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Sample records for stably stratified fluid

  1. Dynamics of mixed convective-stably-stratified fluids

    Science.gov (United States)

    Couston, L.-A.; Lecoanet, D.; Favier, B.; Le Bars, M.

    2017-09-01

    We study the dynamical regimes of a density-stratified fluid confined between isothermal no-slip top and bottom boundaries (at temperatures Tt and Tb) via direct numerical simulation. The thermal expansion coefficient of the fluid is temperature dependent and chosen such that the fluid density is maximum at the inversion temperature Tb>Ti>Tt . Thus, the lower layer of the fluid is convectively unstable while the upper layer is stably stratified. We show that the characteristics of the convection change significantly depending on the degree of stratification of the stable layer. For strong stable stratification, the convection zone coincides with the fraction of the fluid that is convectively unstable (i.e., where T >Ti ), and convective motions consist of rising and sinking plumes of large density anomaly, as is the case in canonical Rayleigh-Bénard convection; internal gravity waves are generated by turbulent fluctuations in the convective layer and propagate in the upper layer. For weak stable stratification, we demonstrate that a large fraction of the stable fluid (i.e., with temperature T phenomenological description of the transition between the regimes of plume-dominated and entrainment-dominated convection through analysis of the differences in the heat transfer mechanisms, kinetic energy density spectra, and probability density functions for different stratification strengths. Importantly, we find that the effect of the stable layer on the convection decreases only weakly with increasing stratification strength, meaning that the dynamics of the stable layer and convection should be studied self-consistently in a wide range of applications.

  2. Numerical Simulations of Stably Stratified Fluid Flow Using Compact Finite-Difference Schemes

    Science.gov (United States)

    Bodnár, T.; Fraunié, Ph.; Kozel, K.

    2010-09-01

    The aim of this paper is to present the class of high order compact schemes in the context of numerical simulation of stratified flow. The numerical schemes presented here are based on the approach outlined in Lele [1]. The numerical model presented in this contribution is based on the solution of the Boussinesq approximation by a finite-difference scheme. The numerical scheme itself follows the principle of semi-discretization, with high order compact discretization in space, while the time integration is carried out by suitable Runge-Kutta time-stepping scheme. In the case presented here the steady flow was considered and thus the artificial compressibility method was used to resolve the pressure from the modified continuity equation. The test case used to demonstrate the capabilities of the selected model consists of the flow of stably stratified fluid over low, smooth hill.

  3. Stably-stratified wall-bounded turbulence

    Science.gov (United States)

    Hadi Sichani, Pejman; Zonta, Francesco; Obabko, Aleksandr; Soldati, Alfredo

    2017-11-01

    Stably-stratified (bottom-up cooling) turbulent flows are encountered in a number of industrial applications, environmental processes and geophysical flows. Turbulent entrainment and mixing across density interfaces in terrestrial water bodies (oceans, lakes and rivers) and in industrial heat transfer equipments are just some important examples of stably-stratified flows. In this work we use Direct Numerical Simulation to investigate the fundamental physics of stably-stratified channel turbulence under Boussinesq and Non-Oberbeck-Boussinesq (NOB) conditions. Compared to the neutrally-buoyant case, in the stably-stratified case active turbulence survives only in the near-wall region and coexists with internal gravity waves (IGW) moving in the core region of the channel. This induces a general suppression of turbulence levels, momentum and buoyancy fluxes. Our results show also that NOB effects may be important when the flow is subject to large temperature gradients. The most striking feature observed in case of NOB conditions is the generation of a strong flow asymmetry with possible local flow laminarization in the near wall region.

  4. Large eddy simulation of stably stratified turbulence

    International Nuclear Information System (INIS)

    Shen Zhi; Zhang Zhaoshun; Cui Guixiang; Xu Chunxiao

    2011-01-01

    Stably stratified turbulence is a common phenomenon in atmosphere and ocean. In this paper the large eddy simulation is utilized for investigating homogeneous stably stratified turbulence numerically at Reynolds number Re = uL/v = 10 2 ∼10 3 and Froude number Fr = u/NL = 10 −2 ∼10 0 in which u is root mean square of velocity fluctuations, L is integral scale and N is Brunt-Vaïsälä frequency. Three sets of computation cases are designed with different initial conditions, namely isotropic turbulence, Taylor Green vortex and internal waves, to investigate the statistical properties from different origins. The computed horizontal and vertical energy spectra are consistent with observation in atmosphere and ocean when the composite parameter ReFr 2 is greater than O(1). It has also been found in this paper that the stratification turbulence can be developed under different initial velocity conditions and the internal wave energy is dominated in the developed stably stratified turbulence.

  5. Turbulent Mixing in Stably Stratified Flows

    Science.gov (United States)

    2008-03-01

    Turbulent fluid motions are typically characterized by several features including randomness in both space and time, vorticity, an energy cascade ...drawback of this method is that the portion of the flow identified as a turbulent structure is dependent on the type of wavelet filter used (e.g., Haar ...the mesoscale variability of the atmosphere. J. Atmos. Sci., 40:749-761, 1983. E. Lindborg. The energy cascade in a strongly stratified fluid. J

  6. Analytical and numerical study of natural convection in a stably stratified fluid along vertical plates and cylinders with temporally-periodic surface temperature variations

    International Nuclear Information System (INIS)

    Shapiro, A.; Fedorovich, E.

    2005-01-01

    This paper describes one-dimensional (parallel) laminar and transitional regimes of natural convection in a viscous stably stratified fluid due to temporally-periodic variations in the surface temperature of infinite vertical plates and cylinders. Analytical solutions are obtained for the periodic laminar regime for arbitrary values of stratification, Prandtl number and forcing frequency. The solutions for plates and cylinders are qualitatively similar and show that (i) the flows are composed of two waves that decay exponentially with distance from the surface; a fast long wave and a slow short wave, (ii) for forcing frequencies less than the natural frequency, both waves propagate away from the surface, while (iii) for forcing frequencies less than this natural frequency, the short wave propagates away from the surface while the long wave propagates toward the surface. The analytical results are complemented, for the plate problem, with three-dimensional numerical simulations of flows that start from rest and are suddenly subjected to a periodic thermal forcing. The numerical results depict the transient (start-up) stage of the laminar flow and the approach to the periodicity, and confirm that the analytical solutions provide the appropriate description of the periodic regime for the laminar convection case. Preliminary numerical data are presented for transition from the laminar to turbulent convection. (authors)

  7. Turbulent structure of stably stratified inhomogeneous flow

    Science.gov (United States)

    Iida, Oaki

    2018-04-01

    Effects of buoyancy force stabilizing disturbances are investigated on the inhomogeneous flow where disturbances are dispersed from the turbulent to non-turbulent field in the direction perpendicular to the gravity force. Attaching the fringe region, where disturbances are excited by the artificial body force, a Fourier spectral method is used for the inhomogeneous flow stirred at one side of the cuboid computational box. As a result, it is found that the turbulent kinetic energy is dispersed as layered structures elongated in the streamwise direction through the vibrating motion. A close look at the layered structures shows that they are flanked by colder fluids at the top and hotter fluids at the bottom, and hence vertically compressed and horizontally expanded by the buoyancy related to the countergradient heat flux, though they are punctuated by the vertical expansion of fluids at the forefront of the layered structures, which is related to the downgradient heat flux, indicating that the layered structures are gravity currents. However, the phase between temperature fluctuations and vertical velocity is shifted by π/2 rad, indicating that temperature fluctuations are generated by the propagation of internal gravity waves.

  8. Optimal energy growth in a stably stratified shear flow

    Science.gov (United States)

    Jose, Sharath; Roy, Anubhab; Bale, Rahul; Iyer, Krithika; Govindarajan, Rama

    2018-02-01

    Transient growth of perturbations by a linear non-modal evolution is studied here in a stably stratified bounded Couette flow. The density stratification is linear. Classical inviscid stability theory states that a parallel shear flow is stable to exponentially growing disturbances if the Richardson number (Ri) is greater than 1/4 everywhere in the flow. Experiments and numerical simulations at higher Ri show however that algebraically growing disturbances can lead to transient amplification. The complexity of a stably stratified shear flow stems from its ability to combine this transient amplification with propagating internal gravity waves (IGWs). The optimal perturbations associated with maximum energy amplification are numerically obtained at intermediate Reynolds numbers. It is shown that in this wall-bounded flow, the three-dimensional optimal perturbations are oblique, unlike in unstratified flow. A partitioning of energy into kinetic and potential helps in understanding the exchange of energies and how it modifies the transient growth. We show that the apportionment between potential and kinetic energy depends, in an interesting manner, on the Richardson number, and on time, as the transient growth proceeds from an optimal perturbation. The oft-quoted stabilizing role of stratification is also probed in the non-diffusive limit in the context of disturbance energy amplification.

  9. Maximal mixing rate in turbulent stably stratified Couette flow

    Science.gov (United States)

    Caulfield, C. P.; Kerswell, R. R.

    2001-11-01

    A rigorous upper bound on the long-time-averaged vertical buoyancy flux is derived from the Navier-Stokes equations for a Boussinesq fluid confined between two parallel horizontal plates a distance d apart, maintained at a constant statically stabilizing temperature difference Δ T and driven at a constant relative velocity Δ U. The upper bound on the volume and long-time-averaged vertical buoyancy flux \\cal B := limt arrow ∞ 1/t int^t0 g/ρ0 dtildet is \\cal B <= \\cal B_max=(1-16√2/Re) (Δ U)^3 /(64 √2d) where Re=Δ Ud/ν and ρ0 is some reference density. Significantly, \\cal B_max is independent of the bulk Richardson number of the flow and is achieved by an optimal solution with a mixing efficiency (or flux Richardson number) which approaches 0.5 as the Reynolds number becomes large. The time-averaged turbulent dissipation of kinetic energy and the time-averaged vertical buoyancy flux are then in equipartition for the optimising flow.

  10. Turbulent jet erosion of a stably stratified gas layer in a nuclear reactor test containment

    Energy Technology Data Exchange (ETDEWEB)

    Ishay, Liel [Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105 (Israel); Bieder, Ulrich [Commissariat à l’énergie atomique et aux énergies alternatives, Centre de SACLAY DEN/SAC/DANS/DM2S/STMF/LMSF, F-91191 Gif-sur-Yvette (France); Ziskind, Gennady [Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105 (Israel); Rashkovan, Alex, E-mail: rashbgu@gmail.com [Physics Department, Nuclear Research Center Negev (NRCN), PO Box 9001, Beer-Sheva 84190 (Israel)

    2015-10-15

    Highlights: • We model stably stratified layer erosion by vertical turbulent round jet. • Separate effect studies are performed as a platform for choosing modeling approach. • A test performed in MISTRA facility, CEA, Saclay is modeled using Fluent and Trio-U codes. • The proposed modeling approach showed good agreement with the MISTRA facility LOWMA-3 test. - Abstract: A number of integral and separate effect experiments were performed in the last two decades for validation of containment computational tools. The main goal of these benchmark experiments was to assess the ability of turbulence models and computational fluid dynamics codes to predict hydrogen concentration distribution and steam condensation rate in a nuclear reactor containment in the course of severe accidents. It appears from the published literature that the predictive capability of the existing computational tools still needs to be improved. This work examines numerically the temporal evolution of helium concentration in the experiment called LOWMA-3, performed in the MISTRA facility of CEA-Saclay, France. In the experiment, helium is used to mimic hydrogen of a real-case accident. The aim of this separate effect experiment, where steam condensation was not involved, is to predict helium concentration field. The conditions of the experiment are such that both the momentum transport and molecular diffusion contributions to the mixing process are of the same order of magnitude (Fr ∼ 1). A commercial CFD code, Fluent, and a CEA in-house code, Trio-U, are used for flow and helium concentration fields temporal evolution prediction in the present study. The preliminary separate effect studies provide guidance to an optimal modeling approach for the LOWMA-3 experiment. Temporal evolution of helium concentration in the stratification layer is shown, and a comparison to the experiment is discussed. It is shown that correct modeling of the round jet flowfield is essential for a reliable

  11. Turbulent jet erosion of a stably stratified gas layer in a nuclear reactor test containment

    International Nuclear Information System (INIS)

    Ishay, Liel; Bieder, Ulrich; Ziskind, Gennady; Rashkovan, Alex

    2015-01-01

    Highlights: • We model stably stratified layer erosion by vertical turbulent round jet. • Separate effect studies are performed as a platform for choosing modeling approach. • A test performed in MISTRA facility, CEA, Saclay is modeled using Fluent and Trio-U codes. • The proposed modeling approach showed good agreement with the MISTRA facility LOWMA-3 test. - Abstract: A number of integral and separate effect experiments were performed in the last two decades for validation of containment computational tools. The main goal of these benchmark experiments was to assess the ability of turbulence models and computational fluid dynamics codes to predict hydrogen concentration distribution and steam condensation rate in a nuclear reactor containment in the course of severe accidents. It appears from the published literature that the predictive capability of the existing computational tools still needs to be improved. This work examines numerically the temporal evolution of helium concentration in the experiment called LOWMA-3, performed in the MISTRA facility of CEA-Saclay, France. In the experiment, helium is used to mimic hydrogen of a real-case accident. The aim of this separate effect experiment, where steam condensation was not involved, is to predict helium concentration field. The conditions of the experiment are such that both the momentum transport and molecular diffusion contributions to the mixing process are of the same order of magnitude (Fr ∼ 1). A commercial CFD code, Fluent, and a CEA in-house code, Trio-U, are used for flow and helium concentration fields temporal evolution prediction in the present study. The preliminary separate effect studies provide guidance to an optimal modeling approach for the LOWMA-3 experiment. Temporal evolution of helium concentration in the stratification layer is shown, and a comparison to the experiment is discussed. It is shown that correct modeling of the round jet flowfield is essential for a reliable

  12. Free Falling in Stratified Fluids

    Science.gov (United States)

    Lam, Try; Vincent, Lionel; Kanso, Eva

    2017-11-01

    Leaves falling in air and discs falling in water are examples of unsteady descents due to complex interaction between gravitational and aerodynamic forces. Understanding these descent modes is relevant to many branches of engineering and science such as estimating the behavior of re-entry space vehicles to studying biomechanics of seed dispersion. For regularly shaped objects falling in homogenous fluids, the motion is relatively well understood. However, less is known about how density stratification of the fluid medium affects the falling behavior. Here, we experimentally investigate the descent of discs in both pure water and in stable linearly stratified fluids for Froude numbers Fr 1 and Reynolds numbers Re between 1000 -2000. We found that stable stratification (1) enhances the radial dispersion of the disc at landing, (2) increases the descent time, (3) decreases the inclination (or nutation) angle, and (4) decreases the fluttering amplitude while falling. We conclude by commenting on how the corresponding information can be used as a predictive model for objects free falling in stratified fluids.

  13. Reduction of vertical transport in two-dimensional stably stratified forced shear flows

    Science.gov (United States)

    Toqué, Nathalie; Lignières, François; Vincent, Alain

    2006-04-01

    The effect of stable stratification on the vertical transport of passive contaminants in forced, stationary, two-dimensional (2D) and inhomogeneous shear turbulence is investigated numerically. The mean flow consists of several superimposed parallel sheared layers in a stably stratified medium. We find that, as stratification increases, the vertical transport decreases much faster than predicted by mixing length estimates. For the highest stratification, particles vertical dispersion nearly vanishes. The proposed interpretation emphasizes the role of weakly sheared layers where the relative increase of the mean horizontal velocity with respect to the root-mean-square (rms) vertical velocity causes the decrease of the Lagrangian correlation timescale.

  14. Turbulent Mechanical Energy Budget in Stably Stratified Baroclinic Flows over Sloping Terrain

    Science.gov (United States)

    Łobocki, Lech

    2017-09-01

    Analysis of second-moment budget equations in a slope-oriented coordinate frame exhibits the pathways of exchange between the potential energy of mean flow and the total turbulent mechanical energy. It is shown that this process is controlled by the inclination of the potential temperature gradient. Hence, this parameter should be considered in studies of turbulence in slope flows as well as the slope inclination. The concept of turbulent potential energy is generalized to include baroclinicity, and is used to explain the role of along-slope turbulent heat flux in energy conversions. A generalization of static stability criteria for baroclinic conditions is also proposed. In addition, the presence of feedback between the turbulent heat flux and the temperature variance in stably-stratified flows is identified, which implies the existence of oscillatory modes characterized by the Brunt-Väisäla frequency.

  15. A Case Study of Offshore Advection of Boundary Layer Rolls over a Stably Stratified Sea Surface

    Directory of Open Access Journals (Sweden)

    Nina Svensson

    2017-01-01

    Full Text Available Streaky structures of narrow (8-9 km high wind belts have been observed from SAR images above the Baltic Sea during stably stratified conditions with offshore winds from the southern parts of Sweden. Case studies using the WRF model and in situ aircraft observations indicate that the streaks originate from boundary layer rolls generated over the convective air above Swedish mainland, also supported by visual satellite images showing the typical signature cloud streets. The simulations indicate that the rolls are advected and maintained at least 30–80 km off the coast, in agreement with the streaks observed by the SAR images. During evening when the convective conditions over land diminish, the streaky structures over the sea are still seen in the horizontal wind field; however, the vertical component is close to zero. Thus advected feature from a land surface can affect the wind field considerably for long times and over large areas in coastal regions. Although boundary layer rolls are a well-studied feature, no previous study has presented results concerning their persistence during situations with advection to a strongly stratified boundary layer. Such conditions are commonly encountered during spring in coastal regions at high latitudes.

  16. Phenomenology of two-dimensional stably stratified turbulence under large-scale forcing

    KAUST Repository

    Kumar, Abhishek

    2017-01-11

    In this paper, we characterise the scaling of energy spectra, and the interscale transfer of energy and enstrophy, for strongly, moderately and weakly stably stratified two-dimensional (2D) turbulence, restricted in a vertical plane, under large-scale random forcing. In the strongly stratified case, a large-scale vertically sheared horizontal flow (VSHF) coexists with small scale turbulence. The VSHF consists of internal gravity waves and the turbulent flow has a kinetic energy (KE) spectrum that follows an approximate k−3 scaling with zero KE flux and a robust positive enstrophy flux. The spectrum of the turbulent potential energy (PE) also approximately follows a k−3 power-law and its flux is directed to small scales. For moderate stratification, there is no VSHF and the KE of the turbulent flow exhibits Bolgiano–Obukhov scaling that transitions from a shallow k−11/5 form at large scales, to a steeper approximate k−3 scaling at small scales. The entire range of scales shows a strong forward enstrophy flux, and interestingly, large (small) scales show an inverse (forward) KE flux. The PE flux in this regime is directed to small scales, and the PE spectrum is characterised by an approximate k−1.64 scaling. Finally, for weak stratification, KE is transferred upscale and its spectrum closely follows a k−2.5 scaling, while PE exhibits a forward transfer and its spectrum shows an approximate k−1.6 power-law. For all stratification strengths, the total energy always flows from large to small scales and almost all the spectral indicies are well explained by accounting for the scale-dependent nature of the corresponding flux.

  17. The turbulent decay of trailing vortex pairs in stably stratified environments

    Energy Technology Data Exchange (ETDEWEB)

    Holzaepfel, F.; Gerz, T.; Baumann, R.

    2000-03-01

    The decay of trailing vortex pairs in thermally stably stratified environments is investigated by means of large eddy simulations. Results of in-situ measurements in the wakes of different aircraft are used to find appropriate intitializations for the simulation of wake turbulence in the quiescent atmosphere. Furthermore, cases with weak atmospheric turbulence are investigated. It is shown that the early development of the vortices is not affected by turbulence and develops almost identically as in 2D simulations. In a quiescent atmosphere the subsequent vortex decay is controlled by the interaction of short-wave disturbances, owing to the aircraft induced turbulence, and baroclinic vorticity, owing to stable stratification. As a consequence, vertical vorticity streaks between the vortices are induced which are substantially intensified by vortex stretching and finally lead to rapid turbulent wake-vortex decay. When in addition also atmospheric turbulence is present, the long-wave instability is dominantly promoted. For very strong stratification (Fr < 1) it is observed that wake vortices may rebound but lose most of their strength before reaching the flight level. Finally, the simulation results are compared to the predictive capabilities of Greene's approximate model. (orig.)

  18. Direct numerical simulations of stably-stratified sheared turbulence: Implications for oceanic mixing

    Science.gov (United States)

    Itsweire, E. C.; Holt, S. E.; Koseff, J. R.; Ferziger, J. H.

    1990-01-01

    Direct numerical simulations of the time evolution of homogeneous stably stratified turbulent shear flows have been performed for several Richardson numbers Ri and Reynolds numbers R(sub lambda) in earlier works. The results show excellent agreement with length scale models developed from laboratory experiments to characterize oceanic turbulence. When the Richardson number Ri is less than the stationary value Ri(sub s), the turbulence intensity grows at all scales, and the growth rate appears to be a function of Ri. The size of the vertical density inversions also increases. On the other hand, when Ri is greater than or equal to Ri(sub s) the largest turbulent eddies become vertically constrained by buoyancy when the Ellison (turbulence) scale L(sub E) and the Ozmidov (buoyancy) scale L(sub O) are equal. At this point, the mixing efficiency is maximal and corresponds to a flux Richardson number R(sub f) = 0.20. The vertical mass flux becomes counter-gradient when epsilon = 19(nu)N(exp 2) and vertical density overturns are suppressed in less than half a Brunt-Vaisala period. The results of the simulations were also recast in terms of the Hydrodynamic Phase Diagram introduced in fossil turbulence models. The so-called point of fossilization occurs when epsilon = 4DCN(exp 2); Gibson proposed 13DCN(exp 2). This value is in agreement with indirect laboratory observations and field observations. Finally, the validity of the steady-state models to estimate vertical eddy diffusivities in the oceanic thermocline is discussed.

  19. Inviscid incompressible limits of strongly stratified fluids

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard; Jin, B.J.; Novotný, A.

    2014-01-01

    Roč. 89, 3-4 (2014), s. 307-329 ISSN 0921-7134 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : compressible Navier-Stokes system * anelastic approximation * stratified fluid Subject RIV: BA - General Mathematics Impact factor: 0.528, year: 2014 http://iospress.metapress.com/content/d71255745tl50125/?p=969b60ae82634854ab8bd25505ce1f71&pi=3

  20. A Case Study of Offshore Advection of Boundary Layer Rolls over a Stably Stratified Sea Surface

    DEFF Research Database (Denmark)

    Svensson, Nina; Sahlée, Erik; Bergström, Hans

    2017-01-01

    originate from boundary layer rolls generated over the convective air above Swedish mainland, also supported by visual satellite images showing the typical signature cloud streets. The simulations indicate that the rolls are advected and maintained at least 30–80 km off the coast, in agreement...... with the streaks observed by the SAR images. During evening when the convective conditions over land diminish, the streaky structures over the sea are still seen in the horizontal wind field; however, the vertical component is close to zero. Thus advected feature from a land surface can affect the wind field...... considerably for long times and over large areas in coastal regions. Although boundary layer rolls are a well-studied feature, no previous study has presented results concerning their persistence during situations with advection to a strongly stratified boundary layer. Such conditions are commonly encountered...

  1. Observation of saltwater intrusion and ETM dynamics in a stably stratified estuary: the Yangtze Estuary, China.

    Science.gov (United States)

    Wan, Yuanyang; Zhao, Dezhao

    2017-02-01

    Spatial and temporal measurement data describing spring-neap variations of velocity, salinity, and suspended sediment concentration (SSC) in the North Passage Deepwater Navigational Channel (DNC) of the Yangtze Estuary, China, were obtained in the wet season of 2012. These data were collected in the middle of the DNC and apparently document the formation of a rather stable density stratification interface and salt wedge, especially during neap tides and slack waters. The convergent zone of residual currents, salinity transport, and sediment transport during neap and spring tides oscillates in the middle and lower reach of the DNC. It encourages the formation of a near-bed high-SSC layer, which favours siltation in the dredged channel. Both the near-bed gradient Richardson number and the bulk/layer Richardson number vary dramatically from around zero to several hundred from spring to neap tides. Stratification and turbulence damping effects near the estuarine turbidity maximum (ETM) area induce the upper half (near water surface) of the water body to be ebb-dominant and the lower part (near-bed) to be flood-dominant, which is a previously undocumented phenomenon in this region. These data reveal that the residual pattern of currents, salt flux and sediment flux are of critical differences in a stratified estuary, and that the salinity-induced baroclinic pressure gradient is a major factor controlling the vertical velocity structure. In addition, field observations indicate that the salinity and sediment transport of residuals generated by internal tidal asymmetry plays a dominant role in maintaining a stable density stratification interface near the estuarine front.

  2. Optimal bounds on the buoyancy flux in stably stratified Couette flow

    Science.gov (United States)

    Caulfield, C. P.; Tang, W.; Plasting, S. C.

    2003-11-01

    We calculate the best possible rigorous upper bound, subject to the assumption of streamwise invariance, on the long-time-averaged buoyancy flux within the flow of an incompressible viscous fluid between two infinite parallel plates, which are driven at different constant velocities, and maintained at different constant (stable) temperatures. We use the variational "background method", (due to Constantin, Doering, and Hopf) and numerical continuation to generate the best possible rigorous bounds at arbitrary Reynolds numbers, bulk Richardson numbers and Prandtl numbers. As Re arrow ∞, the upper bound on the buoyancy flux scales with the mechanical energy dissipation rate alone, with a scaling factor that we determine explicitly. Independently of the overall stratification, boundary layers are predicted to develop where the local gradient Richardson number becomes small, enabling significant mixing, with mixing efficiency for the bounding solutions that asymptotically approaches 1/3.

  3. Flow of two stratified fluids in an open channel with addition of fluids along the channel length

    International Nuclear Information System (INIS)

    Gardner, G.C.

    1980-01-01

    It is shown that two stably stratified fluids flowing in an open channel have two critical flow conditions. The one at higher flowrates is equivalent to the choked flow condition of a single fluid over a broad-crested weir, when the Froude number is unity. The lower critical condition imposes restrictions, which define the system if fluids are added progressively along the channel length and the flowrates increase from low to high values. However, if the flowrate does not become sufficiently large to pass through the lower critical condition, this condition will then define a form of choking, which again determines the system. It is shown that an important special case, with the proportional flowrates of the two fluids kept constant, has an analytical solution in which the relative depths of the fluids is a constant along the channel. Other systems must be solved numerically. (orig.)

  4. Application of compact finite-difference schemes to simulations of stably stratified fluid flows

    Czech Academy of Sciences Publication Activity Database

    Bodnár, Tomáš; Beneš, L.; Fraunie, P.; Kozel, Karel

    2012-01-01

    Roč. 219, č. 7 (2012), s. 3336-3353 ISSN 0096-3003 Institutional support: RVO:61388998 Keywords : stratification * finite-difference * finite-volume * Runge-Kutta Subject RIV: BA - General Mathematics Impact factor: 1.349, year: 2012 http://www.sciencedirect.com/science/article/pii/S0096300311010988

  5. Does a sheared flow stabilize inversely stratified fluid?

    DEFF Research Database (Denmark)

    Benilov, E.S.; Naulin, V.; Juul Rasmussen, J.

    2002-01-01

    with a monotonic profile (which were examined numerically). It turns out that virtually any deviation from the linear profiles examined by Kuo (1963) triggers off instability. This instability, however, is restricted either spectrally or spatially, which makes it different from the usual Rayleigh......-Taylor instability (in the absence of the flow, inversely stratified fluids are unstable at all points and all wavelengths). The conclusions of the paper are verified by simulation of the governing (nonlinear) equations. (C) 2002 American Institute of Physics....

  6. Calculation of periodic flows in a continuously stratified fluid

    Science.gov (United States)

    Vasiliev, A.

    2012-04-01

    Analytic theory of disturbances generated by an oscillating compact source in a viscous continuously stratified fluid was constructed. Exact solution of the internal waves generation problem was constructed taking into account diffusivity effects. This analysis is based on set of fundamental equations of incompressible flows. The linearized problem of periodic flows in a continuously stratified fluid, generated by an oscillating part of the inclined plane was solved by methods of singular perturbation theory. A rectangular or disc placed on a sloping plane and oscillating linearly in an arbitrary direction was selected as a source of disturbances. The solutions include regularly perturbed on dissipative component functions describing internal waves and a family of singularly perturbed functions. One of the functions from the singular components family has an analogue in a homogeneous fluid that is a periodic or Stokes' flow. Its thickness is defined by a universal micro scale depending on kinematics viscosity coefficient and a buoyancy frequency with a factor depending on the wave slope. Other singular perturbed functions are specific for stratified flows. Their thickness are defined the diffusion coefficient, kinematic viscosity and additional factor depending on geometry of the problem. Fields of fluid density, velocity, vorticity, pressure, energy density and flux as well as forces acting on the source are calculated for different types of the sources. It is shown that most effective source of waves is the bi-piston. Complete 3D problem is transformed in various limiting cases that are into 2D problem for source in stratified or homogeneous fluid and the Stokes problem for an oscillating infinite plane. The case of the "critical" angle that is equality of the emitting surface and the wave cone slope angles needs in separate investigations. In this case, the number of singular component is saved. Patterns of velocity and density fields were constructed and

  7. Plume Splitting in a Two-layer Stratified Ambient Fluid

    Science.gov (United States)

    Ma, Yongxing; Flynn, Morris; Sutherland, Bruce

    2017-11-01

    A line-source plume descending into a two-layer stratified ambient fluid in a finite sized tank is studied experimentally. Although the total volume of ambient fluid is fixed, lower- and upper-layer fluids are respectively removed and added at a constant rate mimicking marine outfall through diffusers and natural and hybrid ventilated buildings. The influence of the plume on the ambient depends on the value of λ, defined as the ratio of the plume buoyancy to the buoyancy loss of the plume as it crosses the ambient interface. Similar to classical filling-box experiments, the plume can always reach the bottom of the tank if λ > 1 . By contrast, if λ < 1 , an intermediate layer eventually forms as a result of plume splitting. Eventually all of the plume fluid spreads within the intermediate layer. The starting time, tv, and the ending time, tt, of the transition process measured from experiments correlate with the value of λ. A three-layer ambient fluid is observed after transition, and the mean value of the measured densities of the intermediate layer fluid is well predicted using plume theory. Acknowledgments: Funding for this study was provided by NSERC.

  8. Visualization periodic flows in a continuously stratified fluid.

    Science.gov (United States)

    Bardakov, R.; Vasiliev, A.

    2012-04-01

    To visualize the flow pattern of viscous continuously stratified fluid both experimental and computational methods were developed. Computational procedures were based on exact solutions of set of the fundamental equations. Solutions of the problems of flows producing by periodically oscillating disk (linear and torsion oscillations) were visualized with a high resolutions to distinguish small-scale the singular components on the background of strong internal waves. Numerical algorithm of visualization allows to represent both the scalar and vector fields, such as velocity, density, pressure, vorticity, stream function. The size of the source, buoyancy and oscillation frequency, kinematic viscosity of the medium effects were traced in 2D an 3D posing problems. Precision schlieren instrument was used to visualize the flow pattern produced by linear and torsion oscillations of strip and disk in a continuously stratified fluid. Uniform stratification was created by the continuous displacement method. The buoyancy period ranged from 7.5 to 14 s. In the experiments disks with diameters from 9 to 30 cm and a thickness of 1 mm to 10 mm were used. Different schlieren methods that are conventional vertical slit - Foucault knife, vertical slit - filament (Maksoutov's method) and horizontal slit - horizontal grating (natural "rainbow" schlieren method) help to produce supplementing flow patterns. Both internal wave beams and fine flow components were visualized in vicinity and far from the source. Intensity of high gradient envelopes increased proportionally the amplitude of the source. In domains of envelopes convergence isolated small scale vortices and extended mushroom like jets were formed. Experiments have shown that in the case of torsion oscillations pattern of currents is more complicated than in case of forced linear oscillations. Comparison with known theoretical model shows that nonlinear interactions between the regular and singular flow components must be taken

  9. A theoretical model of a wake of a body towed in a stratified fluid at large Reynolds and Froude numbers

    Directory of Open Access Journals (Sweden)

    Y. I. Troitskaya

    2006-01-01

    Full Text Available The objective of the present paper is to develop a theoretical model describing the evolution of a turbulent wake behind a towed sphere in a stably stratified fluid at large Froude and Reynolds numbers. The wake flow is considered as a quasi two-dimensional (2-D turbulent jet flow whose dynamics is governed by the momentum transfer from the mean flow to a quasi-2-D sinuous mode growing due to hydrodynamic instability. The model employs a quasi-linear approximation to describe this momentum transfer. The model scaling coefficients are defined with the use of available experimental data, and the performance of the model is verified by comparison with the results of a direct numerical simulation of a 2-D turbulent jet flow. The model prediction for the temporal development of the wake axis mean velocity is found to be in good agreement with the experimental data obtained by Spedding (1997.

  10. Dynamics of vortex structures in a stratified rotating fluid

    CERN Document Server

    Sokolovskiy, Mikhail A

    2013-01-01

    This book presents an extensive analysis of the dynamics of discrete and distributed baroclinic vortices in a multi-layer fluid that characterizes the main features of the large and mesoscales dynamics of the atmosphere and the ocean.

  11. Fluid mixing in stratified gravity currents: the Prandtl mixing length.

    Science.gov (United States)

    Odier, P; Chen, J; Rivera, M K; Ecke, R E

    2009-04-03

    Shear-induced vertical mixing in a stratified flow is a key ingredient of thermohaline circulation. We experimentally determine the vertical flux of momentum and density of a forced gravity current using high-resolution velocity and density measurements. A constant eddy-viscosity model provides a poor description of the physics of mixing, but a Prandtl mixing length model relating momentum and density fluxes to mean velocity and density gradients works well. For the average gradient Richardson number Ri(g) approximately 0.08 and a Taylor Reynolds number Re(lambda) approximately 100, the mixing lengths are fairly constant, about the same magnitude, comparable to the turbulent shear length.

  12. Internal wave patterns in enclosed density-stratified and rotating fluids

    NARCIS (Netherlands)

    Manders, A.M.A.

    2003-01-01

    Stratified fluids support internal waves, which propagate obliquely through the fluid. The angle with respectto the stratification direction is contrained: it is purely determined by the wave frequency and the strength of the density stratification (internal gravity waves) or the rotation rate

  13. Simulations of a porous particle settling in a density-stratified ambient fluid

    Science.gov (United States)

    Panah, Mac; Blanchette, François; Khatri, Shilpa

    2017-11-01

    We study numerically the settling of a porous sphere in a density-stratified ambient fluid. Simulations are validated against prior laboratory experiments and compared to two mathematical models. Two main effects cause the particle to slow down as it enters a density gradient: lighter fluid within the particle and entrainment of the density-stratified ambient fluid. The numerical simulations accurately capture the particle retention time. We quantify the delay in settling due to ambient fluid entrainment and lighter internal fluid becoming denser through diffusion as a function of the Reynolds, Péclet, and Darcy numbers, as well as the thickness of the transition layer and the ratio of the density difference between the lower and upper fluid layers to the density difference between the particle and the upper layer. A simple fitting formula is presented to describe the settling time delay as a function of each of those five nondimensional parameters.

  14. Exploring the role of wave drag in the stable stratified oceanic and atmospheric bottom boundary layer in the cnrs-toulouse (cnrm-game) large stratified water flume

    NARCIS (Netherlands)

    Kleczek, M.; Steeneveld, G.J.; Paci, A.; Calmer, R.; Belleudy, A.; Canonici, J.C.; Murguet, F.; Valette, V.

    2014-01-01

    This paper reports on a laboratory experiment in the CNRM-GAME (Toulouse) stratified water flume of a stably stratified boundary layer, in order to quantify the momentum transfer due to orographically induced gravity waves by gently undulating hills in a boundary layer flow. In a stratified fluid, a

  15. Spinning phenomena and energetics of spherically pulsating patterns in stratified fluids

    International Nuclear Information System (INIS)

    Ibragimov, Ranis N; Dameron, Michael

    2011-01-01

    The nonlinear solutions of the two-dimensional Boussinesq equations describing internal waves in rotating stratified fluids were obtained as group invariant solutions. The latter nonlinear solutions correspond to the rotation transformation preserving the form of the original nonlinear equations of motion. It is shown that the obtained class of exact solutions can be associated with the spherically pulsating patterns observed in uniformly stratified fluids. It is also shown that the obtained rotationally symmetric solutions are bounded functions that can be visualized as spinning patterns in stratified fluids. It is also shown that the rotational transformation provides the energy conservation law together with other conservation laws for which the spinning phenomena is observed. The effects of nonlinearity and the Earth's rotation on such a phenomenon are also discussed.

  16. Dynamic scaling and large scale effects in turbulence in compressible stratified fluid

    International Nuclear Information System (INIS)

    Pharasi, Hirdesh K.; Bhattacharjee, Jayanta K.

    2016-01-01

    We consider the propagation of sound in a turbulent fluid which is confined between two horizontal parallel plates, maintained at different temperatures. In the homogeneous fluid, Staroselsky et al. had predicted a divergent sound speed at large length scales. Here we find a divergent sound speed and a vanishing expansion coefficient at large length scales. Dispersion relation and the question of scale invariance at large distance scales lead to these results. - Highlights: • Turbulence in a stratified fluid has been studied in the Boussinesq approximation. • We extend this study to include density fluctuations due to pressure fluctuations. • For a homogeneous weakly compressible fluid the sound speed is known to become scale dependent. • For the stratified fluid we show that the expansion coefficient is also scale dependent. • Our results are based on general dynamic scaling arguments rather than detailed calculation.

  17. Simulation of plume rise: Study the effect of stably stratified turbulence layer on the rise of a buoyant plume from a continuous source by observing the plume centroid

    Science.gov (United States)

    Bhimireddy, Sudheer Reddy; Bhaganagar, Kiran

    2016-11-01

    Buoyant plumes are common in atmosphere when there exists a difference in temperature or density between the source and its ambience. In a stratified environment, plume rise happens until the buoyancy variation exists between the plume and ambience. In a calm no wind ambience, this plume rise is purely vertical and the entrainment happens because of the relative motion of the plume with ambience and also ambient turbulence. In this study, a plume centroid is defined as the plume mass center and is calculated from the kinematic equation which relates the rate of change of centroids position to the plume rise velocity. Parameters needed to describe the plume are considered as the plume radius, plumes vertical velocity and local buoyancy of the plume. The plume rise velocity is calculated by the mass, momentum and heat conservation equations in their differential form. Our study focuses on the entrainment velocity, as it depicts the extent of plume growth. This entrainment velocity is made up as sum of fractions of plume's relative velocity and ambient turbulence. From the results, we studied the effect of turbulence on the plume growth by observing the variation in the plume radius at different heights and the centroid height reached before loosing its buoyancy.

  18. Simulation of the instability in the stratified two-fluid system

    International Nuclear Information System (INIS)

    Cerne, G.; Tiselj, I.; Petelin, S.

    1999-01-01

    Two different models are combined together for the simulation of the Kelvin-Helmholtz instability in a channel. The disturbance on the interface of the initially stratified flow is amplifies and initiates dispersion of the fluids in the system. At the beginning sharp interface is needed to simulate the instability development therefore the VOF method was used. Later the two-fluid model is switched on in the domains where high dispersion of the fluids does not allow reliable use of the VOF method. The combined model enables the simulation of the whole two fluid phenomena.(author)

  19. The dynamics of small inertial particles in weakly stratified turbulence

    NARCIS (Netherlands)

    van Aartrijk, M.; Clercx, H.J.H.

    We present an overview of a numerical study on the small-scale dynamics and the large-scale dispersion of small inertial particles in stably stratified turbulence. Three types of particles are examined: fluid particles, light inertial particles (with particle-to-fluid density ratio 1Ͽp/Ͽf25) and

  20. Analysis of the dynamics of porous particles settling in a stratified fluid

    Science.gov (United States)

    Blanchette, Francois; Panah, Mac; Khatri, Shilpa

    2017-11-01

    We study the settling of a porous sphere in a density-stratified ambient fluid. Simulations are compared to two mathematical models. We quantify the delay in settling due to lighter fluid becoming denser through diffusion and that due to ambient fluid entrainment. We study the effects of the Reynolds, Péclet, and Darcy numbers, as well as the thickness of the transition layer, and the ratio of the density difference between the lower and upper fluid layer to the density difference between the particle and the upper layer. Dominant effects are identified and a simple fitting formula is presented to describe the settling time delay as a function of each of those five non-dimensional parameters.

  1. Energy Cascade from Internal Modes in Non-uniformly Stratified Fluid through Excitation of Superharmonic Disturbances

    Science.gov (United States)

    Sutherland, B. R.

    2016-02-01

    It is well established that two-dimensional internal plane waves and modes in uniformly stratified fluid efficiently transfer energy to smaller scale waves and ultimately turbulent mixing through parametric subharmonic instability (PSI). The numerical simulations of MacKinnon & Winters (GRL 2005) predicted PSI should act efficiently to disrupt the internal tide. However, while in situ observations showed the presence of PSI, it was not found to be appreciable. One reason for the discrepancy between simulations and observations is that the former examined an internal mode in uniformly stratified fluid whereas, in reality, the internal tide exists in non-uniform stratification and is manifest as sinusoidal oscillations of the thermocline. Through theory supported by numerical simulations, it is shown that internal modes in non-uniform stratification immediately excite superharmonics, not subharmonic disturbances. These have double the horizontal wavenumber and double the frequency of the parent mode and hence move with the same horizontal phase speed of the parent mode. As the disturbances grow in amplitude, however, they interact with the parent mode generating small-scale vertically propagating internal waves within the strongly stratified layer. The occurrence of PSI over very long times can occur, as in the simulations of Hazewinkel and Winters (JPO 2011). However, a comprehensive understanding of the energy cascade from the internal tide to small scales must consider the evolution of excited superharmonic disturbances.

  2. Computational Fluid Dynamics model of stratified atmospheric boundary-layer flow

    DEFF Research Database (Denmark)

    Koblitz, Tilman; Bechmann, Andreas; Sogachev, Andrey

    2015-01-01

    For wind resource assessment, the wind industry is increasingly relying on computational fluid dynamics models of the neutrally stratified surface-layer. So far, physical processes that are important to the whole atmospheric boundary-layer, such as the Coriolis effect, buoyancy forces and heat...... transport, are mostly ignored. In order to decrease the uncertainty of wind resource assessment, the present work focuses on atmospheric flows that include stability and Coriolis effects. The influence of these effects on the whole atmospheric boundary-layer are examined using a Reynolds-averaged Navier...

  3. Dispersion of (light) inertial particles in stratified turbulence

    NARCIS (Netherlands)

    van Aartrijk, M.; Clercx, H.J.H.; Armenio, Vincenzo; Geurts, Bernardus J.; Fröhlich, Jochen

    2010-01-01

    We present a brief overview of a numerical study of the dispersion of particles in stably stratified turbulence. Three types of particles arc examined: fluid particles, light inertial particles ($\\rho_p/\\rho_f = \\mathcal{O}(1)$) and heavy inertial particles ($\\rho_p/\\rho_f \\gg 1$). Stratification

  4. New numerical approaches for modeling thermochemical convection in a compositionally stratified fluid

    Science.gov (United States)

    Puckett, Elbridge Gerry; Turcotte, Donald L.; He, Ying; Lokavarapu, Harsha; Robey, Jonathan M.; Kellogg, Louise H.

    2018-03-01

    element code ASPECT, which we use to compute the velocity, pressure, and temperature associated with the underlying flow field. We compare the performance of these four algorithms on three problems, including computing an approximation to the solution of an initially compositionally stratified fluid at Ra =105 with buoyancy numbers B that vary from no stratification at B = 0 to stratified flow at large B .

  5. The stratified Boycott effect

    Science.gov (United States)

    Peacock, Tom; Blanchette, Francois; Bush, John W. M.

    2005-04-01

    We present the results of an experimental investigation of the flows generated by monodisperse particles settling at low Reynolds number in a stably stratified ambient with an inclined sidewall. In this configuration, upwelling beneath the inclined wall associated with the Boycott effect is opposed by the ambient density stratification. The evolution of the system is determined by the relative magnitudes of the container depth, h, and the neutral buoyancy height, hn = c0(ρp-ρf)/|dρ/dz|, where c0 is the particle concentration, ρp the particle density, ρf the mean fluid density and dρ/dz Boycott layer transports dense fluid from the bottom to the top of the system; subsequently, the upper clear layer of dense saline fluid is mixed by convection. For sufficiently strong stratification, h > hn, layering occurs. The lowermost layer is created by clear fluid transported from the base to its neutral buoyancy height, and has a vertical extent hn; subsequently, smaller overlying layers develop. Within each layer, convection erodes the initially linear density gradient, generating a step-like density profile throughout the system that persists after all the particles have settled. Particles are transported across the discrete density jumps between layers by plumes of particle-laden fluid.

  6. A review on rising bubble dynamics in viscosity-stratified fluids

    Indian Academy of Sciences (India)

    Kirti Chandra Sahu

    Systems with a bubble rising in a fluid, which has a variation of viscosity in space and time can be found in various natural phenomena and ... situations, due to the inherent presence of temperature variation and/or concentration gradient ... high contrasts in fluid properties, dynamically changing interface between the fluids, ...

  7. Two-phase pressurized thermal shock investigations using a 3D two-fluid modeling of stratified flow with condensation

    International Nuclear Information System (INIS)

    Yao, W.; Coste, P.; Bestion, D.; Boucker, M.

    2003-01-01

    In this paper, a local 3D two-fluid model for a turbulent stratified flow with/without condensation, which can be used to predict two-phase pressurized thermal shock, is presented. A modified turbulent K- model is proposed with turbulence production induced by interfacial friction. A model of interfacial friction based on a interfacial sublayer concept and three interfacial heat transfer models, namely, a model based on the small eddies controlled surface renewal concept (HDM, Hughes and Duffey, 1991), a model based on the asymptotic behavior of the Eddy Viscosity (EVM), and a model based on the Interfacial Sublayer concept (ISM) are implemented into a preliminary version of the NEPTUNE code based on the 3D module of the CATHARE code. As a first step to apply the above models to predict the two-phase thermal shock, the models are evaluated by comparison of calculated profiles with several experiments: a turbulent air-water stratified flow without interfacial heat transfer; a turbulent steam-water stratified flow with condensation; turbulence induced by the impact of a water jet in a water pool. The prediction results agree well with the experimental data. In addition, the comparison of three interfacial heat transfer models shows that EVM and ISM gave better prediction results while HDM highly overestimated the interfacial heat transfers compared to the experimental data of a steam water stratified flow

  8. The Fine Transverse Structure of a Vortex Flow Beyond the Edge of a Disc Rotating in a Stratified Fluid

    Science.gov (United States)

    Chashechkin, Yu. D.; Bardakov, R. N.

    2018-02-01

    By the methods of schlieren visualization, the evolution of elements of the fine structure of transverse vortex loops formed in the circular vortex behind the edge of a disk rotating in a continuously stratified fluid is traced for the first time. An inhomogeneous distribution of the density of a table-salt solution in a basin was formed by the continuous-squeezing method. The development of periodic perturbations at the outer boundary of the circular vortex and their transformation at the vortex-loop vertex are traced. A slow change in the angular size of the structural elements in the supercritical-flow mode is noted.

  9. A review on rising bubble dynamics in viscosity-stratified fluids

    Indian Academy of Sciences (India)

    Systems with a bubble rising in a fluid, which has a variation of viscosity in space and time can be found in various natural phenomena and industrial applications, including food processing, oil extraction, waste processing and biochemical reactors, to name a few. A review of the aspects studied in the literature on ...

  10. On singular limits arising in the scale analysis of stratified fluid flows

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard; Klein, R.; Novotný, A.; Zatorska, E.

    2016-01-01

    Roč. 26, č. 3 (2016), s. 419-443 ISSN 0218-2025 Grant - others:European Research Council(XE) MATHEF(320078) Institutional support: RVO:67985840 Keywords : isentropic fluid flow * strong stratification * singular limit * anelastic approximation Subject RIV: BA - General Mathematics Impact factor: 2.860, year: 2016 http://www.worldscientific.com/doi/10.1142/S021820251650007X

  11. Numerical investigation of thermally stratified Williamson fluid flow over a cylindrical surface via Keller box method

    Science.gov (United States)

    Bilal, S.; Rehman, Khalil Ur; Malik, M. Y.

    Present study is addressed to express the implementation of Keller-Box technique on physical problem in the field of fluid rheology, for this purpose the Williamson fluid flow is considered along a cylindrical stretching surface manifested with temperature stratification. The flow model is translated mathematically in terms of differential equations. Numerical simulation is executed to trace out the solution structure of developed differential system. The graphical outcomes for the flow regime of two different geometries (i-e cylindrical and plane surface) are reported and examined towards involved physical parameters. Furthermore, the local skin friction coefficient and local Nusselt number are computed numerically. A remarkable agreement of present study is noticed with the previously published results, which confirms the implementation and validation of Keller-Box scheme and it will serve as a helping source for the future correspondence.

  12. Dynamic simulation of wavy-stratified two-phase flow with the one-dimensional two-fluid model

    Science.gov (United States)

    Fullmer, William D.

    The one-dimensional two-fluid model is the basis for the description of the transport of mass, momentum and energy in the thermal-hydraulic codes used for nuclear reactor safety analysis. Unlike other physical transport models, the one-dimensional two-fluid model suffers from the possibility of being ill-posed as an initial-boundary value problem depending on the flow conditions and the relevant physical closure laws. Typically, the ill-posedness is dealt with through either excessive numerical damping or the addition of unphysical closure laws designed for the sole purpose of hyperbolization. Unfortunately both methods eliminate the instability along with the problem of ill-posedness causing the model to undoubtedly lose some of its inherent dynamic capability. In this work, a one-dimensional two-fluid model for horizontal or slightly inclined stratified flow is developed. Higher order physical models that are often neglected, such as surface tension and axial viscous stress, are retained for their short-wavelength stability properties. Characteristic, dispersion and nonlinear analyses are performed to demonstrate that the resulting model is linearly well-posed and nonlinearly well-behaved. While it has been known that higher-order differential terms are able to regularize the short-wavelength problem of ill-posedness without removing the long-wavelength instability, the literature is relatively silent on the consequences of using a model under linearly unstable conditions. Using carefully selected conditions in an idealized infinite domain, it is demonstrated for the first time that the one-dimensional two-fluid model exhibits chaotic behavior in addition to limit cycles and asymptotic stability. The chaotic behavior is a consequence of the long-wavelength linear instability (energy source) the nonlinearity (energy transfer) and the short-wavelength dissipation (energy sink). Since the model is chaotic, solutions exhibit a sensitive dependence on initial

  13. A computational fluid dynamics analysis on stratified scavenging system of medium capacity two-stroke internal combustion engines

    Directory of Open Access Journals (Sweden)

    Pitta Srinivasa Rao

    2008-01-01

    Full Text Available The main objective of the present work is to make a computational study of stratified scavenging system in two-stroke medium capacity engines to reduce or to curb the emissions from the two-stroke engines. The 3-D flows within the cylinder are simulated using computational fluid dynamics and the code Fluent 6. Flow structures in the transfer ports and the exhaust port are predicted without the stratification and with the stratification, and are well predicted. The total pressure and velocity map from computation provided comprehensive information on the scavenging and stratification phenomenon. Analysis is carried out for the transfer ports flow and the extra port in the transfer port along with the exhaust port when the piston is moving from the top dead center to the bottom dead center, as the ports are closed, half open, three forth open, and full port opening. An unstructured cell is adopted for meshing the geometry created in CATIA software. Flow is simulated by solving governing equations namely conservation of mass momentum and energy using SIMPLE algorithm. Turbulence is modeled by high Reynolds number version k-e model. Experimental measurements are made for validating the numerical prediction. Good agreement is observed between predicted result and experimental data; that the stratification had significantly reduced the emissions and fuel economy is achieved.

  14. Shape factors inclusion in a one‐dimensional, transient two‐fluid model for stratified and slug flow simulations in pipes

    OpenAIRE

    Bonzanini, Arianna; Picchi, Davide; Ferrari, Marco; Poesio, Pietro

    2017-01-01

    In previous works, (Ferrari et al., 2017) have shown that a onedimensional, hyperbolic, transient five equations two-fluid model is able to numerically describe stratified, wavy, and slug flow in horizontal and near-horizontal pipes. Slug statistical characteristics, such as slug velocity, frequency, and length can be numerically predicted with results in good agreement with experimental data and well-known empirical relations. In this model some approximated and simplified assumptions are ad...

  15. Environmental stratified flows

    CERN Document Server

    Armenio, Vincenzo

    2006-01-01

    The volume covers the theory of stratified flows, from basic concepts to recent developments in the area of environmental fluid mechanics. The state of art of numerical techniques suited for stratified flows is given. Results of very recent researches in the areas of environmental stratified flows are discussed with details. The topics are treated in four separate chapters. The volume gives a unified view of stratified turbulent flows, from small-scale mixing, to large-scale environmental phenomena, also including detailed discussion on interaction between turbulence and internal gravity waves. The book will serve as an important review tool for all the scientists involved in the investigation of small scale as well as geophysical stratified flows.

  16. Viscous Dissipation Effects on the Motion of Casson Fluid over an Upper Horizontal Thermally Stratified Melting Surface of a Paraboloid of Revolution: Boundary Layer Analysis

    Directory of Open Access Journals (Sweden)

    T. M. Ajayi

    2017-01-01

    Full Text Available The problem of a non-Newtonian fluid flow past an upper surface of an object that is neither a perfect horizontal/vertical nor inclined/cone in which dissipation of energy is associated with temperature-dependent plastic dynamic viscosity is considered. An attempt has been made to focus on the case of two-dimensional Casson fluid flow over a horizontal melting surface embedded in a thermally stratified medium. Since the viscosity of the non-Newtonian fluid tends to take energy from the motion (kinetic energy and transform it into internal energy, the viscous dissipation term is accommodated in the energy equation. Due to the existence of internal space-dependent heat source; plastic dynamic viscosity and thermal conductivity of the non-Newtonian fluid are assumed to vary linearly with temperature. Based on the boundary layer assumptions, suitable similarity variables are applied to nondimensionalized, parameterized and reduce the governing partial differential equations into a coupled ordinary differential equations. These equations along with the boundary conditions are solved numerically using the shooting method together with the Runge-Kutta technique. The effects of pertinent parameters are established. A significant increases in Rex1/2Cfx is guaranteed with St when magnitude of β is large. Rex1/2Cfx decreases with Ec and m.

  17. Numerical simulation of stratified flows from laboratory experiments to coastal ocean

    Science.gov (United States)

    Fraunie, Philippe

    2014-05-01

    Numeric modeling of a flow past vertical strip uniformly towing with permanent velocity in horizontal direction in a linearly stratified talk which was based on a finite differences solver adapted to the low Reynolds Navier-Stokes equation with transport equation for salinity (LES simulation [6]) has demonstrated reasonable agreement with data of schlieren visualization, density marker and probe measurements of internal wave fields. Another approach based on two different numerical methods for one specific case of stably stratified incompressible flow was developed, using the compact finite-difference discretizations. The numerical scheme itself follows the principle of semi-discretisation, with high order compact discretisation in space, while the time integration is carried out by the Strong Stability Preserving Runge-Kutta scheme. Results were compared against the reference solution obtained by the AUSM finite volume method [7]. The test case allowed demonstrating the ability of selected numerical methods to represent stably stratified flows over horizontal strip [4] and hill type 2D obstacles [1, 3] with generation of internal waves. From previous LES [4] and RANS [8] realistic simulations code, the ability of research codes to reproduce field observations is discussed. ACKNOWLEDGMENTS This research work was supported by Region Provence Alpes Côte d'Azur - Modtercom project, the Research Plan MSM 6840770010 of the Ministry of education of Czech Republic and the Russian Foundation for Basic Research (grant 12-01-00128). REFERENCES 1. Chashechkin Yu.D., Mitkin V.V. Experimental study of a fine structure of 2D wakes and mixing past an obstacle in a continuously stratified fluid // Dynamics of Atmosphere and Oceans. 2001. V. 34. P. 165-187. 2. Chashechkin, Yu. D. Hydrodynamics of a sphere in a stratified fluid // Fluid Dyn. 1989. V.24(1) P. 1-7. 3. Mitkin V. V., Chashechkin Yu. D. Transformation of hanging discontinuities into vortex systems in a stratified flow

  18. Turbulent gravitational convection from a point source in a non-uniformly stratified environment

    Science.gov (United States)

    Caulfield, C. P.; Woods, Andrew W.

    1998-04-01

    We examine the turbulent gravitational convection which develops above a point source of buoyant fluid in a stably stratified environment in which the buoyancy frequency varies with height according to N2=N2s (z/zs)[beta]. This generalizes the classical model of turbulent buoyant plumes rising through uniform and uniformly stratified environments originally developed by Morton et al. (1956). By analogy, the height of rise of a plume with initial buoyancy flux Fs has the form Hp= Ap[epsilon]p[minus sign]1/2Fs1/4Ns[minus sign]3/4hp ([lambda], [beta]) where [epsilon]p is the entrainment constant for plume motion, Ap is an O(1) constant, and the non-dimensional plume height, hp is a function of &[lambda]=Ap[epsilon]p[minus sign]1/2Fs1/4Ns[minus sign]3/4/zs and [beta].

  19. On the generation of magnetohydrodynamic waves in a stratified and magnetized fluid. II - Magnetohydrodynamic energy fluxes for late-type stars

    Science.gov (United States)

    Musielak, Z. E.; Rosner, R.

    1988-01-01

    Magnetohydrodynamic (MHD) wave energy fluxes for late-type stars are calculated, using previously obtained formulae for the source functions for the generation of MHD waves in a stratified, but otherwise uniform, turbulent atmosphere; the magnetic fields in the wave generation region are assumed to be homogeneous. In contradiction to previous results, it is shown that in this uniform magnetic field case there is no significant increase in the efficiency of MHD wave generation, at least within the theory's limits of applicability. The major results are that the MHD energy fluxes calculated for late-type stars are less than those obtained for compressible modes in the magnetic field-free case, and that these MHD energy fluxes do not vary enough for a given spectral type to explain the observed range of UV and X-ray fluxes from such stars. It is therefore concluded that MHD waves in stellar atmospheres with homogeneous magnetic fields in the wave generation region cannot explain the observed stellar coronal emissions; if such MHD waves are responsible for a significant component of stellar coronal heating, then nonuniform fields within the generation region must be appealed to.

  20. Longevity of Compositionally Stratified Layers in Ice Giants

    Science.gov (United States)

    Friedson, A. J.

    2017-12-01

    In the hydrogen-rich atmospheres of gas giants, a decrease with radius in the mixing ratio of a heavy species (e.g. He, CH4, H2O) has the potential to produce a density stratification that is convectively stable if the heavy species is sufficiently abundant. Formation of stable layers in the interiors of these planets has important implications for their internal structure, chemical mixing, dynamics, and thermal evolution, since vertical transport of heat and constituents in such layers is greatly reduced in comparison to that in convecting layers. Various processes have been suggested for creating compositionally stratified layers. In the interiors of Jupiter and Saturn, these include phase separation of He from metallic hydrogen and dissolution of dense core material into the surrounding metallic-H envelope. Condensation of methane and water has been proposed as a mechanism for producing stable zones in the atmospheres of Saturn and the ice giants. However, if a stably stratified layer is formed adjacent to an active region of convection, it may be susceptible to progressive erosion as the convection intrudes and entrains fluid into the unstable envelope. We discuss the principal factors that control the rate of entrainment and associated erosion and present a specific example concerning the longevity of stable layers formed by condensation of methane and water in Uranus and Neptune. We also consider whether the temporal variability of such layers may engender episodic behavior in the release of the internal heat of these planets. This research is supported by a grant from the NASA Solar System Workings Program.

  1. Strongly Stratified Turbulence Wakes and Mixing Produced by Fractal Wakes

    Science.gov (United States)

    Dimitrieva, Natalia; Redondo, Jose Manuel; Chashechkin, Yuli; Fraunie, Philippe; Velascos, David

    2017-04-01

    This paper describes Shliering and Shadowgraph experiments of the wake induced mixing produced by tranversing a vertical or horizontal fractal grid through the interfase between two miscible fluids at low Atwood and Reynolds numbers. This is a configuration design to models the mixing across isopycnals in stably-stratified flows in many environmental relevant situations (either in the atmosphere or in the ocean. The initial unstable stratification is characterized by a reduced gravity: g' = gΔρ ρ where g is gravity, Δρ being the initial density step and ρ the reference density. Here the Atwood number is A = g' _ 2 g . The topology of the fractal wake within the strong stratification, and the internal wave field produces both a turbulent cascade and a wave cascade, with frecuen parametric resonances, the envelope of the mixing front is found to follow a complex non steady 3rd order polinomial function with a maximum at about 4-5 Brunt-Vaisalla non-dimensional time scales: t/N δ = c1(t/N) + c2g Δρ ρ (t/N)2 -c3(t/N)3. Conductivity probes and Shliering and Shadowgraph visual techniques, including CIV with (Laser induced fluorescence and digitization of the light attenuation across the tank) are used in order to investigate the density gradients and the three-dimensionality of the expanding and contracting wake. Fractal analysis is also used in order to estimate the fastest and slowest growing wavelengths. The large scale structures are observed to increase in wave-length as the mixing progresses, and the processes involved in this increase in scale are also examined.Measurements of the pointwise and horizontally averaged concentrations confirm the picture obtained from past flow visualization studies. They show that the fluid passes through the mixing region with relatively small amounts of molecular mixing,and the molecular effects only dominate on longer time scales when the small scales have penetrated through the large scale structures. The Non

  2. Numerical analysis for MHD thermal and solutal stratified stagnation point flow of Powell-Eyring fluid induced by cylindrical surface with dual convection and heat generation effects

    Science.gov (United States)

    Khalil-Ur-Rehman; Malik, M. Y.; Bilal, S.; Bibi, M.

    The current analysis reports the untapped characteristics of magneto-hydrodynamic dual convection boundary layer stagnation point flow of Powell-Eyring fluid by way of cylindrical surface. Flow exploration is carried out with the combined effects of thermal and solutal stratification. The strength of temperature and concentration adjacent to the cylindrical surface is assumed to be greater than the ambient fluid. Flow conducting mathematically modelled equations are fairly transformed into system of coupled non-linear ordinary differential equations with the aid of suitable transformations. The computations are made against these resultant coupled equations through shooting technique by the support of fifth order Runge-Kutta algorithm. A parametric study is performed to examine the effect logs of various pertinent flow controlling parameters on the velocity, temperature and concentration flow regime. The achieved outcomes are validated by developing comparison with existing published literature. In addition, numerical values of skin friction coefficient and Nusselt number are presented graphically for two different geometries namely, plate and cylinder.

  3. Causal boundary for stably causal space-times

    International Nuclear Information System (INIS)

    Racz, I.

