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Sample records for stabilizing cop location

  1. Stability of CoP x Electrocatalysts in Continuous and Interrupted Acidic Electrolysis of Water.

    Science.gov (United States)

    Goryachev, Andrey; Gao, Lu; Zhang, Yue; Rohling, Roderigh Y; Vervuurt, René H J; Bol, Ageeth A; Hofmann, Jan P; Hensen, Emiel J M

    2018-04-11

    Cobalt phosphides are an emerging earth-abundant alternative to platinum-group-metal-based electrocatalysts for the hydrogen evolution reaction (HER). Yet, their stability is inferior to platinum and compromises the large-scale applicability of CoP x in water electrolyzers. In the present study, we employed flat, thin CoP x electrodes prepared through the thermal phosphidation (PH 3 ) of Co 3 O 4 films made by plasma-enhanced atomic layer deposition to evaluate their stability in acidic water electrolysis by using a multi-technique approach. The films were found to be composed of two phases: CoP in the bulk and a P-rich surface CoP x (P/Co>1). Their performance was evaluated in the HER and the exchange current density was determined to be j 0 =-8.9 ⋅ 10 -5  A/cm 2 . The apparent activation energy of HER on CoP x ( E a =81±15 kJ/mol) was determined for the first time. Dissolution of the material in 0.5 M H 2 SO 4 was observed, regardless of the constantly applied cathodic potential, pointing towards a chemical instead of an electrochemical origin of the observed cathodic instability. The current density and HER faradaic efficiency (FE) were found to be stable during chronoamperometric treatment, as the chemical composition of the HER-active phase remained unchanged. On the contrary, a dynamic potential change performed in a repeated way facilitated dissolution of the film, yielding its complete degradation within 5 h. There, the FE was also found to be changing. An oxidative route of CoP x dissolution has also been proposed.

  2. COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

    Science.gov (United States)

    Wang, Hongjie; Dey, Debleena; Carrera, Ivan; Minond, Dmitriy; Bianchi, Elisabetta; Xu, Shaohua; Lakshmana, Madepalli K

    2013-09-13

    Increased processing of amyloid precursor protein (APP) and accumulation of neurotoxic amyloid β peptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Therefore, the identification of molecules that regulate Aβ generation is crucial for future therapeutic approaches for AD. We demonstrated previously that RanBP9 regulates Aβ generation in a number of cell lines and primary neuronal cultures by forming tripartite protein complexes with APP, low-density lipoprotein-related protein, and BACE1, consequently leading to increased amyloid plaque burden in the brain. RanBP9 is a scaffold protein that exists and functions in multiprotein complexes. To identify other proteins that may bind RanBP9 and regulate Aβ levels, we used a two-hybrid analysis against a human brain cDNA library and identified COPS5 as a novel RanBP9-interacting protein. This interaction was confirmed by coimmunoprecipitation experiments in both neuronal and non-neuronal cells and mouse brain. Colocalization of COPS5 and RanBP9 in the same subcellular compartments further supported the interaction of both proteins. Furthermore, like RanBP9, COPS5 robustly increased Aβ generation, followed by increased soluble APP-β (sAPP-β) and decreased soluble-APP-α (sAPP-α) levels. Most importantly, down-regulation of COPS5 by siRNAs reduced Aβ generation, implying that endogenous COPS5 regulates Aβ generation. Finally, COPS5 levels were increased significantly in AD brains and APΔE9 transgenic mice, and overexpression of COPS5 strongly increased RanBP9 protein levels by increasing its half-life. Taken together, these results suggest that COPS5 increases Aβ generation by increasing RanBP9 levels. Thus, COPS5 is a novel RanBP9-binding protein that increases APP processing and Aβ generation by stabilizing RanBP9 protein levels.

  3. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis.

    Science.gov (United States)

    Maier, Alexander; Schrader, Andrea; Kokkelink, Leonie; Falke, Christian; Welter, Bastian; Iniesto, Elisa; Rubio, Vicente; Uhrig, Joachim F; Hülskamp, Martin; Hoecker, Ute

    2013-05-01

    Anthocyanins are natural pigments that accumulate only in light-grown and not in dark-grown Arabidopsis plants. Repression of anthocyanin accumulation in darkness requires the CONSTITUTIVELY PHOTOMORPHOGENIC1/SUPPRESSOR OF PHYA-105 (COP1/SPA) ubiquitin ligase, as cop1 and spa mutants produce anthocyanins also in the dark. Here, we show that COP1 and SPA proteins interact with the myeloblastosis (MYB) transcription factors PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP)1 and PAP2, two members of a small protein family that is required for anthocyanin accumulation and for the expression of structural genes in the anthocyanin biosynthesis pathway. The increased anthocyanin levels in cop1 mutants requires the PAP1 gene family, indicating that COP1 functions upstream of the PAP1 gene family. PAP1 and PAP2 proteins are degraded in the dark and this degradation is dependent on the proteasome and on COP1. Hence, the light requirement for anthocyanin biosynthesis results, at least in part, from the light-mediated stabilization of PAP1 and PAP2. Consistent with this conclusion, moderate overexpression of PAP1 leads to an increase in anthocyanin levels only in the light and not in darkness. Here we show that SPA genes are also required for reducing PAP1 and PAP2 transcript levels in dark-grown seedlings. Taken together, these results indicate that the COP1/SPA complex affects PAP1 and PAP2 both transcriptionally and post-translationally. Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

  4. YIELD STABILITY OF NEW HYBRID RICE ACROSS LOCATIONS

    Directory of Open Access Journals (Sweden)

    Satoto

    2016-02-01

    Full Text Available The adaptation of hybrid rice varieties mostly are in specific location and season, but there are some of the varieties have a wide adaptation then adopted by the farmer in the large area. Replicated yield trials were conducted to study the stability of hybrid rice yield and identify the best location to optimize their yield per ha. The trials were conducted in three location such as Sukamandi, Salatiga and Malang during two seasons in 2011. Data across location and season were analazed by using AMMI and Eberhart Russel methods. The AMMI analysis showed that the IR79156A/PK88 was adaptable to favorable environments but unstable. This hybrid is always performing well and produce the higher yield compare to check variety. Some of other hybrids were good only in specific location, i.e. IR62829A/BP2280-1E-12-22 and IR58029A/BP2280-1E-12-22. Those hybrids produced higher yield in Salatiga and Malang, respectively. Seem to AMMI analysis, the result of Eberhart and Russell method also showed that IR79156A/PK81 was the best hybrid with regression slope (b around 1 with the yield average higher than average of all hybrids. It indicated that this hybrid has a wide adaptation and probably can be cultivated in the wider ecosystem.

  5. COP21: defense stakes

    International Nuclear Information System (INIS)

    Coldefy, Alain; Hulot, Nicolas; Aichi, Leila; Tertrais, Bruno; Paillard, Christophe-Alexandre; Piodi, Jerome; Regnier, Serge; Volpi, Jean-Luc; Descleves, Emmanuel; Garcin, Thierry; Granholm, Niklas; Wedin, Lars; Pouvreau, Ana; Henninger, Laurent

    2015-01-01

    The 21. Conference of the Parties (COP21) from the UN Framework Convention took place in Paris between November 30 and December 11, 2015. The challenge is to reach a universal agreement of fight against global warming and to control the carbon footprint of human activities. This topic is in the core of the Defense Ministry preoccupations. This special dossier takes stock of the question of defense issues linked with global warming. The dossier comprises 13 papers dealing with: 1 - COP21: defense stakes (Coldefy, A.); 2 - Warfare climate, a chance for peace (Hulot, N.); 3 - COP21 and defense (Aichi, L.); 4 - A war climate? (Tertrais, B.); 5 - Challenges the World has to face in the 21. century (Paillard, C.A.); 6 - Desertification: a time bomb in the heart of Sahel (Piodi, J.); 7 - The infrastructure department of defense in the fight against climate disturbance (Regnier, S.); 8 - Fight against global warming, a chance for the forces? (Volpi, J.L.); 9 - Sea and sustainable development (Descleves, E.); 10 - Rationales of Arctic's surrounding powers (Garcin, T.); 11 - Arctic: strategic stake (Granholm, N.; Wedin, L.); 12 - Strategic impact of Turkey's new energy choices (Pouvreau, A.); 13 - Climate and war: a brief historical outlook (Henninger, L.)

  6. Jasmonate inhibits COP1 activity to suppress hypocotyl elongation and promote cotyledon opening in etiolated Arabidopsis seedlings.

    Science.gov (United States)

    Zheng, Yuyu; Cui, Xuefei; Su, Liang; Fang, Shuang; Chu, Jinfang; Gong, Qingqiu; Yang, Jianping; Zhu, Ziqiang

    2017-06-01

    A germinating seedling undergoes skotomorphogenesis to emerge from the soil and reach for light. During this phase, the cotyledons are closed, and the hypocotyl elongates. Upon exposure to light, the seedling rapidly switches to photomorphogenesis by opening its cotyledons and suppressing hypocotyl elongation. The E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) is critical for maintaining skotomorphogenesis. Here, we report that jasmonate (JA) suppresses hypocotyl elongation and stimulates cotyledon opening in etiolated seedlings, partially phenocopying cop1 mutants in the dark. We also find that JA stabilizes several COP1-targeted transcription factors in a COP1-dependent manner. RNA-seq analysis further defines a JA-light co-modulated and cop1-dependent transcriptome, which is enriched for auxin-responsive genes and genes participating in cell wall modification. JA suppresses COP1 activity through at least two distinct mechanisms: decreasing COP1 protein accumulation in the nucleus; and reducing the physical interaction between COP1 and its activator, SUPPRESSOR OF PHYTOCHROME A-105 1 (SPA1). Our work reveals that JA suppresses COP1 activity to stabilize COP1 targets, thereby inhibiting hypocotyl elongation and stimulating cotyledon unfolding in etiolated Arabidopsis seedlings. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  7. Pointwise Stabilization of a Hybrid System and Optimal Location of Actuator

    International Nuclear Information System (INIS)

    Ammari, Kais; Saidi, Abdelkader

    2007-01-01

    We consider a pointwise stabilization problem for a model arising in the control of noise. We prove that we have exponential stability for the low frequencies but not for the high frequencies. Thus, we give an explicit polynomial decay estimation at high frequencies that is valid for regular initial data while clarifying that the behavior of the constant which intervenes in this estimation there, functions as the frequency of cut. We propose a numerical approximation of the model and study numerically the best location of the actuator at low frequencies

  8. COP21, The Force Awakens

    International Nuclear Information System (INIS)

    2015-01-01

    After four years of hard work, the COP21 has culminated in a climate agreement that was accepted by 195 countries. This agreement is the first to involve all world economies in the fight against climate change. Beyond the pledges made by the governments, the COP21 also aimed to highlight solutions that are backed by the private sector. A testimony to companies' determination to become a part of the movement, several initiatives were launched in a wide range of sectors over the course of the two conference weeks. Responding to these transformations, the financial sector also made several announcements, promising that it would divest from the most polluting energies, increase investments in clean technologies, stimulate financial innovation (green bonds, LDN) and measure carbon footprints. Investors have understood once and for all that they must adapt their investment strategies if they want to face up to the challenges of the current transition to a low carbon economy

  9. Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study.

    Science.gov (United States)

    Gunawardene, Piumali; Al Saedi, Ahmed; Singh, Lakshman; Bermeo, Sandra; Vogrin, Sara; Phu, Steven; Suriyaarachchi, Pushpa; Pignolo, Robert J; Duque, Gustavo

    2017-10-01

    Circulating osteoprogenitor (COP) cells are blood-borne cells which express a variety of osteoblastic markers and are able to form bone nodules in vivo. Whereas a high percentage of COP cells (%COP) is associated with vascular calcification, low %COP has been associated with disability and frailty. However, the reference range of %COP in age- and gender-matching populations, and the age-related changes in %COP remain unknown. A cross-sectional study was undertaken in 144 healthy volunteers in Western Sydney (20-90year-old, 10 male and 10 female subjects per decade). %COP was quantified by flow cytometry. A high inter-and intra-rater reliability was found. In average, in this healthy population average of %COP was 0.42. There was no significant difference in %COP among the age groups. Similarly, no significant difference was found in %COP with gender, weight, height or BMI. In addition, we identified a normal reference range of %COP of 0.1-3.8%. In conclusion, in addition to the identification of steady levels of COP cells with age, we also identified a normal reference range of %COP, which could be used in future studies looking at musculoskeletal diseases in older populations. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. [Model of the system for stabilizing the frequency of the echosignal of the Rhinolophus locator].

    Science.gov (United States)

    Livshits, M S; Pokotilo, G P

    1977-01-01

    Physical analysis of anatomic, physiological and behavioural data pertaining to the work of Rhinolophidae echolocator is carried out, results of spectral analysis of its probing impulse are analysed. On this basis the working mechanism of sound emitting apparatus is proposed. A phenomenological model of the frequency stabilization system of the signal reflected from a located object is constructed. This stabilization is carried out by the compensation of Doppler shift of the echo frequency by a change of the generated impulse frequency. Due to the application of a differential method the model provides for potential accuracy of tuning, and its work does not depend on the value of a reflected signal and its sufficiently small changes which is in agreement with the experiments.

  11. Salt Stress and Ethylene Antagonistically Regulate Nucleocytoplasmic Partitioning of COP1 to Control Seed Germination.

    Science.gov (United States)

    Yu, Yanwen; Wang, Juan; Shi, Hui; Gu, Juntao; Dong, Jingao; Deng, Xing Wang; Huang, Rongfeng

    2016-04-01

    Seed germination, a critical stage initiating the life cycle of a plant, is severely affected by salt stress. However, the underlying mechanism of salt inhibition of seed germination (SSG) is unclear. Here, we report that the Arabidopsis (Arabidopsis thaliana) CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1) counteracts SSG Genetic assays provide evidence that SSG in loss of function of the COP1 mutant was stronger than this in the wild type. A GUS-COP1 fusion was constitutively localized to the nucleus in radicle cells. Salt treatment caused COP1 to be retained in the cytosol, but the addition of ethylene precursor 1-aminocyclopropane-1-carboxylate had the reverse effect on the translocation of COP1 to the nucleus, revealing that ethylene and salt exert opposite regulatory effects on the localization of COP1 in germinating seeds. However, loss of function of the ETHYLENE INSENSITIVE3 (EIN3) mutant impaired the ethylene-mediated rescue of the salt restriction of COP1 to the nucleus. Further research showed that the interaction between COP1 and LONG HYPOCOTYL5 (HY5) had a role in SSG Correspondingly, SSG in loss of function of HY5 was suppressed. Biochemical detection showed that salt promoted the stabilization of HY5, whereas ethylene restricted its accumulation. Furthermore, salt treatment stimulated and ethylene suppressed transcription of ABA INSENSITIVE5 (ABI5), which was directly transcriptionally regulated by HY5. Together, our results reveal that salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1, thereby controlling Arabidopsis seed germination via the COP1-mediated down-regulation of HY5 and ABI5. These findings enhance our understanding of the stress response and have great potential for application in agricultural production. © 2016 American Society of Plant Biologists. All Rights Reserved.

  12. From COP21 to COP22: Keeping up the Momentum

    International Nuclear Information System (INIS)

    Mathieu, Carole

    2016-10-01

    In December 2015, a new international climate agreement was adopted, paving the way for increased mitigation and adaptation efforts. Governments firmly expressed the need for rapid action and 2016 will put the credibility of their commitments to the test. This article argues that climate policies are actually becoming more widespread, but they are also adjusting to local constraints and needs, suggesting that the establishment of a global emission regulation model is unlikely in the near future. While the low-carbon transition is well under way, its pace and conditions still appear too uncertain to fully convince economic decision-makers of the value of carbon-free options. COP22, which will take place in Marrakech in November 2016, will be an opportunity to leave these hesitations behind by strengthening mutual oversight, by consolidating the principle of climate justice, and by furthering the discussion about the best ways to orchestrate the transition to carbon neutrality

  13. Climate change negotiations. COP-2 and beyond

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    The Second Conference of the Parties to the UN Framework Convention on Climate Change (COP-2), which met in Geneva during July, 1996, was only a partial success when considered in relation to its avowed aims, gaining acceptance of the Second Assessment Report by IPCC (Intergovernmental Panel on Climate Change), producing an agreed Ministerial Declaration, making real advances towards a protocol, and agreeing Rules of Procedure. This paper describes the main aims of COP-2, consideration of and response to the IPCC`s Second Assessment Report, the COP-2 Ministerial Declaration, some significant statements by individual country delegations at COP-2, lack of progress on Rules of Procedure for the Conference, realization of returning the greenhouse gas emissions in industrialized countries based on the Montreal Protocol, differing views among countries to the Convention on a protocol, prospects for achieving agreement on a legally binding protocol at COP-3 planned for Kyoto, Japan in December, 1997, and recent scientific and technical findings.

  14. COP 21: the national contributions

    International Nuclear Information System (INIS)

    Jouette, Isabelle

    2015-01-01

    This article comments the content of the national contributions (the so-called Intended Nationally Determined Contributions or INDC) which every country should have transmitted to the UN before the COP 21. In fact, 148 contributions, i.e. 75 per cent of the expected ones, have been transmitted. The author recalls that the content of these contributions had to obey some principles which had been defined in Lima in 2014, and that each country must identify its objectives in terms of mitigation (reduction of greenhouse gas emissions) and adaptation (reduction of the vulnerability of natural and human systems). The author comments some specific commitments regarding climate, emission reduction, adaptation to climate change, and more particularly evokes the Ethiopian contribution which is considered as exemplary

  15. COP-21: the economic controversy

    International Nuclear Information System (INIS)

    Huet, Sylvestre

    2015-01-01

    This publication analyses and discusses the content of the so-called 'intended nationally determined contributions' (INDC) prepared by countries for the COP-21. It notably shows that the USA projected energy consumption is in total contradiction with the contribution. It outlines that some of these contributions sound too ambitious in terms of reduction of greenhouse gas emissions. In fact, these statements are important for poor countries to obtain financial support from rich countries. The perspective of temperature increase is not good, but it seems that everybody is now aware of the associated risks. The article outlines that commitments for actions remain far behind the objectives defined in Copenhagen. The fact that fossil energies are cheap favours their use, that which is a problem with respect to general commitments for climate. The limitations of present alternate solutions are discussed: green oil, hydraulic, electricity production based on wind and solar energy, use of geothermal for heat or electricity, nuclear fission, nuclear fusion

  16. COP 21: words... and acts?

    International Nuclear Information System (INIS)

    Combe, Matthieu

    2015-01-01

    Published shortly before the Paris COP 21, this set of articles first recalls what is this Conference of Parties, and what will be the objectives in Paris: an agreement for the struggle against climate change, a reduction of greenhouse emissions, how to adapt to climate change. It also indicates some quantitative measurements and objectives regarding global warming according to the IPCC. The author outlines commitments for countries which signed the United Nations Framework Convention on Climate Change (UNFCCC), presents and discusses the content of the first and second Kyoto protocols, and outlines that a ratification of the second Kyoto protocol would already be a strong message. A second article notices that the objective of a maximum of a 2 degree increase of the global temperature seems difficult to be met when considering the Intended Nationally Determined Contributions or INDCs issued by a large part of the involved countries. The author discusses the issue of CO 2 budget available per inhabitant. A third article addresses the 2009 Copenhagen commitment for developed countries to give 100 billions dollars by 2020 to developing countries to finance their adaptation policy and to promote low carbon technologies. He comments the present level of these climatic financing, wanders how the still missing billions will be found, and whether these 100 billions will be enough. The fourth and last article discusses the position of the main oil and gas companies regarding climate change, and outlines that a British NGO denounced the gap between their statements and their lobbying actions

  17. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location.

    Science.gov (United States)

    Haran, John P; Bucci, Vanni; Dutta, Protiva; Ward, Doyle; McCormick, Beth

    2018-01-01

    The microbiome from nursing home (NH) residents is marked by a loss in diversity that is associated with increased frailty. Our objective was to explore the associations of NH environment, frailty, nutritional status and residents' age to microbiome composition and potential metabolic function. We conducted a prospective longitudinal cohort study of 23 residents, 65 years or older, from one NH that had four floors: two separate medical intensive floors and two floors with active elders. Residents were assessed using the mini nutritional assessment tool and clinical frailty scale. Bacterial composition and metabolic potential of residents' stool samples was determined by metagenomic sequencing. We performed traditional unsupervised correspondence analysis and linear mixed effect modelling regression to assess the bacteria and functional pathways significantly affected by these covariates.Results/Key findings. NH resident microbiomes demonstrated temporal stability (PERMANOVA P=0.001) and differing dysbiotic associations with increasing age, frailty and malnutrition scores. As residents aged, the abundance of microbiota-encoded genes and pathways related to essential amino acid, nitrogenous base and vitamin B production declined. With increasing frailty, residents had lower abundances of butyrate-producing organisms, which are associated with increased health and higher abundances of known dysbiotic species. As residents became malnourished, butyrate-producing organisms declined and dysbiotic bacterial species increased. Finally, the microbiome of residents living in proximity shared similar species and, as demonstrated for Escherichia coli, similar strains. These findings support the conclusion that a signature 'NH' microbiota may exist that is affected by the residents' age, frailty, nutritional status and physical location.

  18. Synthesis of NiPS3 and CoPS and its hydrogen storage capacity

    International Nuclear Information System (INIS)

    Ismail, N.; Madian, M.; El-Meligi, A.A.

    2014-01-01

    Highlights: • Preparation of NiPS 3 and CoPS using solid state reaction. • Characterization of compounds using XRD, TEM, SEM and IR. • Measuring the compounds thermal stability. • Estimation of the hydrogen storage capacity. -- Abstract: Prepared CoPS and NiPS 3 are studied as new materials for hydrogen energy storage. Single phase of CoPS and NiPS 3 were grown separately in evacuated silicatube via solid state reaction at 650 °C with controlled heating rate 1 °C/min. X-ray diffraction patterns confirm the formation of the desired compounds. Both CoPS and NiPS 3 exhibited high thermal stability up to 700 °C and 630 °C, respectively. The morphology of the prepared samples was investigated using scanning electron microscopy and folded sheets appeared in the transmission electron microscopy. The samples were exposed to 20 bar applied hydrogen pressure at 80 K. Both compounds appear to have feasible hydrogen storage capacity. CoPS was capable to adsorb 1.7 wt% while NiPS 3 storage capacity reached 1.2 wt%

  19. COP 21: a diplomatic and... climatic success?

    International Nuclear Information System (INIS)

    Combe, Matthieu

    2016-09-01

    If the agreement signed at the end of the COP21 has been greeted as historical, compromises made for such a diplomatic success cast doubt on the constraining aspect of this treaty. This publication thus proposes comments on the content of the COP21 agreement by discussing the perspective and opportunities of a possible commitment of air transport in the struggle against climate change, by questioning the existence of a dynamics for world commitment in the development of renewable energies, for the emergence of more responsible companies and sustainable cities, by commenting the almost unanimous success of the COP21 acknowledged by all parties (except Nicaragua), by commenting the opinion of NGOs on the agreement. Other articles evoke and comment examples of mobilisation of civil society and companies in demonstrations during the COP21, other demonstrations organised in parallel with the COP21 (a citizen summit on climate in Montreuil, exhibition in the Grand Palais where large companies like Veolia, L'Oreal, Evian, BIC, Coca-Cola or Renault presented some initiatives)

  20. Evaluation of Need and Location for a Thermogravimetric Analyzer in the Plutonium Finishing Plant (PFP) Materials Stabilization

    International Nuclear Information System (INIS)

    WILLIS, H.T.

    2000-01-01

    This plan provides an analysis for locating a TGA to support PFP Thermal Stabilization processes. The scope of this document is to evaluate the need for, and location for, installation of a TGA system as a supplement to the SFE equipment for moisture measurement in pure oxides. A location assessment for the SFE equipment was previously performed (HNF 1999). Based on that assessment, co-location of the TGA system with the SFE system is the preferred option. This would enable thermally stabilized material to be analyzed for residual moisture by either the TGA system or SFE system or both This evaluation considers glovebox locations in the PFP 234-52 Building Analytical Laboratory or operating areas for the installation of the TGA system and it's supporting equipment. This evaluation considers using existing gloveboxes along with an alternative of adding a new glovebox to existing process lines. The location evaluation criteria focuses mainly on glovebox size, with qualitative consideration of relative cost and schedule impacts associated with system implementation, radiological control, and interaction with other laboratory operations and processes. In addition, the possible co-location of a TGA furnace system with the SFE system was considered

  1. Using trajectory sensitivity analysis to find suitable locations of series compensators for improving rotor angle stability

    DEFF Research Database (Denmark)

    Nasri, Amin; Eriksson, Robert; Ghandhar, Mehrdad

    2014-01-01

    This paper proposes an approach based on trajectory sensitivity analysis (TSA) to find most suitable placement of series compensators in the power system. The main objective is to maximize the benefit of these devices in order to enhance the rotor angle stability. This approach is formulated...

  2. Locating Critical Circular and Unconstrained Failure Surface in Slope Stability Analysis with Tailored Genetic Algorithm

    Science.gov (United States)

    Pasik, Tomasz; van der Meij, Raymond

    2017-12-01

    This article presents an efficient search method for representative circular and unconstrained slip surfaces with the use of the tailored genetic algorithm. Searches for unconstrained slip planes with rigid equilibrium methods are yet uncommon in engineering practice, and little publications regarding truly free slip planes exist. The proposed method presents an effective procedure being the result of the right combination of initial population type, selection, crossover and mutation method. The procedure needs little computational effort to find the optimum, unconstrained slip plane. The methodology described in this paper is implemented using Mathematica. The implementation, along with further explanations, is fully presented so the results can be reproduced. Sample slope stability calculations are performed for four cases, along with a detailed result interpretation. Two cases are compared with analyses described in earlier publications. The remaining two are practical cases of slope stability analyses of dikes in Netherlands. These four cases show the benefits of analyzing slope stability with a rigid equilibrium method combined with a genetic algorithm. The paper concludes by describing possibilities and limitations of using the genetic algorithm in the context of the slope stability problem.

  3. COP of heat pumps. From definition to sales promotion; Warmtepomp COP. Van definitie tot verkoopargument

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomeus, T.M.C. [Grasso Products, Den Bosch (Netherlands)

    2006-10-15

    Due to new EU-regulations heat pumps are once more very much in demand. A negative side effect of this popularity is the incomplete and defective information overrunning the market. The COP (coefficient of performance) of a heat pump degenerates from a definition into a sales promotion. This article brings clearness in these COP matters. [Dutch] Het blijkt dat de markt voor warmtepompen wordt overspoeld met onvolledige informatie ten gunste van hogere verkoopcijfers. Het rendement van een warmtepomp, verpakt in het Engelse COP (coefficient of performance) verwordt van definitie tot verkoopargument. In principe is daar niets mis mee, maar weI als het te pas en onpas gebruikt wordt, zonder enige relatie met het gebruiksdoel, de toepassing en bedrijfsvoering. Dit artikel heeft als doel om appels en peren in de COP-communicatie te scheiden.

  4. Crosswind stability of FSAE race car considering the location of the pressure center

    Science.gov (United States)

    Zhao, Lijun; He, Huimin; Wang, Jianfeng; Li, Yaou; Yang, Na; Liu, Yiqun

    2017-09-01

    An 8-DOF vehicle dynamic model of FSAE race car was established, including the lateral motion, pitch motion, roll motion, yaw motion and four tires rotation. The model of aerodynamic lateral force and pressure center model were set up based on the vehicle speed and crosswind parameters. The simulation model was built by Simulink, to analyse the crosswind stability for straight-line condition. Results showed that crosswind influences the yawing velocity and sideslip angle seriously.

  5. Stability of GNSS Monumentation: Analysis of Co-Located Monuments in the UNAVCO Plate Boundary Observatory

    Science.gov (United States)

    Blume, F.; Herring, T.; Mattioli, G. S.; Feaux, K.; Walls, C. P.; Austin, K. E.; Dittmann, S. T.

    2017-12-01

    Geodetic-quality permanent GNSS stations have used a number of different monument styles for the purpose of ensuring that the motions of the GNSS antenna reflect those of the Earth's crust while minimizing non-tectonic motions near the surface. Monuments range from simple masts mounted on buildings or drilled into bedrock, costing a few hundred dollars to machine-drilled-braced monuments in soil costing tens of thousands. The stability of an individual monument will depend on its design, the construction techniques used to install it, and the local surface geology where it is installed. Previous studies have separately investigated pairs of identical monuments at a single site, monument type performance using global statistical analysis, and multiple monument styles at a single site, yet the stability of different monument types in similar geologic conditions has not been adequately determined. To better characterize the stability of various monument styles in diverse geologic conditions UNAVCO constructed two additional monuments at five existing PBO stations in 2013. Deep drilled-braced, short drilled-braced, and single mast type monuments were installed at sites with bedrock at the surface; deep drilled-braced, short driven-braced and pillar type monuments were installed at sites with alluvium or soil at the surface. The sites include a variety of geographic, hydrologic, and geologic conditions. Data collected from the PBO Multi-Monument Experiment have been analyzed using a variety of methods. Each site is characterized using quality-control parameters such as multipath, signal-to-noise and previously determined seasonal variations. High-precision processing by PBO Analysis Centers with GAMIT and GIPSY use regional and global schemes and yield time-series with millimeter-level that determine noise content, overall site stability relative to other PBO sites and differential motions between the individual monuments. Sub-millimeter results from single

  6. Location, location, location

    NARCIS (Netherlands)

    Anderson, S.P.; Goeree, J.K.; Ramer, R.

    1997-01-01

    We analyze the canonical location-then-price duopoly game with general log- concave consumer densities. A unique pure-strategy equilibrium to the two-stage game exists if the density is not "too asymmetric" and not "too concave." These criteria are satisfied by many commonly used densities.

  7. The stability of retained austenite at different locations during straining of I&Q&P steel

    Energy Technology Data Exchange (ETDEWEB)

    Song, Chenghao [School of Materials Science and Engineering, University of Science & Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Yu, Hao, E-mail: yuhao@ustb.edu.cn [School of Materials Science and Engineering, University of Science & Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Li, Lili; Zhou, Tao; Lu, Jun [School of Materials Science and Engineering, University of Science & Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing 100083 (China); Liu, Xihui [Qingzhou Construction Quality and Safety Supervision Station, Shandong 262500 (China)

    2016-07-18

    This paper presents a detailed investigation of the transformation behavior of retained austenite at different locations of intercritical heating, quenching and partitioning (I&Q&P) steel. The consumption of retained austenite at different strains is investigated by X-ray diffraction (XRD). Results indicate that retained austenite can transform into martensite progressively during the whole deformation process, which is in favor of a good combination of strength and ductility, contributing to a high product of strength and elongation (PSE) of 31.9 GPa%. The transformation characteristics of retained austenite at different locations after different strains are characterized by electron back scattered diffraction (EBSD) and transmission electron microscopy (TEM). Results show that the transformation preferentially occurs in the retained austenite at ferrite grain boundaries, subsequently the one within ferrite grains (at 10% strain) and eventually the one between martensite laths (at 15% strain). In FCC phase, the average local misorientations are 0.547° and 0.674° at 5% and 10% strain, respectively; however, the values are not more than 0.7° at 15% and 20% strain due to the TRIP effect. For the retained austenite within ferrite grains, the interior part preferentially transforms into twin martensite, while the interface still remains due to alloying elements segregation.

  8. DHU1 negatively regulates UV-B signaling via its direct interaction with COP1 and RUP1.

    Science.gov (United States)

    Kim, Sang-Hoon; Kim, Hani; Chung, Sunglan; Lee, Jae-Hoon

    2017-09-16

    Although DWD HYPERSENSITIVE TO UV-B 1 (DHU1) is reported to be a negative regulator in UV-B mediated cellular responses, its detailed role in UV-B signaling is still elusive. To further understand the action mechanism of DHU1 in UV-B response, physical and genetic interactions of DHU1 with various UV-B signaling components were investigated. Yeast two hybrid assay results suggested that DHU1 directly interacts with COP1 and RUP1, implying a functional connection with both COP1 and RUP1. In spite of the physical association between DHU1 and COP1, loss of DHU1 did not affect protein stability of COP1. Epistatic analysis showed that the functional loss of both DHU1 and UVR8 leads to alleviation of UV-B hypersensitivity displayed in dhu1-1. Moreover, phenotypic studies with dhu1-1 cop1-6 and dhu1-1 hy5-215 revealed that COP1 and HY5 are epistatic to DHU1, indicating that UV-B hypersensitivity of dhu1-1 requires both COP1 and HY5. In the case of dhu1-1 rup1-1, UV-B responsiveness was similar to that of both dhu1-1 and rup1-1, implying that DHU1 and RUP1 are required for each other's function. Collectively, these results show that the role of DHU1 as a negative regulator in UV-B response may be derived from its direct interaction with COP1 by sequestering COP1 from the active UVR8-COP1 complex, resulting in a decrease in the COP1 population that positively participates in UV-B signaling together with UVR8. Furthermore, this inhibitory role of DHU1 in UV-B signaling is likely to be functionally connected to RUP1. This study will serve as a platform to further understand more detailed action mechanism of DHU1 in UV-B response and DHU1-mediated core UV-B signaling in Arabidopsis. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Big Data-Based Approach to Detect, Locate, and Enhance the Stability of an Unplanned Microgrid Islanding

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Huaiguang; Li, Yan; Zhang, Yingchen; Zhang, Jun Jason; Gao, David Wenzhong; Muljadi, Eduard; Gu, Yi

    2017-10-01

    In this paper, a big data-based approach is proposed for the security improvement of an unplanned microgrid islanding (UMI). The proposed approach contains two major steps: the first step is big data analysis of wide-area monitoring to detect a UMI and locate it; the second step is particle swarm optimization (PSO)-based stability enhancement for the UMI. First, an optimal synchrophasor measurement device selection (OSMDS) and matching pursuit decomposition (MPD)-based spatial-temporal analysis approach is proposed to significantly reduce the volume of data while keeping appropriate information from the synchrophasor measurements. Second, a random forest-based ensemble learning approach is trained to detect the UMI. When combined with grid topology, the UMI can be located. Then the stability problem of the UMI is formulated as an optimization problem and the PSO is used to find the optimal operational parameters of the UMI. An eigenvalue-based multiobjective function is proposed, which aims to improve the damping and dynamic characteristics of the UMI. Finally, the simulation results demonstrate the effectiveness and robustness of the proposed approach.

  10. LONG-TERM STABILITY OF THE LOCAL GROUND CONTROL NETWORK AT THE CO-LOCATION SITE OF MEDICINA

    Science.gov (United States)

    Abbondanza, C.; Sarti, P.; Legrand, J.

    2009-12-01

    ITRF combinations rely on the availability of accurate tie vectors linking reference points of space geodetic techniques. Co-located instruments are assumed to move consistently and no local relative motion is taken into account. Instabilities may degrade the quality of the co-location itself and perturb the result of ITRF combinations. This work aims to determine the stability of the local ground control network at Medicina (Italy) with independent surveying methods. The observatory hosts a co-location between a VLBI telescope and two GPS antennas, MEDI and MSEL. It is located in the Po Plain where thick layers of clays are the prevalent soil characteristics. Hence, provision of long term stability of geodetic monuments is a challenge and monitoring their stability is an issue. MEDI and the VLBI station regularly contribute to the determination of ITRF, while MSEL is part of the EUREF network. A set of five tie vectors observations linking the VLBI and MEDI reference points was acquired between 2001 and 2007. It is our main tool for performing local deformation analysis. Additionally, the GPS time series of MEDI and MSEL were used to cross check and confirm the local instability detected by terrestrial methods. To achieve a rigorous and reliable investigation of the local stability, multi-epoch terrestrial observations were homogeneously processed according to common parameterizations in a consistent reference frame. Similarly, continuous GPS observations from MEDI and MSEL were analysed according to the new EPN reprocessing strategy in order to monitor the short baseline between MEDI and MSEL; to spotlight any change in its length. Both approaches confirm differential motions at the site which can be related to monument instabilities originated by the particularly unfavourable local geological setting and the inapt design of the monuments foundation. The monuments move non homogeneously at rates reaching up to 1.6 mm/year, this value being comparable to intra

  11. COP21. To change the energy model

    International Nuclear Information System (INIS)

    Dupin, Ludovic

    2015-01-01

    In this brief article, the author regrets that the final COP21 agreement mentioned only once the energy issue whereas energy is responsible of 66 per cent of CO 2 emissions. Commitments regarding financing are evoked as well as statements made by the US President and his Secretary of State. He briefly outlines evolutions noticed in Germany after the implementation of the new energy policy (Energiewende) and its possible influences in other countries, notably in France. The still important role of coal in some countries like China, India, and Africa is outlined. Saudi Arabia succeeded in avoiding any mention of fossil energies in the final agreement

  12. COP-6: Anatomy of a breakdown

    International Nuclear Information System (INIS)

    Carpenter, C.; Kellett, V.

    2000-01-01

    Failure of the sixth Conference of Parties (COP-6) meeting at the Hague, to reach agreement on translating the 1997 Kyoto Protocol into a detailed, enforceable treaty is discussed. Despite major efforts by the current President of COP the major negotiating blocs, namely the EU, the 'Umbrella group' (Canada, the U.S., Japan, Australia, New Zealand, Russia, Ukraine and Norway) and the G-77 and China ( a group of over 130 developing nations, including some OPEC countries) refused to depart from their long-standing positions, leading to sustained protests, occasional outbursts of violence and passport burnings by protesters. Despite the pessimism and mutual recriminations over the failure to reach agreement, leading to fears that the Kyoto Protocol might never be ratified, the second week of the conference, in fact, produced significant progress on some important issues. Optimists believe that the agreements reached might be sufficient to induce governments to address key unresolved issues, including how to account for carbon sinks (the most visible disagreement at COP-6, in which the EU accused Canada and the U.S. of trying to 'get something for nothing' by allowing countries with high forest and grassland cover to avoid real actions on climate change), use of the Kyoto Protocol's flexibility mechanisms (the Clean Development Mechanism, joint implementation and emissions credit trading, which would allow developed countries to carry out an emission reduction project in a developing country and claim the resulting credits against its own target), the compliance regime (which Parties to the Protocol will be governed by the regime; the consequences of non-compliance; who will decide when a party is not in compliance), and funding assistance for developing countries to encourage them to adapt to climate change (China and developing countries accused the industrialized nations of failing in their moral duty to provide money, technology and technical assistance to poorer

  13. COP-6: Anatomy of a breakdown

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, C.; Kellett, V. [International Institute for Sustainable Development, Ottawa, ON (Canada)

    2000-12-05

    Failure of the sixth Conference of Parties (COP-6) meeting at the Hague, to reach agreement on translating the 1997 Kyoto Protocol into a detailed, enforceable treaty is discussed. Despite major efforts by the current President of COP the major negotiating blocs, namely the EU, the 'Umbrella group' (Canada, the U.S., Japan, Australia, New Zealand, Russia, Ukraine and Norway) and the G-77 and China ( a group of over 130 developing nations, including some OPEC countries) refused to depart from their long-standing positions, leading to sustained protests, occasional outbursts of violence and passport burnings by protesters. Despite the pessimism and mutual recriminations over the failure to reach agreement, leading to fears that the Kyoto Protocol might never be ratified, the second week of the conference, in fact, produced significant progress on some important issues. Optimists believe that the agreements reached might be sufficient to induce governments to address key unresolved issues, including how to account for carbon sinks (the most visible disagreement at COP-6, in which the EU accused Canada and the U.S. of trying to 'get something for nothing' by allowing countries with high forest and grassland cover to avoid real actions on climate change), use of the Kyoto Protocol's flexibility mechanisms (the Clean Development Mechanism, joint implementation and emissions credit trading, which would allow developed countries to carry out an emission reduction project in a developing country and claim the resulting credits against its own target), the compliance regime (which Parties to the Protocol will be governed by the regime; the consequences of non-compliance; who will decide when a party is not in compliance), and funding assistance for developing countries to encourage them to adapt to climate change (China and developing countries accused the industrialized nations of failing in their moral duty to provide money, technology and

  14. COP 21: which role for the nuclear?

    International Nuclear Information System (INIS)

    Le Ngoc, Boris

    2015-01-01

    This publication discusses the opportunities and challenges of the 21. Conference of Parties (COP) or conference on climate change which will take place in France. It notably outlines how this conference could be successful, and the importance of the European Union for energy. It more precisely and deeply addresses the issues related to nuclear energy by outlining that this energy is part of the solution for the struggle against climate change, by outlining that Euratom could be an inspiring example for a European Union for energy, and by briefly proposing a way to finance nuclear energy. Some propositions made by an expert for the development of nuclear energy are reported

  15. Groundwater vulnerability assessment in karstic aquifers using COP method.

    Science.gov (United States)

    Bagherzadeh, Somayeh; Kalantari, Nasrollah; Nobandegani, Amir Fadaei; Derakhshan, Zahra; Conti, Gea Oliveri; Ferrante, Margherita; Malekahmadi, Roya

    2018-05-02

    Access to safe and reliable drinking water is amongst the important indicators of development in each society, and water scarcity is one of the challenges and limitations affecting development at national and regional levels and social life and economic activity areas. Generally, there are two types of drinking water sources: the first type is surface waters, including lakes, rivers, and streams and the second type is groundwaters existing in aquifers. Amongst aquifers, karst aquifers play an important role in supplying water sources of the world. Therefore, protecting these aquifers from pollution sources is of paramount importance. COP method is amongst the methods to investigate the intrinsic vulnerability of this type of aquifers, so that areas susceptible to contamination can be determined before being contaminated and these sources can be protected. In the present study, COP method was employed in order to spot the regions that are prone to contamination in the region. This method uses the properties of overlying geological layers above the water table (O factor), the concentration of flow (C factor), and precipitation (P factor) over the aquifer, as the parameters to assess the intrinsic vulnerability of groundwater resources. In this regard, geographical information system (GIS) and remote sensing (RS) were utilized to prepare the mentioned factors and the intrinsic vulnerability map was obtained. The results of COP method indicated that the northwest and the west of the region are highly and very vulnerable. This study indicated that regions with low vulnerability were observed in eastern areas, which accounted for 15.6% of the area. Moderate vulnerability was 40% and related to the northeast and southeast of the area. High vulnerability was 38.2% and related to western and southwestern regions. Very high vulnerability was 6.2% and related to the northwest of the area. By means of the analysis of sensitivity of the model, it was determined that the focus

  16. An Analysis of the Effects of Wing Aspect Ratio and Tail Location on Static Longitudinal Stability Below the Mach Number of Lift Divergence

    Science.gov (United States)

    Axelson, John A.; Crown, J. Conrad

    1948-01-01

    An analysis is presented of the influence of wing aspect ratio and tail location on the effects of compressibility upon static longitudinal stability. The investigation showed that the use of reduced wing aspect ratios or short tail lengths leads to serious reductions in high-speed stability and the possibility of high-speed instability.

  17. COP 23: Gender Equality and Climate Change

    Directory of Open Access Journals (Sweden)

    Struck-Garbe, Marion

    2018-03-01

    Full Text Available The World Climate Conference 2017 (COP 23 yielded the adoption of the first United Nations Framework Convention on Climate Change Gender Action Plan (GAP. This is a positive shift towards an integration of gender justice and human rights in the context of the UN Climate Action Plan. GAP necessitates importance granted to gender-equal climate policy and therefore, must be integrated into national climate action plans (programs. The first progress assessment will be conducted at COP 25 towards the end of 2019. However, while GAP recognizes women’s roles and importance with regard to climate change, it does not reach out beyond this. For instance, development policy measures that likewise play an important role have been excluded. In the Asia-Pacific the specific role of women as livelihood providers has received minimal attention and resultantly there has been little implementation of concrete measures. There are still many steps to be taken before deeper and more fundamental changes are reached.

  18. CoPs Facing Rationalization: The Politics of Community Reproduction

    Science.gov (United States)

    Kilskar, Stine Skaufel; Ingvaldsen, Jonas A.; Valle, Nina

    2018-01-01

    Purpose: This paper aims to explore the relationship between the contemporary forms of manufacturing rationalization and the reproduction of communities of practice (CoPs) centred on tasks and craft. Building on critical literature highlighting the tensions between CoPs and rationalization, this paper aims to develop a nuanced account of how CoPs…

  19. 32 CFR 635.24 - Updating the COPS MPRS.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Updating the COPS MPRS. 635.24 Section 635.24 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.24 Updating the COPS MPRS. Installation Provost Marshals/Directors of...

  20. COP 21/CMP11. Understanding the challenges

    International Nuclear Information System (INIS)

    2015-03-01

    By the end of 2015, France will host the 21. conference of parties (COP 21) of the United Nations Framework Convention on Climate Change. The goal is to reach an agreement between all countries in order to keep the global warming below 2 deg. C. In this perspective, French President Francois Hollande, urged France to be a role model at home, which is the prerequisite to convince and lead Europe and the rest of the world in this worldwide fight. This note explains what role France will have to play on the international scene, what is the position of France and Europe in the climate topic, and how electricity can contribute to the fight against global warming

  1. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity

    KAUST Repository

    Lin, Xiao-Li

    2016-04-29

    COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution in COP1 blocks its SUMO modification and reduces COP1 activity in vitro and in planta. Consistently, COP1 activity is reduced in siz1 and the level of HY5, a COP1 target protein, is increased in siz1. Sumoylated COP1 may exhibits higher transubiquitination activity than does non-sumoylated COP1, but SIZ1-mediated SUMO modification does not affect COP1 dimerization, COP1-HY5 interaction, and nuclear accumulation of COP1. Interestingly, prolonged light exposure reduces the sumoylation level of COP1, and COP1 mediates the ubiquitination and degradation of SIZ1. These regulatory mechanisms may maintain the homeostasis of COP1 activity, ensuing proper photomorphogenic development in changing light environment. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  2. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity

    KAUST Repository

    Lin, Xiao-Li; Niu, De; Hu, Zi-Liang; Kim, Dae Heon; Jin, Yin Hua; Cai, Bin; Liu, Peng; Miura, Kenji; Yun, Dae-Jin; Kim, Woe-Yeon; Lin, Rongcheng; Jin, Jing Bo

    2016-01-01

    COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution in COP1 blocks its SUMO modification and reduces COP1 activity in vitro and in planta. Consistently, COP1 activity is reduced in siz1 and the level of HY5, a COP1 target protein, is increased in siz1. Sumoylated COP1 may exhibits higher transubiquitination activity than does non-sumoylated COP1, but SIZ1-mediated SUMO modification does not affect COP1 dimerization, COP1-HY5 interaction, and nuclear accumulation of COP1. Interestingly, prolonged light exposure reduces the sumoylation level of COP1, and COP1 mediates the ubiquitination and degradation of SIZ1. These regulatory mechanisms may maintain the homeostasis of COP1 activity, ensuing proper photomorphogenic development in changing light environment. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  3. Improvement In The COP Of Thermoelectric Cooler

    Directory of Open Access Journals (Sweden)

    Jatin Patel

    2015-08-01

    Full Text Available This paper described the study for heat transfer through thermoelectric cooler TEC by use of multistage thermoelectric module. To satisfy the heat dissipation of modern electronic element thermal designers have to increase fin area and fan speed to improve its cooling capacity. However the increase of fin area is restricted by the space. Besides the increase of fan speed would induce noise which damages human health. So air cooling by fan is hardly to meet the requirement of modern electronic component. Recently thermoelectric cooler TEC is applied to electronic cooling with the advantages of small size quietness and reliability. A typical thermoelectric cooler consists of p-type and n-type semiconductor pellets connected electrically in series and sandwiched between two ceramic substrates. Whenever direct current passes through the circuit it causes temperature differential between TEC sides. As a result one face of TEC which is called cold side will be cooled while its opposite face which is called hot side is simultaneously heated. The main problem over the use of TEC is the limited COP and its thermal performance. But these can be eliminated by use of multistage thermoelectric cooler.

  4. Special COP 21 - Stakes and actors

    International Nuclear Information System (INIS)

    Chauveau, Loic; Dupain, Julien; Descamps, Olivier; Blosseville, Thomas; Connors, Anne; Canto, Albane; Robischon, Christian; Boedec, Morgan; Tubiana, Fabian; Bomstein, Dominique

    2015-01-01

    A first set of article comments and discusses the various stakes and challenges of the 21. Conference of Parties (COP 21): the negotiation process which resulted in a synthesis which is to be signed by 95 States in Paris, the elaboration of an Agenda of solutions with the commitment of enterprises and local authorities, the issue of international financing as some promises remained not kept for the support to adaptation of developing countries. A second set of articles addresses the involved actors and their technological or economic challenges: the needed evolution of energy (electricity, heat, gas, fuel) producers away from fossil energies to reduce greenhouse gas emissions, the strategy of the French company Engie in the field of photovoltaic, wind and more generally renewable energies, innovating trends of decentralisation of energy production (offshore wind energy, hydrogen, plasma torch, flexible photovoltaic arrays, the wind tree, the floating wind turbine, new technologies for solar arrays), the perspectives for industrial sectors concerned by energy transition (with the example of Schneider Electric), emerging technologies (oil lamp, new boilers, desalination equipment, storage of wind energy, co-generation), developments and perspectives in the transport sector (example of Renault, new technologies for hybrid propulsion, bio-refineries, reduction of fuel consumption, hybrid aircraft, and heat management in railways) and in the building sector (new standards and applications, new building materials). A last article outlines the threat that climate can be for profitability and the taking of the carbon risk into account by the insurance and financial sectors

  5. EER, COP, and the Second Law Efficiency for Air Conditioners

    Science.gov (United States)

    Leff, Harvey S.; Teeters, William D.

    1978-01-01

    Describes the relationship existing between coefficient of performance (COP) and energy efficiency ratio (EER) in air conditioning units and introduces new efficiency parameters measured relative to the energy extracted from the primary energy source. (SL)

  6. COPS model estimates of LLEA availability near selected reactor sites

    International Nuclear Information System (INIS)

    Berkbigler, K.P.

    1979-11-01

    The COPS computer model has been used to estimate local law enforcement agency (LLEA) officer availability in the neighborhood of selected nuclear reactor sites. The results of these analyses are presented both in graphic and tabular form in this report

  7. From COP21 to COP22: how to win the climate struggle?

    International Nuclear Information System (INIS)

    Mathieu, Carole

    2016-10-01

    In this publication, the author first proposes a discussion on climate policies after the relative success of the COP21 in Paris which opened the way to new commitments for mitigation of climate changes and adaptation to them. She outlines that these policies can be characterized by a declared voluntarism for some of them, but also by a lack of global consistency. She proposes an overview of the diversity of measures aimed at emission reduction, outlines the weight of the uncertainty due to elections in the USA, discusses the issue of climate compatibility of public decisions, and notices the still high tension between economic development and climate protection. In a second part, within the perspective of the COP22, she highlights and discusses the lack of commitment for low carbon solutions. She finally discusses perspectives for a better and more dynamic international cooperation through a mutual control, an attention given to the financing issue, and a common approach to the development of tools for a low-carbon transition

  8. Gait COP trajectory of left side hip-dislocation and scoliotic patient using ankle-foot orthoses

    Science.gov (United States)

    Chong, Albert K.; Alrikabi, Redha; Milburn, Peter

    2017-07-01

    Plantar pressure-sensing mats and insole plantar sensor pads are ideal low-cost alternatives to force plates for capturing plantar COP excursion during gait. The acquired COP traces, in the form of pedobarographic images are favored by many clinicians and allied health professionals for evaluation of foot loading and balance in relation to foot biomechanics, foot injury, foot deformation, and foot ulceration. Researchers have recommended the use of COP trace for the biomechanical study of the deformed foot and lower-limb to improve orthosis design and testing. A correctly designed orthoses improves mobility and reduces pain in the foot, lower limb and lower spine region during gait. The research was carried out to evaluate the performance of two types of orthosis, namely: a custom-molded orthosis and an over-the-counter molded orthosis to determine the quality of gait of an adult scoliotic patient. COP trace patterns were compared with those of a healthy adult and showed the design of the custom-molded orthosis resulted in an improved quality of movements and provided enhanced stability for the deformed left foot during gait.

  9. Applications of RFID technology in dismounted soldier solution systems – study of mCOP system capabilities

    Directory of Open Access Journals (Sweden)

    Chmielewski Mariusz

    2016-01-01

    Full Text Available This paper discusses application of RFID technology in Dismounted Soldier Solutions gathered from the development and demonstration of mCOP platform. The software has been developed to elaborate Network Enabled Capabilities in tactical environments. Presented research was a part of demonstration prepared for the European Defence Agency. The main aim of the tool is the delivery of command support capabilities utilizing data fusion and integration mechanisms implemented in heterogeneous military mobile networks. Application of military integration standards such as JC3IEDM, NFFI and TSO supports interoperability with BMS class systems. Utilisation of RFID technology in mCOP software has several purposes, mainly used for process automation of authorisation and personal identification. Indirectly such functionalities can be used for implementation of UAV supported - Blue Force Tracking and IFF services. This research elaborates a set of implemented ideas for such solutions. Developed system serves as a multi-level and multi-platform command and control system supporting military and crisis operations. A crucial part of the system - mCOP, the handheld application for tactical level commanders, serves as personal toolkit for location monitoring and combat situation distribution and management. The tool delivers a set of tailored functionalities supporting commander’s situation awareness and decision making process. The mCOP hosting device equipped with RFID delivers also means of tactical , emergency, micro network communication.

  10. People's Rebuplic of China's Performance in the UNFCCC : A Comparison of China's Position at COP15 Copenhagen to COP22 Marrakech

    OpenAIRE

    Sommerholt, Lovisa

    2017-01-01

    Since the US election in the fall of 2016, China have been looked towards to fill a leadership position in climate change negotiations. This essay focuses on determining China's efficiency in the COP15 and COP22 negotiations in establishing its ambitions and policy objectives. The results show that China was very effective in achieveing their policy aims both at COP15 and COP22 even if the negotiations had different aims. The overall performance of China has affected the COP outcomes and help...

  11. COP21: to save negotiations or to save the climate?

    International Nuclear Information System (INIS)

    Fremeaux, Alexis; Faure, Elisa; Guillou, Antoine

    2015-01-01

    This note proposes an overview of the main issues which could render an agreement possible at the end of the Paris COP21, and makes some proposals on principles which should be mentioned in the agreement to create a future strong foundation, as well as on tools and measures which could be implemented thereafter. The authors first discuss the content and results of the previous COPs, and comment the negotiation process between Copenhagen and Paris to outline the main challenges and stakes to reach of common agreement. They address the main issues of the COP21 negotiations: mobilisation of 100 billions dollars per year to help emerging countries in reaching a low carbon development mode and to adapt to climate change, how to urgently orient private investments towards a low carbon economy, to base on standards and transparency as two main action levers in case of absence of agreement on carbon price, and definition of needed more ambitious objectives

  12. 50 CFR 23.86 - How can I obtain information on a CoP?

    Science.gov (United States)

    2010-10-01

    ... FAUNA AND FLORA (CITES) CITES Administration § 23.86 How can I obtain information on a CoP? As we receive information on an upcoming CoP from the CITES Secretariat, we will notify the public either...

  13. COP9 signalosome: a provider of DNA building blocks

    DEFF Research Database (Denmark)

    Nielsen, Olaf

    2003-01-01

    In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus...

  14. 7 CFR 457.126 - Popcorn cop isurance povisions.

    Science.gov (United States)

    2010-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.126 Popcorn cop isurance... permit mechanical cultivation, unless otherwise provided by the Special Provisions, actuarial documents... policy unless the Special Provisions provide different price elections by type, in which case you may...

  15. In situ electrodeposition of CoP nanoparticles on carbon nanomaterial doped polyphenylene sulfide flexible electrode for electrochemical hydrogen evolution

    Science.gov (United States)

    Wang, Tingxia; Jiang, Yimin; Zhou, Yaxin; Du, Yongling; Wang, Chunming

    2018-06-01

    Active and durable electrocatalyst for hydrogen evolution reaction (HER) is pivotal to generate molecular hydrogen more energy-efficient, but directly grafting electrocatalyst on electrode material by a single-step method without compromising the catalytic activity and stability remains a challenge. Herein, an intriguing electrode, reduced graphene oxide modified carbon nanotube/reduced graphene oxide/polyphenylene sulfide (RGO-CNT/RGO/PPS) film, is used to replace conventional electrodes. In situ electrodeposition is proposed to fabricate CoP on the RGO-CNT/RGO/PPS (CoP-RGO-CNT/RGO/PPS) electrode and achieves a favorably electrical contact between CoP nanoparticles and RGO-CNT/RGO/PPS electrode due to without any polymer binder. Additionally, the coupling of different electrodeposition stages with scanning electron microscope (SEM) can investigate the nanostructure evolution of CoP nanoparticles, which gives valuable insights into the optimized electrodeposition cycles. The rational integration of RGO onto CNT/RGO/PPS film is an effective approach for enhancing its intrinsic electrical conductivity and favoring the formation of a high density of dispersive CoP nanoparticles. The CoP-RGO-CNT/RGO/PPS film has shown outstanding HER electrocatalytic behaviors performed a current density of 10 mA cm-2 at a relatively low overpotential of 160 mV with a Tafel slope of 60 mV dec-1 in acidic medium, which can be mainly attributed to the synergistic effect between optimized morphology and accelerated kinetics. Additionally, this film electrocatalyst exhibits a good HER activity and stability under both neutral and basic conditions.

