WorldWideScience

Sample records for stability testing protocol

  1. Consensus stability testing protocols for organic photovoltaic materials and devices

    DEFF Research Database (Denmark)

    Reese, Matthew O.; Gevorgyan, Suren; Jørgensen, Mikkel

    2011-01-01

    Procedures for testing organic solar cell devices and modules with respect to stability and operational lifetime are described. The descriptions represent a consensus of the discussion and conclusions reached during the first 3 years of the international summit on OPV stability (ISOS). The proced...

  2. Use of a quality-by-design approach to justify removal of the HPLC weight % assay from routine API stability testing protocols.

    Science.gov (United States)

    Skrdla, Peter J; Wang, Tao; Antonucci, Vincent; Dowling, Thomas; Ge, Zhihong; Ellison, Dean; Curran, John; Mohan, Ganapathy; Wyvratt, Jean

    2009-12-05

    Due to the high method variability (typically > or = 0.5%, based on a literature survey and internal Merck experience) encountered in the HPLC weight percent (%) assays of various active pharmaceutical ingredients (APIs), it is proposed that the routine use of the test in stability studies should be discouraged on the basis that it is frequently not sufficiently precise to yield results that are stability-indicating. The high method variability of HPLC weight % methods is not consistent with the current ICH practice of reporting impurities/degradation products down to the 0.05% level, and it can lead to erroneous out-of-specification (OOS) results that are due to experimental error and are not attributable to API degradation. For the vast majority of cases, the HPLC impurity profile provides much better (earlier and more sensitive) detection of low-level degradation products. Based on these observations, a Quality-by-Design (QbD) approach is proposed to phase out the HPLC weight % assay from routine API stability testing protocols.

  3. Contribution of a muscle fatigue protocol to a dynamic stability screening test for exertional medial tibial pain.

    Science.gov (United States)

    Verrelst, Ruth; De Clercq, Dirk; Willems, Tine Marieke; Victor, Jan; Witvrouw, Erik

    2014-05-01

    muscle fatigue protocol to the single-legged drop jump as a screening test for EMTP risk factors may enhance the possibility of identifying the leg at risk in a predisposed athlete and might determine the proximal risk factors for that leg at risk more thoroughly.

  4. Exploiting symmetry in protocol testing

    NARCIS (Netherlands)

    J.M.T. Romijn (Judi); J.G. Springintveld

    1999-01-01

    textabstractTest generation and execution are often hampered by the large state spaces of the systems involved. In automata (or transition system) based test algorithms, taking advantage of symmetry in the behavior of specification and implementation may substantially reduce the amount of tests. We

  5. Sludge stabilization operability test report

    International Nuclear Information System (INIS)

    Lewis, W.S.

    1994-01-01

    Document provides the results of the Operability Test Procedure performed to test the operability of the HC-21C thermal stabilization process for sludge. The OTP assured all equipment functioned properly and established the baseline temperature profile for glovebox HC-21C

  6. Protocol, pattern and paper: interactive stabilization of immunohistochemical knowledge.

    Science.gov (United States)

    Nederbragt, Hubertus

    2010-12-01

    This paper analyzes the investigation of the distribution of the protein tenascin-C in canine mammary tumors. The method involved immunohistochemistry of tissue slices, performed by the application of an antibody to tenascin-C that specifically can be made visible for microscopic inspection. The first phase of the project is the making of the protocol, the second the deduction of a pattern of tenascin-C distribution in tumors and the third the writing of a paper. Each of the phases is analyzed separately, using the concept of resistance and accommodation. My purpose is to show that in each phase of the process of producing knowledge, the scientist meets resistances which force him to accommodate by changing his conceptual, technical and methodological approaches. In reverse, the details of the non-human agent (protocol, pattern or paper) have to be accommodated to the wishes and expectations of the scientist. Through this interaction a situation of stability of knowledge is reached at the end of each phase. In the protocol phase, resistance is found in the antibody and tissue slices. In the phase of pattern deduction the resistance is in the pathological diagnosis of the tumors and the expectations and hypothesis with which the scientist had entered the project; in the criteria to be used for assigning the slices to a tenascin-C pattern; and in the responses of colleagues and supervisor. In the paper-writing phase the interaction is between the scientist and the scientific community which should take on board the knowledge from the research project. When stabilization of knowledge is obtained in one of the phases, the agents of resistance turn into allies in the next phase, giving support to accommodating the resistances in this later phase. Second, the stabilization of knowledge of the protocol is further enhanced when stabilization of the pattern is achieved; in addition, knowledge of the pattern is more definite when it has become stabilized and closed knowledge

  7. Byzantine-fault tolerant self-stabilizing protocol for distributed clock synchronization systems

    Science.gov (United States)

    Malekpour, Mahyar R. (Inventor)

    2010-01-01

    A rapid Byzantine self-stabilizing clock synchronization protocol that self-stabilizes from any state, tolerates bursts of transient failures, and deterministically converges within a linear convergence time with respect to the self-stabilization period. Upon self-stabilization, all good clocks proceed synchronously. The Byzantine self-stabilizing clock synchronization protocol does not rely on any assumptions about the initial state of the clocks. Furthermore, there is neither a central clock nor an externally generated pulse system. The protocol converges deterministically, is scalable, and self-stabilizes in a short amount of time. The convergence time is linear with respect to the self-stabilization period.

  8. Conversion of a general quantum stabilizer code to an entanglement distillation protocol

    International Nuclear Information System (INIS)

    Matsumoto, Ryutaroh

    2003-01-01

    We show how to convert a quantum stabilizer code to a one- or two-way entanglement distillation protocol. The proposed conversion method is a generalization of those of Shor-Preskill and Nielsen-Chuang. The recurrence protocol and the quantum privacy amplification protocol are equivalent to the protocols converted from [[2, 1

  9. GENERIC VERIFICATION PROTOCOL: DISTRIBUTED GENERATION AND COMBINED HEAT AND POWER FIELD TESTING PROTOCOL

    Science.gov (United States)

    This report is a generic verification protocol by which EPA’s Environmental Technology Verification program tests newly developed equipment for distributed generation of electric power, usually micro-turbine generators and internal combustion engine generators. The protocol will ...

  10. A Model Based Security Testing Method for Protocol Implementation

    Directory of Open Access Journals (Sweden)

    Yu Long Fu

    2014-01-01

    Full Text Available The security of protocol implementation is important and hard to be verified. Since the penetration testing is usually based on the experience of the security tester and the specific protocol specifications, a formal and automatic verification method is always required. In this paper, we propose an extended model of IOLTS to describe the legal roles and intruders of security protocol implementations, and then combine them together to generate the suitable test cases to verify the security of protocol implementation.

  11. 21 CFR 211.166 - Stability testing.

    Science.gov (United States)

    2010-04-01

    ... expiration dates provided full shelf life studies are not available and are being conducted. Where data from... shelf life studies, there must be stability studies conducted, including drug product testing at... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Stability testing. 211.166 Section 211.166 Food...

  12. Formulation and stability testing of photolabile drugs.

    Science.gov (United States)

    Tønnesen, H H

    2001-08-28

    Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs.

  13. Formal Test Automation: The Conference Protocol with PHACT

    NARCIS (Netherlands)

    Heerink, A.W.; Ural, Hasan; Probert, Robert L.; Feenstra, J.; Tretmans, G.J.; von Bochmann, Gregor

    2000-01-01

    We discuss a case study of automatic test generation and test execution based on formal methods. The case is the Conference Protocol, a simple, chatbox-like protocol, for which (formal) specifications and multiple implementations are publicly available and which is also used in other case study

  14. A chronic toxicity test protocol using Caridina nilotica (Decapoda ...

    African Journals Online (AJOL)

    Salinization of freshwater resources is an increasing global problem, yet there is a paucity of chronic salinity tolerance data linked to very few chronic toxicity test protocols. This research aimed to generate a chronic toxicity test protocol and protective salinity tolerance data for the indigenous South African freshwater shrimp ...

  15. Terrestrial Photovoltaic Module Accelerated Test-To-Failure Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C. R.

    2008-03-01

    This technical report documents a test-to-failure protocol that may be used to obtain quantitative information about the reliability of photovoltaic modules using accelerated testing in environmental temperature-humidity chambers.

  16. On the Stability of Communication Systems with Timed Token Protocols

    NARCIS (Netherlands)

    Blanc, J.P.C.

    1999-01-01

    Medium Access Control protocols for high speed LAN/MANs often employ a timer-controlled token passing mechanism to control station access to the shared media. These protocols support time-critical (real-time) applications, and provide priority among non time-critical applications. This paper

  17. Formal Test Automation: The Conference Protocol with PHACT

    OpenAIRE

    Heerink, A.W.; Ural, Hasan; Probert, Robert L.; Feenstra, J.; Tretmans, G.J.; von Bochmann, Gregor

    2000-01-01

    We discuss a case study of automatic test generation and test execution based on formal methods. The case is the Conference Protocol, a simple, chatbox-like protocol, for which (formal) specifications and multiple implementations are publicly available and which is also used in other case study experiments. The tool used for test generation and test execution is Phact, the PHilips Automated Conformance Tester. The formal method is (Extented) Finite State Machines which is the input language f...

  18. Automation for a base station stability testing

    OpenAIRE

    Punnek, Elvis

    2016-01-01

    This Batchelor’s thesis was commissioned by Oy LM Ericsson Ab Oulu. The aim of it was to help to investigate and create a test automation solution for the stability testing of the LTE base station. The main objective was to create a test automation for a predefined test set. This test automation solution had to be created for specific environments and equipment. This work included creating the automation for the test cases and putting them to daily test automation jobs. The key factor...

  19. 16 CFR 1210.4 - Test protocol.

    Science.gov (United States)

    2010-01-01

    .... Subtract the child's birth date from the test date. Month Day Year Test Date 8 3 94 Birth Date 6 23 90... their confidence. (2) The tester shall tell the children that he or she needs their help for a special... actual testing is videotaped, the camera shall be stationary and shall be operated remotely in order to...

  20. Accurate Stabilities of Laccase Mutants Predicted with a Modified FoldX Protocol

    DEFF Research Database (Denmark)

    Christensen, Niels Johan; Kepp, Kasper Planeta

    2012-01-01

    Fungal laccases are multi-copper enzymes of industrial importance due to their high stability, multi-functionality, and oxidizing power. This paper reports computational protocols that quantify the relative stability (∆∆G of folding) of mutants of high-redox-potential laccases (TvLIIIb and PM1L...

  1. Water-Dispersible Polyurethane Coating Test Protocol

    National Research Council Canada - National Science Library

    Miller, Christopher

    1999-01-01

    ...) formulation that is also a chemical agent resistant coating (CARC). This report describes the substrates, pretreatments, and primers to be used in comparative testing of the new formulation vs. current CARC...

  2. 16 CFR 1212.4 - Test protocol.

    Science.gov (United States)

    2010-01-01

    ... participating, and shall not be told that the test is a game or contest or that it is fun. (3) The tester shall... operate it. (This interaction is not considered to be disruption as described in paragraph (e)(2) of this..., photograph(s) or video tape to show how the multi-purpose lighter was held in the tester's hand, and the...

  3. A Passive Testing Approach for Protocols in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Xiaoping Che

    2015-11-01

    Full Text Available Smart systems are today increasingly developed with the number of wireless sensor devices drastically increasing. They are implemented within several contexts throughout our environment. Thus, sensed data transported in ubiquitous systems are important, and the way to carry them must be efficient and reliable. For that purpose, several routing protocols have been proposed for wireless sensor networks (WSN. However, one stage that is often neglected before their deployment is the conformance testing process, a crucial and challenging step. Compared to active testing techniques commonly used in wired networks, passive approaches are more suitable to the WSN environment. While some works propose to specify the protocol with state models or to analyze them with simulators and emulators, we here propose a logic-based approach for formally specifying some functional requirements of a novel WSN routing protocol. We provide an algorithm to evaluate these properties on collected protocol execution traces. Further, we demonstrate the efficiency and suitability of our approach by its application into common WSN functional properties, as well as specific ones designed from our own routing protocol. We provide relevant testing verdicts through a real indoor testbed and the implementation of our protocol. Furthermore, the flexibility, genericity and practicability of our approach have been proven by the experimental results.

  4. A Passive Testing Approach for Protocols in Wireless Sensor Networks

    Science.gov (United States)

    Che, Xiaoping; Maag, Stephane; Tan, Hwee-Xian; Tan, Hwee-Pink; Zhou, Zhangbing

    2015-01-01

    Smart systems are today increasingly developed with the number of wireless sensor devices drastically increasing. They are implemented within several contexts throughout our environment. Thus, sensed data transported in ubiquitous systems are important, and the way to carry them must be efficient and reliable. For that purpose, several routing protocols have been proposed for wireless sensor networks (WSN). However, one stage that is often neglected before their deployment is the conformance testing process, a crucial and challenging step. Compared to active testing techniques commonly used in wired networks, passive approaches are more suitable to the WSN environment. While some works propose to specify the protocol with state models or to analyze them with simulators and emulators, we here propose a logic-based approach for formally specifying some functional requirements of a novel WSN routing protocol. We provide an algorithm to evaluate these properties on collected protocol execution traces. Further, we demonstrate the efficiency and suitability of our approach by its application into common WSN functional properties, as well as specific ones designed from our own routing protocol. We provide relevant testing verdicts through a real indoor testbed and the implementation of our protocol. Furthermore, the flexibility, genericity and practicability of our approach have been proven by the experimental results. PMID:26610495

  5. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L. [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-01

    Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project team collected field data on 11 houses in 2015.

  6. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-05

    "9Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project provides several key results. State weatherization agencies do not generally track combustion safety failures, the data from those that do suggest that there is little actual evidence that combustion safety failures due to spillage from non-dryer exhaust are common and that only a very small number of homes are subject to the failures. The project team collected field data on 11 houses in 2015. Of these homes, two houses that demonstrated prolonged and excessive spillage were also the only two with venting systems out of compliance with the National Fuel Gas Code. The remaining homes experienced spillage that only occasionally extended beyond the first minute of operation. Combustion zone depressurization, outdoor temperature, and operation of individual fans all provide statistically significant predictors of spillage.

  7. Test Bench Development for Femur Stability Assessment

    Directory of Open Access Journals (Sweden)

    Samuel SANCHEZ-CABALLERO

    2015-01-01

    Full Text Available This paper shows the design and development of a test bench for humanfemurs. The main uses of this test bench will run from artificial femurs comparisonwith real femurs, to join stability assessment after bone a fracture repair. Amongthis uses is specially designed for condylar fractures testing. The test bench isdeveloped from a self-made existing tensile/compression testing machine. Thedesign procedure is supported by a literature review about the bone mechanicalbehavior and composition generally and the knee joint performance and repairparticularly. On the basis of this review, the machine was designed to simulate theadduction and abduction movements of the joint. The magnitudes to be measuredare: the compression force, the bone displacement (vertical and the knee jointrotation

  8. Evaluation of a cognitive rehabilitation protocol in HIV patients with associated neurocognitive disorders: efficacy and stability over time

    Directory of Open Access Journals (Sweden)

    Alessandro eLivelli

    2015-11-01

    Full Text Available The primary aim of the present study was to evaluate the efficacy and stability over time of a cognitive rehabilitation protocol (restorative and compensatory approach in HIV/AIDS patients with HIV-associated Neurocognitive Disorder (HAND. At baseline, thirty-two HIV/AIDS patients (sixteen with and sixteen without HAND were assessed with a neuropsychological battery (i.e., pre-assessment consisting of twenty-two tests covering eight cognitive domains. Then, the experimental group was administered over four months a cognitive rehabilitation protocol aimed at improving four cognitive domains by means of eight paper and pencil/computer-based exercises. The control group received guideline-adherent clinical care (i.e., standard of care. At the end of the cognitive treatment, both groups were re-administered the neuropsychological battery (i.e., post-assessment. Additionally, six months after post-assessment, the experimental group was given the same neuropsychological battery (i.e., follow up-assessment. In order to test the efficacy of the cognitive rehabilitation protocol, we compared between groups the results of the neuropsychological battery at the pre- and post- assessments. In order to evaluate the stability over time, the effects of the cognitive rehabilitation protocol was examined comparing within the experimental group the results of the neuropsychological battery at post- and follow up-assessments. Our results show that the two groups did not differ at the pre-assessment, but differed at post- assessment. Specifically, the experimental group showed a significant improvement in five domains (Learning & memory, Abstraction/executive functioning, Verbal fluency, Attention/working memory and Functional, whereas the control group significantly worsened in the same domains. The improvement of the experimental group did not change in the follow up-assessment in two domains (Abstraction/executive functioning, Attention/working memory and

  9. Testing protocols for evaluating monolithic waste forms containing mixed wastes

    International Nuclear Information System (INIS)

    Gilliam, T.M.; Sams, T.L.; Pitt, W.W.

    1986-01-01

    Test protocols have been presented which can be used as a guide in cement-based grout formulation development studies. Based on experience at ORNL, these six tests are generally sufficient to develop a grout product which will meet all applicable DOE, NRC, and EPA performance criteria. As such, these tests can be used to minimize the time required to tailor a grout to be compatible with both the waste stream and the process disposal scenario. 9 refs

  10. Testing heated flint palaeodose protocols using dose recovery procedures

    International Nuclear Information System (INIS)

    Richter, D.; Temming, H.

    2006-01-01

    Thermoluminescence (TL) dating of materials from archaeological contexts has been shown to be an accurate method when comparisons are made with other chronometric dating methods; however, little has been published on the verification of the measurement protocols used to determine the equivalent dose (palaeodose). Instead of testing TL dating protocols for heated flint using archaeological material with unknown thermal and radiation history, dose recovery tests for three samples of different geological origin are presented. These samples exhibit TL emission in the UV, blue and orange-red wavelengths. In addition to the two multiple aliquot protocols (standard additive-regeneration and normalization) generally used to determine the palaeodose, the single-aliquot-regenerative-dose (SAR) TL and OSL procedure, a 'short' SAR-TL and isothermal luminescence (IT) decay procedures are applied using detection windows limited to these emissions. Accurate dose recovery is obtained for the standard and normalization protocols in the commonly employed detection window (UV-blue), the 'short' SAR in the orange-red window and some IT measurements. While the standard techniques give the most accurate and precise results, detection of the TL and IT orange-red emission in connection with a 'short' SAR protocol also gave accurate and precise results. Such procedures are especially suitable for samples too small for standard multiple aliquot techniques, which require large samples

  11. Laboratory protocols for testing the efficacy of commercial pit latrine ...

    African Journals Online (AJOL)

    additive products. Protocols were developed and tested on a range of different commercial products sold for their ability to control the rate of accumulation of pit latrine contents. The effect of commercial additives on mass loss from VIP sludge in. 300 g honey jars was compared to mass loss from similar units subjected to no ...

  12. Anaerobic exercise testing in rehabilitation : A systematic review of available tests and protocols

    NARCIS (Netherlands)

    Krops, Leonie A.; Albada, Trijntje; van der Woude, Lucas H. V.; Hijmans, Juha M.; Dekker, Rienk

    Objective: Anaerobic capacity assessment in rehabilitation has received increasing scientific attention in recent years. However, anaerobic capacity is not tested consistently in clinical rehabilitation practice. This study reviews tests and protocols for anaerobic capacity in adults with various

  13. Stability comparison of two different dentoalveolar expansion treatment protocols

    Directory of Open Access Journals (Sweden)

    Ezgi Atik

    Full Text Available ABSTRACT Objective: The aim of this study was to compare the longitudinal stability of the conventional straight-wire system after the use of a quad-helix appliance with Damon self-ligating system in patients with Class I malocclusion. Methods: 27 adolescent patients were evaluated at three different periods: pre-treatment (T1, post-treatment (T2 and three years post-treatment (T3. Group 1 included 12 patients (with a mean age of 14.65 year treated with Damon 3MX bracket system; and Group 2 included 15 patients (with a mean age of 14.8 year who underwent orthodontic treatment with Roth prescribed brackets after expansion with Quad-Helix appliance. Relapse was evaluated with dental cast examination and cephalometric radiograph tracings. Statistical analysis was performed with IBM-SPSS for Windows software, version 21 (SPSS Inc., Chicago, IL. A p-value smaller than 0.05 was considered statistically significant. Results: There were significant increases in all transverse dental and postero-anterior measurements (except for UL6-ML mm in Group 1 with active treatment. There was some significant relapse in the long-term in inter-canine width in both groups and in the inter-first premolar width in Group 2 (p< 0.05. Significant decrease in all frontal measurements from T2 to T3 was seen for both groups. Upper and lower incisors significantly proclined in T1-T2 (p<0.05, however no relapse was found for both groups. When two systems were compared, there was no significant difference for the long-term follow-up period. Conclusion: Conventional (quad-helix appliance with conventional brackets and Damon systems were found similar with regard to the long-term incisor positions and transverse dimension changes of maxillary arch.

  14. Quench detection electronics testing protocol for SST-1 magnets

    International Nuclear Information System (INIS)

    Banaudha, Moni; Varmora, Pankaj; Parghi, Bhadresh; Prasad, Upendra

    2017-01-01

    Quench Detection (QD) system consisting 204 signal channels has been successfully installed and working well during plasma experiment of SST-1 Tokamak. QD system requires testing, validation and maintenance in every SST-1 campaign for better reliability and maintainability of the system. Standalone test of each channel of the system is essential for hard-ware validation. The standard Testing Protocol follow in every campaign which validate each section of QD electronics as well as voltage tap signal cables which are routed inside the cryostat and then extended outside of the SST-1 machine up-to the magnet control room. Fiber link for Quench signal transmission to the SST-1 magnet power supply is also test and validate before every plasma campaign. Precise instrument used as a dummy source of quench signal and for manual quench generation to test the each channel and Master Quench Logic. Each signal Integrated with the magnet DAQ system, signal observed at 1Hz and 50Hz configuration to validate the logging data, compare with actual and previous test data. This paper describes the testing protocol follow in every campaign to validate functionality of QD electronics, limitation of testing, test results and overall integration of the quench detection system for SST-1 magnet. (author)

  15. Test Protocols for Advanced Inverter Interoperability Functions – Main Document

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ralph, Mark E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Distributed energy resources (DER) such as photovoltaic (PV) systems, when deployed in a large scale, are capable of influencing significantly the operation of power systems. Looking to the future, stakeholders are working on standards to make it possible to manage the potentially complex interactions between DER and the power system. In 2009, the Electric Power Research Institute (EPRI), Sandia National Laboratories (SNL) with the U.S. Department of Energy (DOE), and the Solar Electric Power Association (SEPA) initiated a large industry collaborative to identify and standardize definitions for a set of DER grid support functions. While the initial effort concentrated on grid-tied PV inverters and energy storage systems, the concepts have applicability to all DER. A partial product of this on-going effort is a reference definitions document (IEC TR 61850-90-7, Object models for power converters in distributed energy resources (DER) systems) that has become a basis for expansion of related International Electrotechnical Commission (IEC) standards, and is supported by US National Institute of Standards and Technology (NIST) Smart Grid Interoperability Panel (SGIP). Some industry-led organizations advancing communications protocols have also embraced this work. As standards continue to evolve, it is necessary to develop test protocols to independently verify that the inverters are properly executing the advanced functions. Interoperability is assured by establishing common definitions for the functions and a method to test compliance with operational requirements. This document describes test protocols developed by SNL to evaluate the electrical performance and operational capabilities of PV inverters and energy storage, as described in IEC TR 61850-90-7. While many of these functions are not currently required by existing grid codes or may not be widely available commercially, the industry is rapidly moving in that direction. Interoperability issues are already

  16. Test Protocols for Advanced Inverter Interoperability Functions - Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ralph, Mark E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Broderick, Robert Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Distributed energy resources (DER) such as photovoltaic (PV) systems, when deployed in a large scale, are capable of influencing significantly the operation of power systems. Looking to the future, stakeholders are working on standards to make it possible to manage the potentially complex interactions between DER and the power system. In 2009, the Electric Power Research Institute (EPRI), Sandia National Laboratories (SNL) with the U.S. Department of Energy (DOE), and the Solar Electric Power Association (SEPA) initiated a large industry collaborative to identify and standardize definitions for a set of DER grid support functions. While the initial effort concentrated on grid-tied PV inverters and energy storage systems, the concepts have applicability to all DER. A partial product of this on-going effort is a reference definitions document (IEC TR 61850-90-7, Object models for power converters in distributed energy resources (DER) systems) that has become a basis for expansion of related International Electrotechnical Commission (IEC) standards, and is supported by US National Institute of Standards and Technology (NIST) Smart Grid Interoperability Panel (SGIP). Some industry-led organizations advancing communications protocols have also embraced this work. As standards continue to evolve, it is necessary to develop test protocols to independently verify that the inverters are properly executing the advanced functions. Interoperability is assured by establishing common definitions for the functions and a method to test compliance with operational requirements. This document describes test protocols developed by SNL to evaluate the electrical performance and operational capabilities of PV inverters and energy storage, as described in IEC TR 61850-90-7. While many of these functions are not now required by existing grid codes or may not be widely available commercially, the industry is rapidly moving in that direction. Interoperability issues are already apparent as

  17. Surface stabilization and revegetation test plots

    International Nuclear Information System (INIS)

    Sackschewsky, M.R.; Kemp, C.J.; Hayward, W.M.

    1993-09-01

    Westinghouse Hanford Company Decommissioning and Decontamination Engineering Group and Environmental Technology and Assessment Groups are developing new technologies to improve revegetation techniques for interim stabilization control over underground waste sites within the Radiation Area Remedial Action Program. Successful revegetation is an integral aspect of waste isolation strategy. Unfortunately, revegetation can be very difficult to achieve on the Hanford Site due to several factors: low annual precipitation, unpredictable timing of precipitation, low fertility of available soils, and coarse physical texture of soils covering waste sites. The tests in this report were performed during fiscal years 1992 and 1993 and include the use of two soil sealants in combination with bare soil and a soil/compost mixture and a comparison of a wheatgrass mixture and a native seed mixture. Hydroprobe access ports were placed in one-half of the test plots and moisture data was collected. Soil fertility and plant community characteristics were monitored during the two years of the test. During the first year all sites with compost provided additional fertility and retained greater amounts of soil moisture than noncomposted sites. The use of Enduraseal soil fixative provided greater soil moisture than the use of Aerospray-77 soil fixative. During the second year the use of compost and soil fixative's had a lesser effect on soil moisture. During late summer periods all treatments had very similar soil moisture profiles. The use of compost greatly increased vegetative cover and soil fertility in comparison to sites that had no compost added. Testing of the seed mixtures found that Siberian wheatgrass and Sandberg's bluegrass were the most dominant of the seeded species observed. All plots exhibited a dominant plant cover of volunteer cheatgrass. Biomass production was significantly greater on plots with compost than on the noncomposted plots

  18. Core stability: inter- and intraobserver reliability of 6 clinical tests

    NARCIS (Netherlands)

    Weir, Adam; Darby, Jennifer; Inklaar, Han; Koes, Bart; Bakker, Erik; Tol, Johannes L.

    2010-01-01

    Core stability is a complex concept within sports medicine and is thought to play a role in sports injuries. There is a lack of reliable and valid clinical tests for core stability. The inter- and intraobserver reliability of 6 tests commonly used to assess core stability was determined. A video of

  19. Development of Standardized Material Testing Protocols for Prosthetic Liners.

    Science.gov (United States)

    Cagle, John C; Reinhall, Per G; Hafner, Brian J; Sanders, Joan E

    2017-04-01

    A set of protocols was created to characterize prosthetic liners across six clinically relevant material properties. Properties included compressive elasticity, shear elasticity, tensile elasticity, volumetric elasticity, coefficient of friction (CoF), and thermal conductivity. Eighteen prosthetic liners representing the diverse range of commercial products were evaluated to create test procedures that maximized repeatability, minimized error, and provided clinically meaningful results. Shear and tensile elasticity test designs were augmented with finite element analysis (FEA) to optimize specimen geometries. Results showed that because of the wide range of available liner products, the compressive elasticity and tensile elasticity tests required two test maxima; samples were tested until they met either a strain-based or a stress-based maximum, whichever was reached first. The shear and tensile elasticity tests required that no cyclic conditioning be conducted because of limited endurance of the mounting adhesive with some liner materials. The coefficient of friction test was based on dynamic coefficient of friction, as it proved to be a more reliable measurement than static coefficient of friction. The volumetric elasticity test required that air be released beneath samples in the test chamber before testing. The thermal conductivity test best reflected the clinical environment when thermal grease was omitted and when liner samples were placed under pressure consistent with load bearing conditions. The developed procedures provide a standardized approach for evaluating liner products in the prosthetics industry. Test results can be used to improve clinical selection of liners for individual patients and guide development of new liner products.

  20. Functional Testing Protocols for Commercial Building Efficiency Baseline Modeling Software

    Energy Technology Data Exchange (ETDEWEB)

    Jump, David; Price, Phillip N.; Granderson, Jessica; Sohn, Michael

    2013-09-06

    This document describes procedures for testing and validating proprietary baseline energy modeling software accuracy in predicting energy use over the period of interest, such as a month or a year. The procedures are designed according to the methodology used for public domain baselining software in another LBNL report that was (like the present report) prepared for Pacific Gas and Electric Company: ?Commercial Building Energy Baseline Modeling Software: Performance Metrics and Method Testing with Open Source Models and Implications for Proprietary Software Testing Protocols? (referred to here as the ?Model Analysis Report?). The test procedure focuses on the quality of the software?s predictions rather than on the specific algorithms used to predict energy use. In this way the software vendor is not required to divulge or share proprietary information about how their software works, while enabling stakeholders to assess its performance.

  1. Self-testing protocols based on the chained Bell inequalities

    International Nuclear Information System (INIS)

    Šupić, I; Augusiak, R; Salavrakos, A; Acín, A

    2016-01-01

    Self-testing is a device-independent technique based on non-local correlations whose aim is to certify the effective uniqueness of the quantum state and measurements needed to produce these correlations. It is known that the maximal violation of some Bell inequalities suffices for this purpose. However, most of the existing self-testing protocols for two devices exploit the well-known Clauser–Horne–Shimony–Holt Bell inequality or modifications of it, and always with two measurements per party. Here, we generalize the previous results by demonstrating that one can construct self-testing protocols based on the chained Bell inequalities, defined for two devices implementing an arbitrary number of two-output measurements. On the one hand, this proves that the quantum state and measurements leading to the maximal violation of the chained Bell inequality are unique. On the other hand, in the limit of a large number of measurements, our approach allows one to self-test the entire plane of measurements spanned by the Pauli matrices X and Z. Our results also imply that the chained Bell inequalities can be used to certify two bits of perfect randomness. (paper)

  2. Mobility test protocols for the elderly: a methodological note

    Directory of Open Access Journals (Sweden)

    Nejc Sarabon

    2015-09-01

    Full Text Available Consequences of falls are a major health problem in elderly. Poor balance is the precursor of falls and balance impairment has been evidenced after an injury. On the other hand, balance and stability can be improved with training. At the beginning of the project Mobility in Aging one of the questions was how to measure dynamic and static balance in order to get reliable and sensitive parameters to follow the effect of decay in movement functions in elderly or to track the improvement after training. In this short report we will give a couple of answers to a long standing debate. There is indeed evidence in literature that stability and balance is very important. Elderly people often shift from the so called ankle strategy to the hip strategy for balancing. The reflex reactions are the more to decay and we observed more co-contractions. Also, inactivity causes slower muscles contractions. Our goal should be a combination of trainings, where we can see changes at neuromuscular, structural and molecular levels, but we would like to say that our training protocols did not touch all the aspects of movement function we aimed to observe. Future projects will hopefully provide the missing information.

  3. Uncertainty considerations for interferometric stability testing

    NARCIS (Netherlands)

    Ellis, J.D.; Joo, K.N.; Verlaan, A.L.; Spronck, J.W.

    2008-01-01

    Material stability is an important parameter for EUV lithography, space instrumentation, and metrology in general. In both EUV lithography and space, more information is needed about material stability during an atmospheric to vacuum transition. For metrology instruments in general, determining the

  4. A new testing protocol for zirconia dental implants.

    Science.gov (United States)

    Sanon, Clarisse; Chevalier, Jérôme; Douillard, Thierry; Cattani-Lorente, Maria; Scherrer, Susanne S; Gremillard, Laurent

    2015-01-01

    Based on the current lack of standards concerning zirconia dental implants, we aim at developing a protocol to validate their functionality and safety prior their clinical use. The protocol is designed to account for the specific brittle nature of ceramics and the specific behavior of zirconia in terms of phase transformation. Several types of zirconia dental implants with different surface textures (porous, alveolar, rough) were assessed. The implants were first characterized in their as-received state by Scanning Electron Microscopy (SEM), Focused Ion Beam (FIB), X-Ray Diffraction (XRD). Fracture tests following a method adapted from ISO 14801 were conducted to evaluate their initial mechanical properties. Accelerated aging was performed on the implants, and XRD monoclinic content measured directly at their surface instead of using polished samples as in ISO 13356. The implants were then characterized again after aging. Implants with an alveolar surface presented large defects. The protocol shows that such defects compromise the long-term mechanical properties. Implants with a porous surface exhibited sufficient strength but a significant sensitivity to aging. Even if associated to micro cracking clearly observed by FIB, aging did not decrease mechanical strength of the implants. As each dental implant company has its own process, all zirconia implants may behave differently, even if the starting powder is the same. Especially, surface modifications have a large influence on strength and aging resistance, which is not taken into account by the current standards. Protocols adapted from this work could be useful. Copyright © 2014 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  5. Quantitative sensory testing using DFNS protocol in Europe

    DEFF Research Database (Denmark)

    Vollert, Jan; Attal, Nadine; Baron, Ralf

    2016-01-01

    Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from...... patients with painful peripheral nerve injury were included in the analysis. Mixed effects models were constructed for each of the 11 normally distributed QST parameters with z-value as the dependent variable, and center as the random effect. The I statistic for heterogeneity was calculated, an index...

  6. STRESS TESTS FOR VIDEOSTREAMING SERVICES BASED ON RTSP PROTOCOL

    Directory of Open Access Journals (Sweden)

    Gabriel Elías Chanchí Golondrino

    2015-11-01

    Full Text Available Video-streaming is a technology with major implications these days in such diverse contexts as education, health and the business sector; all of this regarding the ease it provides for remote access to live or recorded media content, allowing communication regardless of geographic location. One standard protocol that enables implementation of this technology is real time streaming protocol, or RTSP. However, since most application servers and Internet services are supported on HTTP requests, very little research has been done on generating tools for carrying out stress tests on streaming servers. This paper presents a stress measuring tool called Hermes, developed in Python, which allows calculation of response times for establishing RTSP connections to streaming servers, as well as obtaining RAM memory consumption and CPU usage rate data from these servers. Hermes was deployed in a video-streaming environment where stress testing was carried out on the LIVE555 server, using calls in the background to VLC and OpenRTSP open source clients. 

  7. Audit protocol of compliance test on x-ray and interventional radiodiagnostic

    International Nuclear Information System (INIS)

    Endang Kunarsih; Fitria Sandra

    2011-01-01

    Testing protocol is a document that defined and implemented by the testing agency in conducting compliance testing to ensure that quality of testing implementation is planned and controlled in accordance with applicable regulations and standards. Testing protocol is required in filing an application to be a qualified testing agency. Auditors will review the testing protocol document to assess adequacy of the acceptance criteria before proceed to the next process. This paper presents the acceptance criteria required in an audit of the testing protocol document from the applicant of testing agency. (author)

  8. Image Registration for Stability Testing of MEMS

    Science.gov (United States)

    Memarsadeghi, Nargess; LeMoigne, Jacqueline; Blake, Peter N.; Morey, Peter A.; Landsman, Wayne B.; Chambers, Victor J.; Moseley, Samuel H.

    2011-01-01

    Image registration, or alignment of two or more images covering the same scenes or objects, is of great interest in many disciplines such as remote sensing, medical imaging. astronomy, and computer vision. In this paper, we introduce a new application of image registration algorithms. We demonstrate how through a wavelet based image registration algorithm, engineers can evaluate stability of Micro-Electro-Mechanical Systems (MEMS). In particular, we applied image registration algorithms to assess alignment stability of the MicroShutters Subsystem (MSS) of the Near Infrared Spectrograph (NIRSpec) instrument of the James Webb Space Telescope (JWST). This work introduces a new methodology for evaluating stability of MEMS devices to engineers as well as a new application of image registration algorithms to computer scientists.

  9. The validity and reliability of a dynamic neuromuscular stabilization-heel sliding test for core stability.

    Science.gov (United States)

    Cha, Young Joo; Lee, Jae Jin; Kim, Do Hyun; You, Joshua Sung H

    2017-10-23

    Core stabilization plays an important role in the regulation of postural stability. To overcome shortcomings associated with pain and severe core instability during conventional core stabilization tests, we recently developed the dynamic neuromuscular stabilization-based heel sliding (DNS-HS) test. The purpose of this study was to establish the criterion validity and test-retest reliability of the novel DNS-HS test. Twenty young adults with core instability completed both the bilateral straight leg lowering test (BSLLT) and DNS-HS test for the criterion validity study and repeated the DNS-HS test for the test-retest reliability study. Criterion validity was determined by comparing hip joint angle data that were obtained from BSLLT and DNS-HS measures. The test-retest reliability was determined by comparing hip joint angle data. Criterion validity was (ICC2,3) = 0.700 (pTest-retest reliability was (ICC3,3) = 0.953 (pvalidity data demonstrated a good relationship between the gold standard BSLLT and DNS-HS core stability measures. Test-retest reliability data suggests that DNS-HS core stability was a reliable test for core stability. Clinically, the DNS-HS test is useful to objectively quantify core instability and allow early detection and evaluation.

  10. Quality Assurance Protocol for AFCI Advanced Structural Materials Testing

    International Nuclear Information System (INIS)

    Busby, Jeremy T.

    2009-01-01

    The objective of this letter is to inform you of recent progress on the development of advanced structural materials in support of advanced fast reactors and AFCI. As you know, the alloy development effort has been initiated in recent months with the procurement of adequate quantities of the NF616 and HT-UPS alloys. As the test alloys become available in the coming days, mechanical testing, evaluation of optimizing treatments, and screening of environmental effects will be possible at a larger scale. It is therefore important to establish proper quality assurance protocols for this testing effort in a timely manner to ensure high technical quality throughout testing. A properly implemented quality assurance effort will also enable preliminary data taken in this effort to be qualified as NQA-1 during any subsequent licensing discussions for an advanced design or actual prototype. The objective of this report is to describe the quality assurance protocols that will be used for this effort. An essential first step in evaluating quality protocols is assessing the end use of the data. Currently, the advanced structural materials effort is part of a long-range, basic research and development effort and not, as yet, involved in licensing discussions for a specific reactor design. After consultation with Mark Vance (an ORNL QA expert) and based on the recently-issued AFCI QA requirements, the application of NQA-1 quality requirements will follow the guidance provided in Part IV, Subpart 4.2 of the NQA-1 standard (Guidance on Graded Application of QA for Nuclear-Related Research and Development). This guidance mandates the application of sound scientific methodology and a robust peer review process in all phases, allowing for the data to be qualified for use even if the programmatic mission changes to include licensing discussions of a specific design or prototype. ORNL has previously implemented a QA program dedicated to GNEP activities and based on an appropriately graded

  11. Quality Assurance Protocol for AFCI Advanced Structural Materials Testing

    Energy Technology Data Exchange (ETDEWEB)

    Busby, Jeremy T [ORNL

    2009-05-01

    The objective of this letter is to inform you of recent progress on the development of advanced structural materials in support of advanced fast reactors and AFCI. As you know, the alloy development effort has been initiated in recent months with the procurement of adequate quantities of the NF616 and HT-UPS alloys. As the test alloys become available in the coming days, mechanical testing, evaluation of optimizing treatments, and screening of environmental effects will be possible at a larger scale. It is therefore important to establish proper quality assurance protocols for this testing effort in a timely manner to ensure high technical quality throughout testing. A properly implemented quality assurance effort will also enable preliminary data taken in this effort to be qualified as NQA-1 during any subsequent licensing discussions for an advanced design or actual prototype. The objective of this report is to describe the quality assurance protocols that will be used for this effort. An essential first step in evaluating quality protocols is assessing the end use of the data. Currently, the advanced structural materials effort is part of a long-range, basic research and development effort and not, as yet, involved in licensing discussions for a specific reactor design. After consultation with Mark Vance (an ORNL QA expert) and based on the recently-issued AFCI QA requirements, the application of NQA-1 quality requirements will follow the guidance provided in Part IV, Subpart 4.2 of the NQA-1 standard (Guidance on Graded Application of QA for Nuclear-Related Research and Development). This guidance mandates the application of sound scientific methodology and a robust peer review process in all phases, allowing for the data to be qualified for use even if the programmatic mission changes to include licensing discussions of a specific design or prototype. ORNL has previously implemented a QA program dedicated to GNEP activities and based on an appropriately graded

  12. Stability Testing of Beclomethasone Dipropionate Nanoemulsion ...

    African Journals Online (AJOL)

    The nanoemulsions were characterized by droplet size, pH, viscosity, conductivity and refractive index. Stability studies were performed according to International Council on Harmonization (ICH) guidelines over a period of 3 months. Droplet size, pH, viscosity, conductivity and refractive index were determined monthly for 3 ...

  13. Acid Pit Stabilization Project (Volume 1 - Cold Testing) and (Volume 2 - Hot Testing)

    Energy Technology Data Exchange (ETDEWEB)

    G. G. Loomis (INEEL); A. P. Zdinak (MSE); M. A. Ewanic (MSE); J. J. Jessmore (INEEL)

    1998-01-01

    During the summer and fall of Fiscal Year 1997, a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Treatability Study was performed at the Idaho National Engineering and Environmental Laboratory. The study involved subsurface stabilization of a mixed waste contaminated soil site called the Acid Pit. This study represents the culmination of a successful technology development effort that spanned Fiscal Years 1994-1996. Research and development of the in situ grout stabilization technique was conducted. Hardware and implementation techniques are currently documented in a patent pending with the United States Patent and Trademark Office. The stabilization technique involved using jet grouting of an innovative grouting material to form a monolith out of the contamination zone. The monolith simultaneously provides a barrier to further contaminant migration and closes voids in the soil structure against further subsidence. This is accomplished by chemical incorporation of contaminants into less soluble species and achieving a general reduction in hydraulic conductivity within the monolith. The grout used for this study was TECT-HG, a relatively dense iron oxide-based cementitious grout. The treatability study involved cold testing followed by in situ stabilization of the Acid Pit. Volume 1 of this report discusses cold testing, performed as part of a ''Management Readiness Assessment'' in preparation for going hot. Volume 2 discusses the results of the hot Acid Pit Stabilization phase of this project. Drilling equipment was specifically rigged to reduce the spread of contamination, and all grouting was performed under a concrete block containing void space to absorb any grout returns. Data evaluation included examination of implementability of the grouting process and an evaluation of the contaminant spread during grouting. Following curing of the stabilized pit, cores were obtained and evaluated for toxicity

  14. Test-Retest Stability of Word Retrieval in Aphasic Discourse

    Science.gov (United States)

    Boyle, Mary

    2014-01-01

    Purpose: This study examined the test-retest stability of select word-retrieval measures in the discourses of people with aphasia who completed a 5-stimulus discourse task. Method: Discourse samples across 3 sessions from 12 individuals with aphasia were analyzed for the stability of measures of informativeness, efficiency, main concepts, noun and…

  15. Beyond the Bruce Protocol: Advanced Exercise Testing for the Sports Cardiologist.

    Science.gov (United States)

    Sarma, Satyam; Levine, Benjamin D

    2016-11-01

    Exercise testing is an important tool for determining baseline fitness as well as to diagnose limitations in performance. The Bruce protocol has become the standard for exercise testing protocol in many exercise physiology laboratories, but is rarely a suitable test for athletes who often have complex hemodynamic and metabolic demands during exercise required for practice and competition. We describe the approach for exercise testing beyond the Bruce protocol and focus on strategies to individualize the testing protocol to the metabolic demands of an athlete's sport. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Improving active Mealy machine learning for protocol conformance testing

    NARCIS (Netherlands)

    Aarts, F.; Kuppens, H.; Tretmans, J.; Vaandrager, F.; Verwer, S.

    2014-01-01

    Using a well-known industrial case study from the verification literature, the bounded retransmission protocol, we show how active learning can be used to establish the correctness of protocol implementation I relative to a given reference implementation R. Using active learning, we learn a model M

  17. Developing a dynamic virtual stimulation protocol to induce linear egomotion during orthostatic posture control test

    Directory of Open Access Journals (Sweden)

    Paulo José Guimarães Da-Silva

    Full Text Available Abstract Introduction In this work, the effect of a dynamic visual stimulation (DS protocol was used to induce egomotion, the center of pressure (COP displacement response. Methods DS was developed concerning the scenario structure (chessboard-pattern floor and furniture and luminance. To move the scenario in a discrete forward (or backward direction, the furniture is expanded (or reduced and the black and white background is reversed during floor translation while the luminance is increased (or reduced by steps of 2 cd/m2. This protocol was evaluated using COP signals from 29 healthy volunteers: standing on a force platform observing the virtual scene (1.72 × 1.16 m projected 1 m ahead (visual incidence angle: θl = 81.4° and θv = 60.2°, which moves with constant velocity (2 m/s during 250 ms. A set of 100 DS was applied in random order, interspersed by a 10 s of static scene. Results The Tukey post-hoc test (p < 0.001 indicated egomotion in the same direction of DS. COP displacement increased over stimulation (8.4 ± 1.7 to 22.6 ±5.3 mm, as well as time to recover stability (4.1 ± 0.4 to 7.2 ± 0.6 s. The peak of egomotion during DSF occurred 200 ms after DSB (Wilcoxon, p = 0.002. Conclusion The dynamic configuration of this protocol establishes virtual flow effects of linear egomotion dependent on the direction of the dynamic visual stimulation. This finding indicates the potential application of the proposed virtual dynamic stimulation protocol to investigate the cortical visual evoked response in postural control studies.

  18. Computerized method of visual acuity testing: adaptation of the amblyopia treatment study visual acuity testing protocol.

    Science.gov (United States)

    Moke, P S; Turpin, A H; Beck, R W; Holmes, J M; Repka, M X; Birch, E E; Hertle, R W; Kraker, R T; Miller, J M; Johnson, C A

    2001-12-01

    To report a computerized method for determining visual acuity in children using the Amblyopia Treatment Study visual acuity testing protocol. A computerized visual acuity tester was developed that uses a programmed handheld device that uses the Palm operating system (Palm, Inc, Santa Clara, California). The handheld device communicates with a personal computer running a Linux operating system and 17-inch monitor. At a test distance of 3 m, single letters can be displayed from 20/800 to 20/12. A C program on the handheld device runs the Amblyopia Treatment Study visual acuity testing protocol. Using this method, visual acuity was tested in both the right and left eyes, and then the testing was repeated in 156 children age 3 to 7 years at four clinical sites. Test-retest reliability was high (r =.92 and 0.95 for and right and left eyes, respectively), with 88% of right eye retests and 94% of left eye retests within 0.1 logarithm of minimal angle of resolution (logMAR) units of the initial test. The 95% confidence interval for an acuity score was calculated to be the score +/- 0.13 logMAR units. For a change between two acuity scores, the 95% confidence interval was the difference +/- 0.19 logMAR units. We have developed a computerized method for measurement of visual acuity. Automation of the Amblyopia Treatment Study visual acuity testing protocol is an effective method of testing visual acuity in children 3 to 7 years of age.

  19. Surface stability test plan for protective barriers

    International Nuclear Information System (INIS)

    Ligotke, M.W.

    1989-01-01

    Natural-material protective barriers for long-term isolation of buried waste have been identified as integral components of a plan to isolate a number of Hanford defense waste sites. Standards currently being developed for internal and external barrier performance will mandate a barrier surface layer that is resistant to the eolian erosion processes of wind erosion (deflation) and windborne particle deposition (formation of sand dunes). Thus, experiments are needed to measure rates of eolian erosion processes impacting those surfaces under different surface and climatological conditions. Data from these studies will provide information for use in the evaluation of selected surface layers as a means of providing stable cover over waste sites throughout the design life span of protective barriers. The multi-year test plan described in this plan is directed at understanding processes of wind erosion and windborne particle deposition, providing measurements of erosion rates for models, and suggesting construction materials and methods for reducing the effect of long-term eolian erosion on the barrier. Specifically, this plan describes possible methods to measure rates of eolian erosion, including field and laboratory procedure. Advantages and disadvantages of laboratory (wind tunnel) tests are discussed, and continued wind tunnel tests are recommended for wind erosion studies. A comparison between field and wind tunnel erosive forces is discussed. Plans for testing surfaces are described. Guidance is also presented for studying the processes controlling sand dune and blowout formation. 24 refs., 7 figs., 3 tabs

  20. Standardised test protocol (Constant Score) for evaluation of functionality in patients with shoulder disorders

    DEFF Research Database (Denmark)

    Ban, Ilija; Troelsen, Anders; Christiansen, David Høyrup

    2013-01-01

    physiotherapists gave feedback on the objective part. Relevant items were culturally adapted and rephrased, and a simple standardised test protocol was developed. RESULTS: Only minor inconsistencies in the translations were found. A few questions and words had to be rephrased due to cultural and linguistic...... differences. One of the authors of the modified CS approved both the English and the Danish test protocol. CONCLUSION: A simple test protocol of the modified CS was developed in both English and Danish. With precise terminology and definitions, the test protocol is the first of its kind. We suggest its use...

  1. Generator Set Environmental and Stability Testing

    Science.gov (United States)

    2015-03-01

    EOT End of Test HFRR High Frequency Reciprocating Rig HRJ-8 Hydro-Renewable Jet Fuel JFTOT Jet Fuel Thermal Oxidation Test kW kilo Watts MEP... Jet -A. The blend was additized with 22.5 ppm DCI-4A and 1 ppm STADIS to bring the blend into conformance with the MIL-DTL-83133G specification. As...Muff psia psia 13.96 1.468 Exh Cyl 3 F 751.9 1.00 Exh Cyl 4 F 763.8 0.97 Power kW 15.6 Exh Manifold F 797.6 0.63 Voltage L1 V 119.2 0.07 After Turbo

  2. Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectrometry

    OpenAIRE

    Tran, Duc T.; Banerjee, Sambuddha; Alayash, Abdu I.; Crumbliss, Alvin L.; Fitzgerald, Michael C.

    2012-01-01

    Described here is a mass spectrometry based protocol to study the thermodynamic stability of proteins and protein-ligand complexes using the slow H/D exchange reaction of the imidazole C2 proton in histidine side chains. The protocol, which involves evaluating the denaturant dependence of this slow H/D exchange reaction in proteins, allows the global and/or subglobal unfolding/refolding properties of proteins and protein-ligand complexes to be probed. The protocol is developed using several m...

  3. Authentication Test-Based the RFID Authentication Protocol with Security Analysis

    Directory of Open Access Journals (Sweden)

    Minghui Wang

    2014-08-01

    Full Text Available To the problem of many recently proposed RFID authentication protocol was soon find security holes, we analyzed the main reason, which is that protocol design is not rigorous, and the correctness of the protocol cannot be guaranteed. To this end, authentication test method was adopted in the process of the formal analysis and strict proof to the proposed RFID protocol in this paper. Authentication Test is a new type of analysis and design method of security protocols based on Strand space model, and it can be used for most types of the security protocols. After analysis the security, the proposed protocol can meet the RFID security demand: information confidentiality, data integrity and identity authentication.

  4. Testing objects in Computerized Axial Tomography. Contributions to the Spanish Protocol on quality control in radiodiagnostics

    International Nuclear Information System (INIS)

    Villaescusa, J.I.; Campayo, J.M.

    1995-01-01

    In the provisional version of the Spanish Protocol about the technical aspects of Quality Control in Radiodiagnostic,SEFM-SEPR 1993, it is dedicated a section to Computerized Axial tomography, establishing a total of eleven technical parameters of the equipment for examination. The present work describes the practical use of the Protocol using various types of Test Object. The authors also propose new tests that should be considered in the final version of the Spanish Protocol. (Author)

  5. Stability Mechanisms of Laccase Isoforms using a Modified FoldX Protocol Applicable to Widely Different Proteins

    DEFF Research Database (Denmark)

    Christensen, Niels J.; Kepp, Kasper P.

    2013-01-01

    ) and thermostability (Topt ∼ 45–80 °C) and with 67–77% sequence identity. The extended protocol uses (i) statistical averaging, (ii) a molecular-dynamics-validated “compromise” homology model to minimize bias that causes proteins close in sequence to a structural template to be too stable due to having the benefits...... with experimental distributions of stability effects from mutation. The residues causing the differential stability of the four isoforms are consistent with a range of compiled laccase wild type data, suggesting that we may have identified general drivers of laccase stability. Several sites near Cu, notably 79, 241...

  6. Test-retest reliability of a balance testing protocol with external perturbations in young healthy adults.

    Science.gov (United States)

    Robbins, Shawn M; Caplan, Ryan M; Aponte, Daniel I; St-Onge, Nancy

    2017-10-01

    External perturbations are utilized to challenge balance and mimic realistic balance threats in patient populations. The reliability of such protocols has not been established. The purpose was to examine test-retest reliability of balance testing with external perturbations. Healthy adults (n=34; mean age 23 years) underwent balance testing over two visits. Participants completed ten balance conditions in which the following parameters were combined: perturbation or non-perturbation, single or double leg, and eyes open or closed. Three trials were collected for each condition. Data were collected on a force plate and external perturbations were applied by translating the plate. Force plate center of pressure (CoP) data were summarized using 13 different CoP measures. Test-retest reliability was examined using intraclass correlation coefficients (ICC) and Bland-Altman plots. CoP measures of total speed and excursion in both anterior-posterior and medial-lateral directions generally had acceptable ICC values for perturbation conditions (ICC=0.46 to 0.87); however, many other CoP measures (e.g. range, area of ellipse) had unacceptable test-retest reliability (ICCCoP measures were present on the second visit indicating a potential learning effect. Non-perturbation conditions generally produced more reliable CoP measures than perturbation conditions during double leg standing, but not single leg standing. Therefore, changes to balance testing protocols that include external perturbations should be made to improve test-retest reliability and diminish learning including more extensive participant training and increasing the number of trials. CoP measures that consider all data points (e.g. total speed) are more reliable than those that only consider a few data points. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Flatworm models in pharmacological research: the importance of compound stability testing.

    Science.gov (United States)

    Stalmans, Sofie; Willems, Maxime; Adriaens, Els; Remon, Jean-Paul; D'Hondt, Matthias; De Spiegeleer, Bart

    2014-10-01

    Flatworms possess adult pluripotent stem cells, which make them extraordinary experimental model organisms to assess in vivo the undesirable effects of substances on stem cells. Currently, quality practices, implying evaluation of the stability of the test compound under the proposed experimental conditions, are uncommon in this research field. Nevertheless, performing a stability study during the rational design of in vivo assay protocols will result in more reliable assay results. To illustrate the influence of the stability of the test substance on the final experimental outcome, we performed a short-term International Conference on Harmonization (ICH)-based stability study of cyclophosphamide in the culture medium, to which a marine flatworm model Macrostomum lignano is exposed. Using a validated U(H)PLC method, it was demonstrated that the cyclophosphamide concentration in the culture medium at 20°C is lowered to 80% of the initial concentration after 21days. The multiwell plates, flatworms and diatoms, as well as light exposure, did not influence significantly the cyclophosphamide concentration in the medium. The results of the stability study have practical implications on the experimental set-up of the carcinogenicity assay like the frequency of medium renewal. This case study demonstrates the benefits of applying appropriate quality guidelines already during fundamental research increasing the credibility of the results. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Exercise testing of pre-school children using the Bruce treadmill protocol: new reference values.

    Science.gov (United States)

    van der Cammen-van Zijp, Monique H M; Ijsselstijn, Hanneke; Takken, Tim; Willemsen, Sten P; Tibboel, Dick; Stam, Henk J; van den Berg-Emons, Rita J G

    2010-01-01

    The Bruce treadmill protocol is an often-used exercise test for children and adults. Few and mainly old normative data are available for young children. In this cross-sectional observational study we determined new reference values for the original Bruce protocol in children aged 4 and 5 years. Furthermore, we compared the original protocol with the so-called 'half Bruce' protocol. In the Netherlands this half-Bruce protocol is often used for young children because of the rather large increments in workload in the original protocol. Seventy-eight healthy Dutch children participated. The maximal endurance time was the criterion of exercise capacity. The new reference values for the original Bruce protocol are presented as reference centiles. The mean (SD) endurance time using the original protocol was 10.2 (SD 1.5) min.; this was 9.4 (1.3) min. for the half-Bruce protocol. The mean difference was 50 seconds (95% CI: 29-71 s, P Bruce protocol are different and should not be considered interchangeable. Our new reference values can be used as reference values for the original Bruce protocol.

  9. Quantum Strategies: Proposal to Experimentally Test a Quantum Economics Protocol

    Science.gov (United States)

    2009-04-09

    protocols can add security to competitive situations; and analyzing the feasibility of running multi-party quantum games over metro-distance optical... games of complete informa- tion. Physics Letters A, 272:291-303, August 2000. [21] D. A. Meyer. Quantum Communication in Games . In S. M. Barnett, E ...feasibility of quantum games , we proposed to implement a proof-of-principle quantum public goods game , and to experimentally demonstrate that the quantum

  10. Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol.

    Science.gov (United States)

    O'Regan, C J; Kearney, H; Beausang, A; Farrell, M A; Brett, F M; Cryan, J B; Loftus, T E; Buckley, P G

    2018-04-01

    Epigenetic silencing of O-6-methylguanine-DNA methyltransferase (MGMT) promoter via methylation in a glioblastoma (GBM), has been correlated with a more favourable response to alkylating chemotherapeutic agents such as temozolomide. The use of global methylation surrogates such as Long Interspersed Nucleotide Element 1 (LINE1) may also be valuable in order to fully understand these highly heterogeneous tumours. In this study, we analysed both original and recurrent GBMs in 22 patients (i.e. 44 tumours), for both MGMT and LINE1 methylation status. In the 22 patients: 14 (63.6%) displayed MGMT methylation stability in the recurrent GBM versus 8 (36.4%), with instability of methylation status. No significant differences in overall and progression free survival was evident between these two groups. LINE1 methylation status remained stable for 12 (54.5%) of recurrent GBM patients versus 9 (41%) of the patients with instability in LINE1 methylation status (p = 0.02), resulting in an increase in overall survival of the stable LINE1 group (p = 0.04). The results obtained demonstrated major epigenetic instability of GBMs treated with temozolomide as part of the STUPP protocol. GBMs appear to undergo selective evolution post-treatment, and have the ability to recur with a newly reprogrammed epigenetic status. Selective targeting of the altered epigenomes in recurrent GBMs may facilitate the future development of both prognostic biomarkers and enhanced therapeutic strategies.

  11. 76 FR 50164 - Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing...

    Science.gov (United States)

    2011-08-12

    ... in commenting must do so at this time. For further information, please see the information provided...-AQ06 Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing... correct certain portions of the Protocol Gas Verification Program and Minimum Competency Requirements for...

  12. Exercise testing of pre-school children using the Bruce treadmill protocol: new reference values

    NARCIS (Netherlands)

    M.H.M. van der Cammen-van Zijp (Monique); H. IJsselstijn (Hanneke); T. Takken (Tim); S.P. Willemsen (Sten); D. Tibboel (Dick); H.J. Stam (Henk); R.J.G. van den Berg-Emons (Rita)

    2010-01-01

    textabstractThe Bruce treadmill protocol is an often-used exercise test for children and adults. Few and mainly old normative data are available for young children. In this cross-sectional observational study we determined new reference values for the original Bruce protocol in children aged 4 and 5

  13. Validity and Reproducibility of a New Treadmill Protocol: The Fitkids Treadmill Test

    NARCIS (Netherlands)

    Tim Takken; Bart C. Bongers; Elle M.W. Kotte; Janke de Groot; Alexander M.F. Winkler

    2015-01-01

    Validity and Reproducibility of a New Treadmill Protocol: The Fitkids Treadmill Test. Med. Sci. Sports Exerc., Vol. 47, No. 10, pp. 2241–2247, 2015. Purpose: This study aimed to investigate the validity and reproducibility of a new treadmill protocol in healthy children and adolescents: the Fitkids

  14. Posttreatment stability in Class II nonextraction and maxillary premolar extraction protocols.

    Science.gov (United States)

    Janson, Guilherme; Araki, Janine; Camardella, Leonardo Tavares

    2012-01-01

    To cephalometrically compare the overjet, overbite, and molar and canine relationship stability of Class II malocclusion treatment with and without maxillary premolar extractions. Two groups of 30 patients each with pre- and posttreatment matching characteristics and satisfactory finishing were used. Group 1 consisted of 30 patients treated with nonextraction at a mean pretreatment age of 12.14 years, while group 2 consisted of 30 patients treated with maxillary first premolar extractions at a mean pretreatment age of 12.87 years. Lateral cephalograms obtained before and after treatment and at a mean of 8.2 years after the end of treatment were compared. Student t tests were used to compare the initial and final dental relationships of the groups and the amount of treatment and long-term posttreatment changes. Pearson correlation coefficients were calculated to investigate correlations between treatment and long-term posttreatment dental relationship changes. In groups with matching canine relationship treatment changes, long-term stability of the overjet, overbite, and molar and canine relationships were similar in the groups. There were significant but weak correlations between treatment changes in overjet, overbite, and canine relationships with their long-term posttreatment changes. Nonextraction and maxillary premolar extraction treatment of complete Class II malocclusion have similar long-term posttreatment stability in terms of overjet, overbite, and canine and molar relationships.

  15. 7 CFR 301.92-12 - Testing protocols.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Phytophthora Ramorum § 301.92-12 Testing... confirmatory culture tests, nor do positive culture tests require confirmatory PCR or other molecular tests; however, if culture tests return other than positive results, an APHIS-approved PCR or other molecular...

  16. Draft Plan to Develop Non-Intrusive Load Monitoring Test Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Mayhorn, Ebony T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sullivan, Greg P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Petersen, Joseph M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Baechler, Michael C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-29

    This document presents a Draft Plan proposed to develop a common test protocol that can be used to evaluate the performance requirements of Non-Intrusive Load Monitoring. Development on the test protocol will be focused on providing a consistent method that can be used to quantify and compare the performance characteristics of NILM products. Elements of the protocols include specifications for appliances to be used, metrics, instrumentation, and a procedure to simulate appliance behavior during tests. In addition, three priority use cases for NILM will be identified and their performance requirements will specified.

  17. Verifiable Measurement-Only Blind Quantum Computing with Stabilizer Testing.

    Science.gov (United States)

    Hayashi, Masahito; Morimae, Tomoyuki

    2015-11-27

    We introduce a simple protocol for verifiable measurement-only blind quantum computing. Alice, a client, can perform only single-qubit measurements, whereas Bob, a server, can generate and store entangled many-qubit states. Bob generates copies of a graph state, which is a universal resource state for measurement-based quantum computing, and sends Alice each qubit of them one by one. Alice adaptively measures each qubit according to her program. If Bob is honest, he generates the correct graph state, and, therefore, Alice can obtain the correct computation result. Regarding the security, whatever Bob does, Bob cannot get any information about Alice's computation because of the no-signaling principle. Furthermore, malicious Bob does not necessarily send the copies of the correct graph state, but Alice can check the correctness of Bob's state by directly verifying the stabilizers of some copies.

  18. Investigation of Indoor Stability Testing of Polymer Solar Cell

    Directory of Open Access Journals (Sweden)

    Pelin Kavak

    2016-01-01

    Full Text Available We have fabricated organic solar cell of a new low bandgap polymer poly[4,4-bis(2-ethylhexyl-4H-cyclopenta[2,1-b:3,4-b′]dithiophene-2,6-diyl-alt-4,7-bis(2-thienyl-2,1,3-benzothiadiazole-5′,5′′-diyl] (PCPDTTBTT. We have investigated for the first time the stability tests, ISOS-L-1 and ISOS-D-3, of PCPDTTBTT solar cells. Thermal annealing of PCPDTTBTT solar cells at 80°C brought about an improvement of photocurrent generation, stability, and efficiency of the solar cells. T80 value of PCPDTTBTT solar cell is about 150 hours which is close to P3HT (235 h. PCPDTTBTT is very promising polymer for both polymer solar cell efficiency and stability.

  19. Epidemiological cut-off values for Flavobacterium psychrophilum MIC data generated by a standard test protocol

    DEFF Research Database (Denmark)

    Smith, P.; Endris, R.; Kronvall, G.

    2016-01-01

    Epidemiological cut-off values were developed for application to antibiotic susceptibility data for Flavobacterium psychrophilum generated by standard CLSI test protocols. The MIC values for ten antibiotic agents against Flavobacterium psychrophilum were determined in two laboratories. For five a...

  20. Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

    Data.gov (United States)

    National Aeronautics and Space Administration — The study protocol was successfully pilot tested with N=7 subjects (6 NASA flight surgeons and 1 Behavioral Health and Performance element Operations professional)...

  1. Health Worker Compliance with a 'Test And Treat' Malaria Case Management Protocol in Papua New Guinea.

    Science.gov (United States)

    Pulford, Justin; Smith, Iso; Mueller, Ivo; Siba, Peter M; Hetzel, Manuel W

    2016-01-01

    The Papua New Guinea (PNG) Department of Health introduced a 'test and treat' malaria case management protocol in 2011. This study assesses health worker compliance with the test and treat protocol on a wide range of measures, examines self-reported barriers to health worker compliance as well as health worker attitudes towards the test and treat protocol. Data were collected by cross-sectional survey conducted in randomly selected primary health care facilities in 2012 and repeated in 2014. The combined survey data included passive observation of current or recently febrile patients (N = 771) and interviewer administered questionnaires completed with health workers (N = 265). Across the two surveys, 77.6% of patients were tested for malaria infection by rapid diagnostic test (RDT) or microscopy, 65.6% of confirmed malaria cases were prescribed the correct antimalarials and 15.3% of febrile patients who tested negative for malaria infection were incorrectly prescribed an antimalarial. Overall compliance with a strictly defined test and treat protocol was 62.8%. A reluctance to test current/recently febrile patients for malaria infection by RDT or microscopy in the absence of acute malaria symptoms, reserving recommended antimalarials for confirmed malaria cases only and choosing to clinically diagnose a malaria infection, despite a negative RDT result were the most frequently reported barriers to protocol compliance. Attitudinal support for the test and treat protocol, as assessed by a nine-item measure, improved across time. In conclusion, health worker compliance with the full test and treat malaria protocol requires improvement in PNG and additional health worker support will likely be required to achieve this. The broader evidence base would suggest any such support should be delivered over a longer period of time, be multi-dimensional and multi-modal.

  2. 40 CFR 59.208 - Charcoal lighter material testing protocol.

    Science.gov (United States)

    2010-07-01

    ... already impregnated or treated in the charcoal; (2) How to use or apply the lighter material; and (3) How... reference point reading during each test run using a chart recorder or once every 20 seconds if using Method... test run to measure the real time organic concentration of the exhaust as methane. Record the emission...