    1987-12-01

    The usual boundary constructions for space-times often yield an unsatisfactory boundary set. This problem is reviewed and a new solution is proposed. An explicit identification rule is given on the set of the ideal points of the space-time. This construction leads to a satisfactory boundary point set structure for stably causal space-times. The topological properties of the resulting causal boundary construction are examined. For the stably causal space-times each causal curve has a unique endpoint on the boundary set according to the extended Alexandrov topology. The extension of the space-time through the boundary is discussed. To describe the singularities the defined boundary sets have to be separated into two disjoint sets. (D.Gy.) 8 refs

  4. Effects of Corrugated Temperature Sheets on Optical Propagation along Quasi-Horizontal Paths in the Stably Stratified Atmosphere

    Science.gov (United States)

    2015-12-11

    5d.  PROJECT NUMBER 5e.  TASK NUMBER 5f.   WORK UNIT NUMBER 7.  PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) NORTHWEST RESEARCH ASSOCIATES INC...x) are statistically isotropic. It is well known, however, that n1(x) in the free atmosphere and in the nocturnal boundary layer is often strongly

  5. Laboratory investigations of the heat and momentum transfer in the stably stratified air turbulent boundary layer above the wavy surface

    Science.gov (United States)

    Sergeev, Daniil; Troitskaya, Yuliya; Vdovin, Maxim

    2015-04-01

    Investigation of small scale transfer processes between the ocean and atmosphere in the boundary and its parameterization on the meteorological conditions (wind and surface waves parameters) is very important for weather forecasts modeling [1]. The accuracy of the predictions taking in to account the so named bulk-formulas strongly depends on the quality empirical data. That is why the laboratory modeling sometimes is preferable (see [2]) then in situ measurements for obtaining enough ensembles of the data with a good accuracy in control conditions, first of all in a case of severe conditions (strong winds with intensive wave breaking and sprays generation). In this investigation laboratory modeling was performed on the Thermostratified Wind-Wave Channel of the IAP RAS (see. [3]). Experiments were carried out for the wind speeds up to 18.5 m/s (corresponding the equivalent 10-m wind speed 30 m/s). For the possibility of varying parameters of surface roughness independently on the wind flow a special system basing on the submerged mosquito mesh (cell of 2*2 mm) was used (see [4]). The roughness was controlled by the depth of the mesh installation under the free surface (no waves when the mesh was on the surface and maximum wave amplitude for the maximum depth). So, for each wind speed several cases of the waves parameters were investigated. During experiments a stable stratification of the boundary layer of air flow was obtained. Temperature of the heating air was 33-37 degrees (depending on the reference wind speed), and the water temperature was 14-16 degrees. The Pitote gauge and hotwire were used together for measuring velocity and temperature profiles. Also indirect estimations of the total volume of the phase of sprays were obtained by analyzing hotwire signals errors during droplets hits. Then aerodynamic drag CD and heat transfer Ch coefficients were obtained by profiling method. It was shown that that these parameters are very sensitive to the intensity of the spray of droplets generation, especially heat transfer. The work was supported by RFBR grants (14-05-91767, 14-08-31740, 15-35-20953) and RSF grant 14-17-00667 and by President grant for young scientists MK-3550.2014.5 References: 1. Emanuel, K. A. Sensitivity of tropical cyclones to surface exchange coefficients and a revised steady-state model incorporating eye dynamics // J. Atmos. Sci., 52(22), 3969-3976,1995. 2. Brian K. Haus, Dahai Jeong, Mark A. Donelan, Jun A. Zhang, and Ivan Savelyev Relative rates of sea-air heat transfer and frictional drag in very high winds // GEOPHYSICAL RESEARCH LETTERS, VOL. 37, L07802, doi:10.1029/2009GL042206, 2010 3. Yu. I. Troitskaya, D.A. Sergeev, A.A. Kandaurov, G.A Baidakov, M.A. Vdovin, V.I. Kazakov Laboratory and theoretical modeling of air-sea momentum transfer under severe wind conditions // JOURNAL OF GEOPHYSICAL RESEARCH, VOL. 117, C00J21, 13 PP., 2012 doi:10.1029/2011JC007778 4. Yu.I.Troitskaya, D.A.Sergeev, A.A.Kandaurov, M.I. Vdovin, A.A. Kandaurov, E.V.Ezhova, S.S.Zilitinkevich Momentum and buoyancy exchange in a turbulent air boundary layer over a wavy water surface. Part 2. Wind wave spectra // Nonlinear. Geoph. Processes, Vol. 20, P. 841-856, 2013.

  6. Mean shear flow in recirculating turbulent urban convection and the plume-puff eddy structure below stably stratified inversion layers

    Science.gov (United States)

    Fan, Yifan; Hunt, Julian; Yin, Shi; Li, Yuguo

    2018-03-01

    The mean and random components of the velocity field at very low wind speeds in a convective boundary layer (CBL) over a wide urban area are dominated by large eddy structures—either turbulent plumes or puffs. In the mixed layer at either side of the edges of urban areas, local mean recirculating flows are generated by sharp horizontal temperature gradients. These recirculation regions also control the mean shear profile and the bent-over plumes across the mixed layer, extending from the edge to the center of the urban area. A simplified physical model was proposed to calculate the mean flow speed at the edges of urban areas. Water tank experiments were carried out to study the mean recirculating flow and turbulent plume structures. The mean speed at urban edges was measured by the particle image velocimetry (PIV), and the plume structures were visualized by the thermalchromic liquid crystal (TLC) sheets. The horizontal velocity calculated by the physical model at the urban edge agrees well with that measured in the water tank experiments, with a root mean square of 0.03. The experiments also show that the pattern of the mean flow over the urban area changes significantly if the shape of the heated area changes or if the form of the heated urban area becomes sub-divided, for example by the creation of nearby but separated "satellite cities." The convective flow over the square urban area is characterized as the diagonal inflow at the lower level and the side outflow at the upper level. The outflow of the small city can be drawn into the inflow region of the large city in the "satellite city" case. A conceptual analysis shows how these changes significantly affect the patterns of dispersion of pollutants in different types of urban areas.

  7. Stratified vapor generator

    Science.gov (United States)

    Bharathan, Desikan [Lakewood, CO; Hassani, Vahab [Golden, CO

    2008-05-20

    A stratified vapor generator (110) comprises a first heating section (H.sub.1) and a second heating section (H.sub.2). The first and second heating sections (H.sub.1, H.sub.2) are arranged so that the inlet of the second heating section (H.sub.2) is operatively associated with the outlet of the first heating section (H.sub.1). A moisture separator (126) having a vapor outlet (164) and a liquid outlet (144) is operatively associated with the outlet (124) of the second heating section (H.sub.2). A cooling section (C.sub.1) is operatively associated with the liquid outlet (144) of the moisture separator (126) and includes an outlet that is operatively associated with the inlet of the second heating section (H.sub.2).

  8. Stably Expressed Genes Involved in Basic Cellular Functions.

    Directory of Open Access Journals (Sweden)

    Kejian Wang

    Full Text Available Stably Expressed Genes (SEGs whose expression varies within a narrow range may be involved in core cellular processes necessary for basic functions. To identify such genes, we re-analyzed existing RNA-Seq gene expression profiles across 11 organs at 4 developmental stages (from immature to old age in both sexes of F344 rats (n = 4/group; 320 samples. Expression changes (calculated as the maximum expression / minimum expression for each gene of >19000 genes across organs, ages, and sexes ranged from 2.35 to >109-fold, with a median of 165-fold. The expression of 278 SEGs was found to vary ≤4-fold and these genes were significantly involved in protein catabolism (proteasome and ubiquitination, RNA transport, protein processing, and the spliceosome. Such stability of expression was further validated in human samples where the expression variability of the homologous human SEGs was significantly lower than that of other genes in the human genome. It was also found that the homologous human SEGs were generally less subject to non-synonymous mutation than other genes, as would be expected of stably expressed genes. We also found that knockout of SEG homologs in mouse models was more likely to cause complete preweaning lethality than non-SEG homologs, corroborating the fundamental roles played by SEGs in biological development. Such stably expressed genes and pathways across life-stages suggest that tight control of these processes is important in basic cellular functions and that perturbation by endogenous (e.g., genetics or exogenous agents (e.g., drugs, environmental factors may cause serious adverse effects.

  9. From Near-Neutral to Strongly Stratified : Adequately Modelling the Clear-Sky Nocturnal Boundary Layer at Cabauw

    NARCIS (Netherlands)

    Baas, P.; van de Wiel, B.J.H.; van der Linden, S.J.A.; Bosveld, F. C.

    2017-01-01

    The performance of an atmospheric single-column model (SCM) is studied systematically for stably-stratified conditions. To this end, 11 years (2005–2015) of daily SCM simulations were compared to observations from the Cabauw observatory, The Netherlands. Each individual clear-sky night was

  10. THERMAL TIDES IN FLUID EXTRASOLAR PLANETS

    International Nuclear Information System (INIS)

    Arras, Phil; Socrates, Aristotle

    2010-01-01

    Asynchronous rotation and orbital eccentricity lead to time-dependent irradiation of the close-in gas giant exoplanets-the hot Jupiters. This time-dependent surface heating gives rise to fluid motions which propagate throughout the planet. We investigate the ability of this 'thermal tide' to produce a quadrupole moment which can couple to the stellar gravitational tidal force. While previous investigations discussed planets with solid surfaces, here we focus on entirely fluid planets in order to understand gas giants with small cores. The Coriolis force, thermal diffusion, and self-gravity of the perturbations are ignored for simplicity. First, we examine the response to thermal forcing through analytic solutions of the fluid equations which treat the forcing frequency as a small parameter. In the 'equilibrium tide' limit of zero frequency, fluid motion is present but does not induce a quadrupole moment. In the next approximation, finite frequency corrections to the equilibrium tide do lead to a nonzero quadrupole moment, the sign of which torques the planet away from synchronous spin. We then numerically solve the boundary value problem for the thermally forced, linear response of a planet with neutrally stratified interior and a stably stratified envelope. The numerical results find quadrupole moments in agreement with the analytic non-resonant result at a sufficiently long forcing period. Surprisingly, in the range of forcing periods of 1-30 days, the induced quadrupole moments can be far larger than the analytic result due to response of internal gravity waves which propagate in the radiative envelope. We discuss the relevance of our results for the spin, eccentricity, and thermal evolution of hot Jupiters.

  11. Stably Doped Conducting Polymer Nanoshells by Surface Initiated Polymerization.

    Science.gov (United States)

    Li, Junwei; Yoon, Soon Joon; Hsieh, Bao-Yu; Tai, Wanyi; O'Donnell, Matthew; Gao, Xiaohu

    2015-12-09

    Despite broad applications ranging from electronics to biomedical sensing and imaging, a long-standing problem of conducting polymers is the poor resistance to dedoping, which directly affects their signature electrical and optical properties. This problem is particularly significant for biomedical uses because of fast leaching of dopant ions in physiological environments. Here, we describe a new approach to engineer multimodal core-shell nanoparticles with a stably doped conductive polymer shell in biological environments. It was achieved by making a densely packed polymer brush rather than changing its molecular structure. Polyaniline (PANI) was used as a model compound due to its concentrated near-infrared (NIR) absorption. It was grafted onto a magnetic nanoparticle via a polydopamine intermediate layer. Remarkably, at pH 7 its conductivity is ca. 2000× higher than conventional PANI nanoshells. Similarly, its NIR absorption is enhanced by 2 orders of magnitude, ideal for photothermal imaging and therapy. Another surprising finding is its nonfouling property, even outperforming polyethylene glycol. This platform technology is also expected to open exciting opportunities in engineering stable conductive materials for electronics, imaging, and sensing.

  12. Mixing in a stratified shear flow: Energetics and sampling

    Science.gov (United States)

    Ivey, G. N.; Koseff, J. R.; Briggs, D. A.; Ferziger, J. H.

    1993-01-01

    Direct numerical simulations of the time evolution of homogeneous stably stratified shear flows have been performed for Richardson numbers from 0 to 1 and for Prandtl numbers between 0.1 and 2. The results indicate that mixing efficiency R(sub f) varies with turbulent Froude number in a manner consistent with laboratory experiments performed with Prandtl numbers of 0.7 and 700. However, unlike the laboratory results, for a particular Froude number, the simulations do not show a clear dependence on the magnitude of R(sub f) on Pr. The observed maximum value of R(sub f) is 0.25. When averaged over vertical length scales of an order of magnitude greater than either the overturning or Ozmidov scales of the flow, the simulations indicate that the dissipation rate epsilon is only weakly lognormally distributed with an intermittency of about 0.01 whereas estimated values in the ocean are 3 to 7.

  13. Persistent human cardiac Na+ currents in stably transfected mammalian cells

    Science.gov (United States)

    Wang, Ging Kuo; Russell, Gabriella; Wang, Sho-Ya

    2013-01-01

    Miniature persistent late Na+ currents in cardiomyocytes have been linked to arrhythmias and sudden death. The goals of this study are to establish a stable cell line expressing robust persistent cardiac Na+ currents and to test Class 1 antiarrhythmic drugs for selective action against resting and open states. After transient transfection of an inactivation-deficient human cardiac Na+ channel clone (hNav1.5-CW with L409C/A410W double mutations), transfected mammalian HEK293 cells were treated with 1 mg/ml G-418. Individual G-418-resistant colonies were isolated using glass cylinders. One colony with high expression of persistent Na+ currents was subjected to a second colony selection. Cells from this colony remained stable in expressing robust peak Na+ currents of 996 ± 173 pA/pF at +50 mV (n = 20). Persistent late Na+ currents in these cells were clearly visible during a 4-second depolarizing pulse albeit decayed slowly. This slow decay is likely due to slow inactivation of Na+ channels and could be largely eliminated by 5 μM batrachotoxin. Peak cardiac hNav1.5-CW Na+ currents were blocked by tetrodotoxin with an IC50 value of 2.27 ± 0.08 μM (n = 6). At clinic relevant concentrations, Class 1 antiarrhythmics are much more selective in blocking persistent late Na+ currents than their peak counterparts, with a selectivity ratio ranging from 80.6 (flecainide) to 3 (disopyramide). We conclude that (1) Class 1 antiarrhythmics differ widely in their resting- vs. open-channel selectivity, and (2) stably transfected HEK293 cells expressing large persistent hNav1.5-CW Na+ currents are suitable for studying as well as screening potent open-channel blockers. PMID:23695971

  14. Electromagnetic waves in stratified media

    CERN Document Server

    Wait, James R; Fock, V A; Wait, J R

    2013-01-01

    International Series of Monographs in Electromagnetic Waves, Volume 3: Electromagnetic Waves in Stratified Media provides information pertinent to the electromagnetic waves in media whose properties differ in one particular direction. This book discusses the important feature of the waves that enables communications at global distances. Organized into 13 chapters, this volume begins with an overview of the general analysis for the electromagnetic response of a plane stratified medium comprising of any number of parallel homogeneous layers. This text then explains the reflection of electromagne

  15. Turbulence Statistics of a Buoyant Jet in a Stratified Environment

    Science.gov (United States)

    McCleney, Amy Brooke

    Using non-intrusive optical diagnostics, turbulence statistics for a round, incompressible, buoyant, and vertical jet discharging freely into a stably linear stratified environment is studied and compared to a reference case of a neutrally buoyant jet in a uniform environment. This is part of a validation campaign for computational fluid dynamics (CFD). Buoyancy forces are known to significantly affect the jet evolution in a stratified environment. Despite their ubiquity in numerous natural and man-made flows, available data in these jets are limited, which constrain our understanding of the underlying physical processes. In particular, there is a dearth of velocity field data, which makes it challenging to validate numerical codes, currently used for modeling these important flows. Herein, jet near- and far-field behaviors are obtained with a combination of planar laser induced fluorescence (PLIF) and multi-scale time-resolved particle image velocimetry (TR-PIV) for Reynolds number up to 20,000. Deploying non-intrusive optical diagnostics in a variable density environment is challenging in liquids. The refractive index is strongly affected by the density, which introduces optical aberrations and occlusions that prevent the resolution of the flow. One solution consists of using index matched fluids with different densities. Here a pair of water solutions - isopropanol and NaCl - are identified that satisfy these requirements. In fact, they provide a density difference up to 5%, which is the largest reported for such fluid pairs. Additionally, by design, the kinematic viscosities of the solutions are identical. This greatly simplifies the analysis and subsequent simulations of the data. The spectral and temperature dependence of the solutions are fully characterized. In the near-field, shear layer roll-up is analyzed and characterized as a function of initial velocity profile. In the far-field, turbulence statistics are reported for two different scales, one

  16. The Stratified Legitimacy of Abortions.

    Science.gov (United States)

    Kimport, Katrina; Weitz, Tracy A; Freedman, Lori

    2016-12-01

    Roe v. Wade was heralded as an end to unequal access to abortion care in the United States. However, today, despite being common and safe, abortion is performed only selectively in hospitals and private practices. Drawing on 61 interviews with obstetrician-gynecologists in these settings, we examine how they determine which abortions to perform. We find that they distinguish between more and less legitimate abortions, producing a narrative of stratified legitimacy that privileges abortions for intended pregnancies, when the fetus is unhealthy, and when women perform normative gendered sexuality, including distress about the abortion, guilt about failure to contracept, and desire for motherhood. This stratified legitimacy can perpetuate socially-inflected inequality of access and normative gendered sexuality. Additionally, we argue that the practice by physicians of distinguishing among abortions can legitimate legislative practices that regulate and restrict some kinds of abortion, further constraining abortion access. © American Sociological Association 2016.

  17. Stratified Medicine and Reimbursement Issues

    Directory of Open Access Journals (Sweden)

    Hans-Joerg eFugel

    2012-10-01

    Full Text Available Stratified Medicine (SM has the potential to target patient populations who will most benefit from a therapy while reducing unnecessary health interventions associated with side effects. The link between clinical biomarkers/diagnostics and therapies provides new opportunities for value creation to strengthen the value proposition to pricing and reimbursement (P&R authorities. However, the introduction of SM challenges current reimbursement schemes in many EU countries and the US as different P&R policies have been adopted for drugs and diagnostics. Also, there is a lack of a consistent process for value assessment of more complex diagnostics in these markets. New, innovative approaches and more flexible P&R systems are needed to reflect the added value of diagnostic tests and to stimulate investments in new technologies. Yet, the framework for access of diagnostic–based therapies still requires further development while setting the right incentives and appropriate align stakeholders interests when realizing long- term patient benefits. This article addresses the reimbursement challenges of SM approaches in several EU countries and the US outlining some options to overcome existing reimbursement barriers for stratified medicine.

  18. Suppression of stratified explosive interactions

    Energy Technology Data Exchange (ETDEWEB)

    Meeks, M.K.; Shamoun, B.I.; Bonazza, R.; Corradini, M.L. [Wisconsin Univ., Madison, WI (United States). Dept. of Nuclear Engineering and Engineering Physics

    1998-01-01

    Stratified Fuel-Coolant Interaction (FCI) experiments with Refrigerant-134a and water were performed in a large-scale system. Air was uniformly injected into the coolant pool to establish a pre-existing void which could suppress the explosion. Two competing effects due to the variation of the air flow rate seem to influence the intensity of the explosion in this geometrical configuration. At low flow rates, although the injected air increases the void fraction, the concurrent agitation and mixing increases the intensity of the interaction. At higher flow rates, the increase in void fraction tends to attenuate the propagated pressure wave generated by the explosion. Experimental results show a complete suppression of the vapor explosion at high rates of air injection, corresponding to an average void fraction of larger than 30%. (author)

  19. Reynolds number dependence of an upper bound for the long-time-averaged buoyancy flux in plane stratified Couette flow

    Science.gov (United States)

    Caulfield, C. P.; Tang, W.; Plasting, S. C.

    2004-01-01

    We derive an improved rigorous upper bound for the long-time-averaged vertical buoyancy flux for stably stratified Couette flow; i.e. the flow of a Boussinesq fluid (with reference density rho_0, kinematic viscosity nu, and thermal diffusivity kappa) confined between two parallel horizontal plates separated by a distance d, which are driven at a constant relative velocity uDelta U, and are maintained at a constant (statically stable) temperature difference leading to a constant density difference uDelta rho. We construct the bound by means of a numerical solution to the ‘background method’ variation problem as formulated by Constantin and Doering using a one-dimensional uni-directional background. The upper bound so constructed is the best possible bound with the imposed constraints for streamwise independent mean flows that are statistically steady, and is calculated up to asymptotically large Reynolds numbers. We find that the associated (dimensional) upper bound {cal B}(*_{scriptsize) max} on the long-time-averaged and volume averaged buoyancy flux {cal B}(*:=lim_{t) -> infty} (1/t) int(t_0) g/rho_{0} dskew2tilde{t} (where u_3 is the vertical velocity, g is the acceleration due to gravity, and angled brackets denote volume averaging) does not depend on either the bulk Richardson number J=guDelta rho d/(rho_0 uDelta U(2)) of the flow, or the Prandtl number sigma=nu/kappa of the fluid. We show that {cal B}(*_{scriptsize) max} has the same inertial characteristic scaling as the (dimensional) mechanical energy dissipation rate {cal E}(*_B) , and {cal B}(*_{scriptsize) max}=0.001267uDelta U(3/d) as Re->infty. The associated flow structure exhibits velocity boundary layers embedded within density boundary layers, with local gradient Richardson numbers Ri =O(sigma/Re)≪ 1 in the vicinity of the horizontal plates. There is a correspondence between the predicted flow structure and the flow structure at a lower Reynolds number associated with the upper bound on the

  20. Modelling of vapour explosion in stratified geometrie

    International Nuclear Information System (INIS)

    Picchi, St.

    1999-01-01

    When a hot liquid comes into contact with a colder volatile liquid, one can obtain in some conditions an explosive vaporization, told vapour explosion, whose consequences can be important on neighbouring structures. This explosion needs the intimate mixing and the fine fragmentation between the two liquids. In a stratified vapour explosion, these two liquids are initially superposed and separated by a vapor film. A triggering of the explosion can induce a propagation of this along the film. A study of experimental results and existent models has allowed to retain the following main points: - the explosion propagation is due to a pressure wave propagating through the medium; - the mixing is due to the development of Kelvin-Helmholtz instabilities induced by the shear velocity between the two liquids behind the pressure wave. The presence of the vapour in the volatile liquid explains experimental propagation velocity and the velocity difference between the two fluids at the pressure wave crossing. A first model has been proposed by Brayer in 1994 in order to describe the fragmentation and the mixing of the two fluids. Results of the author do not show explosion propagation. We have therefore built a new mixing-fragmentation model based on the atomization phenomenon that develops itself during the pressure wave crossing. We have also taken into account the transient aspect of the heat transfer between fuel drops and the volatile liquid, and elaborated a model of transient heat transfer. These two models have been introduced in a multi-components, thermal, hydraulic code, MC3D. Results of calculation show a qualitative and quantitative agreement with experimental results and confirm basic options of the model. (author)

  1. Mathematical modeling of turbulent stratified flows. Application of liquid metal fast breeders

    International Nuclear Information System (INIS)

    Villand, M.; Grand, D.

    1983-01-01

    Mathematical model of turbulent stratified flow was proposed under the following assumptions: Newtonian fluid; incompressible fluid; coupling between temperature and momentum fields according to Boussinesq approximation; two-dimensional invariance for translation or rotation; coordinates cartesian or curvilinear. Solutions obtained by the proposed method are presented

  2. Spectral Analysis of Sound Propagation in Stratified Fluids.

    Science.gov (United States)

    1980-04-01

    solutions note that by (2.4) 81 Imq(±,) > 0 for E E R+(c(--)I) in t (5.43) Im q±(i, ) < 0 for EE R-(c(-o)I) in t and . y q + - ±iyq± ;y Im qi± iyRe q...f! h) (8.81) R3 (p,yX) tD (y,!pI X g(p,X)dXJ c-2 (y)p-1 (y)dpdy. Writing k(p,X) X ) g(p,X) E D(Qo) and applying Lemma 8.16 again gives .. ..J

  3. Stratified turbulence diagnostics for high-Reynolds-number momentum wakes

    Science.gov (United States)

    Diamessis, Peter; Zhou, Qi

    2017-11-01

    We analyze a large-eddy simulation (LES) dataset of the turbulent wake behind a sphere of diameter D translating at speed U in a linearly stratified Boussinesq fluid with buoyancy frequency N. These simulations are performed at Reynolds numbers Re ≡ UD / ν ∈ { 5 ×103 , 105 , 4 ×105 } and various Froude numbers Fr ≡ 2 U /(ND) . The recently obtained data at Re = 4 ×105 , the highest Re attained so far in either simulation or laboratory, and Fr ∈ { 4 , 16 } enable us to systematically investigate the effects of Reynolds number on this prototypical localized stratified turbulent shear flow. Our analysis focuses on the time evolution of various diagnostics of stratified turbulence, such as the horizontal and vertical integral length scales, turbulent kinetic energy and its dissipation rate ɛ, and the local rate of shear between the spontaneously formed layers of vorticity within the larger-scale quasi-horizontal flow structures. This leads to a discussion of the transitions between distinct stratified flow regimes (Brethouwer et al. 2007) in the appropriately defined phase diagram, and we highlight the dynamical role of the Gibson number Gi = ɛ /(νN2) , and its dependence on the body-based Reynolds number Re . ONR Grants N00014-13-1-0665 and N00014-15-1-2513.

  4. PHOTOSPHERIC EMISSION FROM STRATIFIED JETS

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Hirotaka; Nagataki, Shigehiro; Ono, Masaomi; Lee, Shiu-Hang; Mao, Jirong [Astrophysical Big Bang Laboratory, RIKEN, Saitama 351-0198 (Japan); Yamada, Shoichi [Department of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555 (Japan); Pe' er, Asaf [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Mizuta, Akira [KEK Theory Center, Tsukuba 305-0801 (Japan); Harikae, Seiji, E-mail: hito@yukawa.kyoto-u.ac.jp [Quants Research Department, Financial Engineering Division, Mitsubishi UFJ Morgan Stanley Securities Co., Ltd., Mejirodai Bldg., 3-29-20 Mejirodai, Bunkyo-ku, Tokyo 112-8688 (Japan)

    2013-11-01

    We explore photospheric emissions from stratified two-component jets, wherein a highly relativistic spine outflow is surrounded by a wider and less relativistic sheath outflow. Thermal photons are injected in regions of high optical depth and propagated until the photons escape at the photosphere. Because of the presence of shear in velocity (Lorentz factor) at the boundary of the spine and sheath region, a fraction of the injected photons are accelerated using a Fermi-like acceleration mechanism such that a high-energy power-law tail is formed in the resultant spectrum. We show, in particular, that if a velocity shear with a considerable variance in the bulk Lorentz factor is present, the high-energy part of observed gamma-ray bursts (GRBs) photon spectrum can be explained by this photon acceleration mechanism. We also show that the accelerated photons might also account for the origin of the extra-hard power-law component above the bump of the thermal-like peak seen in some peculiar bursts (e.g., GRB 090510, 090902B, 090926A). We demonstrate that time-integrated spectra can also reproduce the low-energy spectrum of GRBs consistently using a multi-temperature effect when time evolution of the outflow is considered. Last, we show that the empirical E{sub p}-L{sub p} relation can be explained by differences in the outflow properties of individual sources.

  5. Continuous Dependence on the Density for Stratified Steady Water Waves

    Science.gov (United States)

    Chen, Robin Ming; Walsh, Samuel

    2016-02-01

    There are two distinct regimes commonly used to model traveling waves in stratified water: continuous stratification, where the density is smooth throughout the fluid, and layer-wise continuous stratification, where the fluid consists of multiple immiscible strata. The former is the more physically accurate description, but the latter is frequently more amenable to analysis and computation. By the conservation of mass, the density is constant along the streamlines of the flow; the stratification can therefore be specified by prescribing the value of the density on each streamline. We call this the streamline density function. Our main result states that, for every smoothly stratified periodic traveling wave in a certain small-amplitude regime, there is an L ∞ neighborhood of its streamline density function such that, for any piecewise smooth streamline density function in that neighborhood, there is a corresponding traveling wave solution. Moreover, the mapping from streamline density function to wave is Lipschitz continuous in a certain function space framework. As this neighborhood includes piecewise smooth densities with arbitrarily many jump discontinues, this theorem provides a rigorous justification for the ubiquitous practice of approximating a smoothly stratified wave by a layered one. We also discuss some applications of this result to the study of the qualitative features of such waves.

  6. Analysis of stratified flow mixing

    International Nuclear Information System (INIS)

    Soo, S.L.; Lyczkowski, R.W.

    1985-01-01

    The Creare 1/5-scale Phase II experiments which model fluid and thermal mixing of relatively cold high pressure injection (HPI) water into a cold leg of a full-scale pressurized water reactor (PWR) having loop flow are analyzed and found that they cannot achieve complete similarity with respect to characteristic Reynolds and Froude numbers and developing hydrodynamic entry length. Several analyses show that these experiments fall into two distinct regimes of mixing: momentum controlled and gravity controlled (stratification). 18 refs., 9 figs

  7. A germline chromothripsis event stably segregating in 11 individuals through three generations

    DEFF Research Database (Denmark)

    Bertelsen, Birgitte; Nazaryan-Petersen, Lusine; Sun, Wei

    2016-01-01

    PURPOSE: Parentally transmitted germ-line chromothripsis (G-CTH) has been identified in only a few cases. Most of these rearrangements were stably transmitted, in an unbalanced form, from a healthy mother to her child with congenital abnormalities probably caused by de novo copy-number changes of...

  8. A review of recent developments on turbulent entrainment in stratified flows

    International Nuclear Information System (INIS)

    Cotel, Aline J

    2010-01-01

    Stratified interfaces are present in many geophysical flow situations, and transport across such an interface is an essential factor for correctly evaluating the physical processes taking place at many spatial and temporal scales in such flows. In order to accurately evaluate vertical and lateral transport occurring when a turbulent flow impinges on a stratified interface, the turbulent entrainment and vorticity generation mechanisms near the interface must be understood and quantified. Laboratory experiments were performed for three flow configurations: a vertical thermal, a sloping gravity current and a vertical turbulent jet with various tilt angles and precession speeds. All three flows impinged on an interface separating a two-layer stably stratified environment. The entrainment rate is quantified for each flow using laser-induced fluorescence and compared to predictions of Cotel and Breidenthal (1997 Appl. Sci. Res. 57 349-66). The possible applications of transport across stratified interfaces include the contribution of hydrothermal plumes to the global ocean energy budget, turbidity currents on the ocean floor, the design of lake de-stratification systems, modeling gas leaks from storage reservoirs, weather forecasting and global climate change.

  9. Instability and mixing in interacting stratified shear layers

    Science.gov (United States)

    Joe, W. T.; Caulfield, C. P.

    2003-11-01

    Often in geophysical fluid flows, a stratified shear flow undergoes a transition to turbulence, leading to markedly enhanced mixing of the fluid parcels, and deceleration of the forcing shear flow. Such mixing events generically lead to the development of a layered density distribution, with deep layers of relatively well-mixed fluid separated by relatively thin interfaces of strong density gradient. There are certain circumstances in which re-intensification of the shear by the external forcing is initially localized in the vicinity of the strong density gradient interfaces. We consider numerically the behaviour of a simple example of such flows, where a relatively deep well-mixed layer is bordered by two thin interfaces of stronger density gradient, each of which is subject to a localized velocity shear. We find that the stability and subsequent behaviour of such flows are qualitatively and quantitatively dependent on the overall stratification. Sufficiently strongly stratified flows lead to Kelvin-Helmholtz instabilities and associated mixing events which remain localized in the vicinity of the interfaces, while weaker stratification allows for intense interaction across the interior well-mixed layer.

  10. Colony polymerase chain reaction of stably transfected Trypanosoma cruzi grown on solid medium

    Directory of Open Access Journals (Sweden)

    Wagner G dos Santos

    2000-01-01

    Full Text Available Tools for the genetic manipulation of Trypanosoma cruzi are largely unavailable, although several vectors for transfection of epimastigotes and expression of foreign or recombinant genes have been developed. We have previously constructed several plasmid vectors in which recombinant genes are expressed in T. cruzi using the rRNA promoter. In this report, we demonstrate that one of these vectors can simultaneously mediate expression of neomycin phosphotransferase and green fluorescent protein when used to stably transfect cultured epimastigotes. These stably transfected epimastigotes can be selected and cloned as unique colonies on solid medium. We describe a simple colony PCR approach to the screening of these T. cruzi colonies for relevant genes. Thus, the methodologies outlined herein provide important new tools for the genetic dissection of this important parasite.

  11. Analytic and geometric study of stratified spaces

    CERN Document Server

    Pflaum, Markus J

    2001-01-01

    The book provides an introduction to stratification theory leading the reader up to modern research topics in the field. The first part presents the basics of stratification theory, in particular the Whitney conditions and Mather's control theory, and introduces the notion of a smooth structure. Moreover, it explains how one can use smooth structures to transfer differential geometric and analytic methods from the arena of manifolds to stratified spaces. In the second part the methods established in the first part are applied to particular classes of stratified spaces like for example orbit spaces. Then a new de Rham theory for stratified spaces is established and finally the Hochschild (co)homology theory of smooth functions on certain classes of stratified spaces is studied. The book should be accessible to readers acquainted with the basics of topology, analysis and differential geometry.

  12. Stratified growth in Pseudomonas aeruginosa biofilms

    DEFF Research Database (Denmark)

    Werner, E.; Roe, F.; Bugnicourt, A.

    2004-01-01

    In this study, stratified patterns of protein synthesis and growth were demonstrated in Pseudomonas aeruginosa biofilms. Spatial patterns of protein synthetic activity inside biofilms were characterized by the use of two green fluorescent protein (GFP) reporter gene constructs. One construct...

  13. Tidally-forced flow in a rotating, stratified, shoaling basin

    Science.gov (United States)

    Winters, Kraig B.

    2015-06-01

    Baroclinic flow of a rotating, stratified fluid in a parabolic basin is computed in response to barotropic tidal forcing using the nonlinear, non-hydrostatic, Boussinesq equations of motion. The tidal forcing is derived from an imposed, boundary-enhanced free-surface deflection that advances cyclonically around a central amphidrome. The tidal forcing perturbs a shallow pycnocline, sloshing it up and down over the shoaling bottom. Nonlinearities in the near-shore internal tide produce an azimuthally independent 'set-up' of the isopycnals that in turn drives an approximately geostrophically balanced, cyclonic, near-shore, sub-surface jet. The sub-surface cyclonic jet is an example of a slowly evolving, nearly balanced flow that is excited and maintained solely by forcing in the fast, super-inertial frequency band. Baroclinic instability of the nearly balanced jet and subsequent interactions between eddies produce a weak transfer of energy back into the inertia-gravity band as swirling motions with super-inertial vorticity stir the stratified fluid and spontaneously emit waves. The sub-surface cyclonic jet is similar in many ways to the poleward flows observed along eastern ocean boundaries, particularly the California Undercurrent. It is conjectured that such currents may be driven by the surface tide rather than by winds and/or along-shore pressure gradients.

  14. Direct contact condensation induced transition from stratified to slug flow

    International Nuclear Information System (INIS)

    Strubelj, Luka; Ezsoel, Gyoergy; Tiselj, Iztok

    2010-01-01

    Selected condensation-induced water hammer experiments performed on PMK-2 device were numerically modelled with three-dimensional two-fluid models of computer codes NEPTUNE C FD and CFX. Experimental setup consists of the horizontal pipe filled with the hot steam that is being slowly flooded with cold water. In most of the experimental cases, slow flooding of the pipe was abruptly interrupted by a strong slugging and water hammer, while in the selected experimental runs performed at higher initial pressures and temperatures that are analysed in the present work, the transition from the stratified into the slug flow was not accompanied by the water hammer pressure peak. That makes these cases more suitable tests for evaluation of the various condensation models in the horizontally stratified flows and puts them in the range of the available CFD (Computational Fluid Dynamics) codes. The key models for successful simulation appear to be the condensation model of the hot vapour on the cold liquid and the interfacial momentum transfer model. The surface renewal types of condensation correlations, developed for condensation in the stratified flows, were used in the simulations and were applied also in the regions of the slug flow. The 'large interface' model for inter-phase momentum transfer model was compared to the bubble drag model. The CFD simulations quantitatively captured the main phenomena of the experiments, while the stochastic nature of the particular condensation-induced water hammer experiments did not allow detailed prediction of the time and position of the slug formation in the pipe. We have clearly shown that even the selected experiments without water hammer present a tough test for the applied CFD codes, while modelling of the water hammer pressure peaks in two-phase flow, being a strongly compressible flow phenomena, is beyond the capability of the current CFD codes.

  15. Gas slug ascent through rheologically stratified conduits

    Science.gov (United States)

    Capponi, Antonio; James, Mike R.; Lane, Steve J.

    2016-04-01

    Textural and petrological evidence has indicated the presence of viscous, degassed magma layers at the top of the conduit at Stromboli. This layer acts as a plug through which gas slugs burst and it is thought to have a role in controlling the eruptive dynamics. Here, we present the results of laboratory experiments which detail the range of slug flow configurations that can develop in a rheologically stratified conduit. A gas slug can burst (1) after being fully accommodated within the plug volume, (2) whilst its base is still in the underlying low-viscosity liquid or (3) within a low-viscosity layer dynamically emplaced above the plug during the slug ascent. We illustrate the relevance of the same flow configurations at volcanic-scale through a new experimentally-validated 1D model and 3D computational fluid dynamic simulations. Applied to Stromboli, our results show that gas volume, plug thickness, plug viscosity and conduit radius control the transition between each configuration; in contrast, the configuration distribution seems insensitive to the viscosity of magma beneath the plug, which acts mainly to deliver the slug into the plug. Each identified flow configuration encompasses a variety of processes including dynamic narrowing and widening of the conduit, generation of instabilities along the falling liquid film, transient blockages of the slug path and slug break-up. All these complexities, in turn, lead to variations in the slug overpressure, mirrored by changes in infrasonic signatures which are also associated to different eruptive styles. Acoustic amplitudes are strongly dependent on the flow configuration in which the slugs burst, with both acoustic peak amplitudes and waveform shapes reflecting different burst dynamics. When compared to infrasonic signals from Stromboli, the similarity between real signals and laboratory waveforms suggests that the burst of a slug through a plug may represent a viable first-order mechanism for the generation of

  16. Bounds on stratified mixing with a mixing coefficient constraint

    Science.gov (United States)

    Tang, Wenbo; Caulfield, C. P.; Kerswell, Rich

    2005-11-01

    We derive non-trivial upper bounds for the long-time averaged vertical buoyancy flux B^* = ρu3>g/ρ0 for stably stratified Couette flow, with reference density ρ0, kinematic viscosity ν, thermal diffusivity κ, plate separation d, driven by constant relative velocity δU, maintained at a statically stable density difference δρ. We numerically solve the variational problem using the ``background method'', and require that the mean flow is streamwise independent and statistically steady. We impose a coupling constraint such that a fixed fraction γc of the energy input into the system leads to enhanced irreversible mixing. We calculate the bound up to asymptotically large Reynolds numbers for a range of choices of γc and bulk Richardson numbers J. For any Re, the calculated upper bound increases with J, until a maximum possible value J(Re,γc) at which the new constraint cannot be imposed, and the density field and velocity field become decoupled. The value of the bound at J is a non-monotonic function of γc, with γc=1/2 leading to the largest possible values as Re , consistently with the findings in Caulfield, Tang & Plasting (2004) where this coupling constraint was not imposed. In fact, at any particular Re, the previous solution may be associated with a specific value of γc. Imposing the coupling constraint with that γc, as J , the new bound approaches from below the previous bound exactly.

  17. Experimental investigation on isothermal stratified flow mixing in a horizontal T-junction

    Energy Technology Data Exchange (ETDEWEB)

    Isaev, Alexander; Kulenovic, Rudi; Laurien, Eckart [Stuttgart Univ. (Germany). Inst. fuer Kernenergetik und Energiesysteme (IKE)

    2016-10-15

    Turbulent and stratified flows can lead to thermal fatigue in piping systems of nuclear power plants (NPP). Such flows can be investigated in the University of Stuttgart Fluid-Structure-Interaction (FSI) facility with a T-Junction at thermal conditions with temperature differences of up to 255 K and at pressures of maximum 75 bars.

  18. Characterization of new cell line stably expressing CHI3L1 oncogene

    Directory of Open Access Journals (Sweden)

    Chekhonin V. P.

    2011-06-01

    Full Text Available Aim. To characterize the immortalized 293 cell line after stable transfection with human oncogene (CHI3L1. Methods. 293 cells, stably transfected with pcDNA3.1_CHI3L1, and 293 cells, stably transfected with pcDNA3.1 as a negative control, were used throughout all experiments. The clones of CHI3L1-expressing 293 cells and 293 cells, transfected with pcDNA3.1, were analyzed by immunofluorescence and confocal microscopy. Cell proliferation was measured using MTT assay; analyses of ERK1/2 and AKT activation and their cellular localization were performed with anti-phospho-ERK and anti-phospho-AKT antibodies. Specific activation of MAP and PI3 kinases was measured by densitometric analysis of Western-blot signals. Results. The obtained results show quite modest ability of CHI3L1 to stimulate cell growth and reflect rather an improved cellular plating efficiency of the 293 cells stably transfected with pcDNA3.1_CHI3L1 as compared to the 293 cells transfected with an «empty» vector. ERK1/2 and AKT are activated in the 293_CHI3L1 cells. In these cells phosphorylated ERK1/2 were localized in both cell cytoplasm and nuclei while AKT only in cytoplasm. The 293_CHI3L1 cells differed from the 293 cells, transfected with an «empty» vector, in their size and ability to adhere to the culture plates. Conclusions. The overexpression of CHI3L1 is likely to have an important role in tumorigenesis via a mechanism which involves activation of PI3K and ERK1/2 pathways. The tumors which can be induced by orthotopic implantation of the transformed human cells with overexpressed human oncogene CHI3L1 into the rat brain can be used as a target for anticancer drug development.

  19. Penetration of steady fluid motions into an outer stable layer excited by MHD thermal convection in rotating spherical shells

    Science.gov (United States)

    Takehiro, Shin-ichi; Sasaki, Youhei

    2018-03-01

    Penetration of steady magneto-hydrodynamic (MHD) disturbances into an upper strongly stratified stable layer excited by MHD thermal convection in rotating spherical shells is investigated. The theoretical model proposed by Takehiro (2015) is reexamined in the case of steady fluid motion below the bottom boundary. Steady disturbances penetrate into a density stratified MHD fluid existing in the semi-infinite region in the vertical direction. The axis of rotation of the system is tilted with respect to the vertical. The basic magnetic field is uniform and may be tilted with respect to the vertical and the rotation axis. Linear dispersion relation shows that the penetration distance with zero frequency depends on the amplitude of Alfvén wave speed. When Alfvén wave speed is small, viscous diffusion becomes dominant and penetration distance is similar to the horizontal scale of the disturbance at the lower boundary. In contrast, when Alfvén wave speed becomes larger, disturbance can penetrate deeper, and penetration distance becomes proportional to the Alfvén wave speed and inversely proportional to the geometric average of viscous and magnetic diffusion coefficients and to the total horizontal wavenumber. The analytic expression of penetration distance is in good agreement with the extent of penetration of mean zonal flow induced by finite amplitude convection in a rotating spherical shell with an upper stably stratified layer embedded in an axially uniform basic magnetic field. The theory expects that the stable layer suggested in the upper part of the outer core of the earth could be penetrated completely by mean zonal flows excited by thermal/compositional convection developing below the stable layer.

  20. Investigations of fabric stratifiers for solar tanks

    DEFF Research Database (Denmark)

    Andersen, Elsa; Furbo, Simon; Fan, Jianhua

    2005-01-01

    water. In this paper investigations of a number of different fabric stratification pipes are presented and compared to a non flexible inlet stratifier. Additional, detailed investigations of the flow structure close to two fabric stratification pipes are presented for one set of operating conditions...

  1. Direct multiangle solution for poorly stratified atmospheres

    Science.gov (United States)

    Vladimir Kovalev; Cyle Wold; Alexander Petkov; Wei Min Hao

    2012-01-01

    The direct multiangle solution is considered, which allows improving the scanning lidar-data-inversion accuracy when the requirement of the horizontally stratified atmosphere is poorly met. The signal measured at zenith or close to zenith is used as a core source for extracting optical characteristics of the atmospheric aerosol loading. The multiangle signals are used...

  2. Nonlinear evolution of a layered stratified shear flow

    Science.gov (United States)

    Lee, V.; Caulfield, C. P.

    2001-10-01

    We investigate numerically and theoretically the nonlinear evolution of a parallel shear flow at moderate Reynolds number which has embedded within it a mixed layer of intermediate fluid. The two relatively thin strongly stratified density interfaces are centered on the edges of the shear layer. We are particularly interested in the development of primary and secondary instabilities. We present the results of a stability analysis which predicts that such flows may be unstable to stationary vortical disturbances which are a generalization of an inviscid instability first considered by G.I. Taylor. We investigate the behavior of these "Taylor billows" at finite amplitude through two-dimensional numerical simulations. We observe that the braid regions connecting adjacent primary Taylor billows are susceptible to secondary, inherently two-dimensional instabilities. We verify that these secondary instabilities, which take the form of small elliptical vortices, arise due to a local intensification of the spanwise vorticity in the braid region.

  3. HeLa-LAV, an epithelial cell line stably infected with HIV-1.

    Science.gov (United States)

    Berg, J; Doe, B; Steimer, K S; Wabl, M

    1991-01-01

    An HeLa-LAV cell line was established by infecting and subcloning previously described CD4-expressing HeLa cells with HIV-1. Cells of this line stably synthesize all major HIV proteins, release infectious particles of HIV-1, but do not die even after long term culture. More than 90% of the cells express the envelope protein gp120 on the surface. The cells can be easily and efficiently labeled with 51chromium, and exhibit a low spontaneous release. Because they are susceptible to killing by allogeneic cytotoxic T cells (CTL) when targeted to gp120, they ought to be a useful source of target cells in any kind of HIV-specific killing assays. The cells may also help studies on HIV replication in non-lymphatic/non-monocytic cells. The HeLa-LAV cell line will be freely available from the AIDS Research and Reference Reagent Program.

  4. MC3D modelling of stratified explosion

    International Nuclear Information System (INIS)

    Picchi, S.; Berthoud, G.

    1999-01-01

    It is known that a steam explosion can occur in a stratified geometry and that the observed yields are lower than in the case of explosion in a premixture configuration. However, very few models are available to quantify the amount of melt which can be involved and the pressure peak that can be developed. In the stratified application of the MC3D code, mixing and fragmentation of the melt are explained by the growth of Kelvin Helmholtz instabilities due to the shear flow of the two phase coolant above the melt. Such a model is then used to recalculate the Frost-Ciccarelli tin-water experiment. Pressure peak, speed of propagation, bubble shape and erosion height are well reproduced as well as the influence of the inertial constraint (height of the water pool). (author)

  5. Nitrogen transformations in stratified aquatic microbial ecosystems

    DEFF Research Database (Denmark)

    Revsbech, Niels Peter; Risgaard-Petersen, N.; Schramm, Andreas

    2006-01-01

    Abstract  New analytical methods such as advanced molecular techniques and microsensors have resulted in new insights about how nitrogen transformations in stratified microbial systems such as sediments and biofilms are regulated at a µm-mm scale. A large and ever-expanding knowledge base about n...... performing dissimilatory reduction of nitrate to ammonium have given new dimensions to the understanding of nitrogen cycling in nature, and the occurrence of these organisms and processes in stratified microbial communities will be described in detail.......Abstract  New analytical methods such as advanced molecular techniques and microsensors have resulted in new insights about how nitrogen transformations in stratified microbial systems such as sediments and biofilms are regulated at a µm-mm scale. A large and ever-expanding knowledge base about...... nitrogen fixation, nitrification, denitrification, and dissimilatory reduction of nitrate to ammonium, and about the microorganisms performing the processes, has been produced by use of these techniques. During the last decade the discovery of anammmox bacteria and migrating, nitrate accumulating bacteria...

  6. From Near-Neutral to Strongly Stratified: Adequately Modelling the Clear-Sky Nocturnal Boundary Layer at Cabauw

    Science.gov (United States)

    Baas, P.; van de Wiel, B. J. H.; van der Linden, S. J. A.; Bosveld, F. C.

    2018-02-01

    The performance of an atmospheric single-column model (SCM) is studied systematically for stably-stratified conditions. To this end, 11 years (2005-2015) of daily SCM simulations were compared to observations from the Cabauw observatory, The Netherlands. Each individual clear-sky night was classified in terms of the ambient geostrophic wind speed with a 1 m s^{-1} bin-width. Nights with overcast conditions were filtered out by selecting only those nights with an average net radiation of less than - 30 W m^{-2}. A similar procedure was applied to the observational dataset. A comparison of observed and modelled ensemble-averaged profiles of wind speed and potential temperature and time series of turbulent fluxes showed that the model represents the dynamics of the nocturnal boundary layer (NBL) at Cabauw very well for a broad range of mechanical forcing conditions. No obvious difference in model performance was found between near-neutral and strongly-stratified conditions. Furthermore, observed NBL regime transitions are represented in a natural way. The reference model version performs much better than a model version that applies excessive vertical mixing as is done in several (global) operational models. Model sensitivity runs showed that for weak-wind conditions the inversion strength depends much more on details of the land-atmosphere coupling than on the turbulent mixing. The presented results indicate that in principle the physical parametrizations of large-scale atmospheric models are sufficiently equipped for modelling stably-stratified conditions for a wide range of forcing conditions.

  7. A criterion for the onset of slugging in horizontal stratified air-water countercurrent flow

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Moon-Hyun; Lee, Byung-Ryung; Kim, Yang-Seok [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)] [and others

    1995-09-01

    This paper presents an experimental and theoretical investigation of wave height and transition criterion from wavy to slug flow in horizontal air-water countercurrent stratified flow conditions. A theoretical formula for the wave height in a stratified wavy flow regime has been developed using the concept of total energy balance over a wave crest to consider the shear stress acting on the interface of two fluids. From the limiting condition of the formula for the wave height, a necessary criterion for transition from a stratified wavy flow to a slug flow has been derived. A series of experiments have been conducted changing the non-dimensional water depth and the flow rates of air in a horizontal pipe and a duct. Comparisons between the measured data and the predictions of the present theory show that the agreement is within {plus_minus}8%.

  8. A criterion for the onset of slugging in horizontal stratified air-water countercurrent flow

    International Nuclear Information System (INIS)

    Chun, Moon-Hyun; Lee, Byung-Ryung; Kim, Yang-Seok

    1995-01-01

    This paper presents an experimental and theoretical investigation of wave height and transition criterion from wavy to slug flow in horizontal air-water countercurrent stratified flow conditions. A theoretical formula for the wave height in a stratified wavy flow regime has been developed using the concept of total energy balance over a wave crest to consider the shear stress acting on the interface of two fluids. From the limiting condition of the formula for the wave height, a necessary criterion for transition from a stratified wavy flow to a slug flow has been derived. A series of experiments have been conducted changing the non-dimensional water depth and the flow rates of air in a horizontal pipe and a duct. Comparisons between the measured data and the predictions of the present theory show that the agreement is within ±8%

  9. Stratified Coastal Trapped Waves and Mean Flows

    National Research Council Canada - National Science Library

    Thompson, LuAnne

    1998-01-01

    Our long term goals are to identify the roles that rectified subinertial waves and mesoscale motions play in the mean-flow transport of fluid properties in the coastal ocean and to apply these ideas...

  10. [Causes of emergency dizziness stratified by etiology].

    Science.gov (United States)

    Qiao, Wenying; Liu, Jianguo; Zeng, Hong; Liu, Yugeng; Jia, Weihua; Wang, Honghong; Liu, Bo; Tan, Jing; Li, Changqing

    2014-06-03

    To explore the causes of emergency dizziness stratified to improve the diagnostic efficiency. A total of 1 857 cases of dizziness at our emergency department were collected and their etiologies stratified by age and gender. The top three diagnoses were benign paroxysmal positional vertigo (BPPV, 31.7%), hypertension (24.0%) and posterior circulation ischemia (PCI, 20.5%). Stratified by age, the main causes of dizziness included BPPV (n = 6), migraine-associated vertigo (n = 2), unknown cause (n = 1) for the group of vertigo (14.5%) and neurosis (7.3%) for 18-44 years; BPPV (36.8%), hypertension (22.4%) and migraine-associated vertigo (11.2%) for 45-59 years; hypertension (30.8%), PCI (29.8%) and BPPV (22.9%) for 60-74 years; PCI (30.7%), hypertension (28.6%) and BPPV (25.5%) for 75-92 years. BPPV, migraine and neurosis were more common in females while hypertension and PCI predominated in males (all P hypertension, neurosis and migraine showed the following significant demographic features: BPPV, PCI, hypertension, neurosis and migraine may be the main causes of dizziness. BPPV should be considered initially when vertigo was triggered repeatedly by positional change, especially for young and middle-aged women. And the other common causes of dizziness were migraine-associated vertigo, neurosis and Meniere's disease.Hypertension should be screened firstly in middle-aged and elderly patients presenting mainly with head heaviness and stretching. In elders with dizziness, BPPV is second in constituent ratio to PCI and hypertension.In middle-aged and elderly patients with dizziness, psychological factors should be considered and diagnosis and treatment should be offered timely.

  11. Bayesian stratified sampling to assess corpus utility

    Energy Technology Data Exchange (ETDEWEB)

    Hochberg, J.; Scovel, C.; Thomas, T.; Hall, S.

    1998-12-01

    This paper describes a method for asking statistical questions about a large text corpus. The authors exemplify the method by addressing the question, ``What percentage of Federal Register documents are real documents, of possible interest to a text researcher or analyst?`` They estimate an answer to this question by evaluating 200 documents selected from a corpus of 45,820 Federal Register documents. Bayesian analysis and stratified sampling are used to reduce the sampling uncertainty of the estimate from over 3,100 documents to fewer than 1,000. A possible application of the method is to establish baseline statistics used to estimate recall rates for information retrieval systems.

  12. Investigations on flow reversal in stratified horizontal flow

    International Nuclear Information System (INIS)

    Staebler, T.; Meyer, L.; Schulenberg, T.; Laurien, E.

    2005-01-01

    The phenomena of flow reversal in stratified flows are investigated in a horizontal channel with application to the Emergency Core Cooling System (ECCS) in Pressurized Water Reactors (PWR). In case of a Loss-of-Coolant-Accident (LOCA), coolant can be injected through a secondary pipe within the feeding line of the primary circuit, the so called hot leg, counter-currently to the steam flow. It is essential that the coolant reaches the reactor core to prevent overheating. Due to high temperatures in such accident scenarios, steam is generated in the core, which escapes from the reactor vessel through the hot leg. In case of sufficiently high steam flow rates, only a reduced amount of coolant or even no coolant will be delivered to the reactor core. The WENKA test facility at the Institute for Nuclear and Energy Technologies (IKET) at Forschungszentrum Karlsruhe is capable to investigate the fluid dynamics of two-phase flows in such scenarios. Water and air flow counter-currently in a horizontal channel made of clear acrylic glass to allow full optical access. Flow rates of water and air can be varied independently within a wide range. Once flow reversal sets in, a strong hysteresis effect must be taken into account. This was quantified during the present investigations. Local experimental data are needed to expand appropriate models on flow reversal in horizontal two-phase flow and to include them into numerical codes. Investigations are carried out by means of Particle Image Velocimetry (PIV) to obtain local flow velocities without disturbing the flow. Due to the wavy character of the flow, strong reflections at the interfacial area must be taken into account. Using fluorescent particles and an optical filter allows eliminating the reflections and recording only the signals of the particles. The challenges in conducting local investigations in stratified wavy flows by applying optical measurement techniques are discussed. Results are presented and discussed allowing

  13. Silicon homo-heterojunction solar cells: A promising candidate to realize high performance more stably

    Science.gov (United States)

    Tan, Miao; Zhong, Sihua; Wang, Wenjie; Shen, Wenzhong

    2017-08-01

    We have investigated the influences of diverse physical parameters on the performances of a silicon homo-heterojunction (H-H) solar cell, which encompasses both homojunction and heterojunction, together with their underlying mechanisms by the aid of AFORS-HET simulation. It is found that the performances of H-H solar cell are less sensitive to (i) the work function of the transparent conductive oxide layer, (ii) the interfacial density of states at the front hydrogenated amorphous silicon/crystalline silicon (a-Si:H/c-Si) interface, (iii) the peak dangling bond defect densities within the p-type a-Si:H (p-a-Si:H) layer, and (iv) the doping concentration of the p-a-Si:H layer, when compared to that of the conventional heterojunction with intrinsic thin layer (HIT) counterparts. These advantages are due to the fact that the interfacial recombination and the recombination within the a-Si:H region are less affected by all the above parameters, which fundamentally benefit from the field-effect passivation of the homojunction. Therefore, the design of H-H structure can provide an opportunity to produce high-efficiency solar cells more stably.

  14. Silicon homo-heterojunction solar cells: A promising candidate to realize high performance more stably

    Directory of Open Access Journals (Sweden)

    Miao Tan

    2017-08-01

    Full Text Available We have investigated the influences of diverse physical parameters on the performances of a silicon homo-heterojunction (H-H solar cell, which encompasses both homojunction and heterojunction, together with their underlying mechanisms by the aid of AFORS-HET simulation. It is found that the performances of H-H solar cell are less sensitive to (i the work function of the transparent conductive oxide layer, (ii the interfacial density of states at the front hydrogenated amorphous silicon/crystalline silicon (a-Si:H/c-Si interface, (iii the peak dangling bond defect densities within the p-type a-Si:H (p-a-Si:H layer, and (iv the doping concentration of the p-a-Si:H layer, when compared to that of the conventional heterojunction with intrinsic thin layer (HIT counterparts. These advantages are due to the fact that the interfacial recombination and the recombination within the a-Si:H region are less affected by all the above parameters, which fundamentally benefit from the field-effect passivation of the homojunction. Therefore, the design of H-H structure can provide an opportunity to produce high-efficiency solar cells more stably.

  15. Experimental determination and modelling of interface area concentration in horizontal stratified flow

    International Nuclear Information System (INIS)

    Junqua-Moullet, Alexandra

    2003-01-01

    This research thesis concerns the modelling and experimentation of biphasic liquid/gas flows (water/air) while using the two-fluid model, a six-equation model. The author first addresses the modelling of interfacial magnitudes for a known topology (problem of two-fluid model closure, closure relationships for some variables, equation for a given configuration). She reports the development of an equation system for interfacial magnitudes. The next parts deal with experiments and report the study of stratified flows in the THALC experiment, and more particularly the study of the interfacial area concentration and of the liquid velocities in such flows. Results are discussed, as well as their consistency

  16. Thermal instability in a stratified plasma

    International Nuclear Information System (INIS)

    Hermanns, D.F.M.; Priest, E.R.

    1989-01-01

    The thermal instability mechansism has been studied in connection to observed coronal features, like, e.g. prominences or cool cores in loops. Although these features show a lot of structure, most studies concern the thermal instability in an uniform medium. In this paper, we investigate the thermal instability and the interaction between thermal modes and the slow magneto-acoustic subspectrum for a stratified plasma slab. We fomulate the relevant system of equations and give some straightforward properties of the linear spectrum of a non-uniform plasma slab, i.e. the existence of continuous parts in the spectrum. We present a numerical scheme with which we can investigate the linear spectrum for equilibrium states with stratification. The slow and thermal subspectra of a crude coronal model are given as a preliminary result. (author). 6 refs.; 1 fig

  17. Ecosystem metabolism in a stratified lake

    DEFF Research Database (Denmark)

    Stæhr, Peter A.; Christensen, Jesper P. A.; Batt, Ryan D.

    2012-01-01

    that integrates rates across the entire depth profile and includes DO exchange between depth layers driven by mixed-layer deepening and eddy diffusivity. During full mixing, NEP was close to zero throughout the water column, and GPP and R were reduced 2-10 times compared to stratified periods. When present....... Although air-water gas exchange rates differed among the three formulations of gas-transfer velocity, this had no significant effect on metabolic rates.......Seasonal changes in rates of gross primary production (GPP), net ecosystem production (NEP), and respiration (R) were determined from frequent automated profiles of dissolved oxygen (DO) and temperature in a clear-water polymictic lake. Metabolic rate calculations were made using a method...

  18. Stratified scaffold design for engineering composite tissues.

    Science.gov (United States)

    Mosher, Christopher Z; Spalazzi, Jeffrey P; Lu, Helen H

    2015-08-01

    A significant challenge to orthopaedic soft tissue repair is the biological fixation of autologous or allogeneic grafts with bone, whereby the lack of functional integration between such grafts and host bone has limited the clinical success of anterior cruciate ligament (ACL) and other common soft tissue-based reconstructive grafts. The inability of current surgical reconstruction to restore the native fibrocartilaginous insertion between the ACL and the femur or tibia, which minimizes stress concentration and facilitates load transfer between the soft and hard tissues, compromises the long-term clinical functionality of these grafts. To enable integration, a stratified scaffold design that mimics the multiple tissue regions of the ACL interface (ligament-fibrocartilage-bone) represents a promising strategy for composite tissue formation. Moreover, distinct cellular organization and phase-specific matrix heterogeneity achieved through co- or tri-culture within the scaffold system can promote biomimetic multi-tissue regeneration. Here, we describe the methods for fabricating a tri-phasic scaffold intended for ligament-bone integration, as well as the tri-culture of fibroblasts, chondrocytes, and osteoblasts on the stratified scaffold for the formation of structurally contiguous and compositionally distinct regions of ligament, fibrocartilage and bone. The primary advantage of the tri-phasic scaffold is the recapitulation of the multi-tissue organization across the native interface through the layered design. Moreover, in addition to ease of fabrication, each scaffold phase is similar in polymer composition and therefore can be joined together by sintering, enabling the seamless integration of each region and avoiding delamination between scaffold layers. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.

    Science.gov (United States)

    Tailor, Jignesh; Kittappa, Raja; Leto, Ketty; Gates, Monte; Borel, Melodie; Paulsen, Ole; Spitzer, Sonia; Karadottir, Ragnhildur Thora; Rossi, Ferdinando; Falk, Anna; Smith, Austin

    2013-07-24

    Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, differentiation capacity. Pluripotent stem cells are an alternative source, but to ascertain definitively the identity and fidelity of cell types generated solely in vitro is problematic. Here, we show that hindbrain neuroepithelial stem (hbNES) cells can be derived and massively expanded from early human embryos (week 5-7, Carnegie stage 15-17). These cell lines are propagated in adherent culture in the presence of EGF and FGF2 and retain progenitor characteristics, including SOX1 expression, formation of rosette-like structures, and high neurogenic capacity. They generate GABAergic, glutamatergic and, at lower frequency, serotonergic neurons. Importantly, hbNES cells stably maintain hindbrain specification and generate upper rhombic lip derivatives on exposure to bone morphogenetic protein (BMP). When grafted into neonatal rat brain, they show potential for integration into cerebellar development and produce cerebellar granule-like cells, albeit at low frequency. hbNES cells offer a new system to study human cerebellar specification and development and to model diseases of the hindbrain. They also provide a benchmark for the production of similar long-term neuroepithelial-like stem cells (lt-NES) from pluripotent cell lines. To our knowledge, hbNES cells are the first demonstration of highly expandable neuroepithelial stem cells derived from the human embryo without genetic immortalization.

  20. Establishment of Stably Transfected Cells Constitutively Expressing the Full-Length and Truncated Antigenic Proteins of Two Genetically Distinct Mink Astroviruses

    DEFF Research Database (Denmark)

    Bidokhti, Mehdi R. M.; Ullman, Karin; Jensen, Trine Hammer

    2013-01-01

    to circumvent this drawback, we have developed stably transfected mink fetal cells and BHK21 cells constitutively expressing the full-length and truncated capsid proteins of two distinct genotypes of mink astrovirus. Protein expression in these stably transfected cells was demonstrated by strong signals...

  1. A study of stratified gas-liquid pipe flow

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, George W.

    2005-07-01

    liquid accumulation in large gas condensate pipelines. Reducing the prediction uncertainties can lead to more optimal pipeline dimensioning, thus potentially reducing both costs and technical risks. The chapters may be summarized by the following. 1) Outlines the stratified two-fluid model in pipes which provides a basis for the theoretical models of this work. Assumptions and simplifications which result in the model equations are presented. Some relationships which were used to analyze the experimental data are also presented. 2) Discusses theoretical models and experimental investigations from the literature involving stratified flow inducts. 3) Presents a new mathematical model for stratified flow in inclined pipes which allow predictive discontinuous and continuous roll wave solutions. 4) Describes the facility used for the experimental work and data reduction methods. 5) Presents experimental results from horizontal and inclined two-phase pipe flow at 8 bara. 6) Compares model predictions with experimental observations. 7) Summarizes the ability of the models to predict the observational data and suggest further improvements. Draws conclusions about the ability of the models to predict observed quantities. (Author)

  2. Identifying stably expressed housekeeping genes in the endometrium of fertile women, women with recurrent implantation failure and recurrent miscarriages

    OpenAIRE

    Stocker, Linden; Cagampang, Felino; Cheong, Ying

    2017-01-01

    Housekeeping genes (HKG) are presumed to be constitutively expressed throughout tissue types but recent studies have shown they vary with pathophysiology. Often, validation of appropriate HKG is not made. There is no consensus on which HKGs are most stably expressed in endometrial tissue so this study aimed to identify the most stable HKG in the endometrium of women with recurrent implantation failure (RIF) and recurrent miscarriages (RM). Inclusion criteria were women between 25-45 years (...