  16. Study on Relative COP Changes with Increasing Heat Input Temperatures of Double Effect Steam Absorption Chillers

    Directory of Open Access Journals (Sweden)

    Abd Majid Mohd Amin

    2016-01-01

    Full Text Available Absorption chillers at cogeneration plants generate chilled water using steam supplied by heat recovery steam generators. The chillers are mainly of double effect type. The COP of double effect varies from 0.7 to 1.2 depending on operation and maintenance practices of the chillers. Heat input to the chillers during operations could have impact on the COP of the chillers. This study is on relative COP changes with increasing the heat input temperatures for a steam absorption chiller at a gas fueled cogeneration plant. Reversible COP analysis and zero order model were used for evaluating COP of the chiller for 118 days operation period. Results indicate increasing COP trends for both the reversible COP and zero model COP. Although the zero model COP are within the range of double effect absorption chiller, it is not so for the actual COP. The actual COP is below the range of normal double effect COP. It is recommended that economic replacement analysis to be undertaken to assess the feasibility either to repair or replace the existing absorption chiller.

  17. IRR (Inter-Rater Reliability) of a COP (Classroom Observation Protocol)--A Critical Appraisal

    Science.gov (United States)

    Rui, Ning; Feldman, Jill M.

    2012-01-01

    Notwithstanding broad utility of COPs (classroom observation protocols), there has been limited documentation of the psychometric properties of even the most popular COPs. This study attempted to fill this void by closely examining the item and domain-level IRR (inter-rater reliability) of a COP that was used in a federally funded striving readers…

  18. 77 FR 68149 - Agency Information Collection Activities; Proposed New Collection; Comments Requested: COPS...

    Science.gov (United States)

    2012-11-15

    ... Collection; Comments Requested: COPS Comparative Assessment of Cost Reduction by Agencies Survey ACTION: 60... Collection: Proposed new collection; comments requested. (2) Title of the Form/Collection: COPS Comparative... brief abstract: Law enforcement agencies and other public and private entities that apply for COPS...

  19. Streptococcus mutans copper chaperone, CopZ, is critical for biofilm formation and competitiveness.

    Science.gov (United States)

    Garcia, S S; Du, Q; Wu, H

    2016-12-01

    The oral cavity is a dynamic environment characterized by hundreds of bacterial species, saliva, and an influx of nutrients and metal ions such as copper. Although there is a physiologic level of copper in the saliva, the oral cavity is often challenged with an influx of copper ions. At high concentrations copper is toxic and must therefore be strictly regulated by pathogens for them to persist and cause disease. The cariogenic pathogen Streptococcus mutans manages excess copper using the copYAZ operon that encodes a negative DNA-binding repressor (CopY), the P1-ATPase copper exporter (CopA), and the copper chaperone (CopZ). These hypothetical roles of the copYAZ operon in regulation and copper transport to receptors led us to investigate their contribution to S. mutans virulence. Mutants defective in the copper chaperone CopZ, but not CopY or CopA, were impaired in biofilm formation and competitiveness against commensal streptococci. Characterization of the CopZ mutant biofilm revealed a decreased secretion of glucosyltransferases and reduced expression of mutacin genes. These data suggest that the function of copZ on biofilm and competitiveness is independent of copper resistance and CopZ is a global regulator for biofilm and other virulence factors. Further characterization of CopZ may lead to the identification of new biofilm pathways. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. 30 CFR 285.628 - How will MMS process my COP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS process my COP? 285.628 Section... Requirements Contents of the Construction and Operations Plan § 285.628 How will MMS process my COP? (a) The MMS will review your submitted COP, and the information provided pursuant to § 285.627, to determine...

  1. 30 CFR 285.620 - What is a Construction and Operations Plan (COP)?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is a Construction and Operations Plan (COP... Information Requirements Construction and Operations Plan for Commercial Leases § 285.620 What is a Construction and Operations Plan (COP)? The COP describes your construction, operations, and conceptual...

  2. Stabilization

    Directory of Open Access Journals (Sweden)

    Muhammad H. Al-Malack

    2016-07-01

    Full Text Available Fuel oil flyash (FFA produced in power and water desalination plants firing crude oils in the Kingdom of Saudi Arabia is being disposed in landfills, which increases the burden on the environment, therefore, FFA utilization must be encouraged. In the current research, the effect of adding FFA on the engineering properties of two indigenous soils, namely sand and marl, was investigated. FFA was added at concentrations of 5%, 10% and 15% to both soils with and without the addition of Portland cement. Mixtures of the stabilized soils were thoroughly evaluated using compaction, California Bearing Ratio (CBR, unconfined compressive strength (USC and durability tests. Results of these tests indicated that stabilized sand mixtures could not attain the ACI strength requirements. However, marl was found to satisfy the ACI strength requirement when only 5% of FFA was added together with 5% of cement. When the FFA was increased to 10% and 15%, the mixture’s strength was found to decrease to values below the ACI requirements. Results of the Toxicity Characteristics Leaching Procedure (TCLP, which was performed on samples that passed the ACI requirements, indicated that FFA must be cautiously used in soil stabilization.

  3. Magnetosheath plasma stability and ULF wave occurrence as a function of location in the magnetosheath and upstream bow shock parameters

    Science.gov (United States)

    Soucek, Jan; Escoubet, C. Philippe; Grison, Benjamin

    2015-04-01

    We present the results of a statistical study of the distribution of mirror and Alfvén-ion cyclotron (AIC) waves in the magnetosheath together with plasma parameters important for the stability of ULF waves, specifically ion temperature anisotropy and ion beta. Magnetosheath crossings registered by Cluster spacecraft over the course of 2 years served as a basis for the statistics. For each observation we used bow shock, magnetopause, and magnetosheath flow models to identify the relative position of the spacecraft with respect to magnetosheath boundaries and local properties of the upstream shock crossing. A strong dependence of both plasma parameters and mirror/AIC wave occurrence on upstream ΘBn and MA is identified. We analyzed a joint dependence of the same parameters on ΘBn and fractional distance between shock and magnetopause, zenith angle, and length of the flow line. Finally, the occurrence of mirror and AIC modes was compared against the respective instability thresholds. We noted that AIC waves occurred nearly exclusively under mirror stable conditions. This is interpreted in terms of different characters of nonlinear saturation of the two modes.

  4. Report the Africa renewable energy initiative launched at COP21

    International Nuclear Information System (INIS)

    Royal, Segolene

    2016-09-01

    Segolene Royal, President of COP21, presents in this report the specific renewable energy projects to be embarked on in Africa without delay. On the basis of the COP21 President's visits to 17 African countries, her discussions with African leaders and analysis by groups of experts, a list of 240 projects accounting for more than 45 GW of renewable capacity is being made public: 13 geothermal energy projects: 7 GW; 58 hydroelectricity projects: 20 GW; 62 solar energy projects: 6 GW; 16 wind energy projects: 5 GW; 35 projects combining more than one technology: 1 GW; 4 national strategies (solar and wind energy): 8 GW. Launched by African heads of state on 1 December 2015 in the presence of French President Francois Hollande, the Africa Renewable Energy Initiative aims to increase the continent's installed capacity of renewable energy by 10 GW by 2020 and 300 GW by 2030. During COP21. To achieve this goal, Segolene Royal has pledged to facilitate the implementation of the initiative throughout the French COP21 presidency. The report proposes a review of the energy situation in Africa and sets out 10 recommendations to speed up the deployment of renewable energy on the continent: 1. To identify a list of priority projects to implement by 2020, and projects to begin before and during COP22; 2. To bring the partners together around each project to share out responsibilities; 3. To initiate dialogue with the private sector about the initiative and projects; 4. To strengthen participatory citizenship regarding energy; 5. To involve African women in renewable energy; 6. To draw on the International Solar Alliance, launched at COP21, and the Global Geothermal Alliance; 7. To put in place innovative financial instruments, such as loan-grant blending; 8. To allow for climate change in the projects; 9. To strengthen the independent body responsible for implementing the initiative, hosted and supported by the African Development Bank; 10. To finalize a map of existing

  5. The game of cops and robbers on graphs

    CERN Document Server

    Bonato, Anthony

    2011-01-01

    This book is the first and only one of its kind on the topic of Cops and Robbers games, and more generally, on the field of vertex pursuit games on graphs. The book is written in a lively and highly readable fashion, which should appeal to both senior undergraduates and experts in the field (and everyone in between). One of the main goals of the book is to bring together the key results in the field; as such, it presents structural, probabilistic, and algorithmic results on Cops and Robbers games. Several recent and new results are discussed, along with a comprehensive set of references. The book is suitable for self-study or as a textbook, owing in part to the over 200 exercises. The reader will gain insight into all the main directions of research in the field and will be exposed to a number of open problems.

  6. How to distribute the carbon budget at the COP21?

    International Nuclear Information System (INIS)

    Laurent, Eloi

    2015-09-01

    This article reviews different fairness criteria for the measuring of CO 2 emissions by the main countries responsible of climate change in order to fairly distribute the carbon budget during the Paris negotiation of the COP21. It shows that it is possible to use reliable data to build up a relatively simple and fair climatic hybrid criterion which takes consumption emissions, historic responsibility, population, and economic development level into account

  7. MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-01-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

  8. Working Together but in Opposition: An Examination of the "Good-Cop/Bad-Cop" Negotiating Team Tactic.

    Science.gov (United States)

    Brodt; Tuchinsky

    2000-03-01

    Unlike solo negotiators, members of negotiating teams may for strategic reasons choose to play different roles; the familiar "good cop/bad cop" distributive bargaining tactic is one example of role differentiation designed to enhance a team's success at the bargaining table. In two empirical studies about a hypothetical three-person work group, we examined the cognitive processes underlying this tactic using a social-cognitive decision model (Brodt & Duncan, 1998) that conceptualizes the negotiators' decision tasks and persuasion processes. Results generally supported the model except for an intriguing asymmetry depending on a person's initial inclination (accepting, rejecting). This research extends findings on the tactic and on contrast effects (Cialdini, 1984) and supports the model's usefulness as an approximate representation of negotiator cognition. Copyright 2000 Academic Press.

  9. Cop-like operon: Structure and organization in species of the Lactobacillale order

    Directory of Open Access Journals (Sweden)

    ANGÉLICA REYES

    2006-01-01

    Full Text Available Copper is an essential and toxic trace metal for bacteria and, therefore, must be tightly regulated in the cell. Enterococcus hirae is a broadly studied model for copper homeostasis. The intracellular copper levels in E. hirae are regulated by the cop operon, which is formed by four genes: copA and copB that encode ATPases for influx and efflux of copper, respectively; copZ that encodes a copper chaperone; and copY, a copper responsive repressor. Since the complete genome sequence for E. hirae is not available, it is possible that other genes may encode proteins involved in copper homeostasis. Here, we identified a cop-like operon in nine species of Lactobacillale order with a known genome sequence. All of them always encoded a CopY-like repressor and a copper ATPase. The alignment of the cop-like operon promoter region revealed two CopY binding sites, one of which was conserved in all strains, and the second was only present in species of Streptococcus genus and L. johnsonii. Additional proteins associated to copper metabolism, CutC and Cupredoxin, also were detected. This study allowed for the description of the structure and organization of the cop operon and discussion of a phylogenetic hypothesis based on the differences observed in this operon's organization and its regulation in Lactobacillale order.

  10. Ademe et Vous. International Newsletter No. 35, December 2015. COP21: one objective, four pillars

    International Nuclear Information System (INIS)

    Martin, Valerie; Seguin-Jacques, Catherine; Tappero, Denis

    2015-12-01

    Content: - COP21: one objective, four pillars: With COP21 providing a platform for intergovernmental negotiations, ADEME is actively working alongside with non-state actors to foster an environment conducive to success. - ADEME, a stakeholder of COP21: ADEME has been particularly proactive when it comes to mobilising non-state actors in the context of COP21, and has made the most of its presence at Le Bourget to announce a number of new initiatives covering a number of the 12 themes that make up the Lima-Paris Action Agenda. - Innovation exhibited at COP21: Giving the public an opportunity to be within reach of the world of tomorrow: This is the aim of the Innov'Climat exhibition, initiated by ADEME back in July and developed for COP21

  11. CopM is a novel copper-binding protein involved in copper resistance in Synechocystis sp. PCC 6803

    Science.gov (United States)

    Giner-Lamia, Joaquín; López-Maury, Luis; Florencio, Francisco J

    2015-01-01

    Copper resistance system in the cyanobacterium Synechocystis sp. PCC 6803 comprises two operons, copMRS and copBAC, which are expressed in response to copper in the media. copBAC codes for a heavy-metal efflux–resistance nodulation and division (HME-RND) system, while copMRS codes for a protein of unknown function, CopM, and a two-component system CopRS, which controls the expression of these two operons. Here, we report that CopM is a periplasmic protein able to bind Cu(I) with high affinity (KD ∼3 × 10−16). Mutants lacking copM showed a sensitive copper phenotype similar to mutants affected in copB, but lower than mutants of the two-component system CopRS, suggesting that CopBAC and CopM constitute two independent resistance mechanisms. Moreover, constitutive expression of copM is able to partially suppress the copper sensitivity of the copR mutant strain, pointing out that CopM per se is able to confer copper resistance. Furthermore, constitutive expression of copM was able to reduce total cellular copper content of the copR mutant to the levels determined in the wild-type (WT) strain. Finally, CopM was localized not only in the periplasm but also in the extracellular space, suggesting that CopM can also prevent copper accumulation probably by direct copper binding outside the cell. PMID:25545960

  12. CoP Sensing Framework on Web-Based Environment

    Science.gov (United States)

    Mustapha, S. M. F. D. Syed

    The Web technologies and Web applications have shown similar high growth rate in terms of daily usages and user acceptance. The Web applications have not only penetrated in the traditional domains such as education and business but have also encroached into areas such as politics, social, lifestyle, and culture. The emergence of Web technologies has enabled Web access even to the person on the move through PDAs or mobile phones that are connected using Wi-Fi, HSDPA, or other communication protocols. These two phenomena are the inducement factors toward the need of building Web-based systems as the supporting tools in fulfilling many mundane activities. In doing this, one of the many focuses in research has been to look at the implementation challenges in building Web-based support systems in different types of environment. This chapter describes the implementation issues in building the community learning framework that can be supported on the Web-based platform. The Community of Practice (CoP) has been chosen as the community learning theory to be the case study and analysis as it challenges the creativity of the architectural design of the Web system in order to capture the presence of learning activities. The details of this chapter describe the characteristics of the CoP to understand the inherent intricacies in modeling in the Web-based environment, the evidences of CoP that need to be traced automatically in a slick manner such that the evidence-capturing process is unobtrusive, and the technologies needed to embrace a full adoption of Web-based support system for the community learning framework.

  13. Ultrascalable Techniques Applied to the Global Intelligence Community Information Awareness Common Operating Picture (IA COP)

    National Research Council Canada - National Science Library

    Valdes, Alfonso; Kadte, Jim

    2005-01-01

    The focus of this research is to develop detection, correlation, and representation approaches to address the needs of the Intelligence Community Information Awareness Common Operating Picture (IA COP...

  14. Almost all k-cop-win graphs contain a dominating set of cardinality k

    OpenAIRE

    Pralat, Pawel

    2013-01-01

    We consider $k$-cop-win graphs in the binomial random graph $G(n,1/2).$ It is known that almost all cop-win graphs contain a universal vertex. We generalize this result and prove that for every $k \\in N$, almost all $k$-cop-win graphs contain a dominating set of cardinality $k$. From this it follows that the asymptotic number of labelled $k$-cop-win graphs of order $n$ is equal to $(1+o(1)) (1-2^{-k})^{-k} {n \\choose k} 2^{n^2/2 - (1/2-\\log_2(1-2^{-k})) n}$.

  15. The SafeCOP ECSEL Project: Safe Cooperating Cyber-Physical Systems Using Wireless Communication

    DEFF Research Database (Denmark)

    Pop, Paul; Scholle, Detlef; Hansson, Hans

    2016-01-01

    This paper presents an overview of the ECSEL project entitled "Safe Cooperating Cyber-Physical Systems using Wireless Communication" (SafeCOP), which runs during the period 2016 -- 2019. SafeCOP targets safety-related Cooperating Cyber-Physical Systems (CO-CPS) characterised by use of wireless...... detection of abnormal behaviour, triggering if needed a safe degraded mode. SafeCOP will also develop methods and tools, which will be used to produce safety assurance evidence needed to certify cooperative functions. SafeCOP will extend current wireless technologies to ensure safe and secure cooperation...

  16. Can vibratory feedback be used to improve postural stability in persons with transtibial limb loss?

    Science.gov (United States)

    Rusaw, David; Hagberg, Kerstin; Nolan, Lee; Ramstrand, Nerrolyn

    2012-01-01

    The use of vibration as a feedback modality to convey motion of the body has been shown to improve measures of postural stability in some groups of patients. Because individuals using transtibial prostheses lack sensation distal to the amputation, vibratory feedback could possibly be used to improve their postural stability. The current investigation provided transtibial prosthesis users (n = 24, mean age 48 yr) with vibratory feedback proportional to the signal received from force transducers located under the prosthetic foot. Postural stability was evaluated by measuring center of pressure (CoP) movement, limits of stability, and rhythmic weight shift while participants stood on a force platform capable of rotations in the pitch plane (toes up/toes down). The results showed that the vibratory feedback increased the mediolateral displacement amplitude of CoP in standing balance and reduced the response time to rapid voluntary movements of the center of gravity. The results suggest that the use of vibratory feedback in an experimental setting leads to improvements in fast open-loop mechanisms of postural control in transtibial prosthesis users.

  17. Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian function.

    Directory of Open Access Journals (Sweden)

    Zhipeng Zhou

    Full Text Available The COP9 signalosome (CSN is a highly conserved multifunctional complex that has two major biochemical roles: cleaving NEDD8 from cullin proteins and maintaining the stability of CRL components. We used mutation analysis to confirm that the JAMM domain of the CSN-5 subunit is responsible for NEDD8 cleavage from cullin proteins in Neurospora crassa. Point mutations of key residues in the metal-binding motif (EX(nHXHX(10D of the CSN-5 JAMM domain disrupted CSN deneddylation activity without interfering with assembly of the CSN complex or interactions between CSN and cullin proteins. Surprisingly, CSN-5 with a mutated JAMM domain partially rescued the phenotypic defects observed in a csn-5 mutant. We found that, even without its deneddylation activity, the CSN can partially maintain the stability of the SCF(FWD-1 complex and partially restore the degradation of the circadian clock protein FREQUENCY (FRQ in vivo. Furthermore, we showed that CSN containing mutant CSN-5 efficiently prevents degradation of the substrate receptors of CRLs. Finally, we found that deletion of the CAND1 ortholog in N. crassa had little effect on the conidiation circadian rhythm. Our results suggest that CSN integrity plays major roles in hyphal growth, conidial development, and circadian function in N. crassa.

  18. 76 FR 35683 - Medicare Program; Conditions of Participation (CoPs) for Community Mental Health Centers

    Science.gov (United States)

    2011-06-17

    ... Community Mental Health Centers; Proposed Rule #0;#0;Federal Register / Vol. 76 , No. 117 / Friday June 17... (CoPs) for Community Mental Health Centers AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS... participation (CoPs) that community mental health centers (CMHCs) would have to meet in order to participate in...

  19. 78 FR 2692 - Agency Information Collection Activities; Proposed New Collection; Comments Requested: COPS...

    Science.gov (United States)

    2013-01-14

    ... Collection; Comments Requested: COPS Comparative Assessment of Cost Reduction by Agencies Survey ACTION: 30...; comments requested. (2) Title of the Form/Collection: COPS Comparative Assessment of Cost Reduction by...) Affected public who will be asked or required to respond, as well as a brief abstract: Law enforcement...

  20. Impacts of CoP on Organizational Socialization in the Early Career

    Science.gov (United States)

    Chang, Joohee; Chang, Wonsup; Jacobs, Ronald L.

    2008-01-01

    This paper focuses on the relationship between participation in communities of practice (CoP) and outcomes of organizational socialization (learning and adjustment) early in the career. Results from responses of employees in a Korean IT company show that participation in CoP is more strongly related to adjustment (job satisfaction, organizational…

  1. 20 CFR 10.216 - How is the pay rate for COP calculated?

    Science.gov (United States)

    2010-04-01

    ... for COP purposes is equal to the employee's regular “weekly” pay (the average of the weekly pay over... occurred during the 45-day period are to be reflected in the weekly pay determination. (b) The weekly pay... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How is the pay rate for COP calculated? 10...

  2. Investing for a low carbon economy. Special issue COP21

    International Nuclear Information System (INIS)

    Guez, Herve; Basselier, Clotilde; Bennani, Zineb; Coeslier, Manuel; Dufour, Mathilde; Dunand-Chatellet, Lea; Guez, Herve; Lauverjat Celine; Ostiari, Emmanuelle; Smia, Ladislas; Bonnin, Marguerite; Briand, Marc; Favier, Julien; Finidori, Esther; Wigley, Chris; Dobie, Jacqueline; Mary Ellis, Susannah; Kiernan, Shannon; Lefer, Elizabeth; Perrin, Elsa; Treadwell, Christopher; Zerner, Rachel

    2015-11-01

    Mirova, an asset management firm dedicated to responsible investment, has published today Investing in a low-carbon economy, a guide for investors to become COP21 compliant. Mirova's study provides an in-depth analysis highlighting the challenges of climate change and presents methods for investors to effectively measure their carbon footprint. Mirova offers a unique range of investment solutions promoting energy transition across all asset classes. COP21: mobilising private investors is a necessity To maintain the economy in a '2 degree' trajectory, it is vital to redirect savings towards companies and projects promoting energy transition. Philippe Zaouati, Head of Mirova explains: 'The energy transition can only succeed if we manage to mobilise private investors' savings. The success of COP21 therefore also depends on the ability of asset management firms to propose solutions in response to the climate challenge, whilst delivering the returns expected by investors'. Accurately measuring your carbon footprint. In response to growing demands on investors to make greener investments, Mirova, in partnership with the leading carbon strategy specialist consultant Carbone 4, has developed an innovative methodology to measure the carbon footprint of an investment portfolio. This decision-making tool assesses a company's contribution to the reduction of global greenhouse gas emissions (GGE). Measuring the overall impact of a business on the environment is an essential step towards acting against global warming. Assessing the carbon footprint is therefore an indispensable stage in the construction of portfolios contributing to energy transition. Low-carbon investments across all asset classes In order to redirect capital towards investments promoting energy transition, Mirova is proposing solutions involving all asset classes: - Renewable energy infrastructures: 100% low carbon allocation For more than 10 years now, Mirova has provided European institutions with access to

  3. Multiscale GPS tomography during COPS: validation and applications

    Science.gov (United States)

    Champollion, Cédric; Flamant, Cyrille; Masson, Frédéric; Gégout, Pascal; Boniface, Karen; Richard, Evelyne

    2010-05-01

    Accurate 3D description of the water vapour field is of interest for process studies such as convection initiation. None of the current techniques (LIDAR, satellite, radio soundings, GPS) can provide an all weather continuous 3D field of moisture. The combination of GPS tomography with radio-soundings (and/or LIDAR) has been used for such process studies using both advantages of vertically resolved soundings and high temporal density of GPS measurements. GPS tomography has been used at short scale (10 km horizontal resolution but in a 50 km² area) for process studies such as the ESCOMPTE experiment (Bastin et al., 2005) and at larger scale (50 km horizontal resolution) during IHOP_2002. But no extensive statistical validation has been done so far. The overarching goal of the COPS field experiment is to advance the quality of forecasts of orographically induced convective precipitation by four-dimensional observations and modeling of its life cycle for identifying the physical and chemical processes responsible for deficiencies in QPF over low-mountain regions. During the COPS field experiment, a GPS network of about 100 GPS stations has been continuously operating during three months in an area of 500 km² in the East of France (Vosges Mountains) and West of Germany (Black Forest). If the mean spacing between the GPS is about 50 km, an East-West GPS profile with a density of about 10 km is dedicated to high resolution tomography. One major goal of the GPS COPS experiment is to validate the GPS tomography with different spatial resolutions. Validation is based on additional radio-soundings and airborne / ground-based LIDAR measurement. The number and the high quality of vertically resolved water vapor observations give an unique data set for GPS tomography validation. Numerous tests have been done on real data to show the type water vapor structures that can be imaging by GPS tomography depending of the assimilation of additional data (radio soundings), the

  4. Effect of two Backpack Designs on Cop Displacement and Plantar Force Distribution in Children during Upright Stance

    Directory of Open Access Journals (Sweden)

    Mastalerz Andrzej

    2016-09-01

    Full Text Available Introduction. Many studies have compared different backpack designs and their influence on the carrier; however, no data referring to school students aged 7-8 years are currently available. Therefore, the aim of the research was to assess the influence of backpack design on centre of pressure (COP displacement and plantar force distribution in children during an upright stance. Material and methods. Nineteen school students (9 males and 10 females volunteered for the study. Two Polish backpacks intended for school use were evaluated: backpack A, which had two main compartments, and backpack B, which had one main compartment. The backpack load was composed of books, binders, and regular school equipment. During the measurements, the subjects were asked to look ahead with the head straight and arms at the sides in a comfortable position and to stand barefoot on the F-Scan® sensors (Tekscan, F-Scan® attached to the force platform (Kistler, carrying a load corresponding to 10% of their body mass. Results. The study found insignificant differences between the two backpack designs. Moreover, COP parameters increased significantly during an upright stance while carrying backpack B in comparison to the empty backpack condition. Additionally, we observed significantly higher values of plantar force distribution in the heel region for the condition without load and insignificantly higher ones for carrying backpack A. Conclusions. The results of the current study suggest that the differences between the two backpack designs are too marginal to be detected through COP displacement. Disturbances in plantar force distribution suggest a lack of posture control and a lower stability of the standing position with a backpack, but these disturbances were significant only when the backpack with one main compartment was used.

  5. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome

    Directory of Open Access Journals (Sweden)

    Shelly Rozen

    2015-10-01

    Full Text Available The highly conserved COP9 signalosome (CSN complex is a key regulator of all cullin-RING-ubiquitin ligases (CRLs, the largest family of E3 ubiquitin ligases. Until now, it was accepted that the CSN is composed of eight canonical components. Here, we report the discovery of an additional integral and stoichiometric subunit that had thus far evaded detection, and we named it CSNAP (CSN acidic protein. We show that CSNAP binds CSN3, CSN5, and CSN6, and its incorporation into the CSN complex is mediated through the C-terminal region involving conserved aromatic residues. Moreover, depletion of this small protein leads to reduced proliferation and a flattened and enlarged morphology. Finally, on the basis of sequence and structural properties shared by both CSNAP and DSS1, a component of the related 19S lid proteasome complex, we propose that CSNAP, the ninth CSN subunit, is the missing paralogous subunit of DSS1.

  6. 30 CFR 285.902 - What are the general requirements for decommissioning for facilities authorized under my SAP, COP...

    Science.gov (United States)

    2010-07-01

    ... decommissioning for facilities authorized under my SAP, COP, or GAP? 285.902 Section 285.902 Mineral Resources... SAP, COP, or GAP? (a) Except as otherwise authorized by MMS under § 285.909, within 2 years following... under your SAP, COP, or GAP, you must submit a decommissioning application and receive approval from the...

  7. Mapping the surface of MNKr2 and CopZ - identification of residues critical for metallotransfer

    International Nuclear Information System (INIS)

    Jones, C.E.; Cobine, P.A.; Dameron, C.T.

    2001-01-01

    Full text: Cells utilise a network of proteins that include CPx-type ATPases and metallochaperones to balance intracellular copper concentration. The Menkes ATPase has six N-terminal domains which bind Cu(I) and are critical for ATPase function. The NMR solution structure of the second domain (MNKr2) shows that the structure adopts an 'open-faced β-sandwich' fold, in which two α-helices lie over a single four stranded β-sheet. The global fold is identical to the bacterial copper chaperone CopZ MNKr2 is unable to substitute for CopZ in copper transfer to the cop operon represser, CopY. To investigate how structure affects function we have analysed the surface features of MNKr2 and CopZ Despite having the same global fold, MNKr2 and CopZ have contrasting electrostatic surfaces, which may partially explain the inability of MNKr2 to transfer copper to CopY

  8. Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices.

    Science.gov (United States)

    Wan, Alwin M D; Moore, Thomas A; Young, Edmond W K

    2017-01-17

    Thermoplastic microfluidic devices offer many advantages over those made from silicone elastomers, but bonding procedures must be developed for each thermoplastic of interest. Solvent bonding is a simple and versatile method that can be used to fabricate devices from a variety of plastics. An appropriate solvent is added between two device layers to be bonded, and heat and pressure are applied to the device to facilitate the bonding. By using an appropriate combination of solvent, plastic, heat, and pressure, the device can be sealed with a high quality bond, characterized as having high bond coverage, bond strength, optical clarity, durability over time, and low deformation or damage to microfeature geometry. We describe the procedure for bonding devices made from two popular thermoplastics, poly(methyl-methacrylate) (PMMA), and cyclo-olefin polymer (COP), as well as a variety of methods to characterize the quality of the resulting bonds, and strategies to troubleshoot low quality bonds. These methods can be used to develop new solvent bonding protocols for other plastic-solvent systems.

  9. 028. Migratory pneumonia—cryptogenic organizing pneumonia (COP)

    Science.gov (United States)

    Lagoudi, Kalliopi; Ioannidou, Despoina; Papadaki, Elena; Organtzis, Ioannis; Kostanta, Soultana; Papaioannou, Antonis; Moumtzi, Despoina; Porpodis, Konstantinos; Fouka, Evaggelia

    2015-01-01

    In this study were presented the clinical and laboratory findings of eight patients with migratory pneumonia, who were hospitalised in our clinic. It is about eight women with average age of 58±13 years with fever, weakness, dry cough, shortness of breath and who already had received antibiotics. Crackles were the most frequent evidence by the auscultation. All patients showed consolidation in chest radiography which resolved completely from the initial area and migrated in different areas. The chest HRCT showed opacity with air bronchogram and ground glass in places. Regarding to the respiratory function, patients showed mild restriction disorder (average values ± SD: FEV1% 83±24, FVC% 86±21, TLC% 82±16, DLco% 74±15). The average price of pO2 was 68+7 mmHg. The findings of BAL were: macrophages 51%±20%, lymphocytes 33.5%±14%, neutrophils 7.5%±3%, eosinophils 7%±8%. From diagnosis, we excluded eosinophilic pneumonia, infectious causes, collagen diseases and vasculitis. The findings of physical examination, chest radiography and the results of the BAL of all of the patients argued for Bronchiolitis obliterans organizing pneumonia (BOOP), the cause of which was not found (cryptogenic organizing pneumonia-COP). All patients responded directly to corticosteroids.

  10. Nitrate Reductases Are Relocalized to the Nucleus by AtSIZ1 and Their Levels Are Negatively Regulated by COP1 and Ammonium

    Directory of Open Access Journals (Sweden)

    Joo Yong Kim

    2018-04-01

    Full Text Available Nitrate reductases (NRs catalyze the first step in the reduction of nitrate to ammonium. NR activity is regulated by sumoylation through the E3 ligase activity of AtSIZ1. However, it is not clear how NRs interact with AtSIZ1 in the cell, or how nitrogen sources affect NR levels and their cellular localization. Here, we show that the subcellular localization of NRs is modulated by the E3 SUMO (Small ubiquitin-related modifier ligase AtSIZ1 and that NR protein levels are regulated by nitrogen sources. Transient expression analysis of GFP fusion proteins in onion epidermal cells showed that the NRs NIA1 and NIA2 localize to the cytoplasmic membrane, and that AtSIZ1 localizes to the nucleoplasm, including nuclear bodies, when expressed separately, whereas NRs and AtSIZ1 localize to the nucleus when co-expressed. Nitrate did not affect the subcellular localization of the NRs, but it caused AtSIZ1 to move from the nucleus to the cytoplasm. NRs were not detected in ammonium-treated cells, whereas the localization of AtSIZ1 was not altered by ammonium treatment. NR protein levels increased in response to nitrate but decreased in response to ammonium. In addition, NR protein levels increased in response to a 26S proteasome inhibitor and in cop1-4 and DN-COP1-overexpressing transgenic plants. NR protein degradation occurred later in cop1-4 than in the wild-type, although the NR proteins did not interact with COP1. Therefore, AtSIZ1 controls nuclear localization of NR proteins, and ammonium negatively regulates their levels. The function and stability of NR proteins might be post-translationally modulated by ubiquitination.

  11. What prospects for soil carbon sequestration in the CDM? COP-6 and beyond

    International Nuclear Information System (INIS)

    Ringius, L.

    2001-01-01

    Although generally supported by international experts and the United Nations Intergovernmental Panel on Climate Change (IPCC), carbon (C) sequestration has long been a contentious and difficult issue in global climate negotiations. As the recent sixth Conference of the Parties (COP-6) held in The Hague in November 2000 demonstrated, the 'sinks' issue divides both the industrialized countries and the developing countries. To understand the background of the C sink controversy, and in order to assess the political acceptability of direct foreign investments in soil C sequestration in developing countries as an eligible climate policy measure, this paper briefly summarizes the main issues in the international policy debate on sinks. The paper finally analyzes the informal outcomes of COP-6 and attempts to predict the outcomes of the resumed COP-6 (COP-6 bis) to be held in July 2001. (author)

  12. Three-Dimensional Sensor Common Operating Picture (3-D Sensor COP)

    Science.gov (United States)

    2017-01-01

    DEMs that have been computed from the point clouds . Additionally, Fusion3D can also display 3-D data created using photogrammetry software...Picture (3-D Sensor COP). To test the 3-D Sensor COP, we took advantage of a sensor network that had been deployed for the Enterprise Challenge 2016 at...took advantage of a sensor network that had been deployed for the Enterprise Challenge 2016 (EC16) at Fort Huachuca in Sierra Vista, Arizona. The

  13. Increase of COP for heat transformer in water purification systems. Part I - Increasing heat source temperature

    International Nuclear Information System (INIS)

    Siqueiros, J.; Romero, R.J.

    2007-01-01

    The integration of a water purification system in a heat transformer allows a fraction of heat obtained by the heat transformer to be recycled, increasing the heat source temperature. Consequently, the evaporator and generator temperatures are also increased. For any operating conditions, keeping the condenser and absorber temperatures and also the heat load to the evaporator and generator, a higher value of COP is obtained when only the evaporator and generator temperatures are increased. Simulation with proven software compares the performance of the modeling of an absorption heat transformer for water purification (AHTWP) operating with water/lithium bromide, as the working fluid-absorbent pair. Plots of enthalpy-based coefficients of performance (COP ET ) and the increase in the coefficient of performance (COP) are shown against absorber temperature for several thermodynamic operating conditions. The results showed that proposed (AHTWP) system is capable of increasing the original value of COP ET more than 120%, by recycling part of the energy from a water purification system. The proposed system allows to increase COP values from any experimental data for water purification or any other distillation system integrated to a heat transformer, regardless of the actual COP value and any working fluid-absorbent pair

  14. FACEBOOK for CoP of Researchers: Identifying the Needs and Evaluating the Compatibility

    Directory of Open Access Journals (Sweden)

    Sami Miniaoui

    2011-11-01

    Full Text Available Communities of practice (CoPs are increasingly capturing the interest of many fields such as business companies, education and organizations. Many CoPs were developed for people who have common interest in healthcare, agriculture and environment, and teaching. However, there is lack of COPs dedicated for researchers. This research aims to explore the appropriateness of Facebook (FB as a platform for serving a CoP of researchers. To achieve this goal, first we identify the needs of CoPs for researchers within UAE context. Consequently, we adopted qualitative research approach to elicit the needs. We applied the grounded theory method to analyze the data. The results of the analysis showed seven main needs: collaboration, debating, awareness/ notification, reference management, cross search, customization, tracking, and user orientation. Secondly, we evaluated the compatibility of FB features to the identified needs. Although we found that FB covers most of CoPs needs, there are few needs which are not met successfully so this raised some technical and practical issues, which have been highlighted in the paper.

  15. Risk Management Capability Maturity and Performance of Complex Product and System (CoPS Projects with an Asian Perspective

    Directory of Open Access Journals (Sweden)

    Ren, Y.

    2014-07-01

    Full Text Available Complex Products and Systems (CoPS are high value, technology and engineering-intensive capital goods. The motivation of this study is the persistent high failure rate of CoPS projects, Asian CoPS provider’s weak capability and lack of specific research on CoPS risk management. This paper evaluates risk management maturity level of CoPS projects against a general CoPS risk management capability maturity model (RM-CMM developed by the authors. An Asian based survey was conducted to investigate the value of RM to project performance, and Asian (non-Japanese CoPS implementers’ perceived application of RM practices, their strengths and weaknesses. The survey result shows that higher RM maturity level leads to higher CoPS project performance. It also shows project complexity and uncertainty moderates the relationship between some RM practices and project performance, which implies that a contingency approach should be adopted to manage CoPS risks effectively. In addition, it shows that Asian CoPS implementers are weak in RM process and there are also rooms for improvement in the softer aspects of organizational capabilities and robustness.

  16. The Copper Homeostasis Transcription Factor CopR Is Involved in H2O2 Stress in Lactobacillus plantarum CAUH2

    Directory of Open Access Journals (Sweden)

    Yang Yang

    2017-10-01

    Full Text Available Transcriptional factors (TFs play important roles in the responses to oxidative, acid, and other environmental stresses in Gram-positive bacteria, but the regulatory mechanism of TFs involved in oxidative stress remains unknown in lactic acid bacteria. In the present work, homologous overexpression strains with 43 TFs were constructed in the Lactobacillus plantarum CAUH2 parent strain. The strain overexpressing CopR displayed the highest sensitivity and a 110-fold decrease in survival rate under H2O2 challenge. The importance of CopR in the response to H2O2 stress was further confirmed by a 10.8-fold increase in the survival of a copR insertion mutant. In silico analysis of the genes flanking copR revealed putative CopR-binding “cop box” sequences in the promoter region of the adjacent gene copB encoding a Cu2+-exporting ATPase. Electrophoretic mobility shift assay (EMSA analysis demonstrated the specific binding of CopR with copB in vitro, suggesting copB is a target gene of CopR in L. plantarum. The role of CopB involved in oxidative stress was verified by the significantly decreased survival in the copB mutant. Furthermore, a growth defect in copper-containing medium demonstrated that CopB functions as an export ATPase for copper ions. Furthermore, EMSAs revealed that CopR functions as a regulator that negatively regulates copB gene and Cu2+ serves as inducer of CopR to activate the expression of CopB in response to H2O2 stress in L. plantarum CAUH2. Our findings indicated that CopR plays an important role in enhancing oxidative resistance by regulating copB to modulate copper homeostasis.

  17. The Relationship between the (In-)Stability of NORs and Their Chromosomal Location: The Example of Cercopithecidae and a Short Review of Other Primates.

    Science.gov (United States)

    Gerbault-Seureau, Michèle; Cacheux, Lauriane; Dutrillaux, Bernard

    2017-01-01

    Amongst Cercopithecidae, the species of the Cercopithecini tribe underwent a very active chromosome evolution, principally by fissions, which increased their chromosome number up to 72. In contrast, all the species of Papionini have fairly similar karyotypes with 42 chromosomes. In animals, nucleolus organizer regions (NORs) are generally considered as instable structures, which frequently vary in size, number, and location at both infra- and interspecific levels. Although in Cercopithecinae the NORs, involved in breaks, exchanges, and translocations, behave like fragile sites in somatic cells, their number and location appear to be very stable between species. Fluorescence in situ hybridization of a 28S rDNA probe on metaphase chromosomes displayed a unique interstitial location in either an acrocentric pair (in 12 species of Cercopithecini) or a metacentric pair (in 6 species of Papionini). A non-exhaustive survey of literature data on NOR location in other primates shows that numerical variations of the NORs principally depend on their location: most multiple NORs are in terminal positions, while almost all unique NORs are in interstitial positions. We propose that this correlation is the consequence of the selection against gametic imbalances involving the chromosomal material distal to the NORs, which is effective when they are interstitially, but not terminally, located. Thus, the consequences of the interstitial NOR instability for reproduction are essentially limited to their size variations, as observed in Cercopithecidae. © 2018 S. Karger AG, Basel.

  18. Nanostructured CoP: An efficient catalyst for degradation of organic pollutants by activating peroxymonosulfate

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Rui; Liu, Chao; Li, Jiansheng, E-mail: lijsh@mail.njust.edu.cn; Wang, Jing; Hu, Xingru; Sun, Xiuyun; Shen, Jinyou; Han, Weiqing; Wang, Lianjun

    2017-05-05

    Highlights: • The CoP/PMS system was first presented for decomposition of pollutants. • CoP exhibited dramatic catalytic activity. • Broadened pH range and favorable anti-interference of anions were achieved. • A possible mechanism for activation of PMS by CoP was proposed. - Abstract: A new catalyst system of CoP/peroxymonosulfate (PMS) is presented, which achieved significant improvement in catalytic activity. Nanostructured CoP, obtained by a simple solid-state reaction, exhibited dramatic catalytic activity with 97.2% degradation of orange II of 100 ppm within 4 min. Moreover, the high efficiency could be reached for other phenolic pollutants, i.e., phenol and 4-chlorophenol. The reaction rate is much higher than the most reported catalysts. Effect of parameters on catalytic activity of the catalyst was studied in detail. Notably, initial pH of the solution had a slight negative effect on the catalytic performance over the pH range 4.07–10.92, suggesting that CoP has the great adaptability of pH. CoP/PMS demonstrated excellent anti-interference performance toward anions (Cl{sup −}, NO{sub 3}{sup −}, and HCO{sub 3}{sup −}). In addition, the pathway of degradation of orange II is proposed by analyzing its intermediates. Based on the XPS spectra of CoP, the identification of the reactive species (·OH and SO{sub 4}·{sup −}) by electron paramagnetic resonance (EPR) analysis and quenching tests, a possible mechanism for activation of PMS by CoP was proposed. Considering the dramatic catalytic activity, a wide range of pH catalyst suited, CoP is believed to provide robust support for the promising industrial application of AOPs.

  19. COP1 Controls Abiotic Stress Responses by Modulating AtSIZ1 Function Through its E3 Ubiquitin Ligase Activity

    Directory of Open Access Journals (Sweden)

    Joo Yong Kim

    2016-08-01

    Full Text Available Ubiquitination and sumoylation are essential post-translational modifications that regulate growth and development processes in plants, including control of hormone signaling mechanisms and responses to stress. This study showed that COP1 (Constitutive photomorphogenic 1 regulated the activity of Arabidopsis E3 SUMO (Small ubiquitin-related modifier ligase AtSIZ1 through its E3 ubiquitin ligase activity. Yeast two hybrid analysis demonstrated that COP1 and AtSIZ1 directly interacted with one another, and subcellular localization assays indicated that COP1 and AtSIZ1 co-localized in nuclear bodies. Analysis of ubiquitination showed that AtSIZ1 was polyubiquitinated by COP1. The AtSIZ1 level was higher in cop1-4 mutants than in wild-type seedlings under light or dark conditions, and overexpression of a dominant-negative (DN-COP1 mutant led to a substantial increase in AtSIZ1 accumulation. In addition, under drought, cold, and high salt conditions, SUMO-conjugate levels were elevated in DN-COP1-overexpressing plants and cop1-4 mutant plants compared to wild-type plants. Taken together, our results indicate that COP1 controls responses to abiotic stress by modulation of AtSIZ1 levels and activity.

  20. Fingerprinting and diversity of bacterial copA genes in response to soil types, soil organic status and copper contamination.

    Science.gov (United States)

    Lejon, David P H; Nowak, Virginie; Bouko, Sabrina; Pascault, Noémie; Mougel, Christophe; Martins, Jean M F; Ranjard, Lionel

    2007-09-01

    A molecular fingerprinting assay was developed to assess the diversity of copA genes, one of the genetic determinants involved in bacterial resistance to copper. Consensus primers of the copA genes were deduced from an alignment of sequences from proteobacterial strains. A PCR detection procedure was optimized for bacterial strains and allowed the description of a novel copA genetic determinant in Pseudomonas fluorescens. The copA DNA fingerprinting procedure was optimized for DNA directly extracted from soils differing in their physico-chemical characteristics and in their organic status (SOS). Particular copA genetic structures were obtained for each studied soil and a coinertia analysis with soil physico-chemical characteristics revealed the strong influence of pH, soil texture and the quality of soil organic matter. The molecular phylogeny of copA gene confirmed that specific copA genes clusters are specific for each SOS. Furthermore, this study demonstrates that this approach was sensitive to short-term responses of copA gene diversity to copper additions to soil samples, suggesting that community adaptation is preferentially controlled by the diversity of the innate copA genes rather than by the bioavailability of the metal.

  1. Locative media

    CERN Document Server

    Wilken, Rowan

    2014-01-01

    Not only is locative media one of the fastest growing areas in digital technology, but questions of location and location-awareness are increasingly central to our contemporary engagements with online and mobile media, and indeed media and culture generally. This volume is a comprehensive account of the various location-based technologies, services, applications, and cultures, as media, with an aim to identify, inventory, explore, and critique their cultural, economic, political, social, and policy dimensions internationally. In particular, the collection is organized around the perception that the growth of locative media gives rise to a number of crucial questions concerning the areas of culture, economy, and policy.

  2. Stability of referential signalling across time and locations: testing alarm calls of Australian magpies (Gymnorhina tibicen in urban and rural Australia and in Fiji

    Directory of Open Access Journals (Sweden)

    Gisela Kaplan

    2013-07-01

    Full Text Available In many avian species, vocal repertoire expands and changes throughout life as new syllables are added and sounds adapted to neighbours and circumstances. Referential signals, on the other hand, demand stability and lack of variation so that their meaning can be understood by conspecifics at all times. It is not known how stable such signals may be when the context is changed entirely but the point of reference remains unchanged. We investigated these questions in a rare case of forced translocation of an avian species, the Australian magpie (Gymnorhina tibicen, from Australia to the remote Fijian island of Taveuni decades ago. By using playbacks of vocalisations to 45 magpie groups in Australia, we first established that magpies use functionally referential signals in their alarm call repertoire signalling aerial danger (measured as looking up in response to a specific alarm call even though the speakers were on the ground. With these results in hand, we then used the same playbacks to magpie groups on the island of Taveuni. Our results showed that the meaning of one specific call (eagle alarm call is stable and maintained even in populations that have been isolated from Australian conspecifics over many (at least 10 generations. To our knowledge, this is the first time such a stability of a referential signal has been shown in the natural habitat.

  3. Lightweight and Statistical Techniques for Petascale Debugging: Correctness on Petascale Systems (CoPS) Preliminry Report

    Energy Technology Data Exchange (ETDEWEB)

    de Supinski, B R; Miller, B P; Liblit, B

    2011-09-13

    Petascale platforms with O(10{sup 5}) and O(10{sup 6}) processing cores are driving advancements in a wide range of scientific disciplines. These large systems create unprecedented application development challenges. Scalable correctness tools are critical to shorten the time-to-solution on these systems. Currently, many DOE application developers use primitive manual debugging based on printf or traditional debuggers such as TotalView or DDT. This paradigm breaks down beyond a few thousand cores, yet bugs often arise above that scale. Programmers must reproduce problems in smaller runs to analyze them with traditional tools, or else perform repeated runs at scale using only primitive techniques. Even when traditional tools run at scale, the approach wastes substantial effort and computation cycles. Continued scientific progress demands new paradigms for debugging large-scale applications. The Correctness on Petascale Systems (CoPS) project is developing a revolutionary debugging scheme that will reduce the debugging problem to a scale that human developers can comprehend. The scheme can provide precise diagnoses of the root causes of failure, including suggestions of the location and the type of errors down to the level of code regions or even a single execution point. Our fundamentally new strategy combines and expands three relatively new complementary debugging approaches. The Stack Trace Analysis Tool (STAT), a 2011 R&D 100 Award Winner, identifies behavior equivalence classes in MPI jobs and highlights behavior when elements of the class demonstrate divergent behavior, often the first indicator of an error. The Cooperative Bug Isolation (CBI) project has developed statistical techniques for isolating programming errors in widely deployed code that we will adapt to large-scale parallel applications. Finally, we are developing a new approach to parallelizing expensive correctness analyses, such as analysis of memory usage in the Memgrind tool. In the first two

  4. Prediction of Ryznar Stability Index for Treated Water of WTPs Located on Al-Karakh Side of Baghdad City using Artificial Neural Network (ANN Technique

    Directory of Open Access Journals (Sweden)

    Awatif Soaded Alsaqqar

    2016-06-01

    Full Text Available In this research an Artificial Neural Network (ANN technique was applied for the prediction of Ryznar Index (RI of the flowing water from WTPs in Al-Karakh side (left side in Baghdad city for year 2013. Three models (ANN1, ANN2 and ANN3 have been developed and tested using data from Baghdad Mayoralty (Amanat Baghdad including drinking water quality for the period 2004 to 2013. The results indicate that it is quite possible to use an artificial neural networks in predicting the stability index (RI with a good degree of accuracy. Where ANN 2 model could be used to predict RI for the effluents from Al-Karakh, Al-Qadisiya and Al-Karama WTPs as the highest correlation coefficient were obtained 92.4, 82.9 and 79.1% respectively. For Al-Dora WTP, ANN 3 model could be used as R was 92.8%.

  5. Location, location, location: Extracting location value from house prices

    OpenAIRE

    Kolbe, Jens; Schulz, Rainer; Wersing, Martin; Werwatz, Axel

    2012-01-01

    The price for a single-family house depends both on the characteristics of the building and on its location. We propose a novel semiparametric method to extract location values from house prices. After splitting house prices into building and land components, location values are estimated with adaptive weight smoothing. The adaptive estimator requires neither strong smoothness assumptions nor local symmetry. We apply the method to house transactions from Berlin, Germany. The estimated surface...

  6. Low-grade heat and its definitions of Coefficient-of-Performance (COP)

    International Nuclear Information System (INIS)

    Wang, Lin-Shu; Ma, Peizheng

    2015-01-01

    Use of fire for low grade heat, still widely practiced today, is wasteful because it is based on the principle of heat production – which should have become an outmoded idea post-Carnot for low grade heat application as an exergy analysis will readily conclude. Instead of application of exergy analysis, a new thermodynamic analysis resulting from the unification of Kelvin's energy principle and the entropy principle, formulated recently (called the entropic theory of heat), is applied here to reexamine the problem of building heating. Other than improving envelope heat resistance, conventional building efficiency gain is predominantly obtained by improving HVAC efficiency (i.e., boiler efficiency); our finding shows that there is in fact large room in improving the building heating operation surpassing 100% boiler efficiency, as demonstrated by the large value of the Kelvin limit (the theoretical upper bound of Thermal COP). This theoretical possibility of generous amount of heat from fire suggests additional possibilities of heat from primary energy other than fire, and the disclosure of these possibilities by applying the triad framework in the entropic theory of heat in terms of alternative definitions of Coefficient of Performance (COP). Consideration of such alternative COPs suggests real possibility of efficiently and cost effectively obtaining low grade heat from primary energy. - Highlights: • Importance of thinking heat extraction for high energy efficiency in buildings. • The concept of Thermal COP and the determination of its (maximum) Kelvin limit. • Key to find the sweet spot of using heat pump is thinking general heat extraction. • triadCOP &eThermalCOP are measure of energy transformation in the triad framework

  7. Association with β-COP Regulates the Trafficking of the Newly Synthesized Na,K-ATPase*

    Science.gov (United States)

    Morton, Michael J.; Farr, Glen A.; Hull, Michael; Capendeguy, Oihana; Horisberger, Jean-Daniel; Caplan, Michael J.

    2010-01-01

    Plasma membrane expression of the Na,K-ATPase requires assembly of its α- and β-subunits. Using a novel labeling technique to identify Na,K-ATPase partner proteins, we detected an interaction between the Na,K-ATPase α-subunit and the coat protein, β-COP, a component of the COP-I complex. When expressed in the absence of the Na,K-ATPase β-subunit, the Na,K-ATPase α-subunit interacts with β-COP, is retained in the endoplasmic reticulum, and is targeted for degradation. In the presence of the Na,K-ATPase β-subunit, the α-subunit does not interact with β-COP and traffics to the plasma membrane. Pulse-chase experiments demonstrate that in cells expressing both the Na,K-ATPase α- and β-subunits, newly synthesized α-subunit associates with β-COP immediately after its synthesis but that this interaction does not constitute an obligate intermediate in the assembly of the α- and β-subunits to form the pump holoenzyme. The interaction with β-COP was reduced by mutating a dibasic motif at Lys54 in the Na,K-ATPase α-subunit. This mutant α-subunit is not retained in the endoplasmic reticulum and reaches the plasma membrane, even in the absence of Na,K-ATPase β-subunit expression. Although the Lys54 α-subunit reaches the cell surface without need for β-subunit assembly, it is only functional as an ion-transporting ATPase in the presence of the β-subunit. PMID:20801885

  8. Postural stability in young and old women

    DEFF Research Database (Denmark)

    Jørgensen, Martin Grønbech

    at an early stage, good knowledge and sensitive measurements of postural stability are essential. In addition, in order to develop effective intervention strategies such knowledge is of major importance. However, no single postural stability parameter has effectively been able to identify individuals at risk...... of falling. Hence, there is a strong need for development and identification of sensitive postural sway parameters in various demographic groups. The aim of this study was to explore differences in postural stability between physically active old (O) and young (Y) women using newly developed sway parameters....... METHODS AND MATERIALS: Center of pressure (CoP) excursion was measured (100 Hz) by force plate (AMTI) analysis in old (72.5±6.3 years) and young (25.8±1.6 years) women during static 2-leg (bilateral) and 1-leg (unilateral) standing (15-s) with eyes opened. RESULTS: O demonstrated elevated CoP sway length...

  9. World Climate Conference - a play re-enacting the COPs

    Science.gov (United States)

    Vamborg, Freja S. E.; Klockmann, Marlene; Koch, Boris P.; Otto, Juliane; Rauser, Florian; Schemann, Vera; Sonntag, Sebastian; Haug, Helgard; Kaegi, Stefan; Wetzel, Daniel; Schipper, Imanuel; Bochow, Jörg

    2016-04-01

    Last December, Paris was the host city for the 21st Conference of the Parties (COP21) of the United Nations Framework Convention on Climate Change (UNFCCC). Representatives of 195 countries met to dispute a legally binding climate agreement - a highly complex process involving thousands of politicians, scientists and activists, that to date has taken over two decades. The director ensemble "Rimini Protokoll" re-enacted this mammoth-scale drama of diplomacy in the play "Weltklimakonferenz" (World Climate Conference) at the "Deutsches Schauspielhaus" theatre in Hamburg, Germany. Since the opening night (21st Nov. 2014), the play has been performed 16 times, reaching an audience of over 9000. All performers in the play were experts and scientists at different stages of their careers, including PhD students, journalists and professors. Each spectator took on the identity of a delegate of one of the 195 participating countries. We will present the project and the performance, thereby highlighting the role of and the interaction between the spectators and early career scientists. In a nutshell the play went as follows (https://vimeo.com/137817619); after an opening ceremony, the audience was divided up into seven groups, each of which was given advice by experts in several different briefings. These informed on country-specific challenges caused by the social and economic situation, possible future climatic changes and negotiating tactics. In addition, the delegations had bilateral meetings, enabling them to exchange views and experiences with one another. Towards the end of the play each delegation was asked to submit a national commitment to greenhouse gas reduction and a financial contribution to the Green Climate Fund. Based on these national commitments, the final plenum revealed whether or not the delegations had managed to submit reductions compatible with restricting global warming to 2°C compared to pre-industrial times. Due to their direct personal involvement

  10. The Young Generation at UNICEF COP6 ... and other flexibility mechanisms

    International Nuclear Information System (INIS)

    Meskens, Gaston; Avezou, Florence

    2001-01-01

    Climate change and long term energy strategies are world-scale common concerns, and decisions taken now will have an important impact on the quality of life of our future generations. As electricity production is one of the major CO 2 sources (next to transport and domestic use of energy), nuclear can play a role when it comes to agree on policies and measures to cut global warming - even with regard to sensitive topics such as joint implementation, clean development mechanisms and trading. The Sixth Conference of the Parties (COP6) on the UN Framework Convention on Climate Change met in The Hague (Netherlands) on November 13-24, 2000. It was expected that the final details on the implementation of the Kyoto Protocol would be determined during this conference, so that developed countries can start the process of ratification of the accords. It turned out different. For the nuclear industry, there is optimism. The conference was a success because no agreement is better than exclusion. The industry received a lot of attention, that was more negative than positive, but still, it is open for discussion. COP6 was very different from the previous COP's and SB's. There has never been a bigger difference in perception of nuclear between 'buzz in the corridors' (based on actual positive evolutions in some countries) on the one hand, and references in the official talks on the other hand. This also means that the negotiations are becoming more and more complicated and that a lot of diplomacy is necessary. Given the sensitiveness of the topic, the nuclear representatives decided to keep 'low profile' at COP6. For what the impact of the Young Generation (YG) contacts with the pressure group are concerned, we foresaw COP6 to be the turning point, and we were right. The surprise effect (COP3) is gone, the period of curiosity and 'sympathy' (COP4) and neglect (COP5) is passed and, now that the green groups see that our attendance has an effect, they start to take us seriously

  11. Police officers who commit suicide by cop: a clinical study with analysis.

    Science.gov (United States)

    Arias, Elizabeth A; Schlesinger, Louis B; Pinizzotto, Anthony J; Davis, Edward F; Fava, Joanna L; Dewey, Lauren M

    2008-11-01

    Suicide by cop has become a familiar topic among members of law enforcement, mental health professionals, and the general public. This paper presents two cases where police officers chose to commit suicide by getting other police officers to kill them. The two police officers studied, by examination of closed case files, were found to be similar to civilians who committed suicide by cop on several demographic (gender, age, history of mental illness, and suicide attempts), and situational (stress factors, trigger) variables. The cases help us to understand possible motives and management for individuals who choose to end their life in this manner.