  3. Comparative evaluation of the stability of two different dental implant designs and surgical protocols-a pilot study.

    Science.gov (United States)

    Simmons, David E; Maney, Pooja; Teitelbaum, Austin G; Billiot, Susan; Popat, Lomesh J; Palaiologou, A Archontia

    2017-12-01

    The purpose of this study was to compare a parallel wall design implant to a tapered apex design implant when placed in the posterior maxilla using two different surgical protocols. Twenty-seven patients (30 implants) were divided into three groups. All implants were 4 mm wide in diameter and 8 mm long. Group A received 10 tapered implants (OSPTX) (Astra Tech OsseoSpeed TX™) using the soft bone surgical protocol (TXSoft). Group B received 10 tapered implants (OSPTX) (AstraTech OsseoSpeedTX™) using the standard surgical protocol (TXStd). Group C received 10 parallel wall implants (OSP) (AstraTech OsseoSpeed™) using the standard surgical protocol (OStd). All implants were placed in the posterior maxilla in areas with a minimum of 8-mm crestal bone height. Resonance frequency measurements (implant stability quotient (ISQ)) and torque values were recorded to determine initial implant stability. All implants were uncovered 6 weeks after placement and restored with a functionally loaded resin provisional screw-retained crown. Resonance frequency measurements were recorded at the time of implant placement, at 6 weeks and 6 and 12 months. Twelve months after implant placement, the stability of the implants was recorded and the final restorations were placed using custom CAD/CAM fabricated abutments and cement-retained PFM DSIGN porcelain crowns. After implant restoration, bone levels were measured at 6 and 12 months with standardized radiographs. Radiographic mean bone loss was less than 0.5 mm in all groups, with no statistically significant differences between the groups. Implant survival rate at 1 year was 93.3%, with 2/30 implants failing to integrate prior to functional loading at 6 weeks. No statistically significant difference was found between ISQ measurements between the three groups at all time intervals measured. Strong positive correlations were found between overall bone loss at 6 months and insertion torque at time of placement. A very weak

  4. Measurement protocols for performance testing of dosimetry services for external radiations

    International Nuclear Information System (INIS)

    1993-01-01

    In the Health and Safety Executive's ''Requirements for the Approval of Dosimetry Services under the Ionising Radiations Regulations 1985'', it is stipulated that dosimetry services seeking approval must show that they have successfully completed a performance test. The services must arrange for the tests to be carried out on application and thereafter every 18 months, by a laboratory which has received accreditation from the National Measurement Accreditation Service (NAMAS) for the whole performance testing activity. The performance tests must be carried out to published protocols and the purpose here is to provide protocols for external, whole body film and TLD dosimetry services, and for skin and extremity dosimetry services. (Author)

  5. Functional Testing Protocols for Commercial Building Efficiency Baseline Modeling Software

    OpenAIRE

    Jump, David

    2014-01-01

    This document describes procedures for testing and validating proprietary baseline energy modeling software accuracy in predicting energy use over the period of interest, such as a month or a year. The procedures are designed according to the methodology used for public domain baselining software in another LBNL report that was (like the present report) prepared for Pacific Gas and Electric Company: ?Commercial Building Energy Baseline Modeling Software: Performance Metrics and Method Testing...

  6. Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD

    Directory of Open Access Journals (Sweden)

    Benoit Borel

    2013-01-01

    Full Text Available Exercise intolerance is a key element in the pathophysiology and course of Chronic Obstructive Pulmonary Disease (COPD. As such, evaluating exercise tolerance has become an important part of the management of COPD. A wide variety of exercise-testing protocols is currently available, each protocol having its own strengths and weaknesses relative to their discriminative, methodological, and evaluative characteristics. This paper aims to review the responsiveness of several exercise-testing protocols used to evaluate the efficacy of pharmacological and nonpharmacological interventions to improve exercise tolerance in COPD. This will be done taking into account the minimally important difference, an important concept in the interpretation of the findings about responsiveness of exercise testing protocols. Among the currently available exercise-testing protocols (incremental, constant work rate, or self-paced, constant work rate exercise tests (cycle endurance test and endurance shuttle walking test emerge as the most responsive ones for detecting and quantifying changes in exercise capacity after an intervention in COPD.

  7. Impact of standard test protocols on sporicidal efficacy.

    Science.gov (United States)

    Wesgate, R; Rauwel, G; Criquelion, J; Maillard, J-Y

    2016-07-01

    There has been an increase in the availability of commercial sporicidal formulations. Any comparison of sporicidal data from the literature is hampered by the number of different standard tests available and the use of diverse test conditions including bacterial strains and endospore preparation. To evaluate the effect of sporicidal standard tests on the apparent activity of eight biocides against Clostridium difficile and Bacillus subtilis. The activity of eight biocidal formulations including two oxidizing agents, two aldehydes, three didecyldimethylammonium chloride (DDAC) and amine formulations, and sodium hypochlorite were evaluated using four standard sporicidal tests (BS EN 14347, BS EN13704, ASTM E2197-11, and AOAC MB-15-03) against B. subtilis (ACTC 19659) and C. difficile (NCTC 11209) spores. C. difficile spores were more susceptible to the sporicides than were B. subtilis spores, regardless of the method used. There were differences in sporicidal activity between methods at 5 min but not at 60 min exposure. DDAC and amine-based products were not sporicidal when neutralized appropriately. Neutralization validation was confirmed for these biocides using the reporting format described in the BS EN standard tests, although the raw data appear to indicate that neutralization failed. The different methods, whether based on suspension or carrier tests, produced similar sporicidal inactivation data. This study suggests that detailed neutralization validation data should be reported to ensure that neutralization of active spores is effective. Failure to do so may lead to erroneous sporicidal claims. Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  8. Comparing core stability and traditional trunk exercise on chronic low back pain patients using three functional lumbopelvic stability tests.

    Science.gov (United States)

    Shamsi, Mohammad Bagher; Sarrafzadeh, Javad; Jamshidi, Aliashraf

    2015-02-01

    It is a matter of controversy whether core stability exercise is preferred to other types of exercise for chronic low back pain. Lumbopelvic stability is an important element in low back pain. No study was found using lumbopelvic stability tests in comparing core stability and other exercises. The single leg squat, dip test, and runner pose test appear to be suitable as tests for lumbopelvic stability. The aim of this study was to compare "core stability" and "traditional trunk exercise" using these tests and also the Oswestry disability questionnaire and pain intensity. Twenty-nine non-specific chronic low back pain subjects were alternately allocated in one of the two exercise groups. For both groups, a 16-sessions exercise program was provided. Before and after training: (1) video was recorded while subjects performed the tests; (2) Oswestry disability questionnaire was completed; and (3) pain intensity was measured by visual analogue scale. The test videos were scored by three physiotherapists. Statistical analysis revealed a significant improvement in stability test scores (p = 0.020 and p = 0.041) and reduction in disability (p stability or equal effectiveness of TTE and CSE on improving LPS. The non-significant differences may also be attributable to the lack of sensitivity of our tests to assess stability change in two groups after training given the relatively small sample size.

  9. Protocol for assessing alcohol withdrawal syndrome by nursing professionals in emergency services: a pilot test

    OpenAIRE

    Luis,Margarita Antonia Villar; Lunetta,Ana Carolina Fuza; Ferreira,Paulo Sérgio

    2008-01-01

    OBJECTIVES: This work speaks of a pilot test administered in four public services with emergency care (one at a hospital and three at community clinics) in the city of Ribeirão Preto, São Paulo, to test an assessment protocol for Alcohol Withdrawal Syndrome. Involved were auxiliaries, technicians and soon-to-be-nurses. The object was to evaluate the protocol´s potential as a guide to nursing care, and to test whether it was adequate in terms of comprehension and applicability. METHODS: A prot...

  10. Standard Test Method for Dimensional Stability of Sandwich Core Materials

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2002-01-01

    1.1 This test method covers the determination of the sandwich core dimensional stability in the two plan dimensions. 1.2 The values stated in SI units are to be regarded as the standard. The inch-pound units given may be approximate. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  11. Shear Ram Verification Test Protocol (VTP) Best Practices

    Energy Technology Data Exchange (ETDEWEB)

    Lindley, Roy A. [Argonne National Lab. (ANL), Argonne, IL (United States); Braun, Joseph C. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    A blowout preventer (BOP) is a critical component used on subsea oil and gas wells during drilling, completion, and workover operations on the U. S. outer continental shelf (OCS). The purpose of the BOP is to seal oil and gas wells, and in the case of an emergency well-control event, to prevent the uncontrolled release of hydrocarbons. One of the most important components of the BOP is the hydraulically operated blind shear ram (BSR) that shears drilling-related components, such as drill pipes, casings, tubings, and wire-related tools that may have been placed in the well. In addition to shearing these components, the BSR must form a seal to keep hydrocarbons within the well bore, even when under the highest well-fluid pressures expected. The purpose of this document is for Argonne National Laboratory (ANL) to provide an independent view, based on current regulations, and best practices for testing and confirming the operability and suitability of BSRs under realistic (or actual) well conditions.

  12. Testing the stability of travel expenditures in Nigeria

    International Nuclear Information System (INIS)

    Osula, D.O.A.; Adebisi, O.

    2001-01-01

    A report is presented on a study carried out to develop a functional form for travel money expenditure in a Nigerian setting, and test its stability against energy policy change, specifically the fuel price increase of October 1994. The Box-Cox transformation regression approach was adopted in the modelling exercise in order to evolve a data-defined functional form and ensure a more rational basis for the stability test. The results of the modelling exercise show that while statistically significant functional forms were estimated for the 'before' and 'after' fuel price increase periods, the functional forms estimated are not stable across the periods. Thus 'travel budget' is as yet not usable as a term for travel expenditures in Nigeria. The implication of this for travel demand modelling in Nigeria is that, at least till other evidences prove otherwise, there is as yet no basis for using the 'Universal Mechanism of Travel' model developed by Zahavi (The UMOT Project. Report No. DOT-RSPA-DPB-20-79-3; The UMOT Travel Model II Report No. DOT-RSPA-DPB-50-82-11). Of disposable income and total expenditure, the former has proved to be more appropriate for use as 'available money' for the estimation of travel expenditures in Nigeria in the 'before' energy policy change period, while total expenditure proved appropriate in the 'after' period. (author)

  13. Mechanical Stability Study for Integrable Optics Test Accelerator at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    McGee, Mike [Fermilab; Andrews, Richard [Fermilab; Carlson, Kermit [Fermilab; Leibfritz, Jerry [Fermilab; Nobrega, Lucy [Fermilab; Valishev, Alexander [Fermilab

    2016-07-01

    The Integrable Optics Test Accelerator (IOTA) is proposed for operation at Fermilab. The goal of IOTA is to create practical nonlinear accelerator focusing systems with a large frequency spread and stable particle motion. The IOTA is a 40 m circumference, 150 MeV (e-), 2.5 MeV (p⁺) diagnostic test ring. A heavy low frequency steel floor girder is proposed as the primary tier for IOTA device component support. Two design lengths; (8) 4 m and (2) 2.8 m long girders with identical cross section completely encompass the ring. This study focuses on the 4 m length girder and the development of a working prototype. Hydrostatic Level Sensor (HLS), temperature, metrology and fast motion measurements characterize the anticipated mechanical stability of the IOTA ring.

  14. Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Groza, Voicu; Isleifsson, Fridrik Rafn

    2012-01-01

    Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads......Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads...

  15. Improving the Sandia Test Protocols with Advanced Inverter Functionality Testing of INV3, VV11, FW21, and L/HVRT

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    Sandia National Laboratories has created a test protocol for IEC TR 61850-90-7 advanced distributed energy resource (DER) functions, titled "Test Protocols for Advanced Inverter Interoperability Functions," often referred to as the Sandia Test Protocols. This document is currently in draft form, but has been shared with stakeholders around the world with the ultimate goal of collaborating to create a consensus set of test protocols which can be then incorporated into an International Electrotechnical Commission (IEC) and/or Underwriters Laboratories (UL) certification standard. The protocols are designed to ensure functional interoperability of DER (primarily photovoltaic (PV) inverters and energy storage systems) as specified by the IEC technical report through communication and electrical tests. In this report, Sandia exercises the electrical characterization portion of the test protocols for four functions: constant power factor (INV3), volt-var (VV11), frequency-watt (FW21), and Low and High Voltage Ride Through (L/HVRT). The goal of the tests reported here was not to characterize the performance of the equipment under test (EUT), but rather to (a) exercise the draft Sandia Test Protocols in order to identify any revisions needed in test procedures, conditions, or equipment and (b) gain experience with state-of-the-art DER equipment to determine if the tests put unrealistic or overly aggressive requirements on EUT operation. In performing the work according to the current versions of the protocols, Sandia was able to identify weaknesses in the current versions and suggest improvements to the test protocols.

  16. Validity and reproducibility of a new treadmill protocol: the Fitkids Treadmill Test.

    NARCIS (Netherlands)

    Kotte, E.M.W.; Groot, J.F. de; Bongers, B.C.; Winkler, A.M.F.; Takken, T.

    2015-01-01

    Purpose: This study aimed to investigate the validity and reproducibility of a new treadmill protocol in healthy children and adolescents: the Fitkids Treadmill Test (FTT). Methods:Sixty-eight healthy children and adolescents (6-18 yr) were randomly divided into a validity group (14 boys and 20

  17. Validity and Reproducibility of a New Treadmill Protocol : The Fitkids Treadmill Test

    NARCIS (Netherlands)

    Kotte, Elles M W; De Groot, Janke F.; Bongers, Bart C.; Winkler, Alexander M F; Takken, Tim

    2015-01-01

    Purpose This study aimed to investigate the validity and reproducibility of a new treadmill protocol in healthy children and adolescents: the Fitkids Treadmill Test (FTT). Methods Sixty-eight healthy children and adolescents (6-18 yr) were randomly divided into a validity group (14 boys and 20

  18. Modified calibration protocol evaluated in a model-based testing of SBR flexibility

    DEFF Research Database (Denmark)

    Corominas, Lluís; Sin, Gürkan; Puig, Sebastià

    2011-01-01

    statistical evaluation of the calibration outcome. The updated calibration protocol is then evaluated on a case study to obtain a thoroughly validated model for testing the flexibility of an N-removing SBR to adapt the operating conditions to the changing influent wastewater load. The performance of reference...

  19. Exploring two methods of usability testing: concurrent versus retrospective think-aloud protocols

    NARCIS (Netherlands)

    van den Haak, M.J.; de Jong, Menno D.T.

    2003-01-01

    Think-aloud protocols are commonly used for the usability testing of instructional documents, Web sites and interfaces. This paper addresses the benefits and drawbacks of two think-aloud variations: the traditional concurrent think-aloud method and the less familiar retrospective think-aloud

  20. Exploring Two Methods of Usability Testing : Concurrent versus Retrospective Think-Aloud Protocols

    NARCIS (Netherlands)

    Van den Haak, Maaike J.; De Jong, Menno D. T.

    2003-01-01

    Think-aloud protocols are commonly used for the usability testing of instructional documents, web sites and interfaces. This paper addresses the benefits and drawbacks of two think-aloud variations: the traditional concurrent think-aloud method and the less familiar retrospective think-aloud

  1. Elastic Stability of Concentric Tube Robots: A Stability Measure and Design Test.

    Science.gov (United States)

    Gilbert, Hunter B; Hendrick, Richard J; Webster, Robert J

    2016-02-01

    Concentric tube robots are needle-sized manipulators which have been investigated for use in minimally invasive surgeries. It was noted early in the development of these devices that elastic energy storage can lead to rapid snapping motion for designs with moderate to high tube curvatures. Substantial progress has recently been made in the concentric tube robot community in designing snap-free robots, planning stable paths, and characterizing conditions that result in snapping for specific classes of concentric tube robots. However, a general measure for how stable a given robot configuration is has yet to be proposed. In this paper, we use bifurcation and elastic stability theory to provide such a measure, as well as to produce a test for determining whether a given design is snap-free (i.e. whether snapping can occur anywhere in the unloaded robot's workspace). These results are useful in designing, planning motions for, and controlling concentric tube robots with high curvatures.

  2. Evaluation of mid-term stability of night vision tests.

    Science.gov (United States)

    Levy, Y; Glovinsky, Y

    1997-07-01

    Dark adaptation rate, scotopic retinal sensitivity and contrast sensitivity under mesopic conditions, but not visual acuity, have been shown to be directly related to the ability to identify military targets at night. These parameters can be used to select personnel for specific military tasks demanding excellent night vision, as well as to assess pharmacological effects on night vision. To evaluate the mid-term (2 to 6-week period) stability of night vision tests based on assessment of the above parameters. Dark adaptation rate, scotopic retinal sensitivity and contrast sensitivity under mesopic conditions were studied in 16 young volunteers during a 6-week period. Tests of scotopic retinal sensitivity (after 30 min of dark adaptation) exhibited high reproducibility and a low fluctuation rate, with a high correlation between values at week 0 and at 2-week intervals during the following 6 weeks of the study (rs (week 0 to week 6) = 0.81, p = 0.0001). The reproducibility of mesopic contrast sensitivity tests (average of 1.5, 3, 6 and 12 cycles per degree, (cpd)) was fair (rs (week 0 to week 2) = 0.67, p = 0.0045), whereas that of dark adaptation rate tests was poor. In view of the reproducibility characteristics of these night vision tests, assessment of night vision ability in pilots and military personnel, as well as assessment of pharmacological effects on night vision, may be based on scotopic retinal sensitivity (after 30 min of dark adaptation) and contrast sensitivity under mesopic conditions (average of 1.5, 3, 6 and 12 cpd).

  3. Test Protocol for Room-to-Room Distribution of Outside Air by Residential Ventilation Systems

    Energy Technology Data Exchange (ETDEWEB)

    Barley, C. D.; Anderson, R.; Hendron, B.; Hancock, E.

    2007-12-01

    This test and analysis protocol has been developed as a practical approach for measuring outside air distribution in homes. It has been used successfully in field tests and has led to significant insights on ventilation design issues. Performance advantages of more sophisticated ventilation systems over simpler, less-costly designs have been verified, and specific problems, such as airflow short-circuiting, have been identified.

  4. Internet Protocol Security (IPSEC): Testing and Implications on IPv4 and IPv6 Networks

    Science.gov (United States)

    2008-08-27

    establishment of VPN tunnels with other networks. Due to time constraints, we did not modify OpenSwan or attempt any further application of IPSec ... VPNs Illustrated: Tunnels , VPNs , and IPsec , Addison-Wesley, 2006. [5] D. Maughan, Internet Security Association and Key Management Protocol...setups. We were not able to test on the Linux machine due to the nature of the implementation of IPSec , namely that of VPNs solely. From the testing

  5. Mammalian Toxicology Testing: Problem Definition Study, AMTR Protocol/Pricing Report.

    Science.gov (United States)

    1981-04-01

    excretory . behavioral or other activity. as well as signs indicating an adverse effect on the central nervous system 54 ic Systcm, li". PROTOCOL Test No...A0-A112 832 LIFE SYSTEMS INC CLEVELAND OH F/G 6/20 MAMMA LIAN TOXICOLOGY TESTING: PROBLEM DEFINITION STUDY, AMTR PR--ETC(U) UNCLASSIFIED LSI-TR-477...S. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK AREA & WORK UNIT NUMBERS LIEL SYSTEMS , INC. ..... 24755 Highpoint Road

  6. Stability testing of vaccines: Developing Countries Vaccine Manufacturers' Network (DCVMN) perspective.

    Science.gov (United States)

    Jadhav, Suresh S; Dogar, Vikas; Gautam, Manish; Gairola, Sunil

    2009-11-01

    Stability testing is an integral part of the vaccine manufacturing process and is crucial for the success of immunization programs. WHO (World Health Organization) has recently published guidelines on the stability testing of vaccines. These guidelines enlist scientific basis and principles for stability testing at various stages like development, pre-clinical, clinical, licensing, lot release and post-licensure monitoring. DCVMN (Developing Countries Vaccine Manufacturers' Network) is an international body of developing countries vaccine manufacturers and has viewpoints on technical and administrative issues in stability testing of vaccines. We here highlight viewpoints, possible roles and global expectations of DCVMN in the area of stability testing of vaccines.

  7. Progress Toward a Stabilization and Preconditioning Protocol for Polycrystalline Thin-Film Photovoltaic Modules

    Energy Technology Data Exchange (ETDEWEB)

    del Cueto, J. A.; Deline, C. A.; Rummel, S. R.; Anderberg, A.

    2010-08-01

    Cadmium telluride (CdTe) and copper indium gallium diselenide (CIGS) thin-film photovoltaic (PV) modules can exhibit substantial variation in measured performance depending on prior exposure history. This study examines the metastable performance changes in these PV modules with the goal of establishing standard preconditioning or stabilization exposure procedures to mitigate measured variations prior to current-voltage (IV) measurements.

  8. Masonry fireplace emissions test method: Repeatability and sensitivity to fueling protocol.

    Science.gov (United States)

    Stern, C H; Jaasma, D R; Champion, M R

    1993-03-01

    A test method for masonry fireplaces has been evaluated during testing on six masonry fireplace configurations. The method determines carbon monoxide and particulate matter emission rates (g/h) and factors (g/kg) and does not require weighing of the appliance to determine the timing of fuel loading.The intralaboratory repeatability of the test method has been determined from multiple tests on the six fireplaces. For the tested fireplaces, the ratio of the highest to lowest measured PM rate averaged 1.17 and in no case was greater than 1.32. The data suggest that some of the variation is due to differences in fuel properties.The influence of fueling protocol on emissions has also been studied. A modified fueling protocol, tested in large and small fireplaces, reduced CO and PM emission factors by roughly 40% and reduced CO and PM rates from 0 to 30%. For both of these fireplaces, emission rates were less sensitive to fueling protocol than emission factors.

  9. Measurement error of a simplified protocol for quantitative sensory tests in chronic pain patients

    DEFF Research Database (Denmark)

    Müller, Monika; Biurrun Manresa, José; Limacher, Andreas

    2017-01-01

    BACKGROUND AND OBJECTIVES: Large-scale application of Quantitative Sensory Tests (QST) is impaired by lacking standardized testing protocols. One unclear methodological aspect is the number of records needed to minimize measurement error. Traditionally, measurements are repeated 3 to 5 times......, and their mean value is considered. When transferring QST to a clinical setting, reducing the number of records would be desirable to meet the time constraints encountered in a routine clinical environment and to reduce the testing burden to chronic pain patients. However, there might be a trade-off between...... to reduce the testing burden. This would allow saving time, resources, and patient discomfort....

  10. Test Area North Pool Stabilization Project: Environmental assessment

    International Nuclear Information System (INIS)

    1996-05-01

    The Test Area North (TAN) Pool is located within the fenced TAN facility boundaries on the Idaho National Engineering Laboratory (INEL). The TAN pool stores 344 canisters of core debris from the March, 1979, Three Mile Island (TMI) Unit 2 reactor accident; fuel assemblies from Loss-of-Fluid Tests (LOFT); and Government-owned commercial fuel rods and assemblies. The LOFT and government owned commercial fuel rods and assemblies are hereafter referred to collectively as open-quotes commercial fuelsclose quotes except where distinction between the two is important to the analysis. DOE proposes to remove the canisters of TMI core debris and commercial fuels from the TAN Pool and transfer them to the Idaho Chemical Processing Plant (ICPP) for interim dry storage until an alternate storage location other than at the INEL, or a permanent federal spent nuclear fuel (SNF) repository is available. The TAN Pool would be drained and placed in an industrially and radiologically safe condition for refurbishment or eventual decommissioning. This environmental assessment (EA) identifies and evaluates environmental impacts associated with (1) constructing an Interim Storage System (ISS) at ICPP; (2) removing the TMI and commercial fuels from the pool and transporting them to ICPP for placement in an ISS, and (3) draining and stabilizing the TAN Pool. Miscellaneous hardware would be removed and decontaminated or disposed of in the INEL Radioactive Waste Management Complex (RWMC). This EA also describes the environmental consequences of the no action alternative

  11. Draft environmental assessment -- Test Area North pool stabilization project update

    International Nuclear Information System (INIS)

    1997-06-01

    The purpose of this Environmental Assessment (EA) is to update the ''Test Area North Pool Stabilization Project'' EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped form the Ea/FONSI issued May 6, 1996. The origin and nature of the TMI core debris and the proposed drying process are described and analyzed in detail in this EA. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN

  12. Environmental Assessment -- Test Area North pool stabilization project update

    International Nuclear Information System (INIS)

    1997-08-01

    The purpose of this Environmental Assessment (EA) is to update the ''Test Area North Pool Stabilization Project'' EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped from the EA/FONSI issued May 6, 1996. A new drying process was subsequently developed and is analyzed in Section 2.1.2 of this document. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN

  13. Environmental Assessment -- Test Area North pool stabilization project update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    The purpose of this Environmental Assessment (EA) is to update the ``Test Area North Pool Stabilization Project`` EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped from the EA/FONSI issued May 6, 1996. A new drying process was subsequently developed and is analyzed in Section 2.1.2 of this document. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN.

  14. Draft environmental assessment -- Test Area North pool stabilization project update

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The purpose of this Environmental Assessment (EA) is to update the ``Test Area North Pool Stabilization Project`` EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped form the Ea/FONSI issued May 6, 1996. The origin and nature of the TMI core debris and the proposed drying process are described and analyzed in detail in this EA. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN.

  15. Stabilization

    Directory of Open Access Journals (Sweden)

    Muhammad H. Al-Malack

    2016-07-01

    Full Text Available Fuel oil flyash (FFA produced in power and water desalination plants firing crude oils in the Kingdom of Saudi Arabia is being disposed in landfills, which increases the burden on the environment, therefore, FFA utilization must be encouraged. In the current research, the effect of adding FFA on the engineering properties of two indigenous soils, namely sand and marl, was investigated. FFA was added at concentrations of 5%, 10% and 15% to both soils with and without the addition of Portland cement. Mixtures of the stabilized soils were thoroughly evaluated using compaction, California Bearing Ratio (CBR, unconfined compressive strength (USC and durability tests. Results of these tests indicated that stabilized sand mixtures could not attain the ACI strength requirements. However, marl was found to satisfy the ACI strength requirement when only 5% of FFA was added together with 5% of cement. When the FFA was increased to 10% and 15%, the mixture’s strength was found to decrease to values below the ACI requirements. Results of the Toxicity Characteristics Leaching Procedure (TCLP, which was performed on samples that passed the ACI requirements, indicated that FFA must be cautiously used in soil stabilization.

  16. The reliability and response stability of dynamic testing of the vestibulo-ocular reflex in patients with vestibular disease.

    Science.gov (United States)

    Mohammad, Maha T; Whitney, Susan L; Marchetti, Gregory F; Sparto, Patrick J; Ward, Bryan K; Furman, Joseph M

    2011-01-01

    The purpose of the study was to investigate the test-retest reliability and response stability of the Dynamic Visual Acuity (DVA) and Gaze Stabilization Test (GST) in patients with vestibular disorders. Twenty-nine patients with vestibular disease (16-78 years) participated. Subjects performed the GST and DVA in pitch and yaw planes, twice in one session and once after 7-10 days. The GST output is the maximum head velocity at which the patient was able to identify orientation of the letter E. The DVA output is the change in visual acuity when moving the head compared to static acuity. Subjects indicated their level of dizziness and visual blurring using a visual analog scale. Within- and between-sessions intraclass correlation coefficients ranged between 0-0.5 for the DVA and GST measures, with better correlations for within-session assessments. Response stability (standard error of measurement / mean) of the GST ranged between 21-32% and the DVA ranged between 25-69% with vertical DVA being most influenced by measurement error. Subjects' symptoms did not correlate with performance on either test. The current test protocol needs refinement to enhance reliability and stability in persons with vestibular disorders.

  17. Comparison of Resistance-Based Walking Cardiorespiratory Test to The Bruce Protocol.

    Science.gov (United States)

    Hurt, Christopher P; Bamman, Marcas; Naidu, Avantika; Brown, David A

    2017-12-11

    Cardiorespiratory fitness is assessed through graded exercise tests that determine the maximum amount of sustained mechanical work that an individual can perform while also providing health and fitness related information. This manuscript describes a novel method to perform graded exercise tests that uses posteriorly directed resistive forces. The purpose of this investigation is to validate a novel resistance based test in comparison to a traditional speed and incline based test in a cohort of non-impaired individuals. Twenty non-impaired individuals, 8 males, 12 females, mean age 28.4± 9.6, range 20-54 years old. Participants performed two maximal exercise tests. The speed and incline based test used the Bruce protocol and increased treadmill incline and speed every three minutes. The resistance based test used a robotic device interfaced with the treadmill that provided specified horizontal resistive forces at the center of mass calculated to match each Bruce Protocol stage while individuals walked at 1.1 m/s. Participants obtained ∼3% higher maximum V˙O2 measure using the speed and incline based method (dependent t-test p=0.08). V˙O2 peaks between tests were strongly correlated (r=0.93, ptests. We found a significant linear relationship between mass-specific work rate and measured V˙O2 stage-by-stage for both tests, but no significant difference between each linear fit (p=0.84). These data suggest horizontal resistive forces while walking on a treadmill, can be used to increase aerobic effort in a way that closely simulates work rates of the Bruce Protocol.

  18. Comparison of Aerobic Performance Testing Protocols in Elite Male Wheelchair Basketball Players

    Directory of Open Access Journals (Sweden)

    Molik Bartosz

    2017-12-01

    Full Text Available In wheelchair sports, aerobic performance is commonly assessed with the use of an arm crank ergometer (ACE, a wheelchair ergometer (WCE or a wheelchair treadmill (WCT. There are different protocols to identify peak oxygen uptake in wheelchair sports; however, only a few protocols have been applied to evaluate these conditions in wheelchair basketball players. The purpose of this study was to compare physiological responses during maximal exercise testing with the use of ACE and WCT in wheelchair basketball players. Twelve elite male wheelchair basketball players participated in this study. The research was performed during a training camp of the Polish National Wheelchair Basketball Team. The study participants were divided into two functional categories: A (players with class 1.0 - 2.5 and B (players with class 3.0 - 4.5. Two main maximal exercise tests, i.e. wheelchair treadmill stress test (WCT test and arm crank ergometer stress test (ACE test were used to evaluate aerobic performance of the players. There were no statistically significant differences in aerobic tests between the players from both groups. The comparison of results achieved in two aerobic tests performed on WCT and ACE did not reveal any significant differences between the analyzed variables (peak heart rate (HRpeak, peak oxygen uptake (VO2peak, minute ventilation (VE, anaerobic threshold (AT, lactate concentration (LApeak, and a drop in lactate concentration (%LA. Strong correlations between results achieved in WCT and ACE tests were found for VO2peak, VE and LApeak. The main conclusion of the study is that both WCT and ACE tests may be useful when determining aerobic capacity of wheelchair basketball players. Moreover, both protocols can be used by athletes regardless of their functional capabilities and types of impairment.

  19. Influence of the Hole Transporting Layer on the Thermal Stability of Inverted Organic Photovoltaics Using Accelerated-Heat Lifetime Protocols.

    Science.gov (United States)

    Hermerschmidt, Felix; Savva, Achilleas; Georgiou, Efthymios; Tuladhar, Sachetan M; Durrant, James R; McCulloch, Iain; Bradley, Donal D C; Brabec, Christoph J; Nelson, Jenny; Choulis, Stelios A

    2017-04-26

    High power conversion efficiency (PCE) inverted organic photovoltaics (OPVs) usually use thermally evaporated MoO 3 as a hole transporting layer (HTL). Despite the high PCE values reported, stability investigations are still limited and the exact degradation mechanisms of inverted OPVs using thermally evaporated MoO 3 HTL remain unclear under different environmental stress factors. In this study, we monitor the accelerated lifetime performance under the ISOS-D-2 protocol (heat conditions 65 °C) of nonencapsulated inverted OPVs based on the thiophene-based active layer materials poly(3-hexylthiophene) (P3HT), poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl

  20. Standard Test Method for Preparing Aircraft Cleaning Compounds, Liquid Type, Water Base, for Storage Stability Testing

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2002-01-01

    1.1 This test method covers the determination of the stability in storage, of liquid, water-base chemical cleaning compounds, used to clean the exterior surfaces of aircraft. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  1. A formal protocol test procedure for the Survivable Adaptable Fiber Optic Embedded Network (SAFENET)

    Science.gov (United States)

    High, Wayne

    1993-03-01

    This thesis focuses upon a new method for verifying the correct operation of a complex, high speed fiber optic communication network. These networks are of growing importance to the military because of their increased connectivity, survivability, and reconfigurability. With the introduction and increased dependence on sophisticated software and protocols, it is essential that their operation be correct. Because of the speed and complexity of fiber optic networks being designed today, they are becoming increasingly difficult to test. Previously, testing was accomplished by application of conformance test methods which had little connection with an implementation's specification. The major goal of conformance testing is to ensure that the implementation of a profile is consistent with its specification. Formal specification is needed to ensure that the implementation performs its intended operations while exhibiting desirable behaviors. The new conformance test method presented is based upon the System of Communicating Machine model which uses a formal protocol specification to generate a test sequence. The major contribution of this thesis is the application of the System of Communicating Machine model to formal profile specifications of the Survivable Adaptable Fiber Optic Embedded Network (SAFENET) standard which results in the derivation of test sequences for a SAFENET profile. The results applying this new method to SAFENET's OSI and Lightweight profiles are presented.

  2. Test-retest reliability of jump execution variables using mechanography: a comparison of jump protocols.

    Science.gov (United States)

    Fitzgerald, John S; Johnson, LuAnn; Tomkinson, Grant; Stein, Jesse; Roemmich, James N

    2018-05-01

    Mechanography during the vertical jump may enhance screening and determining mechanistic causes underlying physical performance changes. Utility of jump mechanography for evaluation is limited by scant test-retest reliability data on force-time variables. This study examined the test-retest reliability of eight jump execution variables assessed from mechanography. Thirty-two women (mean±SD: age 20.8 ± 1.3 yr) and 16 men (age 22.1 ± 1.9 yr) attended a familiarization session and two testing sessions, all one week apart. Participants performed two variations of the squat jump with squat depth self-selected and controlled using a goniometer to 80º knee flexion. Test-retest reliability was quantified as the systematic error (using effect size between jumps), random error (using coefficients of variation), and test-retest correlations (using intra-class correlation coefficients). Overall, jump execution variables demonstrated acceptable reliability, evidenced by small systematic errors (mean±95%CI: 0.2 ± 0.07), moderate random errors (mean±95%CI: 17.8 ± 3.7%), and very strong test-retest correlations (range: 0.73-0.97). Differences in random errors between controlled and self-selected protocols were negligible (mean±95%CI: 1.3 ± 2.3%). Jump execution variables demonstrated acceptable reliability, with no meaningful differences between the controlled and self-selected jump protocols. To simplify testing, a self-selected jump protocol can be used to assess force-time variables with negligible impact on measurement error.

  3. Acceptance testing in digital systems of mammography. Protocols applicability; Pruebas de aceptacion en equipos digitales de mamografia. Aplicabilidad de protocolos

    Energy Technology Data Exchange (ETDEWEB)

    Bermudez, R.; Espana, M.L.; Garcia Castanon, P.; Gomez Barrado, A.; Rodriguez Martin, G.; Fernandez Bedoya, B.

    2011-07-01

    Acceptance testing of mammographic imaging systems technical is the first approach in order to guarantee that mammograms will be achieved with the minimum radiation dose compatible with an image quality suitable for diagnose purposes. The aim of this study is to assess the practical applicability of different protocols in acceptance test of digital mammographic systems. This study has been carried out on the results of the acceptance tests of five flat panel digital mammographic systems. Parameters established in the systems technical specifications and those evaluated in the consulted protocols were tested. Due to the fact that the legislation in our country does not demand to consider a specific protocol, the results obtained were also compared considering different existing protocols. Results show discrepancies between manufacturers limiting values and those established in the protocols. Some parameters, such as the automatic exposure control compensation and the detector noise, were found out to meet or not the limiting value, depending on the selected protocol. From our results we could suggest, that protocols from manufacturers should be adapted to acknowledged documents on acceptance testing in digital mammography. They buyer representative could even specify the protocol to be followed during the acceptance tests. (Author). 25 refs.

  4. Acceptance testing in digital systens of mammography. Protocols applicability; Pruebas de aceptacion en equipos digitales de mamografia. Aplicabilidad de protocolos

    Energy Technology Data Exchange (ETDEWEB)

    Bermudez, R.; Espana, M.L.; Garcia Castanon, P.; Gomez Barrado, A.; Rodriguez Martin, G.; Fernandez Bedoya, B.

    2011-07-01

    Acceptance testing of mammographic imaging systems technical is the first approach in order to guarantee that mammograms will be achieved with the minimun radiation dose compatible with an image quality sutiable for diagnose purposes. The aim of this study is to assess the practical applicability of different protocols in acceptance test of digital mammographyc systems. This study has been carried out on the results of ltyhe acceptance tests of five flat panel digital mammographic systems. Parameters established in the systems technical specifications and those evaluated in the consulted protocols were tested. Due to the fact that the legislation oin our country does not demand to consider a specific protocol, the results obtained were also compared considering different existing protocols. Results show discrepancies between manufacturers limiting values and those established in the protocols. Some parameters, such as the authomatic exposure control compensation and the detector noise, were found out to meet or not the limiting value, depending on the selected protocol. From our results we could suggest, that protocols from manufacturers should be adapted to acknowledged documents on acceptance testing in digital mammography. They buyer representative could even specify the protocol to be followed during the acceptance tests. (Author). 25 refs.

  5. A proposed electroacoustic test protocol for personal FM receivers coupled to cochlear implant sound processors.

    Science.gov (United States)

    Schafer, Erin C; Musgrave, Elizabeth; Momin, Sadaf; Sandrock, Carl; Romine, Denise

    2013-01-01

    Current fitting guidelines from the American Academy of Audiology (Academy) support the use of objective electroacoustic measures and behavioral testing when fitting frequency modulation (FM) systems to hearing aids. However, only behavioral testing is recommended when fitting FM systems to individuals with cochlear implants (CIs) because a protocol for conducting electroacoustic measures has yet to be developed for this population. The purpose of this study was to propose and examine the validity of a newly developed, objective, electroacoustic test protocol for fitting electrically and electromagnetically coupled FM systems to CI sound processors. Electroacoustic measures were conducted and replicated in the laboratory with three contemporary CI sound processors and several FM system combinations. A repeated measures design was used with four participants to examine the validity of the proposed electroacoustic test protocol. Three contemporary CI sound processors were tested electroacoustically in the laboratory while coupled to combinations of five FM receivers and four FM transmitters. Two adolescents using Cochlear Nucleus 5 sound processors and two adult participants using MED-EL OPUS 2 sound processors completed behavioral and subjective measures. Using current hearing aid practice guidelines from the Academy, electroacoustic measurements were conducted in the laboratory with the CIs and FM systems to determine transparency, where equivalent inputs to the CI and FM microphones result in equivalent outputs. Using a hearing aid analyzer, acoustic output from the CI sound processor was measured via monitor earphones and specialized equipment from CI manufacturers with 65 dB SPL speech inputs (1) to the sound processor and (2) to the FM transmitter microphones. The FM gain or volume was adjusted to attempt to achieve transparency for outputs from the two input devices. The four participants completed some or all of the following measures: speech recognition in

  6. Validity of critical frequency test for measuring table tennis aerobic endurance through specific protocol.

    Science.gov (United States)

    Zagatto, Alessandro M; Papoti, Marcelo; Gobatto, Claudio A

    2008-01-01

    The aim of this study was to validate critical frequency specific test (critf) for the estimation of the aerobic endurance in table tennis players. Eight male international-level table tennis players participated of this study. Specific tests were applied by using a mechanical ball thrower to control the intensity of the exercise. The critf was determined by applying three or four series of exercises to exhaustion (Tlim). The critf was evaluated by using lactate steady state test (90, 100, and 106 % of critf intensity). The other specific test was an incremental protocol used to determine the anaerobic threshold (AnTBI) and the onset of blood lactate accumulation (OBLA) using a ball thrower. The critf (39.87 ± 3.31 balls·min(-1)) was not significantly different among AnTBI (48.11 ± 7.36 balls·min(- 1)) and OBLA3.5 (49.36 ± 12.04 balls·min(-1)) frequencies and it was correlated with AnTBI parameter (r = 0.78). At frequencies of the 90 and 100% of critf a dynamic equilibrium was verified in lactate concentration between the eighth and twentieth minutes. However, this dynamic equilibrium was not found at 106% intensity. The data indicate that in table tennis the critf model can be used for measuring the aerobic endurance. Key pointsIn table tennis is need the use of a specific protocol for evaluation of the aerobic endurance.The critical frequency test in table tennis seems to represent the intensity of maximal equilibrium of lactatemia.The critical frequency test can be used for measuring table tennis aerobic endurance through specific protocol.

  7. STABILIZATION AND TESTING OF MERCURY CONTAINING WASTES: BORDEN SLUDGE

    Science.gov (United States)

    This report details the stability assessment of a mercury containing sulfide treatment sludge. Information contained in this report will consist of background data submitted by the geneerator, landfill data supplied by EPA and characterization and leaching studies conducted by UC...

  8. Overview of the Meraka wireless grid test bed for evaluation of ad-hoc routing protocols

    CSIR Research Space (South Africa)

    Johnson, D

    2007-09-01

    Full Text Available - and worst-case data rate in a network with shared channel access, as the number of hops increases. However, recent work done by the same authors [3] using a real test bed, employing laptops equipped with Standard (“802.11”) based radios..., OLSR and DYMO Index Terms—ad-hoc networks, IEEE 802.11 standard, wireless grid test bed I.INTRODUCTION One of the key challenges for researchers in the field of wireless networking protocol design, is the ability to carry out...

  9. Behavior of Stabilized Peat Soils in Unconfined Compression Tests

    OpenAIRE

    Wong L. Sing; Roslan Hashim; Faisal H. Ali

    2008-01-01

    Problem statement: Deep stabilized peat columns were known to be economical at forming foundations to support highway embankments constructed on deep peat land. However, failure in the formation of the columns with adequate strength was often attributed to unsuitable type and insufficient dosage of binder added to the soil. Organic matter in peat was known to impede the cementing process in the soil, thus retarding the early strength gain of stabilized peat. Approach: To evaluate the strength...

  10. Whole-body prepulse inhibition protocol to test sensorymotor gating mechanisms in monkeys.

    Science.gov (United States)

    Saletti, Patricia G; Maior, Rafael S; Hori, Etsuro; Almeida, Ricardo Miyasaka de; Nishijo, Hisao; Tomaz, Carlos

    2014-01-01

    Prepulse inhibition (PPI) is the decrease of startle reflex amplitude when a slight stimulus is previously generated. This paradigm may provide valuable information about sensorimotor gating functionality. Here we aimed at determining the inhibited and uninhibited startle response of capuchin monkeys (Sapajus spp.), and to evaluate the role of the superior colliculus in PPI. Capuchin monkeys were tested in a whole-body protocol, to determine the best startle amplitude and interstimuli interval. Additionally we tested two subjects with bilateral superior colliculus damage in this protocol. Results show that 115 dB auditory pulse has induced the best startle response. In contrast to reports in other species, no habituation to the auditory stimuli was observed here in capuchins. Also, startle reflex inhibition was optimal after 120 msec interstimuli interval. Finally, there was a downward tendency of percentage inhibition in superior colliculus-lesioned monkeys. Our data provides the possibility of further studies with whole-body protocol in capuchin monkeys and reinforces the importance of the superior colliculus in PPI.

  11. The field-testing of a novel integrated mapping protocol for neglected tropical diseases.

    Directory of Open Access Journals (Sweden)

    Sonia Pelletreau

    2011-11-01

    Full Text Available BACKGROUND: Vertical control and elimination programs focused on specific neglected tropical diseases (NTDs can achieve notable success by reducing the prevalence and intensity of infection. However, many NTD-endemic countries have not been able to launch or scale-up programs because they lack the necessary baseline data for planning and advocacy. Each NTD program has its own mapping guidelines to collect missing data. Where geographic overlap among NTDs exists, an integrated mapping approach could result in significant resource savings. We developed and field-tested an innovative integrated NTD mapping protocol (Integrated Threshold Mapping (ITM Methodology for lymphatic filariasis (LF, trachoma, schistosomiasis and soil-transmitted helminths (STH. METHODOLOGY/PRINCIPAL FINDINGS: The protocol is designed to be resource-efficient, and its specific purpose is to determine whether a threshold to trigger public health interventions in an implementation unit has been attained. The protocol relies on World Health Organization (WHO recommended indicators in the disease-specific age groups. For each disease, the sampling frame was the district, but for schistosomiasis, the sub-district rather than the ecological zone was used. We tested the protocol by comparing it to current WHO mapping methodologies for each of the targeted diseases in one district each in Mali and Senegal. Results were compared in terms of public health intervention, and feasibility, including cost. In this study, the ITM methodology reached the same conclusions as the WHO methodologies regarding the initiation of public health interventions for trachoma, LF and STH, but resulted in more targeted intervention recommendations for schistosomiasis. ITM was practical, feasible and demonstrated an overall cost saving compared with the standard, non-integrated, WHO methodologies. CONCLUSIONS/SIGNIFICANCE: This integrated mapping tool could facilitate the implementation of much

  12. Employing think-aloud protocols and constructive interaction to test the usability of online library catalogues: A methodological comparison

    NARCIS (Netherlands)

    Van Den Haak, M. J.; De Jong, M. D T; Schellens, P. J.

    2004-01-01

    This paper describes a comparative study of three usability test approaches: concurrent think-aloud protocols, retrospective think-aloud protocols, and constructive interaction. These three methods were compared by means of an evaluation of an online library catalogue, which involved four points of

  13. Employing think-aloud protocols and constructive interaction to test the usability of online library catalogues: a methodological comparison.

    NARCIS (Netherlands)

    van den Haak, M.J.; de Jong, Menno D.T.; Schellens, P.J.

    2004-01-01

    This paper describes a comparative study of three usability test approaches: concurrent think-aloud protocols, retrospective think-aloud protocols, and constructive interaction. These three methods were compared by means of an evaluation of an online library catalogue, which involved four points of

  14. Univariate Tests for Phase Capacity: Tools for Identifying When to Modify a Survey’s Data Collection Protocol

    Directory of Open Access Journals (Sweden)

    Lewis Taylor

    2017-09-01

    Full Text Available To mitigate the potentially harmful effects of nonresponse, most surveys repeatedly follow up with nonrespondents, often targeting a response rate or predetermined number of completes. Each additional recruitment attempt generally brings in a new wave of data, but returns gradually diminish over the course of a fixed data collection protocol, as each subsequent wave tends to consist of fewer responses than the last. Consequently, point estimates begin to stabilize. This is the notion of phase capacity, suggesting some form of design change is in order, such as switching modes, increasing the incentive, or, as is considered exclusively in this research, discontinuing the nonrespondent follow-up campaign altogether. A previously proposed test for phase capacity calls for multiply imputing nonrespondents’ missing data to assess, retrospectively, whether the most recent wave of data significantly altered a key, nonresponse-adjusted point estimate. This study introduces a more flexible adaptation amenable to surveys that instead reweight the observed data to compensate for nonresponse. Results from a simulation study and application indicate that, all else equal, the weighting version of the test is more sensitive to point estimate changes, thereby dictating more follow-up attempts are warranted.

  15. Protocol for production of a chewable material for masticatory function tests (Optocal - Brazilian version

    Directory of Open Access Journals (Sweden)

    Rafael de Liz Pocztaruk

    2008-12-01

    Full Text Available The present article aimed to present a standardized protocol for the production of a chewable test material that has been used in masticatory efficiency and performance studies. This chewable material has advantages in respect to its physical properties when compared to other artificial and natural test foods. It is constituted by mixing condensation silicon (58.3% by weight, common plaster (10.2% by weight, alginate (12.5% by weight, solid vaseline (11.5% by weight, tooth paste (7.5% by weight, and catalyst paste (20.8 mg/g, adding also three drops of mint essence. The mixed material is then inserted into an acrylic mould with perforations of 12 mm in diameter and 5 mm in height to produce rounded tablets with those measures after polymerization. It was named "Optocal - Brazilian version". A volume of 3 cm³ is indicated for a chewing test, which corresponds to 12 tablets using the present methodology. The present protocol can make the production of this chewable material easier, helping in its standardization for studies on masticatory function.

  16. Development of a comprehensive performance-testing protocol for competitive surfers.

    Science.gov (United States)

    Sheppard, Jeremy M; Nimphius, Sophia; Haff, Greg G; Tran, Tai T; Spiteri, Tania; Brooks, Hedda; Slater, Gary; Newton, Robert U

    2013-09-01

    Appropriate and valid testing protocols for evaluating the physical performances of surfing athletes are not well refined. The purpose of this project was to develop, refine, and evaluate a testing protocol for use with elite surfers, including measures of anthropometry, strength and power, and endurance. After pilot testing and consultation with athletes, coaches, and sport scientists, a specific suite of tests was developed. Forty-four competitive junior surfers (16.2 ± 1.3 y, 166.3 ± 7.3 cm, 57.9 ± 8.5 kg) participated in this study involving a within-day repeated-measures analysis, using an elite junior group of 22 international competitors (EJG), to establish reliability of the measures. To reflect validity of the testing measures, a comparison of performance results was then undertaken between the EJG and an age-matched competitive junior group of 22 nationally competitive surfers (CJG). Percent typical error of measurement (%TEM) for primary variables gained from the assessments ranged from 1.1% to 3.0%, with intraclass correlation coefficients ranging from .96 to .99. One-way analysis of variance revealed that the EJG had lower skinfolds (P = .005, d = 0.9) than the CJG, despite no difference in stature (P = .102) or body mass (P = .827). The EJG were faster in 15-m sprint-paddle velocity (P < .001, d = 1.3) and had higher lower-body isometric peak force (P = .04, d = 0.7) and superior endurance-paddling velocity (P = .008, d = 0.9). The relatively low %TEM of these tests in this population allows for high sensitivity to detect change. The results of this study suggest that competitively superior junior surfers are leaner and possess superior strength, paddling power, and paddling endurance.

  17. DC-10 composite vertical stabilizer ground test program

    Science.gov (United States)

    Palmer, J. M., Jr.; Stephens, C. O.; Sutton, J. O.

    1983-01-01

    A review of the structural configuration and ground test program is presented. Particular emphasis is placed on the testing of a full-scale stub box test subcomponent and full span ground test unit. The stub box subcomponent was tested in an environmental chamber under ambient, cold/wet, and hot/wet conditions. The test program included design limit static loads, fatigue spectrum loading to approximately two service lifetimes (with and without damage), design limit damage tolerance tests, and a final residual strength test to a structural failure. The first full-scale ground test unit was tested under ambient conditions. The test unit was to have undergone static, fatigue, and damage tolerance tests but a premature structural failure occurred at design limit load during the third limit load test. A failure theory was developed which explains the similarity in types of failure and the large load discrepancy at failure between the two test articles. The theory attributes both failures to high stress concentrations at the edge of the lower rear spar access opening. A second full-scale ground test unit has been modified to incorporate the various changes resulting from the premature failure. The article has been assembled and is active in the test program.

  18. Operational stability prediction in milling based on impact tests

    Science.gov (United States)

    Kiss, Adam K.; Hajdu, David; Bachrathy, Daniel; Stepan, Gabor

    2018-03-01

    Chatter detection is usually based on the analysis of measured signals captured during cutting processes. These techniques, however, often give ambiguous results close to the stability boundaries, which is a major limitation in industrial applications. In this paper, an experimental chatter detection method is proposed based on the system's response for perturbations during the machining process, and no system parameter identification is required. The proposed method identifies the dominant characteristic multiplier of the periodic dynamical system that models the milling process. The variation of the modulus of the largest characteristic multiplier can also be monitored, the stability boundary can precisely be extrapolated, while the manufacturing parameters are still kept in the chatter-free region. The method is derived in details, and also verified experimentally in laboratory environment.

  19. Modality determines VO2max achieved in self-paced exercise tests: validation with the Bruce protocol.

    Science.gov (United States)

    Hanson, Nicholas J; Scheadler, Cory M; Lee, Taylor L; Neuenfeldt, Noah C; Michael, Timothy J; Miller, Michael G

    2016-07-01

    The Bruce protocol is traditionally used to assess maximal cardiorespiratory fitness (VO2max), but may have limitations, such as an unknown duration and large work rate increases. The use of self-paced VO2max tests (SPVs) may be beneficial if they are able to elicit similar maximal values in a set period of time. In addition, differences in modality between SPVs have not been explored. The purpose of this study was to compare SPVs, utilizing two different modes, with the Bruce (treadmill) protocol. Thirteen healthy, recreationally active individuals (eight men, five women) volunteered and participated in three different laboratory visits with each utilizing a different VO2max testing protocol. The first visit consisted of the Bruce protocol test, and the remaining visits entailed a maximal SPV on a treadmill (TM SPV) and a cycle ergometer (CE SPV). There were no differences in VO2max values between the TM SPV and the Bruce protocol tests (55.6 ± 4.9 vs. 56.2 ± 6.8, respectively; p = .510). As expected, the CE SPV (48.3 ± 7.6) was significantly lower than the other two tests (p Bruce protocol and did so with less incline and in less time suggesting that there are no changes in the limits of VO2max even when the test is self-paced and perceptually regulated.

  20. The Use of Dynamic Visual Acuity as a Functional Test of Gaze Stabilization Following Space Flight

    Science.gov (United States)

    Peters, B. T.; Mulavara, A. P.; Brady, R.; Miller, C. A.; Richards, J. T.; Warren, L. E.; Cohen, H. S.; Bloomberg, J. J.

    2006-01-01

    After prolonged exposure to a given gravitational environment the transition to another is accompanied by adaptations in the sensorimotor subsystems, including the vestibular system. Variation in the adaptation time course of these subsystems, and the functional redundancies that exist between them make it difficult to accurately assess the functional capacity and physical limitations of astro/cosmonauts using tests on individual subsystems. While isolated tests of subsystem performance may be the only means to address where interventions are required, direct measures of performance may be more suitable for assessing the operational consequences of incomplete adaptation to changes in the gravitational environment. A test of dynamic visual acuity (DVA) is currently being used in the JSC Neurosciences Laboratory as part of a series of measures to assess the efficacy of a countermeasure to mitigate postflight locomotor dysfunction. In the current protocol, subjects visual acuity is determined using Landolt ring optotypes presented sequentially on a computer display. Visual acuity assessments are made both while standing and while walking at 1.8 m/s on a motorized treadmill. The use of a psychophysical threshold detection algorithm reduces the required number of optotype presentations and the results can be presented immediately after the test. The difference between the walking and standing acuity measures provides a metric of the change in the subject s ability to maintain gaze fixation on the visual target while walking. This functional consequence is observable regardless of the underlying subsystem most responsible for the change. Data from 15 cosmo/astronauts have been collected following long-duration (approx. 6 months) stays in space using a visual target viewing distance of 4.0 meters. An investigation of the group mean shows a change in DVA soon after the flight that asymptotes back to baseline approximately one week following their return to earth. The

  1. Health Worker Compliance with a ‘Test And Treat’ Malaria Case Management Protocol in Papua New Guinea

    Science.gov (United States)

    Pulford, Justin; Smith, Iso; Mueller, Ivo; Siba, Peter M.; Hetzel, Manuel W.

    2016-01-01

    The Papua New Guinea (PNG) Department of Health introduced a ‘test and treat’ malaria case management protocol in 2011. This study assesses health worker compliance with the test and treat protocol on a wide range of measures, examines self-reported barriers to health worker compliance as well as health worker attitudes towards the test and treat protocol. Data were collected by cross-sectional survey conducted in randomly selected primary health care facilities in 2012 and repeated in 2014. The combined survey data included passive observation of current or recently febrile patients (N = 771) and interviewer administered questionnaires completed with health workers (N = 265). Across the two surveys, 77.6% of patients were tested for malaria infection by rapid diagnostic test (RDT) or microscopy, 65.6% of confirmed malaria cases were prescribed the correct antimalarials and 15.3% of febrile patients who tested negative for malaria infection were incorrectly prescribed an antimalarial. Overall compliance with a strictly defined test and treat protocol was 62.8%. A reluctance to test current/recently febrile patients for malaria infection by RDT or microscopy in the absence of acute malaria symptoms, reserving recommended antimalarials for confirmed malaria cases only and choosing to clinically diagnose a malaria infection, despite a negative RDT result were the most frequently reported barriers to protocol compliance. Attitudinal support for the test and treat protocol, as assessed by a nine-item measure, improved across time. In conclusion, health worker compliance with the full test and treat malaria protocol requires improvement in PNG and additional health worker support will likely be required to achieve this. The broader evidence base would suggest any such support should be delivered over a longer period of time, be multi-dimensional and multi-modal. PMID:27391594

  2. Revisiting test stability: further evidence relating to the measurement ...

    African Journals Online (AJOL)

    In several earlier analyses of two tests of academic literacy – the Test of Academic Literacy Levels (TALL) and its Afrikaans counterpart, the Toets vir Akademiese Geletterdheidsvlakke (TAG) – we have adopted an approach to the problem that tests may be abused (and therefore used to harm people) by discussing various ...

  3. Surface stability and small-scale testing of zirconia

    OpenAIRE

    Camposilvan, Erik

    2015-01-01

    Tesi per compendi de publicacions. La consulta íntegra de la tesi, inclosos els articles no comunicats públicament per drets d'autor, es pot realitzar prèvia petició a l'Arxiu UPC Tetragonal polycrystalline zirconia stabilized with 3 mol% of yttria (3Y-TZP) is a biocompatible ceramic showing superior mechanical properties, which are partly the consequence of phase transformation: the tetragonal metastable phase can transform, with a net volume increase, to the stable monoclinic phase by a ...

  4. Testing the efficiency of rover science protocols for robotic sample selection: A GeoHeuristic Operational Strategies Test

    Science.gov (United States)

    Yingst, R. A.; Bartley, J. K.; Chidsey, T. C.; Cohen, B. A.; Gilleaudeau, G. J.; Hynek, B. M.; Kah, L. C.; Minitti, M. E.; Williams, R. M. E.; Black, S.; Gemperline, J.; Schaufler, R.; Thomas, R. J.

    2018-05-01

    The GHOST field tests are designed to isolate and test science-driven rover operations protocols, to determine best practices. During a recent field test at a potential Mars 2020 landing site analog, we tested two Mars Science Laboratory data-acquisition and decision-making methods to assess resulting science return and sample quality: a linear method, where sites of interest are studied in the order encountered, and a "walkabout-first" method, where sites of interest are examined remotely before down-selecting to a subset of sites that are interrogated with more resource-intensive instruments. The walkabout method cost less time and fewer resources, while increasing confidence in interpretations. Contextual data critical to evaluating site geology was acquired earlier than for the linear method, and given a higher priority, which resulted in development of more mature hypotheses earlier in the analysis process. Combined, this saved time and energy in the collection of data with more limited spatial coverage. Based on these results, we suggest that the walkabout method be used where doing so would provide early context and time for the science team to develop hypotheses-critical tests; and that in gathering context, coverage may be more important than higher resolution.

  5. Comparison of low back mobility and stability exercises from Pilates in non-specific low back pain: A study protocol of a randomized controlled trial.

    Science.gov (United States)

    Miranda, Iã Ferreira; Souza, Catiane; Schneider, Alexandre Tavares; Chagas, Leandro Campos; Loss, Jefferson Fagundes

    2018-05-01

    There is some evidence in the literature about the effectiveness of the Pilates methods in the low back pain. Moreover, Pilates focus on exercises that empathizes the stability and/or mobility of the spine. Therefore, it is discussed in the literature whether higher levels of stability or mobility of the lumbar spine generates better results, both in performance and rehabilitation for low back pain. Compare the effects of the low back mobility and stability exercises from Pilates Method on low back pain, disability and movement functionality in individuals with non-specific chronic low back pain. 28 participants will be randomized into two exercise protocol from Pilates methods, one focusing on low back stability and other on low back mobility. Low back pain (visual analogic scale), low back disability (Oswestry) and movement functionality (7 functional movement tasks) will be evaluated before and after 10 sessions of Pilates exercise by the same trained assessor. A mixed designed ANOVA with two factors will be used. This study is the first to compare these outcomes for chronic low back pain participants with two exercises protocol focusing on low back mobility and stability and the results will evaluate what to prioritize with Pilates exercises to give better results for that population. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Absorbable energy monitoring scheme: new design protocol to test vehicle structural crashworthiness

    Directory of Open Access Journals (Sweden)

    Sunday M. Ofochebe

    2016-05-01

    Full Text Available In vehicle crashworthiness design optimization detailed system evaluation capable of producing reliable results are basically achieved through high-order numerical computational (HNC models such as the dynamic finite element model, mesh-free model etc. However the application of these models especially during optimization studies is basically challenged by their inherent high demand on computational resources, conditional stability of the solution process, and lack of knowledge of viable parameter range for detailed optimization studies. The absorbable energy monitoring scheme (AEMS presented in this paper suggests a new design protocol that attempts to overcome such problems in evaluation of vehicle structure for crashworthiness. The implementation of the AEMS involves studying crash performance of vehicle components at various absorbable energy ratios based on a 2DOF lumped-mass-spring (LMS vehicle impact model. This allows for prompt prediction of useful parameter values in a given design problem. The application of the classical one-dimensional LMS model in vehicle crash analysis is further improved in the present work by developing a critical load matching criterion which allows for quantitative interpretation of the results of the abstract model in a typical vehicle crash design. The adequacy of the proposed AEMS for preliminary vehicle crashworthiness design is demonstrated in this paper, however its extension to full-scale design-optimization problem involving full vehicle model that shows greater structural detail requires more theoretical development.

  7. 46 CFR 170.185 - Stability test preparations.

    Science.gov (United States)

    2010-10-01

    ... test: (a) The vessel must be as complete as practicable at the time of the test. (b) Each tank vessel...) The water depth at the mooring site must provide ample clearance against grounding. (e) Each mooring... that result in acceptable accuracy in calculating the center of gravity and displacement of the unit...

  8. Simple test for physical stability of cryogenic tank insulation

    Science.gov (United States)

    Rossello, D.

    1968-01-01

    Qualitative test determines the ability of insulation liners used on liquid hydrogen tanks to withstand stresses produced by the thermal shocks imparted to the insulation during tank filling and drainage. Test specimens are bonded to metal plates with a low thermal expansion coefficient and are immersed in liquid hydrogen.

  9. PEP Support: Laboratory Scale Leaching and Permeate Stability Tests

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.; Buchmiller, William C.

    2010-05-21

    This report documents results from a variety of activities requested by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). The activities related to caustic leaching, oxidative leaching, permeate precipitation behavior of waste as well as chromium (Cr) leaching are: • Model Input Boehmite Leaching Tests • Pretreatment Engineering Platform (PEP) Support Leaching Tests • PEP Parallel Leaching Tests • Precipitation Study Results • Cr Caustic and Oxidative Leaching Tests. Leaching test activities using the PEP simulant provided input to a boehmite dissolution model and determined the effect of temperature on mass loss during caustic leaching, the reaction rate constant for the boehmite dissolution, and the effect of aeration in enhancing the chromium dissolution during caustic leaching. Other tests were performed in parallel with the PEP tests to support the development of scaling factors for caustic and oxidative leaching. Another study determined if precipitate formed in the wash solution after the caustic leach in the PEP. Finally, the leaching characteristics of different chromium compounds under different conditions were examined to determine the best one to use in further testing.

  10. Laboratory testing protocol for the impact of dispersed petrochemicals on seagrass

    International Nuclear Information System (INIS)

    Wilson, K.G.; Ralph, P.J.

    2012-01-01

    Highlights: ► Seagrass were exposed to dispersed and non-dispersed crude and fuel oil. ► Dispersed oil led to significant reductions in photosynthetic health of seagrass. ► Non-dispersed oil resulted in only minor reductions in seagrass health. ► Testing protocol developed enables rapid comparisons of oil spill mitigation options. - Abstract: To improve the effectiveness of oil spill mitigation, we developed a rapid, logistically simple protocol to detect petrochemical stress on seagrass. Sections of leaf blades from Zostera muelleri subsp. capricorni were exposed to the water accommodated fraction (WAF) of non-dispersed and dispersed Tapis crude oil and fuel oil (IFO-380) for 5 h. Photosynthetic health was monitored by assessing changes in effective quantum yield of photosystem II (ΔF/F m ′ ) and chlorophyll a pigment concentrations. Loss of total petroleum hydrocarbons (TPH) was measured using an oil-in-water fluorometer, whilst GC–MS analyses quantified the hydrocarbon components within each treatment. Few significant differences were detected in the chlorophyll a pigment analyses; however, ΔF/F m ′ appeared sensitive to petrochemical exposure. Dispersing both types of oil resulted in a substantial increase in the TPH of the WAF and was generally correlated with a greater physiological impact to the seagrass health, compared with the oil alone.

  11. IMPROVED COMPUTATIONAL NEUTRONICS METHODS AND VALIDATION PROTOCOLS FOR THE ADVANCED TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Joseph W. Nielsen; Benjamin M. Chase; Ronnie K. Murray; Kevin A. Steuhm

    2012-04-01

    The Idaho National Laboratory (INL) is in the process of modernizing the various reactor physics modeling and simulation tools used to support operation and safety assurance of the Advanced Test Reactor (ATR). Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core depletion HELIOS calculations for all ATR cycles since August 2009 was successfully completed during 2011. This demonstration supported a decision late in the year to proceed with the phased incorporation of the HELIOS methodology into the ATR fuel cycle management process beginning in 2012. On the experimental side of the project, new hardware was fabricated, measurement protocols were finalized, and the first four of six planned physics code validation experiments based on neutron activation spectrometry were conducted at the ATRC facility. Data analysis for the first three experiments, focused on characterization of the neutron spectrum in one of the ATR flux traps, has been completed. The six experiments will ultimately form the basis for a flexible, easily-repeatable ATR physics code validation protocol that is consistent with applicable ASTM standards.

  12. Impact of using a local protocol in preoperative testing: blind randomized clinical trial.

    Science.gov (United States)

    Santos, Mônica Loureiro; Iglesias, Antônio Carlos

    2017-01-01

    to evaluate the impact of the use of a local protocol of preoperative test requests in reducing the number of exams requested and in the occurrence of changes in surgical anesthetic management and perioperative complications. we conducted a randomized, blinded clinical trial at the Gaffrée and Guinle University Hospital with 405 patients candidates for elective surgery randomly divided into two groups, according to the practice of requesting preoperative exams: a group with non-selectively requested exams and a protocol group with exams requested according to the study protocol. Studied exams: complete blood count, coagulogram, glycemia, electrolytes, urea and creatinine, ECG and chest X-ray. Primary outcomes: changes in surgical anesthetic management caused by abnormal exams, reduction of the number of exams requested after the use of the protocol and perioperative complications. there was a significant difference (pprotocolo local de solicitações de exames pré-operatórios na redução do número de exames solicitados e na ocorrência de alterações na conduta anestésico-cirúrgica e de complicações perioperatórias. ensaio clínico randomizado, cego, realizado no Hospital Universitário Gaffrée e Guinle com 405 pacientes candidatos à operação eletiva divididos randomicamente em dois grupos segundo a prática de solicitação de exames pré-operatórios: grupo Rotina com exames solicitados de maneira não seletiva e grupo Protocolo com exames solicitados de acordo com o protocolo em estudo. Exames em estudo: hemograma, coagulograma, glicemia, eletrólitos, ureia e creatinina, ECG e radiografia de tórax. Desfechos primários: alterações na conduta anestésico-cirúrgica motivadas por exames anormais, redução do número de exames solicitados após o uso do protocolo e complicações perioperatórias. foi observada diferença significativa (pprotocolo proposto foi efetivo em eliminar um quantitativo significativo de exames complementares sem indica

  13. Protocol for Usability Testing and Validation of the ISO Draft International Standard 19223 for Lung Ventilators

    Science.gov (United States)

    2017-01-01

    standardization in any given domain that involves equipment, multiple manufacturers, inconsistent vocabulary, symbology, audio tones, or patterns in interface navigation. Second, the protocol can be used to experimentally evaluate the ISO DIS 19223 for its effectiveness, as researchers around the world may wish to conduct such tests and compare results. PMID:28887292

  14. Which diagnostic tests are most useful in a chest pain unit protocol?

    Directory of Open Access Journals (Sweden)

    Arnold Jane

    2005-08-01

    Full Text Available Abstract Background The chest pain unit (CPU provides rapid diagnostic assessment for patients with acute, undifferentiated chest pain, using a combination of electrocardiographic (ECG recording, biochemical markers and provocative cardiac testing. We aimed to identify which elements of a CPU protocol were most diagnostically and prognostically useful. Methods The Northern General Hospital CPU uses 2–6 hours of serial ECG / ST segment monitoring, CK-MB(mass on arrival and at least two hours later, troponin T at least six hours after worst pain and exercise treadmill testing. Data were prospectively collected over an eighteen-month period from patients managed on the CPU. Patients discharged after CPU assessment were invited to attend a follow-up appointment 72 hours later for ECG and troponin T measurement. Hospital records of all patients were reviewed to identify adverse cardiac events over the subsequent six months. Diagnostic accuracy of each test was estimated by calculating sensitivity and specificity for: 1 acute coronary syndrome (ACS with clinical myocardial infarction and 2 ACS with myocyte necrosis. Prognostic value was estimated by calculating the relative risk of an adverse cardiac event following a positive result. Results Of the 706 patients, 30 (4.2% were diagnosed as ACS with myocardial infarction, 30 (4.2% as ACS with myocyte necrosis, and 32 (4.5% suffered an adverse cardiac event. Sensitivities for ACS with myocardial infarction and myocyte necrosis respectively were: serial ECG / ST segment monitoring 33% and 23%; CK-MB(mass 96% and 63%; troponin T (using 0.03 ng/ml threshold 96% and 90%. The only test that added useful prognostic information was exercise treadmill testing (relative risk 6 for cardiac death, non-fatal myocardial infarction or arrhythmia over six months. Conclusion Serial ECG / ST monitoring, as used in our protocol, adds little diagnostic or prognostic value in patients with a normal or non

  15. VALIDITY OF CRITICAL FREQUENCY TEST FOR MEASURING TABLE TENNIS AEROBIC ENDURANCE THROUGH SPECIFIC PROTOCOL

    Directory of Open Access Journals (Sweden)

    Alessandro M. Zagatto

    2008-12-01

    Full Text Available The aim of this study was to validate critical frequency specific test (critf for the estimation of the aerobic endurance in table tennis players. Methods: Eight male international-level table tennis players participated of this study. Specific tests were applied by using a mechanical ball thrower to control the intensity of the exercise. The critf was determined by applying three or four series of exercises to exhaustion (Tlim. The critf was evaluated by using lactate steady state test (90, 100, and 106 % of critf intensity. The other specific test was an incremental protocol used to determine the anaerobic threshold (AnTBI and the onset of blood lactate accumulation (OBLA using a ball thrower. Results: The critf (39.87 ± 3.31 balls·min-1 was not significantly different among AnTBI (48.11 ± 7.36 balls·min- 1 and OBLA3.5 (49.36 ± 12.04 balls·min-1 frequencies and it was correlated with AnTBI parameter (r = 0.78. At frequencies of the 90 and 100% of critf a dynamic equilibrium was verified in lactate concentration between the eighth and twentieth minutes. However, this dynamic equilibrium was not found at 106% intensity. Conclusion: The data indicate that in table tennis the critf model can be used for measuring the aerobic endurance

  16. Space shuttle maneuvering engine reusable thrust chamber program. Task 11: Low Epsilon stability test plan

    Science.gov (United States)

    Pauckert, R. P.

