active and increased breakfast and lunch frequency. Percentage of serving free/reduced lunch, soda consumption, breakfast frequency, amount of physical activity, and TV watching were associated with academic performance. CONCLUSION More positive health behaviors generally were associated with better academic performance. Promoting healthy behaviors in schools might improve not only students’ health academic performance as well. PMID:23331266

  8. Cognitive Performance and Iron Status are Negatively Associated with Hookworm Infection in Cambodian Schoolchildren.

    Science.gov (United States)

    Kuong, Khov; Fiorentino, Marion; Perignon, Marlene; Chamnan, Chhoun; Berger, Jacques; Sinuon, Muth; Molyden, Vann; Burja, Kurt; Parker, Megan; Ly, Sou Chheng; Friis, Henrik; Roos, Nanna; Wieringa, Frank T

    2016-10-05

    Soil-transmitted helminth (STH) infection has been associated with lower cognitive performance of schoolchildren. To identify pathways through which STH infection might affect school performance, baseline data from a large rice-fortification trial in Cambodian schoolchildren were used to investigate associations between STH infection, micronutrient status, anemia, and cognitive performance. Complete data on anthropometry, cognitive performance, and micronutrient status were available for 1,760 schoolchildren, 6-16 years of age. STH infection was identified using Kato-Katz, whereas cognitive performance was assessed using Raven's Colored Progressive Matrices (RCPM), block design, and picture completion. STH infection was found in 18% of the children; almost exclusively hookwork infection. After adjusting for age and gender, raw cognitive test scores were significantly lower in hookworm-infected children (-0.65; -0.78; -2.03 points for picture completion, RCPM, and block design, respectively; P cognitive performance, an effect most likely mediated through lower body iron. Interventions that are more effective against hookworm infection are needed to contribute to better health and improvement of cognitive performance. © The American Society of Tropical Medicine and Hygiene.

  9. ATLAS Physics Objects Status and Performance at 13 TeV

    CERN Document Server

    Riu, Imma; The ATLAS collaboration

    2015-01-01

    Important for physics analyses is the understanding and commissioning of physics objects. A first look at the 13 TeV data has proved a reasonably good Monte Carlo modelling of the objects and they have been used for first physics measurements and searches beyond the Standard Model. This talk is to be given at the Top Workshop and provides an overview of the status and performance of the physics objects with the early 13 TeV data taken in summer 2015.

  10. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs......, and something quite different is undergoing. This paper intends to discuss three examples of performances in which the composer’s appearance on stage was an important part of the piece, - both when it came to the role as a performer and as an individual person – as representer and presenter. The paper intends...... to rise the following questions: What happens to the status of the author, when he suddenly (re-)appears on stage? How is this appearance to be understood in both a contemporary and historical context: Is it the musical virtuous appearing again, are we witnessing musical works turning...

  11. CDC's Prevention Status Reports: Monitoring the Status of Public Health Policies and Practices for Improved Performance and Accountability.

    Science.gov (United States)

    Young, Andrea C; Lowry, Garry; Mumford, Karen; Graaf, Christine

    Increasing the adoption and implementation of evidence-based policies and practices is a key strategy for improving public health. Although there is widespread agreement about the importance of implementing evidence-based public health policies and practices, there are gaps between what has been shown to be effective and what is implemented at the state level. The Centers for Disease Control and Prevention (CDC) developed the Prevention Status Reports (PSRs), a performance measurement system, to highlight evidence-based public health policies and practices and catalyze state performance and quality improvement efforts across the nation. CDC selected a set of 10 topics representing some of the most important public health challenges in the nation. Stakeholders, including state health departments and other partners, helped conceptualize the PSRs and informed the development of the PSR framework, which provides an organizational structure for the system. CDC subject matter experts developed criteria for selecting policies and practices, indicators for each policy and practice, and a criteria-based rating system for each indicator. The PSRs were developed for all 50 states and the District of Columbia. The PSRs were developed and serve as a performance measurement system for monitoring the adoption, reach, and implementation fidelity of evidence-based public health policies and practices nationwide. The PSRs include 33 policy and practice indicators across the 10 health topics. They use a simple 3-level rating system-green, yellow, and red-to report the extent to which each state (and the District of Columbia) has implemented the policy or practice in accordance with supporting evidence or expert recommendations. Results from aggregate analyses show positive change or improvement. The PSRs are a unique part of CDC's work to improve the performance and accountability of the public health system, serving as both a monitoring tool and a call to action to improve health

  12. Effect of yoghurt serum powder dietary supplementation on growth performance and antioxidant status in fattening lambs

    Directory of Open Access Journals (Sweden)

    Panagiotis E Simitzis

    2015-01-01

    Full Text Available Large quantities of serum are produced during the strained yoghurt manufacturing process, which is the predominant type of yoghurt in Greece. However, the exploitation of this by-product as an alternative source of energy, protein and mineral elements in animal diets has not yet been examined. Therefore, this experiment was conducted to determine the effects of dietary yoghurt serum supplementation on growth performance and antioxidant status in sheep. Fourty eight male 2 months old lambs of Chios breed were randomly assigned to three experimental groups; control group was fed with a commercial basal diet, whereas the other two groups consumed the same diet, with the only difference that concentrated feed was uniformly supplemented with two levels of yoghurt serum powder (YS1: 25 g/kg feed or YS2: 50 g/kg feed. Lambs were weighed in a weekly basis from the beginning until the end of the experiment and blood samples were collected to measure antioxidant status. No significant effect of yoghurt serum powder on growth performance of fattening lambs was demonstrated, even after 28 days of dietary supplementation (P>0.05. At the same time, malondialdehyde (MDA levels in blood plasma were not significantly different among the experimental groups (P>0.05 and no incidents of lambs with diarrhea were recorded. It can be concluded that yoghurt serum powder appears as a promising alternative of the cereals in the diets of fattening lambs, since no negative effects on growth performance and health status were observed.

  13. Food provisioning and parental status in songbirds: can occupancy models be used to estimate nesting performance?

    Directory of Open Access Journals (Sweden)

    Aude Catherine Corbani

    Full Text Available Indirect methods to estimate parental status, such as the observation of parental provisioning, have been problematic due to potential biases associated with imperfect detection. We developed a method to evaluate parental status based on a novel combination of parental provisioning observations and hierarchical modeling. In the summers of 2009 to 2011, we surveyed 393 sites, each on three to four consecutive days at Forêt Montmorency, Québec, Canada. We assessed parental status of 2331 adult songbirds based on parental food provisioning. To account for imperfect detection of parental status, we applied MacKenzie et al.'s (2002 two-state hierarchical model to obtain unbiased estimates of the proportion of sites with successfully nesting birds, and the proportion of adults with offspring. To obtain an independent evaluation of detection probability, we monitored 16 active nests in 2010 and conducted parental provisioning observations away from them. The probability of detecting food provisioning was 0.31 when using nest monitoring, a value within the 0.11 to 0.38 range that was estimated by two-state models. The proportion of adults or sites with broods approached 0.90 and varied depending on date during the sampling season and year, exemplifying the role of eastern boreal forests as highly productive nesting grounds for songbirds. This study offers a simple and effective sampling design for studying avian reproductive performance that could be implemented in national surveys such as breeding bird atlases.

  14. Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancers

    NARCIS (Netherlands)

    de Cuba, E. M. V.; Snaebjornsson, P.; Heideman, D. A. M.; van Grieken, N. C. T.; Bosch, L. J. W.; Fijneman, R. J. A.; Belt, E.; Bril, H.; Stockmann, H. B. A. C.; Hooijberg, E.; Punt, C. J. A.; Koopman, M.; Nagtegaal, I. D.; Coupé, V. H. M.; Carvalho, B.; Meijer, G. A.

    2016-01-01

    Microsatellite instability (MSI) has been associated with favourable survival in early stage colorectal cancer (CRC) compared to microsatellite stable (MSS) CRC. The BRAF V600E mutation has been associated with worse survival in MSS CRC. This mutation occurs in 40% of MSI CRC and it is unclear

  15. Performance and microbial community structures of hydrolysis acidification process treating azo and anthraquinone dyes in different stages.

    Science.gov (United States)

    Liu, Na; Xie, Xuehui; Yang, Bo; Zhang, Qingyun; Yu, Chengzhi; Zheng, Xiulin; Xu, Leyi; Li, Ran; Liu, Jianshe

    2017-01-01

    In this study, performance of hydrolysis acidification process treating simulated dyeing wastewater containing azo and anthraquinone dyes in different stages was investigated. The decolorization ratio, COD Cr removal ratio, BOD 5 /COD Cr value, and volatile fatty acids (VFAs) production were almost better in stage 1 than that in stage 2. Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry (GC-MS) confirmed the biodegradation of Reactive Black 5 (RB5) and Remazol Brilliant Blue R (RBBR) in hydrolysis acidification process. Polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) analyses revealed that significant difference of microbial community structures existed in stage 1 and 2. The dominant species in stage 1 was related to Bacteroidetes group, while the dominant species in stage 2 was related to Bacteroidetes and Firmicutes groups. From the results, it could be speculated that different dyes' structures might have significant influence on the existence and function of different bacterial species, which might supply information for bacteria screening and acclimation in the treatment of actual dyeing wastewater.

  16. Effect of First-Stage Blade Design on Performance of Mark 25 Torpedo Power Plant

    Science.gov (United States)

    Schum, Harold J.; Hoyt, Jack W.

    1948-01-01

    The effect of rotor-blade length, inlet angle, and shrouding was investigated with four different nozzles in a single-stage modification of the Mark 25 aerial-torpedo power plant. The results obtained with the five special rotor configurations are compared with those of the standard first-stage rotor with each nozzle. Each nozzle-rotor combination was operated at nominal pressure ratios of 8, 15 (design), and 20 over a range of speeds from 6000 rpm to the design speed of 18,000 rpm. Inlet temperature and pressure conditions of 1OOOo F and 95 pounds per square inch gage, respectively, were maintained constant for all runs.

  17. Performance capacity, fighting tactics and the evolution of life-stage male morphs in the green anole lizard (Anolis carolinensis).

    OpenAIRE

    Lailvaux, Simon P.; Herrel, Anthony; Vanhooydonck, Bieke; Meyers, Jay J.; Irschick, Duncan J.

    2004-01-01

    The evolution of alternative male phenotypes is probably driven by male-male competition for access to reproductive females, but few studies have examined whether whole-organism performance capacities differ between male morphs, and if so whether any such differences affect fighting ability. We show how ontogenetic changes in performance and morphology have given rise to two distinct life-stage male morphs exhibiting different fighting tactics within the green anole lizard (Anolis carolinensi...

  18. Performance analysis of a single stage four bed metal hydride cooling system, part A: Influence of mass recovery

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Kevin; Prakash Maiya, M.; Srinivasa Murthy, S. [Refrigeration and Air-conditioning Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Madras, 600036, Chennai (India)

    2003-01-01

    The concept of mass recovery in metal hydride systems is studied with a single stage multi-bed cooling system as example. Mass recovery results in variation of bed temperatures due to removal or addition of heat of desorption or absorption respectively. Coefficient of performance and cold output increase while required heat input decreases for the mass recovery cycle. Thus mass recovery between hydride reactors is found to improve system performance compared to that of a basic system. (authors)

  19. Breast cancer stage variation and survival in association with insurance status and sociodemographic factors in US women 18 to 64 years old.

    Science.gov (United States)

    Hsu, Christine D; Wang, Xiaoyan; Habif, David V; Ma, Cynthia X; Johnson, Kimberly J

    2017-08-15

    Few population-based studies have examined the association between health insurance status and breast cancer stage at diagnosis and survival. The degree to which sociodemographic characteristics explain this association is also unclear. This study examined associations between insurance status and sociodemographic characteristics and stage at diagnosis and survival. Using the Surveillance, Epidemiology, and End Results 18 registries database, we identified 52,048 women aged 18 to 64 years who were diagnosed with breast cancer in 2007 and 2008. Associations between insurance status and sociodemographic variables and stage at diagnosis and survival were examined with logistic and Cox proportional hazards regression models to calculate adjusted odds ratios (ORs), hazard ratios (HRs), and associated confidence intervals (CIs). The odds of a later stage breast cancer diagnosis were increased in women with Medicaid (OR, 2.36; 95% CI, 2.19-2.55) and no insurance (OR, 2.64; 95% CI, 2.29-3.04) versus private insurance, in women who had reported black race (OR, 1.18; 95% CI, 1.09-1.28) versus white race, in women who were unmarried (OR, 1.25; 95% CI, 1.18-1.33) versus married at diagnosis, and in women who were 18 to 39 years old (OR, 1.29; 95% CI, 1.18-1.41) versus 40 to 64 years old at diagnosis. The hazard of breast cancer death was increased in association with Medicaid (HR, 1.40; 95% CI, 1.30-1.51) and no insurance (HR, 1.61; 95% CI, 1.41-1.84) versus private insurance, with reported black race (HR, 1.39; 95% CI, 1.29-1.50) versus reported white race, and with being unmarried (HR, 1.19; 95% CI, 1.12-1.27) versus being married. Insurance status at diagnosis and sociodemographic factors are associated with breast cancer mortality. Factors underlying these associations warrant further study. Cancer 2017;123:3125-31. © 2017 American Cancer Society. © 2017 American Cancer Society.

  20. Endoscopic ultrasound guided biopsy performed routinely in lung cancer staging spares futile thoracotomies

    DEFF Research Database (Denmark)

    Larsen, Soeren S; Vilmann, Peter; Krasnik, Mark

    2005-01-01

    BACKGROUND: Up to 45% of operations with curative intent for non-small-cell lung cancer (NSCLC) can be regarded as futile, apparently because the stage of the disease is more advanced than expected preoperatively. During the past decade several studies have evaluated the usefulness of endoscopic ...

  1. Performance Enhancement in L-Band Edfa Through Dual Stage Technique

    Directory of Open Access Journals (Sweden)

    S. W. Harun and H. Ahmad

    2012-10-01

    Full Text Available An experiment on gain enhancement in the long wavelength band erbium doped fiber amplifier (L-band EDFA is demonstrated. It uses a dual stage technique with dual forward pumping scheme. Compared to a conventional single stage amplifier, the small signal gain for 1580nm signal can be improved by 5.5dB without paying much noise figure penalty. The corresponding noise figure penalty was 0.3dB due to the insertion loss of the optical isolator. The optimum pump power ratio for the first pump is experimentally determined to be 33%. The maximum gain improvement of 8.3dB was obtained at a signal wavelength of 1568nm while signal and total pump powers were fixed at -30dBm and 92mW, respectively. The employment of dual stage amplifier system seems to play an important role in the development of practical L-band EDFA from the perspective of economical usage of pump power.Key Words:  erbium doped fibre; optical amplifier; L-band EDFA; dual stage EDFA; amplified spontaneous emission

  2. "Life Stage-Specific" Variations in Performance in Response to Age Stereotypes

    Science.gov (United States)

    Hehman, Jessica A.; Bugental, Daphne Blunt

    2013-01-01

    In a test of life stage-specific responses to age-based stigma, older (n = 54, ages 62-92) and younger (n = 81, ages 17-22) adults were told that a task (Weschler Adult Intelligence Scale-III block design) required either (a) speed/contemporary knowledge (YA; "youth advantage") or (b) life experience/wisdom (OA; "age…

  3. Long-term changes of activity of cortical neurons after status epilepticus induced at early developmental stages in rats

    Czech Academy of Sciences Publication Activity Database

    Doczi, J.; Bernášková, Klára; Kubová, Hana; Détari, L.; Világi, I.; Druga, Rastislav; Mareš, Pavel

    2003-01-01

    Roč. 352, č. 2 (2003), s. 125-128 ISSN 0304-3940 R&D Projects: GA ČR GA309/00/1643; GA ČR GA309/03/0770 Institutional research plan: CEZ:AV0Z5011922 Keywords : cerebral cortex * unit activity * consequences of status epilepticus Subject RIV: FH - Neurology Impact factor: 1.967, year: 2003

  4. Thrombocytosis portends adverse prognostic significance in patients with stage II colorectal carcinoma [v2; ref status: indexed, http://f1000r.es/4k6

    Directory of Open Access Journals (Sweden)

    Tianhua Guo

    2014-10-01

    Full Text Available Thrombocytosis portends adverse prognostic significance in many types of cancers including ovarian and lung carcinoma. In this study, we determined the prevalence and prognostic significance of thrombocytosis (defined as platelet count in excess of 400 × 103/μl in patients with colorectal cancer. We performed a retrospective analysis of 310 consecutive patients diagnosed at our Institution between 2004 and 2013. The patients (48.7% male and 51.3% female had a mean age of 69.9 years (+/- 12.7 years at diagnosis. Thrombocytosis was found in a total of 25 patients, with a higher incidence in those with stage III and IV disease (14.4% of patients. Although the mean platelet count increased with the depth of tumor invasion (pT, its values remained within normal limits in the whole patient cohort. No patient with stage I cancer (n=57 had elevated platelet count at diagnosis. By contrast, five of the 78 patients (6.4% with stage II cancer showed thrombocytosis, and four of these patients showed early recurrence and/or metastatic disease, resulting in shortened survival (they died within one year after surgery. The incidence of thrombocytosis increased to 12.2% and 20.6%, respectively, in patients with stage III and IV disease. The overall survival rate of patients with thrombocytosis was lower than those without thrombocytosis in the stage II and III disease groups, but this difference disappeared in patients with stage IV cancer who did poorly regardless of their platelet count. We concluded that thrombocytosis at diagnosis indicates adverse clinical outcome in colorectal cancer patients with stage II or III disease. This observation is especially intriguing in stage II patients because the clinical management of these patients is controversial. If our data are confirmed in larger studies, stage II colon cancer patients with thrombocytosis may be considered for adjuvant chemotherapy.

  5. Hospital nurse job attitudes and performance: the impact of employment status.

    Science.gov (United States)

    Chu, Cheng-I; Hsu, Yao-Feng

    2011-03-01

    According to the 2007 Taiwan Labor Front Human Resources Report, as much as 47.6% of nurses at some public hospitals were contracted rather than full time. Furthermore, turnover rates for contract nurses were found to be as high as five to eight times of those for full-time nurses. Because high turnover rates are likely to induce negative impacts on the stability of care provided in the absence of staffing continuity, the association between nursing employment arrangement and nursing care quality is attracting greater attention. This study was designed to investigate the work status of contract versus full-time nurses at a public hospital in Taiwan and to examine the impact of such on work-related attitudes, organizational citizenship behavior, and job performance. Samples were recruited from a public hospital in Taiwan. In addition to self-rated items, researchers used supervisor-rated structured questionnaires for job performance to attenuate the possible effect of common method bias. The study investigated the impact of hospital nurse employment status on work-related attitudes, organizational citizenship behavior, and job performance using a regression model that included the critical work-related attitudes variables of job satisfaction and organizational commitment. Study findings included the following: (a) organizational commitment, job satisfaction, organizational citizenship behavior, and job performance correlate positively with one another. (b) No significant difference between contract and full-time nurses was found in terms of organizational commitment, job satisfaction, organizational citizenship behavior, and self-rated job performance. However, when rated by supervisors, reported job performance levels for full-time nurses were significantly higher than those of contract nurses. (c) Organizational citizenship behavior exhibited a mediating effect between job satisfaction, organizational commitment, and job performance. In this study, supervisors

  6. Effects of nutritional status on academic performance of Malaysian primary school children.

    Science.gov (United States)

    Zaini, M Z Anuar; Lim, C T; Low, W Y; Harun, F

    2005-01-01

    Numerous factors are known to affect the academic performance of students. These include prenatal conditions, birth conditions, postnatal events, nutritional, socio-economic factors and environmental factors. This paper examines the nutritional status and its relationship with academic performance of 9-10 years old primary school children recruited randomly in Selangor, Malaysia. A standard self-administered questionnaire was utilized to obtain pertinent information and a face-to-face interview was also conducted with the parents. Results of the academic performances were extracted from the students' report cards. The intellectual performance was assessed using Raven's Coloured Progressive Matrices. Physical examination was also conducted on these students by doctors. Overall 1,405 students and 1,317 parents responded to the survey. Of these 83.6% were Malays, 11.6% Indians, and 4.2% Chinese. The majority of them (82.9%) were from urban areas. The female: male ratio was 51:49; mean age was 9.71 years. The mean height and weight were 32.3 kg and 135.2 cm respectively. Their mean BMI was 17.42 kg/cm2, with 0.9% underweight, 76.3% normal BMI, 16.3% overweight, and 6.3% obese. Academic performance was significantly correlated with breast feeding, income and educational level of their parents, BMI, and whether they have been taking breakfast. There was a weak correlation between presence of anaemia and intellectual performance. Improving the socio-economic status of the parents will lend a helping hand in the academic performance of the students. Since breast feeding is associated with better academic and intellectual performance it must be emphasized, particularly to expectant mothers in the antenatal clinics.

  7. Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients.

    Science.gov (United States)

    Bae, Susie; Wong, Hui-Li; Tie, Jeanne; Desai, Jayesh; Field, Kathryn; Kosmider, Suzanne; Fourlanos, Spiros; Jones, Ian; Skinner, Iain; Gibbs, Peter

    2015-01-01

    Diabetes is a risk factor for colorectal cancer and several reports suggest worse cancer-specific outcomes in diabetes patients. Recent studies in multiple tumour types indicate metformin may positively impact on cancer-specific and overall survival. A population-based series of stage II colorectal cancer patients treated and followed from 2000 to 2013 were analysed for baseline characteristics, treatment, and outcomes. 1116 patients with stage II colon cancer were identified, 55.5% were male and median age was 70.9 years (range 20.5-101.2). The diabetes patients (21.6%, n = 241) were older than nondiabetes patients (median 74.0 versus 69.6, p = 0.0001). There was no impact of diabetes on cancer presentation or pathology. Diabetes patients were less likely to receive adjuvant treatment (13.7 versus 24.8%, p = 0.002) but were equally likely to complete treatment (69.7 versus 67.7%, p = 1.00). Diabetes did not significantly impact cancer recurrence (HR = 1.07, 95% CI 0.71-1.63) or overall survival (HR = 1.23, 95% CI 0.88-1.72), adjusted for age. Diabetes medication did not impact cancer recurrence or survival. Cancer presentation and outcomes in diabetes patients are comparable to those of nondiabetes patients in those with stage II colon cancer. The effect of metformin merits further evaluation in patients with colon cancer.

  8. HEALTH INDICATORS IN SCHOOL: ASSESSMENT OF NUTRITIONAL STATUS AND MOTOR PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Andressa Ribeiro Contreira

    2013-11-01

    Full Text Available Objective: This study aimed to investigate the relationship among motor performance and nutritional status in students. Methods: Attended by 27 adolescents of both sexes, aged between 11-13 years (average 11.74 ± 0.70 years from a private school in Florianópolis/SC. The motor performance was assessed using the MABC-2. For assess the nutritional status was used the BMI calculus. Results: Among 27 participants, 6 had a risk / indicative of motor difficulties and 9 had overweight. The vast majority of participants had adequate height for age. There was negative significant statistically correlation, but moderate, among BMI and total performance in the MABC-2, indicating that as higher the BMI, worse is the motor performance. Conclusion: Based on these results and the literature, it is suggested that in addition to the identification of children with overweight and motor difficulties, programs targeted physical activity and motor interventions are implemented, especially in the school environment, aiming to maintain the health conditions.

  9. Parasympathetic nervous activity mirrors recovery status in weightlifting performance after training.

    Science.gov (United States)

    Chen, Jui-Lien; Yeh, Ding-Peng; Lee, Jo-Ping; Chen, Chung-Yu; Huang, Chih-Yang; Lee, Shin-Da; Chen, Chiu-Chou; Kuo, Terry B J; Kao, Chung-Lan; Kuo, Chia-Hua

    2011-06-01

    Heart rate variability (HRV) and parasympathetic power are closely related to the well-being and health status in humans. The main goal of the study was to determine whether these measures can reflect recovery status after weight training. After a 10-day detraining period, 7 weightlifters were challenged with a 2-hour weight training which elicited approximately fourfold increases in circulating muscle creatine kinase level and protracted pain feeling (p Weightlifting performance was then evaluated 3, 24, 48, and 72 hours after training to determine the degree of recovery from fatigue. Heart rate variability, circulating dehydroepiandrostendione sulfate (DHEA-S), and muscle damage markers were measured before each performance test. An electrocardiogram was recorded for 5 minutes continuously at rest in seated positions. After training, weightlifting performance of the subjects decreased below baseline in paralleled with suppressed parasympathetic power (high-frequency [HF] HRV), whereas sympathetic power (normalized low-frequency HRV) was slightly elevated at 3 hours of recovery (p weightlifting performances and parasympathetic power returned to baseline values in 24 hours and further increased above baseline during 48-72 hours of recovery in a similar fashion (p training and remained higher than baseline values for the 72-hour recovery period (p weightlifters after training.

  10. Neuropsychological performance in patients with schizophrenia and controls as a function of cigarette smoking status

    Science.gov (United States)

    Wing, Victoria C.; Bacher, Ingrid; Sacco, Kristi A.; George, Tony P.

    2011-01-01

    Schizophrenia is associated with many neurocognitive deficits, some of which are improved by nicotine and cigarette smoking. To better understand the relationship between smoking and cognitive function in schizophrenia, cross-sectional assessment of neuropsychological performance as a function of smoking status (smoker or non-smoker) and smoking history (current, former or never-smoker) in clinically-stable outpatients with schizophrenia and controls was evaluated. Subjects (N=140) were divided into subgroups on the basis of self-report and biochemical verification of smoking history. Current smokers with schizophrenia (n=38), former smokers with schizophrenia (n=17), never-smokers with schizophrenia (n=12), control smokers (n=31), control former smokers (n=16), and control never-smokers (n=26) were administered a comprehensive neuropsychological battery. Smokers were studied under non-deprivation conditions. Comparison of neuropsychological performance in schizophrenia and control subjects revealed significant main effects of diagnosis. Analysis of the data as a function of smoking history demonstrated that never-smokers with schizophrenia performed the poorest on measures of sustained attention, processing speed and response inhibition, when compared to the other schizophrenia subgroups. Cigarette smoking did not alter neuropsychological performance in controls. Our findings suggest that smoking status and history differentially alters neuropsychological outcomes in schizophrenia compared to non-psychiatric controls, and that never-smokers may present with more severe neurocognitive impairments. PMID:21669462

  11. Insights into Sexism: Male Status and Performance Moderates Female-Directed Hostile and Amicable Behaviour.

    Science.gov (United States)

    Kasumovic, Michael M; Kuznekoff, Jeffrey H

    2015-01-01

    Gender inequality and sexist behaviour is prevalent in almost all workplaces and rampant in online environments. Although there is much research dedicated to understanding sexist behaviour, we have almost no insight into what triggers this behaviour and the individuals that initiate it. Although social constructionist theory argues that sexism is a response towards women entering a male dominated arena, this perspective doesn't explain why only a subset of males behave in this way. We argue that a clearer understanding of sexist behaviour can be gained through an evolutionary perspective that considers evolved differences in intra-sexual competition. We hypothesised that female-initiated disruption of a male hierarchy incites hostile behaviour from poor performing males who stand to lose the most status. To test this hypothesis, we used an online first-person shooter video game that removes signals of dominance but provides information on gender, individual performance, and skill. We show that lower-skilled players were more hostile towards a female-voiced teammate, especially when performing poorly. In contrast, lower-skilled players behaved submissively towards a male-voiced player in the identical scenario. This difference in gender-directed behaviour became more extreme with poorer focal-player performance. We suggest that low-status males increase female-directed hostility to minimize the loss of status as a consequence of hierarchical reconfiguration resulting from the entrance of a woman into the competitive arena. Higher-skilled players, in contrast, were more positive towards a female relative to a male teammate. As higher-skilled players have less to fear from hierarchical reorganization, we argue that these males behave more positively in an attempt to support and garner a female player's attention. Our results provide the clearest picture of inter-sexual competition to date, highlighting the importance of considering an evolutionary perspective when

  12. Insights into Sexism: Male Status and Performance Moderates Female-Directed Hostile and Amicable Behaviour.

    Directory of Open Access Journals (Sweden)

    Michael M Kasumovic

    Full Text Available Gender inequality and sexist behaviour is prevalent in almost all workplaces and rampant in online environments. Although there is much research dedicated to understanding sexist behaviour, we have almost no insight into what triggers this behaviour and the individuals that initiate it. Although social constructionist theory argues that sexism is a response towards women entering a male dominated arena, this perspective doesn't explain why only a subset of males behave in this way. We argue that a clearer understanding of sexist behaviour can be gained through an evolutionary perspective that considers evolved differences in intra-sexual competition. We hypothesised that female-initiated disruption of a male hierarchy incites hostile behaviour from poor performing males who stand to lose the most status. To test this hypothesis, we used an online first-person shooter video game that removes signals of dominance but provides information on gender, individual performance, and skill. We show that lower-skilled players were more hostile towards a female-voiced teammate, especially when performing poorly. In contrast, lower-skilled players behaved submissively towards a male-voiced player in the identical scenario. This difference in gender-directed behaviour became more extreme with poorer focal-player performance. We suggest that low-status males increase female-directed hostility to minimize the loss of status as a consequence of hierarchical reconfiguration resulting from the entrance of a woman into the competitive arena. Higher-skilled players, in contrast, were more positive towards a female relative to a male teammate. As higher-skilled players have less to fear from hierarchical reorganization, we argue that these males behave more positively in an attempt to support and garner a female player's attention. Our results provide the clearest picture of inter-sexual competition to date, highlighting the importance of considering an evolutionary

  13. Effects of Stator Shroud Injection on the Aerodynamic Performance of a Single-Stage Transonic Axial Compressor

    International Nuclear Information System (INIS)

    Dinh, Cong-Truong; Ma, Sang-Bum; Kim, Kwang Yong

    2017-01-01

    In this study, stator shroud injection in a single-stage transonic axial compressor is proposed. A parametric study of the effect of stator shroud injection on aerodynamic performances was conducted using the three-dimensional Reynolds-averaged Navier-Stokes equations. The curvature, length, width, and circumferential angle of the stator shroud injector and the air injection mass flow rate were selected as the test parameters. The results of the parametric study show that the aerodynamic performances of the single-stage transonic axial compressor were improved by stator shroud injection. The aerodynamic performances were the most sensitive to the injection mass flow rate. Further, the total pressure ratio and adiabatic efficiency were the maximum when the ratio of circumferential angle was 10%.

  14. Effects of Stator Shroud Injection on the Aerodynamic Performance of a Single-Stage Transonic Axial Compressor

    Energy Technology Data Exchange (ETDEWEB)

    Dinh, Cong-Truong; Ma, Sang-Bum; Kim, Kwang Yong [Inha Univ., Incheon (Korea, Republic of)

    2017-01-15

    In this study, stator shroud injection in a single-stage transonic axial compressor is proposed. A parametric study of the effect of stator shroud injection on aerodynamic performances was conducted using the three-dimensional Reynolds-averaged Navier-Stokes equations. The curvature, length, width, and circumferential angle of the stator shroud injector and the air injection mass flow rate were selected as the test parameters. The results of the parametric study show that the aerodynamic performances of the single-stage transonic axial compressor were improved by stator shroud injection. The aerodynamic performances were the most sensitive to the injection mass flow rate. Further, the total pressure ratio and adiabatic efficiency were the maximum when the ratio of circumferential angle was 10%.

  15. Aerodynamic Performance of a Compact, High Work-Factor Centrifugal Compressor at the Stage and Subcomponent Level

    Science.gov (United States)

    Braunscheidel, Edward P.; Welch, Gerard E.; Skoch, Gary J.; Medic, Gorazd; Sharma, Om P.

    2015-01-01

    The measured aerodynamic performance of a compact, high work-factor, single-stage centrifugal compressor, comprising an impeller, diffuser, 90deg-bend, and exit guide vane is reported. Performance levels are based on steady-state total-pressure and total-temperature rake and angularity-probe data acquired at key machine rating planes during recent testing at NASA Glenn Research Center. Aerodynamic performance at the stage level is reported for operation between 70 to 105 percent of design corrected speed, with subcomponent (impeller, diffuser, and exit-guide-vane) flow field measurements presented and discussed at the 100 percent design-speed condition. Individual component losses from measurements are compared with pre-test CFD predictions on a limited basis.

  16. High performance work systems and employee well-being: a two stage study of a rural Australian hospital.

    Science.gov (United States)

    Young, Suzanne; Bartram, Timothy; Stanton, Pauline; Leggat, Sandra G

    2010-01-01

    This paper aims to explore the attitudes of managers and employees to high performance work practices (HPWS) in a medium sized rural Australian hospital. The study consists of two stages. Stage one involved a qualitative investigation consisting of interviews and focus group sessions with senior, middle and line management at the hospital. Bowen and Ostroffs framework was used to examine how strategic HRM was understood, interpreted and operationalised across the management hierarchy. Stage one investigates the views of managers concerning the implementation of strategic HRM/HPWS. Stage two consisted of a questionnaire administered to all hospital employees. The mediation effects of social identification on the relationship between high performance work systems and affective commitment and job satisfaction are examined. The purpose of stage two was to investigate the views and effects of SHRM/HPWS on employees. It should be noted that HPWS and strategic HRM are used inter-changeably in this paper. At the management level the importance of distinctiveness, consistency and consensus in the interpretation of strategic HRM/HPWS practices across the organization was discovered. Findings indicate that social identification mediates the relationship between HPWS and affective commitment and also mediates the relationship between HPWS and job satisfaction. High performance work systems may play a crucial role facilitating social identification at the unit level. Such practices and management support is likely to provide benefits in terms of high performing committed employees. The paper argues that team leaders and managers play a key role in building social identification within the team and that organizations need to understand this role and provide recognition, reward, education and support to their middle and lower managers.

  17. Disease Stage-Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy.

    Science.gov (United States)

    Güçlü, Ahmet; Knaapen, Paul; Harms, Hendrik J; Parbhudayal, Rahana Y; Michels, Michelle; Lammertsma, Adriaan A; van Rossum, Albert C; Germans, Tjeerd; van der Velden, Jolanda

    2017-05-01

    Reduced myocardial efficiency represents a target for therapy in hypertrophic cardiomyopathy although therapeutic benefit may depend on disease stage. Here, we determined disease stage-dependent changes in myocardial efficiency and effects of myectomy surgery. Myocardial external efficiency (MEE) was determined in 27 asymptomatic mutation carriers (genotype positive/phenotype negative), 10 patients with hypertrophic obstructive cardiomyopathy (HOCM), 10 patients with aortic valve stenosis, and 14 healthy individuals using [ 11 C]-acetate positron emission tomography and cardiovascular magnetic resonance imaging. Follow-up measurements were performed in HOCM and aortic valve stenosis patients 4 months after surgery. External work did not differ in HOCM compared with controls, whereas myocardial oxygen consumption was lower in HOCM. Because of a higher cardiac mass, total cardiac oxygen consumption was significantly higher in HOCM than in controls and genotype positive/phenotype negative. MEE was significantly lower in genotype positive/phenotype negative than in controls (28±6% versus 42±6%) and was further decreased in HOCM (22±5%). In contrast to patients with aortic valve stenosis, MEE was not improved in patients with HOCM after surgery, which was explained by opposite changes in the septum (decrease) and lateral (increase) wall. Different mechanisms underlie reduced MEE at the early and advanced stage of hypertrophic cardiomyopathy. The initial increase and subsequent reduction in myocardial oxygen consumption during disease progression indicates that energy deficiency is a primary mutation-related event, whereas mechanisms secondary to disease remodeling underlie low MEE in HOCM. Our data highlight that the benefit of therapies to improve energetic status of the heart may vary depending on the disease stage and that treatment should be initiated before cardiac remodeling. © 2017 American Heart Association, Inc.

  18. Thermodynamic Performance of the 3-Stage ADR for the Astro-H Soft X-Ray Spectrometer Instrument

    Science.gov (United States)

    Shirron, Peter J.; Kimball, Mark O.; James, Bryan L.; Muench, Theodore; DiPirro, Michael J.; Bialas, Thomas G.; Sneiderman, Gary A.; Porter, Frederick S.; Kelley, Richard L.

    2015-01-01

    The Soft X-ray Spectrometer (SXS) instrument[1] on Astro-H[2] will use a 3-stage ADR[3] to cool the microcalorimeter array to 50 mK. In the primary operating mode, two stages of the ADR cool the detectors using superfluid helium at =1.20 K as the heat sink[4]. In the secondary mode, which is activated when the liquid helium is depleted, the ADR uses a 4.5 K Joule-Thomson cooler as its heat sink. In this mode, all three stages operate together to continuously cool the (empty) helium tank and singleshot cool the detectors. The flight instrument - dewar, ADR, detectors and electronics - were integrated in 2014 and have since undergone extensive performance testing. This paper presents a thermodynamic analysis of the ADR's operation, including cooling capacity, heat rejection to the heat sinks, and various measures of efficiency.

  19. Analysis of the Concept and Implementation Status of Performance Based Regulation for Nuclear Power Plants

    International Nuclear Information System (INIS)

    Ahn, Sangkyu; Chang, Gunhyun; Yune, Younggill; Ahn, Hyungjoon; Chang, Wonjoon; Cho, Seungho

    2013-01-01

    To have better understanding of performance based regulation, the concept of performance based regulation, its advantages and disadvantages, and implementation status have been analyzed. The results are described herein. Also, the success conditions to implement the approach are presented. Performance based regulation is one of useful regulatory approaches. It will contribute to the enhancement of nuclear regulatory system's effectiveness and efficiency. Examples include improving the objectivity and transparency of regulatory decision-making, promoting licensee flexibility in response to regulatory requirements that can reduce licensee burden, and promoting safety by focusing achievement of performance goal. To implement it successfully, there are some conditions to be satisfied as follows; · sufficient understanding of the concept of performance based regulation, · combination with risk-informed regulation to create synergy effect, · sufficient communication between regulators and regulated entities prior to implement it, · production and maintenance of reliable performance data by the regulated entities, and · social consensus on performance based regulation. Also, expanding use of performance based regulation will be helpful to the effective regulatory source management and the promotion of voluntary safety activities

  20. Developing an inventor support service which performs early stage market and manufacturing evaluations. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

  1. Developing an inventor support service which performs early stage market and manufacturing evaluations. [Final Report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

  2. Performance Evaluation of Staged Bosch Process for CO2 Reduction to Produce Life Support Consumables

    Science.gov (United States)

    Vilekar, Saurabh A.; Hawley, Kyle; Junaedi, Christian; Walsh, Dennis; Roychoudhury, Subir; Abney. Morgan B.; Mansell, James M.

    2012-01-01

    Utilizing carbon dioxide to produce water and hence oxygen is critical for sustained manned missions in space, and to support both NASA's cabin Atmosphere Revitalization System (ARS) and In-Situ Resource Utilization (ISRU) concepts. For long term missions beyond low Earth orbit, where resupply is significantly more difficult and costly, open loop ARS, like Sabatier, consume inputs such as hydrogen. The Bosch process, on the other hand, has the potential to achieve complete loop closure and is hence a preferred choice. However, current single stage Bosch reactor designs suffer from a large recycle penalty due to slow reaction rates and the inherent limitation in approaching thermodynamic equilibrium. Developmental efforts are seeking to improve upon the efficiency (hence reducing the recycle penalty) of current single stage Bosch reactors which employ traditional steel wool catalysts. Precision Combustion, Inc. (PCI), with support from NASA, has investigated the potential for utilizing catalysts supported over short-contact time Microlith substrates for the Bosch reaction to achieve faster reaction rates, higher conversions, and a reduced recycle flows. Proof-of-concept testing was accomplished for a staged Bosch process by splitting the chemistry in two separate reactors, first being the reverse water-gas-shift (RWGS) and the second being the carbon formation reactor (CFR) via hydrogenation and/or Boudouard. This paper presents the results from this feasibility study at various operating conditions. Additionally, results from two 70 hour durability tests for the RWGS reactor are discussed.

  3. Performance evaluation of a once-through multi-stage flash distillation system: Impact of brine heater fouling

    International Nuclear Information System (INIS)

    Baig, Hasan; Antar, Mohamed A.; Zubair, Syed M.

    2011-01-01

    Multi-stage flash distillation (MSF) system modeling involves a number of process variables. An estimation of all these process variables requires both analytical solutions and experimental/field analysis. However, the accurate estimate of variables related to the brine heater operation in a MSF system is very important for a reliable operation of the system. For example, steam operating conditions as well as the brine properties including fouling of the brine heater tubes have a significant effect on the heat transfer characteristics of the brine heater, which in turn influence the distillate output from the system. In this study, the effect of various design as well as operating conditions on the performance ratio (PR), brine temperature and salinity as it leaves the last flash stage are investigated in a once-through system. Increasing the number of stages from 24 to 32 has a significant effect on the PR, it ranges between 79% (for ΔT = 1.5) and 327% (for ΔT = 2.3) for a top-brine temperature of 106 o C. This value increase as the top-brine temperature increases. Increasing the stage-to-stage temperature difference increases the water salinity as it leaves the final stage and reduces its temperature that would imply better energy utilization within the plant. Results show that brine side heat exchanger fouling has a significant effect in decreasing the overall heat transfer coefficient, which reduces the production rate as the fouling increases with time. A sensitivity analysis to identify the key parameters, which can have a significant influence on the desalination plant performance, is carried out in an attempt to contribute a better understanding and operation of MSF desalination processes.

  4. An evaluation on time status of functional orthopedic treatment in class II skeletal patients with cervical vertebrae maturation stage (CVMS index

    Directory of Open Access Journals (Sweden)

    Dalili Z.