  12. Les transitions énergétiques après les COP 21 et 22

    OpenAIRE

    Balibar , Sebastien

    2017-01-01

    International audience; How far are we in the urgent fight against the climate change? This article starts with a short analysis of the results of COP21 and COP22, the two “conferences of parties” where goals have been defined. Now, to define goals is one thing, but to reach these goals is another thing. In its second part, this article analyzes the energy transition that has been voted by France in 2015, and compares it to what is planned in other countries, especially in Germany.; Où en som...

  13. The pH Stability of Foot-and-Mouth Disease Virus Particles Is Modulated by Residues Located at the Pentameric Interface and in the N Terminus of VP1.

    Science.gov (United States)

    Caridi, Flavia; Vázquez-Calvo, Angela; Sobrino, Francisco; Martín-Acebes, Miguel A

    2015-05-01

    The picornavirus foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects important livestock species. The FMDV capsid is highly acid labile, and viral particles lose infectivity due to their disassembly at pH values slightly below neutrality. This acid sensitivity is related to the mechanism of viral uncoating and genome penetration from endosomes. In this study, we have analyzed the molecular basis of FMDV acid-induced disassembly by isolating and characterizing a panel of novel FMDV mutants differing in acid sensitivity. Amino acid replacements altering virion stability were preferentially distributed in two different regions of the capsid: the N terminus of VP1 and the pentameric interface. Even more, the acid labile phenotype induced by a mutation located at the pentameric interface in VP3 could be compensated by introduction of an amino acid substitution in the N terminus of VP1. These results indicate that the acid sensitivity of FMDV can be considered a multifactorial trait and that virion stability is the fine-tuned product of the interaction between residues from different capsid proteins, in particular those located within the N terminus of VP1 or close to the pentameric interface. The viral capsid protects the viral genome from environmental factors and contributes to virus dissemination and infection. Thus, understanding of the molecular mechanisms that modulate capsid stability is of interest for the basic knowledge of the biology of viruses and as a tool to improve the stability of conventional vaccines based on inactivated virions or empty capsids. Using foot-and-mouth disease virus (FMDV), which displays a capsid with extreme acid sensitivity, we have performed a genetic study to identify the molecular determinants involved in capsid stability. A panel of FMDV mutants with differential sensitivity to acidic pH was generated and characterized, and the results showed that two different regions of FMDV

  14. Increase of COP for heat transformer in water purification systems. Part II - Without increasing heat source temperature

    International Nuclear Information System (INIS)

    Romero, R.J.; Siqueiros, J.; Huicochea, A.

    2007-01-01

    The integration of a water purification system allows a heat transformer to increase the actual coefficient of performance, by the reduction of the amount of heat supplied by unit of heat. A new defined COP called COP WP is proposed for the present system, which considers the fraction of heat recycled. Simulation with proven software compares the performance of the modeling of an absorption heat transformer for water purification (AHTWP) operating with water/lithium bromide, as working fluid-absorbent pair. Plots of enthalpy-based coefficients of performance (COP ET ) and water purification coefficient of performance (COP WP ) are shown against absorber temperature for several thermodynamic operating conditions. The results showed that the proposed (AHTWP) system is capable of increasing the original value of COP ET up to 1.6 times its original value by recycling energy from a water purification system. The proposed COP WP allows increments for COP values from any experimental data for water purification or for any other distillation system integrated to a heat transformer, regardless of actual COP A value or working fluid-absorbent pair

  15. 30 CFR 285.659 - What requirements must I include in my SAP, COP, or GAP regarding air quality?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What requirements must I include in my SAP, COP, or GAP regarding air quality? 285.659 Section 285.659 Mineral Resources MINERALS MANAGEMENT SERVICE... must I include in my SAP, COP, or GAP regarding air quality? (a) You must comply with the Clean Air Act...

  16. Library Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours. The map below does not display...

  17. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1

    Directory of Open Access Journals (Sweden)

    Wang Haiyang

    2002-12-01

    Full Text Available Abstract Background Constitutive photomorphogenic 1 (COP1 has been defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation. Although COP1 mammalian homologue has been previously reported, its function and distribution in animal kingdom are not known. Results Here we report the characterization of full-length human and mouse COP1 cDNAs and the genomic structures of the COP1 genes from several different species. Mammalian COP1 protein binds to ubiquitinated proteins in vivo and is itself ubiquitinated. Furthermore, mammalian COP1 is predominately nuclear localized and exists primarily as a complex of over 700 kDa. Through mutagenesis studies, we have defined a leucine-rich nuclear export signal (NES within the coiled-coil domain of mammalian COP1 and a nuclear localization signal (NLS, which is composed of two clusters of positive-charged amino acids, bridged by the RING finger. Disruption of the RING finger structure abolishes the nuclear import, while deletion of the entire RING finger restores the nuclear import. Conclusions Our data suggest that mammalian COP1, similar to its plant homologue, may play a role in ubiquitination. Mammalian COP1 contains a classic leucine-rich NES and a novel bipartite NLS bridged by a RING finger domain. We propose a working model in which the COP1 RING finger functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite NLS. Therefore, in addition to its well-characterized role in ubiquitination, the RING finger domain may also play a structural role in nuclear import.

  18. CoP nanosheet assembly grown on carbon cloth: A highly efficient electrocatalyst for hydrogen generation

    KAUST Repository

    Yang, Xiulin

    2015-07-01

    There exists a strong demand to replace expensive noble metal catalysts with cheap metal sulfides or phosphides for hydrogen evolution reaction (HER). Recently metal phosphides such as NixP, FeP and CoP have been considered as promising candidates to replace Pt cathodes. Here we report that the nanocrystalline CoP nanosheet assembly on carbon cloth can be formed by a two-step process: electrochemical deposition of Co species followed by gas phase phosphidation. The CoP catalyst in this report exhibits a Tafel slope of 30.1mV/dec in 0.5M H2SO4 and 42.6mV/dec in 1M KOH. The high HER performance of our CoP catalysts is attributed to the rugae-like morphology which results in a high double-layer capacitance and high density of active sites, estimated as 7.77×1017sites/cm2. © 2015 Elsevier Ltd.

  19. HUBUNGAN TEGANGAN INPUT KOMPRESOR DAN TEKANAN REFRIGERAN TERHADAP COP MESIN PENDINGIN RUANGAN

    Directory of Open Access Journals (Sweden)

    Eko Budiyanto

    2014-06-01

    Full Text Available Listrik merupakan sumber energi utama pada peralatan elektronik terutama pada AC ( air conditioner,  sehingga besar kecilnya tegangan listrik sangat mempengaruhi kinerja mesin. Selain tegangan listrik, kerja mesin pendingin juga dipengaruhi oleh tekanan refrigeran. Penelitian ini bertujuan untuk mengetahui hubungan tegangan input kompresor dan tekanan refrigeran terhadap COP serta untuk mengetahui perubahan temperatur yang terjadi pada evaporator dan kondensor karena pengaruh tegangan input kompresor dan tekanan refrigeran. Penelitian dilakukan dengan cara melakukan pengambilan data pada AC split dengan tegangan input kompresor yang divariasikan 200V, 210V, 220V, dan 230V (tekanan refrigeran 70 Psi. Selain memvariasikan tegangan input kompresor juga memvariasikan pada tekanan refrigeran yaitu pada tekanan refrigeran 30 Psi, 50 Psi, dan 70 Psi (tegangan input kompresor 220V. Dari hasil perhitungan data diperoleh nilai COP pada tegangan input kompresor 200V, 210V, 220V, dan 230V masing-masing adalah 16,87; 17,855; 19,865; dan 18,23. COP pada tekanan refrigeran 30 Psi, 50 Psi, dan 70 Psi masing-masing adalah 14,980; 17,296; 19,865. Dari besarnya nilai COP pada beberapa varian percobaan didapatkan hasil bahwa tegangan input kompresor yang paling baik adalah 220V dan tekanan refrigeran yang paling baik adalah 70Psi.

  20. International climate change policy: background and significance of upcoming COP17 meeting for South Africa

    CSIR Research Space (South Africa)

    Thambiran, Tirusha

    2011-09-01

    Full Text Available COP17 is primarily a meeting about climate change and what can be done internationally to mitigate climate change. The overarching mitigation goal is to develop a legally binding agreement to control and limit the amount of GHGs that countries would...

  1. Tackling the climate targets set by the Paris Agreement (COP 21 ...

    African Journals Online (AJOL)

    Tackling the climate targets set by the Paris Agreement (COP 21): Green leadership empowers public hospitals to overcome obstacles and challenges in a ... To improve commitment from all involved roleplayers, political leadership, supportive government policies and financial funding is mandatory, or public hospitals will ...

  2. Gene Locater

    DEFF Research Database (Denmark)

    Anwar, Muhammad Zohaib; Sehar, Anoosha; Rehman, Inayat-Ur

    2012-01-01

    software's for calculating recombination frequency is mostly limited to the range and flexibility of this type of analysis. GENE LOCATER is a fully customizable program for calculating recombination frequency, written in JAVA. Through an easy-to-use interface, GENE LOCATOR allows users a high degree...... of flexibility in calculating genetic linkage and displaying linkage group. Among other features, this software enables user to identify linkage groups with output visualized graphically. The program calculates interference and coefficient of coincidence with elevated accuracy in sample datasets. AVAILABILITY...

  3. Density-functional band-structure calculations for La-, Y-, and Sc-filled CoP3-based skutterudite structures

    International Nuclear Information System (INIS)

    Loevvik, O.M.; Prytz, O.

    2004-01-01

    The crystal structure, thermodynamic stability, and electronic structure of La-, Y-, and Sc-filled CoP 3 are predicted from density-functional band-structure calculations. The size of the cubic voids in the skutterudite structure is changed much less than the difference in size between the different filling atoms, and we expect that the larger rattling amplitude of the smaller Sc and Y atoms may decrease the lattice thermal conductivity of Sc- and Y-filled structures significantly compared to La-filled structures. The solubility of La, Y, and Sc in CoP 3 is calculated to be around 5, 3-6 %, and below 1% at 0 K, respectively. Based on similar systems, this is expected to increase considerably if Fe is substituted for Co. Fe substitution is also expected to compensate the increased charge carrier concentration of the filled structures that is seen in the calculated electron density of states. In conclusion, Sc- or Y-filled (FeCo)P 3 skutterudite structures are promising materials for thermoelectric applications

  4. The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans

    Science.gov (United States)

    Singh, Kamna; Senadheera, Dilani B.; Lévesque, Céline M.

    2015-01-01

    ABSTRACT In bacteria, copper homeostasis is closely monitored to ensure proper cellular functions while avoiding cell damage. Most Gram-positive bacteria utilize the copYABZ operon for copper homeostasis, where copA and copB encode copper-transporting P-type ATPases, whereas copY and copZ regulate the expression of the cop operon. Streptococcus mutans is a biofilm-forming oral pathogen that harbors a putative copper-transporting copYAZ operon. Here, we characterized the role of copYAZ operon in the physiology of S. mutans and delineated the mechanisms of copper-induced toxicity in this bacterium. We observed that copper induced toxicity in S. mutans cells by generating oxidative stress and disrupting their membrane potential. Deletion of the copYAZ operon in S. mutans strain UA159 resulted in reduced cell viability under copper, acid, and oxidative stress relative to the viability of the wild type under these conditions. Furthermore, the ability of S. mutans to form biofilms and develop genetic competence was impaired under copper stress. Briefly, copper stress significantly reduced cell adherence and total biofilm biomass, concomitantly repressing the transcription of the gtfB, gtfC, gtfD, gbpB, and gbpC genes, whose products have roles in maintaining the structural and/or functional integrity of the S. mutans biofilm. Furthermore, supplementation with copper or loss of copYAZ resulted in significant reductions in transformability and in the transcription of competence-associated genes. Copper transport assays revealed that the ΔcopYAZ strain accrued significantly large amounts of intracellular copper compared with the amount of copper accumulation in the wild-type strain, thereby demonstrating a role for CopYAZ in the copper efflux of S. mutans. The complementation of the CopYAZ system restored copper expulsion, membrane potential, and stress tolerance in the copYAZ-null mutant. Taking these results collectively, we have established the function of the S. mutans

  5. The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans.

    Science.gov (United States)

    Singh, Kamna; Senadheera, Dilani B; Lévesque, Céline M; Cvitkovitch, Dennis G

    2015-08-01

    In bacteria, copper homeostasis is closely monitored to ensure proper cellular functions while avoiding cell damage. Most Gram-positive bacteria utilize the copYABZ operon for copper homeostasis, where copA and copB encode copper-transporting P-type ATPases, whereas copY and copZ regulate the expression of the cop operon. Streptococcus mutans is a biofilm-forming oral pathogen that harbors a putative copper-transporting copYAZ operon. Here, we characterized the role of copYAZ operon in the physiology of S. mutans and delineated the mechanisms of copper-induced toxicity in this bacterium. We observed that copper induced toxicity in S. mutans cells by generating oxidative stress and disrupting their membrane potential. Deletion of the copYAZ operon in S. mutans strain UA159 resulted in reduced cell viability under copper, acid, and oxidative stress relative to the viability of the wild type under these conditions. Furthermore, the ability of S. mutans to form biofilms and develop genetic competence was impaired under copper stress. Briefly, copper stress significantly reduced cell adherence and total biofilm biomass, concomitantly repressing the transcription of the gtfB, gtfC, gtfD, gbpB, and gbpC genes, whose products have roles in maintaining the structural and/or functional integrity of the S. mutans biofilm. Furthermore, supplementation with copper or loss of copYAZ resulted in significant reductions in transformability and in the transcription of competence-associated genes. Copper transport assays revealed that the ΔcopYAZ strain accrued significantly large amounts of intracellular copper compared with the amount of copper accumulation in the wild-type strain, thereby demonstrating a role for CopYAZ in the copper efflux of S. mutans. The complementation of the CopYAZ system restored copper expulsion, membrane potential, and stress tolerance in the copYAZ-null mutant. Taking these results collectively, we have established the function of the S. mutans Cop

  6. The COP22 in Africa. Is the African group of negotiators in tune?

    International Nuclear Information System (INIS)

    Maupin, Agathe

    2016-01-01

    As the COP22 is about to take place in an African country (Morocco), the author discusses how African countries deal with the fact that they belong to different negotiation groups, and which are the strategies adopted until now by the group of African negotiators to cope with the delicate combination of national requests and continental vision. Thus, the author recalls and comments the positions adopted since COP1 by the five groups of negotiators and their relationships with different international bodies. She discuses the posture and strategies of African countries, and how to gather them about topics of common interest such as adaptation, financing and transfer of capacities and technologies. She also comments the emergence of a new strategy regarding financing mechanisms

  7. COP21: a 1.5 deg. C or 2 deg. C target?

    International Nuclear Information System (INIS)

    Huet, Sylvestre

    2015-01-01

    This article discusses and somehow criticises the definition of a limitation for temperature increase to 1.5 degree rather than 2 degree. Even though this objective is grounded on a positive motivation, notably to support countries which are the most threatened by sea level rise, the article shows that this 1.5 degree objective cannot be met, and is even about to be already reached due to the level of already emitted greenhouse gases, notably CO 2 . Then it discusses the interest of COP21 debate and agreement as it defines an unreachable objective. This leads to the observation of an insufficiency of policies expressed at the COP21, with however the merit to admit the truth: the impossibility to define a route which would allow the 2 degree limit not to be overcome, as it is shown by various data of evolution of emissions

  8. Insect peptide CopA3-induced protein degradation of p27Kip1 stimulates proliferation and protects neuronal cells from apoptosis

    International Nuclear Information System (INIS)

    Nam, Seung Taek; Kim, Dae Hong; Lee, Min Bum; Nam, Hyo Jung; Kang, Jin Ku; Park, Mi Jung; Lee, Ik Hwan; Seok, Heon; Lee, Dong Gun; Hwang, Jae Sam; Kim, Ho

    2013-01-01

    Highlights: •CopA3 peptide isolated from the Korean dung beetle has antimicrobial activity. •Our study reported that CopA3 has anticancer and immunosuppressive effects. •We here demonstrated that CopA3 has neurotropic and neuroprotective effects. •CopA3 degrades p27Kip1 protein and this mediates effects of CopA3 on neuronal cells. -- Abstract: We recently demonstrated that the antibacterial peptide, CopA3 (a D-type disulfide dimer peptide, LLCIALRKK), inhibits LPS-induced macrophage activation and also has anticancer activity in leukemia cells. Here, we examined whether CopA3 could affect neuronal cell proliferation. We found that CopA3 time-dependently increased cell proliferation by up to 31 ± 2% in human neuroblastoma SH-SY5Y cells, and up to 29 ± 2% in neural stem cells isolated from neonatal mouse brains. In both cell types, CopA3 also significantly inhibited the apoptosis and viability losses caused by 6-hydroxy dopamine (a Parkinson disease-mimicking agent) and okadaic acid (an Alzheimer’s disease-mimicking agent). Immunoblotting revealed that the p27Kip1 protein (a negative regulator of cell cycle progression) was markedly degraded in CopA3-treated SH-SY5Y cells. Conversely, an adenovirus expressing p27Kip1 significantly inhibited the antiapoptotic effects of CopA3 against 6-hydroxy dopamine- and okadaic acid-induced apoptosis, and decreased the neurotropic effects of CopA3. These results collectively suggest that CopA3-mediated protein degradation of p27Kip1 may be the main mechanism through which CopA3 exerts neuroprotective and neurotropic effects

  9. Insect peptide CopA3-induced protein degradation of p27Kip1 stimulates proliferation and protects neuronal cells from apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Seung Taek; Kim, Dae Hong; Lee, Min Bum; Nam, Hyo Jung; Kang, Jin Ku; Park, Mi Jung; Lee, Ik Hwan [Department of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido 487-711 (Korea, Republic of); Seok, Heon [Department of Biomedical Science, Jungwon University, Goesan, Chungcheongbukdo 367-700 (Korea, Republic of); Lee, Dong Gun [School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Hwang, Jae Sam [Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon 441-707 (Korea, Republic of); Kim, Ho, E-mail: hokim@daejin.ac.kr [Department of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido 487-711 (Korea, Republic of)

    2013-07-19

    Highlights: •CopA3 peptide isolated from the Korean dung beetle has antimicrobial activity. •Our study reported that CopA3 has anticancer and immunosuppressive effects. •We here demonstrated that CopA3 has neurotropic and neuroprotective effects. •CopA3 degrades p27Kip1 protein and this mediates effects of CopA3 on neuronal cells. -- Abstract: We recently demonstrated that the antibacterial peptide, CopA3 (a D-type disulfide dimer peptide, LLCIALRKK), inhibits LPS-induced macrophage activation and also has anticancer activity in leukemia cells. Here, we examined whether CopA3 could affect neuronal cell proliferation. We found that CopA3 time-dependently increased cell proliferation by up to 31 ± 2% in human neuroblastoma SH-SY5Y cells, and up to 29 ± 2% in neural stem cells isolated from neonatal mouse brains. In both cell types, CopA3 also significantly inhibited the apoptosis and viability losses caused by 6-hydroxy dopamine (a Parkinson disease-mimicking agent) and okadaic acid (an Alzheimer’s disease-mimicking agent). Immunoblotting revealed that the p27Kip1 protein (a negative regulator of cell cycle progression) was markedly degraded in CopA3-treated SH-SY5Y cells. Conversely, an adenovirus expressing p27Kip1 significantly inhibited the antiapoptotic effects of CopA3 against 6-hydroxy dopamine- and okadaic acid-induced apoptosis, and decreased the neurotropic effects of CopA3. These results collectively suggest that CopA3-mediated protein degradation of p27Kip1 may be the main mechanism through which CopA3 exerts neuroprotective and neurotropic effects.

  10. The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms.

    Science.gov (United States)

    Barth, Emanuel; Hübler, Ron; Baniahmad, Aria; Marz, Manja

    2016-05-02

    The COP9 signalosome (CSN) is a highly conserved protein complex, recently being crystallized for human. In mammals and plants the COP9 complex consists of nine subunits, CSN 1-8 and CSNAP. The CSN regulates the activity of culling ring E3 ubiquitin and plays central roles in pleiotropy, cell cycle, and defense of pathogens. Despite the interesting and essential functions, a thorough analysis of the CSN subunits in evolutionary comparative perspective is missing. Here we compared 61 eukaryotic genomes including plants, animals, and yeasts genomes and show that the most conserved subunits of eukaryotes among the nine subunits are CSN2 and CSN5. This may indicate a strong evolutionary selection for these two subunits. Despite the strong conservation of the protein sequence, the genomic structures of the intron/exon boundaries indicate no conservation at genomic level. This suggests that the gene structure is exposed to a much less selection compared with the protein sequence. We also show the conservation of important active domains, such as PCI (proteasome lid-CSN-initiation factor) and MPN (MPR1/PAD1 amino-terminal). We identified novel exons and alternative splicing variants for all CSN subunits. This indicates another level of complexity of the CSN. Notably, most COP9-subunits were identified in all multicellular and unicellular eukaryotic organisms analyzed, but not in prokaryotes or archaeas. Thus, genes encoding CSN subunits present in all analyzed eukaryotes indicate the invention of the signalosome at the root of eukaryotes. The identification of alternative splice variants indicates possible "mini-complexes" or COP9 complexes with independent subunits containing potentially novel and not yet identified functions. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  11. Fait saillant : Le CRDI à la 21e Conférence des Parties (COP21 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 avr. 2016 ... Le CRDI a assisté à la Conférence des Nations Unies sur les changements climatiques (COP21) du 30 novembre au 11 décembre 2015 à titre de membre de la délégation canadienne officielle. Plus de 20 de nos bénéficiaires de pays en développement ont fait part de leurs résultats de recherche lors ...

  12. Molecular characterization of a peanut variety and its derivatives based on SSR and COP analysis

    Institute of Scientific and Technical Information of China (English)

    Xiaoping REN; Boshou LIAO; Huifang JIANG; Zhongyuan YUAN; Yuning CHEN; Xiaojing ZHOU; Li HUANG; Jiaquan HUANG; Yong LEI; Liying YAN

    2016-01-01

    Despite the economic importance of the peanut,no studies have been carried out to determine the correlation between genetic distances based on molecular markers and on coefficient of parentage (COP) data.In this study,simple sequence repeat (SSR) and pedigree data were used to assess the genetic distance between the Fuhuasheng variety and its derivative cultivars.A total of 39 SSR polymorphism primers were used,and 151 bands were obtained,with an average of 2.04 bands in each primer.The genetic SSR-based distance (GD) values ranged from 0.02 to 0.81,while the COP-based GD ranged from 0.25 to 0.98.Certain Fuhuasheng loci displayed higher transmission rates.These loci or nearby chromosomal regions might be associated with desirable traits in Fuhuasheng variety,thus being frequently selected in breeding programs.Therefore,it can be suggested that COP analysis should be the preferred method for estimating genetic diversity invarieties with available complete pedigree information and parents.In this case,marker analysis would provide the best estimations.

  13. Monodispersepoly[BMA-co-(COPS-I)] Particles by Soap-Free Emulsion Copolymerization and Its Optical Properties as Photonic Crystals.

    Science.gov (United States)

    Lee, Ki Chang; Choo, Hun Seung

    2015-10-01

    In order to study the surfactant-free emulsion copolymerization of benzyl methacrylate (BMA) with sodium 1-allyloxy-2-hydroxypropane sulfonate (COPS-I) and the resulting optical properties, a series of experiments was carried out at various reaction conditions such as the changes of BMA concentration, COPS-I concentration, BMA concentration under a fixed COPS-I amount, initiator and divinyl benzene (DVB) concentration. All the latices showed highly monodispersed spherical particles in the size range of 144~435 nm and the respective shiny structural colors from their colloidal photonic crystals. It is found that the changes in such polymerization factors greatly affect the number of particles and particle diameter, polymerization rate, molecular weight, zeta-potential, and refractive indices. The increase of number of particles led to the increased rate of polymerization and zeta-potential of the latices, on the other hand, to the decreased molecular weight. Refractive indices and the reflectivity increased with COPS-I concentration, on the other hand, and decreased with DVB concentration. Especially, refractive indices of the resulting poly[BMA-co-(COPS-I)] colloidal photonic crystals showed much higher values of 1.65~2.21 than that of polystyrene, due to the formation of core-shell shaped morphology. Monodisperse and high refractive index of poly[BMA-co-(COPS-I)] particles prepared in this work could be used for the study in photonic crystals and electrophoretic display.

  14. Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts.

    Science.gov (United States)

    Rodríguez-Carpena, Javier-Germán; Morcuende, David; Petrón, María Jesus; Estévez, Mario

    2012-03-07

    The effect of phenolic-rich extracts from avocado peel on the formation of cholesterol oxidation products (COPs) in porcine patties subjected to cooking and chill storage was studied. Eight COPs (7α-hydroxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, 20α-hydroxycholesterol, 25-hydroxycholesterol, cholestanetriol, 5,6β-epoxycholesterol, and 5,6α-epoxycholesterol) were identified and quantified by GC-MS. The addition of avocado extracts (∼600 GAE/kg patty) to patties significantly inhibited the formation of COPs during cooking. Cooked control (C) patties contained a larger variety and greater amounts of COPs than the avocado-treated (T) counterparts. COPs sharply increased in cooked patties during the subsequent chilled storage. This increase was significantly higher in C patties than in the T patties. Interestingly, the amount of COPs in cooked and chilled T patties was similar to those found in cooked C patties. The mechanisms implicated in cholesterol oxidation in a processed meat product, the protective effect of avocado phenolics, and the potential implication of lipid and protein oxidation are thoroughly described in the present paper.

  15. Assessing the genetic diversity of Cu resistance in mine tailings through high-throughput recovery of full-length copA genes

    Science.gov (United States)

    Li, Xiaofang; Zhu, Yong-Guan; Shaban, Babak; Bruxner, Timothy J. C.; Bond, Philip L.; Huang, Longbin

    2015-01-01

    Characterizing the genetic diversity of microbial copper (Cu) resistance at the community level remains challenging, mainly due to the polymorphism of the core functional gene copA. In this study, a local BLASTN method using a copA database built in this study was developed to recover full-length putative copA sequences from an assembled tailings metagenome; these sequences were then screened for potentially functioning CopA using conserved metal-binding motifs, inferred by evolutionary trace analysis of CopA sequences from known Cu resistant microorganisms. In total, 99 putative copA sequences were recovered from the tailings metagenome, out of which 70 were found with high potential to be functioning in Cu resistance. Phylogenetic analysis of selected copA sequences detected in the tailings metagenome showed that topology of the copA phylogeny is largely congruent with that of the 16S-based phylogeny of the tailings microbial community obtained in our previous study, indicating that the development of copA diversity in the tailings might be mainly through vertical descent with few lateral gene transfer events. The method established here can be used to explore copA (and potentially other metal resistance genes) diversity in any metagenome and has the potential to exhaust the full-length gene sequences for downstream analyses. PMID:26286020

  16. CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts

    Directory of Open Access Journals (Sweden)

    Dong-Hee Kim

    2014-05-01

    Full Text Available Ultraviolet (UV exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1 activity. A 9-mer peptide, CopA3 (CopA3 was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.

  17. RFID Location Algorithm

    Directory of Open Access Journals (Sweden)

    Wang Zi Min

    2016-01-01

    Full Text Available With the development of social services, people’s living standards improve further requirements, there is an urgent need for a way to adapt to the complex situation of the new positioning technology. In recent years, RFID technology have a wide range of applications in all aspects of life and production, such as logistics tracking, car alarm, security and other items. The use of RFID technology to locate, it is a new direction in the eyes of the various research institutions and scholars. RFID positioning technology system stability, the error is small and low-cost advantages of its location algorithm is the focus of this study.This article analyzes the layers of RFID technology targeting methods and algorithms. First, RFID common several basic methods are introduced; Secondly, higher accuracy to political network location method; Finally, LANDMARC algorithm will be described. Through this it can be seen that advanced and efficient algorithms play an important role in increasing RFID positioning accuracy aspects.Finally, the algorithm of RFID location technology are summarized, pointing out the deficiencies in the algorithm, and put forward a follow-up study of the requirements, the vision of a better future RFID positioning technology.

  18. Le CRDI à la COP23 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En collaboration avec ses bénéficiaires et partenaires, le CRDI anime et participe à une série d'activités et d'événements durant la COP23, y compris des événements parallèles officiels de la CCNUCC et des groupes d'experts, des groupes de discussion, des ateliers et la 15e édition des Journées sur le développement et ...

  19. Electrodeposition of Nanocrystalline Co-P Coatings as a Hard Chrome Alternative (Briefing Charts)

    Science.gov (United States)

    2011-02-10

    chrome plating utilizes chromium in the hexavalent state (Cr6+) Cr6+ is a known carcinogen and poses a health risk to operators OSHA lowered the Cr6+ PEL...from 52 µg/m3 to 5 µg/m3 8 Apr 09, Memorandum, DoD Directive Hexavalent Chromium Management Policy NAVAIR Cr6+ Authorization Process Hard Chrome ...Aerospace & Defense February 10, 2011 Electrodeposition of Nanocrystalline Co-P Coatings as a Hard Chrome Alternative Jack Benfer Co-PI NAVAIR

  20. Heavy Metals Pollution of Alluvial Soil in the Copşa Mică Area

    OpenAIRE

    , D. Popa; , I.M. Prundeanu; , R. Lăcătuşu

    2011-01-01

    The objective of our study was to determine the concentrations of heavy metals (Cd, Cr, Co, Cu, Mn, Ni, Pb, Zn and Fe) from soil samples, which have been previously treated with HNO3 and concentrated HClO4. The study was performed on a series of 24 soil samples and one soil profile, collected from the alluvial soil in the Copşa Mică area. The concentrations of heavy metals were determined using Atomic Absorption Spectrometry. The pH was determined by using the potentiometric method in aqueous...

  1. Mapping of a Protective Epitope of the CopB Outer Membrane Protein of Moraxella catarrhalis

    OpenAIRE

    Aebi, Christoph; Cope, Leslie D.; Latimer, Jo L.; Thomas, Sharon E.; Slaughter, Clive A.; McCracken, George H.; Hansen, Eric J.

    1998-01-01

    A monoclonal antibody (MAb) (MAb 10F3) directed against the CopB outer membrane protein of Moraxella catarrhalis previously was found to enhance pulmonary clearance of M. catarrhalis in an animal model (M. Helminen, I. Maciver, J. L. Latimer, L. D. Cope, G. H. McCracken, Jr., and E. J. Hansen, Infect. Immun. 61:2003–2010, 1993). In the present study, this same MAb was shown to exert complement-dependent bactericidal activity against this pathogen in vitro. Nucleotide sequence analysis of the ...

  2. Law, Urban Violence and Order: Cop Shows as a Brazilian TV Genre

    OpenAIRE

    Luiza Lusvarghi

    2014-01-01

    A new type of Brazilian drama series has taken place on local  TV -  the cop shows. Although they are not popular as the telenovela (soap operas), definitively they came to stay.  International channels like Fox and HBO are benefited by Tax Benefits Rule which provides financial conditions for the production of those home market, and are now competing with the two greatest media Brazilian  groups – Record and Globo.  The worldwide success of “Cidade de Deus” (City of God, 2002, Fernando Meire...

  3. ClimasCOPe: Exploring the challenges behind the Paris Agreement - COP21

    International Nuclear Information System (INIS)

    Leguet, Benoit; Alberola, Emilie; Afriat, Marion; Vaidyula, Manasvini; Morel, Romain; Cochran, Ian; Deheza, Mariana; Shishlov, Igor; Leseur, Alexia; Depoues, Vivian; Bordier, Cecile; Bultheel, Clement; Bellassen, Valentin

    2015-04-01

    In the framework of the 21. Conference of the Parties (COP21) to the United Nations Framework Convention on Climate Change (UNFCCC), held in Paris from November 30 to December 11 2015, I4CE - Institute for Climate Economics, in partnership with ADEME, the French Environment and Energy Management Agency, attempts to shed some light on the challenges surrounding this Paris Climate Conference 2015. They explore what can be expected from the post-2020 climate agreement in Paris. They also discuss some keys success indicators of such an agreement. Over the course of six issues, ClimasCOPe provides analysis related to carbon pricing, climate finance, greenhouse gas (GHG) emissions' accounting, the role of sub-national actors, adaptation to climate change and the compatibility of government commitments with the scenario where in global mean temperatures would rise by no more than 2 deg. C. Issue 1 - Carbon pricing: a necessary tool on the agenda of solutions for climate funding (Putting a Price on Carbon, First submissions of intended Nationally Determined Contributions for Paris Agreement, 5 carbon pricing initiatives); Issue 2 - Financing the low-carbon transition: the need for coherence between regulations and ambition (Finance will be the cornerstone of the Paris accord, News, 5 initiatives for Climate Finance); Issue 3 - Three keys to effective GHG emissions monitoring for a broader climate agreement (MRV: how to hit the bull's eye when there is no silver bullet? First Climate Week and the Bonn negotiations, 3 MRV initiatives); Issue 4 - Non-state actors: pushing the climate action agenda forward (The role of cities and regions and their knock-on effects, G7 announcements and the process of adopting the SDGs, 4 non-state actor initiatives); Issue 5 - COP 21: a new approach and the launch of a process to address climate change adaptation (Adapting to climate change: taking ownership of the issues and removing barriers to implementation, First COP 21 draft

  4. Magnetic properties of CoP alloys electrodeposited at room temperature

    International Nuclear Information System (INIS)

    Lucas, I.; Perez, L.; Aroca, C.; Sanchez, P.; Lopez, E.; Sanchez, M.C.

    2005-01-01

    CoP alloys have been electrodeposited at room temperature from electrolytes with different pH values and their magnetic properties have been studied. Cracks and fractures appear when using stiff substrates, showing that high internal stresses, due to hydrogen evolution, are involved in the electrodeposition process. Samples electrodeposited onto flexible substrates do not show cracks on the surface. We also report an increment in the coercivity of the alloys when the pH of the electrolyte decreases, and therefore, the hydrogen evolution and the internal stresses increase

  5. COP15 for journalists: a guide to the UN climate change summit

    Energy Technology Data Exchange (ETDEWEB)

    Shanahan, Mike

    2009-11-15

    Governments gather in Denmark in December 2009 for what is perhaps the most important meeting since the end of the second world war. December is the deadline they have set themselves for agreeing on action to tackle climate change, and the COP15 conference in Copenhagen is where hopes are high that a new global deal can be struck. This briefing is a guide for journalists reporting on this event, its buildup and its aftermath. It explains key processes, major actions to be agreed and possible outcomes.

  6. New, Improved Version of the mCOP-PCR Screening System for Detection of Spinal Muscular Atrophy Gene (SMN1) Deletion.

    Science.gov (United States)

    Shinohara, Masakazu; Ar Rochmah, Mawaddah; Nakanishi, Kenta; Harahap, Nur Imma Fatimah; Niba, Emma Tabe Eko; Saito, Toshio; Saito, Kayoko; Takeuchi, Atsuko; Bouike, Yoshihiro; Nishio, Hisahide

    2017-09-07

    Spinal muscular atrophy (SMA) is a frequent autosomal recessive disorder, characterized by lower motor neuron loss in the spinal cord. More than 95% of SMA patients show homozygous survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique. However, non-specific amplification products were observed with mCOP-PCR, which might lead to erroneous interpretation of the screening results. To establish an improved version of the mCOP-PCR screening system without non-specific amplification. DNA samples were assayed using a new version of the mCOP-PCR screening system. DNA samples had already been genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP), showing the presence or absence of SMN1 exon 7. The new mCOP-PCR method contained a targeted pre-amplification step of the region, including an SMN1-specific nucleotide, prior to the mCOP-PCR step. mCOP-PCR products were electrophoresed on agarose gels. No non-specific amplification products were detected in electrophoresis gels with the new mCOP-PCR screening system. An additional targeted pre-amplification step eliminated non-specific amplification from mCOP-PCR screening.

  7. Experimental study of a thermoelectrically-driven liquid chiller in terms of COP and cooling down period

    International Nuclear Information System (INIS)

    Faraji, Amir Yadollah; Goldsmid, H.J.; Akbarzadeh, Aliakbar

    2014-01-01

    Highlights: • A COP of 0.8 is achievable for a thermoelectrically-driven water chiller. • With two market available TEC modules with ZT around 0.7 sub-zero temperatures became applicable. • Forced air convection heat exchangers have better COP and CDP compared with natural convection. • A PID controller has several advantages against on–off controller for controlling TEC module. - Abstract: To study COP and other cooling parameters of a thermoelectically-driven liquid chiller, a 430 ml capacity liquid chiller incorporating two commercially available thermoelectric modules as its active components, has been designed, built and assessed. The system can use natural or forced air convection in heat exchangers attached to the thermoelectric module surfaces. The coefficient of performance (COP) and cooling down period (CDP) of the system for different thermoelectric input voltages have been measured. The COP of the thermoelectric chiller was found to be in the range 0.2–1.4 for forced convection and 0.2–1 for natural convection at a cooled liquid temperature of 10 °C and an ambient temperature of 18 °C. For the chiller, heat pumping capacity, minimum achievable water temperature, and temperature difference across the thermoelectric surfaces were investigated for input voltages of 3 V, 5 V, 7 V, 10 V and 12 V. Furthermore, as a basis for reliable and convenient control of the chiller, a proportional integral derivative (PID) controller has been proposed

  8. SmartCop: Enabling Smart Traffic Violations Ticketing in Vehicular Named Data Networks

    Directory of Open Access Journals (Sweden)

    Syed Hassan Ahmed

    2016-01-01

    Full Text Available Recently, various applications for Vehicular Ad hoc Networks (VANETs have been proposed and smart traffic violation ticketing is one of them. On the other hand, the new Information-Centric Networking (ICN architectures have emerged and been investigated into VANETs, such as Vehicular Named Data Networking (VNDN. However, the existing applications in VANETs are not suitable for VNDN paradigm due to the dependency on a “named content” instead of a current “host-centric” approach. Thus, we need to design the emerging and new architectures for VNDN applications. In this paper, we propose a smart traffic violation ticketing (TVT system for VNDN, named as SmartCop, that enables a cop vehicle (CV to issue tickets for traffic violation(s to the offender(s autonomously, once they are in the transmission range of that CV. The ticket issuing delay, messaging cost, and percentage of violations detected for varying number of vehicles, violators, CVs, and vehicles speeds are estimated through simulations. In addition, we provide a road map of future research directions for enabling safe driving experience in future cars aided with VNDN technology.

  9. Kyoto protocol and related issues; Chikyu ondanka boshi Kyoto kaigi (COP3) to sono kadai

    Energy Technology Data Exchange (ETDEWEB)

    Ninomiya, Y. [Global Industrial Social Progress Research Institute, Tokyo (Japan)

    1997-09-30

    The Third Session of the Conference of the Parties to the United Nations Framework Convention on Climate Change (COP3) will be held in Kyoto in December 1997. Described herein are the current status and issues of the convention. USA and Japan, which hold important keys to set up the abatement target, have issued no proposals concretely at the current AGBM (Ad-hoc Group Berlin Mandate) 7, and the conference for the concrete targets will be decided in the next AGBM 8 to be held in October. The final target will be set by the ministerial segment of COP3, because the negotiations for the treaty are political in nature. USA proposes reduction at a uniform, realistic rate, and Japan proposes reduction at a uniform rate or setting up the emission target per capita, each being different from reduction at a much higher uniform rate proposed by EU. Within EU, however, 10% out of 15% reduction rate it proposes is agreed by the member countries, and the remaining rate of % may not be agreed. It is necessary for the advanced parties to set up realistic and legally binding solutions, including ratification by USA, which can persuade the developing countries. tab.1

  10. COP improvement of refrigerator/freezers, air-conditioners, and heat pumps using nonazeotropic refrigerant mixtures

    Science.gov (United States)

    Westra, Douglas G.

    1993-01-01

    With the February, 1992 announcement by President Bush to move the deadline for outlawing CFC (chloro-fluoro-carbon) refrigerants from the year 2000 to the year 1996, the refrigeration and air-conditioning industries have been accelerating their efforts to find alternative refrigerants. Many of the alternative refrigerants being evaluated require synthetic lubricants, are less efficient, and have toxicity problems. One option to developing new, alternative refrigerants is to combine existing non-CFC refrigerants to form a nonazeotropic mixture, with the concentration optimized for the given application so that system COP (Coefficient Of Performance) may be maintained or even improved. This paper will discuss the dilemma that industry is facing regarding CFC phase-out and the problems associated with CFC alternatives presently under development. A definition of nonazeotropic mixtures will be provided, and the characteristics and COP benefits of nonazeotropic refrigerant mixtures will be explained using thermodynamic principles. Limitations and disadvantages of nonazeotropic mixtures will be discussed, and example systems using such mixtures will be reviewed.

  11. Simulation of Organic Matter and Pollutant Evolution during Composting: The COP-Compost Model.

    Science.gov (United States)

    Lashermes, G; Zhang, Y; Houot, S; Steyer, J P; Patureau, D; Barriuso, E; Garnier, P

    2013-01-01

    Organic pollutants (OPs) are potentially present in composts and the assessment of their content and bioaccessibility in these composts is of paramount importance. In this work, we proposed a model to simulate the behavior of OPs and the dynamic of organic C during composting. This model, named COP-Compost, includes two modules. An existing organic C module is based on the biochemical composition of the initial waste mixture and simulates the organic matter transformation during composting. An additional OP module simulates OP mineralization and the evolution of its bioaccessibility. Coupling hypotheses were proposed to describe the interactions between organic C and OP modules. The organic C module, evaluated using experimental data obtained from 4-L composting pilots, was independently tested. The COP-Compost model was evaluated during composting experiments containing four OPs representative of the major pollutants detected in compost and targeted by current and future regulations. These OPs included a polycyclic aromatic hydrocarbon (fluoranthene), two surfactants (4--nonylphenol and a linear alkylbenzene sulfonate), and an herbicide (glyphosate). Residues of C-labeled OP with different bioaccessibility were characterized by sequential extraction and quantified as soluble, sorbed, and nonextractable fractions. The model was calibrated and coupling the organic C and OP modules improved the simulation of the OP behavior and bioaccessibility during composting. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  12. Friction Stir Welding of GR-Cop 84 for Combustion Chamber Liners

    Science.gov (United States)

    Russell, Carolyn K.; Carter, Robert; Ellis, David L.; Goudy, Richard

    2004-01-01

    GRCop-84 is a copper-chromium-niobium alloy developed by the Glenn Research Center for liquid rocket engine combustion chamber liners. GRCop-84 exhibits superior properties over conventional copper-base alloys in a liquid hydrogen-oxygen operating environment. The Next Generation Launch Technology program has funded a program to demonstrate scale-up production capabilities of GR-Cop 84 to levels suitable for main combustion chamber production for the prototype rocket engine. This paper describes a novel method of manufacturing the main combustion chamber liner. The process consists of several steps: extrude the GR-Cop 84 powder into billets, roll the billets into plates, bump form the plates into cylinder halves and friction stir weld the halves into a cylinder. The cylinder is then metal spun formed to near net liner dimensions followed by finish machining to the final configuration. This paper describes the friction stir weld process development including tooling and non-destructive inspection techniques, culminating in the successful production of a liner preform completed through spin forming.

  13. Breakdown conditioning of copper, CuZr and GlidCop® : effect of mechanical surface treatments

    CERN Document Server

    Ramsvik, T; Calatroni, S; Taborelli, M; CERN. Geneva. TS Department

    2007-01-01

    Motivated by the need of novel materials for the CLIC accelerating structures to resist mechanical fatigue, the copper based metals Copper Zirconium C15000 (CuZr) and GlidCop® Al-15 C15715 have been investigated by DC breakdown measurements, and compared with commercially pure Oxygen-free Copper C10100 (Cu-OFE). In all three cases the saturated breakdown fields (Esat) are similar, despite significant differences in their tensile strengths. In addition, the choice of mechanical surface preparation techniques influences the final breakdown characteristics. For both CuZr and GlidCop® immediate conditioning takes place when the surfaces are prepared by milling. For electro discharge machined (EDM) surfaces, however, several breakdown events are needed to obtain saturation. Specifically, for EDM treated CuZr and GlidCop®, ~50 and ~200 breakdown events are required to reach Esat.

  14. Assessing control of postural stability in community-living older adults using performance-based limits of stability

    Directory of Open Access Journals (Sweden)

    Boissy Patrick

    2008-03-01

    Full Text Available Abstract Background Balance disability measurements routinely used to identify fall risks in frail populations have limited value in the early detection of postural stability deficits in community-living older adults. The objectives of the study were to 1 measure performance-based limits of stability (LOS in community-living older adults and compare them to theoretical LOS computed from data proposed by the Balance Master® system, 2 explore the feasibility of a new measurement approach based on the assessment of postural stability during weight-shifting tasks at performance-based LOS, 3 quantify intra-session performance variability during multiple trials using the performance-based LOS paradigm. Methods Twenty-four healthy community-living older adults (10 men, 14 women aged between 62 to 85 (mean age ± sd, 71.5 ± 6 yrs participated in the study. Subjects' performance-based LOS were established by asking them to transfer their body weight as far as possible in three directions (forward, right and left without changing their base of support. LOS were computed as the maximal excursion of the COP in each direction among three trials. Participants then performed two experimental tasks that consisted in controlling, with the assistance of visual feedback, their centre of pressure (COP within two predefined targets set at 100% of their performance-based LOS. For each tasks 8 trials were performed. Ground reaction forces and torques during performance-based LOS evaluation and experimental tasks were recorded with a force plate. Sway area and medio-lateral mean COP displacement speed variables were extracted from force plate recordings. Results Significant differences between theoretical LOS computed from maximum leaning angles derived from anthropometric characteristics and performance-based LOS were observed. Results showed that a motor learning effect was present as the participants optimized their weight-shifting strategy through the first three

  15. Evaluation of intrinsic groundwater vulnerability to pollution: COP method for pilot area of Carrara hydrogeological system (Northern Tuscany, Italy)

    Science.gov (United States)

    Baldi, B.; Guastaldi, E.; Rossetto, R.

    2009-04-01

    During the characterization of the Apuan Alps groundwater body ( "Corpo Idrico Sotterraneo Significativo", briefly CISS) (Regione Toscana, 2007) the intrinsic vulnerability has been evaluated for Carrara hydrogeological system (Northern Tuscany, Italy) by means of COP method, developed within COST 620 European Action (Zwalhlen, 2003). This system is both characterized by large data availability and it is considered an highly risky zone since groundwater protection problems (turbidity of the tapped spring waters and hydrocarbons contamination) and anthropic activity (marble quarries). The study area, 20 Km2large, has high relief energy, with elevations ranging from 5 to 1700 m amsl in almost 5 km. Runoff is scarce except during heavy rainfall; due to the presence of carbonate rocks infiltration is high: groundwater discharge at 155-255 m amsl. The area is located in the north-western part of Apuan Alps Metamorphic Complex, characterized by carbonate and non-carbonate rocks belonging to the non-metamorphic Tuscan Units (Carnic-Oligocene), Mesozoic Succession, Middle-Triassic Succession, and metamorphic Paleozoic rocks. The main geological structure of the area is the Carrara Syncline, constituted prevalently by dolostones, marbles and cherty limestones. These carbonate formations define several moderately to highly productive hydrogeological units, characterized by fissured and karst flow. Hydrogeological system may be subdivided in two different subsets, because of both geo-structural set up and area conformation. However, these are hydrogeologically connected since anisotropy and fractures of karst groundwater. The southern boundary of Carrara hydrogeological system shows important dammed springs, defined by low productive units of Massa Unit (Cambriano?-Carnic). COP methodology for evaluating intrinsic vulnerability of karst groundwater is based on three main factors for the definition of vulnerability itself: COPIndex = C (flow Concentration) *O (Overlying layers

  16. 30 CFR 285.700 - What reports must I submit to MMS before installing facilities described in my approved SAP, COP...

    Science.gov (United States)

    2010-07-01

    ... installing facilities described in my approved SAP, COP, or GAP? 285.700 Section 285.700 Mineral Resources... § 285.700 What reports must I submit to MMS before installing facilities described in my approved SAP... in your approved COP (§ 285.632(a)) and, when required by this part, your SAP (§ 285.614(b)) or GAP...

  17. BIODEGRADACIÓN DE COMPUESTOS ORGÁNICOSPERSISTENTES (COP: I. EL CASO DE LOS BIFENILOSPOLICLORADOS (PCB

    Directory of Open Access Journals (Sweden)

    ZIV ARBELI

    2009-01-01

    Full Text Available RESUMEN Los contaminantes orgánicos persistentes poseen propiedades tóxicas, son resistentes a la degradación, se bioacumulan y son transportados por el aire, el agua y las especies migratorias a través de las fronteras internacionales; en consecuencia se depositan lejos del lugar de su liberación, acumulándose en ecosistemas terrestres y acuáticos. Para atender a esta problemática a nivel mundial se firmó el 23 de mayo de 2001 el Convenio de Estocolmo. Aunque por ahora los COP estan prohibidos en la mayoria de los países, todavía existen en el mundo muchos sitios contaminados con estas sustancias. La remediación de sitios que presentan contaminantes orgánicos persistentes requiere consideraciones distintas a las contempladas en la recupe-ración por contaminación de hidrocarburos. El siguiente texto revisa la literatura sobre la biodegradación anaeróbica y aeróbica de los bifeniles policlorados (PCB y las posibles estrategias para estimular dicha biodegradación. La degradación de los demás COP será descritas en textos adicionales. Palabras clave: contaminantes orgánicos persistentes (COP; bifeniles policlorados (PCB; biodegradación; biorremediación. ABSTRACT Persistent organic pollutants are chemicals that are toxic to humans and wildlife, remain intact in the environment for long periods, accumulate in living organisms and can become widely distributed geographically by air, water or migrating species. As a result, these contaminants have been found all over the world including in places, such as the Polar Regions, which are very far from their application site. The Stockholm Convention was signed in 23/5/01 in order to cope with this international environmental problem. Although POPs were banned by most countries, there are still a lot of sites contaminated with these substances. The remediation of these sites is problematic and requires distinct considerations from those which are established for hydrocarbon

  18. Discursos e vozes na cobertura jornalística das COP15 e 16

    Directory of Open Access Journals (Sweden)

    Ilza Maria Tourinho Girardi

    2013-12-01

    Full Text Available O texto apresenta um exercício de análise da cobertura das Conferências da ONU sobre Mudanças Climáticas, COP 15 e 16, em revistas brasileiras e portuguesas publicadas em 2009 e 2010. Examina como foi construído o discurso sobre sustentabilidade e quais foram as vozes acionadas. Por meio da leitura produzida, teórica e metodologicamente baseada na análise do discurso e das fontes, foi possível evidenciar a predominância de um discurso ecotecnocrático e a opção privilegiada por fontes dos campos político e econômico

  19. Copépodos parásitos en Genypterus blacodes (Osteichtes

    Directory of Open Access Journals (Sweden)

    Paulina Donoso.

    2017-01-01

    Full Text Available Los peces del género Genypterus son un recurso importante en la industria pesquera, y estos se encuentran expuestos a una serie de ectoparásitos, entre los se encuentran los copépodos los cuales pueden ser muy específicos en sus hospedederos. Una de las especies parásitas corresponde a Sphyrium laevigatum el cual parasita además tres especies de importancia económica en las pesquerías locales chilenas. Se discuten en el presente trabajo la situación de S. laevigatum en G. blacodes, así como aspectos ecológicos y biogeográficos.

  20. THE EFFECT OF HIGH OVERVOLTAGES AT ELECTROCRYSTALLIZATION ON THE CORROSION RESISTANCE OF THE FILMS CO-P

    Directory of Open Access Journals (Sweden)

    V. O. Zabludovskyi

    2009-03-01

    Full Text Available Electrochemical and gravimetric methods are used in order to research the influence of high overvoltages during electroplating on corrosive and electrochemical behavior of amorphous Co-P films, which were made using deposition from water solution of an electrolyte. It is obtained that alloys, which were plated using higher overvoltages on cathode, are more corrosion-resistant.

  1. COP21 - A moment of truth for climate and sustainable development

    International Nuclear Information System (INIS)

    2015-01-01

    Time is running out to act on climate change, poverty eradication and sustainable development. These challenges cannot be met independently of each other. The task of COP21 is to send strong policy signals that determined climate action is needed and will not harm the economy. In fact, these actions will trigger multiple employment, health and human development benefits by aligning strengthened short-term economic growth with long-term sustainable development goals. It is challenging but possible to trigger the transformation toward low carbon futures and to increase the affordability of advanced technologies despite the current pressures on public budgets. The world is awash in liquidity. What is needed is to redirect the savings of households, pension funds, insurance schemes, and sovereign wealth funds towards long-term and low-carbon investments. Sound regulatory frameworks and innovative financial mechanisms must be established to reduce the risks attached to potentially profitable low-carbon projects that are blocked by a combination of high up front costs and an uncertain environment, so as to attract private savings and institutional investors. COP 21 can provide critical policy hooks for step changes in economic and financial inter-mediation based on public guarantees for low carbon investments; an agreed social value of carbon mitigation activities could be incorporated into diverse low-carbon financial initiatives supporting Intended Nationally Determined Contributions (INDCs); strong and enforceable requirements for Measuring, Reporting and Verification (MRV) can ensure the environmental integrity and sustainability of the resulting investments. Such a framework can secure the transparency of voluntary commitments by countries, clubs of countries and non-state actors. If it can achieve these goals, the Paris Agreement can unleash a wave of investments into low-carbon development that responds to short-term economic and social challenges while supporting

  2. The promiscuous phosphomonoestearase activity of Archaeoglobus fulgidus CopA, a thermophilic Cu+ transport ATPase.

    Science.gov (United States)

    Bredeston, Luis M; González Flecha, F Luis

    2016-07-01

    Membrane transport P-type ATPases display two characteristic enzymatic activities: a principal ATPase activity provides the driving force for ion transport across biological membranes, whereas a promiscuous secondary activity catalyzes the hydrolysis of phosphate monoesters. This last activity is usually denoted as the phosphatase activity of P-ATPases. In the present study, we characterize the phosphatase activity of the Cu(+)-transport ATPase from Archaeglobus fulgidus (Af-CopA) and compare it with the principal ATPase activity. Our results show that the phosphatase turnover number was 20 times higher than that corresponding to the ATPase activity, but it is compensated by a high value of Km, producing a less efficient catalysis for pNPP. This secondary activity is enhanced by Mg(2+) (essential activator) and phospholipids (non-essential activator), and inhibited by salts and Cu(+). Transition state analysis of the catalyzed and noncatalyzed hydrolysis of pNPP indicates that Af-CopA enhances the reaction rates by a factor of 10(5) (ΔΔG(‡)=38 kJ/mol) mainly by reducing the enthalpy of activation (ΔΔH(‡)=30 kJ/mol), whereas the entropy of activation is less negative on the enzyme than in solution. For the ATPase activity, the decrease in the enthalpic component of the barrier is higher (ΔΔH(‡)=39 kJ/mol) and the entropic component is small on both the enzyme and in solution. These results suggest that different mechanisms are involved in the transference of the phosphoryl group of p-nitrophenyl phosphate and ATP. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Actualizing Communities of Practice (COPs and Situated Learning for A Sustainable Eco-Village

    Directory of Open Access Journals (Sweden)

    Maria Victoria Pineda

    2016-05-01

    Full Text Available An eco-village as defined by Robert Gilman is a “human-scale, full-featured settlement where you feel you know the others, and human activities are integrated with natural, biological systems.” Roland Mayerl argued that this maybe ideal, but there are huge challenges. He claims the challenges are at different levels—there is the physical layer that constitutes food production, animals, water and wastewater treatment. Other layers will be the built environment, the economic system and the governance in the village.This paper argues that one of the challenging layers is the human layer that was excluded in the modeling of many eco-village works. While there are many good models of an eco-village, sustainability will primarily be laid on the shoulders of the members of the community or the village for that matter. Sustainability should be espoused by the members of the eco-village. But how can sustainability be attained? What sustainability approach or strategy can be employed?“Communities of practice (COP are formed by people who engage in a process of collective learning in a shared domain of human endeavor.“ (Wenger, 2004 COPs are concepts commonly applied in organizations and virtual communities. Using this approach together with periphery participation and situated learning, this paper presents a human-based model of a sustainable eco-village and some useful examples.The paper also argues that an eco-village necessitates the support of technology in enhancing and preserving the shared practices. Hence, use of social media deployed in the web is one of the recommended ways that also permit collective action among members of the eco-village.