    1974-01-01

    The performance and heat transfer characteristics of a doublet element type injector for the space shuttle orbiter maneuvering engine thrust chamber were investigated. Ths stability characteristics were evaluated over a range of chamber pressures and mixture ratios. The specific objectives of the test were: (1) to determine whether stability has been influenced by injection of boundary layer coolant across the cavity entrance, (2) if the injector is stable, to determine the minimum cavity area required to maintain stability, and (3) if the injector is unstable, to determine the effects of entrance geometry and increased area on stability.

  17. Investigations of blood ammonia analysis: Test matrices, storage, and stability.

    Science.gov (United States)

    Goldstein, Brittany N; Wesler, Jordan; Nowacki, Amy S; Reineks, Edmunds; Natowicz, Marvin R

    2017-06-01

    An assessment of blood ammonia concentration is common medical practice in the evaluation of an individual with an unexplained mental status change or coma. The determination of a blood ammonia level is most commonly done using a glutamate dehydrogenase (GLDH)-based assay, although there are many potential sources of artifact and the literature is inconsistent regarding key preanalytic issues. Using a GLDH-based assay, we first investigated matrix effects using three anticoagulants: heparin, EDTA and oxalate. Heparin-anticoagulated plasma was substantially less precise than EDTA- and oxalate-anticoagulated plasma. Oxalate-anticoagulated plasma showed a greater baseline of apparent ammonia than either heparin- or EDTA-derived plasma, presumably due to interferants. We then evaluated the stability of EDTA-anticoagulated plasma for assessment of ammonia when stored at 4°C,-14°C or -70°C. There was a linear increase of ammonia with storage at both 4°C and -14°C. Plasma kept at -70°C for up to three weeks showed no change in measured ammonia relative to the baseline determination. This work clarifies preanalytic conditions for which a precise determination of ammonia can be accomplished using a GLDH-based assay. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  18. It's Time to Develop a New "Draft Test Protocol" for a Mars Sample Return Mission (or Two…).

    Science.gov (United States)

    Rummel, John D; Kminek, Gerhard

    2018-04-01

    The last time NASA envisioned a sample return mission from Mars, the development of a protocol to support the analysis of the samples in a containment facility resulted in a "Draft Test Protocol" that outlined required preparations "for the safe receiving, handling, testing, distributing, and archiving of martian materials here on Earth" (Rummel et al., 2002 ). This document comprised a specific protocol to be used to conduct a biohazard test for a returned martian sample, following the recommendations of the Space Studies Board of the US National Academy of Sciences. Given the planned launch of a sample-collecting and sample-caching rover (Mars 2020) in 2 years' time, and with a sample return planned for the end of the next decade, it is time to revisit the Draft Test Protocol to develop a sample analysis and biohazard test plan to meet the needs of these future missions. Key Words: Biohazard detection-Mars sample analysis-Sample receiving facility-Protocol-New analytical techniques-Robotic sample handling. Astrobiology 18, 377-380.

  19. Tube suction test for evaluating durability of cementitiously stabilized soils.

    Science.gov (United States)

    2011-06-01

    In a comprehensive laboratory study, different tests namely, unconfined compressive strength (UCS) at the end of freeze-thaw/wet-dry (F-T/W-D) cycles, resilient modulus (Mr) at the end of F-T/W-D cycles, vacuum saturation, tube suction, and moisture ...

  20. Environmental Stability Testing of a Coated, Elastomeric Dental Ribbon.

    Science.gov (United States)

    1979-09-01

    soe or " esa PWXZ S 16CURITV CLASIFICATION OF THIS PAGR(Ihusa t Eftmem percent) respectively.) Modulus were 5.0,0.18, 0.14 and 0.08 (xl05 p.s.i...lengths were measured with a steel ruler (to 0.01 inch). **Conditioning Specimens tested at temperatures above and below roo. temperature were conditioned

  1. Test of Cable Products in Respect of Thermal and Dynamic Stability

    Directory of Open Access Journals (Sweden)

    M. A. Коrotkevich

    2010-01-01

    Full Text Available The paper considers conditions for selection of  power supply of the unit which is used for testing samples of cable products by thermal and dynamic stability currents. It has been shown that while conducting testing by thermal and dynamic stability currents at nominal cable voltage it is more justifiable to use a percussive energy accumulator, and in the case when the voltage is low an inductive energy accumulator is used.

  2. A Protocol of Manual Tests to Measure Sensation and Pain in Humans.

    Science.gov (United States)

    Kostek, Matthew; Polaski, Anna; Kolber, Benedict; Ramsey, Austin; Kranjec, Alexander; Szucs, Kimberly

    2016-12-19

    Numerous qualitative and quantitative techniques can be used to test sensory nerves and pain in both research and clinical settings. The current study demonstrates a quantitative sensory testing protocol using techniques to measure tactile sensation and pain threshold for pressure and heat using portable and easily accessed equipment. These techniques and equipment are ideal for new laboratories and clinics where cost is a concern or a limiting factor. We demonstrate measurement techniques for the following: cutaneous mechanical sensitivity on the arms and legs (von-Frey filaments), radiant and contact heat sensitivity (with both threshold and qualitative assessments using the Visual Analog Scale (VAS)), and mechanical pressure sensitivity (algometer, with both threshold and the VAS). The techniques and equipment described and demonstrated here can be easily purchased, stored, and transported by most clinics and research laboratories around the world. A limitation of this approach is a lack of automation or computer control. Thus, these processes can be more labor intensive in terms of personnel training and data recording than the more sophisticated equipment. We provide a set of reliability data for the demonstrated techniques. From our description, a new laboratory should be able to set up and run these tests and to develop their own internal reliability data.

  3. Leader-Following Consensus Stability of Discrete-Time Linear Multiagent Systems with Observer-Based Protocols

    Directory of Open Access Journals (Sweden)

    Bingbing Xu

    2013-01-01

    Full Text Available We consider the leader-following consensus problem of discrete-time multiagent systems on a directed communication topology. Two types of distributed observer-based consensus protocols are considered to solve such a problem. The observers involved in the proposed protocols include full-order observer and reduced-order observer, which are used to reconstruct the state variables. Two algorithms are provided to construct the consensus protocols, which are based on the modified discrete-time algebraic Riccati equation and Sylvester equation. In light of graph and matrix theory, some consensus conditions are established. Finally, a numerical example is provided to illustrate the obtained result.

  4. Testing the effect of a microbial-based soil amendment on aggregate stability and erodibility

    DEFF Research Database (Denmark)

    Malozo, Mponda; Iversen, Bo Vangsø; Heckrath, Goswin Johann

    Minimizing soil erosion is essential for maintaining proper soil quality and thus preserving soil productivity. The erodibility of a soil is closely linked to its structural stability as well as its infiltrability. This study focuses on testing the effect of two different soil amendments on soil...... aggregate stability and erodibility. Two commercial products, gypsum and a microbial-based solution were used for the experiment and were tested on two Danish sandy loamy soils as well on a sandy soil from Tanzania. The carrier of the microbial-based product, a glycerol solution, was tested as well....... In the laboratory, soils were treated with the soil amendments in a two-step procedure at controlled water contents following aerobic incubation in closed containers. Water-aggregate stability and clay dispersion were measured on soil aggregates less than 8 mm in diameter. Aggregate stability was measured...

  5. Performance of the Immediate Post-Concussion Assessment and Cognitive Testing Protocol Validity Indices.

    Science.gov (United States)

    Manderino, L M; Gunstad, J

    2017-10-27

    Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a computerized neuropsychological test battery. Athletes provide preseason baseline ImPACT scores to which post-injury scores can be compared to aid concussion diagnosis. However, if baseline scores are not accurately representative of abilities, the utility of post-injury score comparison is diminished. For this reason, ImPACT includes low score thresholds on five validity indices to identify insufficient effort at baseline, though evidence of these indices' performance is limited. The present study examines the classification accuracy and concurrent validity of the existing ImPACT validity indices and three proposed indices (Word Memory Correct Distractors, Design Memory Correct Distractors, Total Symptom Score). The ImPACT, Word Memory Test (WMT) and Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) were administered to 242 undergraduate students. Participants were instructed to either give full effort on testing or to simulate SRC. Sensitivity of the existing ImPACT validity indices was marginally improved with adjusted score thresholds while maintaining acceptable specificity (0.90). Alternative score thresholds and novel validity indices demonstrated adequate specificity while improving sensitivity overall. Positive and negative predictive powers are provided to inform use of protocol validity indices across diverse treatment settings. The existing ImPACT indices' high specificity at the expense of lower sensitivity compared to external validity measures may under-identify poor effort, resulting in premature return-to-play decisions for athletes with concussion. Improvements or additions to the existing indices may raise sensitivity while maintaining acceptable specificity, aiding in the protection of athletes and safe athletic participation. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. PEP Support Laboratory Leaching and Permeate Stability Tests

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.; Buchmiller, William C.

    2009-09-25

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed, and operated as part of a plan to respond to issue M12, "Undemonstrated Leaching Processes," of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. A simplified flow diagram of the PEP system is shown in Figure 1.1. Two operating scenarios are currently being evaluated for the ultrafiltration process (UFP) and leaching operations. The first scenario has caustic leaching performed in the UFP-2 ultrafiltration feed vessels (i.e., vessel UFP-VSL-T02A in the PEP and vessels UFP-VSL-00002A and B in the WTP PTF). The second scenario has caustic leaching conducted in the UFP-1 ultrafiltration feed preparation vessels (i.e., vessels UFP-VSL-T01A and B in the PEP and vessels UFP-VSL-00001A and B in the WTP PTF). In both scenarios, 19-M sodium hydroxide solution (NaOH, caustic) is added to the waste slurry in the vessels to leach solid aluminum compounds (e.g., gibbsite, boehmite). Caustic addition is followed by a heating step that uses direct injection of steam to accelerate the leach process. Following the caustic leach, the vessel contents are cooled using vessel cooling jackets and/or external heat exchangers. The main difference between the two scenarios is that for leaching in UFP-VSL-T01A and B, the 19-M NaOH is added to un-concentrated waste slurry (3 to 8 wt% solids), while for leaching in

  7. Centrifugation protocols: tests to determine optimal lithium heparin and citrate plasma sample quality.

    Science.gov (United States)

    Dimeski, Goce; Solano, Connie; Petroff, Mark K; Hynd, Matthew

    2011-05-01

    Currently, no clear guidelines exist for the most appropriate tests to determine sample quality from centrifugation protocols for plasma sample types with both lithium heparin in gel barrier tubes for biochemistry testing and citrate tubes for coagulation testing. Blood was collected from 14 participants in four lithium heparin and one serum tube with gel barrier. The plasma tubes were centrifuged at four different centrifuge settings and analysed for potassium (K(+)), lactate dehydrogenase (LD), glucose and phosphorus (Pi) at zero time, poststorage at six hours at 21 °C and six days at 2-8°C. At the same time, three citrate tubes were collected and centrifuged at three different centrifuge settings and analysed immediately for prothrombin time/international normalized ratio, activated partial thromboplastin time, derived fibrinogen and surface-activated clotting time (SACT). The biochemistry analytes indicate plasma is less stable than serum. Plasma sample quality is higher with longer centrifugation time, and much higher g force. Blood cells present in the plasma lyse with time or are damaged when transferred in the reaction vessels, causing an increase in the K(+), LD and Pi above outlined limits. The cells remain active and consume glucose even in cold storage. The SACT is the only coagulation parameter that was affected by platelets >10 × 10(9)/L in the citrate plasma. In addition to the platelet count, a limited but sensitive number of assays (K(+), LD, glucose and Pi for biochemistry, and SACT for coagulation) can be used to determine appropriate centrifuge settings to consistently obtain the highest quality lithium heparin and citrate plasma samples. The findings will aid laboratories to balance the need to provide the most accurate results in the best turnaround time.

  8. Validity of the modified back-saver sit-and-reach test: a comparison with other protocols.

    Science.gov (United States)

    Hui, S S; Yuen, P Y

    2000-09-01

    Studies have shown that the classical sit-and-reach (CSR) test, the modified sit-and-reach (MSR), and the newly developed back-saver sit-and-reach (BS) test have poor criterion-related validity in estimating low-back flexibility but yielded moderate criterion-related validity in hamstring flexibility. The V sit-and-reach (VSR) test was found to be practical but the validity has not been established. The purpose of this study was to propose a modified back-saver sit-and-reach (MBS) test, which incorporated all advantages of the various protocols, and to compare the criterion-related validity and reliability of all these tests. 158 college students (F = 96, and M = 62; age = 20.77 +/- 2.51) performed CSR, VSR, BS (left and right leg), and MBS (left and right leg) tests in a randomized order. Scores from each test were then correlated with the criterion measures. For all sit-reach tests, intraclass reliability (single trial) was very high (r = 0.89-0.98). MBS yielded significant and highest r with low-back and hamstring criterion for men (r = 0.47-0.67) and women (r = 0.23-0.54). The low-back and right hamstring validity of MBS for men were significantly (P sit-and-reach protocols were significantly different (P test as compared with other protocols. The MBS test is not only a reliable test for hamstring and low-back flexibility, it is also a more practical with improved validity for hamstring and low-back flexibility in men than previous protocols.

  9. Thermal Stability Test of Sugar Alcohols as Phase Change Materials for Medium Temperature Energy Storage Application

    OpenAIRE

    Solé, Aran; Neumann, Hannah; Niedermaier, Sophia; Cabeza, Luisa F.; Palomo, Elena

    2014-01-01

    Sugar alcohols are potential phase change materials candidates as they present high phase change enthalpy values, are non-toxic and low cost products. Three promising sugar-alcohols were selected: D-mannitol, myo-inositol and dulcitol under high melting enthalpy and temperature criterion. Thermal cycling tests were performed to study its cycling stability which can be determining when selecting the suitable phase change material. D-mannitol and dulcitol present poor thermal stability...

  10. Data Fusion Modeling for an RT3102 and Dewetron System Application in Hybrid Vehicle Stability Testing

    OpenAIRE

    Zhibin Miao; Hongtian Zhang

    2015-01-01

    More and more hybrid electric vehicles are driven since they offer such advantages as energy savings and better active safety performance. Hybrid vehicles have two or more power driving systems and frequently switch working condition, so controlling stability is very important. In this work, a two-stage Kalman algorithm method is used to fuse data in hybrid vehicle stability testing. First, the RT3102 navigation system and Dewetron system are introduced. Second, a modeling of data fusion is p...

  11. Stability of FDG-PET Radiomics features - An integrated analysis of test-retest and inter-observer variability

    Energy Technology Data Exchange (ETDEWEB)

    Leijenaar, Ralph T. H.; Carvalho, Sara; Rios Velazquez, Emmanuel [Dept. of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht Univ. Medical Center, Maastricht (Netherlands)] [and others

    2013-10-15

    Purpose: Besides basic measurements as maximum standardized uptake value (SUV){sub max} or SUV{sub mean} derived from 18F-FDG positron emission tomography (PET) scans, more advanced quantitative imaging features (i.e. 'Radiomics' features) are increasingly investigated for treatment monitoring, outcome prediction, or as potential biomarkers. With these prospected applications of Radiomics features, it is a requisite that they provide robust and reliable measurements. The aim of our study was therefore to perform an integrated stability analysis of a large number of PET-derived features in non-small cell lung carcinoma (NSCLC), based on both a test-retest and an inter-observer setup. Methods: Eleven NSCLC patients were included in the test-retest cohort. Patients underwent repeated PET imaging within a one day interval, before any treatment was delivered. Lesions were delineated by applying a threshold of 50 % of the maximum uptake value within the tumor. Twenty-three NSCLC patients were included in the inter-observer cohort. Patients underwent a diagnostic whole body PET-computed tomography (CT). Lesions were manually delineated based on fused PET-CT, using a standardized clinical delineation protocol. Delineation was performed independently by five observers, blinded to each other. Fifteen first order statistics, 39 descriptors of intensity volume histograms, eight geometric features and 44 textural features were extracted. For every feature, test-retest and inter-observer stability was assessed with the intra-class correlation coefficient (ICC) and the coefficient of variability, normalized to mean and range. Similarity between test-retest and inter-observer stability rankings of features was assessed with Spear man's rank correlation coefficient. Results: Results showed that the majority of assessed features had both a high test-retest (71%) and inter-observer (91%) stability in terms of their ICC. Overall, features more stable in repeated PET

  12. Field Demonstration, Optimization, and Rigorous Validation of Peroxygen-Based ISCO for the Remediation of Contaminated Groundwater - CHP Stabilization Protocol

    Science.gov (United States)

    2014-05-01

    hydrogen peroxide decomposition in systems catalyzed by naturally occurring iron minerals, resulting in more effective treatment stoichiometry ( Tyre ...Hydrogen Peroxide Lifetimes in Systems under Different Conditions of Stabilization Using 4 mL Hydrogen Peroxide Solution/30 g of Subsurface Solids...86 Table 4-16. TPH Destruction in Systems under Different Conditions of Stabilization Using 4 mL Hydrogen

  13. A Novel Amphibian Tier 2 Testing Protocol: A 30-Week Exposure of Xenopus Tropicalis to the Antiandrogen Flutamide

    National Research Council Canada - National Science Library

    Knechtges, Paul L; Sprando, Robert L; Porter, Karen L; Brennan, Linda M; Miller, Mark F; Kumsher, David M; Dennis, William E; Brown, Charles C; Clegg Paul L. Knechtges. Robert L. Sprando. Karen L. Potter., Eric D

    2007-01-01

    .... For that reason, a tier 2 testing protocol using Xenopus (Silurana) tropicalis and a 30-week, flow-through exposure to the antiandrogen flutamide from stage 46 tadpoles through sexually mature adult frogs were developed and evaluated in this pilot study...

  14. Comparing Motor Control Exercise and General Exercise on Lumbo-Pelvic Stability of Chronic Nonspecific Low Back Pain Sufferers Using Endurance Stability Tests

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Shamsi

    2018-01-01

    Conclusion Though it is claimed that MCE increases spinal stability, the lack of significant difference in the results of variables between the two groups may be due to our MCE not being specific for increasing spinal stability or equal effects of both interventions on increasing spinal stability and no preference of MCE. It may also be due to poor sensitivity of our outcome measures in detecting changes in spinal stability, especially with respect to the sample size. Based on these results, it could be concluded that MCE is not more effective than GE in improving endurance core stability tests and reducing disability and pain in chronic non-specific LBP patients.

  15. Proposal of methodology and test protocol for evaluating and qualifying pH measuring devices

    Directory of Open Access Journals (Sweden)

    Niza Helena de Almeida

    2006-01-01

    Full Text Available We present a proposal for evaluating and qualifying pH measuring devices based on the requirements of relevant standards. The proposal presented is based on ASTM E70, NBR 7353, JIS Z 8805, BS 3145, DIN 19268, NBR ISO 17025 and other standards, as well as the results of field research carried out in conjunction with professionals performing pH measurements in public health laboratories. Evaluation is performed by inspection of a form which records data from the measuring system. The form gives acceptable variations in the parameters being tested and allows a conclusion to be reached regarding acceptability of the system. Using the proposed protocol allows definition of suitable analysis criteria, while taking into account the influence pH measurement is subject and the need for correct results. This is particularly true when analyzing products already on the market, thus underlining the protocol's importance to the public health area.Este artigo apresenta uma proposta de protocolo de avaliação e qualificação de medidores de pH fundamentada no que prescrevem as normas ASTM E 70, NBR 7353, JIS Z 8805, BS 3145, DIN 19268, NBR ISO 17025 e outras, complementada com os resultados de pesquisa de campo junto a profissionais que realizam ensaio de medição de pH em laboratórios de saúde pública. A proposta consiste em avaliar o medidor de pH com auxílio de um formulário, cujo preenchimento baseia-se, principalmente, na inspeção e ensaios no sistema medidor. O formulário fornece variações aceitáveis para os parâmetros testados, propiciando parecer conclusivo quanto à adequação do instrumento. A aplicação do protocolo permite definir um critério adequado de análise, tendo em vista a influência que sofre tal ensaio de medição, especialmente, em análises de amostras de produtos decorrentes de finalidade fiscal, no âmbito da saúde pública

  16. Does core stability exercise improve lumbopelvic stability (through endurance tests) more than general exercise in chronic low back pain? A quasi-randomized controlled trial.

    Science.gov (United States)

    Shamsi, Mohammad Bagher; Rezaei, Mandana; Zamanlou, Mehdi; Sadeghi, Mehdi; Pourahmadi, Mohammad Reza

    2016-01-01

    The aim was to compare core stability and general exercises (GEs) in chronic low back pain (LBP) patients based on lumbopelvic stability (LPS) assessment through three endurance core stability tests. There is a controversy about preference of core stability exercise (CSE) over other types of exercise for chronic LBP. Studies which have compared these exercises used other outcomes than those related to LPS. As it is claimed that CSE enhances back stability, endurance tests for LPS were used. A 16-session CSE program and a GE program with the same duration were conducted for two groups of participants. Frequency of interventions for both groups was three times a week. Forty-three people (aged 18-60 years) with chronic non-specific LBP were alternately allocated to core stability (n = 22) or GE group (n = 21) when admitted. The primary outcomes were three endurance core stability tests including: (1) trunk flexor; (2) trunk extensor; and (3) side bridge tests. Secondary outcomes were disability and pain. Measurements were taken at baseline and the end of the intervention. After the intervention, test times increased and disability and pain decreased within groups. There was no significant difference between two groups in increasing test times (p = 0.23 to p = 0.36) or decreasing disability (p = 0.16) and pain (p = 0.73). CSE is not more effective than GE for improving endurance core stability tests and reducing disability and pain in chronic non-specific LBP patients.

  17. Hover test of a full-scale hingeless helicopter rotor: Aeroelastic stability, performance and loads data. [wind tunnel tests

    Science.gov (United States)

    Peterson, R. L.; Warmbrodt, W.

    1984-01-01

    A hover test of a full-scale, hingeless rotor system was conducted in the NASA Ames 40- by 80-foot wind tunnel. The rotor was tested on the Ames rotor test apparatus. Rotor aeroelastic stability, performance, and loads at various rotational speeds and thrust coefficients were investigated. The primary objective was to determine the inplane stability characteristics of the rotor system. Rotor inplane damping data were obtained for operation between 350 and 425 rpm (design speed), and for thurst coefficients between 0.0 and 0.12. The rotor was stable for all conditions tested. At constant rotor rotational speed, a minimum inplane dampling level was obtained at a thrust coefficient approximately = 0.02. At constant rotor lift, a minimum in rotor inplane damping was measured at 400 rpm.

  18. Slope stability and bearing capacity of landfills and simple on-site test methods.

    Science.gov (United States)

    Yamawaki, Atsushi; Doi, Yoichi; Omine, Kiyoshi

    2017-07-01

    This study discusses strength characteristics (slope stability, bearing capacity, etc.) of waste landfills through on-site tests that were carried out at 29 locations in 19 sites in Japan and three other countries, and proposes simple methods to test and assess the mechanical strength of landfills on site. Also, the possibility of using a landfill site was investigated by a full-scale eccentric loading test. As a result of this, landfills containing more than about 10 cm long plastics or other fibrous materials were found to be resilient and hard to yield. An on-site full scale test proved that no differential settlement occurs. The repose angle test proposed as a simple on-site test method has been confirmed to be a good indicator for slope stability assessment. The repose angle test suggested that landfills which have high, near-saturation water content have considerably poorer slope stability. The results of our repose angle test and the impact acceleration test were related to the internal friction angle and the cohesion, respectively. In addition to this, it was found that the air pore volume ratio measured by an on-site air pore volume ratio test is likely to be related to various strength parameters.

  19. Shortened screening method for phosphorus fractionation in sediments A complementary approach to the standards, measurements and testing harmonised protocol

    International Nuclear Information System (INIS)

    Pardo, Patricia; Rauret, Gemma; Lopez-Sanchez, Jose Fermin

    2004-01-01

    The SMT protocol, a sediment phosphorus fractionation method harmonised and validated in the frame of the standards, measurements and testing (SMT) programme (European Commission), establishes five fractions of phosphorus according to their extractability. The determination of phosphate extracted is carried out spectrophotometrically. This protocol has been applied to 11 sediments of different origin and characteristics and the phosphorus extracted in each fraction was determined not only by UV-Vis spectrophotometry, but also by inductively coupled plasma-atomic emission spectrometry. The use of these two determination techniques allowed the differentiation between phosphorus that was present in the extracts as soluble reactive phosphorus and as total phosphorus. From the comparison of data obtained with both determination techniques a shortened screening method, for a quick evaluation of the magnitude and importance of the fractions given by the SMT protocol, is proposed and validated using two certified reference materials

  20. Testing the WelFur assessment protocol for mink on-farm in three seasons of production

    DEFF Research Database (Denmark)

    Møller, Steen Henrik; Hansen, Steffen W

    2011-01-01

    Welfare Quality® seems to develop into a standard for farm animal welfare assessment and European Fur Breeders’ Association initiated the “WelFur” project in 2009 in order to develop a welfare assessment protocol for mink and fox farms after the WQ standards. The assessment is based on four...... to cover the life cycle of the mink. The final welfare assessment is categorised as: ’Excellent’, ’Above average’, ’Acceptable’ or ’Not classified’ according to the welfare score for each of the four principles. The protocols for the three seasons are being tested in several countries and the Danish...... results shows that the WelFur protocol is feasible for a one-day visit and sensible enough to discriminate between farms in the same category. A stratified sample of 120 cages seems to be sufficient. It is concluded that it is possible to assess the welfare in mink using the principles developed...

  1. Stability of selected volatile contact allergens in different patch test chambers under different storage conditions

    DEFF Research Database (Denmark)

    Mose, Kristian Fredløv; Andersen, Klaus Ejner; Christensen, Lars Porskjaer

    2012-01-01

    storage conditions. Methods. Petrolatum samples of methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (2-HEMA), 2-hydroxypropyl acrylate (2-HPA), cinnamal and eugenol in patch test concentrations were stored in three different test chambers (IQ chamber™, IQ Ultimate™, and Van der Bend® transport...... during storage in the refrigerator. For these two chamber systems, the contact allergen concentration dropped below the stability limit in the following order: MMA, cinnamal, 2-HPA, eugenol, and 2-HEMA. In the Van der Bend® transport container, the contact allergens exhibited acceptable stability under...

  2. Graded Exercise Testing Protocols for the Determination of VO2max: Historical Perspectives, Progress, and Future Considerations

    Directory of Open Access Journals (Sweden)

    Nicholas M. Beltz

    2016-01-01

    Full Text Available Graded exercise testing (GXT is the most widely used assessment to examine the dynamic relationship between exercise and integrated physiological systems. The information from GXT can be applied across the spectrum of sport performance, occupational safety screening, research, and clinical diagnostics. The suitability of GXT to determine a valid maximal oxygen consumption (VO2max has been under investigation for decades. Although a set of recommended criteria exists to verify attainment of VO2max, the methods that originally established these criteria have been scrutinized. Many studies do not apply identical criteria or fail to consider individual variability in physiological responses. As an alternative to using traditional criteria, recent research efforts have been directed toward using a supramaximal verification protocol performed after a GXT to confirm attainment of VO2max. Furthermore, the emergence of self-paced protocols has provided a simple, yet reliable approach to designing and administering GXT. In order to develop a standardized GXT protocol, additional research should further examine the utility of self-paced protocols used in conjunction with verification protocols to elicit and confirm attainment of VO2max.

  3. Influence of stabilizer thickness on over-current test of YBCO-coated conductors

    Science.gov (United States)

    Kwon, N. Y.; Kim, H. S.; Kim, K. L.; Yim, S. W.; Kim, H.-R.; Hyun, O.-B.; Kim, H. M.; Lee, H. G.

    2009-04-01

    The increased use of distributed power generation has led to increasingly high fault current levels. A superconducting fault current limiter (SFCL) is a potential solution to prevent the problem of short-circuit currents. YBCO-coated conductors (CCs) are one of the most promising superconducting materials for SFCLs. Most YBCO CCs have stabilizers, which play a significant role in limiting the fault current in the SFCL. Therefore, the selection of the appropriate material and the thickness of the stabilizer of the CC used for the SFCL may affect its quench/recovery characteristics. In this paper, the quench/recovery characteristics of YBCO CC tapes having stabilizers with various thicknesses were investigated. The quench/recovery test results showed that, as the thickness of the stabilizer decreased, both the final approach temperature and the recovery time decreased.

  4. Pilates based core stability training in ambulant individuals with multiple sclerosis: protocol for a multi-centre randomised controlled trial

    OpenAIRE

    Freeman, Jennifer; Fox, Esther; Gear, Margaret; Hough, Alan

    2012-01-01

    Abstract Background People with Multiple Sclerosis (MS) frequently experience balance and mobility impairments, including reduced trunk stability. Pilates-based core stability training, which is aimed at improving control of the body's stabilising muscles, is popular as a form of exercise with people with MS and therapists. A replicated single case series study facilitated by the Therapists in MS Group in the United Kingdom (UK) provides preliminary evidence that this approach can improve bal...

  5. Development of Technique for Testing the Long-Term Stability of Silicon Microstrip Detectors

    International Nuclear Information System (INIS)

    Kosinov, A.V.; Maslov, N.I.; Naumov, S.V.; Ovchinnik, V.D.; Starodubtsev, A.F.; Vasiliev, G.P.; Yalovenko, V.I.; Bosisio, L.

    2006-01-01

    An automatic multi-channel set-up prototype for simultaneous testing of the Long-Term Stability (LTS) of more than ten detectors is described. The Inner Tracking System of the ALICE experiment will include about two thousand Double-sided Microstrip Detectors (DSMD). Efficient automatic measurement techniques are crucial for the LTS test, because the corresponding test procedure should be performed on each detector and requires long time, at least two days. By using special adapters for supporting and connecting the bare DSMDs, failing detectors can be screened out before module assembly, thus minimizing the cost. Automated probe stations developed for a special purpose or for microelectronics industry are used for measuring physical static DSMD characteristics and check good-to-bad elements ratio for DSMD. However, automated (or semi-automatic)test benches for studying LTS or testing DSMD long-term stability before developing a detecting module are absent

  6. Temperature Stability and Control Requirements for Thermal Vacuum/Thermal Balance Testing of the Aquarius Radiometer

    Science.gov (United States)

    Johnson, Chris

    2008-01-01

    The paper describes the specific temperature stability and control requirements for the thermal vacuum and thermal balance testing of the Aquarius Instrument at the Goddard Space Flight Center in Greenbelt, Maryland. The testing was conducted in the 10' wide x 15' deep Facility 225 Thermal Vacuum chamber. The temperature control stability requirements were less than .14 C RMS thermal variation over a seven-day period. The thermal test specification also called for the ability to impose a high-resolution sinusoidal variation for all heater zones. The special requirements of the Aquarius radiometer test necessitated the construction of a multi-function test fixture and the modification of two existing heater controller racks.

  7. Verification of a Proposed Clinical Electroacoustic Test Protocol for Personal Digital Modulation Receivers Coupled to Cochlear Implant Sound Processors.

    Science.gov (United States)

    Nair, Erika L; Sousa, Rhonda; Wannagot, Shannon

    Guidelines established by the AAA currently recommend behavioral testing when fitting frequency modulated (FM) systems to individuals with cochlear implants (CIs). A protocol for completing electroacoustic measures has not yet been validated for personal FM systems or digital modulation (DM) systems coupled to CI sound processors. In response, some professionals have used or altered the AAA electroacoustic verification steps for fitting FM systems to hearing aids when fitting FM systems to CI sound processors. More recently steps were outlined in a proposed protocol. The purpose of this research is to review and compare the electroacoustic test measures outlined in a 2013 article by Schafer and colleagues in the Journal of the American Academy of Audiology titled "A Proposed Electroacoustic Test Protocol for Personal FM Receivers Coupled to Cochlear Implant Sound Processors" to the AAA electroacoustic verification steps for fitting FM systems to hearing aids when fitting DM systems to CI users. Electroacoustic measures were conducted on 71 CI sound processors and Phonak Roger DM systems using a proposed protocol and an adapted AAA protocol. Phonak's recommended default receiver gain setting was used for each CI sound processor manufacturer and adjusted if necessary to achieve transparency. Electroacoustic measures were conducted on Cochlear and Advanced Bionics (AB) sound processors. In this study, 28 Cochlear Nucleus 5/CP810 sound processors, 26 Cochlear Nucleus 6/CP910 sound processors, and 17 AB Naida CI Q70 sound processors were coupled in various combinations to Phonak Roger DM dedicated receivers (25 Phonak Roger 14 receivers-Cochlear dedicated receiver-and 9 Phonak Roger 17 receivers-AB dedicated receiver) and 20 Phonak Roger Inspiro transmitters. Employing both the AAA and the Schafer et al protocols, electroacoustic measurements were conducted with the Audioscan Verifit in a clinical setting on 71 CI sound processors and Phonak Roger DM systems to

  8. Straightforward synthetic protocol for the introduction of stabilized C nucleophiles in the BODIPY core for advanced sensing and photonic applications.

    Science.gov (United States)

    Gutiérrez-Ramos, Brenda D; Bañuelos, Jorge; Arbeloa, Teresa; López Arbeloa, Iñigo; González-Navarro, Paulina E; Wrobel, Kazimierz; Cerdán, Luis; García-Moreno, Inmaculada; Costela, Angel; Peña-Cabrera, Eduardo

    2015-01-19

    A straightforward synthetic protocol to directly incorporate stabilized 1,3-dicarbonyl C nucleophiles to the meso position of BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) is reported. Soft nucleophiles generated by deprotonation of 1,3-dicarbonyl derivatives smoothly displace the 8-methylthio group from 8-(methylthio)BODIPY analogues in the presence of Cu(I) thiophenecarboxylate in stoichiometric amounts at room temperature. Seven highly fluorescent new derivatives are prepared with varying yields (20-92%) in short reaction times (5-30 min). The excellent photophysical properties of the new dyes allow focusing on applications never analyzed before for BODIPYs substituted with stabilized C nucleophiles such as pH sensors and lasers in liquid and solid state, highlighting the relevance of the synthetic protocol described in the present work. The attainment of these dyes, with strong UV absorption and highly efficient and stable laser emission in the green spectral region, concerns to one of the greatest challenges in the ongoing development of advanced photonic materials with relevant applications. In fact, organic dyes with emission in the green are the only ones that allow, by frequency-doubling processes, the generation of tunable ultraviolet (250-350 nm) radiation, with ultra-short pulses. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. [The effect of a warm-up protocol on the sit-and-reach test score in adolescent students].

    Science.gov (United States)

    Díaz-Soler, María Angeles; Vaquero-Cristóbal, Raquel; Espejo-Antúnez, Luis; López-Miñarro, Pedro Ángel

    2015-06-01

    Sit-and-reach tests are often used in physical education classes for measurement of hamstring extensibility in students, without a standar protocol to perform it. To analyze the effect of a warm-up protocol based on locomotion activities and stretching in the sit-and-reach scores in adolescent students. A total of 47 teenagers students (17 boys and 30 girls) performed the sit-and-reach test before, immediately after, and 5 and 10 minutes after completing a structured warm-up. The warm-up consisted on a part of continuous running, dynamic locomotor and mobility activities as well as static stretching of lower limbs (quadriceps, hamstrings, adductors, iliopsoas and gastrocnemius), with a total duration of 8 minutes. Between measurements after warm-up, the participants remained standing without performing any exercise and/or stretching. After warm-up there was a significant improvement in the sit-and-reach score (+ 2.15 cm) (p test). A warm-up protocol performed before the sit-and-reach test, comprised by locomotion, dynamic activities and stretching, improves significantly the distance achieved in this test. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  10. Technical protocol for laboratory tests of transformation of veterinary medicinal products and biocides in liquid manures. Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    Kreuzig, Robert [Technische Univ. Braunschweig (Germany). Inst. fuer Oekologische Chemie und Abfallanalytik

    2010-07-15

    The technical protocol under consideration describes a laboratory test method to evaluate the transformation of chemicals in liquid bovine and pig manures under anaerobic conditions and primarily is designed for veterinary medicinal products and biocides. The environmentally relevant entry routes into liquid manures occur via urine and feces of cattle and pigs in stable housings after excretion of veterinary medicinal products as parent compounds or metabolites and after the application of biocides in animal housings. Further entry routes such as solid dung application and direct dung pat deposition by production animals on pasture are not considered by this technical protocol. Thus, this technical protocol focused on the sampling of excrements from cattles and pigs kept in stables and fed under standard nutrition conditions. This approach additionally ensures that excrement samples are operationally free of any contamination by veterinary medicinal products and biocides. After the matrix characterization, reference-manure samples are prepared from the excrement samples by adding tap water to adjust defined dry substance contents typical for bovine or pig manures. This technical protocol comprehends a tiered experimental design in two parts: (a) Sampling of excrements and preparation of reference bovine and pig manures; (b) Testing of anaerobic transformation of chemicals in reference manures.

  11. A new free-surface stabilization algorithm for geodynamical modelling: Theory and numerical tests

    Science.gov (United States)

    Andrés-Martínez, Miguel; Morgan, Jason P.; Pérez-Gussinyé, Marta; Rüpke, Lars

    2015-09-01

    The surface of the solid Earth is effectively stress free in its subaerial portions, and hydrostatic beneath the oceans. Unfortunately, this type of boundary condition is difficult to treat computationally, and for computational convenience, numerical models have often used simpler approximations that do not involve a normal stress-loaded, shear-stress free top surface that is free to move. Viscous flow models with a computational free surface typically confront stability problems when the time step is bigger than the viscous relaxation time. The small time step required for stability (develop strategies that mitigate the stability problem by making larger (at least ∼10 Kyr) time steps stable and accurate. Here we present a new free-surface stabilization algorithm for finite element codes which solves the stability problem by adding to the Stokes formulation an intrinsic penalization term equivalent to a portion of the future load at the surface nodes. Our algorithm is straightforward to implement and can be used with both Eulerian or Lagrangian grids. It includes α and β parameters to respectively control both the vertical and the horizontal slope-dependent penalization terms, and uses Uzawa-like iterations to solve the resulting system at a cost comparable to a non-stress free surface formulation. Four tests were carried out in order to study the accuracy and the stability of the algorithm: (1) a decaying first-order sinusoidal topography test, (2) a decaying high-order sinusoidal topography test, (3) a Rayleigh-Taylor instability test, and (4) a steep-slope test. For these tests, we investigate which α and β parameters give the best results in terms of both accuracy and stability. We also compare the accuracy and the stability of our algorithm with a similar implicit approach recently developed by Kaus et al. (2010). We find that our algorithm is slightly more accurate and stable for steep slopes, and also conclude that, for longer time steps, the optimal

  12. A Robust PCR Protocol for HIV Drug Resistance Testing on Low-Level Viremia Samples

    Directory of Open Access Journals (Sweden)

    Shivani Gupta

    2017-01-01

    Full Text Available The prevalence of drug resistance (DR mutations in people with HIV-1 infection, particularly those with low-level viremia (LLV, supports the need to improve the sensitivity of amplification methods for HIV DR genotyping in order to optimize antiretroviral regimen and facilitate HIV-1 DR surveillance and relevant research. Here we report on a fully validated PCR-based protocol that achieves consistent amplification of the protease (PR and reverse transcriptase (RT regions of HIV-1 pol gene across many HIV-1 subtypes from LLV plasma samples. HIV-spiked plasma samples from the External Quality Assurance Program Oversight Laboratory (EQAPOL, covering various HIV-1 subtypes, as well as clinical specimens were used to optimize and validate the protocol. Our results demonstrate that this protocol has a broad HIV-1 subtype coverage and viral load span with high sensitivity and reproducibility. Moreover, the protocol is robust even when plasma sample volumes are limited, the HIV viral load is unknown, and/or the HIV subtype is undetermined. Thus, the protocol is applicable for the initial amplification of the HIV-1 PR and RT genes required for subsequent genotypic DR assays.

  13. Very high stability systems: LMJ target alignment system and MTG imager test setup

    Science.gov (United States)

    Compain, Eric; Maquet, Philippe; Kunc, Thierry; Marque, Julien; Lauer-Solelhac, Maxime; Delage, Laurent; Lanternier, Catherine

    2015-09-01

    Most of space instruments and research facilities require test equipment with demanding opto-mechanical stability. In some specific cases, when the stability performance directly drives the final performance of the scientific mission and when feasibility is questionable, specific methods must be implemented for the associated technical risk management. In present paper, we will present our heritage in terms of methodology, design, test and the associated results for two specific systems : the SOPAC-POS and the MOTA, generating new references for future developments. From a performance point of view, we will emphasis on following key parameters : design symmetry, thermal load management, and material and structural choices. From a method point of view the difficulties arise first during design, from the strong coupling between the thermal, mechanical and optical performance models, and then during testing, from the difficulty of conceiving test setup having appropriate performance level. We will present how these limitations have been overcome. SOPAC-POS is the target alignment system of the LMJ, Laser Mega Joule, the French inertial confinement fusion research center. Its stability has been demonstrated by tests in 2014 after 10 years of research and development activities, achieving 1μm stability @ 6m during one hour periods. MOTA is an Optical Ground Support Equipment aiming at qualifying by tests the Flexible Combined Imager (FCI). FCI is an instrument for the meteorological satellite MTG-I, a program of and funded by the European Space Agency and under prime contractorship of Thales Alenia Space. Optimized design will allow to get better than 0.2 μrad stability for one hour periods, as required for MTF measurement.

  14. Methods study of homogeneity and stability test from cerium oxide CRM candidate

    International Nuclear Information System (INIS)

    Samin; Susanna TS

    2016-01-01

    The methods study of homogeneity and stability test from cerium oxide CRM candidate has been studied based on ISO 13258 and KAN DP. 01. 34. The purpose of this study was to select the test method homogeneity and stability tough on making CRM cerium oxide. Prepared 10 sub samples of cerium oxide randomly selected types of analytes which represent two compounds, namely CeO 2 and La 2 O 3 . At 10 sub sample is analyzed CeO 2 and La 2 O 3 contents in duplicate with the same analytical methods, by the same analyst, and in the same laboratory. Data analysis results calculated statistically based on ISO 13528 and KAN DP.01.34. According to ISO 13528 Cerium Oxide samples said to be homogeneous if Ss ≤ 0.3 σ and is stable if | Xr – Yr | ≤ 0.3 σ. In this study, the data of homogeneity test obtained CeO 2 is Ss = 2.073 x 10-4 smaller than 0.3 σ (0.5476) and the stability test obtained | Xr - Yr | = 0.225 and the price is < 0.3 σ. Whereas for La 2 O 3 , the price for homogeneity test obtained Ss = 1.649 x 10-4 smaller than 0.3 σ (0.4865) and test the stability of the price obtained | Xr - Yr | = 0.2185 where the price is < 0.3 σ. Compared with the method from KAN, a sample of cerium oxide has also been homogenized for Fcalc < Ftable and stable, because | Xi - Xhm | < 0.3 x n IQR. Provided that the results of the evaluation homogeneity and stability test from CeO 2 CRM candidate test data were processed using statistical methods ISO 13528 is not significantly different with statistical methods from KAN DP.01.34, which together meet the requirements of a homogeneous and stable. So the test method homogeneity and stability test based on ISO 13528 can be used to make CRM cerium oxide. (author)

  15. The Higgs boson and Top quark masses as tests of Electroweak Vacuum Stability

    Energy Technology Data Exchange (ETDEWEB)

    Masina, Isabella

    2013-04-15

    The measurements of the Higgs boson and top quark masses can be used to extrapolate the Standard Model Higgs potential at energies up to the Planck scale. Adopting a Next-to-Next-to-Leading Order renormalization procedure, we argue that electroweak vacuum stability is at present allowed, discuss the associated theoretical and experimental errors and the prospects for its future tests.

  16. Evaluation of seismic testing for quality assurance of lime-stabilized soil.

    Science.gov (United States)

    2013-08-01

    This study sought to determine the technical feasibility of using seismic techniques to measure the : laboratory and field seismic modulus of lime-stabilized soils (LSS), and to compare/correlate test results : from bench-top (free-free resonance) se...

  17. Temporal Stability of Strength-Based Assessments: Test-Retest Reliability of Student and Teacher Reports

    Science.gov (United States)

    Romer, Natalie; Merrell, Kenneth W.

    2013-01-01

    This study focused on evaluating the temporal stability of self-reported and teacher-reported perceptions of students' social and emotional skills and assets. We used a test-retest reliability procedure over repeated administrations of the child, adolescent, and teacher versions of the "Social-Emotional Assets and Resilience Scales".…

  18. Comparison of genome stability in two pig breeds by using the sister chromatid exchange (SCE test

    Directory of Open Access Journals (Sweden)

    V. Barbieri

    2010-01-01

    Full Text Available The sister chromatid exchange (SCE test has been used to detect genome stability in humans (Chaganti, 1974 and the main livestock species (Ciotola et al., 2004; Di Meo et al., 2000; Di Berardino et al., 1979, and to discover DNA damage caused by a variety of natural and artificial chemical compounds (Iannuzzi et al., 1990.

  19. Eye-head stabilization mechanism for a humanoid robot tested on human inertial data

    DEFF Research Database (Denmark)

    Vannucci, Lorenzo; Falotico, Egidio; Tolu, Silvia

    2016-01-01

    they keep the image stationary on the retina. In this work we present the first complete model of eye-head stabilization based on the coordination of VCR and VOR. The model is provided with learning and adaptation capabilities based on internal models. Tests on a simulated humanoid platform replicating...

  20. Transitioning Adolescents and Young Adults With HIV Infection to Adult Care: Pilot Testing the "Movin' Out" Transitioning Protocol.

    Science.gov (United States)

    Maturo, Donna; Powell, Alexis; Major-Wilson, Hannah; Sanchez, Kenia; De Santis, Joseph P; Friedman, Lawrence B

    2015-01-01

    Advances in care and treatment of adolescents/young adults with HIV infection have made survival into adulthood possible, requiring transition to adult care. Researchers have documented that the transition process is challenging for adolescents/young adults. To ensure successful transition, a formal transition protocol is needed. Despite existing research, little quantitative evaluation of the transition process has been conducted. The purpose of the study was to pilot test the "Movin' Out" Transitioning Protocol, a formalized protocol developed to assist transition to adult care. A retrospective medical/nursing record review was conducted with 38 clients enrolled in the "Movin' Out" Transitioning Protocol at a university-based adolescent medicine clinic providing care to adolescents/young adults with HIV infection. Almost half of the participants were able to successfully transition to adult care. Reasons for failure to transition included relocation, attrition, lost to follow-up, and transfer to another adult service. Failure to transition to adult care was not related to adherence issues, X(2) (1, N=38)=2.49, p=.288; substance use, X(2) (1, N=38)=1.71, p=.474; mental health issues, X(2) (1, N=38)=2.23, p=.322; or pregnancy/childrearing, X(2) (1, N=38)=0.00, p=.627). Despite the small sample size, the "Movin' Out" Transitioning Protocol appears to be useful in guiding the transition process of adolescents/young adults with HIV infection to adult care. More research is needed with a larger sample to fully evaluate the "Movin' Out" Transitioning Protocol. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Postural stability in patients with decompression sickness evaluated by means of Quantitative Romberg testing

    DEFF Research Database (Denmark)

    Hedetoft, Morten; Hyldegaard, Ole

    2015-01-01

    OBJECTIVE: The present study was designed to retrospectively evaluate the use of quantitative Romberg's testing on postural stability during the course of hyperbaric oxygen (HBO2) therapy in patients presenting with decompression sickness (DCS). METHODS: The Quantitative Romberg test was used...... obtained with the Quantitative Romberg test were observed in the group of DCS with vertigo relative to DCS without vertigo and healthy controls. A stepwise improvement in postural instability for DCS patients with vertigo was found following HBO2 therapy. After three treatments of HBO2, postural stability...... was found to be within the normal range of healthy controls. CONCLUSIONS: The Quantitative Romberg test offers the the clinician a fast, reliable and objective set of parametrical data to document postural instability in patients with either confirmed or suspected DCS....

  2. Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Voils Corrine I

    2012-08-01

    Full Text Available Abstract Background We describe the study design, procedures, and development of the risk counseling protocol used in a randomized controlled trial to evaluate the impact of genetic testing for diabetes mellitus (DM on psychological, health behavior, and clinical outcomes. Methods/Design Eligible patients are aged 21 to 65 years with body mass index (BMI ≥27 kg/m2 and no prior diagnosis of DM. At baseline, conventional DM risk factors are assessed, and blood is drawn for possible genetic testing. Participants are randomized to receive conventional risk counseling for DM with eye disease counseling or with genetic test results. The counseling protocol was pilot tested to identify an acceptable graphical format for conveying risk estimates and match the length of the eye disease to genetic counseling. Risk estimates are presented with a vertical bar graph denoting risk level with colors and descriptors. After receiving either genetic counseling regarding risk for DM or control counseling on eye disease, brief lifestyle counseling for prevention of DM is provided to all participants. Discussion A standardized risk counseling protocol is being used in a randomized trial of 600 participants. Results of this trial will inform policy about whether risk counseling should include genetic counseling. Trial registration ClinicalTrials.gov Identifier NCT01060540

  3. 557 Test and Manage Protocol for 841 Patients Requiring Iodinated Contrast Media (Icm) in Pediatrics

    Science.gov (United States)

    Diaz, Maria Cristina; Lavrut, Alberto Jorge; Spinelli, Silvia Susana

    2012-01-01

    Background ICM's adverse effects are quite frequent and potentially serious. The use of protocols to test and manage patients receiving ICM could help to decrease the adverse effects because they advise against the studies or prescribe the administration of premedication; however, its use in pediatrics is still limited. We describe the results of the use of a test and management protocol for pediatric patients requiring ICM. Methods All the patients of a pediatric hospital prescribed with ICM between 31st January 2008 and 5th March 2011 were included. The following variables have been analyzed: age, sex, type of study to be performed, diagnoses and hospitalized or outpatient, risk (regular, increased or non-advised) and the presence of adverse reactions. We also analyzed the relation between risk and age, sex and condition (chi cuadrado o t test). Significance level P < 0.05. Results We included 841 patients (56.9% male, age = 92.7 ± 24.5 months, 60% hospitalized). The most frequent test was chest Tc (36%) and the most frequent diagnosis was solid tumors (25%). Patients with increased risk were significantly lower than those with regular risk (75.7 ± 69.7 months vs 109.7 ± 61.6, P < 0.001). During the research period there were no adverse effects. Conclusions The classification of risk groups by this Goverment Buenos Aires City protocols allows a rational management of the patients requiring ICM and minimize the adverse effects.

  4. International geomechanical commission. Underground nuclear testing in French Polynesia: stability and hydrology issues

    International Nuclear Information System (INIS)

    1999-01-01

    The International Geomechanical Commission is an independent group of experts in rock mechanics and hydrology. This commission has carried out a study on the rocks stability and hydrology of the atolls of Mururoa and Fangataufa (French Polynesia) after the stoppage of the French underground nuclear tests (147 tests all of all, from which 6 took place in 1995 and 1996). This book presents the results of this study. (J.S.)

  5. Stability of puppy reaction to traditional puppy aptitude test under experimentally reared condtions

    OpenAIRE

    Ishikawa, Keisuke; Eguchi, Yusuke; Uetake, Katsuji; Tnaka, Toshio

    2010-01-01

    The puppy aptitude test (PAT) is a general method for choosing a puppy. However, the reliability of the test has been in doubt because of its lack of a scientific base. In this report, we conducted PAT and some other behavioral tests before and after the establishment of socialization in order to investigate the stability of behavioral traits of puppies. Ten puppies were tested of eleven items on PAT at 57 and 140 days of age. The puppy’s behavior was videotaped and rated by four people using...

  6. Gold Nanoparticles: Synthesis, Stability Test, and Application for the Rice Growth

    OpenAIRE

    Wang, Aiwu; Ng, Hoi Pong; Xu, Yi; Li, Yuyu; Zheng, Yuhong; Yu, Jingping; Han, Fugui; Peng, Feng; Fu, Li

    2014-01-01

    In today’s science, with the use of nanotechnology, nanomaterials, which behave very differently from the bulk solid, can be made. One of the capable uses of nanomaterials is bioapplications which make good use of the specific properties of nanoparticles. However, since the nanoparticles will be used both in-vivo and in-vitro, their stability is an important issue to the scientists, concern. In this dissertation, we are going to test the stability of gold nanoparticles in a number of media in...

  7. Data Fusion Modeling for an RT3102 and Dewetron System Application in Hybrid Vehicle Stability Testing

    Directory of Open Access Journals (Sweden)

    Zhibin Miao

    2015-08-01

    Full Text Available More and more hybrid electric vehicles are driven since they offer such advantages as energy savings and better active safety performance. Hybrid vehicles have two or more power driving systems and frequently switch working condition, so controlling stability is very important. In this work, a two-stage Kalman algorithm method is used to fuse data in hybrid vehicle stability testing. First, the RT3102 navigation system and Dewetron system are introduced. Second, a modeling of data fusion is proposed based on the Kalman filter. Then, this modeling is simulated and tested on a sample vehicle, using Carsim and Simulink software to test the results. The results showed the merits of this modeling.

  8. Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments

    Science.gov (United States)

    Dia, Mahendra; Wehner, Todd C; Perkins-Veazie, Penelope; Hassell, Richard; Price, Daniel S; Boyhan, George E; Olson, Stephen M; King, Stephen R; Davis, Angela R; Tolla, Gregory E; Bernier, Jerome; Juarez, Benito

    2016-01-01

    Lycopene is a naturally occurring red carotenoid compound that is found in watermelon. Lycopene has antioxidant properties. Lycopene content, sugar content and hollowheart resistance are subject to significant genotype×environment interaction (G×E), which makes breeding for these fruit quality traits difficult. The objectives of this study were to (i) evaluate the influence of years and locations on lycopene content, sugar content and hollowheart resistance for a set of watermelon genotypes, and (ii) identify genotypes with high stability for lycopene, sugar, and hollowheart resistance. A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated, multi-harvest trials. Lycopene was tested in a subset of 10 genotypes. Data were analyzed using univariate and multivariate stability statistics (BLUP-GGE biplot) using SASGxE and RGxE programs. There were strong effects of environment as well as G×E interaction on watermelon quality traits. On the basis of stability measures, genotypes were classified as stable or unstable for each quality trait. 'Crimson Sweet' is an inbred line with high quality trait performance as well as trait stability. 'Stone Mountain', 'Tom Watson', 'Crimson Sweet' and 'Minilee' were among the best genotypes for lycopene content, sugar content and hollowheart resistance. We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits. The chart will assist in choosing parents for improvement of watermelon cultivars. See http://cuke.hort.ncsu.edu/cucurbit/wmelon/wmelonmain.html. PMID:28066557

  9. Effect of root canal rinsing protocol on dentin bond strength of two resin cements using three different method of test.

    Science.gov (United States)

    Khoroushi, Maryam; Sheikhi, Mohammadreza; Khalilian-Gourtani, Amirhossein; Soleimani, Bahram

    2016-07-01

    Different studies have used different tests to evaluate bond strength of resin cements to root dentin. In this in vitrostudy, three different tests were used to evaluate the bond strength of two resin cements to root dentin using two root dentin irrigation protocols. Ninety-six intact single-rooted teeth were selected for this study. Forty-eight teeth, with a root length of 15mm, were randomly divided into two groups and irrigated with normal saline or 2.5% sodium hypochlorite solutions during root canal preparation, respectively. For each 12 specimens from each group, fiber post #1 was bonded using an etch-and-rinse (Duo-Link) and a self-adhesive (BisCem) resin cement, respectively. After incubation, two specimens were prepared for the push-out test from the middle thirds of the roots. In another 24 teeth, after two 1.5-mm sections were prepared from the middle thirds of the prepared roots, sections of the post were bonded in two subgroups with each of the cements mentioned above and the samples were prepared for the pull-out test. For shear test, the crowns of 48 teeth were cut away, the dentin surfaces were prepared, the two irrigation solutions were used, and the resin cements were bonded. Data collected from the three tests were evaluated by ANOVA, post-hoc Tukey and Weibull tests (α=0.05). There were significant differences in the mean bond strength values between the three bond strength tests (Pstrength in all tests (P>0.05). Under the limitations of the present study, the method of the test used had an effect on the recorded bond strength between the resin cement and root dentin. Cement type and irrigation protocol resulted in similar variations with all the tests. Push-out and shear tests exhibited more coherent results. Bond strength, endodontically treated tooth, fiber post, resin cement, sodium hypochlorite.

  10. True Stability of Lubricants Determined Using the Ball-on-Disk Test

    Directory of Open Access Journals (Sweden)

    Angela Maria Tortora

    2016-01-01

    Full Text Available True stability of lubricants can be determined when there is minimum change in the contact area and also the intervention of wear debris in the contact zone. Here, we have used the ball-on-disk instrument with the migrating point contact, that is, relative motion between the ball and disk condition to fix the contact area and minimize the wear debris at the contact zone. The jump in the friction coefficient indicates the film failure, which appeared earlier for the motor oil 5W30 compared to 5W40. Such profile was not recorded in absence of relative motion. Therefore, 5W40 was considered to have a better lubricant stability than 5W30. Applying the same test condition to the natural lubricants shows that glycerol has better lubricant stability than glycerol-water mixture. Superior true lubricant stability by glycerol and 5W40 can be related to its high viscosity. However, they were less wear resistant compared to low viscosity lubricants like 5W30 and glycerol-water. We suspect the role of microscopic wear debris at the contact zone for this behavior although it should have been avoided in the migrating point contact condition. Overall, ball-on-disk instrument with a migrating point contact condition is an effective technique to determine the stability of lubricants.

  11. DEVELOPING THE STABILIZED MAPPING SYSTEM FOR THE GYROCOPTER – REPORT FROM THE FIRST TESTS

    Directory of Open Access Journals (Sweden)

    J. Kolecki

    2016-06-01

    Full Text Available The LiDAR mapping carried out using gyrocopters provides a relatively cheap alternative for traditional mapping involving airplanes. The costs of the fuel and the overall maintenance are much lower when compared to planes. At the same time the flight kinematics of the gyrocopter makes it an ideal vehicle for corridor mapping. However a limited payload and a strongly limited space prevent using stabilized platforms dedicated for aerial photogrammetry. As the proper stabilization of the laser scanner during the flight is crucial in order to keep the desirable quality of the LiDAR data, it was decided to develop the prototype of the stabilized, ultra-light mapping platform that can meet the restricted requirements of the gyrocopter. The paper starts with the brief discussion of the legal and practical aspects of the LiDAR data quality, dealing mostly with the influence of the flight imperfections on the point pattern and point density. Afterwards the mapping system prototype is characterized, taking into account three main components: stabilized platform, sensors and control. Subsequently first in-flight tests are described. Though the data are still not perfect mostly due to vibrations, the stabilization provides a substantial improvement of their geometry, reducing both roll and pitch deflections.

  12. Comparison between four and seven-day Ceriodaphnia dubia survival and reproduction test protocols using oil refinery effluent samples

    Directory of Open Access Journals (Sweden)

    Eduardo Cyrino Oliveira-Filho

    2008-02-01

    Full Text Available The aim of this study was to compare the 7-day Ceriodaphnia dubia survival and reproduction test with a 4 day test to evaluate the toxicity of oil refinery effluents. Both shown identical NOECs with three of 6 tested samples. With one of the tested samples, the 4-day NOEC was one tested-concentration lower, and with the remaining two samples, it was one tested-concentration higher than those obtained using the 7-day protocol. Then results suggested that 4 and 7-day protocols were comparable to detect toxic effects.O objetivo do presente estudo foi comparar os protocolos de sobrevivência e reprodução de Ceriodaphnia dubia com 7 e 4 dias de duração, avaliando a toxicidade de amostras de efluentes de refinaria de petróleo. Ambos os protocolos apresentaram NOECs idênticos para 3 das 6 amostras testadas. Com uma das amostras o NOEC no ensaio de 4 dias ficou numa concentração testada menor, e nas duas amostras restantes ele ficou numa concentração testada maior do que os NOECs obtidos no ensaio de 7 dias. Esses resultados sugerem que os protocolos de ensaio com 4 e 7 dias são comparáveis quanto a sensibilidade para detectar o efeito tóxico crônico de efluentes de refinaria de petróleo.

  13. Pilates based core stability training in ambulant individuals with multiple sclerosis: protocol for a multi-centre randomised controlled trial.

    Science.gov (United States)

    Freeman, Jennifer; Fox, Esther; Gear, Margaret; Hough, Alan

    2012-04-05

    People with Multiple Sclerosis (MS) frequently experience balance and mobility impairments, including reduced trunk stability. Pilates-based core stability training, which is aimed at improving control of the body's stabilising muscles, is popular as a form of exercise with people with MS and therapists. A replicated single case series study facilitated by the Therapists in MS Group in the United Kingdom (UK) provides preliminary evidence that this approach can improve balance and mobility in ambulant people with MS; further evidence is needed to substantiate these findings to ensure that limited time, energy, finances and resources are used to best effect.This study builds upon the pilot work undertaken in the case series study by implementing a powered randomised controlled study, with the aims of: 1 Establishing the effectiveness of core stability training; 2 Comparing core stability training with standardised physiotherapy exercise; 3 Exploring underlying mechanisms of change associated with this intervention This is a multi-centre, double blind, block randomised, controlled trial. Eligible participants will be recruited from 4 UK centres. Participants will be randomly allocated to one of three groups: Pilates based core stability training, standardised physiotherapy exercise or contract-relax relaxation sessions (placebo control). All will receive face to face training sessions over a 12 week period; together with a 15 minute daily home programme. All will be assessed by a blinded assessor before training, at the end of the 12 week programme and at 4 week follow-up. The primary outcome measure is the 10 metre timed walk. Secondary outcome measures are the MS walking Scale (MSWS-12), the Functional Reach (forwards and lateral), a 10 point Numerical Rating Scale to determine "Difficulty in carrying a drink when walking", and the Activities-specific Balance Confidence (ABC) Scale. In addition, ultrasound imaging of the abdominal muscles will be performed before

  14. Pilates based core stability training in ambulant individuals with multiple sclerosis: protocol for a multi-centre randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Freeman Jennifer

    2012-04-01

    Full Text Available Abstract Background People with Multiple Sclerosis (MS frequently experience balance and mobility impairments, including reduced trunk stability. Pilates-based core stability training, which is aimed at improving control of the body's stabilising muscles, is popular as a form of exercise with people with MS and therapists. A replicated single case series study facilitated by the Therapists in MS Group in the United Kingdom (UK provides preliminary evidence that this approach can improve balance and mobility in ambulant people with MS; further evidence is needed to substantiate these findings to ensure that limited time, energy, finances and resources are used to best effect. This study builds upon the pilot work undertaken in the case series study by implementing a powered randomised controlled study, with the aims of: 1 Establishing the effectiveness of core stability training 2 Comparing core stability training with standardised physiotherapy exercise 3 Exploring underlying mechanisms of change associated with this intervention Methods This is a multi-centre, double blind, block randomised, controlled trial. Eligible participants will be recruited from 4 UK centres. Participants will be randomly allocated to one of three groups: Pilates based core stability training, standardised physiotherapy exercise or contract-relax relaxation sessions (placebo control. All will receive face to face training sessions over a 12 week period; together with a 15 minute daily home programme. All will be assessed by a blinded assessor before training, at the end of the 12 week programme and at 4 week follow-up. The primary outcome measure is the 10 metre timed walk. Secondary outcome measures are the MS walking Scale (MSWS-12, the Functional Reach (forwards and lateral, a 10 point Numerical Rating Scale to determine "Difficulty in carrying a drink when walking", and the Activities-specific Balance Confidence (ABC Scale. In addition, ultrasound imaging of the

  15. Formulation development and stability testing of oral morphine solution utilizing preformulation approach.

    Science.gov (United States)

    Preechagoon, Detpon; Sumyai, Viroj; Tontisirin, Khanittha; Aumpon, Sirikul; Pongjanyakul, Thaned

    2005-08-18

    Prefomulation approach utilizing the fractional-ordered randomized blocked design was employed for the formulation development and stability testing of morphine solution. Factors expecting to affect the stability of morphine were evaluated, i.e., vehicle, antioxidant, chelating agent, and pH of the solution. Eight formulations of a possible 16 were prepared according to the block design. The stability of the preparations was tested after 35 days of storage. The data of preformulation study were used for formulation development. The presence of glycerin and ethylenediamine-tetraacetic acid in the formulation, and the pH of the solution adjusted to 4, stabilized morphine. The concentration of morphine decreased drastically in the formulations containing sodium metabisulfite, and those pH adjusted to 6. After 35 days, only 65% of morphine was found in the formulation containing sodium metabisulfite and pH adjusted to 6. The results of preformulation study were used for preparing oral morphine preparations. Samples were kept in amber glass bottles and stored at 4 degrees C and 25 degrees C/75% RH for 13 months. No precipitation of the four formulations was detected. Only a decrease of odor and a small increase of pH value of the preparations (preformulation approach. They were stable more than 13 months when stored at 4 degrees C and 25 degrees C/75% RH.

  16. Multiple sample setup for testing the hydrothermal stability of adsorbents in thermal energy storage applications

    International Nuclear Information System (INIS)

    Fischer, Fabian; Laevemann, Eberhard

    2015-01-01

    Thermal energy storage based on adsorption and desorption of water on an adsorbent can achieve high energy storage densities. Many adsorbents lose adsorption capacity when operated under unfavourable hydrothermal conditions during adsorption and desorption. The stability of an adsorbent against stressing hydrothermal conditions is a key issue for its usability in adsorption thermal energy storage. We built an experimental setup that simultaneously controls the hydrothermal conditions of 16 samples arranged in a matrix of four temperatures and four water vapour pressures. This setup allows the testing of potential adsorbents between temperatures of 50 °C and 350 °C and water vapour pressures of up to 32 kPa. A measurement procedure that allows the detection of the hydrothermal stability of an adsorbent after defined time spans has been designed. We verified the functionality of the multiple sample measurements with a microporous adsorbent, a zeolite NaMSX. The hydrothermal stability of this zeolite is tested by water uptake measurements. A standard deviation lower than 1% of the 16 samples for detecting the hydrothermal stability enables setting different conditions in each sample cell. Further, we compared the water uptake measurements by measuring their adsorption isotherms with the volumetric device BELSORP Aqua 3 from Bel Japan. (paper)

  17. Using Transmission Control Protocol in the Trans-Pacific High Definition Video Satellite Communication Experiment - the Next Test

    Science.gov (United States)

    Hsu, E.