    2004-08-01

    Full Text Available Statement of Problem: Considerable response to functional orthopedic appliances treatment in class II skeletal patients occurs during pubertal growth spurt. Therefore, it seems necessary to investigate indices indicating mandibular growth pattern. It has been proved that analyzing cervical vertebral maturation stage is a more valid index than that of hand wrist. Purpose: The aim of this study was to evaluate the time status of functional orthopedic treatment in class II skeletal patients using CVMS index. Materials and Methods: In this descriptive-inferential study, lateral cephalometric radiographs of 153 class II skeletal patients with mandibular deficiency, before treatment, were studied by an oral and maxillofacial radiologist using the index of cervical vertebral maturation stage (CVMS and were categorized in three phases: CVMS I (desirable phase of treatment, CVMS II (ideal phase, and CVMS III (undesirable phase of treatment. Results: Statistical analysis ranked the prevalence of treatment phases as: 41.8% in desirable phase (CVMS I, 28.1% in ideal phase (CVMA II and 30% in undesirable phase (CVMS III. No significant differences were found between the three phases using Chi-square analysis. Time status of functional orthopedic treatment was also evaluated based on age and sex. The results showed significant differences between two sexes (P=0.032. Conclusion: The present study suggests the analysis of CVMS index, along with clinical criteria, in the determination of an ideal time for functional orthopedic treatment to prevent patients’ exhaustion during treatment Period.

  5. Annual Status Report (FY2016) Performance Assessment for the Environmental Restoration Disposal Facility

    Energy Technology Data Exchange (ETDEWEB)

    Casbon, M. A. [CH2M HILL Plateau Remediation Company, Richland, WA (United States); Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2017-03-15

    DOE O 435.1, Radioactive Waste Management, and DOE M 435.1-1, Radioactive Waste Management Manual, require that a determination of continued adequacy of the performance assessment (PA), composite analysis (CA), and disposal authorization statement (DAS) be made on an annual basis, and it must consider the results of data collection and analysis from research, field studies, and monitoring. Annual summaries of low-level waste (LLW) disposal operations must be prepared with respect to the conclusions and recommendations of the PA and CA, and a determination of the need to revise the PA or CA must be made. The annual summary requirement provides a structured approach for demonstrating the continued adequacy of the PA and CA in demonstrating a reasonable expectation that the performance objectives will be met. This annual summary addresses only the status of the Environmental Restoration Disposal Facility (ERDF) PA (CP-60089, Performance Assessment for the Environmental Restoration Disposal Facility, Hanford Site, Washington, formerly WCH-520 Rev. 1)1. The CA for ERDF is supported by DOE/RL-2016-62, Annual Status Report (FY 2016): Composite Analysis of Low Level Waste Disposal in the Central Plateau at the Hanford Site. The ERDF PA portion of the CA document is found in Section 3.1.4, and the ERDF operations portion is found in Section 3.3.3.2 of that document.

  6. Differences in eating behaviors and masticatory performances by gender and obesity status.

    Science.gov (United States)

    Park, Soojin; Shin, Weon-Sun

    2015-01-01

    This study aimed to determine whether there might be differences in masticatory performance and eating behaviors by gender and obesity status. Forty eight (24 males; 24 females) non-obese and pre-obese young adults were matched for age, gender, and dental health. Eating behaviors were assessed using the Three-Factor Eating Questionnaire (TFEQ), and chewing performance while eating 152g of boiled rice was measured using electromyography (EMG). Compared with non-obese participants, pre-obese participants had significantly higher levels of disinhibition according to the TFEQ (Pdifferent by gender but not by obesity status. Males had a greater bite size (Pobese) and chewing power (r=-0.581, Pobese and r=-0.446, Pobese) were negatively associated with disinhibition score. Results suggest that the effects of gender and, in part, obesity on eating responses may be explained as chewing performance. Therefore, gender-specific interventions and counseling aimed at slowing the rate of ingestion could be promising behavioral treatments for obese persons. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Pre-Clinical Grades Predict Clinical Performance in the MBBS Stage ...

    African Journals Online (AJOL)

    olayemitoyin

    Summary: In the preclinical sciences, statistically significant predictive values have been reported between the performances in one discipline and the others, supporting the hypothesis that students who perform well in one discipline were likely to perform well in the other disciplines. We therefore decided to conduct a ...

  8. Reactivity Insertion Accident (RIA) Capability Status in the BISON Fuel Performance Code

    Energy Technology Data Exchange (ETDEWEB)

    Williamson, Richard L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Folsom, Charles Pearson [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pastore, Giovanni [Idaho National Lab. (INL), Idaho Falls, ID (United States); Veeraraghavan, Swetha [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-05-01

    One of the Challenge Problems being considered within CASL relates to modelling and simulation of Light Water Reactor LWR) fuel under Reactivity Insertion Accident (RIA) conditions. BISON is the fuel performance code used within CASL for LWR fuel under both normal operating and accident conditions, and thus must be capable of addressing the RIA challenge problem. This report outlines required BISON capabilities for RIAs and describes the current status of the code. Information on recent accident capability enhancements, application of BISON to a RIA benchmark exercise, and plans for validation to RIA behavior are included.

  9. The influence of learning styles, enrollment status and gender on academic performance of optometry undergraduates.

    Science.gov (United States)

    Prajapati, Bhavna; Dunne, Mark; Bartlett, Hannah; Cubbidge, Robert

    2011-01-01

    This cross-sectional study was designed to determine whether the academic performance of optometry undergraduates is influenced by enrollment status, learning style or gender. Three hundred and sixty undergraduates in all 3 years of the optometry degree course at Aston University during 2008-2009 were asked for their informed consent to participate in this study. Enrollment status was known from admissions records. An Index of Learning Styles (http://www4.nscu.edu/unity/lockers/users/f/felder/public/Learning-Styles.html) determined learning style preference with respect to four different learning style axes; active-reflective, sensing-intuitive, visual-verbal and sequential-global. The influence of these factors on academic performance was investigated. Two hundred and seventy students agreed to take part (75% of the cohort). 63% of the sample was female. There were 213 home non-graduates (entrants from the UK or European Union without a bachelor's degree or higher), 14 home graduates (entrants from the UK or European Union with a bachelor's degree or higher), 28 international non-graduates (entrants from outside the UK or European Union without a bachelor's degree or higher) and 15 international graduates (entrants from outside the UK or European Union with a bachelor's degree or higher). The majority of students were balanced learners (between 48% and 64% across four learning style axes). Any preferences were towards active, sensing, visual and sequential learning styles. Of the factors investigated in this study, learning styles were influenced by gender; females expressed a disproportionate preference for the reflective and visual learning styles. Academic performance was influenced by enrollment status; international graduates (95% confidence limits: 64-72%) outperformed all other student groups (home non graduates, 60-62%; international non graduates, 55-63%) apart from home graduates (57-69%). Our research has shown that the majority of optometry students

  10. Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment.

    Science.gov (United States)

    van der Meij, Barbara S; Langius, Jacqueline A E; Smit, Egbert F; Spreeuwenberg, Marieke D; von Blomberg, B Mary E; Heijboer, Annemieke C; Paul, Marinus A; van Leeuwen, Paul A M

    2010-10-01

    Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), (n-3) fatty acids from fish oil, have immune-modulating effects and may improve nutritional status in cancer. The objective of this study was to investigate the effects of an oral nutritional supplement containing (n-3) fatty acids on nutritional status and inflammatory markers in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment. In a double-blind experiment, 40 patients with stage III NSCLC were randomly assigned to receive 2 cans/d of a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids (2.0 g EPA + 0.9 g DHA/d) or an isocaloric control supplement. EPA in plasma phospholipids, energy intake, resting energy expenditure (REE), body weight, fat free mass (FFM), mid-upper arm circumference (MUAC), and inflammatory markers were assessed. Effects of intervention were analyzed by generalized estimating equations and expressed as regression coefficients (B). The intervention group (I) had a better weight maintenance than the control (C) group after 2 and 4 wk (B = 1.3 and 1.7 kg, respectively; P oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC.

  11. Performance of the rebuilt SUERC single-stage accelerator mass spectrometer

    Science.gov (United States)

    Shanks, Richard P.; Ascough, Philippa L.; Dougans, Andrew; Gallacher, Paul; Gulliver, Pauline; Rood, Dylan H.; Xu, Sheng; Freeman, Stewart P. H. T.

    2015-10-01

    The SUERC bipolar single-stage accelerator mass spectrometer (SSAMS) has been dismantled and rebuilt to accommodate an additional rotatable pre-accelerator electrostatic spherical analyser (ESA) and a second ion source injector. This is for the attachment of an experimental positive-ion electron cyclotron resonance (ECR) ion source in addition to a Cs-sputter source. The ESA significantly suppresses oxygen interference to radiocarbon detection, and remaining measurement interference is now thought to be from 13C injected as 13CH molecule scattering off the plates of a second original pre-detector ESA.

  12. Eye of the Beholder: Stage Entrance Behavior and Facial Expression Affect Continuous Quality Ratings in Music Performance

    Directory of Open Access Journals (Sweden)

    Aaron Williamon

    2017-04-01

    Full Text Available Judgments of music performance quality are commonly employed in music practice, education, and research. However, previous studies have demonstrated the limited reliability of such judgments, and there is now evidence that extraneous visual, social, and other “non-musical” features can unduly influence them. The present study employed continuous measurement techniques to examine how the process of forming a music quality judgment is affected by the manipulation of temporally specific visual cues. Video footage comprising an appropriate stage entrance and error-free performance served as the standard condition (Video 1. This footage was manipulated to provide four additional conditions, each identical save for a single variation: an inappropriate stage entrance (Video 2; the presence of an aural performance error midway through the piece (Video 3; the same error accompanied by a negative facial reaction by the performer (Video 4; the facial reaction with no corresponding aural error (Video 5. The participants were 53 musicians and 52 non-musicians (N = 105 who individually assessed the performance quality of one of the five randomly assigned videos via a digital continuous measurement interface and headphones. The results showed that participants viewing the “inappropriate” stage entrance made judgments significantly more quickly than those viewing the “appropriate” entrance, and while the poor entrance caused significantly lower initial scores among those with musical training, the effect did not persist long into the performance. The aural error caused an immediate drop in quality judgments that persisted to a lower final score only when accompanied by the frustrated facial expression from the pianist; the performance error alone caused a temporary drop only in the musicians' ratings, and the negative facial reaction alone caused no reaction regardless of participants' musical experience. These findings demonstrate the importance of

  13. Eye of the Beholder: Stage Entrance Behavior and Facial Expression Affect Continuous Quality Ratings in Music Performance.

    Science.gov (United States)

    Waddell, George; Williamon, Aaron

    2017-01-01

    Judgments of music performance quality are commonly employed in music practice, education, and research. However, previous studies have demonstrated the limited reliability of such judgments, and there is now evidence that extraneous visual, social, and other "non-musical" features can unduly influence them. The present study employed continuous measurement techniques to examine how the process of forming a music quality judgment is affected by the manipulation of temporally specific visual cues. Video footage comprising an appropriate stage entrance and error-free performance served as the standard condition (Video 1). This footage was manipulated to provide four additional conditions, each identical save for a single variation: an inappropriate stage entrance (Video 2); the presence of an aural performance error midway through the piece (Video 3); the same error accompanied by a negative facial reaction by the performer (Video 4); the facial reaction with no corresponding aural error (Video 5). The participants were 53 musicians and 52 non-musicians ( N = 105) who individually assessed the performance quality of one of the five randomly assigned videos via a digital continuous measurement interface and headphones. The results showed that participants viewing the "inappropriate" stage entrance made judgments significantly more quickly than those viewing the "appropriate" entrance, and while the poor entrance caused significantly lower initial scores among those with musical training, the effect did not persist long into the performance. The aural error caused an immediate drop in quality judgments that persisted to a lower final score only when accompanied by the frustrated facial expression from the pianist; the performance error alone caused a temporary drop only in the musicians' ratings, and the negative facial reaction alone caused no reaction regardless of participants' musical experience. These findings demonstrate the importance of visual information in

  14. Performance of a Liner-on-Target Injector for Staged Z-Pinch Experiments

    Science.gov (United States)

    Conti, F.; Valenzuela, J. C.; Narkis, J.; Krasheninnikov, I.; Beg, F.; Wessel, F. J.; Ruskov, E.; Rahman, H. U.; McGee, E.

    2016-10-01

    We present the design and characterization of a compact liner-on-target injector, used in the Staged Z-pinch experiments conducted on the UNR-NTF Zebra Facility. Previous experiments and analysis indicate that high-Z gas liners produce a uniform and efficient implosion on a low-Z target plasma. The liner gas shell is produced by an annular solenoid valve and a converging-diverging nozzle designed to achieve a collimated, supersonic, Mach-5 flow. The on-axis target is produced by a coaxial plasma gun, where a high voltage pulse is applied to ionize neutral gas and accelerate the plasma by the J-> × B-> force. Measurements of the liner and target dynamics, resolved by interferometry in space and time, fast imaging, and collection of the emitted light, are presented. The results are compared to the predictions from Computational Fluid Dynamics and MHD simulations that model the injector. Optimization of the design parameters, for upcoming Staged Z-pinch experiments, will be discussed. Advanced Research Projects Agency - Energy, DE-AR0000569.

  15. Cloud service performance evaluation: status, challenges, and opportunities – a survey from the system modeling perspective

    Directory of Open Access Journals (Sweden)

    Qiang Duan

    2017-05-01

    Full Text Available With rapid advancement of Cloud computing and networking technologies, a wide spectrum of Cloud services have been developed by various providers and utilized by numerous organizations as indispensable ingredients of their information systems. Cloud service performance has a significant impact on performance of the future information infrastructure. Thorough evaluation on Cloud service performance is crucial and beneficial to both service providers and consumers; thus forming an active research area. Some key technologies for Cloud computing, such as virtualization and the Service-Oriented Architecture (SOA, bring in special challenges to service performance evaluation. A tremendous amount of effort has been put by the research community to address these challenges and exciting progress has been made. Among the work on Cloud performance analysis, evaluation approaches developed with a system modeling perspective play an important role. However, related works have been reported in different sections of the literature; thus lacking a big picture that shows the latest status of this area. The objectives of this article is to present a survey that reflects the state of the art of Cloud service performance evaluation from the system modeling perspective. This articles also examines open issues and challenges to the surveyed evaluation approaches and identifies possible opportunities for future research in this important field.

  16. Caries status in young Colombian children expressed by the ICCMS™ visual/radiographic combined caries staging system

    DEFF Research Database (Denmark)

    Cortes, Andrea; Ekstrand, Kim Rud; Gamboa, Luis Fernando

    2017-01-01

    OBJECTIVE: To report (1) the caries experience prevalence and mean, and the caries severity and distribution patterns, expressed clinically and combined with radiographs with the conventional and ICCMS™ systems in young children from Bogotá, Colombia; (2) the contribution of including radiographs...... to the clinical caries scoring and (3) in which surfaces the radiograph adds to the clinical caries registration. MATERIAL AND METHODS: Six hundred children from kindergartens/schools were enrolled: Cohort A: 2-year (n = 200), Cohort B: 4-year (n = 200) and Cohort C: 6-year (n = 200) olds. Radiographs were taken...... of the 4- and 6- year olds. Children were examined clinically using the Clinical (C) and Radiographic (R) ICCMS™-epi Caries Scoring Systems, staging caries lesions (d) as: Initial (Cepi/RA), Moderate (CM/RB) or Extensive (CE/RC). Caries experience including missing (m) and filled (f) surfaces was expressed...

  17. Egg Cannibalism and its Life History Consequences Vary with Life Stage, Sex, and Reproductive Status in Hippodamia convergens (Coleoptera: Coccinellidae).

    Science.gov (United States)

    Bayoumy, Mohamed H; Michaud, J P

    2015-08-01

    Egg cannibalism is common in Coccinellidae, but its biological consequences have not been fully explored. We examined egg cannibalism by neonates, fourth instars, and adults of Hippodamia convergens Guerin-Meneville for effects on development, reproduction, and progeny fitness. We also tested female adults for ability to avoid cannibalizing their own eggs and first-instar larvae, and both sexes for changes in cannibalism propensity following mating, all in the presence of ad libitum food [larvae: eggs of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae), adults: Schizaphis graminum (Rondani)]. Cannibalism by neonates reduced developmental time and increased male body size. Cannibalism in the fourth instar accelerated pupation and led to the production of eggs that hatched faster, regardless of which parent cannibalized. However, egg fertility was improved only by maternal cannibalism in the fourth instar. Females recognized their own egg clusters, sometimes added eggs to them, and preferentially cannibalized nonfilial clusters. Most gravid females cannibalized a first-instar larva within 30 min, whether filial or not. Adult egg cannibalism was similar for virgin males and females, but declined after mating in males, and increased in females, although it had no effect on fecundity or fertility. Daughters of cannibal pairs were heavier than those of other mating combinations, but offspring of noncannibal parents had the fastest development. Reproductive females appeared to use egg cannibalism to reduce risk for their own eggs, increasing the number cannibalized with the number laid. Thus, egg cannibalism in coccinellids varies with life stage, sex, and reproductive condition, independent of food availability, and benefits are life stage specific. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status.

    Science.gov (United States)

    Bruzgielewicz, Antoni; Osuch-Wojcikiewicz, Ewa; Niemczyk, Kazimierz; Sieniawska-Buccella, Olga; Siwak, Mateusz; Walczak, Anna; Nowak, Alicja; Majsterek, Ireneusz

    2017-07-01

    It has been reported that microRNAs (miRNAs) are responsible for acquiring all the hallmarks of cancer cells, as well as have a significant impact on the clinical management of cancers at every stage, including prognosis, remission, relapse, and metastasis. In this study, we investigated the association of miR-29a-3p, miR-202-3p, miR-3713, miR-4768-3p, and miR-548aa expression with clinicopathologic features in patients suffering from laryngeal cancer (LC) and determined the potential role of studied miRNAs in the progression of LC. The study group consisted of 48 patients with untreated primary tumors of head and neck cancer localized in the larynx. Expression of the selected miRNAs was verified by the qRT-PCR technique. We showed that the expression of miR-29a as well as miR-548aa was positively correlated with tumor stage and lymph node metastasis, whereas the expression of miR-4768-3p was negatively correlated with lymph node metastasis. Furthermore, we investigated that exposure to cigarette smoke altered miRNA expression profile in LC. The expression level of miR-202-3p was significantly increased in smoking patients compared with nonsmokers, whereas the miR-4768-3p, miR-548aa, and miR-3713 were markedly decreased. Our research contributed toward better elucidating the mechanisms underlying the progression of LC as well as the use of miRNAs inhibitors as novel agents against progression and metastasis of LC.

  19. Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy

    Science.gov (United States)

    Hsieh, Meng-Heng; Wang, Tsai-Yu; Yu, Chih-Teng; Chou, Chun-Liang; Lin, Shu-Min; Kuo, Chih-Hsi; Chung, Fu-Tsai

    2014-01-01

    Although malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly a palliative treatment. Clinical data on postcryotherapy MEM patients in a university-affiliated hospital between 2007 and 2011 were evaluated. Survival curve with or without postcryotherapy chemotherapy and performance status (PS) improvement of these subjects were analyzed using the Kaplan-Meier method. There were 59 patients (42 males), with median age of 64 years (range, 51–76, and median performance status of 2 (interquartile range [IQR], 2-3). Postcryotherapy complications included minor bleeding (n = 12) and need for multiple procedures (n = 10), while outcomes were relief of symptoms (n = 51), improved PS (n = 45), and ability to receive chemotherapy (n = 40). The survival of patients with chemotherapy postcryotherapy was longer than that of patients without such chemotherapy (median, 534 versus 106 days; log-rank test, P = 0.007; hazard ratio, 0.25; 95% confidence interval, 0.10–0.69). The survival of patients with PS improvement postcryotherapy was longer than that of patients without PS improvement (median, 406 versus 106 days; log-rank test, P = 0.02; hazard ratio, 0.28; 95% confidence interval, 0.10–0.81). Cryotherapy is a feasible treatment for MEM. With better PS after cryotherapy, further chemotherapy becomes possible for patients to improve survival when MEM caused dyspnea and poor PS. PMID:25383370

  20. The effect of cognitive status and visuospatial performance on affective theory of mind in Parkinson's disease.

    Science.gov (United States)

    McKinlay, Audrey; Albicini, Michelle; Kavanagh, Phillip S

    2013-01-01

    It is now well accepted that theory of mind (ToM) functioning is impaired in Parkinson's disease (PD) patients. However, what remain unknown are the functions that underlie this impairment. It has been suggested that cognitive skills may be key in this area of functioning; however, many of the cognitive tests used to assess this have relied on intact visuospatial abilities. This study aimed to examine whether deficits in ToM were generated by cognitive or visuospatial dysfunction and the mediating effect of visuospatial function on ToM performance. Fifty PD patients (31 male, 19 female; mean age = 66.34 years) and 49 healthy controls (16 male, 33 female; mean age = 67.29 years) completed a ToM task (reading the mind in the eyes) and visuospatial task (line orientation). The results revealed that current cognitive status was a significant predictor for performance on the ToM task, and that 54% of the total effect of cognitive status on ToM was mediated by visuospatial abilities. It was concluded that visuospatial functioning plays an important mediating role for the relationship between executive dysfunction and affective ToM deficits in PD patients, and that visuospatial deficits may directly contribute to the presence of affective ToM difficulties seen in individuals with PD.

  1. Doing better (or worse) than one's parents: Social status, mobility, and performance-avoidance goals.

    Science.gov (United States)

    Jury, Mickaël; Bruno, Alisée; Darnon, Céline

    2018-01-11

    Previous research has shown that, when succeeding in higher education, first-generation (FG) students endorse more performance-avoidance goals (i.e., the fear of performing poorly) than continuing-generation (CG) students. In this study, individual mobility is examined as a predictor of performance-avoidance goal endorsement. It is argued that FG students endorse more these goals than CG students because in higher education, the former (but not the latter) experience upward mobility. In addition, CG can also be at risk of endorsing these goals when they are confronted with downward mobility. Two studies were conducted with psychology students (N = 143 in Study 1; N = 176 in Study 2). In Study 1, FG and CG students' perceived upward mobility was measured. In Study 2, FG and CG students were provided with a feedback that suggested either upward or downward mobility. In both studies, participants reported their level of performance-avoidance goal endorsement. Results from Study 1 supported an indirect effect of status on performance-avoidance goals via a higher perception of upward mobility. Results from Study 2 supported that psychology students who face mobility (i.e., FG students who received better feedback than their usual level of performance, CG students who received worse feedback than their usual level of performance) increased their performance-avoidance goals the most. Taken together, the results of these studies support that one's actual social position and, even more, the social position one is about to reach are reliable predictors of performance-avoidance goals. © 2018 The British Psychological Society.

  2. Improved DESI-MS Performance using Edge Sampling and aRotational Sample Stage

    Energy Technology Data Exchange (ETDEWEB)

    Kertesz, Vilmos [ORNL; Van Berkel, Gary J [ORNL

    2008-01-01

    The position of the surface to be analyzed relative to the sampling orifice or capillary into the mass spectrometer has been known to dramatically affect the observed signal levels in desorption electrospray ionization mass spectrometry (DESIMS). In analyses of sample spots on planar surfaces, DESI-MS signal intensities as much as five times greater were routinely observed when the bottom of the sampling capillary was appropriately positioned beneath the surface plane ( edge sampling") compared to when the capillary just touched the surface. To take advantage of the optimum "edge sampling" geometry and to maximize the number of samples that could be analyzed in this configuration, a rotational sample stage was integrated into a typical DESI-MS setup. The rapid quantitative determination of caffeine in two diet sport drinks (Diet Turbo Tea, Speed Stack Grape) spiked with an isotopically labeled internal standard demonstrated the utility of this approach.

  3. Multi-Stage ADRs for Current and Future Astronomy Missions: Performance and Requirements for Cryogen-Free Operation

    Science.gov (United States)

    Shirron, Peter; Kimball, Mark; Vlahacos, Kosta

    2010-01-01

    The cooling requirements for current (e.g. Astro-H) and future (e.g. IXO and ASP) astronomy missions pose significant challenges for the sub-Kelvin Cooler. In particular, the use of large detector arrays increases the cooling power needed, and the variety of cryocoolers that can be used for pre-cooling greatly expands the range of temperatures at which the sub-Kelvin cooler can be designed to reject heat. In most cases, there is also a need for a stable higher temperature stage for cooling amplifiers or telescope components. NASA/GSFC is currently building a 3-stage ADR for the Astro-H mission, and is developing a 5-stage ADR suitable for IXO and ASP, as well as many other missions in the early planning stages. The architecture of these ADRs allows them to be adapted rather easily for different cooling requirements and to accommodate different cryocooler capabilities (operating temperature and cooling power). This paper will discuss the performance of these ADRs, which operate in both continuous, and single-shot cooling modes, and the minimum cryocooler capabilities needed to meet the requirements of future missions.

  4. The research and test of the cavitation performance of first stage impeller of centrifugal charging pump in nuclear power stations

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Rongsheng; Fu, Qiang [National Research Center of Pumps, Jiangsu University, Zhenjiang 212013, Jiangsu (China); Liu, Yong, E-mail: beijitadeyouxiang@163.com [National Research Center of Pumps, Jiangsu University, Zhenjiang 212013, Jiangsu (China); He, Bo [Power China SPEM Limited Company, Shanghai 201316 (China); Wang, Xiuli [National Research Center of Pumps, Jiangsu University, Zhenjiang 212013, Jiangsu (China)

    2016-04-15

    The safety production is the most important index for nuclear power development, and the CVCS (chemical and volume control system) occupies an important place in safety control system. The CCP (centrifugal charging pump) is an important component of CVCS system and its particularity decides the high requirements on the cavitation performance, so the research on CCP cavitation has great significance. Using the 3D Pro/E software, the paper makes models of the flow passage components of first stage prototype of CCP in nuclear power stations, and completes the cavitation steady-state computation in the case that the high flow rate of first stage prototype reaches Q = 160 m{sup 3}/h using the numerical computation software ANSYS CFX. The cavitation is divided into the following five stages according to its development process: inception operating condition, development operating condition, critical operating condition, serious operating condition and fracture operating condition. The research analyze the flow field, static pressure fields and bubble distribution conditions in the impeller in different cavitation states, and selects the middle flow line, the front shroud flow line and the back shroud flow line from the same blade for the comparative analysis; to verify the reliability of computation, the researcher made a first stage cavitation prototype to verify its hydraulic performance and cavitation performance. After the comparative analysis on the flow field, pressure and bubble distribution conditions of CCP first stage impeller in different cavitation states, the research draws the following conclusions: (1) as the inlet pressure decreases, the cavitation degree increases, the bubble distribution area extends from impeller inlet to impeller outlet and shows different laws in different cavitation states; (2) the generation of cavitation is affected by the pressure changes in impeller passages, and when the inlet pressure decreases, the static pressure in impeller

  5. Narrative and Music: A Flexible Partnership on the Performing Stage and in the Rehearsal Studio

    DEFF Research Database (Denmark)

    Grund, Cynthia M.; Westney, WIlliam

    2011-01-01

    As is indicated by the title, this presentation deals with implemented narrativity on two fronts within the complex process of live musical performance: a “concert story” told by the musician in front of the live audience in the performance situation and a structured complex of verbal and non-ver......-audience relationship. For Grund, a philosopher who also has experience as a performing musician, analyzing this implementation of narrativity is an important part of exploring the formation of musical meaning from a philosophical standpoint in a practicebased context....

  6. High Performance Hybrid Upper Stage for NanoLaunch Vehicles, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Parabilis Space Technologies, Inc (Parabilis), in collaboration with Utah State University (USU), proposes further development of a low-cost, high-performance launch...

  7. Effects of socioeconomic status on esophageal adenocarcinoma stage at diagnosis, receipt of treatment, and survival: A population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Hla-Hla Thein

    Full Text Available The incidence of esophageal adenocarcinoma (EAC is increasing worldwide and has overtaken squamous histology in occurrence. We studied the impact of socioeconomic status (SES on EAC stage at diagnosis, receipt of treatment, and survival. A population-based retrospective cohort study was conducted using Ontario Cancer Registry-linked administrative health data. Multinomial logistic regression was used to examine the association between SES (income quintile and stage at EAC diagnosis and EAC treatment. Survival times following EAC diagnosis were estimated using Kaplan-Meier method. Cox proportional-hazards regression analysis was used to examine the association between SES and EAC survival. Between 2003-2012, 2,125 EAC cases were diagnosed. Median survival for the lowest-SES group was 10.9 months compared to 11.6 months for the highest-SES group; the 5-year survival was 9.8% vs. 15.0%. Compared to individuals in the highest-SES group, individuals in the lowest-SES category experienced no significant difference in EAC treatment (91.6% vs. 93.3%, P = 0.314 and deaths (78.9% vs. 75.6%, P = 0.727. After controlling for covariates, no significant associations were found between SES and cancer stage at diagnosis and EAC treatment. Additionally, after controlling for age, gender, urban/rural residence, birth country, health region, aggregated diagnosis groups, cancer stage, treatment, and year of diagnosis, no significant association was found between SES and EAC survival. Moreover, increased mortality risk was observed among those with older age (P = 0.001, advanced-stage of EAC at diagnosis (P < 0.001, and those receiving chemotherapy alone, radiotherapy alone, or surgery plus chemotherapy (P < 0.001. Adjusted proportional-hazards model findings suggest that there is no association between SES and EAC survival. While the unadjusted model suggests reduced survival among individuals in lower income quintiles, this is no longer significant after adjusting

  8. Beginners on Stage: Arendt, Natality and the Appearance of Children in Contemporary Performance

    OpenAIRE

    Senior, A

    2016-01-01

    This paper examines the complex questions that arise around the appearance of children in contemporary performance. Drawing on performances by Nottingham-based theatre company Zoo Indigo and Tim Etchells and the Flemish theatre company Victoria, I consider the extent to which Hannah Arendt’s theorisation of natality as ‘the new beginning inherent in birth’ that gives rise to the political potential to ‘begin something anew’ can help us to understand the ethico-political dimensions of children...

  9. Performance capacity, fighting tactics and the evolution of life-stage male morphs in the green anole lizard (Anolis carolinensis).

    Science.gov (United States)

    Lailvaux, Simon P; Herrel, Anthony; Vanhooydonck, Bieke; Meyers, Jay J; Irschick, Duncan J

    2004-12-07

    The evolution of alternative male phenotypes is probably driven by male-male competition for access to reproductive females, but few studies have examined whether whole-organism performance capacities differ between male morphs, and if so whether any such differences affect fighting ability. We show how ontogenetic changes in performance and morphology have given rise to two distinct life-stage male morphs exhibiting different fighting tactics within the green anole lizard (Anolis carolinensis). Field studies show a bimodal distribution of adult males within a single population: larger 'heavyweight' males have relatively large heads and high bite forces for their size, whereas smaller 'lightweight' males have smaller heads and lower bite forces. In staged fights between size-matched heavyweight males, males with greater biting ability won more frequently, whereas in lightweight fights, males with greater jumping velocity and acceleration won more often. Because growth in reptiles is indeterminate, and the anole males examined are sexually mature, we propose that the heavyweight morph arose through selection against males with small heads and poor bite forces at the lightweight-heavyweight size transition. Our findings imply that one may not be able to predict male fighting success (and hence potential mating success) by examining aspects of male 'quality' at only one life stage.

  10. Effects of Lactation Stage and Individual Performance on Milk -9, -11 Conjugated Linoleic Acids Content in Dairy Cows

    Directory of Open Access Journals (Sweden)

    T. Wang

    2013-02-01

    Full Text Available The goal of this study was to evaluate the effects of lactation stage and individual performance on milk cis-9, trans-11 conjugated linoleic acid (CLA content in dairy cows. In experiment 1, the milk cis-9, trans-11 CLA content from dairy cows in early (0.33±0.014%, middle (0.37±0.010%, and late stages (0.44±0.020% showed significant differences (p<0.05; and the individual contents of the major fatty acids, especially cis-9, trans-11 CLA in cows of the same lactation were also variable. In the second experiment design as a validation test, our results once again showed that the individual contents of cis-9, trans-11 CLA were various, and a difference of about 2-fold (0.55% vs 0.95% was observed, although the animals were offered same diet. These data demonstrated that lactation stage and individual performance have considerable effects on milk cis-9, trans-11 CLA contents.

  11. A Review on the Role of Chromium Supplementation in Ruminant Nutrition-Effects on Productive Performance, Blood Metabolites, Antioxidant Status, and Immunocompetence

    DEFF Research Database (Denmark)

    Lashkari, Saman; Habibian, Mahmood; Jensen, Søren Krogh

    2018-01-01

    , Cr supplementation improved dry matter intake, milk production, and milk composition of dairy cows in the early, mid, or late stage of lactation. Also, in some studies, performance of growing animal, immune response, and some blood parameters responded positively to Cr supplementation. In conclusion...... microminerals is important. Chromium (Cr) is one of the important micronutrients which plays an important role in metabolism of ruminants. Experimental studies have found that Cr could change performance, immune responses, glucose and fatty acid metabolism, and antioxidant status in dairy cows. In some studies......, the effects of Cr supplementation on performance of ruminants are inconsistent; however, its long-term effects on health, productivity, immune system, and antioxidant activity of ruminants still need to be investigated....

  12. Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil.

    Science.gov (United States)

    Danielewicz, Ana Lúcia; Barbosa, Aline Rodrigues; Del Duca, Giovâni Firpo

    2014-01-01

    To investigate the association between nutritional status and functional limitation and disability in an elderly population in southern Brazil. Epidemiological, cross-sectional household-based study carried out with 477 elderly of both sexes (60 to 100 years). Body mass index (BMI) served to assess the nutritional status: underweight (BMI 27 kg/m2). The sum score (0-5) obtained in three tests: "chair stand" and "pick up a pen" (measured by time) and standing balance (four static measurements) assessed the functional limitation. The disability was evaluated by the difficulty in performing one or more self-reported tasks related to basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Crude and adjusted analyzes (3 models) were carried out using Poisson regression; prevalence ratios (PR) and 95% confidence intervals (CI) were calculated. Crude analyzes showed a positive association between underweight and functional limitation (PR = 2.71, 95% CI = 1.63 to 4.51); overweight and disability in ADLs (PR = 2.20, CI 95% = 1.44 to 3.35); overweight and disability in IADLs (PR = 1.56, CI 95% = 1.20 to 2.03). The additional adjustments for gender, age, level of education, living arrangements, current work, cognitive function and number of morbidities reduced the strength of the associations, without changing the statistical strength. Nutritional status is a factor that is independently and positively associated with functional limitation and disability. We recommend the use of this indicator to monitor the health of the elderly.

  13. Conversion of Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG) to Palliative Performance Scale (PPS), and the interchangeability of PPS and KPS in prognostic tools.

    Science.gov (United States)

    de Kock, Ingrid; Mirhosseini, Mehrnoush; Lau, Francis; Thai, Vincent; Downing, Michael; Quan, Hue; Lesperance, Mary; Yang, Ju

    2013-01-01

    The aim of our study was to assess whether the Karnofsky Performance Status (KPS), the Eastern Cooperative Oncology Group (ECOG) Performance Status, and the Palliative Performance Scale (PPS) are interchangeable individually or within two prognostic tools: the Palliative Prognostic Score (PaP) and the Palliative Prognostic Index (PPI). We performed a subset analysis of a prospective comparative study of functional and prognostic tools and clinician prediction of survival. We studied 955 patients with advanced life-limiting illnesses (cancer and noncancer) in the acute care and community settings. We used a descriptive statistical model and Spearman's rank correlation to assess these interchangeabilities. There is a direct positive linear relationship between the KPS and the PPS, and a direct negative linear relationship between these tools and the ECOG. Exchange of the KPS and the PPS was possible within the PaP and the PPI. The PPS and the KPS can be used interchangeably as functional tools and within prognostic tools. The ECOG is interchangeable with the PPS and the KPS, but this interchangeability is population-specific.

  14. Archaeal and bacterial community dynamics and bioprocess performance of a bench-scale two-stage anaerobic digester.

    Science.gov (United States)

    Gonzalez-Martinez, Alejandro; Garcia-Ruiz, Maria Jesus; Rodriguez-Sanchez, Alejandro; Osorio, Francisco; Gonzalez-Lopez, Jesus

    2016-07-01

    Two-stage technologies have been developed for anaerobic digestion of waste-activated sludge. In this study, the archaeal and bacterial community structure dynamics and bioprocess performance of a bench-scale two-stage anaerobic digester treating urban sewage sludge have been studied by the means of high-throughput sequencing techniques and physicochemical parameters such as pH, dried sludge, volatile dried sludge, acid concentration, alkalinity, and biogas generation. The coupled analyses of archaeal and bacterial communities and physicochemical parameters showed a direct relationship between archaeal and bacterial populations and bioprocess performance during start-up and working operation of a two-stage anaerobic digester. Moreover, results demonstrated that archaeal and bacterial community structure was affected by changes in the acid/alkalinity ratio in the bioprocess. Thus, a predominance of the acetoclastic methanogen Methanosaeta was observed in the methanogenic bioreactor at high-value acid/alkaline ratio, while a predominance of Methanomassilicoccaeceae archaea and Methanoculleus genus was observed in the methanogenic bioreactor at low-value acid/alkaline ratio. Biodiversity tag-iTag sequencing studies showed that methanogenic archaea can be also detected in the acidogenic bioreactor, although its biological activity was decreased after 4 months of operation as supported by physicochemical analyses. Also, studies of the VFA producers and VFA consumers microbial populations showed as these microbiota were directly affected by the physicochemical parameters generated in the bioreactors. We suggest that the results obtained in our study could be useful for future implementations of two-stage anaerobic digestion processes at both bench- and full-scale.

  15. Work status as a predictor of academic performance in the field of distance higher education

    Directory of Open Access Journals (Sweden)

    J. C. Welman

    2003-10-01

    Full Text Available This article reports on the academic success of 13 590 Technikon SA students and the importance of their "work status" (employed/unemployed in light of the co-operative education philosophy of technikons. The data was collected by means of the students’ registration records, and analysed using a CHAID-analysis. The results indicated that the variable "work status" features second last on the list of nine successful variables for predicting academic performance. Generally, it would appear that the employment practice for technikon students is not as important a requirement for academic success as the co-operative education philosophy would like it to be. Opsomming Hierdie artikel lewer verslag oor die akademiese sukses van 13 590 Technikon SA studente en die belangrikheid van hul “werkstatus” (werkend/werkloos in die lig van die koöperatiewe onderwysfilosofie van technikons. Die inligting wat deur middel van die studente se registrasierekords ingesamel is, is ontleed met ‘n CHAID-ontleding. Die resultate toon dat die veranderlike “werkstatus” tweede laaste op die lys van nege veranderlikes voorkom wat akademiese verrigting voorspel. Oor die algemeen blyk dit dat die indiensnemingpraktyk van technikonstudente nie so ‘n belangrike vereiste vir akademiese sukses is as wat die koöperatiewe onderwysfilosofie dit sou wou hê nie.

  16. Science on Stage: Engaging and teaching scientific content through performance art

    Science.gov (United States)

    Posner, Esther

    2016-04-01

    Engaging teaching material through performance art and music can improve the long-term retention of scientific content. Additionally, the development of effective performance skills are a powerful tool to communicate scientific concepts and information to a broader audience that can have many positive benefits in terms of career development and the delivery of professional presentations. While arts integration has been shown to increase student engagement and achievement, relevant artistic materials are still required for use as supplemental activities in STEM (science, technology, engineering, mathematics) courses. I will present an original performance poem, "Tectonic Petrameter: A Journey Through Earth History," with instructions for its implementation as a play in pre-university and undergraduate geoscience classrooms. "Tectonic Petrameter" uses a dynamic combination of rhythm and rhyme to teach the geological time scale, fundamental concepts in geology and important events in Earth history. I propose that using performance arts, such as "Tectonic Petrameter" and other creative art forms, may be an avenue for breaking down barriers related to teaching students and the broader non-scientific community about Earth's long and complex history.

  17. Classroom Performance Evaluation: Stages and Perspectives for Professional Development of Secondary Teachers in Vietnam

    Science.gov (United States)

    Pham, Huy Q.; Roberts, Stacey B.

    2012-01-01

    This study examined classroom performance evaluation of secondary teachers in Vietnam. Specially, it sought to determine the possibility of applying supervision into the evaluation for teaching development. Data were collected from interviews with 34 (n=34) participants: ten evaluators and 24 teachers in different school contexts: rural areas,…

  18. Exercise and physical activity for patients with end-stage liver disease: Improving functional status and sarcopenia while on the transplant waiting list.

    Science.gov (United States)

    Duarte-Rojo, Andrés; Ruiz-Margáin, Astrid; Montaño-Loza, Aldo J; Macías-Rodríguez, Ricardo U; Ferrando, Arny; Kim, W Ray

    2018-01-01

    Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis and end-stage liver disease (ESLD). They are the end result of impaired dietary intake, chronic inflammation, altered macronutrient and micronutrient metabolism, and low physical activity. Frailty is the end result of prolonged sarcopenia and physical deconditioning. It severely affects a patient's functional status and presents in approximately 1 in 5 patients on the liver transplantation waiting list. Sarcopenia, poor physical fitness/cardiopulmonary endurance (CPE), and frailty are all associated with increased mortality in ESLD. Clinical trials addressing the usefulness of exercise in patients with cirrhosis have shown that it improves the metabolic syndrome, sarcopenia, CPE, health-related quality of life, and hepatic venous pressure gradient. Although evidence on the benefits of exercise on clinical outcomes derived from large clinical trials is still missing, based on existing literature from multiple medical subspecialties, we believe that an exercise program coupled to a tailored nutritional intervention benefits both cardiopulmonary and musculoskeletal functions, ultimately translating into improved functional status, sense of well-being, and possibly less complications from portal hypertension. In conclusion, although supervised exercise training is the prevailing approach to manage ESLD patients, such intervention is not sustainable or feasible for most patients. Innovative home-based physical activity interventions may be able to effectively reach a larger number of patients. Liver Transplantation 24 122-139 2018 AASLD. © 2017 by the American Association for the Study of Liver Diseases.