  4. SMA Diagnosis: Detection of SMN1 Deletion with Real-Time mCOP-PCR System Using Fresh Blood DNA.

    Science.gov (United States)

    Niba, Emma Tabe Eko; Ar Rochmah, Mawaddah; Harahap, Nur Imma Fatimah; Awano, Hiroyuki; Morioka, Ichiro; Iijima, Kazumoto; Saito, Toshio; Saito, Kayoko; Takeuchi, Atsuko; Lai, Poh San; Bouike, Yoshihiro; Nishio, Hisahide; Shinohara, Masakazu

    2017-12-18

    Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders. The symptoms are caused by defects of lower motor neurons in the spinal cord. More than 95% of SMA patients are homozygous for survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique using dried blood spot (DBS) on filter paper. This system is convenient for mass screening in the large population and/or first-tier diagnostic method of the patients in the remote areas. However, this system was still time-consuming and effort-taking, because it required pre-amplification procedure to avoid non-specific amplification and gel-electrophoresis to detect the presence or absence of SMN1 deletion. When the fresh blood samples are used instead of DBS, or when the gel-electrophoresis is replaced by real-time PCR, we may have a simpler and more rapid diagnostic method for SMA. To establish a simpler and more rapid diagnostic method of SMN1 deletion using fresh blood DNA. DNA samples extracted from fresh blood and stored at 4 ℃ for 1 month. The samples were assayed using a real-time mCOP-PCR system without pre-amplification procedures. DNA samples had already been genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP), showing the presence or absence of SMN1 exon 7. The DNA samples were directly subjected to the mCOP-PCR step. The amplification of mCOP-PCR was monitored in a real-time PCR apparatus. The genotyping results of the real-time mCOP-PCR system using fresh blood DNA were completely matched with those of PCR-RFLP. In this real-time mCOP-PCR system using fresh blood-DNA, it took only four hours from extraction of DNA to detection of the presence or absence of SMN1 deletion, while it took more than 12 hours in PCR-RFLP. Our real-time mCOP-PCR system using fresh blood DNA was rapid and accurate, suggesting it may be useful for the first

  5. Analysis of the role of COP9 Signalosome (CSN subunits in K562; the first link between CSN and autophagy

    Directory of Open Access Journals (Sweden)

    Bunce Christopher M

    2009-04-01

    Full Text Available Abstract Background The COP9/signalosome (CSN is a highly conserved eight subunit complex that, by deneddylating cullins in cullin-based E3 ubiquitin ligases, regulates protein degradation. Although studied in model human cell lines such as HeLa, very little is known about the role of the CSN in haemopoietic cells. Results Greater than 95% knockdown of the non-catalytic subunit CSN2 and the deneddylating subunit CSN5 of the CSN was achieved in the human myeloid progenitor cell line K562. CSN2 knockdown led to a reduction of both CSN5 protein and mRNA whilst CSN5 knockdown had little effect on CSN2. Both knockdowns inhibited CSN deneddylase function as demonstrated by accumulation of neddylated Cul1. Furthermore, both knockdowns resulted in the sequential loss of Skp2, Cdc4 and β-TrCP F-box proteins. These proteins were rescued by the proteasome inhibitor MG132, indicating the autocatalytic degradation of F-box proteins upon loss of CSN2 or CSN5. Interestingly, altered F-box protein gene expression was also observed in CSN2 and CSN5 knockdowns, suggesting a potential role of the CSN in regulating F-box protein transcription. Loss of either CSN subunit dramatically reduced cell growth but resulted in distinct patterns of cell death. CSN5 knockdown caused mitotic defects, G2/M arrest and apoptotic cell death. CSN2 knockdown resulted in non-apoptotic cell death associated with accumulation of both the autophagy marker LC3-II and autophagic vacuoles. Treatment of vector control K562 cells with the autophagy inhibitors 3-methyladenine and bafilomycin A1 recapitulated the growth kinetics, vacuolar morphology and LC3-II accumulation of CSN2 knockdown cells indicating that the cellular phenotype of CSN2 cells arises from autophagy inhibition. Finally, loss of CSN2 was associated with the formation of a CSN5 containing subcomplex. Conclusion We conclude that CSN2 is required for CSN integrity and the stability of individual CSN subunits, and postulate

  6. Fingertip touch improves postural stability in patients with peripheral neuropathy.

    Science.gov (United States)

    Dickstein, R; Shupert, C L; Horak, F B

    2001-12-01

    The purpose of this work was to determine whether fingertip touch on a stable surface could improve postural stability during stance in subjects with somatosensory loss in the feet from diabetic peripheral neuropathy. The contribution of fingertip touch to postural stability was determined by comparing postural sway in three touch conditions (light, heavy and none) in eight patients and eight healthy control subjects who stood on two surfaces (firm or foam) with eyes open or closed. In the light touch condition, fingertip touch provided only somatosensory information because subjects exerted less than 1 N of force with their fingertip to a force plate, mounted on a vertical support. In the heavy touch condition, mechanical support was available because subjects transmitted as much force to the force plate as they wished. In the no touch condition, subjects held the right forefinger above the force plate. Antero-posterior (AP) and medio-lateral (ML) root mean square (RMS) of center of pressure (CoP) sway and trunk velocity were larger in subjects with somatosensory loss than in control subjects, especially when standing on the foam surface. The effects of light and heavy touch were similar in the somatosensory loss and control groups. Fingertip somatosensory input through light touch attenuated both AP and ML trunk velocity as much as heavy touch. Light touch also reduced CoP sway compared to no touch, although the decrease in CoP sway was less effective than with heavy touch, particularly on the foam surface. The forces that were applied to the touch plate during light touch preceded movements of the CoP, lending support to the suggestion of a feedforward mechanism in which fingertip inputs trigger the activation of postural muscles for controlling body sway. These results have clinical implications for understanding how patients with peripheral neuropathy may benefit from a cane for postural stability in stance.

  7. Statistical analysis of dust signals observed by ROSINA/COPS onboard of the Rosetta spacecraft at comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Tzou, Chia-Yu; altwegg, kathrin; Bieler, Andre; Calmonte, Ursina; Gasc, Sébastien; Le Roy, Léna; Rubin, Martin

    2016-10-01

    ROSINA is the in situ Rosetta Orbiter Spectrometer for Ion and Neutral Analysis on board of Rosetta, one of the corner stone missions of the European Space Agency (ESA) to land and orbit the Jupiter family comet 67P/Churyumov-Gerasimenko (67P). ROSINA consists of two mass spectrometers and a pressure sensor. The Reflectron Time of Flight Spectrometer (RTOF) and the Double Focusing Mass Spectrometer (DFMS) complement each other in mass and time resolution.The Comet Pressure Sensor (COPS) provides density measurements of the neutral molecules in the cometary coma of 67P. COPS has two gauges, a nude gauge that measures the total neutral density and a ram gauge that measures the dynamic pressure from the comet. Combining the two COPS is also capable of providing gas dynamic information such as gas velocity and gas temperature of the coma.While Rosetta started orbiting around 67P in August 2014, COPS observed diurnal and seasonal variations of the neutral gas density in the coma. Surprisingly, additional to these major density variation patterns, COPS occasionally observed small spikes in the density that are associated with dust. These dust signals can be interpreted as a result of cometary dust releasing volatiles while heated up near COPS. A statistical analysis of dust signals detected by COPS will be presented.

  8. Avances en la exposición contable de CoPs y memorias GRI = Advances in CoPs and GRI reports as accounting statements

    Directory of Open Access Journals (Sweden)

    Liliana Fernández Lorenzo

    2012-07-01

    Full Text Available Actualmente para lograr un desarrollo sustentable, la sociedad requiere que las organizaciones asuman su responsabilidad socio-ambiental y emitan información acerca de los impactos que su actividad genera en el medioambiente.Dicha información mayormente se presenta a través de las denominadas Memorias o Reportes de Sostenibilidad, que responden a distintas formas y contenidos. Cada vez son más los informes que se elaboran siguiendo los lineamientos del Pacto Mundial (PM y del Global Reporting Initiative (GRI.Consideramos que la información sobre la responsabilidad socio-ambiental debería reunir los requisitos que hacen a toda buena información contable, para incrementar su utilidad.Para comprobarlo, se realiza un estudio de casos a los fines de determinar las características generales de estos informes elaborados bajo pautas del PM y del GRI conjuntamente, concluyendo que la información presentada en las memorias analizadas no reúne los requisitos de una buena información contable.A fin de que la exposición de las CoPs y memorias de sostenibilidad GRI, pueda calificarse de contable, se expresan sintéticamente los indicadores analizados agregando su relación porcentual y se incorporan al Estado Contable Socio-ambiental realizado de acuerdo al modelo base de la FCE-UNLP, considerado como un estado contable (Fernández Lorenzo y Geba, 2008.Nowadays in order to achieve sustainable development, organizations are required to take on their social and environmental responsibility and give information about the impact of their activities in the environment.This information is usually presented through sustainability reports, which widely differ in content and layout. Many organizations worldwide have assumed their responsibility by implementing Global Reporting Initiative (GRI and United Nations Global Compact (GC guidelines.We consider that the information regarding socio-environmental responsibility, should meet the characteristics of the

  9. Relation between knee extensors' strength, postural stability and variability of centre of pressure displacement during gait in adult women

    Directory of Open Access Journals (Sweden)

    Eliza C. de Souza

    2017-03-01

    Full Text Available Background: It has been shown that variability of walking is related to fall risk similarly as postural control and muscle strength. Joint potential of this group of variables for fall risk assessment is promising, however research interested in relations between them is lacking. Objective: The aim of this study was to investigate the relation between knee extensors' strength, centre of pressure (COP velocity during one-leg stance and variability of COP displacement during various phases of gait cycle in middle-age women. Methods: A single group of 40 healthy women (age 56 ± 4.2 years took part in the study. For assessment of knee extensors' strength (peak torque and average work during concentric and eccentric contractions an isokinetic dynamometer was used. Mean velocity of COP during one-leg stance in anterior-posterior (AP and medial-lateral (ML directions was assessed on a force plate on a rigid surface with eyes open (two 30 s trials. Variability of COP displacement was assessed for loading response, midstance, terminal stance and preswing gait cycle phases (determined by vertical ground reaction force in AP and ML directions. It was measured by two force plates positioned in the middle of an 8 m walkway (5 trials at a self-selected speed. For statistical analysis of relationships between variables Pearson correlation was applied. Results: Our results showed significant correlations between eccentric peak torque and COP velocity in AP direction during one-leg stance, eccentric and concentric peak torque and COP variability during loading response in both ML and AP directions and during terminal stance in AP direction. Conclusion: Loading response and terminal stance seems to be more related to knee extensors' strength. Variables derived from postural stability assessment during one-leg stance are independent from variables derived from assessment of COP displacement variability during walking.

  10. COP 15 'Climate Change Conference Copenhagen and beyond'. Report of a NeVER meeting; COP 15 'Climate Change Conference Copenhagen and beyond'. Verslag bijeenkomst NeVER

    Energy Technology Data Exchange (ETDEWEB)

    Duindam, R.H.; Van EEuwen, M.P. [Cluster Energie en Vervoer, Juridische Dienst, Nederlandse Mededingingsautoriteit NMa, Den Haag (Netherlands)

    2010-08-15

    Report of a meeting of NeVER (the Dutch Energy Law Association) on 8 February 2010 at the Dutch Competition Authority in The Hague, the Netherlands. During this meeting, 2 speakers, who had also attended COP15 in Copenhagen, held speeches about their experiences with informative and stimulating issues in Copenhagen. Does the climate issue benefit from a global approach? How did the negotiations proceed behind the scenes? Are there any positive results worth mentioning as opposed to the critical notes. [Dutch] Verslag van een bijeenkomst van NeVER (Nederlandse Vereniging voor Energierecht) op 8 februari 2010 bij de NMa in Den Haag. Tijdens de bijeenkomst hebben 2 sprekers, die aanwezig waren bij de COP15 in Kopenhagen, voordrachten gehouden over hun ervaringen in Kopenhagen met wetenswaardige en prikkelende kwesties. Is het klimaatprobleem gebaat bij een mondiale aanpak? Hoe verliepen de onderhandelingen achter de schermen? Zijn naast de kritiek ook positieve resultaten te benoemen?.

  11. COP-compost: a software to study the degradation of organic pollutants in composts.

    Science.gov (United States)

    Zhang, Y; Lashermes, G; Houot, S; Zhu, Y-G; Barriuso, E; Garnier, P

    2014-02-01

    Composting has been demonstrated to be effective in degrading organic pollutants (OP) whose behaviour depends on the composting conditions, the microbial populations activated and interactions with organic matters. The fate of OP during composting involves complex mechanisms and models can be helpful tools for educational and scientific purposes, as well as for industrialists who want to optimise the composting process for OP elimination. A COP-Compost model, which couples an organic carbon (OC) module and an organic pollutant (OP) module and which simulates the changes of organic matter, organic pollutants and the microbial activities during the composting process, has been proposed and calibrated for a first set of OP in a previous study. The objectives of the present work were (1) to introduce the COP-Compost model from its convenient interface to a potential panel of users, (2) to show the variety of OP that could be simulated, including the possibility of choosing between degradation through co-metabolism or specific metabolism and (3) to show the effect of the initial characteristics of organic matter quality and its microbial biomass on the simulated results of the OP dynamic. In the model, we assumed that the pollutants can be adsorbed on organic matter according to the biochemical quality of the OC and that the microorganisms can degrade the pollutants at the same time as they degrade OC (by co-metabolism). A composting experiment describing two different (14)C-labelled organic pollutants, simazine and pyrene, were chosen from the literature because the four OP fractions simulated in the model were measured during the study (the mineralised, soluble, sorbed and non-extractable fractions). Except for the mineralised fraction of simazine, a good agreement was achieved between the simulated and experimental results describing the evolution of the different organic fractions. For simazine, a specific biomass had to be added. To assess the relative importance

  12. The responsibilities of the 'globalized capital' in the 'programmed failure' of the COP 21. After the COP 21: to stay mobilised

    International Nuclear Information System (INIS)

    Sindic, Paul; Verger, Daniel

    2016-03-01

    A first article proposes a critical assessment of the COP 21. He discusses the position and situation of the USA (notably the fact that the Congress may not ratify propositions made by President Obama on the reduction of CO 2 emissions), of China (the first CO 2 emitter and who still aims at becoming the first world power), and of the European Union (good results in terms of CO 2 reduction, but not so good when taking carbonated renewable energies like wood and biomass into account; definition of general objectives which are not distributed among countries like in the Kyoto protocol), and more general aspects (lack of sanction, no control of demographic growth, problems of poverty and refugees with negative social and societal impacts). The author then outlines, discusses and explains the discrepancies between recommendations made by the IPCC and decisions taken by UNFCCC members (United Nations Framework Convention on Climate Change). He concludes by questions related to the financing of the struggle against climate change, and to ideological difficulties to directly take on the globalized capital. The last article outlines that the mixed review of the COP 21, and briefly discusses the perspectives of the COP 22 in Morocco

  13. Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7)

    International Nuclear Information System (INIS)

    Dessau, Moshe; Chamovitz, Daniel A.; Hirsch, Joel A.

    2006-01-01

    A core fragment of Arabidopsis thaliana COP9 signalosome (CSN) subunit 7 was expressed in Escherichia coli. The protein was purified to homogeneity and crystallized. A core fragment of Arabidopsis thaliana COP9 signalosome (CSN) subunit 7 was expressed in Escherichia coli. The protein was purified to homogeneity and screened for crystallization. Crystallization conditions were refined using the sitting-drop vapour-diffusion method. Crystals were obtained using polyethylene glycol 8000 as a precipitant and have a thick rod-like morphology. Their crystallographic symmetry is orthorhombic, space group C222 1 , with unit-cell parameters a = 57.2, b = 86.2, c = 72.6 Å and a diffraction limit of 2.06 Å

  14. The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.

    Directory of Open Access Journals (Sweden)

    Yi-Chun Huang

    2014-11-01

    Full Text Available During development, neural competence is conferred and maintained by integrating spatial and temporal regulations. The Drosophila sensory bristles that detect mechanical and chemical stimulations are arranged in stereotypical positions. The anterior wing margin (AWM is arrayed with neuron-innervated sensory bristles, while posterior wing margin (PWM bristles are non-innervated. We found that the COP9 signalosome (CSN suppresses the neural competence of non-innervated bristles at the PWM. In CSN mutants, PWM bristles are transformed into neuron-innervated, which is attributed to sustained expression of the neural-determining factor Senseless (Sens. The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br that encodes the BR-Z1 transcription factor to activate sens expression. Strikingly, CSN suppression of BR-Z1 is initiated at the prepupa-to-pupa transition, leading to Sens downregulation, and termination of the neural competence of PWM bristles. The role of ecdysone signaling to repress br after the prepupa-to-pupa transition is distinct from its conventional role in activation, and requires CSN deneddylating activity and multiple cullins, the major substrates of deneddylation. Several CSN subunits physically associate with ecdysone receptors to represses br at the transcriptional level. We propose a model in which nuclear hormone receptors cooperate with the deneddylation machinery to temporally shutdown downstream target gene expression, conferring a spatial restriction on neural competence at the PWM.

  15. Nucleaire et Energies Nr 67 - December 2015. COP21: diplomatic success, a first step

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Salanave, Jean-Luc; Seyve, Claude; Simonnet, Jacques; Justin, Francois; Salanave, Jean-Luc; Darricau, Aime; Raisonnier, Daniele; Deleigne, Francoise; Lepine, Gerard; Witkowski, Didier; Knoche, Philippe

    2015-12-01

    After a first article which comments the results of the Paris Climate Conference (COP21), two articles address recent evolutions in the energy sector: an overview of recent evolutions (perspective for oil reserves, relationship between Gazprom and the EU, news about wind and solar energy in Europe, India, and in France with the most powerful European photovoltaic installation near Bordeaux, electricity prices, reduction of taxes on solar and wind energy foreseen for 2017), and a comparison between renewable energies and the EPR in terms of investment profitability. Three articles concern nuclear activities: recent events about reactors (IAEA forecast, situation and debates in France, Belgium, UK, Sweden, Romania, Slovenia, Russia, Ukraine, Iran, Emirates, Egypt, China, South Korea, Japan, and USA, cooperation between Argentina and China), about the back-end of the fuel cycle and decommissioning activities (activities and situation of different French facilities, activities and contracts in Japan, UK, USA, Taiwan, China, Finland, India and Spain), and the content of the IAEA report on the Fukushima accident. Articles comment issues concerning the relationship between nuclear and society: a comment about the use of the term 'green' and on what is green in nuclear, the recent evolutions negotiations on the issue of the Iranian nuclear industry with respect to non-proliferation, and a comment of the perception of climate change by French people as expressed by different surveys. A last article outlines that Areva will remain a world leader on the long term

  16. The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens.

    Science.gov (United States)

    Hind, Sarah R; Pulliam, Sarah E; Veronese, Paola; Shantharaj, Deepak; Nazir, Azka; Jacobs, Nekaiya S; Stratmann, Johannes W

    2011-02-01

    The COP9 signalosome (CSN) is a multi-protein complex that regulates the activities of cullin-RING E3 ubiquitin ligases (CRLs). CRLs ubiquitinate proteins in order to target them for proteasomal degradation. The CSN is required for proper plant development. Here we show that the CSN also has a profound effect on plant defense responses. Silencing of genes for CSN subunits in tomato plants resulted in a mild morphological phenotype and reduced expression of wound-responsive genes in response to mechanical wounding, attack by Manduca sexta larvae, and Prosystemin over-expression. In contrast, expression of pathogenesis-related genes was increased in a stimulus-independent manner in these plants. The reduced wound response in CSN-silenced plants corresponded with reduced synthesis of jasmonic acid (JA), but levels of salicylic acid (SA) were unaltered. As a consequence, these plants exhibited reduced resistance against herbivorous M. sexta larvae and the necrotrophic fungal pathogen Botrytis cinerea. In contrast, susceptibility to tobacco mosaic virus (TMV) was not altered in CSN-silenced plants. These data demonstrate that the CSN orchestrates not only plant development but also JA-dependent plant defense responses. © 2011 The Authors. The Plant Journal © 2011 Blackwell Publishing Ltd.

  17. Climate and enterprises: from mobilisation to action. Seven proposals to prepare the after-COP21

    International Nuclear Information System (INIS)

    Ayme, Arnaud; Derumaux, Quentin; Authier, Marc-Antoine; Monterno, Alexia de; Piolot, Lucie

    2015-11-01

    Based on meetings with 30 representatives of enterprises and institutions, this report first outlines that the COP21 takes place within a context characterised by a momentum which is to be exploited as awareness grows quickly, as data published by the IPCC is a consensus. It outlines that national climate contributions represent a positive methodological evolution and discusses the importance of bilateral agreements (example and the China-USA agreement), and gives an overview of remaining obstacles (financing the struggle against climate change, level playing field for European enterprises, how to support the losers of energy transition). The mobilisation of enterprises is then described as a new lever in the struggle against climate change: strong signals are sent by the financial sector; enterprises are facing many challenges. This mobilisation is presented as an unavoidable stake in negotiations. A necessary action of public authorities is outlined. Some proposals are stated regarding public financing of the struggle against climate change, the focussing of regulatory constraints on this struggle, public commissioning as a lever for a successful environmental transition, and the role of public authorities as a mediator between civil society and enterprises

  18. KINGS Model: Achieving Sustainable Change in Nuclear Engineering Education for the Post-COP21 Era

    International Nuclear Information System (INIS)

    Oh, S.-K.

    2016-01-01

    Full text: In spite of the world nuclear community’s systematic and multilateral efforts during the COP21, most of the conference participants were reluctant to acknowledge the value of nuclear as a low-carbon energy source. In fact, the on-going aftermath of the Fukushima nuclear disaster has been overwhelming despite the evidence that there was neither any critical technical flaw nor fatal radiation casualties. This shows that advanced nuclear knowledge failed to resonate with public perception on nuclear energy. In this respect, it is now time to focus on achieving sustainable change in nuclear engineering education for the future. The KEPCO International Nuclear Graduate School (KINGS) was established to nurture leadership-level nuclear power professionals in the global standard. It affiliates with Korean nuclear industry to achieve three major goals that are also a universal prerequisite for higher education of engineering in the 21st century as follows: “a balance between education and training,” “harmony between engineering and managerial skills,” and “the application of systems engineering to nuclear power projects.” KINGS curriculum requires transdisciplinary coordination among engineering disciplines, engineering specialties, and socioeconomic methods. (author

  19. Point Climat no. 33 'International Climate Negotiations - COP 19: do not underestimate the MRV breakthrough'

    International Nuclear Information System (INIS)

    Dupont, Marion; Morel, Romain; Bellassen, Valentin; Deheza, Mariana

    2013-01-01

    Among the publications of CDC Climat Research, 'Climate Briefs' presents, in a few pages, hot topics in climate change policy. This issue addresses the following points: For those who expect 'binding' emission reductions targets in the future international climate agreement to be signed in Paris in 2015, the Warsaw Conference (November 11 to 23, 2013) yielded as much progress as it could. That means little beyond a timetable. However, for those who consider the UNFCCC as the depository of common tools on the monitoring, reporting and verification (MRV) of emissions, actions and financing, Warsaw represents a major breakthrough. For the first time, developing countries - at least those wishing to access climate finance for forests - will abide by MRV procedures similar to those governing the greenhouse gas inventories of industrialized countries. Forestry may be seen as a first sectoral NAMA, and it would be difficult to ignore the Warsaw decisions for the future definition of MRV procedures of NAMAs. In spite of the establishment of the Warsaw International Mechanism for Loss and Damage, low outputs on other issues show that achieving an agreement at COP 21 will require significant political progress during the next 15 months

  20. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development.

    Science.gov (United States)

    Wang, Xiping; Feng, Suhua; Nakayama, Naomi; Crosby, W L; Irish, Vivian; Deng, Xing Wang; Wei, Ning

    2003-05-01

    The COP9 signalosome (CSN) is involved in multiple developmental processes. It interacts with SCF ubiquitin ligases and deconjugates Nedd8/Rub1 from cullins (deneddylation). CSN is highly expressed in Arabidopsis floral tissues. To investigate the role of CSN in flower development, we examined the expression pattern of CSN in developing flowers. We report here that two csn1 partially deficient Arabidopsis strains exhibit aberrant development of floral organs, decline of APETALA3 (AP3) expression, and low fertility in addition to defects in shoot and inflorescence meristems. We show that UNUSUAL FLORAL ORGANS (UFO) forms a SCF(UFO) complex, which is associated with CSN in vivo. Genetic interaction analysis indicates that CSN is necessary for the gain-of-function activity of the F-box protein UFO in AP3 activation and in floral organ transformation. Compared with the previously reported csn5 antisense and csn1 null mutants, partial deficiency of CSN1 causes a reduction in the level of CUL1 in the mutant flowers without an obvious defect in CUL1 deneddylation. We conclude that CSN is an essential regulator of Arabidopsis flower development and suggest that CSN regulates Arabidopsis flower development in part by modulating SCF(UFO)-mediated AP3 activation.

  1. Law, Urban Violence and Order: Cop Shows as a Brazilian TV Genre

    Directory of Open Access Journals (Sweden)

    Luiza Lusvarghi

    2014-04-01

    Full Text Available A new type of Brazilian drama series has taken place on local  TV -  the cop shows. Although they are not popular as the telenovela (soap operas, definitively they came to stay.  International channels like Fox and HBO are benefited by Tax Benefits Rule which provides financial conditions for the production of those home market, and are now competing with the two greatest media Brazilian  groups – Record and Globo.  The worldwide success of “Cidade de Deus” (City of God, 2002, Fernando Meirelles, released abroad like a gangster movie, and “Tropa de Elite” (Elite Squad, 2005, Jose Padilha, Berlin Golden Bear Award 2008, which sequel “Elit Squad: The Enemy Within” (2010 became the biggest box office record of Brazilian Cinema, could be partially contributed to motivate that new kind of production, which mix up social exclusion, urban violence with the very known old formulas of American serials, as the franchise “Law and Order” and its various spin-offs.

  2. Tamoxifen induces regression of estradiol-induced mammary cancer in ACI.COP-Ept2 rat model

    OpenAIRE

    Ruhlen, Rachel L.; Willbrand, Dana M.; Besch-Williford, Cynthia L.; Ma, Lixin; Shull, James D.; Sauter, Edward R.

    2008-01-01

    The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5–7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonan...

  3. A Location Privacy Aware Friend Locator

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2009-01-01

    to trade their location privacy for quality of service, limiting the attractiveness of the services. The challenge is to develop a communication-efficient solution such that (i) it detects proximity between a user and the user’s friends, (ii) any other party is not allowed to infer the location of the user...

  4. Simulating the dynamics of polycyclic aromatic hydrocarbon (PAH) in contaminated soil through composting by COP-Compost model.

    Science.gov (United States)

    Zhang, Yuan; Guan, Yidong; Shi, Qi

    2015-02-01

    Organic pollutants (OPs) are potentially present in composts, and the assessment of their content and bioaccessibility in these composts is of paramount importance to minimize the risk of soil contamination and improve soil fertility. In this work, integration of the dynamics of organic carbon (OC) and OPs in an overall experimental framework is first proposed and adopted to validate the applicability of the COP-Compost model and to calibrate the model parameters on the basis of what has been achieved with the COP-Compost model. The COP-Compost model was evaluated via composting experiments containing 16 US Environmental Protection Agency (USEPA) polycyclic aromatic hydrocarbons (PAHs) and the sorption coefficient (Kd) values of two types of OP: fluorenthene (FLT) and pyrene (PHE). In our study, these compounds are used to characterize the sequential extraction and are quantified as soluble, sorbed, and non-extractable fractions. The model was calibrated, and coupling the OC and OP modules improved the simulation of the OP behavior and bioaccessibility during composting. The results show good agreement between the simulated and experimental results describing the evolution of different organic pollutants using the OP module, as well as the coupling module. However, no clear relationship is found between the Kd and the property of organic fractions. Further estimation of parameters is still necessary to modify the insufficiency of this present research.

  5. Conferencia de Cambio Climático: resultados de la COP 20 en Perú

    Directory of Open Access Journals (Sweden)

    Wilfredo Bulege Gutiérrez

    2014-12-01

    Full Text Available El sentir ciudadano en defensa de la calidad de vida es ya de preocupación e indignación global. Siguiendo a Mónica Araya (1, podemos decir que a menor contaminación, más espacios verdes y mayor energía limpia, y a medida que estas aspiraciones entran en el imaginario ciudadano, van creándose condiciones favorables para el reclamo masivo y uso global de energía renovable. La reconocida economista costarricense y negociadora en cambio climático por su país, destaca que la petición en línea planteada por los ciudadanos este año ha exigido a los gobiernos optar por la energía limpia al cien por ciento, reclamo apoyado por 2,2 millones de personas en el mundo, y que la Marcha Popular por el Clima del 21 de septiembre de 2014 ha marcado un hito. Más de 400 000 ciudadanos caminaron pacíficamente por las calles de Manhattan apoyados por 3 000 actos que iban desde Bogotá hasta Sydney. Hubo marchas en 166 países con lúcidas expresiones ciudadanas a favor de una economía que no dañe la salud de las personas, que crezca a través del uso de energía renovable y sea justa (1. Según una encuesta del Banco Interamericano de Desarrollo (BID, al ciudadano latinoamericano le preocupa el cambio climático (2. Sabe que es un problema real y que puede llegar a impactar su entorno. Ya el 2 de noviembre oímos a la comunidad científica internacional a través del Panel Intergubernamental de Cambio Climático (IPCC, al publicar su Quinto Informe –el más reciente-, en el que la realidad y urgencia de atender el fenómeno del cambio climático es impostergable (1. Establecida en la Cumbre de Río en 1992, la Convención Marco de las Naciones Unidas sobre el Cambio Climático (CMNUCC entra en vigor en 1994 con el objetivo de reducir las concentraciones de gases de efecto invernadero (GEI en la atmósfera, y en 1995 impulsa la Conferencia de las Partes (COP, por sus siglas en inglés como órgano supremo de toma de decisiones. Los 195 pa

  6. Onderzoek Location Based Marketing: Mobile = location = effect

    NARCIS (Netherlands)

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based

  7. [Offsets under the Kyoto Protocol : a perspective on COP 4 negotiations

    International Nuclear Information System (INIS)

    Kelly, E.

    1998-01-01

    The achievements of the Kyoto Protocol were highlighted. These achievements include recognition of the need for Annex 1 countries (developed countries) to define concrete emissions reduction targets to be accomplished by 2012; recognition of specific needs of developing countries; need for measures to anticipate, prevent or minimize the causes of climate change; recognition of the need that climate change policies and measures be cost effective; taking into account that economic development is essential for adopting measures to address climate change; recognition of the principle that corporations should promote a supportive and open international economic system leading to sustainable growth; and recognition that measures taken to combat climate change should not lead to unjustifiable discrimination in international trade. If the targets set at Kyoto are achieved, there will be an effective reduction in greenhouse gases of 5.2 per cent in relation to 1990 levels. The meeting in Buenos Aires should focus on strengthening the guidelines for actions agreed upon in Kyoto. Other major issues on the Buenos Aires Conference of Parties (COP 4) agenda should be to discuss ways and means to helping developing countries to deal with climate change issues within their own territories, agreement about definitive status of the Global Environmental Fund, arriving at a more precise definition of the Clean Development Mechanism, and first and foremost the development of credible national systems (i.e. Annex 1 countries) for the estimation of anthropogenic emission sources and removal by sinks of all greenhouse gases not controlled by the Montreal Protocol on the Ozone Layer, and shaping an adequate non-compliance system

  8. The right view from the wrong location: depth perception in stereoscopic multi-user virtual environments.

    Science.gov (United States)

    Pollock, Brice; Burton, Melissa; Kelly, Jonathan W; Gilbert, Stephen; Winer, Eliot

    2012-04-01

    Stereoscopic depth cues improve depth perception and increase immersion within virtual environments (VEs). However, improper display of these cues can distort perceived distances and directions. Consider a multi-user VE, where all users view identical stereoscopic images regardless of physical location. In this scenario, cues are typically customized for one "leader" equipped with a head-tracking device. This user stands at the center of projection (CoP) and all other users ("followers") view the scene from other locations and receive improper depth cues. This paper examines perceived depth distortion when viewing stereoscopic VEs from follower perspectives and the impact of these distortions on collaborative spatial judgments. Pairs of participants made collaborative depth judgments of virtual shapes viewed from the CoP or after displacement forward or backward. Forward and backward displacement caused perceived depth compression and expansion, respectively, with greater compression than expansion. Furthermore, distortion was less than predicted by a ray-intersection model of stereo geometry. Collaboration times were significantly longer when participants stood at different locations compared to the same location, and increased with greater perceived depth discrepancy between the two viewing locations. These findings advance our understanding of spatial distortions in multi-user VEs, and suggest a strategy for reducing distortion.

  9. Determinantes estructurales y su relación con el índice de COP en países de desarrollo alto, mediano y bajo

    Directory of Open Access Journals (Sweden)

    Luis Carlos García Rincón

    2015-01-01

    Full Text Available Objetivo: describir y analizar los determinantes estructurales y su relación con el índice de COP en países de desarrollo alto, mediano y bajo durante las últimas tres décadas. Materiales y métodos: estudio descriptivo realizado a partir de una revisión de la literatura internacional y nacional en bases de datos y páginas web. Resultados: se encontró un país con índice de COP elevado; un país con índice de COP moderado; 10 países con índice de COP bajo; y 10 países con índice de COP muy bajo. Los países de desarrollo alto y los países de desarrollo bajo se comportan de manera similar en tanto reportan índices de COP inferiores al promedio mundial sugerido por la OMS (2.4. Discusión y conclusiones: se concluye que los valores de COP están asociados fuertemente a factores macroeconómicos, como las políticas y servicios de cuidado de la salud disponibles para la población, más que a la clasificación de desarrollo del Banco Mundial. Los determinantes sociales están directamente relacionados con las políticas estructurales que afectan el bienestar social, la salud y la calidad de vida de la población.

  10. Location | FNLCR Staging

    Science.gov (United States)

    The Frederick National Laboratory for Cancer Research campus is located 50 miles northwest of Washington, D.C., and 50 miles west of Baltimore, Maryland, in Frederick, Maryland. Satellite locations include leased and government facilities extending s

  11. Appraising manufacturing location

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.

    2002-01-01

    International location of manufacturing activities is an issue for managers of manufacturing companies as well as public policy makers. For managers, the issue is relevant because international locations offer opportunities for lowering costs due to productivity improvements. For governments the

  12. Law Enforcement Locations

    Data.gov (United States)

    Kansas Data Access and Support Center — Law Enforcement Locations in Kansas Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law enforcement agencies "are...

  13. The Effects of Balance Training on Stability and Proprioception Scores of the Ankle in College Students

    Directory of Open Access Journals (Sweden)

    Andrew L. Shim

    2015-10-01

    Full Text Available Objective: The purpose of this study was to determine if stability and proprioception scores improved on college-aged students using a slack line device. Methods: One group of 20 participants aged 18-23 from a Midwestern university performed a pre-test/post-test on a computerized posturography plate to determine Center of Pressure (CoP and Limit of Stability (LoS scores.  Participants performed three 20-30 minute sessions per week of balance and proprioceptive training using a Balance Bow for a period of four weeks. Data were analyzed (SPSS 21.0 using a dependent t-test to determine if any changes occurred between pre- and post-test scores after four weeks.  Results: The analyses found no significance difference in Center of Pressure (CoP, normal stability eyes open (NSEO, normal stability eyes closed (NSEC, perturbed stability eyes open (PSEO, perturbed stability eyes closed (PSEC, or LoS forward (F, backward (B, or right (R scores in college-aged participants. A significant difference was found in LoS left (L and a notable trend towards significance was found in LoS R results. Conclusion: With the exception of LoS L stability scores, it was concluded that 12 sessions of 20-30 minutes, utilizing a slack line device, over a four week training period did not significantly improve stability and proprioceptive scores of the ankle in college-aged participants. Keywords: Proprioception, Limit of Stability (LoS, Center of Pressure (CoP, slack line device

  14. Making the COP21 work. From international to national scope: the impact of climate negotiations on public action

    International Nuclear Information System (INIS)

    Lefebvre, Coline; Delory, Linda; Guibert, Geraud

    2015-12-01

    How to appreciate, when the time comes, the results of the COP21? What are the elements that can make it truly useful? La Fabrique Ecologique and CliMates, on the basis of an exclusive and meticulous international survey underline them: the important part of an efficient climate action does not always rely on what we believe. The most influential aspect will be the commitment to future objectives and steps, strong principles of transparency and the extent of real domestic commitments for a new development strategy. A few weeks ahead of the COP21, what can we really expect? It is very likely that, as for the previous COPs, there will be an agreement, but we still need to see if it will be satisfactory. Facing the extent of the climate challenge and the complex negotiation, it remains urgent to have a clear and precise vision of what this international conference could bring. To measure it, La Fabrique Ecologique and CliMates have led an exclusive survey on the impact in recent years of the annual meetings of the COPs on climate policies of 16 States and 5 local authorities. This survey shows several paradoxes: the legally binding character proved to be not so binding after all; the sense of failure sometimes hid real successes; the negotiation itself having a strong impact on its results. It enables to identify the most important factors which have already led to action: the creation of shared knowledge and transparency standards, the obligation of setting an example for countries willing to be included in the negotiation, the search of economic and social co-benefits of climate action with a view to a new development strategy, the emergence of a global climate civil society. Far too often, the COP21 is presented as a deadline, a final date to solve the most complex and global challenge Man has ever faced: climate deregulation. Presented as the umpteenth 'last-ditch conference', the Paris negotiation might generate many 'climate resigned people

  15. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia.

    Science.gov (United States)

    Charles, Patrick G P; Wolfe, Rory; Whitby, Michael; Fine, Michael J; Fuller, Andrew J; Stirling, Robert; Wright, Alistair A; Ramirez, Julio A; Christiansen, Keryn J; Waterer, Grant W; Pierce, Robert J; Armstrong, John G; Korman, Tony M; Holmes, Peter; Obrosky, D Scott; Peyrani, Paula; Johnson, Barbara; Hooy, Michelle; Grayson, M Lindsay

    2008-08-01

    Existing severity assessment tools, such as the pneumonia severity index (PSI) and CURB-65 (tool based on confusion, urea level, respiratory rate, blood pressure, and age >or=65 years), predict 30-day mortality in community-acquired pneumonia (CAP) and have limited ability to predict which patients will require intensive respiratory or vasopressor support (IRVS). The Australian CAP Study (ACAPS) was a prospective study of 882 episodes in which each patient had a detailed assessment of severity features, etiology, and treatment outcomes. Multivariate logistic regression was performed to identify features at initial assessment that were associated with receipt of IRVS. These results were converted into a simple points-based severity tool that was validated in 5 external databases, totaling 7464 patients. In ACAPS, 10.3% of patients received IRVS, and the 30-day mortality rate was 5.7%. The features statistically significantly associated with receipt of IRVS were low systolic blood pressure (2 points), multilobar chest radiography involvement (1 point), low albumin level (1 point), high respiratory rate (1 point), tachycardia (1 point), confusion (1 point), poor oxygenation (2 points), and low arterial pH (2 points): SMART-COP. A SMART-COP score of >or=3 points identified 92% of patients who received IRVS, including 84% of patients who did not need immediate admission to the intensive care unit. Accuracy was also high in the 5 validation databases. Sensitivities of PSI and CURB-65 for identifying the need for IRVS were 74% and 39%, respectively. SMART-COP is a simple, practical clinical tool for accurately predicting the need for IRVS that is likely to assist clinicians in determining CAP severity.

  16. The influence of light hypothenar contact during a reaching movement on the centre of pressure (COP forward displacement.

    Directory of Open Access Journals (Sweden)

    Darja Rugelj

    Full Text Available The purpose of this study was to evaluate the effect of additional light hand contact (F<1 N in the region of the hypothenar eminence on forward movement of the center of pressure (COP and dominant hand. Subjects sled their hypothenar eminence on a vertically-oriented pressure sensitive board while reaching forward beyond their arm length. In the two separate experiments forty nine healthy, college-aged volunteers participated in the study. Thirty subjects (mean age of 22.2±2.4 years, 6 male and 24 female participated in the experiment on level ground and nineteen subjects (22±2.6 years, 5 male and 14 female in the experiment on an elevated surface. The forward displacement of the COP was significantly larger (p = 0.002 when subjects were allowed to slide with the hand as compared to no contact when the activity occurred on level ground (84±10 mm and 79±11 mm, respectively, and on a one meter elevated surface (71±17 mm and 65±21 mm, respectively. The maximal forward reach of the dominant hand was significantly greater when subjects were allowed to slide with the hypothenar eminence as compared to the no contact condition on the level ground (336±35 mm and 344±38 mm, respectively, p<0.02, and on the one meter elevated surface (298±58 mm and 307±58 mm, respectively, p<0.01. This data indicate that subjects were able to use additional haptic information from the hypothenar region to bring their COP and dominant hand further forward while standing on level ground as well as on a one m elevated surface.

  17. Development of Internet algorithms and some calculations of power plant COP

    Science.gov (United States)

    Ustjuzhanin, E. E.; Ochkov, V. F.; Znamensky, V. E.

    2017-11-01

    sharing: a) SW that is used to design power plants, for an example, Code - GTP_1(Z,R,Y) and b) client functions those are aimed to determine R properties of the working fluid at fixed points of the thermodynamic cycle. The program let us calculate energy criteria, Z, including the internal coefficient of performance (COP) for a power plant. We have discussed OI resources, among them OI resource that includes Code - GTP_1(Z,R,Y) and connected with a complex power plant included: i) several gas turbines, i) several compressors etc.

  18. Smartphones as locative media

    CERN Document Server

    Frith, Jordan

    2015-01-01

    Smartphone adoption has surpassed 50% of the population in more than 15 countries, and there are now more than one million mobile applications people can download to their phones. Many of these applications take advantage of smartphones as locative media, which is what allows smartphones to be located in physical space. Applications that take advantage of people's location are called location-based services, and they are the focus of this book. Smartphones as locative media raise important questions about how we understand the complicated relationship between the Internet and physical space

  19. International climate policy leadership after COP23: the EU must resume its leading role, but cannot do so alone

    OpenAIRE

    Dröge, Susanne; Rattani, Vijeta

    2018-01-01

    The net outcome of the Bonn climate talks (23rd Conference of the Parties, COP23) in November was lukewarm at best. Many technical issues were brought forward and the political risks caused by the US announcement to pull out of the Paris Agreement were kept at bay. Yet, leadership to fill the void left by the US was lacking. Germany, who was co-hosting with the Fiji Islands, could not table ambitious solutions as in November 2017 it only had a caretaker government in place. The Fiji Presidenc...

  20. Cable Stability

    Energy Technology Data Exchange (ETDEWEB)

    Bottura, L [European Organization for Nuclear Research, Geneva (Switzerland)

    2014-07-01

    Superconductor stability is at the core of the design of any successful cable and magnet application. This chapter reviews the initial understanding of the stability mechanism, and reviews matters of importance for stability such as the nature and magnitude of the perturbation spectrum and the cooling mechanisms. Various stability strategies are studied, providing criteria that depend on the desired design and operating conditions.

  1. Situación de riesgo por la presencia de COP: evidencias del problema y escenarios de solución

    Directory of Open Access Journals (Sweden)

    Berenice Ochoa Nogales

    2012-01-01

    Full Text Available En este artículo se presentan resultados preliminares del proyecto de investigación titulado “Desarrollo de una metodología que permita llevar a cabo el inventario, caracterización y verificación de sitios potencialmente contaminados con Compuestos Orgánicos Persistentes (COP en las principales zonas agrícolas del estado de Sonora”. Primero, se destacan algunos planteamientos que emergen de la sociedad del riesgo respecto a la problemática ambiental en general y a la de los COP en particular. Después, se realiza una aproximación a la problemática por COP que dio pie al Convenio de Estocolmo, las evidencias de tal problema en México, en Sonora y las obligaciones que se asumen al suscribirse a tal convenio. A nivel nacional, el énfasis se coloca en el análisis de la normativa ambiental vinculada a tóxicos; y, a nivel estatal, en mostrar evidencias de la presencia de COP y su impacto en el ambiente y la salud humana. Para terminar, se reflexiona en torno a los retos y áreas de oportunidad que para México significa el atender la problemática por COP de seguirse los lineamientos internacionales, la normativa oficial y lo que sugiere el análisis desde la perspectiva del riesgo.

  2. Lost in Location

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    traversed. While becoming destination aware, the individual loses her location awareness. The article proposes that the reason people get lost when using sat-nav is due to a wrong location-performative paradigm. As an alternative, the article introduces and analyzes two performance-related examples...... that illustrate an alternative location-performative paradigm: Meredith Warner's Lost/Found knitting series and Etter and Schecht's Melodious Walkabout. In both examples, the artist's hand becomes the intermediary between alien and location. Thus, by exploring how wayfinding can be a poetically situated...... performance, the article examines how the growing locative media industry can learn from the location-aware performative strategies employed by artists who create situated and urban performances for the curious participant. The academic frames employed in the analysis draw on psychogeography, site...

  3. Internet Geo-Location

    Science.gov (United States)

    2017-12-01

    INTERNET GEO-LOCATION DUKE UNIVERSITY DECEMBER 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR...REPORT TYPE FINAL TECHNICAL REPORT 3. DATES COVERED (From - To) MAY 2014 – MAY 2017 4. TITLE AND SUBTITLE INTERNET GEO-LOCATION 5a. CONTRACT...of SpeedTest servers that are used by end users to measure the speed of their Internet connection. The servers log the IP address and the location

  4. Smart Location Database - Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  5. Smart Location Database - Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  6. Spatio-temporal soil moisture variability in Southwest Germany observed with a new monitoring network within the COPS domain

    Energy Technology Data Exchange (ETDEWEB)

    Krauss, Liane; Kottmeier, Christoph [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inst. for Meteorology and Climate Research; Hauck, Christian [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inst. for Meteorology and Climate Research; Fribourg Univ. (Switzerland). Dept. of Geosciences

    2010-12-15

    Within the 'Convective and Orographically-induced Precipitation Study' (COPS) 2007 in Southwest Germany and Northeast France a soil moisture monitoring network was installed. The aim of the network is to identify the interaction between the temporal and spatial variability of the soil moisture field and its influence on the energy balance and the moisture availability in the planetary boundary layer. The network is comprised of a large number of newly developed low-cost soil moisture sensors based on the frequency-domain reflectometry method (FDR). In total 47 soil moisture stations within the COPS domain were each equipped with two to four sensors simultaneously measuring vertical profiles of soil moisture and soil temperature down to 50 cm depth. This contribution describes the soil moisture network, its installation procedure and the calibration of the sensor output signal. Furthermore we discuss the soil texture distribution within the study area and present first analyses of the spatio-temporal soil moisture variability during a 13 month period from June 2007 till June 2008 based on regional differences and site specific properties (altitude and soil texture). Results show that the altitude plays a key role for the overall soil moisture pattern relative to the area mean due to the direct linkage to precipitation patterns. Soil texture controls the vertical soil moisture gradient relative to the near surface soil moisture, as their properties control water storage and drainage characteristics. Both factors significantly influence regional soil moisture patterns in Southwest Germany. (orig.)

  7. COP21: success at 'the end of the beginning'. Climate Brief No.38

    International Nuclear Information System (INIS)

    Bultheel, Clement; Morel, Romain; Hainaut, Hadrien; Deheza, Mariana; Shishlov, Igor; Depoues, Vivian; Leguet, Benoit

    2015-01-01

    The Paris Agreement provides a clear signal and a solid framework for climate action. Balanced and ambitious in its objectives - including full decarbonization of the global economy before the end of the century - it has all the conditions to encourage everyone to do more. In establishing a new international climate change regime, the Agreement focuses on the essentials: guiding countries towards low-carbon and climate resilient economies. The main challenge resides not in the direct implementation of the decisions taken in Paris, but rather in the alignment of countries' national strategies with a decarbonization trajectory. COP21 marks the advent of a new regime of international cooperation rather than a 'utopian' and politically unpalatable system to punish or coerce States to take action. It confirms the desire to engage both State and non-State actors on climate action. In this respect, it is a real victory of multilateralism. Indeed, COP21 marks the 'end of the beginning' of a long negotiations process to shift to a permanent regime, completed by regular appointments to boost ambition. This victory, however, will become historical only if this cooperation leads to enhanced action and concrete results. And this is where the hard work begins

  8. Green facility location

    NARCIS (Netherlands)

    Velázquez Martínez, J.C.; Fransoo, J.C.; Bouchery, Y.; Corbett, C.J.; Fransoo, J.C.; Tan, T.

    2017-01-01

    Transportation is one of the main contributing factors of global carbon emissions, and thus, when dealing with facility location models in a distribution context, transportation emissions may be substantially higher than the emissions due to production or storage. Because facility location models

  9. Industrial location and competitiveness

    NARCIS (Netherlands)

    S. Brakman (Steven); J.H. Garretsen (Harry); J.G.M. van Marrewijk (Charles)

    2006-01-01

    textabstractThe interaction between the extent of location advantages and the intensity of firm competition relative to the size of the market jointly determines the location of industrial activity. Technology, factor endowments, geography, and scale economies are influential for determining

  10. The status and prospects of the debate upon the nuclear power in the climate change talks: focused on the result of COP7

    International Nuclear Information System (INIS)

    Lee, C. Y.; Kim, S. S.

    2002-01-01

    Possible climate change caused by global warming becomes one of the most serious challenges that mankind shall tackle in 21 st century. Nuclear power, which doesn't emit any greenhouse gas during the generation of electricity, is a promising solution to mitigate the global warming. The agreement on this matter at COP7, however, resulted in an unfavorable conclusion that may shrink the role of nuclear power in the greenhouse gas abatement. This paper looks into the negotiation process at COP7 especially focused on the nuclear matters and then gives some implications of the agreement

  11. Estructura genética del copépodo Acartia lilljeborgii en la costa del estado de Yucatán, México

    OpenAIRE

    Jorge Tello-Cetina; Lucia Gómez-Victoria; Roberto Zamora-Bustillos; Gerardo Rivera-Muñoz; Sara Solis-Pereira; Herbert Loria-Sunza

    2013-01-01

    Se determinó la estructura genética poblacional y sus implicancias dentro de la cadena trófica del copépodo Acartia lilljeborgii en la costa de Yucatán, mediante el uso de isoenzimas y su posterior determinación por electroforesis. Nueve sistemas se expresaron con un máximo de 30 loci. El polimorfismo y heterocigosis de las poblaciones estudiadas, al ser comparados con otras especies de copépodos, resultaron ser bajos y de los cuatro loci que presentaron variación, solo los loci EST2 y PGM1 s...

  12. Estructura trófica de los copépodos pelágicos en el Océano Pacifico Oriental Tropical

    OpenAIRE

    López Ibarra, Gladis Angélica

    2008-01-01

    Gran parte de la productividad secundaria marina es aportada por los copépodos, estos destacan dentro del zooplancton marino por su diversidad y abundancia, puede llegar a constituir un 80 % de la biomasa zooplanctonica. Probablemente el principal papel ecológico de esta comunidad es la transferencia de energía entre los niveles tróficos primarios y los sucesivos en las redes tróficas. En este estudio se analizó la estructura trófica de la comunidad de copépodos pelágicos en el Océano Pacifi...

  13. Isolation of three B-box zinc finger proteins that interact with STF1 and COP1 defines a HY5/COP1 interaction network involved in light control of development in soybean

    International Nuclear Information System (INIS)

    Shin, Su Young; Kim, Seong Hee; Kim, Hye Jin; Jeon, Su Jeong; Sim, Soon Ae; Ryu, Gyeong Ryul; Yoo, Cheol Min; Cheong, Yong Hwa; Hong, Jong Chan

    2016-01-01

    LONG HYPOCOTYL5 (HY5) and STF1 (Soybean TGACG-motif binding Factor 1) are two related bZIP transcription factors that play a positive role in photomorphogenesis and hormonal signaling. In this study, we compared full length STF1 and truncated STF1 overexpression lines and found that the C-terminal 133 amino acids (194–306) possess all the HY5-like function in Arabidopsis. The STF1-DC1 mutant (1–306), with a 20 amino acid deletion at the carboxy terminus, failed to complement the hy5 mutant phenotype, which suggests an intact C-terminus is required for STF1 function. To understand the role of the C-terminal domain in photomorphogenesis we used a yeast two-hybrid screen to isolate proteins that bind to the STF1 C-terminus. We isolated three soybean cDNAs encoding the zinc-finger proteins GmSTO, GmSTH, and GmSTH2, which interact with STF1. These proteins belong to a family of B-box zinc finger proteins that include Arabidopsis SALT TOLERANCE (STO) and STO HOMOLOG (STH) and STH2, which play a role in light-dependent development and gene expression. The C-terminal 63 amino acids of STF1, containing a leucine zipper and the two N-terminal B-boxes, contains the domain involved in interactions between STF1 and GmSTO. In addition, we identified an interaction between soybean COP1 (GmCOP1) and GmSTO and GmSTH, as well as STF1, which strongly suggests the presence of a similar regulatory circuit for light signaling in soybean as in Arabidopsis. This study shows that photomorphogenic control requires complex molecular interactions among several different classes of transcription factors such as bZIP, B-box factors, and COP1, a ubiquitin ligase. - Highlights: • STF1 interact with GmSTO, GmSTH and GmSTH2. • The bZIP transcription factor STF1 requires an intact C-terminal domain for STF1 function. • STF1 and GmSTO are nuclear proteins.

  14. Assessment of postural stability in overweight and obese middle-aged women

    Directory of Open Access Journals (Sweden)

    Zuzana Kováčiková

    2014-09-01

    Full Text Available Background: Obesity and overweight are defined as abnormal or excessive fat accumulation and are associated with balance disorders. Objective: To assess the postural stability in a natural stance in overweight and obese women based on center of pressure (CoP velocity in the anterior-posterior (AP and medial-lateral (ML directions. Methods: A total of 102 women categorized according to body mass index into normal weight, overweight and obese categories underwent a measurement of quiet standing with their eyes open (EO and with their eyes closed (EC. Postural stability was assessed with a force platform. The mean CoP velocity was evaluated in both directions. Results: In the AP direction under EO conditions, obese women swayed significantly faster than normal weight women (1.01 cm/s and 0.80 cm/s. In the ML direction, a higher CoP velocity was observed in normal weight women than in obese women (0.52 cm/s and 0.41 cm/s. Under EC conditions in the AP direction, obese women swayed significantly faster than normal weight women (1.29 cm/s and 0.97 cm/s. In the ML direction, a higher CoP velocity was observed in normal weight women than in obese women (0.65 cm/s and 0.48 cm/s. Conclusions: Results suggest a negative impact of obesity on postural stability in the AP direction. In the ML direction, obese women were more stable than normal weight women, probably due to enlargement of the support base in a natural stance.