    1998-01-01

    Ths paper describes a future Transmission Control Protocol (TCP) test which was planned as a part of the Trans-Pacific High Definition Video Satellite Communications Experiment. The TCP test portion of the Trans-Pacific High Definition Video Satellite Communications Experiment intends to examine the correlation between the underlying assumptions of come TCP algorithms and the performance shortfalls observed when the algorithms are used in a stellite-based environment, and to make experimental changes to existing TCP variants to study the effects of the modifications.

  18. Development of a Protocol to Test Proprioceptive Utilization as a Predictor for Sensorimotor Adaptability

    Science.gov (United States)

    Goel, R.; De Dios, Y. E.; Gadd, N. E.; Caldwell, E. E.; Peters, B. T.; Bloomberg, J. J.; Oddsson, L. I. E.; Mulavara, A. P.

    2016-01-01

    Astronauts returning from space flight show significant inter-subject variations in their abilities to readapt to a gravitational environment because of their innate sensory weighting. The ability to predict the manner and degree to which each individual astronaut will be affected would improve the effectiveness of countermeasure training programs designed to enhance sensorimotor adaptability. We hypothesize participant's ability to utilize individual sensory information (vision, proprioception and vestibular) influences adaptation in sensorimotor performance after space flight. The goal of this study is to develop a reliable protocol to test proprioceptive utilization in a functional postural control task. Subjects "stand" in a supine position while strapped to a backpack frame holding a friction-free device using air-bearings that allow the subject to move freely in the frontal plane, similar to when in upright standing. The frame is attached to a pneumatic cylinder, which can provide different levels of a gravity-like force that the subject must balance against to remain "upright". The supine posture with eyes closed ensures reduced vestibular and visual contribution to postural control suggesting somatosensory and/or non-otolith vestibular inputs will provide relevant information for maintaining balance control in this task. This setup is called the gravity bed. Fourteen healthy subjects carried out three trials each with eyes open alternated with eyes closed, "standing" on their dominant leg in the gravity bed environment while loaded with 60 percent of their body weight. Subjects were instructed to: "use your sense of sway about the ankle and pressure changes under the foot to maintain balance." Maximum length of a trial was 45 seconds. A force plate underneath the foot recorded forces and moments during the trial and an inertial measurement unit (IMU) attached on the backpack's frame near the center of mass of the subject recorded upper body postural

  19. Prospective evaluation of a new protocol for the provisional use of perfusion imaging with exercise stress testing

    International Nuclear Information System (INIS)

    Duvall, W.L.; Savino, John A.; Levine, Elliot J.; Croft, Lori B.; Henzlova, Milena J.; Hermann, Luke K.

    2015-01-01

    Previous literature suggests that myocardial perfusion imaging (MPI) adds little to the prognosis of patients who exercise >10 metabolic equivalents (METs) during stress testing. With this in mind, we prospectively tested a provisional injection protocol in emergency department (ED) patients presenting for the evaluation of chest pain in which a patient would not receive an injection of radioisotope if adequate exercise was achieved without symptoms and a negative ECG response. All patients who presented to the ED over a 5-year period who were referred for stress testing as part of their ED evaluation were included. Patients considered for a provisional protocol were: exercise stress, age <65 years, no known coronary artery disease, and an interpretable rest ECG. Criteria for not injecting included a maximal predicted heart rate ≥85 %, ≥10 METs of exercise, no anginal symptoms during stress, and no ECG changes. Groups were compared based on stress test results, all-cause and cardiac mortality, follow-up cardiac testing, subsequent revascularization, and cost. A total of 965 patients were eligible with 192 undergoing exercise-only and 773 having perfusion imaging. After 41.6 ± 19.6 months of follow-up, all-cause mortality was similar in the exercise-only versus the exercise plus imaging group (2.6 % vs. 2.1 %, p = 0.59). There were no cardiac deaths in the exercise-only group. At 1 year there was no difference in the number of repeat functional stress tests (1.6 % vs. 2.1 %, p = 0.43), fewer angiograms (0 % vs. 4.0 %, p = 0.002), and a significantly lower cost (65 ± 332 vs 506 ± 1,991, p = 0.002; values are in US dollars) in the exercise-only group. The radiation exposure in the exercise plus imaging group was 8.4 ± 2.1 mSv. A provisional injection protocol has a very low mortality, few follow-up diagnostic tests, and lower cost compared to standard imaging protocols. If adopted it would decrease radiation exposure, save time and decrease health-care costs

  20. Prospective evaluation of a new protocol for the provisional use of perfusion imaging with exercise stress testing

    Energy Technology Data Exchange (ETDEWEB)

    Duvall, W.L. [Hartford Hospital, Division of Cardiology (Henry Low Heart Center), Hartford, CT (United States); Mount Sinai Medical Center, Division of Cardiology (Mount Sinai Heart), New York, NY (United States); Savino, John A.; Levine, Elliot J.; Croft, Lori B.; Henzlova, Milena J. [Mount Sinai Medical Center, Division of Cardiology (Mount Sinai Heart), New York, NY (United States); Hermann, Luke K. [Mount Sinai Medical Center, Department of Emergency Medicine, New York, NY (United States)

    2014-11-04

    Previous literature suggests that myocardial perfusion imaging (MPI) adds little to the prognosis of patients who exercise >10 metabolic equivalents (METs) during stress testing. With this in mind, we prospectively tested a provisional injection protocol in emergency department (ED) patients presenting for the evaluation of chest pain in which a patient would not receive an injection of radioisotope if adequate exercise was achieved without symptoms and a negative ECG response. All patients who presented to the ED over a 5-year period who were referred for stress testing as part of their ED evaluation were included. Patients considered for a provisional protocol were: exercise stress, age <65 years, no known coronary artery disease, and an interpretable rest ECG. Criteria for not injecting included a maximal predicted heart rate ≥85 %, ≥10 METs of exercise, no anginal symptoms during stress, and no ECG changes. Groups were compared based on stress test results, all-cause and cardiac mortality, follow-up cardiac testing, subsequent revascularization, and cost. A total of 965 patients were eligible with 192 undergoing exercise-only and 773 having perfusion imaging. After 41.6 ± 19.6 months of follow-up, all-cause mortality was similar in the exercise-only versus the exercise plus imaging group (2.6 % vs. 2.1 %, p = 0.59). There were no cardiac deaths in the exercise-only group. At 1 year there was no difference in the number of repeat functional stress tests (1.6 % vs. 2.1 %, p = 0.43), fewer angiograms (0 % vs. 4.0 %, p = 0.002), and a significantly lower cost (65 ± 332 vs 506 ± 1,991, p = 0.002; values are in US dollars) in the exercise-only group. The radiation exposure in the exercise plus imaging group was 8.4 ± 2.1 mSv. A provisional injection protocol has a very low mortality, few follow-up diagnostic tests, and lower cost compared to standard imaging protocols. If adopted it would decrease radiation exposure, save time and decrease health-care costs

  1. Development of a Ground Test and Analysis Protocol for NASA's NextSTEP Phase 2 Habitation Concepts

    Science.gov (United States)

    Gernhardt, Michael L.; Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Abercromby, Andrew F. J.

    2018-01-01

    The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low-Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts (SMEs) have been tasked with developing the ground-test protocol that will serve as the primary means by which these Phase 2 prototypes will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the Phase 2 Habitation Concepts is to consistently evaluate different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3. This paper describes the process by which the ground test protocol was developed and the objectives, methods, and metrics by which the NextSTEP Phase 2 Habitation Concepts will be rigorously and systematically evaluated. The protocol has been developed using both a top-down and bottom-up approach. Top-down development began with the Human Exploration and Operations Mission Directorate (HEOMD) exploration objectives and ISS Exploration Capability Study Team (IECST) candidate flight objectives. Strategic

  2. Stability Testing of a Wide Bone-Anchored Device after Surgery without Skin Thinning

    Directory of Open Access Journals (Sweden)

    Malou Hultcrantz

    2015-01-01

    Full Text Available Objective. To longitudinally follow the osseointegration using Resonance Frequency Analysis (RFA for different lengths of abutment on a new wide bone-anchored implant, introduced with the non-skin thinning surgical technique. Study Design. A single-center, prospective 1 year study following adults with bone-anchored hearing implants. Materials and Methods. Implantation was performed and followed for a minimum of 1 year. All patients were operated on according to the tissue preserving technique. A 4.5 mm wide fixture (Oticon Medical with varying abutments (9 to 12 mm was used and RFA was tested 1 week, 7 weeks, 6 months, and 12 months later. Implant Stability Quotient (ISQ, was measured from 1 to 100. Stability was compared to a group of patients (N=7 implanted with another brand (Cochlear BI400 of 4.5 mm fixtures. Results. All 10 adults concluded the study. None of the participants lost their implant during the test period indicating a good anchoring of abutments to the wide fixture tested. Stability testing was shown to vary depending on abutment length and time after surgery and with higher values for shorter abutments and increasing values over the first period of time. One patient changed the abutment from 12 to 9 mm and another from a 9 to a 12 during the year. No severe skin problems, numbness around the implant, or cosmetic problems arose. Conclusion. After 1 year of follow-up, combination of a wide fixture implant and the non-skin thinning surgical technique indicates a safe procedure with good stability and no abutment losses.

  3. Environmental effects on vertebrate species richness: testing the energy, environmental stability and habitat heterogeneity hypotheses.

    Directory of Open Access Journals (Sweden)

    Zhenhua Luo

    Full Text Available BACKGROUND: Explaining species richness patterns is a central issue in biogeography and macroecology. Several hypotheses have been proposed to explain the mechanisms driving biodiversity patterns, but the causes of species richness gradients remain unclear. In this study, we aimed to explain the impacts of energy, environmental stability, and habitat heterogeneity factors on variation of vertebrate species richness (VSR, based on the VSR pattern in China, so as to test the energy hypothesis, the environmental stability hypothesis, and the habitat heterogeneity hypothesis. METHODOLOGY/PRINCIPAL FINDINGS: A dataset was compiled containing the distributions of 2,665 vertebrate species and eleven ecogeographic predictive variables in China. We grouped these variables into categories of energy, environmental stability, and habitat heterogeneity and transformed the data into 100 × 100 km quadrat systems. To test the three hypotheses, AIC-based model selection was carried out between VSR and the variables in each group and correlation analyses were conducted. There was a decreasing VSR gradient from the southeast to the northwest of China. Our results showed that energy explained 67.6% of the VSR variation, with the annual mean temperature as the main factor, which was followed by annual precipitation and NDVI. Environmental stability factors explained 69.1% of the VSR variation and both temperature annual range and precipitation seasonality had important contributions. By contrast, habitat heterogeneity variables explained only 26.3% of the VSR variation. Significantly positive correlations were detected among VSR, annual mean temperature, annual precipitation, and NDVI, whereas the relationship of VSR and temperature annual range was strongly negative. In addition, other variables showed moderate or ambiguous relations to VSR. CONCLUSIONS/SIGNIFICANCE: The energy hypothesis and the environmental stability hypothesis were supported, whereas little

  4. Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy

    Directory of Open Access Journals (Sweden)

    Kaps Christian

    2009-07-01

    Full Text Available Abstract Background Surgery for disc herniations can be complicated by two major problems: painful degeneration of the spinal segment and re-herniation. Therefore, we examined an absorbable poly-glycolic acid (PGA biomaterial, which was lyophilized with hyaluronic acid (HA, for its utility to (a re-establish spinal stability and to (b seal annulus fibrosus defects. The biomechanical properties range of motion (ROM, neutral zone (NZ and a potential annulus sealing capacity were investigated. Methods Seven bovine, lumbar spinal units were tested in vitro for ROM and NZ in three consecutive stages: (a intact, (b following nucleotomy and (c after insertion of a PGA/HA nucleus-implant. For biomechanical testing, spinal units were mounted on a loading-simulator for spines. In three cycles, axial loading was applied in an excentric mode with 0.5 Nm steps until an applied moment of ± 7.5 Nm was achieved in flexion/extension. ROM and NZ were assessed. These tests were performed without and with annulus sealing by sewing a PGA/HA annulus-implant into the annulus defect. Results Spinal stability was significantly impaired after nucleotomy (p Conclusion PGA/HA biomaterial seems to be well suited for cell-free and cell-based regenerative treatment strategies in spinal surgery. Its abilities to restore spinal stability and potentially close annulus defects open up new vistas for regenerative approaches to treat intervertebral disc degeneration and for preventing implant herniation.

  5. Kinetic Modeling of Accelerated Stability Testing Enabled by Second Harmonic Generation Microscopy.

    Science.gov (United States)

    Song, Zhengtian; Sarkar, Sreya; Vogt, Andrew D; Danzer, Gerald D; Smith, Casey J; Gualtieri, Ellen J; Simpson, Garth J

    2018-04-03

    The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs). ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation. Here a study of accelerated stability testing on ritonavir, a human immunodeficiency virus (HIV) protease inhibitor, has been conducted. Under the condition for accelerated stability testing at 50 °C/75%RH and 40 °C/75%RH, ritonavir crystallization kinetics from amorphous solid dispersions were monitored by SHG microscopy. SHG microscopy coupled by image analysis yielded limits of detection for ritonavir crystals as low as 10 ppm, which is about 2 orders of magnitude lower than other methods currently available for crystallinity detection in ASDs. The four decade dynamic range of SHG microscopy enabled quantitative modeling with an established (JMAK) kinetic model. From the SHG images, nucleation and crystal growth rates were independently determined.

  6. An implementation and test platform for wide area stability assessment methods

    DEFF Research Database (Denmark)

    Wittrock, Martin Lindholm; Jóhannsson, Hjörtur

    2013-01-01

    This paper presents a software platform developed in MatLab with the purpose of supporting research, Development and testing of wide area algorithms for stability assessment and control. The development and testing process of algorithms exploiting real time wide area data from Phasor Measurement...... Units (PMU) can be very time consuming, especially if the testing procedure is not carried out in a systematic and automatic manner. The test platform overcomes this problem by automatically importing system model parameters, topology and simulation output from a time domain simulation of an instability...... scenario and automatically generating synthetic PMU snapshots of the system conditions. To demonstrate the platform’s potential for supporting research and development of wide area algorithms, a method to detect voltage instability is implemented and tested, giving results consistent with results from...

  7. Flight Test Experiment Design for Characterizing Stability and Control of Hypersonic Vehicles

    Science.gov (United States)

    Morelli, Eugene A.

    2008-01-01

    A maneuver design method that is particularly well-suited for determining the stability and control characteristics of hypersonic vehicles is described in detail. Analytical properties of the maneuver design are explained. The importance of these analytical properties for maximizing information content in flight data is discussed, along with practical implementation issues. Results from flight tests of the X-43A hypersonic research vehicle (also called Hyper-X) are used to demonstrate the excellent modeling results obtained using this maneuver design approach. A detailed design procedure for generating the maneuvers is given to allow application to other flight test programs.

  8. Recrystallization of niobium stabilized ferritic stainless steel during hot rolling simulation by torsion tests

    Directory of Open Access Journals (Sweden)

    Flávia Vieira Braga

    2016-01-01

    Full Text Available The aim of this study was to investigate the effect of finishing hot rolling temperature in promoting interpass recrystallization on a Nb-stabilized AISI 430 ferritic stainless steel. Torsion tests were performed in order to simulate the Steckel mill rolling process by varying the temperature ranges of the finishing passes. Interrupted torsion test were also performed and interpass recrystallization was evaluated via optical microscopy and electron backscatter diffraction (EBSD. As a result of this work, it has been established, within the restrictions of a Steckel mill rolling schedule, which thermomechanical conditions mostly favor SRX.

  9. Effects of different loading protocols on the secondary stability and peri-implant bone density of the single implants in the posterior maxilla.

    Science.gov (United States)

    Akoğlan, Mücahide; Tatli, Ufuk; Kurtoğlu, Cem; Salimov, Fariz; Kürkçü, Mehmet

    2017-08-01

    Immediate or early loading of dental implants becomes a clinically feasible concept. The aim was to evaluate the effects of different loading protocols (immediate, early, and delayed) on secondary stability and peri-implant bone density of single implants in the posterior maxilla. Thirty-nine implants (Dentium, South-Korea) were placed in 39 patients. After placement, implant stability values (ISQ) and baseline peri-implant bone density values derived from cone-beam computed tomography were recorded. Thirteen implants were included randomly in each loading groups. The secondary ISQ values were recorded during follow-up visits. Peri-implant bone density values were measured 1 year after placement again. Data was statistically analyzed. Immediate-loaded group showed the lowest ISQ values, 1 month after placement. During the next follow-up visits, delayed-loaded group showed the lowest ISQ values while other groups showed comparable results. Early loading increased the peri-implant bone density greater than the other groups. The peri-implant bone of early-loaded implants was significantly denser than that of immediate- and delayed-loaded implants, 1 year after placement. Density increment can be judged as the radiological findings of loaded-bone, which may also reduce the need for histomorphometric analysis of human biopsy to evaluate the bone reaction around the implants. © 2017 Wiley Periodicals, Inc.

  10. The stability of clay using mount Sinabung ash with unconfined compression test (uct) value

    Science.gov (United States)

    Puji Hastuty, Ika; Roesyanto; Hutauruk, Ronny; Simanjuntak, Oberlyn

    2018-03-01

    The soil has a important role as a highway’s embankment material (sub grade). Soil conditions are very different in each location because the scientifically soil is a very complex and varied material and the located on the field is very loose or very soft, so it is not suitable for construction, then the soil should be stabilized. The additive material commonly used for soil stabilization includes cement, lime, fly ash, rice husk ash, and others. This experiment is using the addition of volcanic ash. The purpose of this study was to determine the Index Properties and Compressive Strength maximum value with Unconfined Compression Test due to the addition of volcanic ash as a stabilizing agent along with optimum levels of the addition. The result showed that the original soil sample has Water Content of 14.52%; the Specific Weight of 2.64%; Liquid limit of 48.64% and Plasticity Index of 29.82%. Then, the Compressive Strength value is 1.40 kg/cm2. According to USCS classification, the soil samples categorized as the (CL) type while based on AASHTO classification, the soil samples are including as the type of A-7-6. After the soil is stabilized with a variety of volcanic ash, can be concluded that the maximum value occurs at mixture variation of 11% Volcanic Ash with Unconfined Compressive Strength value of 2.32 kg/cm2.

  11. Evaluation of porcine reproductive and respiratory syndrome stabilization protocols in 23 French Farrow-to-finish farms located in a high-density swine area.

    Science.gov (United States)

    Berton, Pauline; Normand, Valérie; Martineau, Guy-Pierre; Bouchet, Franck; Lebret, Arnaud; Waret-Szkuta, Agnès

    2017-01-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) is responsible for reproductive disorders in sows and respiratory problems in pigs, and has a major economic impact. Controlling PRRSV is therefore a priority for the swine industry. Stabilization of a herd, defined as the production of PRRSV-negative pigs at weaning from seropositive sows, is a common method of control, and different protocols have been described in the literature to achieve this stabilization. The objective of this study was to evaluate wether the combination of mass vaccination of sows and their piglets with a Genotype I modified live virus (MLV) vaccine, with temporal closure to the introduction of replacement animals and unidirectional pig and human flow can result in the production of PRRSV-negative pigs at weaning. The study took place in French farrow-to-finish farms located in a high-density swine area where the disease concerns over 60% of farms and only closely related strains of genotype I have been reported. Twenty-three 100-to-700 sow farrow-to-finish farms were selected prospectively between 2005 and 2014, regardless of their biosecurity level. Those farms adopted a stabilization protocol characterized by the following standardized measures: vaccination of sows, gilts, and piglets with the Genotype I MLV vaccine PORCILIS®PRRS, temporary herd closure, and strict internal biosecurity measures. Monitoring of herd status was then performed using a combination of 3 diagnostic tools: Real-time polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and Open reading frame (ORF) 5 and ORF7 sequencing. The status of finishing units (either active or inactive, meaning PRRSV-positive or PRRSV-negative, respectively) was not considered in this study. At the end of the monitoring period, considering the results of all the analyses, clinical signs, and epidemiology, 19 farms were considered stable and 1 remained unstable. In 3 farms it was commonly agreed to extend

  12. Active SAmpling Protocol (ASAP) to Optimize Individual Neurocognitive Hypothesis Testing: A BCI-Inspired Dynamic Experimental Design.

    Science.gov (United States)

    Sanchez, Gaëtan; Lecaignard, Françoise; Otman, Anatole; Maby, Emmanuel; Mattout, Jérémie

    2016-01-01

    The relatively young field of Brain-Computer Interfaces has promoted the use of electrophysiology and neuroimaging in real-time. In the meantime, cognitive neuroscience studies, which make extensive use of functional exploration techniques, have evolved toward model-based experiments and fine hypothesis testing protocols. Although these two developments are mostly unrelated, we argue that, brought together, they may trigger an important shift in the way experimental paradigms are being designed, which should prove fruitful to both endeavors. This change simply consists in using real-time neuroimaging in order to optimize advanced neurocognitive hypothesis testing. We refer to this new approach as the instantiation of an Active SAmpling Protocol (ASAP). As opposed to classical (static) experimental protocols, ASAP implements online model comparison, enabling the optimization of design parameters (e.g., stimuli) during the course of data acquisition. This follows the well-known principle of sequential hypothesis testing. What is radically new, however, is our ability to perform online processing of the huge amount of complex data that brain imaging techniques provide. This is all the more relevant at a time when physiological and psychological processes are beginning to be approached using more realistic, generative models which may be difficult to tease apart empirically. Based upon Bayesian inference, ASAP proposes a generic and principled way to optimize experimental design adaptively. In this perspective paper, we summarize the main steps in ASAP. Using synthetic data we illustrate its superiority in selecting the right perceptual model compared to a classical design. Finally, we briefly discuss its future potential for basic and clinical neuroscience as well as some remaining challenges.

  13. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    International Nuclear Information System (INIS)

    1994-12-01

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ

  14. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-01

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ.

  15. Laboratory tests of the response stability of the ATLAS Tile Calorimeter photomultipliers

    Science.gov (United States)

    Kazanin, V. F.

    2017-09-01

    High performance stability of the ATLAS Tile Calorimeter is achieved with a procedure including a multi-step calibration. One step of the calibration is based on measurements of the response stability to laser excitation of the PMTs that are used to read out the calorimeter cells. A facility to study the performance of the PMT stability response has been operating in the PISA-INFN laboratories since 2015. Goals of the tests are to study the time evolution of the PMT response in order to reproduce and understand the origin of the response drifts observed with the Tile Calorimeter PMTs during LHC Run I and Run II. A new statistical approach was used to measure the drift of the absolute PMT gain. A new procedure which combines studies of the time evolution of the global PMT responses and of the individual PMT gains was adopted to derive the evolution of the cathode quantum efficiency. The experimental setup of the Pisa facility and the first results obtained by testing about 30 PMTs are presented.

  16. Comparison of Ovarian volume and Antral follicle count with Endocrine tests for prediction of responsiveness in ovulation induction protocols

    Science.gov (United States)

    Adibi, Atoosa; Mardanian, Farahnaz; Hajiahmadi, Somaye

    2012-01-01

    Background: The aim of this study was to determine if the basal antral follicle number and ovarian volume contributes to the prediction of responsiveness in ovulation induction protocol and comparison of it with hormonal tests. Materials and Methods: 52 irregularly-menstruating patients, aged 18-46 years, participated in this prospective study. All the patients underwent a transvaginal sonography to measure the basal ovarian volume and the basal antral follicles count (AFC). Clomiphene citrate challenge test was measured by summation of measurements of FSH on day 2 and 10. All the women received clomiphene citrate from day 2 to 6. Ovarian responsiveness was measured 1 week after termination of clomiphene citrate and was used as gold standard. Results: Multiple regression analysis revealed that AFC was the only significant factor for ovarian responsiveness prediction. The area under the curve for AFC to discriminate responder ovaries was 0.66 (95% confidence interval, 0.87-0.99). The cutoff value for predicting ovarian responsiveness was 15.5. Conclusion: AFC can contribute to the prediction of responsiveness in ovulation induction protocol better than ovarian volume and hormonal tests. PMID:23326801

  17. Comparison of Ovarian volume and Antral follicle count with Endocrine tests for prediction of responsiveness in ovulation induction protocols

    Directory of Open Access Journals (Sweden)

    Atoosa Adibi

    2012-01-01

    Full Text Available Background: The aim of this study was to determine if the basal antral follicle number and ovarian volume contributes to the prediction of responsiveness in ovulation induction protocol and comparison of it with hormonal tests. Materials and Methods: 52 irregularly-menstruating patients, aged 18-46 years, participated in this prospective study. All the patients underwent a transvaginal sonography to measure the basal ovarian volume and the basal antral follicles count (AFC. Clomiphene citrate challenge test was measured by summation of measurements of FSH on day 2 and 10. All the women received clomiphene citrate from day 2 to 6. Ovarian responsiveness was measured 1 week after termination of clomiphene citrate and was used as gold standard. Results: Multiple regression analysis revealed that AFC was the only significant factor for ovarian responsiveness prediction. The area under the curve for AFC to discriminate responder ovaries was 0.66 (95% confidence interval, 0.87-0.99. The cutoff value for predicting ovarian responsiveness was 15.5. Conclusion: AFC can contribute to the prediction of responsiveness in ovulation induction protocol better than ovarian volume and hormonal tests.

  18. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol

    International Nuclear Information System (INIS)

    Dunkel, V.C.; Zeiger, E.; Brusick, D.; McCoy, E.; McGregor, D.; Mortelmans, K.; Rosenkranz, H.S.; Simmon, V.F.

    1984-01-01

    The Salmonella/microsome test developed by Ames and his coworkers has been widely used in the evaluation of chemicals for genotoxic potential. Although the value of this assay is well recognized, there have been no comprehensive studies on the interlaboratory reproducibility of the method using a standardized protocol. A program was therefore initiated to compare the results obtained in four laboratories from testing a series of coded mutagens and nonmutagens using a standardized protocol. Additional objectives of this study were to compare male Fisher 344 rat, B6C3F1 mouse, and Syrian hamster liver S-9 preparations for the activation of chemicals; to compare Aroclor 1254-induced liver S-9 from all three species with the corresponding non-induced liver S-9's; and to compare the response of Escherichia coli WP-2 uvrA with the Salmonella typhimurium tester strains recommended by Ames. Since a primary use of in vitro microbial mutagenesis tests is the identification of potential carcinogens by their mutagenicity, the authors decided to compare the animal species and strains used by the National Cancer Institute/National Toxicology Program (NCI/NTP) for animal carcinogenicity studies

  19. Development of a new Emergency Medicine Spinal Immobilization Protocol for trauma patients and a test of applicability by German emergency care providers.

    Science.gov (United States)

    Kreinest, Michael; Gliwitzky, Bernhard; Schüler, Svenja; Grützner, Paul A; Münzberg, Matthias

    2016-05-14

    In order to match the challenges of quickly recognizing and treating any life-threatening injuries, the ABCDE principles were established for the assessment and treatment of trauma patients. The high priority of spine protection is emphasized by the fact that immobilization of the cervical spine is performed at the very first step in the ABCDE principles. Immobilization is typically performed to prevent or minimize secondary damage to the spinal cord if instability of the spinal column is suspected. Due to increasing reports about disadvantages of spinal immobilization, the indications for performing spinal immobilization must be refined. The aim of this study was (i) to develop a protocol that supports decision-making for spinal immobilization in adult trauma patients and (ii) to carry out the first applicability test by emergency medical personnel. A structured literature search considering the literature from 1980 to 2014 was performed. Based on this literature and on the current guidelines, a new protocol that supports on scene decision-making for spinal immobilization has been developed. Parameters found in the literature concerning mechanisms and factors increasing the likelihood of spinal injury have been included in the new protocol. In order to test the applicability of the new protocol two surveys were performed on German emergency care providers by means of a questionnaire focused on correct decision-making if applying the protocol. Based on the current literature and guidelines, the Emergency Medicine Spinal Immobilization Protocol (E.M.S. IMMO Protocol) for adult trauma patients was developed. Following a fist applicability test involving 21 participants, the first version of the E.M.S. IMMO Protocol has to be graphically re-organized. A second applicability test comprised 50 participants with the current version of the protocol confirmed good applicability. Questions regarding immobilization of trauma patients could be answered properly using the E

  20. Transient and stability tests at Peach Bottom Atomic Power Station Unit 2 at end of Cycle 2

    International Nuclear Information System (INIS)

    Carmichael, L.A.; Niemi, R.O.

    1978-06-01

    Turbine trip transient and low flow stability tests were performed at the Peach Bottom-2 BWR/4 nuclear power plant prior to shutdown for refueling at end of Cycle 2 in April 1977. The results of the turbine trip transient tests showed that the fundamental mode of the acoustical pressure oscillation generated in the main steam piping propagates with relatively little attenuation into the reactor core. The magnitude of the neutron flux transient taking place in the BWR core was found to be strongly affected by the initial rate of pressure rise caused by the pressure oscillation. The measured neutron flux transients showed a strong spatial variation along the axis of the reactor core. Very little radial variation in the neutron flux transient was observed. The low-flow stability tests demonstrated that the Peach Bottom-2 Cycle 2 core exhibited a high degree of stability at the limiting test condition above the rated power-flow control line. The measured reactor stability margins showed the expected sensitivity to core power changes at minimum reactor core flow. The tests showed that the small pressure perturbation stability testing offers a useful and practical method of measuring core stability margins. The actual core stability margin was determined from the measured closed-loop pressure to average neutron flux transfer function data based on maximum likelihood estimates of the parameters in a relatively simple transfer function model determined from nonlinear regression analysis. Both static and dynamic error estimates were taken into consideration in evaluating the test results

  1. Ballistic Resistance of Armored Passenger Vehicles: Test Protocols and Quality Methods

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey M. Lacy; Robert E. Polk

    2005-07-01

    This guide establishes a test methodology for determining the overall ballistic resistance of the passenger compartment of assembled nontactical armored passenger vehicles (APVs). Because ballistic testing of every piece of every component of an armored vehicle is impractical, if not impossible, this guide describes a testing scheme based on statistical sampling of exposed component surface areas. Results from the test of the sampled points are combined to form a test score that reflects the probability of ballistic penetration into the passenger compartment of the vehicle.

  2. A comparison of the spine posture among several sit-and-reach test protocols.

    Science.gov (United States)

    Miñarro, Pedro A López; Andújar, Pilar Sáinz de Baranda; García, Pedro L Rodríguez; Toro, Enrique Ortega

    2007-12-01

    The purpose of the study was to compare the thoracic and lumbar spine posture among different sit-and-reach tests. Fifty-eight men and 47 women were asked to perform three trials of sit-and-reach test (SR), toe-touch test (TT), back-saver sit-and-reach test (BS) right and left, unilateral seated sit-and-reach test (USR) right and left, and V sit-and-reach test (VSR). Thoracic and lumbar angles were assessed with an inclinometer when subjects reached forward maximally. Women had a lower thoracic angle than men on all tests (ptest presented the highest values in lumbar spine when compared to other tests (30.5 degrees in men and 32.0 degrees in women). Unilateral seated sit-and-reach test presented the lowest lumbar angle in men (24.2 degrees for right leg and 23.9 degrees for left leg) and women (23.9 degrees in both legs) and there were significant differences with respect to the other tests. Characteristics and administration procedures of tests, such us uni- or bilateral, sitting or standing, measuring with or without box, parallel or V position, and hip position influence thoracic and lumbar postures.

  3. Using ISOS consensus test protocols for development of quantitative life test models in ageing of organic solar cells

    DEFF Research Database (Denmark)

    Kettle, J.; Stoichkov, V.; Kumar, D.

    2017-01-01

    As Organic Photovoltaic (OPV) development matures, the demand grows for rapid characterisation of degradation and application of Quantitative Accelerated Life Tests (QALT) models to predict and improve reliability. To date, most accelerated testing on OPVs has been conducted using ISOS consensus ...

  4. The Next Generation of High-Speed Dynamic Stability Wind Tunnel Testing (Invited)

    Science.gov (United States)

    Tomek, Deborah M.; Sewall, William G.; Mason, Stan E.; Szchur, Bill W. A.

    2006-01-01

    Throughout industry, accurate measurement and modeling of dynamic derivative data at high-speed conditions has been an ongoing challenge. The expansion of flight envelopes and non-conventional vehicle design has greatly increased the demand for accurate prediction and modeling of vehicle dynamic behavior. With these issues in mind, NASA Langley Research Center (LaRC) embarked on the development and shakedown of a high-speed dynamic stability test technique that addresses the longstanding problem of accurately measuring dynamic derivatives outside the low-speed regime. The new test technique was built upon legacy technology, replacing an antiquated forced oscillation system, and greatly expanding the capabilities beyond classic forced oscillation testing at both low and high speeds. The modern system is capable of providing a snapshot of dynamic behavior over a periodic cycle for varying frequencies, not just a damping derivative term at a single frequency.

  5. Thromboelastometry versus standard coagulation tests versus restrictive protocol to guide blood transfusion prior to central venous catheterization in cirrhosis: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Rocha, Leonardo Lima; Pessoa, Camila Menezes Souza; Neto, Ary Serpa; do Prado, Rogerio Ruscitto; Silva, Eliezer; de Almeida, Marcio Dias; Correa, Thiago Domingos

    2017-02-27

    Liver failure patients have traditionally been empirically transfused prior to invasive procedures. Blood transfusion is associated with immunologic and nonimmunologic reactions, increased risk of adverse outcomes and high costs. Scientific evidence supporting empirical transfusion is lacking, and the best approach for blood transfusion prior to invasive procedures in cirrhotic patients has not been established so far. The aim of this study is to compare three transfusion strategies (routine coagulation test-guided - ordinary or restrictive, or thromboelastometry-guided) prior to central venous catheterization in critically ill patients with cirrhosis. Design and setting: a double-blinded, parallel-group, single-center, randomized controlled clinical trial in a tertiary private hospital in São Paulo, Brazil. adults (aged 18 years or older) admitted to the intensive care unit with cirrhosis and an indication for central venous line insertion. Patients will be randomly assigned to three groups for blood transfusion strategy prior to central venous catheterization: standard coagulation tests-based, thromboelastometry-based, or restrictive. The primary efficacy endpoint will be the proportion of patients transfused with any blood product prior to central venous catheterization. The primary safety endpoint will be the incidence of major bleeding. Secondary endpoints will be the proportion of transfusion of fresh frozen plasma, platelets and cryoprecipitate; infused volume of blood products; hemoglobin and hematocrit before and after the procedure; intensive care unit and hospital length of stay; 28-day and hospital mortality; incidence of minor bleeding; transfusion-related adverse reactions; and cost analysis. This study will evaluate three strategies to guide blood transfusion prior to central venous line placement in severely ill patients with cirrhosis. We hypothesized that thromboelastometry-based and/or restrictive protocols are safe and would significantly

  6. Impact of organizational factors on adherence to laboratory testing protocols in adult HIV care in Lusaka, Zambia

    Directory of Open Access Journals (Sweden)

    Deo Sarang

    2012-05-01

    Full Text Available Abstract Background Previous operational research studies have demonstrated the feasibility of large-scale public sector ART programs in resource-limited settings. However, organizational and structural determinants of quality of care have not been studied. Methods We estimate multivariate regression models using data from 13 urban HIV treatment facilities in Zambia to assess the impact of structural determinants on health workers’ adherence to national guidelines for conducting laboratory tests such as CD4, hemoglobin and liver function and WHO staging during initial and follow-up visits as part of Zambian HIV care and treatment program. Results CD4 tests were more routinely ordered during initial history and physical (IHP than follow-up (FUP visits (93.0 % vs. 85.5 %; p  Conclusion Physical space plays an important role in ensuring high quality care in resource-limited setting. In the context of protocolized care, new staff members are likely to be more diligent in following the protocol verbatim rather than relying on memory and experience thereby improving adherence. Future studies should use prospective data to confirm the findings reported here.

  7. Dynamic stability test results on an 0.024 scale B-1 air vehicle

    Science.gov (United States)

    Beeman, R. R.

    1972-01-01

    Dynamic longitudinal and lateral-directional stability characteristics of the B-1 air vehicle were investigated in three wind tunnels at the Langley Research Center. The main rotary derivatives were obtained for an angle of attack range of -3 degrees to +16 degrees for a Mach number range of 0.2 to 2.16. Damping in roll data could not be obtained at the supersonic Mach numbers. The Langley 7 x 10 foot high speed tunnel, the 8 foot transonic pressure tunnel, and the 4 foot Unitary Plan wind tunnel were the test sites. An 0.024 scale light-weight model was used on a forced oscillation type balance. Test Reynolds number varied from 474,000/ft to 1,550,000/ft. through the Mach number range tested. The results showed that the dynamic stability characteristics of the model in pitch and roll were generally satisfactory up to an angle attack of about +6 degrees. In the wing sweep range from 15 to 25 degrees the positive damping levels in roll deteriorated rapidly above +2 degrees angle of attack. This reduction in roll damping is believed to be due to the onset of separation over the wing as stall is approached.

  8. Surrounding rock mass stability monitoring of underground caverns in a geomechanical model test using FBG sensors

    Science.gov (United States)

    Li, Yong; Zhu, Weishen; Zheng, Wenhua; He, Jianping

    2009-07-01

    Fiber Bragg Gratings (FBG) sensor is widely accepted as a structural stability device for all kinds of geomaterials by either embedding into or bonding onto the structures. The physical model in geotechnical engineering, which can accurately simulate the construction processes and the effects on the stability of underground caverns on basis of satisfying the similarity principles, is an actual physical entity. Due to a large number of restrained factors, a series of experiments are difficult to be carried out, in particular for how to obtain physical parameters during the experiments. Using the geo-mechanical model test of underground caverns in Shuangjiangkou Hydropower Station as a research object, the FBG sensors were mainly focused on and adopted to figure out the problem how to achieve the small displacements in the large-scale model test. The final experimental results show that the FBG sensor has higher measuring accuracy than other conventional sensors like strain gages and mini-extensometers. The experimental results agree well with the numerical simulation results. In the process of building the model, it's successful to embed the FBG sensors in the physical model through making a reserved pore and adding some special glue. In conclusion, FBG sensors can effectively measure the small displacement of monitoring points in the whole process of the geomechanical model test. The experimental results reveal the deformation and failure characteristics of the surrounding rock mass and make some guidance for the in-situ engineering construction.

  9. Short-term stability test for thorium soil candidate a reference material

    International Nuclear Information System (INIS)

    Clain, Almir F.; Fonseca, Adelaide M.G.; Dantas, Vanessa V.D.B.; Braganca, Maura J.C.; Souza, Poliana S.

    2015-01-01

    This work describes a methodology to determine the soil short-term stability after the steps of production in laboratory. The short-term stability of the soil is an essential property to be determined in order to producing a reference material. The soil is a candidate of reference material for chemical analysis of thorium with metrological traceability to be used in environmental analysis, equipment calibration, validation methods, and quality control. A material is considered stable in a certain temperature if the property of interest does not change with time, considering the analytical random fluctuations. Due to this, the angular coefficient from the graphic of Th concentration versus elapsed time must be near to zero. The analytical determinations of thorium concentration were performed by Instrumental Neutron activation Analysis. The slopes and their uncertainties were obtained from the regression lines at temperatures of 20 deg C and 60 deg C, with control temperature of -20 deg C. From the obtained data a t-test was applied. In both temperatures the calculated t-value was lower than the critical value, so we can conclude with 95% confidence level that no significant changes happened during the period studied concerning thorium concentration in soil at temperatures of 20 deg C and 60 deg C, showing stability at these temperatures. (author)

  10. Genetic test feedback with weight control advice: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Meisel Susanne F

    2012-12-01

    Full Text Available Abstract Background Genetic testing for risk of weight gain is already available over the internet despite uncertain benefits and concerns about adverse emotional or behavioral effects. Few studies have assessed the effect of adding genetic test feedback to weight control advice, even though one of the proposed applications of genetic testing is to stimulate preventive action. This study will investigate the motivational effect of adding genetic test feedback to simple weight control advice in a situation where weight gain is relatively common. Methods/design First-year university students (n = 800 will be randomized to receive either 1 their personal genetic test result for a gene (FTO related to weight gain susceptibility in addition to a leaflet with simple weight control advice (‘Feedback + Advice’ group, FA, or 2 only the leaflet containing simple weight control advice (‘Advice Only’ group, AO. Motivation to avoid weight gain and active use of weight control strategies will be assessed one month after receipt of the leaflet with or without genetic test feedback. Weight and body fat will be measured at baseline and eight months follow-up. We will also assess short-term psychological reactions to the genetic test result. In addition, we will explore interactions between feedback condition and gene test status. Discussion We hope to provide a first indication of the clinical utility of weight-related genetic test feedback in the prevention context. Trial registration Current controlled trials ISRCTN91178663

  11. Thermal-hydraulic stability tests for newly designed BWR rod bundle (step-III fuel type B)

    International Nuclear Information System (INIS)

    Ito, Y.; Itami, A.; Tsuda, K.; Nakamura, K.; Ishikawa, M.; Toba, A.; Omoto, A.

    2004-01-01

    The Step-III Fuel Type B is a new fuel design for high burn-up operation in BWRs in Japan. The fuel design uses a 9x9 - 9 rod bundle to accommodate the high fuel duty of high burn-up operation and a square water-channel to provide enhanced neutron moderation. The objective of this study is to confirm the thermal-hydraulic stability performance of the new fuel design by tests which simulate the parallel channel configuration of the BWR core. The stability testing was performed at the NFI test loop. The test bundle geometry used for the stability test is a 3x3 heater rod bundle which has about 1/8 of the cross section area of the full size 9x9 - 9 rod bundle. Full size heater rods were used to simulate the fuel rods. For parallel channel simulation, a bypass channel with a 6x6 - 8 heater rod bundle was connected in parallel with the 3x3 rod bundle test channel. The stability test results showed typical flow oscillation features which have been described as density wave oscillations. The stationary limit cycle oscillation extended flow amplitudes to several tens of a percent of the nominal value, during which periodic dry-out and re-wetting were observed. The test results were used for verification of a stability analysis code, which demonstrated that the stability performance of the new fuel design has been conservatively predicted. (author)

  12. Closed Kinetic Chain Upper Extremity Stability test (CKCUES test): a reliability study in persons with and without shoulder impingement syndrome.

    Science.gov (United States)

    Tucci, Helga Tatiana; Martins, Jaqueline; Sposito, Guilherme de Carvalho; Camarini, Paula Maria Ferreira; de Oliveira, Anamaria Siriani

    2014-01-03

    The Close Kinetic Chain Upper Extremity Stability Test (CKCUES test) is a low cost shoulder functional test that could be considered as a complementary and objective clinical outcome for shoulder performance evaluation. However, its reliability was tested only in recreational athletes' males and there are no studies comparing scores between sedentary and active samples. The purpose was to examine inter and intrasession reliability of CKCUES Test for samples of sedentary male and female with (SIS), for samples of sedentary healthy male and female, and for male and female samples of healthy upper extremity sport specific recreational athletes. Other purpose was to compare scores within sedentary and within recreational athletes samples of same gender. A sample of 108 subjects with and without SIS was recruited. Subjects were tested twice, seven days apart. Each subject performed four test repetitions, with 45 seconds of rest between them. The last three repetitions were averaged and used to statistical analysis. Intraclass Correlation Coefficient ICC2,1 was used to assess intrasession reliability of number of touches score and ICC2,3 was used to assess intersession reliability of number of touches, normalized score, and power score. Test scores within groups of same gender also were compared. Measurement error was determined by calculating the Standard Error of the Measurement (SEM) and Minimum detectable change (MDC) for all scores. The CKCUES Test showed excellent intersession reliability for scores in all samples. Results also showed excellent intrasession reliability of number of touches for all samples. Scores were greater in active compared to sedentary, with exception of power score. All scores were greater in active compared to sedentary and SIS males and females. SEM ranged from 1.45 to 2.76 touches (based on a 95% CI) and MDC ranged from 2.05 to 3.91(based on a 95% CI) in subjects with and without SIS. At least three touches are needed to be considered a

  13. Measurement of volume change in cementitious materials at early ages - Review of testing protocols and interpretation of results

    DEFF Research Database (Denmark)

    Sant, Gaurav; Lura, Pietro; Weiss, Jason

    2006-01-01

    Early-age cracking in concrete bridge decks, pavements, and superstructure elements has served as the impetus for substantial research on early-age shrinkage in cementitious materials. Much of this research has indicated how mixture proportions, constituent materials, and construction operations...... can be altered to reduce the risk of cracking. Unfortunately, many unrestrained shrinkage-testing protocols do not provide a comprehensive picture of the early-age shrinkage exhibited by cementitious materials, especially those used in higher-strength concrete. In this paper, the authors review...... correlated with one another. This can provide the end user with reliable test procedures to compare different paste compositions and different admixtures and can provide inputs for models that quantify cracking potential....

  14. Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol.

    Science.gov (United States)

    Wang, Y T; Mohammed, S D; Farmer, A D; Wang, D; Zarate, N; Hobson, A R; Hellström, P M; Semler, J R; Kuo, B; Rao, S S; Hasler, W L; Camilleri, M; Scott, S M

    2015-09-01

    The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner. To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC. Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, gender, age and study country were examined. For GI transit times, testing protocol was associated with differences in gastric emptying time (GET; shorter with protocol 2 (motility capsule ingested immediately after meal) vs. protocol 1 (motility capsule immediately before): median difference: 52 min, P = 0.0063) and colonic transit time (CTT; longer with protocol 2: median 140 min, P = 0.0189), but had no overall effect on whole gut transit time. Females had longer GET (by median 17 min, P = 0.0307), and also longer CTT by (104 min, P = 0.0285) and whole gut transit time by (263 min, P = 0.0077). Increasing age was associated with shorter small bowel transit time (P = 0.002), and study country also influenced small bowel and CTTs. Whole gut and CTTs showed clustering of data at values separated by 24 h, suggesting that describing these measures as continuous variables is invalid. Testing protocol, gender and study country also significantly influenced pH values. Regional GI transit times and pH values, delineated using the wireless motility capsule (WMC), vary based on testing protocol, gender, age and country. Standardisation of testing is crucial for cross-referencing in clinical practice and future research. © 2015 John Wiley & Sons Ltd.

  15. 75 FR 4323 - Additional Quantitative Fit-testing Protocols for the Respiratory Protection Standard

    Science.gov (United States)

    2010-01-27

    ...: Contact Ms. Jennifer Ashley, Office of Communications, Room N-3647, OSHA, U.S. Department of Labor, 200... test report prepared by an independent government research laboratory (e.g., Lawrence Livermore...

  16. Operational Ground Testing Protocol to Optimize Astronaut Sleep Medication Efficacy and Individual Effects

    Data.gov (United States)

    National Aeronautics and Space Administration — As of July 3, 2014, data collection has been completed for 29 participants, with each participant completing testing across three nights at the Astronaut Quarantine...

  17. Typical pedestrian accident scenarios for the development of autonomous emergency braking test protocols.

    Science.gov (United States)

    Lenard, James; Badea-Romero, Alexandro; Danton, Russell

    2014-12-01

    An increasing proportion of new vehicles are being fitted with autonomous emergency braking systems. It is difficult for consumers to judge the effectiveness of these safety systems for individual models unless their performance is evaluated through track testing under controlled conditions. This paper aimed to contribute to the development of relevant test conditions by describing typical circumstances of pedestrian accidents. Cluster analysis was applied to two large British databases and both highlighted an urban scenario in daylight and fine weather where a small pedestrian walks across the road, especially from the near kerb, in clear view of a driver who is travelling straight ahead. For each dataset a main test configuration was defined to represent the conditions of the most common accident scenario along with test variations to reflect the characteristics of less common accident scenarios. Some of the variations pertaining to less common accident circumstances or to a minority of casualties in these scenarios were proposed as optional or supplementary test elements for an outstanding performance rating. Many considerations are incorporated into the final design and implementation of an actual testing regime, such as cost and the state of development of technology; only the representation of accident data lay within the scope of this paper. It would be desirable to ascertain the wider representativeness of the results by analysing accident data from other countries in a similar manner. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Stability Test For Sorghum Mutant Lines Derived From Induced Mutations with Gamma-Ray Irradiation

    Directory of Open Access Journals (Sweden)

    S. Human

    2011-12-01

    Full Text Available Sorghum breeding program had been conducted at the Center for the Application of Isotopes and Radiation Technology, BATAN. Plant genetic variability was increased through induced mutations using gamma-ray irradiation. Through selection process in successive generations, some promising mutant lines had been identified to have good agronomic characteristics with high grain yield. These breeding lines were tested in multi location trials and information of the genotypic stability was obtained to meet the requirements for officially varietal release by the Ministry of Agriculture. A total of 11 sorghum lines and varieties consisting of 8 mutant lines derived from induced mutations (B-100, B-95, B-92, B-83, B-76, B-75, B-69 and Zh-30 and 3 control varieties (Durra, UPCA-S1 and Mandau were included in the experiment. All materials were grown in 10 agro-ecologically different locations namely Gunungkidul, Bantul, Citayam, Garut, Lampung, Bogor, Anyer, Karawaci, Cianjur and Subang. In each location, the local adaptability test was conducted by randomized block design with 3 replications. Data of grain yield was used for evaluating genotypic stability using AMMI approach. Results revealed that sorghum mutation breeding had generated 3 mutant lines (B-100, B-76 and Zh-30 exhibiting grain yield significantly higher than the control varieties. These mutant lines were genetically stable in all locations so that they would be recommended for official release as new sorghum varieties to the Ministry of Agriculture

  19. Ultrasonic, Molecular and Mechanical Testing Diagnostics in Natural Fibre Reinforced, Polymer-Stabilized Earth Blocks

    Directory of Open Access Journals (Sweden)

    C. Galán-Marín

    2013-01-01

    Full Text Available The aim of this research study was to evaluate the influence of utilising natural polymers as a form of soil stabilization, in order to assess their potential for use in building applications. Mixtures were stabilized with a natural polymer (alginate and reinforced with wool fibres in order to improve the overall compressive and flexural strength of a series of composite materials. Ultrasonic pulse velocity (UPV and mechanical strength testing techniques were then used to measure the porous properties of the manufactured natural polymer-soil composites, which were formed into earth blocks. Mechanical tests were carried out for three different clays which showed that the polymer increased the mechanical resistance of the samples to varying degrees, depending on the plasticity index of each soil. Variation in soil grain size distributions and Atterberg limits were assessed and chemical compositions were studied and compared. X-ray diffraction (XRD, X-ray fluorescence spectroscopy (XRF, and energy dispersive X-ray fluorescence (EDXRF techniques were all used in conjunction with qualitative identification of the aggregates. Ultrasonic wave propagation was found to be a useful technique for assisting in the determination of soil shrinkage characteristics and fibre-soil adherence capacity and UPV results correlated well with the measured mechanical properties.

  20. Arsenic stability in arsenopyrite-rich cemented paste backfills: a leaching test-based assessment.

    Science.gov (United States)

    Coussy, Samuel; Benzaazoua, Mostafa; Blanc, Denise; Moszkowicz, Pierre; Bussière, Bruno

    2011-01-30

    Arsenic (As) is a toxicant in tailings from sulphur deposits. It represents an environmental risk because of its high solubility. Tailings can be mixed with water (typically 25%) and a low proportion of hydraulic binder (3-7%) to produce a cemented paste backfill (CPB), stored in underground mine openings. CPB is a tailings storage technique, but it could also provide environmental advantages by stabilization of polluting elements such as As. Tailings from Casa Berardi mine (QC, Canada) contain As (3800 ppm), mainly in arsenopyrite form. For this study, three different CPBs were synthesized in laboratory using Casa Berardi tailings and three different binders. These pastes were submitted to various leaching tests after 28 days of curing. The results indicate that As is released at higher concentration for a fly ash-based CPB than for slag- and Portland cement-based CPB. However, at lower pH, As is better stabilized in fly ash-based samples. These differences can be explained by a variation of solubility of As-compounds in each CPB. Several mechanisms of As release occur, as diffusion and/or dissolution/precipitation. The accelerated weathering test results show that sulphide reactivity is buffered by the neutralizing minerals contained in CPB, and influence the As release behaviour by decreasing the oxidation of As-bearing sulphides. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. Testing Single and Combinations of Amendments for Stabilization of Metals in Contrasting Extremely Contaminated Soils

    Directory of Open Access Journals (Sweden)

    Siebielec G.

    2013-04-01

    Full Text Available Metals can be stabilized by soil amendments that increase metals adsorption or alter their chemical forms. Such treatments may limit the risk related to the contamination through reduction of metal transfer to the food chain (reduction of metal uptake by plants and its availability to soil organisms and metals migration within the environment. There is a need for experiments comparing various soil amendments available at reasonable amounts under similar environmental conditions. The other question is whether all components of soil environment or soil functions are similarly protected after remediation treatment. We conducted a series of pot studies to test some traditional and novel amendments and their combinations. The treatments were tested for several highly Zn/Cd/Pb contaminated soils. Among traditional amendments composts were the most effective – they ensured plant growth, increased soil microbial activity, reduced Cd in earthworms, reduced Pb bioaccessibility and increased share of unavailable forms of Cd and Pb.

  2. Treatability Test Plan for 300 Area Uranium Stabilization through Polyphosphate Injection

    Energy Technology Data Exchange (ETDEWEB)

    Vermeul, Vincent R.; Williams, Mark D.; Fritz, Brad G.; Mackley, Rob D.; Mendoza, Donaldo P.; Newcomer, Darrell R.; Rockhold, Mark L.; Williams, Bruce A.; Wellman, Dawn M.

    2007-06-01

    The U.S. Department of Energy has initiated a study into possible options for stabilizing uranium at the 300 Area using polyphosphate injection. As part of this effort, PNNL will perform bench- and field-scale treatability testing designed to evaluate the efficacy of using polyphosphate injections to reduced uranium concentrations in the groundwater to meet drinking water standards (30 ug/L) in situ. This technology works by forming phosphate minerals (autunite and apatite) in the aquifer that directly sequester the existing aqueous uranium in autunite minerals and precipitates apatite minerals for sorption and long term treatment of uranium migrating into the treatment zone, thus reducing current and future aqueous uranium concentrations. Polyphosphate injection was selected for testing based on technology screening as part of the 300-FF-5 Phase III Feasibility Study for treatment of uranium in the 300-Area.

  3. Fisher matrix forecasts for astrophysical tests of the stability of the fine-structure constant

    Directory of Open Access Journals (Sweden)

    C.S. Alves

    2017-07-01

    Full Text Available We use Fisher Matrix analysis techniques to forecast the cosmological impact of astrophysical tests of the stability of the fine-structure constant to be carried out by the forthcoming ESPRESSO spectrograph at the VLT (due for commissioning in late 2017, as well by the planned high-resolution spectrograph (currently in Phase A for the European Extremely Large Telescope. Assuming a fiducial model without α variations, we show that ESPRESSO can improve current bounds on the Eötvös parameter—which quantifies Weak Equivalence Principle violations—by up to two orders of magnitude, leading to stronger bounds than those expected from the ongoing tests with the MICROSCOPE satellite, while constraints from the E-ELT should be competitive with those of the proposed STEP satellite. Should an α variation be detected, these measurements will further constrain cosmological parameters, being particularly sensitive to the dynamics of dark energy.

  4. Experimental test of theory for the stability of partially saturated vertical cut slopes

    Science.gov (United States)

    Morse, Michael M.; Lu, N.; Wayllace, Alexandra; Godt, Jonathan W.; Take, W.A.

    2014-01-01

    This paper extends Culmann's vertical-cut analysis to unsaturated soils. To test the extended theory, unsaturated sand was compacted to a uniform porosity and moisture content in a laboratory apparatus. A sliding door that extended the height of the free face of the slope was lowered until the vertical cut failed. Digital images of the slope cross section and upper surface were acquired concurrently. A recently developed particle image velocimetry (PIV) tool was used to quantify soil displacement. The PIV analysis showed strain localization at varying distances from the sliding door prior to failure. The areas of localized strain were coincident with the location of the slope crest after failure. Shear-strength and soil-water-characteristic parameters of the sand were independently tested for use in extended analyses of the vertical-cut stability and of the failure plane angle. Experimental failure heights were within 22.3% of the heights predicted using the extended theory.

  5. Are specific testing protocols required for organic onion varieties? Analysis of onion variety testing under conventional and organic growing conditions

    NARCIS (Netherlands)

    Lammerts Van Bueren, E.; Osman, A.M.; Tiemens-Hulscher, M.; Struik, P.C.; Burgers, S.L.G.E.; Broek, van den R.C.F.M.

    2012-01-01

    Organic growers need information on variety performance under their growing conditions. A 4-year onion variety research project was carried out to investigate whether setting up a variety testing system combining conventional and organic variety trials is feasible and efficient rather than

  6. How many trials are needed to achieve performance stability of the Timed Up & Go test in patients with hip fracture?

    DEFF Research Database (Denmark)

    Kristensen, Morten T; Ekdahl, Charlotte; Kehlet, Henrik

    2010-01-01

    To examine the number of trials needed to achieve performance stability of the Timed Up & Go (TUG) test using a standardized walking aid in patients with hip fracture who are allowed full weight bearing (FWB).......To examine the number of trials needed to achieve performance stability of the Timed Up & Go (TUG) test using a standardized walking aid in patients with hip fracture who are allowed full weight bearing (FWB)....

  7. Conformance testing strategies for DICOM protocols in a heterogenous communications system

    Science.gov (United States)

    Meyer, Ralph; Hewett, Andrew J.; Cordonnier, Emmanuel; Piqueras, Joachim; Jensch, Peter F.

    1995-05-01

    The goal of the DICOM standard is to define a standard network interface and data model for imaging devices from various vendors. It shall facilitate the development and integration of information systems and picture archiving and communication systems (PACS) in a networked environment. Current activities in Oldenburg, Germany include projects to establish cooperative work applications for radiological purposes, comprising (joined) text, data, signal and image communications, based on narrowband ISDN and ATM communication for regional and Pan European applications. In such a growing and constantly changing environment it is vital to have a solid and implementable plan to bring standards in operation. A communication standard alone cannot ensure interoperability between different vendor implementations. Even DICOM does not specify implementation-specific requirements nor does it specify a testing procedure to assess an implementation's conformance to the standard. The conformance statements defined in the DICOM standard only allow a user to determine which optional components are supported by the implementation. The goal of our work is to build a conformance test suite for DICOM. Conformance testing can aid to simplify and solve problems with multivendor systems. It will check a vendor's implementation against the DICOM standard and state the found subset of functionality. The test suite will be built in respect to the ISO 9646 Standard (OSI-Conformance Testing Methodology and Framework) which is a standard devoted to the subject of conformance testing implementations of Open Systems Interconnection (OSI) standards. For our heterogeneous communication environments we must also consider ISO 9000 - 9004 (quality management and quality assurance) to give the users the confidence in evolving applications.

  8. Deformation Monitoring of Geomechanical Model Test and Its Application in Overall Stability Analysis of a High Arch Dam

    Directory of Open Access Journals (Sweden)

    Baoquan Yang

    2015-01-01

    Full Text Available Geomechanical model testing is an important method for studying the overall stability of high arch dams. The main task of a geomechanical model test is deformation monitoring. Currently, many types of deformation instruments are used for deformation monitoring of dam models, which provide valuable information on the deformation characteristics of the prototype dams. However, further investigation is required for assessing the overall stability of high arch dams through analyzing deformation monitoring data. First, a relationship for assessing the stability of dams is established based on the comprehensive model test method. Second, a stability evaluation system is presented based on the deformation monitoring data, together with the relationships between the deformation and overloading coefficient. Finally, the comprehensive model test method is applied to study the overall stability of the Jinping-I high arch dam. A three-dimensional destructive test of the geomechanical model dam is conducted under reinforced foundation conditions. The deformation characteristics and failure mechanisms of the dam abutments and foundation were investigated. The test results indicate that the stability safety factors of the dam abutments and foundation range from 5.2 to 6.0. These research results provide an important scientific insight into the design, construction, and operation stages of this project.

  9. Test Methods and Protocols for Environmental and Safety Hazards Associated with Home Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Cautley, D.; Viner, J.; Lord, M.; Pearce, M.

    2012-12-01

    A number of health hazards and hazards to the durability of homes may be associated with energy retrofitting and home renovation projects. Among the hazards associated with energy retrofit work, exposure to radon is thought to cause more than 15,000 deaths per year in the U.S., while carbon monoxide poisoning results in about 20,000 injuries and 450 deaths per year. Testing procedures have been developed for identifying and quantifying hazards during retrofitting. These procedures commonly include a battery of tests to screen combustion appliances for safe operation, including worst case depressurization measurement, backdrafting (spillage) under depressurized or normal conditions, and carbon monoxide production.

  10. Validation of an Instrument and Testing Protocol for Measuring the Combinatorial Analysis Schema.

    Science.gov (United States)

    Staver, John R.; Harty, Harold

    1979-01-01

    Designs a testing situation to examine the presence of combinatorial analysis, to establish construct validity in the use of an instrument, Combinatorial Analysis Behavior Observation Scheme (CABOS), and to investigate the presence of the schema in young adolescents. (Author/GA)

  11. Retrofit of waste-to-energy facilities equipped with electrostatic precipitators. Volume III: Test protocol

    Energy Technology Data Exchange (ETDEWEB)

    Rigo, H.G. [Rigo & Rigo Associates, Inc., Berea, OH (US); Chandler, A.J. [A.J. Chandler & Associates, Inc., Toronto, Ontario (Canada)

    1996-04-01

    The American Society of Mechanical Engineers' [ASME] Center for Research and Technology Development [CRTD] has been awarded a subcontract by the National Renewable Energy Laboratory [NREL] to demonstrate the technical performance and viability of flue gas temperature control in combination with dry acid gas reagent and activated carbon injection at an existing electrostatic precipitator [ESP] equipped municipal waste combustor [MWC]. The objective of this proof-of-concept demonstration test is to economically and reliably meet 40 CFR 60 Subpart Cb Emissions Guidelines for MWC's at existing ESP equipped facilities. The effort is being directed by a Subcommittee of tile ASME Research Committee on Industrial and Municipal Wastes [RCIMW] chaired by Dave Hoecke. Mr. Greg Barthold of ASME/CRTD is the Project Manager. ASME/CRTD contracted with Rigo & Rigo Associates, Inc. in cooperation with A.J. Chandler & Associates, Ltd. to be the Principal Investigator for the project and manage the day-t o-day aspects of the program, conduct the testing reduce and interpret the data and prepare the report. Testing will be conducted at the 2 by 210 TPD, ESP equipped MWC at the Davis County Resource Recovery Facility in Layton, Utah. The test plan calls for duplicate metals (Cd, Pb and Hg), dioxin and acid gas runs.

  12. Testing protocol for predicting driven pile behavior within pre-bored soil : research project capsule.

    Science.gov (United States)

    2014-02-01

    The objective of this project is to compile the state-of-the-art and best practice : results available on the subject of pre-bored piles and develop a research and : instrumentation testing plan for fi eld data collection and select multiple pile : d...

  13. Prediction of pre-eclampsia: a protocol for systematic reviews of test accuracy

    Directory of Open Access Journals (Sweden)

    Khan Khalid S

    2006-10-01

    Full Text Available Abstract Background Pre-eclampsia, a syndrome of hypertension and proteinuria, is a major cause of maternal and perinatal morbidity and mortality. Accurate prediction of pre-eclampsia is important, since high risk women could benefit from intensive monitoring and preventive treatment. However, decision making is currently hampered due to lack of precise and up to date comprehensive evidence summaries on estimates of risk of developing pre-eclampsia. Methods/Design A series of systematic reviews and meta-analyses will be undertaken to determine, among women in early pregnancy, the accuracy of various tests (history, examinations and investigations for predicting pre-eclampsia. We will search Medline, Embase, Cochrane Library, MEDION, citation lists of review articles and eligible primary articles and will contact experts in the field. Reviewers working independently will select studies, extract data, and assess study validity according to established criteria. Language restrictions will not be applied. Bivariate meta-analysis of sensitivity and specificity will be considered for tests whose studies allow generation of 2 × 2 tables. Discussion The results of the test accuracy reviews will be integrated with results of effectiveness reviews of preventive interventions to assess the impact of test-intervention combinations for prevention of pre-eclampsia.

  14. Development and test of an evaluation protocol for heavy gas dispersion models

    NARCIS (Netherlands)

    Duijm, N.J.; Carissimo, B.; Mercer, A.; Bartholome, C.; Giesbrecht, H.

    1997-01-01

    In order to improve the quality (i.e. fitness-for-purpose) of models used to describe the atmospheric dispersion of heavy gas, an evaluation methodology has been developed and tested through a small evaluation exercise. This activity was carried out by the Heavy Gas Dispersion Expert Group, which

  15. Study protocol of psychometric properties of the Spanish translation of a competence test in evidence based practice: The Fresno test

    Directory of Open Access Journals (Sweden)

    Villafafila-Ferrero Rosa

    2009-02-01

    Full Text Available Abstract Background There are few high-quality instruments for evaluating the effectiveness of Evidence-Based Practice (EBP curricula with objective outcomes measures. The Fresno test is an instrument that evaluates most of EBP steps with a high reliability and validity in the English original version. The present study has the aims to translate the Fresno questionnaire into Spanish and its subsequent validation to ensure the equivalence of the Spanish version against the English original. Methods and design The questionnaire will be translated with the back translation technique and tested in Primary Care Teaching Units in Catalonia (PCTU. Participants will be: (a tutors of Family Medicine residents (expert group; (b Family Medicine residents in their second year of the Family Medicine training program (novice group, and (c Family Medicine physicians (intermediate group. The questionnaire will be administered before and after an educational intervention. The educational intervention will be an interactive four half-day sessions designed to develop the knowledge and skills required to EBP. Responsiveness statistics used in the analysis will be the effect size, the standardised response mean and Guyatt's method. For internal consistency reliability, two measures will be used: corrected item-total correlations and Cronbach's alpha. Inter-rater reliability will be tested using Kappa coefficient for qualitative items and intra-class correlation coefficient for quantitative items and the overall score. Construct validity, item difficulty, item discrimination and feasibility will be determined. Discussion The validation of the Fresno questionnaire into different languages will enable the expansion of the questionnaire, as well as allowing comparison between countries and the evaluation of different teaching models.

  16. Study protocol of psychometric properties of the Spanish translation of a competence test in evidence based practice: the Fresno test.

    Science.gov (United States)

    Argimon-Pallàs, Josep M; Flores-Mateo, Gemma; Jiménez-Villa, Josep; Pujol-Ribera, Enriqueta; Foz, Gonçal; Bundó-Vidiella, Magda; Juncosa, Sebastià; Fuentes-Bellido, Cruz M; Pérez-Rodríguez, Belén; Margalef-Pallarès, Francesc; Villafafila-Ferrero, Rosa; Forès-Garcia, Dolors; Roman-Martínez, Josep; Vilert-Garroga, Esther

    2009-02-24

    There are few high-quality instruments for evaluating the effectiveness of Evidence-Based Practice (EBP) curricula with objective outcomes measures. The Fresno test is an instrument that evaluates most of EBP steps with a high reliability and validity in the English original version. The present study has the aims to translate the Fresno questionnaire into Spanish and its subsequent validation to ensure the equivalence of the Spanish version against the English original. The questionnaire will be translated with the back translation technique and tested in Primary Care Teaching Units in Catalonia (PCTU). Participants will be: (a) tutors of Family Medicine residents (expert group); (b) Family Medicine residents in their second year of the Family Medicine training program (novice group), and (c) Family Medicine physicians (intermediate group). The questionnaire will be administered before and after an educational intervention. The educational intervention will be an interactive four half-day sessions designed to develop the knowledge and skills required to EBP. Responsiveness statistics used in the analysis will be the effect size, the standardised response mean and Guyatt's method. For internal consistency reliability, two measures will be used: corrected item-total correlations and Cronbach's alpha. Inter-rater reliability will be tested using Kappa coefficient for qualitative items and intra-class correlation coefficient for quantitative items and the overall score. Construct validity, item difficulty, item discrimination and feasibility will be determined. The validation of the Fresno questionnaire into different languages will enable the expansion of the questionnaire, as well as allowing comparison between countries and the evaluation of different teaching models.