  19. Disparities by Age, Sex, Tumor Stage, Diagnosis Path, and Area-level Socioeconomic Status in Survival Time for Major Cancers: Results from the Busan Cancer Registry.

    Science.gov (United States)

    Kwak, Minjung; Kim, Changhoon

    2017-12-01

    Our goal was to examine the effect of area-level deprivation on patient survival time for seven major cancers - stomach, colon, liver, lung, breast, cervix, and thyroid cancer. Data on 10,902 subjects who were diagnosed with major cancers from 2010 and 2011 in Busan were collected regarding the survival time along with several important prognostic factors and an area-level deprivation index was constructed from education, income, unemployment, and welfare assistance, to assess the comprehensive area-level socioeconomic status. A multilevel Cox proportional hazard model was used to investigate the effects of multiple risk factors such as gender, age, tumor stage, diagnosis path, and the area-level deprivation. After adjusting for risk factors the area-level deprivation index was found to be significant in associating with higher hazard rate for several cancers. Estimated hazard ratios (95% CI) were 1.08 (0.99-1.18), 1.23 (1.12-1.36), 1.36 (1.21-1.53) for the second, the third, and the fourth quartile of deprivation index groups, respectively, when compared to the least deprived group. When compared with the least deprived group, the more deprived group showed significant decrease in survival time for major cancers. This novel finding may contribute to the literature regarding the association of area-level socioeconomic status and highlight the importance of careful monitoring of socioeconomic characteristics for cancer prevention and care services. © 2017 The Korean Academy of Medical Sciences.

  20. Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status.

    Science.gov (United States)

    Patil, Tejas; Aisner, Dara L; Noonan, Sinead A; Bunn, Paul A; Purcell, William T; Carr, Laurie L; Camidge, D Ross; Doebele, Robert C

    2016-06-01

    Peritoneal metastasis from lung cancer is an uncommon clinical event and there are limited data on what factors predict peritoneal progression. This study retrospectively investigated whether patterns of metastatic spread and oncogene status in patients with advanced non-small cell lung cancer (NSCLC) are associated with peritoneal metastasis. Patients with metastatic non-squamous NSCLC (n=410) were identified at the University of Colorado Cancer Center. Sites of metastatic disease and baseline oncogene status (EGFR, ALK, KRAS, or triple negative) were documented via a retrospective chart review. In patients with EGFR mutations who developed peritoneal disease, we documented the presence of known resistance mechanisms. Median time to peritoneal metastasis, time from peritoneal disease to death, and overall survival were collected. Eight percent (33/410) patients in this study developed peritoneal metastasis. Malignant pleural disease at baseline was significantly associated with subsequent peritoneal spread. There was no association between oncogene status and peritoneal metastasis. Three patients with EGFR mutations who developed peritoneal metastasis had documented resistance to tyrosine kinase inhibitors (TKIs) in the ascitic fluid. Median time from stage IV disease to peritoneal metastasis was 16.5 months (range 0.6-108 months). There were no differences in overall survival between patients who developed peritoneal metastasis and those who did not. Malignant pleural disease is highly associated with peritoneal metastasis in patients with advanced NSCLC. The underlying mechanism is not clear. The presence of resistance mutations in ascitic fluid implies that poor drug penetration is unlikely to be the dominant mechanism. Despite being a late clinical finding, there were no differences in overall survival between patients who developed peritoneal metastasis and those who did not. Additional studies exploring treatment related factors in patients with malignant

  1. Influence of light and shoot development stage on leaf photosynthesis and carbohydrate status during the adventitious root formation in cuttings of Corylus avellana L.

    Directory of Open Access Journals (Sweden)

    Sergio eTombesi

    2015-11-01

    Full Text Available Adventitious root formation in plant cuttings is influenced by many endogenous and environmental factors. Leaf photosynthesis during rooting of leafy cuttings in hard to root species can contribute to supply carbohydrates to the intensive metabolic processes related to adventious root formation. Light intensity during rooting is artificially kept low to decrease potential cutting desiccation, but can be limiting for photosynthetic activity. Furthermore, leafy cuttings collected from different part of the shoot can have a different ability to fuel adventitious root formation in cutting stem. The aim of this work was to determine the role of leaf photosynthesis on adventitious root formation in hazelnut (Corylus avellana L (a hard-to-root specie leafy cuttings and to investigate the possible influence of the shoot developmental stage on cutting rooting and survival in the post-rooting phase. Cutting rooting was closely related to carbohydrate content in cutting stems during the rooting process. Cutting carbohydrate status was positively influenced by leaf photosynthesis during rooting. Non saturating light exposure of leafy cuttings can contribute to improve photosynthetic activity of leafy cuttings. Collection of cuttings from different part of the mother shoots influenced rooting percentage and this appear related to the different capability to concentrate soluble sugars in the cutting stem during rooting. Adventitious root formation depend on the carbohydrate accumulation at the base of the cutting. Mother shoot developmental stage and leaf photosynthesis appear pivotal factors for adventitious roots formation.

  2. Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy

    DEFF Research Database (Denmark)

    Helbekkmo, Nina; Aasebø, Ulf; Sundstrøm, Stein H

    2008-01-01

    BACKGROUND: There is no consensus regarding chemotherapy to patients with advanced NSCLC (ANSCLC) and performance status (PS) 2. Using data from a national multicenter study comparing two third-generation carboplatin-based regimens in ANSCLC patients, we evaluated the outcome of PS 2 patients....... PATIENTS AND METHODS: The 123 PS 2 patients were compared to 309 PS 0/1 patients regarding survival, quality of life (QOL) and treatment toxicity. RESULTS: PS 2 patients had lower haemoglobin, lower global QOL and more pain, nausea/vomiting and dyspnea at inclusion. 68% of PS 2 patients received three...... chemotherapy courses vs. 85% in the PS 0/1 group (PPS 2 group, 4.5 vs. 8.9 months and 10% vs. 37% (PPS 2 patients needed blood transfusions (P=0.03) and hospitalization (PPS 2 patients had better relief of pain and dyspnea...

  3. Field performance assessment of synthetic liners for uranium tailings ponds: a status report

    International Nuclear Information System (INIS)

    Mitchell, D.H.; Spanner, G.E.

    1984-03-01

    The objective of this study is to provide a database to support US Nuclear Regulatory Commission (NRC) licensing of uranium tailings leachate isolation impoundments. This objective is being accomplished by determining the effectiveness of design, installation, and quality assurance practices associated with uranium mill tailings impoundments with flexible membrane liners. The program includes testing of chemical resistance and physical performance of liners, leak detection systems, and seam inspection techniques. This report presents the status of the program through September 1983. The report addresses impoundment design, installation, and inspection techniques used by the uranium milling industry. To determine the relative successes of these techniques, information has been collected from consultants, mill operators, and the synthetic liner industry. Progress in experimental tasks on chemical resistance of liners, physical properties of liners, and nondestructive examination of seams is reported. 25 references, 9 figures, 13 tables

  4. Growth performance and oxidative status in piglets supplemented with verbascoside and teupolioside

    Directory of Open Access Journals (Sweden)

    G. Pastorelli

    2010-04-01

    Full Text Available Two hundred forty piglets, half female and half barrows, 8.1 ± 1.40 kg LW, were divided into 6 experimental groups and fed ad libitum with a diet supplemented with the following levels of antioxidants: 0 (CON + = positive control added with 100 mg lincomicine/kg, 5 (LT = low teupolioside or LV = low verbascoside, 10 (HT = high teupolioside; HV = high verbascoside; LT+LV mg/kg of diet for 56 days. Body weight and feed intake were recorded on d0, 14 and 56 of the trial. Ten piglets from each group were selected and blood collected by anterior vena cava puncture at 0, 14 and 56 d for reactive oxygen metabolite (ROMs determination. HV showed final weight higher than the other groups (P<0.05, and oxidative stability was improved by both integrations of verbascoside. These results support the view that Verbascoside influences the growth performances and oxidative status of piglets.

  5. Controlling Energy Performance on the Big Stage - The New York Times Company

    Energy Technology Data Exchange (ETDEWEB)

    Settlemyre, Kevin [Sustainable IQ, Inc., Arlington, MA (United States); Regnier, Cindy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-08-01

    The Times partnered with the U.S. Department of Energy (DOE) as part of DOE’s Commercial Building Partnerships (CBP) Program to develop a post-occupancy evaluation (POE) of three EEMs that were implemented during the construction of The Times building between 2004-2006. With aggressive goals to reduce energy use and carbon emissions at a national level, one strategy of the US Department of Energy is looking to exemplary buildings that have already invested in new approaches to achieving the energy performance goals that are now needed at scale. The Times building incorporated a number of innovative technologies, systems and processes that make their project a model for widespread replication in new and existing buildings. The measured results from the post occupancy evaluation study, the tools and processes developed, and continuous improvements in the performance and cost of the systems studied suggest that these savings are scalable and replicable in a wide range of commercial buildings nationwide.

  6. How to learn and to perform endoscopic ultrasound and endobronchial ultrasound for lung cancer staging

    DEFF Research Database (Denmark)

    Konge, Lars; Colella, Sara; Vilmann, Peter

    2015-01-01

    , and supervised performance on patients. Each step should be completed by passing a validated exam before proceeding to the next step. This approach will assure basic competency on all levels, and testing also facilitates learning and improves retention. Competence in endosonography can be based on a systematic......The learning of transesophageal ultrasound guided fine needle aspiration (FNA) (endoscopic ultrasound-FNA), and endobronchial ultrasound guided transbronchial needle aspiration (endosonography) should be based on the following steps: Acquiring theoretical knowledge, training on simulators...

  7. Globalizing McDonagh: The Playwright in Performance on the World Stage

    OpenAIRE

    Dennis, Krysta

    2015-01-01

    In this thesis, I demonstrate how Martin McDonagh’s plays, both in text and performance, express the destructive, homogenizing, or stereotype-reinforcing element of globalization, as well as the positive elements of globalization including globalized cultural exchange and (g)localization. My original contribution to knowledge is the in-depth research surrounding the effect of globalization on the theatre by using an extremely globalized playwright to demonstrate this phenomenon. The introduct...

  8. Records of performance and sanitary status from a dairy cattle herd in southern Brazil

    Directory of Open Access Journals (Sweden)

    Cláudio E. F. Cruz

    2011-01-01

    Full Text Available Over the last decades, the emphasis on the health of dairy cows has changed from an individual to a herd level. In this scenario, the role played by the recording system and its interpretation by veterinarians has gained primordial importance. The records of productive and reproductive performance and of sanitary status from a southern Brazilian dairy cattle herd have been presented and discussed. The period of study was 2000-2009. Mean values per lactation period were 349D 8436M 290F 275P 201SCS (D: days in lactation, M: kg of milk yield, F: kg of fat, P: kg of protein and SCS: somatic cell score in 1000 cells/ml of milk. Major indexes of reproductive efficiency included age at first calving (31 months, services per conception (2.1, intercalving interval (428 days, calving to conception interval (146 days, mean annual rates of parturitions (76.2%, fetal losses (9.8-19.0%, and stillbirths (3.6%, apart of voluntary waiting period (94 days. Main information on sanitary status of the herd was associated with the mean prevalence of common disorders of dairy cattle such as anaplasmosis (29.8%, mastitis (27.8%, digital diseases (26.3%, ovarian cysts (21.3%, placental retention (19.7%, postpartum uterine infections (10.6%, and calf diarrhea (23.7% and pneumonia (16.8%, among others. In addition, culling reasons (low reproductive performance [56.3%] and udder/mastitis problems [33.6%], causes of cattle deaths (anaplasmosis [16.4%] and leukosis [11.4], and the impact of cattle diseases such as tuberculosis, leukosis, and neosporosis on the herd have also been presented and succinctly discussed. Numbers between brackets represent rates accumulated in the 10-year period.

  9. The Preoperative Controlling Nutritional Status Score Predicts Survival After Curative Surgery in Patients with Pathological Stage I Non-small Cell Lung Cancer.

    Science.gov (United States)

    Shoji, Fumihiro; Haratake, Naoki; Akamine, Takaki; Takamori, Shinkichi; Katsura, Masakazu; Takada, Kazuki; Toyokawa, Gouji; Okamoto, Tatsuro; Maehara, Yoshihiko

    2017-02-01

    The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni- and multivariate Cox regression analyses of postoperative survival. A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95% confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95% CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95% CI=5.900-362.620; pcancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  10. Pacifier use in newborns: related to socioeconomic status but not to early feeding performance.

    Science.gov (United States)

    Pineda, Roberta; Luong, Anhthi; Ryckman, Justin; Smith, Joan

    2018-05-01

    Mothers are often advised not to use pacifiers until breastfeeding has been well-established. This study determined the infant and social factors that were related to pacifier use during the first few days of life and whether it led to alterations in feeding performance. We enroled 51 full-term infants and their mothers at Barnes-Jewish Hospital in urban St. Louis, USA, in 2015. Before they were discharged the mothers completed a questionnaire, and infant feeding was assessed using a standardised assessment. There were 24 (47%) infants who used a pacifier during the first few days of life and seven (29%) of these were exclusively breastfed. Pacifier use was less common among mothers who exclusively breastfed (p = 0.04). Pacifier use was more common among mothers whose income was less than 25 000 US dollars (p = 0.02), who were single (p = 0.002) and who did not have a college education (p = 0.03). No associations between pacifier use and feeding performance were observed. While lower socioeconomic status was related to pacifier use, feeding performance in the first few days of life was no different between those infants who did and did not use pacifiers after a full-term birth. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  11. Schoolteachers' awareness about scholastic performance and nutritional status of Egyptian schoolchildren.

    Science.gov (United States)

    Galal, Osman M; Ismail, Ibrahim; Gohar, Azza S; Foster, Zoë

    2005-06-01

    Malnutrition disorders affect more than 30% of schoolchildren in Egypt. This problem appears to be largely attributable to poor dietary quality and micronutrient deficiencies, such as iron and vitamin A. Inadequate nutrition intake has important implications because malnutrition has been shown to negatively affect the cognitive development of primary schoolchildren. This study assesses the awareness of schoolteachers about the impact of malnutrition on the scholastic performance of primary schoolchildren living in Egypt. Two focus group discussions were conducted with Egyptian schoolteachers from the Quena and Kharbia Governorates. The study indicates that schoolteachers consider low body weight and thinness as the primary signs of malnutrition. They do not prioritize malnutrition as a factor for poor scholastic performance. They also suggest that unhealthful eating habits, especially a lack of breakfast, negatively affect children's interaction with schoolteachers and their ability to excel in their studies. Schoolteachers endorse a more reliable and nutritionally valuable school-feeding program as a way to increase the scholastic performance of their students. The teachers advocate developing integrated programs between the Ministry of Education, the Ministry of Health and Population, teachers, children, and parents that provide nutrition education. A lack of awareness among teachers about the relationship of nutrition and cognitive function can lead to the misdiagnosis or delayed management of malnourished and scholastically challenged schoolchildren. This paper suggests that proper school-feeding programs and nutrition education programs, which integrate government ministries, teachers, children and parents, should be developed to improve the physical and cognitive health status of Egyptian schoolchildren.

  12. High-Speed 3D Printing of High-Performance Thermosetting Polymers via Two-Stage Curing.

    Science.gov (United States)

    Kuang, Xiao; Zhao, Zeang; Chen, Kaijuan; Fang, Daining; Kang, Guozheng; Qi, Hang Jerry

    2018-04-01

    Design and direct fabrication of high-performance thermosets and composites via 3D printing are highly desirable in engineering applications. Most 3D printed thermosetting polymers to date suffer from poor mechanical properties and low printing speed. Here, a novel ink for high-speed 3D printing of high-performance epoxy thermosets via a two-stage curing approach is presented. The ink containing photocurable resin and thermally curable epoxy resin is used for the digital light processing (DLP) 3D printing. After printing, the part is thermally cured at elevated temperature to yield an interpenetrating polymer network epoxy composite, whose mechanical properties are comparable to engineering epoxy. The printing speed is accelerated by the continuous liquid interface production assisted DLP 3D printing method, achieving a printing speed as high as 216 mm h -1 . It is also demonstrated that 3D printing structural electronics can be achieved by combining the 3D printed epoxy composites with infilled silver ink in the hollow channels. The new 3D printing method via two-stage curing combines the attributes of outstanding printing speed, high resolution, low volume shrinkage, and excellent mechanical properties, and provides a new avenue to fabricate 3D thermosetting composites with excellent mechanical properties and high efficiency toward high-performance and functional applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. GRAPE EXTRACT IMPROVES ANTIOXIDANT STATUS AND PHYSICAL PERFORMANCE IN ELITE MALE ATHLETES

    Directory of Open Access Journals (Sweden)

    Sophie Lafay

    2009-09-01

    Full Text Available Excessive physical exercise overproduces reactive oxygen species. Even if elite sportsmen increase their antioxidant status by regular physical training, during the competition period, this improvement is not sufficient to limit free radical production which could be detrimental to the body. The aim of this randomized, double-blind, placebo controlled, and crossover study on 20 elite sportsmen (handball = 10, basketball = 5, sprint = 4, and volleyball = 1 during the competition period was to determine if the consumption of a grape extract (GE; Vitis vinifera L. was able to improve the parameters related to (i anti-oxidative status and oxidative stress and (ii physical performance. Specific biomarkers of antioxidant capacity, oxidative stress, skeletal cell muscle damage, and other general biomarkers were determined in plasma and urine before (D0 and after one month (D30 of placebo or GE supplementation (400mg·d-1. Effort tests were conducted using the Optojump® system, which allows determining the total physical performance (EnRJ45, explosive power (RJ110, and fatigue (RJL5. The plasma ORAC value was not modified in the placebo group; however, GE increased the ORAC value compared to the placebo at D30 (14 966+/-335 vs 14 242+/-339 µmol Teq·L-1; p < 0.05. The plasma FRAP value was significantly reduced in the placebo group, but not in the GE group. Therefore, GE limited the reduction of FRAP compared to the placebo at D30 (1 053.7+/-31.5 vs 993.7+/-26.7 µmol Teq·L-1; p < 0.05. Urinary isoprostane values were increased in the placebo group, but were not modified in the GE group. Consequently, GE limited the production of isoprostanes compared to the placebo at D30 (1.24+/-0.12 vs 1.26+/-0.13 ng·mg-1 creatinine; p < 0.05. GE administration, compared to the placebo at D30, reduced the plasmatic creatine phosphokinase concentration (CPK, 695.7+/-177.0 vs 480.0+/-81.1 IU·L-1, p = 0.1 and increased hemoglobin levels (Hb, 14.5+/-0.2 vs 14

  14. Direct and indirect relationships of physical fitness, weight status, and learning duration to academic performance in Japanese schoolchildren.

    Science.gov (United States)

    Ishihara, Toru; Morita, Noriteru; Nakajima, Toshihiro; Okita, Koichi; Yamatsu, Koji; Sagawa, Masato

    2018-03-01

    The purpose of this study was to determine, using structural equation modelling (SEM), the direct and indirect influence of daily behaviours (i.e. exercise/learning durations), weight status, and physical fitness on academic performance among seventh-grade schoolchildren, after controlling for socioeconomic status. We analysed cross-sectional data from 274 schoolchildren (159 males and 115 females; 12-13 years old). Academic performance was assessed using the total grade points in eight academic subjects. Physical fitness was evaluated using the total score of eight physical fitness tests and weight status using body mass index. The daily behaviours and socioeconomic status were assessed by the questionnaire. The SEM showed an adequate fit to the data (χ 2  = 0.684, p = .710, RMSEA = .000). Physical fitness and learning durations had direct effects on academic performance (β = .301, p academic performance via physical fitness. These findings suggest that, independent of socioeconomic status and learning durations, exercise habits and maintaining healthy weight status may indirectly contribute to academic success via better physical fitness in children.

  15. Growth and Physiological Performance of Aerobic and Lowland Rice as Affected by Water Stress at Selected Growth Stages

    Directory of Open Access Journals (Sweden)

    Nadzariah Kamarul Zaman

    2018-03-01

    Full Text Available Aerobic rice technology is still new in Malaysia, and information regarding MARDI Aerob 1 (MA1, the first local aerobic rice variety, is still lacking. Therefore, comparative studies were carried out to determine the physiological performance of aerobic rice variety MA1 and lowland rice variety MR253 under water stress given at the panicle initiation, flowering and ripening stages. This experiment was arranged in a randomized complete block design. Stomatal conductance (gs, chlorophyll a fluorescence (Fv/Fm, leaf relative water content (leaf RWC, and soil moisture content (SMC as well as yield component parameters such as panicle number, grain yield and 100-grain weight were measured. Results revealed that gs and leaf RWC for both varieties decreased with depletion of SMC. The correlation study between the physiological parameters and SMC indicated that Fv/Fm was not affected by water stress, regardless of varieties. The yield components (panicle number, grain yield and 100-grain weight for both varieties greatly decreased when water stress was imposed at the panicle initiation stage. This study showed that the panicle initiation period was the most sensitive stage to water stress that contributed to a substantial reduction in yield for both varieties. Under the aerobic condition (control, MR253 produced higher panicle number, 100-grain weight and yield than MA1. Although MR253 is bred for lowland, it is well adapted to aerobic condition.

  16. Achievement of VO2max criteria during a continuous graded exercise test and a verification stage performed by college athletes.

    Science.gov (United States)

    Mier, Constance M; Alexander, Ryan P; Mageean, Amanda L

    2012-10-01

    The purpose of this study was to determine the incidence of meeting specific VO2max criteria and to test the effectiveness of a VO2max verification stage in college athletes. Thirty-five subjects completed a continuous graded exercise test (GXT) to volitional exhaustion. The frequency of achieving various respiratory exchange ratio (RER) and age-predicted maximum heart rate (HRmax) criteria and a VO2 plateau within 2 and 2.2 ml·kg(-1)·min(-1) (active recovery, 10 subjects who did not demonstrate a plateau completed a verification stage performed at supramaximal intensity. From the GXT, the number of subjects meeting VO2max plateau was 5 (≤2 ml·kg(-1)·min(-1)) and 7 (≤2.2 ml·kg(-1)·min(-1)), RER criteria 34 (≥1.05), 32 (≥1.10), and 24 (≥1.15), HRmax criteria, 35 (athlete's ability to achieve VO2max plateau and certain RER and HR criteria. The use of a verification stage increases the frequency of VO2max achievement and may be an effective method to improve the accuracy of VO2max measurements in college athletes.

  17. Early-1990 status of performance assessment for the Waste Isolation Pilot Plant disposal system

    International Nuclear Information System (INIS)

    Bertram-Howery, S.G.; Swift, P.N.

    1991-07-01

    This paper summarizes the early-1990 status of the performance-assessment work being done to evaluate compliance of the Waste Isolation Pilot Plant with the U.S. Environmental Protection Agency regulation 40 CFR Part 191, Subpart B. This regulation sets environmental standards for radioactive waste disposal (Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes). As required by Subpart B, evaluations of compliance will include probabilistic numerical simulations of repository performance and qualitative judgments. Compliance appears uncertain only in the event of human intrusion into the repository after decommissioning. Issues affecting compliance following intrusion include properties of the plugs used to seal the intruding borehole, permeability and porosity of the waste, and possible pressurization of the repository by gas generated from the organic decomposition and corrosion of the waste and containers. Research is in progress to determine the probability of intrusion and to quantify parameter uncertainties needed to include these factors in simulations of repository performance. The Department of Energy (DOE) is following two strategies to assure compliance. First, passive marker systems will be designed and implemented to reduce the likelihood of intrusion and increase the likelihood that intruders will properly reseal the repository. Second, modifications to the form of the waste and the design of the repository to achieve acceptable performance if the intruding borehole is not adequately sealed will be designed. Goals include reductions in gas generation and waste permeability and porosity. Numerous modifications are technically possible. Work in progress will evaluate proposed modifications and recommend the most promising for further testing. The DOE is confident that compliance with Subpart B of 40 CFR 191 can be established using a combination of the two strategies

  18. Relations of imagery, creativity, and socioeconomic status with performance on a stock-market E-trading game.

    Science.gov (United States)

    Roberts, D S; MacDonald, B E

    2001-06-01

    The purpose of the present investigation was to examine how measures of imagery, creativity, and socioeconomic status relate to performance in a stock-market trading game. The 368 participants were students enrolled in an administration studies curriculum. A multiple regression analysis showed imaging scores to be a predictor of stock-trading performance as were creativity and socioeconomic status to a lesser extent. High imagers and high scorers on creativity and socioeconomic status made several times more profit with their portfolios. Results are discussed in terms of imagery having multiple repercussions on learning, e.g., memory and problem-solving. It is concluded that scores on imagery, creativity, and socioeconomic status, being weakly correlated, are interdependent and likely associated with personality traits shaped within a stimulating home or social environment.

  19. Noise performance of phase-insensitive multicasting in multi-stage parametric mixers.

    Science.gov (United States)

    Huynh, Christopher K; Tong, Zhi; Myslivets, Evgeny; Wiberg, Andreas O J; Adleman, James R; Zlatanovic, Sanja; Jacobs, Everett W; Radic, Stojan

    2013-01-14

    Noise properties of large-count spectral multicasting in a phase-insensitive parametric mixer were investigated. Scalable multicasting was achieved using two-tone continuous-wave seeded mixers capable of generating more than 20 frequency non-degenerate copies. The mixer was constructed using a multistage architecture to simultaneously manage high Figure-of-Merit frequency generation and suppress noise generation. The performance was characterized by measuring the conversion efficiency and noise figure of all signal copies. Minimum noise figure of 8.09dB was measured. Experimental findings confirm that noise of the multicasted signal does not grow linearly with copy count and that it can be suppressed below this limit.

  20. Performance testing of self-powered detector signal converters at Dukovany nuclear power plant - stage 1

    International Nuclear Information System (INIS)

    Erben, O.; Hajek, P.; Zerola, L.; Karsulin, M.

    1990-11-01

    The converters were manufactured at the Institute of Nuclear Research, Rez. Dynamic functions of the converters were tested during the start-up of reactor unit 4, Dukovany nuclear power plant, and their stability during its normal operation. The results and evaluation of the measurements show a good performance of converters. They have a low offset, good stability and the values of current are in a good agreement with the values obtained using other methods. The values of insulation resistance are in a good agreement with the values obtained manually using the method of additional resistance. These converters are planned to be used in the upgraded in-service inspection system in WWER-440 nuclear power plants. (Z.S.) 9 tabs., 22 figs., 1 ref

  1. Impact of Multi-Micronutrient-Fortified Rice on Micronutrient Status, Health, and Cognitive Performance in Schoolchildren in Cambodia

    DEFF Research Database (Denmark)

    Khov, Kuong

    ferritin concentrations Food fortification...... with multiple micronutrients has the potential to improve micronutrient status, growth and cognitive performance, and reduce morbidity incidence in developing countries. In Cambodia, rice is a staple food, and therefore fortified rice with multiple micronutrients could be a promising strategy to reduce...... the prevalence of micronutrient deficiencies. However, few studies have investigated the impact of fortified rice on micronutrient status, health and cognitive development in school-age children. Therefore, the aim of this PhD study is to evaluate the impact of fortified rice on nutritional status, health...

  2. Exercise Performance and 22q11.2 Deletion Status Affect Quality of Life in Tetralogy of Fallot.

    Science.gov (United States)

    Goldmuntz, Elizabeth; Cassedy, Amy; Mercer-Rosa, Laura; Fogel, Mark A; Paridon, Stephen M; Marino, Bradley S

    2017-10-01

    To identify mediators of health status and quality of life (QOL) in children and adolescents aged 8-18 years old following surgical repair for tetralogy of Fallot (TOF), including resource use, exercise performance, and 22q11.2 deletion status. We performed a corollary study to a cross-sectional analysis of subjects following repair for TOF that completed cardiac magnetic resonance imaging, cardiopulmonary exercise tests, and instruments assessing health status and QOL. General linear models were used to test for mediation. A total of 29 of 151 (19%) patients carried a 22q11.2 deletion. Parents of children with a deletion compared with those without a deletion reported worse physical and psychosocial functioning on the Child Health Questionnaire. The patients with a 22q11.2 deletion and their parents reported lower total and Disease Impact scores compared with the group without a deletion on the Pediatric Cardiac Quality of Life Inventory. Medical care use negatively correlated with measures of health status/QOL. Greater maximum work correlated with better patient health status and QOL, regardless of deletion status. Exercise performance mediated the association between deletion status and parent-reported outcomes (unstandardized effects ranging from 2.4 to 4.2) and patient-reported Disease Impact (0.99; 95% CI 0.02-2.70). Children and adolescents following repair for TOF seem to suffer significant challenges to their health status and QOL, which is amplified markedly in the context of the 22q11.2 deletion syndrome, and related to exercise performance. Copyright © 2017. Published by Elsevier Inc.

  3. An experimental study of adolescent sleep restriction during a simulated school week: changes in phase, sleep staging, performance and sleepiness.

    Science.gov (United States)

    Agostini, Alex; Carskadon, Mary A; Dorrian, Jillian; Coussens, Scott; Short, Michelle A

    2017-04-01

    This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours). Saliva was collected in dim light on the first and last sleep restriction nights to measure melatonin onset phase. Sleep was recorded polysomnographically, and the Psychomotor Vigilance Task (PVT) and Karolinska Sleepiness Scale were undertaken 3-hourly while awake. Average phase delay measured by melatonin was 3 h (SD = 50 min). Compared to baseline, sleep during the restriction period contained a smaller percentage of Stages 1 and 2 and rapid eye movement (REM) and a greater percentage of Stage 4. PVT lapses increased significantly during sleep restriction and did not return to baseline levels during recovery. Subjective sleepiness showed a similar pattern during restriction, but returned to baseline levels during recovery. Results suggest that sustained attention in adolescents is affected negatively by sleep restriction, particularly in the early morning, and that a weekend of recovery sleep is insufficient to restore performance. The discrepancy between sleepiness ratings and performance may indicate a lack of perception of this residual impairment. © 2016 European Sleep Research Society.

  4. Role of medicinal plants on growth performance and immune status in fish.

    Science.gov (United States)

    Awad, Elham; Awaad, Amani

    2017-08-01

    Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases. This article describes a wide range of medicinal plants such as herbs, seeds, and spices with different forms such as crude, extracts, mixed and active compounds, used as immunostimulants and resulting in a marked enhancement in the immune system of fish to prevent and control microbial diseases. Moreover, different activity was recorded from plant parts like seeds, roots, flowers and leaves. The mode of action of medicinal plants was stimulation of the cellular and humoral immune response which was monitored through elevation in immune parameters. Various levels of immune stimulation have been shown by medicinal plants at different concentrations through injection or immersion or oral administration. However, it is critically important to determine the optimal dose to enhance the immune system of fish and avoid the risk of immunosuppression. Some medicinal plants have been used to replace the protein in fishmeal as a cheap source of protein and proved to be efficient in this respect. Medicinal plants can act as a growth promoter and immunomodulator at the same time. Further investigations should be carried out to examine the influence of those plants on fish health (including physiological and histological parameters) as a preliminary step for use in large scale in aquaculture. The current review describes the role of medicinal plants and their derivatives on innate and adaptive immune status as well as growth

  5. Diagnostic accuracy of computed tomography and magnetic resonance imaging obtained after neoadjuvant chemoradiotherapy in predicting the local tumor stage and circumferential resection margin status of rectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Hoon; Kim, Young Hoon; Lee, Yoon Jin; Lee, Kyoung Ho; Kang, Sung Bum; Kim, Duck Woo; Kim, Jae Hyun; Kim, Jae Sung; Lee, Hye Seung [Dept. of Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam (Korea, Republic of); Lee, Sang Min [Dept. of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of)

    2014-02-15

    To measure the diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) obtained after neoadjuvant chemoradiotherapy (CRT) in patients with rectal cancer for a prediction of the local tumor stage and circumferential resection margin (CRM). Two independent radiologists reviewed CT and MRI obtained after neoadjuvant CRT. The accuracy of the local tumor staging and the diagnostic performance for the prediction of CRM involvement were calculated. The agreement between the measurements of the distance to potential CRM on both imaging modalities and the histopathology findings was assessed using Bland-Altman plots. 57 patients (mean age, 59.2 years; 24 females) were included. The accuracy of T and N staging were 43.9% (95% confidence interval, 30.8-57.7%) and 77.2% (64.2-87.3%) on CT and 63.2% (49.4-75.6%) and 77.2% (64.2-87.3%) on MRI for Observer 1. The accuracy of T and N staging were 54.4% (40.7-67.7%) and 77.2% (64.2-87.3%) on CT and 68.4% (54.7-80.1%) and 80.7% (68.1-90.0%) on MRI for Observer 2. Sensitivity and specificity on CRM involvement were 83.3% (43.7-97.0%) and 88.2% (76.6-94.5%) on CT and 100% (61.0-100%) and 90.2% (79.0-95.7%) on MRI for Observer 1. Sensitivity and specificity on CRM involvement were 66.7% (30.0-90.3%) and 88.2% (76.7-94.5%) on CT and 100% (61.0-100%) and 90.2% (79.0-95.7%) on MRI for Observer 2. Bland-Altman plots showed wide discrepancies between measurements of the distance to CRM on each CT and MRI and those on histopathology findings. CT and MRI showed limited performance in predicting the local tumor staging and CRM involvement in patients with neoadjuvant CRT although MRI tended to show a better performance than CT.

  6. Dietary Supplementation of Phoenix dactylifera Seeds Enhances Performance, Immune Response, and Antioxidant Status in Broilers

    Directory of Open Access Journals (Sweden)

    Ali H. El-Far

    2016-01-01

    Full Text Available The date palm (Phoenix dactylifera seeds were utilized in some traditional medical remedies and have been investigated for their possible health benefits. This proposed study wanted to assess the effect of date palm seeds (DPS dietary supplementation in comparison to mannan-oligosaccharides (Bio-Mos® and β-glucan over antioxidant and immunity events that have effect on growth and carcass performances of broilers. An aggregate of 180, one-day-old, chicks were raised in the wire-floored cages and allotted into control, Bio-Mos (0.1%  Bio-Mos, β-glucan (0.1%  β-glucan, DPS2 (2% date crushed seeds, DPS4 (4% date crushed seeds, and DPS6 (6% date crushed seeds groups. Broilers in DPS2 and DPS4 groups showed significant variations (P<0.05 in relative growth rate (RGR, feed conversion ratio (FCR, and efficiency of energy utilization in comparison to control group. Moreover, all DPS fed groups showed significant increases (P<0.05 in serum reduced glutathione (GSH values. Meanwhile, both serum interferon-gamma (IFN-γ and interleukin-2 (IL-2 levels were significantly increased (P<0.05 in DPS2. Consequently, obtained data revealed a substantial enhancement of performance, immunity, and antioxidant status by DPS supplementation in broiler that might be related to the antioxidant and immune-stimulant constituents of P. dactylifera seeds.

  7. Evaluating the impact of public subsidies on a firm’s performance: a two-stage quasi-experimental approach

    Directory of Open Access Journals (Sweden)

    Mauro Mediavilla

    2009-11-01

    Full Text Available In this paper we evaluate the effectiveness of regional R&D public programs in Catalonia (Spain with a two-stage procedure. Firstly, we compare the performance of publicly subsidised companies (treated with that of similar, but unsubsidised companies (non-treated. We use the Propensity Score Matching (PSM methodology to construct a control group which, with regard to its observable characteristics, is as similar as possible to the treated group, and that allows us to identify firms which maintain the same propensity to receive public subsidies. Secondly, and once a valid comparison group has been established, we compare the respective performance of each firm using regression techniques. As a result, we find that recipient firms, on average, seem to increase their value added as a direct result of public subsidy programs.

  8. M & V Shootout: Setting the Stage For Testing the Performance of New Energy Baseline

    Energy Technology Data Exchange (ETDEWEB)

    Touzani, Samir; Custodio, Claudine; Sohn, Michael; Fernandes, Samuel; Granderson, Jessica; Jump, David; Taylor, Cody

    2015-07-01

    Trustworthy savings calculations are critical to convincing investors in energy efficiency projects of the benefit and cost-effectiveness of such investments and their ability to replace or defer supply-side capital investments. However, today’s methods for measurement and verification (M&V) of energy savings constitute a significant portion of the total costs of efficiency projects. They also require time-consuming data acquisition and often do not deliver results until years after the program period has ended. A spectrum of savings calculation approaches are used, with some relying more heavily on measured data and others relying more heavily on estimated or modeled data, or stipulated information. The rising availability of “smart” meters, combined with new analytical approaches to quantifying savings, has opened the door to conducting M&V more quickly and at lower cost, with comparable or improved accuracy. Energy management and information systems (EMIS) technologies, not only enable significant site energy savings, but are also beginning to offer M&V capabilities. This paper expands recent analyses of public-domain, whole-building M&V methods, focusing on more novel baseline modeling approaches that leverage interval meter data. We detail a testing procedure and metrics to assess the performance of these new approaches using a large test dataset. We also provide conclusions regarding the accuracy, cost, and time trade-offs between more traditional M&V and these emerging streamlined methods. Finally, we discuss the potential evolution of M&V to better support the energy efficiency industry through low-cost approaches, and the long-term agenda for validation of building energy analytics.

  9. The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity

    Directory of Open Access Journals (Sweden)

    Hiromi Tanaka

    2014-10-01

    Full Text Available Defects in telomere maintenance can result in telomere fusions that likely play a causative role in carcinogenesis by promoting genomic instability. However, this proposition remains to be fully understood in human colon carcinogenesis. In the present study, the temporal sequence of telomere dysfunction dynamics was delineated by analyzing telomere fusion, telomere length, telomerase activity, hotspot mutations in KRAS or BRAF, and TP53 of tissue samples obtained from 18 colon cancer patients. Our results revealed that both the deficiency of p53 and the shortening of mean telomere length were not necessary for producing telomere fusions in colon tissue. In five cases, telomere fusion was observed even in tissue adjacent to cancerous lesions, suggesting that genomic instability is initiated in pathologically non-cancerous lesions. The extent of mean telomere attrition increased with lymph node invasiveness of tumors, implying that mean telomere shortening correlates with colon cancer progression. Telomerase activity was relatively higher in most cancer tissues containing mutation(s in KRAS or BRAF and/or TP53 compared to those without these hotspot mutations, suggesting that telomerase could become fully active at the late stage of colon cancer development. Interestingly, the majority of telomere fusion junctions in colon cancer appeared to be a chromatid-type containing chromosome 7q or 12q. In sum, this meticulous correlative study not only highlights the concept that telomere fusion is present in the early stages of cancer regardless of TP53/KRAS mutation status, mean telomere length, and telomerase activity, but also provides additional insights targeting key telomere fusion junctions which may have significant implications for colon cancer diagnoses.

  10. Association between masticatory performance and anthropometric measurements and nutritional status in the elderly.

    Science.gov (United States)

    Okada, Kiwako; Enoki, Hiromi; Izawa, Sachiko; Iguchi, Akihisa; Kuzuya, Masafumi

    2010-01-01

    The association between chewing ability and physical constitution and nutritional status remains uncertain in the elderly. We examined the relationships between chewing ability and anthropometric measurements or nutritional status in the elderly. A total of 200 subjects (78 men and 122 women; mean age +/- standard deviation, 76.6 +/- 7.1) were enrolled from geriatric clinical settings. Chewing ability was evaluated by color-changeable chewing gum. Bodyweight, body mass index, mid-upper-arm circumference (MAC), and triceps skinfold, grip strength, serum albumin, physical and cognitive functions, depressive status, and dental status were determined. Correlations were found between chewing ability and bodyweight, MAC, dental status, physical and cognitive functions, and depressive status after adjusting for age and sex. The concentrations of serum albumin were well-correlated with chewing ability and anthropometric measurements. Stepwise linear regression analyses revealed that the masticatory cycle, dental status, bodyweight and MAC are predictors of chewing ability, and that age, chewing ability, grip strength and sex are predictors of serum albumin concentrations. Chewing ability is associated with not only oral health status but also the physical constitution of the elderly. In addition, chewing ability may add to the regulation of the nutritional status in the elderly.