  15. Abstract Collection of 25th Forum: Energy Day in Croatia: A Unique Energy and Climate Policy in Open Energy Market - A Year After COP 21

    International Nuclear Information System (INIS)

    2016-01-01

    Implement an Energy Policy in Light of new EU Guidelines for the year 2030; 2015, EU Energy Policy After 21st Conference of the Parties to the UN Framework Convention on Climate Change (COP21); and this years' Forum subject is: 2016, A Unique Energy and Climate Policy in Open Energy Market - A year After COP21. From the subjects, above, the complexity of energy development is visible and it will further increase in the future. Energy future preoccupies the entire energy and international community. To face different problems, such as: climate change and increasing of energy demand, terrorist and war threats, technological development that doesn't always provide all the answers, poverty and needs of underdeveloped countries, it is necessary to have a stronger international coordination in searching for long-term solutions that can make energy development less uncertain and to reduce the risks that are involved. Technological development is one of the possible answers to energy problems, but is not the only answer. Increasing energy efficiency is a social challenge that surpasses the technology problem. Accepting locations for building new energy plants is also a social challenge. Energy industry is a synergy of different factors: climate preservation, energy market, infrastructure that enables good connection, resource diversification, bigger use of renewable energy sources, energy efficiency. The only energy systems that are secure are the ones with a proper balance. A unique energy and climate policy is the solution to the problems facing energy industry and a proper direction for energy development. Croatia has made its first significant step. Energy and climate preservation are a part of one ministry, which helps creating a unique energy and climate policy. That is a necessary step, but it is not enough for accomplishing a successful energy policy. For a successful energy policy, a synergy of legislation and measures adopted is essential.(author)

  16. Allegheny County Dam Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset shows the point locations of dams in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open data portal...

  17. Smart Location Mapping

    Science.gov (United States)

    The Smart Location Database, Access to Jobs and Workers via Transit, and National Walkability Index tools can help assess indicators related to the built environment, transit accessibility, and walkability.

  18. OAS :: Our Locations

    Science.gov (United States)

    the Human Resources of the OAS, including its organizational structure, each organizational unit's contract and travel control measure reports, the applicable procurement rules and regulations, and the Charter Organizational Charts Organizational List Authorities Our Locations Contact Us Telephone: +1 (202

  19. VT Hospital Site Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This data layer contains point locations of all major community, regional, comprehensive health, and healthcare provider hospitals in the state of...

  20. SGA Project Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — The stream geomorphic assessment is a physical assessment competed by geomorphologists to determine the condition and sensitivity of a stream. The SGA locations...

  1. Waste Recovery Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Locations where City residents are encouraged to drop off and dispose or recycle of unwanted materials. Information provided is subject to change. Please call ahead...

  2. Global Volcano Locations Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC maintains a database of over 1,500 volcano locations obtained from the Smithsonian Institution Global Volcanism Program, Volcanoes of the World publication. The...

  3. USAID Activity Locations

    Data.gov (United States)

    US Agency for International Development — The USAID Activities dataset is a snapshot of activities supported by USAID including their geographical locations within countries at the time of the snapshot. The...

  4. Uranium Location Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — A GIS compiled locational database in Microsoft Access of ~15,000 mines with uranium occurrence or production, primarily in the western United States. The metadata...

  5. Location-based Scheduling

    DEFF Research Database (Denmark)

    Andersson, Niclas; Christensen, Knud

    on the market. However, CPM is primarily an activity based method that takes the activity as the unit of focus and there is criticism raised, specifically in the case of construction projects, on the method for deficient management of construction work and continuous flow of resources. To seek solutions...... to the identified limitations of the CPM method, an alternative planning and scheduling methodology that includes locations is tested. Location-based Scheduling (LBS) implies a shift in focus, from primarily the activities to the flow of work through the various locations of the project, i.e. the building. LBS uses...... the graphical presentation technique of Line-of-balance, which is adapted for planning and management of work-flows that facilitates resources to perform their work without interruptions caused by other resources working with other activities in the same location. As such, LBS and Lean Construction share...

  6. AFRICOM: Does Location Matter?

    Science.gov (United States)

    2009-03-01

    Decision Model,” 242-244. 26 Susan Hesse Owen & Mark S. Daskin , “Strategic Facility Location: A Review,” European Journal of Operational Research...Susan Hesse & Mark S. Daskin . “Strategic Facility Location: A Review,” European Journal of Operational Research 111 (1998), 423-447. Paye-Layeleh...ES) N/ A 10. SPONSORING/MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this thesis are those of the author and

  7. On English Locative Subjects

    Directory of Open Access Journals (Sweden)

    Gabriela Brůhová

    2017-07-01

    Full Text Available The paper analyses English sentences with thematic locative subjects. These subjects were detected as translation counterparts of Czech sentenceinitial locative adverbials realized by prepositional phrases with the prepositions do (into, na (on, v/ve (in, z/ze (from complemented by a noun. In the corresponding English structure, the initial scene-setting adverbial is reflected in the thematic subject, which results in the locative semantics of the subject. The sentences are analysed from syntactic, semantic and FSP aspects. From the syntactic point of view, we found five syntactic patterns of the English sentences with a locative subject (SV, SVA, SVO, SVpassA and SVCs that correspond to Czech sentences with initial locative adverbials. On the FSP level the paper studies the potential of the sentences to implement the Presentation or Quality Scale. Since it is the “semantic content of the verb that actuates the presentation semantics of the sentence” (Duškova, 2015a: 260, major attention is paid to the syntactic-semantic structure of the verb. The analysis of the semantics of the English sentences results in the identification of two semantic classes of verbs which co-occur with the English locative subject.

  8. Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.

    Science.gov (United States)

    Ruhlen, Rachel L; Willbrand, Dana M; Besch-Williford, Cynthia L; Ma, Lixin; Shull, James D; Sauter, Edward R

    2009-10-01

    The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5-7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.

  9. A Policy Analysis and Quantitative Assessment of Key Issues Arising from Climate Change Negotiations Following COP 7

    Energy Technology Data Exchange (ETDEWEB)

    Sager, J. M

    2003-04-01

    This paper aims to assess the consequences of the amendments made to the Kyoto Protocol during COP 7 in Marrakech. Following a comprehensive policy analysis, the major issue of 'hot air' and CDM transaction costs is examined using the CERT model. This was done to show that primary supply regions, typically those with 'hot air' availability, might control the emissions reduction permit supply market and maximise net export revenues of permit supply by withholding 40 to 60% of available 'hot air' credits. The assumption that primary permit suppliers control permit price via a restriction of 'hot air' supply to the market will inadvertently leave a portion of the market share open to Non-Annex B CDM supply, despite potentially extreme variance in CDM transaction costs. A summary table of policy implications on the emissions reduction permit market is also included in the Appendix. (author)

  10. A Policy Analysis and Quantitative Assessment of Key Issues Arising from Climate Change Negotiations Following COP 7

    Energy Technology Data Exchange (ETDEWEB)

    Sager, J M

    2003-04-01

    This paper aims to assess the consequences of the amendments made to the Kyoto Protocol during COP 7 in Marrakech. Following a comprehensive policy analysis, the major issue of 'hot air' and CDM transaction costs is examined using the CERT model. This was done to show that primary supply regions, typically those with 'hot air' availability, might control the emissions reduction permit supply market and maximise net export revenues of permit supply by withholding 40 to 60% of available 'hot air' credits. The assumption that primary permit suppliers control permit price via a restriction of 'hot air' supply to the market will inadvertently leave a portion of the market share open to Non-Annex B CDM supply, despite potentially extreme variance in CDM transaction costs. A summary table of policy implications on the emissions reduction permit market is also included in the Appendix. (author)

  11. The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.

    Science.gov (United States)

    Meister, Cindy; Gulko, Miriam Kolog; Köhler, Anna M; Braus, Gerhard H

    2016-02-01

    The COP9 signalosome (CSN) and the proteasomal LID are conserved macromolecular complexes composed of at least eight subunits with molecular weights of approximately 350 kDa. CSN and LID are part of the ubiquitin–proteasome pathway and cleave isopeptide linkages of lysine side chains on target proteins. CSN cleaves the isopeptide bond of ubiquitin-like protein Nedd8 from cullins, whereas the LID cleaves ubiquitin from target proteins sentenced for degradation. CSN and LID are structurally and functionally similar but the order of the assembly pathway seems to be different. The assembly differs in at least the last subunit joining the pre-assembled subcomplex. This review addresses the similarities and differences in structure, function and assembly of CSN and LID.

  12. Contaminantes orgánicos persistentes (COPs en leche materna de centros urbanos de la provincia de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Lara Sofia Della Ceca

    2013-01-01

    Full Text Available Los contaminantes orgánicos persistentes (COPs se acumulan en matrices ricas en materia grasa como la leche materna, que es un buen indicador de sus niveles en poblaciones humanas debido a su fácil y no invasiva extracción. Con el objeto de evaluar la exposición a COPs en la provincia de Buenos Aires y compararla con otras  áreas, se analizaron bifenilos policlorados (PCBs, diclorodifeniltricloroetano (DDT y sus metabolitos (DDT, TDE, hexaclorociclohexanos (?, ? y ?-HCH y clordanos (CHLDs: heptaclor y su epóxido, trans y cis clordanos y nonaclors en muestras de leche materna colectadas durante 2010 y 2011 en Punta Lara, Ensenada, Florencio Varela y Capital Federal.Las  muestras fueron colectadas con sacaleches manuales, centrifugadas para separar la crema que fue liofilizada y extraída con éter de petróleo y ultrasonido. Los extractos previamente tratados con ácido para eliminación parcial de lípidos, fueron purificados por cromatografía en gel de sílice y analizados por cromatografía gaseosa.Las concentraciones de COPs en ng.g-1 lípido decrecieron en el orden DDTs (76±91 ? PCBs (67±64 > HCHs (33±36 ³ CHLDs (22±24.  Los DDTs oscilaron entre 7.7-510 ng.g-1 lípido y  los PCBs entre 5-247 ng.g-1 lípido, estos valores son comparables al rango más bajo reportado en la literatura (DDTs Noruega: 39-292 ng.g-1 lípido; PCBs Vietnam: 26-210 ng.g-1, Japón: 23-370 ng.g-1. En cambio, las concentraciones de HCHs y CHLDs, que oscilaron entre 5.8-197 ng.g-1 lípido y  1.3-124 ng.g-1 lípido respectivamente, corresponden al rango medio reportado para otras áreas (HCHs Indonesia 1.6-120 ng.g-1; CHLDs 3.4-92 ng.g-1. La composición de residuos en la leche materna es relativamente conservativa para cada clase de COPs, así se observa uniforme predominancia de productos de degradación (p.ej. DDE: 90±17% de SDDTs; epóxido de heptaclor: 50±18% y t-nonaclordano: 34±13% de SCHLDs y los isómeros y congéneres más persistentes (?-HCH

  13. Les chemins infinis de la décarbonisation. Neuf questions clés pour la COP21

    OpenAIRE

    Berta, Nathalie

    2015-01-01

    Introduction L’ouvrage de Michel Damian offre une analyse fine, à la fois riche et synthétique, des négociations climatiques internationales depuis la Convention-Cadre des Nations Unies de Rio en 1992. Ce détour historique est nécessaire si l’on veut comprendre les enjeux de la COP21 de Paris. Il permet de souligner l’évolution des thèmes abordés lors des négociations — de la réduction des émissions à l’adaptation, de la compensation des dommages liés au changement climatique au maintien du c...

  14. The Stability of Geometric Inference in Location Determination

    Science.gov (United States)

    1994-07-08

    environment, but not have a complete map of the surrounding terrain. Gallistel [ Gallistel , 1990] claims that the popular belief that the cognitive maps of...considering that an error of in the sun’s azimuth will put a navigator off by 100 km. Gallistel believes that animals obtain direction from the...constellations used for navigation are learned by these birds as nestlings [ Gallistel , 1990]. Birds in different areas of the world learn different

  15. COP 20 in Lima: a tense rehearsal dinner where everyone ended up eating at the same table. Climate Brief no. 37

    International Nuclear Information System (INIS)

    Morel, Romain; Deheza, Mariana; Cochran, Ian; Leguet, Benoit

    2014-12-01

    COP20 in Lima was expected to put the negotiations on track to get an ambitious global agreement in Paris in December 2015. As a 'rehearsal dinner' for Paris Climate 2015, COP20 managed to keep and strengthen the hopes for a 'wedding' of interests with all parties sharing a table. COP 20 achieved its two key objectives: defining a framework - even if only indicative - for the submission of the countries' Intended Nationally Determined Contributions (INDCs), and a preview of the components of the draft negotiating text that will be discussed throughout 2015 on the way to Paris. Perhaps the most valuable input may be COP20's treatment - or rather the absence - of the Annex I/non-Annex I differentiation. This marks a watershed moment in negotiations where all countries recognize the need to contribute to climate action. 2014 was a relatively productive year marked by Europe's engagement through the Energy Climate Package 2030, the US-China agreement and the capitalization of the Green Climate Fund. Nevertheless, many unsolved critical issues remain on the negotiator's plate to ensure the strong commitments necessary in Paris to reach the ambitious long-term 2 deg. C target. (authors)

  16. A Critical Review of the Use of Wenger's Community of Practice (CoP) Theoretical Framework in Online and Blended Learning Research, 2000-2014

    Science.gov (United States)

    Smith, Sedef Uzuner; Hayes, Suzanne; Shea, Peter

    2017-01-01

    After presenting a brief overview of the key elements that underpin Etienne Wenger's communities of practice (CoP) theoretical framework, one of the most widely cited and influential conceptions of social learning, this paper reviews extant empirical work grounded in this framework to investigate online/blended learning in higher education and in…

  17. Second-law-based analysis of vapor-compression refrigeration cycles: Analytical equations for COP and new insights into features of refrigerants

    International Nuclear Information System (INIS)

    Ma, Weiwu; Fang, Song; Su, Bo; Xue, Xinpei; Li, Min

    2017-01-01

    Highlights: • Second-law analysis leads to analytical COP formulas for refrigeration cycles. • Relative errors of the analytical equations are smaller than ±5.0%. • The analytical expressions characterize the influence of refrigerants. • Global entropy analysis elucidates the impact of cycle processes on COP. - Abstract: This article reports a second-law-based analysis of the vapor-compression refrigeration cycle, which leads to a set of explicit theoretical formulas for the coefficient of performance (COP). These analytical expressions provide a fast and accurate approach to computer simulations of the vapor-compression cycle without recourse to thermodynamic diagrams or equations of state. The second-law-based analysis yields specific expressions for the entropy generations of irreversible processes, enabling us to evaluate the thermodynamic features of the refrigerant and to elucidate the thermodynamic mechanisms behind the effects of the cycle processes, including superheat, subcooling, and throttling processes. In particular, these processes can interact, therefore this paper presents a global entropy generation analysis for evaluating the impact of the interacted processes on COP.

  18. Reconstructed phase spaces of intrinsic mode functions. Application to postural stability analysis.

    Science.gov (United States)

    Snoussi, Hichem; Amoud, Hassan; Doussot, Michel; Hewson, David; Duchêne, Jacques

    2006-01-01

    In this contribution, we propose an efficient nonlinear analysis method characterizing postural steadiness. The analyzed signal is the displacement of the centre of pressure (COP) collected from a force plate used for measuring postural sway. The proposed method consists of analyzing the nonlinear dynamics of the intrinsic mode functions (IMF) of the COP signal. The nonlinear properties are assessed through the reconstructed phase spaces of the different IMFs. This study shows some specific geometries of the attractors of some intrinsic modes. Moreover, the volume spanned by the geometric attractors in the reconstructed phase space represents an efficient indicator of the postural stability of the subject. Experiments results corroborate the effectiveness of the method to blindly discriminate young subjects, elderly subjects and subjects presenting a risk of falling.

  19. General minisum circle location

    DEFF Research Database (Denmark)

    Körner, Mark; Brimberg, Jack; Juel, Henrik

    2009-01-01

    In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points is minim......In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points...

  20. Location-based games

    DEFF Research Database (Denmark)

    Ejsing-Duun, Stine

    In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception of and be...... possible. The practical contribution is my creation of the LBG Visions of Sara. People continue to play this game in Odense more than two years after its launch, and DJEEO uses it as a showcase, enabling the company to sell similar LBGs....

  1. C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein

    Science.gov (United States)

    Cloix, Catherine; Kaiserli, Eirini; Heilmann, Monika; Baxter, Katherine J.; Brown, Bobby A.; O’Hara, Andrew; Smith, Brian O.; Christie, John M.; Jenkins, Gareth I.

    2012-01-01

    UV-B light initiates photomorphogenic responses in plants. Arabidopsis UV RESISTANCE LOCUS8 (UVR8) specifically mediates these responses by functioning as a UV-B photoreceptor. UV-B exposure converts UVR8 from a dimer to a monomer, stimulates the rapid accumulation of UVR8 in the nucleus, where it binds to chromatin, and induces interaction of UVR8 with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), which functions with UVR8 to control photomorphogenic UV-B responses. Although the crystal structure of UVR8 reveals the basis of photoreception, it does not show how UVR8 initiates signaling through interaction with COP1. Here we report that a region of 27 amino acids from the C terminus of UVR8 (C27) mediates the interaction with COP1. The C27 region is necessary for UVR8 function in the regulation of gene expression and hypocotyl growth suppression in Arabidopsis. However, UVR8 lacking C27 still undergoes UV-B–induced monomerization in both yeast and plant protein extracts, accumulates in the nucleus in response to UV-B, and interacts with chromatin at the UVR8-regulated ELONGATED HYPOCOTYL5 (HY5) gene. The UV-B–dependent interaction of UVR8 and COP1 is reproduced in yeast cells and we show that C27 is both necessary and sufficient for the interaction of UVR8 with the WD40 domain of COP1. Furthermore, we show that C27 interacts in yeast with the REPRESSOR OF UV-B PHOTOMORPHOGENESIS proteins, RUP1 and RUP2, which are negative regulators of UVR8 function. Hence the C27 region has a key role in UVR8 function. PMID:22988111

  2. STABILITY SYSTEMS VIA HURWITZ POLYNOMIALS

    Directory of Open Access Journals (Sweden)

    BALTAZAR AGUIRRE HERNÁNDEZ

    2017-01-01

    Full Text Available To analyze the stability of a linear system of differential equations  ẋ = Ax we can study the location of the roots of the characteristic polynomial pA(t associated with the matrix A. We present various criteria - algebraic and geometric - that help us to determine where the roots are located without calculating them directly.

  3. Effect of Symmetry Improvement in Weight Bearing on Postural Stability of Hemiparetic Patients

    Directory of Open Access Journals (Sweden)

    Hossein Asghar-Hosseini

    2008-07-01

    Full Text Available Objective: Impaired postural control has been known as the main cause of fall in hemiparesis after stroke. Is Asymmetry of weight bearing on lower limb is one of the prominent characteristics of postural imbalance in these patients. The aim of this study was to evaluate the effect of symmetry improvement in weight bearing through therapeutic interventions on postural stability in hemiparetic patients. Materials & Methods: In this quasi – experimental study which 27 hemiparetic patients were selected through sample of convenience by simple method from men and women who were referred to neurology clinic of Hazrat-e-Rasool hospital. For postural assessment patients stood quietly with open eyes and close eyes on force plates. Primary assessments included evaluation of asymmetry index (AI, RMS COP displacement (Root Mean Square of Center of Pressure and RMS COP velocity in both frontal and sagital planes. Then a 10mm lift was inserted under the unaffected limb and primary assessments were repeated. Data were analyzed by repeated measure ANOVA test. Results: Simple main effect of lift on asymmetry index was significant (P<0/0001. There was no significant interaction between vision and lift. Simple main effect of lift on postural stability variables was also non significant (for RMS COP displacement in frontal and sagital planes P=0.186 and P=0.245, respectively and for RMS COP velocity P=0.259 and P=0.342 respectively. Conclusion: Inserting a lift can improve symmetry by shifting center of gravity to midline. Since symmetry improvement did not decrease postural instability, asymmetric weight bearing can not be the primary cause of postural instability and may not be the principal target of rehabilitation programs aiming at restoring standing balance after stroke.

  4. The Czech Locative Chameleon

    Directory of Open Access Journals (Sweden)

    Tarald Taraldsen

    2007-12-01

    Full Text Available We show that under certain circumstances, the Czech locative prepositions (LOC show up as directional prepositions (DIR and vice versa, (under different circumstances the Czech DIR PPs show up as LOC. We argue that such a chameleon life of the PPs is structurally dependent.

  5. Immigrants' location preferences

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    This paper exploits a spatial dispersal policy for refugee immigrants to estimate the importance of local and regional factors for refugees' location preferences. The main results of a mixed proportional hazard competing risks model are that placed refugees react to high regional unemployment...

  6. Tracking, say, SKYPE Locations

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. Tracking, say, SKYPE Locations. Real Time Communication: Peer-to-Peer (P2P). Datagram flows between the two conversing partners; Exposes the IP addresses of all the participants to one another. If A knows B's VoIP ID, she can establish a call with Bob & obtain his current ...

  7. Spatiotemporal AED Location Optimization

    NARCIS (Netherlands)

    Chan, Timothy C.Y.; Sun, Christopher L.F.; Demirtas, Derya; Morrison, Laurie J.; Brooks, Steven C.

    2015-01-01

    Background: Mathematical optimization can be used to plan future AED placement to maximize out-of-hospital cardiac arrest (OHCA) coverage. Many public access AEDs are placed in locations without 24/7 access. AED coverage can be overestimated unless temporal availability is considered. Objective: To

  8. Location of New Firms

    DEFF Research Database (Denmark)

    Backman, Mikaela; Karlsson, Charlie

    2017-01-01

    characteristics, such as the commuting experience. Our results show that commuting influences the firm location choice. The probability of establishing a firm in the work municipality increases if the entrepreneur is a commuter, holding constant the type of region and unobservable and observable individual...

  9. Aquatic Nuisance Species Locator

    Science.gov (United States)

    Data in this map has been collected by the United States Geological Survey's Nonindigenous Aquatic Species program located in Gainesville, Florida (http://nas.er.usgs.gov/default.aspx). This dataset may have some inaccuracies and is only current to June 15, 2012. The species identified in this dataset are not inclusive of all aquatic nuisance species, but rather a subset identified to be at risk for transport by recreational activities such as boating and angling. Additionally, the locations where organisims have been identified are also not inclusive and should be treated as a guide. Organisms are limited to the following: American bullfrog, Asian clam, Asian shore crab, Asian tunicate, Australian spotted jellyfish, Chinese mitten crab, New Zealand mudsnail, Colonial sea squirt, Alewife, Bighead carp, Black carp, Flathead catfish, Grass carp, Green crab, Lionfish, Northern snakehead, Quagga mussel, Round Goby, Ruffe, Rusty crayfish, Sea lamprey, Silver carp, Spiny water flea, Veined rapa whelk, Zebra mussel

  10. Locating underground uranium deposits

    International Nuclear Information System (INIS)

    Felice, P.E.

    1979-01-01

    Underground uranium deposits are located by placing wires of dosimeters each about 5 to 18 mg/cm 2 thick underground in a grid pattern. Each dosimeter contains a phosphor which is capable of storing the energy of alpha particles. In each pair one dosimeter is shielded from alpha particles with more than 18 mg/cm 2 thick opaque material but not gamma and beta rays and the other dosimeter is shielded with less than 1 mg/cm 2 thick opaque material to exclude dust. After a period underground the dosimeters are heated which releases the stored energy as light. The amount of light produced from the heavily shielded dosimeter is subtracted from the amount of light produced from the thinly shielded dosimeter to give an indication of the location and quantity of uranium underground

  11. Web cache location

    Directory of Open Access Journals (Sweden)

    Boffey Brian

    2004-01-01

    Full Text Available Stress placed on network infrastructure by the popularity of the World Wide Web may be partially relieved by keeping multiple copies of Web documents at geographically dispersed locations. In particular, use of proxy caches and replication provide a means of storing information 'nearer to end users'. This paper concentrates on the locational aspects of Web caching giving both an overview, from an operational research point of view, of existing research and putting forward avenues for possible further research. This area of research is in its infancy and the emphasis will be on themes and trends rather than on algorithm construction. Finally, Web caching problems are briefly related to referral systems more generally.

  12. Location based services

    OpenAIRE

    Doan, Cong Nam

    2015-01-01

    Mobile devices (tablets, smart phones, laptops) are proving themselves to be the main means of accessing information of the future. The embodiment of Recommender Systems (RSs) into mobile environments, as a matter of fact, has come about to serve as a way to solve the nuisances of data overwhelming. RSs' main advantage is their ability to allow users to find useful information according to the users' preferences and location. Even though they are not free of shortcoming such as the limitation...

  13. Location Intelligence Solutions

    International Nuclear Information System (INIS)

    Schmidt, D.

    2015-01-01

    Location Intelligence (LI) means using the spatial dimension of information as a key to support business processes. This spatial dimension has to be defined by geographic coordinates. Storing these spatial objects in a database allows for attaching a 'meaning' to them, like 'current position', 'border', 'building' or 'room'. Now the coordinates represent real-world objects, which can be relevant for the measurement, documentation, control or optimization of (parameters of) business processes aiming at different business objectives. But LI can only be applied, if the locations can be determined with an accuracy (in space and time) appropriate for the business process in consideration. Therefore the first step in any development of a LI solution is the analysis of the business process itself regarding its requirements for spatial and time resolution and accuracy. The next step is the detailed analysis of the surrounding conditions of the process: Does the process happen indoor and/or outdoor? Are there moving objects? If yes, how fast are they? How does the relevant environment look like? Is technical infrastructure available? Is the process restricted by regulations? As a result, a proper Location Detection Technology (LDT) has to be chosen in order to get reliable and accurate positions of the relevant objects. At the highly challenging conditions of the business processes IAEA inspectors are working with, the chosen LDTs have to deliver reliable positioning on ''room-level'' accuracy, even if there is no location enabling infrastructure in place, the objects (people) mostly are indoors and have to work under strong regulations. The presentation will give insights into innovative LI solutions based on technologies of different LDT providers. Pros and cons of combinations of different LDT (like multi- GNSS, IMU, camera, and human interaction based positioning) will be discussed from the

  14. Ammonia Leak Locator Study

    Science.gov (United States)

    Dodge, Franklin T.; Wuest, Martin P.; Deffenbaugh, Danny M.

    1995-01-01

    The thermal control system of International Space Station Alpha will use liquid ammonia as the heat exchange fluid. It is expected that small leaks (of the order perhaps of one pound of ammonia per day) may develop in the lines transporting the ammonia to the various facilities as well as in the heat exchange equipment. Such leaks must be detected and located before the supply of ammonia becomes critically low. For that reason, NASA-JSC has a program underway to evaluate instruments that can detect and locate ultra-small concentrations of ammonia in a high vacuum environment. To be useful, the instrument must be portable and small enough that an astronaut can easily handle it during extravehicular activity. An additional complication in the design of the instrument is that the environment immediately surrounding ISSA will contain small concentrations of many other gases from venting of onboard experiments as well as from other kinds of leaks. These other vapors include water, cabin air, CO2, CO, argon, N2, and ethylene glycol. Altogether, this local environment might have a pressure of the order of 10(exp -7) to 10(exp -6) torr. Southwest Research Institute (SwRI) was contracted by NASA-JSC to provide support to NASA-JSC and its prime contractors in evaluating ammonia-location instruments and to make a preliminary trade study of the advantages and limitations of potential instruments. The present effort builds upon an earlier SwRI study to evaluate ammonia leak detection instruments [Jolly and Deffenbaugh]. The objectives of the present effort include: (1) Estimate the characteristics of representative ammonia leaks; (2) Evaluate the baseline instrument in the light of the estimated ammonia leak characteristics; (3) Propose alternative instrument concepts; and (4) Conduct a trade study of the proposed alternative concepts and recommend promising instruments. The baseline leak-location instrument selected by NASA-JSC was an ion gauge.

  15. Dynamic postural stability during advancing pregnancy.

    Science.gov (United States)

    McCrory, J L; Chambers, A J; Daftary, A; Redfern, M S

    2010-08-26

    Pregnant women are at an increased risk of experiencing a fall. Numerous anatomical, physiological, and hormonal alterations occur during pregnancy, but the influence of these factors on dynamic postural stability has not been explored. The purpose of this study was to examine dynamic postural stability in pregnant women during their second and third trimesters as well as in a group of non-pregnant control women. Eighty-one women (41 pregnant, 40 controls) participated stood on a force plate that translated anteroposteriorly at small, medium, and large magnitudes. Reaction time and center of pressure (COP) movement during the translations were analyzed. Trimester, perturbation direction, and perturbation magnitude were the independent variables in a mixed-model analysis of variance on each of the following dependent variables: reaction time, initial sway, total sway, and sway velocity. Reaction time to the perturbation was not significantly different between the groups. Initial sway, total sway, and sway velocity were significantly less during the third trimester than during the second trimester and when compared to the non-pregnant controls (Ppostural stability. 2010 Elsevier Ltd. All rights reserved.

  16. Reducing emissions from deforestation and degradation in developing countries (REDD): insights from the UNFCCC COP-13 in Bali

    International Nuclear Information System (INIS)

    Wertz-Kanounnikoff, S.

    2007-01-01

    At the 10. anniversary of the Kyoto Protocol, the goal to reduce greenhouse gas (GHG) emissions that cause climate change remains of alarming importance. According to the Intergovernmental Panel on Climate Change, these emissions have grown by 70% since 1970; and in 2005 the concentration of the most important GHG, carbon dioxide (CO 2 ), peaked at its highest level for 650,000 years (IPCC 2007). The proposal to compensate reduced emissions from deforestation and degradation in developing countries (REDD), as an additional element in the international climate regime, was put forward to address the so far ignored up to 20% of global GHG emissions arising from forestry. Although excluded from the first commitment period of the Kyoto Protocol, the idea was submitted by Papua New Guinea and Costa Rica, on behalf of the Coalition of Rain forest Nations, at the 11. Conference of Parties (COP-11) to the UN Framework Convention on Climate Change in Montreal in 2005. The proposal has initiated a two year examination process, facilitated by the UNFCCC, and has attracted extremely high participation levels of the concerned stakeholders. As the examination process on REDD took place between 2005 and 2007, several points of agreement and disagreement were being revealed among the different country proposals. Points of agreement included inter alia: that REDD would need to play a role in future climate regimes; that there was a need to take into account national circumstances to successfully integrate developing countries; and capacity-building and pilot or demonstration activities (prior to 2012) are crucial to enable developing countries to effectively participate and benefit from REDD. Points of contention consisted in inter alia: the potential financing systems (market- or fund/ODA-based), the scope of activity (deforestation only or with forest degradation or with forest conservation), and the scale of implementation (national or project level). Decisive advance on the

  17. Survey report for fiscal 1998. Evaluation by industrial circles of the COP3 outcome and their future response (America); 1998 nendo chosa hokokusho. COP3 no kekka ni taisuru sangyokai no hyoka oyobi kongo no taio ni tsuite (Beikoku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Response in America to COP3 (Third Session of the Conference of the Parties to the United Nations Framework Convention on Climate Change) is investigated. Office of Energy Efficiency and Renewable Energy (EE) of America's Department of Energy conducts activities designed to protect environments and supports America's economic competitiveness. The scope of EE activities is quite wide, covering efforts at energy efficiency improvement and renewal energy utilization for all energy consuming sectors involving construction work and equipment for buildings, various industries and public utility works, and transportation. EE also supports and promotes the development of advanced industrial materials, electric vehicles, hybrid vehicles, fuel cells, etc. In the field of renewable energy, it deals with the exploitation of sunlight, biomass, wind force, water power, geothermal energy, etc. It also supports efficiency improvement efforts being undertaken through studies of advanced power transmission and distribution, high-temperature superconduction, energy storage, etc. The said supports are provided not only by Federal Government but also by state governments, and include financial aids. A number of programs are under way, worked out and promoted by the respective bureaus and departments. They are evaluated, protected, and implemented through the partnership of official and civilian organizations. (NEDO)

  18. Stabilizing Niger

    DEFF Research Database (Denmark)

    Hahonou, Eric Komlavi

    international intervention in Niger. Their main objective is to secure their own strategic, economic and political interests by strengthening the Nigerien authorities through direct intervention and capacity building activities. For western states reinforcing state security institutions and stabilizing elite...

  19. Location Privacy with Randomness Consistency

    Directory of Open Access Journals (Sweden)

    Wu Hao

    2016-10-01

    Full Text Available Location-Based Social Network (LBSN applications that support geo-location-based posting and queries to provide location-relevant information to mobile users are increasingly popular, but pose a location-privacy risk to posts. We investigated existing LBSNs and location privacy mechanisms, and found a powerful potential attack that can accurately locate users with relatively few queries, even when location data is well secured and location noise is applied. Our technique defeats previously proposed solutions including fake-location detection and query rate limits.

  20. Indoor Location Technologies

    CERN Document Server

    Goswami, Subrata

    2013-01-01

    Focusing on the special challenges posed by accurately pinpointing a location indoors, this volume reflects the distance we have come in the handful of decades since the germination of GPS technology. Not only can we locate a signal to within a meter’s accuracy, but we now have this technology in the most basic mobile phone. Tracing recent practical developments in positioning technology and in the market it supplies, the author examines the contributions of the varied research—in silicon, signal and image processing, radio communications and software—to a fast-evolving field. The book looks forward to a time when, in addition to directing your road journey, positioning systems can peer indoors and guide you to an available photocopier in your office building. Featuring standalone chapters each dealing with a specific aspect of the subject, including treatments of systems such as Zebra, Awarepoint, Aeroscout, IEEE 802.11, etc. This study has all the detail needed to get up to speed on a key modern techn...

  1. Comparative strength analysis and thermal fatigue testing of Be/CuCrZr and Be/GlidCop joints produced by fast brazing

    International Nuclear Information System (INIS)

    Gervash, A.; Mazul, I.; Yablokov, N.; Barabash, V.; Ganenko, A.

    2000-01-01

    Proposing beryllium as plasma facing armour this paper presents the recent results obtained in Russia in the frame of such activities. Last year testing of actively cooled mock-ups produced by fast brazing of Be onto Cu-alloy heat sink allows to consider mentioned Russian method as promising for both PH-copper like CuCrZr and DS-copper like GlidCop. Summarizing recent experimental results with their previous data authors attempt to comparatively investigate a behaviour of Be/CuCrZr and Be/GlidCop joints in ITER relevant conditions. Mechanical properties, brazing zone microstructure and thermal response were taken for comparison. The shear strength for both types of joints was found as 150-200 MPa and did not depend on testing temperature. The brazing zone morphology and microhardness are presented, the thermal fatigue behaviour of investigated joints is described. All main results as well as the nearest future plans are discussed. (orig.)

  2. A Engenharia de Sistemas e a Gestão de Cops como Ferramentas da Gestão de Projetos Complexos na Área de TI

    Directory of Open Access Journals (Sweden)

    José Eduardo de Figueiredo Freitas

    2008-04-01

    Full Text Available The present work deals with a case study, in order to validate the application of two theories – Complex Products and Systems (CoPS and Systems Engineering– as modern tools for complex projects management in the Information Technology (IT field. In particular, it is intended to show the use of those tools for the parameters definition of a big Communications Network, in the project phase. The project of the Brazilian Army Corporate Communications Network (EBNet has been chosen as the object for the mentioned case study; one of the biggest networks of this nature in the country, an admittedly complex project. The project of the EBNet has been analyzed by the view point of Complex Systems - CoPS - and Systems Engineering theories, and we conclude by analyzing the validity of these theories as modern tools for the manager of complex projects in the IT field.

  3. A quantitative study of valence electron transfer in the skutterudite compound CoP3 by combining x-ray induced Auger and photoelectron spectroscopy

    International Nuclear Information System (INIS)

    Diplas, S; Prytz, Oe; Karlsen, O B; Watts, J F; Taftoe, J

    2007-01-01

    We use the sum of the ionization and Auger energy, the so-called Auger parameter, measured from the x-ray photoelectron spectrum, to study the valence electron distribution in the skutterudite CoP 3 . The electron transfer between Co and P was estimated using models relating changes in Auger parameter values to charge transfer. It was found that each P atom gains 0.24 e - , and considering the unit formula CoP 3 this is equivalent to a donation of 0.72 e - per Co atom. This is in agreement with a recent electron energy-loss spectroscopy study, which indicates a charge transfer of 0.77 e - /atom from Co to P

  4. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.

    Science.gov (United States)

    Yu, Jianxiu; Deng, Rong; Zhu, Helen H; Zhang, Sharon S; Zhu, Changhong; Montminy, Marc; Davis, Roger; Feng, Gen-Sheng

    2013-02-08

    The Src-homology 2 (SH2) domain-containing tyrosine phosphatase Shp2 has been known to regulate various signaling pathways triggered by receptor and cytoplasmic tyrosine kinases. Here we describe a novel function of Shp2 in control of lipid metabolism by mediating degradation of fatty acid synthase (FASN). p38-phosphorylated COP1 accumulates in the cytoplasm and subsequently binds FASN through Shp2 here as an adapter, leading to FASN-Shp2-COP1 complex formation and FASN degradation mediated by ubiquitination pathway. By fasting p38 is activated and stimulates FASN protein degradation in mice. Consistently, the FASN protein levels are dramatically elevated in mouse liver and pancreas in which Shp2/Ptpn11 is selectively deleted. Thus, this study identifies a new activity for Shp2 in lipid metabolism.

  5. Effect of cognitive and motor tasks on postural stability in Parkinson's disease: a posturographic study.

    Science.gov (United States)

    Marchese, Roberta; Bove, Marco; Abbruzzese, Giovanni

    2003-06-01

    To analyse the effect of concomitant cognitive or motor task performance on balance control in Parkinson's disease (PD), we performed a posturographic study in 24 PD patients and in 20 sex- and age-matched control subjects. Postural sway was measured with eyes open (EO) and eyes closed (EC) during quiet stance and during performance of calculation or motor sequence of thumb opposition to the other fingers. No difference of centre of foot pressure (COP) parameters was observed during quiet standing (either EO or EC) between patients and controls, but visual deprivation induced in both groups a worsening of postural stability. COP area was significantly increased in PD patients during dual task performance, whereas no difference of COP path and x-y axes was observed. The effects induced by the performance of cognitive or motor task were significantly more evident in PD patients with clinical evidence of postural instability (presence of prior falls in the history). This study demonstrates that dual task interference on postural control can be observed in PD patients during performance of cognitive as well as motor tasks. The balance deterioration during dual task performance was significantly enhanced in patients with history of prior falls. These findings have some implications for the strategies to be used in reducing the risk of fall in PD. Copyright 2003 Movement Disorder Society

  6. Methodologically Sound: Evaluating the Psychometric Approach to the Assessment of Human Life History [Reply to Copping, Campbell, and Muncer, 2014

    Science.gov (United States)

    Cabeza de Baca, Tomás; Black, Candace Jasmine; García, Rafael Antonio; Fernandes, Heitor Barcellos Ferreira; Wolf, Pedro Sofio Abril; Woodley of Menie, Michael Anthony

    2016-01-01

    Copping, Campbell, and Muncer (2014) have recently published an article critical of the psychometric approach to the assessment of life history (LH) strategy. Their purported goal was testing for the convergent validation and examining the psychometric structure of the High-K Strategy Scale (HKSS). As much of the literature on the psychometrics of human LH during the past decade or so has emanated from our research laboratory and those of close collaborators, we have prepared this detailed response. Our response is organized into four main sections: (1) A review of psychometric methods for the assessment of human LH strategy, expounding upon the essence of our approach; (2) our theoretical/conceptual concerns regarding the critique, addressing the broader issues raised by the critique regarding the latent and hierarchical structure of LH strategy; (3) our statistical/methodological concerns regarding the critique, examining the validity and persuasiveness of the empirical case made specifically against the HKSS; and (4) our recommendations for future research that we think might be helpful in closing the gap between the psychometric and biometric approaches to measurement in this area. Clearly stating our theoretical positions, describing our existing body of work, and acknowledgintheir limitations should assist future researchers in planning and implementing more informed and prudent empirical research that will synthesize the psychometric approach to the assessment of LH strategy with complementary methods. PMID:25844774

  7. Methodologically Sound: Evaluating the Psychometric Approach to the Assessment of Human Life History [Reply to Copping, Campbell, and Muncer, 2014

    Directory of Open Access Journals (Sweden)

    Aurelio José Figueredo

    2015-04-01

    Full Text Available Copping, Campbell, and Muncer (2014 have recently published an article critical of the psychometric approach to the assessment of life history (LH strategy. Their purported goal was testing for the convergent validation and examining the psychometric structure of the High-K Strategy Scale (HKSS. As much of the literature on the psychometrics of human LH during the past decade or so has emanated from our research laboratory and those of close collaborators, we have prepared this detailed response. Our response is organized into four main sections: (1 A review of psychometric methods for the assessment of human LH strategy, expounding upon the essence of our approach; (2 our theoretical/conceptual concerns regarding the critique, addressing the broader issues raised by the critique regarding the latent and hierarchical structure of LH strategy; (3 our statistical/methodological concerns regarding the critique, examining the validity and persuasiveness of the empirical case made specifically against the HKSS; and (4 our recommendations for future research that we think might be helpful in closing the gap between the psychometric and biometric approaches to measurement in this area. Clearly stating our theoretical positions, describing our existing body of work, and acknowledging their limitations should assist future researchers in planning and implementing more informed and prudent empirical research that will synthesize the psychometric approach to the assessment of LH strategy with complementary methods.

  8. Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

    Science.gov (United States)

    Scherer, Paul C; Ding, Yan; Liu, Zhiqing; Xu, Jing; Mao, Haibin; Barrow, James C; Wei, Ning; Zheng, Ning; Snyder, Solomon H; Rao, Feng

    2016-03-29

    The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains poorly understood. Inositol polyphosphates are highly conserved signaling molecules implicated in diverse cellular processes. We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes a hitherto unidentified electrostatic interaction between the N-terminal acidic tail of CSN subunit 2 (CSN2) and a conserved basic canyon on cullins. IP6, with an EC50 of 20 nM, acts as an intermolecular "glue," increasing cullin-CSN2 binding affinity by 30-fold, thereby promoting assembly of the inactive CRL-CSN complexes. The IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. Besides dysregulating CRL-mediated cell proliferation and UV-induced apoptosis, IP5K depletion potentiates by 28-fold the cytotoxic effect of the neddylation inhibitor MLN4924. Thus, IP5K and IP6 are evolutionarily conserved components of the CRL-CSN system and are potential targets for cancer therapy in conjunction with MLN4924.

  9. Seismic and Infrasound Location

    Energy Technology Data Exchange (ETDEWEB)

    Arrowsmith, Stephen J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Begnaud, Michael L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-03-19

    This presentation includes slides on Signal Propagation Through the Earth/Atmosphere Varies at Different Scales; 3D Seismic Models: RSTT; Ray Coverage (Pn); Source-Specific Station Corrections (SSSCs); RSTT Conclusions; SALSA3D (SAndia LoS Alamos) Global 3D Earth Model for Travel Time; Comparison of IDC SSSCs to RSTT Predictions; SALSA3D; Validation and Model Comparison; DSS Lines in the Siberian Platform; DSS Line CRA-4 Comparison; Travel Time Δak135; Travel Time Prediction Uncertainty; SALSA3D Conclusions; Infrasound Data Processing: An example event; Infrasound Data Processing: An example event; Infrasound Location; How does BISL work?; BISL: Application to the 2013 DPRK Test; and BISL: Ongoing Research.

  10. Demographics and remote locations

    Energy Technology Data Exchange (ETDEWEB)

    Coppus, G. [Dynawise Inc., Calgary, AB (Canada)

    2005-07-01

    Within the next decade, the number of people leaving the workforce will exceed the number of new entrants. The demand for workers is expected to increase in Alberta due to oil sands industry growth. Sixty-four per cent of all responding federal, provincial, and municipal government organizations have reported shortages in their work environments, and almost 8 in 10 organizations predict they will continue to be understaffed in the next 3 to 5 years. Tightness in the general labour market will have an impact on employers in remote locations, and planning is essential to avoid the creation of a mercenary culture and a reliance on compensation. Challenges found in remote locations include high turnover rates among recent hires; critical gaps in service length; aggressive retirement; and the fact that the local population is often seen as unqualified for many industrial jobs. This Power Point presentation suggested that although decisions to join or quit a company are often based on considerations such as the organizational environment and amount of compensation, the relationship between employees and management is the most important attribute in many career decisions. Rigorous quantitative analysis of current demographics combined with forecasting analysis may help to forestall recruitment difficulties for many companies. Productivity analyses, and the effects of work overload on absenteeism, attrition and quality of workmanship must also be examined. Many companies are now focusing on retention and development strategies on mid-career staff to address depletion, as well as redesigning procedures to operate with less skilled staff. It was concluded that extra efforts are now being made to attract non-traditional employees, and non-traditional employment models are being considered by some companies. refs., tabs., figs.

  11. Development and psychometric testing of the childhood obesity perceptions (COP) survey among African American caregivers: A tool for obesity prevention program planning.

    Science.gov (United States)

    Alexander, Dayna S; Alfonso, Moya L; Cao, Chunhua

    2016-12-01

    Currently, public health practitioners are analyzing the role that caregivers play in childhood obesity efforts. Assessing African American caregiver's perceptions of childhood obesity in rural communities is an important prevention effort. This article's objective is to describe the development and psychometric testing of a survey tool to assess childhood obesity perceptions among African American caregivers in a rural setting, which can be used for obesity prevention program development or evaluation. The Childhood Obesity Perceptions (COP) survey was developed to reflect the multidimensional nature of childhood obesity including risk factors, health complications, weight status, built environment, and obesity prevention strategies. A 97-item survey was pretested and piloted with the priority population. After pretesting and piloting, the survey was reduced to 59-items and administered to 135 African American caregivers. An exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) was conducted to test how well the survey items represented the number of Social Cognitive Theory constructs. Twenty items were removed from the original 59-item survey and acceptable internal consistency of the six factors (α=0.70-0.85) was documented for all scales in the final COP instrument. CFA resulted in a less than adequate fit; however, a multivariate Lagrange multiplier test identified modifications to improve the model fit. The COP survey represents a promising approach as a potentially comprehensive assessment for implementation or evaluation of childhood obesity programs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Report on the survey in fiscal 1998. Evaluation by the industry on the result of COP3 and the future activities in relation with the result of COP3 (Canada); 1998 nendo chosa hokokusho. COP3 no kekka ni taisuru sangyokai no hyoka oyobi kongo no taio ni tsuite (Canada)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    A survey was carried out on activities in Canada in relation with COP3. The Office of Energy Efficiency is promoting the energy efficiency improvement and substituting energy plan applicable to housings, commercial and manufacturing industries, public organizations and transportation department. It is also implementing a comprehensive plan incorporating consumer information, national energy utilization data base, and energy technology innovation initiative. The energy technology innovation plus plan strengthens coordination with industrial societies in each sector, and makes finances for improvement of energy efficiency. There is also an institution to promote energy efficiency improvement in newly built houses. The manufacturing industry energy technology innovation initiative is an institution to present means to transfer pledges in each department into a company-wide activity. In the energy conservation encouragement plan for commercial buildings, an annual federal fund of ten million dollars is allotted, and incentive money is paid. The automotive fuel consumption enhancement plan provides purchasers with fuel consumption information, and encourages production of energy saving cars. The substituting transportation fuel market developing initiative promotes development and utilization of methanol, ethanol, hydrogen, and electric power. (NEDO)

  13. Location constrained resource interconnection

    International Nuclear Information System (INIS)

    Hawkins, D.

    2008-01-01

    This presentation discussed issues related to wind integration from the perspective of the California Independent System Operator (ISO). Issues related to transmission, reliability, and forecasting were reviewed. Renewable energy sources currently used by the ISO were listed, and details of a new transmission financing plan designed to address the location constraints of renewable energy sources and provide for new transmission infrastructure was presented. The financing mechanism will be financed by participating transmission owners through revenue requirements. New transmission interconnections will include network facilities and generator tie-lines. Tariff revisions have also been implemented to recover the costs of new facilities and generators. The new transmission project will permit wholesale transmission access to areas where there are significant energy resources that are not transportable. A rate impact cap of 15 per cent will be imposed on transmission owners to mitigate short-term costs to ratepayers. The presentation also outlined energy resource area designation plans, renewable energy forecasts, and new wind technologies. Ramping issues were also discussed. It was concluded that the ISO expects to ensure that 20 per cent of its energy will be derived from renewable energy sources. tabs., figs

  14. On location at CERN

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    CERN continues to be a very popular candidate for film locations at the moment. Not only has it inspired a German author and a film-maker interested in the more exotic interpretations of the science being worked on at the Organization, but even the recent puppet animation film by the legendary Muppets featured some CERN scenes.   Dr Bunsen Honeydew (far left) and his friends at ATLAS. Beaker, Bunsen's assistant, has just been sucked up the vacuum tube top left... Image courtesy Walt Disney Studios. In “The Muppet Movie”, released in November 2011 in North America and world-wide in January and February this year, Kermit is reuniting his friends who have ended up in some far-flung places since they last worked together 10 years ago. CERN caught the imagination of the film-makers as the perfect place for the Muppet scientists, Dr. Honeydew Bunsen and his hapless assistant Beaker. After a brief scene filmed in front of a backdrop of the ATLAS detector, the rest of the ...

  15. Toward High-Performance and Low-Cost Hydrogen Evolution Reaction Electrocatalysts: Nanostructuring Cobalt Phosphide (CoP) Particles on Carbon Fiber Paper.

    Science.gov (United States)

    Yu, Shu Hearn; Chua, Daniel H C

    2018-05-02

    In this communication, we facily fabricated nanostructured CoP particles (150 to 200 nm) on carbon fiber paper (CFP) for hydrogen evolution reaction (HER) by a simple two-step process via a green route. In the first step, crystalline Co 3 O 4 nanocubes (150-200 nm) were loaded on CFP through a hydrothermal process at low temperature (120 °C). Interestingly, crystalline Co 3 O 4 nanocubes with a size 150-200 nm exhibited different growth mechanisms in contrast to the crystalline Co 3 O 4 nanocubes with a size <100 nm reported earlier. In the second step, these crystalline Co 3 O 4 nanocubes were converted to catalytically active CoP particles through chemical vapor deposition (CVD) phosphorization (denoted as CoP/CFP-H). Remarkably, CoP/CFP-H exhibited a low Tafel slope of 49.7 mV/dec and only required overpotentials of 128.1, 144.4, and 190.8 mV to drive geometric current densities of -10, -20, and -100 mA cm -2 , respectively. Besides, the CoP/CFP-H also demonstrated an excellent durability in an acidic environment under 2000 sweeps at a high scan rate (100 mV s -1 ) and a 24 h chronopotentiometry testing. For comparison, CoP was also fabricated through the electrodeposition method, followed by CVD phosphorization (denoted as CoP/CFP-E). It was found that the latter had exhibited inferior activity compared to CoP/CFP-H. The good performances of CoP/CFP-H are essentially due to the rational designs of electrode: (i) the applications of highly HER active CoP electrocatalyst, (ii) the intimate contact of nanostructured CoP on carbon fibers, and (iii) the large electrochemical surface area at electrocatalyst/electrolyte interface due to the large retaining of particles features after phosphorization. Notably, the intermediate Co 3 O 4 /CFP can serve as a platform to develop other cobalt-based functional materials.

  16. Costly location in Hotelling duopoly

    NARCIS (Netherlands)

    Hinloopen, J.; Martin, S.

    2013-01-01

    We introduce a cost of location into Hotelling’s (1929) spatial duopoly. We derive the general conditions on the cost-of-location function under which a pure strategy price-location Nash equilibrium exists. With linear transportation cost and a suitably specified cost of location that rises toward

  17. Costly location in Hotelling duopoly

    NARCIS (Netherlands)

    Hinloopen, J.; Martin, S.

    We introduce a cost of location into Hotelling's (1929) spatial duopoly model. We derive the general conditions on the cost-of-location function under which a pure strategy price-location Nash equilibrium exists. With linear transportation cost and a suitably specified cost of location that rises

  18. Test-retest reliability of the assessment of postural stability in typically developing children and in hearing impaired children.

    Science.gov (United States)

    De Kegel, A; Dhooge, I; Cambier, D; Baetens, T; Palmans, T; Van Waelvelde, H

    2011-04-01

    The purpose of this study was to establish test-retest reliability of centre of pressure (COP) measurements obtained by an AccuGait portable forceplate (ACG), mean COG sway velocity measured by a Basic Balance Master (BBM) and clinical balance tests in children with and without balance difficulties. 49 typically developing children and 23 hearing impaired children, with a higher risk for stability problems, between 6 and 12 years of age participated. Each child performed the modified Clinical Test of Sensory Interaction on Balance (mCTSIB), Unilateral Stance (US) and Tandem Stance on ACG, mCTSIB and US on BBM and clinical balance tests: one-leg standing, balance beam walking and one-leg hopping. All subjects completed 2 test sessions on 2 different days in the same week assessed by the same examiner. Among COP measurements obtained by the ACG, mean sway velocity was the most reliable parameter with all ICCs higher than 0.72. The standard deviation (SD) of sway velocity, sway area, SD of anterior-posterior and SD of medio-lateral COP data showed moderate to excellent reliability with ICCs between 0.55 and 0.96 but some caution must be taken into account in some conditions. BBM is less reliable but clinical balance tests are as reliable as ACG. Hearing impaired children exhibited better relative reliability (ICC) and comparable absolute reliability (SEM) for most balance parameters compared to typically developing children. Reliable information regarding postural stability of typically developing children and hearing impaired children may be obtained utilizing COP measurements generated by an AccuGait system and clinical balance tests. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. The Economics of Climate Change in Kenya: Final Report submitted in advance of COP15

    Energy Technology Data Exchange (ETDEWEB)

    Downing, Tom; Watkiss, Paul; Dyszynski, Jillian; Butterfield, Ruth; Devisscher, Tahia; Pye, Steve; Droogers, Peter; Ali, Basra; Harding, Brian; Tas, Adriaan; Blois, Mark de; Tadege, Abebe; Hunt, Alistair; Taylor, Tim; Bouma, Menno; Kovats, Sari; Maitima, Joseph; Mugatha, Simon; Kariuki, Patrick; Mariene, Lea; Worden, Jeff; Western, David; Waruingi, Lucy; Brown, Sally; Kebede, Abiy; Nicholls, Robert; Lager, Bo; Otiende, Brian; Chambwera, Muyeye; Birch, Tom; Mutimba, Stephen; Sang, Joan

    2009-12-15

    of greenhouse gases (GHG) could double between 2005 and 2030. Moreover, plans across the economy could 'lock-in' Kenya into a higher emission pathway. The study has investigated a low carbon alternative pathway. This finds that a large number of 'no regrets' options that would enhance economic growth, as well as allowing further access to international carbon credits. They also have economic benefits from greater energy security and diversity, reduced air pollution, reduced environmental impacts. The study estimates energy related emission savings of 22% could be achieved by 2020, relative to the baseline, even for a small selection of options. Over 80% of these options can be realized at net negative cost. When carbon credits are included, this amount is likely to be even higher. Overall, because of its location, availability of resources and socio-economic conditions, the study concludes that there are significant economic benefits for Kenya in following a low carbon development path, as well as large environmental and social benefits. The study has outlined a number of recommendations and future priorities

  20. The Economics of Climate Change in Kenya: Final Report submitted in advance of COP15

    Energy Technology Data Exchange (ETDEWEB)

    Downing, Tom; Watkiss, Paul; Dyszynski, Jillian; Butterfield, Ruth; Devisscher, Tahia; Pye, Steve; Droogers, Peter; Ali, Basra; Harding, Brian; Tas, Adriaan; Blois, Mark de; Tadege, Abebe; Hunt, Alistair; Taylor, Tim; Bouma, Menno; Kovats, Sari; Maitima, Joseph; Mugatha, Simon; Kariuki, Patrick; Mariene, Lea; Worden, Jeff; Western, David; Waruingi, Lucy; Brown, Sally; Kebede, Abiy; Nicholls, Robert; Lager, Bo; Otiende, Brian; Chambwera, Muyeye; Birch, Tom; Mutimba, Stephen; Sang, Joan

    2009-12-15

    of greenhouse gases (GHG) could double between 2005 and 2030. Moreover, plans across the economy could 'lock-in' Kenya into a higher emission pathway. The study has investigated a low carbon alternative pathway. This finds that a large number of 'no regrets' options that would enhance economic growth, as well as allowing further access to international carbon credits. They also have economic benefits from greater energy security and diversity, reduced air pollution, reduced environmental impacts. The study estimates energy related emission savings of 22% could be achieved by 2020, relative to the baseline, even for a small selection of options. Over 80% of these options can be realized at net negative cost. When carbon credits are included, this amount is likely to be even higher. Overall, because of its location, availability of resources and socio-economic conditions, the study concludes that there are significant economic benefits for Kenya in following a low carbon development path, as well as large environmental and social benefits. The study has outlined a number of recommendations and future priorities

  1. Macroeconomic stability

    DEFF Research Database (Denmark)

    Jespersen, Jesper

    2004-01-01

    It is demonstrated that full employment and sustainable development not necessarily are conflicting goals. On the other hand macroeconomic stability cannot be obtained without a deliberate labour sharing policy and a shift in the composition of private consumption away from traditional material...