  17. Amplitude and frequency changes in surface EMG of biceps femoris during five days Bruce Protocol treadmill test.

    Science.gov (United States)

    Jamaluddin, Fauzani N; Ahmad, Siti A; Noor, Samsul Bahari Mohd; Hassan, Wan Zuha Wan; Yaakob, Azhar; Adam, Yunus; Ali, Sawal H M

    2015-01-01

    Electromyography (EMG) is one of the indirect tools in indexing fatigue. Fatigue can be detected when there are changes on amplitude and frequency. However, various outcomes from literature make researchers conclude that EMG is not a reliable tool to measure fatigue. This paper investigates EMG behavior of biceps femoris in median frequency and mean absolute value during five days of Bruce Protocol treadmill test. Before that, surface EMG signals are filtered using band pass filter cut-off at 20-500Hz and are de-noised using db45 1-decimated wavelet transform. Five participants achieved more than 85% of their maximal heart rate during the running activity. The authors also consider other markers of fatigue such as performance, muscle soreness and lethargy as indicators to adaptation and maladaptation conditions. Result shows that turning points of median frequency and mean absolute value are very significant in indexing fatigue and indicators to adaptation of resistive training.

  18. Integrating usability testing and think-aloud protocol analysis with "near-live" clinical simulations in evaluating clinical decision support.

    Science.gov (United States)

    Li, Alice C; Kannry, Joseph L; Kushniruk, Andre; Chrimes, Dillon; McGinn, Thomas G; Edonyabo, Daniel; Mann, Devin M

    2012-11-01

    Usability evaluations can improve the usability and workflow integration of clinical decision support (CDS). Traditional usability testing using scripted scenarios with think-aloud protocol analysis provide a useful but incomplete assessment of how new CDS tools interact with users and clinical workflow. "Near-live" clinical simulations are a newer usability evaluation tool that more closely mimics clinical workflow and that allows for a complementary evaluation of CDS usability as well as impact on workflow. This study employed two phases of testing a new CDS tool that embedded clinical prediction rules (an evidence-based medicine tool) into primary care workflow within a commercial electronic health record. Phase I applied usability testing involving "think-aloud" protocol analysis of 8 primary care providers encountering several scripted clinical scenarios. Phase II used "near-live" clinical simulations of 8 providers interacting with video clips of standardized trained patient actors enacting the clinical scenario. In both phases, all sessions were audiotaped and had screen-capture software activated for onscreen recordings. Transcripts were coded using qualitative analysis methods. In Phase I, the impact of the CDS on navigation and workflow were associated with the largest volume of negative comments (accounting for over 90% of user raised issues) while the overall usability and the content of the CDS were associated with the most positive comments. However, usability had a positive-to-negative comment ratio of only 0.93 reflecting mixed perceptions about the usability of the CDS. In Phase II, the duration of encounters with simulated patients was approximately 12 min with 71% of the clinical prediction rules being activated after half of the visit had already elapsed. Upon activation, providers accepted the CDS tool pathway 82% of times offered and completed all of its elements in 53% of all simulation cases. Only 12.2% of encounter time was spent using the

  19. An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cuff Leak Tests.

    Science.gov (United States)

    Girard, Timothy D; Alhazzani, Waleed; Kress, John P; Ouellette, Daniel R; Schmidt, Gregory A; Truwit, Jonathon D; Burns, Suzanne M; Epstein, Scott K; Esteban, Andres; Fan, Eddy; Ferrer, Miguel; Fraser, Gilles L; Gong, Michelle Ng; Hough, Catherine L; Mehta, Sangeeta; Nanchal, Rahul; Patel, Sheena; Pawlik, Amy J; Schweickert, William D; Sessler, Curtis N; Strøm, Thomas; Wilson, Kevin C; Morris, Peter E

    2017-01-01

    Interventions that lead to earlier liberation from mechanical ventilation can improve patient outcomes. This guideline, a collaborative effort between the American Thoracic Society and the American College of Chest Physicians, provides evidence-based recommendations to optimize liberation from mechanical ventilation in critically ill adults. Two methodologists performed evidence syntheses to summarize available evidence relevant to key questions about liberation from mechanical ventilation. The methodologists appraised the certainty in the evidence (i.e., the quality of evidence) using the Grading of Recommendations, Assessment, Development, and Evaluation approach and summarized the results in evidence profiles. The guideline panel then formulated recommendations after considering the balance of desirable consequences (benefits) versus undesirable consequences (burdens, adverse effects, and costs), the certainty in the evidence, and the feasibility and acceptability of various interventions. Recommendations were rated as strong or conditional. The guideline panel made four conditional recommendations related to rehabilitation protocols, ventilator liberation protocols, and cuff leak tests. The recommendations were for acutely hospitalized adults mechanically ventilated for more than 24 hours to receive protocolized rehabilitation directed toward early mobilization, be managed with a ventilator liberation protocol, be assessed with a cuff leak test if they meet extubation criteria but are deemed high risk for postextubation stridor, and be administered systemic steroids for at least 4 hours before extubation if they fail the cuff leak test. The American Thoracic Society/American College of Chest Physicians recommendations are intended to support healthcare professionals in their decisions related to liberating critically ill adults from mechanical ventilation.

  20. Multi-Mission Earth Vehicle Subsonic Dynamic Stability Testing and Analyses

    Science.gov (United States)

    Glaab, Louis J.; Fremaux, C. Michael

    2013-01-01

    Multi-Mission Earth Entry Vehicles (MMEEVs) are blunt-body vehicles designed with the purpose of transporting payloads from outer space to the surface of the Earth. To achieve high-reliability and minimum weight, MMEEVs avoid use of limited-reliability systems, such as parachutes, retro-rockets, and reaction control systems and rely on the natural aerodynamic stability of the vehicle throughout the Entry, Descent, and Landing (EDL) phase of flight. The Multi-Mission Systems Analysis for Planetary Entry (M-SAPE) parametric design tool is used to facilitate the design of MMEEVs for an array of missions and develop and visualize the trade space. Testing in NASA Langley?s Vertical Spin Tunnel (VST) was conducted to significantly improve M-SAPE?s subsonic aerodynamic models. Vehicle size and shape can be driven by entry flight path angle and speed, thermal protection system performance, terminal velocity limitations, payload mass and density, among other design parameters. The objectives of the VST testing were to define usable subsonic center of gravity limits, and aerodynamic parameters for 6-degree-of-freedom (6-DOF) simulations, for a range of MMEEV designs. The range of MMEEVs tested was from 1.8m down to 1.2m diameter. A backshell extender provided the ability to test a design with a much larger payload for the 1.2m MMEEV.

  1. Performance of Momguard, a new non-invasive prenatal testing protocol developed in Korea

    OpenAIRE

    Lee, Mi-Young; Cho, Dae-Yeon; Won, Hye-Sung; Hwang, Ah Reum; Jeong, Bada; Kim, Jihun; Oh, Mijin

    2015-01-01

    Objective To evaluate the performance of Momguard, non-invasive prenatal test (NIPT) for detecting trisomy (T) 21, T18, T13, and sex-chromosome abnormalities recently developed in Korea. Methods This preliminary study formed part of a large prospective cohort study conducted at Asan Medical Center, Seoul, Korea. Only pregnant women who underwent both NIPT and confirmatory karyotyping were included in this study. NIPT results were compared with those of karyotype analyses. Results Among 93 eli...

  2. Standardised test protocol (Constant Score) for evaluation of functionality in patients with shoulder disorders

    DEFF Research Database (Denmark)

    Ban, Ilija; Troelsen, Anders; Christiansen, David Høyrup

    2013-01-01

    INTRODUCTION: The Constant Score (CS), developed as a scoring system to evaluate overall functionality of patients with shoulder disorders, is widely used but has been criticised for relying on an imprecise terminology and for lack of a standardised methodology. A modified guideline was therefore...... internationally for standardised assessment of the CS. Testing of validity, reliability and responsiveness of both versions needs to be done in future research. FUNDING: not relevant. TRIAL REGISTRATION: not relevant....

  3. Development of a field testing protocol for identifying Deepwater Horizon oil spill residues trapped near Gulf of Mexico beaches

    Science.gov (United States)

    Han, Yuling

    2018-01-01

    The Deepwater Horizon (DWH) accident, one of the largest oil spills in U.S. history, contaminated several beaches located along the Gulf of Mexico (GOM) shoreline. The residues from the spill still continue to be deposited on some of these beaches. Methods to track and monitor the fate of these residues require approaches that can differentiate the DWH residues from other types of petroleum residues. This is because, historically, the crude oil released from sources such as natural seeps and anthropogenic discharges have also deposited other types of petroleum residues on GOM beaches. Therefore, identifying the origin of these residues is critical for developing effective management strategies for monitoring the long-term environmental impacts of the DWH oil spill. Advanced fingerprinting methods that are currently used for identifying the source of oil spill residues require detailed laboratory studies, which can be cost-prohibitive. Also, most agencies typically use untrained workers or volunteers to conduct shoreline monitoring surveys and these worker will not have access to advanced laboratory facilities. Furthermore, it is impractical to routinely fingerprint large volumes of samples that are collected after a major oil spill event, such as the DWH spill. In this study, we propose a simple field testing protocol that can identify DWH oil spill residues based on their unique physical characteristics. The robustness of the method is demonstrated by testing a variety of oil spill samples, and the results are verified by characterizing the samples using advanced chemical fingerprinting methods. The verification data show that the method yields results that are consistent with the results derived from advanced fingerprinting methods. The proposed protocol is a reliable, cost-effective, practical field approach for differentiating DWH residues from other types of petroleum residues. PMID:29329313

  4. Development of a field testing protocol for identifying Deepwater Horizon oil spill residues trapped near Gulf of Mexico beaches.

    Science.gov (United States)

    Han, Yuling; Clement, T Prabhakar

    2018-01-01

    The Deepwater Horizon (DWH) accident, one of the largest oil spills in U.S. history, contaminated several beaches located along the Gulf of Mexico (GOM) shoreline. The residues from the spill still continue to be deposited on some of these beaches. Methods to track and monitor the fate of these residues require approaches that can differentiate the DWH residues from other types of petroleum residues. This is because, historically, the crude oil released from sources such as natural seeps and anthropogenic discharges have also deposited other types of petroleum residues on GOM beaches. Therefore, identifying the origin of these residues is critical for developing effective management strategies for monitoring the long-term environmental impacts of the DWH oil spill. Advanced fingerprinting methods that are currently used for identifying the source of oil spill residues require detailed laboratory studies, which can be cost-prohibitive. Also, most agencies typically use untrained workers or volunteers to conduct shoreline monitoring surveys and these worker will not have access to advanced laboratory facilities. Furthermore, it is impractical to routinely fingerprint large volumes of samples that are collected after a major oil spill event, such as the DWH spill. In this study, we propose a simple field testing protocol that can identify DWH oil spill residues based on their unique physical characteristics. The robustness of the method is demonstrated by testing a variety of oil spill samples, and the results are verified by characterizing the samples using advanced chemical fingerprinting methods. The verification data show that the method yields results that are consistent with the results derived from advanced fingerprinting methods. The proposed protocol is a reliable, cost-effective, practical field approach for differentiating DWH residues from other types of petroleum residues.

  5. Development and establishment of a protocol of an individual aggressiveness test in breeding does

    Directory of Open Access Journals (Sweden)

    I. Olivas

    2016-12-01

    Full Text Available The present work aims to define the optimal conditions to perform a resident-intruder test in individually housed breeding does as a measure of aggressiveness and describe the biological characteristics of aggressiveness in rabbit does: severity, frequency, duration and latency of aggressive events. Sixty-four nulliparous does at 90 d of age were used for this experiment, half (32 does as residents and the rest as intruders, testing them once a week for 14 wk. The time and duration of each aggressive behaviour was recorded and analysed to assess the aforementioned measures. According to the results, and regarding the studied effects, the origin of the animals caused no effect, whereas the level of aggressiveness seemed to be clearly increased in weeks 3-7 of the experiment, when animals were 110-140 d of age. In conclusion, a resident-intruder test lasting 1 min is enough to assess individual aggressiveness in adult breeding does, the response of which evolves with age and repetition.

  6. Developing an Innovative Field Expedient Fracture Toughness Testing Protocol for Concrete Materials

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jy-An John [ORNL; Liu, Ken C [ORNL; Naus, Dan J [ORNL

    2008-09-01

    The Spiral Notch Torsion Fracture Toughness Test (SNTT) was developed recently to determine the intrinsic fracture toughness (KIC) of structural materials. The SNTT system operates by applying pure torsion to uniform cylindrical specimens with a notch line that spirals around the specimen at a 45 pitch. KIC values are obtained with the aid of a three-dimensional finite-element computer code, TOR3D-KIC. The SNTT method is uniquely suitable for testing a wide variety of materials used extensively in pressure vessel and piping structural components and weldments. Application of the method to metallic, ceramic, and graphite materials has been demonstrated. One important characteristic of SNTT is that neither a fatigue precrack or a deep notch are required for the evaluation of brittle materials, which significantly reduces the sample size requirement. In this paper we report results for a Portland cement-based mortar to demonstrate applicability of the SNTT method to cementitious materials. The estimated KIC of the tested mortar samples with compressive strength of 34.45 MPa was found to be 0.19 MPa m.

  7. A Study Protocol for Testing the Effectiveness of User-Generated Content in Reducing Excessive Consumption.

    Science.gov (United States)

    Herziger, Atar; Benzerga, Amel; Berkessel, Jana; Dinartika, Niken L; Franklin, Matija; Steinnes, Kamilla K; Sundström, Felicia

    2017-01-01

    Excessive consumption is on the rise, as is apparent in growing financial debt and global greenhouse gas emissions. Voluntary simplicity, a lifestyle choice of reduced consumption and sustainable consumer behavior, provides a potential solution for excessive consumers. However, voluntary simplicity is unpopular, difficult to adopt, and under researched. The outlined research project will test a method of promoting voluntary simplicity via user-generated content, thus mimicking an existing social media trend (Minimalism) in an empirical research design. The project will test (a) whether the Minimalism trend could benefit consumers interested in reducing their consumption, and (b) whether self-transcendence (i.e., biospheric) and self-enhancement (i.e., egoistic and hedonic) values and goals have a similar impact in promoting voluntary simplicity. A one-week intervention program will test the efficacy of watching user-generated voluntary simplicity videos in reducing non-essential consumption. Each of the two intervention conditions will present participants with similar tutorial videos on consumption reduction (e.g., decluttering, donating), while priming the relevant values and goals (self-transcendence or self-enhancement). These interventions will be compared to a control condition, involving no user-generated content. Participants will undergo baseline and post-intervention evaluations of: voluntary simplicity attitudes and behaviors, buying and shopping behaviors, values and goals in reducing consumption, and life satisfaction. Experience sampling will monitor affective state during the intervention. We provide a detailed stepwise procedure, materials, and equipment necessary for executing this intervention. The outlined research design is expected to contribute to the limited literature on voluntary simplicity, online behavioral change interventions, and the use of social marketing principles in consumer interventions.

  8. A Study Protocol for Testing the Effectiveness of User-Generated Content in Reducing Excessive Consumption

    Directory of Open Access Journals (Sweden)

    Atar Herziger

    2017-06-01

    Full Text Available Excessive consumption is on the rise, as is apparent in growing financial debt and global greenhouse gas emissions. Voluntary simplicity, a lifestyle choice of reduced consumption and sustainable consumer behavior, provides a potential solution for excessive consumers. However, voluntary simplicity is unpopular, difficult to adopt, and under researched. The outlined research project will test a method of promoting voluntary simplicity via user-generated content, thus mimicking an existing social media trend (Minimalism in an empirical research design. The project will test (a whether the Minimalism trend could benefit consumers interested in reducing their consumption, and (b whether self-transcendence (i.e., biospheric and self-enhancement (i.e., egoistic and hedonic values and goals have a similar impact in promoting voluntary simplicity. A one-week intervention program will test the efficacy of watching user-generated voluntary simplicity videos in reducing non-essential consumption. Each of the two intervention conditions will present participants with similar tutorial videos on consumption reduction (e.g., decluttering, donating, while priming the relevant values and goals (self-transcendence or self-enhancement. These interventions will be compared to a control condition, involving no user-generated content. Participants will undergo baseline and post-intervention evaluations of: voluntary simplicity attitudes and behaviors, buying and shopping behaviors, values and goals in reducing consumption, and life satisfaction. Experience sampling will monitor affective state during the intervention. We provide a detailed stepwise procedure, materials, and equipment necessary for executing this intervention. The outlined research design is expected to contribute to the limited literature on voluntary simplicity, online behavioral change interventions, and the use of social marketing principles in consumer interventions.

  9. Tests for predicting complications of pre-eclampsia: A protocol for systematic reviews

    Directory of Open Access Journals (Sweden)

    O'Brien Shaughn

    2008-08-01

    Full Text Available Abstract Background Pre-eclampsia is associated with several complications. Early prediction of complications and timely management is needed for clinical care of these patients to avert fetal and maternal mortality and morbidity. There is a need to identify best testing strategies in pre eclampsia to identify the women at increased risk of complications. We aim to determine the accuracy of various tests to predict complications of pre-eclampsia by systematic quantitative reviews. Method We performed extensive search in MEDLINE (1951–2004, EMBASE (1974–2004 and also will also include manual searches of bibliographies of primary and review articles. An initial search has revealed 19500 citations. Two reviewers will independently select studies and extract data on study characteristics, quality and accuracy. Accuracy data will be used to construct 2 × 2 tables. Data synthesis will involve assessment for heterogeneity and appropriately pooling of results to produce summary Receiver Operating Characteristics (ROC curve and summary likelihood ratios. Discussion This review will generate predictive information and integrate that with therapeutic effectiveness to determine the absolute benefit and harm of available therapy in reducing complications in women with pre-eclampsia.

  10. Reliability of a novel testing protocol to assess upper-body strength qualities in elite athletes.

    Science.gov (United States)

    Young, Kieran P; Haff, G Gregory; Newton, Robert U; Sheppard, Jeremy M

    2014-09-01

    The purpose of this study was to evaluate the reliability of an isometric-bench-press (IBP) test performed across 4 elbow angles and a ballistic bench throw (BBT) using a relative load, as well as evaluating the reliability of the dynamic strength index (DSI: BBT peak force/IBP peak force). Twenty-four elite male athletes performed the IBP and a 45% 1-repetition-maximum BBT on 2 separate days with 48 h between testing occasions. Peak force, peak power, peak velocity, peak displacement, and peak rate of force development (PRFD) were assessed using a force plate and linear position transducer. Reliability was assessed by intraclass correlation (ICC), coefficient of variation (%CV) and typical error. Performance measures in the BBT, such as peak force, peak velocity, peak power, and peak displacement, were considered reliable (ICC = .85-.92, %CV = 1.7-3.3), while PRFD was not (ICC = .43, %CV = 4.1). Similarly, for the IBP, peak force across all angles was considered reliable (ICC = .89-.97, %CV = 1.2-1.6), while PRFD was not (ICC = .56-.65, %CV = 0.5-7.6). The DSI was also reliable (ICC = .93, %CV = 3.5). Performance measures such as peak force in the IBP and BBT are reliable when assessing upper-body pressing-strength qualities in elite male athletes. Furthermore, the DSI is reliable and could potentially be used to detect qualities of relative deficiency and guide specific training interventions.

  11. Stability of the offset V-osteotomy. Test jig development and saw bone model assessment.

    Science.gov (United States)

    Gonda, Elizabeth; Bauer, Gary R; Hillstrom, Howard J; Song, Jinsup; Cho, Helen H; Lundberg, Lori A

    2002-02-01

    In the offset V-bunionectomy used for hallux valgus repair, both the Kalish and the Vogler variations have a long dorsal arm, but the apex is more distal in the Kalish procedure. This study investigated the effect that pin orientation and location of the osteotomy apex have on weightbearing stability. The authors studied saw bone models that were loaded to failure in an Instron 4201 materials testing machine and, in addition, designed, fabricated, and used a unique jig assembly to help minimize data variability. Statistically significant differences were found between the surgical techniques and pin orientations: the Kalish osteotomy was stronger than the Vogler procedure, and in both osteotomies, the plantarly directed Kirschner wire orientation was stronger than the dorsally directed orientation.

  12. Testing baseline stability of some neutron monitors in Europe, Africa, and Asia

    Science.gov (United States)

    Ahluwalia, H. S.; Ygbuhay, R. C.

    2013-06-01

    For six decades, the global network of neutron monitors (NMs) has provided a continuous stream of very valuable data to the heliophysics community, leading to many insights into the myriad modes of charged particle transport in the tangled magnetic fields that permeate the 3D heliosphere. Earlier, Ahluwalia and Ygbuhay (2012) reported on the drifts in some high latitude NM counting rates in the American zone. We continue our enquiry by testing the stability of the counting rate baselines of some NMs operating in Europe, Africa, and Asia. The data from these detectors have been extremely valuable for the short-term time variation studies, but caution is advised in using the data for long-term studies from NMs with baselines that are drifting for cause(s) unknown.

  13. Use of Small-Angle Neutron Scattering in Testing the Stability of Ferrofluids

    CERN Document Server

    Balasoiu, M; Avdeev, M V; Aksenov, V L; Khokhryakov, A A; Bica, L D; Hasegan, D; Török, G; Rosta, L

    2004-01-01

    Stability of ferrofluids - colloidal solutions of magnetic particles covered with surfactants - is the main characteristic that determines the possibility to exploit ferrofluids in different industrial and biomedical applications. Small-angle neutron scattering (SANS) can be effectively used to reveal the aggregation and its change with time in ferrofluids under the action of magnetic field. Despite the fact that in most cases the detailed description of scattering is complicated, one can judge whether a ferrofluid is stable or not by simple analysis of changes in the mean scattering intensity. The advantages of SANS are that industrial samples can be tested without any additional modifications, as well as the real-time experiments with any magnetic load can be easily performed. Examples for a number of ferrofluids are given.

  14. Development of a Ground Test and Analysis Protocol to Support NASA's NextSTEP Phase 2 Habitation Concepts

    Science.gov (United States)

    Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Gernhardt, Michael L.

    2018-01-01

    The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support extensive human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts have been tasked with developing the ground test protocol that will serve as the primary means by which these Phase 2 prototype habitats will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational products, tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the NextSTEP Phase 2 Habitation Concepts is to consistently evaluate the different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3.

  15. Formulation, stability testing, and analytical characterization of melatonin-based preparation for clinical trial

    Directory of Open Access Journals (Sweden)

    Samira Filali

    2017-08-01

    Full Text Available A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens (0.5 mg, 2 mg, and 6 mg daily for one month. The objectives of present study were to (i prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and (ii carry out a stability study in order to determine a use-by-date. Validation of preparation process was claimed as ascertained by mass uniformity of hard capsules. Multicomponent analysis by attenuated total reflectance Fourier transformed infrared (ATR-FTIR of melatonin/microcrystalline cellulose mixture allowed to identify and quantify relative content of active pharmaceutical ingredients and excipients. Absolute melatonin content analysis by high performance liquid chromatography in 0.5 mg and 6 mg melatonin capsules was 93.6%±4.1% and 98.7%±6.9% of theoretical value, respectively. Forced degradation study showed a good separation of melatonin and its degradation products. The capability of the method was 15, confirming a risk of false negative <0.01%. Stability test and dissolution test were compliant over 18 months of storage with European Pharmacopoeia. Preparation of melatonin hard capsules was completed manually and melatonin in hard capsules was stable for 18 months, in spite of low doses of active ingredient. ATR-FTIR offers a real alternative to HPLC for quality control of high-dose melatonin hard capsules before the release of clinical batches.

  16. Toward an optimal geomagnetic field intensity determination technique: Testing the IZZI protocol

    Science.gov (United States)

    Yu, Y.; Tauxe, L.

    2004-12-01

    Paleointensity determinations based on double heating techniques (Aitken, Coe, and Thellier) are generally considered to be functionally interchangeable, producing equally reliable paleointensity estimates. To investigate this premise, we have developed a simple mathematical model. We find that both the zero-field first and in-field first methods have a strong angular dependence on the laboratory field (parallel, orthogonal, and anti-parallel) while the two in-field steps method is independent of the direction of the laboratory-produced field. Contrary to common practice, each method yields quite different outcomes if the condition of reciprocity of blocking and unblocking temperatures is not met, even with marginal (10%) tails of partial thermoremanence. By far the best approach, however, is to alternatethe infield-zerofield (IZ) steps with zerofield-infield (ZI) steps. We tested the IZZI method associated with the partial thermoremanent magnetization (pTRM) tail check. As predicted, the IZZI method shows a strong angular dependence, resulting from the undemagnetized portions of pTRM tails. We also tested two fundamental assumptions embedded in Thellier experiments, the initial state dependence and the effect of multi-cycle heat treatment. We observed that the magnitude of pTRMs with initial state of thermal demagnetization was larger than that of pTRMs in Thellier analysis. A multi-cycle Thellier analysis on coarse-grained magnetites progressively produces more intense pTRMs and progressively erases more pTRM tails. Both pre-history and multi-cycle dependence will likely to enhance the non-linear features of the Arai plot for coarse-grained magnetites.

  17. Laboratory tests of the response stability of the ATLAS Tile Calorimeter photomultipliers

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00216540; The ATLAS collaboration; Leone, Sandra; Scuri, Fabrizio

    2017-01-01

    High performance of the ATLAS Tile Calorimeter response is achieved with a multi- stage calibration. One step of the calibration is based on measurements of the response to laser pulse excitation of the PMTs used to read out the calorimeter cells. A facility to study the PMT stability response is operating in the PISA-INFN laboratories since 2015. Goals of the tests are to study the time evolution of the PMT response as a function of the integrated anode charge and to compare test bench results with the observed response drifts of the Tile Calorimeter PMTs during LHC Run I and Run II. A new statistical approach was used to measure the drift of the absolute PMT gain. A new procedure which combines studies of the time evolution of the global PMT responses and of the individual PMT gains was adopted to derive the evolution of the cathode quantum efficiency. The experimental setup of the Pisa facility is described and the first results obtained by testing about 30 PMTs Hamamatsu model R7877 (a special evolution f...

  18. Laboratory tests of the response stability of the ATLAS Tile Calorimeter photomultipliers

    CERN Document Server

    Kazanin, Vassili; The ATLAS collaboration; Scuri, Fabrizio

    2017-01-01

    High performance of the ATLAS Tile Calorimeter response is achieved with a multi-stage calibration. One step of the calibration is based on measurements of the response to laser pulse excitation of the PMTs used to read out the calorimeter cells. A facility to study the PMT stability response is operating in the PISA-INFN laboratories since 2015. Goals of the tests are to study the time evolution of the PMT response as a function of the integrated anode charge and to compare test bench results with the observed response drifts of the Tile Calorimeter PMTs during LHC Run I and Run II. A new statistical approach was used to measure the drift of the absolute PMT gain. A new procedure which combines studies of the time evolution of the global PMT responses and of the individual PMT gains was adopted to derive the evolution of the cathode quantum efficiency. The experimental setup of the Pisa facility is described and the first results obtained by testing about 30 PMTs Hamamatsu model R7877 (a special evolution fo...

  19. Thermal stability test of UO{sub 2}-doped pellet manufactured at INB

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Diogo R., E-mail: diogoribeiro@inb.gov.br [Indústrias Nucleares do Brasil S.A. (FCN/INB), Resende, RJ (Brazil). Fábrica de Combustível Nuclear; Freitas, Artur C., E-mail: artur.freitas@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    The thermal stability test of UO{sub 2}-doped pellet manufactured at INB was carried out in order to analyze the resintering behavior. This analysis is fundamental for predicting dimensional behavior during irradiation. INB commonly performs resintering test to qualify its production lots, and the same methodology was applied to UO{sub 2}-doped pellets. In this preliminary study, three sets of experiments have been made: 1) without any chemical additive (Z test, the standard UO{sub 2} pellets - undoped); 2) UO{sub 2} pellets doped with 0.1, 0.2 and 0.3 wt% of Al{sub 2}O{sub 3}; and 3) 0.1, 0.2 and 0.3 wt% of Nb{sub 2}O{sub 5}. The preliminary results showed an increase in sintered density in all resintering experiments. So as to obtain the percentage increase, the theoretical densities (g/cm{sup 3} and %TD) were calculated based on the undoped UO{sub 2} pellets. All samples increased in a range of 0.27 to 0.32 %TD the out-pile densification during the resintering process. However, the Z(Nb)3 test showed the lowest value of 0.08 %TD, which is not in agreement with the INB specification limits. The sintered density of this test (0.3 wt% niobia) was 96.15% TD. This fact might be related to the competitive mechanism between Kirkendall effect, forming porosity owing to niobium solubilization on UO{sub 2} matrix, and densification process as a result of uranium diffusivity. Thus, the densification was only 0.08 %TD in Z(Nb)3 sample. All the other samples were in agreement with INB specification. (author)

  20. Stability Tests of Positive Fractional Continuous-time Linear Systems with Delays

    Directory of Open Access Journals (Sweden)

    Tadeusz Kaczorek

    2013-06-01

    Full Text Available Necessary and sufficient conditions for the asymptotic stability of positive fractional continuous-time linear systems with many delays are established. It is shown that: 1 the asymptotic stability of the positive fractional system is independent of their delays, 2 the checking of the asymptotic stability of the positive fractional systems with delays can be reduced to checking of the asymptotic stability of positive standard linear systems without delays.

  1. Development and testing of an implementation strategy for a complex housing intervention: protocol for a mixed methods study.

    Science.gov (United States)

    Watson, Dennis P; Young, Jeani; Ahonen, Emily; Xu, Huiping; Henderson, Macey; Shuman, Valery; Tolliver, Randi

    2014-10-17

    There is currently a lack of scientifically designed and tested implementation strategies. Such strategies are particularly important for highly complex interventions that require coordination between multiple parts to be successful. This paper presents a protocol for the development and testing of an implementation strategy for a complex intervention known as the Housing First model (HFM). Housing First is an evidence-based practice for chronically homeless individuals demonstrated to significantly improve a number of outcomes. Drawing on practices demonstrated to be useful in implementation and e-learning theory, our team is currently adapting a face-to-face implementation strategy so that it can be delivered over a distance. Research activities will be divided between Chicago and Central Indiana, two areas with significantly different barriers to HFM implementation. Ten housing providers (five from Chicago and five from Indiana) will be recruited to conduct an alpha test of each of four e-learning modules as they are developed. Providers will be requested to keep a detailed log of their experience completing the modules and participate in one of two focus groups. After refining the modules based on alpha test results, we will test the strategy among a sample of four housing organizations (two from Chicago and two from Indiana). We will collect and analyze both qualitative and quantitative data from administration and staff. Measures of interest include causal factors affecting implementation, training outcomes, and implementation outcomes. This project is an important first step in the development of an evidence-based implementation strategy to increase scalability and impact of the HFM. The project also has strong potential to increase limited scientific knowledge regarding implementation strategies in general.

  2. Testing a Dutch web-based tailored lifestyle programme among adults: a study protocol

    Directory of Open Access Journals (Sweden)

    van Osch Liesbeth ADM

    2011-02-01

    Full Text Available Abstract Background Smoking, high alcohol consumption, unhealthy eating habits and physical inactivity often lead to (chronic diseases, such as cardiovascular diseases and cancer. Tailored online interventions have been proven to be effective in changing health behaviours. The aim of this study is to test and compare the effectiveness of two different tailoring strategies for changing lifestyle compared to a control group using a multiple health behaviour web-based approach. Methods In our Internet-based tailored programme, the five lifestyle behaviours of smoking, alcohol intake, fruit consumption, vegetable consumption, and physical activity are addressed. This randomized controlled trial, conducted among Dutch adults, includes two experimental groups (i.e., a sequential behaviour tailoring condition and a simultaneous behaviour tailoring condition and a control group. People in the sequential behaviour tailoring condition obtain feedback on whether their lifestyle behaviours meet the Dutch recommendations. Using a step-by-step approach, they are stimulated to continue with a computer tailored module to change only one unhealthy behaviour first. In the course of the study, they can proceed to change a second behaviour. People in the simultaneous behaviour tailoring condition receive computer tailored feedback about all their unhealthy behaviours during their first visit as a stimulation to change all unhealthy behaviours. The experimental groups can re-visit the website and can then receive ipsative feedback (i.e., current scores are compared to previous scores in order to give feedback about potential changes. The (difference in effectiveness of the different versions of the programme will be tested and compared to a control group, in which respondents only receive a short health risk appraisal. Programme evaluations will assess satisfaction with and appreciation and personal relevance of the intervention among the respondents. Finally

  3. Testing the Community-Based Learning Collaborative (CBLC) implementation model: a study protocol.

    Science.gov (United States)

    Hanson, Rochelle F; Schoenwald, Sonja; Saunders, Benjamin E; Chapman, Jason; Palinkas, Lawrence A; Moreland, Angela D; Dopp, Alex

    2016-01-01

    (weekly/monthly online surveys; pre-post surveys; interviews) and newly collected quantitative (monthly surveys) and qualitative (key informant interviews) data and social network analysis to test whether CBLC strategies are associated with penetration and sustainment of TF-CBT; and (2) Use existing quantitative quality improvement (weekly/monthly on-line surveys; pre/post surveys) and newly collected qualitative (key informant interviews) data and social network analysis to test whether CBLC strategies are associated with increased IOR and IC intensity. The proposed research leverages an on-going, statewide implementation initiative to generate evidence about implementation strategies needed to make trauma-focused EBTs more accessible to children. This study also provides feasibility data to inform an effectiveness trial that will utilize a time-series design to rigorously evaluate the CBLC model as a mechanism to improve access and sustained use of EBTs for children.

  4. Protocol of a test of hearing health education programs for farm and rural youth.

    Science.gov (United States)

    McCullagh, Marjorie C; Banerjee, Tanima; Yang, James

    2015-10-16

    Farm and rural youth have frequent exposure to hazardous noise on the farm and recreationally, and have an increased prevalence of noise-induced hearing loss. There is a lack of programs to prepare this high-risk population to use hearing conservation strategies. The purpose of this project is to test innovative hearing health education programs delivered to a large target group and to determine the effectiveness and sustainability of these programs in promoting hearing health among farm and rural youth. Specifically, this project includes: a) an interactive face-to-face informational program alone, b) an interactive face-to-face informational program followed by an Internet-based booster, and c) a no-intervention control. Sites will include selected affiliates of a major farm youth safety education organization. Data will be collected at baseline, 3, and 12 months. A linear mixed model will be used to compare the effectiveness of the three interventions over time. Descriptive statistics will be used to compare program costs and sustainability ratings. Outcomes of this project will provide knowledge necessary to implement quality and cost-effective services to farm and rural youth, a high-risk and underserved population, that can be implemented and sustained after the study is completed. Clinicaltrials.gov NCT02472821 Registered 09 Jun, 2015.

  5. ACUTE EFFECTS OF THREE DIFFERENT STRETCHING PROTOCOLS ON THE WINGATE TEST PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Bruno L. Franco

    2012-03-01

    Full Text Available The purpose of this study was to examine the acute effects of different stretching exercises on the performance of the traditional Wingate test (WT. Fifteen male participants performed five WT; one for familiarization (FT, and the remaining four after no stretching (NS, static stretching (SS, dynamic stretching (DS, and proprioceptive neuromuscular facilitation (PNF. Stretches were targeted for the hamstrings, quadriceps, and calf muscles. Peak power (PP, mean power (MP, and the time to reach PP (TP were calculated. The MP was significantly lower when comparing the DS (7.7 ± 0.9 W/kg to the PNF (7.3 ± 0.9 W/kg condition (p < 0.05. For PP, significant differences were observed between more comparisons, with PNF stretching providing the lowest result. A consistent increase of TP was observed after all stretching exercises when compared to NS. The results suggest the type of stretching, or no stretching, should be considered by those who seek higher performance and practice sports that use maximal anaerobic power.

  6. Performance of Momguard, a new non-invasive prenatal testing protocol developed in Korea.

    Science.gov (United States)

    Lee, Mi-Young; Cho, Dae-Yeon; Won, Hye-Sung; Hwang, Ah Reum; Jeong, Bada; Kim, Jihun; Oh, Mijin

    2015-09-01

    To evaluate the performance of Momguard, non-invasive prenatal test (NIPT) for detecting trisomy (T) 21, T18, T13, and sex-chromosome abnormalities recently developed in Korea. This preliminary study formed part of a large prospective cohort study conducted at Asan Medical Center, Seoul, Korea. Only pregnant women who underwent both NIPT and confirmatory karyotyping were included in this study. NIPT results were compared with those of karyotype analyses. Among 93 eligible cases, NIPT results could not be obtained in one case due to a low fetal cell-free DNA fraction. Based on NIPT, eight cases of fetal aneuploidies, including T21 (n=5), T18 (n=2), and T13 (n=1), were identified. For T21 and T18, the sensitivity and specificity of NIPT were both 100%, with a false-positive and false-negative rate of 0% and a positive-predictive value of 100%. One patient classified as having intermediate risk for T13 by NIPT was confirmed to have T13 by karyotyping, and there were no false-negative cases. No cases of sex-chromosome anomalies were detected by NIPT or karyotyping during the study period. Momguard is a reliable screening tool for detecting T21 and T18. For T13 and sex-chromosome anomalies, further prospective studies are necessary to confirm its utility.

  7. Homosexuality via canalized sexual development: a testing protocol for a new epigenetic model.

    Science.gov (United States)

    Rice, William R; Friberg, Urban; Gavrilets, Sergey

    2013-09-01

    We recently synthesized and reinterpreted published studies to advance an epigenetic model for the development of homosexuality (HS). The model is based on epigenetic marks laid down in response to the XX vs. XY karyotype in embryonic stem cells. These marks boost sensitivity to testosterone in XY fetuses and lower it in XX fetuses, thereby canalizing sexual development. Our model predicts that a subset of these canalizing epigenetic marks stochastically carry over across generations and lead to mosaicism for sexual development in opposite-sex offspring--the homosexual phenotype being one such outcome. Here, we begin by outlining why HS has been under-appreciated as a commonplace phenomenon in nature, and how this trend is currently being reversed in the field of neurobiology. We next briefly describe our epigenetic model of HS, develop a set of predictions, and describe how epigenetic profiles of human stem cells can provide for a strong test of the model. © 2013 The Authors. Bioessays published by WILEY Periodicals, Inc.

  8. Repeated Measurement of the Components of Attention with Young Children Using the Attention Network Test: Stability, Isolability, Robustness, and Reliability

    Science.gov (United States)

    Ishigami, Yoko; Klein, Raymond M.

    2015-01-01

    The current study examined the robustness, stability, reliability, and isolability of the attention network scores (alerting, orienting, and executive control) when young children experienced repeated administrations of the child version of the Attention Network Test (ANT; Rueda et al., 2004). Ten test sessions of the ANT were administered to 12…

  9. Reduction and technical simplification of testing protocol for walking based on repeatability analyses: An Interreg IVa pilot study

    Directory of Open Access Journals (Sweden)

    Nejc Sarabon

    2010-12-01

    Full Text Available The aim of this study was to define the most appropriate gait measurement protocols to be used in our future studies in the Mobility in Ageing project. A group of young healthy volunteers took part in the study. Each subject carried out a 10-metre walking test at five different speeds (preferred, very slow, very fast, slow, and fast. Each walking speed was repeated three times, making a total of 15 trials which were carried out in a random order. Each trial was simultaneously analysed by three observers using three different technical approaches: a stop watch, photo cells and electronic kinematic dress. In analysing the repeatability of the trials, the results showed that of the five self-selected walking speeds, three of them (preferred, very fast, and very slow had a significantly higher repeatability of the average walking velocity, step length and cadence than the other two speeds. Additionally, the data showed that one of the three technical methods for gait assessment has better metric characteristics than the other two. In conclusion, based on repeatability, technical and organizational simplification, this study helped us to successfully define a simple and reliable walking test to be used in the main study of the project.

  10. An investigation into the stability and sterility of citric acid solutions used for cough reflex testing.

    Science.gov (United States)

    Falconer, James R; Wu, Zimei; Lau, Hugo; Suen, Joanna; Wang, Lucy; Pottinger, Sarah; Lee, Elaine; Alazawi, Nawar; Kallesen, Molly; Gargiulo, Derryn A; Swift, Simon; Svirskis, Darren

    2014-10-01

    Citric acid is used in cough reflex testing in clinical and research settings to assess reflexive cough in patients at risk of swallowing disorders. To address a lack of knowledge in this area, this study investigated the stability and sterility of citric acid solutions. Triplicate solutions of citric acid (0.8 M) in isotonic saline were stored at 4 ± 2 °C for up to 28 days and analysed by high-performance liquid chromatography. Microbiological sterility of freshly prepared samples and bulk samples previously used for 2 weeks within the hospital was determined using a pour plate technique. Microbial survival in citric acid was determined by inoculating Staphylococcus aureus, Escherichia coli, or Candida albicans into citric acid solution and monitoring the number of colony-forming units/mL over 40 min. Citric acid solutions remained stable at 4 °C for 28 days (98.4 ± 1.8 % remained). The freshly prepared and clinical samples tested were sterile. However, viability studies revealed that citric acid solution allows for the survival of C. albicans but not for S. aureus or E. coli. The microbial survival study showed that citric acid kills S. aureus and E. coli but has no marked effect on C. albicans after 40 min. Citric acid samples at 0.8 M remained stable over the 4-week testing period, with viable microbial cells absent from samples tested. However, C. albicans has the ability to survive in citric acid solution if inadvertently introduced in practice. For this reason, in clinical and research practice it is suggested to use single-use aliquots prepared aseptically which can be stored for up to 28 days at 4 °C.

  11. A new improved multicopter chassis structure tested on slope stability monitoring

    Science.gov (United States)

    Rossi, Guglielmo; Tanteri, Luca; Salvatici, Teresa; Scaduto, Gabriele; Tacconi Stefanelli, Carlo; Casagli, Nicola; Moretti, Sandro

    2017-04-01

    The multicopter has an increasing role in remote sensing and aerial photography. The piloting ease and the mechanical simplicity are the main reasons for drone diffusion as a hobby and for professional use. Usually multicopters have a "spider" structure with a central body and many radial arms that support the propulsion device. To improve the structure of the existing multicopter, the Department of Earth Sciences of Florence (DST) has developed and patented a new type of chassis structure that allows us to overcome some critical issues for scientific and heavy payload or long flight applications. The drone has an innovative perimetric chassis that fully supports flight dynamics. The new structure allows us to obtain high flight performance combined with low vibration transmission to the carried instruments. The new patented structure is implemented in two new prototypes of high performance drones completely developed by the Department of Earth Sciences of Florence: Saturn 2 and Saturn mini X-21. Saturn 2 is a high performance multi-role drone capable of carrying up to 14 kg of scientific instruments. Saturn Mini X-21 is a high performance drone, entirely 3D printed and specialized for digital and 3D rapid mapping. The Saturn mini X-21 was especially developed to obtain for the first time, by a drone, a 3D high resolution digital model for slope monitoring purposes of the Stromboli Sciara del Fuoco, a large inaccessible area that presents harsh flight conditions such as high persistent wind, rotors, volcanic ash and saltiness. The Saturn drones are mainly developed and tested, all around software and hardware, on slope stability monitoring. Four test cases are proposed, which were performed during the development and testing phase: a large area 3D survey (Scillato - Sicily), a harsh condition 3D survey (Stromboli -Sicily), a multitemporal 3D survey (Ricasoli - Tuscany) and the testing phase of measurement performed by onboard radar equipment.

  12. Lab scale testing of novel natural analog in situ stabilization agents

    International Nuclear Information System (INIS)

    Shaw, P.

    1997-01-01

    This report summarizes the laboratory-scale test results on several novel in situ treatment and stabilization agents for buried hazardous and radioactive waste. Paraffin, hematite and phosphate materials were examined when combined with soil and other wastes representative of what might be present at buried waste DOE sites. Hematite was made from the reaction of agricultural iron and lime slurries to form gypsum and iron oxide/hydroxide. Common household paraffin was melted, both with and without a zeolitic additive, waste added and then cooled. Magnesium phosphate was made from the reaction of magnesium oxide and phosphoric acid or potassium biphosphate to form, magnesium phosphate. All were tested with soil and some with additional waste sumulants such as ash, machine oil and nitrate salts. The following laboratory-generated data indicate that all waste encapsulation materials tested are appropriate materials, for field in situ testing. Compressive strengths of treated Idaho National Engineering and Environment Laboratory (INEEL) soil and the waste encapsulation material were sufficient to prevent collapse of the void space in waste, i.e., greater than the NRC 60 psi minimum. The mineralogy and microstructure of hematite was amorphous but should progress to an interlocking crystalline solid. Phosphate was crystalline with characteristics of higher temperature ceramics. Paraffin is non crystalline but encapsulates even very fine grained INEEL soils. Each agent appears to be chemically and physically inert to possible waste materials such as, nitrates and machine cutting oil. Two of the agents hematite and phosphate react favorably with ash increasing the metals retention at higher waste loadings than Portland cement. Hematite, phosphate and zeolite decrease leaching of most hazardous metals from waste when compared to untreated waste and soil. Solution pH, time for reaction initiation, and viscosity values are conducive to jet-grouting application

  13. Stability test for amorphous materials in humidity controlled 96-well plates by near-infrared spectroscopy.

    Science.gov (United States)

    Otsuka, Makoto; Tanabe, Hideaki

    2012-03-01

    The purpose of this research is to apply near infrared spectrometry (NIR) with chemoinformetrics to predict the change of crystalline properties of indomethacin (IMC) amorphous under various levels of relative humidity storage conditions. Stability test for amorphous and meta-stable polymorphic forms was performed in humidity controlled the modified 96-well quartz plates containing various kinds of saturated salt solutions (0-100% of relative humidity (RH)) by NIR spectroscopy. Amorphous form was obtained melt product to pour into liquid nitrogen and after then ground. Samples were stored at 25°C in the 6-well plates at various levels of RH. The spectra of the powder samples were measured by the reflectance FT-NIR spectrometer. The second derivative spectra of form α showed specific absorption peaks at 4980, 6036, 7296 and 8616 cm-1 and that of form γ showed those at 5020, 5028, 7344, 7428 and 8436 cm-1. After storage at less than 50% RH, the peak intensities at 5020, 5028, 7344, 7428 and 8436 cm-1 of the amorphous solid increased with increasing of storage time. However, the peak intensity at 4980, 6036 and 7296 cm-1 increased at more than 50% RH Please check and confirm the edit. The results suggested that at lower humidity, the IMC amorphous solid transformed into form γ, but it transformed into form α at more than high humidity. It is possible that crystalline stability of the pharmaceutical preparations could be predicted by using humidity controlled 96-well plates and reflectance NIR-chemoinformetric methods.

  14. Reliability and Practicality of the Core Score: Four Dynamic Core Stability Tests Performed in a Physician Office Setting.

    Science.gov (United States)

    Friedrich, Jason; Brakke, Rachel; Akuthota, Venu; Sullivan, William

    2017-07-01

    Pilot study to determine the practicality and inter-rater reliability of the "Core Score," a composite measure of 4 clinical core stability tests. Repeated measures. Academic hospital physician clinic. 23 healthy volunteers with mean age of 32 years (12 females, 11 males). All subjects performed 4 core stability maneuvers under direct observation from 3 independent physicians in sequence. Inter-rater reliability and time necessary to perform examination. The Core Score scale is 0 to 12, with 12 reflecting the best core stability. The mean composite score of all 4 tests for all subjects was 9.54 (SD, 1.897; range, 4-12). The intraclass correlation coefficients (ICC 1,1) for inter-rater reliability for the composite Core Score and 4 individual tests were 0.68 (Core Score), 0.14 (single-leg squat), 0.40 (supine bridge), 0.69 (side bridge), and 0.46 (prone bridge). The time required for a single examiner to assess a given subject's core stability in all 4 maneuvers averaged 4 minutes (range, 2-6 minutes). Even without specialized equipment, a clinically practical and moderately reliable measure of core stability may be possible. Further research is necessary to optimize this measure for clinical application. Despite the known value of core stability to athletes and patients with low back pain, there is currently no reliable and practical means for rating core stability in a typical office-based practice. This pilot study provides a starting point for future reliability research on clinical core stability assessments.

  15. Results of Long-Term Stability Tests Performed for the Eutectics Co-C and Pt-C

    Science.gov (United States)

    Wang, T.; Bai, C.; Dong, W.; Yuan, Z.; Bloembergen, P.; Liu, F.

    2011-08-01

    The stability of the Co-C and Pt-C eutectic fixed points is investigated in this article. Six cells were employed for the testing. Two existing cells, a Co-C cell with a C/C sheet incorporated and a Pt-C cell equipped with a graphite sleeve that had been previously aged, were studied to determine the presence of anomalous drifts or degrading robustness that may possibly appear when the testing period is extended. The stability of four cells of a new design, a Co-C cell and three Pt-C cells, which were constructed in a hybrid manner, to include a sleeve, foil lining, and two of them with a cavity support, were likewise tested. Results show that different designs of Pt-C cells can exhibit good stability. However, for Co-C cells, the cavity rift remains a problem. The possible reasons for this rift and methods for increasing cell life are discussed.

  16. Test Framing Generates a Stability Bias for Predictions of Learning by Causing People to Discount their Learning Beliefs

    Science.gov (United States)

    Ariel, Robert; Hines, Jarrod C.; Hertzog, Christopher

    2014-01-01

    People estimate minimal changes in learning when making predictions of learning (POLs) for future study opportunities despite later showing increased performance and an awareness of that increase (Kornell & Bjork, 2009). This phenomenon is conceptualized as a stability bias in judgments about learning. We investigated the malleability of this effect, and whether it reflected people’s underlying beliefs about learning. We manipulated prediction framing to emphasize the role of testing vs. studying on memory and directly measured beliefs about multi-trial study effects on learning by having participants construct predicted learning curves before and after the experiment. Mean POLs were more sensitive to the number of study-test opportunities when performance was framed in terms of study benefits rather than testing benefits and POLs reflected pre-existing beliefs about learning. The stability bias is partially due to framing and reflects discounted beliefs about learning benefits rather than inherent belief in the stability of performance. PMID:25067885

  17. Functional testing and return to sport following stabilization surgery for recurrent lateral patellar instability in competitive athletes.

    Science.gov (United States)

    Krych, Aaron J; O'Malley, Michael P; Johnson, Nick R; Mohan, Rohith; Hewett, Timothy E; Stuart, Michael J; Dahm, Diane L

    2018-03-01

    Medial patellofemoral ligament (MPFL) reconstruction and tibial tubercle osteotomy are commonly used to treat recurrent lateral patellar instability, yet there are limited available data on return to sport (RTS) following these procedures. The purpose of this study is to evaluate patient factors associated with excellent functional outcomes, including successful RTS, following surgical stabilization including MPFL reconstruction in competitive athletes with recurrent lateral patellar instability. Athletes undergoing primary MPFL reconstruction for recurrent lateral instability from 2005 to 2013 were identified at a single institution. Concomitant procedures, such as tibial tubercle osteotomy (TTO), were included. Patient demographic information, including BMI, gender, age, and pre-injury Tegner score, was recorded. In addition, radiographs were reviewed for pre-operative patellar height (Caton-Deschamps index) and trochlear dysplasia (Dejour classification). All patients underwent a standardized rehabilitation/post-operative protocol, with isokinetic strength and functional testing being performed at 6 months post-operatively. Final Tegner scores, RTS status, subjective instability ratings, and Kujala scores were collected at a minimum of 2 years. Chi-squared analysis for categorical variables and Wilcoxon rank-sum analysis for continuous variables were used to determine the relationship between the previously mentioned patient and knee characteristics with isokinetic data, RTS status, or Kujala scores. Thirty-nine athletes (23 male, 16 female) at a mean age of 17.5 ± 2.9 years (range, 13-26) underwent primary MPFL reconstruction (32 autografts, seven allografts) for recurrent patellar instability with a mean follow-up of 47.0 ± 16.4 months. Sixteen patients (41%) underwent concomitant tibial tubercle osteotomies. Isokinetic data collected at 6 months post-operatively demonstrated mean knee flexion and extension strength deficits of 15.8 ± 10.1% and

  18. Influence of cardiopulmonary exercise testing protocol and resting VO(2) assessment on %HR(max), %HRR, %VO(2max) and %VO(2)R relationships.

    Science.gov (United States)

    Cunha, F A; Midgley, A W; Monteiro, W D; Farinatti, P T V

    2010-05-01

    The findings of previous studies investigating the strength of the relationships between the percentages of maximal heart rate (%HR(max)), heart rate reserve (%HRR), maximal oxygen uptake (%VO(2max)), and oxygen uptake reserve (%VO(2)R) have been equivocal. This inconsistency between studies could largely be due to differences in methodology. The purpose of this study was therefore to determine whether different VO(2max) test protocols and resting VO(2) assessment influence the relationships between the %HR(max), %HRR, %VO(2max), and %VO(2)R. Thirty-three young men performed maximal treadmill protocols (ramp, Bruce) to assess HR(max) and VO(2max). Resting VO(2) was assessed as follows: a) resting VO(2standard), using strict criteria (24 h exercise abstention, alcohol, soft drinks, or caffeine; 8 h fasting; 30 min assessment); b) resting VO(2sitting) and; c) resting VO(2standing) (both 5 min before exercise testing). The %HRR was closer to %VO(2max) than to %VO(2)R, especially in the ramp protocol (p<0.001). In the Bruce protocol, relationships were closer to the identity line, and there was no significant difference between %HRR and %VO(2max), or %VO(2)R. The VO(2max) was significantly higher in the ramp protocol compared to the Bruce protocol (p<0.001). In both protocols resting VO(2) assessment produced no significant difference in the intercepts and slopes of the %HRR-%VO(2)R relationships obtained from individual regression models. The %VO(2)R calculated using resting VO(2standard) was closer to %HRR compared to VO(2sitting) and VO(2standing). The premise that %HRR is more strongly related to %VO(2)R than to %VO(2max) was not confirmed. Methodological differences should be considered when interpreting previous studies investigating %HR(max), %HRR, %VO(2max), and %VO(2)R relationships.

  19. Application of the accelerated test Rancimat to evaluate oxidative stability of dried microencapsulated oils

    Directory of Open Access Journals (Sweden)

    Márquez-Ruiz, G.

    2000-08-01

    Full Text Available The objective of this work was to apply the oxidative test Rancimat to dried microencapsulated oils (DMO, with special emphasis on assessing the efficacy of natural antioxidants. DMO were prepared by freeze-drying emulsions containing sodium caseinate, lactose and fish or sunflower oils, with and without added the antioxidant mixture ALT (ascorbic acid, lecithin and tocopherol. Under the Rancimat working conditions selected for testing DMO (5 g sample, 100ºC and 20 L air/h, excellent repeatability was obtained. The antioxidant effect of ALT was much higher in bulk fish oil than in its counterpart DMO, either in Rancimat or at 30ºC in the dark. Further experiments using Rancimat showed that the moderate increase in stability of DMO added ALT was only attributable to tocopherol while the synergistic actions of lecithin and ascorbic acid were not observed, their action probably depending on their location and orientation in these complex lipid systems. This test enabled to compare monophasic (bulk oils and DMO-extracted oils and heterophasic lipidic systems (DMO and DMO devoid of the accessible, free oil fraction, thus offering a rapid means to examine the influence of oil distribution and partitioning of antioxidants on oxidative stability.El objetivo de este trabajo es la aplicación del test Rancimat a aceites microencapsulados, con especial interés en el estudio de la eficacia de antioxidantes naturales. Los aceites microencapsulados en matriz seca (DMO se prepararon mediante liofilización de emulsiones constituidas por caseinato sódico, lactosa y aceite de pescado o girasol, con o sin la mezcla antioxidante ALT (ácido ascórbico, lecitina y tocoferol. En las condiciones seleccionadas en Rancimat (5 g de muestra, 100ºC y 20 L/h aire se obtuvo excelente repetitividad. La mezcla ALT fue mucho más efectiva en el aceite de pescado que en su correspondiente DMO, tanto en Rancimat como a 30ºC en la oscuridad. Otros experimentos en

  20. Study of necking stability in tension test of zircaloy-2, on range from 170 0 C to 620 0 C

    International Nuclear Information System (INIS)

    Okuda, M.Y.

    1975-01-01

    The objective of this work is to study necking behavior of Zircaloy-2 in a tension test in which the temperature range varies from 170 0 C to 620 0 C by means of a model. This model provides strain rate variations in the beginning of necking and the parameters in the / necking stability. A new parameter Ψ is presented which permits necking / stability description in metals by means of a simple tension test. It is also proceeded a behavioral study of ε versus ε curve after necking formation. (author)

  1. The effects of sweep numbers per average and protocol type on the accuracy of the p300-based concealed information test.

    Science.gov (United States)

    Dietrich, Ariana B; Hu, Xiaoqing; Rosenfeld, J Peter

    2014-03-01

    In the first of two experiments, we compared the accuracy of the P300 concealed information test protocol as a function of numbers of trials experienced by subjects and ERP averages analyzed by investigators. Contrary to Farwell et al. (Cogn Neurodyn 6(2):115-154, 2012), we found no evidence that 100 trial based averages are more accurate than 66 or 33 trial based averages (all numbers led to accuracies of 84-94 %). There was actually a trend favoring the lowest trial numbers. The second study compared numbers of irrelevant stimuli recalled and recognized in the 3-stimulus protocol versus the complex trial protocol (Rosenfeld in Memory detection: theory and application of the concealed information test, Cambridge University Press, New York, pp 63-89, 2011). Again, in contrast to expectations from Farwell et al. (Cogn Neurodyn 6(2):115-154, 2012), there were no differences between protocols, although there were more irrelevant stimuli recognized than recalled, and irrelevant 4-digit number group stimuli were neither recalled nor recognized as well as irrelevant city name stimuli. We therefore conclude that stimulus processing in the P300-based complex trial protocol-with no more than 33 sweep averages-is adequate to allow accurate detection of concealed information.

  2. Protocol: Testing the Relevance of Acupuncture Theory in the Treatment of Myofascial Pain in the Upper Trapezius Muscle.

    Science.gov (United States)

    Elsdon, Dale S; Spanswick, Selina; Zaslawski, Chris; Meier, Peter C

    2017-01-01

    A protocol for a prospective single-blind parallel four-arm randomized placebo-controlled trial with repeated measures was designed to test the effects of various acupuncture methods compared with sham. Eighty self-selected participants with myofascial pain in the upper trapezius muscle were randomized into four groups. Group 1 received acupuncture to a myofascial trigger point (MTrP) in the upper trapezius. Group 2 received acupuncture to the MTrP in addition to relevant distal points. Group 3 received acupuncture to the relevant distal points only. Group 4 received a sham treatment to both the MTrP and distal points using a deactivated acupuncture laser device. Treatment was applied four times within 2 weeks with outcomes measured throughout the trial and at 2 weeks and 4 weeks posttreatment. Outcome measurements were a 100-mm visual analog pain scale, SF-36, pressure pain threshold, Neck Disability Index, the Upper Extremity Functional Index, lateral flexion in the neck, McGill Pain Questionnaire, Massachusetts General Hospital Acupuncture Sensation Scale, Working Alliance Inventory (short form), and the Credibility Expectance Questionnaire. Two-way analysis of variance (ANOVA) with repeated measures were used to assess the differences between groups. Copyright © 2017 Medical Association of Pharmacopuncture Institute. Published by Elsevier B.V. All rights reserved.

  3. Pilot Testing a Cognitive-Behavioral Protocol on Psychosocial Predictors of Exercise, Nutrition, Weight, and Body Satisfaction Changes in a College-Level Health-Related Fitness Course

    Science.gov (United States)

    Annesi, James J.; Howton, Amy; Johnson, Ping H.; Porter, Kandice J.

    2015-01-01

    Objective: Small-scale pilot testing of supplementing a required college health-related fitness course with a cognitive-behavioral exercise-support protocol (The Coach Approach). Participants: Three classes were randomly assigned to Usual processes (n = 32), Coach Approach-supplemented: Mid-size Groups (n = 32), and Coach Approach-supplemented:…

  4. Thermal-hydraulic stability tests for newly designed BWR rod bundle (step-III fuel type A)

    International Nuclear Information System (INIS)

    Mitsutake, T.; Chuman, K.; Miura, S.; Morooka, S.; Moriya, K.; Kitamura, H.; Toba, A.; Omoto, A.

    2004-01-01

    Thermal-hydraulic stability tests have been performed on electrically heated bundles to simulate the newly designed Boiling Water Reactor (BWR) fuels in a parallel channel test loop. The objective of the current experimental program is to investigate how the newly designed bundle could improve the thermal-hydraulic stability. Measurements of the thermal-hydraulic instability thresholds in two vertical rod bundles have been conducted in steam-water two-phase flow conditions at the TOSHIBA test loop. Fluid conditions were BWR operating conditions of 7 MPa system pressure, 1.0-2.0x10 6 kg/m 2 /h inlet mass flux and 28-108 kJ/kg inlet subcooling. The parallel channel test loop consists of a main bundle of 3x3 indirectly heated rods of 1/9 symmetry of 9x9 full lattice and a bypass bundle of 8x8. These are both simulated BWR rod bundles in respect of rod diameter, heated length, rod configuration, fuel rod spacer, core inlet hydraulic resistance and upper tie plate. There are three types of the 3x3 test bundles with different configurations of a part length rod of two-thirds the length of the other rods and an axial power shape. The design innovation of the part length rod for a 9x9 lattice development, though addition of more fuel rods increases bundle pressure drop, reduces pressure drop in the two-phase portion of the bundle, and enhances the thermal hydraulic stability. Through the experiments, the parameter dependency on the channel stability threshold is obtained for inlet subcooling, inlet mass flux, inlet flow resistance, axial power shape and part length rod. The main conclusion is that the stability threshold is about 10% greater with the part length rod than without the part length rod. The new BWR bundle consisting of the part length rod has been verified in respect of thermal hydraulic stability performance. (author)

  5. Results of a Saxitoxin Proficiency Test Including Characterization of Reference Material and Stability Studies

    Directory of Open Access Journals (Sweden)

    Kirsi Harju

    2015-11-01

    Full Text Available A saxitoxin (STX proficiency test (PT was organized as part of the Establishment of Quality Assurance for the Detection of Biological Toxins of Potential Bioterrorism Risk (EQuATox project. The aim of this PT was to provide an evaluation of existing methods and the European laboratories’ capabilities for the analysis of STX and some of its analogues in real samples. Homogenized mussel material and algal cell materials containing paralytic shellfish poisoning (PSP toxins were produced as reference sample matrices. The reference material was characterized using various analytical methods. Acidified algal extract samples at two concentration levels were prepared from a bulk culture of PSP toxins producing dinoflagellate Alexandrium ostenfeldii. The homogeneity and stability of the prepared PT samples were studied and found to be fit-for-purpose. Thereafter, eight STX PT samples were sent to ten participating laboratories from eight countries. The PT offered the participating laboratories the possibility to assess their performance regarding the qualitative and quantitative detection of PSP toxins. Various techniques such as official Association of Official Analytical Chemists (AOAC methods, immunoassays, and liquid chromatography-mass spectrometry were used for sample analyses.

  6. Unmarried cohabitation and union stability: testing the role of diffusion using data from 16 European countries

    NARCIS (Netherlands)

    Liefbroer, A.C.; Dourleijn, E.

    2006-01-01

    Cohabitors and married people who cohabited before marriage have higher risks of union dissolution than people who married without prior cohabitation. However, these differences in union stability vary markedly between countries. We hypothesize that the impact of cohabitation on union stability

  7. Stabilization of inorganic mixed waste to pass the TCLP and STLC tests using clay and pH-insensitive additives

    Energy Technology Data Exchange (ETDEWEB)

    Bowers, J.S.; Anson, J.R.; Painter, S.M. [Lawrence Livermore National Lab., CA (United States)] [and others

    1995-12-31

    Stabilization is a best demonstrated available technology, or BDAT. This technology traps toxic contaminants in a matrix so that they do not leach into the environment. The stabilization process routinely uses pozzolanic materials. Portland cement, fly ash-lime mixes, gypsum cements, and clays are some of the most common materials. In many instances, materials that can pass the Toxicity Characteristic Leaching Procedure (TCLP the federal leach test) or the Soluble Threshold Leachate Concentration (STLC the California leach test) must have high concentrations of lime or other caustic material because of the low pH of the leaching media. Both leaching media, California`s and EPA`s, have a pH of 5.0. California uses citric acid and sodium citrate while EPA uses acetic acid and sodium acetate. The concentration in the leachate is approximately ten times higher for the STLC procedure than the TCLP. These media can form ligands that provide excellent metal leaching. Because of the aggressive nature of the leaching medium, stabilized wastes in many cases will not pass the leaching tests. At the Lawrence Livermore National Laboratory (LLNL), additives such as dithiocarbamates and thiocarbonates, which are pH-insensitive and provide resistance to ligand formation, are used in the waste stabilization process. Attapulgite, montmorillonite, and sepiolite clays are used because they are forgiving (recipe can be adjusted before the matrix hardens) when formulating a stabilization matrix, and they have a neutral pH. By using these clays and additives, LLNL`s highly concentrated wastewater treatment sludges have passed the TCLP and STLC tests. The most frequently used stabilization process consists of a customized recipe involving waste sludge, clay and dithiocarbamate salt, mixed with a double planetary mixer into a pasty consistency. TCLP and STLC data on this waste matrix have shown that the process matrix meets land disposal requirements.

  8. Development and Testing of a Literature Search Protocol for Evidence Based Nursing: An Applied Student Learning Experience

    OpenAIRE

    Andy Hickner; Christopher R. Friese; Margaret Irwin

    2011-01-01

    Objective – The study aimed to develop a search protocol and evaluate reviewers' satisfaction with an evidence-based practice (EBP) review by embedding a library science student in the process.Methods – The student was embedded in one of four review teams overseen by a professional organization for oncology nurses (ONS). A literature search protocol was developed by the student following discussion and feedback from the review team. Organization staff provided process feedback. Reviewers from...

  9. Design of durability test protocol for vehicular fuel cell systems operated in power-follow mode based on statistical results of on-road data

    Science.gov (United States)

    Xu, Liangfei; Reimer, Uwe; Li, Jianqiu; Huang, Haiyan; Hu, Zunyan; Jiang, Hongliang; Janßen, Holger; Ouyang, Minggao; Lehnert, Werner

    2018-02-01

    City buses using polymer electrolyte membrane (PEM) fuel cells are considered to be the most likely fuel cell vehicles to be commercialized in China. The technical specifications of the fuel cell systems (FCSs) these buses are equipped with will differ based on the powertrain configurations and vehicle control strategies, but can generally be classified into the power-follow and soft-run modes. Each mode imposes different levels of electrochemical stress on the fuel cells. Evaluating the aging behavior of fuel cell stacks under the conditions encountered in fuel cell buses requires new durability test protocols based on statistical results obtained during actual driving tests. In this study, we propose a systematic design method for fuel cell durability test protocols that correspond to the power-follow mode based on three parameters for different fuel cell load ranges. The powertrain configurations and control strategy are described herein, followed by a presentation of the statistical data for the duty cycles of FCSs in one city bus in the demonstration project. Assessment protocols are presented based on the statistical results using mathematical optimization methods, and are compared to existing protocols with respect to common factors, such as time at open circuit voltage and root-mean-square power.

  10. Number of test trials needed for performance stability and interrater reliability of the one leg stand test in patients with a major non-traumatic lower limb amputation

    DEFF Research Database (Denmark)

    Kristensen, Morten Tange; Nielsen, Anni Østergaard; Madsen Topp, Ulla

    2014-01-01

    Balance is beneficial for daily functioning of patients with a lower limb amputation and sometimes assessed by the one-leg stand test (OLST). The aims of the study were to examine (1) the number of trials needed to achieve performance stability, (2) the interrater reliability of the OLST...... in patients with a major non-traumatic lower limb amputation, and (3) to provide a test procedure....

  11. Immunochemical faecal occult blood tests have superior stability and analytical performance characteristics over guaiac-based tests in a controlled in vitro study.

    LENUS (Irish Health Repository)

    Lee, Chun Seng

    2011-06-01

    The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compare analytical imprecision and other characteristics between two commercially available iFOBT methods.