  3. Assembly of homotrimeric type XXI minicollagen by coexpression of prolyl 4-hydroxylase in stably transfected Drosophila melanogaster S2 cells.

    Science.gov (United States)

    Li, Hsiu-Chuan; Huang, Chuan-Chuan; Chen, Sung-Fang; Chou, Min-Yuan

    2005-10-21

    We established stably transfected insect cell lines containing cDNAs encoding the alpha and beta subunits of human prolyl 4-hydroxylase in both Trichoplusia ni and Drosophila melanogaster S2 cells. The expression level and enzymatic activity of recombinant prolyl 4-hydroxylase produced in the Drosophila expression system were significantly higher than those produced in the T. ni system. We further characterized the involvement of prolyl 4-hydroxylase in the assembly of the three alpha chains to form trimeric type XXI minicollagen, which comprises the intact C-terminal non-collagenous (NC1) and collagenous domain (COL1), in the Drosophila system. When minicollagen XXI was stably expressed in Drosophila S2 cells alone, negligible amounts of interchain disulfide-bonded trimers were detected in the culture media. However, minicollagen XXI was secreted as disulfide-bonded homotrimers by coexpression with prolyl 4-hydroxylase in the stably transfected Drosophila S2 cells. Minicollagen XXI coexpressed with prolyl 4-hydroxylase contained sufficient amounts of hydroxyproline to form thermal stable pepsin-resistant triple helices consisting of both interchain and non-interchain disulfide-bonded trimers. These results demonstrate that a sufficient amount of active prolyl 4-hydroxylase is required for the assembly of type XXI collagen triple helices in Drosophila cells and the trimeric assembly is governed by the C-terminal collagenous domain.

  4. Classification of archaeologically stratified pumice by INAA

    International Nuclear Information System (INIS)

    Peltz, C.; Bichler, M.

    2001-01-01

    In the framework of the research program 'Synchronization of Civilization in the Eastern Mediterranean Region in the 2nd Millenium B.C.' instrumental neutron activation analysis (INAA) was used to determine 30 elements in pumice from archaeological excavations to reveal their specific volcanic origin. The widespread pumiceous products of several eruptions in the Aegean region were used as abrasive tools and were therefore popular trade objects. A remarkable quantity of pumice and pumiceous tephra (several km 3 ) was produced by the 'Minoan eruption' of Thera (Santorini), which is assumed to have happened between 1450 and 1650 B.C. Thus the discovery of the primary fallout of 'Minoan' tephra in archaeologically stratified locations can be used as a relative time mark. Additionally, pumice lumps used as abrasive can serve for dating by first appearance. Essential to an identification of the primary volcanic source is the knowledge that pumices from the Aegean region can easily be distinguished by their trace element distribution patterns, as previous work has shown. The elements Al, Ba, Ca, Ce, Co, Cr, Cs, Dy, Eu, Fe, Hf, K, La, Lu, Mn, Na, Nd, Rb, Sb, Sc, Sm, Ta, Tb, Th, Ti, U, V, Yb, Zn and Zr were determined in 16 samples of pumice lumps from excavations in Tell-el-Dab'a and Tell-el-Herr (Egypt). Two irradiation cycles and five measurement runs were applied. A reliable identification of the samples is achieved by comparing these results to the database compiled in previous studies. (author)

  5. Mercury biogeochemical cycling in a stratified estuary

    Energy Technology Data Exchange (ETDEWEB)

    Mason, R.P.; Fitzgerald, W.F. (Univ. of Connecticut, Groton, CT (United States)); Hurley, J. (Wisconsin DNR, Fitchburg, WI (United States)); Hanson, A.K. Jr.; Donaghay, P.L.; Sieburth, J.M. (Univ. of Rhode Island, Narragansett, RI (United States))

    1993-09-01

    Total Hg in the permanently stratified Pettaquamscutt estuary was <25 pM throughout the water column, even in highly sulfidic bottom waters. Particulate Hg was typically >40% of the total Hg. Reactive Hg (Hg[sub R]) was generally <3 pM and decreased with depth, but there is Hg[sub R] even in the anoxic bottom waters. Elemental Hg (Hg[sup 0]) was highest in the mixed layer and below the detection limit at depth. Demethylation is not an important source of Hg[sup 0] in this estuary. Dimethylmercury was not detected. Monomethylmercury (MMHg) was near the detection limit in the mixed layer and increased rapidly in the low oxygen region. Dissolved MMHg correlated with bacteriochlorophyll pigments, suggesting that the microbial community plays an important role in MMHg production in the estuary. The overall distributions of dissolved and particulate Hg species result from the interaction with Fe and Mn redox cycling, particulate scavenging and sinking, and MMHg production in the pycnocline. The estimated rate of MMHg production from Hg[sub R] in the pycnocline region is 1.7% d[sup [minus]1]. Hg[sup 0] and MMHg are formed principally in the mixed layer and in the pycnocline region, respectively. Particulate scavenging is important, and sedimentation, methylation, and Hg[sup 0] production are the principal sinks for Hg[sub R].

  6. Spiral arms in thermally stratified protoplanetary discs

    Science.gov (United States)

    Juhász, Attila; Rosotti, Giovanni P.

    2018-02-01

    Spiral arms have been observed in nearly a dozen protoplanetary discs in near-infrared scattered light and recently also in the submillimetre continuum. While one of the most compelling explanations is that they are driven by planetary or stellar companions, in all but one cases such companions have not yet been detected and there is even ambiguity on whether the planet should be located inside or outside the spirals. Here, we use 3D hydrodynamic simulations to study the morphology of spiral density waves launched by embedded planets taking into account the vertical temperature gradient, a natural consequence of stellar irradiation. Our simulations show that the pitch angle of the spirals in thermally stratified discs is the lowest in the disc mid-plane and increases towards the disc surface. We combine the hydrodynamic simulations with 3D radiative transfer calculations to predict that the pitch angle of planetary spirals observed in the near-infrared is higher than in the submillimetre. We also find that in both cases the spirals converge towards the planet. This provides a new powerful observational method to determine if the perturbing planet is inside or outside the spirals, as well as map the thermal stratification of the disc.

  7. Experimental study of unsteady thermally stratified flow

    International Nuclear Information System (INIS)

    Lee, Sang Jun; Chung, Myung Kyoon

    1985-01-01

    Unsteady thermally stratified flow caused by two-dimensional surface discharge of warm water into a oblong channel was investigated. Experimental study was focused on the rapidly developing thermal diffusion at small Richardson number. The basic objectives were to study the interfacial mixing between a flowing layer of warm water and an underlying body of cold water and to accumulate experimental data to test computational turbulence models. Mean velocity field measurements were carried out by using NMR-CT(Nuclear Magnetic Resonance-Computerized Tomography). It detects quantitative flow image of any desired section in any direction of flow in short time. Results show that at small Richardson number warm layer rapidly penetrates into the cold layer because of strong turbulent mixing and instability between the two layers. It is found that the transfer of heat across the interface is more vigorous than that of momentum. It is also proved that the NMR-CT technique is a very valuable tool to measure unsteady three dimensional flow field. (Author)

  8. Improved patient selection by stratified surgical intervention

    DEFF Research Database (Denmark)

    Wang, Miao; Bünger, Cody E; Li, Haisheng

    2015-01-01

    BACKGROUND CONTEXT: Choosing the best surgical treatment for patients with spinal metastases remains a significant challenge for spine surgeons. There is currently no gold standard for surgical treatments. The Aarhus Spinal Metastases Algorithm (ASMA) was established to help surgeons choose...... the most appropriate surgical intervention for patients with spinal metastases. PURPOSE: The purpose of this study was to evaluate the clinical outcome of stratified surgical interventions based on the ASMA, which combines life expectancy and the anatomical classification of patients with spinal metastases...... survival times in the five surgical groups determined by the ASMA were 2.1 (TS 0-4, TC 1-7), 5.1 (TS 5-8, TC 1-7), 12.1 (TS 9-11, TC 1-7 or TS 12-15, TC 7), 26.0 (TS 12-15, TC 4-6), and 36.0 (TS 12-15, TC 1-3) months. The 30-day mortality rate was 7.5%. Postoperative neurological function was maintained...

  9. Characterising the structure of quasi-periodic mixing events in stratified turbulent Taylor-Couette flow

    Science.gov (United States)

    Singh, Kanwar Nain; Partridge, Jamie; Dalziel, Stuart; Caulfield, C. P.; Mathematical Underpinnings of Stratified Turbulence (MUST) Team

    2017-11-01

    We present results from experiments conducted to study mixing in a two-layer stably-stratified turbulent Taylor-Couette flow. It has previously been observed that there is a quasi-periodic mixing event located at the interface separating the layers. We observe, through conductivity probe measurements, that the power of the mixing event in the frequency spectrum of the density data at the interface is higher when measured near the inner cylinder than in the middle of the annular gap. This is consistent with Oglethorpe's (2014) hypothesis that the mixing structure is triggered near the inner cylinder, and then advects and decays or disperses radially. We also observe that at Ri =g/'Ro (RiΩi)2 7 , where Ri, Ro are the inner and outer cylinder radius, respectively, g ' the reduced gravity characterising the density jump between the layers and Ωi is the rotation rate of the inner cylinder, the power drops significantly at all radial locations, which is reminiscent of the onset of the enhanced flux regime as observed by Oglethorpe et al. (2013). We perform experiments to characterise the spatial extent and dynamics of this mixing structure using particle image velocimetry (PIV) giving further insights into this important mixing process. EPSRC programme Grant EP/K034529/1 & SGPC-CCT Scholarship.

  10. Mixed Convection Flow along a Stretching Cylinder in a Thermally Stratified Medium

    Directory of Open Access Journals (Sweden)

    Swati Mukhopadhyay

    2012-01-01

    Full Text Available An analysis for the axisymmetric laminar boundary layer mixed convection flow of a viscous and incompressible fluid towards a stretching cylinder immersed in a thermally stratified medium is presented in this paper. Similarity transformation is employed to convert the governing partial differential equations into highly nonlinear ordinary differential equations. Numerical solutions of these equations are obtained by a shooting method. It is found that the heat transfer rate at the surface is lower for flow in a thermally stratified medium compared to that of an unstratified medium. Moreover, both the skin friction coefficient and the heat transfer rate at the surface are larger for a cylinder compared to that for a flat plate.

  11. Nonlinear evolution of layered stratified shear flows

    Science.gov (United States)

    Lee, Victoria; Caulfield, Colm-Cille

    2000-11-01

    We investigate numerically and theoretically the nonlinear evolution of a parallel shear flow at moderate Reynolds number which has embedded within it a mixed layer of intermediate fluid. Linear stability theory predicts that such flows are unstable to stationary vortical disturbances which are a generalization of an inviscid instability first considered by G. I. Taylor. We investigate the behaviour of these Taylor modes at finite amplitude through numerical simulations. Through considering the long-time evolution of such flows, we investigate how secondary instabilities, and the layered background density profile, affect merging between neighbouring Taylor billows, and alter the irreversible mixing of the background stratification as the flow undergoes transition to small-scale disorder.

  12. Effect of FLR correction on Rayleigh -Taylor instability of quantum and stratified plasma

    International Nuclear Information System (INIS)

    Sharma, P.K.; Tiwari, Anita; Argal, Shraddha; Chhajlani, R.K.

    2013-01-01

    The Rayleigh Taylor instability of stratified incompressible fluids is studied in presence of FLR Correction and quantum effects in bounded medium. The Quantum magneto hydrodynamic equations of the problem are solved by using normal mode analysis method. A dispersion relation is carried out for the case where plasma is bounded by two rigid planes z = 0 and z = h. The dispersion relation is obtained in dimensionless form to discuss the growth rate of Rayleigh Taylor instability in presence of FLR Correction and quantum effects. The stabilizing or destabilizing behavior of quantum effect and FLR correction on the Rayleigh Taylor instability is analyzed. (author)

  13. Estimation of instantaneous heat transfer coefficients for a direct-injection stratified-charge rotary engine

    Science.gov (United States)

    Lee, C. M.; Addy, H. E.; Bond, T. H.; Chun, K. S.; Lu, C. Y.

    1987-01-01

    The main objective of this report was to derive equations to estimate heat transfer coefficients in both the combustion chamber and coolant pasage of a rotary engine. This was accomplished by making detailed temperature and pressure measurements in a direct-injection stratified-charge rotary engine under a range of conditions. For each sppecific measurement point, the local physical properties of the fluids were calculated. Then an empirical correlation of the coefficients was derived by using a multiple regression program. This correlation expresses the Nusselt number as a function of the Prandtl number and Reynolds number.

  14. Water Tank Experiments on Stratified Flow over Double Mountain-Shaped Obstacles at High-Reynolds Number

    Directory of Open Access Journals (Sweden)

    Ivana Stiperski

    2017-01-01

    Full Text Available In this article, we present an overview of the HyIV-CNRS-SecORo (Hydralab IV-CNRS-Secondary Orography and Rotors Experiments laboratory experiments carried out in the CNRM (Centre National de Recherches Météorologiques large stratified water flume. The experiments were designed to systematically study the influence of double obstacles on stably stratified flow. The experimental set-up consists of a two-layer flow in the water tank, with a lower neutral and an upper stable layer separated by a sharp density discontinuity. This type of layering over terrain is known to be conducive to a variety of possible responses in the atmosphere, from hydraulic jumps to lee waves and highly turbulent rotors. In each experiment, obstacles were towed through the tank at a constant speed. The towing speed and the size of the tank allowed high Reynolds-number flow similar to the atmosphere. Here, we present the experimental design, together with an overview of laboratory experiments conducted and their results. We develop a regime diagram for flow over single and double obstacles and examine the parameter space where the secondary obstacle has the largest influence on the flow. Trapped lee waves, rotors, hydraulic jumps, lee-wave interference and flushing of the valley atmosphere are successfully reproduced in the stratified water tank. Obstacle height and ridge separation distance are shown to control lee-wave interference. Results, however, differ partially from previous findings on the flow over double ridges reported in the literature due to the presence of nonlinearities and possible differences in the boundary layer structure. The secondary obstacle also influences the transition between different flow regimes and makes trapped lee waves possible for higher Froude numbers than expected for an isolated obstacle.

  15. Stably transfected human cell lines as fluorescent screening assay for nuclear factor KB activation dependent gene expression

    Science.gov (United States)

    Hellweg, Christine E.; Baumstark-Khan, Christa; Horneck, Gerda

    2004-06-01

    Activation of the Nuclear Factor kappaB (NF-kappaB) pathway as a possible antiapoptotic route represents one important cellular stress response. For identifying conditions which are capable to modify this pathway, a screening assay for detection of NF-kappaB-dependent gene activation using the reporter proteins Enhanced Green Fluorescent Protein (EGFP) and its destabilized variant (d2EGFP) has been developed. Human Embryonic Kidney (HEK/293) cells were stably transfected with a vector carrying EGFP or d2EGFP under control of a synthetic promoter containing four copies of the NF-kappaB response element. Treatment with tumor necrosis factor alpha (TNF-alpha) gave rise to substantial EGFP / d2EGFP expression in up to 90 % of the cells and was therefore used to screen different stably transfected clones for induction of NF-kappaB dependent gene expression. The time course of d2EGFP expression after treatment with TNF-alpha or phorbol ester was measured using flow cytometry. Cellular response to TNF-alpha was faster than to phorbol ester. Treatment of cells with TNF-alpha and DMSO revealed antagonistic interactions of these substances in the activation NF-kappaB dependent gene expression. The detection of d2EGFP expression required FACS analysis or fluorescence microscopy, while EGFP could also be measured in the microplate reader, rendering the assay useful for high-throughput screening.

  16. The stratified H-index makes scientific impact transparent

    DEFF Research Database (Denmark)

    Würtz, Morten; Schmidt, Morten

    2017-01-01

    The H-index is widely used to quantify and standardize researchers' scientific impact. However, the H-index does not account for the fact that co-authors rarely contribute equally to a paper. Accordingly, we propose the use of a stratified H-index to measure scientific impact. The stratified H......-index supplements the conventional H-index with three separate H-indices: one for first authorships, one for second authorships and one for last authorships. The stratified H-index takes scientific output, quality and individual author contribution into account....

  17. Stratified flows and internal waves in the Vema Fracture Zone of the Mid Atlantic Ridge

    Science.gov (United States)

    Makarenko, Nikolay; Morozov, Eugene; Tarakanov, Roman; Demidova, Tatiana; Frey, Dmitri; Grigorenko, Klim

    2017-04-01

    In this paper, we study stratified flows and internal waves in the Vema fracture zone of the Mid Atlantic Ridge. This fracture provides intense transportation of cold abyssal waters from the West Atlantic to the equatorial region of the East Atlantic [1]. The results of measurements [2,3] carried out in the cruises of RV Akademik Sergey Vavilov in 2014-2016 are presented. The structure of the near-bottom flow is studied experimentally on the basis of CTD- and LADCP profiling. Theoretical analysis involves mathematical formulation of stratified fluid flow which uses CTD-data obtained from field observation. Spectral properties and kinematic characteristics of internal waves are calculated and discussed. This work was supported by RFBR (grants No 15-01-03942, 16-35-50158). References [1] Morozov E., Demidov A., Tarakanov R. and Zenk W. Abyssal Channels in the Atlantic Ocean: Water Structure and Flows, Springer, Dordrecht, 2010. [2] Morozov E.G., Tarakanov R.Yu., and Makarenko N.I. Flows of Antarctic Bottom Water through fractures in the southern part of the North Mid Atlantic Ridge, Oceanology, 2015, 55, 796-800. [3] Grigorenko K.S., Makarenko N.I., Morozov E.G., Tarakanov R.Yu., and Frey D.I. Stratified flows and internal waves in the Central West Atlantic, J. Physics: Conf. Series, 2016, 722, 012011.

  18. Jet-mixing of initially-stratified liquid-liquid pipe flows: experiments and numerical simulations

    Science.gov (United States)

    Wright, Stuart; Ibarra-Hernandes, Roberto; Xie, Zhihua; Markides, Christos; Matar, Omar

    2016-11-01

    Low pipeline velocities lead to stratification and so-called 'phase slip' in horizontal liquid-liquid flows due to differences in liquid densities and viscosities. Stratified flows have no suitable single point for sampling, from which average phase properties (e.g. fractions) can be established. Inline mixing, achieved by static mixers or jets in cross-flow (JICF), is often used to overcome liquid-liquid stratification by establishing unstable two-phase dispersions for sampling. Achieving dispersions in liquid-liquid pipeline flows using JICF is the subject of this experimental and modelling work. The experimental facility involves a matched refractive index liquid-liquid-solid system, featuring an ETFE test section, and experimental liquids which are silicone oil and a 51-wt% glycerol solution. The matching then allows the dispersed fluid phase fractions and velocity fields to be established through advanced optical techniques, namely PLIF (for phase) and PTV or PIV (for velocity fields). CFD codes using the volume of a fluid (VOF) method are then used to demonstrate JICF breakup and dispersion in stratified pipeline flows. A number of simple jet configurations are described and their dispersion effectiveness is compared with the experimental results. Funding from Cameron for Ph.D. studentship (SW) gratefully acknowledged.

  19. Nambu brackets in fluid mechanics and magnetohydrodynamics

    International Nuclear Information System (INIS)

    Salazar, Roberto; Kurgansky, Michael V

    2010-01-01

    Concrete examples of the construction of Nambu brackets for equations of motion (both 3D and 2D) of Boussinesq stratified fluids and also for magnetohydrodynamical equations are given. It serves a generalization of Hamiltonian formulation for the considered equations of motion. Two alternative Nambu formulations are proposed, first by using fluid dynamical (kinetic) helicity and/or enstrophy as constitutive elements and second, by using the existing conservation laws of the governing equation.

  20. The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha(1A1)-adrenoceptors

    DEFF Research Database (Denmark)

    Nourian, Zahra; Mulvany, Michael J; Nielsen, Karsten Bork

    2008-01-01

    Antipsychotic drugs often cause orthostatic hypotension, probably through antagonist action on resistance vessel alpha(1A)-adrenoceptors. Here we have tested this possibility directly using cells transfected with a relevant human alpha(1A)-adrenoceptor splice variant. To determine a splice variant...... a cell line stably expressing a functional form of this splice variant. The expression of recombinant alpha(1A1)-adrenoceptor subtype was confirmed by Western immunoblot analysis, and its functionality demonstrated using a Fura-2 assay by a rise in intracellular calcium concentration ([Ca(2+)](i)) when...... human alpha(1A1)-adrenoceptors in competition binding studies confirmed much higher antagonist affinity of sertindole and risperidone than haloperidol for these receptors. In summary, it can be concluded that there is an approximately 10-fold higher adrenoceptor affinity of risperidone and sertindole...

  1. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  2. Fluid Interfaces

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius

    2001-01-01

    Fluid interaction, interaction by the user with the system that causes few breakdowns, is essential to many user interfaces. We present two concrete software systems that try to support fluid interaction for different work practices. Furthermore, we present specificity, generality, and minimality...... as design goals for fluid interfaces....

  3. 21-Methylpyrenyl-cholesterol stably and specifically associates with lipoprotein peripheral hemi-membrane: A new labelling tool

    International Nuclear Information System (INIS)

    Gaibelet, Gérald; Tercé, François; Bertrand-Michel, Justine; Allart, Sophie; Azalbert, Vincent; Lecompte, Marie-France; Collet, Xavier; Orlowski, Stéphane

    2013-01-01

    Highlights: •21-Methylpyrenyl-cholesterol specifically and stably associates to lipoproteins. •It is not esterified by LCAT, and thus reliably labels their peripheral hemi-membrane. •HDL vs. LDL are well distinguishable by various fluorescent labelling characteristics. •LDL peripheral hemi-membrane harbors cholesterol-rich ordered lipid (micro)domains. •Cultured cells can be stained by such labelled lipoproteins-mediated delivery. -- Abstract: Lipoproteins are important biological components. However, they have few convenient fluorescent labelling probes currently reported, and their physiological reliability can be questioned. We compared the association of two fluorescent cholesterol derivatives, 22-nitrobenzoxadiazole-cholesterol (NBD-Chol) and 21-methylpyrenyl-cholesterol (Pyr-met-Chol), to serum lipoproteins and to purified HDL and LDL. Both lipoproteins could be stably labelled by Pyr-met-Chol, but virtually not by NBD-Chol. At variance with NBD-Chol, LCAT did not esterify Pyr-met-Chol. The labelling characteristics of lipoproteins by Pyr-met-Chol were well distinguishable between HDL and LDL, regarding dializability, associated probe amount and labelling kinetics. We took benefit of the pyrene labelling to approach the structural organization of LDL peripheral hemi-membrane, since Pyr-met-Chol-labelled LDL, but not HDL, presented a fluorescence emission of pyrene excimers, indicating that the probe was present in an ordered lipid micro-environment. Since the peripheral membrane of LDL contains more sphingomyelin (SM) than HDL, this excimer formation was consistent with the existence of cholesterol- and SM-enriched lipid microdomains in LDL, as already suggested in model membranes of similar composition and reminiscent to the well-described “lipid rafts” in bilayer membranes. Finally, we showed that Pyr-met-Chol could stain cultured PC-3 cells via lipoprotein-mediated delivery, with a staining pattern well different to that observed with NBD

  4. 21-Methylpyrenyl-cholesterol stably and specifically associates with lipoprotein peripheral hemi-membrane: A new labelling tool

    Energy Technology Data Exchange (ETDEWEB)

    Gaibelet, Gérald [INSERM U563, CHU Purpan, Toulouse (France); CEA, SB2SM and UMR8221 CNRS, IBiTec-Saclay, Gif-sur-Yvette (France); Tercé, François [Université Toulouse III, UMR 1048, Toulouse (France); INSERM U1048, Toulouse (France); Bertrand-Michel, Justine [Université Toulouse III, UMR 1048, Toulouse (France); INSERM U1048, Lipidomic Platform Metatoul, Toulouse (France); Allart, Sophie [Plateau Technique d’Imagerie Cellulaire, INSERM U1043, Toulouse (France); Azalbert, Vincent [Université Toulouse III, UMR 1048, Toulouse (France); INSERM U1048, Toulouse (France); Lecompte, Marie-France [INSERM U563, Faculté de Médecine de Rangueil, Toulouse (France); Collet, Xavier [Université Toulouse III, UMR 1048, Toulouse (France); INSERM U1048, Toulouse (France); Orlowski, Stéphane, E-mail: stephane.orlowski@cea.fr [INSERM U563, CHU Purpan, Toulouse (France); CEA, SB2SM and UMR8221 CNRS, IBiTec-Saclay, Gif-sur-Yvette (France)

    2013-11-01

    Highlights: •21-Methylpyrenyl-cholesterol specifically and stably associates to lipoproteins. •It is not esterified by LCAT, and thus reliably labels their peripheral hemi-membrane. •HDL vs. LDL are well distinguishable by various fluorescent labelling characteristics. •LDL peripheral hemi-membrane harbors cholesterol-rich ordered lipid (micro)domains. •Cultured cells can be stained by such labelled lipoproteins-mediated delivery. -- Abstract: Lipoproteins are important biological components. However, they have few convenient fluorescent labelling probes currently reported, and their physiological reliability can be questioned. We compared the association of two fluorescent cholesterol derivatives, 22-nitrobenzoxadiazole-cholesterol (NBD-Chol) and 21-methylpyrenyl-cholesterol (Pyr-met-Chol), to serum lipoproteins and to purified HDL and LDL. Both lipoproteins could be stably labelled by Pyr-met-Chol, but virtually not by NBD-Chol. At variance with NBD-Chol, LCAT did not esterify Pyr-met-Chol. The labelling characteristics of lipoproteins by Pyr-met-Chol were well distinguishable between HDL and LDL, regarding dializability, associated probe amount and labelling kinetics. We took benefit of the pyrene labelling to approach the structural organization of LDL peripheral hemi-membrane, since Pyr-met-Chol-labelled LDL, but not HDL, presented a fluorescence emission of pyrene excimers, indicating that the probe was present in an ordered lipid micro-environment. Since the peripheral membrane of LDL contains more sphingomyelin (SM) than HDL, this excimer formation was consistent with the existence of cholesterol- and SM-enriched lipid microdomains in LDL, as already suggested in model membranes of similar composition and reminiscent to the well-described “lipid rafts” in bilayer membranes. Finally, we showed that Pyr-met-Chol could stain cultured PC-3 cells via lipoprotein-mediated delivery, with a staining pattern well different to that observed with NBD

  5. Fluid dynamics of dilatant fluid

    DEFF Research Database (Denmark)

    Nakanishi, Hiizu; Nagahiro, Shin-ichiro; Mitarai, Namiko

    2012-01-01

    A dense mixture of granules and liquid often shows a severe shear thickening and is called a dilatant fluid. We construct a fluid dynamics model for the dilatant fluid by introducing a phenomenological state variable for a local state of dispersed particles. With simple assumptions for an equation...

  6. On the Difference between Waves and Turbulence in a Stratified Fluid.

    Science.gov (United States)

    1982-11-02

    applications concerning pollution transport and chemistry , -is ,ckl as optic’al turbulence, it is the mixing property of turbulence that is the inic of...8217 Mended "aves but, instead, at sho’t- iv’’’. hi’\\-,-!’a’az’d htodesf Q Wsturbinue or eddFies. One is considering a Wace ’ I) ct an or ahsuimblae of...Geophjs. Hes. f 𔃾:222-222.1 Shur, G. N. (1!(;2) Experimental studies of the energy spectrum of atmos- spheric turbulence. Proceedings of the Central

  7. A review on rising bubble dynamics in viscosity-stratified fluids

    Indian Academy of Sciences (India)

    Kirti Chandra Sahu

    example, in the ice-cream and lotion industries, by the addition of only 2% carboxymethylcellulose (CMC) the viscosity of water or milk is made to increase by almost three orders of magnitude, while keeping the density con- stant [5]. The presence of temperature and concentration gradients also creates a variation of the ...

  8. The Near Wake of Bluff Bodies in Stratified Fluids and the Emergence of Late Wake Characteristics

    Science.gov (United States)

    2010-10-29

    over the course of 1 shedding cycle is presented in Figure 4.11. Qualitatively, it is apparent that the sign of LUZ on either side of the x-axis...similarity model about thirty years ago led to the realization that subgrid scale models that do not use eddy viscosity concepts are possible and have many

  9. Fluids engineering

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Fluids engineering has played an important role in many applications, from ancient flood control to the design of high-speed compact turbomachinery. New applications of fluids engineering, such as in high-technology materials processing, biotechnology, and advanced combustion systems, have kept up unwaining interest in the subject. More accurate and sophisticated computational and measurement techniques are also constantly being developed and refined. On a more fundamental level, nonlinear dynamics and chaotic behavior of fluid flow are no longer an intellectual curiosity and fluid engineers are increasingly interested in finding practical applications for these emerging sciences. Applications of fluid technology to new areas, as well as the need to improve the design and to enhance the flexibility and reliability of flow-related machines and devices will continue to spur interest in fluids engineering. The objectives of the present seminar were: to exchange current information on arts, science, and technology of fluids engineering; to promote scientific cooperation between the fluids engineering communities of both nations, and to provide an opportunity for the participants and their colleagues to explore possible joint research programs in topics of high priority and mutual interest to both countries. The Seminar provided an excellent forum for reviewing the current state and future needs of fluids engineering for the two nations. With the Seminar ear-marking the first formal scientific exchange between Korea and the United States in the area of fluids engineering, the scope was deliberately left broad and general

  10. Improvements to TRAC models of condensing stratified flow. Pt. 2

    International Nuclear Information System (INIS)

    Zhang, Q.; Leslie, D.C.; Hewitt, G.F.

    1991-03-01

    The Bankoff experiments of condensation in counter-current stratified flow have been simulated by TRAC-PF1/MOD1 and modified TRAC with Bankoff's own correlations of interfacial friction and interfacial heat transfer coefficient (HTC). Steam flow rate and liquid height have been evaluated. Both TRAC and Bankoff HTCs are strongly dependant on the liquid velocity which is related to the liquid height. The calculations show that Bankoff HTC is much better than the TRAC HTC in the prediction of the stream flow rate and is recommended to replace TRAC HTC in the condensing stratified flow. (author)

  11. Fluid machinery

    International Nuclear Information System (INIS)

    Ha, Jae Hyeon; Son, Byeong Jin

    2001-04-01

    This book tells of definition and classification of fluid machinery, energy equation of incompressible fluid, principle of momentum, classification and structure of pump, size, safety of centrifugal pump, theory and operation of contraction pump, reciprocating pump, rotary pump, special pump, using of water power, classification of water turbine, impulse water turbine, reaction water turbine, pump water turbine, liquid movement apparatus, fluid type control machinery and solid and gas type pneumatic machine.

  12. Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs.

    Science.gov (United States)

    Lu, Yongbo; Kamel-El Sayed, Suzan A; Wang, Kun; Tiede-Lewis, LeAnn M; Grillo, Michael A; Veno, Patricia A; Dusevich, Vladimir; Phillips, Charlotte L; Bonewald, Lynda F; Dallas, Sarah L

    2018-02-20

    Type I collagen is the most abundant extracellular matrix protein in bone and other connective tissues and plays key roles in normal and pathological bone formation as well as in connective tissue disorders and fibrosis. Although much is known about the collagen biosynthetic pathway and its regulatory steps, the mechanisms by which it is assembled extracellularly are less clear. We have generated GFPtpz and mCherry-tagged collagen fusion constructs for live imaging of type I collagen assembly by replacing the α2(I)-procollagen N-terminal propeptide with GFPtpz or mCherry. These novel imaging probes were stably transfected into MLO-A5 osteoblast-like cells and fibronectin-null mouse embryonic fibroblasts (FN-null-MEFs) and used for imaging type I collagen assembly dynamics and its dependence on fibronectin. Both fusion proteins co-precipitated with α1(I)-collagen and remained intracellular without ascorbate but were assembled into α1(I) collagen-containing extracellular fibrils in the presence of ascorbate. Immunogold-EM confirmed their ultrastuctural localization in banded collagen fibrils. Live cell imaging in stably transfected MLO-A5 cells revealed the highly dynamic nature of collagen assembly and showed that during assembly the fibril networks are continually stretched and contracted due to the underlying cell motion. We also observed that cell-generated forces can physically reshape the collagen fibrils. Using co-cultures of mCherry- and GFPtpz-collagen expressing cells, we show that multiple cells contribute collagen to form collagen fiber bundles. Immuno-EM further showed that individual collagen fibrils can receive contributions of collagen from more than one cell. Live cell imaging in FN-null-MEFs expressing GFPtpz-collagen showed that collagen assembly was both dependent upon and dynamically integrated with fibronectin assembly. These GFP-collagen fusion constructs provide a powerful tool for imaging collagen in living cells and have revealed novel

  13. Magnetic Field in the Gravitationally Stratified Coronal Loops B. N. ...

    Indian Academy of Sciences (India)

    crucial especially in the magnetic field measurement of longer and long-lived coro- nal structures. The negligence of this factor causes a large amount of uncertainty in the estimation of magnetic field. This result is very important in keeping with the view of the evolution of kink waves in gravitationally stratified coronal loops.

  14. Profiling of poorly stratified atmospheres with scanning lidar

    Science.gov (United States)

    C. E. Wold; V. A. Kovalev; A. P. Petkov; W. M. Hao

    2012-01-01

    The direct multiangle solution may allow inversion of the scanning lidar data even when the requirement of the horizontally stratified atmosphere is poorly met. The solution is based on two principles: (1) The signal measured in zenith is the core source for extracting the information about the atmospheric aerosol loading, and (2) The multiangle signals are used as...

  15. Economic Evaluation in Stratified Medicine : Methodological Issues and Challenges

    NARCIS (Netherlands)

    Fugel, Hans-Joerg; Nuijten, Mark; Postma, Maarten; Redekop, Ken

    2016-01-01

    Background: Stratified Medicine (SM) is becoming a practical reality with the targeting of medicines by using a biomarker or genetic-based diagnostic to identify the eligible patient sub-population. Like any healthcare intervention, SM interventions have costs and consequences that must be

  16. Economic evaluation in stratified medicine: Methodological issues and challenges

    NARCIS (Netherlands)

    Fugel, H.-J. (Hans-Joerg); M.J.C. Nuijten (Mark); M.J. Postma (Maarten); W.K. Redekop (Ken)

    2016-01-01

    textabstractBackground: Stratified Medicine (SM) is becoming a practical reality with the targeting of medicines by using a biomarker or genetic-based diagnostic to identify the eligible patient sub-population. Like any healthcare intervention, SM interventions have costs and consequences that must

  17. Stratified Outcome Evaluation of Peritonitis | Wabwire | Annals of ...

    African Journals Online (AJOL)

    Background: The heterogeneity of disease severity in peritonitis makes outcome prediction challenging. Risk evaluation in secondary peritonitis can direct treatment planning, predict outcomes and aid in the conduct of surgical audits. Objective: To determine the outcome of peritonitis in patients stratified according to ...

  18. Plane Stratified Flow in a Room Ventilated by Displacement Ventilation

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm; Nickel, J.; Baron, D. J. G.

    2004-01-01

    The air movement in the occupied zone of a room ventilated by displacement ventilation exists as a stratified flow along the floor. This flow can be radial or plane according to the number of wall-mounted diffusers and the room geometry. The paper addresses the situations where plane flow...

  19. On Internal Waves in a Density-Stratified Estuary

    NARCIS (Netherlands)

    Kranenburg, C.

    1991-01-01

    In this article some field observations, made in recent years, of internal wave motions in a density-stratified estuary are presented, In order to facilitate the appreciation of the results, and to make some quantitative comparisons, the relevant theory is also summarized. Furthermore, the origins

  20. Bacterial production, protozoan grazing, and mineralization in stratified Lake Vechten

    NARCIS (Netherlands)

    Bloem, J.

    1989-01-01

    The role of heterotrophic nanoflagellates (HNAN, size 2-20 μm) in grazing on bacteria and mineralization of organic matter in stratified Lake Vechten was studied.

    Quantitative effects of manipulation and fixation on HNAN were checked. Considerable losses were caused by

  1. On the Jeans Criterion of a Stratified Heat Conducting Gaseous ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Home; Journals; Journal of Astrophysics and Astronomy; Volume 33; Issue 4. On the Jeans Criterion of a Stratified Heat Conducting Gaseous Medium in the Presence of Non-Uniform Rotation and Magnetic Field. Joginder S. Dhiman Rekha Dadwal. Volume 33 Issue 4 December 2012 pp 363-373 ...

  2. On the Jeans Criterion of a Stratified Heat Conducting Gaseous ...

    Indian Academy of Sciences (India)

    homogeneous stratified gaseous medium with finite thermal conductiv- ity and infinite electrical conductivity, in the presence of non-uniform rotation and magnetic field in the Chandrasekhar's frame of reference, is studied. It is found that the magnetic field, whether uniform or non- uniform, has no effect on the Jeans' criterion ...

  3. A structured e-content development framework using a stratified ...

    African Journals Online (AJOL)

    The paper discusses a stratified objectives-driven e-content structuring and deployment framework which is an iterative and intuitive approach to content structuring and sequencing. The model has been developed from experiences and insights gained over a four-stage content development training process involving ...

  4. THE EVALUATION OF PEPTIDE/HISTIDINE TRANSPORTER 1 (PHT1) FUNCTION: UPTAKE KINETICS UTILIZING A COS-7 STABLY TRANSFECTED CELL LINE.

    Science.gov (United States)

    Lindley, David J; Carl, Stephen M; Mowery, Stephanie A; Knipp, Gregory T

    2011-10-01

    There have been relatively few studies focused on the proton-dependent oligopeptide transporter (POT) superfamily member, Peptide/Histidine Transporter 1 (PHT1), with respect to its contribution to the ADME of peptides and peptide-based drugs. These studies were conducted to determine hPHT1-mediated, H + -dependent uptake kinetics of histidine, carnosine, Gly-Sar and valacyclovir in stably transfected hPHT1-COS-7 cells comparative to kinetics determined in an empty vector (Mock) stably transfected cell line. The results suggest that Gly-Sar appears to be a substrate for PHT1 based on efflux from the stably transfected hPHT1 COS-7 cells. Histidine and Gly-Sar concentration- and time-dependent studies suggest mixed-uptake kinetics. These studies suggest that stably transfected hPHT1-COS-7 cells exhibit different uptake kinetics than those observed in our previous studies and illustrate the requirement for experiments to delineate the physiological role of hPHT1.

  5. Sensitivity and inversion of full seismic waveforms in stratified porous medium; Sensibilite et inversion de formes d'ondes completes en milieu poreux stratifie

    Energy Technology Data Exchange (ETDEWEB)

    Barros, L. de

    2007-12-15

    Characterization of porous media parameters, and particularly the porosity, permeability and fluid properties are very useful in many applications (hydrologic, natural hazards or oil industry). The aim of my research is to evaluate the possibility to determine these properties from the full seismic wave fields. First, I am interested in the useful parameters and the specific properties of the seismic waves in the poro-elastic theory, often called Biot (1956) theory. I then compute seismic waves propagation in fluid saturated stratified porous media with a reflectivity method coupled with the discrete wavenumber integration method. I first used this modeling to study the possibilities to determine the carbon dioxide concentration and localization thanks to the reflected P-waves in the case of the deep geological storage of Sleipner (North Sea). The sensitivity of the seismic response to the poro-elastic parameters are then generalized by the analytical computation of the Frechet derivatives which are expressed in terms of the Green's functions of the unperturbed medium. The numerical tests show that the porosity and the consolidation are the main parameters to invert. The sensitivity operators are then introduced in a inversion algorithm based on iterative modeling of the full waveform. The classical algorithm of generalized least-square inverse problem is solved by the quasi-Newton technique (Tarantola, 1984). The inversion of synthetic data show that we can invert for the porosity and the fluid and solid parameters (densities and mechanical modulus, or volume rate of fluid and mineral) can be correctly rebuilt if the other parameters are well known. However, the strong seismic coupling of the porous parameters leads to difficulties to invert simultaneously for several parameters. One way to get round these difficulties is to use additional information and invert for one single parameter for the fluid properties (saturating rate) or for the lithology. An other

  6. Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications.

    Science.gov (United States)

    Plundrich, N; Grace, M H; Raskin, I; Ann Lila, M

    2013-08-01

    Natural botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry. In this study, an efficient tactic is demonstrated for concentrating and stabilizing skin-beneficial bioactive compounds from muscadine grape and blackcurrant juice or muscadine pomace, into hemp flour (HF), hemp protein isolate (HPI) and soy protein isolate (SPI) matrices suitable for cosmetic applications. Anthocyanins were most efficiently captured from blackcurrant juice into HF (8.39 mg g(-1) ). HPI most effectively captured total phenolics from muscadine pomace (72.32 and 77.32 mg g(-1) from Noble and Carlos, respectively), while the three matrices incorporated highest levels of ellagic acid, gallic acid, and PAC B1 from Noble muscadine grape juice. The enriched matrices demonstrated effective in vitro inhibition of tyrosinase (up to 57.29% for blackcurrant juice-HPI matrix), and in general, juice sources provided greater inhibition on L-dopamine oxidation by tyrosinase than pomace sources. The polyphenol-enriched matrices effectively inhibited microbial proliferation in a screening assay against Staphylococcus aureus bacteria, whereas untreated HF, HPI or SPI did not inhibit bacterial growth. The technology of combining and stably concentrating phytoactive polyphenols with proteins has potential use for cosmetic topical applications. © 2013 John Wiley & Sons Ltd.

  7. Identifying stably expressed housekeeping genes in the endometrium of fertile women, women with recurrent implantation failure and recurrent miscarriages.

    Science.gov (United States)

    Stocker, Linden; Cagampang, Felino; Cheong, Ying

    2017-11-01

    Housekeeping genes (HKG) are presumed to be constitutively expressed throughout tissue types but recent studies have shown they vary with pathophysiology. Often, validation of appropriate HKG is not made. There is no consensus on which HKGs are most stably expressed in endometrial tissue so this study aimed to identify the most stable HKG in the endometrium of women with recurrent implantation failure (RIF) and recurrent miscarriages (RM). Inclusion criteria were women between 25-45 years (n = 45) suffering recurrent miscarriage (RM), recurrent implantation failure (RIF) or fertile controls. Endometrial biopsies were taken and total RNA extraction, cDNA synthesis and PCR was performed using 10 candidate HKG. The genes were arranged in terms of stability and normalisation was determined. Several HKGs not previously tested in endometrial samples were found to be more stable than those previously identified as the most stable. Of these, the 5 most stable HKG (in order of stability) were Prdm4 (PR domain 4) > Ube4a (Ubiquitin-Conjugating Enzyme 4a) > Enox2 (Ecto-NOX Disulfide-Thiol Exchanger 2) > Ube2d2 (Ubiquitin-conjugating enzyme E2D 2) > Actb (Actin beta). We therefore recommend using at least four of the aforementioned HKG for normalisation of endometrial tissues taken from patients with RM and RIF.

  8. Extracellular matrix and hormones transcriptionally regulate bovine. beta. -casein 5 prime sequences in stably transfected mouse mammary cells

    Energy Technology Data Exchange (ETDEWEB)

    Schmidhauser, C. Bissell, M.J. (Univ. of California, Berkeley (United States)); Myers, C.A.; Casperson, G.F. (Monsanto Corporate Research, St. Louis, MO (United States))

    1990-12-01

    Milk protein regulation involves synergistic action of lactogenic hormones and extracellular matrix (ECM). It is well established that substratum has a dramatic effect on morphology and function of mammary cells. The molecular mechanisms that regulate the ECM- and hormone-dependent gene expression, however, have not been resolved. To address this question, a subpopulation (designated CID 9) of the mouse mammary epithelial cell strain COMMA-2D has been developed in which more than 35% of the cells express {beta}-casein, form alveoli-like structures when plated onto a reconstituted basement membrane, and secrete {beta}-casein undirectionally into a lumen. These cells were stably transfected with a series of chloramphenicol acetyltransferase (CAT) fusion genes to study transcriptional regulation of the bovine {beta}-casein gene. The expression of CAT in these lines demonstrated a striking matrix and hormone dependency. This regulation occurered primarily at the transcriptional level and was dependent on the length of the 5{prime} flanking region of the {beta}-casein promotor. Both matrix and hormonal control of transcription occurred within at least the first 1790 base pairs upstream and/or 42 base pairs downstream of the transcriptional initiation site. The ECM effect was independent of glucocorticoid stimulation. However, prolactin was essential and hydrocortisone further increased CAT expression. Endogenous {beta}-casein expression in these lines was similar to that of the parent CID 9 cells. Our data indicate the existence of matrix-dependent elements that regulate transcription.

  9. Schroedinger fluid

    International Nuclear Information System (INIS)

    Kan, K.K.

    1983-01-01

    The relationship of nuclear internal flow and collective inertia, the difference of this flow from that of a classical fluid, and the approach of this flow to rigid flow in independent-particle model rotation are elucidated by reviewing the theory of Schroedinger fluid and its implications for collective vibration and rotation. (author)

  10. Fluid Dynamics

    DEFF Research Database (Denmark)

    Brorsen, Michael

    These lecture notes are intended mainly for the 7th semester course "Fluid Dynamics" offered by the Study Committee on Civil Engineering, Aalborg University.......These lecture notes are intended mainly for the 7th semester course "Fluid Dynamics" offered by the Study Committee on Civil Engineering, Aalborg University....

  11. Transition of Gas-Liquid Stratified Flow in Oil Transport Pipes

    Directory of Open Access Journals (Sweden)

    D. Lakehal

    2011-12-01

    Full Text Available Large-Scale Simulation results of the transition of a gas-liquid stratified flow to slug flow regime in circular 3D oil transport pipes under turbulent flow conditions expressed. Free surface flow in the pipe is treated using the Level Set method. Turbulence is approached via the LES and VLES methodologies extended to interfacial two-phase flows. It is shown that only with the Level Set method the flow transition can be accurately predicted, better than with the two-fluid phase-average model. The transition from stratified to slug flow is found to be subsequent to the merging of the secondary wave modes created by the action of gas shear (short waves with the first wave mode (high amplitude long wave. The model is capable of predicting global flow features like the onset of slugging and slug speed. In the second test case, the model predicts different kinds of slugs, the so-called operating slugs formed upstream that fill entirely the pipe with water slugs of length scales of the order of 2-4 D, and lower size (1-1.5 D disturbance slugs, featuring lower hold-up (0.8-0.9. The model predicts well the frequency of slugs. The simulations revealed important parameter effects on the results, such as two-dimensionality, pipe length, and water holdup.

  12. Stratified steady and unsteady two-phase flows between two parallel plates

    International Nuclear Information System (INIS)

    Sim, Woo Gun

    2006-01-01

    To understand fluid dynamic forces acting on a structure subjected to two-phase flow, it is essential to get detailed information about the characteristics of two-phase flow. Stratified steady and unsteady two-phase flows between two parallel plates have been studied to investigate the general characteristics of the flow related to flow-induced vibration. Based on the spectral collocation method, a numerical approach has been developed for the unsteady two-phase flow. The method is validated by comparing numerical result to analytical one given for a simple harmonic two-phase flow. The flow parameters for the steady two-phase flow, such as void fraction and two-phase frictional multiplier, are evaluated. The dynamic characteristics of the unsteady two-phase flow, including the void fraction effect on the complex unsteady pressure, are illustrated

  13. Analytical Simulation of Flow and Heat Transfer of Two-Phase Nanofluid (Stratified Flow Regime

    Directory of Open Access Journals (Sweden)

    Mohammad Abbasi

    2014-01-01

    Full Text Available Nanofluids have evoked immense interest from researchers all around the globe due to their numerous potential benefits and applications in important fields such as cooling electronic parts, cooling car engines and nuclear reactors. An analytical study of fluid flow of in-tube stratified regime of two-phase nanofluid has been carried out for CuO, Al2O2, TiO3, and Au as applied nanoparticles in water as the base liquid. Liquid film thickness, convective heat transfer coefficient, and dryout length have been calculated. Among the considered nano particles, Al2O3 and TiO2 because of providing more amounts of heat transfer along with longer lengths of dryout found as the most appropriate nanoparticles to achieve cooling objectives.

  14. Annual review of fluid mechanics. Volume 23

    International Nuclear Information System (INIS)

    Lumley, J.L.; Van Dyke, M.; Reed, H.L.

    1991-01-01

    Recent advances in theoretical, experimental, and computational fluid mechanics are discussed in a collection of annual review essays. Topics addressed include Lagrangian ocean studies, drag reduction in nature, the hydraulics of rotating strait and sill flow, analytical methods for the development of Reynolds-stress closures in turbulence, and exact solutions of the Navier-Stokes equations. Consideration is given to the theory of hurricanes, flow phenomena in CVD of thin films, particle-imaging techniques for experimental fluid mechanics, symmetry and symmetry-breaking bifurcations in fluid dynamics, turbulent mixing in stratified fluids, numerical simulation of transition in wall-bounded shear flows, fractals and multifractals in fluid turbulence, and coherent motions in the turbulent boundary layer

  15. A numerical study of laminar flames propagating in stratified mixtures

    Science.gov (United States)

    Zhang, Jiacheng

    Numerical simulations are carried out to study the structure and speed of laminar flames propagating in compositionally and thermally stratified fuel-air mixtures. The study is motivated by the need to understand the physics of flame propagation in stratified-charge engines and model it. The specific question of interest in this work is: how does the structure and speed of the flame in the stratified mixture differ from that of the flame in a corresponding homogeneous mixture at the same equivalence ratio, temperature, and pressure? The studies are carried out in hydrogen-air, methane-air, and n-heptane-air mixtures. A 30-species 184-step skeletal mechanism is employed for methane oxidation, a 9-species 21-step mechanism for hydrogen oxidation, and a 37-species 56-step skeletal mechanism for n-heptane oxidation. Flame speed and structure are compared with corresponding values for homogeneous mixtures. For compositionally stratified mixtures, as shown in prior experimental work, the numerical results suggest that when the flame propagates from a richer mixture to a leaner mixture, the flame speed is faster than the corresponding speed in the homogeneous mixture. This is caused by enhanced diffusion of heat and species from the richer mixture to the leaner mixture. In fact, the effects become more pronounced in leaner mixtures. Not surprisingly, the stratification gradient influences the results with shallower gradients showing less effect. The controlling role that diffusion plays is further assessed and confirmed by studying the effect of a unity Lewis number assumption in the hydrogen/air mixtures. Furthermore, the effect of stratification becomes less important when using methane or n-heptane as fuel. The laminar flame speed in a thermally stratified mixture is similar to the laminar flame speed in homogeneous mixture at corresponding unburned temperature. Theoretical analysis is performed and the ratio of extra thermal diffusion rate to flame heat release rate

  16. An analysis of the stratified and nonstartified flow transition criterion in horizontal/inclined pipes

    International Nuclear Information System (INIS)

    Sung, Chang Kyung

    1996-02-01

    The present studies are developed to present the two-step approach which is used in extending the phase-plane method and the hyperbolicity breaking concept for instability analyses of one-dimensional two-phase flow equations to the derivations of the new criterion for the stratified and non-stratified flow transition (e.g., onset of slugging), the critical flow condition criterion, and the flooding criterion. In the first step, more general forms for the onset of slugging criterion, the critical flow condition criterion, and the flooding criterion are derived based on the nonlinear analysis: more specifically, analyses of the phase-plane method and hyperbolicity breaking concept of the 'inflected nodes' (neutral stability conditions) and 'parallel lines' in the topological patterns of the linear system obtained from the transient one-dimensional two-phase flow equations of a two-fluid model. In the second step, through the introduction of simplifications and incorporation of a parameter (at the onset of slugging criterion) or an empirical constant (at the flooding criterion) into the general expression derived in the first step to satisfy a number of physical conditions a priori specified, new criteria for the onset of slugging and the onset of flooding have been derived. Validation of the present stratified and non-stratified flow transition criterion is achieved by comparison with the existing analytical criteria (Taitel and Dukler model and one-dimensional wave model) and experimental data from large test facilities (IFP, SINTEF, Harwell, Creare/PRC, ROSA and UPTF). The result of the validation shows good agreement at large pipe diameters and at high gas velocities. Present studies have revealed that the two-phase density ratio and pipe inclination angle are very important parameters that should be handled properly to determine the flow regime boundary correctly. Comparison between the present critical flow condition criterion with Gardner's critical flow

  17. A robust and accurate approach to computing compressible multiphase flow: Stratified flow model and AUSM+-up scheme

    International Nuclear Information System (INIS)

    Chang, Chih-Hao; Liou, Meng-Sing

    2007-01-01

    In this paper, we propose a new approach to compute compressible multifluid equations. Firstly, a single-pressure compressible multifluid model based on the stratified flow model is proposed. The stratified flow model, which defines different fluids in separated regions, is shown to be amenable to the finite volume method. We can apply the conservation law to each subregion and obtain a set of balance equations. Secondly, the AUSM + scheme, which is originally designed for the compressible gas flow, is extended to solve compressible liquid flows. By introducing additional dissipation terms into the numerical flux, the new scheme, called AUSM + -up, can be applied to both liquid and gas flows. Thirdly, the contribution to the numerical flux due to interactions between different phases is taken into account and solved by the exact Riemann solver. We will show that the proposed approach yields an accurate and robust method for computing compressible multiphase flows involving discontinuities, such as shock waves and fluid interfaces. Several one-dimensional test problems are used to demonstrate the capability of our method, including the Ransom's water faucet problem and the air-water shock tube problem. Finally, several two dimensional problems will show the capability to capture enormous details and complicated wave patterns in flows having large disparities in the fluid density and velocities, such as interactions between water shock wave and air bubble, between air shock wave and water column(s), and underwater explosion

  18. Construction of stably maintained non-mobilizable derivatives of RSF1010 lacking all known elements essential for mobilization

    Directory of Open Access Journals (Sweden)

    Tokmakova Irina L

    2007-11-01

    Full Text Available Abstract Background RSF1010 is a well-studied broad-host-range plasmid able to be mobilized to different bacteria and plants. RSF1010-derived plasmid vectors are widely used in both basic research and industrial applications. In the latter case, exploiting of mobilizable plasmids or even the plasmids possessing negligible mobilization frequency, but containing DNA fragments that could promote conjugal transfer, is undesirable because of biosafety considerations. Previously, several mutations significantly decreasing efficiency of RSF1010 mobilization have been selected. Nevertheless, construction of the RSF1010 derivative lacking all known loci involved in the conjugal transfer has not been reported yet. Results Novel non-mobilizable derivatives of RSF1010 lacking all known DNA sequences involved in the mobilization process have been obtained due to the exploiting of λRed-driven recombination between the plasmid and a constructed in vitro linear DNA fragment. To provide auto-regulated transcription of the essential replication gene, repB, the plasmid loci oriT, mobC and mobA were substituted by the DNA fragment containing PlacUV5→lacI. Mobilization of the obtained RSFmob plasmid was not detected in standard tests. The derivative of RSFmob with increased copy number has been obtained after lacI elimination. High stability of both constructed plasmids has been demonstrated in Escherichia coli and Pantoea ananatis. Design of RSFmob allows easy substitution of PlacUV5 by any desirable promoter for construction of novel derivatives with changed copy number or host range. Conclusion Novel non-mobilizable derivatives of RSF1010 lacking all known DNA sequences involved in the mobilization process and stably maintained at least in E. coli and P. ananatis have been constructed. The obtained plasmids became the progenitors of new cloning vectors answering all biosafety requirements of genetically modified organisms used in scale-up production.

  19. Generation and preclinical immunogenicity study of dengue type 2 virus-like particles derived from stably transfected mosquito cells.

    Science.gov (United States)

    Suphatrakul, Amporn; Yasanga, Thippawan; Keelapang, Poonsook; Sriburi, Rungtawan; Roytrakul, Thaneeya; Pulmanausahakul, Rojjanaporn; Utaipat, Utaiwan; Kawilapan, Yanee; Puttikhunt, Chunya; Kasinrerk, Watchara; Yoksan, Sutee; Auewarakul, Prasert; Malasit, Prida; Charoensri, Nicha; Sittisombut, Nopporn

    2015-10-13

    Recent phase IIb/III trials of a tetravalent live attenuated vaccine candidate revealed a need for improvement in the stimulation of protective immunity against diseases caused by dengue type 2 virus (DENV-2). Our attempts to develop particulate antigens for possibly supplementing live attenuated virus preparation involve generation and purification of recombinant DENV-2 virus-like particles (VLPs) derived from stably (prM+E)-expressing mosquito cells. Two VLP preparations generated with either negligible or enhanced prM cleavage exhibited different proportions of spherical particles and tubular particles of variable lengths. In BALB/c mice, VLPs were moderately immunogenic, requiring adjuvants for the induction of strong virus neutralizing antibody responses. VLPs with enhanced prM cleavage induced higher levels of neutralizing antibody than those without, but the stimulatory activity of both VLPs was similar in the presence of adjuvants. Comparison of EDIII-binding antibodies in mice following two adjuvanted doses of these VLPs revealed subtle differences in the stimulation of anti-EDIII binding antibodies. In cynomolgus macaques, VLPs with enhanced prM cleavage augmented strongly neutralizing antibody and EDIII-binding antibody responses in live attenuated virus-primed recipients, suggesting that these DENV-2 VLPs may be useful as the boosting antigen in prime-boost immunization. As the levels of neutralizing antibody induced in macaques with the prime-boost immunization were comparable to those infected with wild type virus, this virus-prime VLP-boost regimen may provide an immunization platform in which a need for robust neutralizing antibody response in the protection against DENV-2-associated illnesses could be tested. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.

    Directory of Open Access Journals (Sweden)

    Zhixin Lin

    Full Text Available The voltage dependent sodium channel Nav1.9, is expressed preferentially in peripheral sensory neurons and has been linked to human genetic pain disorders, which makes it target of interest for the development of new pain therapeutics. However, characterization of Nav1.9 pharmacology has been limited due in part to the historical difficulty of functionally expressing recombinant channels. Here we report the successful generation and characterization of human, mouse and rat Nav1.9 stably expressed in human HEK-293 cells. These cells exhibit slowly activating and inactivating inward sodium channel currents that have characteristics of native Nav1.9. Optimal functional expression was achieved by coexpression of Nav1.9 with β1/β2 subunits. While recombinantly expressed Nav1.9 was found to be sensitive to sodium channel inhibitors TC-N 1752 and tetracaine, potency was up to 100-fold less than reported for other Nav channel subtypes despite evidence to support an interaction with the canonical local anesthetic (LA binding region on Domain 4 S6. Nav1.9 Domain 2 S6 pore domain contains a unique lysine residue (K799 which is predicted to be spatially near the local anesthetic interaction site. Mutation of this residue to the consensus asparagine (K799N resulted in an increase in potency for tetracaine, but a decrease for TC-N 1752, suggesting that this residue can influence interaction of inhibitors with the Nav1.9 pore. In summary, we have shown that stable functional expression of Nav1.9 in the widely used HEK-293 cells is possible, which opens up opportunities to better understand channel properties and may potentially aid identification of novel Nav1.9 based pharmacotherapies.

  1. Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization

    International Nuclear Information System (INIS)

    Hashiguchi, Kohtaro; Ozaki, Masumi; Kuraoka, Isao; Saitoh, Hisato

    2013-01-01

    Highlights: ► A human cell line expressing a mouse Nip45 has facilitated Nip45 analysis. ► Nip45 does not effectively inhibit polySUMOylation in vivo. ► Nip45 interacts directly with SUMO and SUMO chains. ► Nip45 accumulates at PML bodies in response to proteasome inhibition. -- Abstract: The nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein, Nfatc2ip (Nip45), has been implicated as a crucial coordinator of the immune response and of cellular differentiation in humans and mice, and contains SUMO-like domains in its C-terminal region. However, the significance of its N-terminal region and its correlation to the SUMO modification pathway remain largely uncharacterized. In this study, a human cultured cell line was established, in which FLAG-tagged mouse Nip45 (FLAG-mNip45) was stably overexpressed. Under standard, non-stressful conditions, we detected FLAG-mNip45 diffusely distributed in the nucleus. Intriguingly, proteasome inhibition by MG132 caused FLAG-mNip45, together with SUMOylated proteins, to localize in nuclear domains associated with promyelocytic leukemia protein. Finally, using an in vitro binding assay, we showed interaction of the N-terminal region of mNip45 with both free SUMO-3 and SUMO-3 chains, indicating that Nip45 may, in part, exert its function via interaction with SUMO/SUMOylated proteins. Taken together, our study provides novel information on a poorly characterized mammalian protein and suggests that our newly established cell line will be useful for elucidating the physiological role of Nip45.

  2. Hydrodynamic 'memory' of binary fluid mixtures

    International Nuclear Information System (INIS)

    Kalashnik, M. V.; Ingel, L. Kh.

    2006-01-01

    A theoretical analysis is presented of hydrostatic adjustment in a two-component fluid system, such as seawater stratified with respect to temperature and salinity. Both linear approximation and nonlinear problem are investigated. It is shown that scenarios of relaxation to a hydrostatically balanced state in binary fluid mixtures may substantially differ from hydrostatic adjustment in fluids that can be stratified only with respect to temperature. In particular, inviscid two-component fluids have 'memory': a horizontally nonuniform disturbance in the initial temperature or salinity distribution does not vanish even at the final stage, transforming into a persistent thermohaline 'trace.' Despite stability of density stratification and convective stability of the fluid system by all known criteria, an initial temperature disturbance may not decay and may even increase in amplitude. Moreover, its sign may change (depending on the relative contributions of temperature and salinity to stable background density stratification). Hydrostatic adjustment may involve development of discontinuous distributions from smooth initial temperature or concentration distributions. These properties of two-component fluids explain, in particular, the occurrence of persistent horizontally or vertically nonuniform temperature and salinity distributions in the ocean, including discontinuous ones

  3. Analysis of photonic band-gap structures in stratified medium

    DEFF Research Database (Denmark)

    Tong, Ming-Sze; Yinchao, Chen; Lu, Yilong

    2005-01-01

    Purpose - To demonstrate the flexibility and advantages of a non-uniform pseudo-spectral time domain (nu-PSTD) method through studies of the wave propagation characteristics on photonic band-gap (PBG) structures in stratified medium Design/methodology/approach - A nu-PSTD method is proposed...... in solving the Maxwell's equations numerically. It expands the temporal derivatives using the finite differences, while it adopts the Fourier transform (FT) properties to expand the spatial derivatives in Maxwell's equations. In addition, the method makes use of the chain-rule property in calculus together...... with the transformed space technique in order to make the algorithm flexible in terms of non-uniform spatial sampling. Findings - Through the studies of the wave propagation characteristics on PBG structures in stratified medium, it has been found that the proposed method retains excellent accuracy in the occasions...

  4. Identification of major planktonic sulfur oxidizers in stratified freshwater lake.

    Directory of Open Access Journals (Sweden)

    Hisaya Kojima

    Full Text Available Planktonic sulfur oxidizers are important constituents of ecosystems in stratified water bodies, and contribute to sulfide detoxification. In contrast to marine environments, taxonomic identities of major planktonic sulfur oxidizers in freshwater lakes still remain largely unknown. Bacterioplankton community structure was analyzed in a stratified freshwater lake, Lake Mizugaki in Japan. In the clone libraries of 16S rRNA gene, clones very closely related to a sulfur oxidizer isolated from this lake, Sulfuritalea hydrogenivorans, were detected in deep anoxic water, and occupied up to 12.5% in each library of different water depth. Assemblages of planktonic sulfur oxidizers were specifically analyzed by constructing clone libraries of genes involved in sulfur oxidation, aprA, dsrA, soxB and sqr. In the libraries, clones related to betaproteobacteria were detected with high frequencies, including the close relatives of Sulfuritalea hydrogenivorans.