  11. Status and performance of the CALorimetric Electron Telescope (CALET) on the International Space Station

    Energy Technology Data Exchange (ETDEWEB)

    Adriani, O. [University of Florence, IFAC (CNR) and INFN (Italy); Akaike, Y. [ICRR, University of Tokyo (Japan); Asaoka, Y. [Waseda University (Japan); Asano, K. [Tokyo Institute of Technology (Japan); Bagliesi, M.G.; Bigongiari, G. [University of Siena and INFN (Italy); Binns, W.R. [Washington University-St. Louis (United States); Bongi, M. [University of Florence, IFAC (CNR) and INFN (Italy); Buckley, J.H. [Washington University-St. Louis (United States); Cassese, A.; Castellini, G. [University of Florence, IFAC (CNR) and INFN (Italy); Cherry, M.L. [Louisiana State University (United States); Collazuol, G. [University of Padova and INFN (Italy); Ebisawa, K. [JAXA/ISAS (Japan); Di Felice, V. [University of Rome Tor Vergata and INFN (Italy); Fuke, H. [JAXA/ISAS (Japan); Guzik, T.G. [Louisiana State University (United States); Hams, T. [CRESST/NASA/GSFC and University of Maryland (United States); Hasebe, N. [Waseda University (Japan); Hareyama, M. [St. Marianna University School of Medicine (Japan); and others

    2014-11-15

    The CALorimetric Electron Telescope (CALET) space experiment, currently under development by Japan in collaboration with Italy and the United States, will measure the flux of cosmic-ray electrons (including positrons) to 20 TeV, gamma rays to 10 TeV and nuclei with Z=1 to 40 up to 1,000 TeV during a two-year mission on the International Space Station (ISS), extendable to five years. These measurements are essential to search for dark matter signatures, investigate the mechanism of cosmic-ray acceleration and propagation in the Galaxy and discover possible astrophysical sources of high-energy electrons nearby the Earth. The instrument consists of two layers of segmented plastic scintillators for the cosmic-ray charge identification (CHD), a 3 radiation length thick tungsten-scintillating fiber imaging calorimeter (IMC) and a 27 radiation length thick lead-tungstate calorimeter (TASC). CALET has sufficient depth, imaging capabilities and excellent energy resolution to allow for a clear separation between hadrons and electrons and between charged particles and gamma rays. The instrument will be launched to the ISS within 2014 Japanese Fiscal Year (by the end of March 2015) and installed on the Japanese Experiment Module-Exposed Facility (JEM-EF). In this paper, we will review the status and main science goals of the mission and describe the instrument configuration and performance.

  12. White matter disruption at the prodromal stage of Alzheimer's disease: Relationships with hippocampal atrophy and episodic memory performance

    Directory of Open Access Journals (Sweden)

    Florence Rémy

    2015-01-01

    Full Text Available White matter tract alterations have been consistently described in Alzheimer's disease (AD. In particular, limbic fronto-temporal connections, which are critical to episodic memory function, may degenerate early in the course of the disease. However the relation between white matter tract degeneration, hippocampal atrophy and episodic memory impairment at the earliest stages of AD is still unclear. In this magnetic resonance imaging study, white matter integrity and hippocampal volumes were evaluated in patients with amnestic mild cognitive impairment due to AD (Albert et al., 2011 (n = 22 and healthy controls (n = 15. Performance in various episodic memory tasks was also evaluated in each participant. Relative to controls, patients showed a significant reduction of white matter fractional anisotropy (FA and increase of radial diffusivity (RD in the bilateral uncinate fasciculus, parahippocampal cingulum and fornix. Within the patient group, significant intra-hemispheric correlations were notably found between hippocampal grey matter volume and FA in the uncinate fasciculus, suggesting a relationship between atrophy and disconnection of the hippocampus. Moreover, episodic recognition scores were related with uncinate fasciculus FA across patients. These results indicate that fronto-hippocampal connectivity is reduced from the earliest pre-demential stages of AD. Disruption of fronto-hippocampal connections may occur progressively, in parallel with hippocampal atrophy, and may specifically contribute to early initial impairment in episodic memory.

  13. Effects of vitamin C supplementation on performance, iron status and immune function of weaned piglets.

    Science.gov (United States)

    Zhao, Junmei; Li, Defa; Piao, Xiangshu; Yang, Wenjun; Wang, Fenglai

    2002-02-01

    Two experiments were conducted to evaluate the effects of vitamin C supplementation on performance, iron status and immune function of pigs during the 21-day post-weaning period. In experiment one, 48 crossbred pigs (Chester White x Large White x Yorkshire), weaned at 30 days of age and weighing 7.7 +/- 0.9 kg, were allotted to diets containing either 0 or 300 mg/kg vitamin C. In experiment two, 96 crossbred pigs (Chester White x Large White x Yorkshire), weaned at 20 +/- 2 days and weighing 7.1 +/- 0.5 kg, were allotted to diets containing 0.75 or 300 mg/kg vitamin C. Six replicate pens were assigned to each treatment in experiment one while experiment two had eight replicates. All pens housed two barrows and two gilts. In both experiments, no improvement (P > 0.05) in growth rate, feed intake or feed conversion was observed as a result of vitamin C supplementation. Plasma iron concentration increased (P immunity (P > 0.05). In trial 2, the plasma levels of the immunoglobulin IgG showed a linear (P = 0.07) increase with increasing levels of vitamin C and the same trend was noted in trial 1. Antibody titers to bovine serum albumin also tended to increase in both trials but the increases were not statistically significant. In conclusion, the overall results of these experiments indicate that weanling pig performance is not improved as a result of vitamin C supplementation. Whether or not vitamin C plays a role in stimulating humoral immune function in pigs requires further study since the results of our experiments do not completely rule out the possibility that such a role exists.

  14. Staging and Performing Dialogue

    DEFF Research Database (Denmark)

    Knox, Jeanette Bresson Ladegaard

    2015-01-01

    A Socratic Dialogue Group (SDG) harbors human drama in the stories and reflections of its participants.Through the use of a theater metaphor, I theoretically expand the method and practical action of SDG, whereby a distinctive approach is developed that emphasizes the art and craftsmanship involved...... of an individual life to the larger-scale human stories of moral tragedies and the empowering resilience that we see depicted in great plays. In 2012-2013, I conducted three SDGs in connection with a research project involving seventeen rehabilitating cancer patients. In this article, I use these dialogues...

  15. The preface as stage: the theatrical trope and the performance of authorial identities in the nineteenth century

    Directory of Open Access Journals (Sweden)

    Geraldo Magela Cáffaro

    2017-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2017v70n1p265 This essay explores references to the theatre in prefaces by Charles Dickens, Nathaniel Hawthorne, and Henry James. Particular emphasis is given to the way these authors employ figures such as stage manager and dramatist to reach their audiences and project authorial images. The figures in question are historicized and discussed in light of the concepts identified by the terms performative and theatre of images and the argument proposed is that references to the theatre reveal tensions between self-display and self-concealment, as well as between the assertion of authority and its subversion and fragmentation in nineteenth-century prefatory writing.

  16. Predicting off-design range and performance of refrigeration cycle with two-stage centrifugal compressor and flash intercooler

    Energy Technology Data Exchange (ETDEWEB)

    Turunen-Saaresti, Teemu; Roeyttae, Pekka; Honkatukia, Juha; Backman, Jari [Lappeenranta University of Technology, Institute of Energy Technology, Laboratory of Fluid Dynamics, P.O. Box 20, 53851 Lappeenranta (Finland)

    2010-09-15

    A modern refrigeration process requires constant control to provide required cooling for the user. To properly and economically accommodate this need, a wide operation range of the compressor is necessary. Therefore, it is of interest to investigate the off-design operation of a cooling cycle and compressor. The refrigeration cycle equipped with a two-stage centrifugal compressor and a flash intercooler is studied. The compressor operation maps are generated with two different design codes and the operation values of the compressors are interpolated from the compressor maps in the simulation of the entire cooling cycle. Based on the previous studies of the utilised refrigeration cycle, R245fa is selected as coolant. The aim of this study is to demonstrate the control capacity of the centrifugal compressor and the performance of the cooling loop in off-design conditions. This configuration provides better and wider control over the cooling range than the traditional on-off control of displacement compressors. (author)

  17. Performance estimates for space shuttle vehicles using a hydrogen or a methane fueled turboramjet powered first stage

    Science.gov (United States)

    Knip, G., Jr.; Eisenberg, J. D.

    1972-01-01

    Two- and three-stage (second stage expendable) shuttle vehicles, both having a hydrogen-fueled, turboramjet-powered first stage, are compared with a two-stage, VTOHL, all-rocket shuttle in terms of payload fraction, inert weight, development cost, operating cost, and total cost. All of the vehicles place 22,680 kilograms of payload into a 500-kilometer orbit. The upper stage(s) uses hydrogen-oxygen rockets. The effect on payload fraction and vehicle inert weight of methane and methane-FLOX as a fuel-propellant combination for the three-stage vehicle is indicated. Compared with a rocket first stage for a two-stage shuttle, an airbreathing first stage results in a higher payload fraction and a lower operating cost, but a higher total cost. The effect on cost of program size and first-stage flyback is indicated. The addition of an expendable rocket second stage (three-stage vehicle) improves the payload fraction but is unattractive economically.

  18. Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth

    DEFF Research Database (Denmark)

    Braga, M M; Ekstrand, K R; Martignon, S

    2010-01-01

    This study aimed to compare the clinical performance of two sets of visual scoring criteria for detecting caries severity and assessing caries activity status in occlusal surfaces. Two visual scoring systems--the Nyvad criteria (NY) and the ICDAS-II including an adjunct system for lesion activity...

  19. The impact of physical performance and cognitive status on subsequent ADL disability in low-functioning older adults

    NARCIS (Netherlands)

    Kempen, GIJM; Ormel, J

    Objectives. The purpose of this study was to examine the independent contributions of physical performance and cognitive status to subsequent levels of ADL disability in low-functioning non-institutionalized older adults. Methods. A prospective cohort study included 416 women and 141 men 57 years of

  20. Family Status, Family Constellation, and Home Environmental Variables as Predictors of Cognitive Performance of Mexican American Children.

    Science.gov (United States)

    Valencia, Richard R.; And Others

    1985-01-01

    The relative contributions of family status variables, a family constellation variable, and the Henderson Environmental Learning Process Scale to prediction of cognitive performance among Mexican American preschool children from low-income backgrounds were examined. Implications of including background variables in research on relations between…

  1. A Robust High-Performance GPS L1 Receiver with Single-stage Quadrature Redio-Frequency Circuit

    Science.gov (United States)

    Liu, Jianghua; Xu, Weilin; Wan, Qinq; Liu, Tianci

    2018-03-01

    A low power current reuse single-stage quadrature raido-frequency part (SQRF) is proposed for GPS L1 receiver in 180nm CMOS process. The proposed circuit consists of LNA, Mixer, QVCO, is called the QLMV cell. A two blocks stacked topology is adopted in this design. The parallel QVCO and mixer placed on the top forms the upper stacked block, and the LNA placed on the bottom forms the other stacked block. The two blocks share the current and achieve low power performance. To improve the stability, a float current source is proposed. The float current isolated the local oscillation signal and the input RF signal, which bring the whole circuit robust high-performance. The result shows conversion gain is 34 dB, noise figure is three dB, the phase noise is -110 dBc/Hz at 1MHz and IIP3 is -20 dBm. The proposed circuit dissipated 1.7mW with 1 V supply voltage.

  2. The influence of whole-corn feeding method during the finishing stage on the performance of overfed mule ducks.

    Science.gov (United States)

    Arroyo, J; Lavigne, F; Fortun-Lamothe, L

    2017-09-01

    The aim of this trial was to compare 2 feeding systems based on whole corn, a loose-mix and a free-choice feeding system, during the finishing stage on the performance of ducks. Five hundred sixteen day-old male mule ducks (Muscovy drake × Pekin duck) were divided into 3 groups that differed in the presentation of the diet they received between 58 and 88 d of age: a complete pelleted diet (Control (CON) group; AMEn 12.1 MJ/kg, CP 15.0%) containing 500 g of corn per kg; or whole corn (AMEn 13.9 MJ/kg, CP 7.3%) and protein-rich pellets (AMEn 10.3 MJ/kg, CP 22.7%) in equal quantities mixed in the same feeders (loose-mix feeding [LMF] group) or in 2 separate feeders (free-choice feeding [FCF] group). From 89 to 99 d, 72 birds/group were overfed with a mixture containing mainly corn and water and then slaughtered to determine the weight and commercial value of the fatty liver. Feed intake was measured daily. Body weight (BW) was measured at 58, 88, and 99 d of age. From 58 to 88 d, total feed intake of the FCF group was +7% and +9% (+558 g and +672 g) higher than in the groups CON and LMF, respectively (P = 0.005). At 88 d, the BW was higher in the CON group than in the FCF group (4,959 vs. 4,778 g, P group being intermediate (4,874 g). During the experimental stage, the feed conversion ratio was higher in the FCF group than in the 2 others (+32%, P = 0.024), but the energy intake was similar between the 3 groups (92.6 MJ/duck, P = 0.353).After overfeeding (99 d), the BW (6,593 g), weight (642 g), and commercial grading of fatty liver were similar (P > 0.05) in the 3 groups. The present results suggest that loose-mix feeding during the finishing stage using whole corn is a solution for reducing feed cost. © 2017 Poultry Science Association Inc.

  3. Upper urinary tract stone disease in patients with poor performance status: active stone removal or conservative management?

    Science.gov (United States)

    Yamashita, Shimpei; Kohjimoto, Yasuo; Hirabayashi, Yasuo; Iguchi, Takashi; Iba, Akinori; Higuchi, Masatoshi; Koike, Hiroyuki; Wakamiya, Takahito; Nishizawa, Satoshi; Hara, Isao

    2017-11-16

    It remains controversial as to whether active stone removal should be performed in patients with poor performance status because of their short life expectancy and perioperative risks. Our objectives were to evaluate treatment outcomes of active stone removal in patients with poor performance status and to compare life prognosis with those managed conservatively. We retrospectively reviewed 74 patients with Eastern Cooperative Oncology Group performance status 3 or 4 treated for upper urinary tract calculi at our four hospitals between January 2009 and March 2016. Patients were classified into either surgical treatment group or conservative management group based on the presence of active stone removal. Stone-free rate and perioperative complications in surgical treatment group were reviewed. In addition, we compared overall survival and stone-specific survival between the two groups. Cox proportional hazards analysis was performed to investigate predictors of overall survival and stone-specific survival. Fifty-two patients (70.3%) underwent active stone removal (surgical treatment group) by extracorporeal shock wave lithotripsy (n = 6), ureteroscopy (n = 39), percutaneous nephrolithotomy (n = 6) or nephrectomy (n = 1). The overall stone-free rate was 78.8% and perioperative complication was observed in nine patients (17.3%). Conservative treatment was undergone by 22 patients (29.7%) (conservative management group). Two-year overall survival rates in surgical treatment and conservative management groups were 88.0% and 38.4%, respectively (p performance status could be performed safely and effectively. Compared to conservative management, surgical stone treatment achieved longer overall survival and stone-specific survival.

  4. Imaging characteristics of stage I non-small cell lung cancer on CT and FDG-PER; Relationship with epidermal growth factor receptor protein expression status and survival

    International Nuclear Information System (INIS)

    Lee, Youkyung; Lee, Hyun Ju; Kim, Young Tae; Kang, Chang Hyun; Goo, Jin Mo; Park, Chang Min; Paeng, Jin Chul; Chung, Doo Hyun; Jeon, Yoon Kyung

    2013-01-01

    To identify CT and FDG-PET features associated with epidermal growth factor receptor (EGFR) protein overexpression, and to evaluate whether imaging features and EGFR-overexpression can help predict clinical outcome. In 214 patients (M : F = 129 : 85; mean age, 63.2) who underwent curative resection of stage I non-small cell lung cancer, EGFR protein expression status was determined through immunohistochemical analysis. Imaging characteristics on CT and FDG-PET was assessed in relation to EGFR-overexpression. Imaging features and EGFR-overexpression were also evaluated for clinical outcome by using the Cox proportional hazards model. EGFR-overexpression was found in 51 patients (23.8%). It was significantly more frequent in tumors with an SUVmax > 5.0 (p 2.43 cm (p 5.0 (OR, 3.113; 95% CI, 1.375-7.049; p = 0.006) and diameter > 2.43 cm (OR, 2.799; 95% CI, 1.285-6.095; p = 0.010) were independent predictors of EGFR overexpression. Multivariate analysis showed that SUVmax > 4.0 (hazard ratio, 10.660; 95% CI, 1.370-82.966; p = 0.024), and the presence of cavitation within a tumor (hazard ratio, 3.122; 95% CI, 1.143-8.532; p = 0.026) were factors associated with poor prognosis. EGFR-overexpression is associated with high SUVmax, large tumor diameter, and small GGO proportion. CT and FDG-PET findings, which are closely related to EGFR overexpression, can be valuable in the prediction of clinical outcome.

  5. A Review on the Role of Chromium Supplementation in Ruminant Nutrition-Effects on Productive Performance, Blood Metabolites, Antioxidant Status, and Immunocompetence.

    Science.gov (United States)

    Lashkari, Saman; Habibian, Mahmood; Jensen, Søren Krogh

    2018-03-28

    With the increase in the global herd, the use of metabolic modifiers has become an important area for many researchers looking for a supraphysiological diet to improve production parameters. For improving the performance of high yielding cows, the optimal balance of all nutrients including microminerals is important. Chromium (Cr) is one of the important micronutrients which plays an important role in metabolism of ruminants. Experimental studies have found that Cr could change performance, immune responses, glucose and fatty acid metabolism, and antioxidant status in dairy cows. In some studies, Cr supplementation improved dry matter intake, milk production, and milk composition of dairy cows in the early, mid, or late stage of lactation. Also, in some studies, performance of growing animal, immune response, and some blood parameters responded positively to Cr supplementation. In conclusion, the effects of Cr supplementation on performance of ruminants are inconsistent; however, its long-term effects on health, productivity, immune system, and antioxidant activity of ruminants still need to be investigated.

  6. Performance of a 13-Stage Development Compressor for the J40-WE-24 Engine at Equivalent Speeds from 30 to 112 Percent of Design

    Science.gov (United States)

    Hatch, James E.; Lucas, James G.; Finger, Harold B.

    1953-01-01

    The performance of a 13-stage development comressor for the J40-WE-24 engine has been determined at equivalent speeds from 30 to 112 percent of design. The design total-pressure ratio of 6.0 and the design weight flow of 164 pounds per second were not attained, An analysis was conducted to determine the reasons for the poor performance at the design and over-design speed. The analysis indicated that most of the difficulty could be attributed to the fact that the first stage was overcompromised to favor part-speed performance,

  7. Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR).

    Science.gov (United States)

    Chelliapan, S; Wilby, T; Sallis, P J; Yuzir, A

    2011-01-01

    Tylosin has been considered inhibiting COD removal in anaerobic digestion. In this study it is proven that this is not always the case. Accordingly, elevated concentrations of Tylosin (100-800mgL-1) could be tolerated by the anaerobic system. The influence of Tylosin concentrations on an up-flow anaerobic stage reactor (UASR) was assessed using additions of Tylosin phosphate concentrate. Results showed high efficiency for COD removal (average 93%) when Tylosin was present at concentrations ranging from 0 to 400 mg L-1. However, at Tylosin concentrations of 600 and 800 mg L-1 treatment efficiency declined to 85% and 75% removal respectively. The impact of Tylosin concentrations on archaeal activity were investigated and the analysis revealed that archaeal cells dominated the reactor, confirming that there was no detectable inhibition of the methanogens at Tylosin levels between 100 and 400mg L-1. Nevertheless, the investigation showed a slight reduction in the number of methanogens at Tylosin levels of 600 and 800 mg L-1. These results demonstrated that the methanogens were well adapted to Tylosin. It would not be expected that the process performance of the UASR would be affected, not even at a level well in excess of those appearing in real wastewater from a Tylosin production site.

  8. Aerodynamic performance of 0.4066-scale model of JT8D refan stage with S-duct inlet

    Science.gov (United States)

    Moore, R. D.; Kovich, G.; Lewis, G. W., Jr.

    1977-01-01

    A scale model of the JT8D refan stage was tested with a scale model of the S-duct inlet design for the refanned Boeing 727 center engine. Detailed survey data of pressures, temperatures, and flow angles were obtained over a range of flows at speeds from 70 to 97 percent of design speed. Two S-duct configurations were tested; one with a bellmouth inlet and the other with a flight lip inlet. The results indicated that the overall performance was essentially unaffected by the distortion generated by the S-duct inlet. The stall weight flow increased by less than 0.5 kg/sec (approximately 1.5% of design flow) with the S-duct inlet compared with that obtained with uniform flow. The detailed measurements indicated that the inlet guide vane (IGV) significantly reduced circumferential variations. For example, the flow angles ahead of the IGV were positive in the right half of the inlet and negative in the left half. Behind the IGV, the flow angles tended to be more uniform circumferentially.

  9. Influence of Maturation Stage on Agility Performance Gains After Plyometric Training: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Asadi, Abbas; Arazi, Hamid; Ramirez-Campillo, Rodrigo; Moran, Jason; Izquierdo, Mikel

    2017-09-01

    Asadi, A, Arazi, H, Ramirez-Campillo, R, Moran, J, and Izquierdo, M. Influence of maturation stage on agility performance gains after plyometric training: a systematic review and meta-analysis. J Strength Cond Res 31(9): 2609-2617, 2017-Although plyometric training (PT) improves change of direction (COD) ability, the influence of age on COD gains after PT is unclear. Therefore, the aim of this systematic review was to identify the age-related pattern of improvement in COD ability after PT in youths. A computerized search within 6 databases was performed, selecting studies based on specific inclusion criteria: experimental trials published in English-language journals, PT focused on the lower-body, COD ability measurements reported before and after training, and male participants aged 10 to 18 years. Sixteen articles with a total of 30 effect sizes (ESs) in the experimental groups and 13 ESs in the control groups were included. For the analyses, subjects were categorized into 3 age groups: 10-12.9 years of age (PRE), 13-15.9 years of age (MID), and 16-18 years of age (POST). Independent of age, PT improved COD ability in youths (ES = 0.86, time gains [TG = -0.61]). However, a tendency toward greater COD ability gains was observed in older subjects (MID, ES = 0.95; POST, ES = 0.99) compared with younger subjects (PRE, ES = 0.68). Pearson product-moment correlation (r) indicated that 2-weekly sessions of PT-induced meaningful COD ability gains (for ES, r = 0.436; for TG, r = -0.624). A positive relationship was found between training intensity and ES (r = 0.493). In conclusion, PT improves COD ability in youths, with meaningfully greater effects in older youths. Two PT sessions per week, with 1,400 moderate-intensity jumps for 7 weeks, seems to be an adequate dose.

  10. The effect of pre-exercise ingestion of corinthian currant on endurance performance and blood redox status.

    Science.gov (United States)

    Deli, Chariklia K; Poulios, Athanasios; Georgakouli, Kalliopi; Papanikolaou, Konstantinos; Papoutsis, Alexandros; Selemekou, Maria; Karathanos, Vaios T; Draganidis, Dimitris; Tsiokanos, Athanasios; Koutedakis, Yiannis; Fatouros, Ioannis G; Jamurtas, Athanasios Z

    2018-02-22

    The present study investigated the effect of Corinthian currant pre-exercise supplementation on metabolism, performance and blood redox status during, and after prolonged exercise. Eleven healthy participants (21-45y) performed a 90-min constant-intensity (60-70% VO 2max ) submaximal-trial, plus a time-trial (TT) to exhaustion (95% VO 2max ) after consuming an isocaloric (1.5g CHO/kg BM) amount of randomly assigned Corinthian currant or glucose-drink, or water (control). Blood was drawn at baseline, pre-exercise, 30min, 60min, 90min of submaximal-trial, post-TT, and 1h post-TT. Post-ingestion blood glucose (GLU) under Corinthian currant was higher compared with water, and similar compared with glucose-drink throughout the study. Respiratory quotient under Corinthian currant was similar with glucose-drink and higher than water throughout the submaximal trial. Accordingly, higher CHO and lower fat oxidation were observed under Corinthian currant compared with water. The TT performance was similar between Corinthian currant, glucose-drink and water. Redox status were similar under all three conditions. Reduced glutathione (GSH) declined while total antioxidant capacity (TAC) and uric acid increased during exercise. GSH and TAC returned to baseline, while uric acid remained increased the following 1h. Corinthian currant, although did not alter exercise-mediated redox status changes and performance, was equally effective to a glucose-drink in maintaining GLU levels during prolonged cycling.

  11. Application status and performance analysis of robot in nuclear power plants

    International Nuclear Information System (INIS)

    Liu Chengze; Yan Zhi; Deng Jingshan

    2012-01-01

    Application status of robot in nuclear power plants in some countries is summarized. The related robots include accident response robot, dismantling and cleaning robot, in-service inspection robot, special-purpose robot and so on. Finally, some key technologies such as the radiation-tolerance and reliability of the robot systems are analyzed in details. (authors)

  12. Performance of an iterative two-stage bayesian technique for population pharmacokinetic analysis of rich data sets

    NARCIS (Netherlands)

    Proost, Johannes H.; Eleveld, Douglas J.

    2006-01-01

    Purpose. To test the suitability of an Iterative Two-Stage Bayesian (ITSB) technique for population pharmacokinetic analysis of rich data sets, and to compare ITSB with Standard Two-Stage (STS) analysis and nonlinear Mixed Effect Modeling (MEM). Materials and Methods. Data from a clinical study with

  13. The association of self-reported sleep, weight status, and academic performance in fifth-grade students.

    Science.gov (United States)

    Stroebele, Nanette; McNally, Janise; Plog, Amy; Siegfried, Scott; Hill, James O

    2013-02-01

    To improve support and justification for health promotion efforts in schools, it is helpful to understand how students' health behaviors affect academic performance. Fifth-grade students completed an online school-administered health survey with questions regarding their eating behavior, physical activity, academic performance, and sleep patterns. Differences in health behaviors were examined by sex, self-reported weight status, and sufficient (≥9 hours) versus insufficient sleep. Logistic regression was used to determine the relationship between academic performance and the health behaviors. One third of the sample did not get the recommended amount of physical activity and more than half of the students watched television ≥ 2 hours/day. Self-reported overweight status was related to lower self-reported academic performance, fewer lunch and breakfast occasions, less physical activity, not meeting the recommendations for vegetable and soda consumption as well as hours of television watching. Sufficient sleep (≥9 hours/night) was associated with better grades, meeting the recommended hours of daily television watching and video game playing, being more physically active and increased breakfast and lunch frequency. Percentage of serving free/reduced lunch, soda consumption, breakfast frequency, amount of physical activity, and television watching were associated with academic performance. More positive health behaviors generally were associated with better academic performance. Promoting healthy behaviors in schools might improve not only students' health academic performance as well. © 2013, American School Health Association.

  14. Contrasting Trends of Smoking Cessation Status: Insights From the Stages of Change Theory Using Repeat Data From the Global Adult Tobacco Survey, Thailand (2009 and 2011) and Turkey (2008 and 2012).

    Science.gov (United States)

    Mbulo, Lazarous; Murty PhD, Komanduri S; Husain PhD, Muhammad Jami; Bashir Msc, Rizwan; Blutcher-Nelson BSc, Glenda; Benjakul PhD, Sarunya; Kengganpanich PhD, Mondha; Erguder Md PhD, Toker; Keskinkilic Md, Bekir; Polat Md, Sertac; Sinha Md PhD, Dhirendra N; Palipudi PhD, Krishna; Ahluwalia PhD, Indu B

    2017-06-01

    The World Health Organization recommends that smokers be offered help to quit. A better understanding of smokers' interest in and commitment to quitting could guide tobacco control efforts. We assessed temporal differences in stages of change toward quitting among smokers in Thailand and Turkey. Two waves (independent samples) of data from the Global Adult Tobacco Survey, a national household survey of adults aged 15 years or older, were assessed for Thailand (2009 and 2011) and Turkey (2008 and 2012). Current smokers were categorized into 3 stages of change based on their cessation status: precontemplation, contemplation, and preparation. Relative change in the proportion of smokers in each stage between waves 1 and 2 was computed for each country. Between waves, overall current tobacco smoking did not change in Thailand (23.7% to 24.0%) but declined in Turkey (31.2% to 27.1%; P change in preparation (6.5% to 8.5%; P = .097). Nearly two-thirds of smokers in Turkey and more than two-thirds in Thailand were in the precontemplation stage during the last survey wave assessed. The proportion of smokers in the preparation stage increased in Turkey but declined in Thailand. Identifying stages of cessation helps guide population-based targeted interventions to support smokers at varying stages of change toward quitting.

  15. Trends in peri-operative performance status following resection of high grade glioma and brain metastases: The impact on survival.

    Science.gov (United States)

    Patel, Chirag K; Vemaraju, Ravi; Glasbey, James; Shires, Joanne; Northmore, Tessa; Zaben, Malik; Hayhurst, Caroline

    2018-01-01

    Maximal surgical resection of high grade brain tumours is associated with improved overall survival (OS). It carries the risk of neurological deterioration leading to worsening performance status (PS), which may affect overall survival and preclude patients from adjuvant therapy. We aim to review the changes in performance status of patients undergoing resection of high grade tumours and metastases and the impact of changes on overall survival. A prospective study of the perioperative performance status of 75 patients who underwent primary resection of malignant primary brain tumour or solitary metastasis in a single centre. Data on patients' demographics, tumour histology and overall survival were also collected. WHO performance status was recorded pre-operatively and at intervals following surgery. Of the 75 patients (35 males, 40 females, median age 61 years at diagnosis), 50 had primary malignant brain tumours, 25 had metastasis. Although PS dropped at postoperative day 1 in 14 patients (18.7%), 28% improved by day 5 and there was significant improvement by day 14 (41%, p=0.02). The number of patients with PS 3 or worse changed from 4% pre-operatively (n=3) to 8% (n=6). Overall survival is better in those whose PS remained improved or unchanged at 2 weeks after surgery compared to those whose PS deteriorated; high grade glioma median survival 15.67 vs. 2.4 months (p=0.005) and metastasis median survival 8.53 vs.2.33 months (p=0.001). Our data demonstrates that although PS may deteriorate immediately after surgery, the majority of patients regain their baseline PS or improve by 2 weeks postoperatively; decisions on fitness for adjuvant treatment should therefore be delayed until then. In those patients whose PS declines following surgery overall survival is poor. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

  16. Effect of Cocoa Butter and Sunflower Oil Supplementation on Performance, Immunoglobulin, and Antioxidant Vitamin Status of Rats

    OpenAIRE

    Yıldırım, Ebru; Çınar, Miyase; Yalçınkaya, İlkay; Ekici, Hüsamettin; Atmaca, Nurgül; Güncüm, Enes

    2014-01-01

    This study investigated the effects of cocoa butter and sunflower oil alone and in combination on performance, some biochemical parameters, immunoglobulin, and antioxidant vitamin status in Wistar rats. Forty-eight male rats were assigned to four groups, consisting of 12 rats with 3 replicates. Control received balanced rat diet without oil, cocoa butter group received 3.5% cocoa butter, sunflower oil group received 3.5% sunflower oil, the last group received 1.75% sunflower oil + 1.75% cocoa...

  17. Influence of Marital Status on Attitude of Midwives towards OSCE and Their Performance in the Examination in Akwa Ibom and Cross River States, Nigeria

    Science.gov (United States)

    Duke, Emon Umoe; Mgbekem, Mary Achi; Nsemo, Alberta David; Ojong-Alacia, Mary Manyo; Nkwonta, Chigozie A.; Mobolaji-Olajide, O. M.

    2015-01-01

    This quantitative study investigated the influence of marital status on the midwives' attitude towards OSCE and how this affects their performance in the examination. Two hypotheses guided the study. HO 1 sort to find out if there exist a significant influence of marital status of midwives on their attitude towards OSCE as well as performance in…

  18. The Quadratic Relationship between Socioeconomic Status and Learning Performance in China by Multilevel Analysis: Implications for Policies to Foster Education Equity

    Science.gov (United States)

    Zhao, Ningning; Valcke, Martin; Desoete, Annemie; Verhaeghe, JeanPierre

    2012-01-01

    The purpose of the present study is to explore the relationship between family socioeconomic status and mathematics performance on the base of a multi-level analysis involving a large sample of Chinese primary school students. A weak relationship is found between socioeconomic status and performance in the Chinese context. The relationship does…

  19. Lipid profile and redox status in high performance rhythmic female teenagers gymnasts.

    Science.gov (United States)

    Guerra, A; Rego, C; Laires, M J; Castro, E M; Silva, D; Monteiro, C; Silva, Z; Lebre, E; Bicho, M

    2001-12-01

    The aim of the present study is to evaluate the lipid profile and some parameters of oxi-redox status in a group of teenage female athletes. All gymnasts of the Portuguese National Team of Rhythmic (n=20) were included in the study. A group of untrained healthy female adolescents, matched for age, was also included (n=28). Auxology, nutritional status and body composition were evaluated as well as biological parameters, dietary and training habits. Statistics included descriptive analysis, t-Student and Mann-Whitney for comparative study, and Pearson and Spearman correlations, according to variable distribution. Chronological age was 14.3+/-1.7 and 14.6+/-1,7 years, respectively for gymnasts and untrained adolescents. Gymnasts showed lower body mass index (pgymnasts, compared to untrained. Red blood cell's enzymes studied were higher for transmembrane NADH reductase of ferricyanide (TMR), (pgymnasts (76.3+/-20.3 microM/l versus 35+/-21.7 microM/l), (pgymnasts and untrained, between LDL-TBARS and LDL-cholesterol (r=0.674, pgymnasts. The authors conclude that the practice of intense physical exercise in rhythmic gymnasts induces a compromise of nutritional status and unbalanced food habits. The intensive exercise also induces not only a protective lipid profile, but also a higher lipid peroxidation. Further prospective studies are important to evaluate the influence of intensive training on atherosclerosis development.

  20. Prediction of 90 Day and Overall Survival after Chemoradiotherapy for Lung Cancer: Role of Performance Status and Body Composition.

    Science.gov (United States)

    Bowden, J C S; Williams, L J; Simms, A; Price, A; Campbell, S; Fallon, M T; Fearon, K C H

    2017-09-01

    If appropriate patients are to be selected for lung cancer treatment, an understanding of who is most at risk of adverse outcomes after treatment is needed. The aim of the present study was to identify predictive factors for 30 and 90 day mortality after chemoradiotherapy (CRT), and factors that were prognostic for overall survival. A retrospective cohort study of 194 patients with lung cancer who had undergone CRT in South East Scotland from 2008 to 2010 was undertaken. Gender, age, cancer characteristics, weight loss, body mass index (BMI), performance status (Eastern Cooperative Oncology Group; ECOG) and computed tomography-derived body composition variables were examined for prognostic significance using Cox's proportional hazards model and logistic regression. The median overall survival was 19 months (95% confidence interval 16.3, 21.7). Four of 194 patients died within 30 days of treatment completion, for which there were no independent predictive variables; 22/194 (11%) died within 90 days of treatment completion. BMI performance status ≥2 were independent predictors of death within 90 days of treatment completion (P = 0.001 and P = 0.004, respectively). Patients with either BMI performance status ≥ 2 had an odds ratio of death within 90 days of 5.97 (95% confidence interval 2.20, 16.19), rising to an odds ratio of 13.27 (1.70, 103.47) for patients with both BMI performance status ≥ 2. Patients with low muscle attenuation had significantly reduced overall survival (P = 0.004); individuals with low muscle attenuation had a median survival of 15.2 months (95% confidence interval 12.7, 17.7) compared with 23.0 months (95% confidence interval 18.3, 27.8) for those with high muscle attenuation, equating to a hazard ratio of death of 1.62 (95% confidence interval 1.17, 2.23, P = 0.003). Poor performance status, low BMI and low muscle attenuation identify patients at increased risk of premature death after CRT. Risk factors for adverse outcomes

  1. Influence of training status on high-intensity intermittent performance in response to β-alanine supplementation.

    Science.gov (United States)

    de Salles Painelli, Vitor; Saunders, Bryan; Sale, Craig; Harris, Roger Charles; Solis, Marina Yázigi; Roschel, Hamilton; Gualano, Bruno; Artioli, Guilherme Giannini; Lancha, Antonio Herbert

    2014-05-01

    Recent investigations have suggested that highly trained athletes may be less responsive to the ergogenic effects of β-alanine (BA) supplementation than recreationally active individuals due to their elevated muscle buffering capacity. We investigated whether training status influences the effect of BA on repeated Wingate performance. Forty young males were divided into two groups according to their training status (trained: T, and non-trained: NT cyclists) and were randomly allocated to BA and a dextrose-based placebo (PL) groups, providing four experimental conditions: NTPL, NTBA, TPL, TBA. BA (6.4 g day(-1)) or PL was ingested for 4 weeks, with participants completing four 30-s lower-body Wingate bouts, separated by 3 min, before and after supplementation. Total work done was significantly increased following supplementation in both NTBA (p = 0.03) and TBA (p = 0.002), and it was significantly reduced in NTPL (p = 0.03) with no difference for TPL (p = 0.73). BA supplementation increased mean power output (MPO) in bout 4 for the NTBA group (p = 0.0004) and in bouts 1, 2 and 4 for the TBA group (p ≤ 0.05). No differences were observed in MPO for NTPL and TPL. BA supplementation was effective at improving repeated high-intensity cycling performance in both trained and non-trained individuals, highlighting the efficacy of BA as an ergogenic aid for high-intensity exercise regardless of the training status of the individual.

  2. Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status.

    Science.gov (United States)

    Goss, Glenwood; Ferry, David; Wierzbicki, Rafal; Laurie, Scott A; Thompson, Joyce; Biesma, Bonne; Hirsch, Fred R; Varella-Garcia, Marileila; Duffield, Emma; Ataman, Ozlem U; Zarenda, Marc; Armour, Alison A

    2009-05-01

    To compare gefitinib with placebo in chemotherapy naïve patients with advanced non-small-cell lung cancer (NSCLC) and poor performance status. NSCLC patients (chemotherapy naïve, WHO performance status 2 or 3; unfit for chemotherapy; stage IIIB/IV) were randomly assigned to gefitinib (250 mg/d) plus best supportive care (BSC; n = 100) or placebo plus BSC (n = 101). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), objective response rate (ORR), quality of life (QOL), pulmonary symptom improvement (PSI), and safety. Correlation of gefitinib efficacy with EGFR gene copy number (fluorescent in situ hybridization [FISH]) was explored. Hazard ratios (HRs; gefitinib:placebo) were 0.82 (95% CI, 0.60 to 1.12; P = .217) for PFS and 0.84 (95% CI, 0.62 to 1.15; P = .272) for OS. As expected for this patient population, OS for both arms was poor, at about 3 months. ORRs were 6.0% (gefitinib) and 1.0% (placebo). QOL and PSI rates were 21.1% and 28.3% (gefitinib) and 20.0% and 28.3% (placebo), respectively. In EGFR FISH-positive patients (n = 32), HRs were 0.29 (95% CI, 0.11 to 0.73) for PFS and 0.44 (95% CI, 0.17 to 1.12) for OS. No unexpected adverse events occurred. There was no statistically significant difference in PFS, OS, and ORRs after treatment with gefitinib or placebo, in the overall population; improvements in QOL and symptoms were similar in both groups. Tolerability profile of gefitinib was consistent with previous studies. PFS was statistically significantly improved for gefitinib-treated patients with EGFR FISH-positive tumors.

  3. Randomized Phase II Study of Gefitinib Compared With Placebo in Chemotherapy-Naive Patients With Advanced Non–Small-Cell Lung Cancer and Poor Performance Status

    Science.gov (United States)

    Goss, Glenwood; Ferry, David; Wierzbicki, Rafal; Laurie, Scott A.; Thompson, Joyce; Biesma, Bonne; Hirsch, Fred R.; Varella-Garcia, Marileila; Duffield, Emma; Ataman, Ozlem U.; Zarenda, Marc; Armour, Alison A.

    2009-01-01

    Purpose To compare gefitinib with placebo in chemotherapy naïve patients with advanced non–small-cell lung cancer (NSCLC) and poor performance status. Patients and Methods NSCLC patients (chemotherapy naïve, WHO performance status 2 or 3; unfit for chemotherapy; stage IIIB/IV) were randomly assigned to gefitinib (250 mg/d) plus best supportive care (BSC; n = 100) or placebo plus BSC (n = 101). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), objective response rate (ORR), quality of life (QOL), pulmonary symptom improvement (PSI), and safety. Correlation of gefitinib efficacy with EGFR gene copy number (fluorescent in situ hybridization [FISH]) was explored. Results Hazard ratios (HRs; gefitinib:placebo) were 0.82 (95% CI, 0.60 to 1.12; P = .217) for PFS and 0.84 (95% CI, 0.62 to 1.15; P = .272) for OS. As expected for this patient population, OS for both arms was poor, at about 3 months. ORRs were 6.0% (gefitinib) and 1.0% (placebo). QOL and PSI rates were 21.1% and 28.3% (gefitinib) and 20.0% and 28.3% (placebo), respectively. In EGFR FISH-positive patients (n = 32), HRs were 0.29 (95% CI, 0.11 to 0.73) for PFS and 0.44 (95% CI, 0.17 to 1.12) for OS. No unexpected adverse events occurred. Conclusion There was no statistically significant difference in PFS, OS, and ORRs after treatment with gefitinib or placebo, in the overall population; improvements in QOL and symptoms were similar in both groups. Tolerability profile of gefitinib was consistent with previous studies. PFS was statistically significantly improved for gefitinib-treated patients with EGFR FISH-positive tumors. PMID:19289623

  4. Beyond adoption status: Post-adoptive parental involvement and children's reading and math performance from kindergarten to first grade.