  12. A Novel and Validated Protocol for Performing MIC Tests to Determine the Susceptibility of Piscirickettsia salmonis Isolates to Florfenicol and Oxytetracycline

    Directory of Open Access Journals (Sweden)

    Sergio Contreras-Lynch

    2017-07-01

    Full Text Available This paper presents a validated protocol, using a novel, specifically formulated medium, to perform broth microdilution antimicrobial susceptibility assays of the salmonid bacterial pathogen Piscirickettsia salmonis. The minimum inhibitory concentrations (MIC for florfenicol and oxytetracycline against 58 P. salmonis isolates recovered from various outbreaks occurred in Chilean salmonid farms were determined using this protocol. Normalized resistance interpretation (NRI analysis was applied to these data to calculate appropriate protocol-specific epidemiological cut-off values. These cut-off values allow the isolates to be categorized as either fully susceptible wild type (WT members of this species, or as manifesting reduced susceptibility non-wild type (NWT. The distribution of MIC values of florfenicol was bimodal and the distribution of the normalized values for the putative WT observation had a standard deviation of 0.896 log2 μg mL-1. This analysis calculated a cut-off value of ≤0.25 μg mL-1 and categorized 33 (56% of the isolates as manifesting reduced susceptibility to florfenicol. For the oxytetracycline MIC data the NRI analysis also treated the distribution as bimodal. The distribution of the normalized values for the putative WT observation had a standard deviation of 0.951 log2 μg mL-1. This analysis gave a cut-off value of ≤0.5 μg mL-1 and categorized five isolates (9% as manifesting reduced susceptibility to oxytetracycline. The susceptibility testing protocol developed in this study was capable of generating MIC data from all the isolates tested. On the basis of the precision of the data it generated, and the degree of separation of values for WT and NWT it achieved, it is argued that this protocol has the performance characteristics necessary for it to be considered as a standard protocol.

  13. Test performance of faecal occult blood testing for the detection of bowel cancer in people with chronic kidney disease (DETECT protocol

    Directory of Open Access Journals (Sweden)

    Williams Narelle

    2011-06-01

    Full Text Available Abstract Background Cancer is a major cause of mortality and morbidity in patients with chronic kidney disease (CKD. In patients without kidney disease, screening is a major strategy for reducing the risk of cancer and improving the health outcomes for those who developed cancers by detecting treatable cancers at an early stage. Among those with CKD, the effectiveness, the efficacy and patients' preferences for cancer screening are unknown. Methods/Design This work describes the protocol for the DETECT study examining the effectiveness, efficiency and patient's perspectives of colorectal cancer screening using immunochemical faecal occult blood testing (iFOBT for people with CKD. The aims of the DETECT study are 1 to determine the test performance characteristics of iFOBT screening in individuals with CKD, 2 to estimate the incremental costs and health benefits of iFOBT screening in CKD compared to no screening and 3 to elicit patients' perspective for colorectal cancer screening in the CKD population. Three different study designs will be used to explore the uncertainties surrounding colorectal cancer screening in CKD. A diagnostic test accuracy study of iFOBT screening will be conducted across all stages of CKD in patients ages 35-70. Using individually collected direct healthcare costs and outcomes from the diagnostic test accuracy study, cost-utility and cost-effective analyses will be performed to estimate the costs and health benefits of iFOBT screening in CKD. Qualitative in-depth interviews will be undertaken in a subset of participants from the diagnostic test accuracy study to investigate the perspectives, experiences, attitudes and beliefs about colorectal cancer screening among individuals with CKD. Discussion The DETECT study will target the three major unknowns about early cancer detection in CKD. Findings from our study will provide accurate and definitive estimates of screening efficacy and efficiency for colorectal cancer, and

  14. [The effect of prostitution on the stability of romantic relationships. Empirical testing of an evolutionary model].

    Science.gov (United States)

    Meskó, Norbert; Láng, András; Bernáth, László

    2012-01-01

    Until now prostitution has only been explained from two evolutionary points of view. According to the short-term mate choice strategy approach motives for seeking prostitutes are to be found in the nature of male sexuality. Another theory - the evolutionary interpretation of female promiscuity's motivational base - indirectly completes the understanding of prostitution. This theory emphasizes the adaptive benefits of female promiscuity under certain circumstances. The aim of our study was to test a third idea (Adaptive Support Theory), according to which women in long-term relationships support their partners' (husbands') sexual relations with prostitutes. University female students (n=208, age mean±SD=23.55±7.13, min=18, max=50) completed our questionnaire. Female participants are presumed to recognize the advantages and threats of their partners' sexual relations with prostitutes compared to other possible forms of betrayal. Hence it is hypothesized that women overtly support the possibility of their partners' relations with prostitutes. Our results show that women are able to assess the favorable and unfavorable effects of their partners' relations with prostitutes. At the same time they do not directly support this form of betrayal over other possibilities. However, female participants were more approving of their partners' relations with prostitutes (in a thought- experiment), than they guessed their partner would demand such services. According to our model women living in long-term relationship are adaptively interested in their partner's cheating on them with a prostitute (rather than engaging in other kinds of sexual relations), because this finance based external sexual liaison is the least threatening for the stability of the long-term relationship.

  15. Bone cement penetration pattern and primary stability testing in keeled and pegged glenoid components.

    Science.gov (United States)

    Raiss, Patric; Pape, Guido; Kleinschmidt, Kerstin; Jäger, Sebastian; Sowa, Boris; Jakubowitz, Eike; Loew, Markus; Bruckner, Thomas; Rickert, Markus

    2011-07-01

    It has been proposed that bone mineral density has an influence on cement penetration in hip and knee arthroplasty. The hypotheses of this study were that: 1) there is a negative correlation between bone mineral density (BMD) and cement penetration in cemented glenoid components; and 2) that implant design has an influence on cement penetration into the glenoid bone. BMD of 10 pairs of fresh frozen scapulas was measured. Micro-computed tomography (micro-CT) scans in 3 different sections were analyzed after implantation of keeled and pegged glenoid components using a 3(rd)-generation cementing technique with a vacuum mixing system. Cement penetration was analyzed and correlated with BMD. Pull-out strength testing was performed to analyze primary stability. The overall peak BMD was 0.6 [g/cm(2)] (range, 0.33-0.98). A strong negative correlation between BMD and mean cement penetration was found for the peg (R(2) = -.83; P penetration was 78.4 mm(2) (range, 60.6-94.2) in the keel and 113.9 mm(2) (range, 78.2-143.4) in the peg group (P < .0001). In all cases, the components were pulled out of the cement mantle, whereas the bone-cement interfaces remained intact. The mean pull-out strength was 1093N (764-1343N) for keeled and 884N (650-1264N) for pegged components (P < .05). A modern cementing technique, leading to a deep bonding between bone and cement, is crucial to prevent loosening of glenoid components. The findings of this study might help us to better understand the results of follow-up studies of cemented glenoid implants. Our results could be helpful for the choice of implants in patients with poor bone quality like osteoporosis or rheumatoid arthritis. Copyright © 2011 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  16. The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus.

    Science.gov (United States)

    Abram, Katrin; Bohne, Silvia; Bublak, Peter; Karvouniari, Panagiota; Klingner, Carsten M; Witte, Otto W; Guntinas-Lichius, Orlando; Axer, Hubertus

    2016-01-01

    Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. The gait score showed a significant improvement 24 h after spinal tap test in all subtests and in the sum score (p tap test. CDP showed significant improvements after spinal tap test in the Sensory Organization Tests 2 (p = 0.017), 4 (p = 0.001), and 5 (p = 0.009) and the composite score (p = 0.01). Patients showed best performance in somatosensory and worst performance in vestibular dominated tests. Vestibular dominated tests did not improve significantly after spinal tap test, while somatosensory and visual dominated tests did. Postural stability in NPH is predominantly affected by deficient vestibular functions, which did not improve after spinal tap test. Conditions which improved best were mainly independent from visual control and are based on proprioceptive functions.

  17. Cement stabilization of road pavement materials: laboratory testing programme phase 1

    CSIR Research Space (South Africa)

    Paige-Green, P

    2004-06-01

    Full Text Available of seven of the available cements on two typical South African construction materials. Chemical analyses of the two materials showed no incidences of unusual components that would lead to specific problems during cement stabilization of the materials...

  18. Intelligence Tests with Higher G-Loadings Show Higher Correlations with Body Symmetry: Evidence for a General Fitness Factor Mediated by Developmental Stability

    Science.gov (United States)

    Prokosch, M.D.; Yeo, R.A.; Miller, G.F.

    2005-01-01

    Just as body symmetry reveals developmental stability at the morphological level, general intelligence may reveal developmental stability at the level of brain development and cognitive functioning. These two forms of developmental stability may overlap by tapping into a ''general fitness factor.'' If so, then intellectual tests with higher…

  19. Long-term impact of pre-operative physical rehabilitation protocol on the 6-min walk test of patients with adolescent idiopathic scoliosis: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    V.L. dos Santos Alves

    2015-05-01

    Full Text Available Background: Monitored physical activities in patients with adolescent idiopathic scoliosis (AIS have been shown to improve physical performance, endurance and cardiopulmonary function and may be assessed by the 6-min walk test (6MWT. We aimed to evaluate the long-term results of the 6MWT after a rehabilitation protocol employed before surgical correction for AIS. Methods: This prospective randomized clinical trial studied the impact of a 4-month pre-operative physical rehabilitation protocol on post-operative cardiopulmonary function and physical endurance, by using the 6MWT, in patients with AIS submitted to surgical correction, comparing them to matched controls without physical rehabilitation. Studied variables were heart and respiratory rate, systolic and diastolic blood pressure, peripheral blood oxygen saturation, Borg score, and distance walked. Patients were assessed at baseline, after 4 months of rehabilitation, and 3, 6 and 12 months post-operatively. Results: A total of 50 patients with AIS were included in the study and allocated blindly, by simple randomization, into either one of the two groups, with 25 patients each: study group (pre-operative physical rehabilitation and control group. The physical rehabilitation protocol promoted significant progressive improvement in heart and respiratory rate, peripheral blood oxygen saturation, distance walked, and level of effort assessed by the Borg scale after surgery. Conclusions: Post-surgical recovery, evaluated by 6MWT, was significantly better in patients who underwent a 4-month pre-operative physical rehabilitation protocol. Keywords: Scoliosis, Exercise, Exercise movement techniques, Exercise therapy, Exercise test

  20. Whole-body PET acceptance test in 2D and 3D using NEMA NU 2-2001 protocol

    International Nuclear Information System (INIS)

    Sharma, Shamurailatpam Dayananda; Deshpande, D.; Prasad, R.; Shetye, Bina; Rangarajan, V.; Shrivastava, S.K.; Dinshaw, K.A.

    2007-01-01

    Integrated PET/CT has emerged as an integral component of oncology management because of its unique potential of providing both functional and morphological images in a single imaging session. In this work, performance of the 'bismuth germinate (BGO) crystal'-based PET of a newly installed Discovery ST PET/CT was evaluated in 2D and 3D mode for whole-body scanning using National Electrical Manufacturers Association (NEMA) NU 2-2001 protocol and the recommended phantoms. During the entire measurements, the system operates with an energy window of 375-650 keV and 11.7 ns coincidence time window. The set of tests performed were spatial resolution, sensitivity, scatter fraction (SF) and counting rate performance. The average transaxial and axial spatial resolution measured as full width at half maximum (FWHM) of the point spread function at 1 cm (and 10 cm) off-axis was 0.632 (0.691) and 0.491 (0.653) cm in 2D and 0.646 (0.682) and 0.54 (0.601) cm in 3D respectively. The average sensitivity for the two radial positions (R = 0 cm and R = 10 cm) was 2.56 (2.63) cps/kBq in 2D and 11.85 (12.14) cps/kBq in 3D. The average scatter fraction was 19.79% in 2D and 46.19% in 3D. The peak noise equivalent counting rate (NECR) evaluated with single random subtraction was 89.41 kcps at 49 kBq/cc in 2D and 60 kcps at 12 kBq/cc in 3D acquisition mode. The NECR with delayed random subtraction was 61.47 kcps at 40.67 kBq/cc in 2D and 45.57 kcps at 16.45 kBq/cc in 3D. The performance of the PET scanner was satisfactory within the manufacturer-specified limits. The test result of PET shows excellent system sensitivity with relatively uniform resolution throughout the FOV, making this scanner highly suitable for whole-body studies. (author)

  1. The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus

    Directory of Open Access Journals (Sweden)

    Katrin Abram

    2016-09-01

    Full Text Available Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP, and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in all subtests and in the sum score (p Conclusion: Postural stability in NPH is predominantly affected by deficient vestibular functions, which did not improve after spinal tap test. Conditions which improved best were mainly independent from visual control and are based on proprioceptive functions.

  2. Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.

    Science.gov (United States)

    Parmar, Mahesh Kb; Sydes, Matthew R; Cafferty, Fay H; Choodari-Oskooei, Babak; Langley, Ruth E; Brown, Louise; Phillips, Patrick Pj; Spears, Melissa R; Rowley, Sam; Kaplan, Richard; James, Nicholas D; Maughan, Timothy; Paton, Nicholas; Royston, Patrick J

    2017-10-01

    There is real need to change how we do some of our clinical trials, as currently the testing and development process is too slow, too costly and too failure-prone often we find that a new treatment is no better than the current standard. Much of the focus on the development and testing pathway has been in improving the design of phase I and II trials. In this article, we present examples of new methods for improving the design of phase III trials (and the necessary lead up to them) as they are the most time-consuming and expensive part of the pathway. Key to all these methods is the aim to test many treatments and/or pose many therapeutic questions within one protocol.

  3. Fecal Collection and Stabilization Methods for Improved Fecal DNA Test for Colorectal Cancer in a Screening Setting

    Directory of Open Access Journals (Sweden)

    Francesca Maria Carozzi

    2013-01-01

    Full Text Available Early detection of CRC and adenomas reduces CRC-related mortality. The optimal screening test for CRC is still a subject of debate, and molecular stool sample analysis could provide a valid alternative to conventional methods in terms of compliance and practicability. Seven fecal DNA storage systems were evaluated in two successive phases. In the first phase of the study was selected the preservative buffer able to ensure the best human DNA recovery. In the second phase was evaluated human DNA stability, amplificability and integrity in DNA extracted from selected buffer. Results showed that the best performance was obtained in samples stored in 100 mM EDTA buffer and Genefec buffer. Likewise buffer addition yielded a significant increase in DNA stability and integrity without PCR inhibition, compared to the matched aliquots with no buffer added. Our study shows that samples collected in stabilization solution stabilize DNA so that intact nucleic acids, are more effectively detectable in the molecular assay. DNA buffer preservation and storage conditions could be useful to guarantee the most consistent yield in human DNA. Stabilization buffer addition to stool samples prior to transport presents an easily implemented solution that appears to be highly effective. Overall DNA extracted from faeces preserved in preservative buffer can feasibility been used for molecular analysis leading to an increase of assay sensitivity.

  4. Development and Usability Testing of a Computer-Tailored Decision Support Tool for Lung Cancer Screening: Study Protocol.

    Science.gov (United States)

    Carter-Harris, Lisa; Comer, Robert Skipworth; Goyal, Anurag; Vode, Emilee Christine; Hanna, Nasser; Ceppa, DuyKhanh; Rawl, Susan M

    2017-11-16

    follow-up survey. We expect to have results by December 31, 2017 and to have data analysis completed by March 1, 2018. Results from usability testing indicate that the computer-tailored decision support tool is easy to use, is helpful, and provides a satisfactory experience for the user. At the conclusion of phase III (pilot RCT), we will have preliminary effect sizes to inform a future fully powered RCT on changes in (1) knowledge about lung cancer and screening, (2) perceived risk of lung cancer, (3) perceived benefits of lung cancer screening, (4) perceived barriers to lung cancer screening, (5) self-efficacy for lung cancer screening, and (6) perceptions of being adequately prepared to engage in a discussion with their clinician about lung cancer screening. ©Lisa Carter-Harris, Robert Skipworth Comer, Anurag Goyal, Emilee Christine Vode, Nasser Hanna, DuyKhanh Ceppa, Susan M Rawl. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 16.11.2017.

  5. Reference markers in computer aided orthopaedic surgery: rotational stability testings and clinical implications.

    Science.gov (United States)

    Kendoff, Daniel; Gardner, Michael J; Krettek, Christian; Hüfner, Tobias; Citak, Musa

    2008-06-01

    Navigation procedures rely on the stability of the reference arrays (RA) fixed to the bony anatomy. The risk of inadvertent collision and unnoticed movements of the RA may occur, and limb movements might also provocate collisions. Consequently, relevant measurements failures during the navigated procedure might occur and reduce the overall precision of the system. The magnitude of torque to destabilize an RA from its bony-fixation is unknown. The purpose of this study was to determine the ability of standard RA's to resist applied torque. A digital torque application device was developed to allow for precise torque application to the RA system at four cadavers. Clockwise, gradually increasing rotational force was applied to the RA in 1, 2, or 3 Nm, held for 1 s and released, repeated in 10 cycles. One pin fixation systems with 4.0 Schanz pins were used. A second RA was fixed 20 cm proximal to the tested RA. A navigation system was used to measure the relative positions of both RA's during torque application. The rotational differences at torque application were calculated and statistically evaluated. Results revealed averaged 1.0 degrees rotation [range (r), 1.0-1.1 degrees ] with first cycle of 1 Nm torque, the last cycle averaged 1.0 degrees (r, 1.0-1.1 degrees ) with no significant differences in rotation between any of the cycles (p > 0.5). Torque of 2 Nm resulted in 1.8 degrees rotation (r, 1.5-1.8 degrees ) with no significant increases between first and second cycle (p = 0.56), second and third trials (p = 0.35) while fourth cycle averaged 2.0 degrees , with significant increase (p = 0.011). All subsequent cycles resulted in significant increases. Torque of 3 Nm produced 2.9 degrees of rotation for initial cycle (r,2.5-3.3 degrees ), with significant increases with each cycle (p or =2 Nm may cause loosening of the RA, thus may lose its original position relative to the bone. Surgeons using computer aided surgery systems should be aware of possible

  6. Testing and improving the redox stability of Ni-based solid oxide fuel cells

    DEFF Research Database (Denmark)

    Pihlatie, Mikko; Ramos, Tania; Kaiser, Andreas

    2009-01-01

    cells. When the symmetric cells are reduced and redox cycled isothermally at 850 °C, no major change in the serial or polarisation resistance of the cell and electrodes was measured. When the cells are, after the similar initial reduction treatment, redox cycled at 650 °C, the serial resistance remains......Despite active development, solid oxide fuel cells (SOFCs) based on Ni-YSZ anodes still suffer from thermomechanical instability under conditions where the anode side is exposed to oxidising conditions at high temperature. In the first part of the paper, structures and solutions, which could...... improve the redox stability of Ni-YSZ anode supported SOFC's in terms of dimensional and mechanical stability are reported. Porosity is identified as a major microstructural parameter linked to the dimensional and structural stability during redox cycling. The cumulative redox strain (CRS) after three...

  7. California Bearing Ratio (CBR) test on stabilization of clay with lime addition

    Science.gov (United States)

    Hastuty, I. P.; Roesyanto; Limbong, M. N.; Oberlyn, S. J.

    2018-02-01

    Clay is a type of soil with particles of certain minerals giving plastic properties when mixed with water. Soil has an important role in a construction, besides as a building material in a wide variety of civil engineering works, soil is also used as supporting foundation of the building. Basic properties of clay are rock-solid in dry and plastic with medium water content. In high water content, clay becomes sticky like (cohesive) and soften. Therefore, clay stabilization is necessary to repair soil’s mechanical properties. In this research, lime is use as a stabilizer that contains the Ca+ element to bond bigger particles. Lime used is slaked lime Ca(OH)2. Clay used has liquid limitation (LL) value of 47.33%, plasticity index of 29.88% and CBR value 6.29. The results explain about 10% lime mixture variation gives the optimum stabilized clay with CBR value of 8.75%.

  8. Stabilization of the Beam Intensity in the Linac at the CTF3 CLIC Test Facility

    CERN Document Server

    Dubrovskiy, A; Bathe, BN; Srivastava, S

    2013-01-01

    A new electron beam stabilization system has been introduced in CTF3 in order to open new possibilities for CLIC beam studies in ultra-stable conditions and to provide a sustainable tool to keep the beam intensity and energy at its reference values for long term operations. The stabilization system is based on a pulse-to-pulse feedback control of the electron gun to compensate intensity deviations measured at the end of the injector and at the beginning of the linac. Thereby it introduces negligible beam distortions at the end of the linac and it significantly reduces energy deviations. A self-calibration mechanism has been developed to automatically configure the feedback controller for the optimum performance. The residual intensity jitter of 0.045% of the stabilized beam was measured whereas the CLIC requirement is 0.075%.

  9. Stabilization of inorganic mixed waste to pass the TCLP and STLC tests using clay and pH-insensitive additives

    International Nuclear Information System (INIS)

    Bowers, J.S.; Anson, J.R.; Painter, S.M.; Maitino, R.E.

    1995-03-01

    Stabilization traps toxic contaminants (usually both chemically and physically) in a matrix so that they do not leach into the environment. Typical contaminants are metals (mostly transition metals) that exhibit the characteristic of toxicity. The stabilization process routinely uses pozzolanic materials. Portland cement, fly ash-lime mixes, gypsum cements, and clays are some of the most common materials. In many instances, materials that can pass the Toxicity Characteristic Leaching Procedure (TCLP-the federal leach test) or the Soluble Threshold Leachate Concentration (STLC-the California leach test) must have high concentrations of lime or other caustic material because of the low pH of the leaching media. Both leaching media, California's and EPA's, have a pH of 5.0. California uses citric acid and sodium citrate while EPA uses acetic acid and sodium acetate. These media can form ligands that provide excellent metal leaching. Because of the aggressive nature of the leaching medium, stabilized wastes in many cases will not pass the leaching tests. At the Lawrence Livermore National Laboratory, additives such as dithiocarbamates and thiocarbonates, which are pH-insensitive and provide resistance to ligand formation, are used in the waste stabilization process. Attapulgite, montmorillonite, and sepiolite clays are used because they are forgiving (recipe can be adjusted before the matrix hardens). The most frequently used stabilization process consists of a customized recipe involving waste sludge, clay and dithiocarbamate salt, mixed with a double planetary mixer into a pasty consistency. TCLP and STLC data on this waste matrix have shown that the process matrix meets land disposal requirements

  10. Identification of the period of stability in a balance test after stepping up using a simplified cumulative sum.

    Science.gov (United States)

    Safieddine, Doha; Chkeir, Aly; Herlem, Cyrille; Bera, Delphine; Collart, Michèle; Novella, Jean-Luc; Dramé, Moustapha; Hewson, David J; Duchêne, Jacques

    2017-11-01

    Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static. In the present study, a method is presented to detect the stabilization period after a subject has stepped onto the BQT. Four different phases of the test are identified (stepping-on, stabilization, balancing, stepping-off), ensuring that subjects are static when parameters from the balancing phase are calculated. The method, based on a simplified cumulative sum (CUSUM) algorithm, could detect the change between unstable and stable stance. The time taken to stabilize significantly affected the static balance variables of surface area and trajectory velocity, and was also related to Timed-up-and-Go performance. Such a finding suggests that the time to stabilize could be a worthwhile parameter to explore as a potential indicator of balance problems and fall risk in older people. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

  11. Analysis of cerium-composite polymer-electrolyte membranes during and after accelerated oxidative-stability test

    Science.gov (United States)

    Shin, Dongwon; Han, Myungseong; Shul, Yong-Gun; Lee, Hyejin; Bae, Byungchan

    2018-02-01

    The oxidative stability of membranes constructed from a composite of pristine sulfonated poly(arylene ether sulfone) and cerium was investigated by conducting an accelerated oxidative-stability test at the open-circuit voltage (OCV). The membranes were analyzed in situ through OCV and impedance measurements, cyclic voltammetry, and linear-sweep voltammetry to monitor the electrochemical properties during the stability test. Although the high-frequency resistance of a composite membrane was slightly higher than that of a pristine membrane because of the exchange of protons from the sulfonic acid with cerium ions, the composite membrane maintained its potential for much longer than the pristine membrane. The effect of the cerium ions as radical scavengers was confirmed by analyzing the drain water and chemical structure after operation. These post-operation analyses confirmed that cerium ions improved the oxidative stability of the hydrocarbon-based polymer during fuel-cell operation. It is clear that the cerium-based radical scavengers prevented chemical degradation of the polymer membrane as well as the electrode in terms of hydrogen cross-over, polymer-chain scission, and the electrochemical surface area, while they rarely diffused outward from the membrane.

  12. A statistical test of the stability assumption inherent in empirical estimates of economic depreciation.

    Science.gov (United States)

    Shriver, K A

    1986-01-01

    Realistic estimates of economic depreciation are required for analyses of tax policy, economic growth and production, and national income and wealth. THe purpose of this paper is to examine the stability assumption underlying the econometric derivation of empirical estimates of economic depreciation for industrial machinery and and equipment. The results suggest that a reasonable stability of economic depreciation rates of decline may exist over time. Thus, the assumption of a constant rate of economic depreciation may be a reasonable approximation for further empirical economic analyses.

  13. Technical justifications for the tests and criteria in the waste form technical position appendix on cement stabilization

    International Nuclear Information System (INIS)

    Siskind, B.; Cowgill, M.G.

    1992-01-01

    As part of its technical assistance to the Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a background document for the cement stabilization appendix, Appendix A, to Rev. 1 of the Technical Position on Waste Form (TP). Here we present an overview of this background document, which provides technical justification for the stability tests to be performed on cement-stabilized waste forms and for the criteria posed in each test, especially for those tests which have been changed from their counterparts in the May 1983 Rev. 0 TP. We address guidelines for procedures from Appendix A which are considered in less detail or not at all in the Rev. 0 of the TP, namely, qualification specimen preparation (mixing, curing, storage), statistical sampling and analysis, process control program specimen preparation and examination, and surveillance specimens. For each waste form qualification test, criterion or procedural guidelines, we consider the reason for its inclusion in Appendix A, the changes from Rev. 0 of the TP (if applicable), and a discussion of the justification or rationale for these changes

  14. Development and Testing of a Literature Search Protocol for Evidence Based Nursing: An Applied Student Learning Experience

    Directory of Open Access Journals (Sweden)

    Andy Hickner

    2011-09-01

    Full Text Available Objective – The study aimed to develop a search protocol and evaluate reviewers' satisfaction with an evidence-based practice (EBP review by embedding a library science student in the process.Methods – The student was embedded in one of four review teams overseen by a professional organization for oncology nurses (ONS. A literature search protocol was developed by the student following discussion and feedback from the review team. Organization staff provided process feedback. Reviewers from both case and control groups completed a questionnaire to assess satisfaction with the literature search phases of the review process. Results – A protocol was developed and refined for use by future review teams. The collaboration and the resulting search protocol were beneficial for both the student and the review team members. The questionnaire results did not yield statistically significant differences regarding satisfaction with the search process between case and control groups. Conclusions – Evidence-based reviewers' satisfaction with the literature searching process depends on multiple factors and it was not clear that embedding an LIS specialist in the review team improved satisfaction with the process. Future research with more respondents may elucidate specific factors that may impact reviewers' assessment.

  15. Combustion Stability of the Gas Generator Assembly from J-2X Engine E10001 and Powerpack Tests

    Science.gov (United States)

    Hulka, J. R.; Kenny, R. L.; Casiano, M. J.

    2013-01-01

    Testing of a powerpack configuration (turbomachinery and gas generator assembly) and the first complete engine system of the liquid oxygen/liquid hydrogen propellant J-2X rocket engine have been completed at the NASA Stennis Space Center. The combustion stability characteristics of the gas generator assemblies on these two systems are of interest for reporting since considerable effort was expended to eliminate combustion instability during early development of the gas generator assembly with workhorse hardware. Comparing the final workhorse gas generator assembly development test data to the powerpack and engine system test data provides an opportunity to investigate how the nearly identical configurations of gas generator assemblies operate with two very different propellant supply systems one the autonomous pressure-fed test configuration on the workhorse development test stand, the other the pump-fed configurations on the powerpack and engine systems. The development of the gas generator assembly and the elimination of the combustion instability on the pressure-fed workhorse test stand have been reported extensively in the two previous Liquid Propulsion Subcommittee meetings 1-7. The powerpack and engine system testing have been conducted from mid-2011 through 2012. All tests of the powerpack and engine system gas generator systems to date have been stable. However, measureable dynamic behavior, similar to that observed on the pressure-fed test stand and reported in Ref. [6] and attributed to an injection-coupled response, has appeared in both powerpack and engine system tests. As discussed in Ref. [6], these injection-coupled responses are influenced by the interaction of the combustion chamber with a branch pipe in the hot gas duct that supplies gaseous helium to pre-spin the turbine during the start transient. This paper presents the powerpack and engine system gas generator test data, compares these data to the development test data, and provides additional

  16. Diversity of non-acarine arachnids of the Ophathe Game Reserve, South Africa: Testing a rapid sampling protocol

    Directory of Open Access Journals (Sweden)

    Charles R. Haddad

    2015-07-01

    Full Text Available As part of the second phase of the South African National Survey of Arachnida (SANSA, field surveys were conducted in many degree-square grids throughout the country using a standardised rapid sampling protocol. This study reports on the arachnid diversity of the Ophathe Game Reserve (OGR in northern KwaZulu-Natal, as found during a preliminary survey in June 2007 (mid winter and a SANSA field survey in October 2008 (mid spring in four representative habitats. The SANSA survey included seven sampling methods: pitfalls, beating, sweep-netting, litter sifting, hand collecting, night collecting and Winkler traps. A total of 282 species in six arachnid orders were collected during the two surveys, of which spiders were the most species-rich order (268 species in 47 families. The SANSA survey yielded 966 adult arachnids, representing six orders and 197 species, with a further 67 species represented only by immatures. Although adult arachnid abundance (n differed considerably between the four habitats (range: 156–321, adult species richness (Sobs was less variable (range: 65–85. These survey results are comparable with several longer-term surveys in the Savanna biome, and indicate that the SANSA sampling protocol can yield an impressive diversity of arachnids during a relatively short period of sampling, with a high level of coverage (> 0.8 for sites and most sampling methods and moderate levels of sample completion for adults (> 0.55 for all sites, despite logistical and temporal challenges. Additional repetitions of the SANSA sampling protocol in other seasons will likely increase biodiversity knowledge of arachnids in OGR considerably. Conservation implications: The implementation of rapid sampling protocols in an atlas project is essential to generate a large volume of species-level data. The SANSA protocol is an efficient means for rapidly generating arachnid data, and in future will allow for an assessment of diversity patterns in degree

  17. Full-Scale Accelerated Testing of Multi-axial Geogrid Stabilized Flexible Pavements

    Science.gov (United States)

    2017-06-01

    axial geogrid in a flexible pavement base course provides a significant structural benefit. ERDC/GSL TR-17-9 39 References American Society for...Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Final...Effective stabilized layer structural coefficient. ...................................................................... 37 ERDC/GSL TR-17-9 vii

  18. Hydrolytic stability of polycarbonate-based polyurethane elastomers tested in physiologically simulated conditions

    Czech Academy of Sciences Publication Activity Database

    Serkis, Magdalena; Špírková, Milena; Poreba, Rafal; Hodan, Jiří; Kredatusová, Jana; Kubies, Dana

    2015-01-01

    Roč. 119, September (2015), s. 23-34 ISSN 0141-3910 R&D Projects: GA ČR(CZ) GA13-06700S Institutional support: RVO:61389013 Keywords : polyurethane * elastomer * hydrolytic stability Subject RIV: CD - Macromolecular Chemistry Impact factor: 3.120, year: 2015

  19. 16 CFR 1203.15 - Positional stability test (roll-off resistance).

    Science.gov (United States)

    2010-01-01

    ... SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.15 Positional stability... the retention system in accordance with the manufacturer's instructions. Adjust the straps to remove any slack. (3) Suspend the dynamic impact system from the helmet by positioning the flexible strap...

  20. Evaluation of the ability of rod drop tests to verify the stability margins in FTR

    International Nuclear Information System (INIS)

    Harris, R.A.; Sevenich, R.A.

    1976-01-01

    Predictions of the stability characteristics of FTR indicate that the reactor can be easily controlled even under the worst possible conditions. Nevertheless, experimental verification and monitoring of these characteristics will be performed during operation of the reactor. An initial evaluation of rod drop experiments which could possibly provide this verification is presented

  1. Mechanical characterization and optoelectronic measurement of parietal bone thickness before and after monocortical bone graft harvest: design and validation of a test protocol.

    Science.gov (United States)

    Laure, Boris; Geais, Laurent; Tranquart, François; Goga, Dominique

    2011-01-01

    Parietal bone grafts are commonly used in craniomaxillofacial surgery. However, bone removal may weaken the parietal bone and lead to deleterious complications. The aim of our study was to design a test protocol for characterization of the impact resistance of parietal bone before and after monocortical bone graft harvest and to validate an optoelectronic measurement of parietal bone thickness. Twelve fresh human cadaver heads were used for the validation study. To evaluate impact resistance, we developed a pendulum Charpy impact testing machine. The impact force was gradually increased until failure (fracture) of the defined parietal bone area. According to the protocol, we measured the maximum absorbable energy or impact force to failure. With our test setup, measurement of the impact resistance of parietal bone was accurate to within 0.025 J. We defined a range of values and particularly a threshold value. The initial maximal impact must not to exceed 4 J. For more accuracy, we compared 5 nondestructive measurement methods using a surgical navigation system with optoelectronic tracking. We achieved an algorithm based on 2 methods that ensured a measurement resolution of 0.1 mm. Validation of this protocol will allow us to evaluate the loss of strength resulting from bone removal and the correlation between strength and thickness of the parietal bone.

  2. Design, ancillary testing, analysis and fabrication data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Aniversario, R. B.; Harvey, S. T.; Mccarty, J. E.; Parsons, J. T.; Peterson, D. C.; Pritchett, L. D.; Wilson, D. R.; Wogulis, E. R.

    1983-01-01

    The horizontal stabilizer of the 737 transport was redesigned. Five shipsets were fabricated using composite materials. Weight reduction greater than the 20% goal was achieved. Parts and assemblies were readily produced on production-type tooling. Quality assurance methods were demonstrated. Repair methods were developed and demonstrated. Strength and stiffness analytical methods were substantiated by comparison with test results. Cost data was accumulated in a semiproduction environment. FAA certification was obtained.

  3. Tests of US rock salt for long-term stability of CAES reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Gehle, R.M.; Thoms, R.L.

    1986-01-01

    This is a report on laboratory tests to assess the effects of compressed air energy storage (CAES) on rock salt within the US. The project included a conventional laboratory test phase, with triaxial test machines, and a bench-scale test phase performed in salt mines in southern Louisiana. Limited numerical modeling also was performed to serve as a guide in selecting test layouts and for interpreting test data.

  4. Prospective analysis of stability testing for bone-anchored hearing implants in children after osseointegrating surgery without skin thinning.

    Science.gov (United States)

    Hultcrantz, Malou; Lanis, Aviya

    2015-04-01

    To report normative values for osseointegration in 10 children with bone-anchored hearing implants who were consecutively operated on using a tissue preserving technique with individualized abutments and prospectively followed with stability testing 1 year after surgery. Children were implanted with bone-anchored hearing devices using a non-skin thinning implantation technique and followed during the course of a year. Mean age was 5.1 years. Stability testing with Osstell's resonance frequency analysis (RFA) measurement was used at each visit, providing values between 0 and 100 (representing a range of low to high stability, respectively). Clinical signs and symptoms were also noted at each visit. Three of the children were operated on using a two-step procedure, while the remaining seven children were operated on using a one-step procedure. Eight of the children showed skin-related problems during the 1-year control period that were easily treated. Two children experienced an abutment loss early following surgery (1 two-step and 1 one-step) and showed low resonance measurements of 30 or less within the first 3-4 weeks. Two children experienced a traumatic abutment loss and two required a change in abutment length. During the 1-year follow-up, nine children demonstrated signs of peri-implant infections, only two of which were recurrent. Stability was measured to be higher in eight children with longer abutments. Two children experienced low stability (hearing aid and mean ISQ values were 56.2 and 47.5 for 6mm and 9mm abutments, respectively. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  5. Calf-raise senior: a new test for assessment of plantar flexor muscle strength in older adults: protocol, validity, and reliability.

    Science.gov (United States)

    André, Helô-Isa; Carnide, Filomena; Borja, Edgar; Ramalho, Fátima; Santos-Rocha, Rita; Veloso, António P

    2016-01-01

    This study aimed to develop a new field test protocol with a standardized measurement of strength and power in plantar flexor muscles targeted to functionally independent older adults, the calf-raise senior (CRS) test, and also evaluate its reliability and validity. Forty-one subjects aged 65 years and older of both sexes participated in five different cross-sectional studies: 1) pilot (n=12); 2) inter- and intrarater agreement (n=12); 3) construct (n=41); 4) criterion validity (n=33); and 5) test-retest reliability (n=41). Different motion parameters were compared in order to define a specifically designed protocol for seniors. Two raters evaluated each participant twice, and the results of the same individual were compared between raters and participants to assess the interrater and intrarater agreement. The validity and reliability studies involved three testing sessions that lasted 2 weeks, including a battery of functional fitness tests, CRS test in two occasions, accelerometry, and strength assessments in an isokinetic dynamometer. The CRS test presented an excellent test-retest reliability (intraclass correlation coefficient [ICC] =0.90, standard error of measurement =2.0) and interrater reliability (ICC =0.93-0.96), as well as a good intrarater agreement (ICC =0.79-0.84). Participants with better results in the CRS test were younger and presented higher levels of physical activity and functional fitness. A significant association between test results and all strength parameters (isometric, r =0.87, r 2 =0.75; isokinetic, r =0.86, r 2 =0.74; and rate of force development, r =0.77, r 2 =0.59) was shown. This study was successful in demonstrating that the CRS test can meet the scientific criteria of validity and reliability. The test can be a good indicator of ankle strength in older adults and proved to discriminate significantly between individuals with improved functionality and levels of physical activity.

  6. A Novel Amphibian Tier 2 Testing Protocol: A 30-Week Exposure of Xenopus Tropicalis to the Antiandrogen Flutamide

    National Research Council Canada - National Science Library

    Knechtges, Paul L; Sprando, Robert L; Porter, Karen L; Brennan, Linda M; Miller, Mark F; Kumsher, David M; Dennis, William E; Brown, Charles C; Clegg Paul L. Knechtges. Robert L. Sprando. Karen L. Potter., Eric D

    2007-01-01

    ...) using validated test systems. Subsequently, the Endocrine Disruptor Screening and Testing Advisory Committee recommended the development of a standardized amphibian assay for tier 2 testing of EDCs...

  7. Design of a Channel Error Simulator using Virtual Instrument Techniques for the Initial Testing of TCP/IP and SCPS Protocols

    Science.gov (United States)

    Horan, Stephen; Wang, Ru-Hai

    1999-01-01

    There exists a need for designers and developers to have a method to conveniently test a variety of communications parameters for an overall system design. This is no different when testing network protocols as when testing modulation formats. In this report, we discuss a means of providing a networking test device specifically designed to be used for space communications. This test device is a PC-based Virtual Instrument (VI) programmed using the LabVIEW(TM) version 5 software suite developed by National Instruments(TM)TM. This instrument was designed to be portable and usable by others without special, additional equipment. The programming was designed to replicate a VME-based hardware module developed earlier at New Mexico State University (NMSU) and to provide expanded capabilities exceeding the baseline configuration existing in that module. This report describes the design goals for the VI module in the next section and follows that with a description of the design of the VI instrument. This is followed with a description of the validation tests run on the VI. An application of the error-generating VI to networking protocols is then given.

  8. Bioremediation protocols

    National Research Council Canada - National Science Library

    Sheehan, David

    1997-01-01

    ..., .. . . . . .. ,. . . .. . . . . . . . .. . . . . .. . . .. . .. 3 2 Granular Nina Sludge Christiansen, Consortia lndra for Bioremediation, M. Mathrani, and Birgitte K. Ahring . 23 PART II PROTOCOLS...

  9. Temporal stability of the Francis Scale of Attitude toward Christianity short-form: test-retest data over one week.

    Science.gov (United States)

    Lewis, Christopher Alan; Cruise, Sharon Mary; McGuckin, Conor

    2005-04-01

    This study evaluated the test-retest reliability of the Francis Scale of Attitude toward Christianity short-form. 39 Northern Irish undergraduate students completed the measure on two occasions separated by one week. Stability across the two administrations was high, r = .92, and there was no significant change between Time 1(M = 25.2, SD = 5.4) and Time 2 (M = 25.7, SD = 6.2). These data support the short-term test-retest reliability of the Francis Scale of Attitude toward Christianity short-form.

  10. The Test of Terrain: The Impact of Stability Operations Upon the Armed Forces

    Science.gov (United States)

    2005-06-01

    exercise of initiative and imagination, a fact not always welcomed by the establishment after operations cease. * Despite general European public " shyness ...Studies Institute co-hosted a conference on "The Impact of Stability Operations Upon the Armed Forces" in cooperation with the Centre d’Etudes en...the belated environment, "lessons" need to be " learned " and recognition that what was first seen as cowardice implanted in the deployed force rapidly

  11. The intracarotid amobarbital procedure (Wada test with two protocols combined, Montreal and Seattle Procedimentos do amobarbital intracarotideo (teste de Wada com dois protocolos combinados, Montreal e Seattle

    Directory of Open Access Journals (Sweden)

    Paulo J. M. Leite

    1997-06-01

    Full Text Available The intracarotid amobarbital procedure was carried out in 8 male and 7 female candidates to temporal lobectomy, and a female candidate to frontal lesionectomy, aged 18-50 (mean 32.5 years. Language and memory were tested after injection in each hemisphere. Both were measured by the Montreal procedure. In 9 patients language and memory were evaluated with the Seattle procedure too. In 12 patients the left hemisphere was dominant for language; three had bilateral dominance. In I patient the Seattle procedure demonstrated the dominant hemisphere by relatively slowness of speech during the drug effect in the left hemisphere. Memory was defined to be in the left hemisphere in 12 patients, in the right in 2, bilateral in 1 and in another lateralization was not possible. In 1 patient memory dominance was determined by the Montreal protocol alone because of lack of cooperation. These early results indicate that the methods may be complementary for determination of language and memory dominance in epilepsy surgery candidates.O testo do amobarbital intracarotídeo foi realizado em 8 homens e 7 mulheres candidatos a lobectomia temporal e em uma mulher candidata a lesionectomia frontal, com idades de 18-50 (média 32,5 anos. Linguagem e memória foram testadas após a injeção do amobarbial em cada hemisfério cerebral. Todos os pacientes foram avaliados pelo método de Montreal e 9 também pelo método de Seattle. Em 12 pacientes o hemisfério cerebral esquerdo foi dominante para linguagem e em 3 pacientes houve dominância bilateral. Em uma paciente a linguagem foi determinada apenas através do método de Seattle, com lentificação relativa da fal a, sob ação da droga no hemisfério cerebral esquerdo. Dominância da memória à esquerda foi observada em 12 pacientes, à direita em 2, bilateral em 1 e em outro não foi lateralizada. Dominância da memória foi definida apenas através do método de Montreal em um paciente, devido à pouca coopera

  12. Dose evaluation using multiple-aliquot quartz OSL: Test of methods and a new protocol for improved accuracy and precision

    DEFF Research Database (Denmark)

    Jain, M.; Bøtter-Jensen, L.; Singhvi, A.K.

    2003-01-01

    Multiple-aliquot quartz OSL dose-response curves often suffer from substantial variability in the luminescence output from identically treated aliquots (scatter) that leads to large uncertainties in the equivalent-dose estimates. In this study, normalisation and its bearing on the accuracy...... from the single-aliquot-regeneration protocol (SAR) gave similar accuracy and precision, (C) 2002 Elsevier Science Ltd. All rights reserved....

  13. Quality assessment in in vivo NMR spectroscopy: V. Multicentre evaluation of prototype test objects and protocols for performance assessment in small bore MRS equipment

    DEFF Research Database (Denmark)

    Howe, F.A.; Canese, R; Podo, F

    1995-01-01

    using ISIS as volume localization sequence in 31P MRS. The results suggested the interest of adopting some of these prototypes for improving the comparison of spectroscopy data obtained from different sites, for providing useful means of quality assurance in experimental MRS, and facilitating......This paper reports the results of multicentre studies aimed at designing, constructing, and evaluating prototype test objects for performance assessment in small-bore MRS systems, by utilizing the test protocols already proposed by the EEC COMAC-BME Concerted Action for clinical MRS equipment...

  14. Best Practices and Testing Protocols for Benchmarking ORR Activities of Fuel Cell Electrocatalysts Using Rotating Disk Electrode

    Energy Technology Data Exchange (ETDEWEB)

    Kocha, Shyam S.; Shinozaki, Kazuma; Zack, Jason W.; Myers, Deborah J.; Kariuki, Nancy N.; Nowicki, Tammi; Stamenkovic, Vojislav; Kang, Yijin; Li, Dongguo; Papageorgopoulos, Dimitrios

    2017-05-02

    Abstract Thin-film-rotating disk electrodes (TF-RDEs) are the half-cell electrochemical system of choice for rapid screening of oxygen reduction reaction (ORR) activity of novel Pt supported on carbon black supports (Pt/C) electrocatalysts. It has been shown that the magnitude of the measured ORR activity and reproducibility are highly dependent on the system cleanliness, evaluation protocols, and operating conditions as well as ink formulation, composition, film drying, and the resultant film thickness and uniformity. Accurate benchmarks of baseline Pt/C catalysts evaluated using standardized protocols and best practices are necessary to expedite ultra-low-platinum group metal (PGM) catalyst development that is crucial for the imminent commercialization of fuel cell vehicles. We report results of evaluation in three independent laboratories of Pt/C electrocatalysts provided by commercial fuel cell catalyst manufacturers (Johnson Matthey, Umicore, Tanaka Kikinzoku Kogyo—TKK). The studies were conducted using identical evaluation protocols/ink formulation/film fabrication albeit employing unique electrochemical cell designs specific to each laboratory. The ORR activities reported in this work provide a baseline and criteria for selection and scale-up of novel high activity ORR electrocatalysts for implementation in proton exchange membrane fuel cells (PEMFCs).

  15. Collegiate Student Athletes With History of ADHD or Academic Difficulties Are More Likely to Produce an Invalid Protocol on Baseline ImPACT Testing.

    Science.gov (United States)

    Manderino, Lisa; Gunstad, John

    2018-03-01

    Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions. Cross-sectional study. Midsized public university. Nine hundred forty-nine National College Athletic Association athletes (average age = 19.2 years; 6.8% ADHD, 5.6% Academic Difficulties, 2.0% comorbid ADHD/Academic Difficulties). Three seasons of baseline ImPACT protocols were analyzed. Student athletes were grouped using self-reported histories of ADHD or academic difficulties taken from ImPACT demographic questions. ImPACT composite scores and protocol validity. Student athletes in the academic difficulties and comorbid groups performed worse on ImPACT composite scores (Pillai's Trace = 0.05), though this pattern did not emerge for those with ADHD. Student athletes with comorbid history were more likely to produce an invalid baseline (10.5% invalid) (χ (2) = 11.08, P = 0.004). Those with ADHD were also more likely to produce an invalid protocol (7.7% invalid, compared with 2.6% in student athletes with no history) (χ (2) = 10.70, P = 0.005). These findings suggest that student athletes reporting comorbid histories or histories of academic difficulties alone produce lower ImPACT composite scores, and that those with comorbid histories or histories of ADHD alone produce invalid protocol warnings more frequently than student athletes without such histories. Future studies should further examine invalid score thresholds on the ImPACT, especially in student

  16. Forest, Trees, Dynamics: Results from a novel Wisconsin Card Sorting Test variant Protocol for Studying Global-Local Attention and Complex Cognitive Processes

    Directory of Open Access Journals (Sweden)

    Benjamin eCowley

    2016-02-01

    Full Text Available BackgroundRecognition of objects and their context relies heavily on the integrated functioning of global and local visual processing. In a realistic setting such as work, this processing becomes a sustained activity, implying a consequent interaction with executive functions.MotivationThere have been many studies of either global-local attention or executive functions; however it is relatively novel to combine these processes to study a more ecological form of attention. We aim to explore the phenomenon of global-local processing during a task requiring sustained attention and working memory.MethodsWe develop and test a novel protocol for global-local dissociation, with task structure including phases of divided ('rule search' and selective ('rule found' attention, based on the Wisconsin Card Sorting Task.We test it in a laboratory study with 25 participants, and report on behaviour measures (physiological data was also gathered, but not reported here. We develop novel stimuli with more naturalistic levels of information and noise, based primarily on face photographs, with consequently more ecological validity.ResultsWe report behavioural results indicating that sustained difficulty when participants test their hypotheses impacts matching-task performance, and diminishes the global precedence effect. Results also show a dissociation between subjectively experienced difficulty and objective dimension of performance, and establish the internal validity of the protocol.ContributionWe contribute an advance in the state of the art for testing global-local attention processes in concert with complex cognition. With three results we establish a connection between global-local dissociation and aspects of complex cognition. Our protocol also improves ecological validity and opens options for testing additional interactions in future work.

  17. Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves.

    Science.gov (United States)

    Sierad, Leslie Neil; Simionescu, Agneta; Albers, Christopher; Chen, Joseph; Maivelett, Jordan; Tedder, Mary Elizabeth; Liao, Jun; Simionescu, Dan T

    2010-06-01

    Heart valve tissue engineering requires biocompatible and hemocompatible scaffolds that undergo remodeling and repopulation, but that also withstand harsh mechanical forces immediately following implantation. We hypothesized that reversibly stabilized acellular porcine valves, seeded with endothelial cells and conditioned in pulsatile bioreactors would pave the way for next generations of tissue engineered heart valves (TEHVs). A novel valve conditioning system was first designed, manufactured and tested to adequately assess TEHVs. The bioreactor created proper closing and opening of valves and allowed for multiple mounting methods in sterile conditions. Porcine aortic heart valve roots were decellularized by chemical extractions and treated with penta-galloyl glucose (PGG) for stabilization. Properties of the novel scaffolds were evaluated by testing resistance to collagenase and elastase, biaxial mechanical analysis, and thermal denaturation profiles. Porcine aortic endothelial cells were seeded onto the leaflets and whole aortic roots were mounted within the dynamic pulsatile heart valve bioreactor system under physiologic pulmonary valve pressures and analyzed after 17 days for cell viability, morphology, and metabolic activity. Our tissue preparation methods effectively removed cells, including the potent α-Gal antigen, while leaving a well preserved extra-cellular matrix scaffold with adequate mechanical properties. PGG enhanced stabilization of extracellular matrix components but also showed the ability to be reversible. Engineered valve scaffolds encouraged attachment and survival of endothelial cells for extended periods and showed signs of widespread cell coverage after conditioning. Our novel approach shows promise toward development of sturdy and durable TEHVs capable of remodeling and cellular repopulation.

  18. A protocol for patients with cardiovascular implantable devices undergoing magnetic resonance imaging (MRI): should defibrillation threshold testing be performed post-(MRI).

    Science.gov (United States)

    Burke, Peter Thomas; Ghanbari, Hamid; Alexander, Patrick B; Shaw, Michael K; Daccarett, Marcos; Machado, Christian

    2010-06-01

    Magnetic resonance imaging (MRI) in patients with Cardiovascular Implantable Electronic Devices (CIED) has not been approved by the Food and Drug Administration. Recent data suggests MRI as a relative rather than absolute contraindication in CIED patients. Recently, the American Heart Association has recommended defibrillation threshold testing (DFTT) in implantable cardioverter defibrillator (ICD) patients undergoing MRI. We evaluated the feasibility and safety of a protocol for MRI in CIED patients, incorporating the new recommendations on DFTT. Consecutive patients with CIED undergoing MRI were included. The protocol consisted of continuous monitoring during imaging, device interrogation pre- and post-MRI, reprogramming of the pacemaker to an asynchronous mode in pacemaker-dependent (PMD) patients and a non-tracking/sensing mode for non-PMD patients. All tachyarrhythmia therapies were disabled. Devices were interrogated for lead impedance, battery life, pacing, and sensing thresholds. All patients with ICD underwent DFTT/defibrillator safety margin testing (DSMT) post-MRI. A total of 92 MRI's at 1.5 Tesla were performed in 38 patients. A total of 13 PMD patients, ten ICD patients, four cardiac resynchronization therapy with defibrillator (CRT-D) patients, and 11 non-PMD patients were scanned from four major manufacturers. No device circuitry damage, programming alterations, inappropriate shocks, failure to pace, or changes in sensing, pacing, or defibrillator thresholds were found on single or multiple MRI sessions. Our protocol for MRI in CIED patients appears safe, feasible, and reproducible. This is irrespective of the type of CIED, pacemaker dependancy or multiple 24-h scanning sessions. Our protocol addresses early detection of potential complications and establishes a response system for potential device-related complications. Our observation suggests that routine DFTT/DSMT post-MRI may not be necessary.

  19. Comparison of aggregate stability within six soil profiles under conventional tillage using various laboratory tests

    Czech Academy of Sciences Publication Activity Database

    Kodešová, R.; Rohošková, M.; Žigová, Anna

    2009-01-01

    Roč. 64, č. 3 (2009), s. 550-554 ISSN 0006-3088 R&D Projects: GA ČR GA526/08/0434 Institutional research plan: CEZ:AV0Z30130516 Keywords : fast wetting test * slow wetting test * shaking after pre-wetting test * wet sewing Subject RIV: DF - Soil Science Impact factor: 0.617, year: 2009

  20. On the stability of the unit root test | Atil | Afrika Statistika

    African Journals Online (AJOL)

    Abstract. We propose to study, by two different approaches, Bayesian and classical, the test of the hypothesis of stationary first order autoregressive model against the random walk model. Therefore, we are going to present the classical approach and the Bayesian approach of this test says the unit root test. The principal ...

  1. Design and evaluation of a 3 million DN series-hybrid thrust bearing. [stability tests and fatigue tests

    Science.gov (United States)

    Scibbe, H. W.; Winn, L. W.; Eusepi, M.

    1976-01-01

    The bearing, consisting of a 150-mm ball bearing and a centrifugally actuated, conical, fluid-film bearing, was fatigue tested. Test conditions were representative of a mainshaft ball bearing in a gas turbine engine operating at maximum thrust load to simulate aircraft takeoff conditions. Tests were conducted up to 16000 rpm and at this speed an axial load of 15568 newtons (3500 lb) was safely supported by the hybrid bearing system. Through the series-hybrid bearing principle, the effective ball bearing speed was reduced to approximately one-half of the shaft speed. It was concluded that a speed reduction of this magnitude results in a ten-fold increase in the ball bearing fatigue life. A successful evaluation of fluid-film bearing lubricant supply failure was performed repeatedly at an operating speed of 10,000 rpm. A complete and smooth changeover to full-scale ball bearing operation was effected when the oil supply to the fluid-film bearing was cut off. Reactivation of the fluid-film oil supply system resulted in a flawless return to the original mode of hybrid operation.

  2. Getting to grips with poor comprehenders: stability of group membership across test conditions

    DEFF Research Database (Denmark)

    Daugaard, Hanne Trebbien; Oakhill, Jane V.; Elbro, Carsten

    Reliable identification of poor comprehenders is difficult because reading comprehension tests do not measure the same thing (Keenan et al., 2014). In addition to different contents, differences in how the same test is administered may also cause instability of the definition of poor comprehenders....

  3. Mapping of Schistosomiasis and Soil-Transmitted Helminths in Namibia: The First Large-Scale Protocol to Formally Include Rapid Diagnostic Tests.

    Science.gov (United States)

    Sousa-Figueiredo, José Carlos; Stanton, Michelle C; Katokele, Stark; Arinaitwe, Moses; Adriko, Moses; Balfour, Lexi; Reiff, Mark; Lancaster, Warren; Noden, Bruce H; Bock, Ronnie; Stothard, J Russell

    2015-01-01

    Namibia is now ready to begin mass drug administration of praziquantel and albendazole against schistosomiasis and soil-transmitted helminths, respectively. Although historical data identifies areas of transmission of these neglected tropical diseases (NTDs), there is a need to update epidemiological data. For this reason, Namibia adopted a new protocol for mapping of schistosomiasis and geohelminths, formally integrating rapid diagnostic tests (RDTs) for infections and morbidity. In this article, we explain the protocol in detail, and introduce the concept of 'mapping resolution', as well as present results and treatment recommendations for northern Namibia. This new protocol allowed a large sample to be surveyed (N = 17,896 children from 299 schools) at relatively low cost (7 USD per person mapped) and very quickly (28 working days). All children were analysed by RDTs, but only a sub-sample was also diagnosed by light microscopy. Overall prevalence of schistosomiasis in the surveyed areas was 9.0%, highly associated with poorer access to potable water (OR = 1.5, Pmaps were produced and hot spots identified to better guide the national programme in drug administration, as well as targeted improvements in water, sanitation and hygiene. The RDTs employed (circulating cathodic antigen and microhaematuria for Schistosoma mansoni and S. haematobium, respectively) performed well, with sensitivities above 80% and specificities above 95%. This protocol is cost-effective and sensitive to budget limitations and the potential economic and logistical strains placed on the national Ministries of Health. Here we present a high resolution map of disease prevalence levels, and treatment regimens are recommended.

  4. Mapping of Schistosomiasis and Soil-Transmitted Helminths in Namibia: The First Large-Scale Protocol to Formally Include Rapid Diagnostic Tests.

    Directory of Open Access Journals (Sweden)

    José Carlos Sousa-Figueiredo

    Full Text Available Namibia is now ready to begin mass drug administration of praziquantel and albendazole against schistosomiasis and soil-transmitted helminths, respectively. Although historical data identifies areas of transmission of these neglected tropical diseases (NTDs, there is a need to update epidemiological data. For this reason, Namibia adopted a new protocol for mapping of schistosomiasis and geohelminths, formally integrating rapid diagnostic tests (RDTs for infections and morbidity. In this article, we explain the protocol in detail, and introduce the concept of 'mapping resolution', as well as present results and treatment recommendations for northern Namibia.This new protocol allowed a large sample to be surveyed (N = 17,896 children from 299 schools at relatively low cost (7 USD per person mapped and very quickly (28 working days. All children were analysed by RDTs, but only a sub-sample was also diagnosed by light microscopy. Overall prevalence of schistosomiasis in the surveyed areas was 9.0%, highly associated with poorer access to potable water (OR = 1.5, P<0.001 and defective (OR = 1.2, P<0.001 or absent sanitation infrastructure (OR = 2.0, P<0.001. Overall prevalence of geohelminths, more particularly hookworm infection, was 12.2%, highly associated with presence of faecal occult blood (OR = 1.9, P<0.001. Prevalence maps were produced and hot spots identified to better guide the national programme in drug administration, as well as targeted improvements in water, sanitation and hygiene. The RDTs employed (circulating cathodic antigen and microhaematuria for Schistosoma mansoni and S. haematobium, respectively performed well, with sensitivities above 80% and specificities above 95%.This protocol is cost-effective and sensitive to budget limitations and the potential economic and logistical strains placed on the national Ministries of Health. Here we present a high resolution map of disease prevalence levels, and treatment regimens are

  5. Structural Stability Monitoring of a Physical Model Test on an Underground Cavern Group during Deep Excavations Using FBG Sensors

    Directory of Open Access Journals (Sweden)

    Yong Li

    2015-08-01

    Full Text Available Fiber Bragg Grating (FBG sensors are comprehensively recognized as a structural stability monitoring device for all kinds of geo-materials by either embedding into or bonding onto the structural entities. The physical model in geotechnical engineering, which could accurately simulate the construction processes and the effects on the stability of underground caverns on the basis of satisfying the similarity principles, is an actual physical entity. Using a physical model test of underground caverns in Shuangjiangkou Hydropower Station, FBG sensors were used to determine how to model the small displacements of some key monitoring points in the large-scale physical model during excavation. In the process of building the test specimen, it is most successful to embed FBG sensors in the physical model through making an opening and adding some quick-set silicon. The experimental results show that the FBG sensor has higher measuring accuracy than other conventional sensors like electrical resistance strain gages and extensometers. The experimental results are also in good agreement with the numerical simulation results. In conclusion, FBG sensors could effectively measure small displacements of monitoring points in the whole process of the physical model test. The experimental results reveal the deformation and failure characteristics of the surrounding rock mass and make some guidance for the in situ engineering construction.

  6. Feasibility, stability and validity of the four square step test in typically developed children and children with brain damage.

    Science.gov (United States)

    Leizerowitz, Gil; Katz-Leurer, Michal

    2017-01-01

    To assess feasibility, test-retest reliability and validity of the Four Square Step Test (FSST) in typically developed children (TD), and children with cerebral palsy (CP) and acquired brain injury (ABI). 30 TD children, 20 with CP and 12 with ABI participated in the study. The FSST while sitting and standing, the Timed Up and Go (TUG) and the balance subtest of the Bruininks-Oseretsky Test (BOT-2) were assessed. Each child attempted the FSST twice within 1 week. The scores for the FSST were assigned according to the original test: two successes in four trials, and according to a more lenient test, one success in four trials. The original form of the FSST is not feasible for children with CP or ABI. In TD children the lenient version is feasible (93%) and has moderate stability (Interclass correlation, ICC = 0.723), with a significant, positive correlation with the TUG (r s = 0.56). In children with CP the lenient test is feasible (80%), stable (r s = 0.83) and negatively correlates with the BOT-2 (r s =-0.69). In children with ABI the test is less feasible (67%) and neither stable nor valid. The lenient form of the FSST is feasible, reliable and valid in TD children and children with CP.

  7. Importance of Fuel Cell Tests for Stability Assessment—Suitability of Titanium Diboride as an Alternative Support Material

    Directory of Open Access Journals (Sweden)

    Christina Roth

    2014-06-01

    Full Text Available Carbon corrosion is a severe issue limiting the long-term stability of carbon-supported catalysts, in particular in the highly dynamic conditions of automotive applications. (Doped oxides have been discussed as suitable alternatives to replace carbon, but often suffer from poor electron conductivity. That is why non-oxide ceramics, such as tungsten carbide and titanium nitride, have been discussed recently. Titanium diboride has also been proposed, due to its promising activity and stability in an aqueous electrochemical cell. In this work, Pt nanoparticles were deposited onto μm-sized TiB2 particles with improved grain size, manufactured into porous gas diffusion electrodes and tested in a realistic polymer electrolyte membrane (PEM fuel cell environment. In contrast to the model studies in an aqueous electrochemical cell, in the presence of oxygen and high potentials at the cathode side of a real fuel cell, TiB2 becomes rapidly oxidized as indicated by intensely colored regions in the membrane-electrode assembly (MEA. Moreover, already the electrode manufacturing process led to the formation of titanium oxides, as shown by X-ray diffraction measurements. This demonstrates that Cyclic Voltammetry (CV measurements in an aqueous electrochemical cell are not sufficient to prove stability of novel materials for fuel cell applications.

  8. Laboratory and Field Test of Movable Conduction-Cooled High-Temperature SMES for Power System Stability Enhancement

    DEFF Research Database (Denmark)

    Fang, Jiakun; Wen, J.; Wang, S.

    2013-01-01

    ’ effectiveness on improvements of system voltage stability and on the oscillation damping. Test results indicate that the SMES system has the features of fast response and four-quadrant power operation. The accessories for the movability of the SEMS system are well designed. The system is feasible to be used...... in power systems.......This paper introduces the first movable conduction-cooled high temperature superconducting magnetic energy storage (SMES) system developed in China. The SMES is rated at 380 V / 35 kJ / 7 kW, consisting of the high temperature magnet confined in a dewar, the cryogenic unit, the converter...

  9. Cryptographic Protocols:

    DEFF Research Database (Denmark)

    Geisler, Martin Joakim Bittel

    with a variant of the classic BGW protocol. The protocol is secure against a semi-honest adversary. In Chapter 4 we describe a new protocol for VIFF that is secure against malicious adversaries. The protocol guarantees termination if the adversary allows a preprocessing phase to terminate, in which...... systems hosted by an untrusted provider. It guarantees atomic read and write operations on the shared data when the service is correct and preserves fork-linearizability when the service is faulty. A prototype has been implemented on top of the Subversion revision control system; benchmarks show...

  10. Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Electrostatic protocol treatment lens. The purpose of this device is to transport Antiprotons from the new ELENA storage beam to all AD experiments. The electrostatic device was successfully tested in ASACUSA two weeks ago.

  11. 4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4 August 2011 - Austrian Head of Protocol, Directorate General III, Federal Ministry of Science and Research I. Friedrich (3rd from left) in the LHC superconducting magnet test hall with M. Benedkit, C. Wulz and C. Fabjan.

  12. Pain, motion and function comparison of two exercise protocols for the rotator cuff and scapular stabilizers in patients with subacromial syndrome.

    Science.gov (United States)

    Vallés-Carrascosa, Eva; Gallego-Izquierdo, Tomás; Jiménez-Rejano, José Jesús; Plaza-Manzano, Gustavo; Pecos-Martín, Daniel; Hita-Contreras, Fidel; Achalandabaso Ochoa, Alexander

    2018-01-09

    Randomized clinical trial. Eccentric exercise (EE) was shown to be an effective treatment in tendinopathies. However, the evidence of its effectiveness in subacromial syndrome (SS) is scarce. Moreover, consensus has not been reached on whether best results for SS are obtained by means of EE with or without pain. The purpose of this is to compare the effect on pain, active range of motion (AROM), and shoulder function of an exercise protocol performed with pain shoulder function using the modified Constant-Murley Score (CMS) before and after intervention. All dependent variables improved significantly in both groups (P shoulder AROM. Furthermore, PEE does not provide greater benefits. Further studies are needed with long-term follow-up to reinforce these results. Copyright © 2017. Published by Elsevier Inc.

  13. Electrochemical Tests to Evaluate the Stability of the Anodic Films on Dental Implants

    Directory of Open Access Journals (Sweden)

    C. E. B. Marino

    2011-01-01

    Full Text Available The stability of anodic films potentiodynamically grown on titanium, titanium-grade 2, and Ti6Al4V alloy was studied in a simulated physiological electrolyte, up to 8.0 V, and at room temperature to determine the corrosion resistance levels of dental implants. In PBS (phosphate buffer saline solution, thin titanium oxide films protect the surface of the Ti6%Al4%V alloy up to 6.0 V, pure Ti up to 8.0 V, and Ti-grade 2 up to 1.5 V. At more positive potentials, localized corrosion starts to occur possibly due to the alloy elements (Ti6Al4V-V and Al and variable levels of interstitials (Ti-grade 2: C, N, and Fe, mainly. When the biomaterials were submitted to open-circuit conditions, in artificial saliva, the worst corrosion resistance was observed in dental implant (Ti-grade 2, according to the open-circuit potential values and reconstruction rate analysis of these oxide films. The XPS spectra revealed TiO2 oxide as the main phase in the barrier oxide film coating the dental implant.

  14. Aeroelastic and stability behaviour of the WTS 3 Maglarp wind turbine. Calculations and comparisons with tests

    Energy Technology Data Exchange (ETDEWEB)

    Soederberg, M.

    1990-01-01

    The GAROS system for general analysis of rotating aeroelastic structures is used to analyse the behaviour of the WTS 3 Maglarp wind turbine, situated in Maglarp, Sweden. The GAROS method is based on a branch mode technique and modal reduction. Stability analyses of the total tower-rotor system as well as numerical time integration analyses are performed within the GAROS system. The FE-model made by Anders Henoch, AIMS, for FFA is used as a base for this investigation. Some modifications concerning center of gravity of the rotor and teeter bearing/hinge have been made in the finite element model. In this report simulated values of loads in the blades are compaed to measured data. The unstable yaw behaviour of the WTS 3 was also found in the behaviour of the model. The amount of yaw-angle rotation in the model was also found to be according to measured values when induced velocities were accounted for in the aerodynamic force calculations. The analyses in general show good agreement between simulated and measured values. This paper was presented at the European Wind Energy Conference in Glasgow, 10-13 July, 1989.

  15. A note on imperfect hedging: a method for testing stability of the hedge ratio

    Directory of Open Access Journals (Sweden)

    Michal Černý

    2012-01-01

    Full Text Available Companies producing, processing and consuming commodities in the production process often hedge their commodity expositions using derivative strategies based on different, highly correlated underlying commodities. Once the open position in a commodity is hedged using a derivative position with another underlying commodity, the appropriate hedge ratio must be determined in order the hedge relationship be as effective as possible. However, it is questionable whether the hedge ratio determined at the inception of the risk management strategy remains stable over the whole period for which the hedging strategy exists. Usually it is assumed that in the short run, the relationship (say, correlation between the two commodities remains stable, while in the long run it may vary. We propose a method, based on statistical theory of stability, for on-line detection whether market movements of prices of the commodities involved in the hedge relationship indicate that the hedge ratio may have been subject to a recent change. The change in the hedge ratio decreases the effectiveness of the original hedge relationship and creates a new open position. The method proposed should inform the risk manager that it could be reasonable to adjust the derivative strategy in a way reflecting the market conditions after the change in the hedge ratio.