  5. Insight into steam explosion in stratified melt-coolant configuration

    OpenAIRE

    Grishchenko, Dmitry; Konovalenko, Alexander; Karbojian, Aram; Kudinova, Valtyna; Bechta, Sevostian; Kudinov, Pavel

    2013-01-01

    Release of core melt from failed reactor vessel into a pool of water is adopted in several existing designs of light water reactors (LWRs) as an element of severe accident  mitigation  strategy.  When  vessel  breach  is  large  and  water  pool  is shallow,  released  corium  melt  can  reach  containment  floor  in  liquid  form  and spread under water creating a stratified configuration of melt covered by coolant. Steam  explosion  in  such  stratified  configuration  was  long  believed  ...

  6. Dust particle charge distribution in a stratified glow discharge

    Energy Technology Data Exchange (ETDEWEB)

    Sukhinin, Gennady I [Institute of Thermophysics, Siberian Branch, Russian Academy of Sciences, Lavrentyev Ave., 1, Novosibirsk 630090 (Russian Federation); Fedoseev, Alexander V [Institute of Thermophysics, Siberian Branch, Russian Academy of Sciences, Lavrentyev Ave., 1, Novosibirsk 630090 (Russian Federation); Ramazanov, Tlekkabul S [Institute of Experimental and Theoretical Physics, Al Farabi Kazakh National University, Tole Bi, 96a, Almaty 050012 (Kazakhstan); Dzhumagulova, Karlygash N [Institute of Experimental and Theoretical Physics, Al Farabi Kazakh National University, Tole Bi, 96a, Almaty 050012 (Kazakhstan); Amangaliyeva, Rauan Zh [Institute of Experimental and Theoretical Physics, Al Farabi Kazakh National University, Tole Bi, 96a, Almaty 050012 (Kazakhstan)

    2007-12-21

    The influence of a highly pronounced non-equilibrium characteristic of the electron energy distribution function in a stratified dc glow discharge on the process of dust particle charging in a complex plasma is taken into account for the first time. The calculated particle charge spatial distribution is essentially non-homogeneous and it can explain the vortex motion of particles at the periphery of a dusty cloud obtained in experiments.

  7. Indications for tonsillectomy stratified by the level of evidence

    OpenAIRE

    Windfuhr, Jochen P.

    2016-01-01

    Background: One of the most significant clinical trials, demonstrating the efficacy of tonsillectomy (TE) for recurrent throat infection in severely affected children, was published in 1984. This systematic review was undertaken to compile various indications for TE as suggested in the literature after 1984 and to stratify the papers according to the current concept of evidence-based medicine.Material and methods: A systematic Medline research was performed using the key word of "tonsillect...

  8. Economic Evaluation in Stratified Medicine: Methodological Issues and Challenges

    OpenAIRE

    Fugel, Hans-Joerg; Nuijten, Mark; Postma, Maarten; Redekop, Ken

    2016-01-01

    textabstractBackground: Stratified Medicine (SM) is becoming a practical reality with the targeting of medicines by using a biomarker or genetic-based diagnostic to identify the eligible patient sub-population. Like any healthcare intervention, SM interventions have costs and consequences that must be considered by reimbursement authorities with limited resources. Methodological standards and guidelines exist for economic evaluations in clinical pharmacology and are an important component for...

  9. Community genomics among stratified microbial assemblages in the ocean's interior

    DEFF Research Database (Denmark)

    DeLong, Edward F; Preston, Christina M; Mincer, Tracy

    2006-01-01

    Microbial life predominates in the ocean, yet little is known about its genomic variability, especially along the depth continuum. We report here genomic analyses of planktonic microbial communities in the North Pacific Subtropical Gyre, from the ocean's surface to near-sea floor depths. Sequence......, and host-viral interactions. Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics....

  10. Fundamental Processes of Atomization in Fluid-Fluid Flows

    Science.gov (United States)

    McCready, M. J.; Chang, H.-C.; Leighton, D. T.

    2001-01-01

    This report outlines the major results of the grant "Fundamental Processes of Atomization in Fluid-Fluid Flows." These include: 1) the demonstration that atomization in liquid/liquid shear flow is driven by a viscous shear instability that triggers the formation of a long thin sheet; 2) discovery of a new mode of interfacial instability for oscillatory two-layer systems whereby a mode that originates within the less viscous liquid phase causes interfacial deformation as the oscillation proceeds; 3) the demonstration that rivulet formation from gravity front occurs because the local front shape specified by gravity and surface tension changes from a nose to a wedge geometry, thus triggering a large increase in viscous resistance; and 4) extension of the studies on nonlinear wave evolution on falling films and in stratified flow, particularly the evolution towards large-amplitude solitary waves that tend to generate drops.

  11. Background stratified Poisson regression analysis of cohort data.

    Science.gov (United States)

    Richardson, David B; Langholz, Bryan

    2012-03-01

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models.

  12. Background stratified Poisson regression analysis of cohort data

    International Nuclear Information System (INIS)

    Richardson, David B.; Langholz, Bryan

    2012-01-01

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models. (orig.)

  13. Background stratified Poisson regression analysis of cohort data

    Energy Technology Data Exchange (ETDEWEB)

    Richardson, David B. [University of North Carolina at Chapel Hill, Department of Epidemiology, School of Public Health, Chapel Hill, NC (United States); Langholz, Bryan [Keck School of Medicine, University of Southern California, Division of Biostatistics, Department of Preventive Medicine, Los Angeles, CA (United States)

    2012-03-15

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models. (orig.)

  14. Thermo-diffusion effect on free convection heat and mass transfer in a thermally linearly stratified non-darcy porous media

    KAUST Repository

    Murthy, P.V.S.N.

    2011-12-26

    Thermo-diffusion effect on free convection heat and mass transfer from a vertical surface embedded in a liquid saturated thermally stratified non - Darcy porous medium has been analyzed using a local non-similar procedure. The wall temperature and concentration are constant and the medium is linearly stratified in the vertical direction with respect to the thermal conditions. The fluid flow, temperature and concentration fields are affected by the complex interactions among the diffusion ratio Le, buoyancy ratio N, thermo-diffusion parameter Sr and stratification parameter ?. Non-linear interactions of all these parameters on the convective transport has been analyzed and variation of heat and mass transfer coefficients with thermo-diffusion parameter in the thermally stratified non-Darcy porous media is presented through computer generated plots.

  15. CFD Code Validation against Stratified Air-Water Flow Experimental Data

    Directory of Open Access Journals (Sweden)

    F. Terzuoli

    2008-01-01

    Full Text Available Pressurized thermal shock (PTS modelling has been identified as one of the most important industrial needs related to nuclear reactor safety. A severe PTS scenario limiting the reactor pressure vessel (RPV lifetime is the cold water emergency core cooling (ECC injection into the cold leg during a loss of coolant accident (LOCA. Since it represents a big challenge for numerical simulations, this scenario was selected within the European Platform for Nuclear Reactor Simulations (NURESIM Integrated Project as a reference two-phase problem for computational fluid dynamics (CFDs code validation. This paper presents a CFD analysis of a stratified air-water flow experimental investigation performed at the Institut de Mécanique des Fluides de Toulouse in 1985, which shares some common physical features with the ECC injection in PWR cold leg. Numerical simulations have been carried out with two commercial codes (Fluent and Ansys CFX, and a research code (NEPTUNE CFD. The aim of this work, carried out at the University of Pisa within the NURESIM IP, is to validate the free surface flow model implemented in the codes against experimental data, and to perform code-to-code benchmarking. Obtained results suggest the relevance of three-dimensional effects and stress the importance of a suitable interface drag modelling.

  16. Regressed relations for forced convection heat transfer in a direct injection stratified charge rotary engine

    Science.gov (United States)

    Lee, Chi M.; Schock, Harold J.

    1988-01-01

    Currently, the heat transfer equation used in the rotary combustion engine (RCE) simulation model is taken from piston engine studies. These relations have been empirically developed by the experimental input coming from piston engines whose geometry differs considerably from that of the RCE. The objective of this work was to derive equations to estimate heat transfer coefficients in the combustion chamber of an RCE. This was accomplished by making detailed temperature and pressure measurements in a direct injection stratified charge (DISC) RCE under a range of conditions. For each specific measurement point, the local gas velocity was assumed equal to the local rotor tip speed. Local physical properties of the fluids were then calculated. Two types of correlation equations were derived and are described in this paper. The first correlation expresses the Nusselt number as a function of the Prandtl number, Reynolds number, and characteristic temperature ratio; the second correlation expresses the forced convection heat transfer coefficient as a function of fluid temperature, pressure and velocity.

  17. Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor

    DEFF Research Database (Denmark)

    Pedersen, U B; Norby, B; Jensen, Anders A.

    1994-01-01

    Human dopamine D1a and D1b receptors were stably expressed in Baby Hamster Kidney (BHK) or Chinese Hamster Ovary (CHO) cells. [3H]SCH23390 saturation experiments indicated the presence of only a single binding site in the D1a expressing cell line with a Kd of 0.5 nM. In D1b expressing cell lines...

  18. E25 stratified torch ignition engine emissions and combustion analysis

    International Nuclear Information System (INIS)

    Rodrigues Filho, Fernando Antonio; Baêta, José Guilherme Coelho; Teixeira, Alysson Fernandes; Valle, Ramón Molina; Fonseca de Souza, José Leôncio

    2016-01-01

    Highlights: • A stratified torch ignition (STI) engine was built and tested. • The STI engines was tested in a wide range of load and speed. • Significant reduction on emissions was achieved by means of the STI system. • Low cyclic variability characterized the lean combustion process of the torch ignition engine. • HC emission is the main drawback of the stratified torch ignition engine. - Abstract: Vehicular emissions significantly increase atmospheric air pollution and greenhouse gases (GHG). This fact associated with fast global vehicle fleet growth calls for prompt scientific community technological solutions in order to promote a significant reduction in vehicle fuel consumption and emissions, especially of fossil fuels to comply with future legislation. To meet this goal, a prototype stratified torch ignition (STI) engine was built from a commercial existing baseline engine. In this system, combustion starts in a pre-combustion chamber, where the pressure increase pushes the combustion jet flames through calibrated nozzles to be precisely targeted into the main chamber. These combustion jet flames are endowed with high thermal and kinetic energy, being able to generate a stable lean combustion process. The high kinetic and thermal energy of the combustion jet flame results from the load stratification. This is carried out through direct fuel injection in the pre-combustion chamber by means of a prototype gasoline direct injector (GDI) developed for a very low fuel flow rate. In this work the engine out-emissions of CO, NOx, HC and CO 2 of the STI engine are presented and a detailed analysis supported by the combustion parameters is conducted. The results obtained in this work show a significant decrease in the specific emissions of CO, NOx and CO 2 of the STI engine in comparison with the baseline engine. On the other hand, HC specific emission increased due to wall wetting from the fuel hitting in the pre-combustion chamber wall.

  19. Photonic Bandgaps in Mie Scattering by Concentrically Stratified Spheres

    Science.gov (United States)

    Smith, David D.; Fuller, Kirk A.; Curreri, Peter A.

    2002-01-01

    The Mie formulation for homogeneous spheres is generalized to handle core/shell systems and multiple concentric layers in a manner that exploits an analogy with stratified planar systems, thereby allowing concentric multi-layered structures to be treated as photonic bandgap materials. Representative results from a Mie code employing this analogy demonstrate that photonic bands are present for periodic concentric spheres, though not readily apparent in extinction spectra. Rather, the periodicity simply alters the scattering profile, enhancing the ratio of backscattering to forward scattering inside the bandgap, whereas modification of the interference structure is evident in extinction spectra in accordance with the optical theorem

  20. Analysis of photonic band-gap structures in stratified medium

    DEFF Research Database (Denmark)

    Tong, Ming-Sze; Yinchao, Chen; Lu, Yilong

    2005-01-01

    in solving the Maxwell's equations numerically. It expands the temporal derivatives using the finite differences, while it adopts the Fourier transform (FT) properties to expand the spatial derivatives in Maxwell's equations. In addition, the method makes use of the chain-rule property in calculus together...... in electromagnetic and microwave applications once the Maxwell's equations are appropriately modeled. Originality/value - The method validates its values and properties through extensive studies on regular and defective 1D PBG structures in stratified medium, and it can be further extended to solving more...

  1. Electromagnetic fields due to dipole antennas over stratified anisotropic media.

    Science.gov (United States)

    Kong, J. A.

    1972-01-01

    Solutions to the problem of radiation of dipole antennas in the presence of a stratified anisotropic media are facilitated by decomposing a general wave field into transverse magnetic (TM) and transverse electric (TE) modes. Employing the propagation matrices, wave amplitudes in any region are related to those in any other regions. The reflection coefficients, which embed all the information about the geometrical configuration and the physical constituents of the medium, are obtained in closed form. In view of the general formulation, various special cases are discussed.

  2. Stratifying patients with peripheral neuropathic pain based on sensory profiles

    DEFF Research Database (Denmark)

    Vollert, Jan; Maier, Christoph; Attal, Nadine

    2017-01-01

    In a recent cluster analysis, it has been shown that patients with peripheral neuropathic pain can be grouped into 3 sensory phenotypes based on quantitative sensory testing profiles, which are mainly characterized by either sensory loss, intact sensory function and mild thermal hyperalgesia and...... populations that need to be screened to reach a subpopulation large enough to conduct a phenotype-stratified study. The most common phenotype in diabetic polyneuropathy was sensory loss (83%), followed by mechanical hyperalgesia (75%) and thermal hyperalgesia (34%, note that percentages are overlapping...

  3. Fluid Shifts

    Science.gov (United States)

    Stenger, M. B.; Hargens, A. R.; Dulchavsky, S. A.; Arbeille, P.; Danielson, R. W.; Ebert, D. J.; Garcia, K. M.; Johnston, S. L.; Laurie, S. S.; Lee, S. M. C.; hide

    2017-01-01

    Introduction. NASA's Human Research Program is focused on addressing health risks associated with long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but now more than 50 percent of ISS astronauts have experienced more profound, chronic changes with objective structural findings such as optic disc edema, globe flattening and choroidal folds. These structural and functional changes are referred to as the visual impairment and intracranial pressure (VIIP) syndrome. Development of VIIP symptoms may be related to elevated intracranial pressure (ICP) secondary to spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight and to determine if a relation exists with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as any VIIP-related effects of those shifts, are predicted by the crewmember's pre-flight status and responses to acute hemodynamic manipulations, specifically posture changes and lower body negative pressure. Methods. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, and calcaneus tissue thickness (by ultrasound); (3) vascular dimensions by ultrasound (jugular veins, cerebral and carotid arteries, vertebral arteries and veins, portal vein); (4) vascular dynamics by MRI (head/neck blood flow, cerebrospinal fluid

  4. Sensitivity and inversion of full seismic waveforms in stratified porous medium

    International Nuclear Information System (INIS)

    Barros, L. de

    2007-12-01

    Characterization of porous media parameters, and particularly the porosity, permeability and fluid properties are very useful in many applications (hydrologic, natural hazards or oil industry). The aim of my research is to evaluate the possibility to determine these properties from the full seismic wave fields. First, I am interested in the useful parameters and the specific properties of the seismic waves in the poro-elastic theory, often called Biot (1956) theory. I then compute seismic waves propagation in fluid saturated stratified porous media with a reflectivity method coupled with the discrete wavenumber integration method. I first used this modeling to study the possibilities to determine the carbon dioxide concentration and localization thanks to the reflected P-waves in the case of the deep geological storage of Sleipner (North Sea). The sensitivity of the seismic response to the poro-elastic parameters are then generalized by the analytical computation of the Frechet derivatives which are expressed in terms of the Green's functions of the unperturbed medium. The numerical tests show that the porosity and the consolidation are the main parameters to invert. The sensitivity operators are then introduced in a inversion algorithm based on iterative modeling of the full waveform. The classical algorithm of generalized least-square inverse problem is solved by the quasi-Newton technique (Tarantola, 1984). The inversion of synthetic data show that we can invert for the porosity and the fluid and solid parameters (densities and mechanical modulus, or volume rate of fluid and mineral) can be correctly rebuilt if the other parameters are well known. However, the strong seismic coupling of the porous parameters leads to difficulties to invert simultaneously for several parameters. One way to get round these difficulties is to use additional information and invert for one single parameter for the fluid properties (saturating rate) or for the lithology. An other way

  5. Random forcing of geostrophic motion in rotating stratified turbulence

    Science.gov (United States)

    Waite, Michael L.

    2017-12-01

    Random forcing of geostrophic motion is a common approach in idealized simulations of rotating stratified turbulence. Such forcing represents the injection of energy into large-scale balanced motion, and the resulting breakdown of quasi-geostrophic turbulence into inertia-gravity waves and stratified turbulence can shed light on the turbulent cascade processes of the atmospheric mesoscale. White noise forcing is commonly employed, which excites all frequencies equally, including frequencies much higher than the natural frequencies of large-scale vortices. In this paper, the effects of these high frequencies in the forcing are investigated. Geostrophic motion is randomly forced with red noise over a range of decorrelation time scales τ, from a few time steps to twice the large-scale vortex time scale. It is found that short τ (i.e., nearly white noise) results in about 46% more gravity wave energy than longer τ, despite the fact that waves are not directly forced. We argue that this effect is due to wave-vortex interactions, through which the high frequencies in the forcing are able to excite waves at their natural frequencies. It is concluded that white noise forcing should be avoided, even if it is only applied to the geostrophic motion, when a careful investigation of spontaneous wave generation is needed.

  6. Analysis of a global random stratified sample of nurse legislation.

    Science.gov (United States)

    Benton, D C; Fernández-Fernández, M P; González-Jurado, M A; Beneit-Montesinos, J V

    2015-06-01

    To identify, compare and contrast the major component parts of heterogeneous stratified sample of nursing legislation. Nursing legislation varies from one jurisdiction to another. Up until now no research exists into whether the variations of such legislation are random or if variations are related to a set of key attributes. This mixed method study used a random stratified sample of legislation to map through documentary analysis the content of 14 nursing acts and then explored, using quantitative techniques, whether the material contained relates to a number of key attributes. These attributes include: legal tradition of the jurisdiction; model of regulation; administrative approach; area of the world; and the economic status of the jurisdiction. Twelve component parts of nursing legislation were identified. These were remarkably similar irrespective of attributes of interest. However, not all component parts were specified in the same level of detail and the manner by which the elements were addressed did vary. A number of potential relationships between the structure of the legislation and the key attributes of interest were identified. This study generated a comprehensive and integrated map of a global sample of nursing legislation. It provides a set of descriptors to be used to undertake further quantitative work and provides an important policy tool to facilitate dialogue between regulatory bodies. At the individual nurse level it offers insights that can help nurses pursue recognition of credentials across jurisdictions. © 2015 International Council of Nurses.

  7. Efficient Radiative Transfer for Dynamically Evolving Stratified Atmospheres

    Science.gov (United States)

    Judge, Philip G.

    2017-12-01

    We present a fast multi-level and multi-atom non-local thermodynamic equilibrium radiative transfer method for dynamically evolving stratified atmospheres, such as the solar atmosphere. The preconditioning method of Rybicki & Hummer (RH92) is adopted. But, pressed for the need of speed and stability, a “second-order escape probability” scheme is implemented within the framework of the RH92 method, in which frequency- and angle-integrals are carried out analytically. While minimizing the computational work needed, this comes at the expense of numerical accuracy. The iteration scheme is local, the formal solutions for the intensities are the only non-local component. At present the methods have been coded for vertical transport, applicable to atmospheres that are highly stratified. The probabilistic method seems adequately fast, stable, and sufficiently accurate for exploring dynamical interactions between the evolving MHD atmosphere and radiation using current computer hardware. Current 2D and 3D dynamics codes do not include this interaction as consistently as the current method does. The solutions generated may ultimately serve as initial conditions for dynamical calculations including full 3D radiative transfer. The National Center for Atmospheric Research is sponsored by the National Science Foundation.

  8. Wave modes in magnetic elements in a stratified atmosphere

    International Nuclear Information System (INIS)

    Wilson, P.R.

    1978-01-01

    The vibration modes of a magnetic flux element embedded in a compressible, gravitationally stratified atmosphere are considered. A local dispersion relation is first derived for a force-free field which decreases exponentially with height, and this is applied to a magnetic flux sheath lying within the local region. The sheath is embedded in an isothermal, gravitationally stratified plasma for which the standard dispersion relation applies globally.The velocity and pressure balance conditions across the interface restrict the possible vibration modes of the system. For the pulsation or varicose mode, a modified acoustic mode and a modified fast mode are obtained. The latter has a cutoff frequency which is greater than the acoustic cutoff and suggests that waves of shorter periods may occur in the presence of magnetic elements.For the sinuous or taut wire mode, complex solutions for the dispersion equation are obtained. For one of these the real part is large and negative, indicating that, within the limitations of a linear analysis, waves propagate with increasing amplitude. The possible significance of this is briefly discussed

  9. Designing Wood Supply Scenarios from Forest Inventories with Stratified Predictions

    Directory of Open Access Journals (Sweden)

    Philipp Kilham

    2018-02-01

    Full Text Available Forest growth and wood supply projections are increasingly used to estimate the future availability of woody biomass and the correlated effects on forests and climate. This research parameterizes an inventory-based business-as-usual wood supply scenario, with a focus on southwest Germany and the period 2002–2012 with a stratified prediction. First, the Classification and Regression Trees algorithm groups the inventory plots into strata with corresponding harvest probabilities. Second, Random Forest algorithms generate individual harvest probabilities for the plots of each stratum. Third, the plots with the highest individual probabilities are selected as harvested until the harvest probability of the stratum is fulfilled. Fourth, the harvested volume of these plots is predicted with a linear regression model trained on harvested plots only. To illustrate the pros and cons of this method, it is compared to a direct harvested volume prediction with linear regression, and a combination of logistic regression and linear regression. Direct harvested volume regression predicts comparable volume figures, but generates these volumes in a way that differs from business-as-usual. The logistic model achieves higher overall classification accuracies, but results in underestimations or overestimations of harvest shares for several subsets of the data. The stratified prediction method balances this shortcoming, and can be of general use for forest growth and timber supply projections from large-scale forest inventories.

  10. Beyond Genetics—Stratified and Personalised Medicines Using Multiple Parameters

    Directory of Open Access Journals (Sweden)

    Richard Peck

    2010-05-01

    Full Text Available Prescribers have been practicing stratified medicine for many years. Patient characteristics, usually non-genetic, including age, comorbidities and concomitant medications are taken into account when deciding which drug to prescribe. In addition, the majority of drugs require dose adjustments across patient subgroups, usually determined by non-genetic differences between the subgroups. Whilst pharmacogenetics hold promise for enhancing treatment stratification and even treatment individualisation, non-genetic factors will continue to be very important. Both non-genetic and genetic factors must be considered to improve understanding and quantification of the variability in treatment outcomes and to guide stratification and targeting of patient subgroups to the right drug and also to the right range of doses within that subgroup. Development of stratified medicines must consider non-genetic as well as genetic factors and, where appropriate, include stratification through optimising the dose for each patient or subgroup as well as by choosing the drug most likely to deliver efficacy to that patient or group.

  11. Crystallization of a compositionally stratified basal magma ocean

    Science.gov (United States)

    Laneuville, Matthieu; Hernlund, John; Labrosse, Stéphane; Guttenberg, Nicholas

    2018-03-01

    Earth's ∼3.45 billion year old magnetic field is regenerated by dynamo action in its convecting liquid metal outer core. However, convection induces an isentropic thermal gradient which, coupled with a high core thermal conductivity, results in rapid conducted heat loss. In the absence of implausibly high radioactivity or alternate sources of motion to drive the geodynamo, the Earth's early core had to be significantly hotter than the melting point of the lower mantle. While the existence of a dense convecting basal magma ocean (BMO) has been proposed to account for high early core temperatures, the requisite physical and chemical properties for a BMO remain controversial. Here we relax the assumption of a well-mixed convecting BMO and instead consider a BMO that is initially gravitationally stratified owing to processes such as mixing between metals and silicates at high temperatures in the core-mantle boundary region during Earth's accretion. Using coupled models of crystallization and heat transfer through a stratified BMO, we show that very high temperatures could have been trapped inside the early core, sequestering enough heat energy to run an ancient geodynamo on cooling power alone.

  12. A modified stratified model for the 3C 273 jet

    International Nuclear Information System (INIS)

    Liu Wenpo; Shen Zhiqiang

    2009-01-01

    We present a modified stratified jet model to interpret the observed spectral energy distributions of knots in the 3C 273 jet. Based on the hypothesis of the single index of the particle energy spectrum at injection and identical emission processes among all the knots, the observed difference of spectral shape among different 3C 273 knots can be understood as a manifestation of the deviation of the equivalent Doppler factor of stratified emission regions in an individual knot from a characteristic one. The summed spectral energy distributions of all ten knots in the 3C 273 jet can be well fitted by two components: a low-energy component (radio to optical) dominated by synchrotron radiation and a high-energy component (UV, X-ray and γ-ray) dominated by inverse Compton scattering of the cosmic microwave background. This gives a consistent spectral index of α = 0.88 (S v ∝ v -α ) and a characteristic Doppler factor of 7.4. Assuming the average of the summed spectrum as the characteristic spectrum of each knot in the 3C 273 jet, we further get a distribution of Doppler factors. We discuss the possible implications of these results for the physical properties in the 3C 273 jet. Future GeV observations with GLAST could separate the γ-ray emission of 3C 273 from the large scale jet and the small scale jet (i.e. the core) through measuring the GeV spectrum.

  13. STRESS DISTRIBUTION IN THE STRATIFIED MASS CONTAINING VERTICAL ALVEOLE

    Directory of Open Access Journals (Sweden)

    Bobileva Tatiana Nikolaevna

    2017-08-01

    Full Text Available Almost all subsurface rocks used as foundations for various types of structures are stratified. Such heterogeneity may cause specific behaviour of the materials under strain. Differential equations describing the behaviour of such materials contain rapidly fluctuating coefficients, in view of this, solution of such equations is more time-consuming when using today’s computers. The method of asymptotic averaging leads to getting homogeneous medium under study to averaged equations with fixed factors. The present article is concerned with stratified soil mass consisting of pair-wise alternative isotropic elastic layers. In the results of elastic modules averaging, the present soil mass with horizontal rock stratification is simulated by homogeneous transversal-isotropic half-space with isotropy plane perpendicular to the standing axis. Half-space is loosened by a vertical alveole of circular cross-section, and virgin ground is under its own weight. For horizontal parting planes of layers, the following two types of surface conditions are set: ideal contact and backlash without cleavage. For homogeneous transversal-isotropic half-space received with a vertical alveole, the analytical solution of S.G. Lekhnitsky, well known in scientific papers, is used. The author gives expressions for stress components and displacements in soil mass for different marginal conditions on the alveole surface. Such research problems arise when constructing and maintaining buildings and when composite materials are used.

  14. Energetics of stratified turbulent mixing at geophysical scales

    Science.gov (United States)

    Scotti, Alberto; Passaggia, Pierre-Yves; White, Brian

    2017-11-01

    Energy-based arguments provide a fundamental diagnostic tool in turbulent flows. In stratified incompressible flows, there are two reservoirs of energy, the kinetic and potential energy. However, the standard expression Ep = ρgZ for the latter is not convex, and thus, within an energetic framework based on this definition, turbulent fluctuations have zero potential energy, a rather unsatisfactorily state of affairs. The solution is to modify the definition of potential energy to include only the portion that is effectively available. This introduces the concept of Available Potential Energy (APE). In this talk, we approach the problem of APE using a general framework which recovers the standard buoyancy-only dependent formulation in non-rotating systems. Unlike the standard formulation, rotation can be included in a natural way, in which case the Available Energy depends both on the buoyancy and potential vorticity distribution. We will show results from experiments of stratified mixing at oceanic values of the Gibson number conducted in our large flume. The goal of this experiments is to shed some light on the controversy surrounding the relationship between the mixing efficiency and the Gibson number. Funded by NSF-OCE-1155558 and OCE-1736989.

  15. Crenothrix are major methane consumers in stratified lakes.

    Science.gov (United States)

    Oswald, Kirsten; Graf, Jon S; Littmann, Sten; Tienken, Daniela; Brand, Andreas; Wehrli, Bernhard; Albertsen, Mads; Daims, Holger; Wagner, Michael; Kuypers, Marcel Mm; Schubert, Carsten J; Milucka, Jana

    2017-09-01

    Methane-oxidizing bacteria represent a major biological sink for methane and are thus Earth's natural protection against this potent greenhouse gas. Here we show that in two stratified freshwater lakes a substantial part of upward-diffusing methane was oxidized by filamentous gamma-proteobacteria related to Crenothrix polyspora. These filamentous bacteria have been known as contaminants of drinking water supplies since 1870, but their role in the environmental methane removal has remained unclear. While oxidizing methane, these organisms were assigned an 'unusual' methane monooxygenase (MMO), which was only distantly related to 'classical' MMO of gamma-proteobacterial methanotrophs. We now correct this assignment and show that Crenothrix encode a typical gamma-proteobacterial PmoA. Stable isotope labeling in combination swith single-cell imaging mass spectrometry revealed methane-dependent growth of the lacustrine Crenothrix with oxygen as well as under oxygen-deficient conditions. Crenothrix genomes encoded pathways for the respiration of oxygen as well as for the reduction of nitrate to N 2 O. The observed abundance and planktonic growth of Crenothrix suggest that these methanotrophs can act as a relevant biological sink for methane in stratified lakes and should be considered in the context of environmental removal of methane.

  16. Measuring mixing efficiency in experiments of strongly stratified turbulence

    Science.gov (United States)

    Augier, P.; Campagne, A.; Valran, T.; Calpe Linares, M.; Mohanan, A. V.; Micard, D.; Viboud, S.; Segalini, A.; Mordant, N.; Sommeria, J.; Lindborg, E.

    2017-12-01

    Oceanic and atmospheric models need better parameterization of the mixing efficiency. Therefore, we need to measure this quantity for flows representative of geophysical flows, both in terms of types of flows (with vortices and/or waves) and of dynamical regimes. In order to reach sufficiently large Reynolds number for strongly stratified flows, experiments for which salt is used to produce the stratification have to be carried out in a large rotating platform of at least 10-meter diameter.We present new experiments done in summer 2017 to study experimentally strongly stratified turbulence and mixing efficiency in the Coriolis platform. The flow is forced by a slow periodic movement of an array of large vertical or horizontal cylinders. The velocity field is measured by 3D-2C scanned horizontal particles image velocimetry (PIV) and 2D vertical PIV. Six density-temperature probes are used to measure vertical and horizontal profiles and signals at fixed positions.We will show how we rely heavily on open-science methods for this study. Our new results on the mixing efficiency will be presented and discussed in terms of mixing parameterization.

  17. GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines

    International Nuclear Information System (INIS)

    Morgan, Kevin; Meyer, Colette; Miller, Nicola; Sims, Andrew H; Cagnan, Ilgin; Faratian, Dana; Harrison, David J; Millar, Robert P; Langdon, Simon P

    2011-01-01

    Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicability of GnRH anti-proliferation to breast cancer was therefore analyzed. GnRH-R expression in 298 primary breast cancer samples was measured by quantitative immunofluorescence. Levels of functional GnRH-R in breast-derived cell lines were assessed using 125 I-ligand binding and stimulation of 3 H-inositol phosphate production. Elevated levels of GnRH-R were stably expressed in cells by transfection. Effects of receptor activation on in vitro cell growth were investigated in comparison with IGF-I and EGF receptor inhibition, and correlated with intracellular signaling using western blotting. GnRH-R immunoscoring was highest in hormone receptor (triple) negative and grade 3 breast tumors. However prior to transfection, functional endogenous GnRH-R were undetectable in four commonly studied breast cancer cell lines (MCF-7, ZR-75-1, T47D and MDA-MB-231). After transfection with GnRH-R, high levels of cell surface GnRH-R were detected in SVCT and MDA-MB-231 clones while low-moderate levels of GnRH-R occurred in MCF-7 clones and ZR-75-1 clones. MCF-7 sub-clones with high levels of GnRH-R were isolated following hygromycin phosphotransferase transfection. High level cell surface GnRH-R enabled induction of high levels of 3 H-inositol phosphate and modest growth-inhibition in SVCT cells. In contrast, growth of MCF-7, ZR-75-1 or MDA-MB-231 clones was unaffected by GnRH-R activation. Cell growth was inhibited by IGF-I or EGF receptor inhibitors. IGF-I receptor inhibitor lowered levels of p-ERK1/2 in MCF-7 clones. Washout of IGF-I receptor inhibitor resulted in transient hyper-elevation of p-ERK1/2, but co-addition of GnRH-R agonist did not alter the dynamics of ERK1/2 re-phosphorylation. Breast cancers exhibit a range of GnRH-R immunostaining, with higher levels of

  18. Fluid Mechanics

    Science.gov (United States)

    Pnueli, David; Gutfinger, Chaim

    1997-01-01

    This text is intended for the study of fluid mechanics at an intermediate level. The presentation starts with basic concepts, in order to form a sound conceptual structure that can support engineering applications and encourage further learning. The presentation is exact, incorporating both the mathematics involved and the physics needed to understand the various phenomena in fluid mechanics. Where a didactical choice must be made between the two, the physics prevails. Throughout the book the authors have tried to reach a balance between exact presentation, intuitive grasp of new ideas, and creative applications of concepts. This approach is reflected in the examples presented in the text and in the exercises given at the end of each chapter. Subjects treated are hydrostatics, viscous flow, similitude and order of magnitude, creeping flow, potential flow, boundary layer flow, turbulent flow, compressible flow, and non-Newtonian flows. This book is ideal for advanced undergraduate students in mechanical, chemical, aerospace, and civil engineering. Solutions manual available.

  19. Fluid dynamics

    CERN Document Server

    Ruban, Anatoly I

    This is the first book in a four-part series designed to give a comprehensive and coherent description of Fluid Dynamics, starting with chapters on classical theory suitable for an introductory undergraduate lecture course, and then progressing through more advanced material up to the level of modern research in the field. The present Part 1 consists of four chapters. Chapter 1 begins with a discussion of Continuum Hypothesis, which is followed by an introduction to macroscopic functions, the velocity vector, pressure, density, and enthalpy. We then analyse the forces acting inside a fluid, and deduce the Navier-Stokes equations for incompressible and compressible fluids in Cartesian and curvilinear coordinates. In Chapter 2 we study the properties of a number of flows that are presented by the so-called exact solutions of the Navier-Stokes equations, including the Couette flow between two parallel plates, Hagen-Poiseuille flow through a pipe, and Karman flow above an infinite rotating disk. Chapter 3 is d...

  20. Vortices in rotating and stratified flows: aspect ratio and sustainability

    Directory of Open Access Journals (Sweden)

    Le Gal P.

    2013-04-01

    Full Text Available In linear stratifications, vortices have a typical flat shape that appears to be not only a compromise between the rotation and the stratification of the background flow through their Coriolis parameter f and buoyancy frequency hbox{$ar{N}$} N̅ , but also involves the buoyancy frequency Nc within the vortices and their Rossby number Ro. We derive an analytical solution for the self-similar ellipsoidal shape of the vortices and the law for their aspect ratio. From this law, we show that long-lived vortices must necessary be either weakly stratified anticyclones or superstratified cyclones (which is less likely to occur. These predictions are experimentally and numerically verified and agree with published measurements for Jovian vortices and ocean meddies. This approach can be applied to a gaussian stratification to give good insights of the shape of vortices in protoplanetary disks and their sustainability.

  1. The optimism trap: Migrants' educational choices in stratified education systems.

    Science.gov (United States)

    Tjaden, Jasper Dag; Hunkler, Christian

    2017-09-01

    Immigrant children's ambitious educational choices have often been linked to their families' high level of optimism and motivation for upward mobility. However, previous research has mostly neglected alternative explanations such as information asymmetries or anticipated discrimination. Moreover, immigrant children's higher dropout rates at the higher secondary and university level suggest that low performing migrant students could have benefitted more from pursuing less ambitious tracks, especially in countries that offer viable vocational alternatives. We examine ethnic minority's educational choices using a sample of academically low performing, lower secondary school students in Germany's highly stratified education system. We find that their families' optimism diverts migrant students from viable vocational alternatives. Information asymmetries and anticipated discrimination do not explain their high educational ambitions. While our findings further support the immigrant optimism hypothesis, we discuss how its effect may have different implications depending on the education system. Copyright © 2017. Published by Elsevier Inc.

  2. The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE)

    DEFF Research Database (Denmark)

    Rubin, Katrine Hass; Holmberg, Teresa; Rothmann, Mette Juel

    2015-01-01

    The risk-stratified osteoporosis strategy evaluation study (ROSE) is a randomized prospective population-based study investigating the effectiveness of a two-step screening program for osteoporosis in women. This paper reports the study design and baseline characteristics of the study population....... 35,000 women aged 65-80 years were selected at random from the population in the Region of Southern Denmark and-before inclusion-randomized to either a screening group or a control group. As first step, a self-administered questionnaire regarding risk factors for osteoporosis based on FRAX......(®) was issued to both groups. As second step, subjects in the screening group with a 10-year probability of major osteoporotic fractures ≥15 % were offered a DXA scan. Patients diagnosed with osteoporosis from the DXA scan were advised to see their GP and discuss pharmaceutical treatment according to Danish...

  3. Internal combustion engine using premixed combustion of stratified charges

    Science.gov (United States)

    Marriott, Craig D [Rochester Hills, MI; Reitz, Rolf D [Madison, WI

    2003-12-30

    During a combustion cycle, a first stoichiometrically lean fuel charge is injected well prior to top dead center, preferably during the intake stroke. This first fuel charge is substantially mixed with the combustion chamber air during subsequent motion of the piston towards top dead center. A subsequent fuel charge is then injected prior to top dead center to create a stratified, locally richer mixture (but still leaner than stoichiometric) within the combustion chamber. The locally rich region within the combustion chamber has sufficient fuel density to autoignite, and its self-ignition serves to activate ignition for the lean mixture existing within the remainder of the combustion chamber. Because the mixture within the combustion chamber is overall premixed and relatively lean, NO.sub.x and soot production are significantly diminished.

  4. Experiments in stratified gas-liquid pipe flow

    NARCIS (Netherlands)

    Birvalski, M.

    2015-01-01

    The growing demand for energy in the future will necessitate the production of natural gas from fields which are located farther offshore, in deep water and in very cold environments. This will confront us with difficulties in ensuring continuous production of the fluids (natural gas, condensate and

  5. Potential Flow Model for Compressible Stratified Rayleigh-Taylor Instability

    Science.gov (United States)

    Rydquist, Grant; Reckinger, Scott; Owkes, Mark; Wieland, Scott

    2017-11-01

    The Rayleigh-Taylor Instability (RTI) is an instability that occurs when a heavy fluid lies on top of a lighter fluid in a gravitational field, or a gravity-like acceleration. It occurs in many fluid flows of a highly compressive nature. In this study potential flow analysis (PFA) is used to model the early stages of RTI growth for compressible fluids. In the localized region near the bubble tip, the effects of vorticity are negligible, so PFA is applicable, as opposed to later stages where the induced velocity due to vortices generated from the growth of the instability dominate the flow. The incompressible PFA is extended for compressibility effects by applying the growth rate and the associated perturbation spatial decay from compressible linear stability theory. The PFA model predicts theoretical values for a bubble terminal velocity for single-mode compressible RTI, dependent upon the Atwood (A) and Mach (M) numbers, which is a parameter that measures both the strength of the stratification and intrinsic compressibility. The theoretical bubble terminal velocities are compared against numerical simulations. The PFA model correctly predicts the M dependence at high A, but the model must be further extended to include additional physics to capture the behavior at low A. Undergraduate Scholars Program - Montana State University.

  6. Particles at fluid-fluid interfaces: A new Navier-Stokes-Cahn-Hilliard surface- phase-field-crystal model

    Science.gov (United States)

    Aland, Sebastian; Lowengrub, John; Voigt, Axel

    2012-10-01

    Colloid particles that are partially wetted by two immiscible fluids can become confined to fluid-fluid interfaces. At sufficiently high volume fractions, the colloids may jam and the interface may crystallize. The fluids together with the interfacial colloids form an emulsion with interesting material properties and offer an important route to new soft materials. A promising approach to simulate these emulsions was presented in Aland [Phys. FluidsPHFLE61070-663110.1063/1.3584815 23, 062103 (2011)], where a Navier-Stokes-Cahn-Hilliard model for the macroscopic two-phase fluid system was combined with a surface phase-field-crystal model for the microscopic colloidal particles along the interface. Unfortunately this model leads to spurious velocities which require very fine spatial and temporal resolutions to accurately and stably simulate. In this paper we develop an improved Navier-Stokes-Cahn-Hilliard-surface phase-field-crystal model based on the principles of mass conservation and thermodynamic consistency. To validate our approach, we derive a sharp interface model and show agreement with the improved diffuse interface model. Using simple flow configurations, we show that the new model has much better properties and does not lead to spurious velocities. Finally, we demonstrate the solid-like behavior of the crystallized interface by simulating the fall of a solid ball through a colloid-laden multiphase fluid.

  7. Particles at fluid-fluid interfaces: A new Navier-Stokes-Cahn-Hilliard surface- phase-field-crystal model.

    Science.gov (United States)

    Aland, Sebastian; Lowengrub, John; Voigt, Axel

    2012-10-01

    Colloid particles that are partially wetted by two immiscible fluids can become confined to fluid-fluid interfaces. At sufficiently high volume fractions, the colloids may jam and the interface may crystallize. The fluids together with the interfacial colloids form an emulsion with interesting material properties and offer an important route to new soft materials. A promising approach to simulate these emulsions was presented in Aland et al. [Phys. Fluids 23, 062103 (2011)], where a Navier-Stokes-Cahn-Hilliard model for the macroscopic two-phase fluid system was combined with a surface phase-field-crystal model for the microscopic colloidal particles along the interface. Unfortunately this model leads to spurious velocities which require very fine spatial and temporal resolutions to accurately and stably simulate. In this paper we develop an improved Navier-Stokes-Cahn-Hilliard-surface phase-field-crystal model based on the principles of mass conservation and thermodynamic consistency. To validate our approach, we derive a sharp interface model and show agreement with the improved diffuse interface model. Using simple flow configurations, we show that the new model has much better properties and does not lead to spurious velocities. Finally, we demonstrate the solid-like behavior of the crystallized interface by simulating the fall of a solid ball through a colloid-laden multiphase fluid.

  8. Mitosis in circulating tumor cells stratifies highly aggressive breast carcinomas.

    Science.gov (United States)

    Adams, Daniel L; Adams, Diane K; Stefansson, Steingrimur; Haudenschild, Christian; Martin, Stuart S; Charpentier, Monica; Chumsri, Saranya; Cristofanilli, Massimo; Tang, Cha-Mei; Alpaugh, R Katherine

    2016-05-04

    Enumeration of circulating tumor cells (CTCs) isolated from the peripheral blood of breast cancer patients holds promise as a clinically relevant, minimally invasive diagnostic test. However, CTC utility has been limited as a prognostic indicator of survival by the inability to stratify patients beyond general enumeration. In comparison, histological biopsy examinations remain the standard method for confirming malignancy and grading malignant cells, allowing for cancer identification and then assessing patient cohorts for prognostic and predictive value. Typically, CTC identification relies on immunofluorescent staining assessed as absent/present, which is somewhat subjective and limited in its ability to characterize these cells. In contrast, the physical features used in histological cytology comprise the gold standard method used to identify and preliminarily characterize the cancer cells. Here, we superimpose the methods, cytologically subtyping CTCs labeled with immunohistochemical fluorescence stains to improve their prognostic value in relation to survival. In this single-blind prospective pilot study, we tracked 36 patients with late-stage breast cancer over 24 months to compare overall survival between simple CTC enumeration and subtyping mitotic CTCs. A power analysis (1-β = 0. 9, α = 0.05) determined that a pilot size of 30 patients was sufficient to stratify this patient cohort; 36 in total were enrolled. Our results confirmed that CTC number is a prognostic indicator of patient survival, with a hazard ratio 5.2, p = 0.005 (95 % CI 1.6-16.5). However, by simply subtyping the same population based on CTCs in cytological mitosis, the hazard ratio increased dramatically to 11.1, p cancer, (2) mitotic CTCs may significantly correlate with shortened overall survival, and (3) larger and more defined patient cohort studies are clearly called for based on this initial pilot study.

  9. Shock propagation and mixing though a stratified gas

    Science.gov (United States)

    Chacon, Fabian; Gamba, Mirko

    2017-11-01

    In this work, we investigate the characteristics of a shock wave propagating through a stratified gas. The objective is to understand the formation and evolution of the system of waves that results from the interaction, as well as the induced mixing. This work is motivated by understanding the shock-induced mixing and system of waves that arise by the interaction of a detonation wave with the fuel/air injection system in a rotating detonation engine. In these devices, one of the key limiting factors in achieving stable detonation and pressure gain is associated with the stratification induced by a non-uniform and incomplete mixing process. To investigate some of the fundamental aspects of the rapid distortion induced by a detonation wave on the non-uniform flow, we conduct a combined analytical and experimental analysis on a simplified and reduced problem. Experimentally, we consider a single row of injectors of regular spacing that generate a non-reacting turbulent non-uniform flow and are subject to an incident transverse normal shock. Different gasses and shock strengths are used to generate a range of density and velocity ratios that are comparable to what could be experienced through a detonation. Using Schlieren and PLIF imaging, the evolution of mixture fraction throughout the flowfield is investigated. The presence of instabilities and the formation of a system of reflected waves is observed and investigated. A variable property, 1-D, multi-isentropic method of characteristics model is constructed to theoretically investigate the shock propagation and interaction with the stratified flow. This work is supported by the DOE/UTSR program under project DE-FE0025315.

  10. Dynamic Transitions and Baroclinic Instability for 3D Continuously Stratified Boussinesq Flows

    Science.gov (United States)

    Şengül, Taylan; Wang, Shouhong

    2018-02-01

    The main objective of this article is to study the nonlinear stability and dynamic transitions of the basic (zonal) shear flows for the three-dimensional continuously stratified rotating Boussinesq model. The model equations are fundamental equations in geophysical fluid dynamics, and dynamics associated with their basic zonal shear flows play a crucial role in understanding many important geophysical fluid dynamical processes, such as the meridional overturning oceanic circulation and the geophysical baroclinic instability. In this paper, first we derive a threshold for the energy stability of the basic shear flow, and obtain a criterion for local nonlinear stability in terms of the critical horizontal wavenumbers and the system parameters such as the Froude number, the Rossby number, the Prandtl number and the strength of the shear flow. Next, we demonstrate that the system always undergoes a dynamic transition from the basic shear flow to either a spatiotemporal oscillatory pattern or circle of steady states, as the shear strength of the basic flow crosses a critical threshold. Also, we show that the dynamic transition can be either continuous or catastrophic, and is dictated by the sign of a transition number, fully characterizing the nonlinear interactions of different modes. Both the critical shear strength and the transition number are functions of the system parameters. A systematic numerical method is carried out to explore transition in different flow parameter regimes. In particular, our numerical investigations show the existence of a hypersurface which separates the parameter space into regions where the basic shear flow is stable and unstable. Numerical investigations also yield that the selection of horizontal wave indices is determined only by the aspect ratio of the box. We find that the system admits only critical eigenmodes with roll patterns aligned with the x-axis. Furthermore, numerically we encountered continuous transitions to multiple

  11. Experimental investigation of droplet separation in a horizontal counter-current air/water stratified flow

    International Nuclear Information System (INIS)

    Gabriel, Stephan Gerhard

    2015-01-01

    A stratified counter-current two-phase gas/liquid flow can occur in various technical systems. In the past investigations have mainly been motivated by the possible occurrence of these flows in accident scenarios of nuclear light water-reactors and in numerous applications in process engineering. However, the precise forecast of flow parameters, is still challenging, for instance due to their strong dependency on the geometric boundary conditions. A new approach which uses CFD methods (Computational Fluid Dynamics) promises a better understanding of the flow phenomena and simultaneously a higher scalability of the findings. RANS methods (Reynolds Averaged Navier Stokes) are preferred in order to compute industrial processes and geometries. A very deep understanding of the flow behavior and equation systems based on real physics are necessary preconditions to develop the equation system for a reliable RANS approach with predictive power. Therefore, local highly resolved, experimental data is needed in order to provide and validate the required turbulence and phase interaction models. The central objective of this work is to provide the data needed for the code development for these unsteady, turbulent and three-dimensional flows. Experiments were carried out at the WENKA facility (Water Entrainment Channel Karlsruhe) at the Karlsruhe Institute of Technology (KIT). The work consists of a detailed description of the test-facility including a new bended channel, the measurement techniques and the experimental results. The characterization of the new channel was done by flow maps. A high-speed imaging study gives an impression of the occurring flow regimes, and different flow phenomena like droplet separation. The velocity distributions as well as various turbulence values were investigated by particle image velocimetry (PIV). In the liquid phase fluorescent tracer-particles were used to suppress optical reflections from the phase surface (fluorescent PIV, FPIV

  12. Fluid mechanics

    International Nuclear Information System (INIS)

    Paraschivoiu, I.; Prud'homme, M.; Robillard, L.; Vasseur, P.

    2003-01-01

    This book constitutes at the same time theoretical and practical base relating to the phenomena associated with fluid mechanics. The concept of continuum is at the base of the approach developed in this work. The general advance proceeds of simple balances of forces as into hydrostatic to more complex situations or inertias, the internal stresses and the constraints of Reynolds are taken into account. This advance is not only theoretical but contains many applications in the form of solved problems, each chapter ending in a series of suggested problems. The major part of the applications relates to the incompressible flows

  13. Fluid Sounds

    DEFF Research Database (Denmark)

    and in architectural design. Aesthetics, psychoacoustics, perception, and cognition are all present in this expanding field embracing such categories as soundscape composition, sound art, sonic art, sound design, sound studies and auditory culture. Of greatest significance to the overall field is the investigation...... of sound, site and the social, and how the spatial, the visual, and the bodily interact in sonic environments, how they are constructed and how they are entangled in other practices. With the Seismograf special issue Fluid Sounds, we bring this knowledge into the dissemination of audio research itself...

  14. Principles of fluid mechanics

    International Nuclear Information System (INIS)

    Kreider, J.F.

    1985-01-01

    This book is an introduction on fluid mechanics incorporating computer applications. Topics covered are as follows: brief history; what is a fluid; two classes of fluids: liquids and gases; the continuum model of a fluid; methods of analyzing fluid flows; important characteristics of fluids; fundamentals and equations of motion; fluid statics; dimensional analysis and the similarity principle; laminar internal flows; ideal flow; external laminar and channel flows; turbulent flow; compressible flow; fluid flow measurements

  15. Resolution of thermal striping issue downstream of a horizontal pipe elbow in stratified pipe flow

    International Nuclear Information System (INIS)

    Kuzay, T.M.; Kasza, K.E.

    1985-01-01

    A thermally stratified pipe flow produced by a thermal transient when passing through a horizontal elbow as a result of secondary flow gives rise to large thermal fluctuations on the inner curvature wall of the downstream piping. These fluctuations were measured in a specially instrumented horizontal pipe and elbow system on a test set-up using water in the Mixing Components Technology Facility (MCTF) at Argonne National Laboratory (ANL). This study is part of a larger program which is studying the influence of thermal buoyancy on general reactor component performance. This paper discusses the influence of pipe flow generated thermal oscillations on the thermal stresses induced in the pipe walls. The instrumentation was concentrated around the exit plane of the 90 0 sweep elbow, since prior tests had indicated that the largest thermal fluctuations would occur within about one hydraulic diameter downstream of the elbow exit. The thermocouples were located along the inner curvature of the piping and measured the near surface fluid temperature. The test matrix involved thermal downramps under turbulent flow conditions

  16. Mixing liquid-liquid stratified flows using transverse jets in cross flows

    Science.gov (United States)

    Wright, Stuart; Matar, Omar K.; Markides, Christos N.

    2017-11-01

    Low pipeline velocities in horizontal liquid-liquid flows lead to gravitationally-induced stratification. This results in flow situations that have no point where average properties can be measured. Inline mixing limits the stratification effect by forming unstable liquid-liquid dispersions. An experimental system is used to measure the mixing performance of various jet-in-cross-flow (JICF) configurations as examples of active inline mixers. The test section consists of a 8.5-m long ETFE pipe with a 50-mm diameter, which is refractive index-matched to both a 10 cSt silicone oil and a 51 wt% glycerol solution. This practice allows advanced laser-based optical techniques, namely PLIF and PIV/PTV, to be applied to these flows in order to measure the phase fractions and velocity fields, respectively. A volume of a fluid (VOF) CFD code is then used to simulate simple jet geometries and to demonstrate the breakup and dispersion capabilities of JICFs in stratified pipeline flows by predicting their mixing efficiency. These simulation results are contrasted with the experimental results to examine the effectiveness of these simulations in predicting the dispersion and breakup. Funding from Cameron/Schlumberger, and the TMF Consortium gratefully acknowledged.

  17. Fast and Accurate Prediction of Stratified Steel Temperature During Holding Period of Ladle

    Science.gov (United States)

    Deodhar, Anirudh; Singh, Umesh; Shukla, Rishabh; Gautham, B. P.; Singh, Amarendra K.

    2017-04-01

    Thermal stratification of liquid steel in a ladle during the holding period and the teeming operation has a direct bearing on the superheat available at the caster and hence on the caster set points such as casting speed and cooling rates. The changes in the caster set points are typically carried out based on temperature measurements at the end of tundish outlet. Thermal prediction models provide advance knowledge of the influence of process and design parameters on the steel temperature at various stages. Therefore, they can be used in making accurate decisions about the caster set points in real time. However, this requires both fast and accurate thermal prediction models. In this work, we develop a surrogate model for the prediction of thermal stratification using data extracted from a set of computational fluid dynamics (CFD) simulations, pre-determined using design of experiments technique. Regression method is used for training the predictor. The model predicts the stratified temperature profile instantaneously, for a given set of process parameters such as initial steel temperature, refractory heat content, slag thickness, and holding time. More than 96 pct of the predicted values are within an error range of ±5 K (±5 °C), when compared against corresponding CFD results. Considering its accuracy and computational efficiency, the model can be extended for thermal control of casting operations. This work also sets a benchmark for developing similar thermal models for downstream processes such as tundish and caster.

  18. Cross-stratified Wood: Enigmatic Woody Debris Deposits in Warm-Polar Fluvial Sediments (Pliocene Beaufort Formation, Nunavut)

    Science.gov (United States)

    Davies, N. S.; Gosse, J. C.; Rybczynski, N.

    2012-04-01

    Woody debris has been an important sediment component and a significant geomorphic agent in pristine fluvial systems since the Devonian. In recent years a large volume of research has focussed on various aspects of the importance of woody debris within the fluvial realm; from the evolutionary significance of fossil wood accumulations in the rock record to studies of the biogeomorphological and ecological importance of woody debris in modern rivers. In this presentation we describe cross-stratified woody debris deposits comprising organic detritus from a boreal-type treeline forest that included species of pine, birch, poplar, alder, spruce, eastern cedar, and larch, in both shrub and tree form. The cross-stratified wood is an enigmatic subset of fine woody debris which, to our knowledge, has never before been described from either the global stratigraphic record or modern fluvial environments. The deposits we describe are located within the Pliocene Beaufort Formation on Meighen Island, Nunavut, Canada, at a latitude of 80°N, and are compared with other cross-stratified woody debris deposits that have been noted elsewhere in the Pliocene of the Canadian Arctic. We make the robust observation that these deposits appear to be geographically and stratigraphically restricted to polar latitudes from a period of warm climatic conditions during the Pliocene (15-20 °C warmer mean annual temperature than the present day). In this regard it is possible to speculate that the transport of large amounts of woody debris as bedload is potentially a unique feature of forested high latitude rivers. Such bedload deposition requires a large amount of woody debris with a greater density than the fluid transporting it. The softwood composition of the debris suggests that this was most likely attained by saturation and subsequent entrainment of extensive accumulations of deadwood, promoted by unusually high rates of tree mortality and low rates of bacterial decomposition arising from

  19. Transition and mixing in layered stratified shear flows.

    Science.gov (United States)

    Lee, Victoria; Caulfield, C. P.

    2001-11-01

    Flows with step-wise density distributions, i.e. well-mixed layers of fluid separated by narrow regions of high density gradient, are common in geophysics. We investigate numerically and theoretically the nonlinear evolution of a parallel shear flow at a moderate Reynolds number which has embedded within it a mixed layer of intermediate fluid. Linear stability theory predicts that the flow may be unstable to stationary vortical disturbances which are a generalization of an inviscid instability first considered by G. I. Taylor. We investigate the behaviour of these "Taylor waves" at finite amplitude through 3D nonlinear numerical simulations. We follow the development of primary and secondary instabilities which contribute to the eventual breakdown of the layered flow. In particular, we are interested in the mixing properties of the flow as it undergoes transition to small-scale disorder.

  20. Fully stratified particle-laden flow in horizontal circular pipe

    Czech Academy of Sciences Publication Activity Database

    Vlasák, Pavel; Kysela, Bohuš; Chára, Zdeněk

    2014-01-01

    Roč. 32, č. 2 (2014), s. 179-185 ISSN 0272-6351. [7th International Conference for Conveying and Handling of Particulate Solids (CHoPS). Friedrichshafen, 10.09.2013-13.09.2012] R&D Projects: GA ČR GAP105/10/1574 Institutional support: RVO:67985874 Keywords : coarse-grained slurry * flow structure * liquid local velocity * particle velocity * PIV Subject RIV: BK - Fluid Dynamics Impact factor: 0.523, year: 2014

  1. Stratified flows with variable density: mathematical modelling and numerical challenges.

    Science.gov (United States)

    Murillo, Javier; Navas-Montilla, Adrian

    2017-04-01

    Stratified flows appear in a wide variety of fundamental problems in hydrological and geophysical sciences. They may involve from hyperconcentrated floods carrying sediment causing collapse, landslides and debris flows, to suspended material in turbidity currents where turbulence is a key process. Also, in stratified flows variable horizontal density is present. Depending on the case, density varies according to the volumetric concentration of different components or species that can represent transported or suspended materials or soluble substances. Multilayer approaches based on the shallow water equations provide suitable models but are not free from difficulties when moving to the numerical resolution of the governing equations. Considering the variety of temporal and spatial scales, transfer of mass and energy among layers may strongly differ from one case to another. As a consequence, in order to provide accurate solutions, very high order methods of proved quality are demanded. Under these complex scenarios it is necessary to observe that the numerical solution provides the expected order of accuracy but also converges to the physically based solution, which is not an easy task. To this purpose, this work will focus in the use of Energy balanced augmented solvers, in particular, the Augmented Roe Flux ADER scheme. References: J. Murillo , P. García-Navarro, Wave Riemann description of friction terms in unsteady shallow flows: Application to water and mud/debris floods. J. Comput. Phys. 231 (2012) 1963-2001. J. Murillo B. Latorre, P. García-Navarro. A Riemann solver for unsteady computation of 2D shallow flows with variable density. J. Comput. Phys.231 (2012) 4775-4807. A. Navas-Montilla, J. Murillo, Energy balanced numerical schemes with very high order. The Augmented Roe Flux ADER scheme. Application to the shallow water equations, J. Comput. Phys. 290 (2015) 188-218. A. Navas-Montilla, J. Murillo, Asymptotically and exactly energy balanced augmented flux

  2. Deep silicon maxima in the stratified oligotrophic Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    Y. Crombet

    2011-02-01

    Full Text Available The silicon biogeochemical cycle has been studied in the Mediterranean Sea during late summer/early autumn 1999 and summer 2008. The distribution of nutrients, particulate carbon and silicon, fucoxanthin (Fuco, and total chlorophyll-a (TChl-a were investigated along an eastward gradient of oligotrophy during two cruises (PROSOPE and BOUM encompassing the entire Mediterranean Sea during the stratified period. At both seasons, surface waters were depleted in nutrients and the nutriclines gradually deepened towards the East, the phosphacline being the deepest in the easternmost Levantine basin. Following the nutriclines, parallel deep maxima of biogenic silica (DSM, fucoxanthin (DFM and TChl-a (DCM were evidenced during both seasons with maximal concentrations of 0.45 μmol L−1 for BSi, 0.26 μg L−1 for Fuco, and 1.70 μg L−1 for TChl-a, all measured during summer. Contrary to the DCM which was a persistent feature in the Mediterranean Sea, the DSM and DFMs were observed in discrete areas of the Alboran Sea, the Algero-Provencal basin, the Ionian sea and the Levantine basin, indicating that diatoms were able to grow at depth and dominate the DCM under specific conditions. Diatom assemblages were dominated by Chaetoceros spp., Leptocylindrus spp., Pseudonitzschia spp. and the association between large centric diatoms (Hemiaulus hauckii and Rhizosolenia styliformis and the cyanobacterium Richelia intracellularis was observed at nearly all sites. The diatom's ability to grow at depth is commonly observed in other oligotrophic regions and could play a major role in ecosystem productivity and carbon export to depth. Contrary to the common view that Si and siliceous phytoplankton are not major components of the Mediterranean biogeochemistry, we suggest here that diatoms, by persisting at depth during the stratified period, could contribute to a

  3. Stratified patterns of divorce: Earnings, education, and gender

    Directory of Open Access Journals (Sweden)

    Amit Kaplan

    2015-05-01

    Full Text Available Background: Despite evidence that divorce has become more prevalent among weaker socioeconomic groups, knowledge about the stratification aspects of divorce in Israel is lacking. Moreover, although scholarly debate recognizes the importance of stratificational positions with respect to divorce, less attention has been given to the interactions between them. Objective: Our aim is to examine the relationship between social inequality and divorce, focusing on how household income, education, employment stability, relative earnings, and the intersection between them affect the risk of divorce in Israel. Methods: The data is derived from combined census files for 1995-2008, annual administrative employment records from the National Insurance Institute and the Tax Authority, and data from the Civil Registry of Divorce. We used a series of discrete-time event-history analysis models for marital dissolution. Results: Couples in lower socioeconomic positions had a higher risk of divorce in Israel. Higher education in general, and homogamy in terms of higher education (both spouses have degrees in particular, decreased the risk of divorce. The wife's relative earnings had a differential effect on the likelihood of divorce, depending on household income: a wife who outearned her husband increased the log odds of divorce more in the upper tertiles than in the lower tertile. Conclusions: Our study shows that divorce indeed has a stratified pattern and that weaker socioeconomic groups experience the highest levels of divorce. Gender inequality within couples intersects with the household's economic and educational resources.

  4. Computational method for transmission eigenvalues for a spherically stratified medium.

    Science.gov (United States)

    Cheng, Xiaoliang; Yang, Jing

    2015-07-01

    We consider a computational method for the interior transmission eigenvalue problem that arises in acoustic and electromagnetic scattering. The transmission eigenvalues contain useful information about some physical properties, such as the index of refraction. Instead of the existence and estimation of the spectral property of the transmission eigenvalues, we focus on the numerical calculation, especially for spherically stratified media in R3. Due to the nonlinearity and the special structure of the interior transmission eigenvalue problem, there are not many numerical methods to date. First, we reduce the problem into a second-order ordinary differential equation. Then, we apply the Hermite finite element to the weak formulation of the equation. With proper rewriting of the matrix-vector form, we change the original nonlinear eigenvalue problem into a quadratic eigenvalue problem, which can be written as a linear system and solved by the eigs function in MATLAB. This numerical method is fast, effective, and can calculate as many transmission eigenvalues as needed at a time.