    Science.gov (United States)

    Tan, Tony Xing; Kim, Eun Sook; Baggerly, Jennifer; Mahoney, E Emily; Rice, Jessica

    2017-01-01

    In this study, we went beyond adoption status to examine the associations between postadoption parental involvement and children's reading and math performance from kindergarten to first grade. Secondary data on a sample of adopted children and nonadopted children were drawn from the Early Childhood Longitudinal Study-Kindergarten Class of 1998 to 1999 (ECLS-K). Weighted data on the children's reading performance were available for 13,900 children (181 were adopted); weighted data on the children's math performance were available for 14,128 children (184 were adopted). Descriptive data showed no group difference in reading scores at all 3 Waves but adopted children scored lower than nonadopted children in math at Wave 2 (Spring of kindergarten) and Wave 3 (Spring of first grade). However, controlling for 6 covariates, latent growth modeling showed that adoption status was unrelated to Wave 1 reading and math scores or subsequent growth rate. Rather, parents' beliefs on skills needed to succeed in kindergarten were a significant predictor of reading and math performance at Wave 1 and subsequent growth rates, and parents' educational expectation was a significant predictor of growth rate in reading and math. Our findings highlight the importance of parental involvement in adopted children's learning. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  5. Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds

    Directory of Open Access Journals (Sweden)

    Dong-Hyun Shin

    2015-06-01

    Full Text Available Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs were evaluated in a small number of samples (240 horses. In the second stage, a relatively small number of markers identified to have large effects (170 SNPs were evaluated in a much larger number of samples (1,156 horses. We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds.

  6. Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630 - Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance

    Directory of Open Access Journals (Sweden)

    Luigi Giuliani

    2013-05-01

    Full Text Available Review of Henry S. Turner, The English Renaissance Stage. Geometry, Poetics, and the Practical Spatial Arts 1580-1630, Oxford University Press, Oxford, 2006, reimpr. 2010, 326 pp. ISBN: 978-0-19-959545-7 y Tim Fitzpatrick, Playwright, Space and Place in Early Modern Performance, Ashgate, Franham, 2011, 314 pp. ISBN: 978-1-4094-2827-5.

  7. Performance of a generic non-axisymmetric end wall in a single stage, rotating turbine at on and off-design conditions

    CSIR Research Space (South Africa)

    Snedden, Glen C

    2010-06-01

    Full Text Available The application of non-axisymmetric end walls in turbine stages has gained wide spread acceptance as a means to improve the performance of turbines in both power generation and aero-derivative applications. Non-axisymmetric end walls are aimed...

  8. A Five-Stage Prediction-Observation-Explanation Inquiry-Based Learning Model to Improve Students' Learning Performance in Science Courses

    Science.gov (United States)

    Hsiao, Hsien-Sheng; Chen, Jyun-Chen; Hong, Jon-Chao; Chen, Po-Hsi; Lu, Chow-Chin; Chen, Sherry Y.

    2017-01-01

    A five-stage prediction-observation-explanation inquiry-based learning (FPOEIL) model was developed to improve students' scientific learning performance. In order to intensify the science learning effect, the repertory grid technology-assisted learning (RGTL) approach and the collaborative learning (CL) approach were utilized. A quasi-experimental…

  9. Correlation between nutritional status and comprehensive physical performance measures among older adults with undernourishment in residential institutions

    Directory of Open Access Journals (Sweden)

    Singh DKA

    2014-08-01

    Full Text Available Devinder KA Singh,1 Zahara A Manaf,2 Noor Aini M Yusoff,3 Nur A Muhammad,2 Mei Fang Phan,1 Suzana Shahar2 1Physiotherapy Program, School of Rehabilitation Sciences, 2Nutrition and Dietetics Program, School of Health Care Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, 3ASIA Metropolitan University, Cheras, Malaysia Purpose: The consequences of combined undernourishment and decreased physical ­performance in older adults are debilitating and increases cost of care. To date, the information regarding the association between nutritional status and physical performance does not provide a complete picture. Most studies used limited or self-reported measures to evaluate physical performance. The objective of this study was to examine the correlation between nutritional status and comprehensive physical performance measures among undernourished older adults who reside in residential institutions.Methods: Forty-seven older adults (26 males, 21 females aged ≥60 (69.23±8.63 years who were identified as undernourished from two residential institutions participated in this study. A battery of physical performance tests (10 m gait speed test, dominant hand grip strength test, timed five-repetition sit-to-stand test, ten step test, arm curl test, scratch test, and respiratory muscle strength test, biochemical profiles (serum albumin, hemoglobin, serum ferritin, and prealbumin levels, and falls risk using the short-form Physiological Profile Approach were performed. The Functional Ability Questionnaire and Geriatric Depression Scale were also administered.Results: The results demonstrated that generally older adults with undernourishment scored poorly on the physical performance tests, had depression, and a high risk of falls. Biochemical results demonstrated that 10.9% of the participants were anemic, 63% had hypoalbuminemia (<3.5 g/dL, and 21.7% were at risk of protein energy malnutrition with prealbumin level (100–170 mg/L. A significant

  10. Water and sodium intake habits and status of ultra-endurance runners during a multi-stage ultra-marathon conducted in a hot ambient environment: an observational field based study

    Directory of Open Access Journals (Sweden)

    Costa Ricardo JS

    2013-01-01

    Full Text Available Abstract Background Anecdotal evidence suggests ultra-runners may not be consuming sufficient water through foods and fluids to maintenance euhydration, and present sub-optimal sodium intakes, throughout multi-stage ultra-marathon (MSUM competitions in the heat. Subsequently, the aims were primarily to assess water and sodium intake habits of recreational ultra-runners during a five stage 225 km semi self-sufficient MSUM conducted in a hot ambient environment (Tmax range: 32°C to 40°C; simultaneously to monitor serum sodium concentration, and hydration status using multiple hydration assessment techniques. Methods Total daily, pre-stage, during running, and post-stage water and sodium ingestion of ultra-endurance runners (UER, n = 74 and control (CON, n = 12 through foods and fluids were recorded on Stages 1 to 4 by trained dietetic researchers using dietary recall interview technique, and analysed through dietary analysis software. Body mass (BM, hydration status, and serum sodium concentration were determined pre- and post-Stages 1 to 5. Results Water (overall mean (SD: total daily 7.7 (1.5 L/day, during running 732 (183 ml/h and sodium (total daily 3.9 (1.3 g/day, during running 270 (151 mg/L ingestion did not differ between stages in UER (p vs. CON. Exercise-induced BM loss was 2.4 (1.2% (p p > 0.05 vs. CON pre-stage. Asymptomatic hyponatraemia (n = 8 UER, corresponding to 42% of sampled participants. Pre- and post-stage urine colour, urine osmolality and urine/plasma osmolality ratio increased (p p  Conclusion Water intake habits of ultra-runners during MSUM conducted in hot ambient conditions appear to be sufficient to maintain baseline euhydration levels. However, fluid over-consumption behaviours were evident along competition, irrespective of running speed and gender. Normonatraemia was observed in the majority of ultra-runners throughout MSUM, despite sodium ingestion under benchmark recommendations.

  11. Kalpakkam multigroup cross section set for fast reactor applications - status and performance

    International Nuclear Information System (INIS)

    Ramanadhan, M.M.; Gopalakrishnan, M.M.

    1986-01-01

    This report documents the status of the presently created set of multigroup constants at Kalpakkam. The list of nuclides processed and the details of multigroup structure are given. Also included are the particulars of dilutions and temperatures for each nuclide in the multigroup cross section set for which self shielding factors have been calculated. Using this new multigroup cross section set, measured integral quantities such as K-eff, central reaction rate ratios, central reactivity worths etc. were calculated for a few fast critical benchmark assemblies and the calculated values of neutronic parameters obtained were compared with those obtained using the available Cadarache cross section library and those published in literature for ENDF/B-IV based set and Japanese evaluated nuclear data library (JENDL). The details of analyses are documented along with the conclusions. (author). 17 refs., 12 tabs

  12. The Mirror Fusion Test Facility cryogenic system: Performance, management approach, and present equipment status

    International Nuclear Information System (INIS)

    Slack, D.S.; Chronis, W.C.

    1987-01-01

    The cryogenic system for the Mirror Fusion Test Facility (MFTF) is a 14-kW, 4.35-K helium refrigeration system that proved to be highly successful and cost-effective. All operating objectives were met, while remaining within a few percent of initial cost and schedule plans. The management approach used in MFTF allowed decisions to be made quickly and effectively, and it helped keep costs down. Manpower levels, extent and type of industrial participation, key aspects of subcontractor specifications, and subcontractor interactions are reviewed, as well as highlights of the system tests, operation, and present equipment status. Organizations planning large, high-technology systems may benefit from this experience with the MFTF cryogenic system

  13. Cognitive performance and iron status are negatively associated with hookworm infection in Cambodian schoolchildren

    NARCIS (Netherlands)

    Kuong, Khov; Fiorentino, Marion; Perignon, Marlene; Chamnan, Chhoun; Berger, Jacques; Sinuon, Muth; Molyden, Vann; Burja, Kurt; Parker, Megan; Ly, Sou Chheng; Friis, Henrik; Roos, Nanna; Wieringa, Frank T.

    2016-01-01

    Soil-transmitted helminth (STH) infection has been associated with lower cognitive performance of schoolchildren. To identify pathways through which STH infection might affect school performance, baseline data from a large rice-fortification trial in Cambodian schoolchildren were used to

  14. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sukkwon; Jin, Hyunggon; Shin, Kyuin; Choi, Boguen; Lee, Eohwak; Yoon, Jaesung; Lee, Dongwon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Duckhoi; Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m{sup 2} high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun.

  15. Performance status and change - measuring education system effectiveness with data from PISA 2000-2009

    NARCIS (Netherlands)

    Lenkeit, J.; Caro, D.H.

    2014-01-01

    Reports of international large-scale assessments tend to evaluate and compare education system performance based on absolute scores. And policymakers refer to high-performing and economically prosperous education systems to enhance their own systemic features. But socioeconomic differences between

  16. Performance Status and Change--Measuring Education System Effectiveness with Data from PISA 2000-2009

    Science.gov (United States)

    Lenkeit, Jenny; Caro, Daniel H.

    2014-01-01

    Reports of international large-scale assessments tend to evaluate and compare education system performance based on absolute scores. And policymakers refer to high-performing and economically prosperous education systems to enhance their own systemic features. But socioeconomic differences between systems compromise the plausibility of those…

  17. Growth performance and development of internal organ, and gastrointestinal tract of calf supplementation with calcium propionate at various stages of growth period

    Science.gov (United States)

    Wu, Xin; Chen, Wanbao; Zhang, Yawei; Jiang, Yuming; Meng, Qingxiang; Zhou, Zhenming

    2017-01-01

    To investigate the effects of calcium propionate (CaP) supplementation on performance, the development of the internal organ, and gastrointestinal tract of calves at various stages of growth period, 54 male Jersey calves (age = 7 ± 1 d, body weight(BW) = 23.1 ± 1.2 kg) were randomly allocated to three treatment groups. While control calves were fed basis dietary with no additives (0CaP), other treatment calves were fed basis dietary supplementation with CaP at 50 (5CaP) or 100 (10CaP) g kg−1 dry matter. The experiment lasted 160 d and was divided into three feeding stages: Stage 1 (d 0 to 30), Stage 2 (d 31 to 90), and Stage 3 (d 91 to160). Six calves from each group were randomly selected and slaughtered on days 30, 90, and 160 when at the conclusion of each experimental feeding stage. The BW of calves increased with 10CaP after feeding 90 d, whereas it increased with 5CaP and 10CaP at feeding 120d and 160d compared to 0CaP. The 10CaP group improved average daily gain (ADG) of calves at stage 2, and d120-160 of stage 3 compared with the 0CaP group. The ADG of 5CaP was greater than the 0CaP group only at 120–160 d of stage 3 compared with the 0CaP group. The results of feed efficiency were in agreed with ADG as no dry matter intake difference at all stages of growth period. The 10CaP treatment exhibited the greatest spleen weight among the treatment at the end of the experiment; the liver weight of the 5CaP and 10CaP calves at feeding 90 d and of the 10CaP calves at feeding 160 d and were greater than those of the 0CaP animals. The CaP at the tested doses increased the rumen weight after feeding 90d of Jersey calves, and also improved the development of intestine. In conclusion, dietary supplementation with calcium propionate at the tested doses caused a beneficial effect in the growth performance and gastrointestinal tract traits of Jersey calves, thus to add 10% CaP before feeding 90 days was better and 5% CaP supplementation was expected at the period for

  18. Performance and genome-centric metagenomics of thermophilic single and two-stage anaerobic digesters treating cheese wastes

    DEFF Research Database (Denmark)

    Fontana, Alessandra; Campanaro, Stefano; Treu, Laura

    2018-01-01

    configurations were remarkably different, demonstrating a higher methanogenic biodiversity in the two-stage configuration. In fact, the acidogenic reactor of the serial configuration was almost solely composed by the lactose degrader Bifidobacterium crudilactis UC0001. The predictive functional analyses...... Tepidanaerobacter acetatoxydans UC0018 and to the absence of aceticlastic methanogens....

  19. Status of the ATLAS Liquid Argon Calorimeter and its performance after one year of LHC operation

    CERN Document Server

    "March, L; The ATLAS collaboration

    2011-01-01

    The ATLAS experiment is designed to study the proton-proton collisions produced at the LHC with a centre-of-mass energy of 14 TeV. Liquid argon (LAr) sampling calorimeters are used in ATLAS for all electromagnetic calorimetry and partly for hadronic calorimetry. The calorimeter system consists of an electromagnetic barrel calorimeter and two endcaps with electromagnetic (EMEC), hadronic (HEC) and forward (FCAL) calorimeters. The different parts of the LAr calorimeter have been installed inside the ATLAS cavern between October 2004 and April 2006. Since October 2006 the detector has been operated with liquid argon at nominal high voltage, and fully equipped with readout electronics including a LVL1 calorimeter trigger system. First cosmic runs were recorded and used in various stages of commissioning. Starting in September 2008 beam related events were collected for the first time with single beams circulating in the LHC ring providing first beam-gas interactions and then beam-collimator splash events. The fir...

  20. Effect of citric acid, avilamycin, and their combination on the performance, tibia ash, and immune status of broilers.

    Science.gov (United States)

    Chowdhury, R; Islam, K M S; Khan, M J; Karim, M R; Haque, M N; Khatun, M; Pesti, G M

    2009-08-01

    The aim of this study was to determine the effect of the supplementation of an organic acid (citric acid), antibiotic growth promoter (avilamycin), and their combination for a period of 35 d on the growth, feed efficiency, carcass yield, tibia ash, and immune status of broilers. One hundred sixty 1-d-old broiler chicks (Hubbard Classic) were randomly distributed into 4 groups with 4 replicate cages having 10 birds in each. A corn-soybean-based diet was used as the basal diet (control). The basal diet was supplemented with an organic acid (citric acid, 0.5%), an antibiotic growth promoter (avilamycin, 0.001%), and their combination in other groups. The highest BW was attained in citric acid-fed chicks (1,318 g), which was significantly (P 0.05). Total feed intake was higher in citric acid-fed chicks compared with antibiotic-supplemented chicks. The addition of citric acid improved feed conversion efficiency (g of weight gain/ kg of feed intake) significantly (P ash percentage significantly (P ash, and immune status of broilers. Therefore, citric acid might be a useful additive instead of antibiotic growth promoters such as avilamycin, considering performance and health status of broilers.

  1. Oral health status and academic performance among Ohio third-graders, 2009-2010.

    Science.gov (United States)

    Detty, Amber M R; Oza-Frank, Reena

    2014-01-01

    Although recent literature indicated an association between dental caries and poor academic performance, previous work relied on self-reported measures. This analysis sought to determine the association between academic performance and untreated dental caries (tooth decay) using objective measures, controlling for school-level characteristics. School-level untreated caries prevalence was estimated from a 2009-2010 oral health survey of Ohio third-graders. Prevalence estimates were combined with school-level academic performance and other school characteristics obtained from the Ohio Department of Education. Linear regression models were developed as a result of bivariate testing, and final models were stratified based upon the presence of a school-based dental sealant program (SBSP). Preliminary bivariate analysis indicated a significant relationship between untreated caries and academic performance, which was more pronounced at schools with an SBSP. After controlling for other school characteristics, the prevalence of untreated caries was found to be a significant predictor of academic performance at schools without an SBSP (P=0.001) but not at schools with an SBSP (P=0.833). The results suggest the association between untreated caries and academic performance may be affected by the presence of a school-based oral health program. Further research focused on oral health and academic performance should consider the presence and/or availability of these programs. © 2014 American Association of Public Health Dentistry.

  2. Effects of Wine by-Products on Growth Performance, Complete Blood Count and Total Antioxidant Status in Broilers

    OpenAIRE

    Pascariu, SM; Pop, IM; Simeanu, D; Pavel, G; Solcan, C

    2017-01-01

    ABSTRACT This study aimed to investigate the effect of whole grape pomace (GP), grape seed (GS) and grape pomace polyphenolic extract (GPEP) on growth performance, total antioxidant status (TAS) and complete blood count (CBC) of 40-day-old chicks (hybrid Cobb 500). A total of 432 unsexed one-day-old chicks were divided into six groups: control (CON) and five experimental groups, 10 g/kg GP, 20 g/kg GP, 5 g/kg GS, 10 g/kg GS and 15 mL/L GPEP. The results showed a higher increase in growing rat...

  3. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance

    OpenAIRE

    Boyett, James C.; Giersch, Gabrielle E. W.; Womack, Christopher J.; Saunders, Michael J.; Hughey, Christine A.; Daley, Hannah M.; Luden, Nicholas D.

    2016-01-01

    This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg−1·min−1) were divided into tertiles based on training levels, with top and bottom tertiles designated as ‘trained’ (n = 7) and ‘untrained’ (n = 7). Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling tim...

  4. THE EFFECTS OF INCOME, GENDER, AGE, EDUCATION, WORKING PERIOD, INSURANCE, TRAINING, AND WORKER STATUS ON OUTSOURCED AND WORKERS PERFORMANCE IN SOUTH SUMATERA IN MANUFACTURING COMPANIES

    Directory of Open Access Journals (Sweden)

    Ratna Juwita

    2017-06-01

    Full Text Available This research investigated the effects of income, gender, age, education, working period, insurance, training and workers’ status (outsourcing or permanent on performance. The result showed that gender, education, insurance, training and status had positive and significant effect on performace. Income had significant and negative effect on performance, the increased income would decrease performance. Age had positive but not significant effect, the increased age would decrease performance. Working period had negative but not significsnt effect on performance, the short working period would decrease performance.

  5. Effects of anticoccidial and antibiotic growth promoter programs on broiler performance and immune status

    Science.gov (United States)

    This study investigated the effects of various coccidiosis control programs in combination with antibiotic growth promoters (AGPs) on growth performance and host immune responses in broiler chickens. The coccidiosis programs that were investigated include in ovo coccidiosis vaccination (CVAC) with ...

  6. International experience and status of fuel element performance and modelling for water reactors

    International Nuclear Information System (INIS)

    Gittus, J.H.

    1982-04-01

    Current knowledge concerning water reactor fuel performance and technology is reviewed (212 references). The emphasis is on aspects of in-reactor performance including behaviour in accidents. Computer models for predicting fuel behaviour during the ordinary running of the reactor and during accidents are described. These codes include COMETHE, HOTROD, SLEUTH-SEER and FRAPCON. Their agreement with experimental data is examined. (U.K.)

  7. Current status of the tasks performed by the Nuclear Fuel Department for the CAREM project

    International Nuclear Information System (INIS)

    Kaufmann, Federico; Perez, Lidia E.; Perez, Aaldo; Marchi, Daniel E.

    2009-01-01

    CAREM Project required to the Nuclear Fuels Department to perform the necessary tasks to define the powder characteristics and natural UO 2 -Gd 2 O 3 , UO 2 -1.8 and 3.1 % enrichment fuel pellets manufacturing and control parameters. To start with these tasks it was necessary to hire and train staff, begin the licensing process of the facilities, update infrastructure works and equipment of existing facilities. A brief description of the tasks performed is shown. (author)

  8. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and li......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments...

  9. Prognostic significance of Gleason score 7 (3+4 and Gleason score 7 (4+3 in prostatic adenocarcinoma in relation to clinical stage, androgen tissue status and degree of neuroendocrine differentiation

    Directory of Open Access Journals (Sweden)

    Mijović M.

    2014-01-01

    Full Text Available Prognosis and choice of treatment of adenocarcinoma of the prostate (ADCP directly depend on the numerous of predictive factors, among which the most important are summary histological tumor grade (Gleason score, which is the sum of the first and second dominant histological grade and clinical stage. According to recent research these factors include androgen tissue status and degree of neuroendocrine differentiation. The importance of the first and second dominant histological grade becomes particularly important in ADCP Gleason score 7. Tumors with worse prognosis considered to be ADCP of higher Gleason score, the advanced clinical stage, androgen independent tumors and tumors that show a higher degree of neuroendocrine differentiation. The aim of the study was to determine the predictive significance of ADCP Gleason score 7 (3+4 and ADCP Gleason score 7 (4+3 in relation to clinical stage, androgen tissue status and degree of focal neuroendocrine differentiation. The study included 33 ADCP of Gleason score 7,26 (78.79% ADCP 7 (3+4 and 7 (21.21% ADCP 7 (4+3. All tumors are most often diagnosed with stage D2, when there are already distant metastases. ADCP of Gleason score 7 (4+3 were diagnosed more often at this stage, among them there are more androgen independent tumors and they show a greater degree of focal neuroendocrine differentiation. All the results are in accordance with data from the literature suggesting that ADCP of Gleason score 7 (4+3 have a worse prognosis than ADCP of Gleason score 7 (3 +4.

  10. Aspects of Cultural Landscape Application on Classical Stage Art. Ballet Performance in the Open Space as a Significant Element of the Cultural Landscape

    Directory of Open Access Journals (Sweden)

    Jelena Lebedeva

    2016-04-01

    Full Text Available The article examines the applications aspects of cultural landscape for the preparation of the classical performing arts staging. Research findings highlighted that the cultural landscape (parks, estates, castles, bastions, etc. objects occupies an increasingly important role in public recreation and classical art development programs. At the same time it is noted that event’s aesthetic and emotional quality suffers due to the fact that no specific attention was given for the preparation of the event space. More methodological materials are necessary for preparation of this type of design spaces. In Lithuania classical performing arts events in cultural landscape open spaces are based on XVI–XVII century tradition and has good prospects for modern development. A review of some of the classical art events installations, based on the importance of quality of open spaces influence on the emotional impact, that should be an integral part of the cultural event. The author summarizes his experience of ballet events in open spaces in the cultural landscape – Klaipėda, Trakai. Presented is Tchaikovsky's ballet “Swan Lake” construction in Klaipėda John Hill project that includes infrastructure and environmental design concept: audience space, stage design, stage design performance solutions. Analogous key decisions are later adapted to the ballet performance in the natural environment of the lake Trakai. Experience of this project dictated the necessity of deeper understanding and methodological basis for the classical performing arts analysis and design.

  11. ATLAS SemiConductor Tracker and Pixel Detector: Status and Performance

    CERN Document Server

    Reeves, K; The ATLAS collaboration

    2012-01-01

    The Semi-Conductor Tracker (SCT) and the Pixel Detector are the key precision tracking devices in the Inner Detector of the ATLAS experiment at CERN LHC. The SCT is a silicon strip detector and is constructed of 4088 silicon detector modules for a total of 6.3 million strips. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The SCT silicon micro-strip sensors are processed in the planar p-in-n technology. The signals from the strips are processed in the front-end ASICS ABCD3TA, working in the binary readout mode. The Pixel Detector consists of approximately 80 million pixels that are individually read out via chips bump-bonded to 1744 n-in-n silicon substrates. In the talk the current status of the SCT and Pixel Detector will be reviewed. We will report on the operation of the detectors including an overview of the issues we encountered and the observation of significant increases in leakage currents (as expected) from bulk ...

  12. Current status of the transient integral fuel element performance code URANUS

    International Nuclear Information System (INIS)

    Preusser, T.; Lassmann, K.

    1983-01-01

    To investigate the behavior of fuel pins during normal and off-normal operation, the integral fuel rod code URANUS has been extended to include a transient version. The paper describes the current status of the program system including a presentation of newly developed models for hypothetical accident investigation. The main objective of current development work is to improve the modelling of fuel and clad material behavior during fast transients. URANUS allows detailed analysis of experiments until the onset of strong material transport phenomena. Transient fission gas analysis is carried out due to the coupling with a special version of the LANGZEIT-KURZZEIT-code (KfK). Fuel restructuring and grain growth kinetics models have been improved recently to better characterize pre-experimental steady-state operation; transient models are under development. Extensive verification of the new version has been carried out by comparison with analytical solutions, experimental evidence, and code-to-code evaluation studies. URANUS, with all these improvements, has been successfully applied to difficult fast breeder fuel rod analysis including TOP, LOF, TUCOP, local coolant blockage and specific carbide fuel experiments. Objective of further studies is the description of transient PCMI. It is expected that the results of these developments will contribute significantly to the understanding of fuel element structural behavior during severe transients. (orig.)

  13. Sleep-stage scoring in mice: The influence of data pre-processing on a system's performance.

    Science.gov (United States)

    Katsageorgiou, Vasiliki-Maria; Lassi, Glenda; Tucci, Valter; Murino, Vittorio; Sona, Diego

    2015-08-01

    Sleep-stage analysis in mice and rats has received growing attention in recent years, due to the fact that mice display electrical activity during sleep which has underlying similarities with that of human sleep. Both conventional manual and automatic sleep-wakefulness scoring are rule based tasks which use brain waves measured by Electroencephalogram (EEG) and activity detected by Electromyography (EMG) of skeletal muscles. Several works have been conducted trying to provide an automatic sleep-scoring system on the basis of machine learning methods. In this study we try to understand the reasons behind the complexity of this problem and we emphasize the importance of normalization procedure that leads to a better stage discrimination comparing different classification methods.

  14. Image quality validation of Sentinel 2 Level-1 products: performance status at the beginning of the constellation routine phase

    Science.gov (United States)

    Francesconi, Benjamin; Neveu-VanMalle, Marion; Espesset, Aude; Alhammoud, Bahjat; Bouzinac, Catherine; Clerc, Sébastien; Gascon, Ferran

    2017-09-01

    Sentinel-2 is an Earth Observation mission developed by the European Space Agency (ESA) in the frame of the Copernicus program of the European Commission. The mission is based on a constellation of 2-satellites: Sentinel-2A launched in June 2015 and Sentinel-2B launched in March 2017. It offers an unprecedented combination of systematic global coverage of land and coastal areas, a high revisit of five days at the equator and 2 days at mid-latitudes under the same viewing conditions, high spatial resolution, and a wide field of view for multispectral observations from 13 bands in the visible, near infrared and short wave infrared range of the electromagnetic spectrum. The mission performances are routinely and closely monitored by the S2 Mission Performance Centre (MPC), including a consortium of Expert Support Laboratories (ESL). This publication focuses on the Sentinel-2 Level-1 product quality validation activities performed by the MPC. It presents an up-to-date status of the Level-1 mission performances at the beginning of the constellation routine phase. Level-1 performance validations routinely performed cover Level-1 Radiometric Validation (Equalisation Validation, Absolute Radiometry Vicarious Validation, Absolute Radiometry Cross-Mission Validation, Multi-temporal Relative Radiometry Vicarious Validation and SNR Validation), and Level-1 Geometric Validation (Geolocation Uncertainty Validation, Multi-spectral Registration Uncertainty Validation and Multi-temporal Registration Uncertainty Validation). Overall, the Sentinel-2 mission is proving very successful in terms of product quality thereby fulfilling the promises of the Copernicus program.

  15. Experimental investigation on ignition and lean blow-out performance of a multi-sector centrally staged combustor

    Science.gov (United States)

    Liu, Fuqiang; Zhang, Kaiyu; Mu, Yong; Liu, Cunxi; Yang, Jinhu; Xu, Gang; Zhu, Junqiang

    2014-10-01

    Improvement on extinction and pollution emission have become one of the most prominent research topics in gas turbine. It is widely recognized that the fuel/air mixture distribution in the recirculation zone is a critical factor in improving lean blow-out (LBO) and ignition. This paper proposed a new low emission scheme with fuel staged centrally and hybrid injector to improve flameout and emission. A relative small amount of fuel enters into central pilot airblast atomizer burner and then atomized by inner swirl air. The remaining majority of fuel is directly injected into vane channels of the primary swirler through a series of holes located on the sidewall of the main stage. Only pilot stage is fueled under ignition and lean flameout condition. The uniformity of fuel/air mixture distribution in the primary zone of the new design decreases NOX emission, meanwhile the fuel air mixture in pilot recirculation zone is locally rich to improve flameout and ignition. Experimental investigation was conducted to compare the new scheme with baseline design of dual-swirler in terms of LBO and ignition characteristics under the same condition in a multi-sector combustor. It is found that the fuel-air ratio of ignition limit and LBO decrease with the reference velocity increasing. The experimental results also show that the new scheme successfully improve lean blow-out and broaden the operation range of the combustor. The experimental results indicated that the centrally staged scheme can widen the operation boundary of the combustor and can provide guidance for design and optimization of combustion chamber.

  16. The method shaft projects integrator in the process of forming the teaching mode interdisciplinary performance at the initial stage

    Directory of Open Access Journals (Sweden)

    Beatriz Páez Rodríguez

    2010-06-01

    Full Text Available In this article is approached the practical viability of the method of projects for the contribution to the process of formation in the professional, pedagogic and interdisciplinary way of acting in the initial stage of the trainee teachers, which is inserted in the professional formation in the curricular and in the extracurricular field, so that the formation of the student be integral and inside the context.

  17. Monitoring the status of forests and rangelands in the Western United States using ecosystem performance anomalies

    Science.gov (United States)

    Rigge, Matthew B.; Wylie, Bruce; Gu, Yingxin; Belnap, Jayne; Phuyal, Khem P.; Tieszen, Larry

    2013-01-01

    The effects of land management and disturbance on ecosystem performance (i.e. biomass production) are often confounded by those of weather and site potential. The current study overcomes this issue by calculating the difference between actual and expected ecosystem performance (EEP) to generate ecosystem performance anomalies (EPA). This study aims to delineate and quantify average EPA from 2000–2009 within the Greater Platte and Upper Colorado River Basins, USA. Moderate Resolution Imaging Spectroradiometer (MODIS) normalized difference vegetation index (NDVI) images averaged over the growing season (GSN) served as a proxy of actual ecosystem performance. Yearly EEP was determined with rule-based piecewise regression tree models of abiotic data (climate, soils, elevation, etc.), independently created for each land cover. EPA were calculated as the residuals of the EEP to GSN relationship, and characterized as normal performing, underperforming, and overperforming at the 90% confidence level. Validation revealed that EPA values were related to biomass production (R2 = 0.56, P = 0.02) and likely to the proportion of biomass removed by livestock in the Nebraska Sandhills. Overall, 60.6% of the study area was (normal) performing near its EEP, 3.0% was severely underperforming, 5.0% was highly overperforming, and the remainder was slightly underperforming or overperforming. Generally, disturbances such as fires, floods, and insect damage, in addition to high grazing intensity, result in a negative EPA. Conversely, mature stands and appropriate management often result in positive EPA values. This method provides information critical to land managers to evaluate the appropriateness of previous management practices and restoration efforts and quantify disturbance impacts. Results are at a scale sufficient for many of the large management units of the region and for locating areas needing further investigation. Applications of EPA data to monitoring invasive species

  18. Status of the construction and performances of the neutron Zero Degree Calorimeters of the ALICE experiment

    Energy Technology Data Exchange (ETDEWEB)

    Siddi, E. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Arnaldi, R. [Universita di Torino and INFN Sezione di Torino (Italy); Chiavassa, E. [Universita di Torino and INFN Sezione di Torino (Italy); Cicalo, C. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Cortese, P. [Universita del Piemonte Orientale, Alessandria and INFN Sezione di Torino (Italy); De Falco, A. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Dellacasa, G. [Universita del Piemonte Orientale, Alessandria and INFN Sezione di Torino (Italy); De Marco, N. [Universita di Torino and INFN Sezione di Torino (Italy); Ferretti, A. [Universita di Torino and INFN Sezione di Torino (Italy); Gallio, M. [Universita di Torino and INFN Sezione di Torino (Italy); Masoni, A. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Mereu, P. [Universita di Torino and INFN Sezione di Torino (Italy); Musso, A. [Universita di Torino and INFN Sezione di Torino (Italy); Oppedisano, C. [Universita di Torino and INFN Sezione di Torino (Italy); Piccotti, A. [Universita di Torino and INFN Sezione di Torino (Italy); Puddu, G. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Scomparin, E. [Universita di Torino and INFN Sezione di Torino (Italy); Serci, S. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Travaglia, G. [Universita di Torino and INFN Sezione di Torino (Italy); Usai, G. [Universita di Cagliari and INFN Sezione di Cagliari, Via Ospedale 72, Cagliari CA9100 (Italy); Vercellin, E. [Universita di Torino and INFN Sezione di Torino (Italy)

    2004-12-11

    The details of the construction of the neutron Zero Degree Calorimeters (ZN) of the ALICE Experiment, as well as their performances, will be presented. These spaghetti calorimeters will measure the energy lost by spectator nucleons in heavy-ion collisions. They are made of an absorber (tungsten alloy) filled with silica fibers, in which the charged particles of the shower produce Cherenkov light. The final neutron calorimeters have been built and their performances studied at the CERN SPS using pion and positron beams with momentum ranging from 50 to 150GeV/c. The main features like linearity of the response and resolution as a function of energy will be presented.

  19. Development of an Information Delivery Manual for Early Stage BIM-based Energy Performance Assessment and Code Compliance as a Part of DGNB Pre-Certification

    DEFF Research Database (Denmark)

    Petrova, Ekaterina Aleksandrova; Romanska, Iva; Stamenov, Martin

    2017-01-01

    The evolvement of integrated practices utilizing Building Performance Simulations has made it possible to address the growing needs of the building design. Furthermore, including a sustainability rating system in the early stages ensures a superior environmental performance and a common goal...... for all parties involved. However, the persistent lack of early collaboration and process standardization prevent reaching the full potential of BIM-based performance evaluation. By following buildingSMART’s methodology for development of Information Delivery Manual/Model View Definition, this paper...

  20. The sentinel lymph node status is an important factor for predicting clinical outcome in patients with Stage I or II cutaneous melanoma

    NARCIS (Netherlands)

    Statius Muller, M. G.; van Leeuwen, P. A.; de Lange-de Klerk, E. S.; van Diest, P. J.; Pijpers, R.; Ferwerda, C. C.; Vuylsteke, R. J.; Meijer, S.

    2001-01-01

    In a cohort of patients, the authors investigated whether and to what extent the sentinel lymph node (SLN) status contributes to predicting the probability of remaining disease free for at least 3 years. In addition, several traditional prognostic factors were analyzed: Breslow thickness, Clark

  1. Effect of 12-Week Vitamin D Supplementation on 25[OH]D Status and Performance in Athletes with a Spinal Cord Injury.

    Science.gov (United States)

    Flueck, Joelle Leonie; Schlaepfer, Max Walter; Perret, Claudio

    2016-09-22

    (1) BACKGROUND: studies with able-bodied athletes showed that performance might possibly be influenced by vitamin D status. Vitamin D seems to have a direct impact on neuromuscular function by docking on vitamin D receptors in the muscle tissue. Additionally, a high prevalence of vitamin D deficiency was shown not only in infants and in the elderly but also in healthy adults and spinal cord injured individuals. Therefore, the aim of our study was to investigate whether a vitamin D dose of 6000 IU daily over 12 weeks would be sufficient to increase vitamin D status in indoor wheelchair athletes to a normal or optimal vitamin D level and whether vitamin D deficiency is associated with an impairment in muscle performance in these individuals; (2) METHODS: vitamin D status was assessed in indoor elite wheelchair athletes in order to have a baseline measurement. If vitamin D status was below 75 nmol/L, athletes were supplemented with 6000 IU of vitamin D daily over 12 weeks. A vitamin D status over 75 nmol/L was supplemented with a placebo supplement. Vitamin D status, as well as a Wingate test and an isokinetic dynamometer test, were performed at baseline and after six and 12 weeks; (3) RESULTS: 20 indoor elite wheelchair athletes participated in this double-blind study. All of these athletes showed an insufficient vitamin D status at baseline and were, therefore, supplemented with vitamin D. All athletes increased vitamin D status significantly over 12 weeks and reached an optimal level. Wingate performance was not significantly increased. Isokinetic dynamometer strength was significantly increased but only in the non-dominant arm in isometric and concentric elbow flexion; (4) CONCLUSION: a dose of 6000 IU of vitamin D daily over a duration of 12 weeks seems to be sufficient to increase vitamin D status to an optimal level in indoor wheelchair athletes. It remains unclear, whether upper body performance or muscle strength and vitamin D status are associated with each

  2. Effect of changes in the nutritional status on the performances of growing Creole kids during an established nematode parasite infection.

    Science.gov (United States)

    Ceï, W; Archimède, H; Arquet, R; Félicité, Y; Feuillet, D; Nepos, A; Mulciba, P; Etienne, T; Alexandre, G; Bambou, J C

    2017-04-01

    In this study, we evaluated the effect of changes in the nutritional status on the performances of growing Creole kids during an established experimental gastrointestinal nematode (GIN) infection. Eighteen 6-month-old Creole kids were distributed in two main groups infected (I) and non-infected (NI) and were placed for a period of 4 weeks on each of three diets differing in their nutritional values: (1) fresh grass (FG, 6.7 MJ/kg dry matter (DM) and 7.9% crude protein (CP)) non-supplemented, (2) FG supplemented with a commercial concentrate (CC, 12.2 MJ/kg DM and 20.6% of CP), and (3) FG supplemented with dried banana (Ban, 11.1 MJ/kg DM and 4.3% CP). The experiment was designed as a split-plot with experimental infection (I and NI) as the main plot and the diets (FG, CC, and Ban) as the subplots with three replicates. We showed a significant effect of the diet changes on the fecal egg counts. A higher dry matter intake, digestibility, and growth rate were observed with the CC diet but together with a slight but significant increase of the intensity of the GIN infection. These data suggest that the improvement of the protein nutritional status during an establish GIN infection would improve the animal performance at the expense of the mechanism involved in the control of the infection.

  3. The effect of cognitive status and visuospatial performance on affective theory of mind in Parkinson’s disease

    Science.gov (United States)

    McKinlay, Audrey; Albicini, Michelle; Kavanagh, Phillip S

    2013-01-01

    It is now well accepted that theory of mind (ToM) functioning is impaired in Parkinson’s disease (PD) patients. However, what remain unknown are the functions that underlie this impairment. It has been suggested that cognitive skills may be key in this area of functioning; however, many of the cognitive tests used to assess this have relied on intact visuospatial abilities. This study aimed to examine whether deficits in ToM were generated by cognitive or visuospatial dysfunction and the mediating effect of visuospatial function on ToM performance. Fifty PD patients (31 male, 19 female; mean age = 66.34 years) and 49 healthy controls (16 male, 33 female; mean age = 67.29 years) completed a ToM task (reading the mind in the eyes) and visuospatial task (line orientation). The results revealed that current cognitive status was a significant predictor for performance on the ToM task, and that 54% of the total effect of cognitive status on ToM was mediated by visuospatial abilities. It was concluded that visuospatial functioning plays an important mediating role for the relationship between executive dysfunction and affective ToM deficits in PD patients, and that visuospatial deficits may directly contribute to the presence of affective ToM difficulties seen in individuals with PD. PMID:24019747

  4. The Investigation of Physical Performance Status of Visually and Hearing Impaired Applying Judo Training Program

    Science.gov (United States)

    Karakoc, Onder

    2016-01-01

    It was aimed to investigate the physical performances of visually and hearing impaired doing judo training in this study. 32 male athletes, who were doing judo training, volunteer and, visually and hearing impaired, participated in this study. The investigation was applied to visually impaired (N = 12, mean ± SD; age: 25.75 ± 3.55 years, height:…

  5. Annual Status Report (FY2014) 200 West and 200 East Performance Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M Hill Plateau Remediation Company, Richland, WA (United States); Khaleel, R. [INTERA, Inc., Austin, TX (United States); Mehta, S. [CH2M Hill Plateau Remediation Company, Richland, WA (United States)

    2015-03-24

    This annual review provides the projected dose estimates of radionuclide inventories disposed in the active Low-Level Waste Burial Grounds (LLBGs) since September 26, 1988. These estimates are calculated using the original does methodology developed in the performance assessment analyses.

  6. Cognitive performance and iron status are negatively associated with hookworm infection in Cambodian schoolchildren

    DEFF Research Database (Denmark)

    Khov, Kuong; Fiorentino, Marion; Perignon, Marlene

    2016-01-01

    performance was assessed using Raven's Colored Progressive Matrices (RCPM), block design, and picture completion. STH infection was found in 18% of the children; almost exclusively hookwork infection. After adjusting for age and gender, raw cognitive test scores were significantly lower in hookworm...

  7. Vitamin D status predicts physical performance and its decline in older persons

    NARCIS (Netherlands)

    Wicherts, Ilse S; van Schoor, Natasja M; Boeke, A Joan P; Visser, Marjolein; Deeg, Dorly J H; Smit, Jan; Knol, Dirk L; Lips, Paul

    CONTEXT: Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness. OBJECTIVE: The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25-OHD) concentration with current physical performance and its decline

  8. Growth performance and iron status of rural Beninese school-age ...

    African Journals Online (AJOL)

    A better nutrition in schoolage children is associated with increased school performances and a better school achievement. School-age children are dependent on their parents for access to adequate foods and nutrition but, in areas characterised by a unimodal climate with only one rainy season and one dry season, ...