  16. A simple test for the stability of a black hole by S-deformation

    Science.gov (United States)

    Kimura, Masashi

    2017-12-01

    We study a sufficient condition for proving the stability of a black hole when the master equation for linear perturbation takes the form of the Schrödinger equation. If the potential contains a small negative region, the S-deformation method is usually used to show the non-existence of an unstable mode. However, in some cases, it is hard to find an appropriate deformation function analytically because the only way found so far to find it is by trial-and-error. In this paper, we show that it is easy to find a regular deformation function by numerically solving the differential equation such that the deformed potential vanishes everywhere, when the spacetime is stable. Even if the spacetime is almost marginally stable, our method still works. We also discuss a simple toy model which can be solved analytically, and show that the condition for the non-existence of a bound state is the same as that for the existence of a regular solution for the differential equation in our method. From these results, we conjecture that our criteria is also a necessary condition.

  17. Use of coal fly ash and other waste products in soil stabilization and road construction including non-destructive testing of roadways.

    Science.gov (United States)

    2012-06-01

    An extensive laboratory testing program was performed on subgrade soils stabilized using fly ash and : lime kiln dust. The laboratory program included measurements of: compaction curves, small strain elastic moduli, : resilient modulus (Mr), Briaud C...

  18. Use of coal fly ash and other waste products in soil stabilization and road construction-including non-destructive testing of roadways.

    Science.gov (United States)

    2012-02-01

    An extensive laboratory testing program was performed on subgrade soils stabilized using fly ash and lime kiln dust. The laboratory : program included measurements of: compaction curves, small strain elastic moduli, resilient modulus (Mr), Briaud Com...

  19. Determination of Stability from Multicomponent Pesticide Mixes.

    Science.gov (United States)

    Dorweiler, Kelly J; Gurav, Jagdish N; Walbridge, James S; Ghatge, Vishwas S; Savant, Rahul H

    2016-08-10

    A study was conducted to evaluate the stability of 528 pesticides, metabolites, and contaminants prepared in large multicomponent mixes to enhance laboratory efficiency by allowing maximum use of the useful shelf life of the mixtures. Accelerated aging at 50 °C simulated 6 month, 1 year, and 2 year storage periods at -20 °C. Initial mixture composition was based on the instrument of analysis. After preliminary stability data had been obtained, mixtures were reformulated and re-evaluated. In all, 344 compounds showed satisfactory stability across all treatment groups, 100 compounds showed statistically significant changes between the control and the 6 month simulated storage period (27 with losses >20%), and the remainder showed borderline stability or were tested in one protocol. Stability behavior for organophosphates agreed with the proposed reaction mechanism responsible for acetylcholinesterase inhibition. A small number of compounds increased in response over time, suggesting the occurrence of degradation of precursor pesticides into these respective compounds.

  20. Acquisition of Co metal from spent lithium-ion battery using emulsion liquid membrane technology and emulsion stability test

    Science.gov (United States)

    Yuliusman; Wulandari, P. T.; Amiliana, R. A.; Huda, M.; Kusumadewi, F. A.

    2018-03-01

    Lithium-ion batteries are the most common type to be used as energy source in mobile phone. The amount of lithium-ion battery wastes is approximated by 200 – 500 ton/year. In one lithium-ion battery, there are 5 – 20% of cobalt metal, depend on the manufacturer. One of the way to recover a valuable metal from waste is leaching process then continued with extraction, which is the aim of this study. Spent lithium-ion batteries will be characterized with EDX and AAS, the result will show the amount of cobalt metal with form of LiCoO2 in the cathode. Hydrochloric acid concentration used is 4 M, temperature 80°C, and reaction time 1 hour. This study will discuss the emulsion stability test on emulsion liquid membrane. The purpose of emulsion stability test in this study was to determine optimum concentration of surfactant and extractant to produce a stable emulsion. Surfactant and extractant used were SPAN 80 and Cyanex 272 respectively with both concentrations varied. Membrane and feed phase ratios used in this experiment was 1 : 2. The optimum results of this study were SPAN 80 concentrations of 10% w/v and Cyanex 272 0.7 M.

  1. Stability Test of Partially Purified Bromelain from Pineapple (Ananas comosus (L.) Merr) Core Extract in Artificial Stomach Fluid

    Science.gov (United States)

    Setiasih, S.; Adimas, A. Ch. D.; Dzikria, V.; Hudiyono, S.

    2018-01-01

    This study aimed to isolate and purify bromelain from pineapple core (Ananascomosus (L.) Merr) accompanied by a stability test of its enzyme activity in artificial gastric juice. Purification steps start with fractionation by a precipitation method were carried out stepwise using several concentration of ammonium sulfate salt, followed by dialysis prosess and ion exchange chromatography on DEAE-cellulose column. Each step of purification produced an increasing specific activity in enzyme fraction, starting with crude extract, respectively: 0.276 U/mg; 14.591 U/mg; and 16.05 U/mg. Bromelain fraction with the highest level of purity was obtained in 50-80% ammonium sulphate fraction after dialyzed in the amount of 58.15 times compared to the crude extract. Further purification of the enzyme by DEAE-cellulose column produced bromelain which had a purity level 160-fold compared to crude enzyme. The result of bromelain stability test in artificial stomach juice by milk clotting units assay bromelain fraction have proteolytic activity in clotting milk substrate. Exposing bromelain fraction in artificial stomach juice which gave the highest core bromelain proteolytic activity was achieved at estimated volume of 0.4-0.5 mL. Exposure in a period of reaction time to artificial stomach juice that contained pepsin showed relatively stable proteolytic activity in the first 4 hours.

  2. EMTP based stability analysis of space station electric power system in a test bed environment

    Science.gov (United States)

    Dravid, Narayan V.; Kacpura, Thomas J.; Oconnor, Andrew M.

    1992-01-01

    The Space Station Freedom Electric Power System (EPS) will convert solar energy into electric energy and distribute the same using an 'all dc', Power Management and Distribution (PMAD) System. Power conditioning devices (dc to dc converters) are needed to interconnect parts of this system operating at different nominal voltage levels. Operation of such devices could generate under damped oscillations (instability) under certain conditions. Criteria for instability are examined and verified for a single device. Suggested extension of the criteria to a system operation is examined by using the EMTP model of the PMAD DC test bed. Wherever possible, data from the test bed is compared with the modeling results.

  3. Assessment of engineering plant analyzer with Peach Bottom 2 stability tests

    International Nuclear Information System (INIS)

    Rohatgi, U.S.; Mallen, A.N.; Cheng, H.S.; Wulff, W.

    1992-01-01

    Engineering Plant Analyzer (EPA) has been developed to simulate plant transients for Boiling Water Reactor (BWR). Recently, this code has been used to simulate LaSalle-2 instability event which was initiated by a failure in the feed water heater. The simulation was performed for the scram conditions and for the postulated failure in the scram. In order to assess the capability of the EPA to simulate oscillatory flows as observed in the LaSalle event, EPA has been benchmarked with the available data from the Peach Bottom 2 (PB2) Instability tests PT1, PT2, and PT4. This document provides a description of these tests

  4. Intervention to Match Young Black Men and Transwomen Who Have Sex With Men or Transwomen to HIV Testing Options (All About Me): Protocol for a Randomized Controlled Trial.

    Science.gov (United States)

    Koblin, Beryl; Hirshfield, Sabina; Chiasson, Mary Ann; Wilton, Leo; Usher, DaShawn; Nandi, Vijay; Hoover, Donald R; Frye, Victoria

    2017-12-19

    HIV testing is a critical component of HIV prevention and care. Interventions to increase HIV testing rates among young black men who have sex with men (MSM) and black transgender women (transwomen) are needed. Personalized recommendations for an individual's optimal HIV testing approach may increase testing. This randomized trial tests the hypothesis that a personalized recommendation of an optimal HIV testing approach will increase HIV testing more than standard HIV testing information. A randomized trial among 236 young black men and transwomen who have sex with men or transwomen is being conducted. Participants complete a computerized baseline assessment and are randomized to electronically receive a personalized HIV testing recommendation or standard HIV testing information. Follow-up surveys are conducted online at 3 and 6 months after baseline. The All About Me randomized trial was launched in June 2016. Enrollment is completed and 3-month retention is 92.4% (218/236) and has exceeded study target goals. The All About Me intervention is an innovative approach to increase HIV testing by providing a personalized recommendation of a person's optimal HIV testing approach. If successful, optimizing this intervention for mobile devices will widen access to large numbers of individuals. ClinicalTrial.gov NCT02834572; https://clinicaltrials.gov/ct2/show/NCT02834572 (Archived by WebCite at http://www.webcitation.org/6vLJWOS1B). ©Beryl Koblin, Sabina Hirshfield, Mary Ann Chiasson, Leo Wilton, DaShawn Usher, Vijay Nandi, Donald R Hoover, Victoria Frye. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 19.12.2017.

  5. Calf-raise senior: a new test for assessment of plantar flexor muscle strength in older adults: protocol, validity, and reliability

    Directory of Open Access Journals (Sweden)

    André HI

    2016-11-01

    Full Text Available Helô-Isa André,1 Filomena Carnide,1 Edgar Borja,2 Fátima Ramalho,1,2 Rita Santos-Rocha,1,2 António P Veloso1 1Laboratory of Biomechanics and Functional Morphology, Interdisciplinary Study Centre for Human Performance (CIPER, Faculty of Human Kinetics (FMH, University of Lisbon, Portugal; 2Sports Science School of Rio Maior (ESDRM, Polytechnic Institute of Santarém, Portugal Purpose: This study aimed to develop a new field test protocol with a standardized measurement of strength and power in plantar flexor muscles targeted to functionally independent older adults, the calf-raise senior (CRS test, and also evaluate its reliability and validity.Patients and methods: Forty-one subjects aged 65 years and older of both sexes participated in five different cross-sectional studies: 1 pilot (n=12; 2 inter- and intrarater agreement (n=12; 3 construct (n=41; 4 criterion validity (n=33; and 5 test–retest reliability (n=41. Different motion parameters were compared in order to define a specifically designed protocol for seniors. Two raters evaluated each participant twice, and the results of the same individual were compared between raters and participants to assess the interrater and intrarater agreement. The validity and reliability studies involved three testing sessions that lasted 2 weeks, including a battery of functional fitness tests, CRS test in two occasions, accelerometry, and strength assessments in an isokinetic dynamometer.Results: The CRS test presented an excellent test–retest reliability (intraclass correlation coefficient [ICC] =0.90, standard error of measurement =2.0 and interrater reliability (ICC =0.93–0.96, as well as a good intrarater agreement (ICC =0.79–0.84. Participants with better results in the CRS test were younger and presented higher levels of physical activity and functional fitness. A significant association between test results and all strength parameters (isometric, r=0.87, r2=0.75; isokinetic, r=0.86, r2

  6. Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing.

    Science.gov (United States)

    Whiley, Phillip J; de la Hoya, Miguel; Thomassen, Mads; Becker, Alexandra; Brandão, Rita; Pedersen, Inge Sokilde; Montagna, Marco; Menéndez, Mireia; Quiles, Francisco; Gutiérrez-Enríquez, Sara; De Leeneer, Kim; Tenés, Anna; Montalban, Gemma; Tserpelis, Demis; Yoshimatsu, Toshio; Tirapo, Carole; Raponi, Michela; Caldes, Trinidad; Blanco, Ana; Santamariña, Marta; Guidugli, Lucia; de Garibay, Gorka Ruiz; Wong, Ming; Tancredi, Mariella; Fachal, Laura; Ding, Yuan Chun; Kruse, Torben; Lattimore, Vanessa; Kwong, Ava; Chan, Tsun Leung; Colombo, Mara; De Vecchi, Giovanni; Caligo, Maria; Baralle, Diana; Lázaro, Conxi; Couch, Fergus; Radice, Paolo; Southey, Melissa C; Neuhausen, Susan; Houdayer, Claude; Fackenthal, Jim; Hansen, Thomas Van Overeem; Vega, Ana; Diez, Orland; Blok, Rien; Claes, Kathleen; Wappenschmidt, Barbara; Walker, Logan; Spurdle, Amanda B; Brown, Melissa A

    2014-02-01

    Accurate evaluation of unclassified sequence variants in cancer predisposition genes is essential for clinical management and depends on a multifactorial analysis of clinical, genetic, pathologic, and bioinformatic variables and assays of transcript length and abundance. The integrity of assay data in turn relies on appropriate assay design, interpretation, and reporting. We conducted a multicenter investigation to compare mRNA splicing assay protocols used by members of the ENIGMA (Evidence-Based Network for the Interpretation of Germline Mutant Alleles) consortium. We compared similarities and differences in results derived from analysis of a panel of breast cancer 1, early onset (BRCA1) and breast cancer 2, early onset (BRCA2) gene variants known to alter splicing (BRCA1: c.135-1G>T, c.591C>T, c.594-2A>C, c.671-2A>G, and c.5467+5G>C and BRCA2: c.426-12_8delGTTTT, c.7988A>T, c.8632+1G>A, and c.9501+3A>T). Differences in protocols were then assessed to determine which elements were critical in reliable assay design. PCR primer design strategies, PCR conditions, and product detection methods, combined with a prior knowledge of expected alternative transcripts, were the key factors for accurate splicing assay results. For example, because of the position of primers and PCR extension times, several isoforms associated with BRCA1, c.594-2A>C and c.671-2A>G, were not detected by many sites. Variation was most evident for the detection of low-abundance transcripts (e.g., BRCA2 c.8632+1G>A Δ19,20 and BRCA1 c.135-1G>T Δ5q and Δ3). Detection of low-abundance transcripts was sometimes addressed by using more analytically sensitive detection methods (e.g., BRCA2 c.426-12_8delGTTTT ins18bp). We provide recommendations for best practice and raise key issues to consider when designing mRNA assays for evaluation of unclassified sequence variants.

  7. Full-scale testing, production and cost analysis data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

    Science.gov (United States)

    Aniversario, R. B.; Harvey, S. T.; Mccarty, J. E.; Parsons, J. T.; Peterson, D. C.; Pritchett, L. D.; Wilson, D. R.; Wogulis, E. R.

    1983-01-01

    The full scale ground test, ground vibration test, and flight tests conducted to demonstrate a composite structure stabilizer for the Boeing 737 aircraft and obtain FAA certification are described. Detail tools, assembly tools, and overall production are discussed. Cost analyses aspects covered include production costs, composite material usage factors, and cost comparisons.

  8. The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna

    DEFF Research Database (Denmark)

    Cupi, Denisa; Hartmann, Nanna Isabella Bloch; Baun, Anders

    2015-01-01

    dioxide (TiO2) ENPs with Daphnia magna were carried out following Organisation for Economic Co-operation and Development test guidelines. Daphnia magna was found to be very sensitive to Ag ENPs (48-h 50% effective concentration 33μgL-1), and aging of the test suspensions in M7 medium (up to 48h) did......The present study investigated changes in suspension stability and ecotoxicity of engineered nanoparticles (ENPs) by addition of Suwannee River natural organic matter and aging of stock and test suspensions prior to testing. Acute toxicity tests of silver (Ag), zinc oxide (ZnO), and titanium...... not decrease toxicity significantly. Conversely, the presence of Suwannee River natural organic matter (NOM; 20mgL-1) completely alleviated Ag ENP toxicity in all testing scenarios and did not aid in stabilizing suspensions. In contrast, addition of Suwannee River NOM stabilized ZnO ENP suspensions and did...

  9. A Simple Test to Evaluate the Calibration Stability and Accuracy of Infrared Thermocouple Sensors

    OpenAIRE

    Pinnock, Derek R.; Bugbee, Bruce

    2002-01-01

    Accurately measuring surface temperature is not difficult when the surface, the sensor, and air temperatures are similar, but it is challenging when the surface temperature is significantly different than air and sensor temperatures. We tested three Infrared Thermocouple sensors (IRT’s) that had been used for two years in a greenhouse environment. The importance of the correction for sensor body temperature was also examined.

  10. Stability and control flight test results of the space transportation system's orbiter

    Science.gov (United States)

    Culp, M. A.; Cooke, D. R.

    1982-01-01

    Flight testing of the Space Shuttle Orbiter is in progress and current results of the post-flight aerodynamic analyses are discussed. The purpose of these analyses is to reduce the pre-flight aerodynamic uncertainties, thereby leading to operational certification of the Orbiter flight envelope relative to the integrated airframe and flight control system. Primary data reduction is accomplished with a well documented maximum likelihood system identification techniques.

  11. High current 66 kV tests on high stability PFN discharge capacitors for CERN LHC

    CERN Document Server

    Barnes, M J

    1999-01-01

    The European Laboratory for Particle Physics (CERN) is constructing a Large Hadron Collider (LHC) to be installed in an existing 27 km circumference tunnel. The LHC will be equipped with fast pulsed magnet systems for injecting two counter-rotating hadron beams. Two pulsed systems, of 4 magnets and 4 pulse forming networks (PFNs) each, are required for this purpose. TRIUMF will build and test 5 resonant charging power supplies (RCPS) and nine PFNs and the associated thyratron switch units as part of the Canadian contribution to CERN LHC. Failures in the PFN capacitors may lead to incorrect beam deflections that may in turn damage LHC components. For this reason the reliability of the capacitors must be exceptionally high. Hence sample PFN capacitors were purchased and tested. The test procedure included discharging the PFN capacitors from 66 kV, into a 10.1 Ohm resistance, for 500,000 cycles, at a frequency of approximately 1 Hz. Subsequently the PFN capacitors were discharged from 66 kV into a 2.7 Ohm resist...

  12. Stability test using an inductive heater on the ITER CS insert coil

    International Nuclear Information System (INIS)

    Ozeki, Hidemasa; Suwa, Tomone; Isono, Takaaki; Takahashi, Yoshikazu; Nabara, Yoshihiro; Kawano, Katsumi; Saito, Toru

    2016-01-01

    For the stable operation of the Central Solenoid (CS) coil of the ITER without quenching, it is important to know the threshold of allowable external heating energy the CS conductor can be subjected to during operation. To evaluate the minimum quench energy of the CS conductor for the ITER, an inductive heating test was performed during the CS Insert Coil (CSIC) test campaign. A 59-turn inductive heater installed on the central turn of the CSIC was used to apply the heat energy. The heating energy from the inductive heater was calibrated by calorimetry using short conductor samples with inductive heater windings and a resistive heater. A series of inductive heating tests was performed while applying a 45.1 kA current and 12.5 T backup field on the CSIC. The alternating current (AC) applied for the inductive heater was 1,000 Hz in 40 ms, and the amplitude of the AC was varied until a quench occurred. As the result, it was obtained that the minimum quench energy for the CSIC heated by eddy current was 0.23 J/cm 3 without including the joule heating energy of the heater itself. (author)

  13. Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol.

    NARCIS (Netherlands)

    van Dartel, D.A.; Zeijen, N.J.; de la Fonteyne-Blankestijn, L.J.J.; van Schooten, F.J.; Piersma, A.H.

    2009-01-01

    The mouse embryonic stem cell test (EST) was designed to predict embryotoxicity based on the inhibition of the differentiation of embryonic stem cells (ESC) into beating cardiomyocytes in combination with cytotoxicity data in monolayer ESC cultures and 3T3 cells. In the present study, we have tested

  14. Blood test ordering for unexplained complaints in general practice: the VAMPIRE randomised clinical trial protocol. [ISRCTN55755886

    NARCIS (Netherlands)

    van Bokhoven, Marloes A.; Koch, Hèlen; van der Weijden, Trudy; Grol, Richard P. T. M.; Bindels, Patrick J. E.; Dinant, Geert-Jan

    2006-01-01

    BACKGROUND: General practitioners (GPs) frequently order blood tests when they see patients presenting with unexplained complaints. Due to the low prevalence of serious pathology in general practice, the risk of false-positive test results is relatively high. This may result in unnecessary further

  15. Audit of HIV counselling and testing services among primary healthcare facilities in Cameroon: a protocol for a multicentre national cross-sectional study.

    Science.gov (United States)

    Tianyi, Frank-Leonel; Tochie, Joel Noutakdie; Agbor, Valirie Ndip; Kadia, Benjamin Momo

    2018-03-01

    HIV testing is an invaluable entry point to prevention, care and treatment services for people living with HIV and AIDS. Poor adherence to recommended protocols and guidelines reduces the performance of rapid diagnostic tests, leading to misdiagnosis and poor estimation of HIV seroprevalence. This study seeks to evaluate the adherence of primary healthcare facilities in Cameroon to recommended HIV counselling and testing (HCT) procedures and the impact this may have on the reliability of HIV test results. This will be an analytical cross-sectional study involving primary healthcare facilities from all the 10 regions of Cameroon, selected by a multistaged random sampling of primary care facilities in each region. The study will last for 9 months. A structured questionnaire will be used to collect general information concerning the health facility, laboratory and other departments involved in the HCT process. The investigators will directly observe at least 10 HIV testing processes in each facility and fill out the checklist accordingly. Clearance has been obtained from the National Ethical Committee to carry out the study. Informed consent will be sought from the patients to observe the HIV testing process. The final study will be published in a peer-reviewed journal and the findings presented to health policy-makers and the general public. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  16. Feasibility results of an electromagnetic compatibility test protocol to evaluate medical devices to radio frequency identification exposure.

    Science.gov (United States)

    Seidman, Seth J; Bekdash, Omar; Guag, Joshua; Mehryar, Maryam; Booth, Paul; Frisch, Paul

    2014-08-03

    The use of radio frequency identification (RFID) systems in healthcare is increasing, and concerns for electromagnetic compatibility (EMC) pose one of the biggest obstacles for widespread adoption. Numerous studies have demonstrated that RFID systems can interfere with medical devices; however, the majority of past studies relied on time-consuming and burdensome test schemes based on ad hoc test methods applied to individual RFID systems. This paper presents the results of using an RFID simulator that allows for faster evaluation of RFID-medical device EMC against a library of RFID test signals at various field strengths. The results of these tests demonstrate the feasibility and adequacy of simulator testing and can be used to support its incorporation into applicable consensus standards. This work can aid the medical device community in better assessing the risks associated with medical device exposure to RFID.

  17. Dynamic Stability and Risk of Tripping during the Timed Up and Go Test in Hemiparetic and Healthy Subjects.

    Directory of Open Access Journals (Sweden)

    Céline Bonnyaud

    Full Text Available The Timed Up and Go (TUG test is often used to estimate risk of falls. Foot clearance and displacement of the center of mass (COM, which are related to risk of tripping and dynamic stability have never been evaluated during the TUG. Accurate assessment of these parameters using instrumented measurements would provide a comprehensive assessment of risk of falls in hemiparetic patients. The aims of this study were to analyze correlations between TUG performance time and displacement of the COM and foot clearance in patients with stroke-related hemiparesis and healthy subjects during the walking and turning sub-tasks of the TUG and to compare these parameters between fallers and non-fallers.29 hemiparetic patients and 25 healthy subjects underwent three-dimensional gait analysis during the TUG test. COM and foot clearance were analyzed during the walking and turning sub-tasks of the TUG.Lateral displacement of the COM was greater and faster during the walking sub-tasks and vertical displacement of the COM was greater during the turn in the patients compared to the healthy subjects (respectively p<0.01 and p<0.05. Paretic foot clearance was greater during walking and displacement of the COM was slower during the turn in the patients (p<0.01. COM displacement and velocity during the turn were correlated with TUG performance in the patients, however, vertical COM displacement was not. These correlations were significant in the healthy subjects. There were no differences between COM parameters or foot clearance in fallers and non-fallers.Hemiparetic patients are less stable than healthy subjects, but compensate with a cautious gait to avoid tripping. Instrumented analysis of the TUG test appears relevant for the assessment of dynamic stability in hemiparetic patients, providing more information than straight-line gait.

  18. A simplified headspace biochemical oxygen demand test protocol based on oxygen measurements using a fiber optic probe.

    Science.gov (United States)

    Min, Booki; Kohler, David; Logan, Bruce E

    2004-01-01

    Batch respirometric tests have many advantages over the conventional biochemical oxygen demand (BOD) method for analysis of wastewaters, including the use of nondiluted samples, a more rapid exertion of oxygen demand, and reduced sample preparation time. The headspace biochemical oxygen demand (HBOD) test can be used to obtain oxygen demands in 2 or 3 days that can predict 5-day biochemical oxygen demand (BOD5) results. The main disadvantage of the HBOD and other respirometric tests has been the lack of a simple and direct method to measure oxygen concentrations in the gas phase. The recent commercial production of a new type of fiber optic oxygen probe, however, provides a method to eliminate this disadvantage. This fiber optic probe, referred to here as the HBOD probe, was tested to see if it could be used in HBOD tests. Gas-phase oxygen measurements made with the HBOD probe took only a few seconds and were not significantly different from those made using a gas chromatograph (t test: n = 15, R2 = 0.9995, p biochemical oxygen demand measurements on UAJA primary clarifier effluent were 59.9 +/- 2.4% after 2 days (HBOD2) and 73.0 +/- 3.1% after 3 days (HBOD) of BOD, values, indicating that BOD5 values could be predicted by multiplying HBOD2 values by 1.67 +/- 0.07 or HBOD3 by 1.37 +/- 0.06. Similarly, tests using PSU wastewater samples could be used to provide BOD5 estimates by multiplying the HBOD2 by 1.24 +/- 0.04 or by multiplying the HBOD3 by 0.97 +/- 0.03. These results indicate that the HBOD fiber optic probe can be used to obtain reliable oxygen demands in batch respirometric tests such as the HBOD test.

  19. SU-F-R-40: Robustness Test of Computed Tomography Textures of Lung Tissues to Varying Scanning Protocols Using a Realistic Phantom Environment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Markel, D; Hegyi, G [Medical Physics Unit, McGill University, Montreal, Quebec (Canada); El Naqa, I [University of Michigan, Ann Arbor, MI (United States)

    2016-06-15

    Purpose: The reliability of computed tomography (CT) textures is an important element of radiomics analysis. This study investigates the dependency of lung CT textures on different breathing phases and changes in CT image acquisition protocols in a realistic phantom setting. Methods: We investigated 11 CT texture features for radiation-induced lung disease from 3 categories (first-order, grey level co-ocurrence matrix (GLCM), and Law’s filter). A biomechanical swine lung phantom was scanned at two breathing phases (inhale/exhale) and two scanning protocols set for PET/CT and diagnostic CT scanning. Lung volumes acquired from the CT images were divided into 2-dimensional sub-regions with a grid spacing of 31 mm. The distribution of the evaluated texture features from these sub-regions were compared between the two scanning protocols and two breathing phases. The significance of each factor on feature values were tested at 95% significance level using analysis of covariance (ANCOVA) model with interaction terms included. Robustness of a feature to a scanning factor was defined as non-significant dependence on the factor. Results: Three GLCM textures (variance, sum entropy, difference entropy) were robust to breathing changes. Two GLCM (variance, sum entropy) and 3 Law’s filter textures (S5L5, E5L5, W5L5) were robust to scanner changes. Moreover, the two GLCM textures (variance, sum entropy) were consistent across all 4 scanning conditions. First-order features, especially Hounsfield unit intensity features, presented the most drastic variation up to 39%. Conclusion: Amongst the studied features, GLCM and Law’s filter texture features were more robust than first-order features. However, the majority of the features were modified by either breathing phase or scanner changes, suggesting a need for calibration when retrospectively comparing scans obtained at different conditions. Further investigation is necessary to identify the sensitivity of individual image

  20. Superiority of visual (verbal) vs. auditory test presentation modality in a P300-based CIT: The Complex Trial Protocol for concealed autobiographical memory detection.

    Science.gov (United States)

    Deng, Xiaohong; Rosenfeld, J Peter; Ward, Anne; Labkovsky, Elena

    2016-07-01

    This paper continues our efforts to determine which modality is best for presentation of stimuli in the P300-based concealed information test (CIT) called the Complex Trial Protocol (CTP). The first part of the CTP trial involves presentation of the key probe or irrelevant stimuli, and is followed by presentation of target (T) or non-target (NT). In Rosenfeld et al. (2015), probes and irrelevants regularly alternated modality over trials, but Ts and NTs were always visual. In the present study, (in both its experiments, EXP 1 and EXP 2), probes and irrelevants alternated modalities on successive trials, as before. In present EXP 1, Ts and NTs were always auditory, but in EXP 2, they were simultaneously auditory and visual. Probe P300 data were different in each study: In Rosenfeld et al. (2015) and EXP 2 here, the bootstrap-based detection rates based on probe-minus-irrelevant differences, significantly differed favoring visual probe and irrelevant presentation modality. In EXP 1 here, detection rates were the same for the two modalities. In Rosenfeld et al. (2015) there was no main effect of probe modality, visual vs. auditory on probe-minus-irrelevant P300 difference. There were such effects here in EXP 1 (pvisual modality. Probe P300 latencies were shorter for visual than for auditory stimuli in Rosenfeld et al. (2015), a trend specifically reversed in the present pair of studies. RT was faster for visual stimuli in the present studies. The T and NT modality appears to interact with probe/irrelevant modality, and the best protocol for detecting concealed information is with the 2015 study protocol or that of EXP 2, using visual stimulus presentation. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Comparative evaluation of bivalent malaria rapid diagnostic tests versus traditional methods in field with special reference to heat stability testing in Central India.

    Directory of Open Access Journals (Sweden)

    Neeru Singh

    Full Text Available Malaria presents a diagnostic challenge in areas where both Plasmodium falciparum and P.vivax are co-endemic. Bivalent Rapid Diagnostic tests (RDTs showed promise as diagnostic tools for P.falciparum and P.vivax. To assist national malaria control programme in the selection of RDTs, commercially available seven malaria RDTs were evaluated in terms of their performance with special reference to heat stability.This study was undertaken in four forested districts of central India (July, 2011- March, 2012. All RDTs were tested simultaneously in field along with microscopy as gold standard. These RDTs were stored in their original packing at 25°C before transport to the field or they were stored at 35°C and 45°C upto 100 days for testing the performance of RDTs at high temperature. In all 2841 patients with fever were screened for malaria of which 26% were positive for P.falciparum, and 17% for P.vivax. The highest sensitivity of any RDT for P.falciparum was 98% (95% CI; 95.9-98.8 and lowest sensitivity was 76% (95% CI; 71.7-79.6. For P.vivax highest and lowest sensitivity for any RDT was 80% (95% CI; 94.9 - 83.9 and 20% (95% CI; 15.6-24.5 respectively. Heat stability experiments showed that most RDTs for P.falciparum showed high sensitivity at 45°C upto 90 days. While for P.vivax only two RDTs maintained good sensitivity upto day 90 when compared with RDTs kept at room temperature. Agreement between observers was excellent for positive and negative readings for both P.falciparum and P.vivax (Kappa >0.6-0.9.This is first field evaluation of RDTs regarding their temperature stability. Although RDTs are useful as diagnostic tool for P.falciparum and P.vivax even at high temperature, the quality of RDTs should be regulated and monitored more closely.

  2. A true 3D physical model test study on the stability of an underground cavern group in Shuangjiangkou Hydropower Station

    Science.gov (United States)

    Zhu, Weishen; Zhang, Lei; Li, Yong; Zhang, Qianbing

    2010-03-01

    Taking the underground caverns of Shuangjiangkou (SJK) Hydropower Station as an engineering background, a largescale true 3D physical model test is performed to study the stability of the enclosing rock masses, including the analogous material, the steel structure frame, fabrications of rock bolts and cables, development of the measuring techniques, fabrication of the physical model, excavations and the overload test. The developed steel structure can simulate the complicated circumstances just like high in-situ stress and high overburden depth. It also can apply the true 3D loading on six surfaces of the physical model. Many combinational ball sliding blocks are installed between model surface and the structural wall to reduce the friction between the contact surfaces. During the model construction, precast blocks are used and monitoring holes are predefined before the analogous material is piled up. A unique grouting technique and prestressed cables are adopted in the model test. A digital photogrammetric technique, displacement sensing bars based on Fiber Bragg Gratings (FBG) technology, and mini extensometers are developed and adopted for measuring the deformation in the process of excavations. The overload tests are accomplished under the conditions of different overburden depths. The results of this research will make certain guiding significance to the practical engineering.

  3. Testing of High Thermal Cycling Stability of Low Strength Concrete as a Thermal Energy Storage Material

    Directory of Open Access Journals (Sweden)

    Chao Wu

    2016-09-01

    Full Text Available Concrete has the potential to become a solution for thermal energy storage (TES integrated in concentrating solar power (CSP systems due to its good thermal and mechanical properties and low cost of material. In this study, a low strength concrete (C20 is tested at high temperatures up to 600 °C. Specimens are thermally cycled at temperatures in the range of 400–300 °C, 500–300 °C, and 600–300 °C, which TES can reach in operation. For comparison, specimens also cycled at temperature in the range of 400–25 °C (room temperature, 500–25 °C, and 600–25 °C. It is found from the test results that cracks are not observed on the surfaces of concrete specimens until the temperature is elevated up to 500 °C. There is mechanical deterioration of concrete after exposure to high temperature, especially to high thermal cycles. The residual compressive strength of concrete after 10 thermal cycles between 600 °C and 300 °C is about 58.3%, but the specimens remain stable without spalling, indicating possible use of low strength concrete as a TES material.

  4. A Michelson interferometer system for testing the stability of a piezo-electric actuator intended for use in space

    International Nuclear Information System (INIS)

    Aplin, K L; Middleton, K F

    2007-01-01

    The Laser Interferometer Space Antenna (LISA) experiment will search for gravitational waves generated by cataclysmic events far back in astronomical history. LISA is an interferometer formed by three spacecraft positioned five million km apart, and to observe gravitational waves, it must monitor test mass positions with picometre level resolution. One of the numerous technological challenges is to identify an actuator with appropriate accuracy, precision and stability for positioning of the optical fibres used to deliver LISA's laser sources. We have developed a Michelson interferometer system to determine the temporal and thermal stability of candidate actuators, with an emphasis on characterisation in the milliHertz frequency range required for gravitational wave detection in space. This paper describes the interferometer data logging and calibration and presents preliminary results in the form of a 'noise spectrum' generated from the small perturbation of a nominally static mirror. The maximum displacement of the mirror was ∼50 nm with sub-Hz noise levels of 0.1-1 nm√Hz. This is within the LISA noise specification, and confirms that the apparatus is stable enough for the characterisation of the actuator

  5. Evaluation of Solvita compost stability and maturity tests for assessment of quality of end-products from mixed latrine style compost toilets

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Geoffrey B., E-mail: geoff.hill@geog.ubc.ca [University of British Columbia, Department of Geography, 1984 West Mall, Vancouver, Canada V6T 1Z2 (Canada); Baldwin, Susan A. [Chemical and Biological Engineering, University of British Columbia, 2360 East Mall, Vancouver, B.C., Canada V6T 1Z3 (Canada); Vinnerås, Bjorn [Swedish University of Agricultural Sciences, Box 7032, SE-750 07 Uppsala (Sweden)

    2013-07-15

    Highlights: • Solvita® stability and maturity tests used on composting toilet end-product. • Solvita® ammonia better suited in evaluation of feedstock suitability for vermicomposting. • No clear value of Solvita® stability test due to prevalent inhibition of decomposition by ammonia. - Abstract: It is challenging and expensive to monitor and test decentralized composting toilet systems, yet critical to prevent the mismanagement of potentially harmful and pathogenic end-product. Recent studies indicate that mixed latrine composting toilets can be inhibited by high ammonia content, a product of urea hydrolysis. Urine-diverting vermicomposting toilets are better able to accomplish the goals of remote site human waste management by facilitating the consumption of fecal matter by earthworms, which are highly sensitive to ammonia. The reliability of Solvita® compost stability and maturity tests were evaluated as a means of determining feedstock suitability for vermicomposting (ammonia) and end-product stability/completeness (carbon dioxide). A significant linear regression between Solvita® ammonia and free ammonia gas was found. Solvita® ranking of maturity did not correspond to ranking assigned by ammonium:nitrate standards. Solvita® ammonia values 4 and 5 contained ammonia levels below earthworm toxicity limits in 80% and 100% of samples respectively indicative of their use in evaluating feedstock suitability for vermicomposting. Solvita® stability tests did not correlate with carbon dioxide evolution tests nor ranking of stability by the same test, presumably due to in situ inhibition of decomposition and microbial respiration by ammonia which were reported by the Solvita® CO{sub 2} test as having high stability values.

  6. Evaluation of Solvita compost stability and maturity tests for assessment of quality of end-products from mixed latrine style compost toilets

    International Nuclear Information System (INIS)

    Hill, Geoffrey B.; Baldwin, Susan A.; Vinnerås, Bjorn

    2013-01-01

    Highlights: • Solvita® stability and maturity tests used on composting toilet end-product. • Solvita® ammonia better suited in evaluation of feedstock suitability for vermicomposting. • No clear value of Solvita® stability test due to prevalent inhibition of decomposition by ammonia. - Abstract: It is challenging and expensive to monitor and test decentralized composting toilet systems, yet critical to prevent the mismanagement of potentially harmful and pathogenic end-product. Recent studies indicate that mixed latrine composting toilets can be inhibited by high ammonia content, a product of urea hydrolysis. Urine-diverting vermicomposting toilets are better able to accomplish the goals of remote site human waste management by facilitating the consumption of fecal matter by earthworms, which are highly sensitive to ammonia. The reliability of Solvita® compost stability and maturity tests were evaluated as a means of determining feedstock suitability for vermicomposting (ammonia) and end-product stability/completeness (carbon dioxide). A significant linear regression between Solvita® ammonia and free ammonia gas was found. Solvita® ranking of maturity did not correspond to ranking assigned by ammonium:nitrate standards. Solvita® ammonia values 4 and 5 contained ammonia levels below earthworm toxicity limits in 80% and 100% of samples respectively indicative of their use in evaluating feedstock suitability for vermicomposting. Solvita® stability tests did not correlate with carbon dioxide evolution tests nor ranking of stability by the same test, presumably due to in situ inhibition of decomposition and microbial respiration by ammonia which were reported by the Solvita® CO 2 test as having high stability values

  7. Stability of Low Embankments on Soft Clay. Part 3. Centrifuge Tests and Numerical Analysis.

    Science.gov (United States)

    1984-11-01

    radiographs taken after the test. . Miniature pore pressure transducers used were the PDCR81 transducers manufactured by Druck Ltd. They are 6.35 mm...transducers at any time. The pressure was applied by a remote air/water interface and recorded in a Druck DPI 100 digital pressure meter. For the...I.. " 7 .P 1.. - l wil (dJ ) 3WS3 1 ’ X (dJ41 3NS3 ci ’ IN. 7V~ AUN I7 cu V N z V N Ncu N L coN IX ( 4 ’Hr^ 3d IX e d] f9p X W~]~lSd* X 3 L L J 0 0 00

  8. Role of diagnostic testing in identifying and resolving dimensional-stability problems in electroplated laser mirrors

    International Nuclear Information System (INIS)

    Cutler, R.L.; Hogan, B.

    1982-01-01

    The metal mirrors which are the subject of this discussion are to be used in the Antares inertial fusion laser system. Antares is a high-power (40 TW), high-energy (35 to 40 kJ), pulsed CO 2 laser system for the investigation of inertial confinement fusion. The system contains more than four hundred small and large diamond-turned and conventionally polished mirrors. The largest mirrors are trapezoidal in shape with the longest dimension being 16 to 18 inches. The substrates are type 2124 aluminum for most large mirrors, and aluminum bronze, oxygen-free copper or a copper-zirconium alloy for most of the smaller mirrors. The optical surface is electro-deposited copper 20 to 40 mils thick. After nondestructive testing and rough machining, the electroplated surface is single-point diamond machined or conventionally polished

  9. The effect of chronic corticosterone on fear learning and memory depends on dose and the testing protocol.

    Science.gov (United States)

    Marks, W N; Fenton, E Y; Guskjolen, A J; Kalynchuk, L E

    2015-03-19

    Chronic exposure to the stress hormone corticosterone (CORT) is known to alter plasticity within hippocampal and amygdalar circuits that mediate fear learning and memory. The purpose of this experiment was to clarify the effects of chronic CORT on Pavlovian fear conditioning, which is dependent on intact hippocampal and amygdalar activity. In particular, we assessed whether the effect of chronic CORT on fear learning and memory is influenced by two factors-the dose of CORT and the order in which rats are tested for freezing to context versus tone cues. Male Long-Evans rats received low-dose CORT (5mg/kg), high-dose CORT (40mg/kg), or vehicle injections once daily for 21days. On day 22, the rats were trained in a fear-conditioning paradigm. On days 23 and 24, the rats were tested for the retrieval of fear memories to context and tone cues in a counterbalanced way-half the rats received context testing on day 23 and then tone testing on day 24 and half the rats received tone testing on day 23 followed by context testing on day 24. Our results revealed dose-dependent effects of CORT on memory retrieval: Rats injected with high-dose CORT froze significantly more than control rats to both context and tone cues regardless of what testing day these cues were presented. However, rats injected with low-dose CORT froze significantly more than control rats to tone cues only. We also found an order effect in that the effects of CORT on freezing were greater on the second day of testing, regardless of whether that testing was to context or tones cues. This order effect may be due to a lack of extinction in the CORT rats. Overall, these results suggest a relationship between stress intensity and testing conditions that should be taken into account when assessing the effect of stress on fear memories. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Evidence used in model-based economic evaluations for evaluating pharmacogenetic and pharmacogenomic tests: a systematic review protocol.

    Science.gov (United States)

    Peters, Jaime L; Cooper, Chris; Buchanan, James

    2015-11-11

    Decision models can be used to conduct economic evaluations of new pharmacogenetic and pharmacogenomic tests to ensure they offer value for money to healthcare systems. These models require a great deal of evidence, yet research suggests the evidence used is diverse and of uncertain quality. By conducting a systematic review, we aim to investigate the test-related evidence used to inform decision models developed for the economic evaluation of genetic tests. We will search electronic databases including MEDLINE, EMBASE and NHS EEDs to identify model-based economic evaluations of pharmacogenetic and pharmacogenomic tests. The search will not be limited by language or date. Title and abstract screening will be conducted independently by 2 reviewers, with screening of full texts and data extraction conducted by 1 reviewer, and checked by another. Characteristics of the decision problem, the decision model and the test evidence used to inform the model will be extracted. Specifically, we will identify the reported evidence sources for the test-related evidence used, describe the study design and how the evidence was identified. A checklist developed specifically for decision analytic models will be used to critically appraise the models described in these studies. Variations in the test evidence used in the decision models will be explored across the included studies, and we will identify gaps in the evidence in terms of both quantity and quality. The findings of this work will be disseminated via a peer-reviewed journal publication and at national and international conferences. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. Differences in cytoplasmic maturation between the BCB+ and control porcine oocytes do not justify application of the BCB test for a standard IVM protocol.

    Science.gov (United States)

    Pawlak, Piotr; Warzych, Ewelina; Chabowska, Agnieszka; Lechniak, Dorota

    2014-03-07

    The Brilliant Cresyl Blue (BCB) test relies on G6PDH activity and a simple protocol for the selection of higher quality oocytes. Although the BCB+ oocytes of all the species that have been investigated are characterized by superior quality when compared to BCB- counterparts, application of the test for embryo production still remains an open issue. The aim of our study was to compare BCB+ and the control oocytes (not subjected to the BCB test) in terms of selected aspects of cytoplasmic maturation (mtDNA copy number, mitochondria distribution, relative transcript abundance of six marker genes). The results of our study revealed more relevant differences within the BCB+ and the control oocytes (before and after IVM) than between the two categories of oocytes. There was no difference in the transcript abundance of the BCB+ and the control oocytes in 5 out of 6 analyzed genes (BMP15, GDF9, ATP5A1, EEF1A, ZAR1) and in mtDNA content (pre-IVM 179609 vs. 176595 and post-IVM 187243 vs. 246984, respectively). With regard to mitochondria distribution in pre- and post-IVM oocytes, there was nonsignificant tendency for a more frequent occurrence of the expected patterns in the BCB+ group. The results of the present study do not support the application of BCB staining in a routine IVM protocol due to relatively high similarity in selected parameters characterizing cytoplasmic maturation of BCB+ and control oocytes. This high similarity may results from the limited amount of less competent BCB- oocytes (10%) still present among nonselected oocytes of proper morphology.

  12. The Taste and Smell Protocol in the 2011–2014 US National Health and Nutrition Examination Survey (NHANES): Test–Retest Reliability and Validity Testing

    Science.gov (United States)

    Rawal, Shristi; Hoffman, Howard J.; Honda, Mallory; Huedo-Medin, Tania B.; Duffy, Valerie B.

    2016-01-01

    Introduction The US NHANES 2011–2014 protocol includes a taste and smell questionnaire (CSQ) in home-based interviews and brief assessments in mobile exam centers. We report the short- and longer-term test–retest reliability and validity of this protocol against broader chemosensory measures. Methods A convenience sample of 73 adults (age=39.5±20.8 years) underwent the NHANES protocol at baseline, 2 weeks and 6 months. For taste, participants rated intensities of two tastants (1 M NaCl, 1 mM quinine) applied to the tongue tip and three tastants (1 M NaCl, 1 mM quinine, 0.32 M NaCl) sampled with the whole mouth. Smell function was assessed with a Pocket Smell Test™ (PST; eight-item odor identification test). The CSQ asked about chemosensory problems, distortions, and age-related changes. Broader baseline measurements were a 40-item olfactometer-generated identification task and additional whole-mouth taste intensities (1 M sucrose, 32 mM citric acid, 3.2 mM propylthiouracil). Results Intraclass correlations (ICCs) for NHANES taste measures showed moderate-to-good agreement after 2 weeks and 6 months (ICCs 0.42–0.71). Whole-mouth quinine intensity was significantly correlated with other taste intensities, supporting its utility as a marker for overall taste functioning. Olfactory classification from PSTs agreed for 98.5 % of participants across 2 weeks (κ=0.85; 95 % CI 0.71–0.99) and had good correspondence with the olfactometer task. CSQ items showed good-to-excellent agreement over 6 months (ICCs 0.66–0.90). Conclusions These findings further support that the NHANES chemosensory protocol has moderate-to-good test–retest reliability when administered to healthy, educated adults. Despite being a brief procedure with limited measures, the NHANES taste and smell assessments provided good information when compared to broader measures of taste and smell function. PMID:27833669

  13. The effects of HIV self-testing on the uptake of HIV testing and linkage to antiretroviral treatment among adults in Africa: a systematic review protocol.

    Science.gov (United States)

    Njau, Bernard; Damian, Damian J; Abdullahi, Leila; Boulle, Andrew; Mathews, Catherine

    2016-04-05

    HIV is still a global public health problem. More than 75 % of HIV-infected people are in Africa, and most of them are unaware of their HIV status, which is a barrier to accessing antiretroviral treatment. Our review aims, firstly, to determine whether HIV self-testing is an effective method to increase the uptake of testing, the yield of new HIV-positive diagnoses, and the linkage to antiretroviral treatment. Secondly, we aim to review the factors that facilitate or impede the uptake of HIV self-testing. Participants will be adults living in Africa. For the first aim, the intervention will be HIV self-testing either alone or in addition to HIV testing standard of care. The comparison will be HIV testing standard of care. The primary outcomes will be (i) uptake of HIV testing and (ii) yield of new HIV-positive diagnoses. The secondary outcomes will be (a) linkage to antiretroviral (ARV) treatment and (b) incidence of social harms. For the second aim, we will review barriers and facilitators to the uptake of self-testing. We will search PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, WHOLIS, Africa Wide, and CINAHL for eligible studies from 1998, with no language limits. We will check reference lists of included studies for other eligible reports. Eligible studies will include experimental and observational studies. Two authors will independently screen the search output, select studies, and extract data, resolving discrepancies by consensus and discussion. Two authors will use Cochrane risk of bias tools for experimental studies, the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Critical Appraisal Skills Programme (CASP) quality assessment tool for qualitative studies. Innovative and cost-effective community-based HIV testing strategies, such as self-testing, will contribute to universal coverage of HIV testing in Africa. The findings from this systematic review will guide development of self-testing

  14. Geneva protocols

    International Nuclear Information System (INIS)

    Kimminich, O.

    1990-01-01

    The First Protocol Additional to the Geneva Conventions of 1949 and relating to the Protection of Victims of International Armed Conflicts contains provisions prohibiting indiscriminate attacks. Nuclear warfare as such is not mentioned in the Protocol. It has been asserted that the Protocol does not apply to nuclear weapons for several reasons. However, close analysis shows that the rules governing the application of means and methods of warfare cannot exempt the nuclear weapons. If nuclear weapons are applied in a manner not consistent with article 51 of Protocol I, their use is forbidden by this article even in situations in which general international law might grant an exception from the ban on nuclear weapons, as in the case of reprisal. (orig./HSCH) [de

  15. Testing GIC Mitigation Protocols by Modelling Transformer-Level GIC Flow in New Zealand's Electrical Transmission Grid

    Science.gov (United States)

    Divett, T.; Ingham, M.; Rodger, C. J.; Richardson, G. S.; Beggan, C.; Thomson, A. W. P.; Dalzell, M.; Mac Manus, D. H.

    2017-12-01

    Transformers in the South Island of Transpower New Zealand Ltd's electrical transmission network have been impacted by geomagnetically induced currents (GIC) during geomagnetic storms, including the November 2001 event. We aim to make recommendations that lead to improving mitigation strategies for reducing these impacts during extreme events. We have adapted a thin-sheet electromagnetic and GIC network modelling approach that has previously been successfully used in the UK to New Zealand's geology and transmission network. In this presentation we show how we have used this approach to explore Transpower's mitigation procedure as well as alternative mitigation options for reducing the impact of space weather on the network. In order to compare modelled GIC with what has been described as `possibly the best GIC dataset in the world' (Boteler and Pirjola, Pers. Comm. 2016) our model includes every transformer and every high voltage transmission line in the South Island network. This level of detail was required to match the transformer level observations of GIC in the network and to appropriately assess the mitigation options at the level where the damage to power networks occurs. We found that removing a single generator at a central power station and four transmission lines is enough to effectively redistribute GIC away from transformers that have previously experienced very high GIC (as shown in Figure). The redistributed GIC is less damaging to the transformers that it is redistributed to due to lower total GIC at those locations. In the past the impact of GIC on transformers has occurred in the first two minutes of a storm. Hence, mitigation strategies that currently rely on human intervention and involving delays of up to 15 minutes may need to be initiated very rapidly, in a significant departure from Transpower's existing protocol. Reducing delays should significantly reduce the potential for damage in a storm equivalent to the 2001 event. During an extreme

  16. The Use of Risk and Return for Testing the Stability of Stock Markets

    Directory of Open Access Journals (Sweden)

    Viorica Chirilă

    2014-04-01

    Full Text Available The European Central Bank stipulates that a financial system is stable if the financial risks are evaluated and rewarded correctly and if the economic and financial shocks are absorbed. When analyzing the return and volatility of the stock exchanges we may ascertain that a stock exchange is stable if there is a connection between return and volatility and if the shocks determined by the new positive and negative information do not cause significant changes of the volatility. We took into consideration the values of the indices of stock markets from Holland (AEX, Belgium (BEL, Romania (BET, Hungary (BUX, Germany (DAX, France (CAC, Czech Republic (PX, Slovakia (SAX, Austria (ATX, Estonia (OMXT, Latvia (OMXR and Lithuania (OMXV. In order to test the relationship between return-volatility and volatility asymmetry we estimated a GJR-GARCH-M model. The results confirm the lack of existence of a correlation between return and volatility for the entire period under analysis and the existence of the volatility asymmetry.

  17. Stability and lifetime testing of photomultiplier detectors for the Earth observing system SOLSTICE program

    Science.gov (United States)

    Hadler, Joshua A.; van de Kop, Toni; Drake, Virginia A.; McClintock, William E.; Murphy, John; Rodgers, Paul

    1998-10-01

    The primary objective of the Earth Observing System (EOS) Solar Stellar Irradiance Comparison Experiment (SOLSTICE) is to accurately measure the absolute value of the solar UV irradiance at the top of the earth's atmosphere for a minimum mission lifetime of 5 years. To meet this objective, SOLSTICE employs a unique design to determine changes in instrument performance by routinely observing a series of early-type stars and comparing the irradiances directly with the solar value. Although the comparison techniques allows us to track instrument performance, the success of the SOLSTICE experiment depends upon photomultiplier detectors which have graceful degradation properties. Therefore, we have established a laboratory program to evaluate the characteristics of photomultiplier tubes which are exposed to long term fluxes similar to those we expected to encounter in flight. Three types of Hamamatsu photomultiplier tubes were tested as candidates for use in the EOS-SOLSTICE project. The results of these studies: pulse height distribution; quantum efficiency; surface maps,; and lifetime analysis are presented in this paper.

  18. A borehole stability study by newly designed laboratory tests on thick-walled hollow cylinders

    Directory of Open Access Journals (Sweden)

    S.S. Hashemi

    2015-10-01

    Full Text Available At several mineral exploration drilling sites in Australia, weakly consolidated formations mainly consist of sand particles that are poorly bonded by cementing agents such as clay, iron oxide cement or calcite. These formations are being encountered when drilling boreholes to the depth of up to 200 m. To study the behaviour of these materials, thick-walled hollow cylinder (TWHC and solid cylindrical synthetic specimens were designed and prepared by adding Portland cement and water to sand grains. The effects of different parameters such as water and cement contents, grain size distribution and mixture curing time on the characteristics of the samples were studied to identify the mixture closely resembling the formation at the drilling site. The Hoek triaxial cell was modified to allow the visual monitoring of grain debonding and borehole breakout processes during the laboratory tests. The results showed the significance of real-time visual monitoring in determining the initiation of the borehole breakout. The size-scale effect study on TWHC specimens revealed that with the increasing borehole size, the ductility of the specimen decreases, however, the axial and lateral stiffnesses of the TWHC specimen remain unchanged. Under different confining pressures the lateral strain at the initiation point of borehole breakout is considerably lower in a larger size borehole (20 mm compared to that in a smaller one (10 mm. Also, it was observed that the level of peak strength increment in TWHC specimens decreases with the increasing confining pressure.

  19. Testing promotes long-term learning via stabilizing activation patterns in a large network of brain areas.

    Science.gov (United States)

    Keresztes, Attila; Kaiser, Daniel; Kovács, Gyula; Racsmány, Mihály

    2014-11-01

    The testing effect refers to the phenomenon that repeated retrieval of memories promotes better long-term retention than repeated study. To investigate the neural correlates of the testing effect, we used event-related functional magnetic resonance imaging methods while participants performed a cued recall task. Prior to the neuroimaging experiment, participants learned Swahili-German word pairs, then half of the word pairs were repeatedly studied, whereas the other half were repeatedly tested. For half of the participants, the neuroimaging experiment was performed immediately after the learning phase; a 1-week retention interval was inserted for the other half of the participants. We found that a large network of areas identified in a separate 2-back functional localizer scan were active during the final recall of the word pair associations. Importantly, the learning strategy (retest or restudy) of the word pairs determined the manner in which the retention interval affected the activations within this network. Recall of previously restudied memories was accompanied by reduced activation within this network at long retention intervals, but no reduction was observed for previously retested memories. We suggest that retrieval promotes learning via stabilizing cue-related activation patterns in a network of areas usually associated with cognitive and attentional control functions. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  20. Responsiveness of the double limb lowering test and lower abdominal muscle progression to core stabilization exercise programs in healthy adults: a pilot study.

    Science.gov (United States)

    Haladay, Douglas E; Miller, Sayers J; Challis, John H; Denegar, Craig R

    2014-07-01

    Low back pain (LBP) is one of the most prevalent and expensive health care problems in the United States. Studies suggest that stabilization exercise may be effective in the management of people with LBP. To accurately assess the effect of stabilization programs on muscle performance, clinicians need an objective measure that is both valid and reliable. The purpose of this study was to determine whether the double limb lowering test (DLLT) and lower abdominal muscle progression (LAMP) can detect a change in abdominal muscle performance after stabilization exercises. Eleven healthy participants (4 men and 7 women) were randomly assigned to either a specific stabilization exercise (SSE) or general stabilization exercise (GSE) group and were evaluated by the DLLT and LAMP before, during, and at the end of 8 weeks of training. Subjects attended exercise sessions twice per week over 8 weeks. No significant difference in pretest performance existed between the 2 groups. No significant difference was detected with the DLLT for either the SSE or GSE over time or when groups were combined. The LAMP detected a significant difference for the combined groups and GSE but not SSE over time. These data indicate that the LAMP is sensitive to change after a spinal stabilization program, whereas the DLLT does not detect a change after these programs. Furthermore, the GSE was more effective in producing these changes. Additional testing of these assessments is necessary to further validate these tests and to identify specific populations for which these tests may be most appropriate.

  1. Institutional Review Boards in the University Setting: Review of Pharmaceutical Testing Protocols, Informed Consent and Ethical Concerns.

    Science.gov (United States)

    Kobasic, Dena M.

    1988-01-01

    A discussion of the testing of new drugs in campus medical facilities reviews the process of federal approval of investigational new drugs, analyzes the implications of the federally mandated institutional review board, and the issues of informed consent and the ethics of human-subject research on campus. (MSE)

  2. Genetic testing as a supporting tool in prescribing psychiatric medication: Design and protocol of the IMPACT study.

    Science.gov (United States)

    Herbert, Deanna; Neves-Pereira, Maria; Baidya, Ruth; Cheema, Sheraz; Groleau, Sarah; Shahmirian, Anashe; Tiwari, Arun K; Zai, Clement C; King, Nicole; Müller, Daniel J; Kennedy, James L

    2017-09-27

    Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, a more personalized approach is needed. This paper will discuss methods for user-friendly referrals, recruitment criteria, data storage and dissemination, biological sample and clinical questionnaire collection, and advertising. The Individualized Medicine: Pharmacogenetics Assessment and Clinical Treatment (IMPACT) study is one of the first to use pharmacogenetic testing on a large scale in psychiatry as a tool to predict individual drug response and tolerability. As IMPACT's eligibility criteria includes all diagnoses and comorbidities, the participant population will reflect the diversity amongst mental health consumers. IMPACT's innovative study design will demonstrate the utility of this testing within the health care system. IMPACT has successfully implemented pharmacogenetic testing on a relatively large scale, and in both tertiary level and primary care settings. It represents a novel approach to psychiatric care and from its initial stages the design has evolved to accommodate the nature and needs of the health care community. It is anticipated that IMPACT will continue to demonstrate the feasibility of pharmacogenetic testing and facilitate its introduction and implementation in routine healthcare practice. Copyright © 2017. Published by Elsevier Ltd.

  3. Evidence suggesting superiority of visual (verbal) vs. auditory test presentation modality in the P300-based, Complex Trial Protocol for concealed autobiographical memory detection.

    Science.gov (United States)

    Rosenfeld, J Peter; Ward, Anne; Frigo, Vincent; Drapekin, Jesse; Labkovsky, Elena

    2015-04-01

    One group of participants received a series of city name stimuli presented on trials of the Complex Trial Protocol (CTP) version of a P300-based, concealed information test (CIT). Stimuli were presented on alternating trials in either auditory or visual presentation modality. In 1/7 of the trials the participant's home town (probe) repeatedly appeared in a series of 6 other (irrelevant) repeated city names. In both modalities, probe stimuli produced larger P300s than irrelevant stimuli. Visual stimuli produced shorter behavioral reaction times and P300 latencies, as well as larger P300 probe amplitudes, probe-irrelevant amplitude differences, and individual diagnostic accuracies than the same stimuli presented in the auditory modality. Possible reasons for these effects are discussed, and subject to discussed limitations, the applied conclusion reached is that in all CITs, visual presentation of stimuli, if feasible, should be preferentially used. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Evaluation of standardized porcine bone models to test primary stability of dental implants, using biomechanical tests and Micro-CT. An in vitro pilot study

    Directory of Open Access Journals (Sweden)

    C. Delmondes Freitas Dantas

    2015-06-01

    Full Text Available Aim This study evaluated a new porcine bone model to test the primary stability of different implants, analyzing Micro-CT, insertion torque, and pull-out strength. Materials and methods Bone cylinders were prepared from porcine bone and separated into 2 groups: 10 high density bone cylinders (HDB, and 10 low density bone cylinders (LDB. Then, 3D pre-implant analyses were performed, evaluating tridimensional bone density (ratio of trabecular bone volume and total tomographic volume, BV/TV, trabecular separation; percentage of closed pores; percentage of open pores; percentage of total porosity, in 3 bone levels (L1 bone volume corresponding to the internal part of the threads; L2 corresponding to the area between 0 to 0.5 mm from the end of threads; L3 corresponding to the area between 0.5 to 1.5 mm from the end of threads. Twenty implants of two different macrostructures were inserted in the bone cylinders, and divided into 4 groups (5 implants each: Group 1, e-Fix HE implant placed in HDB cylinder; Group 2, e-Fix HE implant in LDB cylinder; Group 3, e-Fix HE Silver implant placed in HDB cylinder; Group 4, e-Fix HE Silver implant in LDB cylinder. The insertion torque was recorded and bone cylinders were re-evaluated by Micro-CT (post-implant analysis. Then a pull-out strength test was performed. Results 3D analysis showed that pre- and post-implants intra-groups evaluation had statistically significant differences in Group 3 and 4, for all tomographic parameters assessed. Group 3 showed the best values for biomechanical tests (Friedman Test, p<0.05. Conclusion This methodology can produce standardized bone cylinders of high and low bone density, in which different implant designs are able to promote different effects, evidenced by biomechanical and image analysis.

  5. Thermal stability and microstructural changes of some Ni-Cr-Mo alloys as detected by corrosion testing

    International Nuclear Information System (INIS)

    Koehler, M.; Agarwal, D.C.

    1998-01-01

    Wrought Ni-Cr-Mo alloys of the C-family show a sensitivity to intercrystalline attack especially after exposure in the temperature range of 650 C to 950 C. Nevertheless, microstructural changes due to precipitation of intermetallic phases can occur up to a temperature level of 1050 C and this can affect the localized corrosion resistance. Thermal stability of wrought Alloy C-276 is a lot lower in comparison to Alloy 59. Sensitized at 870 C for only 1 hour, Alloy C-276 fails in the ASTM-G 28 B test due to rapid intercrystalline penetration and pitting whereas Alloy 59 can be aged up to 3 hours without any increase of the corrosion rate or any pitting attack. The same ranking applies during polythermal cooling cycles. Alloy C-276 requires a cooling rate of 150 C/min. between the solution annealing temperature and 600 C to avoid any sensitization whereas for Alloy 59 a relative slow cooling rate of 25 C/min. is acceptable. The critical pitting temperature of Alloy 59 when tested in the Green Death solution had been determined to be > 125 C. The temperature was not lowered during aging up to 3 hours at 1050 C or if a cooling speed of 25 C/min. was applied. However, cooling rates of 50 C/min. or less reduced the critical pitting temperature of Alloy C-276 from 115 C in the solution annealed and water quenched condition to only 105 C

  6. Dark energy and equivalence principle constraints from astrophysical tests of the stability of the fine-structure constant

    Energy Technology Data Exchange (ETDEWEB)

    Martins, C.J.A.P.; Pinho, A.M.M.; Alves, R.F.C. [Centro de Astrofísica da Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Pino, M. [Institut Domènech i Montaner, C/Maspujols 21-23, 43206 Reus (Spain); Rocha, C.I.S.A. [Externato Ribadouro, Rua de Santa Catarina 1346, 4000-447 Porto (Portugal); Wietersheim, M. von, E-mail: Carlos.Martins@astro.up.pt, E-mail: Ana.Pinho@astro.up.pt, E-mail: up201106579@fc.up.pt, E-mail: mpc_97@yahoo.com, E-mail: cisar97@hotmail.com, E-mail: maxivonw@gmail.com [Institut Manuel Sales i Ferré, Avinguda de les Escoles 6, 43550 Ulldecona (Spain)

    2015-08-01

    Astrophysical tests of the stability of fundamental couplings, such as the fine-structure constant α, are becoming an increasingly powerful probe of new physics. Here we discuss how these measurements, combined with local atomic clock tests and Type Ia supernova and Hubble parameter data, constrain the simplest class of dynamical dark energy models where the same degree of freedom is assumed to provide both the dark energy and (through a dimensionless coupling, ζ, to the electromagnetic sector) the α variation. Specifically, current data tightly constrains a combination of ζ and the present dark energy equation of state w{sub 0}. Moreover, in these models the new degree of freedom inevitably couples to nucleons (through the α dependence of their masses) and leads to violations of the Weak Equivalence Principle. We obtain indirect bounds on the Eötvös parameter η that are typically stronger than the current direct ones. We discuss the model-dependence of our results and briefly comment on how the forthcoming generation of high-resolution ultra-stable spectrographs will enable significantly tighter constraints.

  7. Long-term reactive transport modelling of stabilized/solidified waste: from dynamic leaching tests to disposal scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Windt, Laurent de [Ecole des Mines de Paris, CG-Hydrodynamics and Reaction Group, 35 R. St-Honore, 77300 Fontainebleau (France)]. E-mail: laurent.dewindt@ensmp.fr; Badreddine, Rabia [INERIS, Direction des Risques Chroniques, Unite Dechets et Sites Pollues, Parc Technologique Alata BP 2, 60550 Verneuil-en-Halatte (France); Lagneau, Vincent [Ecole des Mines de Paris, CG-Hydrodynamics and Reaction Group, 35 R. St-Honore, 77300 Fontainebleau (France)

    2007-01-31

    Environmental impact assessment of hazardous waste disposal relies, among others, on standardized leaching tests characterized by a strong coupling between diffusion and chemical processes. In that respect, this study shows that reactive transport modelling is a useful tool to extrapolate laboratory results to site conditions characterized by lower solution/solid (L/S) ratios, site specific geometry, infiltration, etc. A cement solidified/stabilized (S/S) waste containing lead is investigated as a typical example. The reactive transport model developed in a previous study to simulate the initial state of the waste as well as laboratory batch and dynamic tests is first summarized. Using the same numerical code (HYTEC), this model is then integrated to a simplified waste disposal scenario assuming a defective cover and rain water infiltration. The coupled evolution of the S/S waste chemistry and the pollutant plume migration are modelled assessing the importance of the cracking state of the monolithic waste. The studied configurations correspond to an undamaged and fully sealed system, a few main fractures between undamaged monoliths and, finally, a dense crack-network in the monoliths. The model considers the potential effects of cracking, first the increase of rain water and carbon dioxide infiltration and, secondly, the increase of L/S ratio and reactive surfaces, using either explicit fracture representation or dual porosity approaches.

  8. ANNALS EXPRESS: Evaluation of sample stability for a quantitative faecal immunochemical test and comparison of two sample collection approaches.

    Science.gov (United States)

    Mellen, Samantha; de Ferrars, Maria; Chapman, Claire Louise; Bevan, Sarah; Turvill, James; Turnock, Daniel Charles

    2018-01-01

    Faecal immunochemical testing (FIT) is increasingly being used to triage symptomatic patients for suspected colorectal cancer. However, there are limited data on the effect of pre-analytical factors on faecal haemoglobin (f-Hb) when measured by FIT. The aim of this work was to evaluate the stability of f-Hb in faeces and to compare two methods of f-Hb sampling for FIT. Six patients provided faeces for f-Hb measurement which were transferred into specialised collection devices at baseline and at 1, 2, 3 and 7 days after storage at either room temperature or 4°C. A total of 137 patients returned both faeces transferred into the specialised collection device and faeces in a standard collection pot. A quantitative immunoturbidometric method was used to measure f-Hb and results were compared categorically. Discrepant results were assessed against diagnosis. f-Hb concentration declined rapidly within a day of storage at room temperature but results remained ⩾10 µg Hb/ g faeces in 5/6 patients after two days. An f-Hb result ⩾10 µg Hb/ g faeces was obtained in 4/6 patients after storage for seven days at 4⁰C. Results obtained when patients used specialised collection devices were significantly different to results obtained when faeces was transferred into the specialised collection device in the laboratory. There is considerable heterogeneity in f-Hb sample stability therefore samples should be transferred rapidly into specialised collection devices to prevent false negative results. Use of collection devices by patients can lead to false positive results compared to their use in a laboratory.

  9. Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study.