  5. Economic evaluation in stratified medicine: methodological issues and challenges

    Directory of Open Access Journals (Sweden)

    Hans-Joerg eFugel

    2016-05-01

    Full Text Available Background: Stratified Medicine (SM is becoming a practical reality with the targeting of medicines by using a biomarker or genetic-based diagnostic to identify the eligible patient sub-population. Like any healthcare intervention, SM interventions have costs and consequences that must be considered by reimbursement authorities with limited resources. Methodological standards and guidelines exist for economic evaluations in clinical pharmacology and are an important component for health technology assessments (HTAs in many countries. However, these guidelines have initially been developed for traditional pharmaceuticals and not for complex interventions with multiple components. This raises the issue as to whether these guidelines are adequate to SM interventions or whether new specific guidance and methodology is needed to avoid inconsistencies and contradictory findings when assessing economic value in SM.Objective: This article describes specific methodological challenges when conducting health economic (HE evaluations for SM interventions and outlines potential modifications necessary to existing evaluation guidelines /principles that would promote consistent economic evaluations for SM.Results/Conclusions: Specific methodological aspects for SM comprise considerations on the choice of comparator, measuring effectiveness and outcomes, appropriate modelling structure and the scope of sensitivity analyses. Although current HE methodology can be applied for SM, greater complexity requires further methodology development and modifications in the guidelines.

  6. Stratifying the Risk of Venous Thromboembolism in Otolaryngology

    Science.gov (United States)

    Shuman, Andrew G.; Hu, Hsou Mei; Pannucci, Christopher J.; Jackson, Christopher R.; Bradford, Carol R.; Bahl, Vinita

    2015-01-01

    Objective The consequences of perioperative venous thromboembolism (VTE) are devastating; identifying patients at risk is an essential step in reducing morbidity and mortality. The utility of perioperative VTE risk assessment in otolaryngology is unknown. This study was designed to risk-stratify a diverse population of otolaryngology patients for VTE events. Study Design Retrospective cohort study. Setting Single-institution academic tertiary care medical center. Subjects and Methods Adult patients presenting for otolaryngologic surgery requiring hospital admission from 2003 to 2010 who did not receive VTE chemoprophylaxis were included. The Caprini risk assessment was retrospectively scored via a validated method of electronic chart abstraction. Primary study variables were Caprini risk scores and the incidence of perioperative venous thromboembolic outcomes. Results A total of 2016 patients were identified. The overall 30-day rate of VTE was 1.3%. The incidence of VTE in patients with a Caprini risk score of 6 or less was 0.5%. For patients with scores of 7 or 8, the incidence was 2.4%. Patients with a Caprini risk score greater than 8 had an 18.3% incidence of VTE and were significantly more likely to develop a VTE when compared to patients with a Caprini risk score less than 8 (P otolaryngology patients for 30-day VTE events and allows otolaryngologists to identify patient subgroups who have a higher risk of VTE in the absence of chemoprophylaxis. PMID:22261490

  7. Clinical research in small genomically stratified patient populations.

    Science.gov (United States)

    Martin-Liberal, J; Rodon, J

    2017-07-01

    The paradigm of early drug development in cancer is shifting from 'histology-oriented' to 'molecularly oriented' clinical trials. This change can be attributed to the vast amount of tumour biology knowledge generated by large international research initiatives such as The Cancer Genome Atlas (TCGA) and the use of next generation sequencing (NGS) techniques developed in recent years. However, targeting infrequent molecular alterations entails a series of special challenges. The optimal molecular profiling method, the lack of standardised biological thresholds, inter- and intra-tumor heterogeneity, availability of enough tumour material, correct clinical trials design, attrition rate, logistics or costs are only some of the issues that need to be taken into consideration in clinical research in small genomically stratified patient populations. This article examines the most relevant challenges inherent to clinical research in these populations. Moreover, perspectives from the Academia point of view are reviewed as well as initiatives to be taken in forthcoming years. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Distribution-Preserving Stratified Sampling for Learning Problems.

    Science.gov (United States)

    Cervellera, Cristiano; Maccio, Danilo

    2017-06-09

    The need for extracting a small sample from a large amount of real data, possibly streaming, arises routinely in learning problems, e.g., for storage, to cope with computational limitations, obtain good training/test/validation sets, and select minibatches for stochastic gradient neural network training. Unless we have reasons to select the samples in an active way dictated by the specific task and/or model at hand, it is important that the distribution of the selected points is as similar as possible to the original data. This is obvious for unsupervised learning problems, where the goal is to gain insights on the distribution of the data, but it is also relevant for supervised problems, where the theory explains how the training set distribution influences the generalization error. In this paper, we analyze the technique of stratified sampling from the point of view of distances between probabilities. This allows us to introduce an algorithm, based on recursive binary partition of the input space, aimed at obtaining samples that are distributed as much as possible as the original data. A theoretical analysis is proposed, proving the (greedy) optimality of the procedure together with explicit error bounds. An adaptive version of the algorithm is also introduced to cope with streaming data. Simulation tests on various data sets and different learning tasks are also provided.

  9. Self-Knowledge and Risk in Stratified Medicine.

    Science.gov (United States)

    Hordern, Joshua

    2017-04-01

    This article considers why and how self-knowledge is important to communication about risk and behaviour change by arguing for four claims. First, it is doubtful that genetic knowledge should properly be called 'self-knowledge' when its ordinary effects on self-motivation and behaviour change seem so slight. Second, temptations towards a reductionist, fatalist, construal of persons' futures through a 'molecular optic' should be resisted. Third, any plausible effort to change people's behaviour must engage with cultural self-knowledge, values and beliefs, catalysed by the communication of genetic risk. For example, while a Judaeo-Christian notion of self-knowledge is distinctively theological, people's self-knowledge is plural in its insight and sources. Fourth, self-knowledge is found in compassionate, if tense, communion which yields freedom from determinism even amidst suffering. Stratified medicine thus offers a newly precise kind of humanising health care through societal solidarity with the riskiest. However, stratification may also mean that molecularly unstratified, 'B' patients' experience involves accentuated suffering and disappointment, a concern requiring further research.

  10. Operations and Maintenance Cost for Stratified Buildings: A Critical Review

    Directory of Open Access Journals (Sweden)

    Che-Ghani Nor Zaimah

    2016-01-01

    Full Text Available Building maintenance is essential in preserving buildings’ appearance and performance. It needs to upkeep the building performance to prolong its value and building life cycle. Malaysia is still lacking in managing cost for building operation and maintenance. It has been found that the cost for housing maintenance is high due to poor maintenance practices. In order to get better understanding on how to manage the cost, this study reviews the contributing factors that affecting operation and maintenance cost of stratified buildings in Malaysia. The research first identified the factors through extensive literature review and scrutinize on factors that affecting and can minimize operation and maintenance cost. This literature review offers insight into building maintenance scenario in Malaysia focusing on the issues and challenges. The study also finds that operation and maintenance cost for housing in Malaysia is still in poor state. Interestingly, this paper revealed that operation and maintenance cost is also influenced by three significant factors like expectation of tenants, building characteristics and building defects. Measures to reduce the housing operation and maintenance cost are also highlighted so that this study can be a stepping stone towards proposing efficient and effective facilities management strategies for affordable housing in future.

  11. Gyroelastic fluids

    Energy Technology Data Exchange (ETDEWEB)

    Kerbel, G.D.

    1981-01-20

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch.

  12. Gyroelastic fluids

    International Nuclear Information System (INIS)

    Kerbel, G.D.

    1981-01-01

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch

  13. Thermal stratification built up in hot water tank with different inlet stratifiers

    DEFF Research Database (Denmark)

    Dragsted, Janne; Furbo, Simon; Dannemand, Mark

    2017-01-01

    in order to elucidate how well thermal stratification is established in the tank with differently designed inlet stratifiers under different controlled laboratory conditions. The investigated inlet stratifiers are from Solvis GmbH & Co KG and EyeCular Technologies ApS. The inlet stratifier from Solvis Gmb......Thermal stratification in a water storage tank can strongly increase the thermal performance of solar heating systems. Thermal stratification can be built up in a storage tank during charge, if the heated water enters through an inlet stratifier. Experiments with a test tank have been carried out......H is a rigid plastic pipe with holes for each 30 cm. The holes are designed with flaps preventing counter flow into the pipe. The inlet stratifier from EyeCular Technologies ApS is made of a flexible polymer with openings all along the side and in the full length of the stratifier. The flexibility...

  14. Estimating the Population Mean by Using Stratified Double Extreme Ranked Set Sample

    OpenAIRE

    Mahmoud I. Syam; Kamarulzaman Ibrahim; Amer I. Al-Omari

    2015-01-01

    Stratified double extreme ranked set sampling (SDERSS) method is introduced and considered for estimating the population mean. The SDERSS is compared with the simple random sampling (SRS), stratified ranked set sampling (SRSS) and stratified simple set sampling (SSRS). It is shown that the SDERSS estimator is an unbiased of the population mean and more efficient than the estimators using SRS, SRSS and SSRS when the underlying distribution of the variable of interest is sy...

  15. Computation of potentials from current electrodes in cylindrically stratified media: A stable, rescaled semi-analytical formulation

    Science.gov (United States)

    Moon, Haksu; Teixeira, Fernando L.; Donderici, Burkay

    2015-01-01

    We present an efficient and robust semi-analytical formulation to compute the electric potential due to arbitrary-located point electrodes in three-dimensional cylindrically stratified media, where the radial thickness and the medium resistivity of each cylindrical layer can vary by many orders of magnitude. A basic roadblock for robust potential computations in such scenarios is the poor scaling of modified-Bessel functions used for computation of the semi-analytical solution, for extreme arguments and/or orders. To accommodate this, we construct a set of rescaled versions of modified-Bessel functions, which avoids underflows and overflows in finite precision arithmetic, and minimizes round-off errors. In addition, several extrapolation methods are applied and compared to expedite the numerical evaluation of the (otherwise slowly convergent) associated Sommerfeld-type integrals. The proposed algorithm is verified in a number of scenarios relevant to geophysical exploration, but the general formulation presented is also applicable to other problems governed by Poisson equation such as Newtonian gravity, heat flow, and potential flow in fluid mechanics, involving cylindrically stratified environments.

  16. Downstream and soaring interfaces and vortices in 2-D stratified wakes and their impact on transport of contaminants

    Directory of Open Access Journals (Sweden)

    Y. D. Chashechkin

    2006-01-01

    Full Text Available The flow of continuously stratified fluids past obstacles was studied analytically, numerically, and experimentally. The obstacles discussed here include a flat strip, aligned with the flow, inclined or transverse to the flow and a horizontal cylinder. In the flow pattern, transient and attached (lee internal waves, downstream wakes with submerged interfaces and vortices, soaring singular interfaces, soaring vortices and vortex systems are distinguished. New components of laminar flow past a horizontally towed strip are presented. Fine transverse streaky structures on the strip in the downstream wake were visualized. Soaring isolated interfaces, which are internal boundary layers forming inside the downstream attached wave field past bluff bodies were observed. With increasing of the body velocity a vortex pair was formed directly at the leading edge of this interface.

  17. Thermophysical Properties of Fluids and Fluid Mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Sengers, Jan V.; Anisimov, Mikhail A.

    2004-05-03

    The major goal of the project was to study the effect of critical fluctuations on the thermophysical properties and phase behavior of fluids and fluid mixtures. Long-range fluctuations appear because of the presence of critical phase transitions. A global theory of critical fluctuations was developed and applied to represent thermodynamic properties and transport properties of molecular fluids and fluid mixtures. In the second phase of the project, the theory was extended to deal with critical fluctuations in complex fluids such as polymer solutions and electrolyte solutions. The theoretical predictions have been confirmed by computer simulations and by light-scattering experiments. Fluctuations in fluids in nonequilibrium states have also been investigated.

  18. Germination of embryos from stratified and non-stratified seeds and growth of apple seedlings (Malus domestica Borkh cv. "Antonówka"

    Directory of Open Access Journals (Sweden)

    Jerzy Czerski

    2014-01-01

    Full Text Available The germination of whole seeds, the seeds without coat and isolated embryos of apple cv. "Antonówka Zwykła" after 90 days of cold-stratification was compared with the germination of embryos isolated from non-stratified seeds. They were germinated under 16hrs during a day at temperature 25°C and 20°C during the night. It has been found that after 2 weeks whole stratified seeds germinated in 5 per cent, seeds without coat in 25 per cent and isolated embryos in 98 per cent. Isolated embryos from nun-stratified seeds, after 2 weeks, germinated in the range from 75 to 88 per cent. The results indicate the similar germination ability of embryos isolated from nun-stratified seeds. The seedling populations obtained from embryo's stratified and non-stratified seeds were fully comparable and they evaluated: 1 a wide range of individual differences within population, 2 a similar number of seedlings in each class of shoot length, 3 a similar morphological habitus in each class of shoot length, 4 a similar fresh leaf weight and whole plant increment.

  19. Automatic fluid dispenser

    Science.gov (United States)

    Sakellaris, P. C. (Inventor)

    1977-01-01

    Fluid automatically flows to individual dispensing units at predetermined times from a fluid supply and is available only for a predetermined interval of time after which an automatic control causes the fluid to drain from the individual dispensing units. Fluid deprivation continues until the beginning of a new cycle when the fluid is once again automatically made available at the individual dispensing units.

  20. Efficient propagation of progressive multifocal leukoencephalopathy-type JC virus in COS-7-derived cell lines stably expressing Tat protein of human immunodeficiency virus type 1.

    Science.gov (United States)

    Nukuzuma, Souichi; Nakamichi, Kazuo; Kameoka, Masanori; Sugiura, Shigeki; Nukuzuma, Chiyoko; Miyoshi, Isao; Takegami, Tsutomu

    2010-12-01

    The high incidence of progressive multifocal leukoencephalopathy (PML) in AIDS patients compared with many other immunosuppressive diseases suggests that HIV-1 infection is strictly related to the activation of JC virus (JCV) propagation. In this report, propagation of PML-type JCV in COS-7-derived cell lines stably expressing HIV-1 Tat (COS-tat cells) has been examined. In COS-tat cells, production of viral particles and replication of genomic DNA were markedly increased compared to COS-7 cells, as judged by HA and real-time PCR analyses. These results demonstrate that COS-tat cells provide a useful model system for studying HIV-1 Tat-mediated propagation of PML-type JCV. © 2010 The Societies and Blackwell Publishing Asia Pty Ltd.

  1. Water-resistant, monodispersed and stably luminescent CsPbBr3/CsPb2Br5 core-shell-like structure lead halide perovskite nanocrystals

    Science.gov (United States)

    Qiao, Bo; Song, Pengjie; Cao, Jingyue; Zhao, Suling; Shen, Zhaohui; Gao, Di; Liang, Zhiqin; Xu, Zheng; Song, Dandan; Xu, Xurong

    2017-11-01

    Lead halide perovskite materials are thriving in optoelectronic applications due to their excellent properties, while their instability due to the fact that they are easily hydrolyzed is still a bottleneck for their potential application. In this work, water-resistant, monodispersed and stably luminescent cesium lead bromine perovskite nanocrystals coated with CsPb2Br5 were obtained using a modified non-stoichiometric solution-phase method. CsPb2Br5 2D layers were coated on the surface of CsPbBr3 nanocrystals and formed a core-shell-like structure in the synthetic processes. The stability of the luminescence of the CsPbBr3 nanocrystals in water and ethanol atmosphere was greatly enhanced by the photoluminescence-inactive CsPb2Br5 coating with a wide bandgap. The water-stable enhanced nanocrystals are suitable for long-term stable optoelectronic applications in the atmosphere.

  2. Fluid Mechanics and Fluid Power (FMFP)

    Indian Academy of Sciences (India)

    Amitabh Bhattacharya

    decades, mainly due to the rapid improvement in computational efficiency, cameras, optics and instrumentation, both computational and experimental techniques have improved significantly, allowing researchers in Fluid Mechanics to build better mechanistic and analytical models for processes involving dynamics of fluids.

  3. Fluid Mechanics and Fluid Power (FMFP)

    Indian Academy of Sciences (India)

    Amitabh Bhattacharya

    of renewable energy (e.g., via wind, hydrokinetic generators), creating low-cost healthcare (e.g., via point-of-care medical testing) and improvement of energy efficiency of fluid power systems, depends on improving our understanding of Fluid. Mechanics. Fluids are ubiquitous in both nature and technological applications, ...

  4. Stratified magnetically driven accretion-disk winds and their relations to jets

    International Nuclear Information System (INIS)

    Fukumura, Keigo; Tombesi, Francesco; Kazanas, Demosthenes; Shrader, Chris; Behar, Ehud; Contopoulos, Ioannis

    2014-01-01

    We explore the poloidal structure of two-dimensional magnetohydrodynamic (MHD) winds in relation to their potential association with the X-ray warm absorbers (WAs) and the highly ionized ultra-fast outflows (UFOs) in active galactic nuclei (AGNs), in a single unifying approach. We present the density n(r, θ), ionization parameter ξ(r, θ), and velocity structure v(r, θ) of such ionized winds for typical values of their fluid-to-magnetic flux ratio, F, and specific angular momentum, H, for which wind solutions become super-Alfvénic. We explore the geometrical shape of winds for different values of these parameters and delineate the values that produce the widest and narrowest opening angles of these winds, quantities necessary in the determination of the statistics of AGN obscuration. We find that winds with smaller H show a poloidal geometry of narrower opening angles with their Alfvén surface at lower inclination angles and therefore they produce the highest line of sight (LoS) velocities for observers at higher latitudes with the respect to the disk plane. We further note a physical and spatial correlation between the X-ray WAs and UFOs that form along the same LoS to the observer but at different radii, r, and distinct values of n, ξ, and v consistent with the latest spectroscopic data of radio-quiet Seyfert galaxies. We also show that, at least in the case of 3C 111, the winds' pressure is sufficient to contain the relativistic plasma responsible for its radio emission. Stratified MHD disk winds could therefore serve as a unique means to understand and unify the diverse AGN outflows.

  5. Instabilities of continuously stratified zonal equatorial jets in a periodic channel model

    Directory of Open Access Journals (Sweden)

    S. Masina

    Full Text Available Several numerical experiments are performed in a nonlinear, multi-level periodic channel model centered on the equator with different zonally uniform background flows which resemble the South Equatorial Current (SEC. Analysis of the simulations focuses on identifying stability criteria for a continuously stratified fluid near the equator. A 90 m deep frontal layer is required to destabilize a zonally uniform, 10° wide, westward surface jet that is symmetric about the equator and has a maximum velocity of 100 cm/s. In this case, the phase velocity of the excited unstable waves is very similar to the phase speed of the Tropical Instability Waves (TIWs observed in the eastern Pacific Ocean. The vertical scale of the baroclinic waves corresponds to the frontal layer depth and their phase speed increases as the vertical shear of the jet is doubled. When the westward surface parabolic jet is made asymmetric about the equator, in order to simulate more realistically the structure of the SEC in the eastern Pacific, two kinds of instability are generated. The oscillations that grow north of the equator have a baroclinic nature, while those generated on and very close to the equator have a barotropic nature. 

    This study shows that the potential for baroclinic instability in the equatorial region can be as large as at mid-latitudes, if the tendency of isotherms to have a smaller slope for a given zonal velocity, when the Coriolis parameter vanishes, is compensated for by the wind effect.

    Key words. Oceanography: general (equatorial oceanography; numerical modeling – Oceanography: physics (fronts and jets

  6. Instabilities of continuously stratified zonal equatorial jets in a periodic channel model

    Directory of Open Access Journals (Sweden)

    S. Masina

    2002-05-01

    Full Text Available Several numerical experiments are performed in a nonlinear, multi-level periodic channel model centered on the equator with different zonally uniform background flows which resemble the South Equatorial Current (SEC. Analysis of the simulations focuses on identifying stability criteria for a continuously stratified fluid near the equator. A 90 m deep frontal layer is required to destabilize a zonally uniform, 10° wide, westward surface jet that is symmetric about the equator and has a maximum velocity of 100 cm/s. In this case, the phase velocity of the excited unstable waves is very similar to the phase speed of the Tropical Instability Waves (TIWs observed in the eastern Pacific Ocean. The vertical scale of the baroclinic waves corresponds to the frontal layer depth and their phase speed increases as the vertical shear of the jet is doubled. When the westward surface parabolic jet is made asymmetric about the equator, in order to simulate more realistically the structure of the SEC in the eastern Pacific, two kinds of instability are generated. The oscillations that grow north of the equator have a baroclinic nature, while those generated on and very close to the equator have a barotropic nature.  This study shows that the potential for baroclinic instability in the equatorial region can be as large as at mid-latitudes, if the tendency of isotherms to have a smaller slope for a given zonal velocity, when the Coriolis parameter vanishes, is compensated for by the wind effect.Key words. Oceanography: general (equatorial oceanography; numerical modeling – Oceanography: physics (fronts and jets

  7. Stratified magnetically driven accretion-disk winds and their relations to jets

    Energy Technology Data Exchange (ETDEWEB)

    Fukumura, Keigo [University of Maryland, Baltimore County (UMBC/CRESST), Baltimore, MD 21250 (United States); Tombesi, Francesco; Kazanas, Demosthenes; Shrader, Chris [Astrophysics Science Division, NASA/Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Behar, Ehud [Department of Physics, Technion, Haifa 32000 (Israel); Contopoulos, Ioannis, E-mail: fukumukx@jmu.edu [Research Center for Astronomy, Academy of Athens, Athens 11527 (Greece)

    2014-01-10

    We explore the poloidal structure of two-dimensional magnetohydrodynamic (MHD) winds in relation to their potential association with the X-ray warm absorbers (WAs) and the highly ionized ultra-fast outflows (UFOs) in active galactic nuclei (AGNs), in a single unifying approach. We present the density n(r, θ), ionization parameter ξ(r, θ), and velocity structure v(r, θ) of such ionized winds for typical values of their fluid-to-magnetic flux ratio, F, and specific angular momentum, H, for which wind solutions become super-Alfvénic. We explore the geometrical shape of winds for different values of these parameters and delineate the values that produce the widest and narrowest opening angles of these winds, quantities necessary in the determination of the statistics of AGN obscuration. We find that winds with smaller H show a poloidal geometry of narrower opening angles with their Alfvén surface at lower inclination angles and therefore they produce the highest line of sight (LoS) velocities for observers at higher latitudes with the respect to the disk plane. We further note a physical and spatial correlation between the X-ray WAs and UFOs that form along the same LoS to the observer but at different radii, r, and distinct values of n, ξ, and v consistent with the latest spectroscopic data of radio-quiet Seyfert galaxies. We also show that, at least in the case of 3C 111, the winds' pressure is sufficient to contain the relativistic plasma responsible for its radio emission. Stratified MHD disk winds could therefore serve as a unique means to understand and unify the diverse AGN outflows.

  8. Stratified Magnetically Driven Accretion-disk Winds and Their Relations to Jets

    Science.gov (United States)

    Fukumura, Keigo; Tombesi, Francesco; Kazanas, Demosthenes; Shrader, Chris; Behar, Ehud; Contopoulos, Ioannis

    2014-01-01

    We explore the poloidal structure of two-dimensional magnetohydrodynamic (MHD) winds in relation to their potential association with the X-ray warm absorbers (WAs) and the highly ionized ultra-fast outflows (UFOs) in active galactic nuclei (AGNs), in a single unifying approach. We present the density n(r, θ), ionization parameter ξ(r, θ), and velocity structure v(r, θ) of such ionized winds for typical values of their fluid-to-magnetic flux ratio, F, and specific angular momentum, H, for which wind solutions become super-Alfvénic. We explore the geometrical shape of winds for different values of these parameters and delineate the values that produce the widest and narrowest opening angles of these winds, quantities necessary in the determination of the statistics of AGN obscuration. We find that winds with smaller H show a poloidal geometry of narrower opening angles with their Alfvén surface at lower inclination angles and therefore they produce the highest line of sight (LoS) velocities for observers at higher latitudes with the respect to the disk plane. We further note a physical and spatial correlation between the X-ray WAs and UFOs that form along the same LoS to the observer but at different radii, r, and distinct values of n, ξ, and v consistent with the latest spectroscopic data of radio-quiet Seyfert galaxies. We also show that, at least in the case of 3C 111, the winds' pressure is sufficient to contain the relativistic plasma responsible for its radio emission. Stratified MHD disk winds could therefore serve as a unique means to understand and unify the diverse AGN outflows.

  9. Large eddy simulation of very-large-scale motions in the neutrally stratified atmospheric boundary layer

    Science.gov (United States)

    Fang, Jiannong; Porté-Agel, Fernando

    2014-05-01

    Large eddy simulation was used to investigate the very-large-scale motions (VLSM) in the neutrally stratified atmospheric boundary layer at a very high friction Reynolds number. The vertical height of the computational domain is Lz = 1000 m, which corresponds to the thickness of the boundary layer. The horizontal dimensions of the simulation domain are chosen to be Lx = 32Lz and Ly = 4Lz respectively, in order to contain a sufficient number of large-scale structures. The spatially coherent structures associated with VLSM are characterized through flow visualization and statistical analysis. The instantaneous velocity fields in streamwise/spanwise planes give evidence of streamwise-elongated zones of low speed fluid with negative streamwise velocity fluctuation, which is flanked on either side by similarly elongated high speed ones. The pre-multiplied power spectra and two-point correlations indicate that the scales of these streak-like structures are very large, up to 20Lz in the streamwise direction and Lz in the spanwise direction. These features are similar to what have been found in the logarithmic region of laboratory-scale boundary layers by direct numerical simulations and experiments conducted at low to moderate Reynolds numbers. The three dimensional correlation map and conditional average of the three components of velocity further indicate that the low-speed and high-speed regions possess the same elongated ellipsoid-like structure, which is inclined upward along the streamwise direction, and they are accompanied by counter-rotating roll modes in the cross section perpendicular to the streamwise direction. These findings are in agreement with recent observations made from field campaigns in the atmospheric boundary layer.

  10. Properties of the endogenous post-stratified estimator using a random forests model

    Science.gov (United States)

    John Tipton; Jean Opsomer; Gretchen G. Moisen

    2012-01-01

    Post-stratification is used in survey statistics as a method to improve variance estimates. In traditional post-stratification methods, the variable on which the data is being stratified must be known at the population level. In many cases this is not possible, but it is possible to use a model to predict values using covariates, and then stratify on these predicted...

  11. Implementing content constraints in alpha-stratified adaptive testing using a shadow test approach

    NARCIS (Netherlands)

    van der Linden, Willem J.; Chang, Hua-Hua

    2001-01-01

    The methods of alpha-stratified adaptive testing and constrained adaptive testing with shadow tests are combined in this study. The advantages are twofold. First, application of the shadow test allows the researcher to implement any type of constraint on item selection in alpha-stratified adaptive

  12. Indications for tonsillectomy stratified by the level of evidence

    Science.gov (United States)

    Windfuhr, Jochen P.

    2016-01-01

    Background: One of the most significant clinical trials, demonstrating the efficacy of tonsillectomy (TE) for recurrent throat infection in severely affected children, was published in 1984. This systematic review was undertaken to compile various indications for TE as suggested in the literature after 1984 and to stratify the papers according to the current concept of evidence-based medicine. Material and methods: A systematic Medline research was performed using the key word of “tonsillectomy“ in combination with different filters such as “systematic reviews“, “meta-analysis“, “English“, “German“, and “from 1984/01/01 to 2015/05/31“. Further research was performed in the Cochrane Database of Systematic Reviews, National Guideline Clearinghouse, Guidelines International Network and BMJ Clinical Evidence using the same key word. Finally, data from the “Trip Database” were researched for “tonsillectomy” and “indication“ and “from: 1984 to: 2015“ in combination with either “systematic review“ or “meta-analysis“ or “metaanalysis”. Results: A total of 237 papers were retrieved but only 57 matched our inclusion criteria covering the following topics: peritonsillar abscess (3), guidelines (5), otitis media with effusion (5), psoriasis (3), PFAPA syndrome (6), evidence-based indications (5), renal diseases (7), sleep-related breathing disorders (11), and tonsillitis/pharyngitis (12), respectively. Conclusions: 1) The literature suggests, that TE is not indicated to treat otitis media with effusion. 2) It has been shown, that the PFAPA syndrome is self-limiting and responds well to steroid administration, at least in a considerable amount of children. The indication for TE therefore appears to be imbalanced but further research is required to clarify the value of surgery. 3) Abscesstonsillectomy as a routine is not justified and indicated only for cases not responding to other measures of treatment, evident complications

  13. An Instability in Stratified Taylor-Couette Flow

    Science.gov (United States)

    Swinney, Harry

    2015-11-01

    In the late 1950s Russell Donnelly began conducting experiments at the University of Chicago on flow between concentric rotating cylinders, and his experiments together with complementary theory by his collaborator S. Chandrasekhar did much to rekindle interest in the flow instability discovered and studied by G.I. Taylor (1923). The present study concerns an instability in a concentric cylinder system containing a fluid with an axial density gradient. In 2005 Dubrulle et al. suggested that a `stratorotational instability' (SRI) in this system could provide insight into instability and angular momentum transport in astrophysical accretion disks. In 2007 the stratorotational instability was observed in experiments by Le Bars and Le Gal. We have conducted an experiment on the SRI in a concentric cylinder system (radius ratio η = 0 . 876) with buoyancy frequency N / 2 π = 0.25, 0.50, or 0.75 Hz. For N = 0.75 Hz we observe the SRI onset to occur for Ωouter /Ωinner > η , contrary to the prediction of Shalybkov and Rüdiger. Research conducted with Bruce Rodenborn and Ruy Ibanez.

  14. Thermally stratified flow of second grade fluid with non-Fourier heat flux and temperature dependent thermal conductivity

    Science.gov (United States)

    Khan, M. Ijaz; Zia, Q. M. Zaigham; Alsaedi, A.; Hayat, T.

    2018-03-01

    This attempt explores stagnation point flow of second grade material towards an impermeable stretched cylinder. Non-Fourier heat flux and thermal stratification are considered. Thermal conductivity dependents upon temperature. Governing non-linear differential system is solved using homotopic procedure. Interval of convergence for the obtained series solutions is explicitly determined. Physical quantities of interest have been examined for the influential variables entering into the problems. It is examined that curvature parameter leads to an enhancement in velocity and temperature. Further temperature for non-Fourier heat flux model is less than Fourier's heat conduction law.

  15. MHD convective boundary layer slip flow and heat transfer over nonlinearly stretching cylinder embedded in a thermally stratified medium

    Directory of Open Access Journals (Sweden)

    Muhammad Tamoor

    Full Text Available This article presents a numerical method of solution to laminar axisymmetric hydro magnetic flow of incompressible, electrically conducting and viscous fluid moving over the circular cylinder embedded in a thermally stratified medium. Fluid over the cylinder moves due to the stretching of cylindrical surface. Different physical conditions at the boundary are also considered. With the help of suitable similarity transformation the boundary layer equations are transformed into ordinary differential equations. The resulting nonlinear ordinary differential equations were solved by Runge-Kutta technique with shooting method. Obtained numerical results for different pertinent parameters are graphically shown for velocity distribution and temperature distribution. Due to the industrial applications point of view, it is evaluated that local Nusselt number at the surfaces increases due to the influence of thermal stratification. The skin-friction and heat transfer coefficients have presented in the form of table. Comparison of heat transfer coefficient is also illustrated. Keywords: Shooting method, Thermal stratification, Suction/blowing, Magneto hydrodynamic

  16. Process fluid cooling system

    International Nuclear Information System (INIS)

    Farquhar, N.G.; Schwab, J.A.

    1977-01-01

    A system of heat exchangers is disclosed for cooling process fluids. The system is particularly applicable to cooling steam generator blowdown fluid in a nuclear plant prior to chemical purification of the fluid in which it minimizes the potential of boiling of the plant cooling water which cools the blowdown fluid

  17. Fluid mechanics in fluids at rest.

    Science.gov (United States)

    Brenner, Howard

    2012-07-01

    Using readily available experimental thermophoretic particle-velocity data it is shown, contrary to current teachings, that for the case of compressible flows independent dye- and particle-tracer velocity measurements of the local fluid velocity at a point in a flowing fluid do not generally result in the same fluid velocity measure. Rather, tracer-velocity equality holds only for incompressible flows. For compressible fluids, each type of tracer is shown to monitor a fundamentally different fluid velocity, with (i) a dye (or any other such molecular-tagging scheme) measuring the fluid's mass velocity v appearing in the continuity equation and (ii) a small, physicochemically and thermally inert, macroscopic (i.e., non-Brownian), solid particle measuring the fluid's volume velocity v(v). The term "compressibility" as used here includes not only pressure effects on density, but also temperature effects thereon. (For example, owing to a liquid's generally nonzero isobaric coefficient of thermal expansion, nonisothermal liquid flows are to be regarded as compressible despite the general perception of liquids as being incompressible.) Recognition of the fact that two independent fluid velocities, mass- and volume-based, are formally required to model continuum fluid behavior impacts on the foundations of contemporary (monovelocity) fluid mechanics. Included therein are the Navier-Stokes-Fourier equations, which are now seen to apply only to incompressible fluids (a fact well-known, empirically, to experimental gas kineticists). The findings of a difference in tracer velocities heralds the introduction into fluid mechanics of a general bipartite theory of fluid mechanics, bivelocity hydrodynamics [Brenner, Int. J. Eng. Sci. 54, 67 (2012)], differing from conventional hydrodynamics in situations entailing compressible flows and reducing to conventional hydrodynamics when the flow is incompressible, while being applicable to both liquids and gases.

  18. Videotapes and Movies on Fluid Dynamics and Fluid Machines

    OpenAIRE

    Carr, Bobbie; Young, Virginia E.

    1996-01-01

    Chapter 17 of Handbook of Fluid Dynamics and Fluid Machinery: Experimental and Computational Fluid Dynamics, Volume 11. A list of videorecordings and 16mm motion pictures about Fluid Dynamics and Fluid Machines.

  19. Exploration of Fluid Dynamics in Perioperative Patients Using Bioimpedance Analysis.

    Science.gov (United States)

    Chong, Jae Uk; Nam, Sangguen; Kim, Hee Jung; Lee, Rami; Choi, Yunjung; Lee, Jae Gil; Kim, Kyung Sik

    2016-05-01

    Perioperative fluid restriction is advocated to reduce complications after major surgeries. Current methods of monitoring body fluids rely on indirect volume markers that may at times be inadequate. In our study, bioimpedance analysis (BIA) was used to explore fluid dynamics, in terms of intercompartmental shift, of perioperative patients undergoing operation for hepato-pancreato-biliary (HPB) diseases. A retrospective review was conducted, examining 36 patients surgically treated for HPB diseases between March 2010 and August 2012. Body fluid compartments were estimated via BIA at baseline (1 day prior to surgery), immediately after surgery, and on postoperative day 1, recording fluid balance during and after procedures. Patients were stratified by net fluid status as balanced (≤500 mL) or imbalanced (>550 mL) and outcomes of BIA compared. Mean net fluid balance volumes in balanced (n = 16) and imbalanced (n = 20) patient subsets were 231.41 ± 155.44 and 1050.18 ± 548.77 mL, respectively. Total body water (TBW) (p = 0.091), extracellular water (ECW) (p = 0.125), ECW/TBW (p = 0.740), and intracellular water (ICW) (p = 0.173) did not fluctuate significantly in fluid-balanced patients. Although TBW (p = 0.069) in fluid-imbalanced patients did not change significantly (relative to baseline), ECW (p = 0.001), ECW/TBW (p = 0.019), and ICW (p = 0.012) showed significant postoperative increases. The exploration of fluid dynamics using BIA has shown importance of balanced fluid management during perioperative period. Increased ECW/TBW in fluid-imbalanced patients suggests possible causality for the development of ascites or fluid collections during postoperative period in patients undergoing HPB operations.

  20. Experimental Validation of a Domestic Stratified Hot Water Tank Model in Modelica for Annual Performance Assessment

    DEFF Research Database (Denmark)

    Carmo, Carolina; Dumont, Olivier; Nielsen, Mads Pagh

    2015-01-01

    The use of stratified hot water tanks in solar energy systems - including ORC systems - as well as heat pump systems is paramount for a better performance of these systems. However, the availability of effective and reliable models to predict the annual performance of stratified hot water tanks...... coupled with energy system solutions is limited. In this poster, a discretized model of a stratified tank developed in Modelica is presented. The physical phenoma to be considered are the thermal transfers by conduction and convection – stratification, heat loss to ambient, charging and discharging...

  1. XXII Fluid Mechanics Conference (KKMP2016)

    International Nuclear Information System (INIS)

    2016-01-01

    to aerodynamics, atmospheric science, bio-fluids, combustion and reacting flows, computational fluid dynamics, experimental fluid mechanics, flow machinery, general fluid dynamics, hydromechanics, heat and fluid flow, measurement techniques, micro- and nano-flow, multi-phase flow, non-Newtonian fluids, rotating and stratified flows and turbulence. Within the general subjects of this conference, the Professor Janusz W. Eisner's Competition for the best fluid mechanics paper presented during the Conference is organized. Authors holding a M.Sc. or a Ph.D. degree and who are not older than 35 may enter the Competition. Authors with a Ph.D. degree must present individual papers; authors with a M.Sc. degree may present papers with their supervisors as coauthors, including original results of experimental, numerical or analytic research. Six state-of-the-art keynote papers will be delivered by world leading experts. All contributed papers were peer reviewed. Recommendations were received from the Scientific Committee of the Conference; reviewers were from all Polish scientific-academic centres that are involved in fluid mechanics. Accordingly, of the 67 eligible extended abstracts submitted, after a review process by the Scientific Committee, all papers were selected for presentation at XXII Fluid Mechanics Conference. We hope that this publication will be used not only as a guide through the conference's programme but also help in the future to access people and topics in fluid mechanics research. (paper)

  2. Numerical analysis of interfacial growth and deformation in horizontal stratified two-phase flow by lattice Boltzmann method

    International Nuclear Information System (INIS)

    Ebihara, Ken-ichi

    2005-03-01

    paper, first, the validity and the usefulness of the lattice-gas model and the lattice Boltzmann method for the numerical analysis of two-phase flow are examined by applying the two-phase fluid model of these methods to the phenomena of the falling droplet and the rising bubble. Next, on the basis of the examination of its numerical results, the horizontal stratified two-phase flow, which is the fundamental and important flow and often observed in a practical situation, is simulated by use of the HCZ model that is the two-phase fluid model of the lattice Boltzmann method proposed by He, Chen, and Zhang. The HCZ model can simulate Rayleigh-Taylor instability which shows complex interfacial phenomena. It is verified that the simulated interfacial growth is subject to the Kelvin-Helmholtz instability theory and can reproduce the curve concerning the interfacial growth of the theoretical flow regime map proposed by Taitel and Dukler (T-D map). Furthermore, it is found that the interfacial growth in the channel with the narrow width needs more superficial flow velocity than that given by the T-D map. In the simulation of the droplet generation in the horizontal stratified two-phase flow, it is verified that the HCZ model can also reproduce the experimental correlation proposed by Ishii and Grolmes within the range of the distribution of experimental data. According to the results of this report, it is found that the HCZ model of the lattice Boltzmann method can simulate complex interfacial phenomena in the horizontal stratified two-phase flow and reproduce the theoretical flow regime map and the experimental correlation. Considering the application of this model to more practical two-phase flow, it is also seen that this model has some problems which have to be solved, such as practical density difference, thermal influence and so on. (author)

  3. NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I

    International Nuclear Information System (INIS)

    Lacoste, J.; Cohen, L.; Hiscott, J.

    1991-01-01

    The effect of constitutive Tax expression on the interaction of NF-κ B with its recognition sequence and on NF-κ B-dependent gene expression was examined in T lymphoid Jurkat cell lines (19D and 9J) stably transformed with a Tax expression vector. Tax expressing T cell lines contained a constitutive level of NF-κ B binding activity, detectable by mobility shift assay and uv cross-linking using a palindromic NF-κ B probe homologous to the interferon beta PRDII site. In Jurkat and NC2.10 induction with phorbol esters resulted in the appearance of new DNA binding proteins of 85, 75, and 54 kDa, whereas in Tax expressing cells the 85-kDa protein and a 92-kDa DNA binding protein were constitutively induced. Expression of Tax protein in 19D and 9J resulted in transcription of the endogenous NF-kappa B-dependent granulocyte-macrophage colony stimulating factor gene and increased basal level expression of transfected NF-kappa B-regulated promoters. Nonetheless transcription of both the endogenous and the transfected gene was inducible by PMA treatment. Tax expression in Jurkat T cells may alter the stoichiometry of NF-kappa B DNA binding proteins and thus change the expression of NF-kappa B-regulated promoters

  4. Double-Stranded Linear Duck Hepatitis B Virus (DHBV) Stably Integrates at a Higher Frequency than Wild-Type DHBV in LMH Chicken Hepatoma Cells

    Science.gov (United States)

    Gong, Shih S.; Jensen, Anne D.; Chang, C. J.; Rogler, Charles E.

    1999-01-01

    Integration of hepadnavirus DNAs into host chromosomes can have oncogenic consequences. Analysis of host-viral DNA junctions of DHBV identified the terminally duplicated r region of the viral genome as a hotspot for integration. Since the r region is present on the 5′ and 3′ ends of double-stranded linear (DSL) hepadnavirus DNAs, these molecules have been implicated as integration precursors. We have produced a LMH chicken hepatoma cell line (LMH 66-1 DSL) which replicates exclusively DSL duck hepatitis B virus (DHBV) DNA. To test whether linear DHBV DNAs integrate more frequently than the wild type open circular DHBV DNAs, we have characterized the integration frequency in LMH 66-1 DSL cells by using a subcloning approach. This approach revealed that 83% of the LMH 66-1 DSL subclones contained new integrations, compared to only 16% of subclones from LMH-D2 cells replicating wild-type open circular DHBV DNA. Also, a higher percentage of the LMH 66-1 DSL subclones contained two or more new integrations. Mathematical analysis suggests that the DSL DHBV DNAs integrated stably once every three generations during subcloning whereas wild-type DHBV integrated only once every four to five generations. Cloning and sequencing of new integrations confirmed the r region as a preferred integration site for linear DHBV DNA molecules. One DHBV integrant was associated with a small deletion of chromosomal DNA, and another DHBV integrant occurred in a telomeric repeat sequence. PMID:9882355

  5. Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport.

    Science.gov (United States)

    Maares, Maria; Keil, Claudia; Thomsen, Susanne; Günzel, Dorothee; Wiesner, Burkhard; Haase, Hajo

    2018-01-29

    Intestinal zinc resorption, in particular its regulation and mechanisms, are not yet fully understood. Suitable intestinal cell models are needed to investigate zinc uptake kinetics and the role of labile zinc in enterocytes in vitro. Therefore, a Caco-2 cell clone was produced, stably expressing the genetically encoded zinc biosensor eCalwy-5. The aim of the present study was to reassure the presence of characteristic enterocyte-specific properties in the Caco-2-eCalwy clone. Comparison of Caco-2-WT and Caco-2-eCalwy cells revealed only slight differences regarding subcellular localization of the tight junction protein occludin and alkaline phosphatase activity, which did not affect basic integrity of the intestinal barrier or the characteristic brush border membrane morphology. Furthermore, introduction of the additional zinc-binding protein in Caco-2 cells did not alter mRNA expression of the major intestinal zinc transporters (zip4, zip5, znt-1 and znt-5), but increased metallothionein 1a-expression and cellular resistance to higher zinc concentrations. Moreover, this study examines the effect of sensor expression level on its saturation with zinc. Fluorescence cell imaging indicated considerable intercellular heterogeneity in biosensor-expression. However, FRET-measurements confirmed that these differences in expression levels have no effect on fractional zinc-saturation of the probe. Copyright © 2018 Elsevier GmbH. All rights reserved.

  6. Microfibrillated cellulose sheets coating oxygen-permeable PDMS membranes induce rat hepatocytes 3D aggregation into stably-attached 3D hemispheroids.

    Science.gov (United States)

    Evenou, Fanny; Couderc, Sandrine; Kim, Beomjoon; Fujii, Teruo; Sakai, Yasuyuki

    2011-01-01

    Here we report the use of natural, chemically-unmodified, microfibrillated cellulose (MFC) as a matrix for hepatocyte culture. We developed an original cell-culture design composed of a thin 3D-microstructured fibrous substrate consisting of a MFC sheet coating a highly O(2)-permeable polydimethylsiloxane (PDMS) membrane. The MFC-coated PDMS membranes were obtained according to a simple process where cellulose fibres were deposited from an aqueous suspension on the PDMS surfaces and the films were dried under mild conditions. To enable oxygen diffusion through the membranes, they were assembled on bottomless frames ('O(2)+' condition). Rat hepatocytes primary-cultured on such MFC-PDMS membranes quickly organized themselves into large hemispherical 3D aggregates which were tightly anchored to the MFC sheets. In contrast, hepatocytes cultured on smooth PDMS membranes in the O(2)+ system (O(2)+, PDMS) organized into unstable 2D monolayers which easily detached from the surfaces. Hepatocyte 3D cultures obtained on MFC-PDMS membranes exhibited higher liver-specific functions over a 2-week culture period, as assessed by both the higher albumin secretion and urea synthesis rate. The MFC-PDMS membranes appear suitable for obtaining stably-attached and functional hepatocyte 3D cultures and appear interesting for drug/chemical screenings in a microplate format, but also for microfluidic applications.

  7. Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein.

    Science.gov (United States)

    Vőfély, Gergő; Berecz, Tünde; Szabó, Eszter; Szebényi, Kornélia; Hathy, Edit; Orbán, Tamás I; Sarkadi, Balázs; Homolya, László; Marchetto, Maria C; Réthelyi, János M; Apáti, Ágota

    2018-04-01

    Pluripotent stem cell derived human neuronal progenitor cells (hPSC-NPCs) and their mature neuronal cell culture derivatives may efficiently be used for central nervous system (CNS) drug screening, including the investigation of ligand-induced calcium signalization. We have established hippocampal NPC cultures derived from human induced PSCs, which were previously generated by non-integrating Sendai virus reprogramming. Using established protocols these NPCs were differentiated into hippocampal dentate gyrus neurons. In order to study calcium signaling without the need of dye loading, we have stably expressed an advanced calcium indicator protein (GCaMP6fast) in the NPCs using the Sleeping Beauty transposon system. We observed no significant effects of the long-term GCaMP6 expression on NPC morphology, gene expression pattern or neural differentiation capacity. In order to compare the functional properties of GCaMP6-expressing neural cells and the corresponding parental cells loaded with calcium indicator dye Fluo-4, a detailed characterization of calcium signals was performed. We found that the calcium signals induced by ATP, glutamate, LPA, or proteases - were similar in these two systems. Moreover, the presence of the calcium indicator protein allowed for a sensitive, repeatable detection of changes in calcium signaling during the process of neurogenesis and neuronal maturation. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Pharmacological and functional characterisation of the wild-type and site-directed mutants of the human H1 histamine receptor stably expressed in CHO cells.

    Science.gov (United States)

    Moguilevsky, N; Varsalona, F; Guillaume, J P; Noyer, M; Gillard, M; Daliers, J; Henichart, J P; Bollen, A

    1995-01-01

    A cDNA clone for the human histamine H1 receptor was isolated from a lung cDNA library and stably expressed in CHO cells. The recombinant receptor protein present in the cell membranes, displayed the functional and binding characteristics of histamine H1 receptors. Mutation of Ser155 to Ala in the fourth transmembrane domain did not significantly change the affinity of the receptor for histamine and H1 antagonists. However, mutation of the fifth transmembrane Asn198 to Ala resulted in a dramatic decrease of the affinity for histamine binding, and for the histamine-induced polyphosphoinositides breakdown, whereas the affinity towards antagonists was not significantly modified. In addition, mutation of another fifth transmembrane amino acid, Thr194 to Ala also diminished, but to a lesser extent, the affinity for histamine. These data led us to propose a molecular model for histamine interaction with the human H1 receptor. In this model, the amide moiety of Asn198 and the hydroxyl group of Thr194 are involved in hydrogen bonding with the nitrogen atoms of the imidazole ring of histamine. Moreover, mutation of Thr194 to Ala demonstrated that this residue is responsible for the discrimination between enantiomers of cetirizine.

  9. Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor

    DEFF Research Database (Denmark)

    Pedersen, U B; Norby, B; Jensen, Anders A.

    1994-01-01

    Human dopamine D1a and D1b receptors were stably expressed in Baby Hamster Kidney (BHK) or Chinese Hamster Ovary (CHO) cells. [3H]SCH23390 saturation experiments indicated the presence of only a single binding site in the D1a expressing cell line with a Kd of 0.5 nM. In D1b expressing cell lines......, two binding sites were observed with Kd values of 0.5 and 5 nM in CHO cells and 0.05 and 1.6 nM in BHK cells, respectively. Neither of the receptors affected Ca2+ metabolism whereas they both were coupled in a stimulatory fashion to adenylyl cyclase. The pharmacological profile of both the D1a and D1b...... for these receptors. Besides SCH 23390, only NNC 112, fluphenazine and bulbocapnine were able to discriminate between the two states of the D1b receptor. In case of the D1a receptor, the Ki values obtained in binding experiments were very similar to Ki values obtained from inhibition of dopamine stimulated adenylyl...

  10. HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter.

    Directory of Open Access Journals (Sweden)

    Saifur Rahman

    Full Text Available RNA interference (RNAi is a natural cellular mechanism to silence gene expression and is predominantly mediated by microRNAs (miRNAs that target messenger RNA. Viruses can manipulate the cellular processes necessary for their replication by targeting the host RNAi machinery. This study explores the effect of human T-cell leukemia virus type 1 (HTLV-1 transactivating protein Tax on the RNAi pathway in the context of a chromosomally integrated viral long terminal repeat (LTR using a CD4(+ T-cell line, Jurkat. Transcription factor profiling of the HTLV-1 LTR stably integrated T-cell clone transfected with Tax demonstrates increased activation of substrates and factors associated with chromatin remodeling complexes. Using a miRNA microarray and bioinformatics experimental approach, Tax was also shown to downregulate the expression of miRNAs associated with the translational regulation of factors required for chromatin remodeling. These observations were validated with selected miRNAs and an HTLV-1 infected T cells line, MT-2. miR-149 and miR-873 were found to be capable of directly targeting p300 and p/CAF, chromatin remodeling factors known to play critical role in HTLV-1 pathogenesis. Overall, these results are first in line establishing HTLV-1/Tax-miRNA-chromatin concept and open new avenues toward understanding retroviral latency and/or replication in a given cell type.

  11. Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells

    Directory of Open Access Journals (Sweden)

    Jan Zitzmann

    2018-03-01

    Full Text Available The production of recombinant proteins in bioreactors requires real-time process monitoring and control to increase process efficiency and to meet the requirements for a comprehensive audit trail. The combination of optical near-infrared turbidity sensors and dielectric spectroscopy provides diverse system information because different measurement principles are exploited. We used this combination of techniques to monitor and control the growth and protein production of stably transformed Drosophila melanogaster S2 cells expressing antimicrobial proteins. The in situ monitoring system was suitable in batch, fed-batch and perfusion modes, and was particularly useful for the online determination of cell concentration, specific growth rate (µ and cell viability. These data were used to pinpoint the optimal timing of the key transitional events (induction and harvest during batch and fed-batch cultivation, achieving a total protein yield of ~25 mg at the 1-L scale. During cultivation in perfusion mode, the OD880 signal was used to control the bleed line in order to maintain a constant cell concentration of 5 × 107 cells/mL, thus establishing a turbidostat/permittistat culture. With this setup, a five-fold increase in productivity was achieved and 130 mg of protein was recovered after 2 days of induced perfusion. Our results demonstrate that both sensors are suitable for advanced monitoring and integration into online control strategies.

  12. Economic viability of Stratified Medicine concepts : An investor perspective on drivers and conditions that favour using Stratified Medicine approaches in a cost-contained healthcare environment

    NARCIS (Netherlands)

    Fugel, Hans-Joerg; Nuijten, Mark; Postma, Maarten

    2016-01-01

    RATIONALE: Stratified Medicine (SM) is becoming a natural result of advances in biomedical science and a promising path for the innovation-based biopharmaceutical industry to create new investment opportunities. While the use of biomarkers to improve R&D efficiency and productivity is very much

  13. Mathematical models for two-phase stratified pipe flow

    Energy Technology Data Exchange (ETDEWEB)

    Biberg, Dag

    2005-06-01

    . A 5 point resolution in each parameter would thus require 5{sup 13} =1.220.703.125 measurements. Field predictions generally involve model extrapolations. Flow models should therefore be given the best possible mechanistic basis in order to maximize their extrapolation potential. Multiphase pipe flow is a 3-D phenomenon. Flow models should thus ideally be based on a 3-D flow description. 3-D models do not contain many of the inconsistencies associated with traditional correlation based 1-D models, and do thus represent a higher extrapolation potential. The application of conventional 3-D CFD models for field predictions is limited by computer capacity. Evaluation speed is, however, not the only problem. 3-D CFD models remain to be subject to the closure issues and data tuning associated with turbulent flow models in general. They will thus not automatically yield correct flow predictions. The most pressing obstacle towards obtaining more reliable multiphase pipe flow predictions seems to be given by the closure issues related to the complex interaction of the fluids at the interface. No sufficiently general solution to this problem seems to be available at present. Closure issues could in theory be avoided by use of a direct numerical simulation of the governing equations (DNS). The seemingly insurmountable technical difficulties associated with the application of this approach for multiphase pipe flow field predictions do, however, render it out of reach at present. DNS may, however, serve as a numerical lab investigating model closure in less complicated models.

  14. On the embedding of convex spaces in stratified L-convex spaces.

    Science.gov (United States)

    Jin, Qiu; Li, Lingqiang

    2016-01-01

    Consider L being a continuous lattice, two functors from the category of convex spaces (denoted by CS) to the category of stratified L-convex spaces (denoted by SL-CS) are defined. The first functor enables us to prove that the category CS can be embedded in the category SL-CS as a reflective subcategory. The second functor enables us to prove that the category CS can be embedded in the category SL-CS as a coreflective subcategory when L satisfying a multiplicative condition. By comparing the two functors and the well known Lowen functor (between topological spaces and stratified L-topological spaces), we exhibit the difference between (stratified L-)topological spaces and (stratified L-)convex spaces.

  15. Forest resource inventory assessment in Gunung Rara Forest Reserve, Sabah, using stratified field sampling

    Science.gov (United States)

    Kamaruzaman Jusoff

    2000-01-01

    The objective of this paper is to assess the current timber volume by stratified sampling on a proposed plantation area. The study area is located in Gunung Rara Forest Reserve in the district of Tawau, Sabah, Malaysia.

  16. FOREWORD Fluid Mechanics and Fluid Power (FMFP)

    Indian Academy of Sciences (India)

    This section of the Special Issue carries selected articles from the Fluid Mechanics and Fluid. Power Conference held during 12–14 December 2013 at the National Institute of Technology,. Hamirpur (HP). The section includes three review articles and nine original research articles. These were selected on the basis of their ...

  17. Gravity Wave Emission by Spontaneous Imbalance of Baroclinic Waves in the Continuously Stratified Rotating Annulus

    Science.gov (United States)

    Borchert, Sebastian; Achatz, Ulrich; Rieper, Felix; Fruman, Mark

    2013-04-01

    We use a numerical model of the classic differentially heated rotating annulus experiment to study the spontaneous emission of gravity waves (GWs) from jet stream imbalances, which is a major source of these waves in the atmosphere for which no satisfactory parameterization exists. Atmospheric observations are the main tool for the testing and verification of theoretical concepts but have their limitations. Given their specific potential for yielding reproducible data and for studying process dependence on external system parameters, laboratory experiments are an invaluable complementary tool. Experiments with a rotating annulus exhibiting a jet modulated by large-scale waves due to baroclinic instability have already been used to study GWs: Williams et al (2008) observed spontaneously emitted interfacial GWs in a two-layer flow, and Jacoby et al (2011) detected GWs emitted from boundary-layer instabilities in a differentially heated rotating annulus. Employing a finite-volume code for the numerical simulation of a continuously stratified liquid in a differentially heated rotating annulus, we here investigate the GWs in a wide and shallow annulus with relatively large temperature difference between inner and outer cylinder walls. In this atmosphere-like regime where the Brunt-Vaisala frequency is larger than the inertial frequency, various analyses suggest a distinct gravity wave activity. To identify regions of GW emission we decompose the flow into the geostrophic and ageostrophic part through the inversion of the quasi-geostrophic potential vorticity (e.g. Verkley, 2009). The analysis of the geostrophic sources of the ageostrophic flow indicates that, in addition to boundary layer instabilities, spontaneous imbalance in the jet region acts as an important source mechanism. Jacoby, T. N. L., Read, P. L., Williams, P. D. and Young, R. M. B., 2011: Generation of inertia-gravity waves in the rotating thermal annulus by a localised boundary layer instability. Geophys

  18. Electric fluid pump

    Science.gov (United States)

    Van Dam, Jeremy Daniel; Turnquist, Norman Arnold; Raminosoa, Tsarafidy; Shah, Manoj Ramprasad; Shen, Xiaochun

    2015-09-29

    An electric machine is presented. The electric machine includes a hollow rotor; and a stator disposed within the hollow rotor, the stator defining a flow channel. The hollow rotor includes a first end portion defining a fluid inlet, a second end portion defining a fluid outlet; the fluid inlet, the fluid outlet, and the flow channel of the stator being configured to allow passage of a fluid from the fluid inlet to the fluid outlet via the flow channel; and wherein the hollow rotor is characterized by a largest cross-sectional area of hollow rotor, and wherein the flow channel is characterized by a smallest cross-sectional area of the flow channel, wherein the smallest cross-sectional area of the flow channel is at least about 25% of the largest cross-sectional area of the hollow rotor. An electric fluid pump and a power generation system are also presented.

  19. Hydraulic Brake Fluid,

    Science.gov (United States)

    A hydraulic brake fluid consisting of diethylene glycol , monoethyl ether of diethylene glycol , and castor oil has been improved as described in the patent by adding the fluid tributyl ether of orthophosphoric acid.

  20. Lectures on fluid mechanics

    CERN Document Server

    Shinbrot, Marvin

    2012-01-01

    Readable and user-friendly, this high-level introduction explores the derivation of the equations of fluid motion from statistical mechanics, classical theory, and a portion of the modern mathematical theory of viscous, incompressible fluids. 1973 edition.

  1. Pleural fluid Gram stain

    Science.gov (United States)

    Gram stain of pleural fluid ... mixing it with a violet stain (called a Gram stain). A laboratory specialist uses a microscope to ... reveals an abnormal collection of pleural fluid. The Gram stain can help identify the bacteria that might ...

  2. Computational Fluid Dynamics

    International Nuclear Information System (INIS)

    Myeong, Hyeon Guk

    1999-06-01

    This book deals with computational fluid dynamics with basic and history of numerical fluid dynamics, introduction of finite volume method using one-dimensional heat conduction equation, solution of two-dimensional heat conduction equation, solution of Navier-Stokes equation, fluid with heat transport, turbulent flow and turbulent model, Navier-Stokes solution by generalized coordinate system such as coordinate conversion, conversion of basic equation, program and example of calculation, application of abnormal problem and high speed solution of numerical fluid dynamics.

  3. Fluid dynamic transient analysis

    International Nuclear Information System (INIS)

    Vilhena Reigosa, R. de

    1992-01-01

    This paper describes the methodology adopted at NUCLEN for the fluid dynamic analyses for ANGRA 2. The fluid dynamic analysis allows, through computer codes to simulate and quantify the loads resulting from fluid dynamic transients caused by postulated ruptures or operational transients, in the piping of the safety systems and of the important operational systems. (author)

  4. Amniotic fluid water dynamics

    NARCIS (Netherlands)

    Beall, M. H.; van den Wijngaard, J. P. H. M.; van Gemert, M. J. C.; Ross, M. G.

    2007-01-01

    Water arrives in the mammalian gestation from the maternal circulation across the placenta. It then circulates between the fetal water compartments, including the fetal body compartments, the placenta and the amniotic fluid. Amniotic fluid is created by the flow of fluid from the fetal lung and

  5. Fundamental Fluid Mechanics

    Indian Academy of Sciences (India)

    BOOK I REVIEW. Fundamental Fluid. Mechanics. Good Text Book Material. V H Arakeri. Fluid Mechanics for Engineers. P N Chatterjee. MacMillan India Limited. Vol. 1, pp. 367. RS.143. Vo1.2, pp.306. RS.130. Fluid Mechanics for Engineers in two vol- umes by P N Chatterjee contains standard material for a first level ...

  6. Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein.

    Science.gov (United States)

    Kang, Yu Jeong; Seo, Dae-Gun; Park, So-Young

    2016-11-01

    β-Amyloid (Aβ) is a substance of Alzheimer disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD. The methanol extract of cinnamon bark efficiently reduced Aβ40 production in Chinese hamster ovarian (CHO) cells stably expressing APP as determined by enzyme-linked immunosorbent assay. Bioassay-guided isolation of cinnamon bark extract was carried out using open column chromatography and high-performance liquid chromatography, and the following 6 phenylpropanoids were isolated: syringaresinol (1); medioresinol (2); coumarin (3); 2-hydroxycinnamaldehyde (4); cryptamygin A (5); and 3',5,7-trimethoxy epicatechin (6). Among these, 4 μg/mL medioresinol and cryptamygin A reduced Aβ40 production by 50% and 60%, respectively, compared with dimethyl sulfoxide-treated control cells. The IC 50 values of medioresinol and cryptamygin A for the inhibition of Aβ40 production were 10.8 and 8.2 μg/mL, respectively. Furthermore, treatment of APP-CHO cells with either compound decreased the amount of β-secretase and sAPPβ (the proteolytic fragment of APP catalyzed by β-secretase). These results suggest that the antiamyloidogenic activity of cinnamon bark extract was exerted by medioresinol and cryptamygin A via a reduction in the amount of β-secretase. The extract of cinnamon bark contains potentially valuable antiamyloidogenic agents for the prevention and treatment of AD. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.

    Science.gov (United States)

    Wang, Ging Kuo; Russell, Gabriella; Wang, Sho-Ya

    2013-01-01

    Miniature persistent late Na(+) currents in cardiomyocytes have been linked to arrhythmias and sudden death. The goals of this study are to establish a stable cell line expressing robust persistent cardiac Na(+) currents and to test Class 1 antiarrhythmic drugs for selective action against resting and open states. After transient transfection of an inactivation-deficient human cardiac Na(+) channel clone (hNav1.5-CW with L409C/A410W double mutations), transfected mammalian HEK293 cells were treated with 1 mg/ml G-418. Individual G-418-resistant colonies were isolated using glass cylinders. One colony with high expression of persistent Na(+) currents was subjected to a second colony selection. Cells from this colony remained stable in expressing robust peak Na(+) currents of 996 ± 173 pA/pF at +50 mV (n = 20). Persistent late Na(+) currents in these cells were clearly visible during a 4-second depolarizing pulse albeit decayed slowly. This slow decay is likely due to slow inactivation of Na(+) channels and could be largely eliminated by 5 μM batrachotoxin. Peak cardiac hNav1.5-CW Na(+) currents were blocked by tetrodotoxin with an IC(50) value of 2.27 ± 0.08 μM (n = 6). At clinic relevant concentrations, Class 1 antiarrhythmics are much more selective in blocking persistent late Na(+) currents than their peak counterparts, with a selectivity ratio ranging from 80.6 (flecainide) to 3 (disopyramide). We conclude that (1) Class 1 antiarrhythmics differ widely in their resting- vs. open-channel selectivity, and (2) stably transfected HEK293 cells expressing large persistent hNav1.5-CW Na(+) currents are suitable for studying as well as screening potent open-channel blockers.