  9. Understanding white matter integrity stability for bilinguals on language status and reading performance.

    Science.gov (United States)

    Cummine, Jacqueline; Boliek, Carol A

    2013-03-01

    Recent studies using diffusion tensor imaging (DTI) have described overall white matter integrity in bilinguals but have not related structural neural pathways to language functions. The current study examined white matter integrity and its relationship to reading skill in monolingual English and bilingual Chinese-English speakers. Eleven monolingual speakers (mean age 28.5 years) and 13 bilingual speakers (mean age 24.2 years; English as a second language was acquired post 5 years of age) participated. Behavioural response times and accuracy rates to name regular and exception words were recorded. Participants were then scanned using a standardized DTI protocol. Fractional anisotropy (FA) and mean diffusivity values were derived from a voxelwise statistical analysis for comparisons between participant groups. Tests for relationships between response time and FA were also conducted. Our results show minimal regions of higher FA for monolinguals when compared to bilinguals and no regions of higher FA for bilinguals when compared to monolinguals, which indicates that white matter integrity may not stabilize in bilinguals until late adulthood. We do show several regions where an increase in FA is associated with faster response times. Interestingly, the FA-response time relationship varies between groups and between word types, which may reflect an increased processing demand for retrieval of difficult words (e.g., exception words). These results provide some support for the interference control and reduced frequency hypotheses outlined by Jones et al. (Cerebr Cortex 22:892-902, 2012). The current findings advance our understanding of the underlying cortical networks associated with language status and reading skill in monolingual and bilingual adults.

  10. Status of radionuclide sorption-desorption studies performed by the WRIT program

    International Nuclear Information System (INIS)

    Serne, R.J.; Relyea, J.F.

    1981-01-01

    This paper focuses on interactions between dissolved radionuclides in groundwater and rocks and sediments away from the nearfield repository. Two approaches were used to study the primary mechanism, adsorption-desorption. Empirical studies rely on distribution coefficient measurements, and mechanism studies strive to identify, differentiate, and quantify the processes that control nuclide retardation. The status of sorption mechanism studies is discussed, with emphasis on delineating the usefulness of ideal ion-exchange, site-binding electrical double-layer, and redox-controlled sorption constructs. Since studies to date show greater potential for site-binding electrical double-layer models, future efforts will concentrate on this construct. Laboratory studies are discussed which corroborate the importance of redox reactions in causing nuclide retardation for multivalent elements, such as Tc, Np, Pu, and U. Results suggest that both solution-mediated reduction, such as the Fe(II)-Fe(III) couple, and solid-solution heterogeneous reduction reactions, such as reduction of solution Pu(VI) at the mineral surface by structural Fe(II), occur. Coupled microscopy, microprobe, and autoradiography studies have determined actual sorption sites for radionuclides on polymineralic rocks. The studies show that it is possible for minor phases to completely dominate the mass of radionuclides adsorbed. The most active minerals are typically alternation products (clays and zeolites). Several exercises are discussed which rank radionuclides according to their potential dose hazards. In each of the analyses discussed, the top four radionuclides are I, Tc, Np, and Ra. Other elements that rank high in potential hazards are Pu, U, Am, Th, Pb, Sn, Pd, and Se

  11. Status of the ATLAS Pixel Detector at the LHC and its performance after three years of operation

    CERN Document Server

    Andreazza, A; The ATLAS collaboration

    2012-01-01

    The ATLAS Pixel Detector is the innermost detector of the ATLAS experiment at the Large Hadron Collider at CERN, providing high-resolution measurements of charged particle tracks in the high radiation environment close to the collision region. This capability is vital for the identification and measurement of proper decay times of long-lived particles such as b-hadrons, and thus vital for the ATLAS physics program. The detector provides hermetic coverage with three cylindrical layers and three layers of forward and backward pixel detectors. It consists of approximately 80 million pixels that are individually read out via chips bump-bonded to 1744 n-in-n silicon substrates. In this talk, results from the successful operation of the Pixel Detector at the LHC and its status after three years of operation will be presented, including monitoring, calibration procedures, timing optimization and detector performance. The detector performance is excellent: ~96 % of the pixels are operational, noise occupancy and hit ...

  12. Pancreatic neuroendocrine tumour (PNET): Staging accuracy of MDCT and its diagnostic performance for the differentiation of PNET with uncommon CT findings from pancreatic adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Hoon; Lee, Jeong Min; Han, Joon Koo; Choi, Byung-Ihn [Seoul National University Hospital, Department of Radiology, 101 Daehangno, Jongno-gu, Seoul (Korea, Republic of); Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul (Korea, Republic of); Eun, Hyo Won [Yonsei University College of Medicine, Department of Radiology, Severance Hospital, Seodaemun-ku, Seoul (Korea, Republic of); Kim, Young Jae [Soonchunhyang University Hospital, Department of Radiology, 657 Hannam-Dong, Youngsan-Ku, Seoul (Korea, Republic of)

    2016-05-15

    To investigate staging accuracy of multidetector CT (MDCT) for pancreatic neuroendocrine tumour (PNET) and diagnostic performance for differentiation of PNET from pancreatic adenocarcinoma. We included 109 patients with surgically proven PNET (NETG1 = 66, NETG2 = 31, NEC = 12) who underwent MDCT. Two reviewers assessed stage and presence of predefined CT findings. We analysed the relationship between CT findings and tumour grade. Using PNETs with uncommon findings, we also estimated the possibility of PNET or adenocarcinoma. Accuracy for T stage was 85-88 % and N-metastasis was 83-89 %. Common findings included well circumscribed, homogeneously enhanced, hypervascular mass, common in lower grade tumours (p < 0.05). Uncommon findings included ill-defined, heterogeneously enhanced, hypovascular mass and duct dilation, common in higher grade tumours (p < 0.05). Using 31 PNETs with uncommon findings, diagnostic performance for differentiation from adenocarcinoma was 0.760-0.806. Duct dilatation was an independent predictor for adenocarcinoma (Exp(B) = 4.569). PNETs with uncommon findings were associated with significantly worse survival versus PNET with common findings (62.7 vs. 95.7 months, p < 0.001). MDCT is useful for preoperative evaluation of PNET; it not only accurately depicts the tumour stage but also prediction of tumour grade, because uncommon findings were more common in higher grade tumours. (orig.)

  13. Composing and Performing in the Key Stage 3 Classroom: A Study using Multi-Trait, Multi-Method Analysis

    Science.gov (United States)

    Fowler, Andrew

    2014-01-01

    "Music is both a creative and a performing art" (Hallam, 2006, p. 70). Many musicians and music educators maintain that composing and performing, although related, are essentially different aspects of musical activity. In the professional musical sphere, composition and performance are almost invariably separated; academic studies have…

  14. Comparison of Performance, Meat Lipids and Oxidative Status of Pigs from Commercial Breed and Organic Crossbreed

    Directory of Open Access Journals (Sweden)

    Giuseppe Martino

    2014-06-01

    Full Text Available The aim of this research was to determine the effect of rearing systems for pig production, as concerns performance, meat lipid content, the fatty acid profile, histidinic antioxidants, coenzyme Q10, and TBARs. One hundred pigs were assigned to one of three treatments: intensively reared commercial hybrid pig (I, free range commercial hybrid pig (FR or organically reared crossbred pig (O, according to organic EU Regulations. I pigs showed the best productive performance, but FR and O increased: C20:1n9, Δ9-desaturase (C18 and thioesterase indices in meat. Lipid, dipeptides and CoQ10 appeared correlated to glycolytic and oxidative metabolic pathways. We can conclude that all studied parameters were influenced by the rearing system used, and that differences were particularly evident in the O system, which produced leaner meat with higher oxidative stability. In this respect, the organic pig rearing system promotes and enhances biodiversity, environmental sustainability and food quality.

  15. Performance and Fabrication Status of TREAT LEU Conversion Conceptual Design Concepts

    Energy Technology Data Exchange (ETDEWEB)

    IJ van Rooyen; SR Morrell; AE Wright; E. P Luther; K Jamison; AL Crawford; HT III Hartman

    2014-10-01

    Resumption of transient testing at the TREAT facility was approved in February 2014 to meet U.S. Department of Energy (DOE) objectives. The National Nuclear Security Administration’s Global Threat Reduction Initiative Convert Program is evaluating conversion of TREAT from its existing highly enriched uranium (HEU) core to a new core containing low enriched uranium (LEU). This paper describes briefly the initial pre-conceptual designs screening decisions with more detailed discussions on current feasibility, qualification and fabrication approaches. Feasible fabrication will be shown for a LEU fuel element assembly that can meet TREAT design, performance, and safety requirements. The statement of feasibility recognizes that further development, analysis, and testing must be completed to refine the conceptual design. Engineering challenges such as cladding oxidation, high temperature material properties, and fuel block fabrication along with neutronics performance, will be highlighted. Preliminary engineering and supply chain evaluation provided confidence that the conceptual designs can be achieved.

  16. Some Observations on the Current Status of Performing Finite Element Analyses

    Science.gov (United States)

    Raju, Ivatury S.; Knight, Norman F., Jr; Shivakumar, Kunigal N.

    2015-01-01

    Aerospace structures are complex high-performance structures. Advances in reliable and efficient computing and modeling tools are enabling analysts to consider complex configurations, build complex finite element models, and perform analysis rapidly. Many of the early career engineers of today are very proficient in the usage of modern computers, computing engines, complex software systems, and visualization tools. These young engineers are becoming increasingly efficient in building complex 3D models of complicated aerospace components. However, the current trends demonstrate blind acceptance of the results of the finite element analysis results. This paper is aimed at raising an awareness of this situation. Examples of the common encounters are presented. To overcome the current trends, some guidelines and suggestions for analysts, senior engineers, and educators are offered.

  17. Research status on aerodynamic interference effects of wind-resistant performance of pylon

    Science.gov (United States)

    LI, Shengli; Lu, Yu; Wang, Dongwei; Chen, Huai

    2011-04-01

    The aerodynamic interference effects of wind-resistant performance for pylon is one of very important problems in numerical simulation studies of wind resistant of bridges. On the basis of looking through a great deal of related literatures at home and abroad, research history, contents, method and achievements of the aerodynamic interference effects are summarized, and the existing problem for galloping, buffeting and vortex-induced vibration of pylon and directions for the next research are pointed out.

  18. Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association with Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis.

    Science.gov (United States)

    Bia, Daniel; Valtuille, Rodolfo; Galli, Cintia; Wray, Sandra; Armentano, Ricardo; Zócalo, Yanina; Cabrera-Fischer, Edmundo

    2017-03-01

    The etiology of the end-stage renal disease (ESRD) and the hydration status may be involved in the arterial stiffening process observed in hemodialyzed patients. The ratio between carotid-femoral and carotid-radial pulse wave velocity (PWV ratio) was recently proposed to characterize the patient-specific stiffening process. to analyze: (1) the PWV-ratio in healthy and hemodialyzed subjects, analyzing potential changes associated to etiologies of the ESRD, (2) the PWV-ratio and hydration status using multiple-frequency bioimpedance and, (3) the effects of hemodialysis on PWV-ratio in a 5-year follow-up. PWV-ratio was evaluated in 151 patients differentiated by the pathology determining their ESRD. Total body fluid (TBF), intra and extra cellular fluid (ICF, ECF) were measured in 65 of these patients using bioelectrical-impedance. The association between arterial, hemodynamic or fluid parameters was analyzed. PWV-ratio was evaluated in a group of patients (n = 25) 5 years later (follow-up study). PWV-ratio increased in the ESRD cohort with respect to the control group (1.03 ± 0.23 vs. 1.31 ± 0.37; p hydration status, but not with the blood pressure. PWV-ratio could be considered a blood pressure-independent parameter, associated with the age and hydration status of the patient.

  19. Current status of design technology on core thermal-hydraulic performance in FLWR

    International Nuclear Information System (INIS)

    Ohnuki, Akira; Kobayashi, Noboru

    2008-01-01

    R and D project to investigate thermal-hydraulic performance in tight-lattice rod bundles for Innovative Water Reactor for Flexible Fuel Cycle (FLWR) has been progressed at Japan Atomic Energy Agency in collaboration with power utilities, reactor vendors and universities. The FLWR adopts a triangular tight-lattice rod bundle with around 1mm gap width between rods and the thermal-hydraulic performance is being recognized as one of the major subjects. We have performed the R and D using large-scale test facility (37-rod bundle with full-height and full-pressure), model experiments and advanced numerical simulation technology. This paper described the master plan for the development of design technology and showed an executive summary for this project. The thermal-hydraulic characteristics in the tight-lattice configuration were investigated and the feasibility was confirmed based on the experiments. We have developed the design technology including subchannel and 3-D numerical simulation one to evaluate the effects of geometry/scale on the thermal-hydraulic behaviors. (author)

  20. Implementation status of performance demonstration program for steam generator tubing analysts in Korea

    International Nuclear Information System (INIS)

    Cho, Chan Hee; Lee, Hee Jong; Yoo, Hyun Ju; Nam, Min Woo; Hong, Sung Yull

    2013-01-01

    Some essential components in nuclear power plants are periodically inspected using non destructive examinations, for example ultrasonic, eddy current and radiographic examinations, in order to determine their integrity. These components include nuclear power plant items such as vessels, containments, piping systems, pumps, valves, tubes and core support structure. Steam generator tubes have an important safety role because they constitute one of the primary barriers between the radioactive and non radioactive sides of the nuclear power plant. There is potential that if a tube bursts while a plant is operating, radioactivity from the primary coolant system could escape directly to the atmosphere. Therefore, in service inspections are critical in maintaining steam generator tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due to its high inspection speed and flaw detectability on non magnetic tubes. However, it is not easy to analyze correctly eddy current signals because they are influenced by many factors. Therefore, the performance of eddy current data analysts for steam generator tubing should be demonstrated comprehensively. In Korea, the performance of steam generator tubing analysts has been demonstrated using the Qualified Data Analyst program. This paper describes the performance demonstration program for steam generator tubing analysts and its implementation results in Korea. The pass rate of domestic analysts for this program was 71.4%

  1. Status of compost usage and its performance on vegetable production in Monga areas of Bangladesh

    Directory of Open Access Journals (Sweden)

    G.K.M.M. Rahman

    2014-12-01

    Full Text Available The present study was carried out to assess the existing status of compost usage on vegetable production and determine the overall effect of household waste compost (HWC on growth and yield of vegetables and enhancement of soil fertility in the monga areas of Bangladesh. A field survey was conducted on 152 sampled farmers during 2010 to 2011. Questionnaire containing both closed and open-ended questions were used to assess existing production practices of vegetables using compost in both homestead and field conditions. Three field trials at Badargonj and Kawnia upazilas of Rangpur district were conducted taking four treatments i.e. control, recommended doses (RD of fertilizers, HWC at the rate of 10 tha-1, and HWC 10 t ha-1 plus RD as IPNS based with Lal shak, Palong shak, Pui shak and Tomato. Base line survey results indicated inadequate knowledge of the farmers on use and preparation of the household waste compost. Yield data of all vegetables i.e. Tomato, Lal shak, Palong shak and Pui shak indicated that the combined application of nutrients using organic and inorganic sources were significantly better than that of solitary application of inorganic fertilizers. The potential of household waste compost applied @ 10 t ha-1 along with inorganic fertilizers applied was found highly satisfactory in producing Tomato, where yield was recorded 75 t ha-1 in the study area. The fresh yield of Palong shak was found 16 t ha-1 when recommended doses of inorganic fertilizers were applied, but it was about 19 t ha-1 under combined application of HWC @ 10 t ha-1 and inorganic fertilizers following IPNS concept. The fresh yield of Pui shak was found about 49 t ha-1 under combined application of organic and inorganic nutrients. Considering the availability and costs of different composts, it is evinced that HWC contained good amount of NPK which indicates its potentiality to be used as a soil amendment, improving soil fertility and crop productivity. It can be

  2. From a Single Presentation of Poetry Up to Its Stylized Stage Image in the Form of Theatre Performance

    Directory of Open Access Journals (Sweden)

    Podmaková Ú Dagmar

    2017-06-01

    Full Text Available In the 1940s the Drama Company of the Slovak National Theatre introduced four poetry productions, which demonstrated the stage potential of the symbiosis of verse and a music-accompanied recitation in an original stage design solution. The single presentation of poetry of Poézia revolúcie a boja [The Poetry of Revolution and Fight, 1945] directed by Ján Jamnický and Pásmo poézie Janka Jesenského [The Show of Poetry by Janko Jesenský, 1946] directed by Jozef Budský were the first independent attempts at staging selected poetry. Besides recitation, they were dominated by the visual sign, powerful music sometimes accompanied by the singing of individuals and a voice band, and distinctive lighting design. Botto’s Smrť Jánošíkova [The Death of Jánošík] and Sládkovič’s Marína (both in 1948 directed by Jozef Budský displayed all features of synthetic theatre, combining recitation, voice band singing, scenic and visual solutions, metaphor, originally composed music inspired by the folk song, dance, film screening, and meaningful lighting. Jozef Budský indirectly built on Czech theatre, particularly on E. F. Burian. Both masterpieces by the authors of Štúr’s generation (Ján Botto, Andrej Sládkovič aroused the interest of the expert public and the audience. It triggered arguments about excessive directorial intervention and insufficient ideological character, especially in the theatre form of Marína.

  3. Performance evaluation of multi-stage filtration with use of granular activated carbon and synthetic non-woven fabrics

    OpenAIRE

    Tangerino, Edson Pereira; Rosa Araujo, Laryssa Melo [UNESP; Borges, Rivea Medri [UNESP; Sanchez Ortiz, Ivan Andres [UNESP

    2013-01-01

    The multi stage filtration (MSF) is an alternative that permits to enlarge the spectrum of application of the slow sand filtration as for the effluent quality and run duration. In this research the use of MSF technology associated to a granular activated carbon (GAC) column as polishing mechanism of the final effluent was evaluated; in the slow sand filters GAC was used as an intermediate layer and non-woven synthetic fabrics were utilized as a first layer of the filter media. Five different ...

  4. The nutritional status of continuous ambulatory peritoneal dialysis ...

    African Journals Online (AJOL)

    Objectives: To assess the nutritional status of continuous ambulatory peritoneal dialysis (CAPD) patients in our hospital using different assessment tools, and to assess the correlation between nutritional status and other parameters such as solute clearance. Method: A cross-sectional study was performed on end-stage ...

  5. Distinguishing Playing Status Through a Functionally Relevant Performance Measure in Female Division I Collegiate Soccer Athletes.

    Science.gov (United States)

    Magrini, Mitchel A; Colquhoun, Ryan J; Sellers, John H; Conchola, Eric C; Hester, Garrett M; Thiele, Ryan M; Pope, Zach K; Smith, Doug B

    2017-06-08

    Although soccer is predominately an endurance sport, high velocity movements may be an important indicator of athletic success. The purpose of this investigation was to establish whether squat jumps (SJ) can differentiate starters from non-starters with a female collegiate division I soccer team. Eighteen female division I soccer athletes were separated into two groups: 9 starters (age: 19.5 ± 1.0; mass = 64.8 ± 11.5 kg; height = 167.5 ± 7.7 cm; games started = 18.2 ± 4.7; minutes played = 1633.8 ± 478.2 min) and 9 non-starters (age: 19.4 ± 1.4 years; mass = 63.3 ± 4.2 kg; height = 164.7 ± 6.8 cm; games started 0.7 ± 1.3; minutes played 158.2 ± 269.3). Each athlete performed 3 maximal SJs at a starting knee angle of 110° without arm swing. Each participant's SJ height, mean power (MP), peak power (PP), mean velocity (MV), and peak velocity (PV) were measured during each attempt by a linear position transducer (LPT). No statistically significant differences (p ≥ 0.05) in MP and PP between the starters and non-starters were observed. However, starters performed significantly better than non-starters in SJ height (p = 0.002), MV (p = 0.025), and PV (p = 0.015). Additionally, SJ height was strongly correlated with MV (r = 0.628) and PV (r = 0.647). These findings suggest that SJ height, MV and PV, may be important variables for discriminating differences between starters and non-starters in division I female soccer athletes and a strong indicator of explosive performance.

  6. Voluntary fluid intake, hydration status, and aerobic performance of adolescent athletes in the heat.

    Science.gov (United States)

    Wilk, Boguslaw; Timmons, Brian W; Bar-Or, Oded

    2010-12-01

    We determined whether beverage flavoring and composition would stimulate voluntary drink intake, prevent dehydration, and maintain exercise performance in heat-acclimated adolescent males running in the heat. Eight adolescent (age, 13.7 ± 1.1 years) runners (peak oxygen uptake, 59.5 ± 4.0 mL·kg-1·min-1) underwent at least four 80-min exercise heat-acclimation sessions before completing 3 experimental sessions. All sessions were performed at 30 °C and 60%-65% relative humidity. Each experimental session consisted of five 15-min treadmill runs at a speed eliciting 65% peak oxygen uptake, with a 5 min rest prior to each run. Ten minutes after the final run, a time to exhaustion test was performed at a speed eliciting 90% peak oxygen uptake. Counterbalanced experimental sessions were identical, except for fluid intake, which consisted of tap water (W), flavored water (FW), and FW with 6% carbohydrate and 18 mmol·L-1 NaCl (CNa) consumed ad libitum. Fluid intake and body weight were monitored to calculate dehydration. Voluntary fluid intake was similar to fluid losses in W (1032 ± 130 vs. 1340 ± 246 g), FW (1086 ± 86 vs. 1451 ± 253 g), and CNa (1259 ± 119 vs. 1358 ± 234 g). As a result, significant dehydration was avoided in all trials (-0.45% ± 0.68% body weight in W, -0.66% ± 0.50% body weight in FW, and -0.13% ± 0.71% body weight in CNa). Core temperature increased by ~1 °C during exercise, but was not different between trials. Time to exhaustion was not different between trials and averaged 8.8 ± 1.7 min. Under exercise conditions more closely reflecting real-life situations, heat-acclimatized adolescent male runners can appropriately gauge fluid intake regardless of the type of beverage made available, resulting in consistency in exercise performance.

  7. Electro-optic correlator for large-format microwave interferometry: Up-conversion and correlation stages performance analysis

    Science.gov (United States)

    Ortiz, D.; Casas, Francisco J.; Ruiz-Lombera, R.; Mirapeix, J.

    2017-04-01

    In this paper, a microwave interferometer prototype with a near-infra-red optical correlator is proposed as a solution to get a large-format interferometer with hundreds of receivers for radio astronomy applications. A 10 Gbits/s Lithium Niobate modulator has been tested as part of an electro-optic correlator up-conversion stage that will be integrated in the interferometer prototype. Its internal circuitry consists of a single-drive modulator biased by a SubMiniature version A (SMA) connector allowing to up-convert microwave signals with bandwidths up to 12.5 GHz to the near infrared band. In order to characterize it, a 12 GHz tone and a bias voltage were applied to the SMA input using a polarization tee. Two different experimental techniques to stabilize the modulator operation point in its minimum optical carrier output power are described. The best achieved results showed a rather stable spectrum in amplitude and wavelength at the output of the modulator with an optical carrier level 23 dB lower than the signal of interest. On the other hand, preliminary measurements were made to analyze the correlation stage, using 4f and 6f optical configurations to characterize both the antenna/fiber array configuration and the corresponding point spread function.

  8. Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group

    Energy Technology Data Exchange (ETDEWEB)

    Servaes, Sabah [Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); Khanna, Geetika [Washington University School of Medicine, Pediatric Radiology, St. Louis Children' s Hospital, Mallinckrodt Institute for Radiology, 510 S. Kingshighway, Campus Box 8131-MIR, St. Louis, MO (United States); Naranjo, Arlene [University of Florida, Department of Biostatistics, Gainesville, FL (United States); Geller, James I. [Cincinnati Children' s Hospital Medical Center, Division of Oncology, Cincinnati, OH (United States); Ehrlich, Peter F. [University of Michigan, Department of Surgery, C.S. Mott Children' s Hospital, Ann Arbor, MI (United States); Gow, Kenneth W. [Seattle Children' s Hospital, Pediatric Surgery, Seattle, WA (United States); Perlman, Elizabeth J. [Ann and Robert H. Lurie Children' s Hospital of Chicago, Department of Pathology, Chicago, IL (United States); Dome, Jeffrey S. [Children' s National Medical Center, Center for Cancer and Blood Disorders, Washington, DC (United States); Gratias, Eric; Mullen, Elizabeth A. [Harvard University, Dana Farber Cancer Institute and Boston Children' s Hospital, Boston, MA (United States)

    2014-08-19

    CT and MRI are both used for abdominal staging of pediatric renal tumors. The diagnostic performance of the two modalities for local and regional staging of renal tumors has not been systematically evaluated. To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumors. The study population was derived from the AREN03B2 study of the Children's Oncology Group. Baseline abdominal imaging performed with both CT and MRI within 30 days of nephrectomy was available for retrospective review in 82 renal tumor cases. Each case was evaluated for capsular penetration, lymph node metastasis, tumor thrombus, preoperative tumor rupture, and synchronous contralateral lesions. The surgical and pathological findings at central review were the reference standard. The sensitivity of CT and MRI for detecting capsular penetration was 68.6% and 62.9%, respectively (P = 0.73), while specificity was 86.5% and 83.8% (P = 1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 76.5% and 52.9% (P = 0.22), and specificity was 90.4% and 92.3% (P = 1.0). Synchronous contralateral lesions were identified by CT in 4/9 cases and by MRI in 7/9 cases. CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MR detected more contralateral synchronous lesions; however these were present in a very small number of cases. Either modality can be used for initial loco-regional staging of pediatric renal tumors. (orig.)

  9. Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group

    International Nuclear Information System (INIS)

    Servaes, Sabah; Khanna, Geetika; Naranjo, Arlene; Geller, James I.; Ehrlich, Peter F.; Gow, Kenneth W.; Perlman, Elizabeth J.; Dome, Jeffrey S.; Gratias, Eric; Mullen, Elizabeth A.

    2015-01-01

    CT and MRI are both used for abdominal staging of pediatric renal tumors. The diagnostic performance of the two modalities for local and regional staging of renal tumors has not been systematically evaluated. To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumors. The study population was derived from the AREN03B2 study of the Children's Oncology Group. Baseline abdominal imaging performed with both CT and MRI within 30 days of nephrectomy was available for retrospective review in 82 renal tumor cases. Each case was evaluated for capsular penetration, lymph node metastasis, tumor thrombus, preoperative tumor rupture, and synchronous contralateral lesions. The surgical and pathological findings at central review were the reference standard. The sensitivity of CT and MRI for detecting capsular penetration was 68.6% and 62.9%, respectively (P = 0.73), while specificity was 86.5% and 83.8% (P = 1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 76.5% and 52.9% (P = 0.22), and specificity was 90.4% and 92.3% (P = 1.0). Synchronous contralateral lesions were identified by CT in 4/9 cases and by MRI in 7/9 cases. CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MR detected more contralateral synchronous lesions; however these were present in a very small number of cases. Either modality can be used for initial loco-regional staging of pediatric renal tumors. (orig.)

  10. Eleventh interim status report: Model 9975 O-Ring fixture long-term leak performance

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-08-01

    A series of experiments to monitor the aging performance of Viton® GLT O-rings used in the Model 9975 package has been ongoing since 2004 at the Savannah River National Laboratory. One approach has been to periodically evaluate the leak performance of O-rings being aged in mock-up 9975 Primary Containment Vessels (PCVs) at elevated temperature. Other methods such as compression-stress relaxation (CSR) tests and field surveillance are also on-going to evaluate O-ring behavior. Seventy tests using PCV mock-ups were assembled and heated to temperatures ranging from 200 to 450 ºF. They were leak-tested initially and have been tested periodically to determine if they continue to meet the leak-tightness criterion defined in ANSI standard N14.5-97. Due to material substitution, fourteen additional tests were initiated in 2008 with GLT-S O-rings heated to temperatures ranging from 200 to 400 ºF.

  11. The LHCb RICH system: current detector performance and status of the upgrade program

    CERN Document Server

    Fiorini, Massimiliano

    2016-01-01

    LHCb is a precision experiment devoted to the study of CP violation and rare decays of b and c quarks, and to the search for new physics beyond the Standard Model at the Large Hadron Collider (LHC) at CERN. The Ring-Imaging Cherenkov (RICH) system is a key component of the LHCb experiment: it consists of two RICH detectors that provide charged particle identification over a wide momentum range (2-100 GeV/c) and angular acceptance (15-300 mrad). The LHCb RICH system has been performing extremely well during Run 1 and is providing the LHCb experiment also in Run 2 with a robust, reliable and precise particle identification system. Performance of the RICH detectors measured from data will be presented, with special reference to its dependence on calibration parameters and event multiplicities. The LHCb experiment is preparing for an upgrade during the second LHC long shutdown (2019-2020) in order to fully exploit the LHC flavour physics potential. A five-fold increase in instantaneous luminosity is foreseen reac...

  12. Ergogenic aids: a review of basic science, performance, side effects, and status in sports.

    Science.gov (United States)

    Tokish, John M; Kocher, Mininder S; Hawkins, Richard J

    2004-09-01

    The use of drugs and supplements to enhance performance has become a part of mainstream athletics. Many team physicians and sports medicine practitioners are unfamiliar with the benefits and risks of these products and thus are unable to educate young athletes on this topic. In spite of numerous reports on the health risks of anabolic steroid use, 1 to 3 million Americans have used them. Human growth hormone has been tried by up to 5% of 10th graders, although no scientific study has shown that it is an effective performance-enhancing drug. Amphetamines and similar compounds may be the most widely abused drug in baseball; recently, they have come under increased scrutiny in sport. Erythropoietin is a highly effective aerobic enhancer that has been linked to multiple deaths in cyclists and other endurance athletes. The neutraceutical industry, led by supplements such as creatine, ephedra, and androstenedione, remains unregulated by the Food and Drug Administration and has serious issues with quality and side effects. An understanding of these products is essential for the sports medicine practitioner to provide sound, safe advice to the athlete.

  13. Effects of catechins on litter size, reproductive performance and antioxidative status in gestating sows

    Directory of Open Access Journals (Sweden)

    Zhiyong Fan

    2015-12-01

    Full Text Available This study was conducted to investigate the effects of catechins on reproductive performance, antioxidative capacity and immune function of gestating sows. A total of 60 cross-bred (Landrace × Large White multiparious sows were blocked by body weight, parity and backfact and randomly allocated to 1 of 5 treatments: 0, 100, 200, 300, or 400 mg/kg catechins. Dietary treatments were imposed from mating to d 40 of gestation of sows. At farrowing, litter total born, born alive, dead, and normal-(healthy piglets, ≥0.85 kg and low-birth weight piglets ( 0.05. Sows received 200 mg catechin per kg diets showed a reduction (P < 0.05 of the serum MDA level at farrowing compared with all other treatments. Sows received all the levels of catechin showed a reduction (P < 0.05 of serum H2O2 level compared with sows received the control diet on both d 40 of gestation and farrowing. Our results demonstrated that the catechins may be a potential antioxidant to increase the reproductive performance and antioxidative capacity of sows when it was added into diets during the early gestation.

  14. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance

    Science.gov (United States)

    Boyett, James C.; Giersch, Gabrielle E. W.; Womack, Christopher J.; Saunders, Michael J.; Hughey, Christine A.; Daley, Hannah M.; Luden, Nicholas D.

    2016-01-01

    This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg−1·min−1) were divided into tertiles based on training levels, with top and bottom tertiles designated as ‘trained’ (n = 7) and ‘untrained’ (n = 7). Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling time trial (TT). The trials were performed in randomized order for each combination of time of day (morning and evening) and treatment (6mg/kg of caffeine or placebo). Magnitude-based inferences were used to evaluate all treatment effects. For all subjects, caffeine enhanced TT performance in the morning (2.3% ± 1.7%, ‘very likely’) and evening (1.4% ± 1.1%, ‘likely’). Both untrained and trained subjects improved performance with caffeine supplementation in the morning (5.5% ± 4.3%, ‘likely’; 1.0% ± 1.7%, ‘likely’, respectively), but only untrained subjects rode faster in the evening (2.9% ± 2.6%, ‘likely’). Altogether, our observations indicate that trained athletes are more likely to derive ergogenic effects from caffeine in the morning than the evening. Further, untrained individuals appear to receive larger gains from caffeine in the evening than their trained counterparts. PMID:27754419

  15. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance

    Directory of Open Access Journals (Sweden)

    James C. Boyett

    2016-10-01

    Full Text Available This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg−1·min−1 were divided into tertiles based on training levels, with top and bottom tertiles designated as ‘trained’ (n = 7 and ‘untrained’ (n = 7. Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling time trial (TT. The trials were performed in randomized order for each combination of time of day (morning and evening and treatment (6mg/kg of caffeine or placebo. Magnitude-based inferences were used to evaluate all treatment effects. For all subjects, caffeine enhanced TT performance in the morning (2.3% ± 1.7%, ‘very likely’ and evening (1.4% ± 1.1%, ‘likely’. Both untrained and trained subjects improved performance with caffeine supplementation in the morning (5.5% ± 4.3%, ‘likely’; 1.0% ± 1.7%, ‘likely’, respectively, but only untrained subjects rode faster in the evening (2.9% ± 2.6%, ‘likely’. Altogether, our observations indicate that trained athletes are more likely to derive ergogenic effects from caffeine in the morning than the evening. Further, untrained individuals appear to receive larger gains from caffeine in the evening than their trained counterparts.

  16. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance.

    Science.gov (United States)

    Boyett, James C; Giersch, Gabrielle E W; Womack, Christopher J; Saunders, Michael J; Hughey, Christine A; Daley, Hannah M; Luden, Nicholas D

    2016-10-14

    This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg -1 ·min -1 ) were divided into tertiles based on training levels, with top and bottom tertiles designated as 'trained' ( n = 7) and 'untrained' ( n = 7). Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling time trial (TT). The trials were performed in randomized order for each combination of time of day (morning and evening) and treatment (6mg/kg of caffeine or placebo). Magnitude-based inferences were used to evaluate all treatment effects. For all subjects, caffeine enhanced TT performance in the morning (2.3% ± 1.7%, 'very likely') and evening (1.4% ± 1.1%, 'likely'). Both untrained and trained subjects improved performance with caffeine supplementation in the morning (5.5% ± 4.3%, 'likely'; 1.0% ± 1.7%, 'likely', respectively), but only untrained subjects rode faster in the evening (2.9% ± 2.6%, 'likely'). Altogether, our observations indicate that trained athletes are more likely to derive ergogenic effects from caffeine in the morning than the evening. Further, untrained individuals appear to receive larger gains from caffeine in the evening than their trained counterparts.

  17. Status of the ATLAS Pixel Detector and its performance after three years of operation

    CERN Document Server

    Favareto, A; The ATLAS collaboration

    2012-01-01

    The ATLAS Pixel Detector is the innermost detector of the ATLAS experiment at the Large Hadron Collider at CERN, providing high-resolution measurements of charged particle tracks in the high radiation environment close to the collision region. This capability is very important for the identification and measurement of proper decay times of long-lived particles such as b-hadrons, and thus vital for the ATLAS physics program. The detector provides hermetic coverage with three cylindrical layers and three layers of forward and backward pixel detectors. It consists of approximately 80 million pixels that are individually read out via chips bump-bonded to 1744 n-in-n silicon substrates. The detector performance is excellent: ~96 % of the pixels are operational, noise occupancy and hit efficiency exceed the design specification, and a good alignment allows high quality track resolution

  18. Status of the ATLAS Pixel Detector and its performance after three years of operation

    CERN Document Server

    Favareto, A; The ATLAS collaboration

    2012-01-01

    The ATLAS Pixel Detector is the innermost detector of the ATLAS experiment at the Large Hadron Collider at CERN, providing high-resolution measurements of charged particle tracks in the high radiation environment close to the collision region. This capability is very important for the identification and measurement of proper decay times of long-lived particles such as b-hadrons, and thus vital for the ATLAS physics program. The detector provides hermetic coverage with three cylindrical layers and three layers of forward and backward pixel detectors. It consists of approximately 80 million pixels that are individually read out via chips bump-bonded to 1744 n-in-n silicon substrates. The detector performance is excellent: ~96% of the pixels are operational, noise occupancy and hit efficiency exceed the design specification, and a good alignment allows high quality track resolution.

  19. Status of assessment tools on the performance guarantee contents of backfill, bulkhead, tunnel and pit

    International Nuclear Information System (INIS)

    Kawakami, Susumu; Fujita, Tomoo; Yui, Mikazu

    2006-03-01

    In order to contribute to the safety standards and guidelines which a regulator will decide, a state-of-the-art assessment method is investigated and summarized in tables about performance guarantee contents of backfill, bulkhead, tunnel (access, main, connecting, disposal) and disposal pit. In addition, examples of assessment tools are described. In this report, summary of (1) basic properties of bentonite, including swelling, mechanical and hydraulic properties, (2) long-term behavior of bentonite, including extrusion/erosion into host rock, and alteration, (3) effect of high pH plume from cementitious material and (4) mechanical stability of the near-field is described. Check points, assessment methods for (based on the data obtained from the experimental results, the estimation value obtained from empirical equations and database, and the modeling calculations) and latest results of these R and D programs were also summarized. (author)

  20. Dietary Supplementation of Phoenix dactylifera Seeds Enhances Performance, Immune Response, and Antioxidant Status in Broilers

    Science.gov (United States)

    El-Far, Ali H.; Ahmed, Hamada A.

    2016-01-01

    The date palm (Phoenix dactylifera) seeds were utilized in some traditional medical remedies and have been investigated for their possible health benefits. This proposed study wanted to assess the effect of date palm seeds (DPS) dietary supplementation in comparison to mannan-oligosaccharides (Bio-Mos®) and β-glucan over antioxidant and immunity events that have effect on growth and carcass performances of broilers. An aggregate of 180, one-day-old, chicks were raised in the wire-floored cages and allotted into control, Bio-Mos (0.1%  Bio-Mos), β-glucan (0.1%  β-glucan), DPS2 (2% date crushed seeds), DPS4 (4% date crushed seeds), and DPS6 (6% date crushed seeds) groups. Broilers in DPS2 and DPS4 groups showed significant variations (P dactylifera seeds. PMID:28127417

  1. THE EFFECT OF DIETARY SUPPLEMENTATION OF HERBAL EXTRACTS ON GROWTH PERFORMANCE AND HEALTH STATUS OF RABBITS

    Directory of Open Access Journals (Sweden)

    Mária Chrenková

    2013-02-01

    Full Text Available Seventy two rabbits (Hycole, (♂+♀ 5 weeks old were divided into 2 experimental (EG and one control (CG group. The feed mixture A in control (CG did not contain any coccidiostat. In the first experimental group (EG1 was tested a complete granulated mixture B enriched with 30 g dry extract Eleutherococcus senticosus per 100 kg mixture. The animals were fed mixture B in combination with probiotic strain Enterococcus faecium EF AL 41 applied orally at a dose (10 9 CFU. ml-1 500 μl per animal in drinking water during 21 days. In the second group (EG2 was tested complete granulated mixture B. The experiment lasted 42 days. Body weight and feed consumption were registered weekly. Samples of faeces were taken at days 1, 21 and 42 to monitor the counts and effect of natural substances. Blood samples were also taken to check biochemical parameters using commercial kits. The samples for microbiological analyses were treated by the standard microbiological method according to ISO with appropriate media. Results presented in this study introduce different mechanisms of action for different classes of feed additives and how these may influence the observed live performance benefits. Application of Eleutherococcus extract in combination with EF AL 41 strain in rabbits was beneficial for performance. Additives reduced counts of S. aureus and Clostridium-like sp in faeces. Bioactive substances can be beneficial for animal health as was repeatedly confirmed by our results (mortality in EG1- 12%, EG2 - 8% compared to CG- 17%.

  2. Weight Status and Differences in Mobility Performance, Pain Symptoms, and Physical Activity in Older, Knee Osteoarthritis Patients

    Directory of Open Access Journals (Sweden)

    Matthew J. Garver

    2014-01-01

    Full Text Available Knee osteoarthritis (OA is a leading cause of functional disability among American adults. Obesity is a strong independent risk factor for OA. While research emphasizes the role of obesity in the OA-physical function relationship, the extent to which weight status impacts salient physical, health, and pain measures in older, knee OA patients is not well delineated. The primary aim of this study was to assess differences in mobility performance (stair climb and 400-meter walk, mobility-related self-efficacy, pain symptoms (WOMAC, and measures of accelerometer-determined physical activity (PA as a function of weight status. Analysis of covariance was conducted to examine differences on the dependent variables. Obese class III patients were outperformed by their counterparts on nearly every measure of mobility, mobility-related self-efficacy, and the assessment of pain symptoms. These outcomes did not differ among other weight comparisons. Normal weight subjects outperformed classes I, II, and III counterparts on most measures of PA (engagement in moderate or greater PA and total weekly steps. Additionally, overweight participants outperformed obese class II participants and obese class I participants outperformed obese classes II and III participants on total weekly steps. Collectively, these findings underscore the meaningful differences observed in relevant OA outcomes as a function of increasing levels of body weight.

  3. Performance comparison of machine learning methods for prognosis of hormone receptor status in breast cancer tissue samples.