    Science.gov (United States)

    Geber, Christian; Klein, Thomas; Azad, Shahnaz; Birklein, Frank; Gierthmühlen, Janne; Huge, Volker; Lauchart, Meike; Nitzsche, Dorothee; Stengel, Maike; Valet, Michael; Baron, Ralf; Maier, Christoph; Tölle, Thomas; Treede, Rolf-Detlef

    2011-03-01

    Quantitative sensory testing (QST) is an instrument to assess positive and negative sensory signs, helping to identify mechanisms underlying pathologic pain conditions. In this study, we evaluated the test-retest reliability (TR-R) and the interobserver reliability (IO-R) of QST in patients with sensory disturbances of different etiologies. In 4 centres, 60 patients (37 male and 23 female, 56.4±1.9years) with lesions or diseases of the somatosensory system were included. QST comprised 13 parameters including detection and pain thresholds for thermal and mechanical stimuli. QST was performed in the clinically most affected test area and a less or unaffected control area in a morning and an afternoon session on 2 consecutive days by examiner pairs (4 QSTs/patient). For both, TR-R and IO-R, there were high correlations (r=0.80-0.93) at the affected test area, except for wind-up ratio (TR-R: r=0.67; IO-R: r=0.56) and paradoxical heat sensations (TR-R: r=0.35; IO-R: r=0.44). Mean IO-R (r=0.83, 31% unexplained variance) was slightly lower than TR-R (r=0.86, 26% unexplained variance, Ptest area (TR-R: r=0.86; IO-R: r=0.83) than in the control area (TR-R: r=0.79; IO-R: r=0.71, each Ptest-retest and interobserver reliability within 2days. With standardized training, observer bias is much lower than random variance. Quantitative sensory testing performed by trained examiners is a valuable diagnostic instrument with good interobserver and test-retest reliability for use in patients with sensory disturbances of different etiologies to help identify mechanisms of neuropathic and non-neuropathic pain. Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  10. Project Stronger Together: Protocol to Test a Dyadic Intervention to Improve Engagement in HIV Care Among Sero-Discordant Male Couples in Three US Cities.

    Science.gov (United States)

    Stephenson, Rob; Suarez, Nicolas A; Garofalo, Robert; Hidalgo, Marco A; Hoehnle, Samuel; Thai, Jennie; Mimiaga, Matthew J; Brown, Emily; Bratcher, Anna; Wimbly, Taylor; Sullivan, Patrick

    2017-08-31

    An estimated one- to-two-thirds of new human immunodeficiency virus (HIV) infections among US men who have sex with men (MSM) occur within the context of primary partnerships. Despite this fact, there remains a lack of prevention interventions that focus on male sero-discordant dyads. Interventions that provide male couples with skills to manage HIV risk, and to support each other towards active engagement in HIV prevention and care, are urgently needed. The objective of this paper is to describe the protocol for an innovative dyadic intervention (Stronger Together) that combines couples' HIV testing and dyadic adherence counseling to improve treatment adherence and engagement in care among HIV sero-discordant male couples in the United States. The research activities involve a prospective randomized controlled trial (RCT) of approximately 165 venue- and clinic-recruited sero-discordant male couples (330 individuals: 165 HIV sero-negative and 165 HIV sero-positive). Couples randomized into the intervention arm receive couples' HIV counseling and testing plus dyadic adherence counseling, while those randomized to the control arm receive individual HIV counseling and testing. The study takes place in three cities: Atlanta, GA (study site Emory University); Boston, MA (study site The Fenway Institute); and Chicago, IL (study site Ann & Robert H. Lurie Children's Hospital of Chicago). Cohort recruitment began in 2015. Couples are followed prospectively for 24 months, with study assessments at baseline, 6, 12, 18, and 24 months. Stronger Together was launched in August 2014. To date, 160 couples (97% of the target enrollment) have been enrolled and randomized. The average retention rate across the three sites is 95%. Relationship dissolution has been relatively low, with only 13 couples breaking up during the RCT. Of the 13 couples who have broken up, 10 of the 13 HIV-positive partners have been retained in the cohort; none of these HIV-positive partners have enrolled

  11. Developing and user-testing Decision boxes to facilitate shared decision making in primary care - a study protocol

    Directory of Open Access Journals (Sweden)

    Rousseau François

    2011-03-01

    Full Text Available Abstract Background Applying evidence is one of the most challenging steps of evidence-based clinical practice. Healthcare professionals have difficulty interpreting evidence and translating it to patients. Decision boxes are summaries of the most important benefits and harms of diagnostic, therapeutic, and preventive health interventions provided to healthcare professionals before they meet the patient. Our hypothesis is that Decision boxes will prepare clinicians to help patients make informed value-based decisions. By acting as primers, the boxes will enhance the application of evidence-based practices and increase shared decision making during the clinical encounter. The objectives of this study are to provide a framework for developing Decision boxes and testing their value to users. Methods/Design We will begin by developing Decision box prototypes for 10 clinical conditions or topics based on a review of the research on risk communication. We will present two prototypes to purposeful samples of 16 family physicians distributed in two focus groups, and 32 patients distributed in four focus groups. We will use the User Experience Model framework to explore users' perceptions of the content and format of each prototype. All discussions will be transcribed, and two researchers will independently perform a hybrid deductive/inductive thematic qualitative analysis of the data. The coding scheme will be developed a priori from the User Experience Model's seven themes (valuable, usable, credible, useful, desirable, accessible and findable, and will include new themes suggested by the data (inductive analysis. Key findings will be triangulated using additional publications on the design of tools to improve risk communication. All 10 Decision boxes will be modified in light of our findings. Discussion This study will produce a robust framework for developing and testing Decision boxes that will serve healthcare professionals and patients alike. It

  12. Protocol for population testing of an Internet-based Personalised Decision Support system for colorectal cancer screening

    Directory of Open Access Journals (Sweden)

    Wilson Carlene J

    2010-09-01

    Full Text Available Abstract Background Australia has a comparatively high incidence of colorectal (bowel cancer; however, population screening uptake using faecal occult blood test (FOBT remains low. This study will determine the impact on screening participation of a novel, Internet-based Personalised Decision Support (PDS package. The PDS is designed to measure attitudes and cognitive concerns and provide people with individually tailored information, in real time, that will assist them with making a decision to screen. The hypothesis is that exposure to (tailored PDS will result in greater participation in screening than participation following exposure to non-tailored PDS or resulting from the current non-tailored, paper-based approach. Methods/design A randomised parallel trial comprising three arms will be conducted. Men and women aged 50-74 years (N = 3240 will be recruited. They must have access to the Internet; have not had an FOBT within the previous 12 months, or sigmoidoscopy or colonoscopy within the previous 5 years; have had no clinical diagnosis of bowel cancer. Groups 1 and 2 (PDS arms will access a website and complete a baseline survey measuring decision-to-screen stage, attitudes and cognitive concerns and will receive immediate feedback; Group 1 will receive information 'tailored' to their responses in the baseline survey and group 2 will received 'non-tailored' bowel cancer information. Respondents in both groups will subsequently receive an FOBT kit. Group 3 (usual practice arm will complete a paper-based version of the baseline survey and respondents will subsequently receive 'non-tailored' paper-based bowel cancer information with accompanying FOBT kit. Following despatch of FOBTs, all respondents will be requested to complete an endpoint survey. Main outcome measures are (1 completion of FOBT and (2 change in decision-to-screen stage. Secondary outcomes include satisfaction with decision and change in attitudinal scores from baseline to

  13. Testing the leadership and organizational change for implementation (LOCI) intervention in substance abuse treatment: a cluster randomized trial study protocol.

    Science.gov (United States)

    Aarons, Gregory A; Ehrhart, Mark G; Moullin, Joanna C; Torres, Elisa M; Green, Amy E

    2017-03-03

    Evidence-based practice (EBP) implementation represents a strategic change in organizations that requires effective leadership and alignment of leadership and organizational support across organizational levels. As such, there is a need for combining leadership development with organizational strategies to support organizational climate conducive to EBP implementation. The leadership and organizational change for implementation (LOCI) intervention includes leadership training for workgroup leaders, ongoing implementation leadership coaching, 360° assessment, and strategic planning with top and middle management regarding how they can support workgroup leaders in developing a positive EBP implementation climate. This test of the LOCI intervention will take place in conjunction with the implementation of motivational interviewing (MI) in 60 substance use disorder treatment programs in California, USA. Participants will include agency executives, 60 program leaders, and approximately 360 treatment staff. LOCI will be tested using a multiple cohort, cluster randomized trial that randomizes workgroups (i.e., programs) within agency to either LOCI or a webinar leadership training control condition in three consecutive cohorts. The LOCI intervention is 12 months, and the webinar control intervention takes place in months 1, 5, and 8, for each cohort. Web-based surveys of staff and supervisors will be used to collect data on leadership, implementation climate, provider attitudes, and citizenship. Audio recordings of counseling sessions will be coded for MI fidelity. The unit of analysis will be the workgroup, randomized by site within agency and with care taken that co-located workgroups are assigned to the same condition to avoid contamination. Hierarchical linear modeling (HLM) will be used to analyze the data to account for the nested data structure. LOCI has been developed to be a feasible and effective approach for organizations to create a positive climate and

  14. Comparison of mailed invitation strategies to improve fecal occult blood test participation in men: protocol for a randomized controlled trial.

    Science.gov (United States)

    Duncan, Amy; Zajac, Ian; Flight, Ingrid; Stewart, Benjamin J R; Wilson, Carlene; Turnbull, Deborah

    2013-07-31

    Men have a significantly increased risk of being diagnosed with, and dying from, colorectal cancer (CRC) than women. Men also participate in fecal occult blood test (FOBT) screening at a lower rate than women. This study will determine whether strategies that target men's attitudes toward screening, and matched to stage of readiness to screen, increase men's FOBT participation compared to a standard approach. Eligible trial participants will be a national sample of 9,200 men aged 50 to 74 years, living in urban Australia and randomly selected from the Australian electoral roll. Trial participants will be mailed an advance notification letter, followed 2 weeks later by an invitation letter and a free fecal immunochemical test (FIT) kit. The intervention is a factorial design, randomized controlled trial (RCT) with four trial arms, including a control. The content of the advance notification and invitation letters will differ by trial arm as follows: 1) standard advance notification and standard invitation (control arm); 2) targeted advance notification and standard invitation; 3) standard advance notification and targeted invitation; and 4) targeted advance notification and targeted invitation. The standard letters will replicate as closely as possible the letters included in the Australian National Bowel Cancer Screening Program (NBCSP). Modified advance notification and invitation letters will incorporate additional messages to target men in the precontemplation (advance notification) and contemplation stages (invitation). The primary outcome is return of the completed FIT within 12 weeks of invitation. Analysts will be blinded to trial assignment and participants will be blinded to the use of varying invitational materials. Subsamples from each trial arm will complete baseline and endpoint surveys to measure the psychological impact of the intervention, and qualitative interviews will be conducted to evaluate attitudes toward the intervention. The outcomes of

  15. Testing the START Triage Protocol: Can It Improve the Ability of Nonmedical Personnel to Better Triage Patients During Disasters and Mass Casualties Incidents ?

    Science.gov (United States)

    Badiali, Stefano; Giugni, Aimone; Marcis, Lucia

    2017-06-01

    START (Simple Triage and Rapid Treatment) triage is a tool that is available even to nonmedical rescue personnel in case of a disaster or mass casualty incident (MCI). In Italy, no data are available on whether application of the START protocol could improve patient outcomes during a disaster or MCI. We aimed to address whether "last-minute" START training of nonmedical personnel during a disaster or MCI would result in more effective triage of patients. In this case-control study, 400 nonmedical ambulance crew members were randomly assigned to a non-START or a START group (200 per group). The START group received last-minute START training. Each group examined 6000 patients, obtained from the Emergo Train System (ETS Italy, Bologna, Italy) victims database, and assigned patients a triage code (black-red-yellow-green) along with a reason for the assignment. Each rescuer triaged 30 patients within a 30-minute time frame. Results were analyzed according to Fisher's exact test for a P valueSTART group completed the evaluations in 15 minutes, whereas the non-START group took 30 minutes. The START group correctly triaged 94.2% of their patients, as opposed to 59.83% of the non-START group (PSTART group versus 13.67% and 26.5% for the non-START group. The non-START group had 458 "preventable deaths" on 6000 cases because of incorrect triage, whereas the START group had 91. Even a "last-minute" training on the START triage protocol allows nonmedical personnel to better identify and triage the victims of a disaster or MCI, resulting in more effective and efficient medical intervention. (Disaster Med Public Health Preparedness. 2017;11:305-309).

  16. Pilot testing and protocol development of giant applesnail suppression at Mandalay National Wildlife Refuge, Louisiana—July–October 2017

    Science.gov (United States)

    Carter, Jacoby; Merino, Sergio

    2018-03-19

    This report provides an overview of the pilot study and description of the techniques developed for a future mitigation study of Pomacea maculata (giant applesnail) at the U.S. Fish and Wildlife Service Mandalay National Wildlife Refuge, Louisiana (MNWR). Egg mass suppression is a potential strategy for the mitigation of the invasive giant applesnail. In previous studies at Langan Municipal Park in Mobile, Alabama (LMP), and National Park Service Jean Lafitte National Park-Barataria Unit, Louisiana (JLNP), we determined that spraying food-grade oil (coconut oil or Pam™ spray) on egg masses significantly reduced egg hatching. At JLNP we also developed methods to estimate snail population size. The purpose of this pilot study was to adapt techniques developed for previous studies to the circumstances of MNWR in preparation for a larger experiment whereby we will test the effectiveness of egg mass suppression as an applesnail mitigation tool. We selected four canals that will be used as treatment and control sites for the experiment (two each). We established that an efficient way to destroy egg masses is to knock them down with a high-velocity stream of water pumped directly from the canal. The traps used at JLNP had to be modified to accommodate the greater range of water-level fluctuation at MNWR. One of the three marking methods used at JLNP was selected for use at MNWR.

  17. Performance, Facility Pressure Effects, and Stability Characterization Tests of NASA's Hall Effect Rocket with Magnetic Shielding Thruster

    Science.gov (United States)

    Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Yim, John; Herman, Daniel; Peterson, Peter Y.; Williams, George J.; Gilland, James; Hofer, Richard; Mikellides, Ioannis

    2016-01-01

    NASA's Hall Effect Rocket with Magnetic Shielding (HERMeS) 12.5 kW Technology Demonstration Unit-1 (TDU-1) has been the subject of extensive technology maturation in preparation for flight system development. Part of the technology maturation effort included experimental evaluation of the TDU-1 thruster with conducting and dielectric front pole cover materials in two different electrical configurations. A graphite front magnetic pole cover thruster configuration with the thruster body electrically tied to cathode, and an alumina front pole cover thruster configuration with the thruster body floating were evaluated. Both configurations were also evaluated at different facility background pressure conditions to evaluate background pressure effects on thruster operation. Performance characterization tests found that higher thruster performance was attained with the graphite front pole cover configuration with the thruster electrically tied to cathode. A total thrust efficiency of 68% and a total specific impulse of 2,820 s was demonstrated at a discharge voltage of 600 V and a discharge power of 12.5 kW. Thruster stability regimes were characterized with respect to the thruster discharge current oscillations and with maps of the discharge current-voltage-magnetic field (IVB). Analysis of TDU-1 discharge current waveforms found that lower normalized discharge current peak-to-peak and root mean square magnitudes were attained when the thruster was electrically floated with alumina front pole covers. Background pressure effects characterization tests indicated that the thruster performance and stability were mostly invariant to changes in the facility background pressure for vacuum chamber pressure below 1×10-5 Torr-Xe (for thruster flow rates of 20.5 mg/s). Power spectral density analysis of the discharge current waveforms showed that increasing the vacuum chamber background pressure resulted in a higher discharge current dominant breathing mode frequency. Finally, IVB

  18. Performance, Facility Pressure Effects, and Stability Characterization Tests of NASA's Hall Effect Rocket with Magnetic Shielding Thruster

    Science.gov (United States)

    Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Yim, John; Herman, Daniel; Williams, George; Gilland, James; Peterson, Peter; Hofer, Richard; Mikellides, Ioannis

    2016-01-01

    NASAs Hall Effect Rocket with Magnetic Shielding (HERMeS) 12.5 kW Technology Demonstration Unit-1 (TDU-1) Hall thruster has been the subject of extensive technology maturation in preparation for flight system development. Part of the technology maturation effort included experimental evaluation of the TDU-1 thruster with conducting and dielectric front pole cover materials in two different electrical configurations. A graphite front pole cover thruster configuration with the thruster body electrically tied to cathode and an alumina front pole cover thruster configuration with the thruster body floating were evaluated. Both configurations were also evaluated at different facility background pressure conditions to evaluate background pressure effects on thruster operation. Performance characterization tests found that higher thruster performance was attained with the graphite front pole cover configuration with the thruster electrically tied to cathode. A total thrust efficiency of 68 and a total specific impulse of 2,820 s was demonstrated at a discharge voltage of 600 V and a discharge power of 12.5 kW. Thruster stability regimes were characterized with respect to the thruster discharge current oscillations and with maps of the current-voltage-magnetic field (IVB). Analysis of TDU-1 discharge current waveforms found that lower normalized discharge current peak-to-peak and root mean square magnitudes were attained when the thruster was electrically floated with alumina front pole covers. Background pressure effects characterization tests indicated that the thruster performance and stability was mostly invariant to changes in the facility background pressure for vacuum chamber pressure below 110-5 Torr-Xe (for thruster flow rate above 8 mgs). Power spectral density analysis of the discharge current waveform showed that increasing the vacuum chamber background pressure resulted in a higher discharge current dominant frequency. Finally the IVB maps of the TDU-1

  19. High-Yield HIV Testing, Facilitated Linkage to Care, and Prevention for Female Youth in Kenya (GIRLS Study): Implementation Science Protocol for a Priority Population.

    Science.gov (United States)

    Inwani, Irene; Chhun, Nok; Agot, Kawango; Cleland, Charles M; Buttolph, Jasmine; Thirumurthy, Harsha; Kurth, Ann E

    2017-12-13

    Sub-Saharan Africa is the region with the highest HIV burden. Adolescent girls and young women (AGYW) in the age range of 15 to 24 years are twice as likely as their male peers to be infected, making females in sub-Saharan Africa the most at-risk group for HIV infection. It is therefore critical to prioritize access to HIV testing, prevention, and treatment for this vulnerable population. Using an implementation science framework, the purpose of this research protocol was to describe the approaches we propose to optimize engagement of AGYW in both the HIV prevention and care continuum and to determine the recruitment and testing strategies that identify the highest proportion of previously undiagnosed HIV infections. We will compare two seek recruitment strategies, three test strategies, and pilot adaptive linkage to care interventions (sequential multiple assignment randomized trial [SMART] design) among AGYW in the age range of 15 to 24 years in Homa Bay County, western Kenya. AGYW will be recruited in the home or community-based setting and offered three testing options: oral fluid HIV self-testing, staff-aided rapid HIV testing, or referral to a health care facility for standard HIV testing services. Newly diagnosed AGYW with HIV will be enrolled in the SMART trial pilot to determine the most effective way to support initial linkage to care after a positive diagnosis. They will be randomized to standard referral (counseling and a referral note) or standard referral plus SMS text message (short message service, SMS); those not linked to care within 2 weeks will be rerandomized to receive an additional SMS text message or a one-time financial incentive (approximately US $4). We will also evaluate a primary prevention messaging intervention to support identified high-risk HIV-negative AGYW to reduce their HIV risk and adhere to HIV retesting recommendations. We will also conduct analyses to determine the incremental cost-effectiveness of the seek, testing and

  20. Study protocol: a randomised controlled trial testing the effectiveness of 'Op Volle Kracht' in Dutch residential care.

    Science.gov (United States)

    Weeland, Martine M; Nijhof, Karin S; Vermaes, Ignace; Engels, Rutger C M E; Buitelaar, Jan K

    2015-07-21

    Although adolescents are often referred to residential treatment centres because of severe externalizing behaviours, a vast majority demonstrated comorbid symptoms of depression and anxiety. Covert internalizing symptoms in these adolescents might be easily unrecognized and therefore untreated. Adolescents with mild intellectual disability (MID) are overrepresented among youth with both externalizing and internalizing problems. There are yet few treatment programs available for adolescents with both externalizing and internalizing problems. The CBT-based resiliency program, Op Volle Kracht (OVK), which is based on the US Penn Resiliency Program (PRP), was adapted to suit the needs of adolescents with both externalizing and internalizing problems, either with or without MID, in Dutch residential treatment centres. The effectiveness of this group intervention program of eight sessions will be tested in a randomised controlled trial (RCT) with N = 182 adolescents aged 12-16, allocated to either the target intervention plus treatment as usual (OVK + TAU) or treatment as usual only (TAU). The main outcome variables include depressive symptoms (primary), anxiety, behavioural problems, and group therapeutic climate. Cognitive styles and coping styles will be included as possible mediators. Assessments take place at baseline (T1), one week before the start of the program (T2), immediately after the program (T3), and at three months follow-up (T4). The program assets include its wide implementation possibilities due to low costs, the short duration of the program and the delivery by group care workers, and its suitability for adolescents with MID. Further strengths of the present study design include its robust method (RCT), the ecological validity, and the inclusion of possible mediators of treatment effect. The program emphasizes individual risk factors for depression rather than social and family factors. Implications for practice and future research are

  1. Immunochemical protocols

    National Research Council Canada - National Science Library

    Pound, John D

    1998-01-01

    ... easy and important refinements often are not published. This much anticipated 2nd edition of Immunochemzcal Protocols therefore aims to provide a user-friendly up-to-date handbook of reliable techniques selected to suit the needs of molecular biologists. It covers the full breadth of the relevant established immunochemical methods, from protein blotting and immunoa...

  2. Testing use of payers to facilitate evidence-based practice adoption: protocol for a cluster-randomized trial.

    Science.gov (United States)

    Molfenter, Todd; Kim, Jee-Seon; Quanbeck, Andrew; Patel-Porter, Terry; Starr, Sandy; McCarty, Dennis

    2013-05-10

    investigates the role of payers in evidence-based practice implementation using a randomized controlled design instead of case examples. The testing of the Advancing Recovery Framework is designed to broaden the understanding of the impact payers have on evidence-based practice (EBP) adoption. http://NCT01702142 (ClinicalTrials.gov registry, USA).

  3. Test of a workforce development intervention to expand opioid use disorder treatment pharmacotherapy prescribers: protocol for a cluster randomized trial.

    Science.gov (United States)

    Molfenter, Todd; Knudsen, Hannah K; Brown, Randy; Jacobson, Nora; Horst, Julie; Van Etten, Mark; Kim, Jee-Seon; Haram, Eric; Collier, Elizabeth; Starr, Sanford; Toy, Alexander; Madden, Lynn

    2017-11-15

    Overdoses due to non-medical use of prescription opioids and other opiates have become the leading cause of accidental deaths in the USA. Buprenorphine and extended-release naltrexone are key evidence-based pharmacotherapies available to addiction treatment providers to address opioid use disorder (OUD) and prevent overdose deaths. Treatment organizations' efforts to provide these pharmacotherapies have, however, been stymied by limited success in recruiting providers (physicians, nurse practitioners, and physician assistants) to prescribe these medications. Historically, the addiction treatment field has not attracted physicians, and many barriers to implementing OUD pharmacotherapy exist, ranging from lack of confidence in treating OUD patients to concerns regarding reimbursement. Throughout the USA, the prevalence of OUD far exceeds the capacity of the OUD pharmacotherapy treatment system. Poor access to OUD pharmacotherapy prescribers has become a workforce development need for the addiction treatment field and a significant health issue. This cluster randomized controlled trial (RCT) is designed to increase buprenorphine and extended-release naltrexone treatment capacity for OUD. The implementation intervention to be tested is a bundle of OUD pharmacotherapy capacity building practices called the Prescriber Recruitment Bundle (PRB), which was developed and piloted in a previous statewide buprenorphine implementation study. For this cluster RCT, organizational sites will be recruited and then randomized into one of two arms: (1) control, with treatment as usual and access to a website with PRB resources, or (2) intervention, with organizations implementing the PRB using the Network for the Improvement of Addiction Treatment organizational change model over a 24-month intervention period and a 10-month sustainability period. The primary treatment outcomes for each organizational site are self-reported monthly counts of buprenorphine slots, extended

  4. Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN): study protocol for a randomised controlled trial.

    Science.gov (United States)

    Wilkinson, Esther L; O'Mahen, Heather A; Fearon, Pasco; Halligan, Sarah; King, Dorothy X; Greenfield, Geva; Dunkley-Bent, Jacqueline; Ericksen, Jennifer; Milgrom, Jeannette; Ramchandani, Paul G

    2016-03-22

    National guidelines in the UK, United States of America, Canada, and Australia have recently stressed the importance of identifying and treating antenatal anxiety and depression. However, there is little research into the most effective and acceptable ways of helping women manage their symptoms of anxiety and stress during pregnancy. Research indicates the necessity to consider the unique needs and concerns of perinatal populations to ensure treatment engagement, highlighting the need to develop specialised treatments which could be integrated within routine antenatal healthcare services. This trial aims to develop a brief intervention for antenatal anxiety, with a focus on embedding the delivery of the treatment within routine antenatal care. This study is a two-phase feasibility trial. In phase 1 we will develop and pilot a brief intervention for antenatal anxiety, blended with group support, to be led by midwives. This intervention will draw on cognitive behavioural principles and wider learning from existing interventions that have been used to reduce anxiety in expectant mothers. The intervention will then be tested in a pilot randomised controlled trial in phase 2. The following outcomes will be assessed: (1) number of participants meeting eligibility criteria, (2) number of participants consenting to the study, (3) number of participants randomised, (4) number of sessions completed by those in the intervention arm, and (5) number of participants completing the post-intervention outcome measures. Secondary outcomes comprise: detailed feedback on acceptability, which will guide further development of the intervention; and outcome data on symptoms of maternal and paternal anxiety and depression, maternal quality of life, quality of couple relationship, mother-child bonding, infant temperament and infant sleep. The study will provide important data to inform the design of a future full-scale randomised controlled trial of a brief intervention for anxiety during

  5. A 12-Week Vigorous Exercise Protocol in a Healthy Group of Persons over 65: Study of Physical Function by means of the Senior Fitness Test.

    Science.gov (United States)

    Todde, Francesco; Melis, Franco; Mura, Roberto; Pau, Massimiliano; Fois, Francesco; Magnani, Sara; Ibba, Gianfranco; Crisafulli, Antonio; Tocco, Filippo

    2016-01-01

    The aim of this study was to assess the effects of vigorous exercise on functional abilities by means of a Senior Fitness Test (SFT) in a group of elderly adults. Twenty healthy and inactive people performed vigorous exercise (VE: 12 men and 8 women, aged 69.6 ± 3.9 years). At the beginning of the study (T0) and after 3 months (T1), each subject's functional ability was tested for muscular strength, agility, cardiovascular fitness, flexibility, and balance. The VE was designed with continuous and interval exercise involving large muscle activities. Functional exercises were performed between 60% and 84% of heart rate reserve (HRR) for a duration of 65 minutes. Five out of the 6 SFTs performed were found significantly improved: Chair Stand (T0 12.4 ± 2.4, T1 13.5 ± 2.6, p Sit-and-Reach (T0 -9.9 ± 7.7 cm, T1 1.7 ± 6.3 cm, p < 0.01), and Back Scratch (T0 -15.8 ± 10.9 cm, T1 -8.4 ± 13.1 cm, p < 0.01). Our results suggest that a high intensity protocol and functional exercises can improve functional mobility and muscle endurance in those over 65 years of age. SFTs are an effective method for assessing improvements in the functional capacity of elderly adults.

  6. Number of test trials needed for performance stability and interrater reliability of the one leg stand test in patients with a major non-traumatic lower limb amputation.

    Science.gov (United States)

    Kristensen, Morten Tange; Nielsen, Anni Østergaard; Topp, Ulla Madsen; Jakobsen, Berit; Nielsen, Kirsten Juel; Juul-Larsen, Helle Gybel; Jakobsen, Thomas Linding

    2014-01-01

    Balance is beneficial for daily functioning of patients with a lower limb amputation and sometimes assessed by the one-leg stand test (OLST). The aims of the study were to examine (1) the number of trials needed to achieve performance stability, (2) the interrater reliability of the OLST in patients with a major non-traumatic lower limb amputation, and (3) to provide a test procedure. Thirteen women and 23 men with a mean age (SD) of 67.4 (10.6) years; 19 below-knee and 17 above-knee amputees who performed the OLST at a mean of 14.5 (4.5) days post-amputation. All patients performed five timed OLST-trials with 1-min rest intervals between trials, supervised by a physical therapist, of which 28 included in the reliability-part conducted this twice, separated with a mean of 3.4 (0.78)h. Repeated measures Friedman determined the number of trials needed to ensure stable OLST-scores while the ICC1.1, the standard error of measurement (SEM) and the smallest real difference (SRD) determined reproducibility. No learning curve was found for the five OLST-trials (p=0.241), with the best of the five trials reaching a median (25-75% quartile) of 2.9 (1.7-8.2)s, and with only six patients able to stand for more than 10s. The ICC (95% CI), SEM and SRD were respectively 0.87 (0.61-0.96), 0.99 s and 2.74 s. Findings suggest that the best of five trials be used for the OLST in unilateral non-traumatic amputee patients as we found excellent interrater reliability and acceptable agreement when using this score. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Determination of Hydrogen Bond Structure in Water versus Aprotic Environments To Test the Relationship Between Length and Stability.

    Science.gov (United States)

    Sigala, Paul A; Ruben, Eliza A; Liu, Corey W; Piccoli, Paula M B; Hohenstein, Edward G; Martínez, Todd J; Schultz, Arthur J; Herschlag, Daniel

    2015-05-06

    Hydrogen bonds profoundly influence the architecture and activity of biological macromolecules. Deep appreciation of hydrogen bond contributions to biomolecular function thus requires a detailed understanding of hydrogen bond structure and energetics and the relationship between these properties. Hydrogen bond formation energies (ΔGf) are enormously more favorable in aprotic solvents than in water, and two classes of contributing factors have been proposed to explain this energetic difference, focusing respectively on the isolated and hydrogen-bonded species: (I) water stabilizes the dissociated donor and acceptor groups much better than aprotic solvents, thereby reducing the driving force for hydrogen bond formation; and (II) water lengthens hydrogen bonds compared to aprotic environments, thereby decreasing the potential energy within the hydrogen bond. Each model has been proposed to provide a dominant contribution to ΔGf, but incisive tests that distinguish the importance of these contributions are lacking. Here we directly test the structural basis of model II. Neutron crystallography, NMR spectroscopy, and quantum mechanical calculations demonstrate that O-H···O hydrogen bonds in crystals, chloroform, acetone, and water have nearly identical lengths and very similar potential energy surfaces despite ΔGf differences >8 kcal/mol across these solvents. These results rule out a substantial contribution from solvent-dependent differences in hydrogen bond structure and potential energy after association (model II) and thus support the conclusion that differences in hydrogen bond ΔGf are predominantly determined by solvent interactions with the dissociated groups (model I). These findings advance our understanding of universal hydrogen-bonding interactions and have important implications for biology and engineering.

  8. Stability of CIGS Solar Cells and Component Materials Evaluated by a Step-Stress Accelerated Degradation Test Method: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Pern, F. J.; Noufi, R.

    2012-10-01

    A step-stress accelerated degradation testing (SSADT) method was employed for the first time to evaluate the stability of CuInGaSe2 (CIGS) solar cells and device component materials in four Al-framed test structures encapsulated with an edge sealant and three kinds of backsheet or moisture barrier film for moisture ingress control. The SSADT exposure used a 15oC and then a 15% relative humidity (RH) increment step, beginning from 40oC/40%RH (T/RH = 40/40) to 85oC/70%RH (85/70) as of the moment. The voluminous data acquired and processed as of total DH = 3956 h with 85/70 = 704 h produced the following results. The best CIGS solar cells in sample Set-1 with a moisture-permeable TPT backsheet showed essentially identical I-V degradation trend regardless of the Al-doped ZnO (AZO) layer thickness ranging from standard 0.12 μm to 0.50 μm on the cells. No clear 'stepwise' feature in the I-V parameter degradation curves corresponding to the SSADT T/RH/time profile was observed. Irregularity in I-V performance degradation pattern was observed with some cells showing early degradation at low T/RH < 55/55 and some showing large Voc, FF, and efficiency degradation due to increased series Rs (ohm-cm2) at T/RH ≥ 70/70. Results of (electrochemical) impedance spectroscopy (ECIS) analysis indicate degradation of the CIGS solar cells corresponded to increased series resistance Rs (ohm) and degraded parallel (minority carrier diffusion/recombination) resistance Rp, capacitance C, overall time constant Rp*C, and 'capacitor quality' factor (CPE-P), which were related to the cells? p-n junction properties. Heating at 85/70 appeared to benefit the CIGS solar cells as indicated by the largely recovered CPE-P factor. Device component materials, Mo on soda lime glass (Mo/SLG), bilayer ZnO (BZO), AlNi grid contact, and CdS/CIGS/Mo/SLG in test structures with TPT showed notable to significant degradation at T/RH ≥ 70/70. At T/RH = 85/70, substantial blistering of

  9. A mixed methods protocol for developing and testing implementation strategies for evidence-based obesity prevention in childcare: a cluster randomized hybrid type III trial.

    Science.gov (United States)

    Swindle, Taren; Johnson, Susan L; Whiteside-Mansell, Leanne; Curran, Geoffrey M

    2017-07-18

    Despite the potential to reach at-risk children in childcare, there is a significant gap between current practices and evidence-based obesity prevention in this setting. There are few investigations of the impact of implementation strategies on the uptake of evidence-based practices (EBPs) for obesity prevention and nutrition promotion. This study protocol describes a three-phase approach to developing and testing implementation strategies to support uptake of EBPs for obesity prevention practices in childcare (i.e., key components of the WISE intervention). Informed by the i-PARIHS framework, we will use a stakeholder-driven evidence-based quality improvement (EBQI) process to apply information gathered in qualitative interviews on barriers and facilitators to practice to inform the design of implementation strategies. Then, a Hybrid Type III cluster randomized trial will compare a basic implementation strategy (i.e., intervention as usual) with an enhanced implementation strategy informed by stakeholders. All Head Start centers (N = 12) within one agency in an urban area in a southern state in the USA will be randomized to receive the basic or enhanced implementation with approximately 20 classrooms per group (40 educators, 400 children per group). The educators involved in the study, the data collectors, and the biostastician will be blinded to the study condition. The basic and enhanced implementation strategies will be compared on outcomes specified by the RE-AIM model (e.g., Reach to families, Effectiveness of impact on child diet and health indicators, Adoption commitment of agency, Implementation fidelity and acceptability, and Maintenance after 6 months). Principles of formative evaluation will be used throughout the hybrid trial. This study will test a stakeholder-driven approach to improve implementation, fidelity, and maintenance of EBPs for obesity prevention in childcare. Further, this study provides an example of a systematic process to develop

  10. Implementing an Internet-Delivered Skin Cancer Genetic Testing Intervention to Improve Sun Protection Behavior in a Diverse Population: Protocol for a Randomized Controlled Trial.

    Science.gov (United States)

    Hay, Jennifer L; Berwick, Marianne; Zielaskowski, Kate; White, Kirsten Am; Rodríguez, Vivian M; Robers, Erika; Guest, Dolores D; Sussman, Andrew; Talamantes, Yvonne; Schwartz, Matthew R; Greb, Jennie; Bigney, Jessica; Kaphingst, Kimberly A; Hunley, Keith; Buller, David B

    2017-04-25

    average-risk personalized genomic testing for melanoma risk findings, and examine predictors of sun protection at 3 months as the outcome. These findings will be used to develop messages for groups that receive average-risk feedback. Aim 2 will compare rates of test consideration in Hispanics versus non-Hispanics, including consideration of testing pros and cons and registration of a decision to either accept or decline testing. Aim 3 will examine personalized genomic testing for melanoma risk feedback comprehension, recall, satisfaction, and cancer-related distress in those who undergo testing, and whether these outcomes differ by ethnicity (Hispanic vs non-Hispanic), or sociocultural or demographic factors. Final outcome data collection is anticipated to be complete by October 2017, at which point data analysis will commence. This study has important implications for personalized genomics in the context of melanoma risk, and may be broadly applicable as a model for delivery of personalized genomic feedback for other health conditions. ©Jennifer L Hay, Marianne Berwick, Kate Zielaskowski, Kirsten AM White, Vivian M Rodríguez, Erika Robers, Dolores D Guest, Andrew Sussman, Yvonne Talamantes, Matthew R Schwartz, Jennie Greb, Jessica Bigney, Kimberly A Kaphingst, Keith Hunley, David B Buller. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 25.04.2017.

  11. A new improved protocol for in vitro intratubular dentinal bacterial contamination for antimicrobial endodontic tests: standardization and validation by confocal laser scanning microscopy

    Directory of Open Access Journals (Sweden)

    Flaviana Bombarda de ANDRADE

    2015-01-01

    Full Text Available Objectives To compare three methods of intratubular contamination that simulate endodontic infections using confocal laser scanning microscopy (CLSM. Material and Methods Two pre-existing models of dentinal contamination were used to induce intratubular infection (groups A and B. These methods were modified in an attempt to improve the model (group C. Among the modifications it may be included: specimen contamination for five days, ultrasonic bath with BHI broth after specimen sterilization, use of E. faecalis during the exponential growth phase, greater concentration of inoculum, and two cycles of centrifugation on alternate days with changes of culture media. All specimens were longitudinally sectioned and stained with of LIVE/DEAD® for 20 min. Specimens were assessed using CLSM, which provided images of the depth of viable bacterial proliferation inside the dentinal tubules. Additionally, three examiners used scores to classify the CLSM images according to the following parameters: homogeneity, density, and depth of the bacterial contamination inside the dentinal tubules. Kruskal-Wallis and Dunn’s tests were used to evaluate the live and dead cells rates, and the scores obtained. Results The contamination scores revealed higher contamination levels in group C when compared with groups A and B (p0.05. The volume of live cells in group C was higher than in groups A and B (p<0.05. Conclusion The new protocol for intratubular infection resulted in high and uniform patterns of bacterial contamination and higher cell viability in all specimens when compared with the current methods.

  12. A new improved protocol for in vitro intratubular dentinal bacterial contamination for antimicrobial endodontic tests: standardization and validation by confocal laser scanning microscopy.

    Science.gov (United States)

    Andrade, Flaviana Bombarda de; Arias, Marcela Paola Castro; Maliza, Amanda Garcia Alves; Duarte, Marco Antonio Hungaro; Graeff, Márcia Sirlene Zardin; Amoroso-Silva, Pablo Andrés; Midena, Raquel Zanin; Moraes, Ivaldo Gomes de

    2015-01-01

    To compare three methods of intratubular contamination that simulate endodontic infections using confocal laser scanning microscopy (CLSM). Two pre-existing models of dentinal contamination were used to induce intratubular infection (groups A and B). These methods were modified in an attempt to improve the model (group C). Among the modifications it may be included: specimen contamination for five days, ultrasonic bath with BHI broth after specimen sterilization, use of E. faecalisduring the exponential growth phase, greater concentration of inoculum, and two cycles of centrifugation on alternate days with changes of culture media. All specimens were longitudinally sectioned and stained with of LIVE/DEAD for 20 min. Specimens were assessed using CLSM, which provided images of the depth of viable bacterial proliferation inside the dentinal tubules. Additionally, three examiners used scores to classify the CLSM images according to the following parameters: homogeneity, density, and depth of the bacterial contamination inside the dentinal tubules. Kruskal-Wallis and Dunn's tests were used to evaluate the live and dead cells rates, and the scores obtained. The contamination scores revealed higher contamination levels in group C when compared with groups A and B (p0.05). The volume of live cells in group C was higher than in groups A and B (p<0.05). The new protocol for intratubular infection resulted in high and uniform patterns of bacterial contamination and higher cell viability in all specimens when compared with the current methods.

  13. A ton is not always a ton: A road-test of landfill, manure, and afforestation/reforestation offset protocols in the U.S. carbon market

    International Nuclear Information System (INIS)

    Lee, Carrie M.; Lazarus, Michael; Smith, Gordon R.; Todd, Kimberly; Weitz, Melissa

    2013-01-01

    Highlights: • Protocols are the foundation of an offset program. • Using sample projects, we “road test” landfill, manure and afforestation protocols from 5 programs. • For a given project, we find large variation in the volume of offsets generated. • Harmonization of protocols can increase the likelihood that “a ton is a ton”. • Harmonization can enhance prospects for linking emission trading systems. -- Abstract: The outcome of recent international climate negotiations suggests we are headed toward a more fragmented carbon market, with multiple emission trading and offset programs operating in parallel. To effectively harmonize and link across programs, it will be important to ensure that across offset programs and protocols that a “ton is a ton”. In this article, we consider how sample offsets projects in the U.S. carbon market are treated across protocols from five programs: the Clean Development Mechanism, Climate Action Reserve, Chicago Climate Exchange, Regional Greenhouse Gas Initiative, and the U.S. EPA's former program, Climate Leaders. We find that differences among protocols for landfill methane, manure management, and afforestation/reforestation project types in accounting boundary definitions, baseline setting methods, measurement rules, emission factors, and discounts lead to differences in offsets credited that are often significant (e.g. greater than 50%). We suggest opportunities for modification and harmonization of protocols that can improve offset quality and credibility and enhance prospects for future linking of trading units and systems

  14. Stabilizing Group Treatment for Complex Posttraumatic Stress Disorder Related to Childhood Abuse Based on Psycho-Education and Cognitive Behavioral Therapy: A Pilot Study

    Science.gov (United States)

    Dorrepaal, Ethy; Thomaes, Kathleen; Smit, Johannes H.; van Balkom, Anton J. L. M.; van Dyck, Richard; Veltman, Dick J.; Draijer, Nel

    2010-01-01

    Objective: This study tests a Stabilizing Group Treatment protocol, designed for the management of the long-term sequelae of child abuse, that is, Complex Posttraumatic Stress Disorder (Complex PTSD). Evidence-based treatment for this subgroup of PTSD patients is largely lacking. This stabilizing treatment aims at improving Complex PTSD using…

  15. Stabilizing group treatment for Complex Posttraumatic Stress Disorder related to childhood abuse based on psycho-education and cognitive behavioral therapy: A pilot study

    NARCIS (Netherlands)

    Dorrepaal, E.; Thomaes, K.; Smit, J.H.; van Balkom, A.J.L.M.; van Dyck, R.; Veltman, D.J.; Draijer, P.J.

    2010-01-01

    Objective: This study tests a Stabilizing Group Treatment protocol, designed for the management of the long-term sequelae of child abuse, that is, Complex Posttraumatic Stress Disorder (Complex PTSD). Evidence-based treatment for this subgroup of PTSD patients is largely lacking. This stabilizing

  16. Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±-anatoxin A poisoning

    Directory of Open Access Journals (Sweden)

    Subham Banerjee

    2014-06-01

    Full Text Available The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  17. Testing the implementation and sustainment facilitation (ISF) strategy as an effective adjunct to the Addiction Technology Transfer Center (ATTC) strategy: study protocol for a cluster randomized trial.

    Science.gov (United States)

    Garner, Bryan R; Zehner, Mark; Roosa, Mathew R; Martino, Steve; Gotham, Heather J; Ball, Elizabeth L; Stilen, Patricia; Speck, Kathryn; Vandersloot, Denna; Rieckmann, Traci R; Chaple, Michael; Martin, Erika G; Kaiser, David; Ford, James H

    2017-11-17

    Improving the extent to which evidence-based practices (EBPs)-treatments that have been empirically shown to be efficacious or effective-are integrated within routine practice is a well-documented challenge across numerous areas of health. In 2014, the National Institute on Drug Abuse funded a type 2 effectiveness-implementation hybrid trial titled the substance abuse treatment to HIV Care (SAT2HIV) Project. Aim 1 of the SAT2HIV Project tests the effectiveness of a motivational interviewing-based brief intervention (MIBI) for substance use as an adjunct to usual care within AIDS service organizations (ASOs) as part of its MIBI Experiment. Aim 2 of the SAT2HIV Project tests the effectiveness of implementation and sustainment facilitation (ISF) as an adjunct to the Addiction Technology Transfer Center (ATTC) model for training staff in motivational interviewing as part of its ISF Experiment. The current paper describes the study protocol for the ISF Experiment. Using a cluster randomized design, case management and leadership staff from 39 ASOs across the United States were randomized to receive either the ATTC strategy (control condition) or the ATTC + ISF strategy (experimental condition). The ATTC strategy is staff-focused and includes 10 discrete strategies (e.g., provide centralized technical assistance, conduct educational meetings, provide ongoing consultation). The ISF strategy is organization-focused and includes seven discrete strategies (e.g., use an implementation advisor, organize implementation team meetings, conduct cyclical small tests of change). Building upon the exploration-preparation-implementation-sustainment (EPIS) framework, the effectiveness of the ISF strategy is examined via three staff-level measures: (1) time-to-proficiency (i.e., preparation phase outcome), (2) implementation effectiveness (i.e., implementation phase outcome), and (3) level of sustainment (i.e., sustainment phase outcome). Although not without limitations, the ISF

  18. Testing the implementation and sustainment facilitation (ISF strategy as an effective adjunct to the Addiction Technology Transfer Center (ATTC strategy: study protocol for a cluster randomized trial

    Directory of Open Access Journals (Sweden)

    Bryan R. Garner

    2017-11-01

    Full Text Available Abstract Background Improving the extent to which evidence-based practices (EBPs—treatments that have been empirically shown to be efficacious or effective—are integrated within routine practice is a well-documented challenge across numerous areas of health. In 2014, the National Institute on Drug Abuse funded a type 2 effectiveness–implementation hybrid trial titled the substance abuse treatment to HIV Care (SAT2HIV Project. Aim 1 of the SAT2HIV Project tests the effectiveness of a motivational interviewing-based brief intervention (MIBI for substance use as an adjunct to usual care within AIDS service organizations (ASOs as part of its MIBI Experiment. Aim 2 of the SAT2HIV Project tests the effectiveness of implementation and sustainment facilitation (ISF as an adjunct to the Addiction Technology Transfer Center (ATTC model for training staff in motivational interviewing as part of its ISF Experiment. The current paper describes the study protocol for the ISF Experiment. Methods Using a cluster randomized design, case management and leadership staff from 39 ASOs across the United States were randomized to receive either the ATTC strategy (control condition or the ATTC + ISF strategy (experimental condition. The ATTC strategy is staff-focused and includes 10 discrete strategies (e.g., provide centralized technical assistance, conduct educational meetings, provide ongoing consultation. The ISF strategy is organization-focused and includes seven discrete strategies (e.g., use an implementation advisor, organize implementation team meetings, conduct cyclical small tests of change. Building upon the exploration–preparation–implementation–sustainment (EPIS framework, the effectiveness of the ISF strategy is examined via three staff-level measures: (1 time-to-proficiency (i.e., preparation phase outcome, (2 implementation effectiveness (i.e., implementation phase outcome, and (3 level of sustainment (i.e., sustainment phase outcome

  19. Observational study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers - protocol study

    Directory of Open Access Journals (Sweden)

    Hirata Raquel P

    2011-12-01

    enrollment of this study protocol, the expectation is to encounter predictive NEP values for different degrees of OSA in order to contribute toward an early diagnosis of this condition and reduce its impact and complications among commercial interstate bus drivers. Trial registration Registro Brasileiro de Ensaios Clinicos (local acronym RBEC [Internet]: Rio de Janeiro (RJ: Instituto de Informaçao Cientifica e Tecnologica em Saude (Brazil; 2010 - Identifier RBR-7dq5xx. Cross-sectional study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers; 2011 May 31 [7 pages]. Available from http://www.ensaiosclinicos.gov.br/rg/RBR-7dq5xx/.

  20. Beyond protocols

    DEFF Research Database (Denmark)

    Vanderhoeven, Sonia; Branquart, Etienne; Casaer, Jim

    2017-01-01

    Risk assessment tools for listing invasive alien species need to incorporate all available evidence and expertise. Beyond the wealth of protocols developed to date, we argue that the current way of performing risk analysis has several shortcomings. In particular, lack of data on ecological impacts...... process can be applied to better capture opinions of different experts, thereby maximizing the evidential basis. Elaborating on manageability of invasive species is further needed to fully answer all risk analysis requirements. Tackling the issue of invasive species urges better handling of the acquired...

  1. Identification, synthesis and characterization of process related impurities of benidipine hydrochloride, stress-testing/stability studies and HPLC/UPLC method validations

    Directory of Open Access Journals (Sweden)

    Esen Bellur Atici

    2015-08-01

    Full Text Available Benidipine hydrochloride, used as an antihypertensive agent and long-acting calcium antagonist, is synthesized for commercial use as a drug substance in highly pure form. During the synthetic process development studies of benidipine, process related impurities were detected. These impurities were identified, synthesized and characterized and mechanisms of their formation were discussed in detail. After all standardization procedures, they were used as reference standards for analytical studies. In addition, a separate HPLC method was developed and validated for detection of residual 1-benzylpiperidin-3-ol (Ben-2, which is used during benidipine synthesis and controlled as a potential process related impurity. As complementary of this work, stress-testing studies of benidipine were carried out under specified conditions and a stability-indicating UPLC assay method was developed, validated and used during stability studies of benidipine. Keywords: Benidipine, Impurities, Synthesis, Characterization, Validation, Stability

  2. Study on seismic stability of seawall in man-made island. Pt. 1. Shaking table tests on dynamic behavior of seawall constructed on the bedrock

    International Nuclear Information System (INIS)

    Tochigi, Hitoshi; Kanatani, Mamoru; Kawai, Tadashi

    1999-01-01

    In the development of siting technology for off-shore nuclear power plants on man-made island, assessing the stability of seawall which ensures the safety of backfill ground against ocean waves and earthquakes is indispensable. In assessing seismic stability of seawall, evaluation of dynamic nonlinear behavior like sliding and settlement is an important factor. For this purpose, shake-table tests of seawall model have been carried out. By the experiments in the case of well compacted backfill ground, it is indicated that dynamic failure of caisson type seawall constructed on the strong seabed ground is mainly induced by the sliding of caisson toward the sea and followed by the settlement of backfill ground. And as the influence of armour embankment on the seismic stability of seawall, we experimentally showed that the sliding displacement of caisson during earthquake is reduced by the lateral pressure of armour units and armour embankment works effectively to rise up earthquake resistance capability of seawall. (author)

  3. Using the Sonoran Desert test site to monitor the long-term radiometric stability of the Landsat TM/ETM+ and Terra MODIS sensors

    Science.gov (United States)

    Angal, A.; Xiong, X.; Choi, T.; Chander, G.; Wu, A.

    2009-01-01

    Pseudo-invariant ground targets have been extensively used to monitor the long-term radiometric calibration stability of remote sensing instruments. The NASA MODIS Characterization Support Team (MCST), in collaboration with members from the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center, has previously demonstrated the use of pseudo-invariant ground sites for the long-term stability monitoring of Terra MODIS and Landsat 7 ETM+ sensors. This paper focuses on the results derived from observations made over the Sonoran Desert. Additionally, Landsat 5 TM data over the Sonoran Desert site were used to evaluate the temporal stability of this site. Top-ofatmosphere (TOA) reflectances were computed for the closely matched TM, ETM+, and MODIS spectral bands over selected regions of interest. The impacts due to different viewing geometries, or the effect of test site Bi-directional Reflectance Distribution Function (BRDF), are also presented. ?? 2009 SPIE.

  4. Moisture related test protocols for HVS testing

    CSIR Research Space (South Africa)

    Denneman, E

    2008-10-01

    Full Text Available In order to provide guidance on the possible methodologies for evaluating specifically moisture related pavement response using the Heavy Vehicle Simulator (HVS), this paper describes the objectives, potential effects and available methods...

  5. Validation of a Five Plate Test, the STAR protocol, for the screening of antibiotic residues in muscle from different animal species according to European Decision 2002/657/EC.

    Science.gov (United States)

    Gaudin, V; Hedou, C; Rault, A; Verdon, E

    2010-07-01

    The STAR protocol is a Five Plate Test (FPT) developed several years ago at the Community Reference Laboratory (CRL) for the screening of antimicrobial residues in milk and muscle. This paper presents the validation of this method according to European Decision 2002/657/EC and to an internal guideline for validation. A validation protocol based on 'simulated tissues' and on a list of 16 representative antimicrobials to be validated was implemented in our laboratory during several months for the STAR protocol. The performance characteristics of the method were determined (specificity, detection capabilities CCbeta, applicability, ruggedness). In conclusion, the STAR protocol is applicable to the broad-spectrum detection of antibiotic residues in muscles of different animal species (pig, cattle, sheep, poultry). The method has good specificity (false-positive rate = 4%). The detection capabilities were determined for 16 antibiotics from different families in relation to their respective maximum residue limit (MRL): beta-lactams (penicillins and cephalosporins sensitivity of the STAR protocol towards aminoglycosides (> 8 MRL) and florfenicol (MRL). The two objectives of this study were met: firstly, to validate the STAR protocol according to European Decision 2002/657/EC, then to demonstrate that the validation guideline developed to implement this decision is applicable to microbiological plate tests even for muscle. The use of simulated tissue appeared a good compromise between spiked discs with antibiotic solutions and incurred tissues. In addition, the choice of a list of representative antibiotics allowed the reduction of the scope of the validation, which was already costly in time and effort.

  6. Survey of needs and capabilities for wind tunnel testing of dynamic stability of aircraft at high angles of attack

    Science.gov (United States)

    Orlik-Ruckemann, K. J.

    1973-01-01

    A survey was conducted relative to future requirements for dynamic stability information for such aerospace vehicles as the space shuttle and advanced high performance military aircraft. High-angle-of-attack and high-Reynolds number conditions were emphasized. A review was made of the wind-tunnel capabilities in North America for measuring dynamic stability derivatives, revealing an almost total lack of capabilities that could satisfy these requirements. Recommendations are made regarding equipment that should be constructed to remedy this situation. A description is given of some of the more advanced existing capabilities, which can be used to at least partly satisfy immediate demands.

  7. Moderate financial incentive does not appear to influence the P300 Concealed Information Test (CIT) effect in the Complex Trial Protocol (CTP) version of the CIT in a forensic scenario, while affecting P300 peak latencies and behavior.

    Science.gov (United States)

    Rosenfeld, J Peter; Sitar, Evan; Wasserman, Joshua; Ward, Anne

    2018-03-01

    Previous research indicated that the skin conductance response (SCR) of the Autonomic Nervous System (ANS) in the Concealed Information Test (CIT) is typically increased in subjects who are financially and otherwise incentivized to defeat the CIT (the paradoxical "motivational impairment" effect). This is not the case for RT-based CITs, nor for P300 tests based on the 3-stimulus protocol or Complex Trial Protocol for detection of cognitive malingering (although these are not the same as forensic CITs). The present report extends earlier studies of malingerers by running five groups of subjects (15-16 per group yielding 78 total) in a mock crime (forensic) scenario: paid (to beat the test) and unpaid, instructed and uninstructed, and simply guilty. There was no evidence that the "CIT effect" (probe-minus-irrelevant P300 differences) differed among groups, although behavioral differences among groups were seen. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Approaches to Formal Verification of Security Protocols

    OpenAIRE

    Lal, Suvansh; Jain, Mohit; Chaplot, Vikrant

    2011-01-01

    In recent times, many protocols have been proposed to provide security for various information and communication systems. Such protocols must be tested for their functional correctness before they are used in practice. Application of formal methods for verification of security protocols would enhance their reliability thereby, increasing the usability of systems that employ them. Thus, formal verification of security protocols has become a key issue in computer and communications security. In...

  9. Improving early childhood care and development, HIV-testing, treatment and support, and nutrition in Mokhotlong, Lesotho: study protocol for a cluster randomized controlled trial.

    Science.gov (United States)

    Tomlinson, Mark; Skeen, Sarah; Marlow, Marguerite; Cluver, Lucie; Cooper, Peter; Murray, Lynne; Mofokeng, Shoeshoe; Morley, Nathene; Makhetha, Moroesi; Gordon, Sarah; Esterhuizen, Tonya; Sherr, Lorraine

    2016-11-09

    Since 1990, the lives of 48 million children under the age of 5 years have been saved because of increased investments in reducing child mortality. However, despite these unprecedented gains, 250 million children younger than 5 years in low- and middle-income countries (LMIC) cannot meet their developmental potential due to poverty, poor health and nutrition, and lack of necessary stimulation and care. Lesotho has high levels of poverty, HIV, and malnutrition, all of which affect child development outcomes. There is a unique opportunity to address these complex issues through the widespread network of informal preschools in rural villages in the country, which provide a setting for inclusive, integrated Early Childhood Care and Development (ECCD) and HIV and nutrition interventions. We are conducting a cluster randomised controlled trial in Mokhotlong district, Lesotho, to evaluate a newly developed community-based intervention program to integrate HIV-testing and treatment services, ECCD, and nutrition education for caregivers with children aged 1-5 years living in rural villages. Caregivers and their children are randomly assigned by village to intervention or control condition. We select, train, and supervise community health workers recruited to implement the intervention, which consists of nine group-based sessions with caregivers and children over 12 weeks (eight weekly sessions, and a ninth top-up session 1 month later), followed by a locally hosted community health outreach day event. Group-based sessions focus on using early dialogic book-sharing to promote cognitive development and caregiver-child interaction, health-related messages, including motivation for HIV-testing and treatment uptake for young children, and locally appropriate nutrition education. All children aged 1-5 years and their primary caregivers living in study villages are eligible for participation. Caregivers and their children will be interviewed and assessed at baseline, after

  10. Adult and adolescent livestock productive asset transfer programmes to improve mental health, economic stability and family and community relationships in rural South Kivu Province, Democratic Republic of Congo: a protocol of a randomised controlled trial.

    Science.gov (United States)

    Kohli, Anjalee; Perrin, Nancy A; Remy, Mitima Mpanano; Alfred, Mirindi Bacikenge; Arsene, Kajabika Binkurhorhwa; Nadine, Mwinja Bufole; Heri, Banyewesize Jean; Clovis, Mitima Murhula; Glass, Nancy

    2017-03-14

    People living in poverty have limited access to traditional financial institutions. Microfinance programmes are designed to meet this gap and show promise in improving income, economic productivity and health. Our Congolese-US community academic research partnership developed two livestock productive asset transfer programmes, Pigs for Peace (PFP) and Rabbits for Resilience (RFR), to address the interlinked health, social and economic well-being of individuals, their families and communities. The community-based randomised controlled trials examine the effectiveness of PFP and RFR to improve health, economic stability, and family and community relationships among male and female adults and adolescents living in 10 rural, postconflict villages of eastern Democratic Republic of Congo. PFP participants include adult permanent residents of rural villages; adolescent participants in RFR include male and female adolescents 10-15 years old living in the selected rural villages. Participants were randomised to intervention or delayed control group. Participants in PFP completed baseline interview prior to intervention and follow-up interview at 6, 12 and 18 months postintervention. In RFR, participants completed baseline interview prior to intervention and follow-up interview at 6, 12 and 18 months postbaseline. The primary outcome of both trials, the change in baseline mental health distress at 18 months in the intervention group (adults, adolescents) compared to control group, is used to calculate sample size. The Johns Hopkins Medical Institute Internal Review Board approved this protocol. A committee of respected Congolese educators and community members (due to lack of local ethics review board) approved the study. The findings will provide important information on the potential for community-led sustainable development initiatives to build on traditional livelihood (livestock raising, agriculture) to have a sustained health, economic and social impact on the

  11. Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

    OpenAIRE

    Cheng, Kwok Kin; Yeung, Chin Fung; Ho, Shuk Wai; Chow, Shing Fung; Chow, Albert H. L.; Baum, Larry

    2012-01-01

    The therapeutic effects of curcumin in treating Alzheimer’s disease (AD) depend on the ability to penetrate the blood–brain barrier. The latest nanoparticle technology can help to improve the bioavailability of curcumin, which is affected by the final particle size and stability. We developed a stable curcumin nanoparticle formulation to test in vitro and in AD model Tg2576 mice. Flash nanoprecipitation of curcumin, polyethylene glycol-polylactic acid co-block polymer, and polyvinylpyrrolidon...

  12. Development of a Test for Evaluation of the Hydrothermal Stability of Sorbents Used in Closed-Loop CO2 Removal Systems

    Science.gov (United States)

    Knox, James C.; Gauto, Hernando; Miller, Lee A.

    2015-01-01

    The International Space Station Carbon Dioxide Removal Assembly uses zeolite 5A molecular sieve material packed into beds for the capture of cabin CO2. The beds are cyclically heated to drive off the CO2 and restore the removal capacity. Over time, the sorbent material has been found to break down resulting in dust that restricts flow through the beds. Humidity adsorbed in the 5A zeolite when it is heated is a suspected cause of this sorbent degradation. To evaluate the impact of adsorbed water during thermal cycling, the Hydrothermal Stability Test was developed. The test configuration provides comparative side-by-side flow restriction data for two sorbent materials at specifically controlled humidity levels. While the initial focus of the testing is on 5A zeolite materials currently used on the ISS, the system will also be used to evaluate future candidate materials. This paper describes the approach, the test system, current results, and future testing.

  13. Evolution of oxidation in soybean oil and its biodiesel under the conditions of the oxidation stability test

    Directory of Open Access Journals (Sweden)

    Pereira, G. G.

    2013-12-01

    Full Text Available The objective of this study was to know the evolution of the oxidation of soybean oil and biodiesel under the conditions of the oxidation stability test (110 °C using the Rancimat apparatus. Samples were analyzed at different periods of time until the end of the induction period. The analytical determinations related to the changes in oxidation include peroxide value, anisidine value, natural tocopherols and polar compounds. Acid value, kinematic viscosity, polymers and ester content were also analyzed because of their relevance in the evaluation of biodiesel quality. Results showed that only peroxide value and the group of polar compounds including hydroperoxides, i.e. oxidized monomeric TAG in the oil and oxidized monomeric FAME in the biodiesel increased significantly during the early oxidation stage. The end of the induction period was marked by a rapid increase in polymerization compounds and the exhaustion of tocopherols. Significant changes in acid value, viscosity and ester content were only observed after the end of the induction period.El objetivo de este estudio fue conocer la evolución de la oxidación del aceite de soja y de su biodiesel a 110 °C en las condiciones del método estándar para la determinación de la estabilidad oxidativa, usando el aparato Rancimat. Las muestras se analizaron en diferentes períodos de tiempo hasta que el período de inducción fue sobrepasado. Se determinaron los índices de peróxidos y anisidina, los tocoferoles y los compuestos polares cuyos cambios están relacionados con el desarrollo de la alteración oxidativa. Además, fueron determinados el índice de acidez, la viscosidad y el contenido en ésteres, de interés en el análisis de la calidad del biodiesel. Los resultados indicaron que sólo el índice de peróxidos y el grupo de compuestos polares que incluye los hidroperóxidos (triglicéridos oxidados monómeros en el aceite y ésteres metílicos oxidados monómeros en el biodiesel

  14. Viability testing and transplantation of marginal livers (VITTAL) using normothermic machine perfusion: study protocol for an open-label, non-randomised, prospective, single-arm trial.

    Science.gov (United States)

    Laing, Richard W; Mergental, Hynek; Yap, Christina; Kirkham, Amanda; Whilku, Manpreet; Barton, Darren; Curbishley, Stuart; Boteon, Yuri L; Neil, Desley A; Hübscher, Stefan G; Perera, M Thamara P R; Muiesan, Paolo; Isaac, John; Roberts, Keith J; Cilliers, Hentie; Afford, Simon C; Mirza, Darius F

    2017-11-28

    The use of marginal or extended criteria donor livers is increasing. These organs carry a greater risk of initial dysfunction and early failure, as well as inferior long-term outcomes. As such, many are rejected due to a perceived risk of use and use varies widely between centres. Ex situ normothermic machine perfusion of the liver (NMP-L) may enable the safe transplantation of organs that meet defined objective criteria denoting their high-risk status and are currently being declined for use by all the UK transplant centres. Viability testing and transplantation of marginal livers is an open-label, non-randomised, prospective, single-arm trial designed to determine whether currently unused donor livers can be salvaged and safely transplanted with equivalent outcomes in terms of patient survival. The procured rejected livers must meet predefined criteria that objectively denote their marginal condition. The liver is subjected to NMP-L following a period of static cold storage. Organs metabolising lactate to ≤2.5 mmol/L within 4 hours of the perfusion commencing in combination with two or more of the following parameters-bile production, metabolism of glucose, a hepatic arterial flow rate ≥150 mL/min and a portal venous flow rate ≥500 mL/min, a pH ≥7.30 and/or maintain a homogeneous perfusion-will be considered viable and transplanted into a suitable consented recipient. The coprimary outcome measures are the success rate of NMP-L to produce a transplantable organ and 90-day patient post-transplant survival. The protocol was approved by the National Research Ethics Service (London-Dulwich Research Ethics Committee, 16/LO/1056), the Medicines and Healthcare Products Regulatory Agency and is endorsed by the National Health Service Blood and Transplant Research, Innovation and Novel Technologies Advisory Group. The findings of this trial will be disseminated through national and international presentations and peer-reviewed publications. NCT02740608

  15. Luminescence dating of the Stratzing loess profile (Austria) – Testing the potential of an elevated temperature post-IR IRSL protocol

    DEFF Research Database (Denmark)

    Thiel, Christine; Buylaert, Jan-Pieter; Murray, Andrew

    2011-01-01

    less fading and is thus less dependent on accurate fading corrections. This study builds upon these investigations and applies a post-IR IRSL SAR dating protocol to polymineral fine-grain samples of the loess/palaeosol sequence in Stratzing, Lower Austria. After a preheat at 320 °C (60 s) and an IR...

  16. Stability Landscape of Shell Buckling

    Science.gov (United States)

    Virot, Emmanuel; Kreilos, Tobias; Schneider, Tobias M.; Rubinstein, Shmuel M.

    2017-12-01

    We measure the response of cylindrical shells to poking and identify a stability landscape, which fully characterizes the stability of perfect shells and imperfect ones in the case where a single defect dominates. We show that the landscape of stability is independent of the loading protocol and the poker geometry. Our results suggest that the complex stability of shells reduces to a low dimensional description. Tracking ridges and valleys of this landscape defines a natural phase-space coordinates for describing the stability of shells.

  17. Intraprostatic fiducials for localization of the prostate gland: Monitoring intermarker distances during radiation therapy to test for marker stability

    International Nuclear Information System (INIS)

    Kupelian, Patrick A.; Willoughby, Twyla R.; Meeks, Sanford L.; Forbes, Alan; Wagner, Thomas; Maach, Mourad; Langen, Katja M.

    2005-01-01

    Purpose: The use of intraprostatic fiducials as surrogates for prostate gland position assumes that the markers are rigidly positioned within the prostate. To test this assumption, the intermarker distances (IMD) of implanted markers was monitored during the full course of radiation therapy to determine marker stability within the prostate gland. Methods and Materials The analysis is performed on 56 patients treated with intensity-modulated radiotherapy. A total of 168 markers (3 markers per patient) were implanted. Two high-resolution X-rays were acquired before treatment delivery to visualize the position of the implanted markers. A total of 2,037 daily alignments were performed on the 56 cases (average: 36 alignments per patient). Each pair of X-ray images allows the computation of the 3 IMDs. A total of 6,111 IMDs were available for analysis. To study variations in marker position, daily IMDs were compared with the IMD that was observed during the first alignment. We defined the variation in the IMD as the important measure of intrinsic marker position variation. The standard deviation (SD) of IMD variations was studied as a measure of the extent of marker position variation. Particular attention was given to cases in which significant intermarker variations were observed. Results The average directional variation of all IMDs (± SD) was -0.31 (±1.41) mm. The average absolute variation of all IMDs (± SD) was 1.01 (±1.03) mm. The largest observed variation in IMD was 10.2 mm. Among the individual 56 patients, the SDs of the IMD variations were computed and found to range from 0.4 to 4.2 mm. In 54 of the 56 patients (96%), the variations of all 3 IMDs had SD of 4.0 mm or less, which indicates little variation in the relative position of the markers. Only in 2 patients did any of the IMDs vary, with SD that exceeded 4.0 mm, which indicated noticeable and consistent marker-position variation. The maximum observed SD in the IMD variation was 4.2 mm. In each of