  2. Stabilized superconductors

    International Nuclear Information System (INIS)

    Wong, J.

    1975-01-01

    The stable, high field, high current composite wire comprises multiple filaments in a depleted bronze matrix, each filament comprising a type II superconducting, beta-tungsten structure, intermetallic compound layer jacketing and metallurgically bonded to a stabilizing copper core, directly or via an intermediate layer of refractory metal

  3. Postural instability detection: aging and the complexity of spatial-temporal distributional patterns for virtually contacting the stability boundary in human stance.

    Directory of Open Access Journals (Sweden)

    Melissa C Kilby

    Full Text Available Falls among the older population can severely restrict their functional mobility and even cause death. Therefore, it is crucial to understand the mechanisms and conditions that cause falls, for which it is important to develop a predictive model of falls. One critical quantity for postural instability detection and prediction is the instantaneous stability of quiet upright stance based on motion data. However, well-established measures in the field of motor control that quantify overall postural stability using center-of-pressure (COP or center-of-mass (COM fluctuations are inadequate predictors of instantaneous stability. For this reason, 2D COP/COM virtual-time-to-contact (VTC is investigated to detect the postural stability deficits of healthy older people compared to young adults. VTC predicts the temporal safety margin to the functional stability boundary ( =  limits of the region of feasible COP or COM displacement and, therefore, provides an index of the risk of losing postural stability. The spatial directions with increased instability were also determined using quantities of VTC that have not previously been considered. Further, Lempel-Ziv-Complexity (LZC, a measure suitable for on-line monitoring of stability/instability, was applied to explore the temporal structure or complexity of VTC and the predictability of future postural instability based on previous behavior. These features were examined as a function of age, vision and different load weighting on the legs. The primary findings showed that for old adults the stability boundary was contracted and VTC reduced. Furthermore, the complexity decreased with aging and the direction with highest postural instability also changed in aging compared to the young adults. The findings reveal the sensitivity of the time dependent properties of 2D VTC to the detection of postural instability in aging, availability of visual information and postural stance and potential applicability as a

  4. The Effect of Visual Stimuli on Stability and Complexity of Postural Control

    Directory of Open Access Journals (Sweden)

    Haizhen Luo

    2018-02-01

    Full Text Available Visual input could benefit balance control or increase postural sway, and it is far from fully understanding the effect of visual stimuli on postural stability and its underlying mechanism. In this study, the effect of different visual inputs on stability and complexity of postural control was examined by analyzing the mean velocity (MV, SD, and fuzzy approximate entropy (fApEn of the center of pressure (COP signal during quiet upright standing. We designed five visual exposure conditions: eyes-closed, eyes-open (EO, and three virtual reality (VR scenes (VR1–VR3. The VR scenes were a limited field view of an optokinetic drum rotating around yaw (VR1, pitch (VR2, and roll (VR3 axes, respectively. Sixteen healthy subjects were involved in the experiment, and their COP trajectories were assessed from the force plate data. MV, SD, and fApEn of the COP in anterior–posterior (AP, medial–lateral (ML directions were calculated. Two-way analysis of variance with repeated measures was conducted to test the statistical significance. We found that all the three parameters obtained the lowest values in the EO condition, and highest in the VR3 condition. We also found that the active neuromuscular intervention, indicated by fApEn, in response to changing the visual exposure conditions were more adaptive in AP direction, and the stability, indicated by SD, in ML direction reflected the changes of visual scenes. MV was found to capture both instability and active neuromuscular control dynamics. It seemed that the three parameters provided compensatory information about the postural control in the immersive virtual environment.

  5. The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5.

    Directory of Open Access Journals (Sweden)

    Dan Jin

    2018-02-01

    Full Text Available The control of seed germination and seed dormancy are critical for the successful propagation of plant species, and are important agricultural traits. Seed germination is tightly controlled by the balance of gibberellin (GA and abscisic acid (ABA, and is influenced by environmental factors. The COP9 Signalosome (CSN is a conserved multi-subunit protein complex that is best known as a regulator of the Cullin-RING family of ubiquitin E3 ligases (CRLs. Multiple viable mutants of the CSN showed poor germination, except for csn5b-1. Detailed analyses showed that csn1-10 has a stronger seed dormancy, while csn5a-1 mutants exhibit retarded seed germination in addition to hyperdormancy. Both csn5a-1 and csn1-10 plants show defects in the timely removal of the germination inhibitors: RGL2, a repressor of GA signaling, and ABI5, an effector of ABA responses. We provide genetic evidence to demonstrate that the germination phenotype of csn1-10 is caused by over-accumulation of RGL2, a substrate of the SCF (CRL1 ubiquitin E3 ligase, while the csn5a-1 phenotype is caused by over-accumulation of RGL2 as well as ABI5. The genetic data are consistent with the hypothesis that CSN5A regulates ABI5 by a mechanism that may not involve CSN1. Transcriptome analyses suggest that CSN1 has a more prominent role than CSN5A during seed maturation, but CSN5A plays a more important role than CSN1 during seed germination, further supporting the functional distinction of these two CSN genes. Our study delineates the molecular targets of the CSN complex in seed germination, and reveals that CSN5 has additional functions in regulating ABI5, thus the ABA signaling pathway.

  6. Prognostic Significance of Combination of Preoperative Platelet Count and Neutrophil-Lymphocyte Ratio (COP-NLR in Patients with Non-Small Cell Lung Cancer: Based on a Large Cohort Study.

    Directory of Open Access Journals (Sweden)

    Hua Zhang

    Full Text Available The aim of this study was to investigate the prognostic significance of the combination of the preoperative platelet count and neutrophil-lymphocyte ratio (COP-NLR for predicting postoperative survival of patients undergoing complete resection for non-small cell lung cancer (NSCLC.The preoperative COP-NLR was calculated on the basis of data obtained.Patients with both an increased platelet count (>30.0 × 104 mm(-3 and an elevated NLR (>2.3 were assigned a score of 2, and patients with one or neither were assigned as a score of 1 or 0, respectively.A total of 1238 NSCLC patients were enrolled in this analysis. Multivariate analysis using the 15 clinicolaboratory variables selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for DFS (HR: 1.834, 95%CI: 1.536 to 2.200, P<0.001 and OS (HR: 1.810, 95%CI: 1.587 to 2.056, P<0.001. In sub-analyses by tumor stage (I, II, IIIA, a significant association was found between DFS and OS and level of COP-NLR in each subgroup (P<0.001, P=0.002, P<0.001 for DFS, respectively; P<0.001, P=0.001, P<0.001 for OS. When the subgroup of patients with high-risk COP-NLR (score of 2 was analyzed, no benefit of adjuvant chemotherapy could be found (P=0.237 for DFS and P=0.165 for OS.The preoperative COP-NLR is able to predict the prognosis of patients with NSCLC and divide these patients into three independent groups before surgery. Our results also demonstrate that high-risk patients based on the COP-NLR do not benefit from adjuvant chemotherapy. Independent validation of our findings is warranted.

  7. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  8. ICE Online Detainee Locator System

    Data.gov (United States)

    Department of Homeland Security — The Online Detainee Locator datasets provide the location of a detainee who is currently in ICE custody, or who was release from ICE custody for any reason with the...

  9. OLBS: Offline location based services

    OpenAIRE

    Coelho, P; Ana Aguiar; João Correia Lopes

    2011-01-01

    Most existing location-based services rely on ubiquitous connectivity to deliver location-based contents to the users. However, connectivity is not available anywhere at anytime even in urban centres. Underground, indoors, remote areas, and foreign countries are examples situations where users commonly do not have guaranteed connectivity but could profit from location-based contents. In this work, we propose an open platform for publishing, distributing and maintaining location-based contents...

  10. LOCAT - A Data Retrieval Program.

    Science.gov (United States)

    1984-12-01

    onoitode of scified location - P C RADIUS - maximum distance between specified location and C file locationsC . ’ CONNON /LOCN/ LOCLAT, LOCLNG, RADIUS...rrr’, ,r:.- r -’ - r- rJ Z. . . , . -.-. - - - - - - -- , -• .. . . FILMED 8-85 DTIC .-. ... , ,- . . . . ...: .--. :,.:. ..-..-- ,-, .-..-...

  11. Genetic screening of spinal muscular atrophy using a real-time modified COP-PCR technique with dried blood-spot DNA.

    Science.gov (United States)

    Ar Rochmah, Mawaddah; Harahap, Nur Imma Fatimah; Niba, Emma Tabe Eko; Nakanishi, Kenta; Awano, Hiroyuki; Morioka, Ichiro; Iijima, Kazumoto; Saito, Toshio; Saito, Kayoko; Lai, Poh San; Takeshima, Yasuhiro; Takeuchi, Atsuko; Bouike, Yoshihiro; Okamoto, Maya; Nishio, Hisahide; Shinohara, Masakazu

    2017-10-01

    Spinal muscular atrophy (SMA) is a common neuromuscular disorder caused by mutations in SMN1. More than 95% of SMA patients carry homozygous SMN1 deletion. SMA is the leading genetic cause of infant death, and has been considered an incurable disease. However, a recent clinical trial with an antisense oligonucleotide drug has shown encouraging clinical efficacy. Thus, early and accurate detection of SMN1 deletion may improve prognosis of many infantile SMA patients. A total of 88 DNA samples (37 SMA patients, 12 carriers and 39 controls) from dried blood spots (DBS) on filter paper were analyzed. All participants had previously been screened for SMN genes by PCR restriction fragment length polymorphism (PCR-RFLP) using DNA extracted from freshly collected blood. DNA was extracted from DBS that had been stored at room temperature (20-25°C) for 1week to 5years. To ensure sufficient quality and quantity of DNA samples, target sequences were pre-amplified by conventional PCR. Real-time modified competitive oligonucleotide priming-PCR (mCOP-PCR) with the pre-amplified PCR products was performed for the gene-specific amplification of SMN1 and SMN2 exon 7. Compared with PCR-RFLP using DNA from freshly collected blood, results from real-time mCOP-PCR using DBS-DNA for detection of SMN1 exon 7 deletion showed a sensitivity of 1.00 (CI [0.87, 1.00])] and specificity of 1.00 (CI [0.90, 1.00]), respectively. We combined DNA extraction from DBS on filter paper, pre-amplification of target DNA, and real-time mCOP-PCR to specifically detect SMN1 and SMN2 genes, thereby establishing a rapid, accurate, and high-throughput system for detecting SMN1-deletion with practical applications for newborn screening. Copyright © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  12. Location theory a unified approach

    CERN Document Server

    Nickel, Stefan

    2006-01-01

    Although modern location theory is now more than 90 years old, the focus of researchers in this area has been mainly problem oriented. However, a common theory, which keeps the essential characteristics of classical location models, is still missing.This monograph addresses this issue. A flexible location problem called the Ordered Median Problem (OMP) is introduced. For all three main subareas of location theory (continuous, network and discrete location) structural properties of the OMP are presented and solution approaches provided. Numerous illustrations and examples help the reader to bec

  13. Cops for Hire

    DEFF Research Database (Denmark)

    Tepe, Markus; Vanhuysse, Pieter

    2013-01-01

    especially attractive for conservative parties. Testing these electioneering and partisanship hypotheses in the German states between 1992 and 2010, we find that socio-economic variables such as population density strongly determine police employment. But incumbents also hire more police officers before...

  14. COP 1990-1991

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Compared nekton densities among 5 natural and 10 created salt marsh sites to test whether these marsh types were functionally equivalent. Created marshes ranged from...

  15. Before Stabilization

    DEFF Research Database (Denmark)

    Plesner, Ursula; Horst, Maja

    2013-01-01

    of the communication about innovations in information and communication technology (ICT), and to contribute to an understanding of how different visions promise particular future configurations of workflows, communication processes, politics, economic models and social relations. Hereby, the paper adds...... to the literature on the relationship between ICTs and organizing, but with a distinct focus on innovation communication and distributed innovation processes taking place before ICTs are stabilized, issues which cannot be captured by studies of diffusion and adaptation of new ICTs within single organizations....

  16. Univariate and Bivariate Empirical Mode Decomposition for Postural Stability Analysis

    Directory of Open Access Journals (Sweden)

    Jacques Duchêne

    2008-05-01

    Full Text Available The aim of this paper was to compare empirical mode decomposition (EMD and two new extended methods of  EMD named complex empirical mode decomposition (complex-EMD and bivariate empirical mode decomposition (bivariate-EMD. All methods were used to analyze stabilogram center of pressure (COP time series. The two new methods are suitable to be applied to complex time series to extract complex intrinsic mode functions (IMFs before the Hilbert transform is subsequently applied on the IMFs. The trace of the analytic IMF in the complex plane has a circular form, with each IMF having its own rotation frequency. The area of the circle and the average rotation frequency of IMFs represent efficient indicators of the postural stability status of subjects. Experimental results show the effectiveness of these indicators to identify differences in standing posture between groups.

  17. What Really Happened in The Hague? Report on the COP 6. Part I. 13 - 25 November 2000, The Hague, The Netherlands

    International Nuclear Information System (INIS)

    Buchner, B.K.

    2001-06-01

    This paper investigates the occurrences at the Sixth Conference of the Parties (CoP) to the 1992 United Nations Framework Convention on Climate Change (UNFCCC) which took place in The Hague, Netherlands, from 13-25 November of 2000. Since the conference did not reach an agreement there exists a broad interest in knowing what really happened during the negotiations. The aim of the analysis is to give greater insight to reasons of the climate talks' failure and to progress made during the negotiations. Following the discussions of the issues surrounding the talks in The Hague, the paper will also look forward as to possible solutions and ideas for an eventual agreement

  18. La vagina dentada: una interpretación de la Estela 25 de Izapa y las guacamayas del juego de pelota de Copán

    OpenAIRE

    Chinchilla Mazariegos, Oswaldo

    2010-01-01

    Las aves representadas en la Estela 25 de Izapa y el juego de pelota de Copán forman el punto de partida para un examen del tema mitológico de la vagina dentada en Mesoamérica, y sus expresiones en el arte y la narrativa. Un amplio conjunto de narraciones mitológicas recopiladas en México y Guatemala sirve como base para un examen de la historia de Siete Guacamayo en el Popol Vuh, la cual se interpreta como una variante de un mito ampliamente difundido, relacionado con el origen del Sol y la ...

  19. La COP21 y el Acuerdo de París: una clase magistral en diplomacia en busca de mayor ambición

    OpenAIRE

    Lázaro, Lara

    2016-01-01

    Muchos de los elementos clave que resultaron en el Acuerdo de Copenhague han evolucionado en los últimos seis años. Una mayor evidencia científica, un mayor desarrollo en el análisis económico relativo a las consecuencias del cambio climático, los avances tecnológicos, el desarrollo del sector energético renovable y las transformaciones en la gobernanza climática han posibilitado la adopción del Acuerdo de Paris. El presente artículo analiza algunos de estos factores, los resultados de la COP...

  20. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  1. Tropical cyclones in a stabilized 1.5 and 2 degree warmer world.

    Science.gov (United States)

    Wehner, M. F.; Stone, D. A.; Loring, B.; Krishnan, H.

    2017-12-01

    We present an ensemble of very high resolution global climate model simulations of a stabilized 1.5oC and 2oC warmer climate as envisioned by the Paris COP21 agreement. The resolution of this global climate model (25km) permits simulated tropical cyclones up to Category Five on the Saffir-Simpson scale Projected changes in tropical cyclones are significant. Tropical cyclones in the two stabilization scenarios are less frequent but more intense than in simulations of the present. Output data from these simulations is freely available to all interested parties and should prove a useful resource to those interested in studying the impacts of stabilized global warming.

  2. Location, Location, Location: Does Place Provide the Opportunity for Differentiation for Universities?

    Science.gov (United States)

    Winter, Emma; Thompson-Whiteside, Helen

    2017-01-01

    The fiercely competitive HE market has led HEIs to invest significant resources in building a distinct identity. An HEI's location forms an inherent part of its identity and the uniqueness of location offers an opportunity to differentiate. However there has been limited examination of how location is used by HEIs and little consideration of how…

  3. Location Systems An Introduction to the Technology Behind Location Awareness

    CERN Document Server

    LaMarca, Anthony

    2008-01-01

    Advances in electronic location technology and the coming of age of mobile computing have opened the door for location-aware applications to permeate all aspects of everyday life. Location is at the core of a large number of high-value applications ranging from the life-and-death context of emergency response to serendipitous social meet-ups. For example, the market for GPS products and services alone is expected to grow to US200 billion by 2015. Unfortunately, there is no single location technology that is good for every situation and exhibits high accuracy, low cost, and universal coverage.

  4. Principal Stability and the Rural Divide

    Science.gov (United States)

    Pendola, Andrew; Fuller, Edward J.

    2018-01-01

    This article examines the unique features of the rural school context and how these features are associated with the stability of principals in these schools. Given the small but growing literature on the characteristics of rural principals, this study presents an exploratory analysis of principal stability across schools located in different…

  5. RLA room 20 cleanout and stabilization

    International Nuclear Information System (INIS)

    Ham, J.E.

    1997-01-01

    This engineering report documents the decontamination and stabilization of the Rupture Loop Annex located in room 20 of the 309 building's Plutonium Recycle Test Reactor. Low level, mixed, and recyclable waste was removed from the room. Smearable contamination was removed and/or fixed in place with paint. The RLA was cleaned out and stabilized to meet the Environmental Restoration Contractor's turnover criteria

  6. Report on the survey in fiscal 1998. Evaluation by Industry on the result of COP3 and the future activities (Britain); 1998 nendo chosa hokokusho. COP3 no kekka ni taisuru sangyokai no hyoka oyobi kongo no taio ni tsuite (Eikoku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    A survey was carried out to identify the evaluation by British Industry on COP3 and the nation's future activities. In Britain, the gas emission level in 2000 is estimated to achieve sufficiently the initial target as the level is lower by 4 to 8% than that in 1990. This is largely attributable to substitution of coal by natural gas. At the Kyoto Conference, the European Union agreed with its target to reduce the emission of greenhouse effect gas over the period 2008-2012 to 8% below its 1990 level. Britain agreed to share its reduction rate at 12.5%. The Labour Party had set an election pledge since before the general election to reduce carbon oxide emission by 20% (against the 1990 level) by 2010, and the Prime Minister Tony Blair has also confirmed his commitment to this target. The policy making work to achieve the COP3 target has begun in 1998 when the UK Climate Change Program (consultation paper) was issued, and will continue until February 1999. The Advisory Committee of Business and Environment representing British Industry has already published their advice on how to achieve Britain's COP3 objective, which are considered by the government in the above mentioned paper. (NEDO)

  7. Location-based prospective memory.

    Science.gov (United States)

    O'Rear, Andrea E; Radvansky, Gabriel A

    2018-02-01

    This study explores location-based prospective memory. People often have to remember to do things when in a particular location, such as buying tissues the next time they are in the supermarket. For event cognition theory, location is important for structuring events. However, because event cognition has not been used to examine prospective memory, the question remains of how multiple events will influence prospective memory performance. In our experiments, people delivered messages from store to store in a virtual shopping mall as an ongoing task. The prospective tasks were to do certain activities in certain stores. For Experiment 1, each trial involved one prospective memory task to be done in a single location at one of three delays. The virtual environment and location cues were effective for prospective memory, and performance was unaffected by delay. For Experiment 2, each trial involved two prospective memory tasks, given in either one or two instruction locations, and to be done in either one or two store locations. There was improved performance when people received instructions from two locations and did both tasks in one location relative to other combinations. This demonstrates that location-based event structure influences how well people perform on prospective memory tasks.

  8. Identification of the period of stability in a balance test after stepping up using a simplified cumulative sum.

    Science.gov (United States)

    Safieddine, Doha; Chkeir, Aly; Herlem, Cyrille; Bera, Delphine; Collart, Michèle; Novella, Jean-Luc; Dramé, Moustapha; Hewson, David J; Duchêne, Jacques

    2017-11-01

    Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static. In the present study, a method is presented to detect the stabilization period after a subject has stepped onto the BQT. Four different phases of the test are identified (stepping-on, stabilization, balancing, stepping-off), ensuring that subjects are static when parameters from the balancing phase are calculated. The method, based on a simplified cumulative sum (CUSUM) algorithm, could detect the change between unstable and stable stance. The time taken to stabilize significantly affected the static balance variables of surface area and trajectory velocity, and was also related to Timed-up-and-Go performance. Such a finding suggests that the time to stabilize could be a worthwhile parameter to explore as a potential indicator of balance problems and fall risk in older people. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

  9. Design of a TDOA location engine and development of a location system based on chirp spread spectrum.

    Science.gov (United States)

    Wang, Rui-Rong; Yu, Xiao-Qing; Zheng, Shu-Wang; Ye, Yang

    2016-01-01

    Location based services (LBS) provided by wireless sensor networks have garnered a great deal of attention from researchers and developers in recent years. Chirp spread spectrum (CSS) signaling formatting with time difference of arrival (TDOA) ranging technology is an effective LBS technique in regards to positioning accuracy, cost, and power consumption. The design and implementation of the location engine and location management based on TDOA location algorithms were the focus of this study; as the core of the system, the location engine was designed as a series of location algorithms and smoothing algorithms. To enhance the location accuracy, a Kalman filter algorithm and moving weighted average technique were respectively applied to smooth the TDOA range measurements and location results, which are calculated by the cooperation of a Kalman TDOA algorithm and a Taylor TDOA algorithm. The location management server, the information center of the system, was designed with Data Server and Mclient. To evaluate the performance of the location algorithms and the stability of the system software, we used a Nanotron nanoLOC Development Kit 3.0 to conduct indoor and outdoor location experiments. The results indicated that the location system runs stably with high accuracy at absolute error below 0.6 m.

  10. Quarter Dates Location(s) Purpose Transportation and Travel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    Dates. Location(s). Purpose. Transportation and Travel. Accommodation,. Meals and Other. Hospitality. Total. Expenses. Quarter 1. May 15. Ottawa, ON. Meetings. May 20 to 21. Washington DC. Conference. 11,364.93. 3,274.71. 53.50. 14,693.14. May 5 to June 5. Kenya and England. Meetings. June 18 to 21. Winnipeg, MB.

  11. Location Based Services and Applications

    OpenAIRE

    Elenis Gorrita Michel; Rónier Sierra Dávila; Samuel Montejo Sánchez

    2012-01-01

    Location Based Services (LBS) continue to grow in popularity, effectiveness and reliability, to the extent that applications are designed and implemented taking into account the facilities of the user location information. In this work, some of the main applications are addressed, in order to make an assessment of the current importance of the LBS, as a branch of technology in full swing. In addition, the main techniques for location estimation are studied, essential information to the LBS. B...

  12. Evaluation of Steam Generator Level behavior for Determination of Turbine Runback rate on COPs trip for Yonggwang 1 and 2 Power Uprating Units

    International Nuclear Information System (INIS)

    Lee, Kyung Jin; Hwang, Su Hyun; Yoo, Tae Geun; Chung, Soon Il; An, Byung Chang; Park, Jung Gu

    2010-01-01

    4.5% power uprate project has been progressing for the first time in Yonggwang 1 and 2(YGN1 and 2). Reviews for design change due to the power uprate were accomplished. Steam generator level behavior was one of the most important parameters because it could be cause of reactor trip or turbine trip. As the results of the reviews, YGN1 and 2 had to reassess it for change of turbine runback rate when turbine runback occurs due to the condensate operating pumps (COP) trip. This study has been carried out for evaluating the steam generator level behavior for determination of turbine runback rate on COPs trip for Yonggwang 1 and 2 Power Uprating Units. The steam generator water level evaluation program for YGN1 and 2 (SLEP-Y1) has been developed for it. The program includes models for the steam generator water level response. SLEP-Y1 is programmed with advanced continuous system simulation language (ACSL). The language has been used to simulate physical systems as a commercial tool used to evaluate system designs

  13. Location i det geopolitiske rum

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2017-01-01

    Hovedformålet med artiklen er at undersøge forholdet mellem genrehåndtering og location i The Night Manager. Genren er thrilleren i den spionudgave, der er kendt fra tidligere John Le Carré-filmatiseringer. Location passer perfekt til genren med valget af glamourøse steder, der har kunnet bruges i...

  14. Improved Dynamic Planar Point Location

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Arge, Lars; Georgiadis, Loukas

    2006-01-01

    We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time.......We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time....

  15. Evolutionary economics and industry location

    NARCIS (Netherlands)

    Boschma, R.A.; Frenken, K.

    2003-01-01

    This paper aims to provide the outlines of an evolutionary economic geography of industry location. We discuss two evolutionary explanations of industry location, that is, one that concentrates on spin-offs, and one that focuses attention on knowledge and agglomeration economies. We claim that both

  16. Locations in television drama series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    in the extra bonus material (Gray, 2010; Waade, 2013), and film tours and film apps become part of the television series’ trans-media franchise (Reijnders, 2011; Thompson, 2007). Location has so far been a practical term describing the place where the series is shot. Ellis (1992) used to see location...

  17. Locations in Television Drama Series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    2017-01-01

    This special issue is dedicated to the analysis of the increasingly significant role of location as a key element in television drama. In recent years, the popularity of serial television has progressively been tied to the expanded use of location as a central element in productions, both as sett...... mainly been considered as a practical term in film and television productions....

  18. Family ties and residential locations

    NARCIS (Netherlands)

    Mulder, C.H.; Cooke, T.J.

    2009-01-01

    In this paper, and in the Special Issue it introduces, the focus is on the role of family ties in residential location choice and, conversely, the role of residential locations in maintaining family ties. Not only do events in the nuclear family trigger residential relocations, but nearby family

  19. Uncapacitated facility location problems: contributions

    Directory of Open Access Journals (Sweden)

    Galvão Roberto Diéguez

    2004-01-01

    Full Text Available The objective of the present paper is to review my personal contributions in the field of uncapacitated facility location problems. These contributions took place throughout my academic career, from the time I was a Ph.D. student at Imperial College to the present day. They cover approximately 30 years, from 1973 to 2003; they address: algorithms developed for the p-median problem and for a general formulation of uncapacitated location problems; the study of dynamic location models; covering and hierarchical location problems; queuing-based probabilistic location models. The contributions encompass theoretical developments, computational algorithms and practical applications. All work took place in an academic environment, with the invaluable collaboration of colleagues (both in Brazil and abroad and research students at COPPE. Each section in the paper is dedicated to a topic that involves a personal contribution. Every one of them is placed within the context of the existing literature.

  20. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  1. Filament bundle location influence on coupling losses in superconducting composites

    International Nuclear Information System (INIS)

    Ito, Daisuke; Koizumi, Misao; Hamajima, Takataro; Nakane, Fumoto.

    1983-01-01

    The ac losses in multifilamentary superconducting composites with different superconducting filament bundle positions have been measured using the magnetization method in order to reveal the relation between filament bundle position and coupling losses. Loss components depending on dB/dt in a mixed matrix superconducting composite, whose filament bundle is located in a central region surrounded by an outer stabilizing copper sheath, has been compared with another superconducting composite whose stabilizing copper is located in a central region surrounded by an outer filament bundle. In both conductors, key parameters, such as filament twistpitch, wire diameter and amount of copper stabilizer, were almost the same. Applied magnetic field is 2 Tesla with 0.05-2 Tesla/sec field change rate. Experimental results indicate that coupling losses between filaments in the composite with the filament bundle located in the central region is smaller than the composite with the filament bundle located in the outer region. A similar conclusion was reached theoretically by B. Truck. Coupling loss values obtained by the experiment show good agreement with calculated values with the equations proposed by B. Truck. It is also pointed out that a copper stabilizer, divided by the CuNi barrier into small regions, like a honeycomb, causes anomalous increasing in the copper resistivity due to Ni diffusion during heat treatment. (author)

  2. Spatial Working Memory Capacity Predicts Bias in Estimates of Location

    Science.gov (United States)

    Crawford, L. Elizabeth; Landy, David; Salthouse, Timothy A.

    2016-01-01

    Spatial memory research has attributed systematic bias in location estimates to a combination of a noisy memory trace with a prior structure that people impose on the space. Little is known about intraindividual stability and interindividual variation in these patterns of bias. In the current work, we align recent empirical and theoretical work on…

  3. Locating room air-conditioners at floor level for energy saving in residential buildings

    International Nuclear Information System (INIS)

    Gao, C.F.; Lee, W.L.; Chen Hua

    2009-01-01

    Residential air-conditioning becomes a common feature in our daily life. They are typically installed at high level known as ceiling-based system (CAC). With the increasing use of floor-based air-conditioning system in commercial buildings for energy saving, it is proposed in this study to locate a top discharge/front return air-conditioner at floor level to resemble a floor-based air-conditioning system (FAC) to curb energy use in residential buildings. Given the concerns about draught discomfort and thermal stratification associated with floor-based air-conditioning systems, the objective of this study is to evaluate the air distribution performance and to quantify the possible energy benefits. Bedroom was chosen as a sensitive case for detailed air distribution performance evaluation. Experimental study, CFD simulations and energy simulations were conducted in achieving the specific objectives. CAC and FAC were installed in a bedroom-like environmental chamber for experimental study at different indoor and outdoor conditions. The air velocities and temperatures at various positions and levels inside the chamber were measured to determine the air distribution performance indices (ADPI) and airflow draft risk (DR). The cooling output, power consumption and coefficient of performance (COP) of the two units were measured and calculated for comparison. The experimental results show that ADPI of CAC and FAC are 92.3% and 84.6%, respectively. COP of FAC is 8.11% higher than CAC, and the corresponding DR are comparable. The experimental results were used to validate the CFD simulations as well as providing actual performance data for predicting the energy use of applying CAC and FAC in a case-study building. CFD simulations and draught assessment confirmed that there is no potential draught discomfort and thermal stratification associated with the use of FAC. Energy simulations predicted that the associated energy saving is 6.9%. Wider use of FAC in residential

  4. Locating room air-conditioners at floor level for energy saving in residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    Gao, C.F.; Lee, Hua; Chen, W.L. [Department of Building Services Engineering, Hong Kong Polytechnic University, Hung Hom (China)

    2009-08-15

    Residential air-conditioning becomes a common feature in our daily life. They are typically installed at high level known as ceiling-based system (CAC). With the increasing use of floor-based air-conditioning system in commercial buildings for energy saving, it is proposed in this study to locate a top discharge/front return air-conditioner at floor level to resemble a floor-based air-conditioning system (FAC) to curb energy use in residential buildings. Given the concerns about draught discomfort and thermal stratification associated with floor-based air-conditioning systems, the objective of this study is to evaluate the air distribution performance and to quantify the possible energy benefits. Bedroom was chosen as a sensitive case for detailed air distribution performance evaluation. Experimental study, CFD simulations and energy simulations were conducted in achieving the specific objectives. CAC and FAC were installed in a bedroom-like environmental chamber for experimental study at different indoor and outdoor conditions. The air velocities and temperatures at various positions and levels inside the chamber were measured to determine the air distribution performance indices (ADPI) and airflow draft risk (DR). The cooling output, power consumption and coefficient of performance (COP) of the two units were measured and calculated for comparison. The experimental results show that ADPI of CAC and FAC are 92.3% and 84.6%, respectively. COP of FAC is 8.11% higher than CAC, and the corresponding DR are comparable. The experimental results were used to validate the CFD simulations as well as providing actual performance data for predicting the energy use of applying CAC and FAC in a case-study building. CFD simulations and draught assessment confirmed that there is no potential draught discomfort and thermal stratification associated with the use of FAC. Energy simulations predicted that the associated energy saving is 6.9%. Wider use of FAC in residential

  5. Postural stability in the elderly during sensory perturbations and dual tasking: the influence of refractive blur.

    Science.gov (United States)

    Anand, Vijay; Buckley, John G; Scally, Andy; Elliott, David B

    2003-07-01

    To determine the influence of refractive blur on postural stability during somatosensory and vestibular system perturbation and dual tasking. Fifteen healthy, elderly subjects (mean age, 71 +/- 5 years), who had no history of falls and had normal vision, were recruited. Postural stability during standing was assessed using a force platform, and was determined as the root mean square (RMS) of the center of pressure (COP) signal in the anterior-posterior (A-P) and medial-lateral directions collected over a 30-second period. Data were collected under normal standing conditions and with somatosensory and vestibular system perturbations. Measurements were repeated with an additional physical and/or cognitive task. Postural stability was measured under conditions of binocular refractive blur of 0, 1, 2, 4, and 8 D and with eyes closed. The data were analyzed with a population-averaged linear model. The greatest increases in postural instability were due to disruptions of the somatosensory and vestibular systems. Increasing refractive blur caused increasing postural instability, and its effect was greater when the input from the other sensory systems was disrupted. Performing an additional cognitive and physical task increased A-P RMS COP further. All these detrimental effects on postural stability were cumulative. The findings highlight the multifactorial nature of postural stability and indicate why the elderly, many of whom have poor vision and musculoskeletal and central nervous system degeneration, are at greater risk of falling. The findings also highlight that standing instability in both normal and perturbed conditions was significantly increased with refractive blur. Correcting visual impairment caused by uncorrected refractive error could be a useful intervention strategy to help prevent falls and fall-related injuries in the elderly.

  6. VT School Locations - K-12

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) FacilitiesSchools_PTSCHOOL is designed to provide point locations of every Vermont School along with the established school ID (PSID) for...

  7. Hull properties in location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    Some properties of the solution set for single and multifacility continuous location problems with lp distances are given. A set reduction algorithm is developed for problems in k-dimensional space having rectangular distances....

  8. WHERE2 Location Aided Communications

    DEFF Research Database (Denmark)

    Dammann, Armin; Agapiou, George; Brunel, Loïc

    2013-01-01

    This paper presents an overview of preliminary results of investigations within the WHERE2 Project on identifying promising avenues for location aided enhancements to wireless communication systems. The wide ranging contributions are organized according to the following targeted systems: cellular...

  9. Water Well Locations - Conservation Wells

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The conservation well layer identifies the permitted surface location of oil and gas conservation wells that have not been plugged. These include active, regulatory...

  10. Allegheny County Blazed Trails Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Shows the location of blazed trails in all Allegheny County parks. This is the same data used in the Allegheny County Parks Trails Mobile App, available for Apple...

  11. CBP List of Preclearance Locations

    Data.gov (United States)

    Department of Homeland Security — CBP Preclearance provides for the U.S. border inspection and clearance of commercial air passengers and their goods at (15) locations in (6) foreign countries. CBP...

  12. Allegheny County WIC Vendor Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of Women, Infants, and Children (WIC) program vendors. If viewing this description on the Western Pennsylvania Regional Data...

  13. Análise do COP e sentido de posição em jogadores universitários de futebol com e sem instabilidade de tornozelo

    Directory of Open Access Journals (Sweden)

    Antônio Francisco de Almeida Neto

    Full Text Available Resumo O objetivo do estudo foi comparar o comportamento do COP e do sentido de posição articular passivo em indivíduos com e sem instabilidade de tornozelo, e correlacionar as variáveis de COP e sentido de posição articular passivo. Participaram 20 indivíduos, divididos em dois grupos: grupo estável (GE e grupo instável (GI. A avaliação do COP foi feita com o teste de apoio unipodal, com olhos abertos e fechados sobre uma plataforma de força. O teste de reposicionamento articular passivo foi realizado com os olhos vendados. O tornozelo foi posicionado em um ângulo alvo (10° e 20° e o dinamômetro movia passivamente o tornozelo, então os participantes eram instruídos a apertar o botão para parar o movimento quando sentissem que o tornozelo estava no ângulo alvo, obtendo assim o erro angular absoluto (EAA. Foram obtidas as variáveis: deslocamento total (DT; desvio padrão ântero-posterior (DPap e médio-lateral (DPml; velocidade média total (VMT; velocidade média ântero-posterior (VMap e médio-lateral (VMml. A comparação entre dados que apresentaram distribuição normal foi feita com o teste t de Student, enquanto que para DT e DPml foi utilizado o teste de Mann-Whitney. Da mesma forma, foram usados os testes de Pearson e Spearman para correlacionar as variáveis. Foi adotado α < 0,05. Houve diferença entre EAA-10° (p < 0,05. Foram encontradas fortes correlações entre: EAA-10° e VMT (p < 0,01 r = −0,867; EAA-10° e VMap (p < 0,01 r = −0,854; EAA-10° e VMml (p < 0,01 r = −0,771, na condição olhos abertos, e EAA-10° e DT (p < 0,05 r = −0,666; EAA-10° e DPap (p < 0,05 r = −0,685 e EAA-10° e VMml (p < 0,05 r = −0,766 na condição olhos fechados. Entorses de tornozelo prejudicam o sentido de posição, sem afetar o equilíbrio.

  14. Cliffs versus plains: Can ROSINA/COPS and OSIRIS data of comet 67P/Churyumov-Gerasimenko in autumn 2014 constrain inhomogeneous outgassing?

    Science.gov (United States)

    Marschall, R.; Mottola, S.; Su, C. C.; Liao, Y.; Rubin, M.; Wu, J. S.; Thomas, N.; Altwegg, K.; Sierks, H.; Ip, W.-H.; Keller, H. U.; Knollenberg, J.; Kührt, E.; Lai, I. L.; Skorov, Y.; Jorda, L.; Preusker, F.; Scholten, F.; Vincent, J.-B.; Osiris Team; Rosina Team

    2017-09-01

    Context. This paper describes the modelling of gas and dust data acquired in the period August to October 2014 from the European Space Agency's Rosetta spacecraft when it was in close proximity to the nucleus of comet 67P/Churyumov-Gerasimenko. Aims: With our 3D gas and dust comae models this work attempts to test the hypothesis that cliff activity on comet 67P/Churyumov-Gerasimenko can solely account for the local gas density data observed by the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) and the dust brightnesses seen by the Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) in the considered time span. Methods: The model uses a previously developed shape model of the nucleus. From this, the water sublimation rates and gas temperatures at the surface are computed. The gas expansion is modelled with a 3D Direct Simulation Monte Carlo algorithm. A dust drag algorithm is then used to compute dust volume number densities in the coma, which are then converted to brightnesses using Mie theory and a line-of-sight integration. Furthermore we have studied the impact of topographic re-radiation on the models. Results: We show that gas activity from only cliff areas produces a fit to the ROSINA/COPS data that is as statistically good as a purely insolation-driven model. In contrast, pure cliff activity does not reproduce the dust brightness observed by OSIRIS and can thus be ruled out. On the other hand, gas activity from the Hapi region in addition to cliff activity produces a statistically better fit to the ROSINA/COPS data than purely insolation-driven outgassing and also fits the OSIRIS observations rather well. We found that topographic re-radiation does not contribute significantly to the sublimation behaviour of H2O but plays an important role in how the gas flux interacts with the irregular shape of the nucleus. Conclusions: We demonstrate that fits to the observations are non-unique. We can conclude however that gas and dust

  15. Improvement of the oxidation stability of cobalt nanoparticles

    Directory of Open Access Journals (Sweden)

    Celin Dobbrow

    2012-01-01

    Full Text Available In order to enhance the resistance of cobalt nanoparticles to oxidation in air, the impact of different stabilization strategies on the isothermal oxidation of particle dispersions and powders was kinetically investigated and compared to as-prepared particle preparations. A post-synthesis treatment with different alcohols was employed, and we also investigate the influence of two different polymer shells on the oxidation process. We found a parabolic decrease of the magnetization for all particle charges, indicating that the process is dominated by a diffusion of oxygen to the cobalt core and a radial growth of the oxide layer from the particle surface to the core. A significant deceleration of the oxidation process was observed for all alcohol-passivated particle preparations, and this resulted finally in a stagnation effect. The stabilizing effect increases in the sequence Co@OA/MeOH < Co@OA/EtOH < Co@OA/iPrOH. For polymer-coated particle preparations Co@PCL and Co@PS, the deceleration was even more pronounced. The results demonstrate that cobalt nanoparticles can effectively be protected against oxidation in order to improve their mid- to longterm stability.

  16. Haptic Cues for Balance: Use of a Cane Provides Immediate Body Stabilization

    Directory of Open Access Journals (Sweden)

    Stefania Sozzi

    2017-12-01

    Full Text Available Haptic cues are important for balance. Knowledge of the temporal features of their effect may be crucial for the design of neural prostheses. Touching a stable surface with a fingertip reduces body sway in standing subjects eyes closed (EC, and removal of haptic cue reinstates a large sway pattern. Changes in sway occur rapidly on changing haptic conditions. Here, we describe the effects and time-course of stabilization produced by a haptic cue derived from a walking cane. We intended to confirm that cane use reduces body sway, to evaluate the effect of vision on stabilization by a cane, and to estimate the delay of the changes in body sway after addition and withdrawal of haptic input. Seventeen healthy young subjects stood in tandem position on a force platform, with eyes closed or open (EO. They gently lowered the cane onto and lifted it from a second force platform. Sixty trials per direction of haptic shift (Touch → NoTouch, T-NT; NoTouch → Touch, NT-T and visual condition (EC-EO were acquired. Traces of Center of foot Pressure (CoP and the force exerted by cane were filtered, rectified, and averaged. The position in space of a reflective marker positioned on the cane tip was also acquired by an optoelectronic device. Cross-correlation (CC analysis was performed between traces of cane tip and CoP displacement. Latencies of changes in CoP oscillation in the frontal plane EC following the T-NT and NT-T haptic shift were statistically estimated. The CoP oscillations were larger in EC than EO under both T and NT (p < 0.001 and larger during NT than T conditions (p < 0.001. Haptic-induced effect under EC (Romberg quotient NT/T ~ 1.2 was less effective than that of vision under NT condition (EC/EO ~ 1.5 (p < 0.001. With EO cane had little effect. Cane displacement lagged CoP displacement under both EC and EO. Latencies to changes in CoP oscillations were longer after addition (NT-T, about 1.6 s than withdrawal (T-NT, about 0.9 s of haptic

  17. A Calculus of Located Entities

    Directory of Open Access Journals (Sweden)

    Adriana Compagnoni

    2014-03-01

    Full Text Available We define BioScapeL, a stochastic pi-calculus in 3D-space. A novel aspect of BioScapeL is that entities have programmable locations. The programmer can specify a particular location where to place an entity, or a location relative to the current location of the entity. The motivation for the extension comes from the need to describe the evolution of populations of biochemical species in space, while keeping a sufficiently high level description, so that phenomena like diffusion, collision, and confinement can remain part of the semantics of the calculus. Combined with the random diffusion movement inherited from BioScape, programmable locations allow us to capture the assemblies of configurations of polymers, oligomers, and complexes such as microtubules or actin filaments. Further new aspects of BioScapeL include random translation and scaling. Random translation is instrumental in describing the location of new entities relative to the old ones. For example, when a cell secretes a hydronium ion, the ion should be placed at a given distance from the originating cell, but in a random direction. Additionally, scaling allows us to capture at a high level events such as division and growth; for example, daughter cells after mitosis have half the size of the mother cell.

  18. Secular stability of rotating stars

    International Nuclear Information System (INIS)

    Imamura, J.N.; Friedman, J.L.; Durisen, R.H.

    1984-01-01

    In this work, we calculate the secular stability limits of rotating polytropes to nonaxisymmetric perturbations of low m. We consider polytropic indices ranging from 1 to 3 and several angular momentum distributions. Results are most conveniently presented in terms of the t-parameter, defined as the ratio of the rotational kinetic energy to the absolute value of the gravitational energy of the fluid. Previous work on polytropes considered only the m = 2 mode, which is unstable for values of the t-parameter greater than 0.14 +- 0.01 for the n values n = 1.5 and 3 and the angular momentum distributions tested (see Durisen and Imamura 1981). The GRR secular stability limit of the m = 2 mode for the Maclaurin spheroids (n = O) was determined by Chandrasekhar (1970). GRR stability limits of higher m modes for the Maclaurin spheroids were located approximately by Comins (1979a,b) and more precisely by Friedman (1983)

  19. Residential Location, Job Location, and Wages: Theory and Empirics

    DEFF Research Database (Denmark)

    Vejlin, Rune Majlund

    -to-job transition without changing workplace location. However, workers making a job-to-job transition which makes the workplace location closer to the residence experiences a wage drop. Furthermore, low wage workers and workers with high transportation costs are more likely to make job-to-job transitions, but also......I develop a stylized partial on-the-job equilibrium search model which incorporate a spatial dimension. Workers reside on a circle and can move at a cost. Each point on the circle has a wage distribution. Implications about wages and job mobility are drawn from the model and tested on Danish...... matched employer-employee data. The model predictions hold true. I find that workers working farther away from their residence earn higher wages. When a worker is making a job-to-job transition where he changes workplace location he experiences a higher wage change than a worker making a job...

  20. Permian Basin location recommendation report

    International Nuclear Information System (INIS)

    1983-09-01

    Candidate study areas are screened from the Palo Duro and Dalhart Basin areas using data obtained from studies to date and criteria and specifications that consider: rock geometry; rock characteristics; human intrusion potential; surface characteristics; and environmental and socioeconomic conditions. Two preferred locations are recommended from among these areas for additional characterization to identify potential National Waste Terminal Storage (NWTS) salt repository sites. One location, in northeastern Deaf Smith County and southeastern Oldham County, is underlain by two salt units that meet the adopted screening specifications. The other location, in northcentral Swisher County, is underlain by one salt unit that meets the adopted screening specifications. Both locations have several favorable features, relative to surrounding areas, and no obviously undesirable characteristics. Both lie wholly on the Southern High Plains surface, are in relatively sparsely populated areas, contain no unique land use conflicts, and comprise large enough geographic areas to provide flexibility in site selection. Data gathered to date indicate that these locations contain salt units sufficient in thickness and in depth for the safe construction and operation of the underground facilities under consideration. 93 references, 34 figures, 6 tables

  1. Location and activity specific site-management for military locations

    NARCIS (Netherlands)

    Maring, L.; Hulst, M. van; Meuken, D.

    2009-01-01

    pace is limited in the Netherlands and military activities, that may cause nuisance or environmental hazards, should therefore be considered and evaluated during the use of military locations. The last few years TNO and Deltares have worked on a research program on environmental effects due to

  2. The influence of NDT-Bobath and PNF methods on the field support and total path length measure foot pressure (COP) in patients after stroke.

    Science.gov (United States)

    Krukowska, Jolanta; Bugajski, Marcin; Sienkiewicz, Monika; Czernicki, Jan

    In stroke patients, the NDT - (Bobath - Neurodevelopmental Treatment) and PNF (Proprioceptive Neuromuscular Facilitation) methods are used to achieve the main objective of rehabilitation, which aims at the restoration of maximum patient independence in the shortest possible period of time (especially the balance of the body). The aim of the study is to evaluate the effect of the NDT-Bobath and PNF methods on the field support and total path length measure foot pressure (COP) in patients after stroke. The study included 72 patients aged from 20 to 69 years after ischemic stroke with Hemiparesis. The patients were divided into 4 groups by a simple randomization. The criteria for this division were: the body side (right or left) affected by paresis and the applied rehabilitation methods. All the patients were applied the recommended kinesitherapeutic method (randomized), 35 therapy sessions, every day for a period of six weeks. Before initiation of therapy and after 6 weeks was measured the total area of the support and path length (COP (Center Of Pressure) measure foot pressure) using stabilometer platform - alpha. The results were statistically analyzed. After treatment studied traits decreased in all groups. The greatest improvement was obtained in groups with NDT-Bobath therapy. NDT-Bobath method for improving the balance of the body is a more effective method of treatment in comparison with of the PNF method. In stroke patients, the effectiveness of NDT-Bobath method does not depend on hand paresis. Copyright © 2016 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  3. Automatic location of disruption times in JET

    Science.gov (United States)

    Moreno, R.; Vega, J.; Murari, A.

    2014-11-01

    The loss of stability and confinement in tokamak plasmas can induce critical events known as disruptions. Disruptions produce strong electromagnetic forces and thermal loads which can damage fundamental components of the devices. Determining the disruption time is extremely important for various disruption studies: theoretical models, physics-driven models, or disruption predictors. In JET, during the experimental campaigns with the JET-C (Carbon Fiber Composite) wall, a common criterion to determine the disruption time consisted of locating the time of the thermal quench. However, with the metallic ITER-like wall (JET-ILW), this criterion is usually not valid. Several thermal quenches may occur previous to the current quench but the temperature recovers. Therefore, a new criterion has to be defined. A possibility is to use the start of the current quench as disruption time. This work describes the implementation of an automatic data processing method to estimate the disruption time according to this new definition. This automatic determination allows both reducing human efforts to locate the disruption times and standardizing the estimates (with the benefit of being less vulnerable to human errors).

  4. Lattice location of impurities in silicon Carbide

    CERN Document Server

    AUTHOR|(CDS)2085259; Correia Martins, João Guilherme

    The presence and behaviour of transition metals (TMs) in SiC has been a concern since the start of producing device-grade wafers of this wide band gap semiconductor. They are unintentionally introduced during silicon carbide (SiC) production, crystal growth and device manufacturing, which makes them difficult contaminants to avoid. Once in SiC they easily form deep levels, either when in the isolated form or when forming complexes with other defects. On the other hand, using intentional TM doping, it is possible to change the electrical, optical and magnetic properties of SiC. TMs such as chromium, manganese or iron have been considered as possible candidates for magnetic dopants in SiC, if located on silicon lattice sites. All these issues can be explored by investigating the lattice site of implanted TMs. This thesis addresses the lattice location and thermal stability of the implanted TM radioactive probes 56Mn, 59Fe, 65Ni and 111Ag in both cubic 3C- and hexagonal 6H SiC polytypes by means of emission cha...

  5. Automatic location of disruption times in JET.

    Science.gov (United States)

    Moreno, R; Vega, J; Murari, A

    2014-11-01

    The loss of stability and confinement in tokamak plasmas can induce critical events known as disruptions. Disruptions produce strong electromagnetic forces and thermal loads which can damage fundamental components of the devices. Determining the disruption time is extremely important for various disruption studies: theoretical models, physics-driven models, or disruption predictors. In JET, during the experimental campaigns with the JET-C (Carbon Fiber Composite) wall, a common criterion to determine the disruption time consisted of locating the time of the thermal quench. However, with the metallic ITER-like wall (JET-ILW), this criterion is usually not valid. Several thermal quenches may occur previous to the current quench but the temperature recovers. Therefore, a new criterion has to be defined. A possibility is to use the start of the current quench as disruption time. This work describes the implementation of an automatic data processing method to estimate the disruption time according to this new definition. This automatic determination allows both reducing human efforts to locate the disruption times and standardizing the estimates (with the benefit of being less vulnerable to human errors).

  6. Wireless Damage Location Sensing System

    Science.gov (United States)

    Woodard, Stanley E. (Inventor); Taylor, Bryant Douglas (Inventor)

    2012-01-01

    A wireless damage location sensing system uses a geometric-patterned wireless sensor that resonates in the presence of a time-varying magnetic field to generate a harmonic response that will experience a change when the sensor experiences a change in its geometric pattern. The sensing system also includes a magnetic field response recorder for wirelessly transmitting the time-varying magnetic field and for wirelessly detecting the harmonic response. The sensing system compares the actual harmonic response to a plurality of predetermined harmonic responses. Each predetermined harmonic response is associated with a severing of the sensor at a corresponding known location thereof so that a match between the actual harmonic response and one of the predetermined harmonic responses defines the known location of the severing that is associated therewith.

  7. Effect of in-season neuromuscular and proprioceptive training on postural stability in male youth basketball players

    Directory of Open Access Journals (Sweden)

    Ondra Lukáš

    2017-10-01

    Full Text Available Background: Poor balance ability is a predictor of injuries of the lower extremity. Multi-intervention proprioception preventive programs, comprising balance training, strength, plyometric, agility, running, and stretching exercises, are effective in improving balance ability and reducing the risk of lower extremity injuries in athletes.Objective: The aim of the study was to examine the effect of a 20-week in-season multi-intervention proprioceptive neuromuscular training program on postural stability in male youth basketball players.Methods: Twenty-one elite male youth basketball players were divided into an intervention group (n = 10, age 17.3 ± 1.3 years and a control group (n = 11, age 16.5 ± 1.8 years. During the in-season period (20 weeks, the intervention group followed a proprioceptive and neuromuscular training program, three times per week and 20 minutes per session. Balance was tested in a quiet unipedal stance (on both the dominant and non-dominant leg on a foam mat with eyes open, before and after a 20-week period in both groups. The mean velocities in the medial-lateral and anterior-posterior directions and the mean total velocity of the centre of pressure (COP displacement were obtained with a force platform.Results: The combined effect (pre-post test × group showed that intervention resulted in significant improvement in the mean COP velocity for both the dominant and non-dominant limb in the anterior-posterior direction (p = .013 and p < .001, respectively and in the medial-lateral direction (p = .007 and p < .001, respectively as well as in the total COP velocity (p = .009 and p < .001, respectively. Conclusions: The specific proprioceptive and neuromuscular training had a positive effect on postural stability for both the dominant and non-dominant limb in basketball players.

  8. New Location Improves Efficiency | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer The physical proximity of the SAIC-Frederick Intellectual Property (IP) Office to the NCI Technology Transfer Center (NCI-TTC) is one of the many benefits of being at the Advanced Technology Research Facility (ATRF), according to Courtney Silverthorn, Ph.D. Being in one location “has increased the effectiveness of both informal communication and

  9. Part Objects and Their Location

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann; Møller-Pedersen, Birger

    1992-01-01

    The notion of location of part objects is introduced, yielding a reference to the containing object. Combined with locally defined objects and classes (block structure), singularly defined part objects, and references to part objects, it is a powerful language mechanism for defining objects...

  10. Locating a buried magnetic dipole

    Energy Technology Data Exchange (ETDEWEB)

    Caffey, T.W.H.

    1977-01-01

    The theoretical basis and required computations for locating a buried magnetic dipole are outlined. The results are compared with measurements made with a tiltable coil lowered to a depth of 20 m in a vertical borehole within a three-layered earth. this work has application to the rescue of trapped miners. 3 figures, 1 table. (RWR)

  11. Interaction in activity location scheduling

    NARCIS (Netherlands)

    Tabak, V.; Vries, de B.; Dijkstra, J.; Jessurun, A.J.

    2006-01-01

    In this paper we discuss the interaction in activity location scheduling which is the main subject of an ongoing research project called "User Simulation of Space Utilization". The aim of this research project is to develop an overall model for the simulation of human movement and utilization of

  12. WHO Standard Acupuncture Point Locations

    Directory of Open Access Journals (Sweden)

    Sabina Lim

    2010-01-01

    Full Text Available ‘WHO Standard Acupuncture Point Locations in the Western Pacific Region (WHO Standard was released in 2008. Initially, there were 92/361 controversial acupuncture points (acupoints. Through seven informal consultations and four task force team meetings, 86 points were agreed upon among the 92 controversial acupoints, leaving 6 remaining controversial acupoints, demanding active research in the future. This will enhance the reproducibility and validity of acupuncture studies. It will also lead to a better understanding of acupuncture mechanisms in order to optimize its clinical efficacy for a range of diseases and syndromes. This book has two parts: General Guidelines for Acupuncture Point Locations and WHO Standard Acupuncture Point Locations. First of all, familiarity with the General Guidelines for Acupuncture Point Locations in this book can help the reader to understand and use the contents of this book in depth. I would like to thank all of the participating experts and scholars for this great work, who have overcome the limits of previous acupuncture references. I also appreciate the dedicated effort and harmonious leadership of Dr Choi Seung-hoon, former Regional Adviser in Traditional Medicine of Western Pacific Office, WHO.

  13. The Location of Digital Ethnography

    Directory of Open Access Journals (Sweden)

    Dana M. Walker

    2010-10-01

    Full Text Available Qualitative researchers interested in digitally-located social and cultural practices have struggled with ways in which to design studies that can account for the digital aspect of cultural practices while also taking into account that those digital practices do not exist as separate (or separable in terms of our research from other social and cultural practices. As such, one of the primary and ongoing challenges facing internet-based ethnographic research is the question of how to construct the location of a project when the sites, technologically-mediated practices, and people we study exist and flow through a wider information ecology that is neither fixed nor can easily be located as “online” or “offline.” This is as much a methodological challenge as a theoretical one. If one accepts that a rigid distinction between online and offline makes little theoretical sense, then drawing a methodological line between online and offline only reifies such a dualism. While there is a developing body of internet-related ethnographic literature which is attempting to take into account the fluid nature of our information ecology (e.g. Burrell, 2009, Leander and McKim, 2003, Hine, 2007, we continue to operate on shifting ground. This article uses the case of my own work on city-specific discussion forums in Philadelphia, Pennsylvania to highlight the complexities of locating digital ethnographic work and also argue for the necessity of accounting for both movement and placed-ness.

  14. Small Business Location and Layout.

    Science.gov (United States)

    Small Business Administration, Washington, DC.