    Science.gov (United States)

    Kalinli, Adem; Sarikoc, Fatih; Akgun, Hulya; Ozturk, Figen

    2013-06-01

    We examined the classification and prognostic scoring performances of several computer methods on different feature sets to obtain objective and reproducible analysis of estrogen receptor status in breast cancer tissue samples. Radial basis function network, k-nearest neighborhood search, support vector machines, naive bayes, functional trees, and k-means clustering algorithm were applied to the test datasets. Several features were employed and the classification accuracies of each method for these features were examined. The assessment results of the methods on test images were also experimentally compared with those of two experts. According to the results of our experimental work, a combination of functional trees and the naive bayes classifier gave the best prognostic scores indicating very good kappa agreement values (κ=0.899 and κ=0.949, p<0.001) with the experts. This combination also gave the best dichotomization rate (96.3%) for assessment of estrogen receptor status. Wavelet color features provided better classification accuracy than Laws texture energy and co-occurrence matrix features. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  4. Personality characteristics and affective status related to cognitive test performance and gender in patients with memory complaints.

    Science.gov (United States)

    Vestberg, Susanna; Passant, Ulla; Risberg, Jarl; Elfgren, Christina

    2007-11-01

    The aims are to study personality characteristics of patients with memory complaints and to assess the presence of objective (OMI) versus subjective (SMI) memory impairment, the affective status, as well as potential gender differences. The patients were assessed by means of a neuropsychiatric examination and a neuropsychological test-battery. The Swedish version of the revised NEO Personality Inventory (NEO PI-R) and the Hospital Anxiety and Depression Scale (HADS) were used. The 57 patients (38 women, 19 men, mean age 56.9) differed from the Swedish normative group in three of the five personality factors: neuroticism, extraversion and agreeableness. This was mainly because of the scores of the female patients. Approximately half of the patients had OMI. No differences regarding personality factors or affective status were found between OMI and SMI patients. The female patients scored significantly higher than the male patients on symptoms of anxiety and depression. Neuroticism and symptoms of depression interacted with memory performance and gender. Our findings demonstrate the importance of applying an objective assessment of memory functions and a gender perspective when studying patients with memory complaints.

  5. Is the performance of MRI in preoperative staging of breast cancer independent of clinical and histological factors? A subgroup analysis.

    Science.gov (United States)

    Carreira Gómez, C; Zamora Romero, J; Gil de Miguel, A; Chiva de Agustín, M; Plana Farrás, M N; Martínez González, J

    2015-01-01

    To determine whether preoperative breast MRI is more useful in patients according to their breast density, age, menopausal status, and biopsy findings of carcinoma in situ. We retrospectively studied 264 patients treated for breast cancer who had undergone mammography, ultrasonography, and MRI. We compared the size of the tumor on the three techniques and the sensitivity of the techniques for detecting additional lesions both in the overall group and in subgroups of patients classified according to their breast density, age, menopausal status, and histological findings of intraductal carcinoma. The definitive histological diagnosis was used as the gold standard. MRI was the technique that was most concordant with the histological findings for the size of the lesion, and it was also the technique that detected the most additional lesions. With MRI, we observed no differences in lesion size between the overall group and the subgroups in which MRI provided added value. Likewise, we observed no differences in the number of additional lesions detected in the overall group except for multicentric lesions, which was larger in older patients (P=.02). In the subgroup of patients in which MRI provided added value, the sensitivity for bilateral lesions was higher in patients with fatty breasts (P=.04). Multifocal lesions were detected significantly better in premenopausal patients (P=.03). MRI is better than mammography and better than ultrasonography for establishing the size of the tumor and for detecting additional lesions. Our results did not identify any subgroups in which the technique was more useful. Copyright © 2013 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  6. Performance of self-reported HIV status in determining true HIV status among older adults in rural South Africa: a validation study.

    Science.gov (United States)

    Rohr, Julia K; Xavier Gómez-Olivé, F; Rosenberg, Molly; Manne-Goehler, Jennifer; Geldsetzer, Pascal; Wagner, Ryan G; Houle, Brian; Salomon, Joshua A; Kahn, Kathleen; Tollman, Stephen; Berkman, Lisa; Bärnighausen, Till

    2017-07-18

    In South Africa, older adults make up a growing proportion of people living with HIV. HIV programmes are likely to reach older South Africans in home-based interventions where testing is not always feasible. We evaluate the accuracy of self-reported HIV status, which may provide useful information for targeting interventions or offer an alternative to biomarker testing. Data were taken from the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) baseline survey, which was conducted in rural Mpumalanga province, South Africa. A total of 5059 participants aged ≥40 years were interviewed from 2014 to 2015. Self-reported HIV status and dried bloodspots for HIV biomarker testing were obtained during at-home interviews. We calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for self-reported status compared to "gold standard" biomarker results. Log-binomial regression explored associations between demographic characteristics, antiretroviral therapy (ART) status and sensitivity of self-report. Most participants (93%) consented to biomarker testing. Of those with biomarker results, 50.9% reported knowing their HIV status and accurately reported it. PPV of self-report was 94.1% (95% confidence interval (CI): 92.0-96.0), NPV was 87.2% (95% CI: 86.2-88.2), sensitivity was 51.2% (95% CI: 48.2-54.3) and specificity was 99.0% (95% CI: 98.7-99.4). Participants on ART were more likely to report their HIV-positive status, and participants reporting false-negatives were more likely to have older HIV tests. The majority of participants were willing to share their HIV status. False-negative reports were largely explained by lack of testing, suggesting HIV stigma is retreating in this setting, and that expansion of HIV testing and retesting is still needed in this population. In HIV interventions where testing is not possible, self-reported status should be considered as a routine

  7. Performance, costs, and GHG emissions of PV-hybrid systems : current status and avenues for improvement

    Energy Technology Data Exchange (ETDEWEB)

    Ross, M.M.D. [RER Renewable Energy Research, Montreal, PQ (Canada)

    2007-07-01

    The performance of a baseline 300 W photovoltaic (PV) hybrid system was investigated and compared with a prime power system, a genset battery system, and a PV-battery system. The analysis considered initial and annual costs, energy production, and greenhouse gas (GHG) emissions. An economic analysis of the overall life-cycle cost of the systems was provided. Simulations were used to determine system performance in both residential areas and in a remote off-grid industrial scenario. Hourly monitored weather data for a 5 year period in various Canadian cities were used to simulate 6 different PV-hybrid system configurations, namely 14 genset-battery configurations, 2 prime power configurations, and a stand-alone PV-battery system. A battery with 2 days of autonomy was used for both the genset battery and the PV hybrid system. The prime power system consisted of a 5 kW diesel genset and a rectifier with a 92.5 per cent efficiency at 50 W. The PV array was designed to achieve an annual solar fraction of 65 per cent. Data collected from a GNB Absolyte IIP absorbent glass mat batter was used to characterize the current-voltage behaviour of the battery model. The study considered battery capacity deterioration, fractions of solar energy wasted, as well as the fraction of wasted energy that could be avoided through the use of non-seasonal storage. The overall cost of generating electricity was calculated by considering equivalent annual costs divided by the electrical energy required annually. Results of the analysis indicated that prime power systems were not suitable for remote, industrial applications. Results of the residential analysis indicated that the PV-battery system was less economically viable than either the genset-battery or the PV hybrid system. The higher fuel consumption of the genset-battery system resulted in greenhouse gas emissions that were 3 times as high as those observed with the hybrid system, which generated 0.9 tonnes of carbon dioxide

  8. Benchmarking energy performance of residential buildings using two-stage multifactor data envelopment analysis with degree-day based simple-normalization approach

    International Nuclear Information System (INIS)

    Wang, Endong; Shen, Zhigang; Alp, Neslihan; Barry, Nate

    2015-01-01

    Highlights: • Two-stage DEA model is developed to benchmark building energy efficiency. • Degree-day based simple normalization is used to neutralize the climatic noise. • Results of a real case study validated the benefits of this new model. - Abstract: Being able to identify detailed meta factors of energy performance is essential for creating effective residential energy-retrofitting strategies. Compared to other benchmarking methods, nonparametric multifactor DEA (data envelopment analysis) is capable of discriminating scale factors from management factors to reveal more details to better guide retrofitting practices. A two-stage DEA energy benchmarking method is proposed in this paper. This method includes (1) first-stage meta DEA which integrates the common degree day metrics for neutralizing noise energy effects of exogenous climatic variables; and (2) second-stage Tobit regression for further detailed efficiency analysis. A case study involving 3-year longitudinal panel data of 189 residential buildings indicated the proposed method has advantages over existing methods in terms of its efficiency in data processing and results interpretation. The results of the case study also demonstrated high consistency with existing linear regression based DEA.

  9. The Effects of Two Different Cleaning and Disinfection Programs on Broiler Performance and Microbiological Status of Broiler Houses

    Directory of Open Access Journals (Sweden)

    MFC Burbarelli

    2015-12-01

    Full Text Available ABSTRACT The objective of this study was to investigate the influence of two cleaning and disinfection programs on broiler performance and on the microbiological status of the facilities. This trial was an observational study of comparative character. Two experiments were conducted, with 960 birds each. Both experiments were carried out in a positive-pressure broiler house. Broilers were distributed in pens equipped with a bell drinker and a tube feeder each. In the first experiment, new wood shavings were used as litter material, and in the second, reused wood shavings were used. Two treatments with16 replicates of 30 birds each were evaluated. The regular treatment consisted of dry and wet organic matter removal, followed by washing. The European treatment consisted of dry organic matter removal, humidification, washing with water under high pressure, detergent application, rinsing, and application of two combined disinfectants: glutaraldehyde 250g/L + formaldehyde 185g/L; p-chlor-m-cresol 210 g/L. Biosecurity measures were adopted during daily management tasks to prevent cross contamination between treatments. The effectiveness of the treatments was evaluated by microbiological analysis performed before and after treatment applications, as well as by broiler performance results. Live performance results were similar between both treatments when broilers were reared on new litter. When reused word-shavings were used as litter material, the European treatment promoted better broiler performance. The European treatment was more effective than the regular treatment in reducing total microbial counts in the facilities when reused wood shavings were used as litter material, and positively influenced broiler performance.

  10. Status and performance of the CMS muon system in Run2

    CERN Document Server

    Cabrera Mora, Andres Leonardo

    2016-01-01

    The CMS muon system has played a key role for many physics results obtained from the LHC Run1 and Run2 data. During the Long Shutdown (2013-2014), as well as during the last year-end technical stop (2015-2016), significant consolidation and upgrades have been carried out on the muon detectors and on the Level-1 (L1) muon trigger. The algorithms for muon reconstruction and identification have also been improved for both the High-Level Trigger (HLT) and the offline reconstruction. Results of the performance of muon detectors, reconstruction and trigger, obtained using data collected at 13 TeV center-of-mass energy during the 2015 and 2016 LHC runs, are presented. Comparison of simulation with experimental data is also discussed where relevant. The system's state of the art is also shown, as well the improvements foreseen to achieve excellent overall quality of muon reconstruction in the high-luminosity conditions expected during Run2.

  11. Equipment performance and radiation protection status in X-ray fluoroscopy units in Sudan

    International Nuclear Information System (INIS)

    Ahmed, N. A.; Nayl, A. I.; Suliman, I. I.

    2012-01-01

    The number of fluoroscopy and fluoroscopically guided procedures has been substantially growing in developing countries at the same time advanced and sophisticated equipment are used in some hospitals. However, radiation protection requirements are not necessarily well adopted. In this study nine fluoroscopy X-ray units in Sudan were examined for compliance with international standards. The tests included: beam quality, entrance surface air kerma, image quality and radiation field measurements. Staff radiation protection tools such as lead aprons and eye glasses were also visually examined to find out whether international recommendations were fulfilled and to determine the level of staff awareness. The measured peak tube voltage deviation exceeded the recommended tolerance level in 30 % of the measurements. The results of patient doses measurements exceeded the recommended reference dose levels in 43 % of the measurements; however image quality and radiation field generally fulfilled the requirements for most units. The study revealed that a considerable number of fluoroscopy units were not performing according to the international standards and highlights the need of optimisation of radiation protection. (authors)

  12. Status report on performance of radioisotope thermoelectric generators using silicon germanium thermoelectric elements

    International Nuclear Information System (INIS)

    Bennett, G.L.; Campbell, R.W.; Putnam, L.R.; Hemler, R.J.

    1994-01-01

    Three general-purpose heat source radioisotope thermoelectric generators (GPHS-RTGs) are currently in use in space: two on board the Galileo spacecraft on its way to Jupiter and one on the Ulysses spacecraft exploring the polar regions of the Sun. The GPHS-RTG was designed to provide at least 285 W(e) at the beginning of mission (BOM) within a mass constraint of 56 kg and an overall size envelope of 42.2 cm in diameter and 114 cm in length. The Galileo spacecraft, which as already sent back exciting scientific information on Venus, Earth, and the asteroids Gaspra and Ida, carries two GPHS-RTGs which operate at 30 V. The Ulysses spacecraft, which has already successfully swung past Jupiter on its way to the southern polar regions of the Sun, carries one GPHS-RTG which operates at 28 V. The analyses presented in the paper show that both Galileo and Ulysses will have sufficient power for the baseline missions and analyses are under way to determine the power available for an extended Ulysses mission out to the year 2002. Ten other silicon-germanium-based RTGs on the LES 8/9 and Voyager 1/2 spacecraft have completed their prime missions and are now successfully performing extended missions

  13. Breakfast habits, nutritional status, body weight, and academic performance in children and adolescents.

    Science.gov (United States)

    Rampersaud, Gail C; Pereira, Mark A; Girard, Beverly L; Adams, Judi; Metzl, Jordan D

    2005-05-01

    Breakfast has been labeled the most important meal of the day, but are there data to support this claim? We summarized the results of 47 studies examining the association of breakfast consumption with nutritional adequacy (nine studies), body weight (16 studies), and academic performance (22 studies) in children and adolescents. Breakfast skipping is highly prevalent in the United States and Europe (10% to 30%), depending on age group, population, and definition. Although the quality of breakfast was variable within and between studies, children who reported eating breakfast on a consistent basis tended to have superior nutritional profiles than their breakfast-skipping peers. Breakfast eaters generally consumed more daily calories yet were less likely to be overweight, although not all studies associated breakfast skipping with overweight. Evidence suggests that breakfast consumption may improve cognitive function related to memory, test grades, and school attendance. Breakfast as part of a healthful diet and lifestyle can positively impact children's health and well-being. Parents should be encouraged to provide breakfast for their children or explore the availability of a school breakfast program. We advocate consumption of a healthful breakfast on a daily basis consisting of a variety of foods, especially high-fiber and nutrient-rich whole grains, fruits, and dairy products.

  14. EXPENSES ANALYSIS BASED ON INFORMATION PROVIDED BY THE PROFIT AND LOSS ACCOUNT –COMPANY PERFORMANCE DIAGNOSIS STAGE

    Directory of Open Access Journals (Sweden)

    MARIA DANIELA BONDOC

    2013-10-01

    Full Text Available Expenses represent one component of the binomial that determines a company’s financial performance, the other component being the incomes. Diagnosing performance as part of the performance management has the purpose of providing managers with a feedback on previous actions and it acts as a basis for future decisions. Profit and loss account through its format, offers the possibility to analyze changes at expenses level and the evolution of their structure. This paper aims the analysis of the expenses of a dairy company based on information provided by the profit and loss account followed by the formulation of proposals and conclusions.

  15. Development and validation of a claims-based approach to proxy ECOG performance status across ten tumor groups.

    Science.gov (United States)

    Sheffield, Kristin M; Bowman, Lee; Smith, David M; Li, Li; Hess, Lisa M; Montejano, Leslie B; Willson, Tina M; Davidoff, Amy J

    2018-03-01

    To develop a claims-based prediction model of poor performance status (PS) in commercially insured and Medicare supplemental beneficiaries with cancer. Retrospective analysis was conducted of electronic medical records (EMR) from community oncology practices linked to MarketScan claims. Multivariable logistic regression predicted PS scores from the EMR using claims-based diagnostic and procedure codes. The study included 8442 patients diagnosed with cancer from 2007 to 2015. Overall, 8.1% of patients had poor EMR-based PS. Bootstrapping results from the final model showed sensitivity and specificity of approximately 75% with a predicted probability cutpoint = 0.078, c-statistic = 0.821 and pseudo-R 2 = 0.25. Patients with poor PS can be identified in claims data. This prediction model enables future studies evaluating cancer treatments and outcomes to account for PS.

  16. DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development.

    Science.gov (United States)

    Fontana, Crisciele; Vitolo, Márcia R; Campagnolo, Paula D B; Mattevi, Vanessa S; Genro, Júlia P; Almeida, Silvana

    2015-12-01

    Variants of dopamine system genes such as the DRD4 and the SLC6A3 genes may be involved in food intake regulation because the dopaminergic system influences food reward. We investigated an association of polymorphisms in the DRD4 (exon 3 VNTR) and SLC6A3 (3'UTR VNTR, rs2550948, rs2652511 and rs1048953) genes with food intake and nutritional status in children. This prospective cohort study recruited 359 children at birth. Dietary data and nutritional status were collected at 1 year, 3-4 years, and 7-8 years of age. The polymorphisms were analyzed using polymerase chain reaction based techniques. Food intake and nutritional status were compared among the different SNP genotypes. In the first year of life, DRD4.7R- children showed higher BMI Z-scores (P=.019) than the DRD4.7R+ cohort. At 3-4 years old, DRD4.7R- and SLC6A3.10R/10R children showed a higher intake of palatable foods (P=.024) and a higher waist circumference (P=.017). The rs1048953 SLC6A3 polymorphism was associated with average daily energy intake (P=.003) at 3-4 years and with a waist-to-height ratio of children at 7-8 years (P=.041). Carriers of high dopamine activity alleles of the VNTRs studied in DRD4 and SLC6A3 genes and carriers of T/T genotype of the variant rs1048953 SLC6A3 can present an increased risk for obesity related to overeating because high dopamine activity can increase the perceived incentive value of food reward. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. TROPHIC STATE INDEXES AND PHYTOPLANKTON IN THE TROPHIC STATUS ASSESSMENT OF WATERS OF A SMALL RETENTION RESERVOIR AT AN EARLY STAGE OF OPERATION

    OpenAIRE

    Magdalena Suchora; Agnieszka Szczurowska; Michał Niedźwiecki

    2017-01-01

    This paper will focus on determining the trophic status of the two basins of the Niwa Reservoir - Niwa I and Niwa II (Sawin commune, Lubelskie Province, SE Poland) at the sixth year of operation, by using partial TSI indexes – TSI(SD), TSI(TP), TSI(chl-a), as well as qualitative and quantitative structures of phytoplankton. As a supplementary, index TSI(TOC) was employed [Dunalska 2011]. We show that the phytoplankton abundance, as well as TSI(chl-a) and TSI(TP) were relatively low and typica...

  18. NINTH INTERIM STATUS REPORT: MODEL 9975 PCV O-RING FIXTURE LONG-TERM LEAK PERFORMANCE

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W.

    2014-08-06

    A series of experiments to monitor the aging performance of Viton® GLT O-rings used in the Model 9975 package has been ongoing since 2004 at the Savannah River National Laboratory. One approach has been to periodically evaluate the leak performance of O-rings being aged in mock-up 9975 Primary Containment Vessels (PCVs) at elevated temperatures. Other methods such as compression-stress relaxation (CSR) tests and field surveillance are also on-going to evaluate O-ring behavior. Seventy tests using PCV mock-ups were assembled and heated to temperatures ranging from 200 to 450 ºF. They were leak-tested initially and have been tested periodically to determine if they continue to meet the leak-tightness criterion defined in ANSI standard N14.5-97. Due to material substitution, fourteen additional tests were initiated in 2008 with GLT-S O-rings heated to temperatures ranging from 200 to 400 ºF. High temperature aging continues for 23 GLT O-ring fixtures at 200 – 270 ºF. Room temperature leak test failures have been experienced in all of the GLT O-ring fixtures aging at 350 ºF and higher temperatures, and in 8 fixtures aging at 300 ºF. The earliest 300 °F GLT O-ring fixture failure was observed at 34 months. The remaining GLT O-ring fixtures aging at 300 ºF have been retired from testing following more than 5 years at temperature without failure. No failures have yet been observed in GLT O-ring fixtures aging at 200 ºF for 72 - 96 months, which bounds O-ring temperatures anticipated during storage in K-Area Complex (KAC). Based on expectations that the 200 ºF fixtures will remain leak-tight for a significant period yet to come, 2 additional fixtures began aging in 2011 at 270 ºF, with hopes that they may reach a failure condition before the 200 ºF fixtures, thus providing additional time to failure data. High temperature aging continues for 6 GLT-S O-ring fixtures at 200 – 300 ºF. Room temperature leak test failures have been experienced in all 8 of the

  19. FY2017 status report: Model 9975 O-ring fixture long-term leak performance

    Energy Technology Data Exchange (ETDEWEB)

    Daugherty, W. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-07-27

    A series of experiments to monitor the aging performance of Viton® GLT and GLT-S O-rings used in the Model 9975 shipping package has been ongoing since 2004 at the Savannah River National Laboratory. One approach has been to periodically evaluate the leak performance of O-rings being aged in mock-up 9975 Primary Containment Vessels (PCVs) at elevated temperature. Other methods such as compression-stress relaxation (CSR) tests and field surveillance are also on-going to evaluate O-ring behavior. Seventy tests using PCV mock-ups with GLT O-rings were assembled and heated to temperatures ranging from 200 to 450 ºF. They were leak-tested initially and have been tested periodically to determine if they continue to meet the leak-tightness criterion defined in ANSI standard N14.5-97. Due to material substitution, a smaller test matrix with fourteen additional tests was initiated in 2008 with GLT-S O-rings heated to temperatures ranging from 200 to 400 ºF. Leak test failures have been experienced in all of the GLT O-ring fixtures aging at 350 ºF and higher temperatures, and in 8 fixtures aging at 300 ºF. The 300 °F GLT O-ring fixtures failed after 2.8 to 5.7 years at temperature. The remaining GLT O-ring fixtures aging at 300 ºF were retired from testing following more than 5 years at temperature without failure. No failures have yet been observed in GLT O-ring fixtures aging at 200 ºF for 9 to 10.5 years, or in GLT O-ring fixtures aging at 270 ºF for 5.7 years. These aging temperatures bound O-ring temperatures anticipated during normal storage in K-Area Complex (KAC). Leak test failures have been experienced in all of the GLT-S O-ring fixtures aging at 300 ºF and above. No failures have yet been observed in GLT-S O-ring fixtures aging at 200 and 250 ºF for 6.9 to 7.5 years. Data from the O-ring fixtures are generally consistent with results from compression stress relaxation testing, and provide confidence in the predictive models based on those results

  20. The Effect of Sensory Room Intervention on Perceptual-Cognitive Performance and Psychiatric Status of People with Schizophrenia

    Directory of Open Access Journals (Sweden)

    Ara Shahgholi

    2012-10-01

    Full Text Available Objectives: Individuals with schizophrenia show perceptual-cognitive abnormalities. Besides, depression and anxiety is an integral part of the disease most of the times. People with mental diseases, while under institutional care, experience lack of control and choice in their daily lives. Sensory room is an environment in which individuals can choose, control and explore the stimuli around them. So, they can organize their responses to their environment and restore and develop their skills, interacting through it. Methods: 48 people met the study criteria, who were evaluated with Lowenstein Occupational Therapy Cognitive Assessment, Mini Mental State examination, and Positive and Negative Syndrome Scale. Then they were randomly and equally assigned to intervention and comparison groups. Intervention group received sensory room intervention and comparison group had their traditional therapies. After 32 treatment sessions, 14 participants in intervention group and 7 participants in comparison group were excluded from the study and the tests were repeated for the remaining ones. Results: Findings did not show a significant effect of sensory room intervention on perceptual-cognitive performance and psychiatric status of people with schizophrenia (P>0.05. In reminding domain, however, results indicated maintenance of the skill in intervention group (P>0.05. and exacerbating of that in comparison group (P<0.05. Discussion: No significant change in perceptual-cognitive performance and psychiatric status for individuals with schizophrenia during 3 month period of sensory room intervention was found, except for reminding which did not changed significantly in intervention group, but regressed in comparison group after the intervention period.

  1. For-Profit Hospital Status and Carotid Artery Stent Utilization in US Hospitals Performing Carotid Revascularization.

    Science.gov (United States)

    Chandler, Justin V; George, Benjamin P; Kelly, Adam G; Holloway, Robert G

    2017-11-01

    Carotid artery stenting may be an economically attractive procedure for hospitals and physicians. We sought to identify the association of hospital ownership (nonprofit versus for-profit) on carotid artery stenting (CAS) versus carotid endarterectomy utilization in US hospitals. Using the Nationwide Inpatient Sample admissions for cerebrovascular disease from 2008 to 2011, we identified all private, nonfederal US hospitals performing at least 20 carotid revascularization procedures annually, including carotid artery stenting ( International Classification of Diseases -Ninth Revision 00.63) or carotid endarterectomy ( International Classification of Diseases -Ninth Revision 38.12). We used a multilevel multivariable logistic regression controlling for patient demographics, comorbidities, and hospital characteristics, to assess the effect of hospital ownership on CAS use. Across 723 hospitals (600 nonprofit, 123 for-profit), 66 731 carotid revascularization admissions were identified. Approximately 1 in 5 (n=11 641; 17.4%) revascularizations received CAS. The mean CAS rate among nonprofit hospitals was 17.5 per 100 revascularizations (median, 11.5; interquartile range, 5.2-24.5), and the mean CAS rate among for-profit hospitals was 24.2 per 100 revascularizations (median, 16.0; interquartile range, 6.7-33.3; P hospital characteristics, for-profit hospital designation was associated with greater odds of CAS (adjusted odds ratio, 1.45; 95% confidence interval, 1.07-1.98). For-profit hospital ownership is associated with a higher rate of CAS compared to nonprofit hospitals in those receiving carotid revascularization. Further research is needed to understand the individual- and system-level factors driving this difference. © 2017 American Heart Association, Inc.

  2. The art and ‘science’ of opera: composing, staging & designing new forms of interactive theatrical performance

    OpenAIRE

    Chamberlain, Alan; Kallionpää, Maria; Benford, Steve

    2017-01-01

    New technologies, such as Virtual Reality (VR), Robotics and Artificial Intelligence (AI) are steadily having an impact upon the world of opera. The evolving use of performance-based software such as Ableton Live and Max/MSP has created new and exciting compositional techniques that intertwine theatrical and musical performance. This poster presents some initial work on the development of an opera using such technologies that is being composed by Kallionpää and Chamberlain.

  3. Performance analysis of the single-stage absorption heat transformer using a new working pair composed of ionic liquid and water

    International Nuclear Information System (INIS)

    Zhang Xiaodong; Hu Dapeng

    2012-01-01

    The performance simulation of a single-stage absorption heat transformer using a new working pair composed of ionic liquids, 1-ethyl-3-methylimidazolium dimethylphosphate, and water (H 2 O + [EMIM][DMP]), was performed based on the thermodynamic properties of the new working pair and on the mass and energy balance for each component of the system. In order to evaluate the new working pair, the simulation results were compared with those of aqueous solution of lithium bromide (H 2 O + LiBr), Trifluoroethanol (TFE) + tetraethylenglycol dimethylether (E181). The results indicate that when generation, evaporation, condensing and absorption temperatures are 90 °C, 90 °C, 35 °C and 130 °C, the coefficients of performance of the single-stage absorption heat transformer using H 2 O + LiBr, H 2 O + [EMIM][DMP] and TFE + E181 as working pairs will reach 0.494, 0.481 and 0.458 respectively. And the corresponding exergy efficiency will reach 0.64, 0.62 and 0.59, respectively. Meanwhile the available heat outputs for per unit mass of refrigerant are 2466 kJ/kg, 2344 kJ/kg and 311 kJ/kg, respectively. The above excellent cycle performance together with the advantages of negligible vapor pressure, no crystallization and more weak corrosion tendency to iron-steel materials may make the new working pair better suited for the industrial absorption heat transformer. - Highlights: ► The cycle performance of the single-stage absorption heat transformer was simulated. ► Water and 1-ethyl-3-methylimidazolium dimethylphosphate was used as new working pair. ► Water and 1-ethyl-3-methylimidazolium dimethylphosphate are entirely miscible. ► The COP and exergy efficiency for this new working pairs were 0.481 and 0.62. ► The new working pairs has potential application to absorption heat transformer.

  4. Prognostic impact of programmed death-ligand 1 expression in correlation with human leukocyte antigen class I expression status in stage I adenocarcinoma of the lung.

    Science.gov (United States)

    Hirai, Ayako; Yoneda, Kazue; Shimajiri, Shohei; Kuroda, Koji; Hanagiri, Takeshi; Fujino, Yoshihisa; Tanaka, Fumihiro

    2018-01-01

    The study objective was to investigate the prognostic impact of programmed death-ligand 1 expression in correlation with human leukocyte antigen class I expression on tumor cells in early-stage adenocarcinoma of the lung, because both programmed death-ligand 1 and human leukocyte antigen class I molecules play important roles in cancer immunity. Ninety-four patients with completely resected pathologic stage I lung adenocarcinoma were retrospectively reviewed. Programmed death-ligand 1 expression on tumor cells was evaluated with immunohistochemistry in correlation with several clinicopathologic and molecular features, including human leukocyte antigen class I expression on tumor cells. Fifteen patients (16.0%) had tumor with positive programmed death-ligand 1 expression (percentage of tumor cells expressing programmed death-ligand 1, ≥5%), and the incidence was significantly higher in poorly differentiated tumors. There was no significant correlation between human leukocyte antigen class I expression and programmed death-ligand 1 expression. Programmed death-ligand 1 positivity was a significant factor to predict a poor survival (5-year survival, 66.7% vs 85.9%; P = .049), which was enhanced in tumors with normal human leukocyte antigen class I expression (P = .029) but was not evident in tumors with reduced human leukocyte antigen class I expression (P = .552). The prognostic impact of programmed death-ligand 1 expression on tumor cells in early-stage lung adenocarcinoma may be distinct according to concurrent human leukocyte antigen class I expression. Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

  5. Artificial insemination of cattle in Sri Lanka: Status, performance and problems

    International Nuclear Information System (INIS)

    Abeygunawardena, H.; Alexander, P.A.B.D.; Abeygunawardena, I.S.

    2001-01-01

    Artificial insemination (AI) has been accepted as the primary breeding tool in genetic upgrading programmes of cattle in Sri Lanka. Three studies were conducted, to determine the coverage and performance of AI at national, provincial and district levels (Study 1), the success rate and factors affecting success rate of AI in wet zone mid-country smallholder farms (Study 2) and in wet zone up-country large multiplier farms (Study 3). The objective was to design, implement remedial measures and/or determine future studies necessary to improve the efficiency of AI services. Study 1 revealed that at national level the AI service reached less than 15% of the breedable cattle and accounted for less than 6% of estimated annual calvings. The coverage reached above 50% of the breedable cattle only in the wet zone while in the intermediate and dry zone areas it was negligible. Study 2 revealed that the mean calving to first service interval (CFSI) in cattle of the wet zone mid-country small holdings was 183 ± 87.1 days (n=211) and the calving to conception interval (CCI) was 194 ± 93.9 days (n=143). The first service conception rate (FSCR) was 45% and the overall conception rate (OCR) was 50.2%, with an average of 1.99 services per conception (S/C). Study 3 showed that the mean CFSI and CCI in wet zone upcountry multiplier farmers were 111.2 ± 74.2 days (n=133) and 156 ± 92.7 days (n=170) respectively. The average FSCR and OCR were 50.4% and 53.6% respectively and the average S/C was 1.9. Study 1 showed that the AI coverage of the island is very low and the proportion of calvings from AI is too low to have a significant impact on genetic composition of the national cow population. Studies 2 and 3 showed that the success rate of the AI service in the more favourable and extensively covered wet zone areas was also low. These studies revealed that factors associated with the chain of events from farmer, cow, semen to the technician contributed to poor fertility. (author)

  6. The SEIS Experiment for the InSight mission: status and performance expectations

    Science.gov (United States)

    Mimoun, David; Lognonne, Philippe; Banerdt, W. Bruce; Laudet, Philippe; De Raucourt, Sébastien; IJpelaan, Frans; Kerjean, Laurent; Perez, Rene; Pont, Gabriel; Sylvestre-Baron, Annick; verdier, Nicolas; Denise, Robert; Feldman, Jason; Hurst, Ken; Klein, Kerry; Giardini, Domenico; Zweifel, Peter; Pike, W. Tom; Calcutt, Simon; Bramanti, Christina

    2015-04-01

    discussion will be presented, on how to understand the seismometer performance figure in a changing environment, and how to secure the mission science goals in the challenging environment of the Mars surface.

  7. Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Carolina de Medeiros Rimkus

    2013-01-01

    Full Text Available OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS with diffusion tensor imaging and to investigate the correlation of this damage with disability. The diffusion tensor imaging parameters of fractional anisotropy and mean diffusivity provide information about the integrity of cell membranes, offering two more specific indices, namely the axial and radial diffusivities, which are useful for discriminating axon loss from demyelination. METHOD: Brain magnetic resonance imaging exams of 30 relapsing-remitting multiple sclerosis patients and 30 age- and sex-matched healthy controls were acquired in a 3T scanner. The axial diffusivities, radial diffusivities, fractional anisotropy, and mean diffusivity of five segments of the corpus callosum, correlated to the Expanded Disability Status Scale score, were obtained. RESULTS: All corpus callosum segments showed increased radial diffusivities and mean diffusivity, as well as decreased fractional anisotropy, in the relapsing-remitting multiple sclerosis group. The axial diffusivity was increased in the posterior midbody and splenium. The Expanded Disability Status Scale scores correlated more strongly with axial diffusivities and mean diffusivity, with an isolated correlation with radial diffusivities in the posterior midbody of the corpus callosum. There was no significant correlation with lesion loads. CONCLUSION: Neurological dysfunction in relapsing-remitting multiple sclerosis can be influenced by commissural disconnection, and the diffusion indices of diffusion tensor imaging are potential biomarkers of disability that can be assessed during follow-up.

  8. One stage functional end-to-end stapled intestinal anastomosis and resection performed by nonexpert surgeons for the treatment of small intestinal obstruction in 30 dogs.

    Science.gov (United States)

    Jardel, Nicolas; Hidalgo, Antoine; Leperlier, Dimitri; Manassero, Mathieu; Gomes, Aymeric; Bedu, Anne Sophie; Moissonnier, Pierre; Fayolle, Pascal; Begon, Dominique; Riquois, Elisabeth; Viateau, Véronique

    2011-02-01

    To describe stapled 1-stage functional end-to-end intestinal anastomosis for treatment of small intestinal obstruction in dogs and evaluate outcome when the technique is performed by nonexpert surgeons after limited training in the technique. Case series. Dogs (n=30) with intestinal lesions requiring an enterectomy. Stapled 1-stage functional end-to-end anastomosis and resection using a GIA-60 and a TA-55 stapling devices were performed under supervision of senior residents and faculty surgeons by junior surgeons previously trained in the technique on pigs. Procedure duration and technical problems were recorded. Short-term results were collected during hospitalization and at suture removal. Long-term outcome was established by clinical and ultrasonographic examinations at least 2 months after surgery and from written questionnaires, completed by owners. Mean±SD procedure duration was 15±12 minutes. Postoperative recovery was uneventful in 25 dogs. One dog had anastomotic leakage, 1 had a localized abscess at the transverse staple line, and 3 dogs developed an incisional abdominal wall abscess. No long-term complications occurred (follow-up, 2-32 months). Stapled 1-stage functional end-to-end anastomosis and resection is a fast and safe procedure in the hand of nonexpert but trained surgeons. © Copyright 2011 by The American College of Veterinary Surgeons.

  9. Biomonitoring of physiological status and cognitive performance of underway submariners undergoing a novel watch-standing schedule

    Science.gov (United States)

    Duplessis, C. A.; Cullum, M. E.; Crepeau, L. J.

    2005-05-01

    Submarine watch-standers adhere to a 6 hour-on, 12 hour-off (6/12) watch-standing schedule, yoking them to an 18-hr day, engendering circadian desynchronization and chronic sleep deprivation. Moreover, the chronic social crowding, shift work, and confinement of submarine life provide additional stressors known to correlate with elevated secretory immunoglobulin A (sIgA) and cortisol levels, reduced performance, immunologic dysfunction, malignancies, infections, gastrointestinal illness, coronary disease, anxiety, and depression. We evaluated an alternative, compressed, fixed work schedule designed to enhance circadian rhythm entrainment, sleep hygiene, performance, and health on 10 underway submariners, who followed the alternative and 6/12 schedules for approximately 2 weeks each. We measured subjects" sleep, cognitive performance, and salivary biomarker levels. Pilot analysis of the salivary data on one subject utilizing ELISA suggests elevated biomarker levels of stress. Average PM cortisol levels were 0.2 μg/L (normal range: nondetectable - 0.15 μg/L), and mean sIgA levels were 562 μg/ml (normal range: 100-500 μg/ml). Future research exploiting real-time salivary bioassays, via fluorescent polarimetry technology, identified by the Office of Naval Research (ONR) as a future Naval requirement, allows researchers to address correlations between stress-induced elaboration of salivary biomarkers with physiological and performance decrements, thereby fostering insight into the underway submariner"s psychoimmunological status. This may help identify strategies that enhance resilience to stressors. Specifically, empirically-based modeling can identify optimal watch-standing schedules and stress-mitigating procedures -- within the operational constraints of the submarine milieu and the mission --that foster improved circadian entrainment and reduced stress reactivity, enhancing physiological health, operational performance, safety, and job satisfaction.

  10. A pilot randomized trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses.

    Science.gov (United States)

    Hidderley, Margaret; Holt, Martin

    2004-03-01

    Autogenic training (AT) is a type of meditation usually used for reducing stress. This pilot study describes how AT was used on a group of early stage cancer patients and the observed effect on stress-related behaviours and immune system responses. This was a randomized trial with 31 early stage breast cancer women, having received a lumpectomy and adjuvant radiotherapy. The women were randomized into two groups. Group 1 received a home visit only. Group 2 received a home visit and 2 months' weekly Autogenic training. At the beginning and end of the 2 monthly periods, the Hospital Anxiety and Depression Scale (HADS) and T and B cell markers were measured to give an indication of changes in immune system responses and measurement of anxiety and depression. At the end of the study, HADS scores and T and B cell markers remained similar in the women who did not receive AT. The women receiving AT showed a strong statistical difference for an improvement in their HADS scores and those women observed in a meditative state as opposed to a relaxed state were found to have an increase in their immune responses. This study suggests AT as a powerful self-help therapy.

  11. Effect of powdered activated carbon (PAC) on MBR performance and effluent trihalomethane formation: At the initial stage of PAC addition.

    Science.gov (United States)

    Gao, Yue; Ma, Defang; Yue, Qinyan; Gao, Baoyu; Huang, Xia

    2016-09-01

    In this study, the MBR was used to treat municipal wastewater for reuse. Effects of powdered activated carbon (PAC) addition on MBR system in terms of effluent water quality, trihalomethane (THM) formation and membrane organic fouling tendency of MBR sludge supernatant at the initial stage of PAC addition were investigated. Effects of chlorine dose and contact time on THM formation and speciation were also studied. PAC addition enhanced the removal of organic matters, especially aromatic components, which improved the UV254 removal rate from 34% to 83%. PAC addition greatly reduced the membrane organic fouling tendency of MBR sludge supernatant. PAC addition reduced the MBR effluent trihalomethane formation potential (THMFP) from 351.29 to 241.95μg/L, while increased THM formation reactivity by 42%. PAC addition enhanced the formation of higher toxic bromine-containing THMs. High chlorine dose and contact time resulted in higher THM formation but lower proportion of bromine-containing THMs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Performance Evaluation of Low/Zero Voltage Ride-Through Operations for Single-Stage Single-Phase Photovoltaic Inverters

    DEFF Research Database (Denmark)

    Zhang, Zhen; Yang, Yongheng; Blaabjerg, Frede

    2017-01-01

    With the fast development of distributed power generations, stability and security have attracted extensive attention in the recent years. As a representative of clean energies, Photovoltaic (PV) systems have been installed extensively worldwide. This drives grid-connected requirements to be cont......With the fast development of distributed power generations, stability and security have attracted extensive attention in the recent years. As a representative of clean energies, Photovoltaic (PV) systems have been installed extensively worldwide. This drives grid-connected requirements......-connected single-stage single-phase PV systems in the case of Low/Zero Voltage Ride-Through (LVRT/ZVRT) operation. A comparative analysis of the two LVRT/ZVRT control methods for PV systems is presented. Simulation results are presented, which verifies that the LVRT/ZVRT methods can help the PV systems...... to temporarily ride-through the grid low-/zero-voltage faults. The power phase-angle control method has a better dynamic response....