  8. SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa Stably Transfected with SPARC.

    Directory of Open Access Journals (Sweden)

    Andrea Slusser-Nore

    Full Text Available This laboratory previously analyzed the expression of SPARC in the parental UROtsa cells, their arsenite (As(+3 and cadmium (Cd(+2-transformed cell lines, and tumor transplants generated from the transformed cells. It was demonstrated that SPARC expression was down-regulated to background levels in Cd(+2-and As(+3-transformed UROtsa cells and tumor transplants compared to parental cells. In the present study, the transformed cell lines were stably transfected with a SPARC expression vector to determine the effect of SPARC expression on the ability of the cells to form tumors in immune-compromised mice.Real time PCR, western blotting, immunohistochemistry, and immunofluorescence were used to define the expression of SPARC in the As(+3-and Cd(+2-transformed cell lines, and urospheres isolated from these cell lines, following their stable transfection with an expression vector containing the SPARC open reading frame (ORF. Transplantation of the cultured cells into immune-compromised mice by subcutaneous injection was used to assess the effect of SPARC expression on tumors generated from the above cell lines and urospheres.It was shown that the As(+3-and Cd(+2-transformed UROtsa cells could undergo stable transfection with a SPARC expression vector and that the transfected cells expressed both SPARC mRNA and secreted protein. Tumors formed from these SPARC-transfected cells were shown to have no expression of SPARC. Urospheres isolated from cultures of the SPARC-transfected As(+3-and Cd(+2-transformed cell lines were shown to have only background expression of SPARC. Urospheres from both the non-transfected and SPARC-transfected cell lines were tumorigenic and thus fit the definition for a population of tumor initiating cells.Tumor initiating cells isolated from SPARC-transfected As(+3-and Cd(+2-transformed cell lines have an inherent mechanism to suppress the expression of SPARC mRNA.

  9. DEAD-box helicase DDX27 regulates 3′ end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

    Energy Technology Data Exchange (ETDEWEB)

    Kellner, Markus; Rohrmoser, Michaela [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany); Forné, Ignasi [Adolf Butenandt Institute, Ludwig Maximilians University of Munich, Center for Integrated Protein Science Munich (CIPSM), Schillerstr. 44, Munich 80336 (Germany); Voss, Kirsten; Burger, Kaspar; Mühl, Bastian; Gruber-Eber, Anita [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany); Kremmer, Elisabeth [Institute of Molecular Immunology, Helmholtz Center Munich, Marchioninistr. 25, Munich 81377 (Germany); Imhof, Axel [Adolf Butenandt Institute, Ludwig Maximilians University of Munich, Center for Integrated Protein Science Munich (CIPSM), Schillerstr. 44, Munich 80336 (Germany); Eick, Dirk, E-mail: eick@helmholtz-muenchen.de [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany)

    2015-05-15

    PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex. DDX27 interacts with the PeBoW-complex via an evolutionary conserved F×F motif in the N-terminal domain and is recruited to the nucleolus via its basic C-terminal domain. This recruitment is RNA-dependent and occurs independently of the PeBoW-complex. Interestingly, knockdown of DDX27, but not of Pes1, induces the accumulation of an extended form of the primary 47S rRNA. We conclude that DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3′ end formation of 47S rRNA independently of the PeBoW-complex. - Highlights: • DEAD-box helicase DDX27 is a new constituent of the PeBoW-complex. • The N-terminal F×F motif of DDX27 interacts with the PeBoW components Pes1 and Bop1. • Nucleolar anchoring of DDX27 via its basic C-terminal domain is RNA dependent. • Knockdown of DDX27 induces a specific defect in 3′ end formation of 47S rRNA.

  10. Working Memory Capacity and Fluid Intelligence: Maintenance and Disengagement.

    Science.gov (United States)

    Shipstead, Zach; Harrison, Tyler L; Engle, Randall W

    2016-11-01

    Working memory capacity and fluid intelligence have been demonstrated to be strongly correlated traits. Typically, high working memory capacity is believed to facilitate reasoning through accurate maintenance of relevant information. In this article, we present a proposal reframing this issue, such that tests of working memory capacity and fluid intelligence are seen as measuring complementary processes that facilitate complex cognition. Respectively, these are the ability to maintain access to critical information and the ability to disengage from or block outdated information. In the realm of problem solving, high working memory capacity allows a person to represent and maintain a problem accurately and stably, so that hypothesis testing can be conducted. However, as hypotheses are disproven or become untenable, disengaging from outdated problem solving attempts becomes important so that new hypotheses can be generated and tested. From this perspective, the strong correlation between working memory capacity and fluid intelligence is due not to one ability having a causal influence on the other but to separate attention-demanding mental functions that can be contrary to one another but are organized around top-down processing goals. © The Author(s) 2016.

  11. Fluid and particle mechanics

    CERN Document Server

    Michell, S J

    2013-01-01

    Fluid and Particle Mechanics provides information pertinent to hydraulics or fluid mechanics. This book discusses the properties and behavior of liquids and gases in motion and at rest. Organized into nine chapters, this book begins with an overview of the science of fluid mechanics that is subdivided accordingly into two main branches, namely, fluid statics and fluid dynamics. This text then examines the flowmeter devices used for the measurement of flow of liquids and gases. Other chapters consider the principle of resistance in open channel flow, which is based on improper application of th

  12. Fluid inclusion geothermometry

    Science.gov (United States)

    Cunningham, C.G.

    1977-01-01

    Fluid inclusions trapped within crystals either during growth or at a later time provide many clues to the histories of rocks and ores. Estimates of fluid-inclusion homogenization temperature and density can be obtained using a petrographic microscope with thin sections, and they can be refined using heating and freezing stages. Fluid inclusion studies, used in conjunction with paragenetic studies, can provide direct data on the time and space variations of parameters such as temperature, pressure, density, and composition of fluids in geologic environments. Changes in these parameters directly affect the fugacity, composition, and pH of fluids, thus directly influencing localization of ore metals. ?? 1977 Ferdinand Enke Verlag Stuttgart.

  13. Modelling of vapour explosion in stratified geometrie; Modelisation de l'explosion de vapeur en geometrie stratifiee

    Energy Technology Data Exchange (ETDEWEB)

    Picchi, St

    1999-07-07

    When a hot liquid comes into contact with a colder volatile liquid, one can obtain in some conditions an explosive vaporization, told vapour explosion, whose consequences can be important on neighbouring structures. This explosion needs the intimate mixing and the fine fragmentation between the two liquids. In a stratified vapour explosion, these two liquids are initially superposed and separated by a vapor film. A triggering of the explosion can induce a propagation of this along the film. A study of experimental results and existent models has allowed to retain the following main points: - the explosion propagation is due to a pressure wave propagating through the medium; - the mixing is due to the development of Kelvin-Helmholtz instabilities induced by the shear velocity between the two liquids behind the pressure wave. The presence of the vapour in the volatile liquid explains experimental propagation velocity and the velocity difference between the two fluids at the pressure wave crossing. A first model has been proposed by Brayer in 1994 in order to describe the fragmentation and the mixing of the two fluids. Results of the author do not show explosion propagation. We have therefore built a new mixing-fragmentation model based on the atomization phenomenon that develops itself during the pressure wave crossing. We have also taken into account the transient aspect of the heat transfer between fuel drops and the volatile liquid, and elaborated a model of transient heat transfer. These two models have been introduced in a multi-components, thermal, hydraulic code, MC3D. Results of calculation show a qualitative and quantitative agreement with experimental results and confirm basic options of the model. (author)

  14. Electromagnetic scattering by two concentric spheres buried in a stratified material.

    Science.gov (United States)

    Frezza, F; Mangini, F; Tedeschi, N

    2015-02-01

    In this paper, a rigorous method to analyze the electromagnetic scattering of an elliptically polarized plane wave by two concentric spheres buried in a dielectric stratified medium is presented. The interaction of the electromagnetic radiation with the stratified material is taken into account by means of the transfer matrix approach, in this way we can consider the stratified medium as an effective single interface. All the electromagnetic fields are expanded in series of spherical vector harmonics. The transmitted field through the stratified medium is obtained by means of the effective transmission coefficient. This field is scattered by the two concentric spheres, and the scattered field interacts again with the stratified material. The scattered-reflected and scattered-transmitted fields by the layered medium are computed by exploiting the plane-wave spectrum of the scattered field, considering the reflection and transmission of each elementary plane wave by the effective interface. The boundary conditions imposition on the spheres' surfaces leads to a linear system that returns the unknown coefficients of the problem. A numerical code has been implemented to compute the field over all the space. In order to compute the scattered fields, a truncation criterion has been proposed for the numerical evaluation of the series. Finally, to validate the presented method, comparisons between the results of the proposed code and the results of simulations with a software based on the finite element method have been implemented, showing very good agreement.

  15. Risk score to stratify children with suspected serious bacterial infection: observational cohort study.

    Science.gov (United States)

    Brent, Andrew J; Lakhanpaul, Monica; Thompson, Matthew; Collier, Jacqueline; Ray, Samiran; Ninis, Nelly; Levin, Michael; MacFaul, Roddy

    2011-04-01

    To derive and validate a clinical score to risk stratify children presenting with acute infection. Observational cohort study of children presenting with suspected infection to an emergency department in England. Detailed data were collected prospectively on presenting clinical features, laboratory investigations and outcome. Clinical predictors of serious bacterial infection (SBI) were explored in multivariate logistic regression models using part of the dataset, each model was then validated in an independent part of the dataset, and the best model was chosen for derivation of a clinical risk score for SBI. The ability of this score to risk stratify children with SBI was then assessed in the entire dataset. Final diagnosis of SBI according to criteria defined by the Royal College of Paediatrics and Child Health working group on Recognising Acute Illness in Children. Data from 1951 children were analysed. 74 (3.8%) had SBI. The sensitivity of individual clinical signs was poor, although some were highly specific for SBI. A score was derived with reasonable ability to discriminate SBI (area under the receiver operator characteristics curve 0.77, 95% CI 0.71 to 0.83) and risk stratify children with suspected SBI. This study demonstrates the potential utility of a clinical score in risk stratifying children with suspected SBI. Further work should aim to validate the score and its impact on clinical decision making in different settings, and ideally incorporate it into a broader management algorithm including additional investigations to further stratify a child's risk.

  16. Spinning fluids reactor

    Science.gov (United States)

    Miller, Jan D; Hupka, Jan; Aranowski, Robert

    2012-11-20

    A spinning fluids reactor, includes a reactor body (24) having a circular cross-section and a fluid contactor screen (26) within the reactor body (24). The fluid contactor screen (26) having a plurality of apertures and a circular cross-section concentric with the reactor body (24) for a length thus forming an inner volume (28) bound by the fluid contactor screen (26) and an outer volume (30) bound by the reactor body (24) and the fluid contactor screen (26). A primary inlet (20) can be operatively connected to the reactor body (24) and can be configured to produce flow-through first spinning flow of a first fluid within the inner volume (28). A secondary inlet (22) can similarly be operatively connected to the reactor body (24) and can be configured to produce a second flow of a second fluid within the outer volume (30) which is optionally spinning.

  17. Intravenous fluids: balancing solutions.

    Science.gov (United States)

    Hoorn, Ewout J

    2017-08-01

    The topic of intravenous (IV) fluids may be regarded as "reverse nephrology", because nephrologists usually treat to remove fluids rather than to infuse them. However, because nephrology is deeply rooted in fluid, electrolyte, and acid-base balance, IV fluids belong in the realm of our specialty. The field of IV fluid therapy is in motion due to the increasing use of balanced crystalloids, partly fueled by the advent of new solutions. This review aims to capture these recent developments by critically evaluating the current evidence base. It will review both indications and complications of IV fluid therapy, including the characteristics of the currently available solutions. It will also cover the use of IV fluids in specific settings such as kidney transplantation and pediatrics. Finally, this review will address the pathogenesis of saline-induced hyperchloremic acidosis, its potential effect on outcomes, and the question if this should lead to a definitive switch to balanced solutions.

  18. Two-phase air-water stratified flow measurement using ultrasonic techniques

    International Nuclear Information System (INIS)

    Fan, Shiwei; Yan, Tinghu; Yeung, Hoi

    2014-01-01

    In this paper, a time resolved ultrasound system was developed for investigating two-phase air-water stratified flow. The hardware of the system includes a pulsed wave transducer, a pulser/receiver, and a digital oscilloscope. The time domain cross correlation method is used to calculate the velocity profile along ultrasonic beam. The system is able to provide velocities with spatial resolution of around 1mm and the temporal resolution of 200μs. Experiments were carried out on single phase water flow and two-phase air-water stratified flow. For single phase water flow, the flow rates from ultrasound system were compared with those from electromagnetic flow (EM) meter, which showed good agreement. Then, the experiments were conducted on two-phase air-water stratified flow and the results were given. Compared with liquid height measurement from conductance probe, it indicated that the measured velocities were explainable

  19. Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells

    Directory of Open Access Journals (Sweden)

    Taro Mikami

    2015-01-01

    Full Text Available BACKGROUND: The collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involved. Furthermore, whereas Rho family proteins, including RhoA, play important roles in cell migration, the exact role of Rho-associated coiled coil-containing protein kinases (ROCKs in cell migration is controversial and might be cell-type dependent. Here, we report the development of a novel modified scratch assay that was used to observe the collective cell migration of stratified TE-10 cells derived from a human esophageal cancer specimen. RESULTS: Desmosomes were found between the TE-10 cells and microvilli of the surface of the cell sheet. The leading edge of cells in the cell sheet formed a simple layer and moved forward regularly; these rows were followed by the stratified epithelium. ROCK inhibitors and ROCK small interfering RNAs (siRNAs disturbed not only the collective migration of the leading edge of this cell sheet, but also the stratified layer in the rear. In contrast, RhoA siRNA treatment resulted in more rapid migration of the leading rows and disturbed movement of the stratified portion. CONCLUSIONS: The data presented in this study suggest that ROCKs play an important role in mediating the collective migration of TE-10 cell sheets. In addition, differences between the effects of siRNAs targeting either RhoA or ROCKs suggested that distinct mechanisms regulate the collective cell migration in the simple epithelium of the wound edge versus the stratified layer of the epithelium.

  20. Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13.

    Science.gov (United States)

    Ji, Minghui; Zhang, Yudong; Li, Na; Wang, Chao; Xia, Rong; Zhang, Zhan; Wang, Shou-Lin

    2017-10-13

    Cytochrome P450 2A13 (CYP2A13), an extrahepatic enzyme mainly expressed in the human respiratory system, has been reported to mediate the metabolism and toxicity of cigarette smoke. We previously found that nicotine inhibited 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism by CYP2A13, but its influence on other components of cigarette smoke remains unclear. The nicotine component of cigarette smoke extract (CSE) was separated, purified, and identified using high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), splitting CSE into a nicotine section (CSE-N) and nicotine-free section (CSE-O). Cell viability and apoptosis by Cell Counting Kit-8 (CCK-8) and flow cytometry assays were conducted on immortalized human bronchial epithelial (BEAS-2B) cells stably expressing CYP2A13 (B-2A13) or vector (B-V), respectively. Interestingly, CSE and CSE-O were toxic to BEAS-2B cells whereas CSE-N showed less cytotoxicity. CSE-O was more toxic to B-2A13 cells than to B-V cells (IC 50 of 2.49% vs. 7.06%), which was flatted by 8-methoxypsoralen (8-MOP), a CYP inhibitor. CSE-O rather than CSE or CSE-N increased apoptosis of B-2A13 cells rather than B-V cells. Accordingly, compared to CSE-N and CSE, CSE-O significantly changed the expression of three pairs of pro- and anti-apoptotic proteins, Bcl-2 Associated X Protein/B cell lymphoma-2 (Bax/Bcl-2), Cleaved Poly (Adenosine Diphosphate-Ribose) Polymerase/Poly (Adenosine Diphosphate-Ribose) Polymerase (C-PARP/PARP), and C-caspase-3/caspase-3, in B-2A13 cells. In addition, recombination of CSE-N and CSE-O (CSE-O/N) showed similar cytotoxicity and apoptosis to the original CSE. These results demonstrate that the nicotine component decreases the metabolic activation of CYP2A13 to CSE and aids in understanding the critical role of CYP2A13 in human respiratory diseases caused by cigarette smoking.

  1. Experimental Observation of the Stratified Electrothermal Instability on Aluminum with Thickness Greater than a Skin Depth

    Energy Technology Data Exchange (ETDEWEB)

    Hutchinson, Trevor M. [Univ. of Nevada, Reno, NV (United States); Hutchinson, Trevor M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Awe, Thomas James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bauer, Bruno S. [Univ. of Nevada, Reno, NV (United States); Yates, Kevin [Univ. of New Mexico, Albuquerque, NM (United States); Yu, Edmund p. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yelton, William G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fuelling, Stephan [Univ. of Nevada, Reno, NV (United States)

    2017-07-01

    The first direct observation of the stratified electrothermal instability on the surface of thick metal is reported. Aluminum rods coated with 70 μm Parylene-N were driven to 1 MA in approximately 100 ns, with the metal thicker than the skin depth. The dielectric coating suppressed plasma formation, enabling persistent observation of discrete azimuthally-correlated stratified structures perpendicular to the current. Strata amplitudes grow rapidly, while their Fourier spectrum shifts toward longer wavelength. Assuming blackbody emission, radiometric calculations indicate strata are temperature perturbations that grow exponentially with rate γ = 0.04 ns -1 in 3000- 10,000 K aluminum.

  2. Unit Stratified Sampling as a Tool for Approximation of Stochastic Optimization Problems

    Czech Academy of Sciences Publication Activity Database

    Šmíd, Martin

    2012-01-01

    Roč. 19, č. 30 (2012), s. 153-169 ISSN 1212-074X R&D Projects: GA ČR GAP402/11/0150; GA ČR GAP402/10/0956; GA ČR GA402/09/0965 Institutional research plan: CEZ:AV0Z10750506 Institutional support: RVO:67985556 Keywords : Stochastic programming * approximation * stratified sampling Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2013/E/smid-unit stratified sampling as a tool for approximation of stochastic optimization problems.pdf

  3. Fiber optic fluid detector

    Science.gov (United States)

    Angel, S. Michael

    1989-01-01

    Particular gases or liquids are detected with a fiber optic element (11, 11a to 11j) having a cladding or coating of a material (23, 23a to 23j) which absorbs the fluid or fluids and which exhibits a change of an optical property, such as index of refraction, light transmissiveness or fluoresence emission, for example, in response to absorption of the fluid. The fluid is sensed by directing light into the fiber optic element and detecting changes in the light, such as exit angle changes for example, that result from the changed optical property of the coating material. The fluid detector (24, 24a to 24j) may be used for such purposes as sensing toxic or explosive gases in the atmosphere, measuring ground water contamination or monitoring fluid flows in industrial processes, among other uses.

  4. Metalworking and machining fluids

    Science.gov (United States)

    Erdemir, Ali; Sykora, Frank; Dorbeck, Mark

    2010-10-12

    Improved boron-based metal working and machining fluids. Boric acid and boron-based additives that, when mixed with certain carrier fluids, such as water, cellulose and/or cellulose derivatives, polyhydric alcohol, polyalkylene glycol, polyvinyl alcohol, starch, dextrin, in solid and/or solvated forms result in improved metalworking and machining of metallic work pieces. Fluids manufactured with boric acid or boron-based additives effectively reduce friction, prevent galling and severe wear problems on cutting and forming tools.

  5. Electrorheological fluids and methods

    Science.gov (United States)

    Green, Peter F.; McIntyre, Ernest C.

    2015-06-02

    Electrorheological fluids and methods include changes in liquid-like materials that can flow like milk and subsequently form solid-like structures under applied electric fields; e.g., about 1 kV/mm. Such fluids can be used in various ways as smart suspensions, including uses in automotive, defense, and civil engineering applications. Electrorheological fluids and methods include one or more polar molecule substituted polyhedral silsesquioxanes (e.g., sulfonated polyhedral silsesquioxanes) and one or more oils (e.g., silicone oil), where the fluid can be subjected to an electric field.

  6. Plasmas and fluids

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Plasma and fluid physics includes the fields of fusion research and space investigation. This book discusses the most important advances in these areas over the past decade and recommends a stronger commitment to basic research in plasma and fluid physics. The book recommends that plasma and fluid physics be included in physics curriculums because of their increasing importance in energy and defense. The book also lists recent accomplishments in the fields of general plasma physics, fusion plasma confinement and heating, space and astrophysical plasmas, and fluid physics and lists research opportunities in these areas. A funding summary explains how research monies are allocated and suggests ways to improve their effectiveness

  7. The Fluids RAP

    Science.gov (United States)

    Nedyalkov, Ivaylo

    2016-11-01

    After fifteen years of experience in rap, and ten in fluid mechanics, "I am coming here with high-Reynolds-number stamina; I can beat these rap folks whose flows are... laminar." The rap relates fluid flows to rap flows. The fluid concepts presented in the song have varying complexity and the listeners/viewers will be encouraged to read the explanations on a site dedicated to the rap. The music video will provide an opportunity to share high-quality fluid visualizations with a general audience. This talk will present the rap lyrics, the vision for the video, and the strategy for outreach. Suggestions and comments will be welcomed.

  8. Fluid dynamics transactions

    CERN Document Server

    Fiszdon, W

    1965-01-01

    Fluid Dynamics Transactions, Volume 2 compiles 46 papers on fluid dynamics, a subdiscipline of fluid mechanics that deals with fluid flow. The topics discussed in this book include developments in interference theory for aeronautical applications; diffusion from sources in a turbulent boundary layer; unsteady motion of a finite wing span in a compressible medium; and wall pressure covariance and comparison with experiment. The certain classes of non-stationary axially symmetric flows in magneto-gas-dynamics; description of the phenomenon of secondary flows in curved channels by means of co

  9. Sphere based fluid systems

    Science.gov (United States)

    Elleman, Daniel D. (Inventor); Wang, Taylor G. (Inventor)

    1989-01-01

    Systems are described for using multiple closely-packed spheres. In one system for passing fluid, a multiplicity of spheres lie within a container, with all of the spheres having the same outside diameter and with the spheres being closely nested in one another to create multiple interstitial passages of a known size and configuration and smooth walls. The container has an inlet and outlet for passing fluid through the interstitial passages formed between the nested spheres. The small interstitial passages can be used to filter out material, especially biological material such as cells in a fluid, where the cells can be easily destroyed if passed across sharp edges. The outer surface of the spheres can contain a material that absorbs a constitutent in the flowing fluid, such as a particular contamination gas, or can contain a catalyst to chemically react the fluid passing therethrough, the use of multiple small spheres assuring a large area of contact of these surfaces of the spheres with the fluid. In a system for storing and releasing a fluid such as hydrogen as a fuel, the spheres can include a hollow shell containing the fluid to be stored, and located within a compressable container that can be compressed to break the shells and release the stored fluid.

  10. Theoretical Fluid Dynamics

    CERN Document Server

    Shivamoggi, Bhimsen K

    1998-01-01

    "Although there are many texts and monographs on fluid dynamics, I do not know of any which is as comprehensive as the present book. It surveys nearly the entire field of classical fluid dynamics in an advanced, compact, and clear manner, and discusses the various conceptual and analytical models of fluid flow." - Foundations of Physics on the first edition. Theoretical Fluid Dynamics functions equally well as a graduate-level text and a professional reference. Steering a middle course between the empiricism of engineering and the abstractions of pure mathematics, the author focuses

  11. A novel method for calculating and measuring the second-order buoyancy experienced by a magnet immersed in magnetic fluid

    Science.gov (United States)

    Yu, Jun; Hao, Du; Li, Decai

    2018-01-01

    The phenomenon whereby an object whose density is greater than magnetic fluid can be suspended stably in magnetic fluid under the magnetic field is one of the peculiar properties of magnetic fluids. Examples of applications based on the peculiar properties of magnetic fluid are sensors and actuators, dampers, positioning systems and so on. Therefore, the calculation and measurement of magnetic levitation force of magnetic fluid is of vital importance. This paper concerns the peculiar second-order buoyancy experienced by a magnet immersed in magnetic fluid. The expression for calculating the second-order buoyancy was derived, and a novel method for calculating and measuring the second-order buoyancy was proposed based on the expression. The second-order buoyancy was calculated by ANSYS and measured experimentally using the novel method. To verify the novel method, the second-order buoyancy was measured experimentally with a nonmagnetic rod stuck on the top surface of the magnet. The results of calculations and experiments show that the novel method for calculating the second-order buoyancy is correct with high accuracy. In addition, the main causes of error were studied in this paper, including magnetic shielding of magnetic fluid and the movement of magnetic fluid in a nonuniform magnetic field.

  12. Measures to assess the prognostic ability of the stratified Cox proportional hazards model

    DEFF Research Database (Denmark)

    (Tybjaerg-Hansen, A.) The Fibrinogen Studies Collaboration.The Copenhagen City Heart Study; Tybjærg-Hansen, Anne

    2009-01-01

    Many measures have been proposed to summarize the prognostic ability of the Cox proportional hazards (CPH) survival model, although none is universally accepted for general use. By contrast, little work has been done to summarize the prognostic ability of the stratified CPH model; such measures...

  13. Study of stratified dielectric slab medium structures using pseudo-spectral time domain (PSTD) algorithm

    DEFF Research Database (Denmark)

    Tong, M.S.; Lu, Y.; Chen, Y.

    2005-01-01

    A planar stratified dielectric slab medium, which is an interesting problem in optics and geophysics, is studied using a pseudo-spectral time-domain (PSTD) algorithm. Time domain electric fields and frequency domain propagation characteristics of both single and periodic dielectric slab...

  14. Seasonal cyclogenesis and the role of near-surface stratified layer in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Murty, V.S.N.; Sarma, M.S.S.; Tilvi, V.

    The role of the near-surface stratified layer developed due to the spread of low salinity waters under the influence of freshwater influx on the cyclogenesis over the Bay of Bengal is addressed. The seasonal variation of the Effective Oceanic Layer...

  15. Analysing stratified medicine business models and value systems: innovation-regulation interactions.

    Science.gov (United States)

    Mittra, James; Tait, Joyce

    2012-09-15

    Stratified medicine offers both opportunities and challenges to the conventional business models that drive pharmaceutical R&D. Given the increasingly unsustainable blockbuster model of drug development, due in part to maturing product pipelines, alongside increasing demands from regulators, healthcare providers and patients for higher standards of safety, efficacy and cost-effectiveness of new therapies, stratified medicine promises a range of benefits to pharmaceutical and diagnostic firms as well as healthcare providers and patients. However, the transition from 'blockbusters' to what might now be termed 'niche-busters' will require the adoption of new, innovative business models, the identification of different and perhaps novel types of value along the R&D pathway, and a smarter approach to regulation to facilitate innovation in this area. In this paper we apply the Innogen Centre's interdisciplinary ALSIS methodology, which we have developed for the analysis of life science innovation systems in contexts where the value creation process is lengthy, expensive and highly uncertain, to this emerging field of stratified medicine. In doing so, we consider the complex collaboration, timing, coordination and regulatory interactions that shape business models, value chains and value systems relevant to stratified medicine. More specifically, we explore in some depth two convergence models for co-development of a therapy and diagnostic before market authorisation, highlighting the regulatory requirements and policy initiatives within the broader value system environment that have a key role in determining the probable success and sustainability of these models. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Modified Limiting Equilibrium Method for Stability Analysis of Stratified Rock Slopes

    Directory of Open Access Journals (Sweden)

    Rui Yong

    2016-01-01

    Full Text Available The stratified rock of Jurassic strata is widely distributed in Three Gorges Reservoir Region. The limit equilibrium method is generally utilized in the stability analysis of rock slope with single failure plane. However, the stratified rock slope cannot be accurately estimated by this method because of different bedding planes and their variable shear strength parameters. Based on the idealized model of rock slope with bedding planes, a modified limiting equilibrium method is presented to determine the potential sliding surface and the factor of safety for the stratified rock slope. In this method, the S-curve model is established to define the spatial variations of the shear strength parameters c and  φ of bedding plane and the tensile strength of rock mass. This method was applied in the stability evaluation of typical stratified rock slope in Three Gorges Reservoir Region, China. The result shows that the factor of safety of the case study is 0.973, the critical sliding surface for the potential slip surface appears at bedding plane C, and the tension-controlled failure occurs at 10.5 m to the slope face.

  17. Personalized medicine for prevention: can risk stratified screening decrease colorectal cancer mortality at an acceptable cost?

    Science.gov (United States)

    Subramanian, Sujha; Bobashev, Georgiy; Morris, Robert J; Hoover, Sonja

    2017-04-01

    Tailored health care interventions are expected to transform clinical practice. The objective of this study was to develop an innovative model to assess the effectiveness, cost, and harms of risk stratified colorectal cancer screening. We updated a previously validated microsimulation model consisting of three interlinked components: risk assessment, natural history, and screening/treatment modules. We used data from representative national surveys and the literature to create a synthetic population that mimics the family history and genetic profile of the US population. We applied risk stratification based on published risk assessment tools to triage individuals into five risk categories: high, increased, medium, decreased, and low. On average, the incremental cost of risk stratified screening for colorectal cancer compared to the current approach at 60% and 80% compliance rates is $18,342 and $23,961 per life year gained. The harms in terms of false positives and perforations are consistently lower for personalized scenarios across all compliance rates. False positives are reduced by more than 47.0% and perforations by at least 9.9%. There is considerable uncertainty in the life years gained, but the reduction in harms remains stable under all scenarios. A key finding is that risk stratified screening can reduce harms at all levels of compliance. Therefore, selection of screening scenarios should include comprehensive comparisons of mortality, harms from screening, and cost. This study provides guidance for evaluating risk stratified cancer screening and further research is required to identify optimal implementation approaches in the real-world setting.

  18. Theoretical and experimental investigation into the explosive boiling potential of thermally stratified liquid-liquid systems

    NARCIS (Netherlands)

    Fabiano, B.; Kersten, R.J.A.; Opschoor, G.; Pastorino, R.

    2002-01-01

    The occurrence of a rapid phase transition, or so-called explosive boiling, when a cold volatile liquid comes into contact with a hot liquid or hot surface is a potential hazard in industry. This study was focused on the explosive boiling potential of thermally stratified liquid-liquid systems that

  19. Experiments on one-phase thermally stratified flows in nuclear reactor pipe lines

    International Nuclear Information System (INIS)

    Rezende, Hugo Cesar; Navarro, Moyses Alberto; Jordao, Elizabete; Santos, Andre Augusto Campagnole dos

    2009-01-01

    The phenomenon of thermal stratified flows occurs when two different layers of the same liquid at different temperatures flow separately in horizontal pipes without appreciable mixing. This phenomenon was not considered in the design stage of most of the operating nuclear power plants, but in last two decades it has become apparent due to the temperature monitoring of piping systems. The occurrence of temperature differences of about 200 deg C have been found in a narrow band around the hot and cold water interface in components under stratified flows. Loadings due to thermal stratification affected the integrity of safety related piping systems. This paper presents the results of a range of experiments performed to simulate one phase thermally stratified flows in geometry and flow condition representing a nuclear reactor steam generator injection nozzle. They have the objective of studying the flow configurations and understanding the evolution of the thermal stratification process. The driving parameter considered to characterize flow under stratified regime due to difference in specific masses is the Froude number. Different Froude numbers, from 0.018 to 0.22, were obtained in different testes by setting injection cold water flow rates and hot water initial temperatures as planned in the test matrix. Results are presented showing the influence of Froude number on the hot and cold water interface position, temperature gradients and striping phenomenon. (author)

  20. Study of stratified dielectric slab medium structures using pseudo-spectral time domain (PSTD) algorithm

    DEFF Research Database (Denmark)

    Tong, M.S.; Lu, Y.; Chen, Y.

    2005-01-01

    A planar stratified dielectric slab medium, which is an interesting problem in optics and geophysics, is studied using a pseudo-spectral time-domain (PSTD) algorithm. Time domain electric fields and frequency domain propagation characteristics of both single and periodic dielectric slab-layer str...

  1. Study on Reform of College English Stratified Teaching Based on School-Based Characteristics

    Science.gov (United States)

    Yang, Liu

    2012-01-01

    Considering the status quo of college English teaching, we implement stratified teaching, which reflects the idea of stratification in terms of teaching objects, teaching management, teaching process and assessment and evaluation, makes each students get development to the greatest extent in interactive teaching practice of teaching and learning…

  2. In vitro Demonstration of Cancer Inhibiting Properties from Stratified Self-Organized Plasma-Liquid Interface.

    Science.gov (United States)

    Chen, Zhitong; Zhang, Shiqiang; Levchenko, Igor; Beilis, Isak I; Keidar, Michael

    2017-09-22

    Experiments on plasma-liquid interaction and formation of thinly stratified self-organized patterns at plasma-liquid interface have revealed a nontrivial cancer-inhibiting capability of liquid media treated at self-organized interfacial patterns. A pronounced cancer suppressing activity towards at least two cancer cells, breast cancer MDA-MB-231 and human glioblastoma U87 cancer lines, was demonstrated in vitro. After a short treatment at the thinly stratified self-organized plasma-liquid interface pattern, the cancer inhibiting media demonstrate pronounced suppressing and apoptotic activities towards tumor cells. Importantly, this would have been impossible without interfacial stratification of plasma jet to thin (of several µm) current filaments, which plays a pivotal role in building up the cancer inhibition properties. Furthermore, thinly stratified, self-organized interfacial discharge is capable to efficiently control the ROS and RNS concentrations in the cancer-inhibiting media. In particular, abnormal ROS/RNS ratios are not achievable in discharges since they do not form stratified thin-filament patterns. Our findings could be tremendously important for understanding the cancer proliferation problem and hence, the potential of this approach in tackling the challenges of high cancer-induced mortality should be explored.

  3. Complexity in fluids

    International Nuclear Information System (INIS)

    Bayly, B.

    1991-01-01

    Fluids are basically very simple things. The fluids encountered all the time - air, water, milk, coffee, etc. - are undramatic. One blob of a given fluid looks much like any other, except for such gross properties as volume or mass. Of course, blobs of fluid come in different shapes. However, it's easy to change the shape of a blob of fluid, with the result that we rarely think of the shape of a fluid blob as a defining property. In fact, a blob that starts with one shape can be deformed into almost any other shape, with arbitrarily small input of energy. When one talks about lumps of a solid, in contrast, shape is important. This is because it takes work, i.e., energy, to change the shape of a solid. Making a small deformation from some rest configuration takes a small amount of energy, and a large deformation takes a lot of energy. Sometimes, as in idealized elastic systems, the required energy goes to infinity as the deformation becomes unbounded. Real solids usually break if you deform them enough; all subsequent deformations cost no energy. Basically, a finite deformation requires finite energy. Complexity arises in fluid systems because the shape of a blob of fluid is indeterminate. Nothing prevents an initially simple fluid blob from deforming into the weirdest shape imaginable. It is the absence of any kind of blob-shape constraint that allows complexity to enter fluid science. During these lectures the author briefly describes a few areas in which complexity arises and has to be dealt with. These lectures will be roughly divided as follows: (1) physical and mathematical description of fluids and flows; (2) flow transport and ergodic theory; (3) magnetic dynamos and related problems; (4) flow instabilities; (5) turbulence

  4. Fluid loading responsiveness

    NARCIS (Netherlands)

    Geerts, Bart

    2011-01-01

    Patients in the intensive care unit (ICU) and in the peri-operative phase are dependent on physicians and nurses for their fluid intake. Volume status optimization is required to maximize oxygen delivery to vital organs. Unnecessary fluid administration can, however, lead to general and pulmonary

  5. Fluid Statics and Archimedes

    Indian Academy of Sciences (India)

    stationary fluid only normal stress (pressure) is present and tangential stresses are absent. In this article we ... delayed the discovery of the principle by a few centuries! Archimedes formulated his laws on buoyancy ... stress in the study of mechanics of solids and fluids (see Boxl). Just as temperature and density, stress can ...

  6. Applications of fluid dynamics

    International Nuclear Information System (INIS)

    Round, G.R.; Garg, V.K.

    1986-01-01

    This book describes flexible and practical approach to learning the basics of fluid dynamics. Each chapter is a self-contained work session and includes a fluid dynamics concept, an explanation of the principles involved, an illustration of their application and references on where more detailed discussions can be found

  7. Tumor interstitial fluid

    DEFF Research Database (Denmark)

    Gromov, Pavel; Gromova, Irina; Olsen, Charlotta J.

    2013-01-01

    Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment through various mechanisms, which include classical secr...

  8. Peritoneal fluid culture

    Science.gov (United States)

    Culture - peritoneal fluid ... sent to the laboratory for Gram stain and culture. The sample is checked to see if bacteria ... The peritoneal fluid culture may be negative, even if you have ... diagnosis of peritonitis is based on other factors, in addition ...

  9. Time Independent Fluids

    Science.gov (United States)

    Collyer, A. A.

    1973-01-01

    Discusses theories underlying Newtonian and non-Newtonian fluids by explaining flow curves exhibited by plastic, shear-thining, and shear-thickening fluids and Bingham plastic materials. Indicates that the exact mechanism governing shear-thickening behaviors is a problem of further study. (CC)

  10. Relativistic thermodynamics of fluids

    International Nuclear Information System (INIS)

    Souriau, J.-M.

    1977-05-01

    The relativistic covariant definition of a statistical equilibrium, applied to a perfect gas, involves a 'temperature four-vector', whose direction is the mean velocity of the fluid, and whose length is the reciprocal temperature. The hypothesis of this 'temperature four-vector' being a relevant variable for the description of the dissipative motions of a simple fluid is discussed. The kinematics is defined by using a vector field and measuring the number of molecules. Such a dissipative fluid is subject to motions involving null entropy generation; the 'temperature four-vector' is then a Killing vector; the equations of motion can be completely integrated. Perfect fluids can be studied by this way and the classical results of Lichnerowicz are obtained. In weakly dissipative motions two viscosity coefficient appear together with the heat conductibility coefficient. Two other coefficients perharps measurable on real fluids. Phase transitions and shock waves are described with using the model [fr

  11. Slip in quantum fluids

    International Nuclear Information System (INIS)

    Einzel, D.; Parpia, J.M.

    1997-01-01

    In this review the authors describe theoretical and experimental investigations of general slip phenomena in context with the flow of the quantum liquids 3 He, 4 He and their mixtures at low temperatures. The phenomena of slip is related to a boundary effect. It occurs when sufficiently dilute gases flow along the wall of an experimental cell. A fluid is said to exhibit slip when the fluid velocity at the wall is not equal to the wall's velocity. Such a situation occurs whenever the wall reflects the fluid particles in a specular-like manner, and/or if the fluid is describable in terms of a dilute ordinary gas (classical fluid) or a dilute gas of thermal excitations (quantum fluid). The slip effect in quantum fluids is discussed theoretically on the basis of generalized Landau-Boltzmann transport equations and generalized to apply to a regime of ballistic motion of the quasiparticles in the fluid. The central result is that the transport coefficient of bulk shear viscosity, which typically enters in the Poiseuille flow resistance and the transverse acoustic impedance, has to be replaced by geometry dependent effective viscosity, which depends on the details of the interaction of the fluid particles with the cell walls. The theoretical results are compared with various experimental data obtained in different geometries and for both Bose and Fermi quantum fluids. Good agreement between experiment and theory is found particularly in the case of pure normal and superfluid 3 He, with discrepancies probably arising because of deficiencies in characterization of the experimental surfaces

  12. General Practitioners' and patients' perceptions towards stratified care: a theory informed investigation.

    Science.gov (United States)

    Saunders, Benjamin; Bartlam, Bernadette; Foster, Nadine E; Hill, Jonathan C; Cooper, Vince; Protheroe, Joanne

    2016-08-31

    Stratified primary care involves changing General Practitioners' (GPs) clinical behaviour in treating patients, away from the current stepped care approach to instead identifying early treatment options that are matched to patients' risk of persistent disabling pain. This article explores the perspectives of UK-based GPs and patients about a prognostic stratified care model being developed for patients with the five most common primary care musculoskeletal pain presentations. The focus was on views about acceptability, and anticipated barriers and facilitators to the use of stratified care in routine practice. Four focus groups and six semi-structured telephone interviews were conducted with GPs (n = 23), and three focus groups with patients (n = 20). Data were analysed thematically; and identified themes examined in relation to the Theoretical Domains Framework (TDF), which facilitates comprehensive identification of behaviour change determinants. A critical approach was taken in using the TDF, examining the nuanced interrelationships between theoretical domains. Four key themes were identified: Acceptability of clinical decision-making guided by stratified care; impact on the therapeutic relationship; embedding a prognostic approach within a biomedical model; and practical issues in using stratified care. Whilst within each theme specific findings are reported, common across themes was the identified relationships between the theoretical domains of knowledge, skills, professional role and identity, environmental context and resources, and goals. Through analysis of these identified relationships it was found that, for GPs and patients to perceive stratified care as being acceptable, it must be seen to enhance GPs' knowledge and skills, not undermine GPs' and patients' respective identities and be integrated within the environmental context of the consultation with minimal disruption. Findings highlight the importance of taking into account the context of

  13. Absorption fluids data survey

    Science.gov (United States)

    Macriss, R. A.; Zawacki, T. S.

    Development of improved data for the thermodynamic, transport and physical properties of absorption fluids were studied. A specific objective of this phase of the study is to compile, catalog and coarse screen the available US data of known absorption fluid systems and publish it as a first edition document to be distributed to manufacturers, researchers and others active in absorption heat pump activities. The methodology and findings of the compilation, cataloguing and coarse screening of the available US data on absorption fluid properties and presents current status and future work on this project are summarized. Both in house file and literature searches were undertaken to obtain available US publications with pertinent physical, thermodynamic and transport properties data for absorption fluids. Cross checks of literature searches were also made, using available published bibliographies and literature review articles, to eliminate secondary sources for the data and include only original sources and manuscripts. The properties of these fluids relate to the liquid and/or vapor state, as encountered in normal operation of absorption equipment employing such fluids, and to the crystallization boundary of the liquid phase, where applicable. The actual data were systematically classified according to the type of fluid and property, as well as temperature, pressure and concentration ranges over which data were available. Data were sought for 14 different properties: Vapor-Liquid Equilibria, Crystallization Temperature, Corrosion Characteristics, Heat of Mixing, Liquid-Phase-Densities, Vapor-Liquid-Phase Enthalpies, Specific Heat, Stability, Viscosity, Mass Transfer Rate, Heat Transfer Rate, Thermal Conductivity, Flammability, and Toxicity.

  14. FRACTURING FLUID CHARACTERIZATION FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Subhash Shah

    2000-08-01

    Hydraulic fracturing technology has been successfully applied for well stimulation of low and high permeability reservoirs for numerous years. Treatment optimization and improved economics have always been the key to the success and it is more so when the reservoirs under consideration are marginal. Fluids are widely used for the stimulation of wells. The Fracturing Fluid Characterization Facility (FFCF) has been established to provide the accurate prediction of the behavior of complex fracturing fluids under downhole conditions. The primary focus of the facility is to provide valuable insight into the various mechanisms that govern the flow of fracturing fluids and slurries through hydraulically created fractures. During the time between September 30, 1992, and March 31, 2000, the research efforts were devoted to the areas of fluid rheology, proppant transport, proppant flowback, dynamic fluid loss, perforation pressure losses, and frictional pressure losses. In this regard, a unique above-the-ground fracture simulator was designed and constructed at the FFCF, labeled ''The High Pressure Simulator'' (HPS). The FFCF is now available to industry for characterizing and understanding the behavior of complex fluid systems. To better reflect and encompass the broad spectrum of the petroleum industry, the FFCF now operates under a new name of ''The Well Construction Technology Center'' (WCTC). This report documents the summary of the activities performed during 1992-2000 at the FFCF.

  15. Materials for ER Fluids

    Science.gov (United States)

    Bloodworth, Robert; Wendt, Eckhard

    Recent improvements in the physical understanding of ER fluids have led to the rational design of new ER materials with improved properties. This paper gives an overview of several recent developments in the formulation of ER fluids, concentrating on new particulate phases for ER dispersions. Examples of homogeneous ER fluids are also discussed. The trend leading to designed ER dispersions is demonstrated by a new class of electrorheological fluids based on non-aqueous polyurethane dispersions. The fluids exhibit an attractive combination of properties: low viscosity, high ER effect, and low conductivity. The dispersed phase consists of a specially developed polyurethane elastomer which solvates and stabilizes metal salts. The polymer network density influences the mobility of the dissolved ions, allowing a surprising degree of control over the ER effect. Properties such as the field strength dependence of the ER-effect, switching response, and conductivity of these fluids correlate directly with changes in the polymer structure. Electrorheological measurements in a couette viscometer (shear-mode) and in a model shock absorber (flow-mode) using a commercial polyurethane-based fluid show that the ER effect is also dependent upon the shearing geometry.

  16. Application of Lie group analysis in geophysical fluid dynamics

    CERN Document Server

    Ibragimov, Ranis

    2011-01-01

    This is the first monograph dealing with the applications of the Lie group analysis to the modeling equations governing internal wave propagation in the deep ocean. A new approach to describe the nonlinear interactions of internal waves in the ocean is presented. While the central idea of the book is to investigate oceanic internal waves through the prism of Lie group analysis, it is also shown for the first time that internal wave beams, representing exact solutions to the equation of motion of stratified fluid, can be found by solving the given model as invariant solutions of nonlinear equat

  17. Fluid Dynamics And Mass Transfer In Two-Fluid Taylor-Couette Flow

    International Nuclear Information System (INIS)

    Baier, G.; Graham, M.D.

    1998-01-01

    The Taylor-Couette instability of a single liquid phase can be used to enhance mass transfer processes such as filtration and membrane separations. We consider here the possibility of using this instability to enhance interphase transport in a two-fluid systems, with a view toward improved liquid-liquid extractions for biotechnology applications. We investigate the centrifugal instability of a pair of radially stratified immiscible liquids in the annular gap between concentric, corotating cylinders: two-fluid Taylor-Couette flow. Experiments show that a two-layer flow with a well-defined interface and Taylor vortices in each phase can be obtained. The experimental results are in good agreement with predictions of inviscid arguments based on a two-phase extension of Rayleigh's criterion, as well as with detailed linear stability calculations. For a given geometry, the most stable configuration occurs for fluids of roughly (exactly in the inviscid limit) equal dynamic viscosities. A number of preliminary mass transfer experiments have also been performed, in the presence of axial counterflow. The onset of Taylor vortices coincides with a clear decrease in the extent of axial dispersion and an increase in the rate of interphase transport, thus suggesting that this flow geometry may provide an effective means for countercurrent chromatographic separations

  18. Cerebral spinal fluid (CSF) collection

    Science.gov (United States)

    ... ency/article/003428.htm Cerebral spinal fluid (CSF) collection To use the sharing features on this page, please enable JavaScript. Cerebrospinal fluid (CSF) collection is a test to look at the fluid ...

  19. Fluid movement and creativity.

    Science.gov (United States)

    Slepian, Michael L; Ambady, Nalini

    2012-11-01

    Cognitive scientists describe creativity as fluid thought. Drawing from findings on gesture and embodied cognition, we hypothesized that the physical experience of fluidity, relative to nonfluidity, would lead to more fluid, creative thought. Across 3 experiments, fluid arm movement led to enhanced creativity in 3 domains: creative generation, cognitive flexibility, and remote associations. Alternative mechanisms such as enhanced mood and motivation were also examined. These results suggest that creativity can be influenced by certain types of physical movement. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  20. Fundamentals of fluid lubrication

    Science.gov (United States)

    Hamrock, Bernard J.

    1991-01-01

    The aim is to coordinate the topics of design, engineering dynamics, and fluid dynamics in order to aid researchers in the area of fluid film lubrication. The lubrication principles that are covered can serve as a basis for the engineering design of machine elements. The fundamentals of fluid film lubrication are presented clearly so that students that use the book will have confidence in their ability to apply these principles to a wide range of lubrication situations. Some guidance on applying these fundamentals to the solution of engineering problems is also provided.

  1. Synthetic Base Fluids

    Science.gov (United States)

    Brown, M.; Fotheringham, J. D.; Hoyes, T. J.; Mortier, R. M.; Orszulik, S. T.; Randles, S. J.; Stroud, P. M.

    The chemical nature and technology of the main synthetic lubricant base fluids is described, covering polyalphaolefins, alkylated aromatics, gas-to-liquid (GTL) base fluids, polybutenes, aliphatic diesters, polyolesters, polyalkylene glycols or PAGs and phosphate esters.Other synthetic lubricant base oils such as the silicones, borate esters, perfluoroethers and polyphenylene ethers are considered to have restricted applications due to either high cost or performance limitations and are not considered here.Each of the main synthetic base fluids is described for their chemical and physical properties, manufacture and production, their chemistry, key properties, applications and their implications when used in the environment.

  2. The implications of gas slug ascent in a stratified magma for acoustic and ground deformation source mechanisms in Strombolian eruptions

    Science.gov (United States)

    Capponi, Antonio; Lane, Stephen J.; James, Mike R.

    2017-06-01

    The interpretation of geophysical measurements at active volcanoes is vital for hazard assessment and for understanding fundamental processes such as magma degassing. For Strombolian activity, interpretations are currently underpinned by first-order fluid dynamic models which give relatively straightforward relationships between geophysical signals and gas and magma flow. However, recent petrological and high-speed video evidence has indicated the importance of rheological stratification within the conduit and, here, we show that under these conditions, the straightforward relationships break down. Using laboratory analogue experiments to represent a rheologically-stratified conduit we characterise the distinct variations in the shear stress exerted on the upper sections of the flow tube and in the gas pressures measured above the liquid surface, during different degassing flow configurations. These signals, generated by varying styles of gas ascent, expansion and burst, can reflect field infrasonic measurements and ground motion proximal to a vent. The shear stress signals exhibit timescales and trends in qualitative agreement with the near-vent inflation-deflation cycles identified at Stromboli. Therefore, shear stress along the uppermost conduit may represent a plausible source of near-vent tilt, and conduit shear contributions should be considered in the interpretation of ground deformation, which is usually attributed to pressure sources only. The same range of flow processes can produce different experimental infrasonic waveforms, even for similar masses of gas escape. The experimental data resembled infrasonic waveforms acquired from different vents at Stromboli associated with different eruptive styles. Accurate interpretation of near-vent ground deformation, infrasonic signal and eruptive style therefore requires detailed understanding of: a) spatiotemporal magma rheology in the shallow conduit, and b) shallow conduit geometry, as well as bubble

  3. Gas slug ascent in a stratified magma: Implications of flow organisation and instability for Strombolian eruption dynamics

    Science.gov (United States)

    Capponi, A.; James, M. R.; Lane, S. J.

    2016-02-01

    The canonical Strombolian paradigm of a gas slug ascending and bursting in a homogeneous low-viscosity magma cannot explain the complex details in eruptive dynamics recently revealed by field measurements and textural and geochemical analyses. Evidence points to the existence of high-viscosity magma at the top of the conduit of Strombolian-type volcanoes, acting as a plug. Here, new experiments detail the range of flow configurations that develop during the ascent and burst of a slug through rheologically stratified magma within a conduit. End-member scenarios of a tube fully filled with either high- or low-viscosity liquid bracket three main flow configurations: (1) a plug sufficiently large to fully accommodate an ascending gas slug; (2) A plug that can accommodate the intrusion of low-viscosity liquid driven by the gas expansion, but not all the slug volume, so the slug bursts with the nose in the plug whilst the base is still in the low-viscosity liquid; (3) Gas expansion is sufficient to drive the intrusion of low-viscosity liquid through the plug, with the slug bursting in the low-viscosity layer emplaced dynamically above the plug. We show that the same flow configurations are viable at volcanic-scale through a new experimentally-validated 1D model and 3D computational fluid dynamic simulations. Applied to Stromboli, our results demonstrate that the key parameters controlling the transition between each configuration are gas volume, plug thickness and plug viscosity. The flow processes identified include effective dynamic narrowing and widening of the conduit, instabilities within the falling magma film, transient partial and complete blockage of the conduit, and slug disruption. These complexities influence eruption dynamics and vigour, promoting magma mingling and resulting in pulsatory release of gas.

  4. The New Rich and Their Unplanned Births: Stratified Reproduction under China's Birth-planning Policy.

    Science.gov (United States)

    Shi, Lihong

    2017-12-01

    This article explores the creation and ramifications of a stratified reproductive system under China's state control of reproduction. Within this system, an emerging group of "new rich" are able to circumvent birth regulations and have unplanned births because of their financial capabilities and social networks. While China's birth-planning policy is meant to be enforced equally for all couples, the unequal access to wealth and bureaucratic power as a result of China's widening social polarization has created disparate reproductive rights and experiences. This article identifies three ways in which reproductive privileges are created. It further explores how a stratified reproductive system under state population control reinforces social polarization. While many socially marginalized couples are unable to register their unplanned children for citizenship status and social benefits, the new rich are able to legitimate their births and transfer their privilege and status to their children, thus reproducing a new generation of elites. © 2016 by the American Anthropological Association.

  5. Effect of turbulence and convection on melting of the ice shelves in stratified environment

    Science.gov (United States)

    Gayen, Bishakdatta; Mondal, Mainak; Griffiths, Ross

    2017-11-01

    We have performed high-resolution simulations to investigate the convective boundary layer when a wall of ice dissolves into stratified seawater under polar ocean conditions. Under the stratified ambient condition, melt water spreads out into the interior in a series of nearly horizontal layers due to double diffusive convection. The layer thickness depends on the ambient density gradient and the difference in density between the freezing point (interface temperature) and the ambient water temperature. For a small O(1) m hight box the layers are laminar and results for layer depth are in agreement with the experimental results. However, for significantly higher ice walls the layer scaling differs as a result of turbulent mixing. Stratification has a significant effect on melt rate which further helps in the shaping of ice-wall. The temperature and density structures found under Pine Island Glacier show several layers having a vertical scale that can also be explained by this study.

  6. Research on stratified evolution of composite materials under four-point bending loading

    Science.gov (United States)

    Hao, M. J.; You, Q. J.; Zheng, J. C.; Yue, Z.; Xie, Z. P.

    2017-12-01

    In order to explore the effect of stratified evolution and delamination on the load capacity and service life of the composite materials under the four-point bending loading, the artificial tectonic defects of the different positions were set up. The four-point bending test was carried out, and the whole process was recorded by acoustic emission, and the damage degree of the composite layer was judged by the impact accumulation of the specimen - time-amplitude history chart, load-time-relative energy history chart, acoustic emission impact signal positioning map. The results show that the stratified defects near the surface of the specimen accelerate the process of material failure and expansion. The location of the delamination defects changes the bending performance of the composites to a great extent. The closer the stratification defects are to the surface of the specimen, the greater the damage, the worse the service capacity of the specimen.

  7. Doubly stratified mixed convection flow of Maxwell nanofluid with heat generation/absorption

    Energy Technology Data Exchange (ETDEWEB)

    Abbasi, F.M., E-mail: abbasisarkar@gmail.com [Department of Mathematics, Comsats Institute of Information Technology, Islamabad 44000 (Pakistan); Shehzad, S.A. [Department of Mathematics, Comsats Institute of Information Technology, Sahiwal 57000 (Pakistan); Hayat, T. [Department of Mathematics, Quaid-i-Azam University, 45320, Islamabad 44000 (Pakistan); NAAM Research Group, Department of Mathematics, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Ahmad, B. [NAAM Research Group, Department of Mathematics, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)

    2016-04-15

    Magnetohydrodynamic (MHD) doubly stratified flow of Maxwell nanofluid in presence of mixed convection is analyzed in this article. Effects of thermophoresis, Brownian motion and heat generation/absorption are present. The flow is induced due to linear stretching of sheet. Mathematical formulation is made under boundary layer approach. Expressions of velocity, temperature and nanoparticles concentration are developed. The obtained results are plotted and discussed to examine the variations in temperature and nanoparticles concentration due to different physical parameters. Numerical computations are made to obtain the values of local Nusselt and Sherwood numbers. Impact of sundry parameters on the flow quantities is analyzed graphically. - Highlights: • Double stratified flow of Maxwell nanofluid with mixed convection is modeled. • Thermophoresis and Brownian motion effects are encountered. • Computations are made to obtain the solution expressions. • Numerical values of local Nusselt and Sherwood numbers are computed and examined.

  8. Quantum image pseudocolor coding based on the density-stratified method

    Science.gov (United States)

    Jiang, Nan; Wu, Wenya; Wang, Luo; Zhao, Na

    2015-05-01

    Pseudocolor processing is a branch of image enhancement. It dyes grayscale images to color images to make the images more beautiful or to highlight some parts on the images. This paper proposes a quantum image pseudocolor coding scheme based on the density-stratified method which defines a colormap and changes the density value from gray to color parallel according to the colormap. Firstly, two data structures: quantum image GQIR and quantum colormap QCR are reviewed or proposed. Then, the quantum density-stratified algorithm is presented. Based on them, the quantum realization in the form of circuits is given. The main advantages of the quantum version for pseudocolor processing over the classical approach are that it needs less memory and can speed up the computation. Two kinds of examples help us to describe the scheme further. Finally, the future work are analyzed.

  9. Sedimentary Fabrics of Stratified Slope Deposits at a Site near Hoover's Camp, Shenandoah National Park, Virginia

    Science.gov (United States)

    Smoot, Joseph P.

    2004-01-01

    An outcrop of stratified slope deposits in Shenandoah National Park is described in detail. The Pleistocene age deposits are comprised of a mixture of clay to cobbles defining a series of offlapping wedges. Elongate clasts are oriented parallel to wedge boundaries except at the toe of the wedge, where they are oriented nearly vertical. The wedges represent sedimentation by freeze-thaw of ground ice. Thin layers of pebbly sand separate matrix-rich wedge deposits, which represent sheetfloods during periods of thaw. Thicker sand layers and lenses of clay are placed upslope of coarse-grained wedge fronts. This association represents ponding of water around the solifluction lobe topography during warm periods. Stratified slope deposits at an outcrop at a higher elevation lack the sandy sheetflood and pond deposits, whereas sheetflood fabrics dominate deposits at a lower elevation. These variations are attributed to differences in temperature at the different elevations.

  10. The Hand Burn Severity (HABS) score: A simple tool for stratifying severity of hand burns.

    Science.gov (United States)

    Bache, Sarah E; Fitzgerald O'Connor, Edmund; Theodorakopoulou, Evgenia; Frew, Quentin; Philp, Bruce; Dziewulski, Peter

    2017-02-01

    Hand burns represent a unique challenge to the burns team due to the intricate structure and unrivalled functional importance of the hand. The initial assessment and prognosis relies on consideration of the specific site involved as well as depth of the burn. We created a simple severity score that could be used by referring non-specialists and researchers alike. The Hand Burn Severity (HABS) score stratifies hand burns according to severity with a numerical value of between 0 (no burn) and 18 (most severe) per hand. Three independent assessors scored the photographs of 121 burned hands of 106 adult and paediatric patients, demonstrating excellent inter-rater reliability (r=0.91, pburn depth alone. The HABS score is a simple to use tool to stratify severity at initial presentation of hand burns which will be useful when referring, and when reporting outcomes. Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

  11. Stratified polymer brushes from microcontact printing of polydopamine initiator on polymer brush surfaces.

    Science.gov (United States)

    Wei, Qiangbing; Yu, Bo; Wang, Xiaolong; Zhou, Feng

    2014-06-01

    Stratified polymer brushes are fabricated using microcontact printing (μCP) of initiator integrated polydopamine (PDOPBr) on polymer brush surfaces and the following surface initiated atom transfer radical polymerization (SI-ATRP). It is found that the surface energy, chemically active groups, and the antifouling ability of the polymer brushes affect transfer efficiency and adhesive stability of the polydopamine film. The stickiness of the PDOPBr pattern on polymer brush surfaces is stable enough to perform continuous μCP and SI-ATRP to prepare stratified polymer brushes with a 3D topography, which have broad applications in cell and protein patterning, biosensors, and hybrid surfaces. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Estimation of Finite Population Mean in Multivariate Stratified Sampling under Cost Function Using Goal Programming

    Directory of Open Access Journals (Sweden)

    Atta Ullah

    2014-01-01

    Full Text Available In practical utilization of stratified random sampling scheme, the investigator meets a problem to select a sample that maximizes the precision of a finite population mean under cost constraint. An allocation of sample size becomes complicated when more than one characteristic is observed from each selected unit in a sample. In many real life situations, a linear cost function of a sample size nh is not a good approximation to actual cost of sample survey when traveling cost between selected units in a stratum is significant. In this paper, sample allocation problem in multivariate stratified random sampling with proposed cost function is formulated in integer nonlinear multiobjective mathematical programming. A solution procedure is proposed using extended lexicographic goal programming approach. A numerical example is presented to illustrate the computational details and to compare the efficiency of proposed compromise allocation.

  13. A better alternative to stratified permuted block design for subject randomization in clinical trials.

    Science.gov (United States)

    Zhao, Wenle

    2014-12-30

    Stratified permuted block randomization has been the dominant covariate-adaptive randomization procedure in clinical trials for several decades. Its high probability of deterministic assignment and low capacity of covariate balancing have been well recognized. The popularity of this sub-optimal method is largely due to its simplicity in implementation and the lack of better alternatives. Proposed in this paper is a two-stage covariate-adaptive randomization procedure that uses the block urn design or the big stick design in stage one to restrict the treatment imbalance within each covariate stratum, and uses the biased-coin minimization method in stage two to control imbalances in the distribution of additional covariates that are not included in the stratification algorithm. Analytical and simulation results show that the new randomization procedure significantly reduces the probability of deterministic assignments, and improve the covariate balancing capacity when compared to the traditional stratified permuted block randomization. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Numerical simulation of stratified shear flow using a higher order Taylor series expansion method

    Energy Technology Data Exchange (ETDEWEB)

    Iwashige, Kengo; Ikeda, Takashi [Hitachi, Ltd. (Japan)

    1995-09-01

    A higher order Taylor series expansion method is applied to two-dimensional numerical simulation of stratified shear flow. In the present study, central difference scheme-like method is adopted for an even expansion order, and upwind difference scheme-like method is adopted for an odd order, and the expansion order is variable. To evaluate the effects of expansion order upon the numerical results, a stratified shear flow test in a rectangular channel (Reynolds number = 1.7x10{sup 4}) is carried out, and the numerical velocity and temperature fields are compared with experimental results measured by laser Doppler velocimetry thermocouples. The results confirm that the higher and odd order methods can simulate mean velocity distributions, root-mean-square velocity fluctuations, Reynolds stress, temperature distributions, and root-mean-square temperature fluctuations.

  15. NONPARAMETRIC MIXED RATIO ESTIMATOR FOR A FINITE POPULATION TOTAL IN STRATIFIED SAMPLING

    Directory of Open Access Journals (Sweden)

    George Otieno Orwa

    2010-08-01

    Full Text Available We propose a nonparametric regression approach to the estimation of a finite population total in model based frameworks in the case of stratified sampling. Similar work has been done, by Nadaraya and Watson (1964, Hansen et al (1983, and Breidt and Opsomer (2000. Our point of departure from these works is at selection of the sampling weights within every stratum, where we treat the individual strata as compact Abelian groups and demonstrate that the resulting proposed estimator is easier to compute. We also make use of mixed ratios but this time not in the contexts of simple random sampling or two stage cluster sampling, but in stratified sampling schemes, where a void still exists.

  16. Scattering by multiple parallel radially stratified infinite cylinders buried in a lossy half space.

    Science.gov (United States)

    Lee, Siu-Chun

    2013-07-01

    The theoretical solution for scattering by an arbitrary configuration of closely spaced parallel infinite cylinders buried in a lossy half space is presented in this paper. The refractive index and permeability of the half space and cylinders are complex in general. Each cylinder is radially stratified with a distinct complex refractive index and permeability. The incident radiation is an arbitrarily polarized plane wave propagating in the plane normal to the axes of the cylinders. Analytic solutions are derived for the electric and magnetic fields and the Poynting vector of backscattered radiation emerging from the half space. Numerical examples are presented to illustrate the application of the scattering solution to calculate backscattering from a lossy half space containing multiple homogeneous and radially stratified cylinders at various depths and different angles of incidence.