    As an approach to teaching small-business location and layout, this publication contains material for teaching one session of a basic course. The sections of the publication are as follows: (1) The Lesson Plan--an outline of the material covered, which may be used as a teaching guide, presented in two columns: an outline of the presentation, and a…

  15. LOCATING LEAKS WITH ACOUSTIC TECHNOLOGY

    Science.gov (United States)

    Many water distribution systems in this country are almost 100 years old. About 26 percent of piping in these systems is made of unlined cast iron or steel and is in poor condition. Many methods that locate leaks in these pipes are time-consuming, costly, disruptive to operations...

  16. Competition in spatial location models

    NARCIS (Netherlands)

    Webers, H.M.

    1996-01-01

    Models of spatial competition are designed and analyzed to describe the fact that space, by its very nature, is a source of market power. This field of research, lying at the interface of game theory and economics, has attracted much interest because location problems are related to many aspects of

  17. Smart location system; Sistema de localizacao inteligente Smart Location System

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Augusto Pereira da; Antunes, Rodrigo de Castro; Azevedo, Fabio Augusto Ferreira de [PipeWay Engenharia, Rio de Janeiro, RJ (Brazil); Afonso, Orlando de Jesus Ribeiro [Instituto de Pesquisas da Marinha, Rio de Janeiro, RJ (Brazil); Matsuura, Minoru; Santa Cruz, Sergio de Freitas [TRANSPETRO - PETROBRAS Transportes, Rio de Janeiro, RJ (Brazil); Santos, Jose Alberto Costa dos; Hashiguchi, Decio Issao [GDK Engenharia (Brazil)

    2003-07-01

    This paper describes the technology used in the Intelligent Location System developed by Pipeway and includes some of the results already obtained optimizing repair time and logistic costs during the location of anomalies detected by intelligent pigs, a joint operation within the scope of the contract for Sub sea Pipeline Recovery in the Guanabara Bay with PETROBRAS/TRANSPETRO and GDK Engenharia. The system uses the ELF (Extra Low Frequency) transmission and reception technology at points near a pipe, with or without concrete coating, whose signals are recorded in the inspection tool memory to accurately establish reference points, thus preventing excessive dig work or dredging when human and operational risks tend to be high. (author)

  18. Earthquake location in island arcs

    Science.gov (United States)

    Engdahl, E.R.; Dewey, J.W.; Fujita, K.

    1982-01-01

    A comprehensive data set of selected teleseismic P-wave arrivals and local-network P- and S-wave arrivals from large earthquakes occurring at all depths within a small section of the central Aleutians is used to examine the general problem of earthquake location in island arcs. Reference hypocenters for this special data set are determined for shallow earthquakes from local-network data and for deep earthquakes from combined local and teleseismic data by joint inversion for structure and location. The high-velocity lithospheric slab beneath the central Aleutians may displace hypocenters that are located using spherically symmetric Earth models; the amount of displacement depends on the position of the earthquakes with respect to the slab and on whether local or teleseismic data are used to locate the earthquakes. Hypocenters for trench and intermediate-depth events appear to be minimally biased by the effects of slab structure on rays to teleseismic stations. However, locations of intermediate-depth events based on only local data are systematically displaced southwards, the magnitude of the displacement being proportional to depth. Shallow-focus events along the main thrust zone, although well located using only local-network data, are severely shifted northwards and deeper, with displacements as large as 50 km, by slab effects on teleseismic travel times. Hypocenters determined by a method that utilizes seismic ray tracing through a three-dimensional velocity model of the subduction zone, derived by thermal modeling, are compared to results obtained by the method of joint hypocenter determination (JHD) that formally assumes a laterally homogeneous velocity model over the source region and treats all raypath anomalies as constant station corrections to the travel-time curve. The ray-tracing method has the theoretical advantage that it accounts for variations in travel-time anomalies within a group of events distributed over a sizable region of a dipping, high

  19. Plutonium inventories for stabilization and stabilized materials

    Energy Technology Data Exchange (ETDEWEB)

    Williams, A.K.

    1996-05-01

    The objective of the breakout session was to identify characteristics of materials containing plutonium, the need to stabilize these materials for storage, and plans to accomplish the stabilization activities. All current stabilization activities are driven by the Defense Nuclear Facilities Safety Board Recommendation 94-1 (May 26, 1994) and by the recently completed Plutonium ES&H Vulnerability Assessment (DOE-EH-0415). The Implementation Plan for accomplishing stabilization of plutonium-bearing residues in response to the Recommendation and the Assessment was published by DOE on February 28, 1995. This Implementation Plan (IP) commits to stabilizing problem materials within 3 years, and stabilizing all other materials within 8 years. The IP identifies approximately 20 metric tons of plutonium requiring stabilization and/or repackaging. A further breakdown shows this material to consist of 8.5 metric tons of plutonium metal and alloys, 5.5 metric tons of plutonium as oxide, and 6 metric tons of plutonium as residues. Stabilization of the metal and oxide categories containing greater than 50 weight percent plutonium is covered by DOE Standard {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides{close_quotes} December, 1994 (DOE-STD-3013-94). This standard establishes criteria for safe storage of stabilized plutonium metals and oxides for up to 50 years. Each of the DOE sites and contractors with large plutonium inventories has either started or is preparing to start stabilization activities to meet these criteria.

  20. Trapped particle stability for the kinetic stabilizer

    Science.gov (United States)

    Berk, H. L.; Pratt, J.

    2011-08-01

    A kinetically stabilized axially symmetric tandem mirror (KSTM) uses the momentum flux of low-energy, unconfined particles that sample only the outer end-regions of the mirror plugs, where large favourable field-line curvature exists. The window of operation is determined for achieving magnetohydrodynamic (MHD) stability with tolerable energy drain from the kinetic stabilizer. Then MHD stable systems are analysed for stability of the trapped particle mode. This mode is characterized by the detachment of the central-cell plasma from the kinetic-stabilizer region without inducing field-line bending. Stability of the trapped particle mode is sensitive to the electron connection between the stabilizer and the end plug. It is found that the stability condition for the trapped particle mode is more constraining than the stability condition for the MHD mode, and it is challenging to satisfy the required power constraint. Furthermore, a severe power drain may arise from the necessary connection of low-energy electrons in the kinetic stabilizer to the central region.

  1. Research report for fiscal 1998. Industrial circles' evaluation of the outcome of COP3 and their response thereto (France); 1998 nendo chosa hokokusho. COP3 no kekka ni taisuru sangyokai no hyoka oyobi kongo no taio ni tsuite (France)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Since the CO{sub 2} emission reduction cost is high under the COP3 (Third Session of the Conference of the Parties to the United Nations Framework Convention on Climate Change) rulings, they have made it clear that they will positively resort to the flexibility mechanism. This is to reserve a room for freely selecting power generation methods other than nuclear technologies with their nuclear power plants scheduled for renovation in the neighborhood of 2010. But the industrial circles are slow in responding, failing to accept the carbon fund concept. As for measures for greenhouse gas emissions reduction, since they depend on energy saving for their success, the response specially of the transportation division will be the key. In the industrial division, success depends on a voluntary consensus among industries that consume much energy. As steps to economize the trend of people's energy consumption, an energy tax and environmental tax are scheduled to be imposed. An overall program for greenhouse gas emission reduction is being drafted by a government committee, with the outline to be made known in May 1999 for finalization in autumn the same year. A power market liberalization bill has already been prepared, and a decision will soon be made on a plan for the second phase targets. France with take part in COP5, Bonn, Germany, with a general proposal carrying what are stated above. (NEDO)

  2. It's All about Location, Location, Location: Children's Memory for the "Where'' of Personally Experienced Events

    Science.gov (United States)

    Bauer, Patricia J.; Doydum, Ayzit O.; Pathman, Thanujeni; Larkina, Marina; Guler, O. Evren; Burch, Melissa

    2012-01-01

    Episodic memory is defined as the ability to recall specific past events located in a particular time and place. Over the preschool and into the school years, there are clear developmental changes in memory for when events took place. In contrast, little is known about developmental changes in memory for where events were experienced. In the…

  3. Location, Location, Location: How Would a High-Performing Charter School Network Fare in Different States?

    Science.gov (United States)

    Lozier, Chris; Rotherham, Andrew J.

    2011-01-01

    In this paper the authors do not examine different operating strategies for charter schools or analyze the impact of their often educationally intensive models on finance. Instead, because public charter schools are funded predominantly by public dollars, they simply ask what impact location--and its associated variances in public funding and the…

  4. MICROGRIDS: THE AGRIA TEST LOCATION

    Directory of Open Access Journals (Sweden)

    Aleksandra Krkoleva

    2010-01-01

    Full Text Available The paper presents the pilot Microgrid in Macedonia, developed within the framework of the MOREMICROGRIDS (EU EP6 projecet, contract No. SES6-019864 project. This Microgrid is the first of its kind being developed in the Western Balkan region and serves as pilot site for introduction and examination of the Microgrids concept in non European Union conditions. The test network consists of a part of the low voltage grid, located on a pig farm. The main electricity source for the Microgrid is a small biogas plant, which uses the biogas produced by a waste water treatment process. The paper addresses the Microgrid design, development of test scenarios and test results from the pilot location.

  5. Location Privacy in RFID Applications

    Science.gov (United States)

    Sadeghi, Ahmad-Reza; Visconti, Ivan; Wachsmann, Christian

    RFID-enabled systems allow fully automatic wireless identification of objects and are rapidly becoming a pervasive technology with various applications. However, despite their benefits, RFID-based systems also pose challenging risks, in particular concerning user privacy. Indeed, improvident use of RFID can disclose sensitive information about users and their locations allowing detailed user profiles. Hence, it is crucial to identify and to enforce appropriate security and privacy requirements of RFID applications (that are also compliant to legislation). This chapter first discusses security and privacy requirements for RFID-enabled systems, focusing in particular on location privacy issues. Then it explores the advances in RFID applications, stressing the security and privacy shortcomings of existing proposals. Finally, it presents new promising directions for privacy-preserving RFID systems, where as a case study we focus electronic tickets (e-tickets) for public transportation.

  6. On Pure and (approximate) Strong Equilibria of Facility Location Games

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Telelis, Orestis A.

    2008-01-01

    We study social cost losses in Facility Location games, where n selfish agents install facilities over a network and connect to them, so as to forward their local demand (expressed by a non-negative weight per agent). Agents using the same facility share fairly its installation cost, but every...... agent pays individually a (weighted) connection cost to the chosen location. We study the Price of Stability (PoS) of pure Nash equilibria and the Price of Anarchy of strong equilibria (SPoA), that generalize pure equilibria by being resilient to coalitional deviations. For unweighted agents on metric...

  7. Location Estimation using Delayed Measurements

    DEFF Research Database (Denmark)

    Bak, Martin; Larsen, Thomas Dall; Nørgård, Peter Magnus

    1998-01-01

    When combining data from various sensors it is vital to acknowledge possible measurement delays. Furthermore, the sensor fusion algorithm, often a Kalman filter, should be modified in order to handle the delay. The paper examines different possibilities for handling delays and applies a new techn...... technique to a sensor fusion system for estimating the location of an autonomous guided vehicle. The system fuses encoder and vision measurements in an extended Kalman filter. Results from experiments in a real environment are reported...

  8. Akzeptanz von Location Based Services

    OpenAIRE

    Bauer, Hans H.; Haber, Tobias E.; Reichardt, Tina; Bökamp, Marten

    2006-01-01

    Die enormen Investitionen in UMTS-Lizenzen und den Aufbau einer neuen Netzinfrastruktur zwingen die Mobilfunkanbieter zur Erschließung neuer Umsatzpotenziale. Durch Entwicklung neuer mobiler Mehrwertdienste hoffen sie, die „Killerapplikation“ der 3. Mobilfunkgeneration zu finden, die ähnlich wie der Short Message Service (SMS) für GSM, zum Treiber des UMTS-Markterfolges werden kann. Nach Meinung vieler Marktbeobachter könnten Location Based Services, d.h. mobile Dienste, die ...

  9. Location, location, location: does early cancer in Barrett's esophagus have a preference?

    Science.gov (United States)

    Enestvedt, Brintha K; Lugo, Ricardo; Guarner-Argente, Carlos; Shah, Pari; Falk, Gary W; Furth, Emma; Ginsberg, Gregory G

    2013-09-01

    Early cancer (high-grade dysplasia [HGD] and intramucosal carcinoma [ImCa]) associated with Barrett's esophagus (BE) may have a circumferential spatial predilection. To describe the esophageal circumferential location of early cancer in BE. Retrospective study, single tertiary referral center. One hundred nineteen patients were referred for endoscopic eradication therapy for early cancer associated with BE. Endoscopic images and reports and pathology were reviewed. Circumferential location designation of early cancer in BE by using a clock-face orientation. One hundred nineteen of 131 patients referred for endoscopic eradication therapy had a location designation for their advanced histology (91.9%). There were a total of 57 patients (47.9%) with HGD and 62 patients (52.1%) with ImCa. There was a significantly higher rate of early cancer (HGD or ImCa) in the right hemisphere (12 to 6 o'clock location) compared with the left hemisphere (84.9% vs 15.1%, P cancer was found in the 12 to 3 o'clock quadrant (64.7%); 71.9% of HGD and 58.1% of ImCa lesions were located in the 12 to 3 o'clock quadrant. Retrospective design, single center. Early cancer associated with BE is far more commonly found in the right hemisphere of the esophagus (12 to 6 o'clock) with the highest rate in the 12 to 3 o'clock quadrant. These findings support enhanced scrutiny of the right hemisphere of the esophagus during surveillance and endoscopic treatment of patients with BE. Copyright © 2013 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  10. Location, Location: Jurisdiction & Conflicts in Transborder Contract Litigation

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    In transborder contract litigation place-based factors are often decisive, both as regards jurisdiction to adjudicate as well as the rules which determine the applicable substantive law. Relevant locations include the place where the contract was made, where the parties reside, transact business...... or own property, the place of delivery, payment or other performance etc. Using concrete case-based examples, Professor Lookofsky explains how rules of jurisdiction and contract conflicts in Europe are tied to rigidly defined, single-place-based factors. In the United States, by contrast...

  11. Modeling the Variable Heliopause Location

    Science.gov (United States)

    Hensley, Kerry

    2018-03-01

    In 2012, Voyager 1 zipped across the heliopause. Five and a half years later, Voyager 2 still hasnt followed its twin into interstellar space. Can models of the heliopause location help determine why?How Far to the Heliopause?Artists conception of the heliosphere with the important structures and boundaries labeled. [NASA/Goddard/Walt Feimer]As our solar system travels through the galaxy, the solar outflow pushes against the surrounding interstellar medium, forming a bubble called the heliosphere. The edge of this bubble, the heliopause, is the outermost boundary of our solar system, where the solar wind and the interstellar medium meet. Since the solar outflow is highly variable, the heliopause is constantly moving with the motion driven by changes inthe Sun.NASAs twin Voyager spacecraft were poisedto cross the heliopause after completingtheir tour of the outer planets in the 1980s. In 2012, Voyager 1 registered a sharp increase in the density of interstellar particles, indicating that the spacecraft had passed out of the heliosphere and into the interstellar medium. The slower-moving Voyager 2 was set to pierce the heliopause along a different trajectory, but so far no measurements have shown that the spacecraft has bid farewell to oursolar system.In a recent study, ateam of scientists led by Haruichi Washimi (Kyushu University, Japan and CSPAR, University of Alabama-Huntsville) argues that models of the heliosphere can help explain this behavior. Because the heliopause location is controlled by factors that vary on many spatial and temporal scales, Washimiand collaborators turn to three-dimensional, time-dependent magnetohydrodynamics simulations of the heliosphere. In particular, they investigate how the position of the heliopause along the trajectories of Voyager 1 and Voyager 2 changes over time.Modeled location of the heliopause along the paths of Voyagers 1 (blue) and 2 (orange). Click for a closer look. The red star indicates the location at which Voyager

  12. Copépodes parasitos de fossas nasais de cinco espécies de peixes (Characiformes da planície de inundação do alto rio Paraná, Paraná, Brasil - DOI: 10.4025/actascibiolsci.v29i4.887 Parasitic copepods in the nasal fossae of five fish species (Characiformes from the upper Paraná river floodplain, Paraná, Brazil - DOI: 10.4025/actascibiolsci.v29i4.887

    Directory of Open Access Journals (Sweden)

    Maria de los Angeles Perez Lizama

    2008-02-01

    Full Text Available O presente trabalho teve como objetivo o estudo de copépodes parasitos de fossas nasais de peixes da planície de inundação do alto Rio Paraná. As coletas foram realizadas em diversos pontos da planície nos meses de março, junho e setembro de 2004. Foram coletados 73 exemplares de peixes da ordem Characiformes, de quatro famílias distintas, pertencentes a cinco espécies: Acestrorhynchus lacustris, Prochilodus lineatus, Schizodon borellii, Serrasalmus maculatus e Serrasalmus marginatus. Dentre os 73 peixes examinados, 53 encontravam-se parasitados por copépodes de fossas nasais, variando de 1 a 146 parasitos por peixe. Os parasitos encontrados pertenciam a três espécies conhecidas: Gamidactylus jaraquensis Thatcher & Boeger, 1984; Gamispatulus schizodontis Thatcher & Boeger, 1984 e Rhinergasilus piranhus Boeger & Thatcher, 1988. Diferenças foram observadas nas medidas corporais dos parasitos e na quantidade de espécies de parasitos por espécie de peixe em relação aos copépodes encontrados em estudos anteriores na região amazônica. O presente estudo constitui um dos poucos trabalhos de identificação de copépodes parasitos de fossas nasais de peixes da região Sul do Brazil.The present work had the objective to study parasitic copepods in the nasal fossae of fish from the upper Paraná river floodplain. Fish were captured in different locations of the floodplain in March, June and September, 2004. A total of 73 specimens (Characiformes were collected, belonging to 4 distinct families and 5 species: Acestrorhynchus lacustris (Acestrorhynchidae, Schizodon borellii (Anostomidae, Prochilodus lineatus (Prochilodontidae, Serrasalmus marginatus and Serrasalmus maculatus (Serrasalmidae. Among 73 fishes examined, 53 were parasitized by nasal fossae copepods, varying from 1 to 146 parasites per host. Parasites found belonged to 3 known species: Gamidactylus jaraquensis Thatcher & Boeger, 1984; Gamispatulus schizodontis Thatcher & Boeger

  13. X-point effect on edge stability

    International Nuclear Information System (INIS)

    Saarelma, S; Kirk, A; Kwon, O J

    2011-01-01

    We study the effects of the X-point configuration on edge localized mode (ELM) triggering peeling and ballooning modes using fixed boundary equilibria and modifying the plasma shape to approach the limit of a true X-point. The current driven pure peeling modes are asymptotically stabilized by the X-point while the stabilizing effect on ballooning modes depends on the poloidal location of the X-point. The coupled peeling-ballooning modes experience the elimination of the peeling component as the X-point is introduced. This can significantly affect the edge stability diagrams used to analyse the ELM triggering mechanisms.

  14. FINANCIAL STABILITY AS A FACTOR ECONOMIC SECURITY

    Directory of Open Access Journals (Sweden)

    A. V. Endovitskaya

    2015-01-01

    Full Text Available Summary. The article examines the linkages between financial stability and the level of its economic security. Considered the content of financial stability, represented by its own definition, we studied the basic conditions to achieve it. The logic diagram showing the location of financial stability and financial security to ensure the economic security of the business entity. A system of internal and external factors affecting the financial stability and endanger financial stability and financial security company. It has been established that it is the internal factors such as the availability of financial resources and financial position, capital structure, the company's ability to generate profits determine the level of economic security and its ability to withstand the negative impact of external and internal threats. The necessity of improving the financial sustainability in order to improve the economic security of the enterprise. On the basis of the research proposed matrix of risks affecting the financial stability and economic security, which allows to determine the probability of their occurrence and impact. It presents the economic, social, human, financial, organizational, economic, innovative and productive tools to increase the stability and financial security of an economic entity. List considered standard measures will make a plan of action to minimize the adverse impacts and enhance financial stability and security. Therefore, a prerequisite for the economic security of the enterprise is the attainment of financial stability.

  15. Elderly fallers enhance dynamic stability through anticipatory postural adjustments during a choice stepping reaction time

    Directory of Open Access Journals (Sweden)

    Romain Tisserand

    2016-11-01

    Full Text Available In the case of disequilibrium, the capacity to step quickly is critical to avoid falling for elderly. This capacity can be simply assessed through the choice stepping reaction time test (CSRT, where elderly fallers (F take longer to step than elderly non-fallers (NF. However, reasons why elderly F elongate their stepping time remain unclear. The purpose of this study is to assess the characteristics of anticipated postural adjustments (APA that elderly F develop in a stepping context and their consequences on the dynamic stability. 44 community-dwelling elderly subjects (20 F and 22 NF performed a CSRT where kinematics and ground reaction forces were collected. Variables were analyzed using two-way repeated measures ANOVAs. Results for F compared to NF showed that stepping time is elongated, due to a longer APA phase. During APA, they seem to use two distinct balance strategies, depending on the axis: in the anteroposterior direction, we measured a smaller backward movement and slower peak velocity of the center of pressure (CoP; in the mediolateral direction, the CoP movement was similar in amplitude and peak velocity between groups but lasted longer. The biomechanical consequence of both strategies was an increased margin of stability (MoS at foot-off, in the respective direction. By elongating their APA, elderly F use a safer balance strategy that prioritizes dynamic stability conditions instead of the objective of the task. Such a choice in balance strategy probably comes from muscular limitations and/or a higher fear of falling and paradoxically indicates an increased risk of fall.

  16. Copépodes, Cladocères et Rotifères du lac Sidi M'hamed Benali (Algérie Nord-Occidentale

    Directory of Open Access Journals (Sweden)

    Mohamed Ali Bouzidi

    2010-03-01

    Full Text Available En 2008, 33 espèces de Cladocères, Copépodes et Rotifères ont été observées dans le lac Sidi M'hamed Benali (contre 12 seulement en 1992.Les Copépodes dominent en mars, avril, juillet, août et septembre, avec respectivement des dominances (Do égales à : 56,6 %, 55,0 %, 55,0 %, 46,4 % et 90,0 %. Les Cladocères dominent en février (Do = 37,2 %, mai (Do = 47,4 % et décembre (Do = 48,6 %. Les Rotifères sont extrêmement abondants et présentent une large dominance en janvier (Do = 95,3 %. La population zooplanctonique est très faible en juillet et en août. Au cours de l'année le peuplement varie en fonction de la température, des conditions hydrologiques, de l'abondance de la nourriture et de la prédation par les poissons.In 2008, 33 species of Cladocers, Copepods and Rotifers have been observed in Sidi M’hamed Benali Lake (against only 12 species in 1992. The Copepods dominate in March, April, July, August and September, respectively with dominance (Do equal to 56.6 %, 55.0 %, 55.0 %, 46.4 % and 90.0 %. Cladocers dominated in February (Do = 37.2 %, May (Do = 47.4 % and December (Do = 48.6 %. The rotifers are extremely abundant and have a wide dominance in January (Do = 95.3%. The zooplankton population is very low in July and August. During the year, the population varies with temperature, water conditions, abundance of food and predation by fishes.

  17. International training program in support of safety analysis. 3D S.UN.COP-scaling uncertainty and 3D thermal-hydraulics/neutron-kinetics coupled codes seminars

    International Nuclear Information System (INIS)

    Petruzzi, Alessandro; D'Auria, Francesco; Bajs, Tomislav; Reventos, Francesc; Hassan, Yassin

    2007-01-01

    Thermal-hydraulic system computer codes are extensively used worldwide for analysis of nuclear facilities by utilities, regulatory bodies, nuclear power plant designers and vendors, nuclear fuel companies, research organizations, consulting companies, and technical support organizations. The computer code user represents a source of uncertainty that can influence the results of system code calculations. This influence is commonly known as the user effect' and stems from the limitations embedded in the codes as well as from the limited capability of the analysis to use the codes. Code user training and qualification is an effective means for reducing the variation of results caused by the application of the codes by different users. This paper describes a systematic approach to training code users who, upon completion of the training, should be able to perform calculations making the best possible use of the capabilities of best estimate codes. In other words, the program aims at contributing towards solving the problem of user effect. The 3D S.UN.COP (Scaling, Uncertainty and 3D COuPled code calculations) seminars have been organized as follow-up of the proposal to IAEA for the Permanent Training Course for System Code Users. Six seminars have been held at University of Pisa (2003, 2004), at The Pennsylvania State University (2004), at University of Zagreb (2005), at the School of Industrial Engineering of Barcelona (January-February 2006) and in Buenos Aires, Argentina (October 2006), being this last one requested by ARN (Autoridad Regulatoria Nuclear), NA-SA (Nucleoelectrica Argentina S.A) and CNEA (Comision Nacional de Energia Atomica). It was recognized that such courses represented both a source of continuing education for current code users and a mean for current code users to enter the formal training structure of a proposed 'permanent' stepwise approach to user training. The 3D S.UN.COP 2006 in Barcelona was successfully held with the attendance of 33

  18. International Training Program in Support of Safety Analysis: 3D S.UN.COP-Scaling, Uncertainty and 3D Thermal-Hydraulics/Neutron-Kinetics Coupled Codes Seminars

    International Nuclear Information System (INIS)

    Petruzzi, Alessandro; D'Auria, Francesco; Bajs, Tomislav; Reventos, Francesc

    2006-01-01

    Thermal-hydraulic system computer codes are extensively used worldwide for analysis of nuclear facilities by utilities, regulatory bodies, nuclear power plant designers and vendors, nuclear fuel companies, research organizations, consulting companies, and technical support organizations. The computer code user represents a source of uncertainty that can influence the results of system code calculations. This influence is commonly known as the 'user effect' and stems from the limitations embedded in the codes as well as from the limited capability of the analysts to use the codes. Code user training and qualification is an effective means for reducing the variation of results caused by the application of the codes by different users. This paper describes a systematic approach to training code users who, upon completion of the training, should be able to perform calculations making the best possible use of the capabilities of best estimate codes. In other words, the program aims at contributing towards solving the problem of user effect. The 3D S.UN.COP (Scaling, Uncertainty and 3D COuPled code calculations) seminars have been organized as follow-up of the proposal to IAEA for the Permanent Training Course for System Code Users [1]. Five seminars have been held at University of Pisa (2003, 2004), at The Pennsylvania State University (2004), at University of Zagreb (2005) and at the School of Industrial Engineering of Barcelona (2006). It was recognized that such courses represented both a source of continuing education for current code users and a mean for current code users to enter the formal training structure of a proposed 'permanent' stepwise approach to user training. The 3D S.UN.COP 2006 was successfully held with the attendance of 33 participants coming from 18 countries and 28 different institutions (universities, vendors, national laboratories and regulatory bodies). More than 30 scientists (coming from 13 countries and 23 different institutions) were

  19. International Training Program: 3D S. Un. Cop - Scaling, Uncertainty and 3D Thermal-Hydraulics/Neutron-Kinetics Coupled Codes Seminar

    International Nuclear Information System (INIS)

    Pertuzzi, A.; D'Auria, F.; Bajs, T.; Reventos, F.

    2006-01-01

    Thermal-hydraulic system computer codes are extensively used worldwide for analysis of nuclear facilities by utilities, regulatory bodies, nuclear power plant designers and vendors, nuclear fuel companies, research organizations, consulting companies, and technical support organizations. The computer code user represents a source of uncertainty that can influence the results of system code calculations. This influence is commonly known as the 'user effect' and stems from the limitations embedded in the codes as well as from the limited capability of the analysts to use the codes. Code user training and qualification is an effective means for reducing the variation of results caused by the application of the codes by different users. This paper describes a systematic approach to training code users who, upon completion of the training, should be able to perform calculations making the best possible use of the capabilities of best estimate codes. In other words, the program aims at contributing towards solving the problem of user effect. The 3D S.UN.COP (Scaling, Uncertainty and 3D COuPled code calculations) seminars have been organized as follow-up of the proposal to IAEA for the Permanent Training Course for System Code Users (D'Auria, 1998). Four seminars have been held at University of Pisa (2003, 2004), at The Pennsylvania State University (2004) and at University of Zagreb (2005). It was recognized that such courses represented both a source of continuing education for current code users and a mean for current code users to enter the formal training structure of a proposed 'permanent' stepwise approach to user training. The 3D S.UN.COP 2005 was successfully held with the participation of 19 persons coming from 9 countries and 14 different institutions (universities, vendors, national laboratories and regulatory bodies). More than 15 scientists were involved in the organization of the seminar, presenting theoretical aspects of the proposed methodologies and

  20. Global mapping of transposon location.

    Directory of Open Access Journals (Sweden)

    Abram Gabriel

    2006-12-01

    Full Text Available Transposable genetic elements are ubiquitous, yet their presence or absence at any given position within a genome can vary between individual cells, tissues, or strains. Transposable elements have profound impacts on host genomes by altering gene expression, assisting in genomic rearrangements, causing insertional mutations, and serving as sources of phenotypic variation. Characterizing a genome's full complement of transposons requires whole genome sequencing, precluding simple studies of the impact of transposition on interindividual variation. Here, we describe a global mapping approach for identifying transposon locations in any genome, using a combination of transposon-specific DNA extraction and microarray-based comparative hybridization analysis. We use this approach to map the repertoire of endogenous transposons in different laboratory strains of Saccharomyces cerevisiae and demonstrate that transposons are a source of extensive genomic variation. We also apply this method to mapping bacterial transposon insertion sites in a yeast genomic library. This unique whole genome view of transposon location will facilitate our exploration of transposon dynamics, as well as defining bases for individual differences and adaptive potential.

  1. Performance of the LHCb Vertex Locator

    CERN Document Server

    Aaij, R.; Akiba, K.; Alexander, M.; Ali, S.; Appleby, R.B.; Artuso, M.; Bates, A.; Bay, A.; Behrendt, O.; Benton, J.; van Beuzekom, M.; Bjornstad, P.M.; Bogdanova, G.; Borghi, S.; Borgia, A.; Bowcock, T.J.V.; van den Brand, J.; Brown, H.; Buytaert, J.; Callot, O.; Carroll, J.; Casse, G.; Collins, P.; De Capua, S.; Doets, M.; Donleavy, S.; Dossett, D.; Dumps, R.; Eckstein, D.; Eklund, L.; Farinelli, C.; Farry, S.; Ferro-Luzzi, M.; Frei, R.; Garofoli, J.; Gersabeck, M.; Gershon, T.; Gong, A.; Gong, H.; Gordon, H.; Haefeli, G.; Harrison, J.; Heijne, V.; Hennessy, K.; Hulsbergen, W.; Huse, T.; Hutchcroft, D.; Jaeger, A.; Jalocha, P.; Jans, E.; John, M.; Keaveney, J.; Ketel, T.; Korolev, M.; Kraan, M.; Lastovicka, T.; Lafferty, G.; Latham, T.; Lefeuvre, G.; Leflat, A.; Liles, M.; van Lysebetten, A.; MacGregor, G.; Marinho, F.; McNulty, R.; Merkin, M.; Moran, D.; Mountain, R.; Mous, I.; Mylroie-Smith, J.; Needham, M.; Nikitin, N.; Noor, A.; Oblakowska-Mucha, A.; Papadelis, A.; Pappagallo, M.; Parkes, C.; Patel, G.D.; Rakotomiaramanana, B.; Redford, S.; Reid, M.; Rinnert, K.; Rodrigues, E.; Saavedra, A.F.; Schiller, M.; Schneider, O.; Shears, T.; Silva Coutinho, R.; Smith, N.A.; Szumlak, T.; Thomas, C.; van Tilburg, J.; Tobin, M.; Velthuis, J.; Verlaat, B.; Viret, S.; Volkov, V.; Wallace, C.; Wang, J.; Webber, A.; Whitehead, M.; Zverev, E.

    2014-01-01

    The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in the LHCb experiment. The performance of the detector during the first years of its physics operation is reviewed. The system is operated in vacuum, uses a bi-phase CO2 cooling system, and the sensors are moved to 7 mm from the LHC beam for physics data taking. The performance and stability of these characteristic features of the detector are described, and details of the material budget are given. The calibration of the timing and the data processing algorithms that are implemented in FPGAs are described. The system performance is fully characterised. The sensors have a signal to noise ratio of approximately 20 and a best hit resolution of 4 microns is achieved at the optimal track angle. The typical detector occupancy for minimum bias events in standard operating conditions in 2011 is around 0.5%, and the detector has less than 1% of faulty strips. The proximity of the detector to the beam means ...

  2. Heat exchanger leakage problem location

    Directory of Open Access Journals (Sweden)

    Jícha Miroslav

    2012-04-01

    Full Text Available Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  3. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice, the CopD study

    DEFF Research Database (Denmark)

    Durup, D; Jørgensen, Henrik Løvendahl; Christensen, J.

    2012-01-01

    with higher mortality (P study from the general practice sector, a reverse J-shaped relation between the serum level of 25(OH)D and all-cause mortality was observed, indicating not only a lower limit but also an upper limit. The lowest mortality risk was at 50-60 nmol/liter......Context:Optimal levels of vitamin D have been a topic of heavy debate, and the correlation between 25-hydroxyvitamin D [25(OH)D] levels and mortality still remains to be established.Objective:The aim of the study was to determine the association between all-cause mortality and serum levels of 25(OH......)D, calcium, and PTH.Design and Setting:We conducted a retrospective, observational cohort study, the CopD Study, in a single laboratory center in Copenhagen, Denmark.Participants:Serum 25(OH)D was analyzed from 247,574 subjects from the Copenhagen general practice sector. In addition, serum levels of calcium...

  4. Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic.

    Science.gov (United States)

    He, Yanfang; Qi, Fei; Niu, Xiangheng; Zhang, Wenchi; Zhang, Xifeng; Pan, Jianming

    2018-08-27

    In clinical diagnosis, monitoring of uric acid (UA) is generally realized by combining uricase with natural peroxidase. The use of bio-enzymes, however, shadows some highlights of these methods due to their vulnerable activities against environments. Herein, we report a novel biosensor for the natural enzyme-free colorimetric detection of UA by using CoP nanosheet arrays grown on Ni foam (NF) as a monolithic peroxidase mimic. The integrated nanozyme can be put into and taken out from reaction systems conveniently with only tweezers, making it possible for on-demand analysis. As demonstrated, the obtained CoP/NF exhibits outstanding peroxidase-like activity to trigger the oxidation reaction of colorless 3,3'5,5'-tetramethylbenzidine (TMB) to a blue product (TMBox) mediated by H 2 O 2 . It is found that the blue TMBox can be reduced to colorless TMB again by UA selectively, thus the presence of UA in solutions will suppress the color reaction of TMB. Based on this principle, an uricase-free biosensor is developed for the photometric determination of UA, providing a wide detection range of 1-200 μM and a limit of detection down to 1.0 μM. In addition, the fabricated biosensor can be applied for measuring UA in clinical samples with merits of simple operation and good reliability, exhibiting its great promise in clinical diagnosis. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Effect of ball milling and dynamic compaction on magnetic properties of Al{sub 2}O{sub 3}/Co(P) composite particles

    Energy Technology Data Exchange (ETDEWEB)

    Denisova, E. A. [Kirensky Institute of Physics SB RAS, Krasnoyarsk (Russian Federation); Krasnoyarsk Institute of Railways Transport, Krasnoyarsk (Russian Federation); Kuzovnikova, L. A. [Krasnoyarsk Institute of Railways Transport, Krasnoyarsk (Russian Federation); Iskhakov, R. S., E-mail: rauf@iph.krasn.ru; Eremin, E. V. [Kirensky Institute of Physics SB RAS, Krasnoyarsk (Russian Federation); Bukaemskiy, A. A. [Institut fur Sicherheitsforschung und Reaktortechnik, D-52425 Juelich (Germany); Nemtsev, I. V. [Krasnoyarsk Scientific Center SB RAS, Krasnoyarsk (Russian Federation)

    2014-05-07

    The evolution of the magnetic properties of composite Al{sub 2}O{sub 3}/Co(P) particles during ball milling and dynamic compaction is investigated. To prepare starting composite particles, the Al{sub 2}O{sub 3} granules were coated with a Co{sub 95}P{sub 5} shell by electroless plating. The magnetic and structural properties of the composite particles are characterized by scanning electron microscopy, X-ray diffraction, and the use of the Physical Property Measurement System. The use of composite core-shell particles as starting powder for mechanoactivation allows to decrease treatment duration to 1 h and to produce a more homogeneous bulk sample than in the case of the mixture of Co and Al{sub 2}O{sub 3} powders. The magnetic properties of the milled composite particles are correlated with changes in the microstructure. Reduction in grain size of Co during milling leads to an increase of the volume fraction of superparamagnetic particles and to a decrease of the saturation magnetization. The local magnetic anisotropy field depends on the amount of hcp-Co phase in sample. The anisotropy field value decreases from 8.4 kOe to 3.8 kOe with an increase in milling duration up to 75 min. The regimes of dynamic compaction were selected so that the magnetic characteristics—saturation magnetization and coercive field—remained unchanged.

  6. Estimating location without external cues.

    Directory of Open Access Journals (Sweden)

    Allen Cheung

    2014-10-01

    Full Text Available The ability to determine one's location is fundamental to spatial navigation. Here, it is shown that localization is theoretically possible without the use of external cues, and without knowledge of initial position or orientation. With only error-prone self-motion estimates as input, a fully disoriented agent can, in principle, determine its location in familiar spaces with 1-fold rotational symmetry. Surprisingly, localization does not require the sensing of any external cue, including the boundary. The combination of self-motion estimates and an internal map of the arena provide enough information for localization. This stands in conflict with the supposition that 2D arenas are analogous to open fields. Using a rodent error model, it is shown that the localization performance which can be achieved is enough to initiate and maintain stable firing patterns like those of grid cells, starting from full disorientation. Successful localization was achieved when the rotational asymmetry was due to the external boundary, an interior barrier or a void space within an arena. Optimal localization performance was found to depend on arena shape, arena size, local and global rotational asymmetry, and the structure of the path taken during localization. Since allothetic cues including visual and boundary contact cues were not present, localization necessarily relied on the fusion of idiothetic self-motion cues and memory of the boundary. Implications for spatial navigation mechanisms are discussed, including possible relationships with place field overdispersion and hippocampal reverse replay. Based on these results, experiments are suggested to identify if and where information fusion occurs in the mammalian spatial memory system.

  7. Stability of Dolos Slopes

    DEFF Research Database (Denmark)

    Brorsen, Michael; Burcharth, Hans F.; Larsen, Torben

    The stability of dolos armour blocks against wave attack has been investigated in wave model studies.......The stability of dolos armour blocks against wave attack has been investigated in wave model studies....

  8. The LHCb VERTEX LOCATOR performance and VERTEX LOCATOR upgrade

    International Nuclear Information System (INIS)

    Rodríguez Pérez, P

    2012-01-01

    LHCb is an experiment dedicated to the study of new physics in the decays of beauty and charm hadrons at the Large Hadron Collider (LHC) at CERN. The Vertex Locator (VELO) is the silicon detector surrounding the LHCb interaction point. The detector operates in a severe and highly non-uniform radiation environment. The small pitch and analogue readout result in a best single hit precision of 4 μm. The upgrade of the LHCb experiment, planned for 2018, will transform the entire readout to a trigger-less system operating at 40 MHz event rate. The vertex detector will have to cope with radiation levels up to 10 16 1 MeVn eq /cm 2 , more than an order of magnitude higher than those expected at the current experiment. A solution is under development with a pixel detector, based on the Timepix/Medipix family of chips with 55 x 55 μm pixels. In addition a micro-strip solution is also under development, with finer pitch, higher granularity and lower mass than the current detector. The current status of the VELO will be described together with recent testbeam results.

  9. The Effects of Horizontal-Tail Location and Wing Modifications on the High-Speed Stability and Control Characteristics of a 01.17-Scale Model of the McDonnell XF2H-1 Airplane (TED No, NACA DE336)

    Science.gov (United States)

    Emerson, Horace F.; Axelson, John A.

    1949-01-01

    An additional series of high-speed wind-tunnel tests of a modified 0.17-scale model of the McDonnell XF2H-1 airplane was conducted to evaluate the effects of a reduction in the thickness-to-chord ratios of the tail planes, the displacement of the horizontal tail relative to the vertical tail, and the extension of the trailing edge of the wing. Two tail-intersection fairings designed to improve the flow at the tail were also tested. The pitching-moment characteristics of the model were improved slightly by the use of the thinner tail sections. Rearward or rearward and downward displacements of the horizontal tail increased the critical Mach number at the tail intersection from 0.725 to a maximum of 0.80, but caused an excessive change in pitching-moment coefficient at the higher Mach numbers. Extending the trailing edge of the wing did not improve the static longitudinal-stability characteristics, but increased the pitching-down tendency between 0.725 and 0.825 Mach numbers prior to the pitching-up tendency. The extended wing did, however, increase the Mach numbers at which these tendencies occurred. The increase in the Mach numbers of divergence and the tuft studies indicate a probable increase in the buffet limit of the prototype airplane. No perceptible improvement of flow at the tail intersection was observed with the two fairings tested on the forward tail configuration.

  10. Stability of parallel flows

    CERN Document Server

    Betchov, R

    2012-01-01

    Stability of Parallel Flows provides information pertinent to hydrodynamical stability. This book explores the stability problems that occur in various fields, including electronics, mechanics, oceanography, administration, economics, as well as naval and aeronautical engineering. Organized into two parts encompassing 10 chapters, this book starts with an overview of the general equations of a two-dimensional incompressible flow. This text then explores the stability of a laminar boundary layer and presents the equation of the inviscid approximation. Other chapters present the general equation

  11. Older adults prioritize postural stability in the anterior-posterior direction to regain balance following volitional lateral step.

    Science.gov (United States)

    Porter, Shaun; Nantel, Julie

    2015-02-01

    Postural control in the medial-lateral (ML) direction is of particular interest regarding the assessment of changes in postural control, as it is highly related to the risk of falling. To determine the postural strategies used to regain balance following a voluntary lateral step and compare these strategies between young and older adults. Sixteen older adults (60-90 years) and 14 young adults (20-40 years) were asked to stand quietly for 30s, walk in place and then take a lateral step and stand quietly (30s). Balance Post was divided into 10s intervals. Center of pressure displacement (CoP) and velocity (VCoP) in the anterio-posterior (AP) and ML directions were analyzed. In both groups, CoP and VCoP in AP and ML increased in Post1 compared to Pre (Padults, VCoP-Post2, Post3 ML were larger than Pre (P=0.01) in older adults. Age correlated with all VCoP (Pre and Post) in both ML (Padults, older adults use different postural strategies in ML and AP directions and prioritized postural stability in the AP direction to recover balance after completing a lateral step. In the ML direction, older adults took up to 30s to regain balance. Considering that age was related to larger CoP displacement and velocity, the AP strategy to recover postural balance following a lateral step could become less efficient as older adults age and therefore increasing the risk of falls. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. The BWR Stability Issue

    International Nuclear Information System (INIS)

    D'Auria, F.

    2008-01-01

    The purpose of this paper is to supply general information about Boiling Water Reactor (BWR) stability. The main concerned topics are: phenomenological aspects, experimental database, modelling features and capabilities, numerical models, three-dimensional modelling, BWR system performance during stability, stability monitoring and licensing aspects.

  13. Genotype x environment interaction and stability analysis for yield ...

    African Journals Online (AJOL)

    etc

    2015-05-06

    . Combined analysis of variance (ANOVA) for yield and yield components revealed highly significant .... yield stability among varieties, multi-location trials with ... Mean grain yield (kg/ha) of 17 Kabuli-type chickpea genotypes ...

  14. Quasiconvex optimization and location theory

    CERN Document Server

    Santos Gromicho, Jaoquim António

    1998-01-01

    grams of which the objective is given by the ratio of a convex by a positive (over a convex domain) concave function. As observed by Sniedovich (Ref. [102, 103]) most of the properties of fractional pro­ grams could be found in other programs, given that the objective function could be written as a particular composition of functions. He called this new field C­ programming, standing for composite concave programming. In his seminal book on dynamic programming (Ref. [104]), Sniedovich shows how the study of such com­ positions can help tackling non-separable dynamic programs that otherwise would defeat solution. Barros and Frenk (Ref. [9]) developed a cutting plane algorithm capable of optimizing C-programs. More recently, this algorithm has been used by Carrizosa and Plastria to solve a global optimization problem in facility location (Ref. [16]). The distinction between global optimization problems (Ref. [54]) and generalized convex problems can sometimes be hard to establish. That is exactly the reason ...

  15. Uncommon locations of hydatid cyst

    International Nuclear Information System (INIS)

    Bal, N.; Kocer, Nazim E.; Kayaselcuk, F.; Ezer, A.; Arpaci, R.

    2008-01-01

    The objective was to document the hydatid cyst cases in the endemic Cukurova region of Turkey, by their involvement sites in the body, and discuss the clinical and morphological features of the cases with rare localization. Archival materials of 153 hydatid cyst cases that were diagnosed in 2 different medical centers in Adana, Turkey Cukurova region between the years 2000-2006 were included in the study. Cases with rare localizations were re-evaluated in terms of clinical and laboratory findings, and histopathological features. Involvement sites of the cases were documented, cases with rare localizations are discussed. The liver was the most common localization with 63 cases followed by lungs with 54 cases. Uncommon locations were spleen n=4, bone n=3, intra-arterial n=1, ovary n=1, adrenal n=1, heart n=1, mesenteric n=2, retroperitoneal n=2, subcutaneous tissue n=4, breast n=1, intramuscular tissue n=4. The diagnosis of hydatic cyst should be considered in patients with a cystic mass, who live or have lived in a geographic region that has a high risk for Echinococcus granulosus, or visited an endemic area. (author)

  16. Feedback stabilization initiative

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    Much progress has been made in attaining high confinement regimes in magnetic confinement devices. These operating modes tend to be transient, however, due to the onset of MHD instabilities, and their stabilization is critical for improved performance at steady state. This report describes the Feedback Stabilization Initiative (FSI), a broad-based, multi-institutional effort to develop and implement methods for raising the achievable plasma betas through active MHD feedback stabilization. A key element in this proposed effort is the Feedback Stabilization Experiment (FSX), a medium-sized, national facility that would be specifically dedicated to demonstrating beta improvement in reactor relevant plasmas by using a variety of MHD feedback stabilization schemes.

  17. Feedback stabilization initiative

    International Nuclear Information System (INIS)

    1997-06-01

    Much progress has been made in attaining high confinement regimes in magnetic confinement devices. These operating modes tend to be transient, however, due to the onset of MHD instabilities, and their stabilization is critical for improved performance at steady state. This report describes the Feedback Stabilization Initiative (FSI), a broad-based, multi-institutional effort to develop and implement methods for raising the achievable plasma betas through active MHD feedback stabilization. A key element in this proposed effort is the Feedback Stabilization Experiment (FSX), a medium-sized, national facility that would be specifically dedicated to demonstrating beta improvement in reactor relevant plasmas by using a variety of MHD feedback stabilization schemes

  18. RCRA facility stabilization initiative

    International Nuclear Information System (INIS)

    1995-02-01

    The RCRA Facility Stabilization Initiative was developed as a means of implementing the Corrective Action Program's management goals recommended by the RIS for stabilizing actual or imminent releases from solid waste management units that threaten human health and the environment. The overall goal of stabilization is to, as situations warrant, control or abate threats to human health and/or the environment from releases at RCRA facilities, and/or to prevent or minimize the further spread of contamination while long-term remedies are pursued. The Stabilization initiative is a management philosophy and should not be confused with stabilization technologies

  19. Muscular condition and trunk stability in judoka of national and international level

    Directory of Open Access Journals (Sweden)

    Casto Juan-Recio

    2013-12-01

    Full Text Available Background: It is theorized that the development of the ability to stabilize the trunk may improve the performance of a judoka because it improves body balance control and optimizes force transmission from the lower extremities to the upper limbs. However, there is a lack of scientific evidence to establish a clear relationship between trunk stability and performance in judo.Aim: The purpose of this study was to determine whether the quantification of trunk stability and muscular strength and endurance allowed differentiation between national level (n = 7 and international level judoka (n = 6. In addition, the relationship between trunk stability and muscular strength and endurance of the muscles involved in trunk stability control was analyzed.Method: To assess trunk stability, trunk responses to sudden loads applied by a pneumatic mechanism were analyzed, as well as trunk postural control through an unstable sitting paradigm. Muscular strength and endurance were assessed via a flexion and extension trunk test using an isokinetic dynamometer.Results/Conclusions: International level judokas showed lower CoP displacement in the most complex task in unstable seat (7.00 ± 1.19 vs 8.93 ± 1.45 mm, T = .025 and higher absolute and relative peak torque in extensor muscles (7.05 ± 0.87 vs 5.74 ± 0.72 Nm, T = .013 than national level judoka. According to these results, core stability and trunk muscular condition are important qualities in the physical training of elite judoka. Correlational analysis found no relation between the analyzed variables, thus muscular strength and endurance appear to have a non-significant effect on performance in the trunk stability tests.

  20. Privacy-Preserving Location-Based Services

    Science.gov (United States)

    Chow, Chi Yin

    2010-01-01

    Location-based services (LBS for short) providers require users' current locations to answer their location-based queries, e.g., range and nearest-neighbor queries. Revealing personal location information to potentially untrusted service providers could create privacy risks for users. To this end, our objective is to design a privacy-preserving…

  1. 11th International Seminar on Stability Problems for Stochastic Models

    CERN Document Server

    Zolotarev, Vladimir

    1989-01-01

    Traditionally the Stability seminar, organized in Moscow but held in different locations, has dealt with a spectrum of topics centering around characterization problems and their stability, limit theorems, probabil- ity metrics and theoretical robustness. This volume likewise focusses on these main topics in a series of original and recent research articles.

  2. Yield Stability of Sorghum Hybrids and Parental Lines | Kenga ...

    African Journals Online (AJOL)

    Seventy-five sorghum hybrids and twenty parental lines were evaluated for two consecutive years at two locations. Our objective was to compare relative stability of grain yields among hybrids and parental lines. Mean grain yields and stability analysis of variance, which included linear regression coefficient (bi) and ...

  3. Privacy for location-based services

    CERN Document Server

    Ghinita, Gabriel

    2013-01-01

    Sharing of location data enables numerous exciting applications, such as location-based queries, location-based social recommendations, monitoring of traffic and air pollution levels, etc. Disclosing exact user locations raises serious privacy concerns, as locations may give away sensitive information about individuals' health status, alternative lifestyles, political and religious affiliations, etc. Preserving location privacy is an essential requirement towards the successful deployment of location-based applications. These lecture notes provide an overview of the state-of-the-art in locatio

  4. Association of Stability Parameters and Yield Stability of Sesame ...

    African Journals Online (AJOL)

    Association of Stability Parameters and Yield Stability of Sesame ( Sesamum ... Information on phenotypic stability is useful for the selection of crop varieties as well as for ... as an alternative to parametric stability measurements is important.

  5. Secular stability of rotating stars

    International Nuclear Information System (INIS)

    Imamura, J.N.; Friedman, J.L.; Durisen, R.H.

    1984-01-01

    In this work, the authors calculate the secular stability limits of rotating polytropes to nonaxisymmetric perturbations of low m. Polytropic indices ranging from 1 to 3 and several angular momentum distributions are considered. Results are most conveniently presented in terms of the t-parameter, defined as the ratio of the rotational kinetic energy to the absolute value of the gravitational energy of the fluid. Previous work on polytropes considered only the m = 2 mode, which is unstable for values of the t-parameter greater than 0.14 +- 0.01 for the n values n = 1.5 and 3 and the angular momentum distributions tested (see Durisen and Imamura 1981). The GRR secular stability limit of the m - 2 mode for the Maclaurin spheroids (n = 0) was determined by Chandrasekhar (1970). GRR stability limits of higher m modes for the Maclaurin spheroids were located approximately by Comins (1979a,b) and more precisely by Friedman (1983). 16 references, 2 tables

  6. Location based services in smartphones

    OpenAIRE

    Ματσιούλας, Κωνσταντίνος

    2015-01-01

    Η κινητή υπολογιστική εξελίσσεται συνεχώς και με ταχύ ρυθμό. Κάθε μέρα εισάγονται νέες κινητές συσκευές, τεχνολογίες, μέθοδοι, και εφαρμογές. Πρόσφατα, μία από τις κινητές εφαρμογές, η υπηρεσία αξιοποίησης της γεωγραφικής θέσης (Location-Based Service – LBS), έχει τραβήξει έντονα την προσοχή. Μία τέτοια υπηρεσία βασίζεται στην γεωγραφική θέση μίας κινητής συσκευής χειρός (π.χ. ένα κινητό τηλέφωνο και συγκεκριμένα ένα έξυπνο τηλέφωνο –smartphone). Αν και οι υπηρεσίες LBS είναι πολύ δημοφιλείς,...

  7. International training program: 3D S.UN.COP - Scaling, uncertainty and 3D thermal-hydraulics/neutron-kinetics coupled codes seminar

    International Nuclear Information System (INIS)

    Petruzzi, A.; D'Auria, F.; Bajs, T.; Reventos, F.

    2006-01-01

    Thermal-hydraulic system computer codes are extensively used worldwide for analysis of nuclear facilities by utilities, regulatory bodies, nuclear power plant designers and vendors, nuclear fuel companies, research organizations, consulting companies, and technical support organizations. The computer code user represents a source of uncertainty that can influence the results of system code calculations. This influence is commonly known as the 'user effect' and stems from the limitations embedded in the codes as well as from the limited capability of the analysts to use the codes. Code user training and qualification is an effective means for reducing the variation of results caused by the application of the codes by different users. This paper describes a systematic approach to training code users who, upon completion of the training, should be able to perform calculations making the best possible use of the capabilities of best estimate codes. In other words, the program aims at contributing towards solving the problem of user effect. The 3D S.UN.COP 2005 (Scaling, Uncertainty and 3D COuPled code calculations) seminar has been organized by University of Pisa and University of Zagreb as follow-up of the proposal to IAEA for the Permanent Training Course for System Code Users (D'Auria, 1998). It was recognized that such a course represented both a source of continuing education for current code users and a means for current code users to enter the formal training structure of a proposed 'permanent' stepwise approach to user training. The seminar-training was successfully held with the participation of 19 persons coming from 9 countries and 14 different institutions (universities, vendors, national laboratories and regulatory bodies). More than 15 scientists were involved in the organization of the seminar, presenting theoretical aspects of the proposed methodologies and holding the training and the final examination. A certificate (LA Code User grade) was released

  8. Stability of Hyperthermophilic Proteins

    DEFF Research Database (Denmark)

    Stiefler-Jensen, Daniel

    stability by randomly generate mutants and lengthy screening processes to identify the best new mutants. However, with the increase in available genomic sequences of thermophilic or hyperthermophilic organisms a world of enzymes with intrinsic high stability are now available. As these organisms are adapted...... to life at high temperatures so are their enzymes, as a result the high stability is accompanied by low activity at moderate temperatures. Thus, much effort had been put into decoding the mechanisms behind the high stability of the thermophilic enzymes. The hope is to enable scientist to design enzymes...... in the high stability of hyperthermophilic enzymes. The thesis starts with an introduction to the field of protein and enzyme stability with special focus on the thermophilic and hyperthermophilic enzymes and proteins. After the introduction three original research manuscripts present the experimental data...

  9. Are Stabilization Programs Expansionary?

    OpenAIRE

    Federico Echenique; Alvaro Forteza

    1997-01-01

    The empirical evidence presented in this paper casts serious doubts on the by now widely accepted "stylized facts" of the exchange rate based stabilization programs (ERBS) as they are stated in Kiguel and Liviatan (1992) and in Végh (1992). Even though the ERBS programs were associated with output booms, no evidence of booms provoked by the stabilization programs is found. Rather, exogenous capital inflows to Latin America seem to have caused both the output booms and the stabilization progra...

  10. Mining Significant Semantic Locations from GPS Data

    DEFF Research Database (Denmark)

    Cao, Xin; Cong, Gao; Jensen, Christian Søndergaard

    2010-01-01

    With the increasing deployment and use of GPS-enabled devices, massive amounts of GPS data are becoming available. We propose a general framework for the mining of semantically meaningful, significant locations, e.g., shopping malls and restaurants, from such data. We present techniques capable...... of extracting semantic locations from GPS data. We capture the relationships between locations and between locations and users with a graph. Significance is then assigned to locations using random walks over the graph that propagates significance among the locations. In doing so, mutual reinforcement between...

  11. Mining significant semantic locations from GPS data

    DEFF Research Database (Denmark)

    Cao, Xin; Cong, Gao; Jensen, Christian S.

    2010-01-01

    With the increasing deployment and use of GPS-enabled devices, massive amounts of GPS data are becoming available. We propose a general framework for the mining of semantically meaningful, significant locations, e.g., shopping malls and restaurants, from such data. We present techniques capable...... of extracting semantic locations from GPS data. We capture the relationships between locations and between locations and users with a graph. Significance is then assigned to locations using random walks over the graph that propagates significance among the locations. In doing so, mutual reinforcement between...