  13. Comparison of mediastinal lymph node status and relapse pattern in clinical stage IIIA non‐small cell lung cancer patients treated with neoadjuvant chemotherapy versus upfront surgery: A single center experience

    Science.gov (United States)

    Savic, Milan; Ercegovac, Maja; Stojsic, Jelena; Bascarevic, Slavisa; Moskovljevic, Dejan; Kostic, Marko; Vesovic, Radomir; Popevic, Spasoje; Laban, Marija; Markovic, Jelena; Jovanovic, Dragana

    2017-01-01

    Background In spite of the progress made in neoadjuvant therapy for operable non small‐cell lung cancer (NSCLC), many issues remain unsolved, especially in locally advanced stage IIIA. Methods Retrospective data of 163 patients diagnosed with stage IIIA NSCLC after surgery was analyzed. The patients were divided into two groups: a preoperative chemotherapy group including 59 patients who received platinum‐etoposide doublet treatment before surgery, and an upfront surgery group including 104 patients for whom surgical resection was the first treatment step. Adjuvant chemotherapy or/and radiotherapy was administered to 139 patients (85.3%), while 24 patients (14.7%) were followed‐up only. Results The rate of N2 disease was significantly higher in the upfront surgery group (P  0.05). Conclusion There was significant difference in preoperative chemotherapy group regarding relapse rate and treatment outcomes related to the lymph node status comparing to the upfront surgery group. Neoadjuvant/adjuvant chemo‐therapy is a part of treatment for patients with stage IIIA NSCLC, but further investigation is required to determine optimal treatment. PMID:28671758

  14. Survival outcomes in patients with cervical cancer after inclusion of PET/CT in staging procedures

    DEFF Research Database (Denmark)

    Hansen, Henrik Villibald; Loft, Annika; Berthelsen, Anne Kiil

    2015-01-01

    , performance status, BMI, and histopathology. CONCLUSION: Inclusion of PET/CT in the preradiotherapy diagnostic protocol may lead to nodal stage migration not reflected in the FIGO stage. It was found to be a significant covariate, and could lead to selection bias that needs to be taken into account when...... designing and reporting on clinical trials....

  15. Effects of a saturated layer and recirculation on nitrogen treatment performances of a single stage Vertical Flow Constructed Wetland (VFCW).

    Science.gov (United States)

    Prigent, S; Paing, J; Andres, Y; Chazarenc, F

    2013-01-01

    Upgrades to enhance nitrogen removal were tested in a 2 year old pilot vertical flow constructed wetland in spring and summer periods. The effects of a saturated layer and of recirculation were tested in particular. Two pilots (L = 2 m, W = 1.25 m, H = 1.2 m), filled with expanded schist (Mayennite(®)), were designed with hydraulic saturated layers of 20 and 40 cm at the bottom. Each pilot was fed with raw domestic wastewater under field conditions according to a hydraulic load of 15-38 cm d(-1) (i.e. 158-401 g COD (chemical oxygen demand) m(-2) d(-1)) and to recirculation rates ranging from 0% up to 150%. The initial load during the first 2 years of operation resulted in an incomplete mineralized accumulated sludge leading to total suspended solids (TSS), COD and biochemical oxygen demand (BOD5) release. A 40 cm hydraulic saturated layer enabled an increase of 5-10% total nitrogen (TN) removal compared to a 20 cm saturated layer. Recirculation allowed the dilution of raw wastewater and enhanced nitrification in a single stage. A design of 1.8 m² pe(-1) (48 cm d(-1), 191 g COD m(-2) d(-1)) with a 40 cm saturated layer and 100% recirculation enabled the French standard D4 (35 mg TSS L(-1), 125 mg COD L(-1), 25 mg BOD5 L(-1)), nitrogen concentrations below 20 mg TKN (total Kjeldahl nitrogen) L(-1) and 50 mg TN L(-1), to be met.

  16. Nutrition and hydration status improve with exercise training using stationary cycling during hemodialysis (HD) in patients with end-stage renal disease (ESRD).

    Science.gov (United States)

    Załuska, Alicja; Załuska, Wojciech T; Bednarek-Skublewska, Anna; Ksiazek, Andrzej

    2002-01-01

    Patients with end-stage renal disease (ESRD) undergoing hemodialysis and peritoneal dialysis are functionally limited as a consequence of their physical, emotional, and social problems. Exercise intolerance is a major problem in chronic renal failure. Stationary cycle training during hemodialysis is recommended as safe, effective, and practical in ESRD patients treated on hemodialysis. The aim of the present study was to evaluate the effect of cycling exercises in 10 HD patients during 6-month period (including each of dialysis sessions) on nutrition, dialysis adequacy, and fluid parameters as measured by biochemical, and bioimpedance parameters. A significant increase in serum albumin concentration, Kt/V, and nPCR, and decrease in serum CRP have been observed after 6 months of regular stationary cycling during hemodialysis. Relative changes (pre-post HD) in extracellular water compartment and ECW/TBW ratio have significantly increased after 6 months of observation period.

  17. The age-gender-status profile of high performing athletes in the UK taking nutritional supplements: Lessons for the future

    Directory of Open Access Journals (Sweden)

    Naughton Declan P

    2008-01-01

    Full Text Available Abstract Background Owing to the mechanics of anti-doping regulation via the World Anti-Doping Agency's Prohibited List, nutritional supplement use received little attention in comparison to the prevalence of doping. The aims of this study were to investigate supplement use, identify groups of athletes with high levels of supplement use and the prevalence of concomitant use of supplements. Methods Survey data from 847 high-performing athletes in the UK were analysed using descriptive statistics. The survey, conducted by UK Sport, consisted of questions regarding knowledge of the prohibited substances, testing procedure, nutritional supplement use and perceptions of the doping problem. The proportion of supplement users and the relative use of each supplement were compared by age, gender and professional status. Results Among 874 high-performing athletes in the UK sample, 58.8% of them reported the use of at least one nutritional supplement. Among supplement users, 82.6% used more than one and 11.5% reported use of more than five nutritional supplements. Of the 9 supplements listed, multivitamins (72.6% and vitamin C (70.7% were used most, followed by creatine (36.1%, whey protein (31.7%, echinacea (30.9%, iron (29.9% and caffeine (23.7%. Less than 11% reported the use of magnesium or ginseng. Creatine use was typically associated with males regardless of status and across all ages, whereas iron was characteristically used by females. A 'typical' supplement user is male, between 24 and 29 years of age, involved in professional sport and using a combination of supplements. Male professional players between age 30 and 34 years, and female non-professional athletes between 24 and 29 years of age also represented a considerable proportion of supplement users. Athletes older than 40 years of age were practically non-users. Concomitant use of supplements is characteristic of male users more than females. Conclusion As supplement use has been previously

  18. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  19. Differences in mathematics and science performance by economic status, gender, and ethnicity/race: A multiyear Texas statewide study

    Science.gov (United States)

    Anderson, Pamela Bennett

    Purpose. The purpose of the first study was to ascertain the extent to which differences were present in the STAAR Mathematics and Science test scores by Grade 5 and Grade 8 student economic status. The purpose of the second study was to examine differences in Grade 5 STAAR Mathematics and Science test performance by gender and by ethnicity/race (i.e., Asian, Black, Hispanic, and White). Finally, with respect to the third study in this journal-ready dissertation, the purpose was to investigate the STAAR Mathematics and Science test scores of Grade 8 students by gender and by ethnicity/race (i.e., Asian, Black, Hispanic, and White). Method. For this journal-ready dissertation, a non-experimental, causal-comparative research design (Creswell, 2009) was used in all three studies. Grade 5 and Grade 8 STAAR Mathematics and Science test data were analyzed for the 2011-2012 through the 2014-2015 school years. The dependent variables were the STAAR Mathematics and Science test scores for Grade 5 and Grade 8. The independent variables analyzed in these studies were student economic status, gender, and ethnicity/race. Findings. Regarding the first study, statistically significant differences were present in Grade 5 and Grade 8 STAAR Mathematics and Science test scores by student economic status for each year. Moderate effect sizes (Cohen's d) were present for each year of the study for the Grade 5 STAAR Mathematics and Science exams, Grade 8 Science exams, and the 2014-2015 Grade 8 STAAR Mathematics exam. However, a small effect size was present for the 2011-2012 through 2013-2014 Grade 8 STAAR Mathematics exam. Regarding the second and third study, statistically significant differences were revealed for Grade 5 and Grade 8 STAAR Mathematics and Science test scores based on gender, with trivial effect sizes. Furthermore, statistically significant differences were present in these test scores by ethnicity/race, with moderate effects for each year of the study. With regard to

  20. Dietary inclusion level and time effects of taurine on broiler performance, meat quality, oxidative status and muscle taurine content.

    Science.gov (United States)

    Huang, C X; Wang, B; Min, Z; Yuan, J

    2014-01-01

    Two experiments were conducted to investigate the effect of taurine on growth performance, meat quality, oxidative status and muscle taurine content in broilers. In Experiment 1, 50 one-day-old male Cobb chicks were given a diet supplemented with 0, 0.125, 0.50, 2.00 or 8.00 g/kg taurine from 1 to 42 d of age. In Experiment 2, 80 22-d-old male Cobb chicks were given a diet supplemented with 4.00 g/kg taurine for 0, 1, 2 or 3 weeks. Taurine contents of thigh and breast muscle increased linearly with increasing dietary taurine. Taurine supplementation for 1, 2 and 3 weeks significantly increased the taurine content of breast muscle. The taurine contents of liver and thigh meat were significantly increased by taurine supplementation for 3 weeks. The taurine contents of thigh and breast meat from broilers given a diet supplemented with 4 g/kg taurine for 3 weeks increased to 1.89 times the concentrations of the control group. There were no detrimental effects on growth performance, breast or thigh muscle yield, pH value or drip-water loss, and taurine supplementation did not affect the serum carbonyl content. Serum malondialdehyde concentration was significantly decreased by taurine supplementation for 1, 2 or 3 weeks.

  1. Sedentary behavior during school-time: Sociodemographic, weight status, physical education class, and school performance correlates in Brazilian schoolchildren.

    Science.gov (United States)

    da Costa, Bruno G G; da Silva, Kelly S; George, Amanda M; de Assis, Maria Alice A

    2017-01-01

    To investigate whether sedentary behavior during school-time is associated with gender, age, mother's education, having physical education classes, weight status, and academic performance. Cross-sectional study. A sample of 571 children (7-12 years old) from five elementary schools in Florianopolis, South Brazil had their height and weight measured, and wore accelerometers during class time. Teachers completed a form to evaluate children's reading and writing skills. Parents provided sociodemographic and educational information. Data was analyzed using multilevel linear regression analyses. Children spent an average of 132min in sedentary behavior during school-time (64% of total school-time). Girls (137.5min), obese children (138.1min), older children (144.2min), and those who did not have physical education classes (140.2min) spent more time engaged in sedentary activities than their peers. Academic performance and mother's education were not associated with sedentary behaviors. Children spent most of their school-time in sedentary activities, with girls, older students, and obese students being even more sedentary than their peers. Physical education classes were a protective factor against excessive sedentary behavior in school. Interventions for reducing sedentary behavior during school-time could employ additional strategies to benefit the at risk groups. In addition, encouraging student's participation in physical education classes could minimize the time spent in sedentary behavior during school hours. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  2. Step-Up Partial Power DC-DC Converters for Two-Stage PV Systems with Interleaved Current Performance

    Directory of Open Access Journals (Sweden)

    Jaime Wladimir Zapata

    2018-02-01

    Full Text Available This work presents a partial power converter allowing us to obtain, with a single DC-DC converter, the same feature as the classical interleaved operation of two converters. More precisely, the proposed topology performs similarly as the input-parallel output-series (IPOS configuration reducing the current ripple at the input of the system and dividing the individual converters power rating, compared to a single converter. The proposed topology consists of a partial DC-DC converter processing only a fraction of the total power, thus allowing high efficiency. Experimental results are provided to validate the proposed converter topology with a Flyback-based 100 W test bench with a transformer turns ratio n 1 = n 2 . Experimental results show high performances reducing the input current ripple around 30 % , further increasing the conversion efficiency.

  3. Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Young Eun Chon

    Full Text Available Transient elastography (TE, a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC. However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB.Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC and diagnostic accuracy values of each study.A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2, severe fibrosis (F3, and cirrhosis (F4 were 0.859 (95% confidence interval [CI], 0.857-0.860, 0.887 (95% CI, 0.886-0.887, and 0.929 (95% CI, 0.928-0.929, respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8 kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7 kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5 kPa, with a sensitivity of 84.6% and specificity of 81.5%.TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.

  4. A simulation study on performance evaluation of single-stage LiBr–H2O vapor absorption heat pump for chip cooling

    Directory of Open Access Journals (Sweden)

    Manu S.

    2016-12-01

    Full Text Available The growth of Lithium Bromide–Water (LiBr–H2O absorption based heat pump is encouraged for the necessity of extracting high heat from the electronic chips. This paper presents a simulation study of single-stage LiBr–H2O vapor absorption heat pump for chip cooling. In this study, a detailed thermodynamic analysis of the single-stage LiBr–H2O vapor absorption heat pump for chip cooling in the nonexistence of solution heat exchanger was performed and a user-friendly graphical user interface (GUI package including visual components was developed by using MATlab (2008b. The influence of chip temperature on COP (Coefficient of Performance, flow rates and conductance was examined by using the developed package. The model is validated by using the values available in the literature and indicates that there is a greater reduction in the absorber load. The influence of chip temperature on the performance and thermal loads of individual components was studied and it was concluded that, COP increases from 0.7145 to 0.8421 with an increase in chip temperature.

  5. Effects of preventive versus "on-demand" nutritional support on paid labour productivity, physical exercise and performance status during PEG-interferon-containing treatment for hepatitis C.

    Science.gov (United States)

    Huisman, Ellen J; van Meer, Suzanne; van Hoek, Bart; van Soest, Hanneke; van Nieuwkerk, Karin M J; Arends, Joop E; Siersema, Peter D; van Erpecum, Karel J

    2016-04-01

    Deterioration of nutritional status during PEG-interferon containing therapy for chronic hepatitis C can be ameliorated by preventive nutritional support. We aimed to explore whether such support also affects paid labour productivity, physical exercise and performance status. In this prospective randomized controlled trial (J Hepatol 2012;57:1069-75), 53 patients with chronic hepatitis C had been allocated to "on demand" support (n=26: nutritional intervention if weight loss>5%) or preventive support (n=27: regular dietary advice plus energy- and protein-rich evening snack) during PEG-interferon-containing therapy. Paid labour productivity, physical exercise and performance status were evaluated at baseline, after 24 and (if applicable) after 48 weeks of treatment. At baseline, 46% of patients performed paid labour and 62% performed some kind of physical exercise. Furthermore, most patients were able to carry out normal activity with only minor symptoms of disease (mean Karnofsky performance score: 94). Decreases of paid labour productivity (-21% vs. -70%, P=0.003), physical exercise activity (-43% vs. -87%, P=0.005) and Karnofsky performance scores (-12% vs. -24%, Pnutritional support were even more pronounced after 48 weeks. Preventive nutritional support markedly ameliorates decreases of paid labour productivity, physical exercise and performance status during PEG-interferon-containing treatment for chronic hepatitis C. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  6. Stage design

    International Nuclear Information System (INIS)

    Shacter, J.

    1975-01-01

    A method is described of cycling gases through a plurality of diffusion stages comprising the steps of admitting the diffused gases from a first diffusion stage into an axial compressor, simultaneously admitting the undiffused gases from a second diffusion stage into an intermediate pressure zone of said compressor corresponding in pressure to the pressure of said undiffused gases, and then admitting the resulting compressed mixture of diffused and undiffused gases into a third diffusion stage

  7. Effect of hydraulic retention time on up-flow anaerobic stage reactor performance at constant loading in the presence of antibiotic tylosin

    Directory of Open Access Journals (Sweden)

    S. Chelliapan

    2011-03-01

    Full Text Available The present investigation was aimed at determining the impact of the macrolide antibiotic Tylosin in reduced HRT at constant organic loading rate (OLR by varying feed substrate concentration in an up-flow anaerobic stage reactor (UASR. The antibiotic concentration was maintained at 200 mg.L-1, at constant OLR of 1.88 kg COD.m-3.d-1, by varying feed substrate concentration to the UASR and the HRT was decreased gradually from 4 to 1 d. Throughout the operation period, brewery wastewater was used as simple feed substrate to elevate the concentration of easily biodegradable carbon in comparison with the concentrations of more recalcitrant Tylosin substrate. The reactor alkalinity was controlled in all the stages of UASR by adding 1000 - 2000 mg.L-1 CaCO3. Results showed the total COD removal efficiency at 4 d HRT was around 92%, after which point there was a slight decrease at 3 and 2 d HRT (average 82%, and this was reduced further (average 77% at a HRT of 1 d. The UASR showed stable operation with effluent volatile fatty acid (VFA less than 300 mg.L-1 throughout the experimental period (HRT 4 - 1 d. Moreover, the average methane yield (CH4.kg CODr-1 showed a relatively constant profile and was largely unaffected by HRT in all the stages of UASR. These results show that bacteria were readily adapted to wastewater containing Tylosin at lower HRTs and did not affect the reactor performance substantially.

  8. The Influence of the Seed Pulse Shape on the Output Performance of the BESSY Multi-stage HGHG-FEL

    CERN Document Server

    Meseck, Atoosa; Kuske, Bettina

    2004-01-01

    The BESSY soft X-ray FEL is planned as a High Gain Harmonic Generation (HGHG) FEL multi-user facility covering the VUV to soft X-ray spectral range. In the HGHG scheme, the properties of the radiation output are dominated by the characteristics of the laser seed. In this connection, the influence of the laser pulse shape on the output, in particular on the output spectrum is of interest. Simulation studies for the BESSY-HGHG-FELs are presented and the output performance for different shapes of the laser pulse is discussed.

  9. Bank Mergers Performance and the Determinants of Singaporean Banks’ Efficiency: An Application of Two-Stage Banking Models

    Directory of Open Access Journals (Sweden)

    Fadzlan Sufian

    2007-01-01

    Full Text Available An event study window analysis of Data Envelopment Analysis (DEA is employed in this study to investigate the effect of mergers and acquisitions on Singaporean domestic banking groups’ efficiency. The results suggest that the mergers have resulted in a higher post-merger mean overall efficiency of Singaporean banking groups. However, from the scale efficiency perspective, our findings do not support further consolidation in the Singaporean banking sector. We find mixed evidence of the efficiency characteristics of the acquirers and targets banks. Hence, the findings do not fully support the hypothesis that a more (less efficient bank becomes the acquirer (target. In most cases, our results further confirm the hypothesis that the acquiring bank’s mean overall efficiency improves (deteriorates post-merger resulted from the merger with a more (less efficient bank. Tobit regression model is employed to determine factors affecting bank performance, and the results suggest that bank profitability has a significantly positive impact on bank efficiency, whereas poor loan quality has a significantly negative influence on bank performance.

  10. Physical fitness as an indicator of health status and its relationship to academic performance during the prepubertal period.

    Science.gov (United States)

    Fonseca Del Pozo, Francisco Javier; Alonso, Joaquín Valle; Álvarez, Manuel Vaquero; Orr, Siobhan; Cantarero, Francisco Jesús Llorente

    2017-01-01

    Background: Physical activity (PA) is considered one of the most important determinants of the health status in children, and predictor of morbidity/mortality in adults. The aim is to examine the relationship between physical fitness (PF), PA, obesity and academic performance (AP) in primary school children. Methods: Cross-sectional studies including 91 primary school students, aged 9 to 12 years, from the province of Córdoba. Data was collected from April to June 2014. We measured PF using part of the EUROFIT fitness testing battery. The level of PA was measured as low or high PF and the level of obesity was measured using body mass index, waist circumference, percentage of fat mass, lean body mass, percentage of lean mass and basal metabolism. AP by scores on the second quarter was based on the total average of scores of basic subjects and other subjects, including physical education. Cognitive performance was assessed by the Spanish overall and factorial intelligence test. Results: The results of AP were positively related to levels of PF. Students who achieve better PF score better in Maths, (P=0.019), Natural Sciences (P=0.024), Religion (P=0.018) and Physical Education (P<0.001). A direct association between maximal aerobic capacity with Mathematics (r=0.325, P=0.02), AP (r=0.349, P=0.001) and cognitive performance (CP)(r=0.312, P=0.003) was observed. There was also a direct association of better jump tests with higher AP (r=0.328, P=0.002). Conclusion: The AP is associated with higher levels of fitness. Therefore, the education system should consider implementing curriculum strategies favouring the improvement of the PF, and therefore the health and AP of students.

  11. Physical fitness as an indicator of health status and its relationship to academic performance during the prepubertal period

    Directory of Open Access Journals (Sweden)

    Francisco Javier Fonseca del Pozo

    2017-09-01

    Full Text Available Background: Physical activity (PA is considered one of the most important determinants of the health status in children, and predictor of morbidity/mortality in adults. The aim is to examine the relationship between physical fitness (PF, PA, obesity and academic performance (AP in primary school children Methods: Cross-sectional studies including 91 primary school students, aged 9 to 12 years, from the province of Córdoba. Data was collected from April to June 2014. We measured PF using part of the EUROFIT fitness testing battery. The level of PA was measured as low or high PF and the level of obesity was measured using body mass index, waist circumference, percentage offal mass, lean body mass, percentage of lean mass and basal metabolism. AP by scores on the second quarter was based on the total average of scores of basic subjects and other subjects, including physical education. Cognitive performance was assessed by the Spanish overall and factorial intelligence test.Results: The results of AP were positively related to levels of PF. Students who achieve better PF score better in Maths, (P=0.019, Natural Sciences (P=0.024, Religion (P=0.018 and Physical Education (P<0.001. A direct association between maximal aerobic capacity with Mathematics (r=0.325, P=0.02, AP (r=0.349, P=0.001 and cognitive performance (CP(r=0.312, P=0.003 was observed. There was also a direct association of better jump tests with higher AP (r=0.328, P=0.002.Conclusion: The AP is associated with higher levels of fitness. Therefore, the education system should consider implementing curriculum strategies favouring the improvement of the PF, and therefore the health and AP of students.

  12. Associations Among Food Insecurity, Academic Performance, and Weight Status in Primary Schoolchildren in Tehran, Iran: A Cross-sectional Study.

    Science.gov (United States)

    Esfandiari, Saeed; Omidvar, Nasrin; Eini-Zinab, Hassan; Doustmohammadian, Aazam; Amirhamidi, Zeynab

    2018-02-01

    To examine the associations among household food insecurity (FI), academic performance, and weight status in urban primary schoolchildren. Cross-sectional study. Primary schools in Tehran, Iran. A total of 803 students (419 boys and 384 girls), aged 10-12 years, were recruited from 43 primary schools. Levels of FI were measured using a locally validated, 18-item household food security survey module. Academic performance was assessed by 152 teachers through a specifically designed, 20-scale questionnaire. Standard anthropometric measurements were also taken. Linear and multinomial regressions were conducted. At the household level, FI was associated with poorer grades in all subjects studied (except for social science in FI without hunger) (P < .05). At the child level, a significant association was observed between low food security and poorer grades in all subjects studied, whereas for very low food security, this relationship was significant only for mathematics, reading, and science (P < .05). Food insecurity without hunger (odds ratio = 2.56; 95% confidence interval, 1.05-6.23) and low food security (odds ratio = 4.41; 95% confidence interval, 1.58-12.23) were associated with overweight only in girls. The findings confirm the need for policies and programs to improve students' dietary quality and food security to improve their health as well as educational attainment. Future research is needed to explore further the association between food security and academic performance. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  13. Long-term outcome of palliative therapy for gastric outlet obstruction caused by unresectable gastric cancer in patients with good performance status: endoscopic stenting versus surgery.

    Science.gov (United States)

    No, Jin Hee; Kim, Sang Woo; Lim, Chul-Hyun; Kim, Jin Su; Cho, Yu Kyung; Park, Jae Myung; Lee, In Seok; Choi, Myung-Gyu; Choi, Kyu Yong

    2013-07-01

    In patients with gastric outlet obstruction (GOO) caused by gastric cancer, choosing between self-expandable metal stent (SEMS) placement and gastrojejunostomy (GJJ) is of concern, especially in those with good performance status. To compare SEMS placement and GJJ. Retrospective study. Single tertiary referral center. Patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 who had GOO caused by unresectable gastric cancer. SEMS placement and GJJ. Success rate, adverse events, patency, and survival duration. Of the 113 patients in this study, 72 underwent SEMS placement and 41 underwent GJJ. The 2 groups did not differ in the technical and clinical success and incidence of early adverse events. However, the rate of late adverse events was significantly higher in the SEMS group (44.4% vs 12.2%; P gastric cancer in patients with a good performance status, especially ECOG 0-1. Copyright © 2013 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  14. STATUS KESEHATAN GIGI, PERFORMED TREATMENT INDEX DAN REQUIRED TREATMENT INDEX ANAK SEKOLAH DASAR DI KABUPATEN CIANJUR, KARAWANG DAN SERANG

    Directory of Open Access Journals (Sweden)

    Magdarina D. Agtini

    2012-10-01

    Full Text Available Community dental health status for permanent teeth in determined by the DMF-T (Decayed Misssing and Filled Teeth. The DMF-T in a number of industrialized nations shows a tendency to drop while the trend in developing nations is increasing. In Indonesia dental caries is still the foremost problem in oral and dental diseases, Prevalence of dental caries is around 85%-99%. The DMF-T is varied, reflect geographic and ages variations. In three decade's the intensity of dental caries is increasing with each decade, 0,70 DMF-T in 1970 to be 2,30 DMF-T in 1980 and 2,70 DMF-Tin 1990. Goal of dental caries control for 2010 is DMF-T ≤ 1 for 12 years age group. Baseline study is therefore necessary to ascertain DMF-T, PTI (Performed Treatment Index and RTI (Required Treatment Index. The study was implemented in the districts of Cianjur, Karawang and Serang in West Java for two years. The study design was cohort. The respondents  were 1200 pupils aged 8 years, randomly selected with a signifzcantcy grade of p < 0,05 and power of 0,20. The study results showed average of DMF-T at the beginning was 1,52 ± 1,21, and after two years the DMF-T was 2.45 ± 1.51 comprise only of the decayed component, and There was significant different (p=0,000. The DMF-T was low WHO criteria, nevertheless the PTI (1,2% was very low and the RTI (98% was very high. The DMF_T average shows a tendency to increase, with D as the largest component and F (Filling the smallest one. The control of dental caries faces several problems, like the limited number of manpower and facilities, and limited supply of water and electricity incertain areas. Therefore treatment of dental caries with GIC fillings using the ART method should be taken into consideration receive the necessary attention.   Key words:  Status kesehatan gigi, Karies, Performed treatment Index (PTI,  Required Treatment  Index (RTI

  15. Effect of 12-Week Vitamin D Supplementation on 25[OH]D Status and Performance in Athletes with a Spinal Cord Injury

    Directory of Open Access Journals (Sweden)

    Joelle Leonie Flueck

    2016-09-01

    Full Text Available (1 Background: studies with able-bodied athletes showed that performance might possibly be influenced by vitamin D status. Vitamin D seems to have a direct impact on neuromuscular function by docking on vitamin D receptors in the muscle tissue. Additionally, a high prevalence of vitamin D deficiency was shown not only in infants and in the elderly but also in healthy adults and spinal cord injured individuals. Therefore, the aim of our study was to investigate whether a vitamin D dose of 6000 IU daily over 12 weeks would be sufficient to increase vitamin D status in indoor wheelchair athletes to a normal or optimal vitamin D level and whether vitamin D deficiency is associated with an impairment in muscle performance in these individuals; (2 Methods: vitamin D status was assessed in indoor elite wheelchair athletes in order to have a baseline measurement. If vitamin D status was below 75 nmol/L, athletes were supplemented with 6000 IU of vitamin D daily over 12 weeks. A vitamin D status over 75 nmol/L was supplemented with a placebo supplement. Vitamin D status, as well as a Wingate test and an isokinetic dynamometer test, were performed at baseline and after six and 12 weeks; (3 Results: 20 indoor elite wheelchair athletes participated in this double-blind study. All of these athletes showed an insufficient vitamin D status at baseline and were, therefore, supplemented with vitamin D. All athletes increased vitamin D status significantly over 12 weeks and reached an optimal level. Wingate performance was not significantly increased. Isokinetic dynamometer strength was significantly increased but only in the non-dominant arm in isometric and concentric elbow flexion; (4 Conclusion: a dose of 6000 IU of vitamin D daily over a duration of 12 weeks seems to be sufficient to increase vitamin D status to an optimal level in indoor wheelchair athletes. It remains unclear, whether upper body performance or muscle strength and vitamin D status are

  16. Multi-stage-flash desalination plants of relative small performance with integrated pressurized water reactors as a nuclear heat source

    International Nuclear Information System (INIS)

    Petersen, G.; Peltzer, M.

    1977-01-01

    In the Krupp-GKSS joint study MINIPLEX the requirements for seawater-desalination plants with a performance in the range of 10 000 to 80 000 m 3 distillate per day heated by a nuclear reactor are investigated. The reactor concept is similar to the Integrated Pressurized Water Reactor (IPWR) of the nuclear ship OTTO HAHN. The design study shows that IPWR systems have specific advantages up to 200 MWth compared to other reactor types at least being adapted for single- and dual-purpose desalination plants. The calculated costs of the desalinated water show that due to fuel cost advantages of reactors small and medium nuclear desalination plants are economically competetive with oil-fired plants since the steep rise of oil price in autumn 1973. (author)

  17. Performance and Stability Characteristics of a Uni-Element Swirl Injector for Oxygen-Rich Stage Combustion Cycles

    Science.gov (United States)

    Pal, S.; Kalitan, D.; Woodward, R. D.; Santoro, R. J.

    2004-01-01

    A uni-element liquid propellant combustion performance and instability study for liquid RP-1 and hot oxygen-rich pre-burner products was conducted, at a chamber pressure of about 1000 psi. using flush and recessed swirl injectors. High-frequency pressure transducer measurements were analyzed to yield the characteristic frequencies which were compared to expected frequencies of the chamber. Modes, which were discovered to be present within the main chamber included, the first longitudinal, detected at approximately 1950 Hz, and the second longitudinal mode at approximately 3800 Hz. An additional first longitudinal quarter wave mode was measured at a frequency of approximately 23000 Hz for the recessed swirl injector configuration. The characteristic instabilities resulting from these experiments were relatively weak averaging 0.2% to 0.3% of the chamber pressure.

  18. Effect of Different Levels of Methionine on Performance of Khorasan Station Native Hens at Different Production Stages

    Directory of Open Access Journals (Sweden)

    A Hesabi Nameghi

    2012-02-01

    To investigate the effects of different levels of the amino acid methionine(Met on performance of birds native Khorasan province, an experiment using 300 pieces of chicken native Station Native chickens Khorasan in the form of designs completely randomized design with 6 treatments, 5 replicates and 10 chickens in each replicate from age 26 till 52 weeks implemented. 6 treatments follows that the first treatment of Met to 0.22% received the basal diet( control and other treatments to Met level of 0.1% in each treatment and were increased so that the six birds different Met (0.22,0.32,0.42,0.52,0.62 and 0.72 percent received. The results showed that the Met levels increase the total weight of eggs produced in the experimental period (P

  19. Associations of vitamin D status, bone health and anthropometry, with gross motor development and performance of school-aged Indian children who were born at term with low birth weight

    Science.gov (United States)

    Filteau, Suzanne; Rehman, Andrea M; Yousafzai, Aisha; Chugh, Reema; Kaur, Manpreet; Sachdev, H P S; Trilok-Kumar, Geeta

    2016-01-01

    Objectives There is little information regarding motor development of children born at term with low birth weight (LBW), a group that constitutes a large proportion of children in South Asia. We used data from infancy and at school age from a LBW cohort to investigate children's motor performance using causal inference. Design Cross-sectional follow-up study. Setting Delhi, India. Participants We recruited 912 children aged 5 years who had participated in a trial of vitamin D for term LBW infants in the first 6 months of life. Outcome measures We focused on gross motor development, using the Ages and Stages Questionnaire (ASQ) gross motor scale and several measures of motor performance. We examined the effects on these of current anthropometry, vitamin D status and bone health, controlling for age, sex, season of interview, socioeconomic variables, early growth, recent morbidity, sun exposure and animal food intake. Results In adjusted analyses, stunted children (height-for-age Z (HAZ) <−2) took longer to run 20 m (0.52 s, 95% CI 0.35 to 0.70; p<0.001) and had greater odds of a failing score on the ASQ (OR 3.00, 95% CI 1.41 to 6.38, p=0.004). Greater arm muscle area was associated with faster run time, and the ability to perform more stands and squats in 15 s. Poorer vitamin D status was associated with the ability to perform more stands and squats. Lower tibia ultrasound Z score was associated with greater hand grip strength. Early growth and current body mass index had no associations with motor outcomes. Conclusions Current HAZ and arm muscle area showed the strongest associations with gross motor outcomes, likely due to a combination of simple physics and factors associated with stunting. The counterintuitive inverse associations of tibia health and vitamin D status with outcomes may require further research. PMID:26747034

  20. The ICESat-2 mission: design, status, applications and pre-launch performance assessments for monitoring cryopsheric changes

    Science.gov (United States)

    Neumann, T.; Markus, T.; Csatho, B. M.; Martino, A. J.

    2013-12-01

    NASA's Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) is the next-generation orbiting laser altimeter, following the ICESat mission, which operated between 2003 and 2009. Its primary aim is to monitor sea-ice thickness and ice sheet elevation change at scales from outlet glaciers to the entire ice sheet, and enable global assessment of vegetation canopy height as established by ICESat. ICESat-2 is now in Phase C (Design and Development). It is scheduled to launch in 2016 on a Delta II rocket from Vandenberg Air Force Base in California. ICESat-2 will carry the Advanced Topographic Laser Altimeter System (ATLAS) and collect data to a latitudinal limit of 88 degrees. In contrast to Geoscience Laser Altimeter System (GLAS) on ICESat, ATLAS employs a 6-beam micro-pulse laser photon-counting approach. It uses a high repetition rate (10 kHz; resulting in 70 cm footprint spacing on the ground along the direction of travel) low-power laser in conjunction with single-photon sensitive detectors to measure ranges using 532 nm (green) laser light. In the polar regions, the 91-day repeat orbit pattern with a roughly monthly sub-cycle is designed to monitor seasonal and interannual variations of Greenland and Antarctic ice sheet elevations and monthly sea ice thickness changes. Dense ground-tracks over the rest of the globe achieved through a systematic sequence of off-nadir pointing (resulting in < 2 km ground-track spacing at the equator after two years) will enable measurements of land topography and vegetation canopy heights, allowing estimates of biomass and carbon in above-ground vegetation. While the ICESat-2 mission was optimized for cryospheric science, elevation measurements will be collected over land and oceans as well as histograms of backscatter from the atmosphere. These observations will provide a wealth of opportunities in addition to the primary science objectives, ranging from the retrieval of cloud properties, to river stages, to snow cover, to land

  1. Hybrid maize breeding with doubled haploids. IV. Number versus size of crosses and importance of parental selection in two-stage selection for testcross performance.

    Science.gov (United States)

    Wegenast, Thilo; Longin, C Friedrich H; Utz, H Friedrich; Melchinger, Albrecht E; Maurer, Hans Peter; Reif, Jochen C

    2008-07-01

    Parental selection influences the gain from selection and the optimum allocation of test resources in breeding programs. We compared two hybrid maize (Zea mays L.) breeding schemes with evaluation of testcross progenies: (a) doubled haploid (DH) lines in both stages (DHTC) and (b) S(1) families in the first stage and DH lines within S(1) families in the second stage (S(1)TC-DHTC). Our objectives were to (1) determine the optimum allocation regarding the number of crosses, S(1) families, DH lines, and test locations, (2) investigate the impact of parental selection on the optimum allocation and selection gain (DeltaG), and (3) compare the maximum DeltaG achievable with each breeding scheme. Selection gain was calculated by numerical integration. Different assumptions were made regarding the budget, variance components, correlation between the mean phenotypic performance of the parents and the mean genotypic value of the testcross performance of their progenies (rho( P )), and the composition of the finally selected test candidates. In comparison with randomly chosen crosses, maximum DeltaG was largely increased with parental selection in both breeding schemes. With an increasing correlation rho( P ), this superiority increased strongly, while the optimum number of crosses decreased in favor of an increased number of test candidates within crosses. Thus, concentration on few crosses among the best parental lines might be a promising approach for short-term success in advanced cycle breeding. Breeding scheme S(1)TC-DHTC led to a larger DeltaG but had a longer cycle length than DHTC. However, with further improvements in the DH technique and the realization of more than two generations per year, early testing of S(1) families prior to production of DH lines would become very attractive in hybrid maize breeding.

  2. Two-stage anaerobic and post-aerobic mesophilic digestion of sewage sludge: Analysis of process performance and hygienization potential.

    Science.gov (United States)

    Tomei, M Concetta; Mosca Angelucci, Domenica; Levantesi, Caterina

    2016-03-01

    Sequential anaerobic-aerobic digestion has been demonstrated to be effective for enhanced sludge stabilization, in terms of increased solid reduction and improvement of sludge dewaterability. In this study, we propose a modified version of the sequential anaerobic-aerobic digestion process by operating the aerobic step under mesophilic conditions (T=37 °C), in order to improve the aerobic degradation kinetics of soluble and particulate chemical oxygen demand (COD). Process performance has been assessed in terms of "classical parameters" such as volatile solids (VS) removal, biogas production, COD removal, nitrogen species, and polysaccharide and protein fate. The aerobic step was operated under intermittent aeration to achieve nitrogen removal. Aerobic mesophilic conditions consistently increased VS removal, providing 32% additional removal vs. 20% at 20 °C. Similar results were obtained for nitrogen removal, increasing from 64% up to 99% at the higher temperature. Improved sludge dewaterability was also observed with a capillary suction time decrease of ~50% during the mesophilic aerobic step. This finding may be attributable to the decreased protein content in the aerobic digested sludge. The post-aerobic digestion exerted a positive effect on the reduction of microbial indicators while no consistent improvement of hygienization related to the increased temperature was observed. The techno-economic analysis of the proposed digestion layout showed a net cost saving for sludge disposal estimated in the range of 28-35% in comparison to the single-phase anaerobic digestion. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Performed and perceived walking ability in relation to the Expanded Disability Status Scale in persons with multiple sclerosis

    DEFF Research Database (Denmark)

    Langeskov-Christensen, D; Feys, P; Baert, I

    2017-01-01

    BACKGROUND: The severity of walking impairment in persons with multiple sclerosis (pwMS) at different levels on the expanded disability status scale (EDSS) is unclear. Furthermore, it is unclear if the EDSS is differently related to performed- and perceived walking capacity tests. AIMS: To quantify...... walking impairment and perceived impact of MS on walking according to EDSS scores and to examine the relations between these parameters in pwMS. METHODS: EDSS was collected by neurologists and walking was assessed by the timed 25ft walk test (T25FWT), two minute walk test (2MWT), six minute walk test (6......MWT) and the 12-item MS walking scale (MSWS-12) in 474 PwMS with mild (EDSS 1-4: n=200) to moderate (EDSS 4.5-6.5: n=274) MS. Magnitude of walking impairment was calculated and related to EDSS. RESULTS: Compared to predicted values in healthy controls, walking speed was reduced by 41.5±25.8% in the 6...

  4. Effects of Wine by-Products on Growth Performance, Complete Blood Count and Total Antioxidant Status in Broilers

    Directory of Open Access Journals (Sweden)

    SM Pascariu

    Full Text Available ABSTRACT This study aimed to investigate the effect of whole grape pomace (GP, grape seed (GS and grape pomace polyphenolic extract (GPEP on growth performance, total antioxidant status (TAS and complete blood count (CBC of 40-day-old chicks (hybrid Cobb 500. A total of 432 unsexed one-day-old chicks were divided into six groups: control (CON and five experimental groups, 10 g/kg GP, 20 g/kg GP, 5 g/kg GS, 10 g/kg GS and 15 mL/L GPEP. The results showed a higher increase in growing rate in 5 g/kg GS group, from the first week of the chicks’ life throughout their growth, the average body weight of the chicks being significantly higher (p0.05 at 40 days of age. As a conclusion, the amount of 5 g/kg seeds, 10 g/kg and 20 g/kg pomace, can be added to the diet of the broilers, the dose of 5 g/kg seeds in the diet offering advantages in growing rate and feed valorization in weight gain.

  5. Microwave SQUID Multiplexing of Metallic Magnetic Calorimeters: Status of Multiplexer Performance and Room-Temperature Readout Electronics Development

    Science.gov (United States)

    Wegner, M.; Karcher, N.; Krömer, O.; Richter, D.; Ahrens, F.; Sander, O.; Kempf, S.; Weber, M.; Enss, C.

    2018-02-01

    To our present best knowledge, microwave SQUID multiplexing (μ MUXing) is the most suitable technique for reading out large-scale low-temperature microcalorimeter arrays that consist of hundreds or thousands of individual pixels which require a large readout bandwidth per pixel. For this reason, the present readout strategy for metallic magnetic calorimeter (MMC) arrays combining an intrinsic fast signal rise time, an excellent energy resolution, a large energy dynamic range, a quantum efficiency close to 100% as well as a highly linear detector response is based on μ MUXing. Within this paper, we summarize the state of the art in MMC μ MUXing and discuss the most recent results. This particularly includes the discussion of the performance of a 64-pixel detector array with integrated, on-chip microwave SQUID multiplexer, the progress in flux ramp modulation of MMCs as well as the status of the development of a software-defined radio-based room-temperature electronics which is specifically optimized for MMC readout.

  6. Effect of Cocoa Butter and Sunflower Oil Supplementation on Performance, Immunoglobulin, and Antioxidant Vitamin Status of Rats

    Directory of Open Access Journals (Sweden)

    Ebru Yıldırım

    2014-01-01

    Full Text Available This study investigated the effects of cocoa butter and sunflower oil alone and in combination on performance, some biochemical parameters, immunoglobulin, and antioxidant vitamin status in Wistar rats. Forty-eight male rats were assigned to four groups, consisting of 12 rats with 3 replicates. Control received balanced rat diet without oil, cocoa butter group received 3.5% cocoa butter, sunflower oil group received 3.5% sunflower oil, the last group received 1.75% sunflower oil + 1.75% cocoa butter supplementation in the rat diet f