  17. 3D elastic inversion of vertical seismic profiles in horizontally stratified media; Inversion elastique 3D de profils sismiques verticaux en milieux stratifies horizontalement

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.L.

    1997-07-21

    This thesis is devoted to the inversion of VSP (vertical seismic profile) seismic data in order to determine the elastic properties of horizontally stratified media. The VSP records are computed using the full wave elastic modelling in isotropic and transversely isotropic media using Hankel transform, a finite difference scheme and an inverse Hankel transform algorithm, and the propagation equations are determined and numerically solved; the importance of considering a 3D wave propagation model instead of a 1 D one is emphasized. The theoretical VSP inverse problem is then considered, with the seismic waveform inversion set as a least-squares problem, consisting in recovering the distribution of physical parameters which minimize the misfit between calculated and observed VSP. The corresponding problem requires the knowledge of the source function

  18. Experiments on the Microenvironment and Breathing of a Person in Isothermal and Stratified Surroundings

    DEFF Research Database (Denmark)

    Nielsen, Peter V.; Jensen, Rasmus Lund; Litewnicki, Michal

    2009-01-01

    This study investigates the characteristics of human exhalation. Experiments are performed on a breathing thermal manikin in a test room. The manikin is heated, and an artificial lung is used to generate varying air flows with specific flow rates and temperatures for breathing. Smoke visualisation...... is used to show the formation, movement and disappearance of the exhalation jets from both nose and mouth. The exhalation of breathing without ventilation in the room, and with stratified surroundings (displacement ventilation) is analysed....

  19. The stratified flows' characteristics: A numerical study of the influence of technological parameters

    Science.gov (United States)

    Bachurina, Maria V.; Trufanova, Nataliia M.; Kazakov, Alexey V.

    2014-05-01

    Made of polymers with certain supplements multilayer insulation and shielding coatings have a great potential nowadays. An extrusion method of insulation is still the most practically feasible one. Since the covering technology is a simultaneous imposition of all necessary layers (two the semiconducting shields on the insulation and on the conductor and the insulation), of current importance analysis of the influence of various factors on stratified flows' characteristics.

  20. Evaluation of the STRATIFY falls prediction tool on a geriatric unit.

    Science.gov (United States)

    Coker, Esther; Oliver, David

    2003-01-01

    Accurate prediction of fall-prone hospitalized older adults may be integral to reducing falls. The STRATIFY, a simple 5-point falls prediction tool, was prospectively validated on a Geriatric Assessment and Rehabilitation Unit as a one-time initial predictor of patients likely to fall. Sensitivity and specificity were lower than in the original British study. Introducing risk assessments validated elsewhere on a patient care unit or on a hospital-wide scale requires caution.

  1. Men's Health Index: A Pragmatic Approach to Stratifying and Optimizing Men's Health

    OpenAIRE

    Tan, Hui Meng; Tan, Wei Phin; Wong, Jun Hoe; Ho, Christopher Chee Kong; Teo, Chin Hai; Ng, Chirk Jenn

    2014-01-01

    Purpose The proposed Men's Health Index (MHI) aims to provide a practical and systematic framework for comprehensively assessing and stratifying older men with the intention of optimising their health and functional status. Materials and Methods A literature search was conducted using PubMed from 1980 to 2012. We specifically looked for instruments which: assess men's health, frailty and fitness; predict life expectancy, mortality and morbidities. The instruments were assessed by the research...

  2. Modelling of stratified gas-liquid two-phase flow in horizontal circular pipes

    International Nuclear Information System (INIS)

    Sampaio, P.A.B. de; Faccini, J.L.H.; Su, J.

    2006-01-01

    This paper reports numerical and experimental investigation of stratified gas-liquid two-phase flow in horizontal circular pipes. The Reynolds average Navier-Stokes equations (RANS) with κ ω model development stratified gas-liquid two-phase flow are solved by using the finite element methods. A smooth interface surface is assumed without considered the effects of the interfacial waves. The continuity of the shear stress across the interface is enforced with the continuity of the velocity being automatically satisfied by the variational formulation. For it is given position and interface and longitudinal pressure gradient, an inner iteration loop runs to solve nonlinear equations the Newton-Raphson scheme is used to solve the transcendental equations by an outer iteration to determinate the interface position in a 5.2 mm ID circular pipe was measured experimentally by the ultrasonic ultra pulse-echo technique. The numeral were also compared with results in 21 mm ID circular pipe report by Masala (2004). The good agreement between the numerical and experimental results indicates that κ ω model can be applied for the numerical simulation of stratified gas-liquid two phase flow. (author)

  3. Terahertz pulse imaging of stratified architectural materials for cultural heritage studies

    Science.gov (United States)

    Jackson, J. Bianca; Labaune, Julien; Mourou, Gérard; Duling, Irl N.; Walker, Gillian; Bowen, John; Menu, Michel

    2011-06-01

    Terahertz pulse imaging (TPI) is a novel noncontact, nondestructive technique for the examination of cultural heritage artifacts. It has the advantage of broadband spectral range, time-of-flight depth resolution, and penetration through optically opaque materials. Fiber-coupled, portable, time-domain terahertz systems have enabled this technique to move out of the laboratory and into the field. Much like the rings of a tree, stratified architectural materials give the chronology of their environmental and aesthetic history. This work concentrates on laboratory models of stratified mosaics and fresco paintings, specimens extracted from a neolithic excavation site in Catalhoyuk, Turkey, and specimens measured at the medieval Eglise de Saint Jean-Baptiste in Vif, France. Preparatory spectroscopic studies of various composite materials, including lime, gypsum and clay plasters are presented to enhance the interpretation of results and with the intent to aid future computer simulations of the TPI of stratified architectural material. The breadth of the sample range is a demonstration of the cultural demand and public interest in the life history of buildings. The results are an illustration of the potential role of TPI in providing both a chronological history of buildings and in the visualization of obscured wall paintings and mosaics.

  4. Population-based, risk-stratified genetic testing for ovarian cancer risk: a focus group study.

    Science.gov (United States)

    Meisel, S F; Side, L; Fraser, L; Gessler, S; Wardle, J; Lanceley, A

    2013-01-01

    A population-based risk stratification programme for ovarian cancer (OC) may improve OC survival by identifying women at increased risk and implementing an appropriate risk management strategy. The present study explored attitudes towards an OC risk stratification programme incorporating predictive genetic testing and risk-stratified screening as part of a larger study investigating OC screening. Focus groups consisting of 56 members of the general public (mean age 45 years; 34% non-white) were conducted using a hypothetical scenario. The group sessions were recorded, transcribed verbatim and analysed using Framework Analysis. There was strong support for the proposed programme. Genetic testing and risk-stratified screening was thought to raise awareness, offer reassurance and offer opportunities for early intervention. Anxiety was only mentioned in relation to receiving a diagnosis of OC and not with screening per se. Perhaps because lay models of cancer already embrace both environmental and genetic factors, a low-risk result was not anticipated to result in a false sense of immunity. Unexpectedly, participants also wanted to receive cancer prevention advice in conjunction with genetic testing; screening alone was not regarded as sufficient. The encouraging results from this small study warrant further large-scale research into risk-stratified OC screening. Copyright © 2013 S. Karger AG, Basel.

  5. Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs.

    Science.gov (United States)

    West, J. B.; Maloney, J. E.; Castle, B. L.

    1972-01-01

    This investigation set out to answer two questions: (1) are the distal alveoli in the terminal lung units less well perfused than the proximal alveoli, i.e., is there stratification of blood flow; and (2) if so, does this enhance gas exchange in the presence of stratified inequality of ventilation. Excised dog lungs were ventilated with saline and perfused with blood. Following single inspirations of xenon 133 in saline and various periods of breath holding, the expired xenon concentration against volume was measured and it confirmed marked stratified inequality of ventilation under these conditions. By measuring the rate of depletion of xenon from alveoli during a period of blood flow, we showed that the alveoli which emptied at the end of expiration had 16% less blood flow than those exhaling earlier. However, by measuring the xenon concentration in pulmonary venous blood, we found that about 10% less tracer was transferred from the alveoli into the blood when the inspired xenon was stratified within the respiratory zone. Thus while stratification of blood flow was confirmed, it was shown to impair rather than enhance the efficiency of gas transfer.

  6. Applications of Fuzzy Clustering Techniques to Stratified by Tropopause MSU Temperature Retrievals

    Science.gov (United States)

    Munteanu, M. J.; Piraino, P.

    1985-01-01

    The fuzzy partitioned clustering method was applied to predict tropopause height only using microwave information with an eye towards using it on real data under cloudy conditions. In the second stage stratified by tropopause regression temperature retrievals included using only the three or four microwave channels for each 40 mb range. The first step in the experiment is the fuzzy partitioned clustering of the microwave brightness temperatures. This method is a combination of standard hard clustering and discriminant analysis. The fuzzy partitioned clustering uses all the generated probabilities of membership of each pattern vector in any of the given clusters. These probabilities are generated by discriminant analysis to locate the correct cluster. The ultimate goal of standard discriminant analysis is to provide the unique (correct) cluster to which the pattern vector belongs. It was only the maximum of all the generated probabilities. The method uses all the probabilities and weight the regressions generated within each cluster. These regression formulas predict the tropopause height from the microwave brightness temperatures. In the second step the microwave regression temperature retrievals are stratified by tropopause height every 40 mb. The control experiment is defined, the data are stratified by land/ocean, summer/winter, and latitude bands.

  7. Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair.

    Science.gov (United States)

    Jiang, Jie; Tang, Amy; Ateshian, Gerard A; Guo, X Edward; Hung, Clark T; Lu, Helen H

    2010-06-01

    Due to the intrinsically poor repair potential of articular cartilage, injuries to this soft tissue do not heal and require clinical intervention. Tissue engineered osteochondral grafts offer a promising alternative for cartilage repair. The functionality and integration potential of these grafts can be further improved by the regeneration of a stable calcified cartilage interface. This study focuses on the design and optimization of a stratified osteochondral graft with biomimetic multi-tissue regions, including a pre-designed and pre-integrated interface region. Specifically, the scaffold based on agarose hydrogel and composite microspheres of polylactide-co-glycolide (PLGA) and 45S5 bioactive glass (BG) was fabricated and optimized for chondrocyte density and microsphere composition. It was observed that the stratified scaffold supported the region-specific co-culture of chondrocytes and osteoblasts which can lead to the production of three distinct yet continuous regions of cartilage, calcified cartilage and bone-like matrices. Moreover, higher cell density enhanced chondrogenesis and improved graft mechanical property over time. The PLGA-BG phase promoted chondrocyte mineralization potential and is required for the formation of a calcified interface and bone regions on the osteochondral graft. These results demonstrate the potential of the stratified scaffold for integrative cartilage repair and future studies will focus on scaffold optimization and in vivo evaluations.

  8. An affordable and accurate conductivity probe for density measurements in stratified flows

    Science.gov (United States)

    Carminati, Marco; Luzzatto-Fegiz, Paolo

    2015-11-01

    In stratified flow experiments, conductivity (combined with temperature) is often used to measure density. The probes typically used can provide very fine spatial scales, but can be fragile, expensive to replace, and sensitive to environmental noise. A complementary instrument, comprising a low-cost conductivity probe, would prove valuable in a wide range of applications where resolving extremely small spatial scales is not needed. We propose using micro-USB cables as the actual conductivity sensors. By removing the metallic shield from a micro-B connector, 5 gold-plated microelectrodes are exposed and available for 4-wire measurements. These have a cell constant ~550m-1, an intrinsic thermal noise of at most 30pA/Hz1/2, as well as sub-millisecond time response, making them highly suitable for many stratified flow measurements. In addition, we present the design of a custom electronic board (Arduino-based and Matlab-controlled) for simultaneous acquisition from 4 sensors, with resolution (in conductivity, and resulting density) exceeding the performance of typical existing probes. We illustrate the use of our conductivity-measuring system through stratified flow experiments, and describe plans to release simple instructions to construct our complete system for around 200.

  9. Pericardial fluid culture

    Science.gov (United States)

    ... to identify organisms that cause infection. Pericardial fluid gram stain is a related topic. How the Test is ... member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www. ...

  10. Polymer Fluid Dynamics.

    Science.gov (United States)

    Bird, R. Byron

    1980-01-01

    Problems in polymer fluid dynamics are described, including development of constitutive equations, rheometry, kinetic theory, flow visualization, heat transfer studies, flows with phase change, two-phase flow, polymer unit operations, and drag reduction. (JN)

  11. Modeling Fluid Structure Interaction

    National Research Council Canada - National Science Library

    Benaroya, Haym

    2000-01-01

    The principal goal of this program is on integrating experiments with analytical modeling to develop physics-based reduced-order analytical models of nonlinear fluid-structure interactions in articulated naval platforms...

  12. Windshield washer fluid

    Science.gov (United States)

    ... fluid is a brightly colored liquid made of methanol, a poisonous alcohol. Sometimes, small amounts of other toxic alcohols, such as ethylene glycol, are added to the mixture. Some young children ...

  13. Amniotic fluid inflammatory cytokines

    DEFF Research Database (Denmark)

    Abdallah, Morsi; Larsen, Nanna; Grove, Jakob

    2013-01-01

    The aim of the study was to analyze cytokine profiles in amniotic fluid (AF) samples of children developing autism spectrum disorders (ASD) and controls, adjusting for maternal autoimmune disorders and maternal infections during pregnancy.......The aim of the study was to analyze cytokine profiles in amniotic fluid (AF) samples of children developing autism spectrum disorders (ASD) and controls, adjusting for maternal autoimmune disorders and maternal infections during pregnancy....

  14. [Diagnosis: synovial fluid analysis].

    Science.gov (United States)

    Gallo Vallejo, Francisco Javier; Giner Ruiz, Vicente

    2014-01-01

    Synovial fluid analysis in rheumatological diseases allows a more accurate diagnosis in some entities, mainly infectious and microcrystalline arthritis. Examination of synovial fluid in patients with osteoarthritis is useful if a differential diagnosis will be performed with other processes and to distinguish between inflammatory and non-inflammatory forms. Joint aspiration is a diagnostic and sometimes therapeutic procedure that is available to primary care physicians. Copyright © 2014 Elsevier España, S.L. All rights reserved.

  15. Fullerol ionic fluids

    KAUST Repository

    Fernandes, Nikhil

    2010-01-01

    We report for the first time an ionic fluid based on hydroxylated fullerenes (fullerols). The ionic fluid was synthesized by neutralizing the fully protonated fullerol with an amine terminated polyethylene/polypropylene oxide oligomer (Jeffamine®). The ionic fluid was compared to a control synthesized by mixing the partially protonated form (sodium form) of the fullerols with the same oligomeric amine in the same ratio as in the ionic fluids (20 wt% fullerol). In the fullerol fluid the ionic bonding significantly perturbs the thermal transitions and melting/crystallization behavior of the amine. In contrast, both the normalized heat of fusion and crystallization of the amine in the control are similar to those of the neat amine consistent with a physical mixture of the fullerols/amine with minimal interactions. In addition to differences in thermal behavior, the fullerol ionic fluid exhibits a complex viscoelastic behavior intermediate between the neat Jeffamine® (liquid-like) and the control (solid-like). © 2010 The Royal Society of Chemistry.

  16. Thermostating highly confined fluids.

    Science.gov (United States)

    Bernardi, Stefano; Todd, B D; Searles, Debra J

    2010-06-28

    In this work we show how different use of thermostating devices and modeling of walls influence the mechanical and dynamical properties of confined nanofluids. We consider a two dimensional fluid undergoing Couette flow using nonequilibrium molecular dynamics simulations. Because the system is highly inhomogeneous, the density shows strong fluctuations across the channel. We compare the dynamics produced by applying a thermostating device directly to the fluid with that obtained when the wall is thermostated, considering also the effects of using rigid walls. This comparison involves an analysis of the chaoticity of the fluid and evaluation of mechanical properties across the channel. We look at two thermostating devices with either rigid or vibrating atomic walls and compare them with a system only thermostated by conduction through vibrating atomic walls. Sensitive changes are observed in the xy component of the pressure tensor, streaming velocity, and density across the pore and the Lyapunov localization of the fluid. We also find that the fluid slip can be significantly reduced by rigid walls. Our results suggest caution in interpreting the results of systems in which fluid atoms are thermostated and/or wall atoms are constrained to be rigid, such as, for example, water inside carbon nanotubes.

  17. Using Computational Approaches to Improve Risk-Stratified Patient Management: Rationale and Methods.

    Science.gov (United States)

    Luo, Gang; Stone, Bryan L; Sakaguchi, Farrant; Sheng, Xiaoming; Murtaugh, Maureen A

    2015-10-26

    Chronic diseases affect 52% of Americans and consume 86% of health care costs. A small portion of patients consume most health care resources and costs. More intensive patient management strategies, such as case management, are usually more effective at improving health outcomes, but are also more expensive. To use limited resources efficiently, risk stratification is commonly used in managing patients with chronic diseases, such as asthma, chronic obstructive pulmonary disease, diabetes, and heart disease. Patients are stratified based on predicted risk with patients at higher risk given more intensive care. The current risk-stratified patient management approach has 3 limitations resulting in many patients not receiving the most appropriate care, unnecessarily increased costs, and suboptimal health outcomes. First, using predictive models for health outcomes and costs is currently the best method for forecasting individual patient's risk. Yet, accuracy of predictive models remains poor causing many patients to be misstratified. If an existing model were used to identify candidate patients for case management, enrollment would miss more than half of those who would benefit most, but include others unlikely to benefit, wasting limited resources. Existing models have been developed under the assumption that patient characteristics primarily influence outcomes and costs, leaving physician characteristics out of the models. In reality, both characteristics have an impact. Second, existing models usually give neither an explanation why a particular patient is predicted to be at high risk nor suggestions on interventions tailored to the patient's specific case. As a result, many high-risk patients miss some suitable interventions. Third, thresholds for risk strata are suboptimal and determined heuristically with no quality guarantee. The purpose of this study is to improve risk-stratified patient management so that more patients will receive the most appropriate care

  18. Using Computational Approaches to Improve Risk-Stratified Patient Management: Rationale and Methods

    Science.gov (United States)

    Stone, Bryan L; Sakaguchi, Farrant; Sheng, Xiaoming; Murtaugh, Maureen A

    2015-01-01

    Background Chronic diseases affect 52% of Americans and consume 86% of health care costs. A small portion of patients consume most health care resources and costs. More intensive patient management strategies, such as case management, are usually more effective at improving health outcomes, but are also more expensive. To use limited resources efficiently, risk stratification is commonly used in managing patients with chronic diseases, such as asthma, chronic obstructive pulmonary disease, diabetes, and heart disease. Patients are stratified based on predicted risk with patients at higher risk given more intensive care. The current risk-stratified patient management approach has 3 limitations resulting in many patients not receiving the most appropriate care, unnecessarily increased costs, and suboptimal health outcomes. First, using predictive models for health outcomes and costs is currently the best method for forecasting individual patient’s risk. Yet, accuracy of predictive models remains poor causing many patients to be misstratified. If an existing model were used to identify candidate patients for case management, enrollment would miss more than half of those who would benefit most, but include others unlikely to benefit, wasting limited resources. Existing models have been developed under the assumption that patient characteristics primarily influence outcomes and costs, leaving physician characteristics out of the models. In reality, both characteristics have an impact. Second, existing models usually give neither an explanation why a particular patient is predicted to be at high risk nor suggestions on interventions tailored to the patient’s specific case. As a result, many high-risk patients miss some suitable interventions. Third, thresholds for risk strata are suboptimal and determined heuristically with no quality guarantee. Objective The purpose of this study is to improve risk-stratified patient management so that more patients will receive the

  19. Formation and dynamics of a chemically stratified layer below the Earth's CMB

    Science.gov (United States)

    Bouffard, M.; Labrosse, S.; Choblet, G.; Aubert, J.; Fournier, A.

    2017-12-01

    Seismological and magnetic observations are compatible with the presence of a stratified layer below the Earth's CMB (Lay and Young, 1990; Tanaka, 2007; Gubbins, 2007; Helffrich and Kaneshima, 2010; Lesur et al., 2015) and the existence of such a layer has also been predicted by several theoretical arguments listed below. The proposed thickness varies from 60 km to several hundreds of kilometers across the literature, but is usually close to 100 km. The layer may be thermally stratified if the CMB heat flow is subadiabatic (Gubbins et al., 1982; Labrosse et al., 1997; Lister and Buffett, 1998; Labrosse, 2015) but the possibility of a stratification of chemical origin has also been evoked. Various mechanisms have been proposed for the formation of a chemically stratified layer and include barodiffusion i.e. diffusion of light elements against the pressure gradient (Fearn and Loper, 1981; Braginsky, 2006; Gubbins and Davies, 2013), chemical plumes and blobs that would be able to reach the CMB where they would accumulate (Loper, 1989; Braginsky, 1994; Moffatt and Loper, 1994; Loper, 2007) or ascending droplets in a Fe-S system kept from mixing by surface tension (Franck, 1982). Layering may also be present if immiscible liquids evolve as the composition changes due to inner core growth (Helffrich and Kaneshima, 2004). To finish, Buffett and Seagle (2010) also studied the possibility that light elements be dissolved from the mantle into the core, forming a lighter layer that could grow by diffusion over long time scales. So far, no numerical simulation of core dynamics has been able to validate any of these potential mechanisms and produce a chemically stratified layer in a self-consistent manner. Using a particle-in-cell method newly implemented in the code PARODY (E. Dormy, J. Aubert) allowing to perform simulations of thermochemical convection in the infinite Lewis number limit (neglecting the compositional diffusivity), I will show that a chemically stratified

  20. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.

    Science.gov (United States)

    Pahrudin Arrozi, Aslina; Shukri, Siti Nur Syazwani; Wan Ngah, Wan Zurinah; Mohd Yusof, Yasmin Anum; Ahmad Damanhuri, Mohd Hanafi; Makpol, Suzana

    2017-11-01

    Neuroblastoma cell lines such as SH-SY5Y are the most frequently utilized models in neurodegenerative research, and their use has advanced the understanding of the pathology of neurodegeneration over the past few decades. In Alzheimer's disease (AD), several pathogenic mutations have been described, all of which cause elevated levels of pathological hallmarks such as amyloid-beta (Aβ). Although the genetics of Alzheimer's disease is well known, familial AD only accounts for a small number of cases in the population, with the rest being sporadic AD, which contains no known mutations. Currently, most of the in vitro models used to study AD pathogenesis only examine the level of Aβ42 as a confirmation of successful model generation and only perform comparisons between wild-type APP and single mutants of the APP gene. Recent findings have shown that the Aβ42/40 ratio in cerebrospinal fluid (CSF) is a better diagnostic indicator for AD patients than is Aβ42 alone and that more extensive Aβ formation, such as accumulation of intraneuronal Aβ, Aβ plaques, soluble oligomeric Aβ (oAβ), and insoluble fibrillar Aβ (fAβ) occurs in TgCRND8 mice expressing a double-mutant form (Swedish and Indiana) of APP, later leading to greater progressive impairment of the brain. In this study, we generated SH-SY5Y cells stably transfected separately with wild-type APP, the Swedish mutation of APP, and the Swedish and Indiana mutations of APP and evaluated the APP expression as well as the Aβ42/40 ratio in those cells. The double-mutant form of APP (Swedish/Indiana) expressed markedly high levels of APP protein and showed a high Aβ2/40 ratio compared to wild-type and single-mutant cells.

  1. Resonant Tidal Excitation of Internal Waves in the Earth's Fluid Core

    Science.gov (United States)

    Tyler, Robert H.; Kuang, Weijia

    2014-01-01

    It has long been speculated that there is a stably stratified layer below the core-mantle boundary, and two recent studies have improved the constraints on the parameters describing this stratification. Here we consider the dynamical implications of this layer using a simplified model. We first show that the stratification in this surface layer has sensitive control over the rate at which tidal energy is transferred to the core. We then show that when the stratification parameters from the recent studies are used in this model, a resonant configuration arrives whereby tidal forces perform elevated rates of work in exciting core flow. Specifically, the internal wave speed derived from the two independent studies (150 and 155 m/s) are in remarkable agreement with the speed (152 m/s) required for excitation of the primary normal mode of oscillation as calculated from full solutions of the Laplace Tidal Equations applied to a reduced-gravity idealized model representing the stratified layer. In evaluating this agreement it is noteworthy that the idealized model assumed may be regarded as the most reduced representation of the stratified dynamics of the layer, in that there are no non-essential dynamical terms in the governing equations assumed. While it is certainly possible that a more realistic treatment may require additional dynamical terms or coupling, it is also clear that this reduced representation includes no freedom for coercing the correlation described. This suggests that one must accept either (1) that tidal forces resonantly excite core flow and this is predicted by a simple model or (2) that either the independent estimates or the dynamical model does not accurately portray the core surface layer and there has simply been an unlikely coincidence between three estimates of a stratification parameter which would otherwise have a broad plausible range.

  2. statistical fluid theory for associating fluids containing alternating ...

    Indian Academy of Sciences (India)

    Abstract. Statistical associating fluid theory of homonuclear dimerized chain fluids and homonuclear monomer-dimer mixture chain fluids are extended to fluids containing al- ternating heteronuclear chain molecules separately. The proposed models account for the appropriate site-site correlation functions at contact.

  3. Two-phase cooling fluids; Les fluides frigoporteurs diphasiques

    Energy Technology Data Exchange (ETDEWEB)

    Lallemand, A. [Institut National des Sciences Appliquees (INSA), 69 - Lyon (France)

    1997-12-31

    In the framework of the diminution of heat transfer fluid consumption, the concept of indirect refrigerating circuits, using cooling intermediate fluids, is reviewed and the fluids that are currently used in these systems are described. Two-phase cooling fluids advantages over single-phase fluids are presented with their thermophysical characteristics: solid fraction, two-phase mixture enthalpy, thermal and rheological properties, determination of heat and mass transfer characteristics, and cold storage through ice slurry

  4. Viscous Flow with Large Fluid-Fluid Interface Displacement

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Hassager, Ole; Saasen, Arild

    1998-01-01

    The arbitrary Lagrange-Euler (ALE) kinematic description has been implemented in a 3D transient finite element program to simulate multiple fluid flows with fluid-fluid interface or surface displacements. The description of fluid interfaces includes variable interfacial tension, and the formulation...... is useful in the simulation of low and intermediate Reynolds number viscous flow. The displacement of two immiscible Newtonian fluids in a vertical (concentric and eccentric) annulus and a (vertical and inclined)tube is simulated....

  5. Theory of inertial waves in rotating fluids

    Science.gov (United States)

    Gelash, Andrey; L'vov, Victor; Zakharov, Vladimir

    2017-04-01

    The inertial waves emerge in the geophysical and astrophysical flows as a result of Earth rotation [1]. The linear theory of inertial waves is known well [2] while the influence of nonlinear effects of wave interactions are subject of many recent theoretical and experimental studies. The three-wave interactions which are allowed by inertial waves dispersion law (frequency is proportional to cosine of the angle between wave direction and axes of rotation) play an exceptional role. The recent studies on similar type of waves - internal waves, have demonstrated the possibility of formation of natural wave attractors in the ocean (see [3] and references herein). This wave focusing leads to the emergence of strong three-wave interactions and subsequent flows mixing. We believe that similar phenomena can take place for inertial waves in rotating flows. In this work we present theoretical study of three-wave and four-wave interactions for inertial waves. As the main theoretical tool we suggest the complete Hamiltonian formalism for inertial waves in rotating incompressible fluids [4]. We study three-wave decay instability and then present statistical description of inertial waves in the frame of Hamiltonian formalism. We obtain kinetic equation, anisotropic wave turbulence spectra and study the problem of parametric wave turbulence. These spectra were previously found in [5] by helicity decomposition method. Taking this into account we discuss the advantages of suggested Hamiltonian formalism and its future applications. Andrey Gelash thanks support of the RFBR (Grant No.16-31-60086 mol_a_dk) and Dr. E. Ermanyuk, Dr. I. Sibgatullin for the fruitful discussions. [1] Le Gal, P. Waves and instabilities in rotating and stratified flows, Fluid Dynamics in Physics, Engineering and Environmental Applications. Springer Berlin Heidelberg, 25-40, 2013. [2] Greenspan, H. P. The theory of rotating fluids. CUP Archive, 1968. [3] Brouzet, C., Sibgatullin, I. N., Scolan, H., Ermanyuk, E

  6. Degradation of organic dyes using spray deposited nanocrystalline stratified WO3/TiO2 photoelectrodes under sunlight illumination

    Science.gov (United States)

    Hunge, Y. M.; Yadav, A. A.; Mahadik, M. A.; Bulakhe, R. N.; Shim, J. J.; Mathe, V. L.; Bhosale, C. H.

    2018-02-01

    The need to utilize TiO2 based metal oxide hetero nanostructures for the degradation of environmental pollutants like Rhodamine B and reactive red 152 from the wastewater using stratified WO3/TiO2 catalyst under sunlight illumination. WO3, TiO2 and stratified WO3/TiO2 catalysts were prepared by a spray pyrolysis method. It was found that the stratified WO3/TiO2 heterostructure has high crystallinity, no mixed phase formation occurs, strong optical absorption in the visible region of the solar spectrum, and large surface area. The photocatalytic activity was tested for degradation of Rhodamine B (Rh B) and reactive red 152 in an aqueous medium. TiO2 layer in stratified WO3/TiO2 catalyst helps to extend its absorption spectrum in the solar light region. Rh B and Reactive red 152is eliminated up to 98 and 94% within the 30 and 40 min respectively at optimum experimental condition by stratified WO3/TiO2. Moreover, stratified WO3/TiO2 photoelectrode has good stability and reusability than individual TiO2 and WO3 thin film in the degradation of Rh B and reactive red 152. The photoelectrocatalytic experimental results indicate that stratified WO3/TiO2 photoelectrode is a promising material for dye removal.

  7. The Values of Combined and Sub-Stratified Imaging Scores with Ultrasonography and Mammography in Breast Cancer Subtypes.

    Directory of Open Access Journals (Sweden)

    Tsun-Hou Chang

    Full Text Available The Breast Imaging Reporting and Data System (BI-RADS of Mammography (MG and Ultrasonography (US were equivalent to the "5-point score" and applied for combined and sub-stratified imaging assessments. This study evaluated the value of combined and sub-stratified imaging assessments with MG and US over breast cancer subtypes (BCS.Medical records of 5,037 cases having imaging-guided core biopsy, performed from 2009 to 2012, were retrospectively reviewed. This study selected 1,995 cases (1,457 benign and 538 invasive cancer having both MG and US before biopsy. These cases were categorized with the "5-point score" for their MG and US, and applied for combined and sub-stratified imaging assessments. Invasive cancers were classified on the basis of BCS, and correlated with combined and sub-stratified imaging assessments.These selected cases were evaluated by the "5-point score." MG, US, and combined and sub-stratified imaging assessments all revealed statistically significant (P < 0.001 incidence of malignancy. The sensitivity was increased in the combined imaging score (99.8%, and the specificity was increased in the sub-stratified combined score (75.4%. In the sub-stratified combined imaging assessment, all BCS can be classified with higher scores (abnormality hierarchy, and luminal B subtype showed the most salient result (hierarchy: higher, 95%; lower, 5%.Combined and sub-stratified imaging assessments can increase sensitivity and specificity of breast cancer diagnosis, respectively, and Luminal B subtype shows the best identification by sub-stratified combined imaging scoring.

  8. Analysis of flame propagation phenomenon in simplified stratified charge conditions; Tanjunkasareta sojo kyukiba ni okeru kaen denpa gensho no kansatsu

    Energy Technology Data Exchange (ETDEWEB)

    Moriyoshi, Y.; Morikawa, H. [Chiba University, Chiba (Japan); Kamimoto, T. [Tokyo Institute of Technology, Tokyo (Japan)

    1997-10-01

    Since the local inhomogeneity of mixture concentration inside the cylinder affects the combustion characteristics, a basic research on combustion phenomenon in stratified charge conditions is required. The authors have made experiments with a constant-volume chamber, which can simulate an idealized stratified charge field by using a removable partition, to obtain the combustion characteristics. Also, numerical calculations are made using some combustion models. As a result, the important feature that the combustion speed is faster in stratified condition than in homogeneous condition can be predicted by the two-step reaction model. 4 refs., 8 figs.

  9. Rapid shelf-wide cooling response of a stratified coastal ocean to hurricanes.

    Science.gov (United States)

    Seroka, Greg; Miles, Travis; Xu, Yi; Kohut, Josh; Schofield, Oscar; Glenn, Scott

    2017-06-01

    Large uncertainty in the predicted intensity of tropical cyclones (TCs) persists compared to the steadily improving skill in the predicted TC tracks. This intensity uncertainty has its most significant implications in the coastal zone, where TC impacts to populated shorelines are greatest. Recent studies have demonstrated that rapid ahead-of-eye-center cooling of a stratified coastal ocean can have a significant impact on hurricane intensity forecasts. Using observation-validated, high-resolution ocean modeling, the stratified coastal ocean cooling processes observed in two U.S. Mid-Atlantic hurricanes were investigated: Hurricane Irene (2011)-with an inshore Mid-Atlantic Bight (MAB) track during the late summer stratified coastal ocean season-and Tropical Storm Barry (2007)-with an offshore track during early summer. For both storms, the critical ahead-of-eye-center depth-averaged force balance across the entire MAB shelf included an onshore wind stress balanced by an offshore pressure gradient. This resulted in onshore surface currents opposing offshore bottom currents that enhanced surface to bottom current shear and turbulent mixing across the thermocline, resulting in the rapid cooling of the surface layer ahead-of-eye-center. Because the same baroclinic and mixing processes occurred for two storms on opposite ends of the track and seasonal stratification envelope, the response appears robust. It will be critical to forecast these processes and their implications for a wide range of future storms using realistic 3-D coupled atmosphere-ocean models to lower the uncertainty in predictions of TC intensities and impacts and enable coastal populations to better respond to increasing rapid intensification threats in an era of rising sea levels.

  10. Stratified premedication strategy for the prevention of contrast media hypersensitivity in high-risk patients.

    Science.gov (United States)

    Lee, Suh-Young; Yang, Min Suk; Choi, Young-Hoon; Park, Chang Min; Park, Heung-Woo; Cho, Sang Heon; Kang, Hye-Ryun

    2017-03-01

    Although the severity of hypersensitivity reactions to iodinated contrast media varies, it is well correlated with the severity of recurrent reactions; however, prophylaxis protocols are not severity-stratified. To assess the outcomes of tailored prophylaxis according to the severity of hypersensitivity reactions to iodinated contrast media. Our premedication protocols were stratified based on the severity of previous reactions: (1) 4 mg of chlorpheniramine for mild reactions, (2) adding 40 mg of methylprednisolone for moderate reactions, and (3) adding multiple doses of 40 mg of methylprednisolone for severe index reactions. Cases of reexposure in patients with a history of hypersensitivity reactions were routinely monitored and mandatorily recorded. Among a total of 850 patients who underwent enhanced computed tomography after severity-tailored prophylaxis, breakthrough reactions occurred in 17.1%, but most breakthrough reactions (89.0%) were mild and did not require medical treatment. Additional corticosteroid use did not reduce the breakthrough reaction rate in cases with a mild index reaction (16.8% vs 17.2%, P = .70). However, underpremedication with a single dose of corticosteroid revealed significantly higher rates of breakthrough reaction than did double doses of corticosteroid in cases with a severe index reaction (55.6% vs 17.4%, P = .02). Changing the iodinated contrast media resulted in an additional reduction of the breakthrough reaction rate overall (14.9% vs 32.1%, P = .001). In a total severity-based stratified prophylaxis regimens and changing iodinated contrast media can be considered in patients with a history of previous hypersensitivity reaction to iodinated contrast media to reduce the risk of breakthrough reactions. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  11. Rapid shelf‐wide cooling response of a stratified coastal ocean to hurricanes

    Science.gov (United States)

    Miles, Travis; Xu, Yi; Kohut, Josh; Schofield, Oscar; Glenn, Scott

    2017-01-01

    Abstract Large uncertainty in the predicted intensity of tropical cyclones (TCs) persists compared to the steadily improving skill in the predicted TC tracks. This intensity uncertainty has its most significant implications in the coastal zone, where TC impacts to populated shorelines are greatest. Recent studies have demonstrated that rapid ahead‐of‐eye‐center cooling of a stratified coastal ocean can have a significant impact on hurricane intensity forecasts. Using observation‐validated, high‐resolution ocean modeling, the stratified coastal ocean cooling processes observed in two U.S. Mid‐Atlantic hurricanes were investigated: Hurricane Irene (2011)—with an inshore Mid‐Atlantic Bight (MAB) track during the late summer stratified coastal ocean season—and Tropical Storm Barry (2007)—with an offshore track during early summer. For both storms, the critical ahead‐of‐eye‐center depth‐averaged force balance across the entire MAB shelf included an onshore wind stress balanced by an offshore pressure gradient. This resulted in onshore surface currents opposing offshore bottom currents that enhanced surface to bottom current shear and turbulent mixing across the thermocline, resulting in the rapid cooling of the surface layer ahead‐of‐eye‐center. Because the same baroclinic and mixing processes occurred for two storms on opposite ends of the track and seasonal stratification envelope, the response appears robust. It will be critical to forecast these processes and their implications for a wide range of future storms using realistic 3‐D coupled atmosphere‐ocean models to lower the uncertainty in predictions of TC intensities and impacts and enable coastal populations to better respond to increasing rapid intensification threats in an era of rising sea levels. PMID:28944132

  12. Using Pain Medication Intensity to Stratify Back Pain Among Older Adults.

    Science.gov (United States)

    Musich, Shirley; Wang, Shaohung S; Slindee, Luke B; Keown, Karen; Hawkins, Kevin; Yeh, Charlotte S

    2018-01-31

    To examine the prevalence of musculoskeletal back pain among older adults stratified by pain medication intensity to 1) review treatment patterns and 2) consider targeted back pain prevention interventions. A random sample of older adults age 64 years and older was utilized to identify new and recurring back pain. Prescription pain medications from drug claims were used to stratify to five unique intensity levels. The characteristics of each level were determined using regression models. About 10% had musculoskeletal back pain. Of these, 54% (N = 20,645) had new back pain and 46% (N = 17,252) had recurring back pain. Overall, about 35% received physical therapy. Pain medication intensity levels included no prescription pain medications, nonsteroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, low-dose opioids, and high-dose opioids (new back pain: 39%, 10%, 6%, 23%, and 23%, respectively; recurring back pain 32%, 9%, 4%, 17%, and 38%, respectively). NSAID and muscle relaxant users were younger, healthier, and received physical therapy. Opioid users were younger, in poorer health, used sleep medications, received physical therapy, and had more falls and higher health care utilization and expenditures.  New and recurring back pain patients can be stratified by pain medication intensity to review treatment patterns and target back pain prevention programs. Those with back pain but taking no prescription pain medications may benefit from back pain prevention programs. More research on guidelines for treatment options for those on high levels of pain medications is warranted. © 2018 American Academy of Pain Medicine.

  13. Development of a curved, stratified, in vitro model to assess ocular biocompatibility.

    Directory of Open Access Journals (Sweden)

    Cameron K Postnikoff

    Full Text Available PURPOSE: To further improve in vitro models of the cornea, this study focused on the creation of a three-dimensional, stratified, curved epithelium; and the subsequent characterization and evaluation of its suitability as a model for biocompatibility testing. METHODS: Immortalized human corneal epithelial cells were grown to confluency on curved cellulose filters for seven days, and were then differentiated and stratified using an air-liquid interface for seven days before testing. Varying concentrations of a commercial ophthalmic solution containing benzalkonium chloride (BAK, a known cytotoxic agent, and two relevant ocular surfactants were tested on the model. A whole balafilcon A lens soaked in phosphate buffered saline (BA PBS was also used to assess biocompatibility and verify the validity of the model. Viability assays as well as flow cytometry were performed on the cells to investigate changes in cell death and integrin expression. RESULTS: The reconstructed curved corneal epithelium was composed of 3-5 layers of cells. Increasing concentrations of BAK showed dose-dependent decreased cell viability and increased integrin expression and cell death. No significant change in viability was observed in the presence of the surfactants. As expected, the BA PBS combination appeared to be very biocompatible with no adverse change in cell viability or integrin expression. CONCLUSIONS: The stratified, curved, epithelial model proved to be sensitive to distinct changes in cytotoxicity and is suitable for continued assessment for biocompatibility testing of contact lenses. Our results showed that flow cytometry can provide a quantitative measure of the cell response to biomaterials or cytotoxic compounds for both the supernatant and adherent cell populations. As a specifically designed in vitro model of the corneal epithelium, this quantitative model for biocompatibility at the ocular surface may help improve our understanding of cell

  14. Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.

    Directory of Open Access Journals (Sweden)

    Tanya C Burch

    Full Text Available Type 1 diabetes (T1D and type 2 diabetes (T2D are associated with functional beta cell loss due to ongoing inflammation. Despite shared similarities, T1D is an autoimmune disease with evidence of autoantibody production, as well as a role for exocrine pancreas involvement. Our hypothesis is that differential protein expression occurs in disease stratified pancreas tissues and regulated proteins from endocrine and exocrine tissues are potential markers of disease and potential therapeutic targets. The study objective was to identify novel proteins that distinguish the pancreas from donors with T1D from the pancreas from patients with T2D, or autoantibody positive non-diabetic donors. Detailed quantitative comprehensive proteomic analysis was applied to snap frozen human pancreatic tissue lysates from organ donors without diabetes, with T1D-associated autoantibodies in the absence of diabetes, with T1D, or with T2D. These disease-stratified human pancreas tissues contain exocrine and endocrine tissues (with dysfunctional islets in the same microenvironment. The expression profiles of several of the proteins were further verified by western blot. We identified protein panels that are significantly and uniquely upregulated in the three disease-stratified pancreas tissues compared to non-disease control tissues. These proteins are involved in inflammation, metabolic regulation, and autoimmunity, all of which are pathways linked to, and likely involved in, T1 and T2 diabetes pathogenesis. Several new proteins were differentially upregulated in prediabetic, T1D, and T2D pancreas. The results identify proteins that could serve as novel prognostic, diagnostic, and therapeutic tools to preserve functional islet mass in Type 1 Diabetes.

  15. Hazardous fluid leak detector

    Science.gov (United States)

    Gray, Harold E.; McLaurin, Felder M.; Ortiz, Monico; Huth, William A.

    1996-01-01

    A device or system for monitoring for the presence of leaks from a hazardous fluid is disclosed which uses two electrodes immersed in deionized water. A gas is passed through an enclosed space in which a hazardous fluid is contained. Any fumes, vapors, etc. escaping from the containment of the hazardous fluid in the enclosed space are entrained in the gas passing through the enclosed space and transported to a closed vessel containing deionized water and two electrodes partially immersed in the deionized water. The electrodes are connected in series with a power source and a signal, whereby when a sufficient number of ions enter the water from the gas being bubbled through it (indicative of a leak), the water will begin to conduct, thereby allowing current to flow through the water from one electrode to the other electrode to complete the circuit and activate the signal.

  16. Rheology of Active Fluids

    Science.gov (United States)

    Saintillan, David

    2018-01-01

    An active fluid denotes a viscous suspension of particles, cells, or macromolecules able to convert chemical energy into mechanical work by generating stresses on the microscale. By virtue of this internal energy conversion, these systems display unusual macroscopic rheological signatures, including a curious transition to an apparent superfluid-like state where internal activity exactly compensates viscous dissipation. These behaviors are unlike those of classical complex fluids and result from the coupling of particle configurations with both externally applied flows and internally generated fluid disturbances. Focusing on the well-studied example of a suspension of microswimmers, this review summarizes recent experiments, models, and simulations in this area and highlights the critical role played by the rheological response of these active materials in a multitude of phenomena, from the enhanced transport of passive suspended objects to the emergence of spontaneous flows and collective motion.

  17. The application of economics concepts to stratified medicine--use of health economics data to support market access for stratified medicine interventions.

    Science.gov (United States)

    Fugel, Hans-Joerg; Nuijten, Mark; Faulkner, Eric

    2014-05-01

    Stratified medicine (SM), as opposed to empirical medicine, is the practice of using biomarkers or diagnostic tests to guide the choice of therapeutic treatments. The link between the diagnostic test and the therapy provides new opportunities for value creation and may strengthen the value proposition to pricing and reimbursement authorities. However, SM provides new challenges for the value assessment process, in particular health technology assessment (HTA) and pricing and reimbursement (P&R) decisions. Although health economics (HE) should be relevant for all stakeholders, not all stakeholders are comfortable with analysis/interpretation of economic data relevant to SM interventions as this approach is still in an early/emergent stage in most markets. This article addresses how different stakeholders are using health economic data in the overall value of information analysis to inform prioritization and reimbursement of SM interventions. Findings of an expert discussion outlines key challenges affecting various stakeholders when applying health economic data in the healthcare decision-making process for SM interventions.

  18. Exploring the salivary microbiome of children stratified by the oral hygiene index

    OpenAIRE

    Mashima, Izumi; Theodorea, Citra F.; Thaweboon, Boonyanit; Thaweboon, Sroisiri; Scannapieco, Frank A.; Nakazawa, Futoshi

    2017-01-01

    Poor oral hygiene often leads to chronic diseases such as periodontitis and dental caries resulting in substantial economic costs and diminished quality of life in not only adults but also in children. In this study, the salivary microbiome was characterized in a group of children stratified by the Simplified Oral Hygiene Index (OHI-S). Illumina MiSeq high-throughput sequencing based on the 16S rRNA was utilized to analyze 90 salivary samples (24 Good, 31 Moderate and 35 Poor oral hygiene) fr...

  19. Interfacial shear stress in stratified flow in a horizontal rectangular duct

    Energy Technology Data Exchange (ETDEWEB)

    Lorencez, C.; Kawaji, M. [Univ. of Toronto (Canada); Murao, Y. [Tokushima Univ. (Japan)] [and others

    1995-09-01

    Interfacial shear stress has been experimentally examined for both cocurrent and countercurrent stratified wavy flows in a horizontal interfacial shear stress from the measurements were examined and the results have been compared with existing correlations. Some differences were found in the estimated interfacial shear stress from the measurements were examined and the results have been compared with existing correlations. Some differences were found in the estimated interfacial shear stress values at high gas flow rates which could be attributed to the assumptions and procedures involved in each method. The interfacial waves and secondary motions were also found to have significant effects on the accuracy of Reynolds stress and turbulence kinetic energy extrapolation methods.

  20. Expression of GLUT1 in stratified squamous epithelia and oral carcinoma from humans and rats

    DEFF Research Database (Denmark)

    Voldstedlund, M; Dabelsteen, Erik

    1997-01-01

    Most cells express facilitative glucose transporters. Four isoforms (GLUT1-4) transporting D-glucose across the plasma membrane show a specific tissue distribution, which is the basis for tissue-specific patterns in glucose metabolism. GLUT1 is expressed at high levels in tissue barriers...... as a general indicator of tissue barriers. In contrast, our results support the prevailing, but limited knowledge of glucose metabolism in squamous stratified epithelia, a metabolism believed to depend mostly on glycolysis, especially in the basal layers. High-level expression seemed to be confined...

  1. Keeping the customers stratified: moving toward genetics-based treatment options in childhood NS.

    Science.gov (United States)

    Puckelwartz, Megan; Schnaper, H William

    2017-04-01

    In this issue, Bierzynska et al. report the results of analyzing a cohort of children with steroid-resistant nephrotic syndrome (SRNS) of childhood, correlating genetic studies with clinical outcomes. This approach has the potential to advance both our research into the causes and treatments of childhood SRNS and our ability to stratify patients into groups that are likely to be responsive to specific treatments. Here, we discuss some of the strengths and limitations of this report. Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  2. MUP, CEC-DES, STRADE. Codes for uncertainty propagation, experimental design and stratified random sampling techniques

    International Nuclear Information System (INIS)

    Amendola, A.; Astolfi, M.; Lisanti, B.

    1983-01-01

    The report describes the how-to-use of the codes: MUP (Monte Carlo Uncertainty Propagation) for uncertainty analysis by Monte Carlo simulation, including correlation analysis, extreme value identification and study of selected ranges of the variable space; CEC-DES (Central Composite Design) for building experimental matrices according to the requirements of Central Composite and Factorial Experimental Designs; and, STRADE (Stratified Random Design) for experimental designs based on the Latin Hypercube Sampling Techniques. Application fields, of the codes are probabilistic risk assessment, experimental design, sensitivity analysis and system identification problems

  3. The anatomy of the mixing transition in homogeneous and stratified free shear layers

    Science.gov (United States)

    Caulfield, C. P.; Peltier, W. R.

    2000-06-01

    We investigate the detailed nature of the ‘mixing transition’ through which turbulence may develop in both homogeneous and stratified free shear layers. Our focus is upon the fundamental role in transition, and in particular the associated ‘mixing’ (i.e. small-scale motions which lead to an irreversible increase in the total potential energy of the flow) that is played by streamwise vortex streaks, which develop once the primary and typically two-dimensional Kelvin Helmholtz (KH) billow saturates at finite amplitude.

  4. Performance and combustion characteristics of direct-injection stratified-charge rotary engines

    Science.gov (United States)

    Nguyen, Hung Lee

    1987-01-01

    Computer simulations of the direct-injection stratified-charge (DISC) Wankel engine have been used to calculate heat release rates and performance and efficiency characteristics of the 1007R engine. Engine pressure data have been used in a heat release analysis to study the effects of heat transfer, leakage, and crevice flows. Predicted engine performance data are compared with experimental test data over a range of engine speeds and loads. An examination of methods to improve the performance of the Wankel engine with faster combustion, reduced leakage, higher compression ratio, and turbocharging is presented.

  5. Partially coherent light propagation in stratified media containing an optically thick anisotropic layer

    Science.gov (United States)

    Nichols, Shane M.; Arteaga, Oriol; Martin, Alexander T.; Kahr, Bart

    2017-11-01

    Methods used to compute the reflection or transmission Mueller matrix of stratified media assume light is a monochromatic plane wave, but measurements with spectroscopic devices invariably involve a finite distribution of wavelengths and incidence angles. Consequently, there can be stark disagreement between calculation and experiment, especially when the specimen includes a thick non-opaque layer. To accurately model specimens with a thick layer, it is sometimes necessary to explicitly include the coherence of the light in models. For anisotropic and/or optically active media, we distinguish between five regimes of coherence. Algebraic expressions valid for all regimes are given. Experimental data spanning multiple regimes is modeled.

  6. Dynamics of the free surface of stratified two-phase flows in channels with rectangular cross-sections

    Energy Technology Data Exchange (ETDEWEB)

    Vallee, Christophe

    2012-08-22

    Stratified two-phase flows were investigated at different test facilities with horizontal test sections in order to provide an experimental database for the development and validation of computational fluid dynamics (CFD) codes. These channels were designed with rectangular cross-sections to enable optimal observation conditions for the application of optical measurement techniques. Consequently, the local flow structure was visualised with a high-speed video camera, delivering data with highresolution in space and time as needed for CFD code validation. Generic investigations were performed at atmospheric pressure and room temperature in two air/water channels made of acrylic glass. Divers preliminary experiments were conducted with various measuring systems in a test section mounted between two separators. The second test facility, the Horizontal Air/Water Channel (HAWAC), is dedicated to co-current flow investigations. The hydraulic jump as the quasi-stationary discontinuous transition between super- and subcritical flow was studied in this closed channel. Moreover, the instable wave growth leading to slug flow was investigated from the test section inlet. For quantitative analysis of the optical measurements, an algorithm was developed to recognise the stratified interface in the camera frames, allowing statistical treatments for comparison with CFD calculation results. The third test apparatus was installed in the pressure chamber of the TOPFLOW test facility in order to be operated at reactor typical conditions under pressure equilibrium with the vessel atmosphere. The test section representing a flat model of the hot leg of the German Konvoi pressurised water reactor (PWR) scaled at 1:3 is equipped with large glass side walls in the region of the elbow and of the steam generator inlet chamber to allow visual observations. The experiments were conducted with air and water at room temperature and maximum pressures of 3 bar as well as with steam and water at

  7. Dynamics of the free surface of stratified two-phase flows in channels with rectangular cross-sections

    International Nuclear Information System (INIS)

    Vallee, Christophe

    2012-01-01

    Stratified two-phase flows were investigated at different test facilities with horizontal test sections in order to provide an experimental database for the development and validation of computational fluid dynamics (CFD) codes. These channels were designed with rectangular cross-sections to enable optimal observation conditions for the application of optical measurement techniques. Consequently, the local flow structure was visualised with a high-speed video camera, delivering data with highresolution in space and time as needed for CFD code validation. Generic investigations were performed at atmospheric pressure and room temperature in two air/water channels made of acrylic glass. Divers preliminary experiments were conducted with various measuring systems in a test section mounted between two separators. The second test facility, the Horizontal Air/Water Channel (HAWAC), is dedicated to co-current flow investigations. The hydraulic jump as the quasi-stationary discontinuous transition between super- and subcritical flow was studied in this closed channel. Moreover, the instable wave growth leading to slug flow was investigated from the test section inlet. For quantitative analysis of the optical measurements, an algorithm was developed to recognise the stratified interface in the camera frames, allowing statistical treatments for comparison with CFD calculation results. The third test apparatus was installed in the pressure chamber of the TOPFLOW test facility in order to be operated at reactor typical conditions under pressure equilibrium with the vessel atmosphere. The test section representing a flat model of the hot leg of the German Konvoi pressurised water reactor (PWR) scaled at 1:3 is equipped with large glass side walls in the region of the elbow and of the steam generator inlet chamber to allow visual observations. The experiments were conducted with air and water at room temperature and maximum pressures of 3 bar as well as with steam and water at

  8. Computational fluid dynamics

    CERN Document Server

    Magoules, Frederic

    2011-01-01

    Exploring new variations of classical methods as well as recent approaches appearing in the field, Computational Fluid Dynamics demonstrates the extensive use of numerical techniques and mathematical models in fluid mechanics. It presents various numerical methods, including finite volume, finite difference, finite element, spectral, smoothed particle hydrodynamics (SPH), mixed-element-volume, and free surface flow.Taking a unified point of view, the book first introduces the basis of finite volume, weighted residual, and spectral approaches. The contributors present the SPH method, a novel ap

  9. On radiative fluids

    International Nuclear Information System (INIS)

    Straumann, N.

    1976-01-01

    The Thomas calculation of the energy-momentum tensor of radiation quanta, which are nearly in thermal equilibrium with a relativistically moving material medium, is simplified and extended to more general transport equations. It is shown that the fluid (matter plus radiation) behaves, independently of the detailed form of the Boltzmann equation, like a relativistic imperfect fluid (in the formulation of Eckart). General expressions for the coefficients of heat conduction, shear viscosity and bulk viscosity are given. Published formulae for these coefficients in special cases are corrected. (Auth.)

  10. Mechanics of fluid flow

    CERN Document Server

    Basniev, Kaplan S; Chilingar, George V 0

    2012-01-01

    The mechanics of fluid flow is a fundamental engineering discipline explaining both natural phenomena and human-induced processes, and a thorough understanding of it is central to the operations of the oil and gas industry.  This book, written by some of the world's best-known and respected petroleum engineers, covers the concepts, theories, and applications of the mechanics of fluid flow for the veteran engineer working in the field and the student, alike.  It is a must-have for any engineer working in the oil and gas industry.

  11. National Coral Reef Monitoring Program: Benthic Images Collected from Stratified Random Sites (StRS) across American Samoa in 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data described here are benthic habitat imagery that result from benthic photo-quadrat surveys conducted along transects at stratified random sites across...

  12. Diagnostic accuracy of the STRATIFY clinical prediction rule for falls: A systematic review and meta-analysis

    LENUS (Irish Health Repository)

    Billington, Jennifer

    2012-08-07

    AbstractBackgroundThe STRATIFY score is a clinical prediction rule (CPR) derived to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall diagnostic accuracy of the STRATIFY rule across a variety of clinical settings.MethodsA literature search was performed to identify all studies that validated the STRATIFY rule. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A STRATIFY score of ≥2 points was used to identify individuals at higher risk of falling. All included studies were combined using a bivariate random effects model to generate pooled sensitivity and specificity of STRATIFY at ≥2 points. Heterogeneity was assessed using the variance of logit transformed sensitivity and specificity.ResultsSeventeen studies were included in our meta-analysis, incorporating 11,378 patients. At a score ≥2 points, the STRATIFY rule is more useful at ruling out falls in those classified as low risk, with a greater pooled sensitivity estimate (0.67, 95% CI 0.52–0.80) than specificity (0.57, 95% CI 0.45 – 0.69). The sensitivity analysis which examined the performance of the rule in different settings and subgroups also showed broadly comparable results, indicating that the STRATIFY rule performs in a similar manner across a variety of different ‘at risk’ patient groups in different clinical settings.ConclusionThis systematic review shows that the diagnostic accuracy of the STRATIFY rule is limited and should not be used in isolation for identifying individuals at high risk of falls in clinical practice.

  13. Second-moment closures and length scales for weakly stratified turbulent shear flows

    Science.gov (United States)

    Baumert, Helmut; Peters, Hartmut

    2000-03-01

    For the special hydrodynamic situation of unbounded homogeneous shear layers, turbulence closure models of Mellor-Yamada type (MY) and k-ɛ type are put into a single canonical form. For this situation we show that conventional versions of MY and various k-ɛ versions lack a proper steady state, and are unable to simulate the most basic properties of stratified shear flows exemplified in, for example, the Rohr et al. [1988] experiments: exponential growth at sufficiently low gradient Richardson number (Rg), exponential decay at sufficiently large Rg, and a steady state in between. Proper choice of one special model parameter readily solves the problems. In the fairly general case of structural equilibrium (state of exponential evolution) in weakly to moderately stratified turbulence (Rg ≲ 0.25), the ratio between the Thorpe scale (or Ellison scale) and the Ozmidov scale varies like the gradient Richardson number (Rg) to the power 3/4, and the ratio of the Thorpe scale to the buoyancy scale varies like Rg1/2. Length scales predicted by our current model are consistent with laboratory measurements of Rohr et al. [1988], with large-eddy numerical simulations of Schumann and Gerz [1995], and with microstructure measurements from the 1987 Tropic Heat Experiment in the equatorial Pacific by Peters et al. [1995].

  14. Non-local effects in a stratified glow discharge with dust particles

    Energy Technology Data Exchange (ETDEWEB)

    Sukhinin, G I; Fedoseev, A V [Institute of Thermophysics SB RAS, Lavrentyev Ave., 1, Novosibirsk, 630090 (Russian Federation); Ramazanov, T S; Amangaliyeva, R Zh; Dosbalayev, M K; Jumabekov, A N [Institute of Experimental and Theoretical Physics, Al Farabi Kazakh National University, Tole Bi, 96a, Almaty, 050012 (Kazakhstan)], E-mail: fedoseev@itp.nsc.ru

    2008-12-21

    The work is aimed at describing non-local effects in the positive column of a low-pressure stratified dc glow discharge in argon with dust particles in a vertical cylindrical discharge tube. Numerical calculations of plasma parameters in the axis of the discharge tube were performed with the help of a hybrid model based on the solution of a non-local Boltzmann equation for electron energy distribution function (EEDF). Axial distributions of optical emission from striations with dust particles were measured experimentally. Negatively charged dust particles in a low-pressure stratified gas discharge should levitate at the anode-side branch of an electric field distribution above its maximum. At the same time the experiments showed that the dust particles levitate at the cathode side of a stratum. This paradox is explained by the fact that in a low-pressure striated discharge the optical emission distribution is displaced relative to the electric field distribution that was shown both by numerical simulations and experimental measurements.

  15. Self-regulation of mean flows in strongly stratified sheared turbulence

    Science.gov (United States)

    Salehipour, Hesam; Caulfield, Colm-Cille; Peltier, W. Richard

    2016-11-01

    We investigate the near-equilibrium state of shear-driven stratified turbulence generated by the breaking of Holmboe wave instability (HWI) and Kelvin-Helmholtz instability (KHI). We discuss DNS analyses associated with HWI under various initial conditions. We analyze the time-dependent distribution of the gradient Richardson number, Rig (z , t) associated with the horizontally-averaged velocity and density fields. We demonstrate that unlike the KHI-induced turbulence, the fully turbulent flow that is generated by HWI is robustly characterized by its high probability of Rig 0 . 2 - 0 . 25 , independent of the strength of the initial stratification and furthermore that the turbulence evolves in a 'near-equilibrium' state. The KHI-induced turbulence may become grossly 'out of equilibrium', however, and therefore decays rapidly when the initial value at the interface, Rig (0 , 0) , is closer to the critical value of 1/4; otherwise as Rig (0 , 0) -> 0 the KHI-induced turbulence is close to a state of equilibrium and hence is much more long-lived. We conjecture that stratified shear turbulence tends to adjust to a state of 'near-equilibrium' with horizontally-averaged flows characterized by a high probability of Rig <= 1 / 4 , and hence sustained turbulence over relatively long times.

  16. Par6b Regulates the Dynamics of Apicobasal Polarity during Development of the Stratified Xenopus Epidermis

    Science.gov (United States)

    Wang, Sha; Cha, Sang-Wook; Zorn, Aaron M.; Wylie, Christopher

    2013-01-01

    During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis. This process has been mostly studied in simple epithelia that have only one layer of cells, but is poorly understood in stratified epithelia. In this paper we address the role of the polarity protein Partitioning defective-6 homolog beta (Par6b) in the developing stratified epidermis of Xenopus laevis. At the blastula stage, animal blastomeres divide perpendicularly to the apicobasal axis to generate partially polarized superficial cells and non-polarized deep cells. Both cell populations modify their apicobasal polarity during the gastrula stage, before differentiating into the superficial and deep layers of epidermis. Early differentiation of the epidermis is normal in Par6b-depleted embryos; however, epidermal cells dissociate and detach from embryos at the tailbud stage. Par6b-depleted epidermal cells exhibit a significant reduction in basolaterally localized E-cadherin. Examination of the apical marker Crumbs homolog 3 (Crb3) and the basolateral marker Lethal giant larvae 2 (Lgl2) after Par6b depletion reveals that Par6b cell-autonomously regulates the dynamics of apicobasal polarity in both superficial and deep epidermal layers. Par6b is required to maintain the “basolateral” state in both epidermal layers, which explains the reduction of basolateral adhesion complexes and epidermal cells shedding. PMID:24204686

  17. Characterizing the performance of an affordable, multichannel conductivity probe for density measurements in stratified flows

    Science.gov (United States)

    Subramanian, Balaji; Carminati, Marco; Luzzatto-Fegiz, Paolo

    2017-11-01

    In stratified flows, conductivity (combined with temperature) is often used to measure density. The conductivity probes typically used can resolve very fine spatial scales, but on the downside they are fragile, expensive, sensitive to environmental noise and have only single channel capability. Recently a low-cost, robust, arduino-based probe called Conduino was developed, which can be valuable in a wide range of applications where resolving extremely small spatial scales is not needed. This probe uses micro-USB connectors as actual conductivity sensors with a custom designed electronic board for simultaneous acquisition from multiple probes, with conductivity resolution comparable to commercially available PME conductivity probe. A detailed assessment of performance of this Conduino probe is described here. To establish time response and sensitivity as a function of electrode geometry, we build a variety of shapes for different kinds of applications, with tip spacing ranging from 0.5-2.5 mm, and with electrode length ranging from 2.3-6 mm. We set up a two-layer density profile and traverse it rapidly, yielding a time response comparable to PME. The Conduino's multi-channel capability is used to operate probe arrays, which helps to construct density fields in stratified flows.

  18. Sleep disturbance at simulated altitude indicated by stratified respiratory disturbance index but not hypoxic ventilatory response.