  12. Internet Addiction: Stability and Change

    Science.gov (United States)

    Huang, Chiungjung

    2010-01-01

    This longitudinal study examined five indices of stability and change in Internet addiction: structural stability, mean-level stability, differential stability, individual-level stability, and ipsative stability. The study sample was 351 undergraduate students from end of freshman year to end of junior year. Convergent findings revealed stability…

  13. Metals and Alloys Material Stabilization Process Plan

    Energy Technology Data Exchange (ETDEWEB)

    RISENMAY, H.R.; BURK, R.A.

    2000-05-18

    This Plan outlines the process for brushing metal and alloys in accordance with the path forward discussed in the Integrated Project Management Plan for the Plutonium Finishing Plant Stabilization and Deactivation Project, HNF-3617, and requirements set forth in the Project Management Plan for Materials Stabilization, HNF-3605. This plan provides the basis for selection of the location to process, the processes involved, equipment to be used, and the characterization of the contents of the can. The scope of the process is from retrieval of metals and alloys from storage to transfer back to storage in a repackaged configuration.

  14. Metals and Alloys Material Stabilization Process Plan

    International Nuclear Information System (INIS)

    RISENMAY, H.R.; BURK, R.A.

    2000-01-01

    This Plan outlines the process for brushing metal and alloys in accordance with the path forward discussed in the Integrated Project Management Plan for the Plutonium Finishing Plant Stabilization and Deactivation Project, HNF-3617, and requirements set forth in the Project Management Plan for Materials Stabilization, HNF-3605. This plan provides the basis for selection of the location to process, the processes involved, equipment to be used, and the characterization of the contents of the can. The scope of the process is from retrieval of metals and alloys from storage to transfer back to storage in a repackaged configuration

  15. 76 FR 44892 - Information Collection; Locatable Minerals

    Science.gov (United States)

    2011-07-27

    ... DEPARTMENT OF AGRICULTURE Forest Service Information Collection; Locatable Minerals AGENCY: Forest... on the extension of a currently approved information collection, Locatable Minerals-36 CFR part 228...: Comments concerning this notice should be addressed to: USDA, Forest Service, Minerals and Geology...

  16. Location | Frederick National Laboratory for Cancer Research

    Science.gov (United States)

    The Frederick National Laboratory for Cancer Research campus is located 50 miles northwest of Washington, D.C., and 50 miles west of Baltimore, Maryland, in Frederick, Maryland. Satellite locations include leased and government facilities extending s

  17. Sandia National Laboratories: Locations: Kauai Test Facility

    Science.gov (United States)

    Locations Contact Us Employee Locator Search Menu About Leadership Mission Social Media Community History Diversity Social Media Careers View All Jobs Students & Postdocs Benefits & Perks Hiring Technology Deployment Centers New Mexico Small Business Assistance Program Sandia's Economic Impact Sandia

  18. HSIP Law Enforcement Locations in New Mexico

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Law Enforcement Locations Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law Enforcement agencies "are publicly...

  19. National Archives and Records Administration Employee Locator

    Data.gov (United States)

    National Archives and Records Administration — The National Archives and Records Administration Employee Locator is an online system that provides the name, office symbol, location, room, telephone number, and...

  20. Recycling Facilities - Land Recycling Cleanup Locations

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Land Recycling Cleanup Location Land Recycling Cleanup Locations (LRCL) are divided into one or more sub-facilities categorized as media: Air, Contained Release or...

  1. CARAVAN: Providing Location Privacy for VANET

    National Research Council Canada - National Science Library

    Sampigethaya, Krishna; Huang, Leping; Li, Mingyan; Poovendran, Radha; Matsuura, Kanta; Sezaki, Kaoru

    2005-01-01

    .... This type of tracking leads to threats on the location privacy of the vehicle's user. In this paper, we study the problem of providing location privacy in VANET by allowing vehicles to prevent tracking of their broadcast communications...

  2. An IBeacon-Based Location System for Smart Home Control.

    Science.gov (United States)

    Liu, Qinghe; Yang, Xinshuang; Deng, Lizhen

    2018-06-11

    Indoor location and intelligent control system can bring convenience to people’s daily life. In this paper, an indoor control system is designed to achieve equipment remote control by using low-energy Bluetooth (BLE) beacon and Internet of Things (IoT) technology. The proposed system consists of five parts: web server, home gateway, smart terminal, smartphone app and BLE beacons. In the web server, fingerprint matching based on RSSI stochastic characteristic and posture recognition model based on geomagnetic sensing are used to establish a more efficient equipment control system, combined with Pedestrian Dead Reckoning (PDR) technology to improve the accuracy of location. A personalized menu of remote “one-click” control is finally offered to users in a smartphone app. This smart home control system has been implemented by hardware, and precision and stability tests have been conducted, which proved the practicability and good user experience of this solution.

  3. 200 Area plateau inactive miscellaneous underground storage tanks locations

    International Nuclear Information System (INIS)

    Brevick, C.H.

    1997-01-01

    Fluor Daniel Northwest (FDNW) has been tasked by Lockheed Martin Hanford Corporation (LMHC) to incorporate current location data for 64 of the 200-Area plateau inactive miscellaneous underground storage tanks (IMUST) into the centralized mapping computer database for the Hanford facilities. The IMUST coordinate locations and tank names for the tanks currently assigned to the Hanford Site contractors are listed in Appendix A. The IMUST are inactive tanks installed in underground vaults or buried directly in the ground within the 200-East and 200-West Areas of the Hanford Site. The tanks are categorized as tanks with a capacity of less than 190,000 liters (50,000 gal). Some of the IMUST have been stabilized, pumped dry, filled with grout, or may contain an inventory or radioactive and/or hazardous materials. The IMUST have been out of service for at least 12 years

  4. Stability of Cholesterol, 7-Ketocholesterol and β-Sitosterol during Saponification: Ramifications for Artifact Monitoring of Sterol Oxide Products.

    Science.gov (United States)

    Busch, T P; King, A J

    2010-09-01

    Cholesterol has been used to monitor artifact generation. Stability differences among cholesterol oxide products (COPs) and cholesterol in thermal and alkaline conditions are theorized. Thus, use of cholesterol may be unsuitable for detection of artifacts generated from COPs. Stability of cholesterol was compared to that of 7-ketocholesterol (7-keto) and β-sitosterol (βS) under various thermal and alkaline saponification conditions: 1 M methanolic KOH for 18 h at 24 °C (1 M18hr24°C, Control), 18 h at 37 °C (1M18hr37°C), 3 h at 45 °C (1M3hr45°C), and 3.6 M methanolic KOH for 3 h at 24 °C (3.6M3hr24°C). Trends indicated that cholesterol in solution was more stable than 7-keto under all conditions. Compared to βS, cholesterol was more stable under all conditions except for 1M18hr37°C for which stabilities were similar. Compounds were more labile in heat than alkalinity. Poor recoveries of 7-keto during cold saponification with high alkalinity were attributed to alkaline instability. 7-Keto, less stable than cholesterol, should be used to monitor artifact generation during screening of various methods that include thermal and alkaline conditions. In a preliminary analysis of turkey meat, more 3,5-7-one was generated from spiking with cholesterol than with 7-keto.

  5. Simulation analysis for hyperbola locating accuracy

    International Nuclear Information System (INIS)

    Wang Changli; Liu Daizhi

    2004-01-01

    In the system of the hyperbola location, the geometric shape of the detecting stations has an important influence on the locating accuracy. At first, this paper simulates the process of the hyperbola location by the computer, and then analyzes the influence of the geometric shape on the locating errors and gives the computer simulation results, finally, discusses the problems that require attention in course of selecting the detecting station. The conclusion has practicality. (authors)

  6. Open Location Management in Automated Warehousing Systems

    OpenAIRE

    Yu, Yugang; Koster, René

    2009-01-01

    textabstractA warehouse needs to have sufficient open locations to be able to store incoming shipments of various sizes. In combination with ongoing load retrievals open locations gradually spread over the storage area. Unfavorable positions of open locations negatively impact the average load retrieval times. This paper presents a new method to manage these open locations such that the average system travel time for processing a block of storage and retrieval jobs in an automated warehousing...

  7. A Wireless Location System in LTE Networks

    OpenAIRE

    Liu, Qi; Hu, Rongyi; Liu, Shan

    2017-01-01

    Personal location technologies are becoming important with the rapid development of Mobile Internet services. In traditional cellular networks, the key problems of user location technologies are high-precision synchronization among different base stations, inflexible processing resources, and low accuracy positioning, especially for indoor environment. In this paper, a new LTE location system in Centralized Radio Access Network (C-RAN) is proposed, which makes channel and location measurement...

  8. Spatial quality, location theory and spatial planning

    NARCIS (Netherlands)

    Assink, Mathijs; Groenendijk, Nico

    2009-01-01

    This paper deals with spatial quality as a possible factor in location choices made by companies. Actual location decisions as well as location theory have changed over time. In the industrial era primary “hard” cost factors were dominant, to be supplemented by agglomeration factors ever since the

  9. 47 CFR 101.129 - Transmitter location.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Transmitter location. 101.129 Section 101.129... SERVICES Technical Standards § 101.129 Transmitter location. (a) The applicant must determine, prior to... adequate to render the service proposed. In cases of questionable antenna locations, it is desirable to...

  10. 46 CFR 193.50-10 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Location. 193.50-10 Section 193.50-10 Shipping COAST... Details § 193.50-10 Location. (a) Approved hand portable fire extinguishers and semiportable fire extinguishing systems shall be installed in accordance with Table 193.50-10(a). The location of the equipment...

  11. 46 CFR 108.493 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Location. 108.493 Section 108.493 Shipping COAST GUARD... Extinguishing Systems Hand Portable and Semiportable Fire Extinguishing Systems § 108.493 Location. (a) Each... this subpart and installed in the locations prescribed in the table. (b) Each portable and semi...

  12. 47 CFR 73.1120 - Station location.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Station location. 73.1120 Section 73.1120... Rules Applicable to All Broadcast Stations § 73.1120 Station location. Each AM, FM, TV and Class A TV... be the geographical station location. [65 FR 30003, May 10, 2000] ...

  13. 46 CFR 95.50-10 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Location. 95.50-10 Section 95.50-10 Shipping COAST GUARD...-10 Location. (a) Approved hand portable fire extinguishers and semiportable fire extinguishing systems shall be installed in accordance with Table 95.50-10(a). The location of the equipment shall be to...

  14. 46 CFR 76.50-10 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Location. 76.50-10 Section 76.50-10 Shipping COAST GUARD... Extinguishers and Semiportable Fire Extinguishing Systems, Arrangements and Details § 76.50-10 Location. (a... fire extinguishing systems Classification (see § 76.50-5) Quantity and location Safety area 1...

  15. 49 CFR 195.260 - Valves: Location.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valves: Location. 195.260 Section 195.260... PIPELINE Construction § 195.260 Valves: Location. A valve must be installed at each of the following locations: (a) On the suction end and the discharge end of a pump station in a manner that permits isolation...

  16. 7 CFR 1924.106 - Location.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Location. 1924.106 Section 1924.106 Agriculture... CONSTRUCTION AND REPAIR Planning and Performing Site Development Work § 1924.106 Location. (a) General. It is... will not finance development on locations that adversely affect properties which are listed or are...

  17. Open Location Management in Automated Warehousing Systems

    NARCIS (Netherlands)

    Y. Yu (Yugang); M.B.M. de Koster (René)

    2009-01-01

    textabstractA warehouse needs to have sufficient open locations to be able to store incoming shipments of various sizes. In combination with ongoing load retrievals open locations gradually spread over the storage area. Unfavorable positions of open locations negatively impact the average load

  18. Bounds in the location-allocation problem

    DEFF Research Database (Denmark)

    Juel, Henrik

    1981-01-01

    Develops a family of stronger lower bounds on the objective function value of the location-allocation problem. Solution methods proposed to solve problems in location-allocation; Efforts to develop a more efficient bound solution procedure; Determination of the locations of the sources....

  19. LOCATION-BASED SERVICES USING SIP

    OpenAIRE

    Abdullah Azfar,; Md. Sakhawat Hossen,; María José Peroza Marval; Razib Hayat Khan

    2010-01-01

    Due to the popularity of Location-Based Services and IP telephony, we decided to review a number of different proposals to implement Location-Based Services over a SIP-based mobile network. The result is an interesting overview about the potential functionalities of Location-Based Services and the capabilities of SIP for implementingthese services.

  20. Multi-dimensional indoor location information model

    NARCIS (Netherlands)

    Xiong, Q.; Zhu, Q.; Zlatanova, S.; Huang, L.; Zhou, Y.; Du, Z.

    2013-01-01

    Aiming at the increasing requirements of seamless indoor and outdoor navigation and location service, a Chinese standard of Multidimensional Indoor Location Information Model is being developed, which defines ontology of indoor location. The model is complementary to 3D concepts like CityGML and

  1. Head stabilization in whooping cranes

    Science.gov (United States)

    Kinloch, M.R.; Cronin, T.W.; Olsen, Glenn H.; Chavez-Ramirez, Felipe

    2005-01-01

    The whooping crane (Grus americana) is the tallest bird in North America, yet not much is known about its visual ecology. How these birds overcome their unusual height to identify, locate, track, and capture prey items is not well understood. There have been many studies on head and eye stabilization in large wading birds (herons and egrets), but the pattern of head movement and stabilization during foraging is unclear. Patterns of head movement and stabilization during walking were examined in whooping cranes at Patuxent Wildlife Research Center, Laurel, Maryland USA. Four whooping cranes (1 male and 3 females) were videotaped for this study. All birds were already acclimated to the presence of people and to food rewards. Whooping cranes were videotaped using both digital and Hi-8 Sony video cameras (Sony Corporation, 7-35 Kitashinagawa, 6-Chome, Shinagawa-ku, Tokyo, Japan), placed on a tripod and set at bird height in the cranes' home pens. The cranes were videotaped repeatedly, at different locations in the pens and while walking (or running) at different speeds. Rewards (meal worms, smelt, crickets and corn) were used to entice the cranes to walk across the camera's view plane. The resulting videotape was analyzed at the University of Maryland at Baltimore County. Briefly, we used a computerized reduced graphic model of a crane superimposed over each frame of analyzed tape segments by means of a custom written program (T. W. Cronin, using C++) with the ability to combine video and computer graphic input. The speed of the birds in analyzed segments ranged from 0.30 m/s to 2.64 m/s, and the proportion of time the head was stabilized ranged from 79% to 0%, respectively. The speed at which the proportion reached 0% was 1.83 m/s. The analyses suggest that the proportion of time the head is stable decreases as speed of the bird increases. In all cases, birds were able to reach their target prey with little difficulty. Thus when cranes are walking searching for food

  2. Microwave stability at transition

    International Nuclear Information System (INIS)

    Holt, J.A.; Colestock, P.L.

    1995-05-01

    The question of microwave stability at transition is revisited using a Vlasov approach retaining higher order terms in the particle dynamics near the transition energy. A dispersion relation is derived which can be solved numerically for the complex frequency in terms of the longitudinal impedance and other beam parameters. Stability near transition is examined and compared with simulation results

  3. Beam stabilization at SPEAR

    International Nuclear Information System (INIS)

    Corbett, J.

    1996-01-01

    The SPEAR storage ring began routine synchrotron radiation operation with a dedicated injector in 1990. Since then, a program to improve beam stability has steadily progressed. This paper, based on a seminar given at a workshop on storage ring optimization (1995 SRI conference) reviews the beam stability program for SPEAR. copyright 1996 American Institute of Physics

  4. Visual attention and stability

    NARCIS (Netherlands)

    Mathot, Sebastiaan; Theeuwes, Jan

    2011-01-01

    In the present review, we address the relationship between attention and visual stability. Even though with each eye, head and body movement the retinal image changes dramatically, we perceive the world as stable and are able to perform visually guided actions. However, visual stability is not as

  5. Electrode stabilizing materials

    Science.gov (United States)

    Amine, Khalil; Abouimrane, Ali; Moore, Jeffrey S.; Odom, Susan A.

    2015-11-03

    An electrolyte includes a polar aprotic solvent; an alkali metal salt; and an electrode stabilizing compound that is a monomer, which when polymerized forms an electrically conductive polymer. The electrode stabilizing compound is a thiophene, a imidazole, a anilines, a benzene, a azulene, a carbazole, or a thiol. Electrochemical devices may incorporate such electrolytes.

  6. Homological stabilizer codes

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Jonas T., E-mail: jonastyleranderson@gmail.com

    2013-03-15

    In this paper we define homological stabilizer codes on qubits which encompass codes such as Kitaev's toric code and the topological color codes. These codes are defined solely by the graphs they reside on. This feature allows us to use properties of topological graph theory to determine the graphs which are suitable as homological stabilizer codes. We then show that all toric codes are equivalent to homological stabilizer codes on 4-valent graphs. We show that the topological color codes and toric codes correspond to two distinct classes of graphs. We define the notion of label set equivalencies and show that under a small set of constraints the only homological stabilizer codes without local logical operators are equivalent to Kitaev's toric code or to the topological color codes. - Highlights: Black-Right-Pointing-Pointer We show that Kitaev's toric codes are equivalent to homological stabilizer codes on 4-valent graphs. Black-Right-Pointing-Pointer We show that toric codes and color codes correspond to homological stabilizer codes on distinct graphs. Black-Right-Pointing-Pointer We find and classify all 2D homological stabilizer codes. Black-Right-Pointing-Pointer We find optimal codes among the homological stabilizer codes.

  7. Stabilized radiographic scanning agent

    International Nuclear Information System (INIS)

    Fawzi, M.B.

    1979-01-01

    A stable composition useful in preparation of technetium-99m-based radiographic scanning agents has been developed. The composition contains a stabilizing amount of gentisate stabilizer selected from gentisic acid and its soluble pharmaceutically-acceptable salts and esthers. (E.G.)

  8. Problems support economic stability

    OpenAIRE

    Tkach, Ivan

    2012-01-01

    . The article is devoted to summarizing the approaches to the classification of the stability of the state's economy, identifying the main characteristics, and offers the author's vision for the classification of the stability of the economy of the state under various conditions of operation.

  9. Stability of multihypernuclear objects

    International Nuclear Information System (INIS)

    Ikram, M.; Rather, Asloob A.; Usmani, A.A.; Patra, S.K.

    2016-01-01

    In present work, we analyze the stability of multi-hypernuclear objects having higher content of strangeness. The aim of this work is to test the stability of such objects which might be produced in heavy-ion reactions. Studies of such type of systems might have great implication to nuclear-astrophysics

  10. Conformational stability of calreticulin

    DEFF Research Database (Denmark)

    Jørgensen, C.S.; Trandum, C.; Larsen, N.

    2005-01-01

    The conformational stability of calreticulin was investigated. Apparent unfolding temperatures (T-m) increased from 31 degrees C at pH 5 to 51 degrees C at pH 9, but electrophoretic analysis revealed that calreticulin oligomerized instead of unfolding. Structural analyses showed that the single C......-terminal a-helix was of major importance to the conformational stability of calreticulin....

  11. Stability of Organic Nanowires

    DEFF Research Database (Denmark)

    Balzer, F.; Schiek, M.; Wallmann, I.

    2011-01-01

    The morphological stability of organic nanowires over time and under thermal load is of major importance for their use in any device. In this study the growth and stability of organic nanowires from a naphthyl end-capped thiophene grown by organic molecular beam deposition is investigated via ato...

  12. The statistical stability phenomenon

    CERN Document Server

    Gorban, Igor I

    2017-01-01

    This monograph investigates violations of statistical stability of physical events, variables, and processes and develops a new physical-mathematical theory taking into consideration such violations – the theory of hyper-random phenomena. There are five parts. The first describes the phenomenon of statistical stability and its features, and develops methods for detecting violations of statistical stability, in particular when data is limited. The second part presents several examples of real processes of different physical nature and demonstrates the violation of statistical stability over broad observation intervals. The third part outlines the mathematical foundations of the theory of hyper-random phenomena, while the fourth develops the foundations of the mathematical analysis of divergent and many-valued functions. The fifth part contains theoretical and experimental studies of statistical laws where there is violation of statistical stability. The monograph should be of particular interest to engineers...

  13. [Rare location of arachnoid cysts. Extratemporal cysts].

    Science.gov (United States)

    Martinez-Perez, Rafael; Hinojosa, José; Pascual, Beatriz; Panaderos, Teresa; Welter, Diego; Muñoz, María J

    2016-01-01

    The therapeutic management of arachnoid cysts depends largely on its location. Almost 50% of arachnoid cysts are located in the temporal fossa-Sylvian fissure, whereas the other half is distributed in different locations, sometimes exceptional. Under the name of infrequent location arachnoid cysts, a description is presented of those composed of 2 sheets of arachnoid membrane, which are not located in the temporal fossa, and are primary or congenital. Copyright © 2015 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  14. Goodbye Columbo, hallo cyber cops....

    CSIR Research Space (South Africa)

    Pretoria News

    2008-08-27

    Full Text Available The head of the CSIR safety and security competency area, Dr Barend Taute, says that about 10 years ago the CSIR considered what could be done about crime in South Africa. They established a crime prevention centre which eventually became the Safety...

  15. COP18 Public Agenda - ENG

    International Development Research Centre (IDRC) Digital Library (Canada)

    Hayley Price

    2012-12-02

    Dec 2, 2012 ... goal is to increase the resilience of vulnerable populations and their livelihoods in one of the following climate change “hot spots” in Africa and Asia: densely populated river basins, large deltas, and semi-arid regions. Why attend this meeting? Highly interactive sessions with a mix of research and policy ...

  16. COP 18 CARIAA Program presentation

    International Development Research Centre (IDRC) Digital Library (Canada)

    Blane Harvey

    knowledge. Promote research uptake. Strengthen adaptation expertise. Our overarching aim: To develop robust evidence on how to increase the resilience of ... www.idrc.ca/cariaa. • cariaa@idrc.ca. Speak with us. • Isabelle Proulx. • Evans Kituyi. • Michele Leone. • K.S. Murali. • Blane Harvey. • Hayley Price. • Ken De ...

  17. Perspectival Structure and Agentive Self-location

    DEFF Research Database (Denmark)

    Alsmith, Adrian

    2017-01-01

    -locating, in the sense that an episode of perceptual experience may be sufficient for thoughts about one’s location. In this chapter, I argue that perceptual experience can conceivably be perspectivally structured without locating its subject and that any account of spatial self-consciousness based upon a simple......Perceptual experience is perspectivally structured, in at least two respects. It has characteristic sensory limitations relative to a given location (limitation-structure) and it presents objects as spatially related to a given location (egocentric-structure). Perceptual experience is also self...... inference from the perspectival structure of perceptual experience faces serious difficulties. If this is correct, then we ought to look beyond the perspectival structure of perceptual experience in order to account for its self-locating content. The Agentive Self-Location Thesis, as developed here...

  18. Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

    International Nuclear Information System (INIS)

    Rockel, Beate; Schmaler, Tilo; Huang, Xiaohua; Dubiel, Wolfgang

    2014-01-01

    Highlights: • Deneddylation rates of human erythrocyte and mouse fibroblast CSN are very similar. • 3D models of native human and mouse CSN reveal common architectures. • The cryo-structure of native mammalian CSN shows a horseshoe subunit arrangement. - Abstract: The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcription factors and DNA damage response proteins. The CSN possesses structural similarities with the 26S proteasome Lid complex and the translation initiation complex 3 (eIF3) indicating similar ancestry and function. Initial structures were obtained 14 years ago by 2D electron microscopy (EM). Recently, first 3D molecular models of the CSN were created on the basis of negative-stain EM and single-particle analysis, mostly with recombinant complexes. Here, we compare deneddylating activity and structural features of CSN complexes purified in an elaborate procedure from human erythrocytes and efficiently pulled down from mouse Flag-CSN2 B8 fibroblasts. In an in vitro deneddylation assay both the human and the mouse CSN complexes deneddylated Nedd8-Cul1 with comparable rates. 3D structural models of the erythrocyte CSN as well as of the mouse Flag-CSN were generated by negative stain EM and by cryo-EM. Both complexes show a central U-shaped segment from which several arms emanate. This structure, called the horseshoe, is formed by the PCI domain subunits. CSN5 and CSN6 point away from the horseshoe. Compared to 3D models of negatively stained CSN complexes, densities assigned to CSN2 and CSN4 are better defined in the cryo-map. Because biochemical and structural results obtained with CSN complexes isolated from human erythrocytes and purified by Flag-CSN pulldown from mouse B8 fibroblasts

  19. Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

    Energy Technology Data Exchange (ETDEWEB)

    Rockel, Beate [Department of Molecular Structural Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried (Germany); Schmaler, Tilo; Huang, Xiaohua [Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin (Germany); Dubiel, Wolfgang, E-mail: Wolfgang.dubiel@charite.de [Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin (Germany)

    2014-07-25

    Highlights: • Deneddylation rates of human erythrocyte and mouse fibroblast CSN are very similar. • 3D models of native human and mouse CSN reveal common architectures. • The cryo-structure of native mammalian CSN shows a horseshoe subunit arrangement. - Abstract: The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcription factors and DNA damage response proteins. The CSN possesses structural similarities with the 26S proteasome Lid complex and the translation initiation complex 3 (eIF3) indicating similar ancestry and function. Initial structures were obtained 14 years ago by 2D electron microscopy (EM). Recently, first 3D molecular models of the CSN were created on the basis of negative-stain EM and single-particle analysis, mostly with recombinant complexes. Here, we compare deneddylating activity and structural features of CSN complexes purified in an elaborate procedure from human erythrocytes and efficiently pulled down from mouse Flag-CSN2 B8 fibroblasts. In an in vitro deneddylation assay both the human and the mouse CSN complexes deneddylated Nedd8-Cul1 with comparable rates. 3D structural models of the erythrocyte CSN as well as of the mouse Flag-CSN were generated by negative stain EM and by cryo-EM. Both complexes show a central U-shaped segment from which several arms emanate. This structure, called the horseshoe, is formed by the PCI domain subunits. CSN5 and CSN6 point away from the horseshoe. Compared to 3D models of negatively stained CSN complexes, densities assigned to CSN2 and CSN4 are better defined in the cryo-map. Because biochemical and structural results obtained with CSN complexes isolated from human erythrocytes and purified by Flag-CSN pulldown from mouse B8 fibroblasts

  20. Riqueza y abundancia de aves en bosques ribereños de diferentes anchos en la microcuenca del río Sesesmiles, Copán, Honduras

    Directory of Open Access Journals (Sweden)

    Inty T Arcos

    2008-03-01

    Full Text Available El estudió se realizó en la microcuenca del río Sesesmiles, Departamento de Copán, Honduras. El propósito fue explorar el efecto del ancho de franja de los bosques ribereños sobre la riqueza y abundancia de especies de aves que visitan estos bosques. Se encontraron 1 294 aves pertenecientes a 145 especies en bosques ribereños. La diversidad de aves estuvo ligada al ancho de franja de los bosques ribereños: se encontró mayor número de especies e individuos, en anchos iguales o mayores a 50 m. Las especies pertenecientes al grupo alimenticio de los insectívoros y nectarívoros fueron las más abundantes en las franjas ribereñas. Todas las especies de aves identificadas dependen de los bosques ribereños y responden al ancho del bosque; aún las especies más generalistas tienen algún grado de dependencia a las franjas ribereñas más anchas. Para conservar las poblaciones de aves en los paisajes agrícolas fragmentados es de suma importancia mantener franjas ribereñas que sean mayores a 50 m de ancho y que brinden suficientes habitas y recursos.Richness and abundance of birds in riparian forest belts of varied breadths at the Sesesmiles river microwatershed, Copan, Honduras. Riparian forests protect many species of plants and animals. We studied bird communities in riparian forest belts of the Sesesmiles river microwatershed, Copan, Honduras (140o 43’ 12" - 140o 58’ 35" N, 88o 53’ 23" - 89o 14’ 17" W. The main goal was to explore the effects of belt breadth on the richness and abundance of avian species visiting these forests. We selected 20 belts, and randomly established 30 observation points to monitor bird presence in the dry (March-April 2005 and rainy (June-July 2005 season (N= 60 observations. A total of 1 294 birds belonging to 145 species were recorded. Bird diversity was significantly correlated to the breadth of the riparian belts, with a greater number of species and individuals in belts 50 m wide or wider

  1. The XMM Cluster Outskirts Project (X-COP): Thermodynamic properties of the intracluster medium out to R200 in Abell 2319

    Science.gov (United States)

    Ghirardini, V.; Ettori, S.; Eckert, D.; Molendi, S.; Gastaldello, F.; Pointecouteau, E.; Hurier, G.; Bourdin, H.

    2018-06-01

    Aims: We present the joint analysis of the X-ray and Sunyaev-Zel'dovich (SZ) signals in Abell 2319, the galaxy cluster with the highest signal-to-noise ratio in SZ Planck maps and that has been surveyed within our XMM-Newton Cluster Outskirts Project (X-COP), a very large program which aims to grasp the physical condition in 12 local (z 3 × 1014 M⊙) galaxy clusters out to R200 and beyond. Methods: We recover the profiles of the thermodynamic properties by the geometrical deprojection of the X-ray surface brightness, of the SZ Comptonization parameter, and accurate and robust spectroscopic measurements of the gas temperature out to 3.2 Mpc (1.6 R200), 4 Mpc (2 R200), and 1.6 Mpc (0.8 R200), respectively. We resolve the clumpiness of the gas density to be below 20% over the entire observed volume. We also demonstrate that most of this clumpiness originates from the ongoing merger and can be associated with large-scale inhomogeneities (the "residual" clumpiness). We estimate the total mass through the hydrostatic equilibrium equation. This analysis is done both in azimuthally averaged radial bins and in eight independent angular sectors, enabling us to study in detail the azimuthal variance of the recovered properties. Results: Given the exquisite quality of the X-ray and SZ datasets, their radial extension, and their complementarity, we constrain at R200 the total hydrostatic mass, modelled with a Navarro-Frenk-White profile at very high precision (M200 = 10.7 ± 0.5stat. ± 0.9syst. × 1014 M⊙). We identify the ongoing merger and how it is affecting differently the gas properties in the resolved azimuthal sectors. We have several indications that the merger has injected a high level of non-thermal pressure in this system: the clumping free density profile is above the average profile obtained by stacking Rosat/PSPC observations; the gas mass fraction recovered using our hydrostatic mass profile exceeds the expected cosmic gas fraction beyond R500; the pressure

  2. Cops, Computers and the Right to Privacy in the Information Age: unauthorised access and inapropriate disclosure of information complaints in New South Wales

    Directory of Open Access Journals (Sweden)

    Mike Enders

    2001-05-01

    Full Text Available The term the 'information age' is particularly applicable to Australia. In a recent email, the Australian Institute of Criminology's Chief Librarian, John Myrtle, passed on statistics which showed that internet use and access in Australia has increased about 50% during the last year (Pers. Comm. 14 July 1999. Of greater interest is the fact that almost 20% of Australian households, 1.3 million, have internet access and over one third of the adult population has accessed the internet at some time during the year ending February 1999. To further back these figures, the Sydney Morning Herald of 12 February, 2000, carried statistics from the Australian Bureau of Statistics which showed that 22.6% of Australian families had home internet access (Anon., 2000a, p. 105. These figures firmly place Australians among the world's most computer literate societies. Of course computers weren't always that popular. The authors of this paper entered law enforcement at a time when computers were owned by Universities and major corporations - not individuals - and a decent calculator cost about a week's wages. However, things changed quickly and by the 1980s computers were an established part of policing. Today, all major police services are committed to, and reliant on, some form of computerised information system. The two systems which the authors have had contact with are the Crime Reporting and Information System for Police (CRISP (Queensland Police Service and the Computerised Operational Policing System (COPS (New South Wales Police Service. While many aspects of these two systems are different, they, and all the other police information systems in existence, share one major similarity: they store and provide access to personal and confidential information on every individual with whom police come into contact during their duties. Modern police investigation techniques rely on officers being able to access this information routinely to carry out their duties

  3. Booklet for sub-national stakeholders heading towards the COP 21. Agricultural and forestry focus. Key concepts on the impacts of climate change, climate policies and economic tools: insight from French territories

    International Nuclear Information System (INIS)

    Depoues, Vivian; Leseur, Alexia; Bordier, Cecile; Foucherot, Claudine; Lacan, Lea; Planton, Serge; Blanchard, Michele; Lemonsu, Aude; Martin, Eric; Masson, Valery; Soubeyroux, Jean-Michel; Ouzeau, Gaelle; Dandin, Philippe; Pigeon, Gregoire; Duvernoy, Jerome; Mondon, Sylvain; Bodiguel, Aude; Gouthiere, Laurence; Martin-Phipps, Cecile; Archambault, Sabrina; Joubert, Marion; Madariaga, Nicole; Coste, Marie-Alexandra; Viguie, Vincent; Avner, Paolo; Cassen, Christophe; Guivarch, Celine; Salagnac, Jean-Luc; Carrega, Marie; Menager, Yann

    2015-11-01

    This report, released in the year of the Paris Climate 2015 summit (COP21), reviews concepts vital for understanding and acting to address climate change at a regional level. Based on the experience of French territories it presents 37 fact-sheets aimed at local players, providing concise and informative access to the most up-to-date knowledge. It also offers feedback on the impacts of climate change, climate policies at a global, European and French level, and economic tools supporting climate change mitigation and adaptation

  4. Copepod parasites of Curimatella lepidura (Characiformes, Curimatidae from the Três Marias Reservoir, Brazil Copépodes parasitos de Curimatella lepidura (Characiformes, Curimatidae do reservatório de Três Marias, Brasil

    Directory of Open Access Journals (Sweden)

    M.C. Albuquerque

    2008-10-01

    Full Text Available Copépodes ergasilídeos coletados nas brânquias de Curimatella lepidura do reservatório de Três Marias, alto rio São Francisco, Minas Gerais, Brasil e identificados como Miracetyma etimaruya e Ergasilus sp., constituem o primeiro registro de parasitos nesse peixe forrageiro e endêmico. A ocorrência foi independente do sexo e do tamanho dos peixes. A distribuição geográfica conhecida das espécies de Miracetyma Malta, 1993, restrita à bacia do rio Amazonas, é ampliada neste estudo para a bacia do rio São Francisco.

  5. Village Stability Operations and the Afghan Local Police

    Science.gov (United States)

    2014-10-01

    Afghans who had witnessed massive ethnic slaughter during the Taliban era and now had doubts about future U.S. commitments. A lesser amount of logistical...International Studies, March 2007, http://www.csis.org, 36-37; Andrew Wilder, “ Cops or Robbers? The Struggle to Reform the Afghan National Police...Afghanistan Research and Evaluation Unit, July 2007, http:// areu.org.af/Uploads/EditionPdfs/717E- Cops %20or%20Robbers-IP-print.pdf. 9. Robert Hulslander

  6. Relations between postural stability, gait and falls in elderly persons--preliminary report.

    Science.gov (United States)

    Baczkowicz, Dawid; Szczegielniak, Jan; Proszkowiec, Małgorzata

    2008-01-01

    Balance control in elderly patients is the area of interest of many researchers. The results of their studies suggest that the measurement of shifts in the centre of foot pressure on the support base (COP) can be used as a tool for identification of fall-prone persons. It is interesting whether there are any relations between functional status, gait, posture stability and the risk of falling. The aim of this study was to find the answer to this question. The study involved 20 patients (mean age 78.1+/-11.6). The functional status of the patients was evaluated according to the Barthel Index. Postural stability was assessed with the use of a Neurocom Balance Master platform. Three measurements were taken with visual feedback (eyes open-EO) and three without visual feedback (eyes closed-EC). Balance control was also evaluated with the Berg test and on the basis of the history of episodes of falling in the preceding six months. Gait was evaluated with the six-minute walking test. The parameters recorded by the force platform showed a significant relation to the values obtained in the Berg test (r=-0.60; pfalls showed a significant relation only to the EO test (r=0.4; pfalls was connected with increased body sway. 3. The functional status of the patient and the balance control evaluation according to the Berg test failed to determine the risk of falling. 4. A relation was observed between postural stability, functional status and gait.

  7. Dispersal and metapopulation stability

    Directory of Open Access Journals (Sweden)

    Shaopeng Wang

    2015-10-01

    Full Text Available Metapopulation dynamics are jointly regulated by local and spatial factors. These factors may affect the dynamics of local populations and of the entire metapopulation differently. Previous studies have shown that dispersal can stabilize local populations; however, as dispersal also tends to increase spatial synchrony, its net effect on metapopulation stability has been controversial. Here we present a simple metapopulation model to study how dispersal, in interaction with other spatial and local processes, affects the temporal variability of metapopulations in a stochastic environment. Our results show that in homogeneous metapopulations, the local stabilizing and spatial synchronizing effects of dispersal cancel each other out, such that dispersal has no effect on metapopulation variability. This result is robust to moderate heterogeneities in local and spatial parameters. When local and spatial dynamics exhibit high heterogeneities, however, dispersal can either stabilize or destabilize metapopulation dynamics through various mechanisms. Our findings have important theoretical and practical implications. We show that dispersal functions as a form of spatial intraspecific mutualism in metapopulation dynamics and that its effect on metapopulation stability is opposite to that of interspecific competition on local community stability. Our results also suggest that conservation corridors should be designed with appreciation of spatial heterogeneities in population dynamics in order to maximize metapopulation stability.

  8. Life raft stabilizer

    Science.gov (United States)

    Radnofsky, M. I.; Barnett, J. H., Jr.; Harrison, F. L.; Marak, R. J. (Inventor)

    1973-01-01

    An improved life raft stabilizer for reducing rocking and substantially precluding capsizing is discussed. The stabilizer may be removably attached to the raft and is defined by flexible side walls which extend a considerable depth downwardly to one another in the water. The side walls, in conjunction with the floor of the raft, form a ballast enclosure. A weight is placed in the bottom of the enclosure and water port means are provided in the walls. Placement of the stabilizer in the water allows the weighted bottom to sink, producing submerged deployment thereof and permitting water to enter the enclosure through the port means, thus forming a ballast for the raft.

  9. Gravity stabilizes itself

    International Nuclear Information System (INIS)

    Chakraborty, Sumanta; SenGupta, Soumitra

    2017-01-01

    We show that a possible resolution to the stabilization of an extra spatial dimension (radion) can be obtained solely in the context of gravitational dynamics itself without the necessity of introducing any external stabilizing field. In this scenario the stabilized value of the radion field gets determined in terms of the parameters appearing in the higher curvature gravitational action. Furthermore, the mass of the radion field and its coupling to the standard model fields are found to be in the weak scale implying possible signatures in the TeV scale colliders. Some resulting implications are also discussed. (orig.)

  10. Gravity stabilizes itself

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, Sumanta; SenGupta, Soumitra [Indian Association for the Cultivation of Science, Department of Theoretical Physics, Kolkata (India)

    2017-08-15

    We show that a possible resolution to the stabilization of an extra spatial dimension (radion) can be obtained solely in the context of gravitational dynamics itself without the necessity of introducing any external stabilizing field. In this scenario the stabilized value of the radion field gets determined in terms of the parameters appearing in the higher curvature gravitational action. Furthermore, the mass of the radion field and its coupling to the standard model fields are found to be in the weak scale implying possible signatures in the TeV scale colliders. Some resulting implications are also discussed. (orig.)

  11. Stability analysis of maize hybrids across north west of Pakistan

    International Nuclear Information System (INIS)

    Rahman, H.; Durreshawar; Ali, S.; Iftikhar, F.; Khalil, I.H.; Shah, S.M.A.; Ahmad, H.

    2010-01-01

    Stability analysis was carried out to study stability in performance and genotype x environment interactions for 18 maize hybrids across three locations of NWFP i.e., Agricultural University Peshawar (AUP), Agricultural Research Station (ARS), Baffa, (Mansehra) and Cereal Crops Research Institute (CCRI), Pirsabak (Nowshera), during 2006. Data were recorded on different morphological and yield parameters. Analysis of variance indicated significant differences among the three locations for all the traits studied. Hybrids showed significant differences for all parameters except anthesis silking interval (ASI) and ear height, which were non significant across the three locations. The hybrid x location interactions also revealed significant differences for days to 50% silking, days to 50% anthesis, ASI, grain moisture at harvest and grain yield per hectare while non significant differences were observed for plant height and ear height. Based on yield performance of hybrids across the three locations, Baffa ranked first as compared to the other two locations. Hybrid DK-1 x EV-9806 was the highest yielding across the three locations followed by hybrid AGB-108, while the lowest yield was observed for hybrid CSCY. Stability in performance was evident for hybrid CS-2Y2 with regard to days required for silking and anthesis. Stability in anthesis silking interval (ASI) was manifested for hybrid CS-222. Hybrid AGB-108 was comparatively stable for grain yield across the tested locations. Remaining hybrids seemed to be considerably influenced by Genotype x environment interactions encountered at the tested locations and location specific selection has to be made while selecting a maize hybrid for a particular location. (author)

  12. Compact fiber optic gyroscopes for platform stabilization

    Science.gov (United States)

    Dickson, William C.; Yee, Ting K.; Coward, James F.; McClaren, Andrew; Pechner, David A.

    2013-09-01

    SA Photonics has developed a family of compact Fiber Optic Gyroscopes (FOGs) for platform stabilization applications. The use of short fiber coils enables the high update rates required for stabilization applications but presents challenges to maintain high performance. We are able to match the performance of much larger FOGs by utilizing several innovative technologies. These technologies include source noise reduction to minimize Angular Random Walk (ARW), advanced digital signal processing that minimizes bias drift at high update rates, and advanced passive thermal packaging that minimizes temperature induced bias drift while not significantly affecting size, weight, or power. In addition, SA Photonics has developed unique distributed FOG packaging technologies allowing the FOG electronics and photonics to be packaged remotely from the sensor head or independent axis heads to minimize size, weight, and power at the sensing location(s). The use of these technologies has resulted in high performance, including ARW less than 0.001 deg/rt-hr and bias drift less than 0.004 deg/hr at an update rate of 10 kHz, and total packaged volume less than 30 cu. in. for a 6 degree of freedom FOG-based IMU. Specific applications include optical beam stabilization for LIDAR and LADAR, beam stabilization for long-range free-space optical communication, Optical Inertial Reference Units for HEL stabilization, and Ka band antenna pedestal pointing and stabilization. The high performance of our FOGs also enables their use in traditional navigation and positioning applications. This paper will review the technologies enabling our high-performance compact FOGs, and will provide performance test results.

  13. Indoor Positioning with Radio Location Fingerprinting

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun

    . A promising indoor positioning technique is radio-based location ngerprinting, having the major advantage of exploiting already existing radio infrastructures, like IEEE 802.11 or GSM, which avoids extra deployment costs and eort. The research goal of this thesis is to address the limitations of current...... indoor location ngerprinting systems. In particular the aim is to advance location ngerprinting techniques for the challenges of handling heterogeneous clients, scalability to many clients, and interference between communication and positioning. The wireless clients used for location ngerprinting...... are heterogeneous even when only considering clients for the same technology. The heterogeneity is due to dierent radios, antennas, and rmwares causing measurements for location ngerprinting not to be directly comparable among clients. Heterogeneity is a challenge for location ngerprinting because it severely...

  14. Finding dense locations in indoor tracking data

    DEFF Research Database (Denmark)

    Ahmed, Tanvir; Pedersen, Torben Bach; Lu, Hua

    2014-01-01

    for semi-constrained indoor movement, and then uses this to map raw tracking records into mapping records representing object entry and exit times in particular locations. Then, an efficient indexing structure, the Dense Location Time Index (DLT-Index) is proposed for indexing the time intervals...... of the mapping table, along with associated construction, query processing, and pruning techniques. The DLT-Index supports very efficient aggregate point queries, interval queries, and dense location queries. A comprehensive experimental study with real data shows that the proposed techniques can efficiently......Finding the dense locations in large indoor spaces is very useful for getting overloaded locations, security, crowd management, indoor navigation, and guidance. Indoor tracking data can be very large and are not readily available for finding dense locations. This paper presents a graph-based model...

  15. Allocation and Location of Transport Logistics Centres

    Directory of Open Access Journals (Sweden)

    D. Mocková

    2010-01-01

    Full Text Available The facility allocation problem sets out to determine the optimal number of facilities to be opened. Based on multiple criteria evaluation, the optimal location of the facilities is usually solved subsequently. Several considerations, e.g. technical parameters, costs and finance must be taken into account. Economic analysis is carried out on the basis of the specific instance of the problem.Let us assume that the number of potentially located facilities is known. Then the problem of the optimal location of a given number of facilities in a network is referred to as the facility location problem. The solution to the problem is a set of facilities optimally located in an area such that this area is fully covered by the required services that the facilities provide. An example of a real-life problem of this type is the location of logistics centers. 

  16. Analysis on soil compressibility changes of samples stabilized with lime

    Directory of Open Access Journals (Sweden)

    Elena-Andreea CALARASU

    2016-12-01

    Full Text Available In order to manage and control the stability of buildings located on difficult foundation soils, several techniques of soil stabilization were developed and applied worldwide. Taking into account the major significance of soil compressibility on construction durability and safety, the soil stabilization with a binder like lime is considered one of the most used and traditional methods. The present paper aims to assess the effect of lime content on soil geotechnical parameters, especially on compressibility ones, based on laboratory experimental tests, for several soil categories in admixture with different lime dosages. The results of this study indicate a significant improvement of stabilized soil parameters, such as compressibility and plasticity, in comparison with natural samples. The effect of lime stabilization is related to an increase of soil structure stability by increasing the bearing capacity.

  17. Network location theory and contingency planning

    Energy Technology Data Exchange (ETDEWEB)

    Hakimi, S L

    1983-08-01

    A brief survey of results in network location theory is first presented. Then, a systems view of contingency planning is described. Finally, some results in location theory are re-examined and it is shown that they are motivated by contingency planning considerations. Some new issues and problems in location theory are described, which, if properly tackled, will have a substantial impact on contingency planning in transportation.

  18. Stability of matter

    International Nuclear Information System (INIS)

    Thirring, W.

    1985-01-01

    Basing on quantum mechanics and the simple Hamiltonian consisting of kinetic energy and Coulomb potential, heuristic arguments and estimates are used to guess the essential stability properties of many-particle systems. In view of applications in astrophysics, gravitation as a second potential and thermodynamic arguments are added. The guesses thus obtained are confronted with known exact results. The connection between the stabilities against explosion and against implosion, and thermodynamic stability is considered. In systems with a particle number larger than approx= 10 54 (corresponding to the Jupiter mass) gravitational energy prevails over the electrostatic energy and determines the history of a star. Negative specific heat accompanies life and death of a star. Finally the role of stability and instability in the universe for life is outlined. (G.Q.)

  19. Progress on plutonium stabilization

    International Nuclear Information System (INIS)

    Hurt, D.

    1996-01-01

    The Defense Nuclear Facilities Safety Board has safety oversight responsibility for most of the facilities where unstable forms of plutonium are being processed and packaged for interim storage. The Board has issued recommendations on plutonium stabilization and has has a considerable influence on DOE's stabilization schedules and priorities. The Board has not made any recommendations on long-term plutonium disposition, although it may get more involved in the future if DOE develops plans to use defense nuclear facilities for disposition activities

  20. Structural Stability and Vibration

    DEFF Research Database (Denmark)

    Wiggers, Sine Leergaard; Pedersen, Pauli

    This book offers an integrated introduction to the topic of stability and vibration. Strikingly, it describes stability as a function of boundary conditions and eigenfrequency as a function of both boundary conditions and column force. Based on a post graduate course held by the author at the Uni...... and their derivation, thus stimulating them to write interactive and dynamic programs to analyze instability and vibrational modes....

  1. Automatic Fiscal Stabilizers

    Directory of Open Access Journals (Sweden)

    Narcis Eduard Mitu

    2013-11-01

    Full Text Available Policies or institutions (built into an economic system that automatically tend to dampen economic cycle fluctuations in income, employment, etc., without direct government intervention. For example, in boom times, progressive income tax automatically reduces money supply as incomes and spendings rise. Similarly, in recessionary times, payment of unemployment benefits injects more money in the system and stimulates demand. Also called automatic stabilizers or built-in stabilizers.

  2. Soil stabilization 1982

    Science.gov (United States)

    Barenberg, E. J.; Thompson, M. R.; Tayabji, S. D.; Nussbaum, P. J.; Ciolko, A. T.

    Seven papers cover the following areas: design, construction and performance of lime, fly ash, and slag pavement; evaluation of heavily loaded cement stabilized bases; coal refuse and fly ash compositions; potential highway base course materials; lime soil mixture design considerations for soils of southeastern United States; short term active soil property changes caused by injection of lime and fly ash; soil cement for use in stream channel grade stabilization structures; and reaction products of lime treated southeastern soils.

  3. Investigations of slope stability

    Energy Technology Data Exchange (ETDEWEB)

    Nonveiller, E.

    1979-01-01

    The dynamics of slope slides and parameters for calculating slope stability is discussed. Two types of slides are outlined: rotation slide and translation slide. Slide dynamics are analyzed according to A. Heim. A calculation example of a slide which occurred at Vajont, Yugoslavia is presented. Calculation results differ from those presented by Ciabatti. For investigation of slope stability the calculation methods of A.W. Bishop (1955), N. Morgenstern and M. Maksimovic are discussed. 12 references

  4. PFP solution stabilization

    International Nuclear Information System (INIS)

    Aftanas, B.L.

    1996-01-01

    This Functional Design Criteria (FDC) addresses remediation of the plutonium-bearing solutions currently in inventory at the Plutonium Finishing Plant (PFP). The recommendation from the Environmental Impact Statement (EIS) is that the solutions be treated thermally and stabilized as a solid for long term storage. For solutions which are not discardable, the baseline plan is to utilize a denitration process to stabilize the solutions prior to packaging for storage

  5. METHOD FOR STABILIZING KLYSTRONS

    Science.gov (United States)

    Magnuson, D.W.; Smith, D.F.

    1959-04-14

    High-frequency oscillators for the generation of microwaves, particularly a system for stabilizing frequency-modulated klystron oscillators of the reflex type, are described. The system takos advantage of the fact that a change in oscillator frequency will alter the normal phase displacement between the cavity and its modulator, creating an error voltage which is utilized to regulate the frequency of the oscillator and stabilize it.

  6. Locating techniques for nuclear power stations

    International Nuclear Information System (INIS)

    Hayashi, Masao

    1983-01-01

    The basic thought in locating nuclear power stations is to examine carefully the suitability of sites and the safety of plants, and in the end, to perfect the safety of public. In Japan, effort is exerted to obtain the trust of local people by carrying out investigation, research and examination from respective standpoints of the government, institutes and industries. The author has engaged in the standardization of the investigation, test and analysis regarding the aseismatic capability of ground, the verifying project in Tadotsu of the coupled vibration of ground and structures, the evaluation of the performance of large vibration tables, the future concept of new locating procedure and so on in the last more than ten years. The technological classification of ground, the technological meaning of active faults, the procedure of the aseismatic design of plants, the difference of earthquake input force according to various locating methods, 12 rules regarding the attenuation of vibration of ground, and the concept of new locating method in the 21st century are explained. As the new locating techniques applicable to central Japan, diluvial ground location, floating location in tunnels, underground location, offshore location and so on must be promoted. (Kako, I.)

  7. Location-dependent communications using quantum entanglement

    International Nuclear Information System (INIS)

    Malaney, Robert A.

    2010-01-01

    The ability to unconditionally verify the location of a communication receiver would lead to a wide range of new security paradigms. However, it is known that unconditional location verification in classical communication systems is impossible. In this work we show how unconditional location verification can be achieved with the use of quantum communication channels. Our verification remains unconditional irrespective of the number of receivers, computational capacity, or any other physical resource held by an adversary. Quantum location verification represents an application of quantum entanglement that delivers a feat not possible in the classical-only channel. It gives us the ability to deliver real-time communications viable only at specified geographical coordinates.

  8. Semantic Location Extraction from Crowdsourced Data

    Science.gov (United States)

    Koswatte, S.; Mcdougall, K.; Liu, X.

    2016-06-01

    Crowdsourced Data (CSD) has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network). This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  9. SEMANTIC LOCATION EXTRACTION FROM CROWDSOURCED DATA

    Directory of Open Access Journals (Sweden)

    S. Koswatte

    2016-06-01

    Full Text Available Crowdsourced Data (CSD has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network. This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  10. Overdenture locator attachments for atrophic mandible

    Directory of Open Access Journals (Sweden)

    Neerja Mahajan

    2013-01-01

    Full Text Available Implant-supported overdentures provide a good opportunity for dentists to improve oral health and quality-of-life of patients. Atrophic mandible poses a significant challenge to successful oral rehabilitation with dental implants. In this article, the fabrication of lower overdenture by two narrow platform implants is described with dual retentive, resilient, self-locating locator attachment system. The locator attachment system has the lowest profile in comparison with the ball and bar attachments and is versatile up to 40΀ of divergence between two implants. By using locators as attachments, we can meet functional, economic and social expectation of patients with ease and satisfaction.

  11. Cyber Deterrence and Stability

    Energy Technology Data Exchange (ETDEWEB)

    Goychayev, Rustam [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carr, Geoffrey A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weise, Rachel A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Donnelly, David A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Clements, Samuel L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Benz, Jacob M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rodda, Kabrena E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bartholomew, Rachel A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McKinnon, Archibald D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Andres, Richard B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-09-30

    Throughout the 20th and early 21st centuries, deterrence and arms control have been cornerstones of strategic stability between the superpowers. However, the weaponization of the cyber realm by State actors and the multipolar nature of cyber conflict now undermines that stability. Strategic stability is the state in which nations believe that if they act aggressively to undermine U.S. national interests and the post-World War II liberal democratic order, the consequences will outweigh the benefits. The sense of lawlessness and lack of consequences in the cyber realm embolden States to be more aggressive in taking actions that undermine stability. Accordingly, this paper examines 1) the role of deterrence and arms control in securing cyber stability, and 2) the limitations and challenges associated with these traditional national security paradigms as applied to this emerging threat domain. This paper demonstrates that many 20th-century deterrence and arms control concepts are not particularly applicable in the cyber realm. However, they are not entirely irrelevant. The United States can distill lessons learned from this rich deterrence and arms control experience to develop and deploy a strategy to advance cyber stability.

  12. Location, Location, Location.

    Science.gov (United States)

    Finucan, Karen

    2000-01-01

    Discusses how good schools have drawing power in revitalizing both urban and rural communities and increasing property values. Several examples of the value of school renovation and its impact on the surrounding community and enrollment are discussed, including descriptions of planning and financing renovation efforts by some communities. (GR)

  13. Location, Location, Location

    Science.gov (United States)

    Cates, Deborah; Gutiérrez, Eva; Hafer, Sarah; Barrett, Ryan; Corina, David

    2013-01-01

    This article presents an analysis of the relationship between sign structure and iconicity in American Sign Language. Historically, linguists have been pressured to downplay the role of form-meaning relationships (iconicity) in signed languages. However, recent inquiries into the role of traditional phonological parameters of signs (handshape,…

  14. Location, Location, Location

    CERN Multimedia

    Clery, Daniel

    2007-01-01

    "When nations vie for massive international scientific facilities, science can take a back seat to politics and even sheer chance. Dealmakers say there's no magic formula for getting things right." (3 pages)

  15. Location, location, location

    CERN Multimedia

    Clery, Daniel

    2007-01-01

    "When nations vie for massive international scientific facilities, science can take a back seat to politics and even sheer chance. Dealmakers say there's no magic formula for getting things right." (4,5 pages)

  16. Harmonic disturbance location by applying Bayesian inference

    NARCIS (Netherlands)

    Ye, G.; Xiang, Y.; Cuk, V.; Cobben, J.F.G.

    2016-01-01

    Harmonic pollution is one of the most important power quality issues in electric power systems. Correct location of the main harmonic disturbance source is a key step to solve the problem. This paper presents a method to detect the location of harmonic disturbance source in low voltage network

  17. 46 CFR 72.10-10 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Location. 72.10-10 Section 72.10-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Means of Escape § 72.10-10 Location. (a) The two means of escape shall be as remote as practicable so as to minimize...

  18. 22 CFR 1300.6 - Office location.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Office location. 1300.6 Section 1300.6 Foreign Relations MILLENNIUM CHALLENGE CORPORATION ORGANIZATION AND FUNCTIONS OF THE MILLENNIUM CHALLENGE CORPORATION § 1300.6 Office location. The principal offices of the Millennium Challenge Corporation are...

  19. 39 CFR 962.7 - Hearing location.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Hearing location. 962.7 Section 962.7 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE PROGRAM FRAUD CIVIL REMEDIES ACT § 962.7 Hearing location. An oral hearing under this part shall be held (a) In...

  20. 46 CFR 111.40-7 - Location.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Location. 111.40-7 Section 111.40-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Panelboards § 111.40-7 Location. Each panelboard must be accessible but not in a bunker or a cargo hold...