    Science.gov (United States)

    Kinsman, Tahnee A; Townsend, Nathan E; Gore, Christopher J; Hahn, Allan G; Clark, Sally A; Aughey, Robert J; McKenna, Michael J; Hawley, John A; Chow, Chin-Moi

    2005-08-01

    At high altitudes, the clinically defined respiratory disturbance index (RDI) and high hypoxic ventilatory response (HVR) have been associated with diminished sleep quality. Increased RDI has also been observed in some athletes sleeping at simulated moderate altitude. In this study, we investigated relationships between the HVR of 14 trained male endurance cyclists with variable RDI and sleep quality responses to simulated moderate altitude. Blood oxygen saturation (SpO2%), heart rate, RDI, arousal rate, awakenings, sleep efficiency, rapid eye movement (REM) sleep, non-REM sleep stages 1, 2 and slow wave sleep as percentages of total sleep time (%TST) were measured for two nights at normoxia of 600 m and one night at a simulated altitude of 2,650 m. HVR and RDI were not significantly correlated with sleep stage, arousal rate or awakening response to nocturnal simulated altitude. SpO2 was inversely correlated with total RDI (r = -0.69, P = 0.004) at simulated altitude and with the change in arousal rate from normoxia (r = -0.65, P = 0.02). REM sleep response to simulated altitude correlated with the change, relative to normoxia, in arousal (r = -0.63, P = 0.04) and heart rate (r = -0.61, P = 0.04). When stratified, those athletes at altitude with RDI >20 h(-1) (n = 4) and those with sleep or arousal increase. However, the stratified RDI provides a basis for determining potential sleep disturbance in athletes at simulated moderate altitude.

  19. Cascaded plasmon-plasmon coupling mediated energy transfer across stratified metal-dielectric nanostructures.

    Science.gov (United States)

    Golmakaniyoon, Sepideh; Hernandez-Martinez, Pedro Ludwig; Demir, Hilmi Volkan; Sun, Xiao Wei

    2016-10-04

    Surface plasmon (SP) coupling has been successfully applied to nonradiative energy transfer via exciton-plasmon-exciton coupling in conventionally sandwiched donor-metal film-acceptor configurations. However, these structures lack the desired efficiency and suffer poor photoemission due to the high energy loss. Here, we show that the cascaded exciton-plasmon-plasmon-exciton coupling in stratified architecture enables an efficient energy transfer mechanism. The overlaps of the surface plasmon modes at the metal-dielectric and dielectric-metal interfaces allow for strong cross-coupling in comparison with the single metal film configuration. The proposed architecture has been demonstrated through the analytical modeling and numerical simulation of an oscillating dipole near the stratified nanostructure of metal-dielectric-metal-acceptor. Consistent with theoretical and numerical results, experimental measurements confirm at least 50% plasmon resonance energy transfer enhancement in the donor-metal-dielectric-metal-acceptor compared to the donor-metal-acceptor structure. Cascaded plasmon-plasmon coupling enables record high efficiency for exciton transfer through metallic structures.

  20. Multi-Instrument Observations of Prolonged Stratified Wind Layers at Iqaluit, Nunavut

    Science.gov (United States)

    Mariani, Zen; Dehghan, Armin; Gascon, Gabrielle; Joe, Paul; Hudak, David; Strawbridge, Kevin; Corriveau, Julien

    2018-02-01

    Data collected between October 2015 and May 2016 at Environment and Climate Change Canada's Iqaluit research site (64°N, 69°W) have revealed a high frequency (40% of all days for which observations were available) of stratified wind layer events that occur from near the surface up to about 7.2 km above sea level. These stratified wind layers are clearly visible as wind shifts (90 to 180°) with height in range-height indicator scans from the Doppler lidar and Ka-band radar and in wind direction profiles from the Doppler lidar and radiosonde. During these events, the vertical structure of the flow appears to be a stack of 4 to 10 layers ranging in vertical width from 0.1 to 4.4 km. The stratification events that were observed occurred predominantly (81%) during light precipitation and lasted up to 27.5 h. The integrated measurement platforms at Iqaluit permitted continuous observations of the evolution of stratification events in different meteorological conditions.

  1. Robust computation of dipole electromagnetic fields in arbitrarily anisotropic, planar-stratified environments.

    Science.gov (United States)

    Sainath, Kamalesh; Teixeira, Fernando L; Donderici, Burkay

    2014-01-01

    We develop a general-purpose formulation, based on two-dimensional spectral integrals, for computing electromagnetic fields produced by arbitrarily oriented dipoles in planar-stratified environments, where each layer may exhibit arbitrary and independent anisotropy in both its (complex) permittivity and permeability tensors. Among the salient features of our formulation are (i) computation of eigenmodes (characteristic plane waves) supported in arbitrarily anisotropic media in a numerically robust fashion, (ii) implementation of an hp-adaptive refinement for the numerical integration to evaluate the radiation and weakly evanescent spectra contributions, and (iii) development of an adaptive extension of an integral convergence acceleration technique to compute the strongly evanescent spectrum contribution. While other semianalytic techniques exist to solve this problem, none have full applicability to media exhibiting arbitrary double anisotropies in each layer, where one must account for the whole range of possible phenomena (e.g., mode coupling at interfaces and nonreciprocal mode propagation). Brute-force numerical methods can tackle this problem but only at a much higher computational cost. The present formulation provides an efficient and robust technique for field computation in arbitrary planar-stratified environments. We demonstrate the formulation for a number of problems related to geophysical exploration.

  2. Hierarchical spatial capture-recapture models: Modeling population density from stratified populations

    Science.gov (United States)

    Royle, J. Andrew; Converse, Sarah J.

    2014-01-01

    Capture–recapture studies are often conducted on populations that are stratified by space, time or other factors. In this paper, we develop a Bayesian spatial capture–recapture (SCR) modelling framework for stratified populations – when sampling occurs within multiple distinct spatial and temporal strata.We describe a hierarchical model that integrates distinct models for both the spatial encounter history data from capture–recapture sampling, and also for modelling variation in density among strata. We use an implementation of data augmentation to parameterize the model in terms of a latent categorical stratum or group membership variable, which provides a convenient implementation in popular BUGS software packages.We provide an example application to an experimental study involving small-mammal sampling on multiple trapping grids over multiple years, where the main interest is in modelling a treatment effect on population density among the trapping grids.Many capture–recapture studies involve some aspect of spatial or temporal replication that requires some attention to modelling variation among groups or strata. We propose a hierarchical model that allows explicit modelling of group or strata effects. Because the model is formulated for individual encounter histories and is easily implemented in the BUGS language and other free software, it also provides a general framework for modelling individual effects, such as are present in SCR models.

  3. 'Timed Up and Go' test: Age, gender and cognitive impairment stratified normative values of older adults.

    Directory of Open Access Journals (Sweden)

    Azianah Ibrahim

    Full Text Available The aim of this study was to establish 'Timed up and Go' test (TUG normative data among community dwelling older adults stratified based on cognitive status, gender and age groups.A total of 2084 community dwelling older adults from wave I and II were recruited through a multistage random sampling method. TUG was performed using the standard protocol and scores were then stratified based on with and without mild cognitive impairment (MCI, gender and in a 5-year age groups ranging from ages of 60's to 80's.529(16% participants were identified to have MCI. Past history of falls and medical history of hypertension, heart disease, joint pain, hearing and vision problem, and urinary incontinence were found to have influenced TUG performance. Cognitive status as a mediator, predicted TUG performance even when both gender and age were controlled for (B 0.24, 95% CI (0.02-0.47, β 0.03, t 2.10, p = 0.36. Further descriptive analysis showed, participants with MCI, women and older in age took a longer time to complete TUG, as compared to men with MCI across all age groups with exceptions for some age groups.These results suggested that MCI needs to be taken into consideration when testing older adults using TUG, besides age and gender factors. Data using fast speed TUG may be required among older adults with and without MCI for further understanding.

  4. [Study of spatial stratified sampling strategy of Oncomelania hupensis snail survey based on plant abundance].

    Science.gov (United States)

    Xun-Ping, W; An, Z

    2017-07-27

    Objective To optimize and simplify the survey method of Oncomelania hupensis snails in marshland endemic regions of schistosomiasis, so as to improve the precision, efficiency and economy of the snail survey. Methods A snail sampling strategy (Spatial Sampling Scenario of Oncomelania based on Plant Abundance, SOPA) which took the plant abundance as auxiliary variable was explored and an experimental study in a 50 m×50 m plot in a marshland in the Poyang Lake region was performed. Firstly, the push broom surveyed data was stratified into 5 layers by the plant abundance data; then, the required numbers of optimal sampling points of each layer through Hammond McCullagh equation were calculated; thirdly, every sample point in the line with the Multiple Directional Interpolation (MDI) placement scheme was pinpointed; and finally, the comparison study among the outcomes of the spatial random sampling strategy, the traditional systematic sampling method, the spatial stratified sampling method, Sandwich spatial sampling and inference and SOPA was performed. Results The method (SOPA) proposed in this study had the minimal absolute error of 0.213 8; and the traditional systematic sampling method had the largest estimate, and the absolute error was 0.924 4. Conclusion The snail sampling strategy (SOPA) proposed in this study obtains the higher estimation accuracy than the other four methods.

  5. Men's Health Index: a pragmatic approach to stratifying and optimizing men's health.

    Science.gov (United States)

    Tan, Hui Meng; Tan, Wei Phin; Wong, Jun Hoe; Ho, Christopher Chee Kong; Teo, Chin Hai; Ng, Chirk Jenn

    2014-11-01

    The proposed Men's Health Index (MHI) aims to provide a practical and systematic framework for comprehensively assessing and stratifying older men with the intention of optimising their health and functional status. A literature search was conducted using PubMed from 1980 to 2012. We specifically looked for instruments which: assess men's health, frailty and fitness; predict life expectancy, mortality and morbidities. The instruments were assessed by the researchers who then agreed on the tools to be included in the MHI. When there was disagreements, the researchers discussed and reached a consensus guided by the principle that the MHI could be used in the primary care setting targetting men aged 55-65 years. The instruments chosen include the Charlson's Combined Comorbidity-Age Index; the International Index of Erectile Function-5; the International Prostate Symptom Score; the Androgen Deficiency in Aging Male; the Survey of Health, Ageing and Retirement in Europe Frailty Instrument; the Sitting-Rising Test; the Senior Fitness Test; the Fitness Assessment Score; and the Depression Anxiety Stress Scale-21. A pilot test on eight men was carried out and showed that the men's health index is viable. The concept of assessing, stratifying, and optimizing men's health should be incorporated into routine health care, and this can be implemented by using the MHI. This index is particularly useful to primary care physicians who are in a strategic position to engage men at the peri-retirement age in a conversation about their life goals based on their current and predicted health status.

  6. Fundamental Fluid Mechanics

    Indian Academy of Sciences (India)

    umes by P N Chatterjee contains standard material for a first level course in fluid me- chanics for Civil, Mechanical, Aeronautical and Chemical Engineering students. It is however not suitable for Applied Science students like those majoring in Physics or. Mathematics and is not a good reference book for practising ...

  7. Relativistic viscoelastic fluid mechanics.

    Science.gov (United States)

    Fukuma, Masafumi; Sakatani, Yuho

    2011-08-01

    A detailed study is carried out for the relativistic theory of viscoelasticity which was recently constructed on the basis of Onsager's linear nonequilibrium thermodynamics. After rederiving the theory using a local argument with the entropy current, we show that this theory universally reduces to the standard relativistic Navier-Stokes fluid mechanics in the long time limit. Since effects of elasticity are taken into account, the dynamics at short time scales is modified from that given by the Navier-Stokes equations, so that acausal problems intrinsic to relativistic Navier-Stokes fluids are significantly remedied. We in particular show that the wave equations for the propagation of disturbance around a hydrostatic equilibrium in Minkowski space-time become symmetric hyperbolic for some range of parameters, so that the model is free of acausality problems. This observation suggests that the relativistic viscoelastic model with such parameters can be regarded as a causal completion of relativistic Navier-Stokes fluid mechanics. By adjusting parameters to various values, this theory can treat a wide variety of materials including elastic materials, Maxwell materials, Kelvin-Voigt materials, and (a nonlinearly generalized version of) simplified Israel-Stewart fluids, and thus we expect the theory to be the most universal description of single-component relativistic continuum materials. We also show that the presence of strains and the corresponding change in temperature are naturally unified through the Tolman law in a generally covariant description of continuum mechanics.

  8. Incompressible ionized fluid mixtures

    Czech Academy of Sciences Publication Activity Database

    Roubíček, Tomáš

    2006-01-01

    Roč. 17, č. 7 (2006), s. 493-509 ISSN 0935-1175 Institutional research plan: CEZ:AV0Z10750506 Keywords : chemically reacting fluids * Navier-Stokes * Nernst-Planck * Possion equation s * heat equation s Subject RIV: BA - General Mathematics Impact factor: 0.954, year: 2006

  9. Bouncy Fluid Jets

    Science.gov (United States)

    Wadhwa, Navish; Jung, Sunghwan; Vlachos, Pavlos

    2012-11-01

    Contrary to intuition, free fluid jets can sometimes ``bounce'' off each other upon collision, due to an entrained air film that keeps them separated. So far, there have only been a few descriptive studies of bouncing jets, since the first recorded observation by Rayleigh more than a century ago. We present a quantitative investigation of non-coalescence in jets of same fluid upon an oblique collision. Using a simple experimental set-up, we carried out a parametric study of the bouncing jets by varying the jet diameter, velocity, angle of inclination and fluid viscosity. Our results reveal a scaling law for the contact time of bouncing jets. We further investigate the transition of colliding jets from non-coalescence to coalescence, which seems to be caused by instability of the fluid interface. A dimensionless parameter, which is a function of the Normal Weber Number, Normal Reynolds Number and the angle of inclination of the jets, quantitatively dictates the transition. Presently at Department of Physics, Danish Technical University, Denmark.

  10. Relativistic viscoelastic fluid mechanics

    International Nuclear Information System (INIS)

    Fukuma, Masafumi; Sakatani, Yuho

    2011-01-01

    A detailed study is carried out for the relativistic theory of viscoelasticity which was recently constructed on the basis of Onsager's linear nonequilibrium thermodynamics. After rederiving the theory using a local argument with the entropy current, we show that this theory universally reduces to the standard relativistic Navier-Stokes fluid mechanics in the long time limit. Since effects of elasticity are taken into account, the dynamics at short time scales is modified from that given by the Navier-Stokes equations, so that acausal problems intrinsic to relativistic Navier-Stokes fluids are significantly remedied. We in particular show that the wave equations for the propagation of disturbance around a hydrostatic equilibrium in Minkowski space-time become symmetric hyperbolic for some range of parameters, so that the model is free of acausality problems. This observation suggests that the relativistic viscoelastic model with such parameters can be regarded as a causal completion of relativistic Navier-Stokes fluid mechanics. By adjusting parameters to various values, this theory can treat a wide variety of materials including elastic materials, Maxwell materials, Kelvin-Voigt materials, and (a nonlinearly generalized version of) simplified Israel-Stewart fluids, and thus we expect the theory to be the most universal description of single-component relativistic continuum materials. We also show that the presence of strains and the corresponding change in temperature are naturally unified through the Tolman law in a generally covariant description of continuum mechanics.

  11. Cryogenic Fluid Management Facility

    Science.gov (United States)

    Eberhardt, R. N.; Bailey, W. J.

    1985-01-01

    The Cryogenic Fluid Management Facility is a reusable test bed which is designed to be carried within the Shuttle cargo bay to investigate the systems and technologies associated with the efficient management of cryogens in space. Cryogenic fluid management consists of the systems and technologies for: (1) liquid storage and supply, including capillary acquisition/expulsion systems which provide single-phase liquid to the user system, (2) both passive and active thermal control systems, and (3) fluid transfer/resupply systems, including transfer lines and receiver tanks. The facility contains a storage and supply tank, a transfer line and a receiver tank, configured to provide low-g verification of fluid and thermal models of cryogenic storage and transfer processes. The facility will provide design data and criteria for future subcritical cryogenic storage and transfer system applications, such as Space Station life support, attitude control, power and fuel depot supply, resupply tankers, external tank (ET) propellant scavenging, and ground-based and space-based orbit transfer vehicles (OTV).

  12. Fluids in metamorphic rocks

    NARCIS (Netherlands)

    Touret, J.L.R.

    2001-01-01

    Basic principles for the study of fluid inclusions in metamorphic rocks are reviewed and illustrated. A major problem relates to the number of inclusions, possibly formed on a wide range of P-T conditions, having also suffered, in most cases, extensive changes after initial trapping. The

  13. Charged fluids with symmetries

    Indian Academy of Sciences (India)

    metric tensor field and generate constants of the motion along null geodesics for massless particles. Conformal symmetries arise in various physical applications. The existence of conformal symmetries in relativistic cosmological models, with restrictions on the matter content and fluid four-velocity, have been extensively ...

  14. FY-09 Report: Experimental Validation of Stratified Flow Phenomena, Graphite Oxidation, and Mitigation Strategies of Air Ingress Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Chang H. Oh; Eung S. Kim

    2009-12-01

    The Idaho National Laboratory (INL), under the auspices of the U.S. Department of Energy, is performing research and development that focuses on key phenomena important during potential scenarios that may occur in the Next Generation Nuclear Plant (NGNP)/Gen-IV very high temperature reactor (VHTR). Phenomena Identification and Ranking Studies to date have identified that an air ingress event following on the heels of a VHTR depressurization is a very important incident. Consequently, the development of advanced air ingress-related models and verification and validation data are a very high priority for the NGNP Project. Following a loss of coolant and system depressurization incident, air will enter the core through the break, leading to oxidation of the in-core graphite structure and fuel. If this accident occurs, the oxidation will accelerate heat-up of the bottom reflector and the reactor core and will eventually cause the release of fission products. The potential collapse of the core bottom structures causing the release of CO and fission products is one of the concerns. Therefore, experimental validation with the analytical model and computational fluid dynamic (CFD) model developed in this study is very important. Estimating the proper safety margin will require experimental data and tools, including accurate multidimensional thermal-hydraulic and reactor physics models, a burn-off model, and a fracture model. It will also require effective strategies to mitigate the effects of oxidation. The results from this research will provide crucial inputs to the INL NGNP/VHTR Methods Research and Development project. The second year of this three-year project (FY-08 to FY-10) was focused on (a) the analytical, CFD, and experimental study of air ingress caused by density-driven, stratified, countercurrent flow; (b) advanced graphite oxidation experiments and modeling; (c) experimental study of burn-off in the core bottom structures, (d) implementation of advanced

  15. Large-Eddy Simulation of Very-Large-Scale Motions in the Neutrally Stratified Atmospheric Boundary Layer

    Science.gov (United States)

    Fang, Jiannong; Porté-Agel, Fernando

    2015-06-01

    Large-eddy simulation is used to investigate very-large-scale motions (VLSMs) in the neutrally stratified atmospheric boundary layer at a very high friction Reynolds number, . The vertical height of the computational domain is m, which corresponds to the thickness of the boundary layer. In order to make sure that the largest flow structures are properly resolved, the horizontal domain size is chosen to be and , which is much larger than the standard domain size, especially in the streamwise direction (i.e., the direction of elongation of the flow structures). It is shown that the contributions to the resolved turbulent kinetic energy and the resolved shear stress from streamwise wavelengths larger than are up to 27 and 31 % respectively. Therefore, the large computational domain adopted here is essential for the purpose of investigating VLSMs. The spatially coherent structures associated with VLSMs are characterized through flow visualization and statistical analysis. The instantaneous velocity fields in horizontal planes give evidence of streamwise-elongated flow structures of low-speed fluid with negative fluctuation of the streamwise velocity component, and which are flanked on either side by similarly elongated high-speed structures. The pre-multiplied power spectra and two-point correlations indicate that the scales of these streak-like structures are very large, up to in the streamwise direction and in the spanwise direction. These features are similar to those found in the logarithmic and outer regions of laboratory-scale boundary layers by direct numerical simulation and experiments conducted at low to moderate Reynolds numbers. The three-dimensional correlation map and conditional average of the three components of velocity further indicate that the low-speed and high-speed regions possess the same elongated ellipsoid-like structure, which is inclined upward along the streamwise direction, and they are accompanied by counter-rotating roll modes in the

  16. Prognostic implications of fluid balance in ST elevation myocardial infarction complicated by cardiogenic shock.

    Science.gov (United States)

    Arbel, Yaron; Mass, Ronen; Ziv-Baran, Tomer; Khoury, Shafik; Margolis, Gilad; Sadeh, Ben; Flint, Nir; Ben-Shoshan, Jeremy; Finn, Talya; Keren, Gad; Shacham, Yacov

    2017-08-01

    Positive fluid balance has been associated with adverse outcomes in patients admitted to general intensive care units. We analysed the relationship between a positive fluid balance and its persistence over time in terms of in-hospital outcomes among ST elevation myocardial infarction (STEMI) patients complicated by cardiogenic shock. We retrospectively studied fluid intake and output for 96 hours following hospital admission in 48 consecutive adult patients with STEMI complicated by cardiogenic shock, all undergoing primary angioplasty. Daily and accumulated fluid balance was registered at up to 96 hours following admission. The cohort was stratified into two groups based on the presence or absence of positive fluid balance on day 4. Patients' records were assessed for in-hospital adverse outcomes, as well as 30-day all-cause mortality. A positive fluid balance was present in 19/48 patients (40%). Patients with positive fluid balance were older and more likely to be treated by intra-aortic balloon counter-pulsation and antibiotics. These patients were more likely to develop acute kidney injury and to need new intubation and were less likely to have renal function recovery as well as successful weaning from mechanical ventilation ( p balance had higher 30-day mortality (68% vs. 10%; p balance, the adjusted risk for 30-day mortality increased by 24% (hazard ratio: 1.24, 95% confidence interval: 1.07-1.42; p = 0.003). A positive fluid balance was strongly associated with higher 30-day mortality in STEMI complicated by cardiogenic shock.

  17. Evaluation of a Stratified National Breast Screening Program in the United Kingdom: An Early Model-Based Cost-Effectiveness Analysis

    NARCIS (Netherlands)

    Gray, E.; Donten, A.; Karssemeijer, N.; Gils, C. van; Evans, D.G.; Astley, S.; Payne, K.

    2017-01-01

    OBJECTIVES: To identify the incremental costs and consequences of stratified national breast screening programs (stratified NBSPs) and drivers of relative cost-effectiveness. METHODS: A decision-analytic model (discrete event simulation) was conceptualized to represent four stratified NBSPs (risk 1,

  18. Evaluation of a Stratified National Breast Screening Program in the United Kingdom : An Early Model-Based Cost-Effectiveness Analysis

    NARCIS (Netherlands)

    Gray, Ewan; Donten, Anna; Karssemeijer, Nico; van Gils, Carla; Evans, D. Gareth R.; Astley, Sue; Payne, Katherine

    Objectives: To identify the incremental costs and consequences of stratified national breast screening programs (stratified NBSPs) and drivers of relative cost-effectiveness. Methods: A decision-analytic model (discrete event simulation) was conceptualized to represent four stratified NBSPs (risk 1,

  19. Effects of recombinant plasmid pEgr-p53 transfected stably in combination with X-irradiation on cell cycle progression and proliferation in human SKOV-3 tumor cells in vitro

    International Nuclear Information System (INIS)

    Dong Lihua; Liu Feng; Li Yanbo; Fu Shibo; Gong Shouliang

    2008-01-01

    Objective: To investigate the effect of recombinant plasmid pEgr-hp53 transfected stably in combination with X-ray irradiation on the cell cycle progression and the proliferation in human SKOV-3 tumor cells. Methods: pEgr-hp53 and pcDNA3.1 packaged with liposome were stably transfected into SKOV-3 cells in vitro. SKOV-3-hp53 and SKOV-3-vect were irradiated with 0, 0.5, 2.0 and 5.0 Gy X-rays, respectively, i.e. 8 experimental groups. The SKOV-3 cell proliferation and the cell cycle progression were measured with flow cytometry and cell growth curve, respectively. Results: Compared with 0 Gy group, the cell counts in SKOV-3- hp53 plus different doses of irradiation groups 2 d after irradiation decreased significantly (P 0 /G 1 cells increased significantly (P 2 /M cells decreased in varying degrees. The cell counts in SKOV-3-hp53 plus irradiation group were significantly lower than those in corresponding SKOV-3-vect plus irradiation group, the cell counts 4-8 d after irradiation with 0.5 Gy, 2 d after 2.0 Gy irradiation and 6 d after 5.0 Gy irradiation decreased significantly (P 0 /G 1 cells increased significantly (P 2 /M cells decreased significantly (P 1 arrest in SKOV-3 cells and inhibits the cell proliferation. Ionizing radiation can activate early growth response-1 (Egr-1) gene promoter and increase the expression of p53 gene, and enhance the inhibition of tumor cell growth. (authors)

  20. Editorial Special Issue on Fluid Mechanics and Fluid Power (FMFP ...

    Indian Academy of Sciences (India)

    This special issue of Sadhana contains selected papers from two conferences related to fluid mechanics held in India recently, Fluid Mechanics and Fluid Power conference at NIT, Hamirpur, and an International Union of Theoretical and Applied Mechanics (IUTAM) symposium held at. Jawaharlal Nehru Centre for ...

  1. R3 fluids

    Directory of Open Access Journals (Sweden)

    Caimmi R.

    2007-01-01

    Full Text Available The current paper is aimed at getting more insight on three main points concerning large-scale astrophysical systems, namely: (i formulation of tensor virial equations from the standpoint of analytical mechanics; (ii investigation on the role of systematic and random motions with respect to virial equilibrium configurations; (iii determination of extent to which systematic and random motions are equivalent in flattening or elongating the shape of a mass distribution. The tensor virial equations are formulated regardless of the nature of the system and its constituents, by generalizing and extending a procedure used for the scalar virial equations in presence of discrete subunits (Landau and Lifchitz 1966. In particular, the self potential-energy tensor is shown to be symmetric with respect to the exchange of the indices, (Epotpq = (Epotqp. Then the results are extended to continuous mass distributions. The role of systematic and random motions in collisionless, ideal, self-gravitating fluids is analysed in detail including radial and tangential velocity dispersion on the equatorial plane, and the related mean angular velocity, Ω, is conceived as a figure rotation. R3 fluids are defined as ideal, self-gravitating fluids in virial equilibrium, with systematic rotation around a principal axis of inertia, taken to be x3. The related virial equations are written in terms of the moment of inertia tensor, Ipq, the self potential-energy tensor, (Epotpq, and the generalized anisotropy tensor, ζpq (Caimmi and Marmo 2005, Caimmi 2006a. Additional effort is devoted to the investigation of the properties of axisymmetric and triaxial configurations. A unified theory of systematic and random motions is developed for R3 fluids, taking into consideration imaginary rotation (Caimmi 1996b, 2006a, and a number of theorems previously stated for homeoidally striated Jacobi ellipsoids (Caimmi 2006a are extended to the more general case of R3 fluids. The effect of

  2. Microgravity Fluids for Biology, Workshop

    Science.gov (United States)

    Griffin, DeVon; Kohl, Fred; Massa, Gioia D.; Motil, Brian; Parsons-Wingerter, Patricia; Quincy, Charles; Sato, Kevin; Singh, Bhim; Smith, Jeffrey D.; Wheeler, Raymond M.

    2013-01-01

    Microgravity Fluids for Biology represents an intersection of biology and fluid physics that present exciting research challenges to the Space Life and Physical Sciences Division. Solving and managing the transport processes and fluid mechanics in physiological and biological systems and processes are essential for future space exploration and colonization of space by humans. Adequate understanding of the underlying fluid physics and transport mechanisms will provide new, necessary insights and technologies for analyzing and designing biological systems critical to NASAs mission. To enable this mission, the fluid physics discipline needs to work to enhance the understanding of the influence of gravity on the scales and types of fluids (i.e., non-Newtonian) important to biology and life sciences. In turn, biomimetic, bio-inspired and synthetic biology applications based on physiology and biology can enrich the fluid mechanics and transport phenomena capabilities of the microgravity fluid physics community.

  3. Handbook of hydraulic fluid technology

    CERN Document Server

    Totten, George E

    2011-01-01

    ""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

  4. Recording fluid currents by holography

    Science.gov (United States)

    Heflinger, L. O.; Wuerker, R. F.

    1980-01-01

    Convection in fluids can be studied with aid of holographic apparatus that reveals three-dimensional motion of liquid. Apparatus eliminates images of fixed particles such as dust on windows and lenses, which might mask behavior of moving fluid particles. Holographic apparatus was developed for experiments on fluid convection cells under zero gravity. Principle is adaptable to study of fluid processes-for example, electrochemical plating and combustion in automotive engines.

  5. Oscillating fluid power generator

    Science.gov (United States)

    Morris, David C

    2014-02-25

    A system and method for harvesting the kinetic energy of a fluid flow for power generation with a vertically oriented, aerodynamic wing structure comprising one or more airfoil elements pivotably attached to a mast. When activated by the moving fluid stream, the wing structure oscillates back and forth, generating lift first in one direction then in the opposite direction. This oscillating movement is converted to unidirectional rotational movement in order to provide motive power to an electricity generator. Unlike other oscillating devices, this device is designed to harvest the maximum aerodynamic lift forces available for a given oscillation cycle. Because the system is not subjected to the same intense forces and stresses as turbine systems, it can be constructed less expensively, reducing the cost of electricity generation. The system can be grouped in more compact clusters, be less evident in the landscape, and present reduced risk to avian species.

  6. COUPLED CHEMOTAXIS FLUID MODEL

    KAUST Repository

    LORZ, ALEXANDER

    2010-06-01

    We consider a model system for the collective behavior of oxygen-driven swimming bacteria in an aquatic fluid. In certain parameter regimes, such suspensions of bacteria feature large-scale convection patterns as a result of the hydrodynamic interaction between bacteria. The presented model consist of a parabolicparabolic chemotaxis system for the oxygen concentration and the bacteria density coupled to an incompressible Stokes equation for the fluid driven by a gravitational force of the heavier bacteria. We show local existence of weak solutions in a bounded domain in d, d = 2, 3 with no-flux boundary condition and in 2 in the case of inhomogeneous Dirichlet conditions for the oxygen. © 2010 World Scientific Publishing Company.

  7. Fluid dynamics an introduction

    CERN Document Server

    Rieutord, Michel

    2015-01-01

    This book is dedicated to readers who want to learn fluid dynamics from the beginning. It assumes a basic level of mathematics knowledge that would correspond to that of most second-year undergraduate physics students and examines fluid dynamics from a physicist’s perspective. As such, the examples used primarily come from our environment on Earth and, where possible, from astrophysics. The text is arranged in a progressive and educational format, aimed at leading readers from the simplest basics to more complex matters like turbulence and magnetohydrodynamics. Exercises at the end of each chapter help readers to test their understanding of the subject (solutions are provided at the end of the book), and a special chapter is devoted to introducing selected aspects of mathematics that beginners may not be familiar with, so as to make the book self-contained.

  8. Electrorheologic fluids; Fluidos electroreologicos

    Energy Technology Data Exchange (ETDEWEB)

    Rejon G, Leonardo; Lopez G, Francisco; Montoya T, Gerardo [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Manero B, Octavio [Instituto de Investigaciones en Materiales, UNAM.(Mexico)

    2003-07-01

    The present article has as an objective to offer a review of the research work made in the Instituto de Investigaciones Electricas (IIE) on the study of the electrorheologic fluids whose flow properties can abruptly change in the presence of an electric field when this is induced by a direct current. The electrorheologic fluids have their main application in the manufacture of self-controlling damping systems. [Spanish] El presente articulo tiene por objetivo ofrecer una resena de los trabajos de investigacion realizados en el Instituto de Investigaciones Electricas (IIE) sobre el estudio de los fluidos electroreologicos cuyas propiedades de flujo pueden cambiar abruptamente en presencia de un campo electrico cuando este es inducido por una corriente directa. Los fluidos electroreologicos tienen su principal aplicacion en la fabricacion de sistemas de amortiguamiento autocontrolables.

  9. Active chiral fluids.

    Science.gov (United States)

    Fürthauer, S; Strempel, M; Grill, S W; Jülicher, F

    2012-09-01

    Active processes in biological systems often exhibit chiral asymmetries. Examples are the chirality of cytoskeletal filaments which interact with motor proteins, the chirality of the beat of cilia and flagella as well as the helical trajectories of many biological microswimmers. Here, we derive constitutive material equations for active fluids which account for the effects of active chiral processes. We identify active contributions to the antisymmetric part of the stress as well as active angular momentum fluxes. We discuss four types of elementary chiral motors and their effects on a surrounding fluid. We show that large-scale chiral flows can result from the collective behavior of such motors even in cases where isolated motors do not create a hydrodynamic far field.

  10. A mechanically enhanced hybrid nano-stratified barrier with a defect suppression mechanism for highly reliable flexible OLEDs.

    Science.gov (United States)

    Jeong, Eun Gyo; Kwon, Seonil; Han, Jun Hee; Im, Hyeon-Gyun; Bae, Byeong-Soo; Choi, Kyung Cheol

    2017-05-18

    Understanding the mechanical behaviors of encapsulation barriers under bending stress is important when fabricating flexible organic light-emitting diodes (FOLEDs). The enhanced mechanical characteristics of a nano-stratified barrier were analyzed based on a defect suppression mechanism, and then experimentally demonstrated. Following the Griffith model, naturally-occurring cracks, which were caused by Zn etching at the interface of the nano-stratified structure, can curb the propagation of defects. Cross-section images after bending tests provided remarkable evidence to support the existence of a defect suppression mechanism. Many visible cracks were found in a single Al 2 O 3 layer, but not in the nano-stratified structure, due to the mechanism. The nano-stratified structure also enhanced the barrier's physical properties by changing the crystalline phase of ZnO. In addition, experimental results demonstrated the effect of the mechanism in various ways. The nano-stratified barrier maintained a low water vapor transmission rate after 1000 iterations of a 1 cm bending radius test. Using this mechanically enhanced hybrid nano-stratified barrier, FOLEDs were successfully encapsulated without losing mechanical or electrical performance. Finally, comparative lifetime measurements were conducted to determine reliability. After 2000 hours of constant current driving and 1000 iterations with a 1 cm bending radius, the FOLEDs retained 52.37% of their initial luminance, which is comparable to glass-lid encapsulation, with 55.96% retention. Herein, we report a mechanically enhanced encapsulation technology for FOLEDs using a nano-stratified structure with a defect suppression mechanism.

  11. Magnetorheological Fluids and Elastomers

    Science.gov (United States)

    Ginder, John

    2002-03-01

    Magnetorheological (MR) materials possess mechanical or rheological properties that can be controlled by magnetic fields. MR fluids, perhaps the prototypical MR materials, comprise magnetically soft particles dispersed in polar or nonpolar liquids. The particles in these fluids align to form chains or more complex structures when a magnetic field is applied; these structures resist mechanical deformation, reversibly transforming the fluid into a weak viscoelastic solid. Other MR materials include magnetic powders, in which the magnetic particles are dispersed in air and which also become weak solids in an applied field. MR elastomers, a third class of these materials, contain magnetizable particles dispersed in elastomeric solids. These elastomers are magnetostrictive, possessing substantial field-induced modulus increases and elongations. The fascinating behavior of these materials, together with their many potential uses in the automobile and elsewhere, has motivated considerable scientific and technological progress over the last decade. While magnetic powders have been used in industrial applications for decades, the first components using MR fluids were marketed in the mid-1990s, and the first commercial automotive applications are imminent. In this presentation, I will survey the physical properties of MR materials and sketch our understanding of their origins, paying particular attention to the central role of field-induced interparticle magnetic forces and the nature and dynamics of the resulting microstructure. I will describe some possible automotive applications based on these materials, focusing on the material properties and component performance that is required. Finally, I will identify some of the open scientific and technical issues in this growing field.

  12. Fluid circulation control device

    International Nuclear Information System (INIS)

    Benard, Henri; Henocque, Jean.

    1982-01-01

    Horizontal fluid circulation control device, of the type having a pivoting flap. This device is intended for being fitted in the pipes of hydraulic installation, particularly in a bleed and venting system of a nuclear power station shifting radioactive or contaminated liquids. The characteristic of this device is the cut-out at the top of the flap to allow the air contained in the pipes to flow freely [fr

  13. Measuring fluid pressure

    International Nuclear Information System (INIS)

    Lee, A.S.

    1978-01-01

    A method and apparatus are described for measuring the pressure of a fluid having characteristics that make it unsuitable for connection directly to a pressure gauge. The method is particularly suitable for the periodic measurement of the pressure of a supply of liquid Na to Na-lubricated bearings of pumps for pumping Na from a reservoir to the bearing via a filter, the reservoir being contained in a closed vessel containing an inert blanket gas, such as Ar, above the Na. (UK)

  14. The mixing of fluids

    International Nuclear Information System (INIS)

    Ottino, J.M.

    1989-01-01

    What do the eruption of Krakatau, the manufacture of puff pastry and the brightness of stars have in common? Each involves some aspect of mixing. Mixing also plays a critical role in modern technology. Chemical engineers rely on mixing to ensure that substances react properly, to produce polymer blends that exhibit unique properties and to disperse drag-reducing agents in pipelines. Yet in spite of its of its ubiquity in nature and industry, mixing is only imperfectly under-stood. Indeed, investigators cannot even settle on a common terminology: mixing is often referred to as stirring by oceanographers and geophysicists, as blending by polymer engineers and as agitation by process engineers. Regardless of what the process is called, there is little doubt that it is exceedingly complex and is found in a great variety of systems. In constructing a theory of fluid mixing, for example, one has to take into account fluids that can be miscible or partially miscible and reactive or inert, and flows that are slow and orderly or very fast and turbulent. It is therefore not surprising that no single theory can explain all aspect of mixing in fluids and that straightforward computations usually fail to capture all the important details. Still, both physical experiments and computer simulations can provide insight into the mixing process. Over the past several years the authors and his colleague have taken both approaches in an effort to increase understanding of various aspect of the process-particularly of mixing involving slow flows and viscous fluids such as oils

  15. Redox stratified biofilms to support completely autotrophic nitrogen removal: Principles and results

    DEFF Research Database (Denmark)

    Pellicer i Nàcher, Carles; Smets, Barth F.

    liquid. If operated properly, MABRs yield compact and homogeneous redox-stratified biofilms capable of hosting side-by-side aerobic and anaerobic microbial communities. We have recently demonstrated that completely autotrophic nitrogen removal is feasible in MABRs at nitrogen removal rates as high as 5...... bacteria in compact reaction zones about 100 m thick separated by an intermediate zone with low or null metabolic activity. Both identified microbial communities showed a very low diversity and were dominated by halophilic and halotolerant Nitrosomonas sp. and Candidatus Brocadia anammoxidans....... The continuous and sustained inoculation of metabolically active anaerobic oxidizing bacteria from a biofilm reactor placed in the recirculation line of our MABRs showed to shorten considerably the onset of autotrophic nitrogen removal. However, the main hurdle keeping MABRs from attaining high removal...

  16. Acoustic and Slow Sausage Oscillations in the Stratified Solar Photosphere: Hinode Observations and Phase Relationships

    Science.gov (United States)

    Tsap, Y. T.; Stepanov, A. V.; Kopylova, Y. G.

    2016-11-01

    Based on the linearized magnetohydrodynamic (MHD) equations within the framework of the thin flux tube approximation, the phase relationships between the disturbed quantities of evanescent acoustic and slow sausage MHD modes excited in the adiabatically stratified solar atmosphere are considered. It has been shown that the sign of the phase differences (equal to ±π/2) between the velocity and other disturbed quantities such as pressure, density, magnetic field, and temperature, depends on the wave frequency ω. The obtained phase relationships agree well with SOT/ Hinode observations obtained by Fujimura and Tsuneta ( Astrophys. J. 702, 1443, 2009) when ω≈ωc, where ωc is the cutoff frequency. The role of various modes excited in the solar atmosphere in the light of the chromospheric and coronal heating problems are discussed.

  17. Management of kidney cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012.

    Science.gov (United States)

    Chiong, Edmund; Tay, Miah Hiang; Tan, Min Han; Kumar, Santosh; Sim, Hong Gee; Teh, Bin Tean; Umbas, Rainy; Chau, Noan Minh

    2012-11-01

    Treatment of renal-cell carcinoma has progressed over the past decade, in terms of surgical and systemic therapy. Current treatment guidelines are based on clinical evidence, but do not take into account resource limitations among different countries. These limitations, which include financial and logistical challenges and lack of skilled health-care professionals, have the greatest effect in low-income countries. This consolidated statement gives treatment recommendations for renal-cell carcinoma that are based on clinical evidence and stratified according to extent of resource availability. The statement was formulated by a panel of urologists, medical oncologists, and clinical oncologists from Asian countries, at a consensus session on kidney cancer that was held as part of the 2012 Asian Oncology Summit in Singapore. Resource levels are defined according to a four-tier system (basic, limited, enhanced, and maximum), and treatment recommendations are specified based on availability of financial, skill, and logistical resources. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. An experimental investigation of stratified two-phase pipe flow at small inclinations

    Energy Technology Data Exchange (ETDEWEB)

    Espedal, Mikal

    1998-12-31

    The prediction of stratified flow is important for several industrial applications. Stratified flow experiments were carefully performed in order to investigate the performance of a typical model which uses wall friction factors based on single phase pipe flow as described above. The test facility has a 18.5 m long and 60 mm i.d. (L/D=300) acrylic test section which can be inclined between -10 {sup o} and +10 {sup o}. The liquid holdup was measured by using fast closing valves and the pressure gradients by using three differential pressure transducers. Interfacial waves were measured by thin wire conductance probes mounted in a plane perpendicular to the main flow. The experiments were performed using water and air at atmospheric pressure. The selected test section inclinations were between -3 {sup o} and +0.5 {sup o} to the horizontal plane. A large number of experiments were performed for different combinations of air and water flow rates and the rates were limited to avoid slug flow and stratified flow with liquid droplets. The pressure gradient and the liquid holdup were measured. In addition the wave probes were used to find the wave heights and the wave power spectra. The results show that the predicted pressure gradient using the standard models is approximately 30% lower than the measured value when large amplitude waves are present. When the flow is driven by the interfacial force the test section inclination has minor influence on the deviation between predicted and measured pressure gradients. Similar trends are apparent in data from the literature, although they seem to have gone unnoticed. For several data sets large spread in the predictions are observed when the model described above was used. Gas wall shear stress experiments indicate that the main cause of the deviation between measured and predicted pressure gradient and holdup resides in the modelling of the liquid wall friction term. Measurements of the liquid wall shear stress distribution

  19. Piezoelectricity induced defect modes for shear waves in a periodically stratified supperlattice

    Science.gov (United States)

    Piliposyan, Davit

    2018-01-01

    Properties of shear waves in a piezoelectric stratified periodic structure with a defect layer are studied for a superlattice with identical piezoelectric materials in a unit cell. Due to the electro-mechanical coupling in piezoelectric materials the structure exhibits defect modes in the superlattice with full transmission peaks both for full contact and electrically shorted interfaces. The results show an existence of one or two transmission peaks depending on the interfacial conditions. In the long wavelength region where coupling between electro-magnetic and elastic waves creates frequency band gaps the defect layer introduces one or two defect modes transmitting both electro-magnetic and elastic energies. Other parameters affecting the defect modes are the thickness of the defect layer, differences in refractive indexes and the magnitude of the angle of the incident wave. The results of the paper may be useful in the design of narrow band filters or multi-channel piezoelectric filters.

  20. Experimental Investigation of Performance and Emissions of a Stratified Charge CNG Direct Injection Engine with Turbocharger

    Directory of Open Access Journals (Sweden)

    Amiruddin Hilmi

    2017-01-01

    Full Text Available This paper presents the results from 1.6 litre, 4 cylinders stratified charge compressed natural gas (CNG direct injection engine with boosting device. A turbocharger with compressor trim of 40 was used to increase engine output. The engine was tested at wide open throttle (WOT and speed ranging from 1000 to 5000 rpm. Engine performance and emissions data were recorded under steady state condition. Results show turbocharged CNG engine produced an average of 26% increment in brake power and 24% additional maximum brake torque as compared with natural aspirated (NA CNG engine. Turbocharged CNG engine improved brake specific fuel consumption (BSFC and yielded higher fuel conversion efficiency (FCE. Relatively turbocharged CNG engine showed lower emission of hydrocarbon (HC and carbon monoxide (CO throughout tested engine speed. Conversely, the carbon dioxide (CO2 and nitrogen oxide (NOx emission produced were slightly higher compared with NA CNG engine.

  1. Upscaling of Two-Phase Immiscible Flows in Communicating Stratified Reservoirs

    DEFF Research Database (Denmark)

    Zhang, Xuan; Shapiro, Alexander; Stenby, Erling Halfdan

    2011-01-01

    A semi-analytical method for upscaling two-phase immiscible flows in heterogeneous porous media is described. This method is developed for stratified reservoirs with perfect communication between layers (the case of vertical equilibrium), in a viscous dominant regime, where the effects of capillary....... They are solved numerically, based on an upstream finite difference algorithm. Self-similarity of the solution makes it possible to compute pseudofractional flow functions depending on the average saturation. The computer partial differential equation solver COMSOL is used for comparison of the complete 2D...... solutions with averaged 1D simulations. Cases of both discrete and continuous (log-normal) permeability distribution are studied. Generally, saturation profiles of the 1D model are only slightly different from the 2D simulation results. Recovery curves and fractional flow curves fit well. Calculations show...

  2. Numerical study on interaction of local air cooler with stratified hydrogen cloud in a large vessel

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Z. [Atomic Energy of Canada Limited, Chalk River Laboratories, ON K0J 1J0 (Canada); Andreani, M. [Laboratory for Thermal-Hydraulics, Paul Scherrer Institut, 5232 Villigen (Switzerland)

    2012-07-01

    Within the framework of the ERCOSAM project, planning calculations are performed to examine sensitivity parameters that can affect the break-up (erosion) of a helium layer by mitigation devices (i.e., cooler, spray, or Passive Autocatalytic Recombiner - PAR). This paper reports the GOTHIC analysis results for the cooler tests to be performed in the PANDA facility. The cooler elevation and geometry, helium layer thickness, steam distribution in the vessel, and the vessel geometry (inter-connected multi-compartments versus a single volume) on the erosion process as well as the cooling capacity are studied. This analysis is valuable because only a limited number of conditions will be examined in the planned experiments. The study provides a useful understanding of the interaction of a cooler with a stratified atmosphere. (authors)

  3. First detection of mycobacteria in African rodents and insectivores, using stratified pool screening

    DEFF Research Database (Denmark)

    Durnez, L.; Eddyani, M.; Mgode, G. F.

    2007-01-01

    With the rising number of patients with human immunodeficiency virus (HIV)/AIDS in developing countries, the control of mycobacteria is of growing importance. Previous studies have shown that rodents and insectivores are carriers of mycobacteria. However, it is not clear how widespread mycobacteria...... spp.) were isolated from C. gambianus, Mastomys natalensis, and C. hirta. This study is the first to report findings of mycobacteria in African rodents and insectivores and the first in mycobacterial ecology to estimate the prevalence of mycobacteria after stratified pool screening. The fact...... that small mammals in urban areas carry more mycobacteria than those in the fields and that potentially pathogenic mycobacteria were isolated identifies a risk for other animals and humans, especially HIV/AIDS patients, that have a weakened immune system. ...

  4. Expression of GLUT1 in stratified squamous epithelia and oral carcinoma from humans and rats

    DEFF Research Database (Denmark)

    Voldstedlund, M; Dabelsteen, Erik

    1997-01-01

    mucosa from rat and man, and a human oral carcinoma by indirect immunofluorescence microscopy. The results showed that GLUT1 was expressed in the basal and parabasal layers of the different stratified squamous epithelia, with some variations between keratinized and non-keratinized subtypes. GLUT1...... was also expressed in ductal- and myoepithelial cells of minor salivary glands and perineural sheath located in the lamina propra, and furthermore in the cells of an oral carcinoma. GLUT4 was not expressed in any of the tissues examined. This distribution of GLUT1 does not fit with the idea of GLUT1......Most cells express facilitative glucose transporters. Four isoforms (GLUT1-4) transporting D-glucose across the plasma membrane show a specific tissue distribution, which is the basis for tissue-specific patterns in glucose metabolism. GLUT1 is expressed at high levels in tissue barriers...

  5. 'Stratified Contraception': Emergency Contraceptive Pills and Women's Differential Experiences in Contemporary India.

    Science.gov (United States)

    Sheoran, Nayantara

    2015-01-01

    Available without prescriptions in India since 2005, emergency contraceptive pills (ECPs) and their advertisements have provided women with increased contraceptive options and a vocabulary to talk about their reproductive lives. I draw on long-term fieldwork with women in urban India about ECPs, demonstrating a new form of 'stratified contraception' enabled by these pills and their advertisements. I posit that there are within India spaces that replicate the luxuries and privileges of the global North. These material conditions, I suggest, are replicated when it comes to contraception as there are hubs of women consumers of contraception and contraceptive advertising that participate in an 'imagined cosmopolitanism' within the global South in close proximity to 'contraceptive ghettos.' Moving beyond simplistic binaries, I outline three major stratifications along which women experience this medical technology and outline the implications for women and their contraceptive choices when notions of northern privilege exist in the 'South.'

  6. A Case Study on Stratified Settlement and Rebound Characteristics due to Dewatering in Shanghai Subway Station

    Directory of Open Access Journals (Sweden)

    Jianxiu Wang

    2013-01-01

    Full Text Available Based on the Yishan Metro Station Project of Shanghai Metro Line number 9, a centrifugal model test was conducted to investigate the behavior of stratified settlement and rebound (SSR of Shanghai soft clay caused by dewatering in deep subway station pit. The soil model was composed of three layers, and the dewatering process was simulated by self-invention of decompressing devise. The results indicate that SSR occurs when the decompression was carried out, and only negative rebound was found in sandy clay, but both positive and negative rebound occurred in the silty clay, and the absolute value of rebound in sandy clay was larger than in silty clay, and the mechanism of SSR was discussed with mechanical sandwich model, and it was found that the load and cohesive force of different soils was the main source of different responses when decompressed.

  7. Regional variations of cell surface carbohydrates in human oral stratified epithelium

    DEFF Research Database (Denmark)

    Vedtofte, P; Dabelsteen, Erik; Hakomori, S

    1984-01-01

    The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns...... such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized......-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal and alveolar epithelium (non-keratinized) which differed considerably from that seen in palatal and gingival epithelium (ortho- and parakeratinized). The expression of blood group antigens A or B and the precursor...

  8. Stable evaluation of Green's functions in cylindrically stratified regions with uniaxial anisotropic layers

    Energy Technology Data Exchange (ETDEWEB)

    Moon, H., E-mail: haksu.moon@gmail.com [ElectroScience Laboratory, The Ohio State University, Columbus, OH 43212 (United States); Donderici, B., E-mail: burkay.donderici@halliburton.com [Sensor Physics & Technology, Halliburton Energy Services, Houston, TX 77032 (United States); Teixeira, F.L., E-mail: teixeira@ece.osu.edu [ElectroScience Laboratory, The Ohio State University, Columbus, OH 43212 (United States)

    2016-11-15

    We present a robust algorithm for the computation of electromagnetic fields radiated by point sources (Hertzian dipoles) in cylindrically stratified media where each layer may exhibit material properties (permittivity, permeability, and conductivity) with uniaxial anisotropy. Analytical expressions are obtained based on the spectral representation of the tensor Green's function based on cylindrical Bessel and Hankel eigenfunctions, and extended for layered uniaxial media. Due to the poor scaling of these eigenfunctions for extreme arguments and/or orders, direct numerical evaluation of such expressions can produce numerical instability, i.e., underflow, overflow, and/or round-off errors under finite precision arithmetic. To circumvent these problems, we develop a numerically stable formulation through suitable rescaling of various expressions involved in the computational chain, to yield a robust algorithm for all parameter ranges. Numerical results are presented to illustrate the robustness of the formulation including cases of practical interest.

  9. Stable evaluation of Green's functions in cylindrically stratified regions with uniaxial anisotropic layers

    Science.gov (United States)

    Moon, H.; Donderici, B.; Teixeira, F. L.

    2016-11-01

    We present a robust algorithm for the computation of electromagnetic fields radiated by point sources (Hertzian dipoles) in cylindrically stratified media where each layer may exhibit material properties (permittivity, permeability, and conductivity) with uniaxial anisotropy. Analytical expressions are obtained based on the spectral representation of the tensor Green's function based on cylindrical Bessel and Hankel eigenfunctions, and extended for layered uniaxial media. Due to the poor scaling of these eigenfunctions for extreme arguments and/or orders, direct numerical evaluation of such expressions can produce numerical instability, i.e., underflow, overflow, and/or round-off errors under finite precision arithmetic. To circumvent these problems, we develop a numerically stable formulation through suitable rescaling of various expressions involved in the computational chain, to yield a robust algorithm for all parameter ranges. Numerical results are presented to illustrate the robustness of the formulation including cases of practical interest.

  10. Topography evolution in sputtered stratified media and in spatio-time variable ion flux conditions

    Energy Technology Data Exchange (ETDEWEB)

    Carter, G.; Nobes, M.J.; Lewis, G.W.; Cox, J.

    Earlier theoretical studies on the development of topography on solids sputtered by spatially uniform and spatially non-uniform ion fluxes are extended to a general treatment including spatially non-uniform (e.g. stratified) solids and time varying ion fluxes. It is shown that the former case is relevant to the sputter erosion of, for example, polycrystalline media, dislocated solids and surface contaminant protection situations. Predictions of feature development in these three cases is shown to correspond very well with experimental studies, and offers convincing explanation of the different etch pit elaboration processes, associated with dislocations, depending upon incident ion beam and rotated target situations and the relevance of the theory to practical situations of (1) substrate thinning and polishing and (2) controlled surface contour evolution are outlined. Some simulation studies with sand blasting, which is, in many ways, a macroscopic analogue of ion bombardment sputter erosion are presented also.

  11. Stratifying Tropical Fires by Land Cover: Insights into Amazonian Fires, Aerosol Loading, and Regional Deforestation

    Science.gov (United States)

    TenHoeve, J. E.; Remer, L. A.; Jacobson, M. Z.

    2010-01-01

    This study analyzes changes in the number of fires detected on forest, grass, and transition lands during the 2002-2009 biomass burning seasons using fire detection data and co-located land cover classifications from the Moderate Resolution Imaging Spectroradiometer (MODIS). We find that the total number of detected fires correlates well with MODIS mean aerosol optical depth (AOD) from year to year, in accord with other studies. However, we also show that the ratio of forest to savanna fires varies substantially from year to year. Forest fires have trended downward, on average, since the beginning of 2006 despite a modest increase in 2007. Our study suggests that high particulate matter loading detected in 2007 was likely due to a large number of savanna/agricultural fires that year. Finally, we illustrate that the correlation between annual Brazilian deforestation estimates and MODIS fires is considerably higher when fires are stratified by MODIS-derived land cover classifications.

  12. Fuel-air mixing and distribution in a direct-injection stratified-charge rotary engine

    Science.gov (United States)

    Abraham, J.; Bracco, F. V.

    1989-01-01

    A three-dimensional model for flows and combustion in reciprocating and rotary engines is applied to a direct-injection stratified-charge rotary engine to identify the main parameters that control its burning rate. It is concluded that the orientation of the six sprays of the main injector with respect to the air stream is important to enhance vaporization and the production of flammable mixture. In particular, no spray should be in the wake of any other spray. It was predicted that if such a condition is respected, the indicated efficiency would increase by some 6 percent at higher loads and 2 percent at lower loads. The computations led to the design of a new injector tip that has since yielded slightly better efficiency gains than predicted.

  13. Performance of a supercharged direct-injection stratified-charge rotary combustion engine

    Science.gov (United States)

    Bartrand, Timothy A.; Willis, Edward A.

    1990-01-01

    A zero-dimensional thermodynamic performance computer model for direct-injection stratified-charge rotary combustion engines was modified and run for a single rotor supercharged engine. Operating conditions for the computer runs were a single boost pressure and a matrix of speeds, loads and engine materials. A representative engine map is presented showing the predicted range of efficient operation. After discussion of the engine map, a number of engine features are analyzed individually. These features are: heat transfer and the influence insulating materials have on engine performance and exhaust energy; intake manifold pressure oscillations and interactions with the combustion chamber; and performance losses and seal friction. Finally, code running times and convergence data are presented.

  14. Downhole Fluid Analyzer Development

    Energy Technology Data Exchange (ETDEWEB)

    Bill Turner

    2006-11-28

    A novel fiber optic downhole fluid analyzer has been developed for operation in production wells. This device will allow real-time determination of the oil, gas and water fractions of fluids from different zones in a multizone or multilateral completion environment. The device uses near infrared spectroscopy and induced fluorescence measurement to unambiguously determine the oil, water and gas concentrations at all but the highest water cuts. The only downhole components of the system are the fiber optic cable and windows. All of the active components--light sources, sensors, detection electronics and software--will be located at the surface, and will be able to operate multiple downhole probes. Laboratory testing has demonstrated that the sensor can accurately determine oil, water and gas fractions with a less than 5 percent standard error. Once installed in an intelligent completion, this sensor will give the operating company timely information about the fluids arising from various zones or multilaterals in a complex completion pattern, allowing informed decisions to be made on controlling production. The research and development tasks are discussed along with a market analysis.

  15. Geophysical fluid dynamics

    CERN Document Server

    Pedlosky, Joseph

    1979-01-01

    The content of this book is based, largely, on the core curriculum in geophys­ ical fluid dynamics which I and my colleagues in the Department of Geophysical Sciences at The University of Chicago have taught for the past decade. Our purpose in developing a core curriculum was to provide to advanced undergraduates and entering graduate students a coherent and systematic introduction to the theory of geophysical fluid dynamics. The curriculum and the outline of this book were devised to form a sequence of courses of roughly one and a half academic years (five academic quarters) in length. The goal of the sequence is to help the student rapidly advance to the point where independent study and research are practical expectations. It quickly became apparent that several topics (e. g. , some aspects of potential theory) usually thought of as forming the foundations of a fluid-dynamics curriculum were merely classical rather than essential and could be, however sadly, dispensed with for our purposes. At the same ti...

  16. Geophysical fluid dynamics

    CERN Document Server

    Pedlosky, Joseph

    1982-01-01

    The content of this book is based, largely, on the core curriculum in geophys­ ical fluid dynamics which land my colleagues in the Department of Geophysical Sciences at The University of Chicago have taught for the past decade. Our purpose in developing a core curriculum was to provide to advanced undergraduates and entering graduate students a coherent and systematic introduction to the theory of geophysical fluid dynamics. The curriculum and the outline of this book were devised to form a sequence of courses of roughly one and a half academic years (five academic quarters) in length. The goal of the sequence is to help the student rapidly advance to the point where independent study and research are practical expectations. It quickly became apparent that several topics (e. g. , some aspects of potential theory) usually thought of as forming the foundations of a fluid-dynamics curriculum were merely classical rather than essential and could be, however sadly, dispensed with for our purposes. At the same tim...

  17. Astrophysical fluid dynamics

    Science.gov (United States)

    Ogilvie, Gordon I.

    2016-06-01

    > These lecture notes and example problems are based on a course given at the University of Cambridge in Part III of the Mathematical Tripos. Fluid dynamics is involved in a very wide range of astrophysical phenomena, such as the formation and internal dynamics of stars and giant planets, the workings of jets and accretion discs around stars and black holes and the dynamics of the expanding Universe. Effects that can be important in astrophysical fluids include compressibility, self-gravitation and the dynamical influence of the magnetic field that is `frozen in' to a highly conducting plasma. The basic models introduced and applied in this course are Newtonian gas dynamics and magnetohydrodynamics (MHD) for an ideal compressible fluid. The mathematical structure of the governing equations and the associated conservation laws are explored in some detail because of their importance for both analytical and numerical methods of solution, as well as for physical interpretation. Linear and nonlinear waves, including shocks and other discontinuities, are discussed. The spherical blast wave resulting from a supernova, and involving a strong shock, is a classic problem that can be solved analytically. Steady solutions with spherical or axial symmetry reveal the physics of winds and jets from stars and discs. The linearized equations determine the oscillation modes of astrophysical bodies, as well as their stability and their response to tidal forcing.

  18. Dynamics of radiating fluids

    International Nuclear Information System (INIS)

    Mihalas, D.; Weaver, R.

    1982-01-01

    The purpose of this paper is to give an overview of the role of radiation in the transport of energy and momentum in a combined matter-radiation fluid. The transport equation for a moving radiating fluid is presented in both a fully Eulerian and a fully Lagrangian formulation, along with conservation equations describing the dynamics of the fluid. Special attention is paid to the problem of deriving equations that are mutually consistent in each frame, and between frames, to 0(v/c). A detailed analysis is made to show that in situations of broad interest, terms that are formally of 0(v/c) actually dominate the solution, demonstrating that it is essential (1) to pay scrupulous attention to the question of the frame dependence in formulating the equations, and (2) to solve the equations to 0(v/c) in quite general circumstances. These points are illustrated in the context of the nonequilibrium radiation diffusion limit, and a sketch of how the Lagrangian equations are to be solved is presented

  19. Supercritical fluids cleaning

    Energy Technology Data Exchange (ETDEWEB)

    Butner, S.; Hjeresen, D.; Silva, L.; Spall, D.; Stephenson, R.

    1991-01-01

    This paper discusses a proposed multi-party research and development program which seeks to develop supercritical fluid cleaning technology as an alternative to existing solvent cleaning applications. While SCF extraction technology has been in commercial use for several years, the use of these fluids as cleaning agents poses several new technical challenges. Problems inherent in the commercialization of SCF technology include: the cleaning efficacy and compatibility of supercritical working fluids with the parts to be cleaned must be assessed for a variety of materials and components; process parameters and equipment design Have been optimized for extractive applications and must be reconsidered for application to cleaning; and co-solvents and entrainers must be identified to facilitate the removal of polar inorganic and organic contaminants, which are often not well solvated in supercritical systems. The proposed research and development program would address these issues and lead to the development and commercialization of viable SCF-based technology for precision cleaning applications. This paper provides the technical background, program scope, and delineates the responsibilities of each principal participant in the program.

  20. Postoperative Complications of Total Joint Arthroplasty in Obese Patients Stratified by BMI.

    Science.gov (United States)

    Zusmanovich, Mikhail; Kester, Benjamin S; Schwarzkopf, Ran

    2018-03-01

    High body mass index (BMI) is associated with significant complications in patients undergoing total joint arthroplasty. Many studies have evaluated this trend, but few have looked at the rates of complications based on BMI as a continuous variable. The purpose of this study was to stratify obese patients into 3 BMI categories and evaluate their rates of complications and gauge whether transitioning from higher to lower BMI category lowers complication. Patients undergoing primary total joint arthroplasty were selected from the National Surgical Quality Improvement Program database from 2008-2015 and arranged into 3 groups based on BMI: O1 (BMI 30-34.9 kg/m 2 ), O2 (BMI 35-39.9 kg/m 2 ), and O3 (BMI >40 kg/m 2 ). Thirty-day complications were recorded and evaluated utilizing univariate and multivariate analyses stratified by BMI. A total of 268,663 patients were identified. Patients with a BMI >30 kg/m 2 had more infectious and medical complications compared with nonobese patients. Furthermore, there were increased complications as the BMI categories increased. Patients with a BMI >40 kg/m 2 (O3) had longer operating times, length of stay, higher rates of readmissions, reoperations, deep venous thrombosis, renal insufficiency, superficial infections, deep infections, and wound dehiscence. These trends were present when comparing the O2 with O1 category as well. We have demonstrated increased rates of medical and surgical complications in obese patients. Furthermore, we demonstrated a stepwise increase in complication rates when transitioning to higher BMI groups. Based on our data, we believe that preoperative counseling and interventions to decrease BMI should be explored before offering elective surgery to obese patients. Copyright © 2017 Elsevier Inc. All rights reserved.